<?xml version="1.0" encoding="UTF-8"?>
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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0N4</accession>
    <name>A0A4Q9L0N4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DUF788 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0866p0030</name>
        <name evidence="3" type="ORF">CWI38_0313p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000866">
        <property type="protein sequence ID" value="TBU00898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000313">
        <property type="protein sequence ID" value="TBU15320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0N4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0866p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0313p0030"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="129" mass="15637" checksum="B62A045CF2FA7D4F" modified="2019-07-31" version="1">MAGTSSKKILKRNNEIIKNLKNLETFVLIVSCILYRPLSINKIMIFIFKSFPELFGIFFIYKSGYRKEKDKEYYVSLDSKGIISMLFDFVYISQITKILTYFYNSFYFLYFILIISIVYEFYFRFKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1S8</accession>
    <name>A0A4Q9L1S8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0904p0030</name>
        <name evidence="10" type="ORF">CWI38_0387p0040</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000904">
        <property type="protein sequence ID" value="TBU00781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000387">
        <property type="protein sequence ID" value="TBU13583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1S8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1S8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0904p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0387p0040"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU00781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="124" mass="15083" checksum="FA0243C0E5A35DCF" modified="2019-07-31" version="1">MIHQFFIVNRFGSMLYSYEEGIKSEDNKLLVLTSTLHSLYYIMNQIKENDRREIRMYLKKRIITIFCLVSGAMFIFVSNNDIKREVFNKIYRMYIDYVMCNPFYIMDMPINCHLFVPEEILKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1U0</accession>
    <name>A0A4Q9L1U0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0729p0020</name>
        <name evidence="8" type="ORF">CWI38_0849p0030</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000729">
        <property type="protein sequence ID" value="TBU01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000849">
        <property type="protein sequence ID" value="TBU12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1U0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1U0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0729p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0849p0030"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="6">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="242"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="515"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="785" mass="87705" checksum="6909453F599B6249" modified="2019-07-31" version="1">MSTSPQKQSNRPDLSTAILESKTKNTLIVKDPSSPLLPYHTILNPATLSSLNLFKNDYVLVKGRKRREAVFVLFEDPKVPPNTIILSKESRNNLRIHIGDTVKLYAVETLHKITHLEMFPIDDAIEGITGNIFEAFLESFLVNNIPLSLGNIYLIRSGGKVVEFKIVKMVLENNKEGLHGHTYPETQVYSDSTVPRSEIEQEFQLIGYDDVGGCRKQMAQIRELVELPLRHPGLYKRIGVKPPKGILLYGPPGTGKTLIARAIANETGAFLFIINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFMDEIDAIAPKREKTHGEVERRIVSQLLTLMDGMKARSNVIVLGATNRPNSIDSALRRYGRFDREIEIGIPDAIGRLEILRIHTRNMKLASNVDLERVANETHGFVGSDIASLCSEAALQQIREKLPLIDLDTQKIDAAILASLQVTKENFEYSIRNTDPSSLRETVVQVPNVKWGDIGGLENVKRELRETVQYPVEHADKFLKFGMNPSKGVLFYGPPGCGKTLLAKAIASECQANFISIKGPELLTMWVGESEANVRDIFDKARAAAPCVIFFDELDSIAKSRSTNAGDSGVTDRVLNMLLSEMDGVNQKKNVFIIGATNRPDQIDSALMRPGRLDQLIYIPLPDLKSRESILKATLNKTPLNSDVNLSDIATRTEKFSGADLTEICQRSCKLAIRECIEYEIKESKKRKELGENAIDVEFEDPVPNLCMRHFEEAMKFARKSVNDAELERYEAFARSMKVDMKKGGENDEENGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2N8</accession>
    <name>A0A4Q9L2N8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0654p0030</name>
        <name evidence="11" type="ORF">CWI38_0184p0040</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="PITJ01000654">
        <property type="protein sequence ID" value="TBU01678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2N8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L2N8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0654p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0040"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="197"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU01678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="368" mass="43625" checksum="97F53B0D9E4FAD5D" modified="2019-07-31" version="1">MSNSHNFWSTQPIKVGEGNGTIQVPEEIRKEPIKLPDPFVFKTFNFEKDINALYLLLKENYVEDLASDFRLEYSRDFLAWQLNDPKAKPEYAVCLLHQTKLVGFALGKELILCVSDKVENFLSVNFLCIDRNLRNQRLAPVIIQELTRRANLNGIFHAIFTSGKKLPFDFASSRYYHRPINTKKLIDVEFCVKPEDENEMIEYFQINYKIRPGIRQMQNGDLPKVFELYKQECKKYDLYQVYDFKDFEYNFKNRENIFYTYVNEEEGEIKEFFSFFVINSLLVKDLRIKVKTAYIFYYSTDNTTTIMQEMISEAKNQGCDLVNSLLIMKNELFLEDLNFLPGNGVLNYYFFNWKTKSIENEKIFFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3P2</accession>
    <name>A0A4Q9L3P2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0555p0020</name>
        <name evidence="4" type="ORF">CWI38_0096p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000555">
        <property type="protein sequence ID" value="TBU02107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000096">
        <property type="protein sequence ID" value="TBU20285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3P2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3P2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0555p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0096p0010"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="218"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="273" mass="31436" checksum="F8892124B7873C66" modified="2019-07-31" version="1">MTITLTIKHQSRSKELSLEINTSLKDLKTEIESIFCIPVSLQLVFYKDRLLTDESKSLKELDIINESEITVRKKNITVQNVQPKQKESFEKIILSNPMVKNMLKRPEALKSMLDMYPSLKKEMEKNSELRNIMNNPQTFEEFEKMTDNPEYMSQQLKNIDIAMSRLSNIPGGLNMMNSMLKEVRDPVSMAMGPQNTKDFSTGESIEMQVTDAIYNPEQSSENNPIFKYRKELDELKQIGFSDMAKNLEALQLYDGDIESVITFLATEPEKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L5B9</accession>
    <name>A0A4Q9L5B9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0434p0010</name>
        <name evidence="2" type="ORF">CWI38_1177p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000434">
        <property type="protein sequence ID" value="TBU02674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001177">
        <property type="protein sequence ID" value="TBU11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L5B9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0434p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1177p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="57" mass="6481" checksum="CA66F1F46805A416" modified="2019-07-31" version="1">MDWSSKLVEHMANNPPFKPPCYEFEKVNKPTGKRPEGGITEGDYGSLMAVGPMMMYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7S4</accession>
    <name>A0A4Q9L7S4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol-4-phosphate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0266p0050</name>
        <name evidence="4" type="ORF">CWI38_0009p0110</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000266">
        <property type="protein sequence ID" value="TBU03614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7S4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7S4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0266p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0110"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="358" mass="42398" checksum="10BFF660565DF669" modified="2019-07-31" version="1">MEEGLRHNHKLIYNILLGITKAKMRSLENVLESELEEKDIKYSDFILKSYSPKIFNSIRQITGSEYENIESEISTDYILSSEFDKKKDKMIFYSQNFKFVIKIISKIEKNILMCILPEYCVFLSENTSSLITRYFGCYRIKVGGFSPVYFVIMNNILPPNRRPVDIYDLKGSEHGRKGNKTDMFSVLKDIDWCKNKTKLFLSHKRMNFISQLKRDTEFLRDHKIMDYSLFIAIATNGTLDCSIEQNELNSNICVKSKDEDEFEILPFRFPITNEFNSSNSIFSKEYGGYSSDNNSTAFKEIYYIGIIDILTPWSWKKMIENFFYKFFCMKNFSCVEPKVYRKRMLKFVKEHLFYNKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAT9</accession>
    <name>A0A4Q9LAT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0207p0020</name>
        <name evidence="9" type="ORF">CWI38_0178p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="PITJ01000207">
        <property type="protein sequence ID" value="TBU03940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000178">
        <property type="protein sequence ID" value="TBU19896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAT9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LAT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0207p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0178p0020"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000105">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="151" mass="17359" checksum="58C4D2DB2F694A46" modified="2019-07-31" version="1">MEKDSKIQIRDLLASDYKNGFINVLSHLTETGNITEDMFVSQYDLLKYKKDYKIVVAIDTTTQKIVGTGTLFIEHKFIRSLATKGHIEDIVVLPDYRGQHIGQRIIQTLLDCSISLKCYKTALCARDDAVEFYKKCGFEPSEREMVIYHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBT2</accession>
    <name>A0A4Q9LBT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small Rho-like GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0152p0020</name>
        <name evidence="12" type="ORF">CWI38_1281p0020</name>
        <name evidence="11" type="ORF">CWI38_1474p0010</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000152">
        <property type="protein sequence ID" value="TBU04320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001474">
        <property type="protein sequence ID" value="TBU10923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001281">
        <property type="protein sequence ID" value="TBU11290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0152p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1281p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1474p0010"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU04320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="205" mass="23268" checksum="DB2F1B7FC3F7D661" modified="2019-07-31" version="1">MEAKPQDDKSTNKSGKVVVVGDGACGKTCLLEVFKRNRFPEEYIPTVVDNFVKDVVLDDEENTTVTLTLWDTAGQEDYDSVRPLSYKDTDLVLLCYSIENRSMLPNISNKWLYEIKNYCPTASYFLIGLKKDIRTTPTPDINPDKIITYEEGQNISNEINSANFLECSAKTGENVDAVFKAAAEHIRINKSTAKKEKKWYFCFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCJ9</accession>
    <name>A0A4Q9LCJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0007p0020</name>
        <name evidence="4" type="ORF">CWI37_0014p0020</name>
        <name evidence="8" type="ORF">CWI38_0033p0030</name>
        <name evidence="7" type="ORF">CWI38_0242p0010</name>
        <name evidence="6" type="ORF">CWI38_1128p0010</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000014">
        <property type="protein sequence ID" value="TBU05419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000007">
        <property type="protein sequence ID" value="TBU05494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001128">
        <property type="protein sequence ID" value="TBU11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000242">
        <property type="protein sequence ID" value="TBU18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000033">
        <property type="protein sequence ID" value="TBU20695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCJ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0007p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0014p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0033p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0242p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1128p0010"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU05494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="238" mass="27404" checksum="C1A8072A2245246B" modified="2019-07-31" version="1">MEQNIVDKFPSLEKARVCMAHNEYDMASEVYSEVLSAAENIYDQNDPNLCKIYLEYAASLIRGSEEHFVNELEKMVSKRTVGSSRDDDLNIAWDVLEISKSVFIANKDHNDLAQTFYLLGDILLLNNDFTGAITEYVSSIVEIKKCAGKNTLSESEVFYKMATCYEFMEEYEKCVEFLIKMKGISREVDEELNCKIKEVLYKKGEKEKKEKIARGEVTEEESESGEVIDINMNKRQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG28</accession>
    <name>A0A4Q9LG28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2689p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002689">
        <property type="protein sequence ID" value="TBU05870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2689p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="55798" checksum="7F818BC8A987F1B5" modified="2019-07-31" version="1" fragment="single">DYLVHFYRFFMLLVNINASLDQKNGKRVLPKEITILEVENPRRIASFISKNPEICLEKSESCKRTKTGIKTSEREDGDPLKKIPRENQMNDVHHSVKSVISEDIQSQIIPKEKSQKNPAITSNLPISENYSKVDSKSRFQKIIAKHNPRMGLKLNDSFETQQTADKGLIKPYIPYKNDNNTISSSNLYYHDNITKKVNIPKAFRRNRLIPTERIIHSSRKKQSVVETKKKPAEQKEQEKEQKTILNKIKPNIRNVQNEPKFLELFKCNVELKDHDKSITTIKDELSDILYPKKSEKVVNLECIEKCFNVKNYLFYDAKNKTFDFTLETLKENYDFNKILEVGKNLVAIEVLSYLKFDAFGIAETIKLIKYSEIISEVKKSQLNIICVELNYIYEKCGNFTETSIKKGHVIYMHYIWVVIKYSTYLLFDEKLYSNKLHYITTLNKITFFIRKLLSELLIGFNFDPQKVETYRILNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGV5</accession>
    <name>A0A4Q9LGV5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2425p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002425">
        <property type="protein sequence ID" value="TBU07264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2425p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="26694" checksum="FAE9F5A0EA6BB34C" modified="2019-07-31" version="1" fragment="single">MKPNIDFRELNLINRDYSKYIFEILGRLFFEMFVEKYDLSRIKKIYLCNISIDKLDFEALGNLLYLEELEMYRTKFKNIYFSELFCTSREYKIKRLKFTKINIKESDFNFISNLKKLKTLQFYECKIQTPTHSGTNMKLKKEFELEIRYKKYDLSAEIIQLIRSFWTETCQYGTSMGVIISAEMHEEPIPPLNEAKKEEDGVKILKLKNNTPLISQRGTTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH68</accession>
    <name>A0A4Q9LH68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2396p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002396">
        <property type="protein sequence ID" value="TBU07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH68"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LH68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2396p0010"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22033" checksum="EC5930ED67822D3B" modified="2019-07-31" version="1" fragment="single">NKKEKGGITVIYNYNQSKDEDAVEVEIVKGILTEYRINNAEVVFNEKCSVDEFIDCVDGNRKYVPCLYVLNKIDCIGIKELDLIYRIPNCVPVCAHLGWNFDDLLSKSWDYLKLIRVYAKPRGMAIDYEDPVILREERKKIEDFCNSIHKSIMSKFKYALVWGTSVKHNPQRVGKDHVLNDSDVVQIVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJJ8</accession>
    <name>A0A4Q9LJJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tat binding protein 1-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2293p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002293">
        <property type="protein sequence ID" value="TBU08197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJJ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2293p0010"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU08197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="209" mass="23585" checksum="A05D63C90DC0C82A" modified="2019-07-31" version="1">MKKKNEEKSKTTVSPKDVQRDILDYINTCNRPVSIAEISINFKNEISKTILQKCLNSLVENNEIAFKLYNKTNIYVKIQSGVEVGNEEISKIENKIASLKESNASLKDQLKNLNSEISKINRLPDNITLENEISSLTKEVTKNSKKIESLKKGGVISKEDMVKVCKEHTRLKTLLKKRKDIFKNILDSILEGTGAKKSAFVEELGLSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLK7</accession>
    <name>A0A4Q9LLK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1655p0010</name>
        <name evidence="1" type="ORF">CWI38_2285p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002285">
        <property type="protein sequence ID" value="TBU08261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001655">
        <property type="protein sequence ID" value="TBU10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1655p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2285p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11140" checksum="2709667738E80526" modified="2019-07-31" version="1" fragment="single">MVKFIFPPSEIVTASISSLNVIQEFKFSIIDENRTKKNVLAFSSVSDENIFVVPYNGNIQIKFYTIEDLIRINRPLDVYINDIEKMSFIESYILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNF4</accession>
    <name>A0A4Q9LNF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2191p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002191">
        <property type="protein sequence ID" value="TBU09045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2191p0010"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17090" checksum="2E230F13C917174F" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQEEKIIKAANRASEVDEVIRECKNDQGIPQPSSYTPSTIINNISIPPSEANTNTKVCLLNTIPSPSNPMHSSTVTPRPDIAASWPNLCTIPISERLVVLRSILRSIEAERQEFIRCVLFAVQTRFDRMPRNGWKEIQSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP69</accession>
    <name>A0A4Q9LP69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2080p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002080">
        <property type="protein sequence ID" value="TBU09977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2080p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="449"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="700" mass="80192" checksum="E5C41377AC1A6393" modified="2019-07-31" version="1">MGRRKKVDSENIKNEEIKAVNNSEISLKKTKTCDRDVVTISETLPPQPTLHNNTHPPSSTTLYVTPVSLIDSVPPSSCPNSSACGPANTMENLNAPAIPEGNRLMVLHSILDLSQPFERMPRNGWSAILRYYNGKFGRTVDIDMLKKLTHNVAEREIRQEKNGERRRIATFLAEPCSSSDTTLYMKLREKFLYKIKEISEKEIGDVAVRTKKLPSELVDSKVLDLINRVVGEYAGAHVPESITEAAYIIQAAQVCYDEETRKENLISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLDLSKINDLSEALVKKNEALNVYEKKITMYESRRKFRKENLMFELFRGRFYRRLSEHVESEHVVHRDKISEFWSTMWNKNNKVVTYDEYLIPFVSDTQQTTFPSPEEFIDIINWLPNWKAAGIDGIYNFYIKKLTSLHKYLYDIVKVICLEGTPQADWYYCGLNYLIPKGTPKTGSDYRPITCISNLRKLLSDNQLGAVRGVQGAKEQALLNVAINKEYGNNLKATWINVKKAYDSIDHAYLRPEKIMSKKIDRGILQRDSLSPLLFVLCMDPLSRKLNEKYTKVIIQTDAESHATNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIGLEINKEKSATNDPCCEDTATLLEGIGVYKYLGIIEDSRGIPTSKSFEEVQTKIIARVERLCRTRLNARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPD6</accession>
    <name>A0A4Q9LPD6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_2061p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002061">
        <property type="protein sequence ID" value="TBU10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LPD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2061p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="714"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="876"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1287"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1288"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1319" mass="148745" checksum="1A8E17BE2F883986" modified="2019-07-31" version="1" fragment="single">TPLSTNPINNTPSFAPTSQSLVTLSALSSCILYNEPVLLIGETGVGKTHLIQHLSNINNKYLYIYNMSSDTDVSDLLGFYTSVHPISVIEEYVGNIIKREINETPLCYLERIERYINDNRETEGVNDSSKEEGVNDNRETEGVNDSSSNYKGVNDSSETEGVNDSSTNYKGVNDSSTNYKGVSNSTNNYHPFNNSTNNYHPFNNSTNNYNPLNNSTNYNPLNNSTNYNPLIPYINIPLLLNSIKECKILINKGIPHFKYQQGVMYKAMTEGKWLLLDEVNLSPKETLLFIDSIVERIVKSNCEGSGNNTPLSNSGINNTYNYSIDNKYNTPLNNSTCNTTYILPLNNNTCNNTNNTPLNNNTCNNTYNTPSNRHTTLYNIHYNPLLYNIHPNFRLFCCMNPPGIGKKDYKGILFSKIFMLDFTDSITDINILTHYLLRERNSKITPLRNSKLTPSMDSKLTPLRNSKLTPFYKGEEGNSNLKPSVDSNLTPPSLSCLTPLDSLPLFFFKLKEKVLNKELKGFYNKPLITGRTYCRLINMVNKGCCIYDSIRLVIYTQFNREGVNYIDSMVKGYNLYCECRLEGVSDKNDDYKGVSDKDMLEGVSYKNDDYKGFIDNNDDYKGVIDRSSNIKGVSDKNDDYKGVSDKNDDYKGVIDKDSNIKSVNTNTNTYHPLNNTNTYPPLNNTNTSHPFNNTFSLTSSNTRYIEILQLSIKYNLPILLQGPTCTGKTALITYISKINNTPLIRINNHNNITRADYIGTYQLINNTCTFIYGPLLHCMLKGCYLLLDELNLAPSEVLEVLNRVLDCNREIYVDEIQQTVKCSKGFRVFCTQNVMYGGRKGLSEALRNRFVEVTVEQLTLEDIESIVRGSIKGREGVGGVNDSSSNYKGVKDKHSNYKGVNDSSNSNYKGVNNSSSNYKGVNKSSSNYKGVNDSNCNYKGVGDSSSNYHPLNKCSNYHPLNKCSNYHPISNTTDTLHPLNNNNTIQHPLSTRIINKILSVYDSLRLYRNFNSLISIRDILRWVRRKGVSEEEVYENGVMLLFERQRNYMDRCVVKGVLDDVFRGVVRSRGVSNSTSTYHPVSNSTSNYHPVSNSSNNYHPFNNSTSTYHPFNNSTSTYHPVSNSSNNYHPFNNSSNTSFVLTPSYLRMYRLIYTAWINKEPILLIGETGIGKTKMLEYVSNLMGVNIETFSCNSNTQTHDFIGYYTLGKGSNEEGVSNSSRLECVNDKEYELEGVNHEEYELEGVSNSSMLEGVSNKDYGLEGVNDKGSNYKGVNVKEYRLEGINVKSPKQQGLNNSTNTLHPFSNIDSKQQGLSNSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ46</accession>
    <name>A0A4Q9LQ46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0091p0050</name>
        <name evidence="4" type="ORF">CWI38_2129p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000091">
        <property type="protein sequence ID" value="TBU04764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002129">
        <property type="protein sequence ID" value="TBU09665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0091p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2129p0010"/>
    <dbReference type="OrthoDB" id="2200886at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU09665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="129" mass="14611" checksum="9F8455E0DC6E663B" modified="2019-07-31" version="1">MAFYTKTIQIPIQIHPADLKRPEISINNTLMDCHLKYSYKLQGVLVSFTLLSFSKTGEMPYGTPFVKLLCRIQCLVFQPEIGEILDFCDGFSYGIFKIMCDGNTNGKCIVEDVIKGNDDTILIKGKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM9</accession>
    <name>A0A4Q9LQM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1554p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001554">
        <property type="protein sequence ID" value="TBU10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1554p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="51656" checksum="1FCB457D9BC3120B" modified="2019-07-31" version="1" fragment="single">PNNSKAEASNDPNNSKAETSNDPNNSKAETSNDPNNSKVVTDDSSNPKSFNNSDAARNTSKNTKKTKKEDKDNTNSVTKNSESLPTKSISKDTSNNTIIDFNIPKITNKELLNKKQEIESIKKQNRPIDLSIIYDYNIEVINMKKDQKKMVEKYKFLFIRVLREIEERKYLFQKSNSKQEIFKRNILIYRKDYKDYIDFSLLNSEEKSKIFNFLLKKFTRKFNKNDFDCEFYFEKCIQKLFCCYQETKEEIREVDDFIFRLLDYIDQHKMTCVYAFKQNVDLDEVHKKIKCIENGEYYNIKDVDICTNIYIMMVYLRVTIDGVIPLNLRKILLRFDVINSESKREYVLRFLPFIVGEKRRKIILRLIDLIWIVKSNFIEVEATDFMTRVLSECIFPLNDYRSNKNRIYACKIVKRLFDSDFYSISPRLYTNATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQV4</accession>
    <name>A0A4Q9LQV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1503p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001503">
        <property type="protein sequence ID" value="TBU10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1503p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="27600" checksum="94FB8222397150ED" modified="2019-07-31" version="1" fragment="single">MKWVFYILYEFFAQIETKIKTKVIEFNIIYAKDSDHILCENTGRNSSILFNQYGFRSEENNILKICKGVHFFSRHQFICPNRNGNKKHFKLTTIMISFPNNICLKPSPNRLFLISKVPKRIYLHQNLYSIDFKYCLKTFSDFDYMIANLTIYKFLDLIYFSYIIDIYKDKNFYKVLKSYMIHIPGNILYHGINQVILYKERFDSTYFEWIISRMLDAYFEVNFFCVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR04</accession>
    <name>A0A4Q9LR04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2064p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002064">
        <property type="protein sequence ID" value="TBU10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2064p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="80" mass="9781" checksum="6B5AE3D717262BFD" modified="2019-07-31" version="1" fragment="single">MENVEENLLNSEKRDSKYKQLTKEQRQGILEKLLQQMKENKLKHEFGMQHKLNTEKARYVPMFLQKRKKRCGRKPKEYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA1</accession>
    <name>A0A4Q9LRA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1652p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001652">
        <property type="protein sequence ID" value="TBU10606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1652p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41441" checksum="938A5AA0827B5638" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILKVENNNKSHLALIKGFLKVKYRLVEEVTKKSLDEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNKAVFCYIQDRNVFWGADGVCQHCGKSVRLCEKMLGHDYARRHNEVVRCLHLLLLNRYKFQSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRLDIFILDKKKNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVKKYHRSHLKRLEIPMNKASKQFPLIDEEDLKSWERASMDVIMRTEMHEEPNPPLKEEKRVEDGAKNSKPKNKAPFISQGGTTLEEPTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL0</accession>
    <name>A0A4Q9LRL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Argonaute-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1874p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001874">
        <property type="protein sequence ID" value="TBU10291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1874p0010"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="316"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="646"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119247" checksum="1AE200E61C0BCB45" modified="2019-07-31" version="1">MQLKNFPLPRQTSNKPSPLKIKANLFPIKLPPTLIHHYTITFEPPLHKSLTHHIFTTIVINNPSLFPTPLAYDSNSILITANELPFKDKTIDFIYKKKDTNKLIITHKHTISLKDIGLGLDNSSKDMLDNSSKDMLDNSSKDMLDNKDSKDMLDNSSKDMLDSSSKDMLDSSSKDSKDMLDNSSNNNNTNNNNNTNTTTNTSLAVQAFEIISRQHQLLTFISEGRKTYSSKFNTILSKGLQVFTGITHSLKLTLKGPLLNVDTAFSVFFEEISLLSFIIKTLSGRRSDKGNKYGKRYEGKKIKGDSREGDGKEGGVDIQLSREDENCLYNITPNTFKEVARVLKGVKMTTTHRERNFSFKICDITLTPASETFFEIRDNGGNDNGGNVGNGGNDNSGNEINNNNNNVINNNEINNNNNNNTTNPPTNNNTTNNNTTNNNTTNNTNTKHSVADYFASTYSTLKYPFLPCVVIKKRDKVLYLPIEVVRICSNQKYIRKLDESQTSEMIKIAALPPNIRFSIIKERIEDMNIFNNKIIKDFNIYYGKDFVEVKGRQLRVPDIQFGNKINNPVRGSWNLKGFTAVKPININEWAVLLLTDEEVRDINIYIDNLIRICNSFGVKLNKNYNIITCDSPKKYMEILSTGKYKFCIVVLKDRNSSVYGGVKKIAETVYCVVTQCIRRVNLEKCMDPTFCSNIAIKINAKLGGINYKLSSVGGGSGSGGYGGSSGYGGSRGSYNNSYRDGNNNSNTNSNNNSNTINNISTITSITSLFKGDTIVFGADVSHPGIGDLESPSIVAVVASLDTDLTSYTTIMRTQTRRQEIIENLKEIVREILIRFRSNSSVIPKRIIFFRDGVGESQFYSVFESEICSIKEACKSLDSKYEPEVIFIVAQKRHSIRFMIEDSSGEDSGNKGGDGDRGYSSSYKGDSSNYKGNSSSYKDNKPGNYKGNFKPRFTGNVLPGTCVDEVGHPLFFDFYLVSHYALQGTARPVRYQVLYDDSKLGVDLLQEYIHSMCYLYARATKAVSVVPPIYYAHLAAARAKCYIDNDNGGVIEMKKVCKGLENLLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL8</accession>
    <name>A0A4Q9LRL8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1589p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001589">
        <property type="protein sequence ID" value="TBU10716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1589p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="63194" checksum="59904F7312C2EDD1" modified="2019-07-31" version="1" fragment="single">DYLIPFVSDNPPTTFPSLNEFVSIINQLLNWKAAGIDDIHNFFIKKLTTLHKYLYDIVKVICLEGTPQADWSHCEHVCYDMKASNLYINHWMERLEVSKAFLEFYSPLSVSVLFIFRQKVCERKIVSGTPITWRRYDVSLDYVLSAKEQALLNIALNKEYGNNINATWINVKKAYDSIDHAYLTQCIENLNLPDWFLKFIKVRQEDGLSPLLFVLYAESHSVNHLLFIDDLKLLAKTAPYRINKEKSATNDTCCVKVFKYLGIIEDSRGIPTLQILCQSRLNDLVRAEFVKNKIYIPHELRSEYKIVNHKVENTNKDHLALSKGFLKVKYVLVEEITKKGFDDAQLGEFRNKIEKRKLHLKLYNVRKNELVSLTDGVCQQCGTFGKTVYHLATRYGIMECLETYNLLANELGFIYKCNIEIITYVMFWDDIQTKYHKGIHPLDGTLKDKTRYMRNRYPLLRAAENEEDDVKEFKTKDISPYFKSRNHIRVTDIKYKRRFGVGRRNNYGKIGRRKYMKMIKKSYNTEFINKMEKGELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ8</accession>
    <name>A0A4Q9LRZ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1263p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001263">
        <property type="protein sequence ID" value="TBU11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1263p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34227" checksum="9BB6EB8BA0F37516" modified="2019-07-31" version="1" fragment="single">AVFCYIQDRNVFGGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVKIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVETISFDRRRGLESGPSAEESWESASLSVIIGAERHKQPTPPLKEVKNQEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVIKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD4</accession>
    <name>A0A4Q9LSD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1425p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001425">
        <property type="protein sequence ID" value="TBU11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1425p0020"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1021" mass="121148" checksum="B28503AB52675D8D" modified="2019-07-31" version="1" fragment="single">KKDKITHKKIKKKNKSEIQNLLSEANIFYVKNKLNECIGLLKEIIKKSPQYFQAYYTLGLVYEEKNELENAFNCFYIAAHIKKKDYVLWKKLYEYTFILHDFYIKNDEYNKVEDKFITNERISDTHGFKSNPGLEITSTDRISEIYKERIYFISILQKKYNSPNKIKEKIDLYEILSMKDKILETKLEYIYFYGSGDIKTEGIYEKNSFIDDNFPESNSSENEEFSASNDLNTEFEYNSETNDKIENVSNETNTDFKEELIDQCLLLKEIRNTIKSNSELIRIIRKAIYFTCKCKNKKSISIEFLNSLISFSYELRDFKSLKNAFNNFAPINVKNIFIFFITFISLNRNPKCYFYEKTENINTSNSTMTNYLGNESATFKLENMEDNITNNNYDANRELKNSLDLFFFEKLMIFKESKDFLGFSNFYIIFDLIDTLFKNKNYTLSYEILEVLLQNNFTSHQINIKLEILNRMAGISISRNLKDDGIKFYLEILEILKNKKYFEIYNLKKEFSNEKLEVECFKMANGETKDAHDSNSSFINPMFPFIFNQDRIKAIVSNLYEELGNRDLALQYSLDINDEIGHFVDDLDQSNHEKKNEFSSSECKKIRSLFHKISFFYIENPNDDLERTLMFINTSNQLISDFMNNSYILNPKKYILQQSLGKVYDSNFEKSRLKSLHGLNVDEWFEVMKMNILCHLKLKKYEDSMNLLNRCLKSGVFKQRSDIYIQFLFLGFKYSLLNNNYGDFVNFVKKIVFYYQNASFYFFMYFFSNFFADYNRDKNFGHCQKNLQRLCKRVKENIGWPVSNTTMNSKNTLRNTSTESNNKNIQYQYKKSYYTNEFTSSLYSFNHPNTFLCLFLNSFLPRFLYSETVNYIENVTAVREKDIKTEIALSIIYFTHSKSRKINNKNHFISKGFEILKDLEKNDDYKDCSSNSNDSISIHQNKNLYNFYGCNGKCIIYYNLGRSYHTYGIIGFAEAFYKKVLKCKNAEVRKMAIFNLILIYKKNNSLNLVNEMAKLFNETAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK2</accession>
    <name>A0A4Q9LSK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1599p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001599">
        <property type="protein sequence ID" value="TBU10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1599p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6165" checksum="8F6011DD8DD2DB43" modified="2019-07-31" version="1">MKGNKRVSNKGSRISIIRVSNKRVNKGSNRRVSKGTVDKGVLILSSNISGVNNTIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY0</accession>
    <name>A0A4Q9LSY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1519p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001519">
        <property type="protein sequence ID" value="TBU10841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1519p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="48378" checksum="0EA421C380751381" modified="2019-07-31" version="1">MLDEIKPKEITEKLLNTNQEKIEHLRELLENVFIVFAGSFIQLDENLTDFSVYNSIKNKECLISEIKNNEFFKIINKIYSKNTWKLPESYTNRILQTPEKSKKCLFHELCRLMYVFTRKIFTFIFDNKELRLPDVMRNRSNYIFPDDCEDFPDDGAERKDILKETFGETPEISPFCDDLKPFLIKTNISFYIYKVEDSIFNDIITKFFEEKKISKKKFFKKLEESQLAYLYNEIENRKLHSKLYSTRNNELVSVCGPSRWLKKGSDRNVFWGEMVCVNEAETPVKLYIRRQNEVYAEIISDTRIKTDAKIRKYDLLANELGLIYKFGVEITPCVLTWNGIVTKYHKKYVKRLQIPINIETYIQSIVLKKTSEPNAEESWERANRKSYNKESDLEEDNEGVKIVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT88</accession>
    <name>A0A4Q9LT88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1034p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001034">
        <property type="protein sequence ID" value="TBU11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1034p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="34401" checksum="40453FCAC48DD011" modified="2019-07-31" version="1">MIGKIKNSGNIKKINISKVTKNQGLESSELIGILNKMNKSKQDIDDTVNIHRSIFKIIKNLKIKEEEEENLETKEEWQKVNLSFLENPALKLNETSICHHEYKRFPMLKYHMEYKFPIMVYKKNEYSFQSKLLNKASQDNKQEILFNNLENKETKAKNNIKYDLLNKSEKTKLAPFCNKKPLKYKSSHKDSIFGKISSIFKSSLKKILIIEKKLIHFLITLSVNVCYYEIRDARGTNIPLKEAKREEDGAKNFKPKNNTPLISQGGTTLEEPTNNINKESDLEEETAVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE1</accession>
    <name>A0A4Q9LTE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1142p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001142">
        <property type="protein sequence ID" value="TBU11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1142p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="95420" checksum="DE2E11C0FCBDF263" modified="2019-07-31" version="1">MNNIMYPKKKRAFKGYEFCIQYFILKIFMTLNLVTAYKFAFNFYKNENSEILFFLQRQENRENSEHNIEKFDLKLYNTNEENQFDRQDPVFTYTKENFIEFYLLNNMLLTNSFENNFQNRIINCNFDLSYYLKLSKDFTAIPDRLTICQLKYFLLTLKFLQAVDNKNLAKLLQALIFKVFICSNTDDTHKNDTKHEEIIDSYFVSQFDFYIKRGLLIAFLHILMIKYTFYDENLILLEKSKDTYNSSYFNEHIPYKNLLIYNYKIFRTLKNTLKGLPNFLCIFQILLDEINIKSLIINNYEKLENHIEDVYLFISSLTFFKSIAISNPNKNSQGFLYDPNFIYKEDIEYLSLKNLTVELSNLVFLLEQQKLKGLILDYVDLKDNGDYSMEYNMRLNLEYIHFANVEMNFFRWRDFFKFADFGKIILEFDRLLLQENVLSYIGLLNSYKNVLYLEIKFCNLYILRDFHKILNKFKYLQTLKLNRYIDDKNSSLYMFEAIKNMNYLENLTINLPYRGVYNNSDYFFGMQNFKVLCLTGTNLTQEIPNIKIWGNYTFLRNLIINKAIIKVYDLIEILKIESLTKFSILYCDIEPCFNYISVELSGINIKSLDFTATNLDALKNIDILKEFARLETLHLSNCNLKSGWLTQTNQSCNLSLKILHYAFNCLDRTDLNRMKNLEVLEELNLRDCKFYSCGFFELGNDCKFLGSLKYLDLLHVEIKIENLIFLKSFKNLKSLNLTLSDPDFFTAKNLLFYLPINALSLKECNKKSIFENSYSRYLYEENINLNLNSLSSKSFILIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH9</accession>
    <name>A0A4Q9LTH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1032p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001032">
        <property type="protein sequence ID" value="TBU11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1032p0020"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24611" checksum="AF7038AB6C7414FD" modified="2019-07-31" version="1">MKIIAITGGIATGKTSVANILMDKGYVVINADKISNKILYKNLEKVYQIFGDSVKNDDNTLNKVELRKVVFNNKEKRKELEKLIHPKVYAEIIFRLLYYAFMGKSIIFMEIPLFFECKLNKYFDSIVVYCDYETQRNRLIERDGNLLIDQKIKSQMDIKYKICNATYTIDNSNLIESTKIQLDKINFKGVNIYFYIIYILVLLMVYSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ9</accession>
    <name>A0A4Q9LTJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0967p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000967">
        <property type="protein sequence ID" value="TBU11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0967p0010"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="294" mass="33405" checksum="B03BBC5145578367" modified="2019-07-31" version="1">MLSTIIKYVSFYIFLRIVPDFYNFFISKLKNKIVWNKVKGKWIIITGATDGIGKELALNAAKRKYNIIIMGRSSSKLDEVYSLIIKENVKCKKIICDFSKECITSFINDSIEIGMLINNVGCVGEHPKLFGEESSVSEMINVNIYNTFLLTQKVLISMMNRKNGVILNIGSFTGDMPCPVLSVYSSTKAMIRSWSESLHYEMRPYNVHVECINTGYVATKMSKIKKPSFFVPSAKTYADSVLNSFGNSSVSITYFPHLLMYSVIKILPRTFLGIITFFSLSRTRNMAIEKKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK0</accession>
    <name>A0A4Q9LTK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0967p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000967">
        <property type="protein sequence ID" value="TBU11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0967p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="222" mass="26623" checksum="C1778E2A0104951E" modified="2019-07-31" version="1" fragment="single">MTESNVTEEINSRMHMRSTDICDSIPHIPQRKYVKEIEIEIGAISLKEKGRKLRGDTFFNSAESLKEFVKKNEFKVIISAHGCDGTLLNKNLPISRFLMNKIQEEEEIAEYKEIQNGVSKDDEEIKEDYENSNEAETNDEEKIQEDKRIQEERIEEEEKIQEEEKIQEDKRIEEEERIEEEEKIEEEEKIQEDKRIEEEEKIQEEEKIQEEEKIQEEEKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP8</accession>
    <name>A0A4Q9LTP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1451p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001451">
        <property type="protein sequence ID" value="TBU10975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1451p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24230" checksum="903C083AF57535C7" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQYIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKELDLIYKCSVEIIPYVKSPHLSLNVEAFIHIIVLKKTFETIFYDQGRRLKEPTINIKKEFCKRLFKSGNDFYLNFNKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU1</accession>
    <name>A0A4Q9LTU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1344p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001344">
        <property type="protein sequence ID" value="TBU11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1344p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="23789" checksum="2CB547E24A6CC47D" modified="2019-07-31" version="1">MLKWLRIFFTIQLSIFNLYMTINSVYLCAFYEDKEYDKSMLLDHLSCETDTHTNPSINSKNLMDESYMEFNKDIMETYIENQDTVSENASKESYDNKNDTDESVSDLLTVNSIDGSYIEHYDPSIETDRETHIENQDTRYKNVSKEGYNNENDTGKSISELSTDSIKSEILDQIYPESNLSSDISDERKRYKQENKIKWKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX2</accession>
    <name>A0A4Q9LTX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative BRCT domain-containing cell cycle checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0912p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000912">
        <property type="protein sequence ID" value="TBU12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0912p0020"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042479">
        <property type="entry name" value="Slf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057595">
        <property type="entry name" value="TopB1_SLF1_BRCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677:SF1">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23294">
        <property type="entry name" value="BRCT_TopB1_SLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="9">
        <location>
            <begin position="177"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="9">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="559" mass="66268" checksum="3E397CA77E4D7AF9" modified="2019-07-31" version="1">MDPKYEIISTQKQNIYITTTGISNIEIEIINSILPKNFILENTLSTSTTYLVTYKALFTEKYIQALKWEIPVIDVEWLYDTSQNIKKYYLLPFVGTCFTTSNVTNDIFKNYYKAYSAFYSPNLNISTDFLISSVDCEGEKNEFAKKYKIPIIDPENVFKNDFSLFGKSNNYTVLDIKTENIFENKIFYLESTLPSIIFNKLKRLIIENEGTRVSSIDNEVDYIITTKYSNIKKYENKNIYYQYIFDCVEQNILLLPDFYCIYNFEKYKILDETVCVVDKGLQNNRIILYNKIKAMGGRIKSRIDSSCTHFIVKNKKEFKKDSFRPYKVISFDWIDQCLYSLRFIKEDRYLVSRPTLNVFKLLKERENIKNVIYIETKKNKIFQFTGLAFYLKEKAIKMLNDFNIDYIDGDRYEKCTHLIMGSVSTSEKFLSCLAQGGWILKPNFIDDYDNSESFNFEKYEWSLDENFDENDKKIIASVKKWREKVLYEGKPAFYKWKVKLYCDDPKKESYIRVLQNGGATMTEADDYTHCFVDKKYTGKIKEHKYFSTDYIFSYLFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU17</accession>
    <name>A0A4Q9LU17_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1408p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PITK01001408">
        <property type="protein sequence ID" value="TBU11060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU17"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1408p0020"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020582827" description="Phosphotransferase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="222"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="48707" checksum="B61E3F6B96137FCD" modified="2019-07-31" version="1">MKIFLSLFLLYVKKSFLSNPDVKCLFTESAYTLIDMKKVAEAYCSYLIENYEDSKEKVCLKTKMKVKNFDESINKKVFAIDIGGTYLKICIVHFINNESNVLNYEKFEIKRELKTKEVDLFEWVAQMLNEYLSDKGEETTGIKEGAMTFSYPIKQDNCHNGEILSFGKDFPFRPIDLSEPKDPVKLLNNALKCLKIDLEIKIILNDANATFLSGYLTDSSTKMGIVLGTGSNCAFYTGDMVNDQIELINSEWGKFDNVSFKKSKYDDIIKETVLSENAVYQNVDYMIGGVKFIEIINLMYKDFTNTNKTISKEEIAQIRNQSDENNGNIENLELKKKICEYFKSRSISILASLVIGIVEKNNFKGKIGINLNGSAFNGCGEWKKLKEMLDELARSMEITDVEFSMSFNEHASLLGCAYALVCNPKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU89</accession>
    <name>A0A4Q9LU89_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0300p0010</name>
        <name evidence="11" type="ORF">CWI37_0450p0020</name>
        <name evidence="14" type="ORF">CWI38_0848p0010</name>
        <name evidence="13" type="ORF">CWI38_2077p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="PITJ01000450">
        <property type="protein sequence ID" value="TBU02582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000300">
        <property type="protein sequence ID" value="TBU03401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002077">
        <property type="protein sequence ID" value="TBU09993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000848">
        <property type="protein sequence ID" value="TBU12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU89"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0300p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0450p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0848p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2077p0010"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU03401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU09993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="253" mass="29004" checksum="5C44FB63EFAB31C2" modified="2019-07-31" version="1">MLYIIGLGLSDEKDISVRGLEIVRSCEKIYLENYTSLLKTNKAKLEELYGKEVEISTRNILEKTDLILEEAKDKDVALLVIGTPLFATTHTDIILRGKEKNVKIEIIHNSSIMNVMGCCGLFSYSFGRTVSIPYFTETWKPTSFYEKIYENFSNKLHTLCLLDLRVDEKEEKYMQPNIAIDQILESENILKLNFLNLDSEIFVVSRFGCPDQNIIFGKIRDILMMSHGNPLHSLIIPSKMEIIEKEHVTALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS3</accession>
    <name>A0A4Q9LUS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0900p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000900">
        <property type="protein sequence ID" value="TBU12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0900p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="534" mass="62139" checksum="0BB5482C4E807CBF" modified="2019-07-31" version="1">MKKNIIHAIKEYVIIFFYLQTIFSGTFSTNNFSRNLNDIAQNADVSNGNSQIASWEAYRIVDAKRKDTGSSDGSEFHTFESPQKKLNSDGNNNDTPQVKDLVNQLDTSDQSNPDSNKNDNSNDTENNENHYLSYEFEINEAMYLMSTILPLEYFNKLFNLQNQEPSSLYNMFNNIDSKTNEISGTESTLQSNIPVTNSAFIHTNPEIYTVANLSNQNDEISGFFDCKRLVLNLANISKSIKFAINYINVLNNSTSSVTTQINLNYLNKQAQESSIVGKCKKFYISTLKSWNLVIKDPNYRQDHPYLISFYCFLKESRNSSEKASDYLRKMCYWKLIDSYLKKEINSLDGIKLLGNYDKMTDIDLLTIEFLGVTQIVCKNRFLAFIKSYREDEGIRKVLDYSQFLIFFFQVKKFIQIEVNNGEKLLSPGVLEIRKKSTEIETFDILLKYLGNLYWFDINMLKTCLSEYKLAINSFIRHLNLRPHILKLKMDNCNDNPEDGNIHLKKRLQIFRDKFNEIRLQYLNMNKHWSLNDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV25</accession>
    <name>A0A4Q9LV25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0758p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000758">
        <property type="protein sequence ID" value="TBU12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0758p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="35820" checksum="55555147B9CA9254" modified="2019-07-31" version="1" fragment="single">MSRRKKVDSENIRNKKIKAVNNMENSEGEILMCDVDVEMLSDRLSPPPTFHNTTHQAVVARIVHQRHEKPNTDAILKGNRLMVVHTILDSVTVRFYRMPRNCWPATLRYYNEKFSCTLDIDAFKKPAQNEAEREIRQEENGERRRIATFLADTCTLTDTTEYIKMRDKFLSKIKEISEKEIGKVVVRTRKLPSKLYADYYVPMTITAVARIIQAAQVCYDELTRKEKPRSAWKENIESKISKLVLSKNLLEKARRQEKLSTSETKSLKKIMGEFNYNLSSVTDLSEALVKKNESLNVCEKKITMHESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV68</accession>
    <name>A0A4Q9LV68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0743p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000743">
        <property type="protein sequence ID" value="TBU12474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0743p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020483886" evidence="2">
        <location>
            <begin position="18"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="545" mass="64324" checksum="3034EC5D267DEFB7" modified="2019-07-31" version="1">MQKLIIFLEMIISTVFCTLESTVEDDIQHAQNQSRRCNFEVNRESQDMKVKIGDQHASNSGHGPKKAQYFGDQDGCDLFTSEPSTSQFEPSPRKQKRRLTNEKNSLRLLENPQRNITLKMKLENIEAVKNNFLKQLLDSKILKFTSENMNLPENRRYNPTVGYPIATETQYFNNIANIIDRYINRILNDRNLSFANLKGKYNSKDYSSSFLKSSHFEVIENVKKELVNIKKVNNIYDLEDIIAYSEKIRIFRIKSKKTFTKLQLQEMLTSLEIRNVKEELQKYRNIPSFYEFMLFKHRYADNIIDHIEEGCFLMLTENDLSKAYKNLSYKNKIDLEIQPLKIILMHIYLGLKNGLCLFKKYIIVYLLEFTHLFITEKILNLCINDDFGRNIFSLYHYIYDDSMSLQADLFLRIGNALAFLSLHNYHTSQDINLSFSKIMNHISQKSYIITLQAILRDIFPNCIHFSAFYPELFTNVGNFIENITLTEKWEDLDSRIKILFFKFCIKYAYMLRHLLSSDYHYEKMVLDSSMTQLYNDISSSFNEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK6</accession>
    <name>A0A4Q9LVK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1021p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001021">
        <property type="protein sequence ID" value="TBU11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1021p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14231" checksum="F5D85CB4ECAF419A" modified="2019-07-31" version="1" fragment="single">MKQRSTISKIEMYSEHTRSMWQHCNKPGKLVDHLTTRCEKMLSIAYTRRHNAVLLLKINLTNVETKKLRKYGLLANELGLIYRFGKYIQSILLMKTVETISFDRRRGLESGLNAEESWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM6</accession>
    <name>A0A4Q9LVM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PelA-like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1012p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001012">
        <property type="protein sequence ID" value="TBU11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1012p0020"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="350" mass="40744" checksum="55BA2BA30B32F608" modified="2019-07-31" version="1">MKIHKKYFDEKKLEGSIELMPEYPDDIYSLYNLIDKGDIIKSRTQRKIVVSNKNTERIYIKLEIVIESITVDLEANVIFFKGKTLTEHEHIKMGSFHTIEITLNDKLWLTKKEWNLLSLKILRDAETEYTEIFVVLLFDKECFVYSITQNYVKNILKQEIKNKNYKNIITFLEKANLKIIKSIIIASTSEERNIFLKNISSNKNIKENLEKFCSVKLDSDYSKMSGNKIIEKMMGDAVVLKKLHNVQFLKDLKEMEVFLTLFNTSSEYIAVGISDVQEGIEYGAVKSLLLTSEVFKSFDIEERKKIEKLILDVKAQNANLFVIPIRHFYGEKLAEMGGVAAILKFPYRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS0</accession>
    <name>A0A4Q9LVS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0662p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000662">
        <property type="protein sequence ID" value="TBU12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0662p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="415" mass="48978" checksum="114B06CE06E5DE8D" modified="2019-07-31" version="1">MHKHPRIDIRMIPIYFTAFVFFIINVKYIYSSALYIPNEIEWEVDNRKQIYIKNKSIASSSFAEVLLYEEINENISIAIKAQRLELHSYARELEFYEKLSDENIIQKIFSFKQDGIGYIAFKYFPYTLLDIADEIKNITLIDLKIIHKQLLDPLLYLEGEGVIHNNLKHDNVVVDKDLNIKIIDFGMACYIKDLYKVFKDENLDIEKLKEEYPHCSPERLIGADQNFKTDIYSWGYMLKTSSKLFVSQNQEFLYPDLIDIYEHALQVEVSARPSVDELIFHPFFDEIYNFLFCFNDYEDMKGNINNTLFDKIGNKILIRHSQFEFAIYCGCHNEKNDETVTRLLTTKIHSEKCTVCKTGFKISKYAKFKVEVSGQFFPIHILKMKYIKLIREDFLVFKSQIRLKSNPSIGLQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX3</accession>
    <name>A0A4Q9LVX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0722p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000722">
        <property type="protein sequence ID" value="TBU12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0722p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21500" checksum="F99CC0E26216789A" modified="2019-07-31" version="1">MKNENFAITIEKSNYITLIIQFKILLDKLNNIFSAEVNSQMSTLNLYDCEILKNSRLSLNRFKNLRNLELSASKQEINFYQLFDLAWGQILARIELKNFKIEQRDIIRIFLFKNLVFLKFSNCNFVENIQKCFKRKKGCCLKRLILSFNPEVNYKELSNYLFEEFDNIFSLEIYHPVPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW42</accession>
    <name>A0A4Q9LW42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0575p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000575">
        <property type="protein sequence ID" value="TBU12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0575p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="570" mass="66782" checksum="44A5B1FA511FE781" modified="2019-07-31" version="1">MERCKPKFLPFHLGPVSYKNGTFTFQRPDKLSPIPSFFPTVVKNATSIKFFGRMKTFEIISASSIIYSINNKEFHVRDIDSNKSYSFKVNEEVKSLIVTPSVIYLIAKNYLYTANQKVLKCIQMSNIIDFDFSEITNELFILTDTCISIYGEVRQRSTYAHYLPKPLFIRVLQHPRLVVVSLIRHLILVDLRSSTIKQNPLFKLRNLDSSIKENIELRNPKKGAKSKEKKKLEKKKSNVNKESEETKESIESKENTESIESNENKISKVSNENKESKMSNENKINEENTENRLNKKNKGNKANISNDLRKDTVEKNKLKKSDVDKTKKLKLMIPEYKYTKISKKKGFERPNYDFDKKNPIYSNLTVLMVFNEDITKINKYENGLYIFCFMRIYRIPDIRTGITFCDEIGVFLRNCKMYIGERDLIFYNKRGVFQYTSRNNLFDTRVCSYDIDGFAAFSLKNNIYGFLFEDKCIMFEEKNINHYNKYQIPLKSGHDYISDFFKKPRFGLDFIGLTRNYKTIYEDELSCELLDEIEGMIKEIKGTKKEEGVKTQEQPLLDIFYDAQSDTCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA0</accession>
    <name>A0A4Q9LWA0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_1148p0010</name>
        <name evidence="13" type="ORF">CWI38_0560p0040</name>
        <name evidence="12" type="ORF">CWI38_1625p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01001148">
        <property type="protein sequence ID" value="TBT99991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001625">
        <property type="protein sequence ID" value="TBU10657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000560">
        <property type="protein sequence ID" value="TBU13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1148p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0560p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1625p0020"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT99991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="353" mass="39722" checksum="C4AAEC79997CA631" modified="2019-07-31" version="1">MYILAIEGSCNKLGIGILYKDKILSNLRRTYNAPDTTGCIPSLIGVHHRKEILTLLEESLKVANITLNEISIFCYTRGPGISAPLIICATVARTLAYLYDKPLIPVNHCIAHIEMGRLITKMINPVILYVSGGNNQLISYKSENIYDEKSGEVIKKSKRYKIFGETIDIAVGSFLDRMARVLNLPNNPSPGYNIMKRAELSNNYIKLPYSVKGMDVSFSGILTHCIGIVENKKRSKTEDFDSFVNDMCYSIQETVFSALVEITERALSFIGCNEVLIVGGVGCNIRLQEMMAQMLKDRNGKLGCMDERYCIDNGAMIGYTGYLMYESGERFLKEECDVTQRFRTDSVEVTWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI0</accession>
    <name>A0A4Q9LWI0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 22">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 22">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CWI38_0858p0010</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26 27">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 22"/>
    <dbReference type="EMBL" id="PITK01000858">
        <property type="protein sequence ID" value="TBU12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0858p0010"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="23">
        <location>
            <begin position="148"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="21">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="422" mass="49760" checksum="DC333F873B0D264B" modified="2019-07-31" version="1">MDIEIGYKLPVKKDMKNGEIYQKAEILGIRKTRTGKEYYVHYTDFNKRLDEWVDESCLKIDNIEEIEIPKKKKKSVIERKVITKRKSIVTNKSLIQEITPNKVYEDERTTVALKKTPFRKEMSPNLKDLEINEEILDKNQSLATDESNKVKNVRKIRIGNYTVDAWYFSPYPEKIATSEIIYICQYCLFYFATQKQYEIHTKKCDLKHPPGNEIYRNQDISFFEIDGYSHKNYCRNLCLLSKLFLDHKTLYFDVDPFMFYILCRYENGYKIVGYFSKEKDSLQGYNLACLLTLPHEQKKGYGKVLIDFSYLLSKKENAIASPEKPLSDLGLLSYRSYWSEVIIEIIQNKKKTSISEISKLTSITEDDILSTLVAYGIIKFYHGYPIFIIKGEIFEKMIKGKKTRVNEHFLKWEGPVKERLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX2</accession>
    <name>A0A4Q9LWX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0483p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000483">
        <property type="protein sequence ID" value="TBU13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0483p0040"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="48"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="50390" checksum="BBC81001D3FA43C9" modified="2019-07-31" version="1" fragment="single">HKKNNDFEGFGTKYTFNKDYEPKNYNKRIFSNIIDIYNINNYELPEIEVPCELKGFFWILNMALDYKVIQNEFYYDLKNKIGDLKISKQINDDIHRTFSDNSCYRNIENVENLRQILETYNVYKPDVGYFQCMNVYVGTFRIFVNEEMTFWLLNYFIENVFNECYEKEMEGIYIYEIIINLFIEKYFPGLYKNLEKRNISISSVLSLWCISMFVQHLHFLQFLRIIDEIATKGRLFIFKFCLSLIKNIYVKLNRSKDINDAIFYFKEYFEKIKEDFNRGNNISFENILSSSNKEYNFEVEEFILFKSKAFIKYRDNCIREVFSDLSKKEKNMFLSKKEISLIYSKLNNLKNLNSENISHIFKLNKEIVEKYFSNENLTFIQFLYKINLLMNEITLTIDLHLKEEISCLLSQILNEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX40</accession>
    <name>A0A4Q9LX40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0487p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000487">
        <property type="protein sequence ID" value="TBU13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0487p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="15177" checksum="03B927E9AF8081EE" modified="2019-07-31" version="1">MLLNLIHLKSLFDVEKNNIRVFIRDFSHSSFLLFLKLIDNLDIIINQIKKQTFLDILIIISILDIKKSKERNELIKELLRSLLYGINRVSFDFDLDNEYINFFNYTVKRSIMRYLLVFFLKFVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX63</accession>
    <name>A0A4Q9LX63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0577p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000577">
        <property type="protein sequence ID" value="TBU12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0577p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="17685" checksum="DFA35A2AA45713F6" modified="2019-07-31" version="1">MNFSYYIYSYIFVFVCFYFDTKNIETKYFGYCGSRLHCDHTYAKSFTEATNEEEDGSFPQEMEENQDGNNLICFTCTKSVGSLIRKQQLPSKTGESSGNKQKDTDDSKKDILFARIISLKKNRVLNPKVRLDRIKGLETRQNTSEKTEDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX73</accession>
    <name>A0A4Q9LX73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0816p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000816">
        <property type="protein sequence ID" value="TBU12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0816p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="51430" checksum="13BE1BAE879176EC" modified="2019-07-31" version="1">MFINNERFLFFILENLVSVDNNLKNCLIFDKKNKQVEFCIKFYRDCHHNLQCKTYLKTMIFYLKYLNIKCLNFNPFLSPEKEYMGKSISDCNLKKYNHNFIFKDADFLMFQFQKINDLKIFKCDIVTVTSLLNHFKILRSLYIQNDIKESLDEEITFDFSILEKFKDTLKIIEIRYYHCFTNKDDINFAKLTMIRIHSKYRPNFEQNHINFLNKMVSNKRISDLHIQLCGIKIYKLIETLYDLNHLTSLTLLKLDLNESWGLYYLKNLENLELDISTLNYRKKFKNKEANKLKSLKIYFNQYFFADKISFFTKFLWEYNLPNNIVLTTSDTKNNFIDISSYEFHSLLKEVEFCKFIGFNIICRDVDLFKIKLEKMKNPKTLIFEECIIDLSSIYFFYLKKNDSLKIISYMSTYSMNYENNKKKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN2</accession>
    <name>A0A4Q9LXN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0399p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000399">
        <property type="protein sequence ID" value="TBU13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0399p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="392" mass="47523" checksum="0678505C4A1E3971" modified="2019-07-31" version="1">MILKKHEELLAKYRLKHFINGVQTQPFDESTKSKLIFILRFLTYIMKNTFNHEIYIIDSSHSNFFSSYDLDVSYHSLLFHNEYYYNISGVFNSLSYSYLKTRNFSFYIEKTFIIYSAGNEKEPIIDFYFNNERLNYIQVEIQKKLRYIIFEEKKTNIYDFKTNWSNVEIIYSNFLRYECYKYSDFQKLLSIEVLANVLIAKNLTIYNLELILFCIDLFLSKSAEDCLIESLYIFSSNILTINSHILEEERVIFHQNLIKDLFSKHRALSTNFKNEKYLILYNRLFIMLKFINKDLKIFNCQPFYEDRIDMTDIFTLFLNILYILHDELYFSNFVNIFFKSDTIKIYRTLFALIELKNKDALVVHEFMTKINIFVDYKDKIMLLFKIFFKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ1</accession>
    <name>A0A4Q9LXQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0675p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000675">
        <property type="protein sequence ID" value="TBU12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0675p0030"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="29284" checksum="62E6F625A6B3C5D1" modified="2019-07-31" version="1">MKFVAINIFSDNFSYLFYNDEEAFCVDPAEPLYIIDALSKSFDKIFYHKDEISSLPNISKPRKLVYSFTTHEHPDHAIGDDVIQNKIPSSIHKSLYKNTFKDNETVSMTEGTTITCLDTPGHTFYSACFYVQDISGLSYILTGDTIFFLGCGKIFTENPEKMVSSLDRIVETVKPDTLFLYGHNYNKTNVKFTEKVFKKVPENIQNKTFLTLKEEIEFNPFLNLSKCLPKGTKVDKMIYLRKMKDEFNREQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY13</accession>
    <name>A0A4Q9LY13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0699p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000699">
        <property type="protein sequence ID" value="TBU12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0699p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="841" mass="97927" checksum="D97C35FAA5ABADFC" modified="2019-07-31" version="1">MYPLVVFGIASLLYSNKKIYLDLRKCFKNWIPGIFILTYITATLFLRTNSCASVMDPSSLQFAFLNDFWKNKLFERKKLSGVKYWLSCQDGKKSKICLGTHHFKDNLSDESFLYSENDFNCSLGISLYHHEPLDSFEIDYSAKWNVKFRVLNNFRVLNLDKRPFIFENRLKVKYNEFCVFVNYLTLKDDMDSYMLSYKLFYKFLGMIEMLDPISSVFLNRLYSFLLKTGFLGADSDKIISDYKEYKTKYLDSKKHSIMYFFLVLDDSLDACLHREFSYISLFKKTNQLIDCGFRRIDHMSFVAMNISASTVEYIVKKFNREQLLIFNWILSCIEVSGFYFNKIEMTYAALIIPRVCDFGVEKLVEVERGSLHLVSPMFFELLSPTNIERISFFRFKSIMFSFDSLVSVFKKNTFKYFEISDCSFMKPQIISSLFPRKPSLEILKLQGIVLSNQDVVAILYLSIRTLVLNKCEMGTDFNRKTKYNDRVNYKILKSLRSLDISFSKLPVELLSLLLNADSIEKLNFSSFEFIPRGGFFKQTLFDVKRNWVSLITNKYIPSEYFMNVARSAESVKFFVLSQVSFEGCFRFFFSLHNFFDTVQGLDISGKIISIEIMNLLGGFKQVSQLNIANSLPASLVGLDKLNLFKTVEYLNVSGNIISSDDDNFVIKFRKLTKLDLSKTNLKDDALNEILNSGICDSLIHLDLCGVELSEKNYRKLCEFKLLKHLSIDFKKSLNVSQYADILKDAIFRENLNVFCVEAIEINLIDFFKLISFPKLKKFRLACYVFDESVRFLQRNNIIYVKNLRIEIVSMEALPCYIIEVLSGAFEDYCLSIVENMSVCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY68</accession>
    <name>A0A4Q9LY68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0602p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000602">
        <property type="protein sequence ID" value="TBU12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY68"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0602p0010"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="22986" checksum="A4B9AF0900384997" modified="2019-07-31" version="1">MDVPNLSYVREKPTPTQEQPRTKSGIMPTLQNVVATVNLNCKLDLKSIALRARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVITGAKSEESSKLAAQKYSRIINKLGFNTRFADFKIQNIVSSCDINFNVRLEGLAFAHNAYCSYEPELFPGLIYRMVDPKIVLLIFVSGKVVLTGAKLRDDIYKAFDNIYTVLRQYRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY81</accession>
    <name>A0A4Q9LY81_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0332p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000332">
        <property type="protein sequence ID" value="TBU13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY81"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0332p0020"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19331" checksum="6D8DD9FADAF08030" modified="2019-07-31" version="1">MQCICNLFIEKIDYKGQELAKKIMMIVYILGYTMSLIAGYTLGDLKYVLYGGIATVILVVLLVVPSWPFYLKEIFENEIKTDVNICKNRPKITFIKAGIKSQDSLQIVETEKPRRYDLLANELDLIYKYPNAEESWEERTISIKKVSTKEEGLNILKQKITHYFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY87</accession>
    <name>A0A4Q9LY87_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0595p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000595">
        <property type="protein sequence ID" value="TBU12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0595p0010"/>
    <dbReference type="OrthoDB" id="2190879at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15657" checksum="C4DDEC0332461505" modified="2019-07-31" version="1">MWNKNDDTVMWDDYLIPFVSDNHPSMFPSLDEFVSIISWLSNGKAAGIDGIYNFFIKKLTTLHKYLYEIMKVICLEGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQLKVERRGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC0</accession>
    <name>A0A4Q9LYC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0644p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000644">
        <property type="protein sequence ID" value="TBU12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0644p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="21314" checksum="27BB1902A89B55E1" modified="2019-07-31" version="1">MNFFYISTAPLFFISALLIVTALLQNTITLTCYKVLQRSKFFILPDEKSKILFLIAINLLILLIPLLYPSMIIEEENDYLEIDTRCSTNIFVVNIISSFFNVLSIVFKISYAFNCSVLSTFFNLLFAISYFFRRKTISFLFFNCVVVCNLFIFGFCFIKNSNIFYSYWFNQLKDVLTYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH5</accession>
    <name>A0A4Q9LYH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0432p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000432">
        <property type="protein sequence ID" value="TBU13436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0432p0050"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6288" checksum="900B09EEBA47FB30" modified="2019-07-31" version="1" fragment="single">KNINLDLEDLIKSHPGQKACSKILNVLIEQEAEPFITSPVNFHNLFKNKNNKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN8</accession>
    <name>A0A4Q9LYN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nuclear movement protein NudC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0284p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0050"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU17610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="154" mass="17819" checksum="B4D2EC904055CD63" modified="2019-07-31" version="1">MVANNYTWSQEFDDISITVEHTSNINSSDVCVEVINDILEISINKEIIISDKLCKPVINDEIVWEIDGNILVVTLTKRVKEWWESAFEGHEKVDVSKIAETRNTSLNDLDSESRQMVEKMLYEQKCKATGEKTEEELRNEELMKKLNMSQFEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZF5</accession>
    <name>A0A4Q9LZF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0330p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000330">
        <property type="protein sequence ID" value="TBU14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0330p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020311638" evidence="1">
        <location>
            <begin position="25"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="51158" checksum="BAEE91FB1F319B28" modified="2019-07-31" version="1">MVGGYISLFLLISAILCTKNPAKTKKWYKNDLLSIIHNEIYKQYRENTTIYDKICSYEYLLLENHKYFESEATDEILKFILAKKTEEFHIIFALIKSNKISSGFVFHVSIAIYDNFCIGIKFMNAYYEIPIKSIFSKIHSPSIKPHIKEYYIKKHISKFIFHQIAIFKRLINKIMSNRKNIFSVPIFSDTILFKNTDHDFISRILLRQEYNYENDYYLLINNLKINRRHNEFNETDNLNNILKYSFTNTIFKSIRNISFKRVEISDISKKNLPHKNYKNQIIAKEIYICNQIKYLNIYDIFLSNFQDDYEIEDKNNEYTNILGYGSANIDIVTFSKIDKPEKIKKSLQEYCYLIIRDRQINLEYHFEFTYKRYNNEIINISLNPTIPSFSADITLKNKISFILNFVKEYRKRNFSLVIWNQTESILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV8</accession>
    <name>A0A4Q9LZV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0284p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0020"/>
    <dbReference type="OrthoDB" id="2190329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="405" mass="48348" checksum="49FBC09EB2CDBA86" modified="2019-07-31" version="1">MIFSFLSKNLNFFTFHERKIKFIILIFTLYFSKIKRSEDSVLSKESLYCRINCIDSILMDYKDIEEVREGEGDCLKYVLNDLSDNQSIYIYIKCKNAKKYLKIFKSLQFLGEKFNILFKENEKFKVKNIFEKIEYFKEKVEDVCVSRENILGIKKDIDESNSKVVLMVEKVMKCMDDLKDDFTFCNYLKMVSSVRNMKCKVKNIKIILCSEILKKKGDSFLDINLCFGAETFVKIYPFLNFQCNSDILNMGKYFFESKVFYKFENKFNLSNKIDICLSEEMKSGKIFLCFLRALNNMHSHSLGSYFYIPFENYCVEMVSLFPFMVLNMVYCLVVYFFGKKKEFKFSYFHVLYIAYPFFPLICVFFLFSEIYLQGIMCVLFGVLNFSVGIIYNYVVFYKNLYEFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M006</accession>
    <name>A0A4Q9M006_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0405p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000405">
        <property type="protein sequence ID" value="TBU13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M006"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0405p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="559" mass="65610" checksum="0AD0CBAA5AC7F510" modified="2019-07-31" version="1">MFFYIFISLASIESDYDCIDILEDPTTKGNMYLEIPSSYSHNSDIFEHIMKINRDYGIKEYVKIIELASFYYDEIKKYTNESSHQFLLHFTTIICYIVYNNVGSESLKKYRPELLFNLISFGKFIEIYISDVEIESLVKEALIFCLFEIFRLKENVDFSKNQKVRKAIERFIDPKNILNSMSNEKLQLTFIKKNDNVFHNLGKELSNATFEYFFVFFSVLKSVFFANNYIVLRSTVGSSVTAINVDKSFQNSTKTAINILIKVINDFDHDKRLKILEYISKPIFKDVLKNQSELNTIFDFPRNRITSYSDPKVSRFPGVFIELFCEEADVNRINVLYDFLIEKTKKEYHRYISAVICLKAFCLKDGILKQNKAIRIIMEFIFLAKVLKIESEKTDNVKEIQKYRNTYIDAMKEAIGLQNMEYAINTDTSFLDESKVPRSSILLEIFVLVELFSNDSFKMFLDERINEKIFKEKKERFANDCKIKESYLKKIFENEISTLSSEGKKRFFCPPEPESPNPDPESKKSDGFGIKEIIFYILLPILAVSGIFIMGYLFLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M024</accession>
    <name>A0A4Q9M024_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0452p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000452">
        <property type="protein sequence ID" value="TBU13375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M024"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0452p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="45417" checksum="4FFB67E9F46979A6" modified="2019-07-31" version="1">MLRNGWPDTPRYHSEKSDCSLDISKRTLNERNCTCLAEPWFLTETANYITWKRNTCSVVRTRKLQSKFVNRKNVSDAARIMKSQDQSENKALRQIFSQFNLDLSRINDLSESLVKKNEFLDVYEKKLTIYISSIPKTSSDYGPITCISNLYKLAKKCVTKLVQIEVERRILLIDNPLGELYNEIKSRKQHSKVYMLEITSYARPRDDAVFCSNRDRNVFWGAEGIFNTATIVRCIHLTLLNIYKLWSLKRIRSHSVQEILDRACKGKKDTRIKTDVRIRCNRPDILVLDKRQNMITLIKKYDLFTNNLCLTYVKRLQMLMNNEAYIQAKVLRRQSKHFLSEPNAKESRESKSKTPLKQLDSEEDDVANEDSKLEDELEDVKIGREFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M073</accession>
    <name>A0A4Q9M073_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0152p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000152">
        <property type="protein sequence ID" value="TBU20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M073"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0152p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="24224" checksum="DF845684908F8269" modified="2019-07-31" version="1">MIKMWIFYYFTSFIILYSKIILSTSILPTGISVVESLIIPCEDAKPKPENLDDFINFQSNSTGSKIKVPKTVHSVPSTDDRSKPSDLGQKSTIDDRKTTFSSDFKIGNPQNNYFNFDPANFSEEIYPECWDLIFSAISEINKKHSLSTKDNEPHITTKIKAKNESKQAKTTETVVSGRIKKARRRGWTNKEQKGTRKRLSGECEIHKKNYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B0</accession>
    <name>A0A4Q9M0B0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0373p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000373">
        <property type="protein sequence ID" value="TBU13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0373p0010"/>
    <dbReference type="OrthoDB" id="2194576at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29459" checksum="882CB1240209FD7E" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHYKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLDHDYTRRHNEVVRCLHLLFLNINKFKSSKRIRSNAVKEILDNEYAEIRVNTRIKTDVKIRNNRPEYLFSKKKNKLTHIELALIYKFSVEIILYVMTWDGIVTKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D4</accession>
    <name>A0A4Q9M0D4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Sec8 exocyst complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0371p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000371">
        <property type="protein sequence ID" value="TBU13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0371p0040"/>
    <dbReference type="OrthoDB" id="2193852at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="761" mass="90784" checksum="B8F8B102207672CC" modified="2019-07-31" version="1">MDDIPSLIRELRVDWEKTLDEDFNPLPCALALSDSDSQKSATFKDMYHKLDETMTNIIEKNYQGFSDFVLLYGHAFKLNQECYNTLQMIIKDCQIIKNTYSEDFSHLSKEKRELLDQKKILEIYKALDTVKNISNFLNEKIERERFQEASTDFLNIYDLTNEYDLKSLKCYKNLSDDIISLKTSLLNNIFKKIKKTIFSGEEVIENKALLQKEDLEDEYIDTLGCLIRLGELKELDIYFYKNFSNFFFEDMQKIIYSCMESDDKVTCLVKKSVLYILNILKTFEVLISLIKNIDKTNINLIQNQENYFEVEIDDEYHFFGKNGIIKLEDILIIETKKFLEFYSKIKDYDQPESIFSLDNVLDTVDYSSIFQKKYAVSKRMENNSKHDFKISYNKYFSIFKPTPEVLFLFYENIGVEFPKLKENIRIYITEKYIKIKDKELSSKINDIILSEHAFYCDFKNQKLIFFEKLVEIVKKWCNEMKRIGFFDNWNVINQIFVSVLKKYKECFLKIFKCNLIIKSIFKFDSNGNIDENIILERNIRNEINEKEEGIDKLTRFLMIKSIYKEDLIFKKNEYLKILITIDTFNKLYDLYKETIKGFEKNQVIPELEALSHEFEATVKIFILALNFELIVESMYFYIIFFRECTYDDSCNETLQKIFDIFKEIKNAFKIVQINLDILWCLNPILEIFSKYSIRYVRYLNVNNLEDLNVYIEKIELIEEIFYGLGSTTGMTEWLNILKSTQNNKSTNEEEKILIDKISRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M2</accession>
    <name>A0A4Q9M0M2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative PI31 proteasome regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0346p0060</name>
        <name evidence="5" type="ORF">CWI38_0415p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000415">
        <property type="protein sequence ID" value="TBU13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000346">
        <property type="protein sequence ID" value="TBU13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0346p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0415p0030"/>
    <dbReference type="OrthoDB" id="2196290at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="29837" checksum="48A319D8DCC44DBA" modified="2019-07-31" version="1">MDFDDFLKVVEKKFTVQEIEKDKFLITGNNRSYLLSRSETVDFDKFMEFFEKSLPLNQKEKPEDLNYEGLSFIKSKSENLETLSSNRYDFDFSPNKSFSRVGENDLYPTGFSPYGSFFRPNFYSPKGGMFVTEDDELFRSRVDKSKKDDEEPTPDVPPLARFDPFVPSKDKKAGANPDPDNLKKPGKKIAVALIAIIAIIVVIWLGVWAFKKGRSNKPDMNTGKDSNKTKSDSDKKAGDDTTDWNAKKVVSDGKKTVKSRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U9</accession>
    <name>A0A4Q9M0U9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0101p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000101">
        <property type="protein sequence ID" value="TBU20259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0101p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1106" mass="124443" checksum="5DBA6CDA9E800D59" modified="2019-07-31" version="1">MKFLIPIPSSPVTKRIENSLENRNFGFLKSINYSDINNLIAYADINVVKLNKRILNMNKINRLGLFLKGKCAYKSFLGLTKAVLTLFKSQINAIAYMKINNGFENKTFIVELTSKDKEGLFKETLLNFRFDNDSRKYTAVDYITFFLFSCQVSNYDFVFPSEDRPVGSLNVELNHLRNIPGVSSDLNIIDVTSNHSLDENIRIQDQILITHMNTGICMEEDLRREVPSFNNRSYEISTLEFNEMTHTTNQILEIDNTNNSITLQTFSDTASALKSVEESFTISNPIATNSSLPENSLKTSADAISLSSNDIKSENVLNPLNSEPILISGLESSDPLLSVDITQKVDFKINQTSLEIATEKKHLDEPLDDMYSKITSHREILDIRAITPVESISHEDLPESNSQNPESFEFGNVQKKHMISPKRIFCGISSLNRQRNSEETEISSRTLKKFNRLASSDTIRSIHGMPNQNIAENSSVECKTNSTSFQNLRQSLNLSDDPKSSLIEKNNILSNTSENIAMEKQIFTNKDAKSGLDTTTVEIFCAESFQDRTQGDNTSPSLTLFQEELASDQKISISDAEFQSSNSGFNADSVSQVFVKQILCSRPHFDPASLDASPVYQEEHYSSIQTTELNTKPLSIETSQSKLNYPVGENVSIRCSPLSNYPDSQPFGARNKYPQYEKLHNINNPANTPSEIDEVCTEENQSYMHKSNDSGFKHILTHSTAAKSYNSQNTEVDLETDLKDDTGLERTDLNTEEKSLSNMSSVYSQIDMGKETQTGCLRNIHGNLSSEEYGIETQSKFDPVSFQLESENESLIDAILNSSSEYEKHTPKKFYKEISFQKINEGIVLETSNQSNYGKDAPQKSTEYSEIQDSKEIIEATKQVSPNPIENRSDENFPTTPFSTQNQDVKSKKMSCHEEIEIELFDESIHLIEGASALPEEDCTGQANIKVLLDYQPETTSCELFRLNESYMDDAYLNYSDEDSYTEQFNSYSSLTSESKHYIDTSPSPKIGELSAIKEENEESSEDLLLPFGSNKTFQSTANESTSNSEGRFLDSHSISSIQTQAITSSNLNLDLDAHQIPQPYEENTKSNNPTLSEENTIDLLKNSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z7</accession>
    <name>A0A4Q9M0Z7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0098p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000098">
        <property type="protein sequence ID" value="TBU20275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0098p0030"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="85928" checksum="69C61304948E0475" modified="2019-07-31" version="1">MRLLFLIKLTFTFSQEFTFVFAKRKLNNIKCLKIEESIGLFDGLQNFKDILNTEIKTNFSYIDENSLEKIYISKVDIPRYIILSSGFFGAYLDSPLNKKPIYLTNVISLKGFDAFIFFIQCHSLEVYILTQNIFHEIFICLDYLQIHETLKNSYFYVNLIRSLVASKINFDTREIENLFLSLPNNFLIQNFLILFSYLISSINTFNPINDIDCENFKLINKTIVSKDHDIVSIMKNVENIWYRNIFRQFICQLLSVQIKIYIMDFHLYKISKLKLFADLFKVKELHIEGYYSYIFASYLLNGLCKNTLSTFFLCGSRITECISLNISKLKKLRCLFLISCTEICLSSIMRIENQNSLCLKRLDFSRTNITEKEIRQIFYLHSVERIEMCGSNINQGIISLLRDCNFKSSLRYLNLGNNILNGEDISVIFSFPNLYHLDITGCRLTNSQEIKPYIIDCRNLKVFYMTYVNLNKNILKTLNYFLSLEILSMYLVVYNGVIFDEVNTSLIDQTLIELDLGQKYLTLSDIQKISQLKNLKKLNLKRTIYHNCKNEMYENLDLPDNLEVLELEENDLKDGKLFNFQNLKCLKVLNISLCNLNSLEFLKKIPFLFEKLEKLSVAKNTLSLTDLNLLGKFQILNNLNLSNTRLKNCGISILINSLVSNTLEHFDFDENELSYSDFLAQKSFKRLKYIRLFGCKMPFRHFTDNDILFLKNTCSIEYKNISYKNGYIIFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G8</accession>
    <name>A0A4Q9M1G8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_0952p0010</name>
        <name evidence="14" type="ORF">CWI38_0058p0050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Water channel required to facilitate the transport of water across membranes. Involved in osmotolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000952">
        <property type="protein sequence ID" value="TBU00612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000058">
        <property type="protein sequence ID" value="TBU20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1G8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0952p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0058p0050"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU00612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="253" mass="27195" checksum="FFE508F33B56CF50" modified="2019-07-31" version="1">MSLTFKWKKLQSYLAEMTISFGFGFAVYSAIIGSTLTEQPSTPVIVGLTVALSSVALIYTFVDITIAHFNPAITFAAIVAGKIHILKGFGYILAQALGFMIAAAVVLGCFPGNVSDLLEIIRPKKVSSDVTTGELICTEMFLTGILVFVAFSVAINAYKKPVFKEDREFLINPEPVDTTPDKSILAPLVIGLTLGFLAFLGISSSGGVFNPGIVWAPVLFTGNWVNSWAYWVGEFVGGTAGGLLQVLFLYRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W3</accession>
    <name>A0A4Q9M1W3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0039p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000039">
        <property type="protein sequence ID" value="TBU20655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0039p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15992" checksum="68108DE8FE6272D2" modified="2019-07-31" version="1">MNMLNENISVIDTGAVDIELNNEQNINRHIYPENNLDNNTESDKNRSVSCILCISEIIIGLILVCMMFLRFRYSIKPNILMVFNILLKILFGIFFILENTNVKRFVLKGISIYNLVLFGLVLFDGGILIALCYLDYYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z8</accession>
    <name>A0A4Q9M1Z8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0219p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17325" checksum="82F000AF4C842B1C" modified="2019-07-31" version="1">MKFEDDIIYGKIGNIESNVVFSLYLVQNLTTLRNLKTFNSIIGVSSQKSKYKSFILILNERLNSYDRFVIFTEYFRDDGKNFDTGYISVMISQKYSVNILNDTVCYLKNLEDCSIFAKLKLYFLNYKNRIDFSDPDNNPLEYTLYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M207</accession>
    <name>A0A4Q9M207_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0152p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000152">
        <property type="protein sequence ID" value="TBU20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M207"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0152p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="7733" checksum="0EE282181778AF6D" modified="2019-07-31" version="1">MSFIGPGEGAVFCYIQDRNVLERATCVCKHINPMMVFGKKTQDRILLISDGNTTVEELTININKESDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F9</accession>
    <name>A0A4Q9M2F9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0118p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0030"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="379"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="949" mass="109557" checksum="88976420CC8F4B87" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSHTTTTHPLLIQTCSNIQNSELRTIPSPNTPLPSSVEVSVCESSYEMTNPCNRLMALRTIFIPQQPTRSNGLELFFLQMSRNGWTELHRYYNKKFGYADSRSEVKLEENRERRRIATCLADTCTLSDTTVYINLRDKLFSKTKEISEKEIGKLVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATRKEKPRFAWKKNIESKISKLVLSKDLLEKARKQEKLSTSESKSLKKIMREFNLNLSSVTDLSEALVMKNESLNVYEKKIAMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDKVVMYDDYLIPFVSDNQAYYRPITCMFNFYKLTTKCVTKFVQLEVERRGLLAENQLGAVRGLTQCIENLNLPDWIMKFIKVIISKWEIDISVGPEKIMSKKIDRGILQGDNPSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNLLLFIDDLKLLAKDSSTLRAMTGEAKEFLEVIGLEINKEKSATNDTCVSVYKYLGIIEDSRGIQTRSSFEEVQSKLIARLEDAVRAVLVKNKIHLRPGYKDRLHSVELRSEHMLLQRLDCLEKSKEILTRRAAILKVENNNKTHLALIKGFLKLKYRLVEESKLYNARKNELVSVTKKRNIRPRNEAVCCFIQDRNVFWGADNHLTTRCEKMLGNAYIKRHNEVVRCLHLLFLNRYKSHSVQEILNNEYAEIRVDTKIKTDVKIRNNRPNLYIFDKKKNKISLIEVGITSQDLLHIVETEKIRKYDLLVNDLCFIWQCSLEIISHGQKIQITMNIEAYFLSIVLKKTVETISFDRRRGLEASMGVIMRSEMHEEQTPPSKEAKKEEDGAKNLTPKNNTHLISQGGTTLKESTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I0</accession>
    <name>A0A4Q9M2I0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0010p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000010">
        <property type="protein sequence ID" value="TBU20909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0010p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020753454" evidence="1">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="52064" checksum="5FDD147CD2B8A584" modified="2019-07-31" version="1">MHMGVNFFRANLLLVCMFATFLVFTHDINKEFNIDEYRDFFIKKSLDLYEKESKQFKNIPKLIELIDLMFYDDHLGFAVDSLSTFFYSKNSKKYNFDIYRPDLKTIFRYEPIKIRGFEVVRINDKIWCINSIKPTACADVNNRLGRNFKIINEKIFKAFLINFFKMYKCIRKISKFYDTNENSYVSIEDITNNTSKKIPRKFQKTDSYLFPYLCNASSVKIESEIETVDLDFERAKMIESFEIKFGKFSYFFYGYYNLYIIDRDISESYEGSNISKISKKTTISLYRIDFLDPMPLDHYKKVTFPVERTYYYESSLQYIKFEYFHTKYSVNHDNYQFLIRFTDSDITFEFNFNWFAACELIKNYTPATTIYVYLKIEGDRNLEIVEMKRCIDKNYFRVLNVLDFHSRIGLFYNKNIKELNEDIDLKNMFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P7</accession>
    <name>A0A4Q9M2P7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0005p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12905" checksum="EEDB715C29A7FD4F" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3I0</accession>
    <name>A0A4Q9M3I0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0026p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3I0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="20152" checksum="98E1EE94C4C6B748" modified="2019-07-31" version="1">MESLILNFKILQKLENLFLKFVSNDLLSLRIEHSCFNECNRGVLKKFVEVLDLQINDCTFKKISFHELFKPYIEYKLSAVGLKNINIKIGDMIFLKNLTNLKELYFSNCNFVNKSYLYLTKLHFMLLTDLSCDSDSENFIDPDFKEVISFLYTEFTSRVFSRGGILFFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Y3</accession>
    <name>A0A4Q9M3Y3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0030p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9M3Y3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0020"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1300" mass="146531" checksum="55EA6A57EBAFE93D" modified="2019-07-31" version="1">MQQPPPQNHPLNVLIANLSSSTPDPYLLQLYERIKQYLKENGSKLFLTEYVPLLLQHPFCNVNTYGIHAVNELFKILQYLTPQHTDIETLNLLRWTNHYTPLNKYIINTSNKDILKGVNYKERETNMKECINKEIIEHKPVPNPTPTLNNCINKEILDNNYEGVNNLDNTNPTLTPNDCINKEILDNNYEGVNNLDNPIADECINKEVLDNNYKGVNNLDNTNPTLTLNNCINNSNSQNEVITGILLLLQQFIPFNIKQALDLYMYICEHYNINYTSYLTNYPSLYIDTLLHRINCILNKSPGINTLYLQSLSINTLIDKEVETNVKEFVSNTPLTNSTSNNTPLTNSTSNNTPLTNSTSNNTPLTNTTSNTTSNSTSLTISTDTKTPLNNSTVNNTPLNNSTLINTLLISDLSTVKHFIIKQHLYFQTPENKSNFSIPPVNNTYSNIFISSNDNKGVIDTPSNSNHIYINTCYSQVNNYFEFSNNYKGFNYNTDINNYNFITETVDLEYSTVDIDSNGNPRDNNNKGVDNSKDNGYNNDSDSGYNNNHTNPINTHNNNNNNIANNLTCVRQLLDKITTYLSMFKDNTLYNIYNNYCNANTSNKIICAKYLDRIYCKEVLKGVNSLIESDIEICLYVYKSIWNRCINNKGILGGDNDSSRLEGVNNSSSVLEGVSDKDSVLEGVSNSSVLEGVSDKDTVLEGVSHSTTKQQGDNNSTNNYHPLINTPSNQHPLTNTPNNYHPLTTYHPVTSYISKEYLKSIYSIITPSIDIPVNLLINYVKTTVNLLNSPSSSVNECIPLAGCYGYFIKYYNIKEMVMLYVCMYWMWGDKIRSVLCKWLVNVVRVIKESENNSKFKGKESKYSDIGEGGVNKELEGVNKDEEGVNKEEEVIKEIEGVNKDDEGIKGLEGVNKEEEGIKELEGVNKDEEVIKGLEGVNKDEEVIKKLEGVNKEEEGIKELEGVNKEEEGIKELEGIKGLEGVNKEVPFSDKEVPFNNNTTEEIPFNNTTEELPSGDNTFNNTSTVPIINTLCSLPSIKEALGNKSKDKGLNELKVDDITVIEGEDNKGCYNSNDILGNITPFNDETYNTGTSSNDNRLLDNTSNTLLDNSINLLDNSNDNTLLDNSINTLLDNSSNNTLLDNSSNNTLLDSNSNLLGNSNTLLNNSISNNTPSIYDNTPLNNSTNYPYLISELLSGLSVFECTSLSLKRIITDVSVSNDNIRKNFIGCMMEVLNYYEEEFKVIIIENMLNNSNDWRYRVILMLKVIETMGVKGLSLVSKLEKDKVFYVRKVYEEIKEKYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Z5</accession>
    <name>A0A4Q9M3Z5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0009p0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Z5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0170"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="291" mass="33381" checksum="690C1FEDAA1D6CB7" modified="2019-07-31" version="1">MPLENVNILRVNQGIQSFLFELSLCGFKIDNATDLKCLIRFNRVKKLDLSDSPISFNKTGIVLLPDETYLPTSLEVLILDNLKFSSSSIIYLVNGLKNLKKISMKGFKFHFLQIYTSFFEILTQIEEIDFSNCDFDNISPFIFQNLKSLIVLRLFNAKVKKYSDIWEFLNSLPRPQGVTDLSLGNVRFYTPSIIKATASTVVHKSNLTEVYSFFQTKNSLKVLSLHLVVFEKQSISRHLLECFCQLDHLYVGYDALSEQSEQLNILKENVPPHVLKIFKCTNKGSDISKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M425</accession>
    <name>A0A4Q9M425_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0026p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M425"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17602" checksum="B4E7732EA5004273" modified="2019-07-31" version="1">MLGDDLYFEKRERITKVVVEFEEILIRHIIETEYSVAHCGINKMIALISEKYYRIPKVCIIESELKYNLVFVDEISSNVLTSRKNDPEYTQWNLEIASELYNEFNEPRYLASPSTNTASEIDKNIENNTKVCKHFAKILKKNHRNIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M427</accession>
    <name>A0A4Q9M427_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0096p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000096">
        <property type="protein sequence ID" value="TBU20286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M427"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0096p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="26313" checksum="B3595754BD68DF65" modified="2019-07-31" version="1">MFPEIFKNERIFLHFIHNGSQPIVPFDIKIRENSFIDPIYTKEDLEFICNTFFHHSLRTLYLSFYFRIENWLFIFGEQLLLTLGKEDFFAAMRNNISDRKVIRKRQTTAFFKNVFAKKRKFCEEIGTFFSTLKSQIIESPTYAYFYIYKVQDIDISNIPKEIFKKYRIENFVSNCAGKHPFASLEKNLFIYFMDFLETTIEEQLTGEPIKEKKVFWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M434</accession>
    <name>A0A4Q9M434_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0023p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M434"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="48663" checksum="E5B9C8A9EBEB9CBF" modified="2019-07-31" version="1">MLFYWYLDNILIFLHFISNTNLLRGDIDTSKKYDLKILYNEIELYVDEAKLEIGLFDKFSNGFSVFVADERIDWHELNKMIKLNFLKSMQSIYLKRFLLDKKLKSLEDICRLTKKMFKTSQKCDLQTNDHRNKLTEKYTDLFEFQSYRCDTIANSNIKAFYLGTLKYLVTHLMDDDSGIFDQKDLLEIFIISSSNLTTIENAAINIILKFCLDKFLSVGGVVYIFVNKVPENFVQTIMNPNFTRIDISHFYSFKIHSTFTEDSQEKIVFESFKSQDISNKLYIIGLDQKKIYMKKRDMNFNCKKYDLLFFNSVSVIMNQEIGKYEKKIYKIFDKDHKMIYKVQFILWNIGYFIVDFEIYEKELKNKMCLQIKEFNNEFYFYKYKILFDTDLNIIYHRREECEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M513</accession>
    <name>A0A4Q9M513_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0037p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000037">
        <property type="protein sequence ID" value="TBU20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M513"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0037p0050"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18852" checksum="15CA10CC3471EF72" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEIGFKETKTCDRDVVTISEPLPPQLTIYNNTHSRSSNSFRPANTIENLNAPVISEGNRLNVSHSILDSVTAVEQEWPRSVIITVQKRFERMPRNGWSAILRYYNRKFGRTVDIDVLKKLKQNNAEREITQEENRERRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5Z8</accession>
    <name>A0A4Q9M5Z8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0003p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5Z8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="796" mass="95591" checksum="3A09D2C1A2785488" modified="2019-07-31" version="1">MLTDLQKYFSNFNCKYKCFFNYIIRYYVQICIIYCHLFLLFAVNSCICGIEINVWIINEKENIKTSTNDVGCYFLQEGAYSTLQNCDRAIEGENHTETTSPVLYSCDNFLKFGFLEGKIAEKQTKISIYTKIEGYFDFLYFLKITQSSDNILLLELKMFFNILRYLKVLNVERDKNYCEFIKSMVFCVKNFNEEYFVQSGLSAFLDYKHFDNFNIRDVLECFLDFHMFNEFIVFKTFHDYRQIQFINSKNMQIANKEYKYIVTISLIETNFLPYLHIMSLFPCHKWRILRRLLYINRLYIGDIKDVHNSFDMNKFVYLMPNNINKAIIYASYNMSLIDKLHISGFFKMVKNIKLIHHSSFEPFLPKMHYFKNTEILQFDIFSLEMHELNTIENLDIIRDLKMFKLIVSRIDYMKHRTPQYFLNGNKHNIFIDSSVKNKISNSQETYRMPIVDGYYKYLYGADLHFYIHTYESFNFHKFNLERIKRLKIDLLKTSGNRLKNYEFLGLFKSLKKLYLANIMLTTELLSIILRCNRLTSVCFYKFEDNNFLDDKCFNFSNSPIIYFEFKASKNTLNPKLFHFIQSCKFTQSLCFYEVYILYIRRNFPPKTENMSESQPLSSILHRPKLKTLKFEVESKFANINFHSSLNIFSMFYNIADLERLSYYVFSLYQDDLEHFSNFKRLYFLELGIVQNSPELNIFEKLINTNLLNTLQELHLNVNIFYNFEFTKLFIFRRLKILLIGLPSKAMNLKNYIHSFECKNYTFLGLYGVLDFDHISSFRYSCEIIYETNRTKKATMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUL0</accession>
    <name>A0A4V2JUL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ran GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1045p0010</name>
        <name evidence="5" type="ORF">CWI38_0484p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001045">
        <property type="protein sequence ID" value="TBU00312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000484">
        <property type="protein sequence ID" value="TBU13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUL0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1045p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0484p0020"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="354" mass="40374" checksum="19D7D526A5EBB24B" modified="2019-07-31" version="1">MIISIENVGKNYETKGDISNLLASIKEYHEQITEIILAGSVFKKEPLEILFVLIGSLPNLKKINLSRIFTALPKDLMIESLEIIFKYLKPENIMSLDISENALSCNFPPNFTSFLCNMNCMVEFKINDCGLGTIGGAKLAECLLKISDKSNLRNINISQNKLTSSAVELGNALEKFENLEEIRIQYNNIDRNSMDVFLKSFKNHFLSVLDIRDNFLSLEGCKILGEYFVDRDIVELRMGDCLIRDEGIKEFLKVATQKKRYFALQGGFEKEYAPIKLDLSYNDLTDEILDDLVKFIKEWDFDTLWIEGNEFKVSEELYSSVRSKGGKIIGEEDSVDVSGDELENSINERFNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUU5</accession>
    <name>A0A4V2JUU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0711p0040</name>
        <name evidence="2" type="ORF">CWI38_1523p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000711">
        <property type="protein sequence ID" value="TBU01432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001523">
        <property type="protein sequence ID" value="TBU10834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0711p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1523p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="203" mass="23081" checksum="B5E8173EEB754442" modified="2019-07-31" version="1">MILLTGMPLERMAIGRKHNGVKILNMESLINNRNYRFVAGIHGNSKTGYMIHIGKNFLKIDKDGYVVGTRFENDANLFDIEHTKFGYKIIYNKKCVTKGTETGTVFLSDCFDDGSHNSVFQRFDFISLKKPNNSKALSKDKMCKKPEKNTDISNLDVNLEQKFYDSIFDKNFSSSFDFIVSLAKCRGNDVDCICLKAVNNPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUW3</accession>
    <name>A0A4V2JUW3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0642p0020</name>
        <name evidence="9" type="ORF">CWI38_1883p0010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000642">
        <property type="protein sequence ID" value="TBU01722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001883">
        <property type="protein sequence ID" value="TBU10277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUW3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0642p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1883p0010"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU01722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="280" mass="33777" checksum="EC074865D9553F54" modified="2019-07-31" version="1">MEECMKECFIDLKNSTSINYLERLLGRSKNDKIATICHHNCSVLLNINDYKHNGRYPFRSILTSTEFLSSVFSMFNFIMIFICYNLIFSNNNKSVSFTGLYKLQYIISLICWISSTLFHIYDTWYTRCMDYFTGYIFFIVTLYIFTLRSLYLFKFNQKNIIFFRNYMVPLLRIWTLLHIFYMYYIDFNYVFHKVSCIIIYIMILCNWTAYIIKMIKFIHTRYLIIYILFILSGGIIEVMDFPPLFYLLDSHAIWHFLSGLAVPFYYLFISKDIVNETVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWB7</accession>
    <name>A0A4V2JWB7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2417p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002417">
        <property type="protein sequence ID" value="TBU07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2417p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29075" checksum="F1BE49152AF0BF40" modified="2019-07-31" version="1">MQGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPKLLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPFKGAKTEEDGAKNFKTKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWB9</accession>
    <name>A0A4V2JWB9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2410p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002410">
        <property type="protein sequence ID" value="TBU07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWB9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2410p0010"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="23078" checksum="3335615611779870" modified="2019-07-31" version="1">MVHNTFEIPLNSLNDFIVSYEFHIPTNLIQKLKEIHFSLQEAIKKNELCLENKENIIKNNDDNGGFLKEEFENNFNKISKEKENLEKNLLQNNINNKNDPMIELRTLLAKMYLVTKSMLGYEITFNENNVILHSSYAFDDEDIFVFEIDDNNSCTLKSNEFVANWKREIDLYLLYGKSVPAFLSAVTLELYNQKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWE5</accession>
    <name>A0A4V2JWE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2367p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002367">
        <property type="protein sequence ID" value="TBU07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2367p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="61" mass="7506" checksum="4E1083EDBF251598" modified="2019-07-31" version="1">MEVRVNTRIKNNIQIRNNRLEMLIFDKKKSNEIERIEVRITSRKTTLFKARHKFWEKFLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC1</accession>
    <name>A0A4V2JXC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1316p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001316">
        <property type="protein sequence ID" value="TBU11222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1316p0020"/>
    <dbReference type="OrthoDB" id="2194045at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="224" mass="25879" checksum="9E9769F0DC19175A" modified="2019-07-31" version="1">MNNFKSTWRIFKYSKEQLSEDLLSYCGNDLSLYSQTISHSQIYNSASKSQKWLHIYSHCDKLLEVSIDSIFIEIKLFINTTTYKKPNNNCNELLSMPISFTADSQPISQTNSQCDLSTTTKIILLEKIAIKNTYLYVTSKDTHIAIKQSNLPKIQLTFFNIQNALSFYSFINSNIGINTYSCEMQQKINQFKQIVGSRDIKIISSKKTIKELMCEFKKIVINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM9</accession>
    <name>A0A4V2JXM9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0759p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000759">
        <property type="protein sequence ID" value="TBU12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0759p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="104871" checksum="30E0F2EC1C09751F" modified="2019-07-31" version="1">MNTNPYSFLRSKFVNNLESVKSIEKLLQVFRLKKYLRKISILSLVYFFNVTSRCVQIKIAFFNEEYSDDLILRFKDHSVCNSSDKSSLHCKSKQRVEGEFPKGFSSSFHNMALKRKCTKQRDLNSIINSSGQNHSKTQSYQSMEPINWFSGPTDGIFSNFGSFNNQKQNETQCLVLENPSNIISTCGTEKRKRILPKKHLTTYLIFDYSSEFLIRCELFDYHLKLGVDYVTISINDVTKNEVNRHLFSLLLISLRFGYDPALSGLKNEHFLDFVSILTDLSVYSESNALNMLYRYLFSFLLHFEPEFYKNFTLNPYNPFVIRYKQILIPFLDVLFDQIEIISDLSKNEVSFHKIDRIKRSNFLYTFEFYKIKIRITPEALNAMKLNSCAQKRDFFKWFLDFYMIKGIRISADDSFYSDCKDPDKASDYLKNINSVLETSIMDSDLFQILVQNHKKTIKLVELERVILSEDNIENIKHFSNLEILIFVSCVIYKYRSFLNNIEIFYPKLRILKLIGFRLSSKFFNVLTFSMLEEIDLSLSNYIGNPRDLLLQEKSNRLMSFKMDGTNFCFKIINFFMKSKFLKRLSIRNADLSYFRNNISFWGCRNSFDFLDLSGSTLGKLFLSFFSQNLKSEVLVLKNLKRRYEALTILNQTWLYLSTKHLRYSEDNISRNFFYFLRYFCYLESLEILDTSITMSEWQHFDLSHMFRLKSVNLSQNRLSDYNFNMLPLGINLDVLNVSECNLNVGLMSFLCFTKKSDSFKKIDISGNQLSMIDLAILIQFKNLTHLKITLANDVMANYFKEYGALCCENLKSLVFVSTSVEVSIFQFVMLQNSLLKLKFKFCTIYDTGLTRENIFTLKFLKKVTFFQTHFHPEVLKILDLFQILKIPLAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP4</accession>
    <name>A0A4V2JXP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0688p0050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000688">
        <property type="protein sequence ID" value="TBU12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0688p0050"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="377" mass="43498" checksum="5A16E8F77F90959A" modified="2019-07-31" version="1">MSSEEGEITTKRNNRFVEKEFGYNLGDVIGEGTFGKVYLGYLNGKSFALKKILYEKRDTNGFPLTTLREIKILKSLKHKNIIEIIEVTVEKKDKEKISKSTTDVYVVFPFMKQDLSVLIKNKKIPIIDIKFITKQIIDGLFYLHSHKIMHRDLKAANILLDDQLAVKIADFGLAIEFSENGKYTPGVVTLWYRSPELLLGSTFYDYSVDMWGLGCIISEMLTGRPIFPGKNEINQLNLIISICGSINKRTVPDIENFRDFFKFKLPQGIRNISKYHEGYDETAINLIDLLLNVNHDTRLTSEKAMNHPFVHREQTSLLKFIDSSSSNKRQKKNEDEDYLSLNNFMNQTTEFSFYNKYEEKTDKSSSDELTFIPDSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT8</accession>
    <name>A0A4V2JXT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0547p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000547">
        <property type="protein sequence ID" value="TBU13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0547p0030"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11936" checksum="2B078A74C0C923B0" modified="2019-07-31" version="1">MIRLEIDKDKSATFHECCEDRDNLIEGVTVYKYLEIIEDRKSNPTLNAFYEIQITDNKNDAVRAVLEKKRIFFAQDLNGVELRCEHMILQHLNSIKTIKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV9</accession>
    <name>A0A4V2JXV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0471p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000471">
        <property type="protein sequence ID" value="TBU13312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0471p0020"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="37506" checksum="6F52CECDF9496C41" modified="2019-07-31" version="1">MNPVGDVNTIAADIGTETLKIGYCGALHPTIFNSTRQNPNYESPVLHSVISSPSYYLSLLTSSLSCNDPLVLAVNYEEKMVVKKNIVGYLLDKKYTNGILLVPSNLMDMYSHGKSSGIVVNMSGGSTSVSTIIEGNVTHYYSVPIGGFDLTQKFRKYLNEEDLVVRGYKSNEKGDNDAKFAFLKDELCREIKESVIEVKSERNSETFYELPSGKSIKFGNERYELADYLLEKSNLIETVRSLIDKNDQDVRHILVNNIMLCGMGVINGISERLVSELSKTYSPSKIRIYWEKKVFSTFFGASVVGSVGMAKNMFITQADYEECGESILERKNVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD8</accession>
    <name>A0A4V2JYD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0035p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="794" mass="94370" checksum="3D352B198EFFBD45" modified="2019-07-31" version="1">MLVSVFFTVNTKTYFFRKNQHIVTLLMRLLCAMSSATVSFLVINDENCIQNLFATDLTLEMIFTENKSVEWINEEEKITIFKNNILRYEAPSKQPKYYNPNIHTLHHWNNMVFNSKLIKKHLDSKSTNIKIFLKDISYPALLLFLKLIDNSDSFIFQINIQDFLDILLIITILDIEKTKERDYFLKDLLRNVMSEMLRQDFTLYFDNNLCRYHYSYIKKSLFMDIWIFFINFITFDDKSAQIFIVLSGNRNLCFKRTYMFSDSYNSIKKIKKNQLYLRFDDISIRKIYKIRNQKHYMNTWIFLLKIVDLDLLYLVFSTEEIYKKATVLFSSVTFNAEKLYIVTAKNSIKLFLNKQIPVISNKLKVLKLESSLTSEDFKKLFGFCGDITKLTLKLESLDFQGLKIIKKFCLMNLNKTCNIFCKIYELLNTDFKIIKNIPNNLKIYASKLQTRSVDIELSTVSTFFPSIFSYKYIYLKNLSLYNFFLLLECFKFKSVSFDFTKNSSPYKLEDSVYRYLRYIQTMKYMFLANIYIRDTLLEYVLDSNTIVSLEVLNSVCSYNLKFLSTNPMTNEKLKTIAINTISSGIDSSFLIYLNKFKAIEIFILLNTEISFTTSLEENNHYNFIVEEESKIHLKYLEVKTKPDSMESSNYLNFLSKIYNFSSLLSIVYCVFSISEIEYQYFLKMKQLESMRLKIRNRTECIDFGNVFNYESFNTIILLSIDVCLIRIKDIEIFKKFKNLGYFSIYCDNFDNGSIFYIKKKDFKRTVLVIERPNRASRSKEINNYLDSEFTFKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVE6</accession>
    <name>A0A4V6MVE6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0101p0040</name>
        <name evidence="7" type="ORF">CWI38_1151p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="PITJ01000101">
        <property type="protein sequence ID" value="TBU04682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001151">
        <property type="protein sequence ID" value="TBU11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVE6"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0101p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1151p0020"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU04682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="164" mass="18134" checksum="C4C9EFA3C06566B5" modified="2019-07-31" version="1">MVKVFFDVSCNEKQLGRIVINLRDDVVPKTVENFRCLCTGEKGMTYKDSTFHRIIPDFMIQGGDFTNHDGTGGASIYGRKFNDENFQLKHTKPGMLSMANAGPHTNGSQFFITTAKTPWLDGKHVVFGEVESGMDVVKVIEKYGSQSGKVKEGCKISISDCGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTW3</accession>
    <name>A0A4Q9KTW3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_2139p0010</name>
        <name evidence="6" type="ORF">CWI38_0076p0040</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002139">
        <property type="protein sequence ID" value="TBT97670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTW3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KTW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2139p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0040"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT97670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11381" checksum="26E8FA4FB438D91D" modified="2019-07-31" version="1">MEYIAAYAILSVAGKPVTEDSISKLFTVVPGKECDKEQVQLLINNIKGRDYNSIKEEGSKKMSSFSSVSVQPSAVKVADESEKKEEAEAPKEEEMDLDLFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUC6</accession>
    <name>A0A4Q9KUC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CBF/NF-Y-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_2039p0020</name>
        <name evidence="5" type="ORF">CWI38_0644p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002039">
        <property type="protein sequence ID" value="TBT97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000644">
        <property type="protein sequence ID" value="TBU12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUC6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KUC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2039p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0644p0020"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="153" mass="17320" checksum="829F84827A3B3884" modified="2019-07-31" version="1">MPSSPTSKREEAILPKGTVNKIIQDTLPKSVSIHKSTKEFIMTCCLEFAHLITAQAAEMCEKESKKTITHEHIFQSLQCLGYSEYVGECTVAHEEYVSHCKMKPSKINKLKTSGLTMEELRKQQLALFESARNEVYRMDCEQNGTSDNNEGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L654</accession>
    <name>A0A4Q9L654_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0096p0010</name>
        <name evidence="1" type="ORF">CWI37_0358p0010</name>
        <name evidence="3" type="ORF">CWI38_0023p0120</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000358">
        <property type="protein sequence ID" value="TBU03093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000096">
        <property type="protein sequence ID" value="TBU04715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L654"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0096p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0358p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="128" mass="15781" checksum="FB2B9B6A6F162018" modified="2019-07-31" version="1">MINRKEENYRKEIRKINNYSNNDQITEYYADEYNAVPYPIIIENNDSEYEVFFDSLDDVLKTYKSMVKKTVMFEYKYANCNRKLFEELYPLLEEAKRILYIYYKRYLIHKIDISSDMYIEEFIASFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7T6</accession>
    <name>A0A4Q9L7T6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0239p0010</name>
        <name evidence="2" type="ORF">CWI38_0467p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000239">
        <property type="protein sequence ID" value="TBU03753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000467">
        <property type="protein sequence ID" value="TBU13327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7T6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0239p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0467p0030"/>
    <dbReference type="OrthoDB" id="2196255at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29268" checksum="BBB2EFE34D4EF534" modified="2019-07-31" version="1">MPSITFSEDEKILLLKYCRMQIIKICRQFSLPYTVHSTSSHFIRNIFYRSDISEYSIDNLITAAIFLGCKSEDINIELSLLLKNNVGLNESLIFQYELLLAQYSDYRFSVSCPYLRMLGCIILLQEKDRVVVKRGQIDINNVSIINTEIKNIENNSFDYEDVLKNIFFIEDINIFWRKSVINLDKIIIMSGFEKITATELALSSLDLPVKYLHSLLEKTDTKRIEEIRNSYLQLNIPDSNVISLLKNKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD87</accession>
    <name>A0A4Q9LD87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2690p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002690">
        <property type="protein sequence ID" value="TBU05868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2690p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30018" checksum="3A6153237479ADA2" modified="2019-07-31" version="1">MLKDKKILLILISLVIFLFMTQKYNCTLIYLLDTLQKYTNDFLFNEMSIFIMTFIFILLPCFSNAIILSALGLFTHEFIRSLKKCNFYCCLYVFMMYLLVLDINSVFFIFLKKYDISLGRNILSNNMYVNGDIYYSNLLVLVSLLLGLIFLQILIYCIEIYEIKCLTGYESYKDLFLELKIVINYFVLAGINILINVFIISYIIIDIWKDIEYKFIVVVSPFVISILSAGIGCVMYKRSTQVDIASSVYPREIKVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LET7</accession>
    <name>A0A4Q9LET7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2561p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002561">
        <property type="protein sequence ID" value="TBU06519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LET7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2561p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="50" mass="5594" checksum="170A5DDB027F7E02" modified="2019-07-31" version="1">MGGYKQFENKGGILEITRDTNDMGGIMDDTYNNTRAVAPISSSNLKFKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGV2</accession>
    <name>A0A4Q9LGV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2475p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002475">
        <property type="protein sequence ID" value="TBU06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2475p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020462907" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="7787" checksum="9BEDB9A7F9FA3211" modified="2019-07-31" version="1" fragment="single">MMSSFVFYILSCTVLCTSDSNINTGTDSNDMCKLKKFISLYDKSVYQSFADIHTVPKLAVIEKIGYVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKA6</accession>
    <name>A0A4Q9LKA6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2237p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002237">
        <property type="protein sequence ID" value="TBU08624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2237p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="68"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="30234" checksum="7B161291475A0696" modified="2019-07-31" version="1">MANNSEDTNKVRNRNLKYIAAVLICLLLASTLLLIGVKLFKEKNKNENTKNTSQENILSDEKVCSKMQEDFVTYLQGQKKINILKFRFDTGLSYAGMGLGDEAVTHLAIVNAANPELLPGMGGLNKGITLWVREREGLSKNGSSEVWNNLTACAEGQTESTKKLGLAAYSRFNGGILLHVIGPQGSLVGNPQQCKNLSEVTELLTNAYKNCLRMANDYECSHIIFSVISGDLFCQSNSKVGFKKSEFLCAIQNAVKKFIEKTEFKNIKVYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKX3</accession>
    <name>A0A4Q9LKX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2204p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002204">
        <property type="protein sequence ID" value="TBU08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2204p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="9635" checksum="A9747650A9ED796F" modified="2019-07-31" version="1" fragment="single">MALDRKKAMIIASGLVISMLFIFAIICGLGYNKAGNVIKSFEADFKKVSATAQFKFITNDLNKTKLGDFASIKGKKVFELPFSSYDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPT3</accession>
    <name>A0A4Q9LPT3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1819p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001819">
        <property type="protein sequence ID" value="TBU10364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1819p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="25505" checksum="1E1A2F9A91D65253" modified="2019-07-31" version="1">MNKKSVILSCVLVFLIIFVVFMITSLVKANSLIDEFNKDFKNKIESSTNTDLKDSLSLFKCCCFEKRDKALEFLDLDDNKDKSNEILQLVTKNEIENLYKSVLEIASISVEVSQTKLDEYLNKFNIFVGTGLFLKRKNKLKLVFEIAKIVQNSVEKINKKTINALLISIHGTDIAKIHDLTVKDKIAKPEKTTEIKIQTSEEDSLFTSQNVIFYVCQFLLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPX4</accession>
    <name>A0A4Q9LPX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1716p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001716">
        <property type="protein sequence ID" value="TBU10499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1716p0010"/>
    <dbReference type="OrthoDB" id="10027416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020631227" evidence="1">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="26481" checksum="12FF9BE1F087D72A" modified="2019-07-31" version="1" fragment="single">MIYNIFLLLMTVLTTEIQMFNLIKTKISDIKVKNTDKNNWISIFTYKNISYHYRNADNHIFRYPKDFFVRLYGFERLENIFIKEYNTNQVLYVLNRLKDFDYMNRMINTKEFLVYIDILLLFEVELGRNIKGLIFSQITNLKFINYDFASNYKKFNYNSNVQNLFLIILKQFLKYNLLTKQDIHEFFGKSDIKKNAKKIFEIKKKFRDEIRFVLTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC3</accession>
    <name>A0A4Q9LQC3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1615p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001615">
        <property type="protein sequence ID" value="TBU10679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1615p0030"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000127">
        <property type="entry name" value="Vesicular-fusion protein SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="229"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="509"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="683" mass="77667" checksum="B2512EB85BE68F4B" modified="2019-07-31" version="1">MNYRITQLTNISMGKINQVYLPPSSKLEITNISTEYFLIIDKNKIFAFNFNDEIPRGCIALNKIQREYLNKSLHSDSVNVDIIRKSALSPISLLRLSVEIINKDNREIERNKFVEIFKNMYLNFPFNKNQCFYFYEEYYGYKVTVSEILTVGEKDYGVLLGGTNVYVVSSGDRLTFIGNCGDNLLLKPDFNFESLGIGGLKKEFGIMFRRAFVQRVFTPEIIQRLGIQHVKGIMLYGPPGTGKTLIARQIGSLLNARPPKIVNGPEILNKYVGQSEENIRNLFLDAEEEYKKKKEKSSLHIIIFDEIDAICKSRGTSGSSGIGDQVVNQLLSKMDGVESLDNVLIIGMTNRLDLIDKALLRPGRFEIHIEISLPDEESRYEIFKIHTKQMEKSDFLETDVNLHELAKVTRNYTGAEITALVKSAVSYALERKVHEEKKDENIKIVGENNIKVTMTDFMMALEEVKPAFGVNEEEFSSFKKVYYELPSFTAATEIGSSFLTKVKTTNLYNTSSLLYFGSPGSGKTTIAVRVALNSGFPFIKVISPKDMVGLNEYEKVNFIKDKFYDAYKSEYSIILLDDIEGLIDFVGIGPRFSNSILQAIKIFIKTEAKNRLFVFGTASSIEVVRECGIYDCFYGHCEIKDVDFDDFERLSLQNKDFSKIRFEGNCPIKKLLSLLEFPDISNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH4</accession>
    <name>A0A4Q9LQH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1596p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001596">
        <property type="protein sequence ID" value="TBU10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1596p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020564321" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8519" checksum="70BD75422B917C5A" modified="2019-07-31" version="1">MILFSLSFLLALYSCAENLISNGEMQNVRNPSLHNSREPKSGDLSDNLFNKISNVVAEFEKYKSTFLTENTQKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL2</accession>
    <name>A0A4Q9LQL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1149p0040</name>
        <name evidence="4" type="ORF">CWI38_1444p0020</name>
        <name evidence="3" type="ORF">CWI38_1717p0020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001149">
        <property type="protein sequence ID" value="TBT99990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001717">
        <property type="protein sequence ID" value="TBU10497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001444">
        <property type="protein sequence ID" value="TBU10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1149p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1444p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1717p0020"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052276">
        <property type="entry name" value="Diphthamide-biosynth_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240:SF10">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="236" mass="28534" checksum="BDBD0431842F80D4" modified="2019-07-31" version="1">MVEENLYKILNLKQFSSSKEIRKAFIKKALESHPHRTGFNSEEVFIRIKNAYDKLSDSTFKLNYDKTLLQESKKYESNEKYKNSNITRNNSNDEMIFETKKEYFNINNENINGVFRDKNVDKYKEEYDDFNIKINGKNCKEKKFKSNINLENLVKIYCKSGDLNLLKFKCKRFGKIKRFIVKESFVFIEFRNLDSLKLFMETEKNNFLIRRLFYFDEELYKTESELFDKLKNLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL3</accession>
    <name>A0A4Q9LQL3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1523p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001523">
        <property type="protein sequence ID" value="TBU10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1523p0030"/>
    <dbReference type="OrthoDB" id="2195775at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28694" checksum="D232534C610C463D" modified="2019-07-31" version="1">MFQIFLILTTYIFTRNIVDSFLGKKLNIFFSGMENYFLAENLTDFSNKPFIIQNRLVEDENLVITNKCELLKNGLEYEIKIGDSKLCSDKENVRKCDAKEVQPWKIQKMTFGFSVSRNDNCITRDKTGKIKLSKCDTSKNQILFILKLDDSDKCLEMTGNLNEKPKNVQELAYRRKLAPLIEKGVLKPTETSNTSKNPADLKKLLDKKFPDKTKNQKSKKVYASLWNNTWGFKIPSLSIGDWTKLFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC7</accession>
    <name>A0A4Q9LRC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1636p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001636">
        <property type="protein sequence ID" value="TBU10636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1636p0030"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="299" mass="35779" checksum="F4F42F6E3FFBF498" modified="2019-07-31" version="1">MQKYRLILSASESTKRYLITLPVPVTDLSSPFTLDRDRSVKDVEEQPRNTKKKSEQLEYEEEAYIKLKEQEKYPLVIEDAENRAFSGRLQDMPNDNYFIFINTGQNFQVVPLRRWYRFTQKISYETLSLEEAELKLSKKNREEDRWMMHKKKDGEKDLYDEIDYTEEFDDDDGEELLVSVKQRPKKLSDAGKEMKKLMQNYEKEEEEEEPVEEDIKESIKEHNKFKEEPKRVKIPDLGENNLKQIFIGKSLSIKELLKIVKERFRIDENAKNVIKNFIKENCVFKIDNKTNEKLLELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF1</accession>
    <name>A0A4Q9LRF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1939p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001939">
        <property type="protein sequence ID" value="TBU10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1939p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="5987" checksum="1FBEAD06743BB616" modified="2019-07-31" version="1">MEDGVKHFQTKNSIITILNAETRLKNPTININKKLNLEEEMMVVKKFKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG2</accession>
    <name>A0A4Q9LRG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1375p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001375">
        <property type="protein sequence ID" value="TBU11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1375p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="27756" checksum="77168F07BFE48619" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNIKIKAANDADEAKKSDSGKQKCEIHPLAISLPSSPYTTITPPPPSQTCSKMQNSGLASLPSPNTPLHSSVEVSACEPSYYMTNPCALAIPEGNRLMALQTIFDSVTADSKEWPQIVFFAVQTRFERMPKNGWTELHGYYNEKFGCTETLEMLKKLAQIEMGKELKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISEKEIRKLPSKLVDSKVLDVINRVVGEYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ5</accession>
    <name>A0A4Q9LRJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1422p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001422">
        <property type="protein sequence ID" value="TBU11034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1422p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="644" mass="73328" checksum="9CCBD8D5D2E5229A" modified="2019-07-31" version="1" fragment="single">TPRSHTSQISSTETPSESDIETTGFLTPRSHTSQISSTETPSESDIETTGFLTPRSHTSQISSTETPSESDIETTGFLTPRSHTSQISSSKSKNPSSLVNRNFRNPRLFKTKHRNKIRSESRISRCKSIHFSTNTPINSTLNHGSFVTSEDTINTPFDLNNAINFTSAFENFLDGKAISTEKTRIIEDEIEGGNKVENEGDSADIEDEDTLCESVEYLTCNDLSHDDSSDFSIYLSSLSSSENPSVKNIRNEQHNKGLESTIESTSDSIFEITSESKEKKESYVTEEMKEKRKQRKDRKALREIEEDIKIFKELLSGDEFSDREEFVSISSENLNPFVRNYEVLKQRAERKNRILKNPKPIPLPGESTESECEISCESNSEFLSCTSGSERSKKVEKGKNIVEVVLTSPDDIKKTDNYLVRAFKKIKEKYINFCYLPAFFLKKGMCFFKDTPYDSGESTNEASEINSEFDEVNSDSSEAKIVSRRDVLNFLNRNCEDKDLRKILEKEEYFIKIKNIFKKEILRNKKISNEFFLSKLEHVFKDINNFIVNDQFYSVQETVCSSSEVTSEYESCISQFKDRIESEEISSFFCSLSTNSTNYDLKPNDNSNNEVEPVKKDNVGIYLKVSAFCTFILSLIGSGLYFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM2</accession>
    <name>A0A4Q9LRM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin elongating factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_2000p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002000">
        <property type="protein sequence ID" value="TBU10130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2000p0010"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="11">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="11">
        <location>
            <begin position="422"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="753"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="540"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121536" checksum="F114FB8AC892BF78" modified="2019-07-31" version="1" fragment="single">MCINTRNRNKIQFDIFSNCSDGFCYNLSGILNMYCYKIVECNMYENIKREVIYNNTMIQGFDDSGVDVNGDRLGSDNIESNIVGSDDIESNIESNITDNISNISNNNITNNNISNITNIESNITNINNNNTINTLSSYGFTTSIFFLKLHFSILTYTKLFEDHSTLSQEYEYIEDIEIKKNIETRIMTLRMLFNTEIFKYESVFIDFLMEYMYRCGDVGVRGIDSGGGLGGNVVGGNKGSDNVVGGNKGSDKGSDNNISNIGNNNLSNNISNIGNNNLSNTNQHSNQHTNTITSVIGYMIDCKTYLIMYCNSTVNSKWIRFINDILNDRVCISSSGGVGVGVDGVGNISNSNISNSSISNSSISNSNNNPSTTNISNNPSTNNPSNNNTSTTNPSTNTPTNTNTNTNTNTPTTTPTPKISLHLKVKCVKMLYYYKEDKKKLFKNKELNISLINLYNSINRMEQTFYDKYSVRYYISRILREEEYYDVGVRFVSYMIGDLEHLLCEGFNAIISIKRSEGNSSVVGNSGGGVVGDVDGGSRGSSNISNNRGSSNIRGSSNNNNIPSSSNNPSSSNNPSTTNNINTNNNISNNPSSTNNINTNINNNPPNTRDTFVARSCFVYALECLYFILFLIRRNKRVFSKEEVLNRFVININSNLKTIVGPKCSTLKVKNAEKYNFKPKEMLRILSLIYIEMDTLNFIESIVSDRMYFNMSLINRCYFICNEKYILSEIELEKMKKNIEKMEKCVVVEDEDVPEDIMDPLTCSAICLPVKLVTSGVTVDRSTFELLLLDGVDPFNRERLDESKGVVDEEMLRRIEESSKGDEEMDSKDKDIIGGDVLIEEYNKGCRESKDKEIITGVKESMYKELKRSIYNGLYLCRSMYKELKRSIYNDCTYVGSMYKELKRSIYNGLYLCRSMYKELKRSIYNDCTYVGITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP3</accession>
    <name>A0A4Q9LRP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1845p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001845">
        <property type="protein sequence ID" value="TBU10331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1845p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="12493" checksum="1C0DAA0F7A769F18" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNASVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS0</accession>
    <name>A0A4Q9LRS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1813p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001813">
        <property type="protein sequence ID" value="TBU10371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1813p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1647" mass="187367" checksum="0D245F2552B9666C" modified="2019-07-31" version="1" fragment="single">NTPLDIDSNKNNTPLDIDSNKNNTPLDIDSNKNNTPLDVDSNDNTPLSNSTSNTVNNTPLINYSSNHIYNTPLTTHHIDNTPLLLTLPLYDVPFPHILDLLSNNTSYINTPLWFNNTLIEEEIKGYSFPYKVKGFNYNNIGNIPLLTVELYKILYYILIGVNDIEKLDILINNRGSDNDMLDSDMLDSGLEGVSNKNMIEGVSNNIDDYHPFSNSTSKQQGVNKSIDSYHIFSNSNSKQQGVNETNDSYHPFSNSTSKQQGVNKSIDSYHIFSNSNSKQQGVNETNDSYHPFSNSTSKQQGVNETNDSYHPFSNSTSKQQGVNNTIDCYHPFSNSTSKQQGVNDSTIDYHPFNNNLYTHNPVNELTLFKRNVIFLSNSVLSVCKGYSVIELKINFIKKFIGCSVKEYKKLKGIYNKLKGVENFKMYKCSSVDIIGGDIGRDILGGVNNSTNEQQGVNNSTNTQHHFNKNTNTQHPFNNTPYTQHPFNNTPYTQHPFNNTPYTQHPFNNSTNTYHPFNHTPTLLHTTNTIPSCLTFIINIILTYNIDPLNIIRNNLINNYNDMINKYKNILYNEFIKGYKYGESNEYTFYCKEFIVIYKEYIKRIEDIENKIESRNIKGVIEEYKRVRGVSDKDKYRGVSDKDKYRGVSDKYKYRGVSAGTYNYNPVNNLSNKQQGVTDSTNNYNPVYLNTSKQQGVSNSTMNYNPVNNFNIIDFSDWLDSYYTGLFNDIVLLGMLFKKEVLIEVNDIHRLLDYCYISSKVKGVSDKDKCLNVTTDVQQGVNNCTNEQHPLDISTNKQHPFNNTNIDIKSLIDTLIFNTPYSYTTSVISKAIYLLYYNRGVNIEEIVLECIKGDKYIEVCDKGCNRYSKGRCVDNTPLNNSNIYNTNTGTTGTENNTSISNNNTPLSNSNIYNNNTGTTGTENNTSISNSNTPLNNSTIIPYICCSSLTDMYFTYIDSLMLFVYKNINNKALLLDRCYGDSVSDCSVNISEIEIRNIIRNKGGVNYKDMLEGVNYKDILEGVNTSTYKQDPLNKSSDKQDPFNNITDKQHPVNDTPYNYHPLNNSTTQHPHNNTLPFFNLLSLCLDLNVKRKYKEFVWLVYKKYSIQELEGWLIRGSIGDFIDRLLFIEELVINCKGNSVIYNISLQYLSFNVVEEVIRRIKKGEKGIEVLKGVIYNGMVKGYRDSKLEGVSYMDSKLEGVSYMDSKSEGVSYMDSKSEGVSNKDSNYKAFSNKDSNYKGFNNSIDIEEGVNNTPYIQHPVSNSSNNYHPFNNNTYEQDPVYNSIDIEEGVNNSTDNYHPVNNTSYNYHPVNDSTILNSTLNTPIISILKIVDNLYTFYDKPVISMLKRNKSKNKITCVCKEDVIINKWVKDLLNTLSINKGVCDCFRWKGVIKEMSCNSKKIKEVLLEELKGYRIEGVNNSIDNYKGVNNSIDNYHPVNNSIDYYKGVNNSIDYYKGFNNSIDNYHPVNNSTNTLHPVNNSTNTLHPVDNSTDNYHPVNNTSYNYHPVNNSTNNYHPLNIPFIFYNRNIPLNPYSKEERVLGSIITYYTEIEGVSNKDIIEGVSNSIDVYNPVSYNTNTLHPVNNNSNEQQGVSNNTNTLHPVNNKSNEQQGVSNNTNTLHPVSNSTNTLHPVNNKSNEQQGVSNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS5</accession>
    <name>A0A4Q9LRS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1915p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001915">
        <property type="protein sequence ID" value="TBU10245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1915p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="45064" checksum="BE754017B5C50ACA" modified="2019-07-31" version="1" fragment="single">MRDFPQPKKDNITEKQNINSAGDTHIFVTNNLQNVIDNISISIPLVKKFFESFLTKMESMVDESLNVAIQKAVKTEFYYRLQNITESSKFIESSEQQKYKGIWADKQYFMGSDATNRLKAIGEWRNYFRVTDFTSEVLKDIRSSSNDPNFYKFLVEHASTLSICDSKKNLTFLREIVQHNTFIRSVEDICSKYKCSLTAYYNQPSVCKNTEHFKMITNFKGDFNKKSLYVICDTAEYHGIDVVNNNPNYIFPDKISPTNNRFLKDSFKQCGKGAIYLSFDLRIENLMFIFGKKLLDVVGKNNFIEIINTDLPTENAKRKTLTNNKFCYEIKRFLLFFKSHIKSETYILFYMYRVQDNDWTNISKELISKHLTNKLSSKNIEPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS9</accession>
    <name>A0A4Q9LRS9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_1551p0030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="PITK01001551">
        <property type="protein sequence ID" value="TBU10786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1551p0030"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU10786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="420" mass="47244" checksum="1FEB315C13EAF0AD" modified="2019-07-31" version="1">MKNRIVYFYDPSIGNFNYSPGHPMKPHRVRMTHSLLVNYGLTNYMDTVRPSQASFNNLTNFHSADYINFLQSVSKSNMTEMFSDLQKFNVGDDCPVFDGLYDYCRITTGGSLCGAYKLNTGQYDIAINWSGGLHHAKRNEASGFCYVNDIVIAILELLKYNERVLYIDIDVHHGDGVEEAFYTSDRVMTVSFHKYGEYFPGTGSLSDVGILKGKNYAVNVPLKDGINDESYSSIFKPVISKVMEHFRPTAIVMQCGADSLAGDRLGCFNLSHFGHSSCINFVKSFNVPLLVLGGGGYTIKNVSKAWAYDTSVILGVEIPQKLPFTEYIEHYGPDYNIDVPVCNMANDNTQEYLDSILKSITENLRTIESVPSVQMVEIPPNFVEDESDEEILWQRFKEEAGYANTNEEDLDADDVRLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS22</accession>
    <name>A0A4Q9LS22_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1269p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001269">
        <property type="protein sequence ID" value="TBU11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS22"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1269p0040"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10853" checksum="CF1D17C6C96D2D63" modified="2019-07-31" version="1">MKNLTQLISEVENILLCPICLNILEKPLKPKCVHYFCEKCIKMAHRLKKECPVCKEKITGNILYSCPNMNKILQIYKILVQETNEESEFPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS83</accession>
    <name>A0A4Q9LS83_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1785p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001785">
        <property type="protein sequence ID" value="TBU10405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LS83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1785p0010"/>
    <dbReference type="OrthoDB" id="2195721at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="322"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1461" mass="165055" checksum="6959A0D40C782083" modified="2019-07-31" version="1" fragment="single">MTEADSPTLKNIKSTDWKIRLQTYQSLQPHEISPEIIKTLTKETTVPVLEAGVSILLIYKPSYLYPHIVPLFCNLCTSKVSLKSKILEIFFYILNNLSKEVLFDLFIFLENKNPKLVCSVIVLIKDVTKQYGVIYNVEGINLSNLLQHSDSSVRKEAMVLIIEIYKTYKERVLIYIKGVKPIILKNLEEEFLKIREMSKIEGVKDKGSKLEGVSDKGCKLEGVSDCASKQQGVNNSIHEQQGVSNSIYKQQGVSNSIHKQHPVNNSADTYHPISDSTDIQYPVNNGTDTYHPFNNSTDTYHPLNNNIPQQHPVTETPNKQHPFNNTPIKQHPVKLDEGCYDMVKSMDWKERKMGVEEIYKYLKSGGVNEGKVVGVLSKMVSDINIQVLLTVLDTLLLLEKRDFQSRKDFFLNLCDRFKDKKNNLSHKINLVLERAEAEESEIIEILDTKNCNVKSGVLEYIIGLSRRRKDMFSSECLRYIYECTFDASEDVRNKAFKCIGSVMVFNEEKVNEFLVNKDKSKITRIREVFKVEGSKVGVSTKNMIEDIKGVNDNNMIEDIKGVSNKGSSIKDIKGVKDSSNINDIKGFSNKGSSIKDIKGVKDTSNINDIKGFSNKGSSIKDIKGVKDSNGNKGGFSNKGSSIKDIKGVNDISKDKGKIIRSKEVLVPIDIIPVNNTPLNISTNTNTPLTNNHHTNTPLTNNHHTNTPLINAINNTPLSTNHITPPLNTTLKRRLSSSTNKILKKSISNRKVKNGQEIEEYFTEEFISKLKSVNTKEEIENILSLFDTLDKTLVSDFIILFLINNDLLNYIKPLLLYFIEKCYILQQEEVRVLIKYILFKKEYILLKMLDKVFPISKLFLEYERVVDIDRVGVSNEVGRLVSLHGIFKGDVSKYEGGVSKEVDRLMSSKGYIKDIKSMDSRLEGVSKEIDDYKGVSKEIDDYKGVINNTYDYKGVSNTIEDYKGVSNGIDIQQGVSNSNDIQHSFNINTYEQHPFNNNSSNQKGVIYGMSPLNKRTREYNVISDNIKKVEGFKIDKNIEINNRENDCYSSSSDSKVIDKSFSLLNIKSDNYKDSKLEGDNYKDSKLEGDNYKDSKLEGDNYKDSKLEGDNYKDSSYKDSKLEGFSIRNSKLEGDNKDSNYKDLKGDNYKDSNYKDSKLEGFSIRNSRLEGVSDKDSNMYINTPYNPTSTNTPSYPHTPYNPTSTTPIDNTPYTPSTYTNTPSYPHSPYTPTASTTPFKYTVLDKFRKEFEEGLKSQPFTSRSDLQNILTRLIDSNTESSINAFKSLNTIIDNNISCLLFSCNSIVSSILIQLNEFRRNKKKENNKEYCIYILQTLFKLTKNSFFSSYLSLDTLKSIHLDLIGYISEGCTVIVDILINLCLLCECDVILRVYLSMLSGSSSIKGVSDRGSIKGVNYIGSSIKGDNYIGSSIKGDNYIGSSIKGDNYIGSSIKGDNYIGSSIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC8</accession>
    <name>A0A4Q9LSC8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0111p0080</name>
        <name evidence="10" type="ORF">CWI38_1429p0030</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="PITK01001429">
        <property type="protein sequence ID" value="TBU11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1429p0030"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="146"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="164"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="31779" checksum="347D5E92A58DADE7" modified="2019-07-31" version="1">MQFKRKIPLNSESSVKGNNGITLVIGGCGLYTGAPYFVSLSSLLSGSDLSYIFCEKETLIPLKVLLPEAIIVEIDFHEWILNRVSVCVFGSGLGRPTKEICEKICRILEYLMKRNIFIIIDGDGIFFYSNNFEFFQKYKNIVLTPNYNEVKYLKDNNIHYVLKKGFVDVIEYNDRKIEILNRSHEIDDINQNVLASTEMTLFKPIFVKRCGGQGDILAGILATFLSWTKTAEPDDVTDSIKTASIITRKASEFASKKYGMALKTREIISEIQKSMESVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL6</accession>
    <name>A0A4Q9LSL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1132p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001132">
        <property type="protein sequence ID" value="TBU11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1132p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="19720" checksum="FE274AA1EB77613D" modified="2019-07-31" version="1">MVLLGKVCCLKLESSVLHLHVIYVEGDGLEGGVSVVVIYKSDSYMSIVYKRGVSVVDVRVIYKSYSYMSIIYKRGVSVVDRGVSVVIGGRVIYIRGVLFIRLIYKRGVSVVVGDLLQIVETEKLRNYDLLVNELGLIYKCNLGLIYKCNVEIIPYVITWDGIVTKYYNMYLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST2</accession>
    <name>A0A4Q9LST2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1101p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001101">
        <property type="protein sequence ID" value="TBU11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1101p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12602" checksum="8F7537E08050AFE9" modified="2019-07-31" version="1">MLRQNSVKGIKNKLETLYFARPRRLEPELNVAGFKLSVIGVFERAGCINNHTPFKAQRHPLESKTSLRIPNEKLSQYLQICCLFKKIKHFFLKKLENMISINSNIVVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY9</accession>
    <name>A0A4Q9LSY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1071p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001071">
        <property type="protein sequence ID" value="TBU11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1071p0020"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF179">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="29212" checksum="9BFE1CEA44348262" modified="2019-07-31" version="1">MHSLENRINSYKAWMQSEECTPNTLSMSGLYAEKGHLTTKCFFCSLTLKEWSSSDIPTKVHFNFSPKCCIFNLSKIQSRKKTFIKEIWPHSLDLAEKLSSQNFFLFIIKNEIPDEIFCYKCGYNTCELKNTENLVHALEHKKVCPVKSKQQLFTLKNNSPLFYVNLFQGKYISAFISFIESEIFIPNEHKEKYKRLLQYGQCYNIFDNVDTCLESALHCLVQSYEERLDKLIEEQIKSLQNFIGVSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT36</accession>
    <name>A0A4Q9LT36_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI37_0828p0020</name>
        <name evidence="19" type="ORF">CWI38_0500p0040</name>
        <name evidence="18" type="ORF">CWI38_1107p0030</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FI-OER-3-3</strain>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="PITJ01000828">
        <property type="protein sequence ID" value="TBU01026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001107">
        <property type="protein sequence ID" value="TBU11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT36"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0828p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1107p0030"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="14"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU01026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="271" mass="31700" checksum="4CED8458B31E54D1" modified="2019-07-31" version="1">MKLLRKTFWTLDDFELGKPLGRGRFGQVWLVREKRSKIIVALKMITKSQVTGSDNIKQLRRELEIHSNLKHENIIRMYGYFYDSERVYLIMEYAGGGELFDILRAKGKFSECESSKYIYQVARALQSMHFNSVIHRDIKPENILVGCDDKLKISDFGWSVTNRDHNRYTYCGTYEYIPPEMHRNKKHSSFVDLWCLGILCFEFLVGQTPFHTSNGNHAESSRKAVNLDYTIPSFISSSASDFIKKLLVSEPNSRMRIEDVFNHPWIKKYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT75</accession>
    <name>A0A4Q9LT75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1465p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001465">
        <property type="protein sequence ID" value="TBU10941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1465p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="25111" checksum="009FCA5038405957" modified="2019-07-31" version="1">MDKSDNFSFCKEKTLIINSILLIDSEINIFEIIKAHLSNFEMEVLENILFTSEFKFESVKNKIGLETINFEDSERFIFGFVSNFFDLKNMKKFFINTLQFPTQNEFKFLLNQLTASNITKSILNIEFLLHFGYFIDDWINLKILEIIVREKSEEDISFNNLSYTNYNLKILRIKTATRRSFTSSIIDFIRTFHMVRSIDLINFSIPDCQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTB7</accession>
    <name>A0A4Q9LTB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1023p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001023">
        <property type="protein sequence ID" value="TBU11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1023p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="352" mass="41959" checksum="E30A99054DED4BF6" modified="2019-07-31" version="1">MENKDIIVDRNMNCDIFKNTFNEKIINISSGSFDEPKGCYKTAISTRSMKNTELFRFLGELEPEDMSNSYVLILSLKIKNKECNYIVNIIEKIDKIVAIMNKDPKTNKNKLECELKTEMLYLKTIYHDFSYINNLSVSEKIEYIAKNFTIENENLASTDTIYLLVNKKMDLSERCGLCHLLNQYFESFGKQNRYLYILMENITQKKPKKIVDFISEKKDDIHISFFIFNFKNLVYDLNTKSNVKKPTFSYNKKFHSILMCSYWEDKKPKTRFLYIGFEILLNNMTRPKKIYEIEIKENNTSHISKENPIIFKHRVNLVFFYDYLVECSYISYDEKNPAIRIKMLDFLSLKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF7</accession>
    <name>A0A4Q9LTF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1131p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001131">
        <property type="protein sequence ID" value="TBU11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1131p0020"/>
    <dbReference type="OrthoDB" id="2193084at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="610" mass="72201" checksum="747846E8CF3EF984" modified="2019-07-31" version="1">MTNKDSIRELLIAVEDLKSIYPLQKEINLMNPKYNQEEMKIFVSGVLEVVSELEKENFTFSYLHNIFKLLCENLMNLKGIFSEYLKVVNFYYKFCVSDSQKMFELYKNLIFATLEITKNTFLPKGYPKLCVEDANSLIILYISMAEYFYKLECFADSFYLLQRASELFSVVGSLPPKEFTVKYFILLFNIFMKSDCFFNALNALHKLCSFTGEIYVSSLKFDTFYSEFIDLVEITRKKNEGNVFGSLFYNLQPVDLQNIVKVVEESMAVKVEDGIYCDFSFEKEKWKFIFENLGKNIQLNEENLEILSFCRFKNVIHKKEKNLLFLEKIGDFKSVSKIIYSVIEELKGKKIKKTIEIEESVKEKITNQEISDHKEEELEGLDMEIKLLENKIKEEIILQKENIPQEKTEKNVKNQKIRTKKKPIRTSNFIKFYKMFRISIHQIFKDIKLNNEDKNYKIRNLIRKREFEEKEHKNLEFYKQIGEIKETVEILKNKLDEKLRNAKVQEDITVSVMQKEQEKPKERSWRSKEVSPSQDTSTNSKPPIFIPKKTLSSSIPIHREYQPKSVNRNIPTFEDFIATQKSTEKSSEKEVMFTDKPNVYVPPHLRKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG8</accession>
    <name>A0A4Q9LTG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0994p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000994">
        <property type="protein sequence ID" value="TBU11889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0994p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8119" checksum="9B0A21812EA4D4A9" modified="2019-07-31" version="1">MLVEENKKNKINAANDADEEHLQENSSPPILRYNNLLYLAIAEGKRPMTLLIVLDSVTDDVEEISHIVLFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI0</accession>
    <name>A0A4Q9LTI0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0978p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000978">
        <property type="protein sequence ID" value="TBU11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0978p0010"/>
    <dbReference type="OrthoDB" id="2196026at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="89"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="323"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="620" mass="71123" checksum="914363C01B60C322" modified="2019-07-31" version="1" fragment="single">KLEKTDMKRNRNNIQAIIELKSLHDIDNYKTKNIISSAMYRKKNNISFLGSKNILPIFNFESLNIPFKFLDILNSKKIFRPTPIQSQVIPILLSCNNVVGVSETGTGKTLAYGIPVILFANTFKELSTIILTPTRELCIQIYENIKLFARPYNLNVCSFYGGTYLLNDLKKIKKNPNIVIATPGRLIDIMKTNKGKYFNVSNVKTLIIDEIDRMIDFGFLPQINQIISNIKNTDLKKAENLNNPNFRKDTNSVDCKNTNLKNFECLPRSSFVVGAFSATTSYKVNSFMLKNFKNIFSVTVGKKYLSLPTTITHFIFILKKTDKFSKLLSFLNKNQIKEDSKNDESFLIFVNKKETSEDLSQKLNNLGYLTLSLNGNKDQNDRESIINSFRNKVCNILISTSLCSRGLDIDGLKNVINYDCPQTKEDFVHQVGRTGRFMEGKAYTFICEEERKFSVNIYEVLNQNDCIDIEEVNDLNNMECTNECGIVGRIENGIEIGKVENLDKLEGKPNIKVYGFNNLRYFVEEYLDLIEKGEETIFKGYKGRGLNKLTSQLEGKKRVETRIMKNEICNENENFVFESKIETNNKVSMIKKIVNEMAVKVSETLPDTKDKYDDSKRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ6</accession>
    <name>A0A4Q9LTJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1497p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001497">
        <property type="protein sequence ID" value="TBU10880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1497p0020"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12373" checksum="D4BABDEF88CE6C80" modified="2019-07-31" version="1">MSKPNKTTSEQKKRKQKKEKTNHKVTPLTLERLPRPGKKTMLSTKNEKVLFARSIVTEICGLSPYEKKALEYLRKDKDRRCKKFLKSRLGTLRTAKKKLEALSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU8</accession>
    <name>A0A4Q9LTU8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0918p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000918">
        <property type="protein sequence ID" value="TBU12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0918p0030"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="342"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="453" mass="52197" checksum="04ED6376401CE531" modified="2019-07-31" version="1">MKDTEMFTTILHLTPKDPLKATTLLRSHLNTLTPTSEPTTPSAEIFFHAVQLTNLIKQKKYDTVLEISITLIKKHFHISNIFQHNYDYITLIDQMYSSPCLRHFDFPLSIILLCFYNSFKKIHSTKNSQIFFILLNLNKEIQNTESVGILTVVVLDILIKNHLYSQALLLINKCNYTLRGACQLSGSKTIVDSFSLGDNIEFGVLQEDKDSKIENLHENIKDSKLGNKNQHKTQNTSQSTFISTNLLHLFFYYKGLACLYLGDYKLSIQSFHSSFMLSKNINFKKILEKYTIIANLLISNISYLKKVKWTKELKSYYKLYVCLKDGCSVRFAHILKGCEYEFKKDKVLLLIRRMWVRILMEGLRKIGMVYERIGLSDVGVKLNIEREDVEFIVMKGVKAKVLEGWIEGDVLCVGGGFRERGGYKIREALDVGDVVIDYNTSSNYKGVSNKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU41</accession>
    <name>A0A4Q9LU41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0878p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000878">
        <property type="protein sequence ID" value="TBU12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0878p0030"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16782" checksum="CE59BC97D50F57E9" modified="2019-07-31" version="1">MIIDSKTIYVQQDNAKPHFSDNDADIVALGSADDWNIKFKVQLANSPNLNVLGLGFFNSIQSLQYQASPHTIDELINLVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHLSKVKLRREGRLLEKYDCSKEEYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB5</accession>
    <name>A0A4Q9LUB5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0880p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000880">
        <property type="protein sequence ID" value="TBU12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0880p0020"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="35423" checksum="84B4CD7B66C3EB28" modified="2019-07-31" version="1" fragment="single">MKKLITSALPYVNNLPHLGNIVGCVLSADVYTRFCKKRGQKAIHICGTDEYGTATEMTAIEQNLHPKEIVDKNSVIHKNIYDWFEIHFDHFGRTTDDDHVIFTQKIFKEIYRENYFEEKTSEQYFCLKCELFLADRYLLGTCPSCSSERARGDQCDDCGYLVKALELKLPKCSICKEEPVIRKTKHLYLRLDLLKPQIKKFIEEKSESWSDNAKAIANHWINLDLHSRSMTRDLKYRWGVGVPVEGFEDKVLYVWFDAPIGYLTFTKKCLKEEYDSFVDDCVWYQFMGKDNVPFHSIIFPGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV13</accession>
    <name>A0A4Q9LV13_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1192p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001192">
        <property type="protein sequence ID" value="TBU11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV13"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1192p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="611" mass="71988" checksum="36EACFA487B321A4" modified="2019-07-31" version="1">MKEISFLKQLSHPNIISGTLFSNGYINYLEMRFVEFDLTEYILKQVLDALYYLKNKQIIHNDLKHNNILIDEYLDIKICDFGISCYKKELAFPFKTLPPTDLEKYIVYSPELKKSEEYDEQSDMYSFVDSLLMSAYFDFLYENMFCFGELKDFEIKTETKFISKKDKILTIIGENENKIDIFCCCHILTSLRYTSKSKKLNLGENDYSNSTHTFNQITTKRFLYSLRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYKARKNELVSVSDSSRWLKKENIRPRDEAVFCYIQDRNVFWRADNVCQHCGKSGKTVDHLATRYENEVVRCLHLLLLNRYNFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANDVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESRLNAEESWERASMGVIMRSEMHEELKPYLKEEKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKVVEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH9</accession>
    <name>A0A4Q9LVH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0676p0020</name>
        <name evidence="2" type="ORF">CWI38_0702p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000676">
        <property type="protein sequence ID" value="TBU01578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000702">
        <property type="protein sequence ID" value="TBU12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0676p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0702p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="108" mass="12927" checksum="0C226C674343E865" modified="2019-07-31" version="1">MDIDTNYYKCLLNLVKNDENKKELKSLIETLLETKTEKYILNNNLDFKKVGKWLRVNYKGENTLCRIVGCSDNKYIALFEDTTDFVVLDESRKEKKQKEWNLFKNQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI4</accession>
    <name>A0A4Q9LVI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1113p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001113">
        <property type="protein sequence ID" value="TBU11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1113p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="826" mass="97512" checksum="0037788C1DB443B1" modified="2019-07-31" version="1">MLYLCGIVGLKFDILIYDENECINGNSSNDKCDIINEMNEKCKYGIDRDVCIGNNTCDATEKNEKSKYVSDMDVCIGNNTCDETEKRTYVRAMDVCRDNEVCDAIKETEKCIYVSKSDAIMNYDTFKEYLKEKNILIENILVCNMEYPNKRFIEFELLERNNTNVFFFIGKVRKRDIEMFNGVLQEEFLNNSWENLFGEDFFKIMNFLMIFKAKKGKKNCKFLEEITYTFINGKYNNYFGNLLFSSDFGPFKIDNWLLINIFNSAYVLFSIKRNSCTEIFSNSSENSDTLNIRYNESNINDIELFICKDLFKFISGEYNGLKLSYFILFIFKSIKISTCTILKDVSEGLCNYYKFSIYFPENVESLFINTKYFYTEFLDFCMNFSFCRNIKKIYVKSEYFTDEICIILRKFLGLQKVIFNIQNMRYIDIDPILFFSIYRKLTYLEIKCVHIVDPIFPLSKIILSDSFELRIQCYEFVTCEDYNFRKKKRLLKNVLSNMNVEVMNFSINDLISSLKEFSNLNTIRVKNYGISKVCIISTETIDIIKKLNEISLYGFYICSDFFKCCIESRKIIQIRLISCLIEFTEKNLDLNESLNILAIQTCKINNCKYLLKNISKFKKLVCLEFNKCGLLKENIVCSNKDIEISNFQTINTKNDNSSDLIPSIKELKIIHTCLSLEYLHSNLNILYLSKISLEKVDLSLEDMKILNRFRFLKHIILIKINLKRNDIKDSNESIFLSNSVLNLNVIVFKNIVLTSRDIYCISKMKNLEHISFTNINFRKYNVSLRNISLRVMKNLKSIWIKKCDLLDEEYWYLVENFSGKTIYLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI8</accession>
    <name>A0A4Q9LVI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0657p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000657">
        <property type="protein sequence ID" value="TBU12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0657p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="284" mass="32671" checksum="A87B55EB4918D7D4" modified="2019-07-31" version="1" fragment="single">MGIRKYVIRECKNDQQIPQPSSYTPSTIINNTSIPPSEANTNTKVCLLKTIPSPYNPMHSSTVTPRPDIAASGPNLYTIPISERLVAERQEFIRCVLFAKQSYYNEKFSSTHTIDKRLGIATCLAEPCSLTDTTRFISLREKYLIVVRTRKPPNELVDSTVLDLINRIVGEYADSHVPMTITDIARIIQTAQVCYGHETRKERPISAWKESIEKLSSSQTKSLKKIMREFNLDLNKTNDLSEALQFRKENRMFELFRGRYYRGLSERVESEHVVNRDEIVSFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV3</accession>
    <name>A0A4Q9LVV3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0645p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000645">
        <property type="protein sequence ID" value="TBU12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0645p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="8134" checksum="50D59A046A625B7A" modified="2019-07-31" version="1">MYCTENKLGVSHSDGNFSIQDAKNSTQISNYENPPSLFFECLRKEAIFKNEPYKKTRPNDGCVRKKNDTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY2</accession>
    <name>A0A4Q9LVY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0594p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000594">
        <property type="protein sequence ID" value="TBU12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0594p0030"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="160"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="244"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="608" mass="69502" checksum="41736BEA514C068E" modified="2019-07-31" version="1">MTKDLLEKYFESRNILHILSLFIEKGIDEPFLLCRLKYSDLEKLGVSDYSDRRKVYEIITIIKNELQDNLEENNTLESLVTFISESNSSPIESLSLKSPIRFSTNTHISDLQDSKILQRNRNNLRETVSFHPTVSPREKNITKKGESGMVLDGNQTNKSKITVCVRKKPIDSKDMDMIDIEKNVVTLNEPKVRLDLKKYTEQHVFSFDFVFNTSSKNEEVYCKSVFEIVSYVLNGGNGTVLAYGQTGTGKTHTMFHPHTGIVFRALTDLLNSENILQISFLEIYNEKIFDLLNYRNKIEMREFKGSVFFVDLKQEEANTFEDACKIINHGLNHRRTGITDTNTESSRSHAILKISIKKNTVKNVKINKNSTEEVKYFSKNLKICESEEKKSCKISIEDQSIVFVDLAGSERGNDRKTVASNTKNEGAEINKSLLALKECIRGLDKKFKHLPFRQSKLTQILKNSLIGVSKTCILATINPSVFCVDHSLNTLRYAYRIKGNQKSPKKQISGAPQSFYDKIKNKKSPNKYFIRNSIENTLYRDSSSITTSSLSFNTLKDEIDDVNLAKKRVNCVMHKIKQAISTTEDISIVEVAYDGLIKIENQINDMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW22</accession>
    <name>A0A4Q9LW22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0746p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000746">
        <property type="protein sequence ID" value="TBU12466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0746p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="25927" checksum="AA798DCA3A0B65C5" modified="2019-07-31" version="1">MELELSPHNARILDSLLKTETIIIKISENIIIQELSDSKSLLIQITLFPLFFTEYLQNDLNFSFSFSTPKFFKKGMKSLRIVITDLIISLSWKFNTYNYYKEIYISSTELYSLDFNEIKSINLDLVLLFEIIKYLKSDVIVLKFLENYFIISGENKSEKAVVYMENNFNEILKFPQKNIKTILELMTDTDECMLSIDELKKTACFISKFPEYLLSIFTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA5</accession>
    <name>A0A4Q9LWA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0706p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000706">
        <property type="protein sequence ID" value="TBU12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0706p0050"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="326"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="46262" checksum="029CD479731AEB40" modified="2019-07-31" version="1">MRIIIKNLPNKITELQIRSSFSKFGEITSFLLPLNEKEKPKRFCFIGYSKPNNVVNLMNNSYINNSKISVEEIDNEKYKKYKNGEPDGINIGSDMTNSRVYVTNLPNTSLDIKDEIYKLLKLYGGITNIVNDSFAAIVTFDTHVSALKSLELNNCEFLGVLIKVRMYNNNIEKRFNTFFFDFKSIINQYKSKDKEVLLNLKDSDLGTNISLLESHLIAKTKDFLVANNIDPSCFTERFDKKVLIVKNYDVMGSISDSFDCRVSVSPFGSMALLYFKDEENARKAYKSLNCRRFGDKAVYCDYLPICIQKKKILEENVEIKQKNSVNKLIVKNVPFQADKNEIKRLFSSIVSVVDVRMPVKGDKTSRGFAFVTLKNANDVTKAIEYLGTNTHLYGRRLVIDKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH0</accession>
    <name>A0A4Q9LWH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol 4-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0537p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000537">
        <property type="protein sequence ID" value="TBU13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0537p0010"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00893">
        <property type="entry name" value="PI4Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="301"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="671" mass="79109" checksum="A19CF2DD76FCFE37" modified="2019-07-31" version="1">MKLEYKKDVLVVLPELVHIFFFHTEDITYLGTLETEQNKLCILLIGEIYECDSLREEREKCKRKLIFNPISSFLKYLDCKNILFKNLIYNHLNGYNYLSFKTIKIPKVELIFPNLKGILFYFVKSISWIISDSLFNCLKDYEKIFSNKRFRFKERGRKSRLFYGKSFEKKDLTSNISFFEELIEISKRLKYLHKNMRQKGLEIEIGLVNYNLPAKIYIPFLPTGKYILRILLDHSYILDSAENSPYLIVLEIADEYINRNEIISEETRNVAVILNQLTTLEITKKYEANIIKQKIIENLQNISQNKLYMSSWSTKRETIKSQSVYSNLRGWNIKSMIVKTGNDLRQEMIASQLLTEMINIWKEEKLDIWVLNYGIYLIGSDCGFIETITDAYSIHAIKKRNISKKKSYFLKSYFLTKYGPEHSGEYKRALRNFLISLVGYSLATYILQIKDRHNGNILIGKDGHIIHIDFGFILGDHPGFYRVETAPFKISREYCDLLGNLVNDFKSLFLEGFLSLRKYNDRLCRIIEIMMEKSKVKCLNKNSLIYFRERFKLDLGDKEIEKYVVDLINWIIIIIRFESGLNAEESWERASMGVIMRAEMHEEQTPPLKEEKREEDDAKNFKPRNNTPHISQGGTTLEEPTNNINEESDLEEETKLVKEVEEKCRNFREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK8</accession>
    <name>A0A4Q9LWK8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA polymerase delta catalytic subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0930p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000930">
        <property type="protein sequence ID" value="TBU12030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0930p0030"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="12">
        <location>
            <begin position="226"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="11">
        <location>
            <begin position="473"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="622" mass="71076" checksum="C12378B201A34EFA" modified="2019-07-31" version="1" fragment="single">MTKKTDTDLIFLSTHIDNPPISPNTIKISGITLQGTPLTLHVTDFNPYFYIRPPNPEPKNFISLLSSALTKKMNEKSKSVLLRIEKVYKKSFLYYSPTPVLFYQLFFTNTLLFSQLTKILESGIYIDNVSYTFQVFESNIPLPIRFMIDKELTGMSYIKVTKYKKIKNKNSNQNNSNNETNIDSGCTTTDTNPTNTDKNISNISNISKNNDNTNITKNNTDIPNTSHYIEYITSHTNISHIDSITTLPPLKILSFDIECISKTSSFPSAKIDPVIQIGNIISVDGLISKHIFALDSCADIPNATVHSFTTETELLKEWIIFLIKTDPDILLGYNITNFDFPYLVERSETLKIKEFKFMGRDSSSIRINTNNNTTTVHIQGRMIFDLYVIIKKEYNLRSYTLNSVSEYFLGNTKEDLPYNCMYSLQMGDKETRRRIALYCLKDCLLPLNIFDKLNILINCIEMCRVVGVPIEYLNRGQAIRVFAMICRKAKFMGYVVPVVENTEGEKYEGGYVMDPVKGFYEDCVAVMDFSSLYPSIMISKNLCYSTLVRKKDFKEICGNKNREFEKESVSYEDSIGESELEGMDEEYDKGLDEGVCDKDIDVGVNDRSNDNYHPLNTSTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS5</accession>
    <name>A0A4Q9LWS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERAP1-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0641p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000641">
        <property type="protein sequence ID" value="TBU12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0641p0030"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18639" checksum="8225056D1DC2F75B" modified="2019-07-31" version="1">MMDQWTINEEFPYISVEVVDENHLKLTQERFYLNNANIKEKNQTLMLVALKNKKDILGMSDFKNYPKVNYGAYGFYRVLCNEDLLYKINGMLEEKLLEPRDRLNIINDFFSLTLANNLQFNDFLSFVRYFQDEENYEILSSILEGLNEFQSIFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX1</accession>
    <name>A0A4Q9LWX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0796p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000796">
        <property type="protein sequence ID" value="TBU12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0796p0020"/>
    <dbReference type="OrthoDB" id="2201196at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020703080" evidence="3">
        <location>
            <begin position="20"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="702" mass="79152" checksum="AE95348FB4C0ED5E" modified="2019-07-31" version="1">MKMCIILLIMVLKCQIVIIDDIGMKGNTGEEYNGSLFKENLPLNDTLSKLYDNGRGVNDTYKGNTPLGDTGPFSGGNKTPYSGNNPLSDTGPFSGGNMTPYSGNPLGDMGPFSGGNMTPYSGNNPLDYLKNYKGVLDNSGDDKGAKPPYMGNTLLGDPGLFKIPSNSNNIPYKANTPLSDPGKPNFNKNTSKNKKPMENKPKYSPQSDDLQQIPIYSFQDIFNMKNKLNNGFSKNSNSNQNTEKDRNNSIDRDNNRDRDKGNDRDESRDRDKGNDKDKDRDKERKDNASNTDGKNNSNLNILENREPSYKSKNVENGNIKPKSSNSTDNSYNHKGNNTNISVLDISDTKVVKDNDENTDLEIYKKFKKPIINTPSPIDISNEDYLGNIGNEESKSSLNKEISYNEGNGNNTGVDNSRDIRPKESNSTISYTINVNEGGSDVPKHENIPDMPSITHPYLSVDSLTPIHPYVPPSDSGSHPYLSANIDTLPNSDIFTQKKLMDKEKSNLKDANVARSSFLQLKYDESKNRLDSLKNSLNDLTSKLSILQEKMKERGMENDNLKETLRNNRNHLKNSKTNLGKIAHEKHKIEAELRLDNNEIAKLNKKIDDLRNKVETLKAEQNVYRERGLTLDREVLQTDKNIKIEESKTREYKKELESIQVLLNSLNERRSELVGKMSNEESLQSKIWMEMDRIRRSELSYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX12</accession>
    <name>A0A4Q9LX12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0868p0010</name>
        <name evidence="4" type="ORF">CWI38_0474p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000868">
        <property type="protein sequence ID" value="TBU00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000474">
        <property type="protein sequence ID" value="TBU13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0868p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0474p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033833882" evidence="2">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="89" mass="9085" checksum="9971F135C3036AC6" modified="2019-07-31" version="1">MQKIYHILLIILLCVINIVYAEPSKSSSSKKESSSTKEGNSTGGANGTSGANGTGGTSASGNSSAIMKEGMSGSAVTAHFRRAELTLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA6</accession>
    <name>A0A4Q9LXA6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0574p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="PITK01000574">
        <property type="protein sequence ID" value="TBU12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0574p0030"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="451"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="595" mass="67979" checksum="B0B795B0D7AC00EB" modified="2019-07-31" version="1">MMKKNTKYLVGSILLGYAGYKTIKEGYHFYRNHELEKKYKKKPSLSWAPLSRNESINRMKSKEFDLLIVGGGASGSGCALDAVTRGLSVALVDAGDFGCETSSKSTKLLHGGIRYLEKAMKYFDLSQFKLVFEALHERKHIINIAPYLANKLPIMLPVYNKIMVPYFWVGLKLYDWLSGTKSIGSSYFIGKSKTIEIFPRIKKDNLSGSVIYYDGQMDDSRLNLMLALTSSYHGAVISNYVEVKNILKENNISVGATCTDKITGETFKIKSKGIINTTGPFTDSIRKDTNKELRNIVVPSSGTHIVLPKEFGPKNMGFVFPQTSDGRILFFIPWKNKLIAGTTDNKCSVESNPKPSNDEINFLIDETKHLISYPDDLEKNTILSAWKGIRPLVKDPSKKNTESLARNHIIEVTSKRTITLSGGKWTTYRRMAEDAINKAIKTFKLNTKQPCVTKFIPLLGSHTYNHEMLYRIQRDLKVPLKVAKNWVSNYGDRAYKLRDYIKNDKINKISSIYDITEEDVEYTIDNEMAIKISDFILRRYRIGFIDVKEAYYMIDKVSKIMKRKFCWSHKQELVERKEAVESLKSLGLEFCMKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ6</accession>
    <name>A0A4Q9LXQ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0388p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000388">
        <property type="protein sequence ID" value="TBU13578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0388p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF35">
        <property type="entry name" value="RX N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="778" mass="91805" checksum="017579F2C52BE1FC" modified="2019-07-31" version="1">MNICALPTTKKNSYYIFFSNCIRIVSTLLIFRLIISERCRYYFSTNENSEILFFREENSTIDIVDHEFNLILFSNFNSRSLNKKNLVFRYKKENFLQFEVLNNLLLPNNIKNNNGTIECGFELSYFLKISSDLEELPNKPNSDLFKSMFLTFKFLKVIVNKQLLKFLQALILLISIFDKNKTSNFDFNIKELFNSGFLTELDSYIKKNFIFAILNVFMMKYIFYDENLILLENINNPNDVSFFNEHIPYKSLLINNYNIFCRLENILRNPNISFSFLYLLNEINIKSLIINNNRGFIIPDSEFYFSSFSHNIFKSITISNFNDSSSSFLLRLNAFIGKNIEYLTLKNILVARNVLNLLLNKLNLRGLVLYDVNITGFPICIDDFTYSIKTLDYVDFSFVDISNTWWNDFFRRVNVSTLILFFRSKHAEENFINEFMKIDSMINITYFSMQFYFRKIHPGFVRALSHLQYLKTLKLKGYLAFENVEANLYKAVEDMKELEYLEMCQVNYNIKSLDLMLQAFKIKVLHLENIVLGKETLNLNFFCNHKSITKLVLRKIKICAFCLKEIFKLENLKTLIIQFCVFEPILDSELLIFLSNNIYILDLYGTNLELIKDYDILGKLDNLEYLYLSFCKIFSEYLSNLSVLCNSRLRMLNFEHGALYPSDLNRIQELEILEELNLFCCSFINCSFGKLGNNCKFFESLVNLNLSFVNLTIEDFIYCKNFKSLKKLSIELPAFNLIAIRKCLLCLPLEELATNYIAENDKFKNFCHYFYERGIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR6</accession>
    <name>A0A4Q9LXR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0510p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000510">
        <property type="protein sequence ID" value="TBU13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0510p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020485328" evidence="1">
        <location>
            <begin position="17"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="656" mass="77969" checksum="254ED24C81182F3B" modified="2019-07-31" version="1">MKVNFFWLVFGSKCLCAELTAMKQAYSQCIKSDKIKIGECINDIVHNSIIKQKEAYISCENKKYFVFYDIKQENSELLKDIITVINNQNTPFYCSSLKYNPKEIFGPRKIIESHYNFLNSSNYFKEKTDISSCDDNVCHIFDKKGMCFYRRVKDRISKTFKVFGEFTLTGSRLKHIASKIEKSFSKSDHMGYRNEDCYIATFSNEKLSNLDISIISNLLQEIYEQNNQVLNNVIIYIPDFLKTDINQYEEHLTSQGIEFNTLLFKYKIKGHVSMLSSDSLRTLKHFKSYNINYNSMISILLESFQLLPINQSKDGCVDRFFRYLKGKRVYFDGYQTRDLVNMKVKNEEFVSLNSLFYEFRYERYFTDDEMEQNLLRTYEIYRLYYKNKLNDCTFEYFVVYDGRGLLKYVASDIFQFLKVYKRCDTRNIDFYMILKTLEKYFLNENSMNDYNNIYRLHTLGTEEPIFISEDHIFETSINITENTTPFNEKLNLLFDKLKTEIVKYFEGISKSAIKYYNYKETTHDFDDTIPLIYFDGRIDSSEMFDDLENYYRGKYSNGSTIQYALERTFIEGKKRVKSLQDIESMEYSINNEIFLIIDIEEDLYIAKNEISLVLLFDEYNSCLRISVANSSLYNITHLLNLTKIIKKIAKESRKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF6</accession>
    <name>A0A4Q9LYF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin/thiamine adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0311p0050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000311">
        <property type="protein sequence ID" value="TBU15524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYF6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0311p0050"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004281">
        <property type="entry name" value="PRK05690.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU15524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="28245" checksum="536481EC7B339CC1" modified="2019-07-31" version="1" fragment="single">MLYTSELTNSEIQRYSRQIILPEISVDGQIKIRNSKVLVVGLGGLGSPVVSYLATAGVGTLGLLDYDVVEFSNLQRQTIHSERTVSKDKTKSAFLHLKRLNSRITIREHSCMIGDDNANKIIAQYDIILDCCDNITSRYSINDNCKLLGKKYICASVLKWEGQIFVFADDGPCYRCLFPDPKNDNMLGCAEAGVLGPMCGVIGSLQAVEALKLILDSCKSFLLTYNGYENIFKKVEINQKSERCLVCTEKKIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG8</accession>
    <name>A0A4Q9LYG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0309p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000309">
        <property type="protein sequence ID" value="TBU15683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0309p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020724773" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="36864" checksum="0F1BF1ECFD26597A" modified="2019-07-31" version="1">MFYLLFLYVVRIWMWCAVRENIIEEISKIFSFNKSDNIETFSENNTKADISEVVQNSVIDKSDNIETFSENNSKADISEVFQNSVIEESIQSQTHNEEVEAETSENLLTKEKEREFNDKCRVFFENIVKSILKEVNSCFFEENNEADIQGDVLLKVFKTIYCSKNNLDAKKDDNCTNSETLECPHQKQKKNKQRNELSERRRAKISGKRRSKRINFWKSKYKDLKSKNRKVKIVKVFLKDEGIQCNINDPPQNPSFIPPPPPLDNLRNFENKRSESSNVQKELPKKNASGSFNPDLNSALLKKFEELRSKGRLANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL3</accession>
    <name>A0A4Q9LYL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0558p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000558">
        <property type="protein sequence ID" value="TBU13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0558p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="123" mass="14693" checksum="44DD090623E77815" modified="2019-07-31" version="1">MAYLKKYKATIYQEIGVVRLEAADFFKIDSRMRARFYLPRTELVRGIESLELDTNKTFLALIKSFLKSVGHTQPAKLYNEIEKRKLHSKLYNPRKIAFMYTRIKTDDNIQNNRLDIYILDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL6</accession>
    <name>A0A4Q9LYL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0613p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000613">
        <property type="protein sequence ID" value="TBU12825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0613p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="10430" checksum="53E135C70070A9AF" modified="2019-07-31" version="1">MNIEEYIRYNMLKKIFKTIFFDRRRGVESKRNAEESLKSSEMEVIEISEMLLKIKKSITPHISEEGSTLDEPTIQINKESDLEGETFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT8</accession>
    <name>A0A4Q9LYT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0274p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000274">
        <property type="protein sequence ID" value="TBU17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0274p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="51241" checksum="282493795E59C028" modified="2019-07-31" version="1">MRGSVRKLQNYSFIFCLLAMFILRGNLYTIEEFDKAISTKFKEIYQVNEEILKYFSDSDFYDIRIKDCCMPLELIELLSDLIRSSNTTFFNIFIEYRCKMQRSSKNPENENIFELKKFGANNFAFGINYIDKKNRAPLYKRLQIGVSKKYLKHLLNTLFKVTLVFRKFYTNIIEFANYCYRCSNANYRFMIFDPELGFRNIVGFPDKKILGRYKKSNITYKQVLHTKLKFSGKLSRHSGGMEDVESILKEKNEILLKLQGKYDIKSYWRFLNTLPNAELSVESNTDIFSYNLKIHSSLARQRPCKEVAVCFIRELLVEKDYFIECRLLSENSIKENDFKREYSYNSNFNDQICILKLYFLQNNNEEKIFRLYSSLFKTNEYFEIFTDGEYNITRVVDNVEKSWPSERNASLNEYEWALIVILGEIWLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX5</accession>
    <name>A0A4Q9LYX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit zeta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0280p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000280">
        <property type="protein sequence ID" value="TBU17625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0280p0040"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="524" mass="58375" checksum="73A2391BDB4C1B78" modified="2019-07-31" version="1">MSEAQVTQKGQALLINSSATSALSSFFQSNIGPKGSLKMLCSPSLTLKLTKDGNTLTKEIQFSHPTTILINKASQSISQILGDGTSSFIVMCCEIFNHSCRLFLEDTNIHRICQGIQTGCTLLLQYLSTLAVPISMDSASINYIDNILYEICSNQLNTKMNINIAEILVPIVVKSLKCILVSQSESNQKSFLDINMVEVIKMGEGDIKETRLVKGLVLDHGGRHPLMPTYLENVVVMITNLSLEYEKPEINAQFLYSSAEQRDSLVGSERKFIFQRAKCIAEFAKELKTKNKTLLVISERGIDPISLEVLSNEGVLALRRAKRRNMERLTKMCGGSLISRIEEIKMENMGFCGKVRVENLGEEKFTFIEDVPFGGSCTILVRGCNDFEMERVISGIKSTLKSLSFIIRDKVFIEGGPSLYLKLSKFMESTARNVSEKEVAGCLVLKDVMIKMAKILIKNFDGSVEENIVKVEKGQWERVIDNYIVVNRVIANACVMSVSLLMVDEIIKAGKQLREDNMNGKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ10</accession>
    <name>A0A4Q9LZ10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone H2A/H2B/H3/H4-like centromeric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0185p0010</name>
        <name evidence="8" type="ORF">CWI38_0268p0010</name>
        <name evidence="7" type="ORF">CWI38_1950p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000185">
        <property type="protein sequence ID" value="TBU04082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001950">
        <property type="protein sequence ID" value="TBU10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000268">
        <property type="protein sequence ID" value="TBU17672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ10"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0185p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0268p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1950p0010"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU04082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="145" mass="16671" checksum="646A7F3D86E0D928" modified="2019-07-31" version="1">MARSVKSSKTIISPTKSTQTLRAARKKSLSVKTPIILAPEKKSITRRSRPQSHVLKEIKYYQETSNLLMSRLPFTRLVRQTLFNLKSKQQNIVTRFTKTAIHALQESFEAYVVSLFESAYSCTIHAKRVTLYPSDVRLARKLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ17</accession>
    <name>A0A4Q9LZ17_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0402p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000402">
        <property type="protein sequence ID" value="TBU13537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ17"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0402p0040"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="635" mass="75326" checksum="75D0C8F9929B8DD8" modified="2019-07-31" version="1">MEIFGVSKTYIYGLIKNNTLTIPHKQCPFETEFCISQPIPLLFDEKYKIFYKNKIFNSYVLSEEENVYLLYSVDNKTTMVDKKVILESNTIYTFNITNENEFTRRVELYENNEMFPGIVLKGQVFNDTVMTKYGNGKCIFLDNHPNQKIISVLLYKISGKTYNFIEKVESKDKKHKRIKKAHFLDGSEFKVVAECKNFYLVEKERIRGILLKDMIMNYVNDFVKIKVKDQEWGYVFTRYEIGTSKSKNTELYEGMVGKGVISKICNFGAIVSVNGFKGRLVVSEISSNYIKNWKSHLENIISEKNELTGIIYNVDFEKNRFDFSLKKYELQEKENELNSGIKLQVPFNDKQNIKETEIEVKINEKNKDLSLKSEENKKVDFCTETKRDILKTEEDYLMEIKNMPKSALPIIKYISFKIERNEDVREFYKEFIKKMEGKEKMDLCVSYINYLIFINEENIINEIKRCYTICDKSKNIDFIDIVIQNIKEIKNDLLKLECFKYYFKIKETNKSFKILVEFLLKNGKMEEGCEIIKKNINYNSIGIDLLYKYKTKDLRVRIENLVCGVDGWVSYLKNEWNDIEYVRRLFQRVVDMDWKIKEIVIFYKLWIEFEEENGGDVEVVKSIAREHAERLKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ19</accession>
    <name>A0A4Q9LZ19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0249p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000249">
        <property type="protein sequence ID" value="TBU18225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0249p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="59286" checksum="91E27C77F8CA4C86" modified="2019-07-31" version="1">MNIFIILLFRKILSSRISKEGNKIGFTKDEVKQRPVDRSSTSDNNIKRYLHIIVTNKNQNLIDDTSLAIPYVKKFLEAHLKKIISLIEECIEESIERQKIQRVNDGNLINEKTIYKSICSIYKLNFKKCKEVVYERRLNTLEEKIEIIRSTFKDKVLMKSITERIFHTSLVGLDNLNSVFPQLSIYDSKINENFLTEEIRNNEFLKLIKYVYQINKWECSKYYDNAVLSKENLIVRWGCFNMLLIALCNKYTPENPNNISYRKEVGFFVDLNDYHGPVLFKADDNCIFSKGLITAYTETYRVLLRANSDRDFYISFYLEIQNWLFVFIEDIFPKLGLETFFYTLTLCFPICETEQKEKKSMKFSTKKTNLSHFKNLYTPTRVCLYIYKVDEIIFKEFFVSFLEKNKFKIEISKEEDKSEIFTEMKTNLLHLFSYFFETTMNECFKEEDGVKHLKTKNNILFISEEETALDELKININTDSGLEKEKIECKRGRIKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ43</accession>
    <name>A0A4Q9LZ43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0258p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000258">
        <property type="protein sequence ID" value="TBU18003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0258p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15912" checksum="4E49D63EB79EA9BD" modified="2019-07-31" version="1">MTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEENGAKNFKTKYKARFILQGGTTSEEPTNNINEELDLEEETIVVKEVEENTSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ62</accession>
    <name>A0A4Q9LZ62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0549p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000549">
        <property type="protein sequence ID" value="TBU13045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0549p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="29974" checksum="11225003F7EFB3D4" modified="2019-07-31" version="1">MLFWKTKEFRIAAIVVFGITTVCLIIGCIGYYKAGNAIKDFEEDFKKVSEKLQFKNNVLAFENIRYAVFMNSIKYKFFMICEIHNNNIPLTKPFEEYNRSNISEPIKDSTKKFLTKIRKAFESSNLFSFDTSGFLKVIPNLGFFVRIGLLIRKKHPFLDVYRAFKSIGSLLNNSLENEGPLFIILKIVDDKRVLLNEKYLYSEITGIFCVKKILDFDSLKINGKKFVSSDFIIYIAEKVRKESKDIMDELRNNYFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ71</accession>
    <name>A0A4Q9LZ71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0493p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000493">
        <property type="protein sequence ID" value="TBU13241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0493p0050"/>
    <dbReference type="OrthoDB" id="447743at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="808" mass="92465" checksum="F4FA1FD245AB2182" modified="2019-07-31" version="1">MQNNGLFTLPSPNTPLPSSVEVLHIPEGNRLVGLLTIYDSFYNEKSNSAEDGERRRIATCLTEPCTLTETTDSGRTRKNPNELVDSKILDLINRVVAAYIKQAAQVCYDEAKSKEMPRFAWKENIESKMSKLVLSKDLLEKARFNLNMKSETDLSEALKKITMHESRKKFGKENRMFELFRGRFYRGLSDRVESEHVVCRDEIDDYLIPFVSDNPPTTFPFLDDFVRGSDYRPITFMSNLYKLTTKCVTKVVQLEVERRGLLAENQLGAVRGGQGAKEQALLNIALNKEYGNNLKATWIDVKNAYGSIDHAYLTQCIENLNLPDRFLKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMNPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIELEINKEKSATNDKCCEDTAALLEGVSVYKYLGIIEDSRGIPTCNSFEIVQSKLISRVERLLLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSKHMLLKLKIVWKKSKEISTRRAAIFKVENNNKIQLALIKGFLKVKYRLVEEVTKKSLEESQLAKLFNEIEKRKLHSKLYIARKNELVSVRNIRPQNEAVFCYIQDRNVFWGADGMCQHCGKSSKTIRVDTRIKTDITLIEVGITSQDSLQIVETEKLRKYNLLANELGLIYKCNVEIILYVMTWDCITVETISFDRRRELEPRLYAEESYERAELNGAKHLKGKNDTPLISEGGTTVKEPTININDESDLEEETKVVKMMERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG7</accession>
    <name>A0A4Q9LZG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0465p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000465">
        <property type="protein sequence ID" value="TBU13331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0465p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="66" mass="7647" checksum="88B19161DD86A412" modified="2019-07-31" version="1" fragment="single">LINCVQDAFHQFEVNTLDNIFTTLQACMESIMLADRGNSYKILYLSKGKLRREGRLLEKYVCSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL4</accession>
    <name>A0A4Q9LZL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0342p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000342">
        <property type="protein sequence ID" value="TBU13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0342p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="696" mass="76193" checksum="C3B7FE5E282417A9" modified="2019-07-31" version="1">MTIVIIVVTNGLTGEDYLLFGMWKVKMNDKDDHESCDGDVGVGDVDACDDKDDHDSCEGATEGEDDSDIIWYTEYDDDDCGYDDGNVDGDDHDSCDGEGEDDTDGTRDIKYDSDNWGYDEGSDDRDDHESCDGATEGVDGSEGIERTERDNDDCAYEDDNDDGDDQESCDGFGDEVYNLEVIFESDDDDAVYNNGEDNREGSIVCNDKEEDGVGIDGNDSGEVNIENISEGEIGEEEDGKVQREGEIDNDDGKYDSIEYEAVIDFGMGILALMINILFLKILGNKKIFGMSLKAVEMMIEAELLLKKLGFAVNYAYGKKLKVLMVGIGGNSGVVSIKTEEYKYLRDCDILEDIWEDFNSEEVSDCNNGVFENKNSGNFETFDERGDGFDKIDEDGKCGKGSKDCEDCKGDEVDKHGETRKCGKVGKFGKVVERLERDDLKDNWVECGNCGNSVELIVIIGLIVVIGFVEIIVLIEWSLKIGLVIEGIGLADLLVAIEAFDLVEPIVLFVVIVLVEPIVLFEVSMLVEIIEIIGLIVVIMIEMIEVIVVIVLVEPIDLVLVGKGDEVFNRNDVCGFGGKSDGVSNDMSDSKVCGSSGERCFLKVGKCDECVNCAECNGIFEGVVCRVCKGTYRKLDLYCGKRGGHCSKCEGFDGKCGCNGNRGKIGRFVTCGELDGRCDSGSCDNCNDFPETFGECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY4</accession>
    <name>A0A4Q9LZY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0185p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000185">
        <property type="protein sequence ID" value="TBU19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0185p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="18161" checksum="9A43D5EFFB267D82" modified="2019-07-31" version="1">MKMNLNKYTDKKIKLKGFLKVKYRLVEEHVGVSDSSRWLKRGNIRLRKEAVFCYIQDKNTVDHLATRCEKMLGHDYTRRHNEVFKSSKRIRSHLVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDMKKNKIALIEVGITSQDSLQIVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M049</accession>
    <name>A0A4Q9M049_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0430p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000430">
        <property type="protein sequence ID" value="TBU13440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M049"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0430p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="25221" checksum="F14D181DAAADDE6A" modified="2019-07-31" version="1">MLGHDYTRRHNEVVRCLHLLLLNIYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDEIPMNVEAYIQSIVLKKTVHTISFDRRRALDIEPNAEESWGKAPIMYLEPTPPLKQAKNEEDHVKHVKTKNEQPLISKGGTPLEEFTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A9</accession>
    <name>A0A4Q9M0A9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0145p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000145">
        <property type="protein sequence ID" value="TBU20029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0145p0020"/>
    <dbReference type="OrthoDB" id="630633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF35">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="403" mass="46877" checksum="C66BCB4A6590410C" modified="2019-07-31" version="1">MQENNSKEKEKLLRCFLFSYKINGIRISADDYYYTDCKVLGYKFNISNARSCISTIQTTNCSIFNILNAEKKDEIKYIEFERLTLSKEYIECLEKNLCLESLTLVKCVYSDGFGFLDHLLEKFSELKILGIIGFNLSNRFLNNINLLMLESLDLSQCKYCENIDNCKMQGMKKIEEFRMDNSCINHKVIISIIESSTLKILSLKGANVARLRFSMCFIQREKINQILDLSAKFIQYIIFLFYILKNLVEFDLSQNTFNKDILSQLSVFEKLESFDLSNCCNLTGGFLGTLSNKALCKSLKTLNITGNKLIFSDILNIGLFQNLVYLIFSFDNKMFYEISKSYQFYKVSDLETLVLTFTNVNTDIFRFIATLFPSIKNIKFQQCNIEEDTLRSIKMKGINFEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E6</accession>
    <name>A0A4Q9M0E6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0132p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000132">
        <property type="protein sequence ID" value="TBU20104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0132p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21987" checksum="D26B669B1C4AB616" modified="2019-07-31" version="1">MKNDYITVLKSLINTLASVSFVIFYHTNIEIRSIVSSLFLNIVNPLLILLKIYFNKKNTKKRKYKNFSIEFLLFIYILELTMIVILCISLDVHIVLFVAYFCSIFVSNICTFVIPKKQVRNIPLRQSKSLFQISSMEYDYIVKNNILLHRNEIIQIIDVNGNDVVVRKSNGEEFQVKKWFIKDGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P1</accession>
    <name>A0A4Q9M0P1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit D of V-type proton ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0079p0020</name>
        <name evidence="6" type="ORF">CWI38_0111p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000079">
        <property type="protein sequence ID" value="TBU04855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0P1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0079p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0020"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="207" mass="24258" checksum="5B2CC8C9F773E485" modified="2019-07-31" version="1">MACDQRFQIFATRMNLVITMTRLKSAERGHMLLKRKSDALQKRYREIQLQLEEERKKVSKMFRQAYISISEAEFHGGNFKMFIHECKKVPINVQVSIDQVSGVTLPSFTINELSLRPLIFLDTCGKSLNKCRQNFISVFKLLIEVATLQNSFKILNEVLKSTNRRVNALEFLLIPKLNNTISYINAELDEHDREEFFRLKTIQKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P5</accession>
    <name>A0A4Q9M0P5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_0111p0060</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0P5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0060"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="780" mass="88979" checksum="8B32377E447E83AA" modified="2019-07-31" version="1">MIFTVDDVPIYFPYSSIYPEQLNYIKELINLLKTTGHSLIEMPSGTGKTIALLSASVSFQMYLKKNNKPSFKIAYCSRTVPEIDKALKELENLYEFINKHEKINFLGIGLASRKHLCINPKAKIDTDRICRLLTAPWSITKCDFLENLEKFESFTSGVYSIEKLKLLSIEKSICPYFLARKLLPLSDCIIYTYNYLLDPHISDIVSKSLPSNTLVIFDEAHNIDNSAIEALTIELKRYDLDVSTKCIKIIENKIKEMKLNSYKILETEYLKLKNNLLKNTSNISESIPPDFNECEFEFVPGNLRNAIHFVSVLKRLIEFFKTRLKSTHLSTETPINFSKAIKETLLLDRKTLTFTSYRFNILISTLKSDEDLRNLKKVVDFITLLSLHNKGFSVIYEPYDTSGLFSPVLTLSCLDSSIVFKKIFKRFSTVVITSGTLSPISMYPKILGFVPVKSVEIGVTLARNSVLPLIITKGNDQMIVKAQEIGKQDNKIDPKTAVTTSFSLRSDPSIVRNYGSLVIEFSKVVPDGMVVFFPSYLYMEEIVTLWCEMGVITEISKNKLVFCESVDNLESEKALENYRLCCENGRGGVLFCIARGKVSEGVDFSGCWGRCCIVIGVPFQYVLSVKLKKRLEFLRSLGIKESDFLNFDAMRQCAQCLGRVLRSKNDYGLMVMADHRFEKSDKKNKLPKWILSCMEDGCSNLSVDMAINIARRFFREMAQEFDMGKCVLEESEIVETFSCNERRGLELEENSQESFTGASLNVIQRSELQKKTFFLKPIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L4</accession>
    <name>A0A4Q9M1L4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0278p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000278">
        <property type="protein sequence ID" value="TBU17631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0278p0030"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="23657" checksum="E9D802C714114A99" modified="2019-07-31" version="1">MTHEIPTSWKRHCITPIPKGEGDYRPISLIEKTRKLLEKIILSKISFKIRKQLAGFQEKHSTLNHALFLVNLLRTSNEGMICVTLDIKKAYDTVDRNKLYEKLLKFQKLSLLDTQLIASLVENNQYTIKKATTELFKAAVVGLPQGSIISPSPFNVFIDDIFSYILRNLRKGILLYADDIIIFASTVSQLTDMINSIENHAKDNNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N4</accession>
    <name>A0A4Q9M1N4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0181p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000181">
        <property type="protein sequence ID" value="TBU19878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1N4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0181p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="75762" checksum="5A65600AD70A77D1" modified="2019-07-31" version="1" fragment="single">TTNPKFYVGHLISKEVFEYMIEILCDINRINFKLPAFLYIQLINGIIGLKPETNFYFRSLLSRLNYWAFTGNHLNEIIENKNKLEFDNSFTKQFFYMTAFISYLNYLNISVTFLNSKMILSSSSITNYNTYPSKEKLDNRYNLIFEDKTLMVFFTNINEHNKLLYEWMFLEMDNIETITFLDLKSLNYINIEKCINSLLYKENMSLKITECLNIKNWIRKINKFRVKKLRKMKLEDIHLTLEDLSSFLEFKNIDSIKFDSCSFDEGEISGEFTFEFSCIQINNMKICNPVVSFLKKAFFRLLYLKNVEFINSFGLLNTFSDTKAYKYAHVIELTDLNLNNNFFDLLFYFKNLVLIEIKSVENVSFKIKDKEGLELIRLKNILIKDCGLPDETSNIWFISGLGCLILYRINNISAFFNNLKDKKNTESLEILKIKDSPLSHSDIENISKFSNLNILKLHSCNLDSSHLIYIKKVTSHAEFRKIILTNNKIYEVPGECKGIFKNLMFAILNNCGLCAGSISLLFEEATISYIQVLDFSYNSLNRNDLIFISAFKKLVVLKINGVKLEGDAELDNLTLKGLTKNLKYLEIKQLNISTKDIEALAKFTVLNELKISEDSYKLLKKTNIEIPCRNIRIGKKKDYDFIDGMETDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S2</accession>
    <name>A0A4Q9M1S2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0271p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000271">
        <property type="protein sequence ID" value="TBU17663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0271p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="11415" checksum="BB90A41DD8864B25" modified="2019-07-31" version="1">MSRTIISDADSIASDSEDGEIGGDTSSDDSIIITHRRKRLRIESESSISSSEAEETPTFTNIPPTNVFSKATNNFFETPGPRCAPPPDASPLTYFNLFFYHITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M270</accession>
    <name>A0A4Q9M270_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0136p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M270"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0050"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="7">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="172"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="49559" checksum="BA77CDDEFF32CE10" modified="2019-07-31" version="1">MDEKMFNILKKNKFRNNIEIRPVKIYKEENLFYLKSSDKQNYVKHRLNQMKESFKEVLNITEFYSINHQSHVSFYTIGMVLIHTSTKLTNDSLYVVSNIDDSNDVLVKLNVKYLKKYSFFPGQIIVIFGKNPNGNEIIAEEIHCIPTISYSSAVEDEENLYSKNYENGPISVCCFSGPFWNESTKFESLDLILEKIYDVLILFGPFVDSKMTAKYESSPQEIFTDEILVRIEKYVRKGMNLKVILIPHPEDVFTVGIFPHSFTFLNDKKLDDRILMFSNPSLFYINEFLFGLSTSDILLSLSSEELFCNQENEKADKCSDMLFCNDRISRICHHLIYQKSFVPVFPSKSPICYEKHNYLDMDVSPDFLIQCSKLITFEKQIGPTVVCNIGSQSTPDNKHYIEISLKSAKESNGKRYDISFLNLKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G4</accession>
    <name>A0A4Q9M2G4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0215p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000215">
        <property type="protein sequence ID" value="TBU19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0215p0050"/>
    <dbReference type="OrthoDB" id="10650070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="103" mass="12128" checksum="F92D5C7D685FAE12" modified="2019-07-31" version="1">MGTINFTPILPQEILYIEYVRVIVDTRIKTDVKIRNNKPDIFILDKKKNKITFIEVAETEKLRKYDLLVHKLDIIYKCSVEIISYVIYRGGIVINTIKISRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J2</accession>
    <name>A0A4Q9M2J2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0845p0010</name>
        <name evidence="10" type="ORF">CWI38_0005p0160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000845">
        <property type="protein sequence ID" value="TBU00965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2J2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0845p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0160"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU00965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="258" mass="28436" checksum="7F62F49F6F370DA6" modified="2019-07-31" version="1">MNDFKKGTDDVIPSKKQVPPFKKQFKTPKPAEEWIPATDLGRLVKDNRITLDEIFKHSMRIKEPEIVNFLVGSKLKEEILCIKSVQKQTKAGQRTRMKVVMAVGDGQGYVGLGSKSAKELAVAIRGAVARAKCALRPVRLGYWGSSYGEPHTVPCKVTGKCGSVAIKLIPAPKGSGIRAGTIPRKIFQLAGVKDVFTISRGQTSTTQNFAGATIAALDQASSFFVPSMWEKKNEDQNPLLKHSKVLENIEEKWRFAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J3</accession>
    <name>A0A4Q9M2J3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0004p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU20994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12848" checksum="AC4BEA2F7A8AF34E" modified="2019-07-31" version="1" fragment="single">IHCFNKLESLNLYLDEDLIGKEKCSTVLFRSAKDLNLLTFVCTKFNRYGYNFIFELKSLAYFNLYGCEIENLSIFRFKRNNFLALKLDISLSCDEKLNSNLKIVYEKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J6</accession>
    <name>A0A4Q9M2J6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0177p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000177">
        <property type="protein sequence ID" value="TBU19902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0177p0030"/>
    <dbReference type="OrthoDB" id="7697409at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="403"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1066" mass="122944" checksum="2710DCCC4C3A5638" modified="2019-07-31" version="1">MGRRKKVDSENIKNEKIKAILMCDVDVAMLSERLPSPPTFYNTTHQLSSSINGMTNLNTDAILEENRLMVLHSILDSVIVVEQEWPRYAILAVQKRFERMPRNGWPATLRYYNEKFGCTLDIDAFKKLAQNEAEREIRQEENGERRRIATCLTEPCTLTDTTEYINLGDKFLSKINEISEKEIGKGVVRTRKLLSELVDSKVLDLINRIIGEYADSYVPMTITTVARIIQAAQVCYDEATQNLESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIIREFNLNLSSVTNLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIMSFWSTMWNKNDDTVTYDDYFIRFVSDNHPTTFPSLKLTTLHKHNYDIRKVICLEGTPQADWFYCGLTYLIPKGIPQRGSDYRPITYMPNLYKLTTKCVTKVVQLEVERRELLAENQLGAVRGVQEAKEQALLNIAIKKEYGNNLKATWIDFEKANDSMDHAYLTQCIKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTDEAKKFLKVIGLEINKEKSATNDTSCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFKEVQRQLIARVERLCHTRLNAKNLFSAIKHHAISLINYHIGVLRLEPADFSKLDDAVRAIFVKNKIHLRPGCKERFYHPRTELGRGLHTISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELLSVSDSSRWLKRGNIRPQNEAVFCYIQNRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGYDYSRSHNEVVRCIHLLLLNRYKFKASKRITSHSVQEILDNEYARIRVDTRIKTDVKIRNNRPDIFILDQKKNKITLIEVGITSQDSLQIVETEKLRQYDLLANELGLIYKCSDGIVTKYHKSHLKRLQIPMNVEANIQSIILKKTSGLNAGESWERASMGPTPSLKEEKREEDEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3W0</accession>
    <name>A0A4Q9M3W0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0095p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000095">
        <property type="protein sequence ID" value="TBU20291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3W0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0095p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020764895" evidence="1">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="443" mass="52837" checksum="19C011892B0BA268" modified="2019-07-31" version="1">MDLWIGKLQILMLIFYMSTMLTTNDDKYTVCDFDEQLTHVANFFYVKTKEILKKFADSDFYDVKLQERHLAPEINEAICNFVNSSTSTNFNIFFDSDCKIVRSKKNPDILHLLELRKIGKGNFFFEIKSIDRNNKELCYRQRHIVFGNKFLKHLLKNIFNTTLIFRKFYINLMGGLVSSCRYSHSNYRFIIFDPEISFEHVIGLPNKRLAFYSSKNVIAFKSTVATKLKPSGKLPVISDDQDLNLILKEKCKIFQQLNQEYSIKACWRCRNIYKEDIDYNTSNLLHSFYSIITFRTDCIKEFSDNCNNDSLSSNLIKNEYFIEYKATYDAPIESLNFRKEIRIDFSLHKKPYVFTLFLKEHTQFEKKFSLNFSLFSSDELFEILSDYNLNVTNIVDKVAKFEKFFYDFPLENSSVYKYEYFVKNFCKELYRRMLMDKLAIIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Z5</accession>
    <name>A0A4Q9M4Z5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0040p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Z5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9466" checksum="FEEF4121403BD87F" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVEIFSFNQQTGLETRPKSAESCKKLNNEEADGNTQNKKNVKPYILDCVTTVKELTMNINEKSDLEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M506</accession>
    <name>A0A4Q9M506_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0017p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M506"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="268" mass="31828" checksum="B7A9CB2727A678AB" modified="2019-07-31" version="1">MKKIYHLKILQTTMMIFCLNKINRIKNRKIARKQIRGNEAIDTSHIKSNLDIYNNPEELIDIDNPKLPVSKLKLIMEKLKKKLDLGYNYLYKDRLRYKRSLCTRGYQILLELIKYVNQNEKLFWKNSGFSELSDIKNLKDKLLDRIGKFNFCKHSSLFLTYFPGLIHMNFFVENLIKEDINLVKNACLWILLLKYVESLTFISIKDLNTSGICHETYDDIEYEGFEIYTGNKIILCKMKELYETFEAIACQWRLQEINILLAAINNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX33</accession>
    <name>A0A4V2JX33_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1906p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001906">
        <property type="protein sequence ID" value="TBU10252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX33"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1906p0010"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF444">
        <property type="entry name" value="HECT DOMAIN CONTAINING UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="163"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="368" mass="44378" checksum="80EFADACBD46EEF3" modified="2019-07-31" version="1">MFLFSDYSYNFSQRKKYKRQKKNINFELNFFVGFLESRIENNLIDLFVNYTGLETKKLILLWNYYKKLVNLQGKFHLAVKRDSVIDSFIENIRKKQPSEVKTQMWFVHFTAEDGTGIGPTFEFFDLYGSILNENEYFIAFANEENTIVEFDKESHQKIKEIYFYTGIVMAKCIIEDLKIIDFEFYTSLISLRNIEENQLNEYNFTTIVKINSVYKSYDLINNGSKIKVSKKNLEDYIFKMTEFKLFRNTGMFFQELKKRFREIFSEPFYKIFTFDELRSILEGETTLDIDVWKLNTKYSSNCHEDHQVIKWLWQYITERMNTKINELQNLDENSKYGRKAKSNELQNIDENFKIKIFGRNMEERLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX99</accession>
    <name>A0A4V2JX99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1443p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001443">
        <property type="protein sequence ID" value="TBU10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1443p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="88764" checksum="2AB1497BCEA8DFE4" modified="2019-07-31" version="1">MNIGKFFSMLAIWCIGIVGIVALLGVPLKRKSSLVSHDSDIGSIESNLTDIKSLLVRLDSLEQEIAGLKAIMNGEGSRNMRHEIGTKIDLDTKFTDDEKKAEEIHKRLDDEKKEEEIRRDEEHWRNEHNKSNNNSDNGVNSKANLTNTEILENNEEGKSKLPPNEKGEMNEYDPKQFEFYKNYYRNFGYDFLGPGKLVPLKNENSTNSISFTAHSTQNDTNIHDDSNLALLENKKEQRQDDKNADKREENLVLLSSKKDKENNGSNEHEAETANISMTNDKDKPSGEFLSARRDFHGHEALNDSDLAHMQEIDNHEPSLANPGISDGISGITVKNPVSSLKLHVFKSNENEKALHKLSIMQDFPFNIGEMFTSAMKNMINHRKEVENGMNNNEKPKIPVTQPNKPFLPDKIKNVLKTKDLDEKNENLSLQMIPTKNEFDKKDEPMLNYQSFESPPSLSKTEEFPSLKKENKDGLAESKIALKDDLNFKIAEVSPNSLASLQPGIKSEALSNTQSPDQTLKVKSTNEPSSVEVSNEKNTVQDLELGNQVAKSFDHVNNFSIIQSKNSTNGEKGALIILKESDHKSSNLNLPKKDTITENEHKSTNETKVLPTLPKNEIPQIEKTATNIDLQKEFQINELPEPVSLLSSDKKEEERPPKPQVNTNDNTPSLPKEFIQKANEAEQKIFTTSSTGISNKTNSDIKTTSFSPPNHLEILKNVLSDISRPNVSEIQPLADSSDSSDNQDDFIPPKIIPVIKPHSNPKKNSLHQLNHKKSKEGTKSEKKSKFSSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE0</accession>
    <name>A0A4V2JXE0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1194p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001194">
        <property type="protein sequence ID" value="TBU11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1194p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="91538" checksum="8022768E80B4D34A" modified="2019-07-31" version="1">MKRNIIGGIYFIAFLLIGYFDLYSGLEITFRFPDDICEAKCVSGDRRNSDATNDAENNILLPHGGKTDMNKQSKNNINTNICNSIVINDIGIYPIKFEAFLLLENHPNLHILFVLDHVQSSEFRIFDGLMRSYIGYTEKISSRTLLNIFYILNNLKPVRCPIFYQIINILLLNFDSNMNQKENDHFLTKELCVISTKDISFDMVRIFFNQFFHLYISDAQMSNIFSFEMLSDISPTEHESICDGTEKRILSLDHRFLIYFKEDIYSSINRLQLFNTILLLFKIQCIHILYLNEDNLSRFKIFFELILNEIEIIIFKNIEYSINIEIFIVDLLKRINVKQIYFIDPLFEKSILNTQMYAIKPEKIIFLNFVNRESCESFINTPSPSLDNIQRYMMEKFDLDFVKLESSDLENRLQSPKYNLANYNGFKEIYKPESVKQKFELYTFFNYTFPSCEISGLLSDDNSLKNIKIIFSNIFILNIEKFKIFSLENLTSMQLSQCNLSLKALVSIINLPNIKNLEIKKSEIIIPNFKFQYYKTKKSLISLNFIKVKVNSSIFFYNIVNSLNILKNLQLKLLNITSNISKEVILPGKLTKLRSLYLSSYELLKLDKFLLPNLEIIEEITLKNISLNSPGPNNYGILNIKNTKSVTLKSCQINSSEKHFFDLSIIQKLKINACCFVNISLYEIFVQDNFYAIESFELTKIQITENDVSTFALFVNLRYLFIYYCDFIDNAILGIKKEKYANLILFELKYYEEQINFTCILHLQKEFEKHLIIDSSTDLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ7</accession>
    <name>A0A4V2JXJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0902p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000902">
        <property type="protein sequence ID" value="TBU12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0902p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6364" checksum="85C3DFAA95986BD2" modified="2019-07-31" version="1">MTAEDCAKSHALDLIETRQPNDFSKALVKKKEFKKFNKKSLICLKEGQIEKRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM8</accession>
    <name>A0A4V2JXM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0770p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000770">
        <property type="protein sequence ID" value="TBU12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0770p0020"/>
    <dbReference type="OrthoDB" id="2188950at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="14153" checksum="982D5420E0B6FBF9" modified="2019-07-31" version="1">MKNDILEKLCEMYIKDYKIIKKEFDSFYESHISKLKYFNDHMVEIYKYAFIYFVCDVKGGKNKYCKRHLISKNEFENALKETTCKVRKIEANIENRNRKYETVCNLYSIMSSFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN1</accession>
    <name>A0A4V2JXN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0782p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000782">
        <property type="protein sequence ID" value="TBU12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0782p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="25326" checksum="9E556C35DA30A696" modified="2019-07-31" version="1" fragment="single">EVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNGYAEIRVDTRIKTDVKIRNYRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGISIVLKKTVETISFDRRRVLESGLNAEESWERASMGVIMRAEMHEEPIPPLKQASIEENCKNIIPLISQRGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP7</accession>
    <name>A0A4V2JXP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0950p0020</name>
        <name evidence="2" type="ORF">CWI38_0684p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000950">
        <property type="protein sequence ID" value="TBU00616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000684">
        <property type="protein sequence ID" value="TBU12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0950p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0684p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="182" mass="21961" checksum="4BECAE4FB69FB4AC" modified="2019-07-31" version="1">MFFKKKLSLKDNLTLFYLKCKYRIKDLKKSLFKEQLNIKRNKIDYVRYSENENDESYVNLHIKKKKHFFGLKRIRMIILENKNNLEWFNSDESLIRNSMVFLKNASEYIDDSYYEFIEILNNTNPKFDIKYVDQELMNIMSDTTDDMAVSYLNILQNMSEDKEENDILALKIRLDACIESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ8</accession>
    <name>A0A4V2JXQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0667p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000667">
        <property type="protein sequence ID" value="TBU12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0667p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="444" mass="52669" checksum="11ACBA03BFF1E405" modified="2019-07-31" version="1">MKSQLLKEFREFEESPLGKLLKNQYRENNNFGIANIKYWNINNLGLCYSYYTVDNIFDTNSEIFKIANQRGNGIVNMQADKRINFIENIKKWNLVMPPYIFSLYKLKIFKSKYNPGFLARFGLFITKNSSEINFIHKLENLFKELENNIENFGILNATFNHSLVDITLTKPNNNNFDTFKSIKISLNHNDPRAFFIFLLHKANIFDKKNMYGSLLKNIFPDNVLKQMLINRLNFYVKMADEIRDSLSSYIHRIEEFRDILNKIKQRLENEKSLDWVQKELESLVFWYIKTILSILIDQKDDILNYLDNPKTLFDIFKKLISTQEEESTKILEIFDEFQNTNEEVIIKGLNSVKKFLLNFYKDYSEKKFGTTDESNLRGSAKFLQTEIVKKIYDDSTILDLYTNLITIAMKKTDNYSDEIILIVCQIIREVFLFYIRLYEAISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV6</accession>
    <name>A0A4V2JXV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0108p0050</name>
        <name evidence="1" type="ORF">CWI38_0473p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000473">
        <property type="protein sequence ID" value="TBU13302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000108">
        <property type="protein sequence ID" value="TBU20234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0108p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0473p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="13658" checksum="FDA49B08CB3DEB14" modified="2019-07-31" version="1">MQESIDNSNKKARILGILEFLNDLNEERNIYYIYGAIVRKRSDVFSMKVFDDFDLLTQQIDKFKSENKENRLFFESLKRKKCISVLLLDLLKGVNNSIVIIRGVNVQIFRLKIVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY74</accession>
    <name>A0A4V2JY74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0148p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14014" checksum="C425E3DB72C92C65" modified="2019-07-31" version="1">MLKPATYVRSIRSISVRSTRYVSVRSIRYVVLEVLEVLDMLVLEVLDMLVLEVLDMLVLEVLDMLVLEVLDMLVLEVLDMLVLEVLDMLVLEVLDMLVLEALDMLVLEVLVLEVFVLEVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC5</accession>
    <name>A0A4V2JYC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0047p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0060"/>
    <dbReference type="OrthoDB" id="2191705at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1105" mass="131505" checksum="C2367097022E3D0E" modified="2019-07-31" version="1">MNEDFMLYFSIVEKDLENKKYLEIQNKLPTCITFLRNLKQYIVEYKEIHKNKKITDEKIQKIRIVLIIWIMNILSNPFVFKTKENNEILEFVFECVEIISLEKFCVRCIALLLKKSDNCIEIYESNIFGKKVSNHVFFSIINHLSKLVCLSIYFSDENENIVRFFEFDHKNFEQKKKVVKIIFKTNFIKINHSNLIKRRIFKILTNQTLKGVFDSIKILNYIINNLREENMQVSWTLAKCYEKISKFVKNSDKFLLDVFKRDIFANESLYINALTILSFYILNDRILHKENNGIKNLNENINYENEILFYVLNLMSRDKSNDTKVVYLREMCLFFVWCLVKKKRKIPSVIFCEVFINSLLDSNLNCRRGAASIIREFIGRNNLFNGNLYLEIVENDNIFRIQKCFSALESLLCNKNIVKYIKDTKNSKNPKNYEYYGYLNSDVEMCKNEKEKTDIKSEISKSEISDSNLCENIENIISKDLFHSKEVSKEEICETENIENNLFEKKYKSTKNLYICPELLSVCIFKRLIDSVFHYNLEIRIYSSKLLVKHFYKRLVYFKNYLNGNEISLNILKEIFLENNASEIENNNFLKFEIYSAVNTIKKEIFEIRSINTDLNILDFNVLHGIILVCNEILVQEIDLRIILKVFEIKLKKFFGMKNFEDFCKTFLEIFIKILKQGKIINENIFGIKCKNFHTEDTYCDISSHIESQIDNIIFVFDKNILPEYSEFIGKIMCRFSENFRKLSLLGLRRKNNKSYICCNLFNEIDRKLVLEKYLKNIEGNDYNVKSNTVCAIRKWFINYKIEKVKEFMSNEYLKTIENNILLGMENYEVSFSGDVGFFVRKECFLTSLFLEINEDILMEYFIRFMVDKSREFRQICIEIVLNVQNNISSEINQSNTNFYSSNENNIPLVLQSDNNVLEKDDKIENKINEIFESKSSSIKKFLNQYLSFKNELVENLYGDELHFKICFKILDTLNDNFKYEFYQGVLSSWKHSDSSLFNFLFKNLYESRKNLIFFLLKFLDTENSLNHLNKKIKIKRIALPSLIFINEVIDFEINEDNKIYLLNTYLYQSVLNISKKSSNSKILSICELIIEKYKRFLLIDNSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN1</accession>
    <name>A0A4V6MVN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0508p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000508">
        <property type="protein sequence ID" value="TBU13182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN1"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0508p0010"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="295" mass="34907" checksum="A212098759C52E60" modified="2019-07-31" version="1">MTLLGFYFTKEVFIRYDREILKKKKCIVISNHLTNYDWIYIMVVLHSLGMYKDLCIILKESLKKLPIYGYGMRVFGYIFLKRNWSVDREILSEGLNGLKAKDKYFLLLFPEGTFIDKTAHKKSIEFGKKNNIKIDGKEFLPENVLIPRKTGFEMIHDVLKESIDGVIDITLLVSPHHNFPPEEYTIWNIFIKRKYKISLLFLIECIENSDELRDNWIYGNFQRKNNIIESYKQEIIRNPNCCSDIAGFNYFCENNLPESLANYDYKNLYVWSKRSAVIVEMSVVAIFLTLYSLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP8</accession>
    <name>A0A4V6MVP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative actin-like microsporidial-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0092p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0040"/>
    <dbReference type="OrthoDB" id="2194524at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17003">
        <property type="entry name" value="Actin_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="46863" checksum="238791C09E37306F" modified="2019-07-31" version="1">MPQQNILKNFTIPTVDQITTPNKNIQSYFMKSDSSYYVQDKYKYPNYKEETDNFLTISIPTQTALIGSSLFAFEKCNLENFYNQTNINSNIFTSLNFAIKYFDTRLVLPYTSLRDVHLSLCIPDFLTRSEIIALCDYFINLRNCKSILILPVSLSLCFSLNISNCILIMEFSDYFTFTFIEDNCLVDKNIMFKNSSTKKIKPFYIEDATDFVDDFNKMKLYENRSSIYSCNLCSYKNCVRGDTICHIKTEHIVDSNCQCGEVIEDLDEHVATHFIEDFGDIVDLKSTNILENIFFMIENDLSTEKIKKICTNFIFLRNFESNENFYENFCTNLQNEINTKLSKYDVVPKFHVLEDNSLSLLAYKGTNIFSSLECSKEIVMTDKEWNSFRLRILKEKVLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVM1</accession>
    <name>A0A4Q9KVM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative subunit of trafficking protein particle complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_1658p0020</name>
        <name evidence="8" type="ORF">CWI37_2054p0010</name>
        <name evidence="10" type="ORF">CWI38_0541p0040</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002054">
        <property type="protein sequence ID" value="TBT97825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01001658">
        <property type="protein sequence ID" value="TBT98655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000541">
        <property type="protein sequence ID" value="TBU13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVM1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KVM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1658p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2054p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0541p0040"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT97825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT98655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="176" mass="20298" checksum="83CC748918EB5475" modified="2019-07-31" version="1">MDGKSSEKISADFFTHLYGATVKHLLNENEDSNDILINVGEKIGNRLIDDYFYRSNCKKTMNIKEVANNICNTFFPLYLGYSPQLIENNGIFSIKFESFYLLKFIDTSNEEIFSKKNVKFLNIFVGILKSVYSYLSSDKIVFTDNSDKEFIISVSEVQKKENESFVILDTKVNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L130</accession>
    <name>A0A4Q9L130_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0911p0030</name>
        <name evidence="3" type="ORF">CWI38_0224p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000911">
        <property type="protein sequence ID" value="TBU00756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0911p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0030"/>
    <dbReference type="OrthoDB" id="2189195at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="1">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="197" mass="22507" checksum="B87C0E3B03F9C40F" modified="2019-07-31" version="1">MNTIDELINKIRSKKIKKEETTGDIVNKTTGDIVSKTTTDTNTSISNTNTNISNTSTNIDTNDITDTLHKYKESQDIEIITSQVYPTTHTTTDFKNLQSIKNKIQDFIEIKEIKETEKYKIENYLISIVKRIIKYDNIVCGIELIDETGEIKGSLFCETVHIFDIKIGSIVVIENFSLWKINETHLNISSENIKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1F8</accession>
    <name>A0A4Q9L1F8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0617p0020</name>
        <name evidence="1" type="ORF">CWI37_0775p0020</name>
        <name evidence="3" type="ORF">CWI38_0086p0050</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000775">
        <property type="protein sequence ID" value="TBU01209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000617">
        <property type="protein sequence ID" value="TBU01834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1F8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0617p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0775p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0050"/>
    <dbReference type="OrthoDB" id="2186267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="124" mass="14651" checksum="38BC0DBAE6BD4791" modified="2019-07-31" version="1">MIDKIMELIQLQDNLKVFEDYPPQNNLTTLSERLKNITSLSILKKELDGHFKEIMDKNDDDSIYYYESIRMLKFIDKLFKKIEEHTSQLNGDGVDDMIDVYVESLVNYVDNVDVIKEHIEFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3C4</accession>
    <name>A0A4Q9L3C4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0592p0010</name>
        <name evidence="2" type="ORF">CWI38_0023p0070</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000592">
        <property type="protein sequence ID" value="TBU01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3C4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0592p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0070"/>
    <dbReference type="OrthoDB" id="2191508at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="100" mass="12109" checksum="C297C057F1A7C32C" modified="2019-07-31" version="1">MILPPELYTRERQEYDLKDLKMYYFLIMDLNLGENINIKRSFFWLKKLVGTERFLEEVTFLRDFIYACRANRHAIDSNFKNILEKMECFKTQTGKKIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4Q9</accession>
    <name>A0A4Q9L4Q9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0625p0040</name>
        <name evidence="10" type="ORF">CWI38_0706p0030</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000625">
        <property type="protein sequence ID" value="TBU01801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000706">
        <property type="protein sequence ID" value="TBU12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4Q9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0625p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0706p0030"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="8">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU01801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="551" mass="63659" checksum="160EE43072F76563" modified="2019-07-31" version="1">MTEENFDWYEDTMEIDVEEFVPSEEKAYLTSKFFDLMIKVFNYSALFALLVGIFKYLFIRRHIEILNIEISSLVLFSVIFFGSLSIIANIIHLIAYVIKNIAEEPTEKKFKSISRWLSLSLWFLLNLYLLGFLKSEFKEYYSITKNFMLCGLLTGVTFSIATLIMEYFCESFMERSLSDKIVQVDIREKIIASMKNYRYELSDVSTTESQPCTCADVFFWNRGGNTVSESDDGHINLARRDTKKVGSLFFKSPELQSLYDSKTLARDVFLKASTNGEYLSFNDFSSMFPSTQIALQAFVFFDSNDSRDINKKEFRDTIIQFYMDRVNLEKSFGIAKGFVDIIGDIFFIIVSIFLILAWLVIFGIPLSQLAAFALSSALLLNFVASGLAVDMYYNIMFIISHPYDIGDEIILENVDYKVYRVGLTSTSVLAMNGGEIKFLNSQLWKKSIINMTRAPEKILIFNFILKPELDLETFRLFKVKMHDYLKERTHDFFENFSFQSSAESATTINALSCSLILKSKSFKTKAKKFHLRVEITRMISDFFEELGIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6J1</accession>
    <name>A0A4Q9L6J1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0522p0040</name>
        <name evidence="4" type="ORF">CWI38_0021p0140</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000522">
        <property type="protein sequence ID" value="TBU02250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0522p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0140"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445339" evidence="2">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="159" mass="17143" checksum="60F2EB5D25ACEA40" modified="2019-07-31" version="1">MNRIFIIVIGFALYAFAKLSPRQQLAAQKLRPSWLAGAKKEKAEAKKKEGKETSKLAQETGKESDKKEGKEGKGSKLAAAAEADADAEAEEIPDKKSKAKKESTKKDEGEKEKSKSKLFEMQGGPASGSFLGEDMEEAPVSKMDLLSQVPPSLAAAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7Z3</accession>
    <name>A0A4Q9L7Z3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0249p0010</name>
        <name evidence="4" type="ORF">CWI38_0142p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000249">
        <property type="protein sequence ID" value="TBU03694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000142">
        <property type="protein sequence ID" value="TBU20050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7Z3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7Z3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0249p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0142p0020"/>
    <dbReference type="OrthoDB" id="5395350at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725:SF14">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725">
        <property type="entry name" value="ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="187" mass="22344" checksum="3BB2C1BE7D0B00AC" modified="2019-07-31" version="1">MEDCYYFLYSSCSRNGSCVYRHSQVAKENPVLCKNWDNKGICFKDCPFRHSRYHLSKNRKDILCYWESQPEGCTKEFCEFRHLNLYKDSWKDVRVKSLEEIRQEKIERQNLLKNAGKNNYELSFEKLKISESMSASQPNILSQFKSETTNSLFPEENKNKFSFFDRKDTKSTENLFGYNTHENVRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L975</accession>
    <name>A0A4Q9L975_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0314p0010</name>
        <name evidence="3" type="ORF">CWI38_0041p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000314">
        <property type="protein sequence ID" value="TBU03320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000041">
        <property type="protein sequence ID" value="TBU20638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L975"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0314p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0041p0030"/>
    <dbReference type="OrthoDB" id="2194517at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="41659" checksum="4B3BBEEAA2441E97" modified="2019-07-31" version="1">MDQKPRRSLPQKISKYIQDSFANLSSFLLNKTSEEENIFYTPTNSLENTKVSKSKIEDLDQIISNSFEESLDWSKDNLLSEYTVKKTDINSDNFNQQFMPERSRNGSTDSLHEIQTDGCKETNNNSLEYLAENLTIRNDISDEINFDDLEIKDSLLSFRNGTNQRRNTQDIFSNSINVTRDQSISFLHAKVQDLELRLKDKESREEEYKRLLEDLDATISYIIEKEETHNKDVYLNIIKEKTNIIDKLNSDIDRYDYNEKKYKDHISFLERDLMNSQERSDAYRCIASEKITILETERNKLRENLDIERKKIESMCKKIDHLEKMVSIRSEEGIELVEYCKYLLKNHQKIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA99</accession>
    <name>A0A4Q9LA99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0142p0020</name>
        <name evidence="2" type="ORF">CWI38_1690p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000142">
        <property type="protein sequence ID" value="TBU04386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001690">
        <property type="protein sequence ID" value="TBU10543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0142p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1690p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="167" mass="20069" checksum="434BA5936C592748" modified="2019-07-31" version="1">MNFDFIQDFHYDLQTIAYDFYRNPVAEFLLDIPSYYNFTELNRYCSNEDKFFYFLYQELLKEISNSIIKKDFIIFSLNLYILYYIYKLYKIPIEIDINILESASEFISLYENDISRIIVTCLNSLKKDGFIVFINSYNEEFSLEDMGIIFKEISEIENFLGANIEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC90</accession>
    <name>A0A4Q9LC90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0065p0020</name>
        <name evidence="3" type="ORF">CWI38_1047p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000065">
        <property type="protein sequence ID" value="TBU04975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001047">
        <property type="protein sequence ID" value="TBU11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0065p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1047p0010"/>
    <dbReference type="OrthoDB" id="2193149at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38560" checksum="BA1611631FA5C85E" modified="2019-07-31" version="1">MKSFDIKAAIEIYSKEKRDVKTYFVKRKKEKELHTIEVDVERSFGFLKGEDKVSLARKEIFKEILFKVLKTIPVEYLQSMSEIVSVIVYYNFKDIVEEKLKQIDIAEIKSKSNKSNINLSSTSLSKDNVIWMSENESTSKMSESRLSDASTSSDNFDYDQFIDEELFKKTCVTVTNVLKEKYLPLVDDNFKMYLRYNSIFIRMMAKRNKKIYVDESLKYMNTTLTWFIRSLVSIEDILAVYGYFLCCPTSFPFLLLVKFYDKIDNKIPIERLNDNIYQELVTLEREFLEVEFEMSRPTTALGKKTGLITVGSIIAVGAAIIIYRLSKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGK9</accession>
    <name>A0A4Q9LGK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2647p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002647">
        <property type="protein sequence ID" value="TBU06080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2647p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="17487" checksum="17256156F8313C10" modified="2019-07-31" version="1" fragment="single">ANELGLIYKCGVEIIPYVMIWDGIVTKYHKSHLKRLEIPINIETYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH26</accession>
    <name>A0A4Q9LH26_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2403p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002403">
        <property type="protein sequence ID" value="TBU07418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH26"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LH26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2403p0010"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="486"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU07418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="635" mass="73819" checksum="02165BE697D49524" modified="2019-07-31" version="1">MNTSDKSISHLNRILSLTKCKNCFKYKITKMKIQCRHLLCSECDTLSCKICSKHSIGIDIHVYTFLHDLLSRNCNELNEFKIYRKKEDIWVESQEVFEENICVKNNLYKYKYESEKEGKQEFSDLKGEILNLKNMFFGEEKNAVENRKNNENETISTLAESSFAIPFTSPVSTQKSNNESKFTQFVSSDISKEKEIKNKENLCVTGFDKNMNLRDKERTLRLIKESKYDITGKKISNKNNENIDKISTNFTEILNKNNENIDKVGTNCTEIIKKEKQILNKNNQIVDIMSKNGREIIEKDKQILNKNNQIVDKLFKNGREIIEKNEKQISKNRFDSIKINKNETNPIITTEDHPNSESKILKNIKNSIEDKNIDSHKKTKHEISPKKSSKNPIISLTTKSWKNKITKNEDSTENQNNFLPNLKSEPPKNIKISLQNSPNQVIQPEIQNQTNLDAFVFLTSGLSSEENIFISKTFWSLQNKLNIPIEIKSEYSSSITHLIVNIDKNGCCLRTLKYLLCILNGVKVVSYSWYKKLIKVPSVEEKDYFIKGDNISGGNNVPYQIYKNAQNGIFYFNKINFLIQKKFITKDLRKVIKNGKGKINENNFEFTNLKVQNEKEIYNFISNGTFLNYKSDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH47</accession>
    <name>A0A4Q9LH47_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2399p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01002399">
        <property type="protein sequence ID" value="TBU07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH47"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LH47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2399p0010"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13897" checksum="BC27AD1838D4F97C" modified="2019-07-31" version="1" fragment="single">MKILAQGAEAKILLIENIIVKERIPKLYRPVELDNEIRFKRTRQEKKIVDKLYQNSILVPKIVKPLQNFDHKTTLFMEYIEGSILKDFLCQIEKYKDNFNKSEHSDSFSIKITEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHH3</accession>
    <name>A0A4Q9LHH3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2381p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002381">
        <property type="protein sequence ID" value="TBU07579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHH3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2381p0010"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="446"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU07579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="904" mass="102368" checksum="9807DCB772F71900" modified="2019-07-31" version="1" fragment="single">NPYITNNNTTFVLVAPFKALIHQHYKFFSKICNKIGVRVIEITTDSDINNTNIFNSYNYNKTHRNNNTFYSNSSSNSNPFISSNTCIKRNNNIKEVDQCINRTDKDYIADREGFSNREYITNPNPNKCINTFNTNTSSNSNPTPNKCINTFNTNTRSNPTPNPNKCINNTNPYTNPTSNPNKCINTSTLIITTPEKLEILTRNKNIFYNLLLIDEIHIISSKRGVYLESIISRLIYNGISRIVGVSATVSNWKDFCNFLRVEKKDCYVYDERYRPIKIGYEFVETKGVNNSIDDYRGVSDKSSNIKGVSDKSSNIKGVSGKSSNIKGVGDSIDDYKGVNTSTNKQQGVNKIPYKQHPFNTNNTLLNNILIEITLKHINCNSILIFTHSRKDTYDTALYIINNKILNNILNKEDRSKTVNRALLMFNVEEEVSNYRGVNNSTSNYKGLNNSIGNYHPINNTINYHPLNHSTNSNISHLSINCIIPLLYIGIGIHHGGLQSNVRNLIEYLFKKGVISILVSTSTLAWGVNLPAWCVIIKGCLYKNSKELSDVEVMQMFGRCGRTGYDKSDSNNNYSNDISSKTNNNKNEPNPRLTLNGCINSNTVNNNTHSNPNPRLTLNGCINSNTVNNNTINTSTTNNIPTAILISNTNIYKYISLITNTLPLISYLNTYFIDFFNSLIFTGVNTYNQLLLHLKNTFYYFTTYKKGVNYNSIVEEGVRILIELKYVKQCYNYKGEDIERVGGVNNSIDYYKGVNNKDSNYKGVNNLSNKQQGVDNKDSNYKGVNNLSNIHHPFNNSTTHHPLNNNTINNTVLFPLDKCVLSCKYFISVNDFNILYNNLEIGVLEENIVIYILSRLSLFNEEDSLDDNSYSSNNRVTTNNSNNSYISNPINYPSINTSINTSVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI52</accession>
    <name>A0A4Q9LI52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2395p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002395">
        <property type="protein sequence ID" value="TBU07466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2395p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="310" mass="35598" checksum="385A4921CF9E30E2" modified="2019-07-31" version="1" fragment="single">MQNSEQHLLENSLPSSYTRITHPPASQTCINMQNSGFASLSSSNTPLPSSVEVSACERSYNMTNPCPLAIPEGNRLRALRTIFVSVTADPKDGWTELNGKKVKFEENGERRRIANCLTDTCILTYTTEYINLRDKLLSRIKQISKKIGKVVVRTRKLTRKLVDSKVWISLIDYLPVSIMEAAYIMQAAQVCYNEATRKEKPRFAQKENIESKISKLVLSKDLLEKNRKQEKLSTSDTKSLRKILRECNLNLSSVTDLSKAEIKRMSRFYGELTERVESEHMVIRNERVSFWSIMRNKNDDTVTYNDYLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJP1</accession>
    <name>A0A4Q9LJP1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_2420p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PITK01002420">
        <property type="protein sequence ID" value="TBU07300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJP1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2420p0010"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU07300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="31691" checksum="3A69C13C02F67C03" modified="2019-07-31" version="1" fragment="single">MFRMNDFELIKTTGTGTFGRVYLARLKRIYTTSDKFFAIKMMRKSDIIRLRQVEHVYNEKILLSYMRTSPFIVKLYSTFHYNNMLCMVLEYVPGGELFYWLKKMGSFGIYATRFYTCEVLLALQDLHLRNIIYRDLKPENILLTASGHIKLTDFGFSKSIDTLTYTVCGTPEYMAPEKLLGEGHSKEVDYWSLGILIHEMLTGNPPFYNESHYIIYQRILNENINLSSCIDKLAGNLIERLVERNVSKRLGSCNGVSEIMEHPFFYGVDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK37</accession>
    <name>A0A4Q9LK37_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2249p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002249">
        <property type="protein sequence ID" value="TBU08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2249p0010"/>
    <dbReference type="OrthoDB" id="5549358at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="502" mass="59656" checksum="38C174B995BE6F1D" modified="2019-07-31" version="1" fragment="single">TVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEIDEIGDDCFHPCRDNYYFLSTNTCSLEKNGKLESCQTLSPKNYIKNFKIRYPSDTFFSSVFFDERILENQAEVKIYMNKHDFSTFMYLIEILKTEGNIFRQIKPQMVFEILKHLNIFRVKRDEKYELFIKTMVYYSMITDATFARVASSLILNFKDYNNFHVCDLIAFFLKSYFVSKTLIYELFTEYDPMEYTNALYLHKKYKTYDEICFVMFRTCNLHKYLKKAASRCIWRNLIRVFFVDKVHVGFSDKRNMSEVDEMVALLPPHFKKITVAITKETLTILYKLHKCGFLNSKETVKVIFVDSISYEDFMKVISYFRNIEKLTLEFLKVYPDVIHYPNEEFKIAKSIKFIKIRIYRLFLEEIRMESVIQLFTRPNTIFIDLYQDIESLDSKTNLENFLTRNLKNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLZ3</accession>
    <name>A0A4Q9LLZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2163p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002163">
        <property type="protein sequence ID" value="TBU09294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2163p0020"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="17568" checksum="D8261CC0BBA8EA72" modified="2019-07-31" version="1" fragment="single">NELGLIYKCNIEIIPYEMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVKTISFDRRRGLESGPNAEESWERALLSVILGAEMHKQPIPPLKQVDNKEDDVKTENTKNILPLILDGITTAKEPITNTNEELEFEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM55</accession>
    <name>A0A4Q9LM55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2198p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002198">
        <property type="protein sequence ID" value="TBU08986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2198p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020286932" evidence="1">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41247" checksum="8A7F76F6F934CE49" modified="2019-07-31" version="1" fragment="single">MIITTFKNIFLNYLICYLNVVWLSDLDANCYLKQDNCTFAADNCIGKNYDKVSDLYTQPIPIGDPSRYFPSITLSNRFHPYNLPQKSQEKSIDITKHISHNDQFNPQKLPSCLYSSYISSQNISIDDDLPRFDLAFCHLIESNQSALQNKDVPNLESTAQSNILLHQEKQFLFAQQYQLLPENSDKSNTKESESCVSDLKTPNALSSLINFHDEFDYKGTISYLEFLKKITLHNATPKSYEEQYDLKRAKKRLNLLLSRQERYVATADNKSLLSKCEEGDKLNMICNKYHNYTREYSMTRWKKIGIHIFRRLKSIQKEYDSILKSFIKLEEFVINSKEKNANDIVLNNIAKMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPI0</accession>
    <name>A0A4Q9LPI0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1846p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001846">
        <property type="protein sequence ID" value="TBU10329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1846p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26939" checksum="336DC916A7AFE474" modified="2019-07-31" version="1">MKDSNVLGFCYSCSQIEKMIAVIIFFDKISQKNNAKEDKLQFYVIKKHADKIKDTNLVIPPYIFSLKKLKEFKDKYNSGVLTRFGLHLTLNTSEINVINKLVTLSEELASEIEVFSFLNANLQDKSIQISTAGDNLKNGTKNDLNLFQSSTNISLKRKVPSDFLVFILHKANVFDKNNIYDSFLKSIIADDSLREILLACISDIYMYFVKFEKYSFYYNYKIEVFLRKLKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN5</accession>
    <name>A0A4Q9LPN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1979p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001979">
        <property type="protein sequence ID" value="TBU10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1979p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="7688" checksum="CCA93A34C12A39C5" modified="2019-07-31" version="1">MCYYRGSKGNILKIVRVIHIGDSEGNLYKGSKGNVLKVGDSKGNVLKELGINNSNSNNSSISNGNSVVIKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU1</accession>
    <name>A0A4Q9LPU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1746p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001746">
        <property type="protein sequence ID" value="TBU10458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1746p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="323" mass="37824" checksum="BEAC1742844EA1CC" modified="2019-07-31" version="1">MYEDLLEKNKDECNCEKQKKHTKADDNRPKQKEEAKDKDKPQEEEEEAEVKEEEAVSECNCDEDNDYLNELEAERKKKNAVLKAKQLEDRKKVEKNVIPSIKAESAINDKLMRDAYERRLRDYERAFVDRLGCEVLMRKGSGLELRGCYCGASIFPRTELGKGLNSIEEYKAVMWKSSISLYSRIECIQSRKYKFNTAISLVKYLEKRSNIFILDKIIKNKMLSDVVITSQDSLQKVEIEKFRKYDLLAKELGIFYVCSIVIILLCDNLEQAPNTNEYEVYIQSILLRSNCFEKENTIYSLPPMSYDIDTIKKRIINIYKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQB5</accession>
    <name>A0A4Q9LQB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1038p0010</name>
        <name evidence="2" type="ORF">CWI38_1635p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001635">
        <property type="protein sequence ID" value="TBU10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001038">
        <property type="protein sequence ID" value="TBU11790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1038p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1635p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="11768" checksum="5FC500CC7DDCA533" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNADESWERASMGVIIRAKMHEEPIPSLKEAKREEDAPLISQGGTTLEEPINNINEESNLEDETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQI4</accession>
    <name>A0A4Q9LQI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1570p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001570">
        <property type="protein sequence ID" value="TBU10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1570p0010"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="366"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1109" mass="127418" checksum="19CD97CC0933A5D4" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANDAYEVKKCDSGIQKPKHALTCKIVLDTLPSPNTPLPSSVEVSSCEPSYDMTNPCTLAIPEGNRLMALRTIFYSLHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLKDKFLSKIKEISMNEIGKVVSITEATYIMQAAQICYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSISETKSPLVKKNESLNVYEKKITMYESRKQFRKENRMFELFRGLFYRGLSERVESEYVFLVYNVEQNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVEVICLKGTTQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLAENQLGAVRGVQGAKEQALLNIALNKENGNNLKATVIDVKKAYDSIDHAYLTQFIENHNLSDLIMKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGECLSPLLFVLRMDPLSRKLNEKYTKVTVQTDTESHFTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDTRGIPTRSLFEEEQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVRRLEPADFSKLDDVVRAVLVKNKIHLRSRCKERLYLPRTKLGRGLNSVELRSGHILLQFLDCLEKSKDISTRRAAILKVENNNKTYLALIKGFLKIKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHIKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVNVFWGADGMCQHCGKSGKTVDHLATRCKKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVSIRNNRPDMFILDKKKNKITLIEVGITSQDSLQIVENEKLRKYDLLANEFGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLEKTVETISSPRLNAEESWERASMGTNTPFKKREEIKNGAKNNTSLISEGETTLEEPTININEELDLEEEKTLVKEVEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX8</accession>
    <name>A0A4Q9LQX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1551p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001551">
        <property type="protein sequence ID" value="TBU10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1551p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="10259" checksum="26D0F57F4DF3341F" modified="2019-07-31" version="1">MNQIFAKSRIDMCLEDDPLCENSQTGTIPSDRLRISEQKINDEEIMEREQMGQLTFPLKQQKTLIEDLTKLNTRGLVLEEECLKFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR00</accession>
    <name>A0A4Q9LR00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit delta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1466p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001466">
        <property type="protein sequence ID" value="TBU10939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR00"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1466p0020"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="792" mass="86335" checksum="308638EC7CE2D22F" modified="2019-07-31" version="1">MHTKQSSRTSKILTSNIQAASSLSSYLSTSLGPSSHTKLISTTPPTITNDGATILKSLKFKHPIFPLLTNLSTSQDSNCGDGTTSIVVLTGYILDVLYPLTTDVHPTYISSAIQLAIQYVQHTIHTHSIHISTDPHTTTLLHSRSKIEVDNSKEGGSMEGKLDSYKDSNKDSNKDSYKDNNIRDKIRDNNIRDKIRDNNKDSNKDSYKDNNIRDNNNNTTTNKYTNNKYTNNNTTKDNTTTYFSLGNKILVNAINTSLSSKITPSSILTPIAINSIIKTKGNIKNINIIKKEGGTFEDIKMYDSLILKYKVTRGEGGMLEGGMLEGGMLEGGSNSSKDSSKDSSKSSKDSIINSKDSSKSSKDSIINSKDSNKDSSNTNNQHNNTSTNNQHTTHNNQHTTTHNNNNIIRSLAVITFPLSLPKPYTDSKVSITTSNLMDTLIKEEHLYLKNICNKILEKGVNIIIIQKSILKESINDICKFYMERKGCWVVSDVERQDIERICMCLGVEGVSDVEYIEGNVREVEVEVCEGYIRIGGCGGVCGRDGVCGGEGVCGSKGGSSISSSKDIRDNSSISSSKDTRDSTRDSSIEDTNNTPIHSSNTNNTTNNTTTNNNTTTNNNICSILLTGGKDVLEECHRNIIDALSVSKCLYDLPFVVFGGGWIEEVIGEVLIKEGNNIGGSKGLCLVEISKAFKRIVLSIRSSGDIVFMPVKVCMGYICMALECAGGSVIGVVVLVLEGCSVIGMEGVSNRLKGVNMRIDDILPGRRVLVIGGSNKCIMGVNMKVWCIMGVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI7</accession>
    <name>A0A4Q9LRI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1426p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001426">
        <property type="protein sequence ID" value="TBU11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1426p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="683" mass="81600" checksum="B281DFCB655D67A1" modified="2019-07-31" version="1" fragment="single">MCNTHLRKTYRNRKVGFWSFFIFVTFRIIFTQRTIAMNFFENVESVSEKNEPSNCIYSDICFDFLRVKPKTFNVDSKIKILRTFIIDLDNFFLKFINEEKIEENQHNNIYINTRLLKYDDFEYFYKLVVGFPVFIDKMNEGNYLKIFGIIDIFKFKKNNSLKEFKRILWISIVFNPKFFEKRDYASTMANKNIFSSFISKISIVELLRLYRIGEATLNKIDDNSLVKTLLDDFNFDFINPNKDYLYLDTDIISEIQKNCTKEVEFLRHIAYFFRIHTFKRIFFNKIFCTAKHNYFFNFSLFEGTNEIFLLRCLNVDVLIQVLRIHSLRNIKTINILNCNFTTQNIISWSKTFYFERLNFINGKDKFKSYHYDSDLNPSLRNIISKFSETMYIENKSNFFVVDKRQIILESYYDESKIEELSSLEGLHKMFIPMKLSDLFLAFNFYSMNFKEFKNIEISFTNMHIKDFNLRESEILNNILSMRIVNSTVNSIFLSKILLFPSLKTLIFYISRICYQKDEAIFNENKKIESLYFRNSVIEDHICFSNFLNSLECLRTLEIISLTKNTNPFISNPYNIKMNLYSLLSLKYSSNYNCGNDIPFFQIFPNIIEFELGLCYPNGTIHKIFFDKNFDSLIKLTFDGVKIGKKDKDALKKCTNIHVLRFTRTCKISEILFAELFNTNNMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ6</accession>
    <name>A0A4Q9LRJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1601p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001601">
        <property type="protein sequence ID" value="TBU10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1601p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="20937" checksum="D7E9FEE4730F6B29" modified="2019-07-31" version="1">MESFFVFLNSITGFEFMKRERILNMSEFIAILGLFDFFIPKKNTDYSYVVFSLLKDGISNSLNRDEIENLAIKFRSLFNIEFCLHLLLRLFEKLSLQAISKKNYITLYTNGIEIHTHRKSNINYSESYHLSLDAHVMNSIMSGLNNQYLRNLFDLIFSINNINSLRLFRNYKCILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL4</accession>
    <name>A0A4Q9LRL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2014p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002014">
        <property type="protein sequence ID" value="TBU10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2014p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6705" checksum="D5155EE3E7730086" modified="2019-07-31" version="1">MEDGVKHFQTKNSIITILNAETRLKNPTININKKLDLEEEMMVVKEVKENNKSGIETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW4</accession>
    <name>A0A4Q9LRW4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0615p0010</name>
        <name evidence="13" type="ORF">CWI38_1337p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="PITJ01000615">
        <property type="protein sequence ID" value="TBU01846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001337">
        <property type="protein sequence ID" value="TBU11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0615p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1337p0010"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="111"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU01846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="308" mass="36734" checksum="729DF210A653CA67" modified="2019-07-31" version="1">MGWREVKQDAIGFIAYAIYPVIIIYSYFVVVGIFCLEDKRFENAYIIMTFIIYHFLALYTGIFYMRLLSNDEVSTLSLFPHMRRSESENIIDDINPFFIQEISKKRLRDIQTCNICKTYKPPRAHHCKKCKKCFLKMDHHCYLVDSCIAFHNYKFFYLFLVFNSIFMLYVILTLVFPIFMDDYTSSTTNYIIIVLLFSIGWIITMFFLVLHTKLISFNETTIEYETLEEYLAKEPFNPGVFQEGPLVTYDDVTIHDRRILNPYFLGFKENWYQVFGKDPRYWFVPTFSSIGEGISFQKNCKDTNFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS13</accession>
    <name>A0A4Q9LS13_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0837p0030</name>
        <name evidence="9" type="ORF">CWI38_1258p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000837">
        <property type="protein sequence ID" value="TBU00995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001258">
        <property type="protein sequence ID" value="TBU11343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS13"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0837p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1258p0020"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU00995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="166" mass="20052" checksum="10250573D1108474" modified="2019-07-31" version="1">MNIAILKTYFDRIVPMKRERWTFFGIVLFLFVLRIAIKRTHYLITYCLAIYLLHGLIGFCTPKEENIPDPFDNFEDDVYIPQTIDDDFKPFMRRLPEYSFWLMSIRLVMLALMGTFFGFLDIPVYAPILVVYFIVISFLTARNLHRHMKKYKYDPFRSFKEVYNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS29</accession>
    <name>A0A4Q9LS29_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1299p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001299">
        <property type="protein sequence ID" value="TBU11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS29"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1299p0010"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="14252" checksum="A33969B86F0226BB" modified="2019-07-31" version="1">MIWTKIKKNIFIKKLQNDGYTISDGIKYGVDILVYTGNIDEYHAKYAILFFDEQCIKDIVSVQRICSSVGKILVLVDESFNFYEKEIENKEMREINYNLIIKQENKNLEIFKKKEIENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS79</accession>
    <name>A0A4Q9LS79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1270p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001270">
        <property type="protein sequence ID" value="TBU11314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1270p0010"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020527356" evidence="6">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="444" mass="52476" checksum="D056E4882C2BA700" modified="2019-07-31" version="1">MKNISFIILIYKFLNVWSSCFLEKNNNTTAVSDAINIGNFCETENEKADTMPDIITLETDGDEGSSANVYKGKNFQKNETFALKLYPKDDKNGFENEKEIYKLLKSEYIPKIYGTARYAEKYKVLILEYFECTLYDYFKKNLVKNLEMFVIIKHILFGLRLLHDNEIIHNDLKSNNIFIVEDLQIKIIDFGLSCTENNLYFIFEDYNPKEINQYTYISPEVRNSISYTTKADIWSLGSLIKDIVSYLCPKYFSKVDLEYITKIICACHSNDFMQRPSAKSLSYCSIFDIMYPFLDILKNESIEKLIFSSFMFFIKDKNKITFCFNLRRIYLYCIKSSSNQHTIDQKLFGYLDDHKFLKSVFKDKHIFLSQYRFFFISIDDSNLFSVMDLDYRTLIMVEEFCKNFALLLESPISTVNLFQGIYQNIQKLEENKIFKILKKELEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL5</accession>
    <name>A0A4Q9LSL5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1689p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001689">
        <property type="protein sequence ID" value="TBU10545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LSL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1689p0010"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="97"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="392"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="647"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="875"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1792" mass="205930" checksum="1A0CAAC8A2646F78" modified="2019-07-31" version="1" fragment="single">GVSNSKGMLEGVSNSKGMLEGVSNSKGMLEGVSNSKGMLEGVSNSKGMLEGVSNSKGMLEGVSNKGYTSNSSVSASRNYNNTLPTITNNTLPTINNTTNNTLIGCDYIRAWMGDFSLIKNVGKYCIRLGQSLSTTIETVKIENDNYREESDIIRNVGVVGRDICVGGSIYSNIYSNIDNSKDNNRDSNIGSNIDNTDTNTPTTTNTPTTTNNTLYCFTDGCGKISYSLSVKVSKILGLNYIPSAFQIRFKGYKGVVVLDKELDKIENKYVKESITEIMYGSGSGSGSGSSSGKVDTDILDSSKVDSNITDNILDSSKEDTNIIDSNILDNTILDNNILDNNILDTNLIDNNTNNILDNILDNILDNILDNNNQNTNTMIDPLAFLGLHSKVDLVLRPSMRKFESDYSFLEIINYSQCIGCYLNRQIIIILESLGVEKRVFMEILDESLKVIFRNVFREPFLILEKKCNFFGVFKEFKREFGENKMGFNGIDEMDGIDGNNKNNEYNEFRNEGRGDNRKVCRTDSKKVCRTDSKNEFKNEIFFRKLLFPIVGSVFGDLYRKSRLYLDKGRVLIGVVDCSGVLEENEIFVMTSRECSGDIYNIVRNDRFDRFDRFDRFDKGCDNNRSDTSNTQNTNTTNQSTNTTNNQNTGDDDFFVVSSTCIVTKNPCLHPGDIRVVKAVDRKELYHLKNCLVFSSKGRRPVFNMCSGSDLDGDLYFVCWDERLIIKKMYEPDLYKNENVLIKEVVSSTDIVNFYIKYMRENQLGRIANAHLALSDMSSKGVLDEKCLKLSCIFNQGVDFPKTGYVAKLPINLVPEAFPDFMEVNGSSYCSRKVLGVMYRRCGVLRLDQDINLGSSVNTSQYNRVGDGMDEEDGMDCEDRVDGLDGGNNSKSSSAYNSNGKSSSAYNSNSKSNSSFNFTPNNTSDLIYCDCNSCLTDITDSAFDYTRILIVGLNMKRKVVVYPVGIERYMEQAIVDFNNYKFEIYKLMRQFNLKRESELFVMSERDEKTGYEEQRVQRNVIVGCVRELFLRYKKIFYKDLRKEEIQYKILSWYKICDNCKEDVHSFPWILSNLLMNVLNKYLVMREYSFSRVKIYKDGKEIFLSNKYWLKRLELFDVRYSRFCLNERVVFVESGYKLRDVFGSKMTNLYYVREDKNYDRNGGNNRGGDKFGEEIFLDEKKEKDEFMEGINNNFSIFVSGYIERNENMRRVLSLCDSGYLELFHIFFALKIFSFDKFGLIFDFFEYLIANNIFKIEDISDFLVDMSSFSYKKAEESVFLSKHEMFIKWYIKNLSNERFENRRNKKGGDFGKNNEKMNGECGGVEDFLFLEDKSNVILIAAYLISLNINITYKIRMAQNILAQIKVSIRNNSVISSVDTFIGIAKHNDLSIVGMLDKYDDVRLKKYFGKKNKKHEKYSLFVPVLMNKGICEIECYKNDFKMFLLSHYWNKRYDCRNEELEVRVTTGKLYFYAVGSKYINMPVKIKELVNLIVFNRSKFGSNEIDANKEYLNGFFINDHVLLDRNERNGYVEKKGLVFRGKRVECDLSFRINDVRYGIIFEFIQKSNEFGEVLCDVEKRVDGFKDDFNINGNEIHNEDGLKPFNVNMFEERNANENNSSNLTLLEKLQNKSEYRIITKKITKNRNIYGRYEIINSIGPNDKDILFEIAREEILYDKDRNINNLSESESFLLREDGLEYLRGDFVVCGAWKSYRNLRLDISTIIELSLSDSSSKNLKIPLILCYKRILSGMVNGNFTAEKKCSVVYGLALKKISEIMNHNQFEDYFNGVWGLYTDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT01</accession>
    <name>A0A4Q9LT01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1125p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001125">
        <property type="protein sequence ID" value="TBU11594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1125p0050"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="17454" checksum="3291991B3AC634C5" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLSSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHMYYNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT33</accession>
    <name>A0A4Q9LT33_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1049p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001049">
        <property type="protein sequence ID" value="TBU11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1049p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="74952" checksum="7B50F84C76502BBF" modified="2019-07-31" version="1">MLLTLKYLKALESKHIGTVLKGLLFKMYFGEQICFLKYKESFRQIFFAEIEYFIIKKLIQAFLDILMVNHTFHSHNLILLKNSNEIFDITLFNEHIPYNNLLVNDCKILYILEKAFKNLYIFKIFQILLHQLHIKSLIINNFIGYETNNKTYYFSIFSKEIFKSIIISNLYGSLNAILYQLDTAFDENLEFFSLKNINVDCYYLDFFLKKRNLKGLILNDISMDADLYNFQAFVHLIKMLEYVEFCNIKMSYTWWVDFVGASNIKRIILSFVSSFLADFFLKEFTKVISYSNVQYLEIWFSNSKLYLNFWNCLGYFRSLQTLKLINYISDMNIELNLFKVIHNMQKLENLTIEHDDYSDYFYNFLFKRHGLKVLNVRNFSSNRKIIKLNLLNNSKFLTQLILSYIKITESSLLEIFKLEFLKVLYLQFCQITLTKNSESHIAWPKNIISLYFKTYKPNLCNNIDILSGLDYLENLYLYGCQSLFGSLIDLSLMCNLNLKTLSYKSDTIYMKDLRRIKYLEGLEELNLSKCRFFGVKFYDLGDDCKFINSLKMLKLFATKICPKDLLYIRNFKNLNYIKLSNFGFTVILEKSSLISLTRSHIISKKRYEEFKDGNILRNFYNEIIGSHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY4</accession>
    <name>A0A4Q9LUY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0739p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000739">
        <property type="protein sequence ID" value="TBU12478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0739p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="20765" checksum="B0C4B89B3EB12DED" modified="2019-07-31" version="1">MKEKTKILGFILGIRDKYFRCMIEQKFSLLLENLSQIKFETKNDSQSEKNHKEINSLGVASKNKKKFKRSDMKVQVEECIECDPLLTESIDIFARILTDLEFILLIFCFDGFFEQVFQYLNIDFGKVNRTCLCESESNWVTGFFNKKSIFNILKGAEKKIHGASNGSNCIDLLNEECEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE7</accession>
    <name>A0A4Q9LVE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA excision repair protein ERCC-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0073p0050</name>
        <name evidence="8" type="ORF">CWI38_1130p0020</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001130">
        <property type="protein sequence ID" value="TBU11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000073">
        <property type="protein sequence ID" value="TBU20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0073p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1130p0020"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="21994" checksum="290A19C0815E0E97" modified="2019-07-31" version="1">MITVNTNQKGNNILNFLSKSTFCFGENIKTDYETANASIIFLSLKFHCVKPEYIYKRIKTSTKNRKILLLHADTVNYELKIEELFQIADTNNFILIIAFSNEECARYIQAFDINEKRSLDILRKKETNQKEIYETFLCCFPKINKTDASKIIGLDVNLNIFFNSKIENILGKNKSENIKNYLEMEFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ7</accession>
    <name>A0A4Q9LVQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1056p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001056">
        <property type="protein sequence ID" value="TBU11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1056p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="602" mass="71357" checksum="E4D0E6D0D6070699" modified="2019-07-31" version="1">MGLFNNSLMGQYSNEYRKFNYKKFYFGDKLKPVITNLVFTCFLQVYLLGLKDLNIFYFFDQDNNASINNDLFANLVLQFKNKNLASILKYWVEKKSFHFIEHYIARIYIKRIEIGKLTSDISDDRLLIFIEYFLLKIKEIELIIDENNVKILELIKCKRIMLLKTKILSISNINIKDIFILLQFPKLEHIFLKVEVNSDKNHMVFDGRNTSQLRFFKDIFLFSNQKIIDKIFEIFVELLKCKDLKVIIRKEIGLFEAKILGAINFIDSNLEYKKGNHLFDLTDTNIYSKIISLDTIMIKYWNPRYKSFINIFDYQEIQNLNVFRSQLCVFLYTEIISLFKHPKIKKIILNDCTILKYTDKIKTEDFENYALETLKTQNTGFSKHFITLLSGFLNLKTLSLDSFIKKTEDINILKDIKFPKTLGTLDLKNNNFEVLNERVRFQCQNLKIINLSNTDIPKDSLFYLISFKDSIESFYYSHNRIHSSDFNLFCQMTNLSCLFLSHSTFKNITFSDLIVQKHLTTIKVLNLSHTTLYPQDLFKISLIQTLEHLNLFSCRFKNHSKFFFEPNKLPKLIYLNIEINNFTDSEIQSLKETTNQNVLHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW31</accession>
    <name>A0A4Q9LW31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0742p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000742">
        <property type="protein sequence ID" value="TBU12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0742p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="54372" checksum="BF001468A7CDD2DD" modified="2019-07-31" version="1">MLKSIIISNFNTSSIYFVDKLFKVLDQNIDYLSLKNTVVNKNVLDDLFERLKLKGLVLFGNCLLEGPDPVENYLYFNKTLEYLNLKVLNACFSWLLNVFETKNLRKLILTFLTSNAQKNFMKEFCKVNKNTNILHIEICFFDELFYSFCDSLSYFKSLQTLIISRFKTDGNTESCLIKAIKSMKNLEHIEILHHGVSEKFYNFLLQKRGIKNIVLKNFIYSPNTLKFDSLNNNVSISEFFLNNVKITEDSLIEICKCGTLTKLKLNVCNLEPSLVSSQYSLLLKNIVSLYLEDSNLAIIKNMNILTQLNCLETLYISKCGFSCGYLAKLSSSCNLKLKSLSYISGILDANDLDRIKKMEVLRELNLSGSKFKKCGFYSLGHSNKFLGFLKDLNLNFVKIDLEDLKLIREFRELERLTLTFSNVNMYTENGFVVSHNLYRIASKNINDMSNYYKLRCYLREEVAGIYFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW98</accession>
    <name>A0A4Q9LW98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit beta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0561p0070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW98"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0070"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="510" mass="56153" checksum="2D8452AB91DBFBBC" modified="2019-07-31" version="1">MNIYTHNNLGTSEERSEEAQKTIIGGVDLLIEILRSALGPKGALKLLTGTSPIISNDGATILKNLLIDSPSAQILIDASVSQDWEEGDGTTSVALLAALLIKEVQNIGLHPCTIIKGYHIALTQCIEHLKNLIFEMTSDSIQNLAETTLCSKILKPHKKHFANICVSAISRIKKYGCDLNLINIIKIPGTLEDSYIDDGFILKKDIKVPFLKNPKILVGNTSLDSDKVKINAAKFQVQSIKELVDLENEEKIKMKKKVEKICSNGVDCFINRQIIYDFPLQLFSRNNVTVIEHADFDGVERLVKFVGGKIMSTFDSLNEDCYGSCKEIRNIVVDNERMIKFFVGNEGDGPCTIVLKGGSKEMLDEAERSIHDVLCVLKGIYEVGGVVCGGGAIEMSLALMLNDLAIKTAGKESEAILAFMRALIQIPFILAENAGFDANNIKSILRKSHSEGKTTYGIDMDEGVCCMKEKGVVESLRVKRRVLVSACEVAQMIIKCDGVVKCKPRERTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN7</accession>
    <name>A0A4Q9LWN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0830p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000830">
        <property type="protein sequence ID" value="TBU12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0830p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="755" mass="89277" checksum="E507CF42AC0D5CEA" modified="2019-07-31" version="1">MIQKKIFSEILIFINLLEVEKPAFNDFISYVSNEESNRYGCFSNFNKRKRKGVFLKGLCKETRKIVRKRISVHHLNPLNLKTNEFGTEVKQEIQIYLPHITASDFDLFCKMLQFYCDPLDYLPLETFFKFLNILSCLNLVLDKNLDKILLNLLISVRFPLENDIYELKPTILQYIETYTISSDIVTTMGKLFKNLSLFKIGFELILFLNTTNEKMYHYYNVKFETKSAILISKNLKKIFSNQNFKNTLIFKVIFIVFLKMNFKTAIFHTIPSKNTELRHFLSQILDSVDKVIFYKLSIDKNLISFLNKENCFNNLTTVYFFLPELQSNILSFINYLLNISEIFIEFDECFEESEYKKTNMNYQVVIKVVRYRLNRLVILENFEFLDIKNYILNSVFEIKSINDFEEQFRFLNKIVELNNVRVFLYGIIPLATINIIETYIWCTSINLILDFKNEIYSLQIIPFANVKTLKIRNTVINTGFIGCILNIPALENLYLFDCSITEYNETVSYPKNDSITSLNLYGKEMIGIGFIYKFLSSMINLENLALFNDNLSVLLDSDQKCKFSPKIQLKVLEFCCIFKNSKCDCFFYFPFFVNQEISFEQGFPPGTLKKIFSIPENTNIKKLSYLDNYLDYSDIGALENLKLLENIEWTGNNSKIRFYMLFNITKTYNIKFLDLNEVEFVRKDIKFICSLKSLEILNLTMCSFKKKCYRMIRRNKLKTLKCFYFENFFSTKNKKIKMHLQEEFPSSILSISLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS1</accession>
    <name>A0A4Q9LWS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0867p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000867">
        <property type="protein sequence ID" value="TBU12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0867p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25964" checksum="34139BE4D1835D2D" modified="2019-07-31" version="1" fragment="single">MHKRINNIIKKILRLKYKEYKEYIKYLDYIEYIEYKDYKEYIEYIEYIEYKEYIECIYYIDYIEYKDYKEYEEYIDYIEYIEYIEYKDSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU6</accession>
    <name>A0A4Q9LWU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0515p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000515">
        <property type="protein sequence ID" value="TBU13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0515p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="5896" checksum="2AF11DF232849D5D" modified="2019-07-31" version="1">MGVSDMVLVTSLFNIGGVSYIHLMYGVSDRGIDIVLLYNRVLITLLFYKRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX9</accession>
    <name>A0A4Q9LWX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0838p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000838">
        <property type="protein sequence ID" value="TBU12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0838p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="36813" checksum="F6221088D83FACAA" modified="2019-07-31" version="1">MQEDRIAAKNILQNKKYIPHTKRISYLSTLLPTHTTQPKKISFTYNTSLSLLQNINLNNTPSSNNLELKKFRVFLIKNLKNLKNLKKKSNIFLTIINSINNTTLPIKNDLFSWSPGKDYCDSYEFLLSLIKRNSFTQKYQKYFSKKAIITRNTTCKVINCLKLKAPITILPNIEIINKDTEIFSKYETTYTTSLPTENYTTPNLSLTDTYISSASPTSNISLNSSFSSINLHMSNFTVHKRVISHSYWCDKIHTTSSTTPIFSFLTPFKSSNKIFFLSTCLTFIEIEITGKRTVTAIVSLNKFITLIQGKEEEWLKTIGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY4</accession>
    <name>A0A4Q9LWY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0480p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000480">
        <property type="protein sequence ID" value="TBU13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0480p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="180"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="38726" checksum="CB8B4721884BAF41" modified="2019-07-31" version="1">MLPMLLDFKNLETLDLGNFEIPLNSLEQLYQTNLSETIKTLKIYHYTFASGEYQIFNIIRNLKSLHLRNCSLFSKFELILGTFSAEKIIECIHIENSDIGEDDIKYISTLRIQYLILINTKNNLSKIYYNLCNEVIRQSLWPDIVNKRGGDKRSKLTLGIKESLQTYVDLVFESWRLITMTKTFSFKKKGKSAYLSVTAARSRNISVVATMNRYGMIYHKIREKAANGKDIKLSIKEINQSCQRQGILTPIFVMENARIHHFRELNDDEEIASYLIKYLPLYSPFLNQFENVFSFWKNEVIRDGASTEPQLTILICEKFNEITREHCNFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ0</accession>
    <name>A0A4Q9LWZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0859p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000859">
        <property type="protein sequence ID" value="TBU12190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0859p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="23530" checksum="23ABF9A59FB04530" modified="2019-07-31" version="1">MMFLIYNSQVKDLADKEYEIINLLSDISEDFVEKIFHKFVYLCFPSLNYKFLEENKKVDEVKNLILSFISKKFIEIHNNSKNIFTTIKYIFKNFYFKFWTFYLQNREEFQRFLCNPEEKNESEKTCEEKNSIAADKLREKLCEYLLNNKENMCDLLKKVLGGYVSFDEDKNLGIYEEFDNILNIFFHQTGLFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB4</accession>
    <name>A0A4Q9LXB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0435p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000435">
        <property type="protein sequence ID" value="TBU13423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0435p0020"/>
    <dbReference type="OrthoDB" id="2194678at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12236" checksum="5D659378E37B4346" modified="2019-07-31" version="1">MRLTLLHARKNSSLTIELKTNYATILREFEVDNEDKKFVFSNEDRFAAVTRSTRGLNMKDQSAYLSGSIYYDIHDRALNKENSNCSLRISMKVRVFDDDEEIASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI7</accession>
    <name>A0A4Q9LXI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0416p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000416">
        <property type="protein sequence ID" value="TBU13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0416p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8706" checksum="B2A532A7555FEF89" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPECIECENDNVLKCLVETSGSHDENLPLTTIQTPRKQMVYINDRERIIEKTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ8</accession>
    <name>A0A4Q9LXJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0544p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000544">
        <property type="protein sequence ID" value="TBU13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0544p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="348" mass="42005" checksum="756BAE6AEC72045E" modified="2019-07-31" version="1">MKAKCPSQINRDKMNKKPEKYLTEKMFIRDKVRKYYTCIIESIDIIGLNFELFENFNDLESNIEIFLYHNCHYEYDECFNIVYITLKKFNLEKKFKKDTILETNTKKIINKDLEITSSFLKYILSINGLEHLKIKDSEIFIEKDICIKNNSIKYFRFSPKNSDNLHCFYELINMMQGLKEINFESTESITFRRSINRFFYITELILCYINKMIQLLKLSEYDENFDFKTTDNDISASKCPSESLKLLFVKYNLSSIKKLCLCFFSISKCDQEALRNLINLRELKMYKIDLQNIFFSELFCTSLEYKIKRLRFVRTNIFERDLTFIANLKKLKELYFKKVIFFRRLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP2</accession>
    <name>A0A4Q9LXP2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0394p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000394">
        <property type="protein sequence ID" value="TBU13558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0394p0010"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="193"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="33764" checksum="D9DC56865F89A798" modified="2019-07-31" version="1" fragment="single">MIGKIKNSGNIKKINISEVTKNQGLESSELIGILNEIDECKQYRNDMGNIHKSIFKIIKNLKLKEKEESIKTKEDLEKADISFLENPAVKIHETNIWNHEDKRFPMLKYNMEYKFPIMIYKKNEIYFKSKLVNKPSREKKQEIPFNKLENKGKKANDTIKYDLLSDKEKIKLACFCFKNLRKYKSSFKDNILEKISNIFRSSFKKDSYHIKKENNFVYTVGDHIMDEGIKKEGLFRISGKYAYYKFMPGVLAAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX9</accession>
    <name>A0A4Q9LXX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0367p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000367">
        <property type="protein sequence ID" value="TBU13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0367p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020756105" evidence="3">
        <location>
            <begin position="22"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="686" mass="80332" checksum="4BDAED7DBD0DA081" modified="2019-07-31" version="1">MKNFCIMQNLFISFLRHLIASQENTCLLSYDVNSQIESDGNSQNMNIFEHIYTEFNDDAIFDEQYNQNFELFTPETSHEIQNSTFLKMISILIIFSTILNHIYLFQLIVFTKSFNALIAIKLPLQQTKIIQSVFCFCNYTPVKDSIFSENIAEFANSASNTSYPAQNHICNTLPIESYDYSLSLNHTELSSNQKNVSLQNSTIPNNCNISSIQSFSDSNKTYSSSVINHSEIRKRRLDNKISQQIKPKKRRNASDSSDEASSLSQDAASVISEVENISEENICTVETKSSFTEQARKTLTSLFSEIEDLNTESISFESMYSKKIYNYIFYYGWNKYINDHIENYNSIIINSVKEFKDVLDVAESLLFYEKYFPGYVSQYEIICLYEIMEGILLEIKNEENFGLFYELIKFVAYYESRLSEYIESNHCLHVYFILSIISNQLKNISFEILKGIKISKCNKNIKCTSFNDEIKEEYLKIFFIQRLFSKLLLGMKNGKLRTQFYIIFIILDFGSETHHKHHYLNQKSYFRFYLLVLASFILEYKFNSNIIVLNTFLKLSLNILNLKMNSQQLFFNETHFMMKTFFLGISTVKLNLEIIDKIKVFANKSSYISENLAYLREKYLNLNTDLSVSYKHLTLNDIFLSEICLSSYLSRQYEDLLFDNKIISIGWKRLYKNKIKSPEYTLDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY28</accession>
    <name>A0A4Q9LY28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0353p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000353">
        <property type="protein sequence ID" value="TBU13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY28"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0353p0020"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="324" mass="37442" checksum="34F78C98BF5D41A0" modified="2019-07-31" version="1">MDEERTLSTIKKILLEKNVSDPFKVAREILFLYNIAAKGMSYNEDILISCVEKVLSKNDNMEDYKENEEINYYRKAANIKLEPNIVKLRRKSVSGKRANINENDIQFYDKDSQTFAMLYNILEKSLLFQFLNPKQRRKFVWCMAPLTVENNVNLINQDDEGDKMYFVEDGEFDIYKDGEVVGKVCNGAVFGEVALLYNVPRTATVRSVRISKVWFITQGCYMALKIVDEMKKRDFLEKRLGEMKELKFKDKKTFLKVVNGSKRVFFREGTRIEIKKDYFLLVTDDGVINDKKGVAKVCVGDFIESDGLVAVSEIEGFLVPSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY33</accession>
    <name>A0A4Q9LY33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">La domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0500p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0030"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="355" mass="41600" checksum="6876CFAF00A4BE78" modified="2019-07-31" version="1">MTIENLDKVKKQIEFYFSDSNFRVDKFLRTEALKNDGWIDIQTILTFKKMKEYNTTLEMVKTAMNGSTLVEINDDKIKKIESEKYKEYIMKEEHSSSFAVVKGFDIHMSFEEIEIFLSEFVKPRLIRMRKDRERKFNGTVFVELGSEEEINEFLKLKIKKPILKNEVSLPEKNEDSVTKHDDDIKKEKIDSQKETKEEALVEDSLSEDAILKNKGTGKREREDAGEDCDRIKRVKTEANDFLVLIKMNDYLKEVPSKPTESEKLIKSMEGKFYKFEAEGSIDIKTVKRIIPGVAFVDTQKNTLRFKHVPEFETKDFESEDIKIKVTKLNKTESDEYTSGLNLKPKPVKKGRRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ5</accession>
    <name>A0A4Q9LYJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative subunit Rpb4 of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0562p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000562">
        <property type="protein sequence ID" value="TBU13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0562p0050"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13135" checksum="4907715E5F78FA4B" modified="2019-07-31" version="1">MKIIKSVVKFLTRSDVYIFLNQSVPTKDQTTETLRYNVLEYCSDSLPKDRIEYIVEQLKNKNLMEIEIYMLIDQPPKSLLDLQLIIEEMEERYSEEELHQILMLFRMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN6</accession>
    <name>A0A4Q9LYN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0291p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000291">
        <property type="protein sequence ID" value="TBU17010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0291p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24311" checksum="D87C645D2BFCF545" modified="2019-07-31" version="1" fragment="single">FKSSKRIRSHSVQEILDNEYAEIIVDTRIKTDVKIRNNRLDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGILTKYHRSHLKRLEIPKLIKKTVETISFDRRRGLESGLNVEESWERASIDVIERFEEEYGVKNSKKRKNTPFISQGGTTLEEPTNNINKESDLEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV1</accession>
    <name>A0A4Q9LYV1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0586p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000586">
        <property type="protein sequence ID" value="TBU12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0586p0020"/>
    <dbReference type="OrthoDB" id="5985090at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="36567" checksum="1C287296D5E84FB0" modified="2019-07-31" version="1" fragment="single">ILKTLHIRNFNLGYRELFLIYKFQNLKSLILENCIFLYDNYQSFSDFQQNNSLEHLTINSCIDPLHFFSSIEFYKNLKVLNIENNILYKISKRIVIDVHDLPKLKKISLNSGNFTIIHIKFGEKNTELRELELPACNLPENSFYNISFNMHILNGIRSFSYFKNNLSLYDLYCVSFMNNCNFFDISCCIFHDCRFSDIFTVNKTYKISELYIFGLNLNNPDIFAIRNLKLLTHICISIDLIPSSAIYLFKYKYFERLQSLDLSNNVIQRRIRDYLIEEFGNILEPTININEESDLEEETTVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY1</accession>
    <name>A0A4Q9LYY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0261p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="49944" checksum="B6ED4EFEDBBCBD19" modified="2019-07-31" version="1">MKRNLLGSAIVFMVMKFSESRSSYNSNIEYMTTRIIPFLPHIIMCMKGCMAASKQPAEIANERVESLYIEDNYCQTSISFYVSYFILYFCDDSVKEKERRDLVKKCLISKIDASGIAQPRKEEIIQRFENIWNASSVDNHESDFYLAMDYVLIKIALEAEKDIVNGILSIKSMSAALLTHYFFRDIMTLKLMLAEKMIEMAQSEHLCPCIRDPNFFESTALRYTDYMSFEKMCERYRTSIPSVDVNVLMLFYDIEGEFLHEALINMRSEIKENIYQELAEKDVMVECFADLFLSDINFTTTELNPGSTFPNEKLKVITKDAGSEIYNFVSPIILEMIGNITSTQRFKNIVRRAVNSIQKEMASKEYKENQSQHSNDYKAAVKELEKTLEDTAVEKMTQAFSKANPSKDEISVEKKTEDEGQATGEELVGAVGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ58</accession>
    <name>A0A4Q9LZ58_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0389p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000389">
        <property type="protein sequence ID" value="TBU13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ58"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0389p0040"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9503" checksum="6DB64B21B341619D" modified="2019-07-31" version="1" fragment="single">MDHKIESIILLGPGIDIFPITTMEYPKFTLRILNKPLLVHNIQWLEKKSSKIYIIGLEYYQVTVNNYLEEFKLSEKTEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ92</accession>
    <name>A0A4Q9LZ92_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">leucyl aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0485p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000485">
        <property type="protein sequence ID" value="TBU13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ92"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0485p0020"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="334"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="490" mass="53996" checksum="8CCBF4FA2A7D81A2" modified="2019-07-31" version="1">MELLNWENIYNVVSNLDSDNNGMLLMLEKEEEEYKLHGDLPDNLSKDIKTFLNKIKAKGDLSEVFLFEVNKDYSLNISFIALCGISSKKSNLADSVMQASGLGVEILSKIKITDIAIPDSELFASVVQGAILSSYSYNFLKEKKEETKIRIAPWKNENNFKESVEIAISQNFARFLADTPANLMTPSHFVSYAQKYLDDKNGISFEIYEKDFLIKNKMNLFLSVTEGSEQPPKLLYIKYKGNNSDKVDLGLVGKGITFDSGGISLKPSSNMGDMKADMTGAAAVLSVMGLASFFKRKINISCVIPLCENLPSGKASKPGDVRISMSGKSVEIDNTDAEGRLVLADAITLIQKEKPEYLIDVATLTGAICIALGPLYAGLFSNDFKFTEMIKNAGMKASEEVWEMPINEKYKKFITSNVADLKNTGESREGGSCTATAFLSEFVEENTKWAHIDIASVMSGSKVNSSLFGKGMTGYSVRLLNALMETLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD1</accession>
    <name>A0A4Q9LZD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0370p0060</name>
        <name evidence="1" type="ORF">CWI38_0458p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000458">
        <property type="protein sequence ID" value="TBU13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000370">
        <property type="protein sequence ID" value="TBU13657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0370p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0458p0060"/>
    <dbReference type="OrthoDB" id="2194154at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16298" checksum="7D86F8555F90E1B3" modified="2019-07-31" version="1" fragment="single">VEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPKIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE3</accession>
    <name>A0A4Q9LZE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar phosphate/phosphate translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0220p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0030"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="9"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="315" mass="35645" checksum="1BA030D5B3F90C15" modified="2019-07-31" version="1">MYKSTLTIISCIILYYTISLTLSFFTYHVLSSKQYNFRFPLFITSMQNLIHFLMATLVTLIITKKPPPLTLTLPNITTYLTTTIPCAFTASLDIGISSYSLRIVSLAFYTMVKSSAPVFVLLSGFVFGVEEPSIKTFLTIFTIGSGIFLTTLTNTSFDKYGFFLISFASFMAGFRWAFVQFLIEKKKLQKNNILNTIRDLCLPICLLLLSLSLIFEGYTNIFTSEFFNTPNAIKKNVMVILGSGVLSFCLLCSEFLLVSYTSVVFLSVSGIFKELVIVFYSVCRKEVTMSRINYGGLFVSMVGMLMYNYCRKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ5</accession>
    <name>A0A4Q9LZZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0171p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000171">
        <property type="protein sequence ID" value="TBU19924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0171p0020"/>
    <dbReference type="OrthoDB" id="2192914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30744" checksum="60952E97062D1017" modified="2019-07-31" version="1">MTYYKTKFQKKAKNFEFSAESYVLSEEIRSQYKKIKDKFFISISALKNYKSPKKISISSLIDTVDYMKEIISFYEDSDRYISILMTEVFKSNKIETLEKKRELYLLLNKLFKIFFIFDIERHRNILLFHNFSLLKILLHNENPRKRFTDNDILRLTSFAALSQPMAHLFLSYFTSDTLEILHPTILTKRGTLHISPKRKEFLYLICCILCKQPSMAYAFIFFAGLFNRFFHSGHFDNYVEEKDIQKQAYYTGILEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I2</accession>
    <name>A0A4Q9M0I2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0126p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000126">
        <property type="protein sequence ID" value="TBU20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0126p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="493" mass="59655" checksum="29E36025A4484DEB" modified="2019-07-31" version="1">MKMYICLLIVLFFQTYGSFYNKFLFLRKSHKLKKEDGKYHKDLVVVFESNNRTLNREIFEAISNSRILLKDYIKIYYLKIENSSYLNTLFSKIRNKITETIKIYGCLEREIQEFIVIKTIFDEIFNLFKEDLNAVCVKYREDCKQIILELKEFLTKKFKDKIVKNPMPHFVKNNHCREISISCNDIKVKLSIYFKSFILNLLRHLFTYFGNFKIFAQEVILKNHKITYYETTNHKHLNHIFSSLKYEKLDIDTLSINFLFNCNNKNRLEDIINIAYYEISNNKSFMIEKRYVEYILFCLTDKVMNSKIEFSKNLKNTEEKYITLDKKTFPLTKEILKMYKRLDLVIVLNLEAVFLDFLKRFLHILLSKKDKKNFPFKKSIFSLRNADLNEFYCFETREKKQIFTIFNETPLRKIKNAYFNDVSTVITVFIDKFDAFLSIYFKDSQPDYKVKSSRNMEKKTKFSFYNKVFKMEFLRLIKEYLNSSNIFIRELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L6</accession>
    <name>A0A4Q9M0L6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0122p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000122">
        <property type="protein sequence ID" value="TBU20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0122p0020"/>
    <dbReference type="OrthoDB" id="2193863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="11892" checksum="5FA72D85475A69B2" modified="2019-07-31" version="1">MSELQNHELYVYSALFLREREGVVTVESLKAIFEHLGLDFSHKLASQFIMPVEEYDRIISNVGSASSVCTTADNGAAKVEEKVEEEKKEEANIDGDVEVDFDDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T7</accession>
    <name>A0A4Q9M0T7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PelA-like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0326p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000326">
        <property type="protein sequence ID" value="TBU14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0T7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0326p0040"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="350" mass="40772" checksum="34DD3DC40B2A59EF" modified="2019-07-31" version="1">MKIHKKYFDEKKLEGSIELMPEYPDDIYSLYNLIDKGDIIKSRTQRKIVVSNKNTERIYIKLEIVIESITVDLEANVIFFKGKTLTEHEHIKMGSFHTIEITLNDKLWLTKKEWNLLSLKILRDAETEYTEIFVVLLFDKECFVYSITQNYVKNILKQEIKNKNYKNIITFLEKANLKIIKSIIIASTSEERNIFLKNISSNKNIKENLEKFCSVKLDSDYSKMSGNKIIEKMMGDAVVLKKLHNVQFLKDLKEMEVFLTLFNTDSEYIAVGISDVQEGIEYGAVKSLLLTSEVFKSFDIEERKKIEKLILDVKAQNANLFVIPIRHFYGEKLAEMGGVAAILKFPYRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X4</accession>
    <name>A0A4Q9M0X4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0192p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000192">
        <property type="protein sequence ID" value="TBU19827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0192p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="19033" checksum="82BAA4E029C84D69" modified="2019-07-31" version="1" fragment="single">MGVSICKRRCFQNSIFTNLISIVYILCFFKLVSPLVLSYRLQSIKHSKILIFDEKKQNDLLFDQNSKYLNFYVLNNLESPSCDEITYDFIYSKENFIGFEVFDNFLNSSRMENVNMKIECDFNLTYFLRLTNDITNTSSKINYQVFDCLLFAMKSLDVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X7</accession>
    <name>A0A4Q9M0X7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0091p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="30435" checksum="7785BCA9EE73B6CB" modified="2019-07-31" version="1" fragment="single">MQNLYLEFTLIFMSDNYILCSSSSEENEENNLTKIEIPKKENLRYYSKKTFSLNFSYENFLFYKNRFIGKNSIPSIYDISFPDGSSWNNQNYIRKQIKKNTAFFHVNKWFSENLNSKFKDILSKKYKKIEEITKKEIKCEIINVIDNTVPITLPISHNFIPKKRNKYDELCSFILDYSKINDLDSLQDKETSISSSCLYLIKESVLSRLLEKDTQIYFEVVFANGIKKYLFYDWMKEAFSYEESILKYMEERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H3</accession>
    <name>A0A4Q9M1H3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RasGEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0051p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1H3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0050"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="98"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="37072" checksum="39A08CE9AC06EB6F" modified="2019-07-31" version="1">MNEKVDNFIKYISVYCKYGETTIVPYKTFEELKNIKVDVNEEENDKKMDEEASKITFLWSTDILPLSRYQIILKKGVNESKWKLKMEKICQRTIMDFKSNSLAKILTIIDFEMVKSIQPSELLFYDGSKESESKCPTLSQLKSKNNCLKNYISYEISKNRNSIYKFLKISKKLLLLENYNSLNSILNGIRTHKLNSKELDSVSKVFDKCKTYFQIRQLLDICFQKKSFFIPPLEIILKDIEDSNRNKNSLIASKRFCKLIEFLILVQNQKFVKKINKKTEHFILNKMFVSRFYSAKRKKICSKKYEGSYFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J2</accession>
    <name>A0A4Q9M1J2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0460p0010</name>
        <name evidence="13" type="ORF">CWI38_0032p0040</name>
        <name evidence="12" type="ORF">CWI38_0048p0010</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000460">
        <property type="protein sequence ID" value="TBU02532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1J2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0460p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0010"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="4"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="426" mass="47794" checksum="710E96E802651C92" modified="2019-07-31" version="1">MNGFFSGYINLLKTAMGSGILTFPSIFSTYGVVPAFILTLFSACFSASGLLLYMFCSKKYDRSSSISMLCSENFPKLKFLVDFGIFIKCFGVGTSYLIIIRQLLPNVLQPVFGSNLLTQANSSTAIYLAIIASVCYFRNLNNLKYTSTCGIIAIFIVILTSIYRLFTSPIQSPVLYTSFSSKWIEGLGKLVFAFTCHQNIFSVRNELPNNSTRNLIRLIFATILTAVIAYTTFGLSNYLLYSSSVTDNILQRYSSDTLGILIQFLYVIVMGFSYPLQIIPARMYFCYMFMPKYNNNMEYVSTRTDYRNTNLDIASISNTNQITNTNLPTSHTTTTLSETIINGIVTTFLIIATYLIVSQDIKLGIVYTIIGATASTLMCLILPALFYLRSNDNRRNIYSFLSYFIFVVGIGIFCITIIDLLVVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z5</accession>
    <name>A0A4Q9M1Z5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0026p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10658" checksum="92D52EF7907621C4" modified="2019-07-31" version="1">MFIYFYFVYVLKKTDETISFDRRRGLESKPNAEESWERASMGVIMRAEMHEEPTPPLKQSSRGQDGGPTININEESELEEETVVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M252</accession>
    <name>A0A4Q9M252_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0231p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000231">
        <property type="protein sequence ID" value="TBU18734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M252"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M252"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0231p0020"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020733299" evidence="1">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="48730" checksum="FE6C5BEAD3D56A91" modified="2019-07-31" version="1">MNEIILITLLIQIYCTSNSYHAISKENKEERKQVQIKEIVTILYEEYYIDIKFIIEGGYGKIFRARHLSHPNFVALKVYTDEFFSFNDIMKEISFLENLNHPNIISGKLFCNNYFYYLEMDFYEFDLFRYVRAFFLSINDKKMILKQVLDALFYLKSNNVIHNDLKNNNILIDKKLNIKICDFGFACKKENLIFPLKKFSLSILEKFEFYSPEFKKSIEYDEKSDIYSFGILVYFIFNEINYKFETYKPITDTESHNMFLKCKELDPKNRPSADSLLLSRYFDFLYEEMFCFGKLKDFIIETGFCSIIKHDKTLGINIKNKATVDVYCCCHILTSPLYISMSKELNLKENCRSANNNSFNQITTKRFLYVESDGIFKPIQFMPQLDRIEYLDFFYRNKKYQAECEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M299</accession>
    <name>A0A4Q9M299_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0221p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000221">
        <property type="protein sequence ID" value="TBU19107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M299"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0221p0050"/>
    <dbReference type="OrthoDB" id="2186513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10543" checksum="D722B77CDA6C6BD7" modified="2019-07-31" version="1">MEIEAKQYYKKHDLFMIFSVYLKDRLKEIMGIPVKNFLKFLFDNYGIPAAIQSDNNKEFENELLETYLTAFNVQIIHRGPRKLKAQGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B3</accession>
    <name>A0A4Q9M2B3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0091p0010</name>
        <name evidence="11" type="ORF">CWI38_0261p0070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2B3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0070"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="25900" checksum="0CF51D40B8985D98" modified="2019-07-31" version="1">MIKKTGTTIIGLKYKEGIIIASDRRATSEYVVDKNCKKLHKISPSIYAAGCGTAADIENVVRMCEKEMSIFCKKYNMPGDIRMCVNILSQHLHSYGGQIGAGLIVCSYSSASRDDGGKDTNNSSSNTSYLFNVHPHGSSSSHEYTSMGSGSLAAIGYLENQYRRGMSKEEGIDLAIKSIGLGVYNDLYSGSGVDVLVIGETVESIYVPLCKKEERDKIVYNRDSVVFIEEEVIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D1</accession>
    <name>A0A4Q9M2D1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0015p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="734" mass="84802" checksum="92B4060069FC2F8F" modified="2019-07-31" version="1">MASQSNLEEGENNQNSFKIDKFNTGKWKSVSREWQETIEIKNTKKSTESTETLAHSVFRVESGSKDGAKPEQRNVDTSDLETMIDKKLKKLGIYDRFDNETQRRTNICKKEPECSCTKPNVKSKTTGNDGIRELKNQQSNMPTATKKTGDNLNDKVSALEKVEINSGSKEGSDNKKDGIFFTKEKEKLMSQDYEKIKIHKRDIIGSRKVNSSINDFDYVLSKENPYDSEPSILYKVIKKETDETFTSQNPETLHPNTEKSIEKNELQITDVSKSNIGGLTSQRKSTNEASLSNSENDRRYSLENESIFEAEKDEKIPYRGSEIESKAELKLKNDNLKGFEFLVREKQTDYLEKRDQIEKDRFDHARNQQKSSKKINTCYDTQEQSPHAPEQRSEVLNIKAMDSNKKNERYFTNDPRRLQETYKDWLKEIYGDYYVRKKRTPAFPRSRFQIPKILEQEPRGSYTESTTEVEVVEKHTVKRIIESSVFPPPNNTEECPNKSNRDKNSSIFDNDLFFRESREIIDKIRKDASKILGENKEENSEKPVTKSETLEEEVSKILEKYHLKPKLDQDNKSPNDGEKLEVDLVSNPKKSINEILERQKSEPVLIKVKEECIESKTPILVAEKQEKEQKEEIKGEKCMRTIEGQENYGNTEPSNPKYASENDLSRLKPILECDKQCSSSIMCGGRHIMVENTGKEQKSGFKFEEKAISSPDLSKNKTKVKEKEDKQKKKCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E9</accession>
    <name>A0A4Q9M2E9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0366p0020</name>
        <name evidence="2" type="ORF">CWI38_0008p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000366">
        <property type="protein sequence ID" value="TBU03046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0366p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="104937" checksum="1EBE7B834FD1DC76" modified="2019-07-31" version="1">MSKAYINVLTNHKNNKKMILGANKLLNNIFRRTMIVKNILIASLLILFLDFNSGFKIEISFLNEDENIGHDLQSDMDSLENTNCTIHETYSVPMEKMDINSMFAQTTNTETIYLPTNTSNENPVILSNEIIPNLTIEDPVEPKNIYAYIQEKDFKGSTANINFPEIFSNALNPNITSSESHEHEYSSISDIGFIITNNSSIIFDYSDEFVIRSKYFEEKCNSNSEIFKLNISDITSGNIDIFNFGVFLASLRFGYDPISFGLQKDFFLIFIELFYDLNCYSQFKVFQDLFKNLYPFFVSYKMSIDAVYSSVDTAEDLKRYRRVFLPFLSLFYGSIDIFIDAKKSELLFLEKSRYKKIYVFEKDDIKTIRIRTTPNIINLMIKTDLGRENHELFIWIVSLYDIDGIRVSADNSYYSECIDSDIACKFLCAFSNVTDIKPVSLTCLLNDILNISKHSCIKLLELERVYFCKKMPIQPEMFPNLETLILVKCILNKNCKFLTSLHKYFRNLKVLRIVGFSLYEGFFKNLVFDYLEFLDLSCCRSIDVTQQMNFLLKKCEYKWLKIDYSEFNVMILNFLIDNVSLQRLSLRNVNFDKFMYSGNFYGRQSCYYYLDISMCRFDRFYSTNYLFRNLAVWMLSLERSDCNECKIILSQESLHNSTRNLSLRGSILDVEISIYLKMFKYLENLNISDLPIKNPEILKNEFLFNVSLLSIDLSNLTIDKEELLNLSQFKNLRDLKITGCNLSVSFIKDLHKMCFYESLEYIDISKNKLCAYDIYFLKLAFCLTHLILTLETNIFSNFDFKLLGPCFKKLKVLIFAQTFVDENIFDFILTTPEITNLEFKESRIEKCIFSERICNSLKFLHTINFFNTILSLENMIALEKIQNNGISVNFSNSSLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F5</accession>
    <name>A0A4Q9M2F5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0084p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2F5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0010"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="38151" checksum="388642748909322D" modified="2019-07-31" version="1">MNLNNDDKLRLGTTARKIVENGKGILALDETSKSLEKRFALRNVTNTFENRVKFRDIILSTKNLGKYLGGVIMNEEMLNERSELQNKSFVEILQEQAISIGIKLDKGLIEFRDNENVSVGLEDLEKRVKNSKFKTAEFAKWRSVFKVDEVLPSFDCIEENCVVLARYARICQENKLVPIVEPEILWEGEYTLKRAQQVTNNVLSSLISHLNIQGVYIPGIIIKLGYVTPGRSNTQVYSYQDIGISTFTSLISTVPVGISGVVFLSGGHNFNDSMEFLNAINKQKGKRTWNLSYSYGRAFSDNVLDVWNNKDENIEKAQEKLINLLEIASQAIQGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M359</accession>
    <name>A0A4Q9M359_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0156p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000156">
        <property type="protein sequence ID" value="TBU20001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M359"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M359"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0156p0050"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15521" checksum="B9B597A200B17B0F" modified="2019-07-31" version="1">MSKYMTTYKKNDLVDIKVNPAIHKGMPHKFYHGRTGKVVGVNPRSLVVILNKTVGNKQIRRTLYVREEHVSKSRCNEDFIARRTTNDEIRQQAVLEGNKVKCLKRQLPGPRESFVVSMVNNTPVSLGYEPYVDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3I1</accession>
    <name>A0A4Q9M3I1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0136p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3I1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0030"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="16000" checksum="17A4EEFF83B5501C" modified="2019-07-31" version="1">MFLDCKYNINQILNKEYIEIRVDTTIKTDNIPHGSKNKHIPIKFLMVEMGKLRKYNMLNNNLGLINKFSAEIISYGITNNDICEPNAEESWDKAFLREVHKRLKPTLKQVKLEFNLNETLDLERDNKVVKMVIKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3N8</accession>
    <name>A0A4Q9M3N8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3N8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="23024" checksum="97AFE4C21C15ED06" modified="2019-07-31" version="1" fragment="single">MIGKIKIQDAVNNSAYSDDSSNKTVSLPLKSDELIRLFNSLEKGSMRNKKLLPVHRHLKNQMITKTDVSDKLAVICTKIDALANFKILFCEFDLKYLVRSKHSINKCTSIVKMENIRVINQKKVQKKYCKTSLRVLEYKETVQYSYDKLEHNQRKKISSYCRFKLLEKPKKRCDCFLGMFKNIFSFGKNSKIDQKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3U9</accession>
    <name>A0A4Q9M3U9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0014p0120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3U9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3U9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0120"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="25287" checksum="F03DEFE402B767CC" modified="2019-07-31" version="1">MKKALQVVGDSDYLRKKRIEFLKNRERYLETSTKMTESHREMEYILLRIERKLFFNDIEPRIHRRIMSEKPIFPENGDLVAHNYETNLKKVHDDGFNATHKQCTNTTKRSTIETMKANQSIFDQQSLETLKIRKKYPCLYVNCEKSYKNANGLKYHLKYGHTLNPVVKQFRCDVEGCIKSYKSINGLQYHKINEHNHKKIFKYYDSDNSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3X3</accession>
    <name>A0A4Q9M3X3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0109p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000109">
        <property type="protein sequence ID" value="TBU20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3X3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0109p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="787" mass="93893" checksum="90B8E05CC6E685D0" modified="2019-07-31" version="1">MRIVYFKERLSSLVFSLNLYFLSVIGKNVIFYSIENTEIGMNYIENEETVIFEFQLKNKYILKSFKSVFLLQNQYLKCILRNDQIKYYTPNTIEISDSENIILDLFADDREQDNLFTIIFFLGQLSYDFLLRFTRYATNNDVFLNTLSFIDFINILTVLEILGFKRTTKNNTFFKYLLLNSILNRNFDFRKLNKFLNSKQYDYDRFDMSLEYLYNIFLKFLLIEKISNFTFLLLKTNSLVLDFKIIISFQVYMRYKEKLSNTSILIFEPNIIIHLEKLLSTDWGKNCICFFIKYCIVDTFCFVFTKKEPSKKIFNLINLIKPNNLKKIILTDMLNNKTGIKALLLFGYFQITEYVKISCDLNIEEVLVILKHSENIKKLVIKSQDAYYDILFELNKFAKSHKNIYLKYKCINLVMICQKNDLFQNISENLIFYIKKSNISFLHCELCFMRSFYLLRRIKAILSNNNHQLQKYKKKFFFCSNVKAVYINMEPNEPSETIHPKLVNYIFQMQKLQDIILENIIFTDILIRNIIENKNLISIKIFNSSIPSELCQKYKIFNYNLRVITVKNTILTLNMNFIKFISLFRNLIFFKIYIKNIDPVFKKMMVNSAANIYKTLKYKSVSKLEYLKIKMNENITTCLPILFAFSHLFDISNLNILVLQCVKLDVNDASVISNLKNLKELHIGVYQQKNEMFLNLLNKILENKKIIRLGLDIRNLNLNIFEYCCNFRKIQLVFIRFKNIEAYDLTLLHKMKLTYPNNVAFFCEYYSLVSVEVINFCEEHNIDFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M410</accession>
    <name>A0A4Q9M410_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0065p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M410"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0040"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF42">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="27281" checksum="DCCE2B37A184003F" modified="2019-07-31" version="1">MKKILIGNWKLNCSLEKIKWVSGFRREDFKKIECCVAVPYTHITTAKTDFPSFIKVCAQDCSKYEEGAYTGEVSAKMLKEIGVEYVIIGHSERRRYFDEDNSAIGEKVKRCLLSDIKVVLCVGESEEERNKQLVLNVIEEQIKSVAEKLSDMAIIRMDVAYEPVWAIGTGKIPTLHQIEYAVKHLKTFMNANRIVGRILYGGSVSLRNFKLISEIAYVDGLLVGNASLEEDFIEMAREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M430</accession>
    <name>A0A4Q9M430_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative histidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0004p0080</name>
        <name evidence="4" type="ORF">CWI38_0006p0050</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU21001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M430"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0050"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120571" evidence="3">
        <location>
            <begin position="27"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU21001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="45492" checksum="4C566AB197B600C7" modified="2019-07-31" version="1">MLVISFKTLKATSIWILLLNLIIIKAQEGTHEDYRYIDTEPKLSAFKKYCESEYLYSKYEPGYELDKVILVFRHGDRTPTRTYNSAWKREQCVVGETSLNTHSISNFKYRNCENGDLTYKGYNQMSKLGYFIRNNYFSKLCQNTSDLNNCLKLRATHVKRTHTSLNGVLYGMIGNSLDLDVEIPKSSLDALLIPLQCRYLSSIISKEKDEFYKSVKTEYFNHKKKYSGHNISDNYQTHICNKIPVNCKELSCDIDTIKDYMTSAEKTWESQSKTLQDESVLRFVFGRFAKRIKEILQEKEKMHIFAAHDGSITFLMSGLGIDSRVQPSYGALLAIEIWKNHDKKYIKILYNGNPVQSTIDKNSYISEEKFIKYLSVLEFDQEELSEKCKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M478</accession>
    <name>A0A4Q9M478_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0055p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M478"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="867" mass="102689" checksum="EF63EC77B9D1B3D7" modified="2019-07-31" version="1">MKLQTKNINFPILTKIEELLQINQLPLNDDNIINACIEILDQTLIQKQDLYYLELLKIIYLKKKQISLEIFLNKLDKTLLKILESIVSKENLNVSYLRIIFKILIFLSAKNILKENLFFYFKIASSDALIKKKTIKIFKKYLVKKNDKIYDFIIETYKDGTENEKVSIGEILCIFNEYFFKHFYSKNLLDILVDKNLKIKLERILKIMAKCCSKMTENDLNIYLETIYFAFDKIESNYEIIAILKEIFYKNHIFRIKKNVNIIEFDVKIFSIIENLLLKCSSRKEVNFLSELLEYLRYFYEPYFISTFIRLSSKFEDKPDLQTCILLRKFIKYIDFMKYYNIVNINTWIPVFRNISNKDISIFLEIYSKYSIESVFAIFPFFCNYCSDKKNILSKLISIIIENKIMNNYILKGITNIIISHKNNLLNDLRLENNISKNESKHILEILNESKIFDFIFTFYKEKLENNLSLITSDMKECIKCLLNLKNIDFSKGLIEYINEYKQIENKFEDRQGFKKGPIENIDNSNQMKNNIKNSFLNVSDQGNSIIFFYNDICPQKIEFAFFSNEKIISEIVLKNKILEISCLFTAVNLLSLFLEKIQCSHEFIGKILELCVENKNQKVKKICSNLLLQLINVKKIDLCICNYIQTNFENGKYKFLILSSLYFIGCNNCSLQNKENLLQIIYNEMNTNNKLKILNNLKQEWKIQLLENSIQQPDTLKLSVIHNLLQNIILTDQLRNKILNFILEKNQSSISKITVEILVHLTNFNLEKESLNKIMNYISINLQILISSNLKGMKVLVKNLSNNKVSLPSRIKNILSIFKKNKNTKRTASINKNNFIEIKEDLNRKNYNKNKFKLFENNKRFRKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M487</accession>
    <name>A0A4Q9M487_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation elongation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0052p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M487"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M487"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0040"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="792" mass="92729" checksum="581DCF494EC34F19" modified="2019-07-31" version="1">MKSEKHVAISAVIAHIDHGKTTLIDSLIASQGIISKSSAGNLRYLDTRTDEQQRGITLKLSVVSLEEKNTNNSHIIIDTPGHVDFETYILRTSYLTDNFIIVIDILEGITPRMISLLNYTKNRKCILVINKIDKLLYLSLNELYCQIETIIHKINTLIGSDMFFWENNNVIIACSILCYGLNFNTFYKKIDKNFKEKRESINDITKIGNKENISQNKNIKYLQSASLKNAVKFILFIEDKIAKKDIENLIKRFQVKKRDRKNIFMEILPLSETLFDSINNCYKDNLETRTNELSDKLQDLNIKGNYMTESNFGGNTFKENLNLDYHNFYNYFESKADLLWGVTTYAVFKESGFFNLSNILFVTRLFSGVIRVGDTVYCLNGNEFTETKITKIFLSQINSYLSVMECCAPNVCFIEANFKKNCFITNKDNVSYFKEKLNAILKYKNKEFIQETIDNIINLNIRTQPFYRSKIVPIDLSDLDKFKEAIKSFSYIETSLKAKINKFNEIEVFCEGKVQFEKIINDLTESGFMLTSSDFNSRFCEIILNKSYKEYYHDNFIFKISIEPLKEIQNCLLLEYESDQSVEFINEIENINEEKVMFKESIGYINVTEKYSDLIRNVISVFIKNGTLIEEQIYNSKFKVAFYLKSEEDLKITKSELFSNIKKYITQIYTSAMPKIVSYYYRCDLLCLEEYLGAIYLILQKHKYILIEEEFEQETNFFRIKAYIPQYLYDPFIDDCRLKTKGTAYFVTSDAGFLYSLLNDFDSHIDFLRKQKGLYTEEKITEDPEKQRTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M590</accession>
    <name>A0A4Q9M590_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0028p0080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M590"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="268" mass="30759" checksum="BDF6793CA613D623" modified="2019-07-31" version="1">MFKVVRLVSRETYEPISLQILEKNLPNQNIEIKIPFHRTVLIQRYIPEAFAFFEKTNIMISLANQALKLKICKLLEKKLTELKLKTYFSIDSNLENYFIYLLTLELDNTPEAPSSLEPVSLLLPEPESKPVREPETLREPETKQEPALKREPETKRETAPKHASERAPEAIANKSFKNVHKKENTPNTKVEQNNNGNNLENLTEMTSGSKLKKQKSNTLESEIESKTSEEKLQKGNNGFITILIVVLVFTSVIGIFAAGYWIYIKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5A1</accession>
    <name>A0A4Q9M5A1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0027p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5A1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="29242" checksum="629A6A9F69BA928E" modified="2019-07-31" version="1">MRDICIKYEYQQVHHTETSTSSGLTYPQQNDFVFYNPYFTNIYSNTPNPTVSANAHSSSNISARFQPYVIPARPFSFPTHYSNPSQYFLIQQPNPYFIFQNQNFFPVHLPSGNPNEMFFPDSSNFISLSHSSGMNATLIPWIYNGNYTPHDGSTEQGINPEVIRESQVATNASDAIVSIQRQILQTESENNPICSTSEIKRTITAIISDNEEPHSYISFETDHSRISNNQESGNMSQSAELRYEYLNQDNIFDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW04</accession>
    <name>A0A4V2JW04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative POP1-like ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2650p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002650">
        <property type="protein sequence ID" value="TBU06062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW04"/>
    <dbReference type="STRING" id="1176355.A0A4V2JW04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2650p0010"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="21868" checksum="EE1C83C95124134C" modified="2019-07-31" version="1" fragment="single">MSEQEKEIDALKFITAREFEIKEMEDSLSKSTKKSQLFQRLPFYKRRRTRNYDTRNTPKIHKKYLKKLYLNRFRNRKLKFNYLPTHIWYAKRFKMIDLFNSKLPYKRNIKSDKFIYKSLERGFIFDESFKRIAVFKRNEIGNREDENINTIKSMQMKMEKKTVNEEELNEKLHSNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX76</accession>
    <name>A0A4V2JX76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1599p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001599">
        <property type="protein sequence ID" value="TBU10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1599p0040"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="433" mass="48309" checksum="FDF9D026F5683BEE" modified="2019-07-31" version="1">MVSNSISVNFISFKRLKGCPTDILIFGCYLVICGKHSSILVCDSKLKGGSVISMGCSVISMCCGNGCLYFGTSKGKVYVCSEEQFMVRVKGIIEEGEGGKGKGGNDCDRDNDCAREDIDGGKDIDRGDIDRGNREGMDKDNIKESTHININNDINTNKDININIDINSNKDINNNKDINSNKDINTNINTNKDIDNNNNINKDINIKRYSNSLFMHFRSLKIGSCGVNSMMYCGKENGVVVGLANRKICLLRSGVALVRTFYGPKCPISYVCVSKGGLVMVIGTSYVKFYIFKKENHLSYKSTQGFIQCGGFYTEQRILVGTDTGYLLYFLISKSTPFLCKPIGFSITSIFLSKKNKCVLGTQNGFIYFFSVTDTDINVLVKAEVYGVVNFIKYFNKSYYVGCGRENRVGRWEVNKEYMNCVVRVKVEDKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX80</accession>
    <name>A0A4V2JX80_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1568p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001568">
        <property type="protein sequence ID" value="TBU10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1568p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="74628" checksum="75719AC5EACC4C1A" modified="2019-07-31" version="1">MKDTSKRDSNRCNSNRCNSNRCNSNRCNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPTTYNTPTTYNNNIINKGRDKCYCNKCYKPYKGYHKLYDNKGYDNNGYDNNINTNTYDNNTNINTNTVLYDKTNIIKNNKISRNDKETVFSVFDRVSIKEGVNICKCSDKSSMEGNGDYMDNTSCYGSNRYIDNTPYYTSNNLCDNTPCYSSSNRYIDNTSCCSNRYIDNTPCCSNRYIDNTPLGNTKNYPCDNTSCYSSNRYIDNTPLGNTKNYPCDNTSCYSNRYIDNTPCYSSNNPCNNTPLNIDTINNLYDNTPLSIDTSNNQYNNTPLNIDTINNTPLPLKHTNNNINIYSPGYPLMSLPVITVQHVQLLYNKEIENTFYILKIQSGNINWYLRKSIHQLREIYNFPLFKTSDNIEKRLMRNKNIVSILNNSNNYYEYGKNKNNYYEYGKNKNINKNNNMNSDINKNKDLNIDINKNMYENENMNNDLNNNKYDNNINTINTNNTNNTINNRNTINKYLFPSFYLSDVISKYEIYMSFLVVKIRNKFYVFEPKILKNILLFVWECSVVRAVSLENRVYSESGNEIVIENGNENIYVYTQTYEEKEWWMRRIEGIKRSIGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX85</accession>
    <name>A0A4V2JX85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1537p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001537">
        <property type="protein sequence ID" value="TBU10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1537p0010"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18076" checksum="CB7C0F8541496E0D" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVMKSDSEVQKYKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNTPAPSSVEVSACEPSYEMTSPCTLAIPEGNRLMALRTIFDSVTADLKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX96</accession>
    <name>A0A4V2JX96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1453p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001453">
        <property type="protein sequence ID" value="TBU10972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1453p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="42666" checksum="33EB1035FCDEAE34" modified="2019-07-31" version="1">MYDGLSESQRKKIASIVDFYFDHIKTYTDEYLHELLLHFSTLISTISCAANLENNMECSHEFLDHKNIFTHASFESLFPFFLSVKYYNPKEILKMYELTFSVPDTVLIEFSMLLFSFLCFKEELTNSEIVLRIIVEFLFLTDILYIEFNKCKNTERVKSIENKFQTFLDSSYPCHHTVHEDVVSANLSLQHISLKTSNLIEISVIVETFSDQLFLDKLNTAIITKLKKTVNSTSNEGNMREFILYIVKTEKINNVPSTEKLQKEVHGEPSNILHNEIQEDEYGIGCIKSKGTRKYGIHSILYENVMNDFIENELANILREEVRNYLRNICQYDDLQDQVVDVLKNMMEIFQRHLDGLNQNESQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN7</accession>
    <name>A0A4V2JXN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0721p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000721">
        <property type="protein sequence ID" value="TBU12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0721p0030"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="16970" checksum="DC1F02C691950FB5" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU9</accession>
    <name>A0A4V2JXU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0061p0010</name>
        <name evidence="2" type="ORF">CWI38_0506p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000506">
        <property type="protein sequence ID" value="TBU13192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0506p0010"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="10924" checksum="00A4AAA0E7B29B54" modified="2019-07-31" version="1">MQVFVKCLGQNTITVDIPCKSSSDELKGILQEKTGIVSKDQLLFYCNRPLNGCSLEEMGISSLSTISMTQKLLGGVLSENTRTEQMPLTAEIKSVDIVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW5</accession>
    <name>A0A4V2JXW5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0456p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000456">
        <property type="protein sequence ID" value="TBU13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0456p0020"/>
    <dbReference type="OrthoDB" id="2190184at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="35213" checksum="8F31653528264434" modified="2019-07-31" version="1">METVFVNLKDINGDIKIKYTGIYDEKISKIMFLFWQIQEQNEIFVAGIVFEMKEKNIVYISILDSTGEFKPRNMQKGFINGTILALLKYLSPTFLEVFSQPKKEIIFGKSSKNTKKGFLNSHKLFKYWKNIFSEYICCENKKEYKLYIHNNTDESNGIPYHRNTKLNDIYLFDDDPKQKLINNLEENVDIYNFFSILLFRSDFSNGSLLFNVCPCKKHNSNINLEEFNLFDIKEILETLRGLDFSDYQNSLKSTIFFLKKYQLKSFLFKTSKSKLSKNIIEKPIEEQSFVKIKTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY43</accession>
    <name>A0A4V2JY43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0228p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000228">
        <property type="protein sequence ID" value="TBU18860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY43"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0228p0020"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020627330" evidence="1">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="31"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="37589" checksum="38C22932A88BC996" modified="2019-07-31" version="1">MRLQVLLIAIELILTAKKSSKKATWNQNIYPKLKNQNNICYFNSLIQCLYNIESFFDFIINHDKNPSKPVTSNIRAIIGRMSKEKNSIESVSYLENAIFKYNDHGFVLSKQNDASEIFIYIINKMIEEAITSKINEHKSIEAKENKKLRELFYLSFFYKFKCQKCSYASRTNNEITNAINVAIAKSVQEALNEHFKSSEPVEKDCEDCKRKNIATEKRCEIIDSPQILTIIFKTFNNDVKKLQNEIFIEENIVFHRSQYKLKGFIEHIGDKTSSGHYIAYVLKRNTLVYFNDDSKRDLTQKEKEDALNKGKPYVLFYERNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC2</accession>
    <name>A0A4V2JYC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0055p0060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0060"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10234">
        <property type="entry name" value="ASKHA_NBD_HSP70_DnaK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="602" mass="67087" checksum="82F4E3809862DAFE" modified="2019-07-31" version="1">MTSSINVSSGIQKIIGIDLGTTNSCVSVLENNIPIVIENSEGNRTTPSVVSVEGDEIFVGEHAKKMLLTNPTSTIFGSKRLIGRKFMDNEIQKYIKSLPYSTFSHVNGDVWINIEDKKFSPSQIGAFILSKMKETAEKYLNTKITKSVITVPAYFNDKQRQATKDAGAIAGLDVIRIINEPTAAALSYGLDKSENGIVAVYDLGGGTFDISILELKNGIFEVKSTNGDTNLGGEDIDNEIVTYLVDNFNKKNNVDLRTDKIGMQRIKEAAENLKKELSVKKSSVVRIPFAFIDNNNSLHLEEEFTRSKYENIVENILRKTVEPCKKALRDAKVELGDIKHVILVGGMTRMPLVRKIVKETFGIEPISSVNPDEVVAKGAAIQAGVLKGEIKNVLLLDVVPLSLGIETVGGIFSKIVNRNTTTPFKVSQIFTTSEDNQDEVDIKIYQGERPLAFHNKYLGNIKLKDIKPLPKGVPRIEVIFEADSNGIYKITAKDQIDNKEQSMEIIPNGGLTEQEIDRMINESEQLKTADLERKKNIEFKNEIENIVKTTENFITNSVLDSKKVSELNNSVNLLKKMNLEEKYEKKEINEIENKIIKLIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK2</accession>
    <name>A0A4V6MVK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1878p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001878">
        <property type="protein sequence ID" value="TBU10282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1878p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="568" mass="67796" checksum="77E3DB6D9FE616FF" modified="2019-07-31" version="1" fragment="single">MNFFIFICKIINASEFEYKLNLDDSLSLDYNYFEISHEFKADDQVKKCFDKLELDIEGKRKEKMVKITSFYYKKIQEYTNNQSDTFLAYFTTWICYLLYRNTRVDIKRYRPEFLFNLIRFKKFFDFCKEDKDMISNIEDILLKLTTYRLQGKNDNYDEWWKQNYDSLKEKYPEICTNIENSSNRDNKIDIAALENIVLERNFYVTYALIFGINLIYATHEYHFVFFLSLKCMFLSGKKNGIVRLGSLIKKEITTESDFYKIFEPATSYIDKCFKNIDFESYKKITEYISEPIFRKILKVKEEGFEKIYEFSGKKDLFNIEPDDSNRSLEVIKYIVERDEINYINALYVFLKTISKTEYHEYISAVLCLKAFCFKEIVTCKQTMLRSIVEILFLADVLKIEFENGNKNTSAINTHRAQFIGFIKKYLDEKCIEYDKNLVLNTFNHFLLPRTSSILKTFISVELFTNSIWKDNYNKELKEHLTKNKNNADVKLLDNEENIFLDCFEQEFSRLSPEERKKIFTVPAIQTPNSNSRNDAKEFGIKDFLLFVLIPIVLFGGVLLGAYWYIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK7</accession>
    <name>A0A4V6MVK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1552p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001552">
        <property type="protein sequence ID" value="TBU10782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1552p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="66" mass="8097" checksum="571EEDA984147653" modified="2019-07-31" version="1" fragment="single">IKKEKRVILYGYHIFFHHCTRNMVKIKDFEFDIDKNDKFKAYNYIAFMIIKICEGGRFEQESEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KS53</accession>
    <name>A0A4Q9KS53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_2196p0020</name>
        <name evidence="8" type="ORF">CWI38_2480p0020</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002196">
        <property type="protein sequence ID" value="TBT97557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002480">
        <property type="protein sequence ID" value="TBU06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KS53"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KS53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2196p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2480p0020"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000008">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT97557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="186" mass="20982" checksum="DA3921B1D163165F" modified="2019-07-31" version="1">MKKLYKEEIVKIPEGCSIEINNKIITIKGPKCTLIRDLSHITVTFALEDNNLICKLWNGTKKQQSKIITCASIIRNAIKGCMTGFRYVLTAVYKHFPIGIEIVDNGKTVIVKNFVGEKAIRKYQMIGESYARLGDEKDTLVIEGPSIEDVSQSAGNIQNKCRVLRYDDRLFLDGIYVSQRGIIEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3U8</accession>
    <name>A0A4Q9L3U8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0638p0020</name>
        <name evidence="9" type="ORF">CWI38_0574p0020</name>
        <name evidence="8" type="ORF">CWI38_1101p0020</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000638">
        <property type="protein sequence ID" value="TBU01745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001101">
        <property type="protein sequence ID" value="TBU11647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000574">
        <property type="protein sequence ID" value="TBU12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3U8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3U8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0638p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0574p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1101p0020"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU01745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="162" mass="19182" checksum="7D2A436AAD2B6B53" modified="2019-07-31" version="1">MKILICGTPGVGKSFISKKLHVDFLWPHIDLSEYIKSKKLYDEYDQRYDTFTFKSKKVRNSLNKYLQPLESYIIDTHTPEIVCKIKFDIIFILKSSLNVLRQRYEIREYSEEKIQENLMCEIMNVVEEDCREIFGNTNVFVFGENCDSIDYNQIVKEINVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L976</accession>
    <name>A0A4Q9L976_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HIT-like bis(5'-adenosyl)-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0229p0020</name>
        <name evidence="6" type="ORF">CWI38_0815p0030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000229">
        <property type="protein sequence ID" value="TBU03805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000815">
        <property type="protein sequence ID" value="TBU12293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L976"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L976"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0229p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0815p0030"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="142" mass="16826" checksum="57A068AE551E595F" modified="2019-07-31" version="1">MKFGTHEIPEDHIIFKTKYSFVFTNIRPFLPNHLLVSPIAEKMRISELTKEENEDIFETVRNITTVLSKIYEGFTINVQDGVSAGQKVLHVHVHVVPRKNKDLKYNDDIYKEGALDYERVERSYEEMKQETLYLRSLFKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEX3</accession>
    <name>A0A4Q9LEX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2731p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002731">
        <property type="protein sequence ID" value="TBU05651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2731p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9822" checksum="08C69D7D2D183B10" modified="2019-07-31" version="1" fragment="single">MQEMLLATINIDFKENKYDFRVGEKPECIECENDNVLKCLVETSGLHDENLPLSTIPTLRKHMVFINDREGIIDKTLEGYSMFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFW5</accession>
    <name>A0A4Q9LFW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2656p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002656">
        <property type="protein sequence ID" value="TBU06031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2656p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="25094" checksum="68F224CED751F521" modified="2019-07-31" version="1">MLLQLLDYLKKVKKYQLDEQKSSSRKSHYEKFRRSSTCKTIHEIEKRKHHSKLYNARKNEFVYVSDSSRWLKRGNIKPRDEAVFCYIQDRNMVCANIAINLVRLYVDHLETRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNKYAEIRVDIRIKTDFKIRNNRPDIYILDKKKNKITDIEIGITPKIHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGD9</accession>
    <name>A0A4Q9LGD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2446p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002446">
        <property type="protein sequence ID" value="TBU07143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2446p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="28289" checksum="36627844CAA5CC92" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISFKEIKTCDRDVVTISETLPPQPTIYNNTHSPSINTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKFGRTVDIDVLKKLIHNEAEKEIRQEENGERRRIATCLAEPCSLTDTTLYMNLREKFLCKIKELSEKKIGDVVVRTRKLPSELVDSKVLELINRITGEYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGW0</accession>
    <name>A0A4Q9LGW0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 12">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2413p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 12"/>
    <dbReference type="EMBL" id="PITK01002413">
        <property type="protein sequence ID" value="TBU07349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGW0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2413p0020"/>
    <dbReference type="OrthoDB" id="2194175at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="582"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU07349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="735" mass="82842" checksum="5591697A98F8C52D" modified="2019-07-31" version="1" fragment="single">MPKNKNPKVDFKKIMENTKNTKTLEDLYQKKTPLEHILHRPDTYIGSIEKETQTLFVLTEQPIEPTSVDWNVEDIIINSDICEISNNSGINNSSINNNNNSDTYNSTTNNNNNSGTNNNNNTNNISNTNTNTISSTPITTKKISLQQITYVPGLYKIFDEILVNAADNKTRDSSMSILKVNITPTSISIYNNGEGIPIQIHKKEKIYIPELIFGHLHTSSNYDDTEKKITGGRNGYGAKLCNIFSTKFTVETTSFNKKYIQIYENNMSLIHPPVITQYKGISYTKITFIPDLLRFNMSFLDKDILSLLYKRVYDMAGILKNVKVYLNNQRIEIKNFKQYIGLYSNKGITSESIGLYDISVGDSVGVGGNVDNGKLDSNNSNRMLDGNNNNNQSNTTYNNNNNQSTNQSTNQSNNTIVHSVVNDRWEIAFMLSDDQFQNVSFVNGICTTKGGTHVNHVLEQIIEPIIEQIKKKDKSLEIKPFQVKSNIFIFINCSIENPTFDSQTKECLTLRMSSFGSKCYPITEFIKNIIKNSNILERVSIYAKAKQNVQMKKSDGNKSVRLNGIPKLDDANLAGTKQSNKCTLILTEGDSAKALAVAGLSVVGRDLYGVFPLRGKLLNVREANCKQIMDNLEISNIKKILGLQHNKVYLNTESLRYGHVMIMTDQDHDGSHIKGLIINFLDVFYPSLLKIEGFLQEFITPIVRVTFKNKSVLDFFTIPEYESWVRGVGDSSNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH79</accession>
    <name>A0A4Q9LH79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2394p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002394">
        <property type="protein sequence ID" value="TBU07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2394p0010"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20751" checksum="4B0574614302DBB6" modified="2019-07-31" version="1" fragment="single">MIKSKWFYYVSMISLSILVFTYILNITHTYTFVKHNNEILTKKKSDLFIERNSNAFFYFVQVTDLHINTHVKTKGFCHFKECVEEINSINPEFVIISGDIVDSMNEKYDGIVSKQDFCQYLDLVSGINVPVYDIRGNHDVFGLNFDENMEYLNKFMIRKERNYFFEFEKSDNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIA1</accession>
    <name>A0A4Q9LIA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2518p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002518">
        <property type="protein sequence ID" value="TBU06720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIA1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2518p0010"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU06720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="366" mass="42887" checksum="662B3E3E8D4C92B7" modified="2019-07-31" version="1">MFRSRSLTDEKDKYGYNSWDNVELEGEDLIKAIEKVNRDNSLPPKDTEKESTMKRWDIFYKNHKNLFFKPRNWLILEFPEIFSDSTQRILEIGCGTGSSLIHLQDTTKEIYACDFSINALTHAKKNSSSQITFFLHDITSTEELPYSNFDAILLIFTLSSIHPSFHQNIISKLSRSLSPNGKIYFKDYCHMDLAQLRFKPNQVLNKNLYKRGDGTLAYFFEVEEIHSLFSNNYFNVLSLFKDKRLLINRKKKLEMLRVWIQGIFCKEKNNELENRIRKKLRGYLRMPSKGYKSDNIIRHILPNSYKKVIVSNIKDLEALTSLNRFYCAQIAHEVGAKKRIEIVCRANELDILVLNKDARLVSEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKI1</accession>
    <name>A0A4Q9LKI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2221p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002221">
        <property type="protein sequence ID" value="TBU08778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2221p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="399" mass="45944" checksum="22557D603577AFBE" modified="2019-07-31" version="1" fragment="single">MFGTPLLYLPVSSYYGPGYYFFNSQAIPSYTGYIGLIGNNISLPCSPSNYNFNTPVIGHNAPLYSQNEHSCNNQVNTNSSVVVTNSVETSYTEEPFERSANAYTKNSNSTNFKVPVAIENKDSLCNTTNIIHANTSECKDFTDQYMPKRRYAILNRDNILENLYPLIRNNLKIYLRGVFGYRKDIADIGDNIKTKAEEFSDKIEFKIEFTHNLLALFKSGIFSIFYAKNLPIIYLKPTFLLLPIWIVETIETDIAQAYKIFYISWFLQLINATMEYNYSTIKPFIHQDIEGNSRDEFSSIFLKNSNNIYDSFSFIAKYVRNIFEILGKQKLYKIFSHIAAVDFIHFHCDAVFSIEYNCSGIPGIIFDVFILLSDESLVLLNKLIDKYCLFKKMPENNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKW0</accession>
    <name>A0A4Q9LKW0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2213p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002213">
        <property type="protein sequence ID" value="TBU08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2213p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="22173" checksum="4252A282210BA2BF" modified="2019-07-31" version="1" fragment="single">MILCYFLDNEYAEIRVDIRIKTDVKIRNNRPDIYTLDKKKNKIILIEVGITSQDSLQIFETEKLRKYDLLANFLGLIYKCGVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPIPPLKEEKREEDGEKNFKPKNKAPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLA0</accession>
    <name>A0A4Q9LLA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2186p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002186">
        <property type="protein sequence ID" value="TBU09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2186p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="564"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="906" mass="105628" checksum="446BB84713B448E9" modified="2019-07-31" version="1" fragment="single">KKQEIYEKHLQEIKKQTEIEESKKHIKIRIKEYEIQRNNLIEEKYKLDSDNFNSIIEAVKKIPISHQTFTMPISLISLLNQVQVNLPKNYQDIDRCIEELFKKKEEFEKKIEPNMLRLNKQIQEIDEKIKEEYKVLEGMPPTEVKVYKEKKIVVEGVSSKDKIKVGLFLYFITFYFYLYNKTMGRRKKVDSENIKNEEIKVVNNSEISLKETKTCDRDVVTISETLPPQPTILNLLDSTPHSSGPDSSASIEQEWPISTMSAVQKRFERMPRNGWFAILRYYNGKFGRTFNIDVVKKLTHNEAEREIRQEENGERRKFATCLAEPCIEKFLCKIKELSEKEIENVVVRTRKLPSELVESKVLELINQITGKYAESHVPKNVSDAARIIQAAQKGYDEETRKEKPRSAWKENIESKISKLVLFKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALKKITMHESRKQFRKENRMFEFFQRRFYRGLSERVESEHVVNRDEIVNNHSTTFPSLDELVNIINWLLNWIAAGIDDIYNFFIKKLTTLHKYLYDIVKVICSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGYLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKVTWIDVKKAYDLIDHAYLTQCIDNFNLPDWILKFISRKLNEKYTKVTLLAKDSSTLSAMTGEEKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKPISRVERLCHTRLNAKNLFSAINQHAISSINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKTTIFKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEETQLAKLYNEIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMG2</accession>
    <name>A0A4Q9LMG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2229p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002229">
        <property type="protein sequence ID" value="TBU08695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2229p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="693" mass="82642" checksum="CDE73CBAA958D972" modified="2019-07-31" version="1" fragment="single">MQPGSSATHLSKFIEEVSSFAAQGIINFNFFNRSDDPFGLKKHSKTNLIHWSTVMKIHENVLTNYSENFFRNKIQNESFTEKSKIMFLFKFLTYLMKYTFNHELYVIDNRLSNFLYSSDIDVVYSSFLFYNEYVDSENILRNMRMAKHLSIIDLKIFELKHSILNEKKKDNIDFNSVTAKDYSEETLFFYHQIYLYEFYFKKESNKIISIEILAGCLSIKLGRKTNIEILLFWIVLSNLSLSDTHLCTCLEIFFKLIGNCMEQQILIEYFANNFQKYNISSHTVNNYLSSHLLKNDCFSGFILNIEIQSDVVLMFICASVFLNSKKLFNQIYLIVDTLNKLVFFDPILKIPAFKYSKILENLHYRNLIVLNGYMLIKECIYKKMESSINNESRHNLIVNFLYTKCFDLTLLCTNLSSDILENIIKIMLEVGLKYENQDLKVRYLKDTLKFYRKNKITLQINTLYNIVSIINIYRENSMKIKIYHILNAVIIIYFRNIEIAYIWEYFNDILSLLATNLNNLLESNEECMDFKVDFIIKCIFENIEYRKKDIEDFRQMSENFSISITRFKFQNLFISADYHQAIDCFWYNEIHLWHFLRLVYIISSQKNIKFISVSKLYSLLVSKPNNLFFSNNIHIIWEISINFMKNFDVDLFREIFLSSLSDELKMFEMVQADKRSIVFFNNLGYFISFLCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPE4</accession>
    <name>A0A4Q9LPE4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_1936p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001936">
        <property type="protein sequence ID" value="TBU10214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPE4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1936p0010"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="572" mass="64258" checksum="AE8242B86C310D02" modified="2019-07-31" version="1">MNTKEYLNFLKDSPTPYHATQNIKKILLTHNFKELKSLPTDLQPGKYFLIQHLTLLIAFIVPPKTPTSIKIVATHNDSPVLKLKPNHQYTESNIFLSSLQPYGGGLWHTWFDRPLGVAGLVITQDMKKTLININEPFFYIPSLAIHLDNTGIYKNGFQYDKETHLNAITDLKSKQDNSLSRQNSTLEDSKVEGNIRQSTNQNNSSILNYISKKYNLKEEILSHDLSLFDLSIPQTGGVSNNFIFSARQDNLFSTFCAIKAITDISDISNTITSDASNTSNTSDTSNTFNTSNTSNTSNISNTITSNTSNTSLNIVAVFDNEEIGSTTVTGARSDFFIKTIKNIICILKINLQKVYTNSIIVSTDVAHCRHPNYTDKSEKNHSVLLGEGVVIKYSNRYATDIMSSAVMKRLFLKNKIKYQEFVLKNNMVGGSTIGPMLAFGLGIRGVDIGAPLLGMHSVSEVSCVYDLDENILLFKSLFEFDKDFINLCVSGWKRIVDIRIVDIRIVDSIRIVDIIRILDIRIVDIIRILLTKIGFPYVYDPFMTLIEALFRPSTQFGSDSSPLSFQKNYVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPL5</accession>
    <name>A0A4Q9LPL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1995p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001995">
        <property type="protein sequence ID" value="TBU10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1995p0020"/>
    <dbReference type="OrthoDB" id="10624449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17416" checksum="309D46D7844117A1" modified="2019-07-31" version="1">MPRNRWKEIQSYYDEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDTTRFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDTTVLDLINRIVGDNADSHVPMTITDVARIIQTAQVCYDDKTRKERPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPS4</accession>
    <name>A0A4Q9LPS4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1662p0010</name>
        <name evidence="2" type="ORF">CWI38_1826p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001662">
        <property type="protein sequence ID" value="TBT98645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001826">
        <property type="protein sequence ID" value="TBU10354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1662p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1826p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="72766" checksum="2BE47925A0903469" modified="2019-07-31" version="1">MFKFKKDKKFKQIIRIILLSIIYNCQKNYNKGDLTKKNYISSSLFNCILYEFRKIYFFDLKPNFDKEERVSGEHIKNLIVENFDENFCLGKTYVSIKSEFLIKLSKYIKYNKEFKHNFKNIFKWIKPLRVAFDSINSTSDLSMLLPLIYFIPGEELCFQSWKNAVQLQYILENFGFEKIKTLFFIDCNFLSFYESYFESFRSLKCIYLLDSWLLNATASEKTENLIHNLVSIISNEIENKTDASKLEKLNTKDLFKKNFLNWDKSLAFNENFLIQNMFNSSKYMIHFSNTLSISLPSATFKVAILNLQRIFRIDIFLDQNFFIDLNLESMYVSKNVKSLEIKWVDLTDIFLCSVLSLSNLKKVSIFASKFIQKNYETKYMKHISMQELVITHSILIYPERIFKFINSMPNLKKLQISYNTTDIFKHIFNFNMIELVHLEVFIFQQCGECTSGFPKFTNKNSIINLNISYDFSGSLLYYLFIHKELQNIQILELSRFTISKSDRNSMGSCTKIKDITIIGCRLSGISFFEIFDIKKEYAIKRVTLKDMVLGIHDIIFISNLKHLRFLTLNYTYFTPNFFVVSQLVSPSYSKINMGINVNLKFLRFKYRLDEFFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPY3</accession>
    <name>A0A4Q9LPY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1679p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001679">
        <property type="protein sequence ID" value="TBU10563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPY3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1679p0010"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="8">
        <location>
            <begin position="84"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="366" mass="40645" checksum="0E4F941148618542" modified="2019-07-31" version="1" fragment="single">MTNKNGNKNKTKDKPIEEKPSDSPNHNSSKDNPHKHNPSNPHNPPVDSNWLSIGEVSKLNNIHHTINTPSVLSTHLSSSPALTVTRFPPEPNGYLHLGHAKAINLSFEYSLINNGVTYLRFDDTNPRNEKEEFYKSIVKDVEWLGFKPFKITYASDYFDILIDYAFKLIDKGKAYVCHLDLETMRQGRRVGYSMLEGDNDRDILEGVEGNNDILEGDIGSGNYNPVSNSSDNYKGVNNLSSKQQGVNDKASNYNPVNNSTDNYKGVNNLSSKQQGVNDKASNYNPVNNSTDNYKGVNNLSSKQQGVNDKASNYNPVNNSTDNYKGVNNLSSKQQGVNDKASNYNPVNNSTDNYKGVNNLSSKQQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQB7</accession>
    <name>A0A4Q9LQB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1690p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001690">
        <property type="protein sequence ID" value="TBU10544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1690p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="53" mass="6222" checksum="0C9894F68B8BD9E1" modified="2019-07-31" version="1">MEFRPKRIMKTFIEDLNKIFNCINVQKIMIKNLEGSSISVNTMILLSLNSLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQF8</accession>
    <name>A0A4Q9LQF8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_1876p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001876">
        <property type="protein sequence ID" value="TBU10286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1876p0010"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18852" checksum="F6AFB038B90C8C85" modified="2019-07-31" version="1">MNNNYKIIKENKNTRDIKKWALNLTIENMKQYNSTSLYKYTKNKSISNKKSEFIICYFLNKKVGFCMIRKENRLIFIYEIHVTFEHRSKGVGTLLLDFCKKYYLNQKKYENLVLFVLKNNYKAISFYEKNNFLIDKSYADSILHYCYKFNLNNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQU9</accession>
    <name>A0A4Q9LQU9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1566p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001566">
        <property type="protein sequence ID" value="TBU10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1566p0010"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="45676" checksum="EEA844AAE01470A0" modified="2019-07-31" version="1">MPKIVSCKNTKEKEILSSYLKTAQYPAEYFKEEKWLLRQKAEHFTSLGDDICFERRDHLIRAVFAFKTALIRQIIRIEHAVAHNGVNKMMDLIVQKYYGILKAYIKEYVKDCEACCRFNFLKTNQPIYINYITKKYDFFMMDRVDLRRYSDQNDQYSWILNVIDTYRKHLWCFKLINKTSELFKNTPLKALSTDLNIKFIHGRQRKLKAQTKKLHETGGRREMEHLNNIFNAYNRTIHGFNNPLSRSIIVEYEASMIVPAIDVDSDMVLAEENAEKTQWSLEIASDVHEEFTETHTTITTIIADDLGNDSKIRSDKATIQIYSRKICLLEINFDKEDFDMNTKTKRAPFDSFYDNSVFTVTAILMNSMIEVKNNDGNTRTVFSGVTKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX1</accession>
    <name>A0A4Q9LQX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1742p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001742">
        <property type="protein sequence ID" value="TBU10466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1742p0030"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="446" mass="51160" checksum="14DA03DD3444DFDE" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDILPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKSITEAAYIMQAAQICYDEATQKNIESKISKLVLSKDLLEKARKQEKLTTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR98</accession>
    <name>A0A4Q9LR98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1383p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001383">
        <property type="protein sequence ID" value="TBU11103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1383p0010"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="7889" checksum="20A3BD9B8502A358" modified="2019-07-31" version="1">MKHLNIVVCVYNRTIHGATNKSSFMLFFGQPGFNNPLPRSIIVENEASMIVPAIDIDPDMILVEENAADTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW5</accession>
    <name>A0A4Q9LRW5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA topoisomerase 2</fullName>
            <ecNumber evidence="12">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1909p0010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="PITK01001909">
        <property type="protein sequence ID" value="TBU10250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1909p0010"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="447"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="300"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="641"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="742"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="983"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1052"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="987"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1021"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1128"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1165"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1178"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU10250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1216" mass="134764" checksum="F5F3D61C9D721A31" modified="2019-07-31" version="1">MLSDDQFQNVSFVNGICTTKGGTHVNHVLEQIIEPIIEQIKKKDKSLEIKPFQVKSNIFIFINCSIENPTFDSQTKECLTLRMSSFGSKCYPITEFIKNIIKNSNILERVSIYAKAKQNVQMKKSDGNKSVRLNGIPKLDDANLAGTKQSNKCTLILTEGDSAKALAVAGLSVVGRDLYGVFPLRGKLLNVREANCKQIMDNLEISNIKKILGLQHNKVYLNTESLRYGHVMIMTDQDHDGSHIKGLIINFLDVFYPSLLKIEGFLQEFITPIVRVTFKNKSVLDFFTIPEYESWVRGVGDSSNNTNNNTSNNTNNLTSNNTTNNNTTNTTNNNTTTNNTTNTTNNNTNTNYSVKYYKGLGTSTSLDAKMYFSNLSKHVKNFKSLTSIDSELIDLAFNKKKADNRKIWLKNLITGTYLDNSFTKISISDFVNKELILFSMADNIRSIPNMIDGLKPGQRKVLFSCFKRNLQQEIKVAQLAGYVSEHSAYHHGEQSLCSTIINLAHDFVGSNNINLLMPNGQFGTRILGGKDAASSRYIYTCLNPLTRFLFINLDDPLLIYNIEDNQSIEPTYYVPIIPLILVNGTEGIGTGWSTQIPNYSVRDVVSNVLNVIEGRGVTDMTPWYRGFKGSIEEEVVGSRLDISNNSNNNSNNNSTNNNSNNNSNNNTTTPPNNNTTPPIRYRVSGCYTQSDTSIDITELPLGVWTQPYKEYLESLVTEGVVKDFKEYHTEKTVYFSITDSSIMSSSRGVSSSRGVSSNVKSNKSNTSSNKSNTSGNKSNTSGNTSNKSNNKTTSNKSNNNPYTNNPYTNNTNNNNNNPTVLKKLKLISNISTNNMVCFDYKGNIKKYENVKDILLEFCSVRLNLYVKRKEYLLKVLIKELIKVSNKVRFIKEVINGSIVICKRSREEVVNELKCKGYVGIIGDKIVGLGDNVVGELGVGDIGVGDDIVGLGDNVVGELGVGDIGVGDDIGVGDDIGVGDDIVGVGSTKDRDGNTSNNKDRDITSNTNTSTSTSNNKDRDITSNNNTNNTPTNNNTNTLNPDAFDYLLGMQLLSLTVERVDKLEKEYKNKKKEYEELLSKSHKELWKEDIYRFMCEYDKVCNEEDRMYEDECRNRRGGNRCGGSKGGSKGRDGVSKGSRDGVGRDSGGKDSGGKGSGGKGSRDGVSKGSTKNTSTKSKTSSDKDILSSDEGVKKRKISGKKEKPWEKYNVILSDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA0</accession>
    <name>A0A4Q9LSA0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1203p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001203">
        <property type="protein sequence ID" value="TBU11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1203p0020"/>
    <dbReference type="OrthoDB" id="74246at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="15389" checksum="FACE64F91E76C77B" modified="2019-07-31" version="1">MKKISSTVKPTLTDKNKMDRLKFCLYKVNLANNGDLLFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEEKPERNCKSKPFITKIMFMAAVARPRYDAHRKLYFDGKIGIWLFVYQEPAQKNSKNRAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB9</accession>
    <name>A0A4Q9LSB9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1433p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="PITK01001433">
        <property type="protein sequence ID" value="TBU11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1433p0020"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="22640" checksum="733727CF236C4F1C" modified="2019-07-31" version="1">MFTYIKVYNLTGVLVCCGALVLTVLYYWTKKIDFLLYLVFCQCFFILEILNIKMGKSNSTILPTFLQLLSRIFIIGIICYLNKLYNKMLILMCVCWYISDLIRYLFYLTRNSFIRKVRYNAFIVLYPIGTSIEIYLCNGIYLKYSNSFISYLMGGIIMCYVPGFIFLYYHMIRQRISYSKNEKRGKRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ2</accession>
    <name>A0A4Q9LSJ2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1149p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001149">
        <property type="protein sequence ID" value="TBU11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1149p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF3">
        <property type="entry name" value="OS09G0267800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="92546" checksum="08B6A5ED39A0B5F9" modified="2019-07-31" version="1">MFTSGKNNPNLNIKLAYILISRLNFCILFESSLAHKFTYSFKRNENFEILFFLEDTKEMNINTALDYKDSIKIFFDINYKFKNEKMHVYTYKKENFICFALFDNFLSPNSSENAFKTGIIECNFELSYFLRICNDIIEIPSKWTNYDFKSFLQILTSFKAIENKRLLEYLQVIIFNNLMQRNNSVSNNRDFELKEVFGSCFFSKIDISIKKLFIIAYLNVLMIESAIKDGNLILMNSVNDYVDSYLFNEHIPYGNILVNDFKIFCALETVLENAYMCDIFHVLLSQINIKSLIFDAYQGFEITDIKFKFNIVSSTVFKSIIISNFKNISLEFLNQLCMYIEEQIEFFTIKESTISQCTLDLFFKKKKLLGLKLNNVTSIENTYLIDEHIHLSSTLKYIDFNSIDISPTWWMNCFQKAKFCKIILTFCTVIAQKNFLDKLYRYKLYQSVLHFEIMFFKYEISSNFCNSLTYFLNLKTLKLRGYQTVYSTEIFLFKAIEGLKGLEFLDVQKFNFYLGSYNFLLRNHEIKVLRLTKNLLYSENRIVCSFNGLESLTELHLVKMNVSRSNLIEIFRIKNLEKLCIKSCTFETNTNENLLDFVSNNIKLLDFDGSRLENIKDINFLSKIKFIEYLNLPGHMLPPGYLSELSFHCNSSLKTLHYEFGTLNSKDLSRIEKLEMLEELNISESKFCESNFYRIGNDCKFFNSLKVLNLWFVEMHIEDLKYLKNFRRLIKLSLSMSGLDLIALQSSLNCISFRDFSTSTSTLAHNPEKIVNFLKEKAINLQLSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL9</accession>
    <name>A0A4Q9LSL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1193p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001193">
        <property type="protein sequence ID" value="TBU11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1193p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="449"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1145" mass="132173" checksum="1171C2BF4AA318E1" modified="2019-07-31" version="1">MGRRKKVDSENIKSEKIKAVNNLENSAGEILMRDVDVAMLSERLLPPPTFHNTTHQPPSSSCKTSPVCLVDTIPSSSANGMTNLNTDALLEGNRLMVLHSILDSVTVVEQEWPRSAILAVQKRFERMPRNGWPATLRYYNEKFSCTLDIDAFKKLAQNEAEREIRQEENGERRRIATYNFLSKLKEISEKDIGKVVVRTRKLPTELVDSKVLDLINRIIGEYADSCVAMTITAIARIIQAAQVCYDEAKRKEKPRSAWKINIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEEKITMYERRKQFRKENRMFEIFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYSIPSVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDDIYNFFIQKLTTLHKYIYDIVKVICLEGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVEKRGLLVENQLGAVRGVQEAKEQIDVKKAYDSIDHAYLTQYIENLNLPDWILKFIKVIISKWKIDISLGPEKIMSKKIERGILQGDSLSPLLFVLCMDPLNRKLNEKYTKVTVQTDAESYSTNHLFSTLSAITDEAKDFLEVNGLEINKEKSATNDKCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVEKLLLRLEPDDFSKLDDAVRAVLVKNKVHLRPGCKERLYLLRTELGRGLHSVELRSEHMLLQLLDYEQQSSRENNNKTHLALIKGFLKVKYRLVEEVTKKSLDEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRRNIRPRNEAVNVFWGADGMCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVICLHHLLLNRYKFKSSKRIRSHSVQKILDNEYAEIRVDTRIKTDVKIWNNRPDIFILDKKKNNITLIEVGITSQDSLKIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEANIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTSPLKEEEREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ9</accession>
    <name>A0A4Q9LSQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1346p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001346">
        <property type="protein sequence ID" value="TBU11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1346p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020213332" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="128" mass="14507" checksum="7567FD47F94D63E0" modified="2019-07-31" version="1">MEIFSILFSILYVLSTIECMGNSGSQPETPTNQEQAVKPEVKPEGTGDQNGQLTSQRYDNNRFERPVQNSKVPRGSYSRRGIDDNFNKKESYLMDLNGDLKYEVFGTRNIANEAALMSRISNNEKPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY8</accession>
    <name>A0A4Q9LSY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1628p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001628">
        <property type="protein sequence ID" value="TBU10650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1628p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="781" mass="94018" checksum="8A04FCA418CD3996" modified="2019-07-31" version="1">MSIFYLKGHLHSLFLCLNIYFLLVYCQNVIFYSIENANIDIDYVENGKIDSFKFEIKSMYILNTFKSVYLLQNQYLKCVYINNSYKYYIPNIVEIPGHENIILNFSALDDEQDNVLTSKIFMGQISYKFLLRFIKYSTEEDAFINALSFMEFINILIVLEILGFKRTKNNNTFLKHLLVSSIMSKNFDFHLSDMFLKLPNSDYDRFQLNLEYLFSVFLKFVFIDKISNYTFLYFKNNSSSKDPLKNLSYRGYIRYKERLGNDNIIFLESHICSHLEKLLKYSWIKNSIICFIRHCNVDLYLIAMKMGKLKPMISNFIDLIKPDSLKKLIITDNVINKPTLKVLIHYEYFPITKFVKIICDLDIEEIHLILRNSQNIKRLIIESKEACYNIFFELKKHAIIHKNLNIKYKCNILIMQCQMNDIFQNLPENLSFYIRKFHISFTHCEFCMMKSLTFFRKVLIKYNTKKKLKKYKNQFYNCINTKDVYISTKQNKPEKIHRKIFKYIFRMEKLESILLENIIIPEILIWHILESKNLISIKLYNSCIPTHFSHDYSILNYILRSITIKESKYTLNDNFFKFLLLFRNLTFLKLYIKDIDSDFEMRNKHCTSRIINTPNDNLIVKLEYLKVNIKEETIIDWSILFAFSNFFDISNLNILILQMHELNEKDAFIISNLRSLKEICLSIYRQKTEIMLKRLTKILENKFIKRIRLDICNLNNYMFEYIYKFKNFDMVFIHFQYFEAYDLNSLHRIRCNYPNSVIFLYEFNRLVSSEVKCFLKEHNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT14</accession>
    <name>A0A4Q9LT14_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1497p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001497">
        <property type="protein sequence ID" value="TBU10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT14"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1497p0030"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="45"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="48308" checksum="08E7C328C5018FE1" modified="2019-07-31" version="1" fragment="single">KIFDIPSFPSSTLYELADYDFYNRINSYVDICSNTIKNYGVGTCGPPGFYGTLDLHLELEKKIAENFGTESSILYSNNFTCINSVITCFCKSKDVIFYYCHSNEAILRGISISKATSVYFNGIEDLNKKIKIFYSKKHRNFLIVEGLCRNTGEIINLQEIIEIKKKYKLRLIVDESLSYPLLSSTGSIGYWNVNIKDVDILMGSLSHVIPLNGGFSASSSYVVEYQRLSAPSYCFSASLPGFFASAALQSFTFYAINTSNLFHKYFLSENYSVISHKDSPLVIITHKNNLTNNSLENELLRIYEIKNKLLKHGVRVGVNQNPFPSLRICVKKGLSSKEVMGVINKVKMACETGVSNKAVDNRVLVIVLNNRVLAIRVVDNRVLGLSKKNFNKNVFFLELNYLKIKINDELNLNEEAKVFKFWNNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK1</accession>
    <name>A0A4Q9LTK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0975p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000975">
        <property type="protein sequence ID" value="TBU11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0975p0020"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="25414" checksum="9A15BD9EA488A6C3" modified="2019-07-31" version="1">MNTMNLEPLINFFFIFFPIVGYLPQIITLQSVFPPLLSTITIIANLLKIFYYKVNKYEKPILYQSFVVIGVHSFLLYFYNKKLSYLEEKIFKHKNLNRIYQKYGLFTLNMILITFIALTLNCFCFINGMENLFIGCGFLSLTFESLVGVIQIVINKVDNKKLPIGIKKQRCGKELFFCWFFGDLSRFVWMIWLKSPVLLVLSVVFQIGIDLALIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL4</accession>
    <name>A0A4Q9LTL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1486p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001486">
        <property type="protein sequence ID" value="TBU10900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1486p0020"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="18764" checksum="5AAB9842E19D250E" modified="2019-07-31" version="1">MRILKCYFCSSNVYPGHGITFVRNDSIPFTFCRSKCSKLFKLKKNPRKIKWTKIYRKINNKELCNDTVQMFEKRQNIPQKCTSTTTTTIKELIPSILHLKNHKENVFIEDRILQAQELDKENCIKFLEKNKHILKNKEPPMKGLRSKQEKRKEELFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ9</accession>
    <name>A0A4Q9LTQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1148p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001148">
        <property type="protein sequence ID" value="TBU11546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1148p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="31765" checksum="1BDD6DD43B28E5BE" modified="2019-07-31" version="1">MYSIFKKLLQTQTLDPPSILLILNTIDICFKSIELEDSNSSFSDILNYKIIATKVQEYASLKHKIDVFSFLLNEENYFKVENSNFKNVNSHQEASKKPDENEFYAINETVELNINERKLSRYYKLIGLICLLYLIKFPERASILSSIESKKLTIFLENILFNPNCSVANIENIDLETNKTEITLLQAEIFDLKNQVSVLQAELEKTKKEYFDNVFCLSNNTNCDNGVLLKLQDEITEFKERLEVENSVILNAWNILAEEAFNSEDCFIDKSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS0</accession>
    <name>A0A4Q9LTS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1143p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001143">
        <property type="protein sequence ID" value="TBU11556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1143p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="29133" checksum="9914C5CE24F613C9" modified="2019-07-31" version="1" fragment="single">DLFYCKEINELKIIRYDINIDLICKILFESLFLHGDEFYSILYLKNINNFFSTRLFKKLSIISECPEEPFKEFKFLVNNTEQLYFGRNYPEGSLKNIFFKANLNKLKILSIHDFHIGKKDTNTFKNLDFLISLNILGCNFLDITLAGLFSDEKEYMIENLILRGAYLEQKDIYFLSKLRMLKSLTLSACEYENEAHTYLKIIYFKRLNFIFIDCFLSDAPRNIIDYFIEEFSPNILSLKVEKSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT5</accession>
    <name>A0A4Q9LTT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1448p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001448">
        <property type="protein sequence ID" value="TBU10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1448p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="14948" checksum="C096458F3A5AB468" modified="2019-07-31" version="1" fragment="single">MQNSGLDTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU0</accession>
    <name>A0A4Q9LTU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0920p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000920">
        <property type="protein sequence ID" value="TBU12048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0920p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="123" mass="14090" checksum="84FCEA24F6E0C162" modified="2019-07-31" version="1" fragment="single">SHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV2</accession>
    <name>A0A4Q9LTV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0967p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000967">
        <property type="protein sequence ID" value="TBU11944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0967p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="11609" checksum="882337042E408FAE" modified="2019-07-31" version="1">MSKFGILDQIYLFYTREAGITSHYSLQIIEIEELRNYGLLPNELGLIYKCKIPMNVEAYIQTIVHKKKSKCSYDKGENGLNIRDNDKAIKEMKYFLSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU20</accession>
    <name>A0A4Q9LU20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1028p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001028">
        <property type="protein sequence ID" value="TBU11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU20"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1028p0010"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="798" mass="95267" checksum="E8BAF9B2F473F645" modified="2019-07-31" version="1" fragment="single">MRENKKDKITHKKIKKKNKSEIQNLLSEANIFYVKNKLNECIGLLKEIIKKSPQYFQAYYTLGLVYEEKNELENAFNCFYIAAHIKKKDYVLWKKLYEYTFILHDFYIKNDEYNKVEDKFITNERISDTHGFKSNPGLEITSTDRISEIYKERIYFISILQKKYNSPNKIKEKIDLYEILSMKDKILETKLEYIYFYGSGDIKTEGIYEKNSFIDDNFPESNSSENEEFSASNDLNTEFEYNSETNDKIENVSNETNTDFKEELIDQCLLLKEIRNTIKSNSELIRIIRKAIYFTCKCKNKKSISIEFLNSLISFSYELRDFKSLKNAFNNFAPINVKNIFIFFITFISLNRNPKCYFYEKTENINTSNSTMTNYLGNESATFKLENMEDNITNNNYDANRELKNSLDLFFFEKLMTFKESKDFLGFSNFYIIFDLIDTLFKNKNYTLSYEILEVLLQNNFTSHQINIKLEILNRMAGISISRNLKDDGIKFYLEILEILKNKKYFEIYNLKKEFSNEKLEVECFKMANGETKDPHDFNFSFINPMFPFIFNQDRIKAIVSNLYEELGNRDLALQYSLDINDEIGHFVDDLDQSNHEKKNEFSSSECKKIRSLFHKISFFYIENPNDDLERTLMFINTSNQLISDFMNNSYILNPKKYILQQSLGKVYDSNFEKSRLKSLHGLNVDEWFEVMKMNILCHLKLKKYEDSMNLLNRCLKSGVFKQRSDIYIQFLFLGFKYSLLNNNYGDFVNFVKKIVFYYQNASFYFFMYFFSNFFADYNRDKNFGHCQKNLQRLCKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU49</accession>
    <name>A0A4Q9LU49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0870p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000870">
        <property type="protein sequence ID" value="TBU12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0870p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="27182" checksum="3A07FEDB119484AF" modified="2019-07-31" version="1">MKERLYLSRTELGRGLHSVELQSEHMLLQLLDYLEKIENNNENHLAPIKGFLKVEYRRHNEVVSCLPLLLQNRYKFLSSKRIRCHLVQEILDNESAEIRVDIRIKTDPRKYDLLDNEPNNSLLMSWDGIVKKYYKRYVKRLQIFMNVEAYIQSRVLKKKVETISFDRRRRLDGARASLSVILGTEMHKQPKPFLKQVDNEEFSEPSINANEELELKEEIEVVGMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU67</accession>
    <name>A0A4Q9LU67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1276p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001276">
        <property type="protein sequence ID" value="TBU11301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1276p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="20935" checksum="5D8D22ED3D367DE6" modified="2019-07-31" version="1" fragment="single">KITRIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIILYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDVVRNFKPKNKAPFISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA9</accession>
    <name>A0A4Q9LUA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0840p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000840">
        <property type="protein sequence ID" value="TBU12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0840p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="8982" checksum="4F9CD1EC087BEBAA" modified="2019-07-31" version="1">MSLASQYELPQTLANSPFAQLKPFKGLIDKIPTNQGIIEAEVVDSGVLDVLPATTDALSEKERNIKCIGTAKDILICLKNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR7</accession>
    <name>A0A4Q9LUR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0803p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000803">
        <property type="protein sequence ID" value="TBU12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0803p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="264" mass="30788" checksum="0F1B5F545EE4CBDA" modified="2019-07-31" version="1">MSFWNTKAFRISAIVVAALLTIFLIIGSIGYSKAGKFIKEFEEDFKRISETDQFKTRITKLKQTNSVLLMMHEVFKFIWILDINKNDKTREKFIEAIKTKDSFKIFECLAELDRNKVVEAMDLSCLLAFDPEKISKLKPKFGFFATIGFLFRKRHPMKDIYKISEKIGIKLKDCEKSALILILFLDILDDKKIEISEFDYDKIKHNFDFSSDTFILNPLKRNDKTYISADFIIYLAEKAATDSEAIIEELKQNLILAIKENMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV2</accession>
    <name>A0A4Q9LUV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1228p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001228">
        <property type="protein sequence ID" value="TBU11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1228p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="307" mass="36013" checksum="6978F15F69762961" modified="2019-07-31" version="1" fragment="single">AAILKVENNNEPHLALIKGFLKVKYRLVEEVSKKSLEEAQLAKLYNEIEKRKHHSKLCNARKNELVSVSNSSRWPRNGTVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLLLFLLNRYKFKSLKRIRSHSVQETLNNEYVEIKVDTRIKTDVKIQCNEPEIYILDNRRNKITHIEVYSLLANDLGFIYKCCVEIIPYEMTWDGIVTKYHKSQLKKLEIPLNMEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPTPFKRREERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV5</accession>
    <name>A0A4Q9LUV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1150p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001150">
        <property type="protein sequence ID" value="TBU11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1150p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020812814" evidence="1">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="502" mass="59822" checksum="416206FF31C953C1" modified="2019-07-31" version="1">MNLLFLSLILLFCLSKASNLANPLDIDTSGTRNAMNNCKESNKSKDIETEECLNVILSNIPFFTISFVLFCAPKFGNFYNFFSEFFLRKYNALLNDFYCFTAFTEYDLYYSTTKSILRYFRRWIINEAIDSKVFDGNENNILNEILMKDDIFEKYLEEVVQEKREILKWLENMQIFYYKEDYLEILRNSLHCIEFSRFIRTESLLIFKEIFILLFVINNSSISILSQECPPECNDFKVKENYFINILRRSYNRNKWKSLKIFQKREICERIDSNTLILITGLDVMCKIFSDKMDPNNLNKNTFSRICYLKGTVYPTLFRSNEIKMYLPHEYDQNFIEYLQKFLSKSESKIIFVTLFFSYTDFIVACFLKEILSKFGEKEFYDFFTSDAVKTNEYMKNKAFNDTIHEISTKTSIYEEITTYFIHLSQSMKTQLFLKVSIIKNEEINFLKIYDDILPSISSWNLRNNIRNDVFNSKMTTVFLYSLRCCIKQSIKRIRVPQCSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW4</accession>
    <name>A0A4Q9LUW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0878p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000878">
        <property type="protein sequence ID" value="TBU12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0878p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12659" checksum="21BE0720BE9BA2EC" modified="2019-07-31" version="1">MTQIYSEKQKVCVNTATLHEILDKKYAEIRVNTEAKNNVKKYNLFANESGLIYKCTVDGIVSKYNQMYAKRLQIPINQMPKRVGKERYKCDNLDDSEPSMNTKEESDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV22</accession>
    <name>A0A4Q9LV22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF572 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0724p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000724">
        <property type="protein sequence ID" value="TBU12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV22"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0724p0020"/>
    <dbReference type="OrthoDB" id="2190313at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="24357" checksum="7872B3604DA45814" modified="2019-07-31" version="1">MQKKREKRIGTKYFEKKYSGIRFALPFTIGCITCKEYISKGYKFNAVKEKVVGETYLGVEIYRFHIKCTNCRCEMTLKTDPKNGEYIVEFGCLKVNEIFEKTKKNLEFEKNYKEKEEREDPTKILENQIKEAFQERSGIYQNDDITRAIKISQKTNIDELIEFSKNKEKENELKKEAFKNKMIDFLKNTKKVKKKRFLNIFINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV75</accession>
    <name>A0A4Q9LV75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1181p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001181">
        <property type="protein sequence ID" value="TBU11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV75"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1181p0030"/>
    <dbReference type="OrthoDB" id="112314at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="350" mass="39874" checksum="3AC50FA156375AE1" modified="2019-07-31" version="1">MRGESAYLSVTAARSRNISVVAAMNKYGMIYYKIHERAVNGEDFKLFIKEINESCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVFSVWKNKVIRGGARTEPRLRILIYEKFNEITGEHCSSFYRKMLGYLQKAEVGQMILDLSFAINIPKSTLFDIFKISSTVKPTLTDKNKIDRLKFCLSKVNPANNEDLLFDNLYDYNRAKGTMITKNVESVTAKTIYVQQDNARPHLSDNDVDIVAFGSADNWNIKFKAQPANSPDLNVLDLGFFNSIQSLQHEASPHTIDELINCVQDAFYQLKANTLDNVFTTLEACMESIMLADGGNGYKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB4</accession>
    <name>A0A4Q9LVB4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1063p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001063">
        <property type="protein sequence ID" value="TBU11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1063p0050"/>
    <dbReference type="OrthoDB" id="2193331at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="3">
        <location>
            <begin position="434"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="583" mass="63527" checksum="8290A3D25664C656" modified="2019-07-31" version="1">MNSNPFGSNSEEEKKKQNAFFQNNQQNSFPFNLQQGFTGQQQTNASSVNPMDVQTQGSVEDKRVSFANPLAQNTYQSPFTQSGSSSSSNPFQSQSSNIFGGSNTGNPFNQTSSPLSQTNLGGSSVTSNAFSGQGSLFSQNSGQTPFGQSSNSAFGSFGQTQPVKSSEIQGGTQSGLTSQFGGSNSFFDQKNLSSAFQPPTNLFGQSGSLGQGGTLGQSGTSLQTSTPFGQSGTSLQTSTTLGQSGTLFGQSSTPFGQSGTSITSLPPNELKTTTQSPFGQSNTVSTPAVQNTSSTLFSQQPEISKPPNDIFSSTQPSFLGSQNISAFGGQPSSFSQVATPPSLFPPTQPSTQSSVFPPTQPATQTSTQTSTLTSTPTSNLQSTQPTNQSTQLTNQSTQPTLQSNLQSSQNLDSSFQSQKKEDFSQQSVVTKEIPLFFRQKTVSEVIEELLQTLEKNIKEFHKKAYEIYLYDEKIIKARNNYCKILDTLEREESRILELEENLDFFEKWISDLESNLNLKENTKDELISNIDEIEKLYEDFNKIVSELKDEDDEVMCLINENHNLVKMLDRKVEEFSEFEMSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW17</accession>
    <name>A0A4Q9LW17_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0583p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000583">
        <property type="protein sequence ID" value="TBU12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0583p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25730" checksum="5A9B74CD02A50947" modified="2019-07-31" version="1" fragment="single">FWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHSLLLNRCKSHSVQEILDNEYAEITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYYKSHLKRLEIPMNVEAYIRSIVLKKIGETISFDRGRGLDSGLNAEESWERASMGVIMRSEMHEEPTPLLKGEKRVEDDAKKFKPKNNTPLISEGETQDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW48</accession>
    <name>A0A4Q9LW48_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0925p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000925">
        <property type="protein sequence ID" value="TBU12041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0925p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31414" checksum="68E0D25B153ABBD6" modified="2019-07-31" version="1">MCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVATRIQTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKIGNYDLLANELGLIYKCSVEIIPCVMTWDGIVTTYHNSNLKRLEISMNIEAYMQSIVRKKTFETISFVRRRGLEASMGVIMRSEMHEEPTPPLKEAKREGNEEPNNNINKESDLEEQTKVVKETHLYFQHHYETLNIPTKNINHEHLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW62</accession>
    <name>A0A4Q9LW62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1007p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001007">
        <property type="protein sequence ID" value="TBU11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1007p0010"/>
    <dbReference type="OrthoDB" id="6744471at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="26196" checksum="E08213F38ED23191" modified="2019-07-31" version="1" fragment="single">SHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELDFIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLVSGLNAEESWEGASMSVIMRAEMHEEPTPPLKEGKREEDGAKNFKPKNKALFISQGGTTLEEQTNNINKESDLEEETKVVEVEENIEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG7</accession>
    <name>A0A4Q9LWG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0953p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000953">
        <property type="protein sequence ID" value="TBU11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0953p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="42798" checksum="2B5EF3302273BC59" modified="2019-07-31" version="1">MFYDKVFEFLKNFTFSNLDDIETNLPEYVYNQMERVLAKSVGQKINSEFVESFISKLKYIDSDENAVIITYLFNKYTKILFKILKYFDEYHKARKFLKNGESISLSTTCGINGQITFNKAIFNAEFLEKGYDNLVLLDKLTALICNSSVYLSEKICFNGLNKQANHDQFDLFFDGFDTYNLFELNTAEPTENLKQKFIAFLKSNTIKKFEKVKNDISRTKIYFVLNCNLTLIQFSEIVLNNLDKLRLEPFYDINILNNIKDMDWIKKFLDEPFSSGFVDIMFEDIRRFDCDKIFQTYEVPLDSSGDLGPNQTTMSRDDIMEKFKKASFSIFIFLIRDLLNNNSCYKSAGFSIKAANFSNEWTLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI2</accession>
    <name>A0A4Q9LWI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0650p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000650">
        <property type="protein sequence ID" value="TBU12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0650p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020719594" evidence="1">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="44434" checksum="D2513AF1F363A896" modified="2019-07-31" version="1">MNCRLHLKLFIIFIMLVIKIDSGDTSETNEGKNELCEIFYTECVRYFPDRLYDLLNDINLFTGLSSEKIKGSLSNLNVFGKDEYFINPLKTLKQWNKKKLTMKSNQQEIVKIFDDFAKNQRISQLIFSFFCLYWDCFLSPVNEIYSIEPSRVLELSKRQNRTSEKYNNDEFFKNLELIYKNNERKYSPFFFSNTVSLDAHHEFENTIFSNIRPVKSDSESIVDLNNCNEINFSIILESEYLIAVFICDFIQNIIDESEFSTMFSSENFSKNEQLALKEIYEKIESIDELKPFKSEISGSLTHYLNIFKKDAHLVFAFQSLNSVVSVFTKQHIRDKVFGNQKIYKILFDLYKKYLKRSAENSKKIKCVKSIDYMDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI4</accession>
    <name>A0A4Q9LWI4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0676p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="PITK01000676">
        <property type="protein sequence ID" value="TBU12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0676p0010"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="236"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="729" mass="83446" checksum="14FA55A2036DC6B2" modified="2019-07-31" version="1">MNIKDLSLHKPIKRALKENKIENLTEIQQLTIPAAMSGKDILGISKTGSGKTLCFVIPLLQRLVDNKWCMEDGLGGLIITPTRELAVQIFNVLKKIGKNCYLSCGLIIGGIESKGEKEVIGKMNILVCTPGRLLHHILETPYFDISNVQILVIDETDKLLEMGFKKDILEIMSYLPVKRQNIFLSATPKSINQKNLFIDFDSIEIFSAYKNENTNENKKVKNNLEHFFYVLSICDKVEYLYTILKNNNSKKIIVFFSTCKEAKFYFLVFSKLKMRCKFYLLNGSIKQEKRMEVYDSFKREKSGILFCTDVVSRGLDFPGVDVVIQYDCPERVETYVHRAGRTGRFDKEGISILFLLESEKGIIQDINKGKWKEGSKERGTEGKKGNLGEECVSEGKKGSVSGCKEGNVSERSVSEDRKGSVSGCKEGNVSERSVIEGKKGSVSEGKKGSVSEGKEGNVSERSVSEGKKGSVSGCKEGNVSERSVIEGKKGSVSEGKKGSLSEGKEVKSKKNKEYSNDKIIYEGKKLEIKKIQNQIKSLIAEHEEIKIFAEKYIKTFYRFIEMNSKKYLEGTKEQICKLKEYFGFEDFSDESEEEFENIRNTKESDNKREDNKGDRECSKEKHKGNIIRQDDKENEERENSKENYKRDMERENIYKRNKKSQIINNSKRNEEFKNIEYLNSDRKINKKRLVGKVKNTKIIFDENGNEEEFYRDEITKKEIEEGLEKKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ8</accession>
    <name>A0A4Q9LWQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1348p0030</name>
        <name evidence="7" type="ORF">CWI38_0904p0030</name>
        <name evidence="6" type="ORF">CWI38_2040p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001348">
        <property type="protein sequence ID" value="TBT99428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002040">
        <property type="protein sequence ID" value="TBU10080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000904">
        <property type="protein sequence ID" value="TBU12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1348p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0904p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2040p0010"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT99428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="275" mass="31809" checksum="B000ECFDBBA74B35" modified="2019-07-31" version="1">MDFIKVNNCNEEWYESENLWTPFPGSAVFGGQIVAQALNSALRTLNKDFRPHSLHIYFHKPGINSKVIKYEIEDLRSGKTLVSKRITGKQENDTIVTMEASFSKEEISKYEFQSEKFEIYEDRFTELTAYFESVLPKANHSLLLHLSEFKKNFDIFIGEPKNNKRQIKIKIKENFEEYSDISCIMAFVSDFMLIEPALIPLNKNILSPDIAMCASIDHTLYFHSFEKGYSGEFIYLVECLKFHNSKALCIGHLLNSENVLMATAIQEGIIRFKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT4</accession>
    <name>A0A4Q9LWT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0637p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000637">
        <property type="protein sequence ID" value="TBU12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0637p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="18402" checksum="5E244352DE2367BA" modified="2019-07-31" version="1">MDELECHINSLHKESLIPPNEIKEILNLAVMKGLLTQQDITVIPTSPMSSSSLIHYIQLARRNFLYSNNDTLKEFSILQDLRNTTRKIIERNEMSEFTQMAADKTNELKEIVNGYIQYERKFQKTTKVSKVRVFGSFFLLFVIILIFYVFFAIEKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV3</accession>
    <name>A0A4Q9LWV3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0618p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000618">
        <property type="protein sequence ID" value="TBU12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0618p0010"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45025" checksum="F135A65CBF1BBAD0" modified="2019-07-31" version="1">MENILLKGIKQNTKAEKIERIQRYEITGKKLEEIKSFELLNIELQNKLNKSGFIKPLLIQRLVIPYFINKRSIIVNSHTGSGKTLAFLIPILHLKKKSLILVPNSILQEQICSVIEMIKDENLNILKIKNSKDLKSIDNKRYDIIVSTPEILFETENIILLKNIRYLIIDEADLIFSKNNLKNLEKLFSLIDLKKVCLSVFSATINKIVTEISCVFDVTKISVFSLNAINHEFLFCTTNSLKQISLKTRVDEGIPFPCLIFVKKEETAVELSKRFEKSAVFFKNDQKVLDDFRLKKIWILFCSDRLSRGMDFYNVKSVINYNFPKSKTNFIHRIGRVNRNNFCDQKVITLFTKEDFLKLDRVITVLKENKSEIPESVINIATKAKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC6</accession>
    <name>A0A4Q9LXC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0727p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000727">
        <property type="protein sequence ID" value="TBU12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0727p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020461889" evidence="1">
        <location>
            <begin position="16"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="495" mass="57230" checksum="E7827D89F3EF2045" modified="2019-07-31" version="1">MIFLVFWSSIFGSQGAQFNKNSNKLERAYRDKRQVHSHLYKRTVAKISNTDYESSRRNISEQDQSGCLSSANYSLVEAAENSNKSNTNNAPSSKSCLGAFGEIREYFKSLGSKKSDARPKESSLPPIQFSEDVVSKPIVSYKDVSQSDLPRIENFLNNHYFLAEFFKNNTEINYKKFIKNICCIEQKLMETQPGFSDSNQEIFERELEGIKSMFSPTCGILAKATFLISLKRFVLERLKSIDVSKKCYISFFLAIKSIESILLLTDMRLRNDKIKSMRIDHTFSLKDRINNVLDNNLNLIVEIIIVVCSFGLNMEDDFLKILNILNIGIRNWGFGSIDSKFNSPEISGTDFITDLVFSFDTNEIKKITNTYNSTETMSKDCLATATPLLSLINSCELEKILNEKEIVIQVIKYYLSIFSDSVLPFFNTEEKAELEKEQYISLETQFRKIISREDQNSEIFFQDLRKLRFETYHLFHSVFNHCYNRLLHDSEDQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE6</accession>
    <name>A0A4Q9LXE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0424p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000424">
        <property type="protein sequence ID" value="TBU13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0424p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12840" checksum="21B2CFC5FF9CEDCB" modified="2019-07-31" version="1">MFTCIIDCENMHYTSVIRNDSNFVFPKELTTSFIKFSNSYLRRFSDRILYLSLYLKIDDWIVVFIDQIFLNLKEKGFIYFLEQDLSDIETNRQKQLDEIFRKQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE9</accession>
    <name>A0A4Q9LXE9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0561p0050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0050"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="10">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20072" checksum="3E32B0B3571C0388" modified="2019-07-31" version="1">MSGRGKGGKGLGKGAAKRHRKQAPQSDKISKPSLRRLARRGGVKRLGASVYADMNTLARLYLDEVLRSAVTYANHAKRKTVVCSDVLYALKRQGRFQNQTNFQEEKIIPEEYEINKEKRKGMYINTNKMLDKLYTDELTECEMYLFFARSERSFLNLDEEIGSIDDEIKIITNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG0</accession>
    <name>A0A4Q9LXG0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0449p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000449">
        <property type="protein sequence ID" value="TBU13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0449p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="52467" checksum="2FC93D99BC6FC167" modified="2019-07-31" version="1">MTEEVKKFMNNIGLEINKEKSATNDPCCEDTATLLEGIGVYKYLGIIEDSRGIPTSKSFEEVQTKPIARVERLCCTRLNSRNIFQAINQPAISLLNYHISVHRLEPADFSNVSENKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENNNKTHLSLIKNFLKIKTGLEEELYIFRNNELVSVNDSLRWLKKGLVRPREEAGADGMCLHCNKSGKTVDHRATRCEKKLCNDYTGRHNEVIRVDTRIKTDVKIRYKRQNRITLIKVGITSQDSLKVVETEKLRKYDLLANDLGLIYKSSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNIEASIRSILLKKTVQTISFDRRRGLDWESSSLSVILGAEMHRQPIPPLKQVDNEEDVLKRKIQKIFYPLFWDGITTAKEPKTNANEESEERKKWLKWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP8</accession>
    <name>A0A4Q9LXP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0388p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000388">
        <property type="protein sequence ID" value="TBU13579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0388p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="780" mass="93148" checksum="0BE3DA42C758950C" modified="2019-07-31" version="1">MNVYRYMRMNMVFNGYIFIWIYIWYKIISFEQINARKFRYRFKRNENSEILFFCCEKMSNEVLNEDYEIFFFADANLESYSEENPIFIYREDNFIQFEVLNSFLVSSASENEARNGMIQCGHELSYFLKLSKDITEIPNNLDNHQFKYMMILLKFLKAVENKNFFEFYQALICQYFFYQNTGARRNEYFDFEKIFNSNFLTRIDFSIKKNIFSTFLNSYMINYEFHNGNLILFENSRKFYDVALFDENIPFKNLLITDFRVFCILENILKDTNTRKIFKLLLNETNIKSLIINSYKGCEIFDRNLHFFILSIHTFKSIVMANFIKFSSFFISKVKAVFELNIEYLSLKNIVVSKSILGLFLKKGGLKGLVLYNVNIMEHYGFTDVYSASNETLHFIDFKNVFIGVNWWNNFFSSANVSKIILLFRSIIAEEYFLQEFKNLNRKMNVVYFKAQFCFRKISKSFIKCLNNFEHLKTLKLKGNLTVEKDKLYLCQVIENMKKLKYLEICQLSYEFESFSLLLKFSKIKALHLENIFFDNDTLLVSLFENNRFLIKLVLKKITISQLCLEEIFKLENLKILKLQFCTIKPNINCANINFNSKNINYLNFDGTSLEEIKNFIIFSQLDSLEYIYLWKCNYLLVNLSMFSFLCNLKLKIISYEYNDLYLNDLNRIKKIEVLEELILCGCKFNDCSFCNLGNDCGFFNSLVNLNLSFVRIKIEDLIYLKNFKNLTKISIELDDLNLNIAKFIFVSLPIIQIVTNFVTEDINYNEICRYLNEKNIEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXS6</accession>
    <name>A0A4Q9LXS6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0663p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000663">
        <property type="protein sequence ID" value="TBU12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0663p0010"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="176"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="28621" checksum="726B79DF0D129EF2" modified="2019-07-31" version="1">MKRIDLRNPNKNVQKKNQTLMKLLDEQPNLFSISPVHVLVISLIFIGTVFLLHLYARFGGKSGGMQLFISFCVFVGSVGNSEAKCMCVFYDASKIIKEFEKDFKEIAETDIFEKIVDKINASNSALFDIGDYINDFSIFKFNSENITYGRFFEIMEKKKQKESMSKIIQPLQAIYYFLTNSIKVQIYEKERPKVFYNGIIIGFDEYMNVVLDSEDGKRMLIKGDVICAIVPEKGQDSIINENEIEATEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX7</accession>
    <name>A0A4Q9LXX7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0364p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000364">
        <property type="protein sequence ID" value="TBU13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0364p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26710" checksum="EBA873D078A9A353" modified="2019-07-31" version="1">MSRNKYNTCHCFKKILVEEVTKKSLEEAQLAKLYNEIEKRKLYSKLYNARKKELVSVSDSSRWLKRGNTRPRNEAVFCYIQNRNVFWGADGRCQHCKKSGKTVDHLATLCEKMLGHDYTRRHNEVVRCLHLLLLNRYMFKSSKEIRSHSVQEILDNEYAEIRVDTRIKTDFKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKNDLLANELGLIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY4</accession>
    <name>A0A4Q9LXY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0703p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000703">
        <property type="protein sequence ID" value="TBU12590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0703p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020439434" evidence="2">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="358" mass="40926" checksum="31EAD4649D96C4AC" modified="2019-07-31" version="1">MIFKESGFIHIFYFLLLLFDVLVCTDEEKNKKSISNDTPVEARISGHKKDVSNDTIRFKNNEGSNEHLSIPYKCKKMIEDSKRIVKKKFNNFSEKIKQNFSSKNKKKHKKVSYEIKIEPLLSPTANFYGDNDTETPSSNKPQTPKGILKEPNLEYKNQKKVRFVDDLGTNESEIISSKLTPTYIENSIQNRNTPQENRKSFCPNCKYCKKCIDAAQYDIYSPQDRDKDQHNIHGKQHAPSLPPNQHRGLSSAQNESSNPLIYQEDVYMPIYAQDRRFPRPFSNAPESLGTFQALEKKDYPPNYINQNTIQRPSHPPPPPPPQKQPTQEGSLSSFNQTSKIISPPPPPPPPPPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ8</accession>
    <name>A0A4Q9LYQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0299p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000299">
        <property type="protein sequence ID" value="TBU16186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0299p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10432" checksum="8D8BE1F7E32C00C1" modified="2019-07-31" version="1">MIYVRPLTVLLEKTIQQTLKDFHADECEYIRLADITLKTLRWLYMVVLEDEIQEEPTPSQRQANSEEDDVTRKHKKLTYILFYTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ38</accession>
    <name>A0A4Q9LZ38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0247p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000247">
        <property type="protein sequence ID" value="TBU18240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0247p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020216742" evidence="1">
        <location>
            <begin position="25"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="51145" checksum="970E44A093648C09" modified="2019-07-31" version="1">MVGGYISLFLLISAILCTKNPAKTKKWYKNDLLSIIHNEIYKQYRENTTIYDKICSYEYLLLENHKYFESEATDEILKFILAKKTEEFHIIFALIKSNKISSGFVFHVSIAIYDNFCIGIKFMNAYYEIPIKSIFSKIHSPSIKPHIKEYYIKKHISKFIFHQIVIFKRLINKIISNRKSIFSVPIFSDIIFFKNTDHDFISRILLRQEYIYENDYYLLINNLKINRRHNEFNETDNLNNILKYSFTNTIFKSIRNISFKRVEISDISKKNLPHKNYKNQIIAKEIYICNQIKYLNIYDIFLSNFQDDYEIEDRNNEYTNILGYGSANIDIVTFSKIDKPEKIKKSLQEYCYLIIRDRQINLEYHFEFTYKRYNNEIINISLNPTIPSFSADITLKNKISFILNFVKEYRKSNFSLVIWNQTESILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ59</accession>
    <name>A0A4Q9LZ59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0534p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000534">
        <property type="protein sequence ID" value="TBU13090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0534p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="777" mass="90107" checksum="1EA5B3165F415D43" modified="2019-07-31" version="1">MNSMNDVINNVSEKILLPKTMSMKVLLLLLIVQNCVDIKLFYVDSRDDLDQGLENTIIINSLLSNTTIFVKDENKSYQMSEFISYINAKHQSKAIHHFTVQYSSNSNFTVGLFERNREINTIFLGNFFEQQVKLFNLLLNDSNFLLYETLGENTFLDFLRLSKIFGIKDDKKFESCLKELIQYYNRELKDEYFQNLMINFQTFQQEVDNWVILKSFNILGCSLYKNFSIHSTSPSETFEGEILDKNTLFSNIGNNVNIILSPTFANTWKSFYPSFCKHALLNFLLKLVNVDIIEIKDFLENNILDFGFFMPLMPQNAVVLYINDSSTDRILDILCILSFLDTIRILKIKDKTLNTSSVSKFYKFRNLKNMIIEVETLQHSALYSILDVAKCMKIESLNIKCENVLKDLNNCSLWIPIETPCYYFSIGKYINSKNEAFRSMIVKSYGNVITSTSVEIFNSEAEDLINFLSLFPNLNELFILNRGPIKGSEDLSLKFLEEHKIKSLKLQNFVIDSRLLDKILNTSILQNLTLIECQIQIDGDLFPNPYICNNSLDTLNIFDSSFTPSLFYNNFVYKLKNLKKFDYSGKYMIFNIISQDSKLGGEIVNSDISLRFSNQEKSGLSNLDPNNLEFSLVALYFKNSSFPTFTLKDVELNLDEVLAFKSMNNIVNLTLNKIKSTESIHLVADILQNRDLSRNIKSLCLINMDLDLNDVKSLNFLSLLENLKLINIYKDDSKCYFWAIKRCHLRKLKEINIIGEISKNNVNYLKEEFPLRMLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB6</accession>
    <name>A0A4Q9LZB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0375p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000375">
        <property type="protein sequence ID" value="TBU13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0375p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="603" mass="70243" checksum="68DCC53E62E4D306" modified="2019-07-31" version="1">MKSFNNAAVPKRNRLIVLHSILDSHRSVILAVKKRFKKTLRNGWSAFLKYYNRKFRRTVNNFVLKKSTQNEAENEIKQEEFGDRRRISTYCTEQFSLTVTTLCINPIEKFICEMKKISETEIRDVGVLTRKFLMNWCKTFTDASRIIQAAQAYHDMLPHAETTMIYGTPQADSFIYRLAYLIIYGISRRGSDYSSITCMFNLYMLITGWVAKIIQLEIIGENSWECKRSESVDLGTISLYKEYENNLKATYIDSDSRSLLLFALYMDSLCRNINEKYTKVTIHDHADSHTTNPLLFIDALNKIIFNRYLIRNSQREVRHKIAYWKDTATLLDFKDFVPLDQTQKMYFLQIIKIQYHVSNDAMRAAMGKDMIQLSFTCVELRSKQMLLQLLDCLERKILKMKNTNKTHLELIKSSGKCSIEKRKLHSKLYNARINELVSVSGSSRWLKKEIIKQIDDMCQYLNKSADDVDHLATRYEKILYHDYTSVIMKSKTVEEILENEACGDESAYQRLESGLNAEGSEERAAMGSVNINEESDKEKTVGHNQLSKSRTITKTDYRVTKYISSKIQQIVKDLFFRRASHVSWPGIPRVKSSFSFNLLMSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB9</accession>
    <name>A0A4Q9LZB9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0530p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000530">
        <property type="protein sequence ID" value="TBU13105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0530p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="91815" checksum="CF0CF271321F6434" modified="2019-07-31" version="1">MKWVFYILYEFFAQIETKIKTKVIEFNIMYAKDSDHILCENTGRNSSILSYQYGFCSEENNTLKICKGLHFFSRHRFICPNRNGNKKHFKLTTIMISFPNNICLKPSPNRLFLISKVPKRIYLHQNLYSIDFKYCLKTFSDFDYMIANLKIYKFLDLIYFSYIIDIYKDKNFYKILKSYMIHIPGNILYHGINQVILYKERFDSTYFEWIISRMLDAYFEVNFFCVKNIKNLKGIFDKKAIEEDQKLKITGKILKKMHDYILRGNEWTKLYFLFHFKNITSIYLNDLHLVDTKKISCFNKLFSNPIYSIVIGYTDKIGLILLNLRRIKVFKEIKKLEIQNSFLTKNNLRLLDWFTALEHLVLLDISIKHKNLFFPKYLIGKLINLKVLDISVSSMNLRTDFSNYFPNLKKLNLSVEKTIFFNFFDNLIFPSKYYLILRKISICFIYASFKGFSSTIANFKKLEDITLKSQNSTLSFSFLPICIPKYNSILKNLHLDNLYLGYYEFLIIYNFKNLKSLSFKNCTFSFINYINFSSIKFANKLENLAVENCDNAYDIFLTIKLYKNLKILNINSTVWAGFANSIVIENPNLNTICFKCRDLSKIPIKIEGINSKLKILEFSFCNFPANSLHLLELNIDYLKNIKDFTYSDNNLSPNDINCISNMYNCEVLDISRCEFQNCHFHDIFLPNKVYKIKELYIFDLNLNKKDLIALRNLNFLLHLSISLCSIDRSSLYYLKKQYLKKLQSIDTCNCKIPDDIRILIQTEFGWELYPSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG2</accession>
    <name>A0A4Q9LZG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0505p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000505">
        <property type="protein sequence ID" value="TBU13200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0505p0040"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="285" mass="32147" checksum="B5D218045FE41EBA" modified="2019-07-31" version="1" fragment="single">NIQEDIIQSIENFLAQSILDGCEGIMIKTLTTHSTYTPSKRSSNWIKIKKDYLQNISDTLDLVVIGAYYGKGKRTGNFGGFLLASYNDETDCYESVCKIGTGFDEQILSSISYKIRHGLTISSNIGGESDGGRGIEIEEKEIKEIEDRDREDNNNTIKEININDNTNKTNSIINNNNTNNITNNNTNNIALCISKPPPNYIYTHNTQPDIWITPTLVWEVKAAGFTLSPIYKSGQHSNKKGISLRFPRFIRERTDKKPEDSTTSSQIVSMYNLCNNTEENEDTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ3</accession>
    <name>A0A4Q9LZQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0513p0030</name>
        <name evidence="8" type="ORF">CWI38_0478p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000513">
        <property type="protein sequence ID" value="TBU02297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000478">
        <property type="protein sequence ID" value="TBU13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0513p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0478p0040"/>
    <dbReference type="OrthoDB" id="2194933at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="196" mass="23135" checksum="67330E5BF5E8D71B" modified="2019-07-31" version="1">MKIFEITEKEADTLISLLKLNGECEYRFGTSGIYKYKDPLQISMLKKVYSMTSYPSTDTRNSISVLLKIPQRSIQVWFQNTRQAMKEIDYAESKYGIRFDYGAQNDNYIKKTSNSSLFNEKQISIENRYESNECLETTKNTKQSDSEQKFTPEIKSTPSDINSYEIPSKKLVNMFWELNRELIKNKNYKNILFRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ6</accession>
    <name>A0A4Q9LZQ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0436p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000436">
        <property type="protein sequence ID" value="TBU13421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0436p0050"/>
    <dbReference type="OrthoDB" id="2196329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="344" mass="39480" checksum="635094B658DD7169" modified="2019-07-31" version="1" fragment="single">SNPSLNTSLNFRGQKENLIVDSHKTSHSNPSLNTSLNSPSNLNFKNNILIPMTSESNDGVKSDLIMEMTKLMDKIYLKMDEDKKEKEMKDKKRIGDWLDKMSNHFNTTLNSVIENAIRREMKGLSNSLKKTISDSFTNYEKNISSSKNRNKEDNSDIVKGIKEVIIERVLPAMEASVEEMRLQVVGEFKSLNPEDFLRERLGKLRFTESPESQLLRLLNEKKTEAASVMALEGDDSLFDYFIENIDLGMLCSLTSGCLISLLERLIGMNKNNIKPKQADFIKCSFVCLEIPDLTENELKNLEFIVACIEDFISQMVVEDKDLRLILITKKNSLYKRSSRRHRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ8</accession>
    <name>A0A4Q9LZQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0193p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000193">
        <property type="protein sequence ID" value="TBU19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0193p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="16139" checksum="76A78AC0D03C8CE0" modified="2019-07-31" version="1">MNLPLSLNPVSLYSSSNHELFYYSNDSIITESVTDLNLQTKDFKIISVFSIAIVVLFILNLIELSSLTRFHSEKLGILIVFAIFLKIFYLFFAILELKNIKKFLSCKKVSIYKVFTFTLGVFDMGILFGICYFYWQKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW1</accession>
    <name>A0A4Q9LZW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0313p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000313">
        <property type="protein sequence ID" value="TBU15318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0313p0010"/>
    <dbReference type="OrthoDB" id="2190647at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="301" mass="35198" checksum="E2BA32D0A1D42653" modified="2019-07-31" version="1">MNNETFKSDFSISKNTDYITTRSTEDMVSDILPIFENITILSVYKQRCLDLFKILNKTRKCKLFDTPVISPEISIFTPRLFLENIEEAGQSKLLVLDDCHLFIDFGYLDIMKEIKNRGYNFIGCTKLITDMEFMKNPIILTNGFSYFIKCHKNEAFQALFVIFNFKMLKGSVCLVVDPKLIRKFYIFLQVFGVDCCYYKKGNQAVSICSEEEVDSDFKVNNLIIVGKKSVDCQFENIIYLSNQEIEGIRPYNLDYTKIEKYNYRINDVLRSITPSVIKGVKDFDYERFKNIKSVIDYKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX9</accession>
    <name>A0A4Q9LZX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0453p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000453">
        <property type="protein sequence ID" value="TBU13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0453p0010"/>
    <dbReference type="OrthoDB" id="2191972at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="717" mass="83930" checksum="9C579A773D51D052" modified="2019-07-31" version="1">MSIAESFRKFILGNPEFFEFNGDMRATIKYLFLSNNRFFLLIIFCSLVCFFAFFVGIFRRRYFFGNFFLYIVGAILLFTAFCLQRSIDTREILISGKNPESISNEEPKKKNSLFYLVSLFSHDKENDQKMVEGISITKNGEDTTKTMDGKNMDTQINPIFKKEHYLDDNGSKFYDSPTKLIPEVKENTKNSILRGKFVKGITNMFKETGLYSKGHNLLRKNFFSNSKNQNDTNTNSKSTNSTNNTESNMDQKNGNHTIISFDKSLDTKDRKTKYFEKIEKNIEFKRNTDLELYKYKTDLEKRKSETEYDVYLFEKEFENFTKESKKIEKELISIDISLDLYIYEMTEMKNEIYKNFGFLGNEKKIVTKNEIKPKSGNETQSTDESTKSNKIVEYNLKKETLSDLPMNDPDVNPLLGFNSFLSSIKSKMEDYSEKTSKKENNSVDDFYFYMESYLVVQGICVFLIFILTICQFYDLIFIFKIILIIFLIGDIFFGIPTLIYSQVISKDIETKNIPQCKEDFNFKIDGLVALLESNLGVKNSDPSKQVEFIQNQFKSIADYEKKVAANIETFIQSSLDNKSLQKINVFDNLLRKFKFIESDFDTLMDNKVDKNVYYDIIFKLKRYLEKIKNNIFSLEKSKALELYKNVSQLEYFFRTESEDVDVNVQNFIKSEAEEMKKNKQSDCKDVTKKLKSTKEKSDELSFSLLFLSTIFLILILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M028</accession>
    <name>A0A4Q9M028_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting ATPase</fullName>
            <ecNumber evidence="11">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0165p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000165">
        <property type="protein sequence ID" value="TBU19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M028"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M028"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0165p0020"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1112"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="254"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1205" mass="139336" checksum="A3FA0E3FEABD86DC" modified="2019-07-31" version="1">MFFILSPNNKFIPTISMKNVKRKKQEEDFLIIEGRKRRFLKIYFNMLCIISFGVLYFVCRYLKKVRIYIETKACKLSEADVVYIINQFGDIEMSDVKEIHFYGKSNVLANYVRGNIVRCFESQFYRFLFDYTTSKFVIPAFFNTDCFDSSLNRYLKHNIDQTIEELNLNLSVKEIIYGPNETFVKQKTTFEILIENIFSPLFTYIIICVILWINIDYALYAGIIFIISLHSLFCDILRDFKNRKALRELAEKRNFVKVLRGKKRIEIETKYIFPGDLICIEPSKDFFCDAKILKGTIIVDESFLTGEALPICKSETSNNNLIFSGTNILSSSNEKNHDDMDFEFTHNFAKINEDNNFHEVKNDFITIEMYKSFETNSFKQISNSSSENSLYLDKKTNENLYEYLDDYSIGLVISTGFYTTKGKLIRNILLPRPPDFTFYKESMNLIIFVFGMGLLFTFIILLYFFIIGNPVRISLIYSLDLLSCILAPALPTTIWMGANISAARLKRMKIFCSDLERINSAGRTNIVIFDKTGTLTEEGLDVHCIDNFQIAGDDIGKFDRKMINAISTCHSVYELNGECVGDPLDVKMFAFSNSRFCFERSNSAKYRLIEINRSMIDLNTCEKLFYDQKKHKFLDDNERSDSLVYNQISDNLYSQLDFKNTQIENRFYKVKIVKCYDFDNNLRRMSVVVVDNGKHFVYSKGSPESISKILCNIPEDYEKRVREYTLEGYRVLSIAYKETHSININERLRIKDEDGLTFLGFIVFANKLKPVTESVLVELNEAGIKCVMATGDNILTAISVARQSKLVDKYLPIIFPVINENAKNIYDAEWLCVGDEELTFDKIRFCVVNKKNSLPFDDFLVACEGREYEFIKKDNSTYFSFILSKCAIFARMNPDQKKMLVEDFADIDYSTCFCGDGANDCGALKSAEVGIALAQNETTLTSSFTSRITDISSVLTVLKEGRSALVTSISRFKFVFISSFIQYFSLYILSLKFLFLSEWQNMHNDLFIVLPLAFIMTKFKPSDKLYKKRPNHSLISIESLLPLFGTIVIQSIFLIICVLLIDKSEGSKGEFLKCSMGSTAIFFVSSFQNLTSGILYTEGQPHKEPKAKKIPFIIHLVILFAYTITLLLFVMKTIRFEVFDRLFSRYKFIKFDQKTSLVLVILIIANSLLNFYYNIMSQKISGLFSKRNMKRYNKNDKVDDSKEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M074</accession>
    <name>A0A4Q9M074_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E1-E2 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0434p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000434">
        <property type="protein sequence ID" value="TBU13425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M074"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M074"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0434p0010"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF508">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE CTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="11">
        <location>
            <begin position="830"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118046" checksum="72B673E51F4F70F8" modified="2019-07-31" version="1" fragment="single">MNISSEQKNIKSESCDANLVLSHEYDKNIIKSENKSHEISLDHYFSTGQEKKPRKEKIKDSRIKEFIFSALFSPLQDKLSLILLISSLLNFLLAFCQNCTKEDIFEFFNSISVILISSFLEAFQDYKNALFLEKSRLLLAPKTLVLRNKLLNEETYLFKNDIIYLRPGDIVPTESLLIESSIFKETTTTFLSINESAITGESHCIFKKVLKTENFKNLDEIYMHLQKNSNLDTECTSDTFSKPSSHANIKTKSSQNISISKEEEENEINGCLMRAGSFVIHGSSYALVLTDMDNNSISELRQKLEKLHSLKKSSLLLTTKKCGDVLSIFIAFFCIILFIVGTFRSVFEFNVYFKGDRRNIGFYNFFGSIFVELLANFKFCVSLAITAIPEGLELTARLCLSYISQKLQKKGVLIKDSRRIESLSKITTICTDKTGTLTTNEHIVSEIYILKNKKQEIESLKVSNATENSGVFESVDFEKYFEDKMSRMLFKYCNHLIEVDSKPFGDPLELAMADLYSDFESDSSEILHVREEIPVSDSLFSKTESSSSSIIKLPFCPGNMFMKVKITNNDGKEIFIVKGAPENILKNATDIYISNGATTDIINITDTIKNEISDKIKCLSENSFRIIGCCVQIDNKNIFHSLISFIDPPRNTVEESIKWCQNENINIIVITGDSLLTTKSICNEVGIIENSKEVFLSGIEFYNMKEMEFQEILPHLKIIYRAEPKHKLRLISLLKKKGEYVLMCGDGVNDVLAIKASDFGVGMGSGTEICKETSDCIIKDDDFSKIVECIQEGRTGLHNVFCILKYLLSSNLGELILIGLCYFNNIKPCFNSYQLMFINMLTDGLPACFLCFNKKGKCKANYFTIIRGILIGFYIGIGGFLVYKNTLQNIFYNTKVKENPGLALTFILFSEMVNSLNNIDLNESIFLTYQNNFKVVGCVVMCVSILIGAIKHGRICGYMGIENVDVSEALFVLSLSFGVLVIDEIMKLSLILIKITLQESLQIFETGKLLLYDISANWLGLIYKCSVAIIPHAKSKILLQLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C0</accession>
    <name>A0A4Q9M0C0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0268p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000268">
        <property type="protein sequence ID" value="TBU17675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0268p0040"/>
    <dbReference type="OrthoDB" id="10022853at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="816" mass="93933" checksum="FC7416C2819A7EDE" modified="2019-07-31" version="1">MGILQLNNSMYLRSVGVMAAASYETSDNEPTRSSTGEAMMDVDDMNIQIINVIFKRDDSERNIEQKTVMDKNPMFYFQSEQRPLGGLCNGSHEKIHQVADSVENPVTDFQSKFKCSQGNPMKYHTLVESYQFIITKTKSDLKFNFTGHFFYKSFMCFEKLLGLKKDDSLFDVSLDSFTEIMKLLEYLITKPKDSFLSALISNEEPMECDQAEGKNILLEKNDGSKEIPQDLSYSEFAEIVEETLISKGYYEWPLAAYLSIFNLSLQYCNDVLIIQKQANQIFSFDLADKTIGKNFYVRIIKGSFFSLDQACTFQENIDILSFFFKNKNILGLELIDFEHEPMADEKYMRHDAEIIRKPENELQEEINTRGALLKLMNIPAFREIKTLKIKNVDLHGIDVNILFELKNLINLEVTSESEEIKRGIGKIIRENNNLKSILLESVLLSKILFDSLKKVSPEVFVLKNCKPYERNRNTNSETISFLSLFEDSKSKFGPKLLQLEIVGGKNLNPNFFAHLKNLKILKLISCLNENISEERFKNISEIKNLEELTISGNTFYQNFTLKIFKLSISTNHSVGVFKFINCFPTLEVLNLSEYDVNANIYTTNQLSVELPPNLKVLKLEKLGKAFFRKFHITPLKKIESLSLRDSNLITCCDFLRTIDETSPLIKLDLSSCTLNIIDTRKLRIYKTVKHLFIYDTQFQNMNINEFLGELNGFALEEIYISNVDLIIKGVKLISQLNKFPSLKKIFLYSVSIPEKSFDSKLFSIGYDEKNVCKKEIEILESFFNSEILKTFKIDSPLILTNEKKQAPLASAPERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I1</accession>
    <name>A0A4Q9M0I1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0126p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000126">
        <property type="protein sequence ID" value="TBU20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0I1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0126p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="50712" checksum="19255F118B815371" modified="2019-07-31" version="1">MKPECKFFQENRCKFGLLCKLRHLTRTYLVDTPVWILSCFQSLYMFDISIEEVRNRFYDLKMSGQLEIFYEEFNTAWKTNFIEMCRCLIWLSQESDIISYTDRGINILYDLSQIINSYPNLDNFQLNSLVEELKKQPFSSSEIERFNKVGDRTDKRIKEEKILNIFGDKEDSLNKNEKRGDSFVNKGNYRNDYYDRRGSSRNYNKEYNNERRGQGRSYYRDVRGENRGDNYRDNYKDNHRDNYKDNRDNYRDNRDNYKDNRNIRDNRNIRDNRDSYKDHNKGFGRRNDRKSSSFVEFSGNEKKDFVRKKEGRILTSGGNEAYRERNEIYRERNSDGVSGKGDFYRSVGGSENPSLVNSSASVNSTFMQNGFIYERNTPFSQSETNLRGEVMGGEIMGGECEESKEFKKKENEKKFTFGNFPYQPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P6</accession>
    <name>A0A4Q9M0P6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0123p0060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0P6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0060"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="3">
        <location>
            <begin position="174"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="852" mass="96930" checksum="0744C906E2E04FA9" modified="2019-07-31" version="1">MEFINISLFKETCAYCYTDIYDPQGIMVCKCGISVCQTHKNSHLWTEEHMIIYFIFAFKKAMESKESENEELQSKDFKRNNIKNGDNNNEFKDLFVHSTILNPDEIYILEESLKEILSKNKKEDNIPYEDKTKCTHVEEIEWKGSYRLGKKLREEMKEEIEEKNTKNENINEEIEEKNTNNINIKEENTNDNKLFNQQNIITKNDNKCTDCEITTNTWLCLSCGYIGCGRKQYGMSGNGHALNHNINTNHNIFVKIETIKGLGTGDCYCYKCDNYIYNEILENKLKDINFYTFGNYKGTATETDLVGDGTINGKDNICKDNDNHIVNKAHALNTINNNDNTRNTNINTINTELNTRNNNDSTINTNDNTINNNDNTINTGDKDGYLKKYVGIRNTGETCFISAALQMICNAIKYEEIDCEDHFVGCRKNPLKCFGCQFLRLIGGMKSGNKNVIFIDDLINVLRNGDWSTDAMTTCGCDECPRCGTCEGHCVECDPDIEFGKYKKNLSYLSTQLSGLLKGQQDVVEFVEMFMSYLQEYENYNYFPKISKYFRTIVVVESYCRRGNGISSKLEGVSNTDDNTPVKDTIINTENNTPVKDTIINTDINTPVKDTISNTDINTPVKDTILNTDDNTPVKDTILNTDDNTPVKDTILNTDDNTPVKDSQYKCNYKPSIKRENIFIFSFPFKEKVSEGIKECFKESKEKCGCGGVITTRRSIINPALNMLLHVDRVILTDKGVIKVNDGLSVDKYDIGCYYKDISEFGVSNVKDIISTNNDERYPCLNEGEEEKGILKSVGKTNYLWKSSVCHFGEKTLSGHYVWVVGDEEIVVVNDSSVNKGDEDVVGQSFLLCYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U2</accession>
    <name>A0A4Q9M0U2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0375p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000375">
        <property type="protein sequence ID" value="TBU13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0375p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19804" checksum="0367AAC1ADB7BE75" modified="2019-07-31" version="1">MEENRHIEVKVIINNINDRDSISISSNTDGHMEQDLQQMPVTGGIIENFNVICNDRDHGEQYFREIYNLPQSQESSLEDTASQFFIETEANSNTKNVCKFLRKYAMLLYLIIITLTDAVFVVDFTAHHISVSLIPFIFYIFHEKHYKDIQAFIRTSVISYSSVPDLYFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V6</accession>
    <name>A0A4Q9M0V6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0109p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000109">
        <property type="protein sequence ID" value="TBU20225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0109p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="297" mass="35447" checksum="799872B5C50DDB8F" modified="2019-07-31" version="1">MYPTDDTISTEADKNIDEEKEIILPTSVSQGGKKNNQKQQLNQKHIHKISKTTNQISYYSFNNFVGEFFKELSEKKYEEIFFESVIDEDIAFNKLFEESYTCEVKREISLKNRLFSAFITDDSKNDTIYTENDFLKSLNLDFTDTDDLDNLIVELFKQNKIPIYDETEFALNGNEIAKLIVNLRKQVIINNKRKKIFKQILKKRMLFMSFLQALKIIDSKLQKLYLKRNKAKVKSRSNEEYEEIKTLLDIRKHFFELFQDELNYENILFTIDNLFTDHNEQNIKLKDYNPDNYFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W3</accession>
    <name>A0A4Q9M0W3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0097p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0020"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="45577" checksum="326CB4E066FB4943" modified="2019-07-31" version="1">MNKYILMRRAAILKVENDNKPHLALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVSVNDTSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRNHSVQEILDNEYAEIRVDTRIKTDVQIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSIEIIPYVITWDGIVIKYHKTYFKRLQIPINVEAYIQSIVLKKIVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPSLKEVKNEEDSVKQVNSKNILLLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A8</accession>
    <name>A0A4Q9M1A8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0178p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000178">
        <property type="protein sequence ID" value="TBU19897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0178p0030"/>
    <dbReference type="OrthoDB" id="10626132at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16262" checksum="3A21FF54352171DC" modified="2019-07-31" version="1">MPFRNTDIIEGRVLIDICVNKRVLIDICGNKRRVLIDICGNKRVLIDICGNKRVLINVCFNRRVLINVCLNKRRVLINKRGNKRVLINVCGNKRVLRNKRGNKRVLRNISGNKRVLIDSRGNKKVLIILSVNKRVLIITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L8</accession>
    <name>A0A4Q9M1L8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0247p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000247">
        <property type="protein sequence ID" value="TBU18238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0247p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="768" mass="92303" checksum="71156E7559CAE90D" modified="2019-07-31" version="1">MREIILNATYTKNNIHCIIFFILYINRIIFAQKTIAIHFYENIEGSLLENKVNNNKNSNTSSYFSNINYISRNYNLKNKDFKVFIIEYDTFLLKFLNEEEIIEGHQNSIYINKSSISYEDFLYFYNIVMCFPYLIDFMDECKYLKILRIINIFKFKYDKSFEKFIRLILVSLMINIKPTSKLNGLVKANIYSLPGYFAKRIIVQLFKLYLFSKKTLNKIKDISIAMTLTKYYNLDFINLNEDYLYLDNYIIDEILEKYLKIDNFSKIIHIIFSIHHFRSIFMYKISYLSRFNTFFDLCLFNNLDEIFFFECFQTDFLIQKIYTLDIATNPKILTIIHCKFTIKDEISFLRNLKVKILNYDATKHELISIFMNLGVESLFQNFFSRFEIEIYNKENQSWILGRDTNLPCIDWHTEMNIIFYEELNIIEKLKIIEFPFNAFVYIELTNPLISFEFYTINLKDLKNITIIFTDTYIKDFNLLDTDLFSHIIHMRLVRSRITDIFLAKILLFPSLKSLFIHDCSIIFNDREITFSENTKIEKLYYQVSLIENKDYFLKYIFKMIALKNLEISCNLKDKNSLLSKLDCMNSIFINLTQLKYSVKHYFTDSLPKFSIFRNLSEFNFGFEYPEGTVYKIFHDQPFVNLKKLIFNGIKIGKNDYLALEKYTNLTHINFSLSCKIKVISFSEIFDCKLKYSLQELRLPDIEFNYCDFLFFLKLKSLKKVYFYSFRVKIDIIYFLKAFSSVAEIDIEKFLEYKTLIHEEFGLRFSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U3</accession>
    <name>A0A4Q9M1U3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0040p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="369" mass="43945" checksum="9FF68D10C3287CC0" modified="2019-07-31" version="1">MIILFTNSLFTLIIYYRNDVSDFTCGDKNENMMVCSNSKRLKLESVVNENLFLNKKFLMDIKEFKVNFVSNKNYLKQEYNEDFVFLDNVNEKTLNIFYRFIRNPYIPIEILLPNEFIAIIRILEIFDFLIDIRFKNLIRSILYSSFICSDVFIKYILYDFTRSFSGGISSKTLRELFLADFFILSFTDAKYFNKFIKIEKTQYIDIKNNDTSNNVEYLEFVIITLFNCKFYTKIDKERMFCEQLKVIFYICKIQKVKIMNANDFAKYTKNILEITSKSLIEIELQFSVINQEFIDFLSNSNQFIALKKIEFISPKNSFINLAISNLCKNVDTLYINNIDIELKFNNQNEYNYLVEPLYINFESNASICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M297</accession>
    <name>A0A4Q9M297_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0096p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000096">
        <property type="protein sequence ID" value="TBU20287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M297"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0096p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020683914" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="244" mass="29002" checksum="021D28629CD088CE" modified="2019-07-31" version="1">MHIFIHFLLLTFLCFGSTSKSPLNPKTERRTYDSRSLASGSQTKKVYESNPDNIHHLIIMNSYQDVIDSVSFRVPYLKKFIHFYLRKIERLIPEYLKKSLDKQIETLKKRRINSNFTKFTTYEVIFLQLIQNFISDLLSNSMEDDASERGFDQYNERIRNVLKSEVDAMKLAIISDLEKVQNNRNTEGYKNTKKDAIKFVSDLQDNHIFKKIFIQRIFKILEEGFKSFWIENLKSLKFESEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N3</accession>
    <name>A0A4Q9M2N3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative calcium-dependent phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0001p0150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2N3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0150"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="216"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="481"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU21044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="907" mass="105286" checksum="CEFB6DC0273C8F51" modified="2019-07-31" version="1">MEEEDLDIIAQKPKLSSSDSAIKVNLITQIAISVGCLVFFVIVRPKMKWLFTPNTRNKPKHPGYGYDGYFSWVLPILTVDDVKLLSVIGLDCFMMLQSLKMLYRIFLVLIFFTVPTLCFVYWHGNNQEENLNQLFLKLSITNFKKKDIRIWLPVIAVHLTSLVIFYLVYIYYKKFVPLRQAYIRNPATMTSIPTLKRISFDLSSVTDAIEYVNMPARTLLFTRLPSFIEDDDDLAQFVTALGVGEIEDCILVRNTKNLNKYCQAKEVYIREIEREIDYSFRNINDWSADHVEKCEKNISGFDKKNVILTAEHNFSDQVFEDEEKTEIVKKYFAGFKSFKRKHKKNEIALDLNLSKLQKTYQKINDEKIALHDVKKPEDKDVIELMGKKEALFPREDYTRNVSFFSFSHFIHINKHYKYFTLELPVFTKTGFVTFKSKKAANIIAQSLIGSKVFSCTATPAPAPKDIIWAHINMGEVEAYFKNIIGTLVFIILIFAFYTLVFILTGFLHLNKLEQKFPNIKIITKFKTVKESFDGIVTPLIYNALLCLAPIFLTALSYSEGVHCYSLLQYKMMDRYGLFLLFNGFLALMFTSTFFTMFKDLYTGEKQFGEVIEDIGKSLIDSAVFFSNTIIQRALMGNVMFLLKPLNIFIQYFVDHFGDEKTRREKIESRYPVSLDFGFIYPTVLLCFPMTLSYSVISPLILFIGAFYYITTYLVFKNECLYAVGNNFEAGGIHWDLVCKYVIYSLIIFQSCSAAQIFVLGSKLGAFSIIPMIIITVYFKKGIETMFTKSCNYYPLNVQEEQYIDEFSAKVLQERTLLLEDWDETADDIDIDSVGLDSLGFCDVEEQGKKFPYRDPSLFSSFSRLFLPHNFIKTMCFIEKYDKNNIFKMRDETEESKGFFGWILSWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3K4</accession>
    <name>A0A4Q9M3K4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0023p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3K4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="491" mass="58096" checksum="D29D72E51FC4B443" modified="2019-07-31" version="1">MDTCTSNIVEEISTEDVDNAIKNDEIYLKSILEKIFRQFSSYFKKLIKVDGYLTAYEINLDCLFFNEMNYFLKFEVENIDLGFVTVQNNEKNIKEFDCTKIFENNYYNIIDLLNAVATWIISLKNYQMHILSLDFSTIPVFNSLFTLLESELDVKFDFKKTIEDILRGLNPLLRIILPEFEAIRDLLIQSPILTSNNTNIQLEILYLCILIQKIETEYKELLEYQRNIMYSFNFHENSHDNTFKRFKISLRIAFIRLINLGGVSDAQIQEYSVLLLLDSIIKLKRKGKLFFSSYDGLYSFVSCRIRFFLYDTVSNSEYNLYMNHLKNFLQKYLNTFEVDTSRLKKLENELFEGINSILTISNLKKKLNEVKKKLLVSIDCVLNHKLPSIKENDDLDNYHIIETIFKGKFPIIKSSRENGDFYLHIKKHGLFRMSPIFYQRFENEIIIILETYIYLLNSATGEKEIIAICKFLDYKFDILNELLKQGNFREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M496</accession>
    <name>A0A4Q9M496_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0019p0090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M496"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M496"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0090"/>
    <dbReference type="OrthoDB" id="2189586at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="327" mass="39009" checksum="B0ADABC9BC0CCE3F" modified="2019-07-31" version="1" fragment="single">VENILVAIKKETFSILSNLLLEFGNYKNKFMDKNGLKIVVQKSENIEFNLFFLLKNFLYESNWDTKTYFIKNTEPDFFTKYIGEPTEDIYKKIISCFKNEIEFDKYYIKYRKLEDPDMISQTNNYLNDDISYIEITGRSNSSRNNVFENLNTSKEKPLNFQQNIPIQLSVPAMEQLMNVLRNLLCGTKEELKYIFRRFNSLLNSIFCYFKKLTSRVNRSNFPIITQIIYIFVNLSANNLKYKKMMLHDEIIDGIIELTKFKNKKLELSILWLIINLSWKEEEGVKNRIKILKMKGLFNWLKFLEYNDPVFTDKVQTALENLSFYESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4F8</accession>
    <name>A0A4Q9M4F8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0263p0030</name>
        <name evidence="4" type="ORF">CWI38_0071p0050</name>
        <name evidence="3" type="ORF">CWI38_0343p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000263">
        <property type="protein sequence ID" value="TBU03629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000343">
        <property type="protein sequence ID" value="TBU13763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4F8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0263p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0343p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="121" mass="13977" checksum="76CF3C1E5BDA1B33" modified="2019-07-31" version="1">MIERDDKDNHLDSYLHKLLDSSGSSCEDKNEITVKTESPTIFGNEKRSKPTEPSKEEDSDDSSMYLYTVSLYSSAYNDFIDGKDEVLEEYRDEEFSESNESDDFITALKSFLKRESESEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5B8</accession>
    <name>A0A4Q9M5B8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0007p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5B8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020563836" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="13833" checksum="AD649B4BEF66304B" modified="2019-07-31" version="1">MFISIYIFAFLFILFQILNIKATSGNKTNSDLTENVSDKTNKTKDCIQNTEANKKLQDHVDTEKVKDTSKQVADKIGGKKDQAINKSKEITNNATKKTAKIAKGNTKKAIEKIETKLNDAKPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVJ6</accession>
    <name>A0A4V2JVJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit F of V-type proton ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0150p0010</name>
        <name evidence="6" type="ORF">CWI38_1760p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000150">
        <property type="protein sequence ID" value="TBU04332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001760">
        <property type="protein sequence ID" value="TBU10438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVJ6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0150p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1760p0020"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="97" mass="11016" checksum="465467FB9F54D629" modified="2019-07-31" version="1">MQRTLVGIISDEDTITGFLLTGLEFTKENPNFIAVCDKTTEEDLIKSFQNLVSRDDISIIFIGDFAYKKISKTIKEYKEMLPSIMEIPSKLGVNKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWE0</accession>
    <name>A0A4V2JWE0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2388p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002388">
        <property type="protein sequence ID" value="TBU07522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWE0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2388p0010"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU07522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="756" mass="85013" checksum="AE78302A3DFA0ED2" modified="2019-07-31" version="1" fragment="single">EKKKEEDWKEESIKEEENIEILEEKRNIKYCFLNPINKLSDYELEEQIKEVVRGKSIDKTYLEILSRGIGIHHNGMNKKYRELVEILFRTKHLNVVFSTDTLSLGINMPCRSVIFAGDSLYLDSLNYRQMAGRAGRRGFDTLGHVIFLGVSKRKIQNLMVSKVPDLKGSYSFINSSLLCFNKEYLISLFKYPLFDMVGVVGGDSNLLESGLESGLESGLESGLDKGKENGLGGKENGLGGKENGLGGKENGLENKNILDNTNNTIINNNNNMSVREVLIRRMYYNLLKYKFIEGKGLDNMINEVIKGVLDNTKDKGILEGDIDKGILEGVNNSTNKQQGVSNSTNKQQGVNISTNKQQGVNNSTDTTDKHPLSNTTDKHPLSNTTNKHPLNTTSNKHPLTNTSNKQHPLNNTTHNNIYLTSLSDLVISNISCDSSIFLIIYIINSNAFNPLIDLEPIPFISLLCNFIQVKPLPFKTSFTLPNLNNKIFKMCKNINKKYLKESRFLYSKEVLFLERHGSGCVGDSGGSDSDVGGSGSDSDVGGSSDSNISNTSNIGNTSSNTNTTYTTYTNNNYTNNYTNNYTNNYTNNYTNNYTTYTNNLNTNNNYSKTLSLKKYSSFFYVNYLESYKNSYILDFFLHGRINDLESVNCVKVKELFCSLNIFYNFLDSLLKVMEVYGVSESVRKRVYNVYVMFGNRVRSSVNDSTKGVNDKDNIIGCVNDSSKGVIYKDIIRVVLLTPSYIILIINTKNIIFSIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM1</accession>
    <name>A0A4V2JXM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0811p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000811">
        <property type="protein sequence ID" value="TBU12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0811p0010"/>
    <dbReference type="OrthoDB" id="2187767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="25781" checksum="6AFAFAF1DBE895F8" modified="2019-07-31" version="1" fragment="single">FFKEGVIIVKRYLECHGYLPLNLTDEMIELICLLFSNNCRNPNKIFMNFLKFEFKGFCCDLDNSTFKDIEEKQIEVIFNKDKAILIYPEEIIERLKFLNSLTLKNNIFGFNLSFEIFGDKILFPSLEDYDFVLSMLERSGFSKIGNKIGNQFMLKEPISTSIIFPTDFFHDLNNFGYFFYSPNYKILMVKSKNNFEVDLLCNLILARTSFQFIKFFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS7</accession>
    <name>A0A4V2JXS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0587p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000587">
        <property type="protein sequence ID" value="TBU12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0587p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="292" mass="35062" checksum="9398F07C5AA0297B" modified="2019-07-31" version="1">MDYSISSFASLFQENIFSGKIKIFEFLDLKYKLWEISCQIGCFIEFFDISIIFEELDLNEFKVKGTFFERNIRKIIINDSKINSSFLEDILDLYKLKRLKIFESEISLEKTMNINNNTIECFIYRAKCHESCRYFYELVNLMTNLKRINFLMDRRINLRWPDAVKINIRHFEFLDVFLYKEYIDISEMKLLSNFEPKELLHLSAKCETGSLKCLFSRNNFSQVKNLNLFRFVIGNEDVKVFKNNLNLENIKFIDINLRLISISDLFCNAKDYNIKYIYLSNILFPIRFGIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY19</accession>
    <name>A0A4V2JY19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0280p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000280">
        <property type="protein sequence ID" value="TBU17623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0280p0020"/>
    <dbReference type="OrthoDB" id="2195425at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13120" checksum="F5B64A0823F7A37B" modified="2019-07-31" version="1">MLYVGGLPKIVFKTQKSKTKIEFKCCMTKEFCVLLYSDNTCYVDNQMDKVCFVLPIHLPSFIHKYDKKMNLPDSINKFFVFKSKEDKEMFSKYCQDFNDLKIRKIGFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY28</accession>
    <name>A0A4V2JY28_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0274p0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000274">
        <property type="protein sequence ID" value="TBU17650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY28"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0274p0010"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046948">
        <property type="entry name" value="ATL20-22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279:SF9">
        <property type="entry name" value="OS01G0116300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="51701" checksum="674BA387BA216502" modified="2019-07-31" version="1">MTKKLSQYQPTNKKIKTNTIQPTDILTPLQNTNYNENEIAKYLQENNRENSNKNRENSNNNSSKNRNGICMSSKNSNKNRENINGICMSSKNISVCKDICKDRNRNSKDKDSKYSNKDNNTTDTNNTTDNTTINTTDITTNQQYIANQSTITSNTTDIYDTRTINLNIINALIYNNHGNKDLDNTNNNIYLSNTDNTNIFNIHSVNNNDLRITRIKFKQDILNIDMDRDRDVVNVQDVGGEDIQDIILMCVRRHTQRRVEGAGGTQRDIQRLIDVIRQLTCNIRELRYFDVNPIIFKYGGYVKRLSDEELYLRMWGVFKVFERYKMSEYEIERLRVVMYRDIDILGDVFESSLSESSDVREKYDKEEGRYHNREENYKILKNVKKSYKNIQRLCDICMSEYKESDKCIILRCNHYFHYKCLKHWLLINSTCPYCRKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF9</accession>
    <name>A0A4V2JYF9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CWI38_0004p0020</name>
        <name evidence="20" type="ORF">CWI38_0006p0110</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0110"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="19">
        <location>
            <begin position="270"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="508"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU20973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="608" mass="70485" checksum="E537BAD9FF147430" modified="2019-07-31" version="1">MRILLTSDNHLGFKENDPIRGEDSFISFEEVLLIGKNKNVDLIIQGGDIFHENKPSRSTLNKTIELIKKHCFGDKTIRISSIQPLNFYDPNINISIPIICIHGNHDDPVRMLSPIDLLHTAGLVNYVGKTENLDLIEIKPVLIENDGIKVAIYSLGYIRDNRLYRAFLQNKISYIVPENKEDYVNILVVHQNRIPHSDKENLPIDFIDPMFDIVMYGHEHESIIFKSEKNGFYVIQTGSTVRTSLCEGESGNKFVYILDIFNNSSLDERIKIESINLKSVRPFFMDFIKVFDSSNVEKILINKVESMIEMALNNCNTEESLEMEILRQNSKNMRHFENLNLPLLRLRIELINGEPINKIKFGMLFEKRVANCNEIIHFVRKTKKVDIEIQNVETKLQITDIFKEILKSIELKAIPEIILVEALKRFVDKDDKEVFEELVKTVLENVVKKVESTEESLVEEIQTYVLQSKNEKALEFAKEISGKEENIFIENQNFLTKKNFKKLSSVNSKSNFNKNESNSSENENISKRFEKPENKKTQRKNKKTKFSENTNEDPIKPVFKTTLLTAKELFQKQNTPEDSPDSNREDIDLEIEDSISDDLDKYTFTNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUF9</accession>
    <name>A0A4Q9KUF9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_2168p0010</name>
        <name evidence="4" type="ORF">CWI38_2009p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002168">
        <property type="protein sequence ID" value="TBT97609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002009">
        <property type="protein sequence ID" value="TBU10116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUF9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KUF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2168p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2009p0010"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="73"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT97609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15809" checksum="149A709B021E4C75" modified="2019-07-31" version="1">MERYRNIFQLYAKQPEETVESALLGSLLRQSGHAVTESLVSSLINYHNKEYMNFEEFYELTQRAKQNEITHNDMLESFRAFDTEKTGFINVCQLKSILCEGSERLSEEEIEELLQILNPDSDGRINYECLVNKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KX74</accession>
    <name>A0A4Q9KX74_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1408p0010</name>
        <name evidence="13" type="ORF">CWI38_0201p0050</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001408">
        <property type="protein sequence ID" value="TBT99255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KX74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KX74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1408p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0050"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT99255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="196" mass="22759" checksum="E7CAC592EFBFB48C" modified="2019-07-31" version="1">MDIKKFEKYLRKLPTEEKILNNEKRVSVLKGQDIFLHLKKQDIQDNEIQSIMDYLISQNTLVRVVLSGQQNCMLQLSKTFKKTDFYIWVTESTSSTNLIISLALIFLSLALVMYQVWPSKLRRCTVYVAYPLMAFVVFLIVLGILRLIIFSITFFTNSPGIWLFPNLFADVGFVDSFIPVWSYHGVDTKPKKNSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L874</accession>
    <name>A0A4Q9L874_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0233p0010</name>
        <name evidence="3" type="ORF">CWI38_0014p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000233">
        <property type="protein sequence ID" value="TBU03784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L874"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0233p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="270" mass="31261" checksum="3327ABD14A4E57B8" modified="2019-07-31" version="1">MRFLVIYFGIFLCSDRFYNILRKSRDEILAGSVDNRELKVIDCLPLEFMPIVTSSPIFTHKISDDTTSERKIGQNNNPEISQVSQFENIERKRCRSPVKDDFVSKRRKTYLDSTHLNRSSISVPPDIDISSIVAVQLKTDKEEALSIQNNENEIDLVNYDTSELYNKKNLNAKTSNKKSRRTSLNRQMGSSNIVSTMNSLCDPEENHDTKEDKQKAKRDRPFSSLKRNTSYCNSTKLTREPQSLRRKSENFASFLEKFNPISRNKKKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L912</accession>
    <name>A0A4Q9L912_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0168p0040</name>
        <name evidence="5" type="ORF">CWI38_0382p0040</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000168">
        <property type="protein sequence ID" value="TBU04217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L912"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L912"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0168p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0040"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="134" mass="15919" checksum="7364A587FF755BCE" modified="2019-07-31" version="1">MPKIPINPPEGFTAIEDMLNKLDYKMKEAINLPIQKKYSHNFHQIFRLNHQRSRYIYNCYYKDKSISKELYLYLLDNLYADRYLISYWKKQGYENLCCVLCIDNSCICRVPLHKIPHTELVECDSCGCRGCSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LB86</accession>
    <name>A0A4Q9LB86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0064p0030</name>
        <name evidence="2" type="ORF">CWI38_0434p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000064">
        <property type="protein sequence ID" value="TBU04984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000434">
        <property type="protein sequence ID" value="TBU13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LB86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0064p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0434p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="79" mass="9042" checksum="DCF67C10AC77AB4B" modified="2019-07-31" version="1">MNVEAYIQSIVLKETSKQFPLTDEEDLRINPPLKQLKTKNITPLISEEGITLEEPTINKNEESDLEEETTVVKEVEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBF7</accession>
    <name>A0A4Q9LBF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Forkhead domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0043p0040</name>
        <name evidence="10" type="ORF">CWI38_0050p0060</name>
        <name evidence="9" type="ORF">CWI38_0893p0010</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000043">
        <property type="protein sequence ID" value="TBU05159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000893">
        <property type="protein sequence ID" value="TBU12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBF7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0043p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0893p0010"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU05159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="238" mass="27603" checksum="54B5AEFDA394D829" modified="2019-07-31" version="1">MFENKHSTEEDSNISEIHTDIDRCNTGPIFLNKLHSDTDIYTPRVRYGKSSDTKKPGFSYSELIVQAISSSEEGKLTLKDIYAWISTRFPFYTREKAGWQNSIRHNLSLNKIFYKIPKSPHSKGKGSFWSINTDFLKPSEHKIRRYTSRAPRCRNTTFIKTHFSDIENKNSLVEILDNNRTFLHPICITEPKISDKPITTVFTGDLNQLSDSLDTTNETNLYSIHENTSTNHIFKFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG70</accession>
    <name>A0A4Q9LG70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2457p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002457">
        <property type="protein sequence ID" value="TBU07079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2457p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020717156" evidence="2">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="479" mass="57482" checksum="160B536FBBAF189D" modified="2019-07-31" version="1">MQIFYKSLIWNIFFVFCKGSNDMKISHGDIKDNTIDKMDEKGIDKETYKMNDKGDIKDILNEISLFSNELVEKMKNESIFDDRPVCLHLKFDVDSVDHINSLMKETFQTNFSNSKTYVLVICVEKYFDNDEYFFKFIGDLLRKCDKKIRKREERYEMNNINVKDSNSFGRCFRRTKEDEKEFKMTRGTATDVDEPARCNKRTKDSAKEYDEMSRKPSSDSDDTMIFTKKYKNSKYFLYKFKKISTLTTLHNIIDKIKYESKKEFDRTITIAFNNRLSTYEGIMILNSLRNNPDRNINELILLIKKEFYNPENLIEFKQQRHLLSTNTISMFMYITHEPEIETYKNGDMSKSVLSLSKFNLSDNNYEENVGERVFDFPFPIFNNQKFANQIIKINNFYILPEVMFKYSIRKKFNISKPTITIFELKFSFSIFSDIKHFKKYTFHFIYNSKENIINMWCIKKKQKYILKVYFHKKYVVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGA1</accession>
    <name>A0A4Q9LGA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2451p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002451">
        <property type="protein sequence ID" value="TBU07118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2451p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7206" checksum="AC9A35CAB6FF0031" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPEYIECENDNVLKCLVETSGSHNENLSLSTIPTLRKQKVSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIM0</accession>
    <name>A0A4Q9LIM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2344p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002344">
        <property type="protein sequence ID" value="TBU07837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2344p0010"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="30681" checksum="D4261B4B32772038" modified="2019-07-31" version="1" fragment="single">MKGQIGIYNKNKNLIYFSSNKNSNTSIVFISGMYGGLFEPVYTKEIYKMCRKKQINFFQPRLSSFPNFGLFTLENDALEVLESLKYNQSENIILIGHSTGCQVIMYLIENYGEDFKERVKYCILHGPISDRNYEEHVNRDLPKIIKEVTNKSESEVFVYENTMYKKERFLDLYRIGGKDDFFSYDLENTFFENLNKIEFKILFIISGNDKFTKESNLNKLKLIKGGEVKIIKEADHFLKQKKYIKKFLNIITKKISRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMA8</accession>
    <name>A0A4Q9LMA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2143p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002143">
        <property type="protein sequence ID" value="TBU09503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMA8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2143p0010"/>
    <dbReference type="OrthoDB" id="10692967at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22124" checksum="0DA68F72F245814D" modified="2019-07-31" version="1" fragment="single">EQQGVNITTNTYHPLDISQDEQHPLDISSNIYHPLNTNTTQHPFNNNNTIYHPLNNNYNLHDDVKRTFLLLDSICEGEVLFRDKLSLRVIGVLFNHTEILEVREMVCRRVSRVLRRYVKCVVNQSMSYKVRDMCVRVLECMESVKDKSVIECVKKEVLDCLVGMEWRVVDCVRRVLSIMFSDIMFSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMM4</accession>
    <name>A0A4Q9LMM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2175p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002175">
        <property type="protein sequence ID" value="TBU09186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2175p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6287" checksum="65AEA029E4A0201F" modified="2019-07-31" version="1" fragment="single">ILPLILDGITTAKEPTTNINEELELEEEKKWLKLWKELFRKEKNLFTQNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP53</accession>
    <name>A0A4Q9LP53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1947p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001947">
        <property type="protein sequence ID" value="TBU10198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1947p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="20326" checksum="76B96D417218675A" modified="2019-07-31" version="1">MLLQLLAFWKKDKNTNKMHFSPIKNLLKAKYRLKEELLSVCDSSRWLKKEKIWPSLSTDGIYQHYNKSVPKNSVEAISFDRLRRLDSRRNVEEREKHVEPTPFTTANYQARWLEPKISINEEFMIEENIEKCENCSEFITNIDHMEEIKVGPCEEELGRISKRLIKKMCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP58</accession>
    <name>A0A4Q9LP58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2004p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002004">
        <property type="protein sequence ID" value="TBU10124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2004p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14262" checksum="48531789F55563FE" modified="2019-07-31" version="1" fragment="single">MNTTKINIMKRRVDILIFIYFYLNSTILMEIVRVVDPETGNILSAETLNMENGPFTRQVVSMATGSPPMNRLLTSGQVVHPSSDNSGLAKIDSEKETDPEDLWSFIPIRGNKVLFVGKENMCLKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPB6</accession>
    <name>A0A4Q9LPB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1958p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001958">
        <property type="protein sequence ID" value="TBU10184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPB6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1958p0010"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="28364" checksum="365D12B41E3B7E63" modified="2019-07-31" version="1">MTVTAIRNVLVGDEVKEEGIKSIEIINGSVTTMGTLFLYEKPNETNSSISNNKGTNTPLHTSNTTNINTHLYPSTLSTTNTPLSDRRWFVYSMTERVVISVGDLVIGSVIYVCSEYYKIELGNGCIGILPLLNFINANKRNKPDLKKGDVIYSRVIKGGVEVLLSCKEEGLGVVGCYFYVGRKKCVRLLFDKHYFKECLGNIGRGYKYRIGIGVNGRIWVESDSVKDIRDILYIERIKGVKDIRDIVLMIKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPC0</accession>
    <name>A0A4Q9LPC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1890p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001890">
        <property type="protein sequence ID" value="TBU10268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1890p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="291" mass="35396" checksum="9AF435970D9F4CDA" modified="2019-07-31" version="1">MFIRNEDKQYDTCIIRSIEKIGLKFEIFENFYAVNSNIEIFFCHHIKKSEVLLFYEFLISYYFPHYKMTIDMLYTILWFLEYFRAKEIHIMVINKVSFHFSKQDYFSHVLYKKISQEYCKIIKFDMNSVISYSTNENLSYFFIYCKGLYANDKKHILIINDKLNLFLERYKIFTYTESKEKEFDDFDDILFYMGSIYDETIRSINNNINFVDLKNIILIKSQIKTSLSFHHNLSKINGFIFYENTFSDKGYEVFRIKDLKNIDIGENIIQNIKHPFQKFVTQNQLFIMSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPC6</accession>
    <name>A0A4Q9LPC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1889p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001889">
        <property type="protein sequence ID" value="TBU10269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1889p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1134" mass="134841" checksum="737C112D010436B8" modified="2019-07-31" version="1">MVEDEIEINLFHIIKTNSNVDIQIYKAIEFVKLFQTTFPSKIAPYFLKHSFNYLSLHKKMLNYLNLETKTRFLPGMFSFYFKILKNIKKEKEHFIIYDCMSIYLKNVLNEKISEESKKRIFEFFYFNKIKNYKNKTELLKLVFEKISEKDKLKFMCINVLNDIEMNEENYLSLNLFIKNEIFDIYNEFIFKIKSKSNLKSEAESNFKHLTLKTLKVNSLFTDSIKKNNIKDTLDDFAVENQKENNEISFQIKNIAFQLEIPLKTIDSLLKIQKFEYDDRIYDIINEIYSKNYYKRKIIESILKNMHLYFYRNIKNPFIQFLPVNEFTIQKLTSNYSLENIEKYLEKCNKTNMDYHMDSYNLLLKYLNDTTDLNYIFNSNFNKIFSVKKLIEKNYEKILNEIFLSLSSQSEKNRNFNRNELQFMVIFRNLIEIRPSNRINEIIKKFIPEFHKNINSEVCLFQFGLLKVVLRKRILNRKTLKFIFKEFIFCESNEVDINSDLFDIYGLILDDYYLMDFYLEEQRCKNCSGVECNNKGCKPEKILEKILLEPDSLPKKKTQENVNIIEMHQTEIYNEFKMKLIKFEHNKSKNSNEIAVNKYCIFGFDKKNVSNLLSFLSPRIEIQQINDLDKDNVYVLISKIWDILILKSIKESDTSILLLFIKMIKYSKDFLGKRMQTSKILKNIIDDHKNFNLLEKSRFKIFLFFLLEIIRNISLYREYFFYIFNILLDLFDYFPNMKKKIDSDNIKNEEIKARCSDYIRALPPKPTIYNKTHSPSSTTLYVTPVSLIDSAPPSSCLDSSACIPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWLDLLLQQMPRNGWSAILRYYNRKFGRTVDIDAEGEISLEKKRERCRIKEIGDVAIRTRKLPSEFVESKVLELKNRITGKYAEFSVHKNVCDAARIIQAAHNEALNVYEKKITMHESRRKFRKENRMFEIFRVRFYLGLTERVESEHVVYRDEISEFWSTMWNKNDKVVTYDEYLIPFVSDTHQTTFPLLEEFIDIINWLPNWKAAGIDKLTSFHKYLYDIVKVICLEGTAQADCQTCVTKVVQIEVKTSILSDNSLGAVRGYGNNLKETWIYVEKTYDPTDPAYFTQCIENLYLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPH8</accession>
    <name>A0A4Q9LPH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1812p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001812">
        <property type="protein sequence ID" value="TBU10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1812p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="36624" checksum="FC86FF11BFA0E632" modified="2019-07-31" version="1">MVNKLSETEITGNQEILTMNFDEISKLYTFTEIESFFYDWVKNSKRKTEFIKECISFLEKKIQFEKLYETTVEKYPKLYFDYIEKLEKENKTAILEFVLHKAIKKTNNISLKFKLVNILLKNQEYKESLDIFYDIIDNNKFVDFFDTELSKEFENKDNQEVSTDTLIKNKKANDKVNFENNLSKTNLNIFYKIFLTLIENLNDIQLRRIIFESTLNYFISSVEFFNEFENIFLDLLIRFFMFEVENKEIKRCISLLQLLSDVFTNIKDLLNNLREYNMNNINEFSLEDFLFVQDILKALLTNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN1</accession>
    <name>A0A4Q9LPN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0157p0030</name>
        <name evidence="1" type="ORF">CWI37_0670p0010</name>
        <name evidence="3" type="ORF">CWI38_1798p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000670">
        <property type="protein sequence ID" value="TBU01601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000157">
        <property type="protein sequence ID" value="TBU04293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001798">
        <property type="protein sequence ID" value="TBU10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0157p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0670p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1798p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="285" mass="34922" checksum="E49D8CCD51875839" modified="2019-07-31" version="1">MKIAFYGEIIYNEIPKDCNYIEIISNEETVYYKANIPYYIKPLDYISHLNGNICRYEWYESIKIIFNFVFVENFLVKKGLLNFREFENEEVLNNKITIKGNNIYQIYNPIRKLYEYFDGKYIYLECEFERQFIPKYSNLNLIIENTEFDILKKVVEKNKIYYKIRISLNESHLIYLFSENNFLFRIESKLNLKYNFIFHFYTKKNKMLNIFVGKICEKWNDKTLIIKLNKNDDAFEEDILEVKKKFSEYTLPFKEIHKNQIIIEIENNEFHLTEELIRLQFFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN3</accession>
    <name>A0A4Q9LPN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1791p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001791">
        <property type="protein sequence ID" value="TBU10398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1791p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="921" mass="104850" checksum="72B6EBEBA7ECC4FA" modified="2019-07-31" version="1">MESEKAIELFHKEFEIAIKEKKNFEIKIEIENFEIFMISKSIDNTDLKSEFLIPFTESETSAKIEKTFNNKKLSCLIFSDFDSKKDIFKSAKVDFNNLKAQMDKLSKIISLGLILRGKSPFKFFIMLSQVILHIFDRKIEQKNICILKMIEVFKSKILQIKFKKDHKFDFINDKKFDFEKPDDPNKENIQIPLYHNIIKSLVNFYNFFIPIRNLPSNRTDVTSRISDTIRDYRVEEIDLNPLGLHSNPLANSTPLNEHRSREILTDTVLASESHILNNNIYSPEYFNSTDLNITARDIPGTANAFIAHLDFISNINNSENQNSSSSINSANYGDISEAVCLQMNENLSQTILAESCLGLQPEQETEEEFLNNSKPMNSNNESKIPDLEDSEGFIQQNLESNSPRIMTSQENIVPLSFSSNKALNELIKCESKYSLPHLEDSDTTPQNNLQTAIIQTQETDNLNQTLQITNSDENVSCISNILSESSFQLSINNSNSSNIIYPSGSNNEDLETSISTSRHNISPNNQTNTMHSPTIFRPQIEPVRSHSQQNLYESDTLLQPKTPETSDISHTNTCFANTTGILGDNSFEYLDESDSACVIQENASLTVQNITNALICDQPIIYTAEKQQEKYMHQNRYTSSNHKCMNFNCIETKKNIPRNAELILDESTSIIYAEINPIETCLFKPDINPPKLFQAKETLSTHSFTNASETSIETIETAEQQENTLFKQEIVSKYFYLFNVHSERIKSDSDNNLYEIVSLSPPDQSYTELTNQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQETSVPSLDDHDAFIKWIEEYNFNKSPDPSKITEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPQ4</accession>
    <name>A0A4Q9LPQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1743p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001743">
        <property type="protein sequence ID" value="TBU10463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1743p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17656" checksum="E9038BC1EC6B64DD" modified="2019-07-31" version="1" fragment="single">MVSNKILEKKLYVLLLCIRFILYISSSKVVFFVLNDENCITDLCHSEINLEMIFAENKSVECINEEEKITIFKNNILRYEAPSKQPKYYNPNIHTLHHRNNMLFNSKLIKKYLDSKSTNIKIFLKDISYPALLLFLKLIDNSDSFISQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ77</accession>
    <name>A0A4Q9LQ77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DSHCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1943p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001943">
        <property type="protein sequence ID" value="TBU10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ77"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1943p0020"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase Ski2/MTR4 C-terminal" evidence="2">
        <location>
            <begin position="312"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="615" mass="70072" checksum="4D80B9F086846872" modified="2019-07-31" version="1">MGVVIKNGNLYGIIKDIKGDNIVISNKDIYTDIGGVSYNEEGVSDSIDKQQGVNNKSSKEEGVNKTYKQQGVNNNSSKEEGVNKTYKQHPFNNSIDEQHPVNTNAYKQHPINNTKNITQHPLNNSTDNNTYSFTLPSYPHMYIFPVKEDLIITIKDIFYITNTCSNKDNNYGLSNCYIDFTINSIEGVIVKERLKKVLVRLTGVNNSSCSLKGCYDHIDSNKEITGVNNSSQCLKGCYDHIDSNKEITGVNNTPEYLKGCYNLLDHYKVLLQSFYSLKNIYFLFNKHSSKHLSLISEYYMRIRVLKYIKCINENNRVLLKGRVSIEIRSCYDLIGMCLIFNGVLSNISGEEIMSVISCIIEGVNNRIYEGSIMEGVISKDSGYKGVSNSTTRLEGVNTSSNTYHPLSDSTDKQHPFNNSTNTYHPFTDSTDKQHPFNNSTNTYHPFTTSTPYITYLYPFPKEKQNIFINIYNIVNNTYNYITNIMKSFNLQPMYTPCYYYILPIYDWCTGKDLLYINNTYNIQEGDIIKVVLRLIEVCKELKGVSVLIGDMVLYNKIEEIEKCINRGVISIPSIEEIEKCINRGVISIPSIEEIEKCINRGVISIPSIEEIEKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQF2</accession>
    <name>A0A4Q9LQF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1667p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001667">
        <property type="protein sequence ID" value="TBU10584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1667p0020"/>
    <dbReference type="OrthoDB" id="2186471at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="Zn_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon 15" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="19241" checksum="C8274575386462AC" modified="2019-07-31" version="1">MDSAPENYPQVPGQILCMYCGCRGNAVYRRDDFYFTFFFIPLCRLKKGNPYLSCDVCRSRFSNFGTNVCKKCRTAVPGTFHYCPHCGAKEEMDIQPTNSDSILMECRIWGMGYKIWYMKYEVWNMGYKIWYMEIWGMEYKIWYMEYEVWGMGIQDIRYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQF5</accession>
    <name>A0A4Q9LQF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1563p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001563">
        <property type="protein sequence ID" value="TBU10763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1563p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21059" checksum="93BC4E4D020BC58C" modified="2019-07-31" version="1">MNLSPMIRIVNSFSFKFSWTFFLKEYVKKDIVMISKRICDPQILDNAYAKIRGNIGIKTDTRYRYILDKNKRKITPIKVGITSQDSLQIVETEKPRNYDLVSNELGLLRCSVEIIPYVLTWDGIVIKYILNAESYIQSIVLKRSSKKSPLIGEKDLNAPGTKSPVKQPKEPTININEESDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL8</accession>
    <name>A0A4Q9LQL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-mRNA-processing-splicing factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2096p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002096">
        <property type="protein sequence ID" value="TBU09891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2096p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRO8NT" evidence="1">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="21188" checksum="8F6807F07732CDE6" modified="2019-07-31" version="1" fragment="single">MPNKNHPLPPEHYRRLINLPLSSKHTLPSLKYLPHSLLYLFKSIPFPWENIKYVKVRYHHKNILTFVQDKTRVTDYQNKWKFIFNEISTKQTHILSFPIYDDNHPLINYEDIVNYPLPTPFNISTNTDSNYKGVNERDIKKGVNKYSSLESVNKYTNYKGVNERDIEKGVNKYSSLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR44</accession>
    <name>A0A4Q9LR44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1417p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001417">
        <property type="protein sequence ID" value="TBU11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1417p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="16944" checksum="9BB3F4FE4C61C2EC" modified="2019-07-31" version="1" fragment="single">NVYAFSDILSIYYYVYRISRTEYLFLNKMAKIELLSIRINHKSDFIDFKMLFTDCNFFNTINFFSFHCKAIRKEDINILKKIKILKCLSLSCETIDYEIISCFKRKDFKTTKFEIYKPIRSERSAEINEYLDTEFKSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR47</accession>
    <name>A0A4Q9LR47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1507p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001507">
        <property type="protein sequence ID" value="TBU10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR47"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1507p0020"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28087" checksum="30BDE380FD059EBF" modified="2019-07-31" version="1">MSSFTLTITHTIPNPLLSRQLIKVKLAHPNSSTPKKDEITKKLAYLFQTDPSLVIVRNCRTAFGLHETTAEAKIYEEISTLNSTEHSYVIARKTGVVADKIQEKRNIKCLDLYEEICELLLRKKKEINKLISLEKRQSIYHLLLFLPMEEIMDKLKEIEGLIDSSKKLPQGIIESLEYESKMLFTYLTLKIALGKLTNTLDIKDLERIKSLKNNFEIVKERKNEIFDEKVENDVLKCLYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR53</accession>
    <name>A0A4Q9LR53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2094p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002094">
        <property type="protein sequence ID" value="TBU09900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2094p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="580" mass="65899" checksum="4B1439982AB90683" modified="2019-07-31" version="1">MDFFNSTNEGENFVLSNSEIAAMLIVLSGASNETSNDILIPIFFRLIQNSDSQTRLEQHVPLNKSNPIDSKSSLDFDPFGSSISYSYEPEQTSVDIVCDKYDTGIIINSRSSSDPGLDSTSDYNTEEPFPNNSKDSFCQDYSNLTEERNFERLLTLSRSSNSMEFHSLNESNNESRCGGNDQVKTLSNFSRVDSTSDIREIDDVFIIQGNSKSFDSTNDNTIHMNNSTEMTDYNSLNNREEILVTPRSFNADQTISSEINNDAFYPRTSTPISTENNISLQKEFHSKRKNLPSIFENPNEFNFKTPLPYNYGFFKVKTSESKENPASTSLEPKQKISKRPKLKPKKKLHRNTTYTVFKKNDTPIHSPTPADSNITGNTQVKSNDSLPSTSTNNLSISILSADSLPLLNSKNKFLRKNTQKSNVSKNGSDIMPQKRQLLNKIRKEKQIKRMKVMKRMKIRNTVNKKLSTNKAVNPNTLLSSNSSTSRAATTSKKSKTSEKISDLKFYFDSKNIEKYKKIEKYKKNQHERNKLRAQKKAFKIYLIFIVSTLGTTLEEPTININEESDLEEEKMVVQEIEGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP6</accession>
    <name>A0A4Q9LRP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1477p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001477">
        <property type="protein sequence ID" value="TBU10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1477p0020"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="37459" checksum="AB512B25B5F3285A" modified="2019-07-31" version="1">MYDLCKKYVIRKEIRDMTEKEWMKYKDALLKVYKEGLIEEITKIHVFVDDYAHNNDRFLPWHRMFLLYFESILQFISNDDSLCVPYWDWTLDAENPSDSIIFSEKYLGFNECLKLYFPSEHCLKRKEGIINPFYNKSKINKLLKIKKDYKEFREALEIVPHALVHAFVGGDDGDMSMMYSTNDPIFWHHHSFIDYIWHKKQKNDKNYNYNGKDNKGNKVSKEDILFPFNKRVKDILKLEDCCVKYKEYNHVKIQTYDDLNIYRLPESYIKRHKYSLNKVRKIENSLQEIKRQSRLKKIFIFLKKLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR3</accession>
    <name>A0A4Q9LRR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1561p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001561">
        <property type="protein sequence ID" value="TBU10766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1561p0010"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6535" checksum="C5DDC2434E9DB452" modified="2019-07-31" version="1" fragment="single">MSIFLGLLCFVFSNEVFRLMELLSFFAPGVDENGKSHRYAFYDDHIIVTYSSDKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX8</accession>
    <name>A0A4Q9LRX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative POP1-like ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1276p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001276">
        <property type="protein sequence ID" value="TBU11303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1276p0030"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="533" mass="64139" checksum="D290D2B07BBA2915" modified="2019-07-31" version="1">MSEQEKEIDALKFMTAREFEIKEMEDSLSKSTKKSQLFQRLPFYKRRRTRNYDTRNTPKIHKKYLKKLYLNRFRNRKLKFNYLPTHIWYAKRFKMIDLFNSKLPYKRNIKSDKFIYKSLERGFIFDESFKRIAVFRRNEIGNREDENINTIKSMQMKMEKKTVNEEELNEKLHSNIQMKIEIEKETVNEESKNGILKSNENKLESARKNINIKEEFVIKKYEFDFEGKNFIFESFFTKKYFIIIYVDCLEFKEFLKVFSKPFIFIWEGIISVIKNTTFFSQSGIYQKEKFINFEIDEYLENYIFPSRENEDCSLNETEDTNDGLNLQNETKTLQINKFETSEFIFIKSNDLLENGKIILRRKYLSNIFHFLINKGIIPISILELFRLGIECKKIIHIFDNLKNSLSLDFHSKVAIDIKNKDIKRPISKRINQYEYDFTNTEYFKNNFNSIKILYFEALQGCIERNGIIFQNTHQIGLVIRGSFCFTSGKSRGLCFVTEDVNTKEEYFARNFNSTKMCKIIFLLETLQTDYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS26</accession>
    <name>A0A4Q9LS26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1835p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001835">
        <property type="protein sequence ID" value="TBU10345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1835p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8474" checksum="F40E576354CDFC60" modified="2019-07-31" version="1">MCVNIRVLVIEDCKYKGVSIRIVIKGVINMCVNKRVLFIWYLDKRVLLKKDIYKGVNMDITIEIKGLSNTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA8</accession>
    <name>A0A4Q9LSA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1662p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001662">
        <property type="protein sequence ID" value="TBU10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1662p0010"/>
    <dbReference type="OrthoDB" id="2211145at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="327"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="483" mass="55922" checksum="F6B95F3C74F3347C" modified="2019-07-31" version="1" fragment="single">TNKGLDSHDINKGFINKELTSKSNKDTNKDTNKDNKGLINKELTSNYNKDINGFINKELTSNDINNQSCKLSPFSIKVRFYKAIVVEEGVNYSNIDNVCYLLIKEVNSSNKKEWVWVVNKGVIDKVYVSSIKGCYYSVVEGVIVFRSSSDKRVGCYSSSRDKRFLVETSGSHDKNLPLSTIPTLRKQMVSINDRECIIEKTLEGYSMSAISSNYRINYQTAKSIVRRYLKTGLEFVEKRGGDRRSKLTLEIKESLQTYGNFEQWVKCTFYVDVSTSTIDRALREFHYTLKRVTLVPERRNTLSTIELRTNYATSFRELEVDNDDKNFVFLDEVGFAVIIRPIRGRNIRSESAYLSVTAARSRNISEVSAMNKYGMIYHKIHERVINDEDFKLFFKDIHLSLMDNARIHHYQGLNDDEEIASYRIKYLPLYSPFLNPIENIFSSQLRILIYEKFNEITGEHCSSFYHKMLGYLQMAEVGQVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD1</accession>
    <name>A0A4Q9LSD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1205p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001205">
        <property type="protein sequence ID" value="TBU11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1205p0010"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="258" mass="29358" checksum="493326997CCB0A13" modified="2019-07-31" version="1" fragment="single">YKGVIYSIVLIISYKGVIYSIVLIISYKGVIYSIVLIISYKGVIYSIVAIISYKGVIYSIVLIISYKGVIYSIVLIISYKGVIYSIVAIISYKGVIYSICENDDGLEFSNDDLRAHNCKDISSIVPRYFKTGLVFVEKRGGDRCSKLTLEIKESLQTYVDLKVQSTFNIDVSTSTIDRVLREFHYTLKRVTLLRTNYETSSPKFEVDNDDKNFVFLDIVGLLTDVSLCFIFVIDNARIHNYRGLDDDEKINIFLGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM6</accession>
    <name>A0A4Q9LSM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1684p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001684">
        <property type="protein sequence ID" value="TBU10555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1684p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17647" checksum="4AA5AE7C001FC739" modified="2019-07-31" version="1" fragment="single">EGLYTNDKTHFLIINDNFNVFFCEKVAVNSKSLNLFALLLNTLDIKYLHIPNPNEKNTNAFCFVLENLKKKIDEIIFYLGSIYDKTVETINRNLNFVDLKKIVFIKSKIITNSIFQDHLSKIAEIIFYENKVSRKEYEIIKIMDMNNINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN4</accession>
    <name>A0A4Q9LSN4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1125p0040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001125">
        <property type="protein sequence ID" value="TBU11593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1125p0040"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="27476" checksum="40D91E6E34EA2ED4" modified="2019-07-31" version="1">MSFLKNLAMLFRLVGDICHVYSMIILAQKIKKTRSCSGLSYKTQYLFGIVFYARYIDLFKNIFYFDSFLRVYNNIMKILYLSFQSVIIYLIRFKYFYSIDKSLDNVDIRILLIPSAILAFPFKPKTFSFLGFFVEYFWTFSVFLESVAILPQLIQLQESGESETLTSKYIFFLGVYRIFYLIGWIFKFFGKVPVNHLLVASAILQGMLYTNFFVLYYKHIFSKKGKDFKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW9</accession>
    <name>A0A4Q9LSW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1638p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001638">
        <property type="protein sequence ID" value="TBU10630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1638p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="16355" checksum="B9EE29DC0790C6CC" modified="2019-07-31" version="1" fragment="single">MLSQLLDCLEKHKDTSTRRAAILKVENIYKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQLAKLYNEIEKRKLHSKLYNARKNELNIRPRNEAVFCYIQDRIVFWQNGMCQNSNQSKKTKMLVHDFYRRHNEVVRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX0</accession>
    <name>A0A4Q9LSX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1226p0020</name>
        <name evidence="3" type="ORF">CWI38_1096p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001226">
        <property type="protein sequence ID" value="TBT99759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001096">
        <property type="protein sequence ID" value="TBU11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1226p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1096p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="257" mass="28751" checksum="294B619B85764A6E" modified="2019-07-31" version="1">MKELETILILFMLNSGMINASDSDLRSQIGLPLPLFVERYPTIFDINCIMFVLFNILFFVVALLPQDKLEKFQKSLVAGIGAFYTVYHLSGFLPLIKIFSRLGSLAAAVVVAVSSYMNKDLCNLGLSIPSGYIAGYMTIAIIRSFGFFGFLFLFAIYTGIFFLLGKFREKEHYGACRGLILTYCFLVITSLLTPLSIFRSVHGLLWAGVFIIDIIGLLILISMPPAIFMYTVFKSKVLEVVLGKKDNKPQQKENSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ3</accession>
    <name>A0A4Q9LSZ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_1862p0020</name>
        <name evidence="12" type="ORF">CWI38_1068p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the AEBP2/jing C2H2-type zinc-finger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001862">
        <property type="protein sequence ID" value="TBT98186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001068">
        <property type="protein sequence ID" value="TBU11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1862p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1068p0010"/>
    <dbReference type="OrthoDB" id="2188412at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT98186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="161" mass="19168" checksum="F84C4EAAFB6BAD4A" modified="2019-07-31" version="1">MECNWLECNWLDCKYKAKDSNDLTLHVNTHIEKQSDTYMCLWLECQKYGEKQFSKYTVQAHVKRHTGDRPFKCNQCDKSYTRSDALNKHLKKHEIVTHNINMLVNKSFYLNLMLQSVDFKIRNEKIRNGKIKEAIGILRREICISYDSKSKNESNTKKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT18</accession>
    <name>A0A4Q9LT18_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleolar complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1115p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001115">
        <property type="protein sequence ID" value="TBU11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT18"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1115p0010"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="56711" checksum="00040BEA1D7F01CE" modified="2019-07-31" version="1">MSDDSNLTVLNNLSEDCKKIIHEPEKNILLVTHILNCSTEYLLPFKNDNDIKNIINLSLLKVFKHIIPLYKIRTSNEKVKLNKEQKNLMEYDKKLLNVYIFYLKSVFCKNTFESYKCACEILNELDHFNFLEKSVNKVLIGTISEHEEIKEMCLDSVKNKLEGNNEETIFVIINQMYNLKFSSSGFEFLLNIKYLEDKKISDLQLEENGKKDIKMEKKNKKMEFLQRKNEKKKTNEIFLKNLENNKNKMSICDKKREKSRRLNERIIDEVENSENIDSKRKTLKKIVDALLRLYFRVLYDKKTNFYLLTFDGLIKYKRFISQSFLEGLFLMLNNLEIQNNSKLEINKLLCIQSIFENRNYDFKKSVSIIYKILKPLEMDIDRNNLEKLKIIVINLFINMKQPINRVNAILHRLIQFCLIKRVDLFHDLIFILKNNYSVNFSDFDQINANNYSEEDIDLVSEKAFFEFHTFLKVANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT78</accession>
    <name>A0A4Q9LT78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1569p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001569">
        <property type="protein sequence ID" value="TBU10750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1569p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="43330" checksum="F475A36E2254B2B1" modified="2019-07-31" version="1">MRFSKKQKFFLLAGLGTAVFCGIPIVISIFIDRKMRNQLLKEFNDFKELPLTKILKNQLKDNNDIGFPNFKFNGPDVIGICYSFGEIKHFGFLNADINDKSIKLSLSGYSLKDEEKTNWIYTKEFFLFILHKANTFEKNNIYGSSHKRVLPDNGLREVIGNMLKNAIDSSEKLRDILPFLSNNIEELQQRLNQLLLRLETDKNLDWVQDEITKNIFWVFEMLVSTFIENKNTILEILNDTRAAKERKDEDLMDKNLTALRNFLVEFSNSYADKKFGASEESNLHESVKFLRNKILTELPRNKDISKIIGDCIQVFLDNFDDSEDAEGSGANVSFNDYGSLGISSNTDDSDEIVKKILYELVSEGILCITRFLMCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD4</accession>
    <name>A0A4Q9LTD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0998p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000998">
        <property type="protein sequence ID" value="TBU11878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0998p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26750" checksum="DF5BC28EA330E370" modified="2019-07-31" version="1">MIVKYFKKVGFSYVESIAEIAEQNETIKSFLGITLAIIGLTILIFNRYCSKILIYNHMSLIISALGWYFLTTTLNGNAAICFFVGSLCANITFIIRNRKSTDKNIYILIILWMIYFPFLDLAFDLHSVLFWSFAIVSLFMLLFISSYKFYLISNAFIGSVIFSVSVFFLFDYEKYHGLEFVRLETIYCIMLTMTITIFLHMNFSKPILNRVGESCDEIIESRVKHDEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE2</accession>
    <name>A0A4Q9LTE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0996p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000996">
        <property type="protein sequence ID" value="TBU11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0996p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15588" checksum="89649B11431D1493" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRELESGLNAEESWERASMGVIMKSEMHEEPIFPLKEAKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG6</accession>
    <name>A0A4Q9LTG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1418p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001418">
        <property type="protein sequence ID" value="TBU11041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1418p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="25953" checksum="A79770EA52ADBC65" modified="2019-07-31" version="1" fragment="single">MNDVINNVSEKILLPKTMSMKVLLLLLIVQNCVDIKLFYVDSRDDFDKGLENTIIINSLLSNTTIFVKDENKCYQMSEFISYIKAKHQFQAIHHFTVQYSSNSNFTVGLFERNREINTIFLGNFLEKQVNLFNLLLNDSNFFLYETLGGNTFLDFLRLSKIFGIQDDKKFETCLKELIQYYNRELKDEYFQNLMINFQTFQQEVDNWVILKSFNILGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ3</accession>
    <name>A0A4Q9LTZ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0512p0020</name>
        <name evidence="3" type="ORF">CWI38_0898p0050</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000898">
        <property type="protein sequence ID" value="TBU12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000512">
        <property type="protein sequence ID" value="TBU13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0512p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0898p0050"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="29181" checksum="071480C533040F09" modified="2019-07-31" version="1">MFINKTFEYFKLLNIPLKKTYYKECIADTIRKKLNEAKQSISDLQLMLERHCLPSFNMRKRKMSEINHKKAEINLLISKIESLFLVIEKQDLPESMRSSIKHHFATKLKRNLLFYRNIQQSFLKKISSLQTFEDLDSESVQGSVQEMVTIKKSSDSQNIKKTIFHLTTLLLEMKMIIQAQSYKIDRIDFLLNQTYVHIDKTNQELVEIPKYTSKLKNSIIYALSMFVFLLIILSILKAYKIRKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU19</accession>
    <name>A0A4Q9LU19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0932p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000932">
        <property type="protein sequence ID" value="TBU12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0932p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="424"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="714" mass="82217" checksum="5B16B66E7728A30F" modified="2019-07-31" version="1" fragment="single">MLYSIGFLNVGGLSVKKIEIINCVLLDNKLDILALAETWRDDIDNLNTNYRIVARLLSKKIKKRYSNSEGILILAKKSIYPQIIPSITDFGICIKSNDTLLIFIYKSPAVSAYKIINKIPSKYEGFDVLALGNYNLENSVAYEQIVLEQHAELGLYETKLAPFTYKHGSKTSTPDKCFSNFNVSPVVIEIEGMNHKLIKVQVGRVAAQLETNYNINLLKNADTLSEVRKSIETLTTKNEFFLNTLPIDEKLNLLHKILLKAARKLQIRKQVQRVSHNPILSHLKRLKRNKSANKDAQSVQLLRKEIRRLSRKLKRLGVEEGKVQHFNLQPSELHKLICASSTKRKISERQIRFAQLIFNEEELVLVSDTKKKIEKFYLNINKKKDTECDKLIGITIVELLDELKNLKLAFPMNFIGHLSVLFNQIIFEKKVPMAWKCHRIRLIRKEKKSYRLIALIEETRKLFEKCILRKLSFRLSTRQTGFRERHSPIDNALGVDHLLRKGAGELICVSLGIKSAFDTVYRWNLYKKLINYQGLSVNDTLLIAELIENNSYVLEHGNRKIDCFTASRGIPQVSVLSPNLYNVFIDDLLLYIPQNLRKNLFIYADDIFLFGATLKQIRKIIRCIQLHASDNKYELNQQKCFYNANKRCQIVVNGSPIEKQSPMHYLGLKAAIIMKNGLIKKVGIGNSGYYRLLLKGYVTFIRPHLDYTMFLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK7</accession>
    <name>A0A4Q9LUK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0931p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000931">
        <property type="protein sequence ID" value="TBU12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0931p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="519" mass="61521" checksum="8D75448B788497D7" modified="2019-07-31" version="1" fragment="single">MSSKNIFLSMINKRYFEKKMLYNIISIVYTLILLDFASLYNFSYRFTMNKESEILIFDEKQHNSVFFQDDEQELVFDILYSTESILYDEKLHVFTYSKGNIIEFEALNDLFGSDKNEILGRKIECNFNLRYFLKITKDVTAIPDKIDFEFVKGIIMVMKILKAVENKSWNLYFQALFFKTYRFYEKSSIGESEYKFHKHLNQNFWRQVGFDTKQNLTSALLNSLMVENILFDGNLILLESSQATYDKSLLDKHIPYKNLLLNNHKVLYTVENVLKDRTILSMFEVLFDEININSLILGNCHNFKILDDDFPFYVFAINSFKSITISNLEKCLSSLFLNKIKLVTEKNIEFLSLRNVLISKSDLSFICNTYILKGLVLNNVRTSEDFDFIEDYSDLNKTMEYINLKNVEIDYKWWNIYLETPIASKIILSLNTYFSQKNFIAKFKNINVLHCEEVLYLEIDFCYSEIFNHVCTKLFFFKSLQTLKLYGYKSNVNTESCLSEALKNMKALEFLYIKQYNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX9</accession>
    <name>A0A4Q9LUX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1133p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001133">
        <property type="protein sequence ID" value="TBU11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1133p0030"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="20723" checksum="B16743FA36D95724" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPVIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPIPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV37</accession>
    <name>A0A4Q9LV37_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1195p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001195">
        <property type="protein sequence ID" value="TBU11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1195p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="368" mass="42925" checksum="3A93FE95E8B249FC" modified="2019-07-31" version="1">MSNLQTFISQEKHLSLVWDVYQDVRKVTKSQIKEFELEEVKRKLIHYNTLRLPIWITSHFILGMAKILDKKGKYIFEDMMSIISIISKPRPKRSEHKNLRLAPFCRIQPVEPSEFAAEYENIEAADFLKDDFELEYDGPENYSHVEEAREASNMNLDSVIGEMSAMQSNSVHSNIIQNSFILHDSPNQSKESIAITDQKISKRRKIQFDRETQLDFDDLYFNQTNANNMILRKEKNLINDLFSKNISINSYLIDILKKKIEIESRQSVEVQRAETLLDTGFEPDFTTEYNYPSFAQDELDMSDENIYNDFFTIDSLPLEFTFQNIVEGLDNSKKALAFVALLELCNKNEIFATQDICTFNDILCCKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG6</accession>
    <name>A0A4Q9LVG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0667p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000667">
        <property type="protein sequence ID" value="TBU12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0667p0030"/>
    <dbReference type="OrthoDB" id="2194902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="37975" checksum="EEB706D4570B54BF" modified="2019-07-31" version="1">MFVLTNYNEKEPLEIKSKNPLILHKKVENITYQSTEVESKLNFYICDSKDTLENFIPVTLHRINIITDENFKKEDYISNCCNIDKNAKIKNEVPKNSYSKTVSVLNQPSKYIQPVLPPKNENFKFYDLENLFPKEIIQQFSNLNTHLSHLEPIYLQLYHKELIKIKNADKKNQECIEKIKKPKIEKFECIFTPETLKVHILILDCLHKLLTMEYHRKDLIIKNFPKKFNFFISYIQEFISNNRLIGLNKDKFCVIYYILFLKVNNFVSNLKEMPFYDNKEKKVIEMLRIIGCIVKNNEVKMCREPIYEVTRRDRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP4</accession>
    <name>A0A4Q9LVP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0633p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000633">
        <property type="protein sequence ID" value="TBU12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0633p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="52857" checksum="32A687ACEA2E5976" modified="2019-07-31" version="1" fragment="single">MSLPSTYKMKKFCRLKQKYVWLIFFYVLISLKNIRSYEYIYSYIKDMNSDILFFRENRTEVSFDQEIHNDCWLEIIHDCDIKHVNQENYLFRYTKENFLSFEELNNILFSNSTIKKGIIECSYELSHILKMTNDITFMPINMSSYQFKCILTTLKYLKAVENKNMVKLFQALIFYDFVYHLNNGSKSKPLFLYGAFQDDFFQNFEFVIMKNFLFAFLNIFMMNYSFENGNLILLDKCRVSQDISLLNKNIPYKNIVIANFKVVYIFENILRNCYILYSFQALLNFLDIKSLIVDNYINLEIYEQNYNFAIFSIKTFKSISISNFTNQSSLGFLDKLGSVIRNDLEFLCLMNLQISRNAISLFLNQKRLKGLVLRNLIQIEDIDFIQDYTDCSKKLEYIEFKNVILKDTWWNYFLQVANVRKIILYFCTLLQQKNFMKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR4</accession>
    <name>A0A4Q9LVR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0746p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000746">
        <property type="protein sequence ID" value="TBU12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0746p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19047" checksum="847FBBA1D6308911" modified="2019-07-31" version="1" fragment="single">MPLFKLRFAIPSNITIRIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW38</accession>
    <name>A0A4Q9LW38_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0992p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000992">
        <property type="protein sequence ID" value="TBU11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW38"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0992p0010"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="444"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="562" mass="64927" checksum="69F469C1E6B3069A" modified="2019-07-31" version="1">MDIDEIREKIVEKFTSSSLYTAEEISNCLEINRGPKGGDFYLQLARISKNVSRDYQELINFIIKNPSPLILSVSVLNNALAIKINKFSVLKQLCKNIFEKNDSFGKQDLGKNKKIIVEYSSPNIAKIFHAGHLRSTILGNFIKNIFKIFNYQVISINYLGDWGKQFGLIGVALDKYKNEEDLKKNPVRYLYDLYVRINKEAEDEPEIHEKAKQYFLELENGNEEKIKTWKELRELSIEKYKELYKILNIHFDVFEGESMFGEIGKEIIEKTDKLVCDVDGSKYFDLGVLGKYIVIKKDGSTLYSSRDIGAATSRLKKYDAEKIIYVVASQQDMHFKQLFKTMECLGYSTDNFLHINYGLVEGMSTRKGTVVFLEDIIDEAKAAMYEAMQRNQEKFLKIENPKFTTNTLAVSAIIIQDFSAKRVKNYKFDMTRNTTTEGETGPYLQYTHCRLVSIENKNKNLNFKDLTEIDFDLIKEESIAELVYNLSTYPYVLRESLEHFEPCKIVTYLMKISKMINTLFMTLKVYGQPENIAKARLSVFLISRIVLNSGMKVLGLIPLSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW65</accession>
    <name>A0A4Q9LW65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0569p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000569">
        <property type="protein sequence ID" value="TBU12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0569p0050"/>
    <dbReference type="OrthoDB" id="2195868at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031541">
        <property type="entry name" value="HTH_micro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17007">
        <property type="entry name" value="HTH_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="503" mass="59394" checksum="7362ADB4E7CA539B" modified="2019-07-31" version="1" fragment="single">MQDLKQKLFSFGIYGTKISELTQEEIILLLEKTWVEIVSHNEIKNLQASFTLVSLPNERLTAYNHYTKNGFDLFLLNFLKNKYIRMETVAWKDYLTNGAFNFVSKEYYLFINLLLSKNEFVHSSELKSALNLQPKKLFYLVKKLASLGLLEKKSYNNGYLVKLIRDENGCILTLKNNQPNINIQPSVRNQLNTDLNTHNLSKNELRFDIPLYEQIRRLVFQSAHGISSHDIFQKFGIKIKVGLKLLTKLSKINEGKIISRDEFDGKIKRTKFYFIEQLEKCKNKSEIFTSQEEPYSGNKMITVEDRIHAIECLIDQKGSFLLDRDNVDELKRILGVKYDLDRRTIINSAIKGGFNVCKSIIKDNNIRYVISDKNAKEDEQIFNKISQKESFEIKKLSKFQQNIYRYFVIYFKFLEKDNGFISDKNIRNKYFYLFLRNISTQKQQERFVFDHLIINEMPLYLILGLLSFKKPNFKNFIIEEIRKSLFNGNLNVKKLKTEIFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ1</accession>
    <name>A0A4Q9LWJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0647p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000647">
        <property type="protein sequence ID" value="TBU12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0647p0010"/>
    <dbReference type="OrthoDB" id="2187336at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="5">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13950" checksum="8BD1F2FB8DA65F6D" modified="2019-07-31" version="1">MLKSLNYIKSLFSFKRNTESKIKENLIKTVPLTLSIISPRSVFTNDFFKKEFFANFFKSLYIFAFKPFGINDIVKVHGYEGKVDCLDWFYLRILKKDKSCVYIPTSSLYNSVIEIYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM3</accession>
    <name>A0A4Q9LWM3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0656p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000656">
        <property type="protein sequence ID" value="TBU12716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0656p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18451" checksum="2CA091663F1DF063" modified="2019-07-31" version="1" fragment="single">MSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX4</accession>
    <name>A0A4Q9LWX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell cycle control protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0515p0020</name>
        <name evidence="8" type="ORF">CWI38_0508p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000515">
        <property type="protein sequence ID" value="TBU02285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000508">
        <property type="protein sequence ID" value="TBU13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0515p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0508p0030"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="283" mass="32900" checksum="5B39352EE0387DBC" modified="2019-07-31" version="1">MEYFHRLKKQVLTQTLPGRYKERLSYKSLFFYCFLGTVNLILGIILSNTYSQITEIEIPYNNNESQKFSFFVPKNISGTVLFYIKIEDFYQNHLFYAKSLNYNQLEGKNTSKISSCSPLERTDGTIIYPCGLIANTFLQDGYKLFKNNEEIPISTQDISWSSEKRKVGKTQYNLNQIVAPPLWTPYEEVPNLSVNYRFINWMNIASFSSFKKLYGKIDGLEKGEYEIIIDSTFPFGKKSVFISEPSWAGSKNFFISTLFMVTGSFIITISFLLIVRKFVRIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX7</accession>
    <name>A0A4Q9LWX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0486p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000486">
        <property type="protein sequence ID" value="TBU13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0486p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="268" mass="31931" checksum="1ADFE46874C0C36A" modified="2019-07-31" version="1">MMKIESKEEIEKKRKSLAEQNPIFFIRLRRLVKIIFYTILINHVLGFLIQICFDINKSLSTQIRTIINFLLSNFYCLIVFYKKRANENRDYTYFCVNNTNGVLMNLFSIILSNVNDILKEKMFHINRTVGYVEYFFMLTFLFVINSCVVYNSFLMIKFVENNLTKYPANICLTHLISAFLLFVGEKLIIMACILFNISIPKYLSLFMLNLIIFFLIFVRCIKISYQFANRQDLLFAPKIKKLFWFAIQIIAYSYILNCIYLWNMSNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY0</accession>
    <name>A0A4Q9LWY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0792p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000792">
        <property type="protein sequence ID" value="TBU12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0792p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="553" mass="62356" checksum="F286469BA982D04F" modified="2019-07-31" version="1" fragment="single">MYEDNNKKSLNEKSNNRKNMDENESQEDKKDKCGGECKHDNTKCKECCGKSDSKLNNINKNNVVKKVCDDSKDSIGTSKVKKKRTLILTCKEENLVLDSEETNVENESDQSCSKCGKEKTKNKMCCKCMKKVEKRVIRAALSTPKLKKINDDFEISAKKKLYETFVSESSSYEVSEIHSSDSEEWGLDYIEECIEKIKPKKEKIKEKIITKKADVNEDKKFDEDTESFWQHSDTSKIFSSFSEEEEEAEIRSRSKASTDPEISDLLRGENIRDDVFTSSNLSTQNPIYQSKESEENRSFISTEEVDVESFTGKNEKEEESLSNNKTPNIILYGSENLKIQDKKDTESDHDLTSTKENGERLKNEKEVETIKTEKKEEKEEDDAKDDSKNNVKPEEIIFIEENGNGKILGLESDQENENTNVITRNEGFSGIFTSLGLFFAGASIATTAQKNEHHKPSRDTQSSPELLDLLDSDSLAQNSDENNSNNKNIAEEISSSEKSASGANGSDENISTKEVSVSMAEVKKEPGELLKNTNIYENVDGSSLSDATKSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV4</accession>
    <name>A0A4Q9LXV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0422p0050</name>
        <name evidence="6" type="ORF">CWI38_0517p0040</name>
        <name evidence="5" type="ORF">CWI38_2115p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000422">
        <property type="protein sequence ID" value="TBU02744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002115">
        <property type="protein sequence ID" value="TBU09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000517">
        <property type="protein sequence ID" value="TBU13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0422p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0517p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2115p0020"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU02744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="281" mass="32225" checksum="FCF22DE452723287" modified="2019-07-31" version="1">MLRRRNIGFSIMVAGPKGIGKSSFINTLFNREIVQVKKKSNENLDLNLYILEIDCEGVRKKVTVVDTPGFGTTLDDSGTQENILSYIRTQFNMFLAEETKVKRNRDFEDTRVHALLYFIKASPHGLKKTELAFLKKVNGLVNIIPVIGKADGMAVDEMESIRSRILDQLKTCNIEIFDILKDELINQSLNWVNLISKFPFSVICDDKIDGEENTVRGRKYRWGNVETDNQEHCEFSLLKEILMSSHMDALIETTVNDLYERYRTKVLSEILPKADLNNKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF0</accession>
    <name>A0A4Q9LYF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0576p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000576">
        <property type="protein sequence ID" value="TBU12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0576p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="418" mass="50182" checksum="CDB2EF08602F2CEB" modified="2019-07-31" version="1">MENNRKQWIKELETNLCTYLYSYVDNIQRQFIENSKYDLHLLSIAQGNKTEDLYFKILKSIRMKEFFCKFLIASYSMKQLLNEFSIFSFYERKTYSIMRIPNKIKETTKSSGKFCIFSNRFALSLISRYIRHLWEIYSKINSILTEYELISIIQPIEYTEYNIYTITEILRSNKNFYNSNFALVLENKYTNDMRDSIIKSEDLVPTKIEKYEIYSLQYFQITDFFARIKKEICKISFLCSDLNWETYMKPKNIFDDSNSYQYYSTDSDYKYQDTILKMKIYKFSVVKDFAVITSIQNIKEIGLCRFSTNNTSKKNGKHVQSLCLYLFLYKIDISKSYYPSFPYISLQIEYDLKIVVNINEKMYPDDIIYKIKCLRNFATDNYSIKSIQSNVESENITSEKKKLIEIFQNITAEQERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK6</accession>
    <name>A0A4Q9LYK6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-c protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0605p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000605">
        <property type="protein sequence ID" value="TBU12850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0605p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020229682" description="Fam-c protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13816" checksum="1E854F2308B59507" modified="2019-07-31" version="1">MKFFFGFLIFFNFLVDNIFCAISKNDDNDALLAKTSSYVSRDEERVLFNETYSGKEQQKAAKSENPYIKEDITDSKKILGCCWSKKKKPSKTKNKYKELDQGSFQTYRRASSFDDIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX3</accession>
    <name>A0A4Q9LYX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0263p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000263">
        <property type="protein sequence ID" value="TBU17923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0263p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="33749" checksum="5444873BBA4FD643" modified="2019-07-31" version="1">MKGRKRLILVGVILVLIGFIILCSYIKIIRLDNIESYYLEDLEKANNAFNNCNSDDMKDIKKRLCFNLKKHRILHMAVYKIGYLANDILYILDRNLFCISIPYSIVKNCDECFATKSEDVLMKQINRFMNRSMKTQEEYRKKKFEPEESNVNFWVKTIDRTKGTKKSYFVKLIEKFRNKKFMHFNYKRFCRFIYEASKPLQKDIFKNFYTYDQNWCYLSNRSSYCVFLKDKMVFYILKDAKSDGEFIEKNYEIKVLNFKFDTSTTIDLVACLYKALEVQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC6</accession>
    <name>A0A4Q9LZC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0224p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="8602" checksum="83E516F5FA518523" modified="2019-07-31" version="1">MHKGLRILMKQGEEKYKFVRGIRDLKEKEIKEIEEIEEIEEIEEIEEVEEIEEVEEIEEVGEVEEIEEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE4</accession>
    <name>A0A4Q9LZE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0221p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000221">
        <property type="protein sequence ID" value="TBU19105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0221p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="21475" checksum="1E3AE2E37853ACC8" modified="2019-07-31" version="1">MDDFPLMFPKESRFGDKNDQNLYISANIITFEEFFYFYKTLLEFPYLIDNLNEEKYLLFMKILNIFKFERNSFFKNLIRFIWCSVILNYIPIKERNFTSKKLQNYDLPKYIDLSKMVLVEILEIYKFPKGAIGIIKGISWAKNVKKYYKFDFINISDKFLYFDTNIIREFKQGKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN1</accession>
    <name>A0A4Q9LZN1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0308p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000308">
        <property type="protein sequence ID" value="TBU15714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0308p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU15714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18240" checksum="D21209CA55AB90AC" modified="2019-07-31" version="1">MEESILERIRLLEEILKEVKDKETVKEILSQKYLMLNSENVYKHINNEQNVDRFDEQKIKNSSKKDLTKYLYSVIEKSREYKNVVENFKECGIEISGIKSNNVCPITLKKIVDLYVGECGHKFERIAVSELRKQNRICPVVGCSKVLREKVERNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ0</accession>
    <name>A0A4Q9LZQ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0135p0010</name>
        <name evidence="2" type="ORF">CWI38_0208p0030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000208">
        <property type="protein sequence ID" value="TBU19508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000135">
        <property type="protein sequence ID" value="TBU20082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0135p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0208p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="254"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="37920" checksum="E315A694148686C5" modified="2019-07-31" version="1">MKEKNNFEDEKARNFGIKINEYPSEKLRFSENTIRSVMPENDTRHGLDVLCDASVIFEKKENDEYLKECSDYVDNKIHYSRSYLCHKNDANRSKDNVYGCFIDSRNPSINEHRHEETFPSNRNLRNFDLNKFDEHLFRKNGKKILIYSNDNLNIKADCKKEYNYDYTSDKNEYMKYRNKRKPYADFGSYNVINSQRFRDQKEEMEEVFRQLIKYDPDFRDVNKNFTHLKKLISNPDIFINRKKRSGFYEMTAEEKKSKHIKSEHMRRDILNNCFMALKEVLPEKFRCNNKKNIILATIRFLLLLRLEFFSRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M026</accession>
    <name>A0A4Q9M026_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0294p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M026"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="632" mass="75439" checksum="E777257FDD7AF315" modified="2019-07-31" version="1">MTIVKFYNILYFLEYLRVTYEDILQKCLKKILFSLAKAKEIQDLDMDKISSHFPKQEIFSVEFCKILFQVYFENFFSKGKNIYSEFFKVEVETFEFTYEKLYTEDSMQCLIINEKIASFITQNLDNNLVNKNLFILLLNTFDVKYLHIENMKDVALEGYCFILENLKKNIDEIVFNNVSISDQLIRSLERNLNFRNLKKIVFLKSIYETKLQFSEEFSKGPKFIFFTGIVFKDEDLPTNSNVSKNLNTIKRIIMNSKKGKIMNWLFPLKNVIPSRINVERKADNLYLSLFNLELSEEKIKIFDSLDLIYDNWRLNCYYELNGSFNYVFITFENFELKNFRISDSVLPENIRKIVIKNSKIYCNFLKTIFRIPKLKHLSIKESEIYMENEFKIQSKSIKHFFFQMKKEKKCQHFYKLTKLMVNLKEAHLSYYNYIELIFLKNQKIEVKGLCIWNSSTEYFIGIPLKDSTLESLPYKNNNLDFESSSGHLKLLFEKYNFSRIKKLYMMEFSIQASDSEAFGDLFYLKELTLQNIVFKNISFSQLFCSNKEYKIERLSFTKIHIDESALKFISKLSQLQFLRLDGCDVHSKASSYITFSSLKHLHIVLWDSNDDQWKKFIQHILKEFGAERITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M095</accession>
    <name>A0A4Q9M095_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0275p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000275">
        <property type="protein sequence ID" value="TBU17645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M095"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0275p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020198492" evidence="2">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="410" mass="47330" checksum="BBB2A1D401C0DCF3" modified="2019-07-31" version="1" fragment="single">MKSLFKYIFYVFVYIFAVASNETNSTLNYITDDKRDHPCKAIASHKTQSLEFNDFNSISESGSVMMLNHDLIDDLSTSSQTSFYQLADSEFPDIFLDFSNLDGFEDFQVFSLQDKSNSGEHTIANASLHPTDYVSSTFSGSPQSTSQKFTQKKLSSDNRVIKKNIPRPGGSKDRKKSQKGQRQIEKSIGSQSNFATRHKHKPVYAHKKTPSNTSMQKVSQKHVKINQHTSIENSHIDPVRLESVRQGNFNKELKFAELFKSRVIRWIEFEHEKIGCVNYNFFLSKIPDLYSEIDCGFGMGIIFNTIFEKSKNDLMHGNYTKIISEKIEQYNSTAIENEETLNEILFFANNLIKFEEKCLQGLSSKEILSEQKITEIMKTIKDHKNLGVFYELLKFVNYYYENLDNYVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D2</accession>
    <name>A0A4Q9M0D2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0139p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000139">
        <property type="protein sequence ID" value="TBU20059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0139p0020"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12272" checksum="46526CC8C47D135F" modified="2019-07-31" version="1">MKVKLLKIPTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLNKTVETISFDRHRGLDASLGVIMRAEMHEEPTPPLKEEKREKYGGITLEEPTNNINEESDLEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N9</accession>
    <name>A0A4Q9M0N9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0341p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000341">
        <property type="protein sequence ID" value="TBU13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0341p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="83329" checksum="9487AD366FEB5658" modified="2019-07-31" version="1">MPYNNKRNCFVYRKNNYINFQVLNEILLSNTIGNKYKEGIFECNYDLSYFLRLSKDITAIPDEITEYKFKCILLTLHHLKGVENKHLVKFFWALMYKTCNIRANKYKRRLFKFEEIFDPEFSSLIDFYIKHNLVRAFLNNYMMKYICCDGNIVLLDNDNESFDNSLFDEKIPYKNLLINNYKVFCKLENILRNPNTLNCFQTLLNELNMKSLIINDYKARETSDINTDFYIFSMHVYKSIIIVDFVRTHSSLFLNRVNDLIERNIEYLSLLNFIVYRAELISILNKPKLKGLVLNYVNTLENIDFVEDFIEFSKTLEYIDFREIGIYFTWWYNIFETTNIRKIILSFSNLFTQKKFIIEFCRIELYKNILYLEIMFCNVGINTEFFVSLAHFKSLQTFKVSRFKTTPTTEALLSKAIVGMNNLVCLSIQQYSISSNFYNNLFKMQQIKFLNLINFDLGKYILRISFFPEYTSVIRINLMSMNISRASLKEIFKLENLIDLRLKCCFFQPFSDPNFTIFMSRNIRALDFYGANLKDIKCVSILNNLSCVESLDLSDTGLPPGYLVNLSSNCNLSLRSLSYELNILDKNDLSRIEKLVVLEELKLSKCKLLGCSFSEIGDFCGFFNSLINLDLEFVEIKIEDFQYFKRFKHLKKLRCRHFGFDLDVLKCFFVSSNINKFSTDNIDEETFNSSLGKILYEKNIDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T6</accession>
    <name>A0A4Q9M0T6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0203p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000203">
        <property type="protein sequence ID" value="TBU19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0203p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="554" mass="65386" checksum="940293BABACD1055" modified="2019-07-31" version="1" fragment="single">MIYIDLIYMMYFLDLVRGSDVNDVRRPPSLDFIFQNNQYSRQIMRPRLYSLFHSHGTSQSYPSDTQTYQFNPRSFFSDQQSYFTTHQFRPSEQELHRLKRPNDLSDQELQSLNPQPHHFDQDLQSSDEQYCLRNSNSSENNQISSHVAANCNKNTNFISESPPHNSSSYYQPKNKLVRNLAQSYRPAIIFKLFPFYFQSNSTIEQKALTDVKPIQTTHFTQPTSLIQNENSKIRFEENSLGFFHLICNSLDNQQIKKDLDVKYEDHKYWSLREYNKAKISNNVSSGSEINELDECKPFLESNYEIFLEDISHSKEEIAIFSKNMEMYTNSIIENESQKIYSGEKRIPELKNSIFRVFVKKGLPMIYLKPIFLLLPYWVKTALNENNSKTINVFYLSWCLKVIEAVIEFYSKDLNIYISDGSEGNKMKEFSHIFSFNITAFYNSYNFILDYLKNICRIFKKQYHERFFEVVSDVDFLYSHCEEVLCLEYTYSLIPGMPLISLLPKKQVIPEIAGILFDVFILLSDESLKTINIKILESNYLNQEPKNQYKSFKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U1</accession>
    <name>A0A4Q9M0U1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0101p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000101">
        <property type="protein sequence ID" value="TBU20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0101p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="238" mass="28260" checksum="50282A1BDC5E9668" modified="2019-07-31" version="1">MYYRACIDVFKDILYNMFKDVIGSKYTKPEEINEDISVFANKLNDRIFMNKLKEMKQWNSKKLTMKKNKYDIKKLIKDISEHEKISKFVFEQFSNGRFGSCLESEFIDSLNNCDEIKFSIILESEYLISVFIRDLIKKIGETNFLQMFSSENFSKNEQLALKHIYKQIESIEELEPFKSEISGSLTQYLNFLKKDVRVVFAFRKLDERLFSFIKNEILTSFVSKATNESICNKIFQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M164</accession>
    <name>A0A4Q9M164_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0320p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000320">
        <property type="protein sequence ID" value="TBU14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M164"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M164"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0320p0020"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="7">
        <location>
            <begin position="131"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="5">
        <location>
            <begin position="305"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="47147" checksum="2F561BC595952E16" modified="2019-07-31" version="1">MYFTKKLRNLNRFGCNNVHPFKMQRNHSISTEKEIPPNYELRLEISEEKQLKITVLQGNCEVKGQELLLEKTYLFSSIKTFLYTFTGCKIKLEGSYDVMYMSAQTNVPNIFKFFMSQLSEPTFEKILVIGKGRSTFSTILTNFFIRLHRKVLFTDLDPQCSNIIFPGTISSTIVDKLIDYKDGISVYQPLVYFYGNTVLNNLEYYFLLLQELQNAIIKKSHIDIHIFICPNNISDEHFKKICNIFEINKVIVVGDERLFSFLEFEPKINICQSNGYIDALNDLNYNFENEKISKYFYGSDNEYTPYSINLKIGTNLSVVSICEENILPATALPLGTVRKAGFGEIKDVRPSIGSVLAISDSDRRDNVHISPVIGFFVVNSTDTITKVLAPQSKPPKASFLIQGDIKYTGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K0</accession>
    <name>A0A4Q9M1K0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0047p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="44990" checksum="8510B23F0DCBF256" modified="2019-07-31" version="1">MKILILYVAIIFSGSIHKKNKNLNRSDLQQFKTNKNHLIKQEKARILEFKQKNKEKTKLTFQIKEKETKFNKMEILLSKPMKQYEKSKQQKIKSSGAQCSEENKDFDISDNLKVFEQINKVQIEISKLLFELITIFSSKKSLTKRLAFLADGFNDRNELLFNLNEEETGILNEVYKRFDEIKKEALDDEYKFKIYYEKFKRTILNCETIGEMNISKEKTTDANKYYKKDSKSIRTKNTDLTYDLNGVDDIMNESPSILTHSSDSYYSVETTNSPKKKSPCNSQAIISPSTPSIKNSLNLNSKNSLNYKELEQDIKDKAPQALPISAKSISPKNILPTKNITAGKALITLSDPSKNVDRFETVFNHSYEVGAKKEYIANLKLKKTQKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V2</accession>
    <name>A0A4Q9M1V2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0263p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000263">
        <property type="protein sequence ID" value="TBU17925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0263p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="45425" checksum="BF384C39BCDA42F4" modified="2019-07-31" version="1">MHLCPGCKECLYLPRTELERSLHGVELRSEYMLLQLLDCLEESKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRDEAVFCYIQDRNVFWGADDHLATRCEKMLCHDYTRRHNEVVRCLHLLLLNRYKSHSVQEILDNEYAEIRVDSRIKTDIKIRNNRPDIFFLDKKKNKITLIEVGITSQDSLQIVKTEKLRMYDELDNDVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVETYIQSIILKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAGINEEPKPFLKQTSREEDCVKTENKKNNTPLISQEESTLEEPTNNINEGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W5</accession>
    <name>A0A4Q9M1W5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0163p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000163">
        <property type="protein sequence ID" value="TBU19958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0163p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052941">
        <property type="entry name" value="StomDev_PlantInt_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004:SF70">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE ERL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004">
        <property type="entry name" value="OS01G0149700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020339873" description="DNA-directed DNA polymerase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="93154" checksum="40C0558DC33807D1" modified="2019-07-31" version="1">MSYMNMIMFMIVCRWFFASTCCLKGVKCATPANNDRIKFGLIDINWRDMISVEDLASVEYWLSRPMAGEKSCLCSGNHFFIEHKIHPKFFVCSLDIAFENHEPLHIFEVDYRDDWNVRFRVLNEYLAKNEKKPFVFKGSFCVTYQLFNVFVKYMKCDSIITGHNLSYKLFYRLIKLIDLLDPVSSECLNEFYTKLYQNGLMNVSAVNILKDPKNYRIRYFKEKRRQRPFMYFLGAINESLNACLIPDTSMVSIFQKKNQSIDQCFRYTESVHRLVLKISANSLEILMAAITDKMRVFNWLLTVTKISGYFFDNTEYTFNPIRYHNICGFLNSDAPKKCSPPLKALSYDFFAYLSDENTQRISYLKFMNVEIDFDLIGTLFGGNILTDFEVSFCSIGKSQKITELLTEMPNLNVLILRGFEIFPDDVENILCSKIRLLVLYDCAMCQNSIWKPQKNLVSGYEILNNLRTLNISYSRLPFNLVEFLLKSVNLNDLFLNFFEFQPSVLTFSVLSLKRQWDRLEMNGYVPNDYLSKFFIENSVEVLSLSQIKKFSDVRFIFFVHSLKKSVISLNLSDNSMESKDFELIDNFKNLEKLNLASSLPLDISNISDLRIFELINYLDISRNIVGLGNSGFICSFKNLSSLSLAGVKIEAELFKSIFTDVLCDSLVSLDLSGVDLCSSGFQRILNCKKLEVLRLKVSAENSLSYYCDCLLSTTARHNLSILNLEFEERIDFDDLLTLAGFSNLYEAKISCSEFVGIGVDDMKECKFKNSNFRLELCLSEYNVDSFALQVLCDMFSKYMVSIVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z4</accession>
    <name>A0A4Q9M1Z4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0025p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000025">
        <property type="protein sequence ID" value="TBU20764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0025p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="12645" checksum="FA9D7F9BB2F4965B" modified="2019-07-31" version="1" fragment="single">MLLATGLLDYLYFESLGISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M208</accession>
    <name>A0A4Q9M208_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0246p0030</name>
        <name evidence="10" type="ORF">CWI38_0248p0030</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000248">
        <property type="protein sequence ID" value="TBU18232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000246">
        <property type="protein sequence ID" value="TBU18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M208"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M208"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0246p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0248p0030"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="106"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="480" mass="55116" checksum="41709A288C13E113" modified="2019-07-31" version="1">MNSESVSMSTYISTYLSYFILIIYGHIRDRIGKVFCPKKYKKFYRENDMAPLYTDLESFFVRRLYTRIKDCWNRPITGVPGRIITVLERFSEDENETFKFTGNKMDLLNFASYNYLGFSTNEGEITRDVLETVEKYPVNFAGPTNDIGTNEICKELEKEMADFLHKEDCIVFPMGFGTNSCNIPVLMRSGSLVFSDELNHTSIIYGTRMSDAMVKTFAHNNMKDLERQLRYHISQGQPVTHRSWKRIFVIVEGLYSMEGTLLRLKELVELKRKYKFYIFIDEAHSIGAIGKTGRGICEYADVDFNEIDLLMGTFTKSFGGFGGYIAASKKIIDYLRIYSDFSLYGEQLSPIVAAQILSALKCLKYTEHGRNVRRRLEENTIYFREKLANMGFVLFGDTDSPVVPLMIYNPGKLGEFSRLCMERKLAVVVVGYPATPVISSRVRFCLSGSHTHEDIESALSIIEYVGKKLGMNILKKKGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P9</accession>
    <name>A0A4Q9M2P9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0191p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000191">
        <property type="protein sequence ID" value="TBU19831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0191p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="67" mass="7861" checksum="41E89D80D6F435D7" modified="2019-07-31" version="1">MDVEEYIQIDSVYDDGRSISFDRRRKLNASSSVIIEPKQLTMNINKESVLREEQIDVKEIEENMSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3K0</accession>
    <name>A0A4Q9M3K0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0133p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000133">
        <property type="protein sequence ID" value="TBU20096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0133p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020790793" evidence="1">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="283" mass="32376" checksum="58BCC2D992E41F5F" modified="2019-07-31" version="1">MKELFLLLVSLGNILHIKIIESNDTEDSTKGVSQMNSLVSSVKNSSLNITSNSIKAGYLKRSIIYNIEISDVLLNSLTPLDINYDEKYAIIDFQNDLLNSKKLIIKRLILNFENKNVFFISKAEELTFQSCELGGVKYLSDYDYYSDIFRISKYSFTSVEYGIFNRIPNLKNLRFRSCLLNLNLHLIFGAIYPDSIIDGIYICDSEISGKDIKYISTLKVKVLILIHTKNTLSEVSNNLCDDVIKQTLDGLKIKVNVKKSEADNFDKNKFLRFFGGLKYFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3P0</accession>
    <name>A0A4Q9M3P0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">CWI38_0111p0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3P0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3P0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0030"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16270" checksum="21A99F3DF2E85B5E" modified="2019-07-31" version="1">MKLLVTVGSTSFDLLIKKIVENIHILQKKFTKIFIQTGETNEKFNKIENVTIINYKYPLPIDIYDVILTHGGTGTILESLFANKSTFVIINENLKHNHQSDFVKRMEAYIHVVSLQNVIEMLIQDNLVPKKKLQPSKELLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3S4</accession>
    <name>A0A4Q9M3S4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0082p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000082">
        <property type="protein sequence ID" value="TBU20372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3S4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3S4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0082p0010"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23108" checksum="F9A19735B557748B" modified="2019-07-31" version="1">MSSVLKHNKITEMTVNLPAVARKVSWKRKASGAMKKLKKFLQKQFNVEGEVVMSPELNKFVWKGGIEKVPRRIRIRVERCTSKKNVEKSALRVSLVLVGSFKGLNSERSDKEYNLNNIRYIKLVSRIFNENIRDATIIIKDLENYLKKISETERFKKCVIDLKKSKTSAFSIENIYSCFFMFPYFDGVGDLNILLGQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4M6</accession>
    <name>A0A4Q9M4M6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0007p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4M6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="415" mass="49397" checksum="5068EAB369C5D78C" modified="2019-07-31" version="1">MLNASIKQESKYFLENETKIDNILDILQYKIDMQHMHNFNGLLEIAGMEYLFLNNEYSDLEILSNDISNFWTRSYSGDMKITCAILLYTNDFEFETRFLKEILGISKNIVEFRFPNKTVHFNLLNLLYRPIGRRNSKKYESKDYLKIMGRKTIIYYSCMMHEILSKFSYQTKDHSMSFFPVFHKKLDDKYYQFFYNFLTQVLSLFSERKICKGFLVAGNQKLNECYFDELNKFDLIPYAFSTEFYKTGRNLSLSLDAMESNKTLDVSNDFCNHNISFKLLKILEPENKCFKFTNKFSSFLKKTCKSADKLRFEYFTIQYYIKDMSLEFELNPDPRDMNLLPDKSAVAISLISDGIGLYFKLIFNLQTRELLDIEFDESQIKEKVTWSLKNKKKYLSSVFNKTTRFALIWDLRDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M509</accession>
    <name>A0A4Q9M509_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0039p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000039">
        <property type="protein sequence ID" value="TBU20656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M509"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0039p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15487" checksum="AF7C5EF64BA88837" modified="2019-07-31" version="1">MKENIRSRDEAVENRITLIEVRIISSHSLQIVETEKLRKYGLLENDLGLIYRYNGNEQNTLRHMLKDCKYSTQEDGETILLMDEEDLSQDQMPKNAEKERTNHSIKETTVMQDSVKHDKKIMDPLFHTEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5D2</accession>
    <name>A0A4Q9M5D2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0004p0030</name>
        <name evidence="6" type="ORF">CWI38_0006p0100</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5D2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0100"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30850" checksum="B5D0319A545A4809" modified="2019-07-31" version="1">MSERVELNLEKMMNELNDYLKRGIFDKEEIKTIVTTRKRHEYKLNRSEKQLIDFLRYIEYETILEKIKDKRMTKLNINVSSNDNTLFKHILYLYKSALIHFGEDKKLFIQFLRYLTKKRCLDKIKTVMSEHCARYPLDADLWIFCAEKYFAMNDIENCRKLYQQAISLNKKCFKLKIEFFKSELKYVNSLIETDEENGISYQEAVTLQNYEILISIYRELSNLKPTKEIIDELMDMIENNPILTNKISQIKSIEIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M600</accession>
    <name>A0A4Q9M600_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0001p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="437" mass="49749" checksum="CEFD99E8DBC93CF7" modified="2019-07-31" version="1">MNVEIEQTNVVDICETAGNVVTLLNMPEQRTQESSDIGIYHDIIELGMLSTNRPAESSIVNTMATTESQDEAKNETNFTTLKAMIATNYHKYSPTNFLHNLQENVFIDSFIYMMLWFCSIVVIITVLNNLLFVQSHSFLIFISSSIESFDQTIGKRVFRMESSGGEVEAEINTNNLKYKFVEHVISDSQPNPSKKTKRNRKAFEKKTGKKPIKKIHPKVLNCIEKIAYNTNPQTKEFVPRNSLTENAPTTIGLEISQIYNQIILTGTIFLPQNNYNLSDGSNNYVLLTGCSLQPQSTIYYNLISHQNLNIPTLNEGHTTEQSHYAENQTCNIDNSIMNCDFFTEQAQSIFLSYLTLNYSLINSEESFLIIKEELCNIIYPSNIGEIFDLEYFLQTDLNSKYVFLDVENAILKIDPPDLEMLSDFKIVLGIGKKTCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUT9</accession>
    <name>A0A4V2JUT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0696p0020</name>
        <name evidence="8" type="ORF">CWI38_0023p0030</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000696">
        <property type="protein sequence ID" value="TBU01492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUT9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0696p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0030"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU01492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="103" mass="12412" checksum="DE80A603991E615D" modified="2019-07-31" version="1">MHENKKTNFLKEIRLMMYGYGDVSNPRQDTAEVLQDYVLDYLRNILIKTQNMAKIKGKTKTDDLLYILKRDTRKYRRAKDLLKTNEELKNARKAFDCEEYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWE6</accession>
    <name>A0A4V2JWE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2370p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002370">
        <property type="protein sequence ID" value="TBU07652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2370p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9902" checksum="3460BB4549147410" modified="2019-07-31" version="1" fragment="single">MLLQLLDCLEKSKETSTRRAAILKVENDNKTHLALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWZ4</accession>
    <name>A0A4V2JWZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2112p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002112">
        <property type="protein sequence ID" value="TBU09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2112p0010"/>
    <dbReference type="OrthoDB" id="10565504at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="12148" checksum="951CE89D917AC0DF" modified="2019-07-31" version="1" fragment="single">EDKKNLASNIYIRSRSEDLKILFQERLAMDLCVGESYGNNQIKYLKYLKIPSYIKEASVVFESVREDPVLIGACLAAKIKFIDGQEYTRREDFFSKDYKDLTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX82</accession>
    <name>A0A4V2JX82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1548p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001548">
        <property type="protein sequence ID" value="TBU10792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1548p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="27865" checksum="44951095D2D7FF56" modified="2019-07-31" version="1">MKLLNKTAVRISLTIFVAIATVFLIIAIIGNKKANSLIEEFPNEFKKDVKLYEFKELSSALRTSKVAAFIAIRNSNEGFFMFDFEYCPEVRDYLLKALDTKDKEFFLKGKRPNEIYKCESVDFEISSKAIANIGFVAKIGFLFKGNQAVKTFNEISGFIHKRISKNIKCEFKLVILSIPDEENVKAYEVIFNQSEEFEFGSSKSFKFEPNKDINADSYEYVSSLIIKVTKGKFTNMKKYRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA0</accession>
    <name>A0A4V2JXA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1431p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001431">
        <property type="protein sequence ID" value="TBU11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1431p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="6618" checksum="57CBCF4173D8B035" modified="2019-07-31" version="1" fragment="single">PPLKGEKREKDGAKNFNPKNKAPHISQGGTTLEEPTNNINKESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA6</accession>
    <name>A0A4V2JXA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1390p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001390">
        <property type="protein sequence ID" value="TBU11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1390p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="47824" checksum="61819DC354C00D82" modified="2019-07-31" version="1" fragment="single">HAISLINYHIGVLRLEPADFSKLDEAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKKGNIRPRNEAVFCYIQDRNVFWGADSMCQHCEKSGNTVDLLATRCEKMLGYDYTRRHNEMVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEFAEIRVDTRIKTDVKIRNNRPDIFILDKKQNRITLIELGLIYKCSVELIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFVRRRGLESGLNAEESGESEDGAKNFKPKNKAPFISQGGTTLEEPTNNINEESDLEEETIVVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB2</accession>
    <name>A0A4V2JXB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1412p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001412">
        <property type="protein sequence ID" value="TBU11052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1412p0030"/>
    <dbReference type="OrthoDB" id="2194794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="41"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="222" mass="25841" checksum="63557641FBBE2FE5" modified="2019-07-31" version="1" fragment="single">YTLKRVTLVPERRNTLSTIELRTNYATSFRELEVDNDDKNFVFLDEVGFAVVTRPSRGRNMRGESAYLSVTAARSRNISVVAAMNKYGMIYYKIHERAVNGEDFKLFIKEINESCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVFSVWKNKVSRGGARTEPQLRILIYEKFNEITGEHCSSFYRKMLGYLQKAEVGQMILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC9</accession>
    <name>A0A4V2JXC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1267p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001267">
        <property type="protein sequence ID" value="TBU11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1267p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10809" checksum="B452C2A05995D512" modified="2019-07-31" version="1" fragment="single">TNIKKELEIYKTNIIDWIFKYFNGSIEEFLFYLIIESIETENEDFFLYEIKNYIFEKPDKTKLREYFLEFCILDEWKSKGLNLIDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN5</accession>
    <name>A0A4V2JXN5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0717p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000717">
        <property type="protein sequence ID" value="TBU12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0717p0030"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19840" checksum="EE31CB8BBD0EC75D" modified="2019-07-31" version="1">MFEEDRRDIAMEVNIKKNSIMRGYFISMVETYGSFSAYIEIKNEFLLNNSYMKFNDEIHFSFSSKDKPSDFIPRIEFTYETSEDTFDKINAKNVSIDPAIKTLSKLRNQLHDVAKETKTVMKCLNEYSINFENFVVVSIYIYFLAFLCSSFVYAIRIKNFFKRKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ1</accession>
    <name>A0A4V2JXZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0381p0040</name>
        <name evidence="1" type="ORF">CWI38_0474p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000474">
        <property type="protein sequence ID" value="TBU13299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000381">
        <property type="protein sequence ID" value="TBU13612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0381p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0474p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17268" checksum="287A2010BB29C645" modified="2019-07-31" version="1">MITLIEVGITSQDSLQIVETKTLRKYDFLANELGLIYKFSVEIISYVMTWDGIVTKYHKSHLKRLEIPMNVDAYIQSILSKQMTVESIFFDQLRGLSSIDVIERDEMHVEPTTHLKQASKDKMEELTNNINEESDLEDETIVVKEVKGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY25</accession>
    <name>A0A4V2JY25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0261p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="51567" checksum="D572CA1121BC7ED9" modified="2019-07-31" version="1">MRRLKYFLFKIWMFNLYLEGKMDIAKKQKFFAKKCLDIYKRETTAFELLPKAIDVTHLLFYQNIPELTVKSISGYLQSGISKKYEFLIYGTTKYSDDSVREITFKTLQITQLNKKNWFLFFSNIPLLNKLSIQNHSHSIIGNKCLTYFLKYFFMIFKVTKMLMKYQNGTLRKYSYVSIDDITNGLSRKIPDCYQNIPSNLKYDTFNLLCVKIFSENVISEHTIDREKMINQFNRLFDESKSKIFFGCYNYFLIYKNNSEIHEETDIHKLSYKTIINVYQIVFDDLQILEGGAKNLILLERSFCFKNFSYDFEFMYLFTSKNTKDSDYKFFILFSRDSRKFVFNYKWFMNRAYNDIIIESSFYLAVFAHFKLYLIEFIEEENPRYFKIHRVKCSDFRIKIFDEEKISYLGNLMSINSFIDMLIFYPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG4</accession>
    <name>A0A4V2JYG4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_2497p0010</name>
        <name evidence="9" type="ORF">CWI38_0001p0140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002497">
        <property type="protein sequence ID" value="TBT97105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2497p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0140"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="7">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT97105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="126" mass="13903" checksum="74EBD643141BCA2C" modified="2019-07-31" version="1">MTTVNTKAHPLAEDDLSQKIFTTIQMLNDTNNIKIGANESVKCLNKGRAHLIVLAGDCEPFEISQHIPLICEDKNVPYVYIKSKSTLGKACNVSRSVIACAVFSDTESGCSRCEKFVKDIVKDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVF7</accession>
    <name>A0A4V6MVF7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0104p0040</name>
        <name evidence="9" type="ORF">CWI38_2707p0010</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002707">
        <property type="protein sequence ID" value="TBU05782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000104">
        <property type="protein sequence ID" value="TBU20253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0104p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2707p0010"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12698" checksum="E759BCF26D9210D1" modified="2019-07-31" version="1">MENRRDNMKQLQQYIRKRKELQRSVCNYEKEIFRLETLFLDMTQGFPVTKNLDYYLNFKVEKKKGYNKDKDRIFSRNIPRINEDIVSRGIVRVIVSRGIVTGYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL6</accession>
    <name>A0A4V6MVL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tub-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1085p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001085">
        <property type="protein sequence ID" value="TBU11682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL6"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1085p0020"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="29794" checksum="46C65FD132491E58" modified="2019-07-31" version="1">MADDSSFMSPDFGLSERNFEELNERLTPATENEVYLSHKNIVKNHPKMDVIVKGQVVREKKYFRNRYFYEYENGNNTRNRLLKAEKTFFGFNIYSYSGNTTKLCAKLSSNFTGTTYHLYELEKSVPETMIVKYNMCLFGPKGPRSFCVAFGGIDNFENKSISERWRERDLSSIIFLCNKKPVFNAETNSYVLNFNGRVTMPSVKNFQLIHPQEPSYITLTFGKILSNVFVLDYQYPWNAIEAFSIAITALDFKIGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVB0</accession>
    <name>A0A4Q9KVB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1842p0010</name>
        <name evidence="5" type="ORF">CWI38_0740p0010</name>
        <name evidence="4" type="ORF">CWI38_1430p0010</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001842">
        <property type="protein sequence ID" value="TBT98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001430">
        <property type="protein sequence ID" value="TBU11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000740">
        <property type="protein sequence ID" value="TBU12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1842p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0740p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1430p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="155" mass="17583" checksum="D93B7115FE7B811F" modified="2019-07-31" version="1">MDLIGSLDELAETSFIEMQPTVLDINIIDRTKSNRKITTENNISLVNSEACLIDIPLDEVICNAGDSTENIISSENPRAFILDISLDDSISDKKNHEKEMDLQTNEISKYKKIYKKVYIEEESCISEYKFPITCICLITITAIIITVILVVKNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2E6</accession>
    <name>A0A4Q9L2E6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH/CRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0933p0030</name>
        <name evidence="2" type="ORF">CWI37_2590p0010</name>
        <name evidence="4" type="ORF">CWI38_0144p0050</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002590">
        <property type="protein sequence ID" value="TBT96981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000933">
        <property type="protein sequence ID" value="TBU00670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2E6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0933p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2590p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0050"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="50"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT96981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="193" mass="23012" checksum="FE5A0D8E84981226" modified="2019-07-31" version="1">MRLREHVDDSEIEKLCEEVILDHLIYARAENTAKLFSERLNIKDIQGIDFLKKRKEICDFISKKQIEEAFKSIKKYFPFLFETSDETEKKLIDDLFKQMFIDYVEQGDFQKAINTAKEFLEKNNFGFDPHVFSILGYSDFENHNIKKFFNSERSSKLVENFNEVIYKRVKGHSNSLLHTLLLHYSSVLYFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L866</accession>
    <name>A0A4Q9L866_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI37_0353p0050</name>
        <name evidence="19" type="ORF">CWI38_0040p0060</name>
    </gene>
    <organism evidence="18 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FI-OER-3-3</strain>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="PITJ01000353">
        <property type="protein sequence ID" value="TBU03121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L866"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L866"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0353p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0060"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="17">
        <location>
            <begin position="14"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU03121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="340" mass="39429" checksum="BBBE4CDA9470ED46" modified="2019-07-31" version="1">MDFWQKLQKPIKIVAPMVGNSDLSWRILSRKYGADVCYTEMVHVESFLQSKSDPQNNYWFSTNKEDKPLIIQICGNNPDKMLEAAEKLQNYCNGIDINLGCPQPIAKKGYYGAYLQENMSLIYQIVNKLSNNLKVPISCKIRILETLENTIEYAKMLEMAGCSLIAVHGRTREQKGDKTGLANWEIIKKIKESVCIPVIANGNMSTKKDIKHCLEYTKCDGIMIAEPHLYNPLLFTHLKLNVLEIFYEYLNIFTKNDNFLTLIEVKSHAFKLLRNILDFLPEYRFKIGNSKNILNIINVFYDIIDEILFLENKSILPQLLKSKSYYRSSYIKMKDVYQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCX5</accession>
    <name>A0A4Q9LCX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWWP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2715p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002715">
        <property type="protein sequence ID" value="TBU05737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCX5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2715p0010"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="23028" checksum="CDA9D2E37F5503B3" modified="2019-07-31" version="1">MFKPGDVVWSKYDEYPYWPSRIASKDVTDTLQSYNNTNLGIGVLFFGQNLTYALVEEKNICEFFENYKFYYKASNEEDFRFAIEQAKSNQNIEDPPLELPKKKKRIPKNNKENNTNSQSNTNKIKETLNNILLNYPQNTEMAENTFQELESLSSAQLKTLNIYNEVYLLSNLTFKTDPLSLKERSKNILERWNTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEC4</accession>
    <name>A0A4Q9LEC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2600p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002600">
        <property type="protein sequence ID" value="TBU06307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2600p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="84" mass="9414" checksum="187839F7F82085A8" modified="2019-07-31" version="1">MPKSSGQSFTCTIMKNPPAVTLDVLKILEKNELEKEVKLEENKNRRKIATSVRGYDEAHIPESITDAAHTIQAAPLCYDEATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEJ2</accession>
    <name>A0A4Q9LEJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2581p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002581">
        <property type="protein sequence ID" value="TBU06419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2581p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19763" checksum="E3B90500E1241456" modified="2019-07-31" version="1" fragment="single">MGTNTPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEFDLLYACNINDSITNNYNRDKGELTNRYALYSEEKNVLYECEGLHRFINELFLCPNGKDELKHFELSMVKISFPKNICLIPSTENLIPMSKCRDEIYLHQKPYFIDFKYCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFH0</accession>
    <name>A0A4Q9LFH0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2587p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002587">
        <property type="protein sequence ID" value="TBU06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFH0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2587p0010"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="629" mass="72699" checksum="66DF74B26EF53871" modified="2019-07-31" version="1" fragment="single">MFYSQKKEDEVTWQKINMSYERSKTLTESDFLQFLIQTKDIIVRSMASERSKLSGTTLSLLNNAIIIISKEKNNEIVTKIFSFLDSILPTLIKLTGKSNKVICTRAECTLIEMGKVLSLTRHISLLKDSLSSISKNIRLGVYKLLESNYNNFYLKNKSINENYFKDFIPLIMKGKSDVNFEIRDLCKRMCHLIKEREDIIVEDNEESKAPFSIGSKPRVYRPPQFIQREIKSGIEEKNTKKEIKLPSNYINSYSFPQRNTGFKVSNDVNIMDFKGFNNRGNSTVINNIFNSNSMFVSQNSCKIRKDENLKKTNEEKNFRGENINKNISLNEKCKYDTRKQLFEGKFAVMNKNVKHVMPYSPFKKQPKIVTKRENNFQNFEFKKKETGEHAEIDSKPFNNFSNHLSLIKSEKNVSNENKQVAVSELSFKNYESGVDRQQSIHSFSNTNDSQKEEKLSKLEKKSDKNIFNKFISDNALNKETEGNDSFTEMKSFKLKNYLEDFENDTDDKKLNDSIYEKFGIKVDFQKNPEASDSFINEEEIKIEPPVEKRDESYKSKTATALPLEGLKFDKELAFVETDSNNSKPDLNVPKANAIIEVFNYDNEKNSSSVSLGISHTDRNISSISFPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH48</accession>
    <name>A0A4Q9LH48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2603p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002603">
        <property type="protein sequence ID" value="TBU06290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2603p0010"/>
    <dbReference type="OrthoDB" id="2192627at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="29079" checksum="EF661EB8E971C7BF" modified="2019-07-31" version="1" fragment="single">MKRISDYLKKNNKEEKPLSISRQNSLNEKMTNMLNIGQKKDIKNRKIEKENKNMKNNYKEFTGKNLLKVKLPLELAHCVLCKYNKNFGKLLSGRFLMVYKKTNLKSINRRYRETHLILKSSTSFTQKMIGFVNLKVLDVMDINYFNFEFIEDLNLQKLKIKNVKNISIRKNISRYKIKNVKIEEMYINLIELEKIIQINSLIGITLNNVNINGTNNINESLLQSIILKTQLKKLKIIQMKISEEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI75</accession>
    <name>A0A4Q9LI75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2393p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002393">
        <property type="protein sequence ID" value="TBU07486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2393p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="552" mass="65950" checksum="571057EE6DB20299" modified="2019-07-31" version="1">MNNFTTRYKKRFSGNTFVNNSVLFGYILCLLDTIASYKYVYRFEQYENSKIIFLDMKRQPETYLGANNEDFKLDLLNSEPILDEKNTKIFAYEKDHFINFESLNNILNLSISDRPNGKIECNFDLLYFLKSTKDITEIPDEVNHIDIKTILIGFKYLKAINNKNMSKFIQALIFKIFLTPNKSFLKKNCTYIQGLMDLNFWSKMDFYITKSFISGLLNIWMINNIFRDGNLILIKNTRRYYDFVYFDKHIPYKNISIDSSRVLLHLEKLLRDQIIFNFFQILLNEINLKSLILDGSIQNILSIEFTCLLFSRPIFKSITLYNFKGYSSSNFLMNLGIVCRNDIEFLRFERLNISSSLLRTFLEKKKLRGLVFYNVEIFETTLFLDRYLDSIEKLEYIAFVNVKINSIWWCKLFCKVNLSTLILSFNSIASEQSFFYGFSKFSIVQYTLHLEISFYSLKKPKEFCDSLFYFKFLRTLKLQNYKMNEKTEYCFLRAIENLNELEELTIQQSHLSTKFNDILLKKQRLKTLHIENYFSEKRNLEIVLWDSYKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKH1</accession>
    <name>A0A4Q9LKH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2228p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002228">
        <property type="protein sequence ID" value="TBU08704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2228p0010"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21218" checksum="4C326CAA53E31AD7" modified="2019-07-31" version="1" fragment="single">RNEAVFCYIQDRNVLCGSEDICQDCIKSQILENEHKQIKGDTKIKTDFKIRLGITSQDSFQIVETEKLRKYDLLANDVEIISFGINWNGIVTKYPRKYVKRLIVLNKTSGINAEESWKSGPEPTPPLIQPNNVEIVLNILKQKIKNLKFWIEELNININIESDLKEENAYYDKNILNEKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLV1</accession>
    <name>A0A4Q9LLV1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_2168p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="PITK01002168">
        <property type="protein sequence ID" value="TBU09244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLV1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2168p0010"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="584"/>
            <end position="585"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="633"/>
            <end position="636"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="656"/>
            <end position="659"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU09244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="742" mass="83543" checksum="EF5FF27E716E4EB1" modified="2019-07-31" version="1">MKIENDKIILPSRSKDVNPTIYIPKELHSAFLATDSKDKDNMDKDNKTTDKDNSTTNKDYGTTDKINKNNKATDNTIIQQISNITNLPNIISVTGFPDIHHGYCFPIGTVSVFDLNNNTPVVPEGVGYDIGCGVRGLTTSLTLADIKDKTNELADLLFSEIPIHNTNSKFTLEDINQILDKGVKYLVENKKFGKYSSKDFKDESSKDYKEDLSKDNINKDLIKNNDNKDLSKDNINKDLIKDLSKEQPKEDKPYIIEDLSKIENNGSYKGNSHLISQKSKSRGLNQLGTLGSGNHYLEIQYVDEIYNKEDCNSVGITQLEQIVVMIHCGSRGLGHQVCTDYIKKMKENGKGGRNGGRCGKDISNNISKERYNKNKDIKDNISRDIKDIKDIKDIKDIKDTDIKDNITKDIKDIKDNISKDINNHNLSKDNINTNNIPNNNLNNTNNIVYDTFDSQVSKDYLMAMGSAINYAMVNRAYITMKVTDCLNQMFGNRDKGIRDKDNKNILVNKDILDIKDNKNILDNKDILDNKNVLDNNKDILDNNQDNKDILDNKDNKDISDNKNHTTNNNNNNNVTVSLIYDGSHNSCRLEEYIINGINKEVLVYRKGVSYGLEVGNKKLCKEYKNIGQPIMVGGSMGTYSYIVCIGNKGVFNSCCHGSGRLLSRKEGLKRYEGEGVVKEMERKNIVLRCSSVKGVGEEADGCYKDVVGVVEYSDRMGLTRRLCRLKPLIVIKGSVSNEDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM41</accession>
    <name>A0A4Q9LM41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2288p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002288">
        <property type="protein sequence ID" value="TBU08240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2288p0010"/>
    <dbReference type="OrthoDB" id="2189914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="45359" checksum="09D58DB8D49DF154" modified="2019-07-31" version="1">MLTETKQDTLEKSGTNSDDTAILDFVDDGVFSTIFLVFVLWRIVKSRKFKFSRFFKGNLRSFGIIFLFFSAISKIIYTYIFIYLAKKMIVNKELIDKMGFMKGHSFLYLYNRRFDLVDMFNIGYTLSHVLRISALFLLIGLWLPCAYTFAVKKRKNEIKNLNEQKDINLMIFSGNIVSISPKNIADAVSHASIVTFSTLYAFLRVPLSFIVDYNQKSSFFTATVFYRSVFYGFEIYAAVLFLLILEIKFLSIFRRENSQSRADKNVVENIHLLLIVLLLHSTLKYTINIIAMPIEMGEITLHVIKKIGNVVELILDVLLITMFCPLPTQIFESTNETSVYEKPLWRPSERLEYDKYSVGPIVCEADSPKIDPCERTIVELRDFREEIAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN71</accession>
    <name>A0A4Q9LN71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2109p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002109">
        <property type="protein sequence ID" value="TBU09829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2109p0010"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="310" mass="36871" checksum="DDACB6778F727C84" modified="2019-07-31" version="1" fragment="single">FQNYYAFSYHEDICKEYFNDDILNAYSQILKQRDEQANKMIFNSYYKICFTYLEDHLEKLLSYVTTKPFLEFENISCFLKEFICNPEYSSALRVGPFYVLLSLNPIKSMCYNEKVLVFDIDDTLFPTKLFEAHFNEYEYGFNYTDPDQPLESFMIKFIQNTKEYNESKCKELVGNFFCKEKNSSLFSIQSHLAFLEEFKQELQHLKAKKICFTNATQYHAEYILKQMNLVDCFDHVVHREIAYIDSTILKPKYQAYEFVENFLGTSPSNIYFYDDMLKNIVEANNRGWNAFLVQESLIKVLRESLVGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN91</accession>
    <name>A0A4Q9LN91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2117p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002117">
        <property type="protein sequence ID" value="TBU09784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2117p0020"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU09784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="10807" checksum="A676123D147F1770" modified="2019-07-31" version="1" fragment="single">MQFKRKIPLNSESSVKGNNGITLVIGGCGLYTGAPYFVSLSSLLSGSDLSYIFCEKETLIPLKVLLPEAIIVEIDFHEWILNRVSVCVFGSGLGRPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNR2</accession>
    <name>A0A4Q9LNR2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2036p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002036">
        <property type="protein sequence ID" value="TBU10083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2036p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="71541" checksum="F9C131821FDB4327" modified="2019-07-31" version="1" fragment="single">MLSERLPPPPTFHDTTHQPPSSSCQNSPVCLVDTIPSSSGTDANAFGPANGMKNLNTDAILEGNRLMVLYLILDSVTVRMPRNGWPATLRYYNEKFGCTLDIDAFKKLAQNEAEREIRQEENGERRRIATCLTEPSTLTDTTKYINLRDKFLGKIKEISKNEIRKVVVRTRKHPNELVDSKVLDLINRIIGEYADSCVPMTITEVAQIIQAAQVCYDEATRKEKPRSTLKENIESKISKLVLSKDLLEKARKHLKKIMREFNLNLSSVTDLSEALVKKNESLNQEEIPKENRMFELFRGRFYRGLSEHVESEHVISRDEIVSFWSTMWNKNDDTVTYDDYFIINRLSNWKAAGINGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQADWFYCGLTYLIPKGIPRRGSEYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLGENHLREPALMNIALNKEILNLNLPDWILKFIKVIISKWKIDISGFYKEIVCHYCCLCCTKVTVQTDTESHSTNHLLFIDDLKLFAKDISSLSAITGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKKLFSAINQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNS9</accession>
    <name>A0A4Q9LNS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2111p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002111">
        <property type="protein sequence ID" value="TBU09817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2111p0010"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1204" mass="137636" checksum="ED7D63BD8CF73CB6" modified="2019-07-31" version="1" fragment="single">IDNSIDNSIDNSISSNILDNSIDNTIDNSISNPTNPTLSPITTSNPTNPTPPTSITPPPHINEINELEISGMLYGLGLQGKLDTINHTFIYNIDTTTYQLLTITSIISICISKRSTCDPLLTKYLKNIIFSKPSYSLKYACCIGLSFLFYKSYNKSIFNILIKECNRYGCYYSDMYNKGNKIWYDEYYRVGIGLAMSLVFMREDLEGGGGDVEGGDGDLDNISNSNNSNNSNNKHLDISNNSNNPISNNNNPYTNNPYTNNTYTNNTYTNNTNTNNNTSHTPSFFNYFTLKNNISFIPLKDSLCELLVNGLIFFKSKKKKIINYLKRSDNSKLQEIFYSSFFCKGICFNEEEEDILREVESIYMFSCSDVEMYRISGLLLYIGIKVWSKIGSGGSDVGGGGDVGRDKYRDSRYYSNNKDCSNKGNNKDTNNTTTYTTYTNNNTTYTNNTTNNSYTNNTTNNSYTNNTNNPSTNNTTNPYTNNTTYTTNIKNRLIAICLFAEERVKKNNIYKILLDSSLLSLVIILNGTLDLEVLRILRRILKKLERSKYLNEISDFNIYENGCGYEVQYGLRYGDIVKYKMLLGILCCGMGMYRMRFSCFGVFCVVCSFYVLFPVSVCEQEYFQMYRYFIVMCFEQRYYMSGRECGECGNSNRDKGYISNKDYSNKDKDSNKDKGYISSRDKDSNKDYNISTRDKEINNSFNNHTNTNTNTNTNTNTNINTNTNTNINTNTNINTNTNTNINTNTNINTNTNTNINTNTNTNNIQDNNLTTDPYLLHFNTFNINFSDIDGLNNNNDNFIEDYLNESLCDLEEEEFNFNENMKGEEEIEIYENRSVFRNIKGIDRYSSNGSSSSNSNSGSKVEICECSKSGDSISKGSITRVNNKDNTNKSNTNNNIITNNDTTVNTFDYKQLLVVKNGFYLLKSVLVESSKGFLKDFLRLESYKKKIVLDVLSNYYEENGQKYYSMEIEILKELMCYTLCRDGCRGRDIIKRKNLFSEINQHAISLINYHIGVLRLTPADFSKLDEAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLNSVDKEISTRRAAILKVENSNKTHLALIKGFLKVKFRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKKGNINPRNEAVFCYIQDRNVFWGADGMSHHCNKSGKTVDHLATRCEKMLGHDYTRQHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNX9</accession>
    <name>A0A4Q9LNX9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI37_2127p0010</name>
        <name evidence="19" type="ORF">CWI38_2069p0010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FI-OER-3-3</strain>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="PITJ01002127">
        <property type="protein sequence ID" value="TBT97696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002069">
        <property type="protein sequence ID" value="TBU10044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNX9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2127p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2069p0010"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBT97696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU10044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="350" mass="41234" checksum="6C2475A879ACD107" modified="2019-07-31" version="1">MENYFTFFRKSNLYVRISLTIIMSVFFSLLVSGNKVYLIILVYFIKTFTFKEVISVWNSFRENKKGIFKNLLWYFMIVADIYFVGNSLIKIYYEKIPFFILENFMMIYFVMYIFGIVLFVINLRKSHLKLQFAQLAMVHMTLFIVCGTSKLVILNINKGKFWFVFPATLVIINDIFAYITGKLFGKRKLIRLSPKKTLEGFIGAFVFTFLFGILFSYVRINYSYFGDKLDLVFIERFYIKWLGISIAKIYLHSIVFILFSSFIAPFGGFFASGFKRAFKMKDFGDSIPGHGGITDRMDCQYIMGVFTYVYLHTFIITHKRNVSEMYDYIIRTLDEDGILKITEMLVNRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP67</accession>
    <name>A0A4Q9LP67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1905p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001905">
        <property type="protein sequence ID" value="TBU10253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1905p0010"/>
    <dbReference type="OrthoDB" id="2192073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="347" mass="39918" checksum="2D00784CA38577F6" modified="2019-07-31" version="1">MDYNVITANMKFYGGIFDMVNRDLQPYGVQVRGYFDNLSLDDYKVPYDKTKCMEGSPSQARSAMSRTFIQAKEKGQLGNRLLVFFCPNLLMTPPLTSILPFGTCDNIIGFTFGEIHQLKTSIYDSIFRMISRVKYKDMGTVNTSFNSELCRYTDNCISNSETVYGEYIRDLKSVRHLGTEEYILKPGAKLKIHDPNDDTYFLKAHGDGFRVFPTEDYSNEEELLLDGLSMGKVKDRKISEKLELGIIISQYRNRLGILEFVLSICDRSIVCKSNDISTRLFISYVTNKIINKRLLLLTVIVSDISTRLFICYTVIVSDISTRLFICYVTNKIINKRLLLLELFLRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP95</accession>
    <name>A0A4Q9LP95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1974p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001974">
        <property type="protein sequence ID" value="TBU10164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1974p0020"/>
    <dbReference type="OrthoDB" id="2198921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16512" checksum="1FC46EC67357DC43" modified="2019-07-31" version="1" fragment="single">LRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKAHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESEPTPFLKEEKREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETAVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPR2</accession>
    <name>A0A4Q9LPR2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1767p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001767">
        <property type="protein sequence ID" value="TBU10429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1767p0010"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19119" checksum="71F4D522AE054F83" modified="2019-07-31" version="1" fragment="single">MLGRLFVNTVSLIFILYNTFNFLKLKAQKSCLIKHYHAFFITTSIFLSLDIFLNPLTKIFPLFQVVKLCFILWTSIPLCSGSLFIYKMYICKIFGKYHCKIDDFIENSRLSVVSKIVDTYQRAYSLTSDGLKNNKVINSYVFKDVKEESDTFTECVVYEEETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ57</accession>
    <name>A0A4Q9LQ57_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0159p0030</name>
        <name evidence="8" type="ORF">CWI38_1626p0010</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001626">
        <property type="protein sequence ID" value="TBU10653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ57"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1626p0010"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14377" checksum="C3BBA7F472E4E856" modified="2019-07-31" version="1">MQVFVKCLGQNTITVDIPCKSSSDELKGILQEKTGIVSKDQLLFYCNRPLNGCSLEEMGISSLSTISMTQKLLGGVLSENTRALAMSYQNIKICRKCYCRNGANATHCRNQKCGHCADLRPKKKRKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM0</accession>
    <name>A0A4Q9LQM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1825p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001825">
        <property type="protein sequence ID" value="TBU10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1825p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="17035" checksum="EE3D3C450C08BEC5" modified="2019-07-31" version="1">MVTYFRESLASMNGGGGDPKEKPTEPAKDASVKPAGNPGMQNHTGPASSGARAEGCRGDNARAGADSAKAESCRGDKARADSAKAGADSAKAESCRGDSARADSAKAGSCRGDSAKADSAKAESCRGDSAKADSAKAESCRGDSAKADKARADSARAGGHNHGNCPYHGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM8</accession>
    <name>A0A4Q9LQM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1817p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001817">
        <property type="protein sequence ID" value="TBU10366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1817p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="231" mass="26873" checksum="710920DAC9178DFF" modified="2019-07-31" version="1">MLGHDYTRRHNEMVRCLQLLLLNRYKSHSVQEILDNEYPKIRLKFRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIILYVMTWDGIVTKYHKSHLKGLEIPMNKTVETISFDPRRGFESGLNAEESWERASMGVVKRAEIHEGPKLSLKEAKREEDGAKNFKPKNKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQZ3</accession>
    <name>A0A4Q9LQZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1482p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001482">
        <property type="protein sequence ID" value="TBU10908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1482p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="62" mass="6912" checksum="4A35AB473E8BFBC7" modified="2019-07-31" version="1">MGVRCEEVLVIIVCKRVLGVSNMCSKLEGVSSNSYSPIKGVNNILLDKRNARNTRVKRVLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR46</accession>
    <name>A0A4Q9LR46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CHY zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0970p0030</name>
        <name evidence="8" type="ORF">CWI38_2096p0010</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002096">
        <property type="protein sequence ID" value="TBU09890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000970">
        <property type="protein sequence ID" value="TBU11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR46"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0970p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2096p0010"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU09890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="247" mass="29187" checksum="3205DBCBC72E0DCA" modified="2019-07-31" version="1">MYQEEPFGCTHYKRNCLIVADCCKRTYPCRFCHDDNEDHSINRYKIREMLCLYCGLIQEVSNQCCKCNKKMAEYFCAQCKFWSNSTEEIFHCAKCKMCRIGPQNRTFHCTDCNACMNKDLYNNHIHIENTLKSNCPICAEYMFTSIKNLTLLNCGHSIHTECLEYYIKGSHQCPICLKSIGDMNLYNQKIDFILSNNLKLYKDTDIWMCEISCFDCKETSKSFYRFLFNKCQICKSYNTRTGDVYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF8</accession>
    <name>A0A4Q9LRF8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1392p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001392">
        <property type="protein sequence ID" value="TBU11088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1392p0010"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="36790" checksum="6C90A869068461FE" modified="2019-07-31" version="1" fragment="single">TVNNYLEEFKLSEKTEFIPISQYDGSVNSLLRICKKIKSKNILVTKGDIITNIDVSSILEEYFYGRCKIMTVLIRTNTGHKLMGYSGNNLVYYTVNSMDILNEKKFEMFQKFPNITFSTEMDTSQVYVLDKSLLEYEESFFSFKASFLPFLIENLREKCPVKVMRVDSGYYFQINSIEAFIKASLAKKQSSFIPQWILNGEGEIFEYKNCCRQTLKKISFKDQNEDVRNIVGKKFLPGDFYLYNSIIGNNCRIGKGTRILSSIILDNTKIGENCLIQDSIIGESVVICDRCFLKTCKIMPKYVFSEAIKASSEIFSLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK0</accession>
    <name>A0A4Q9LRK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1596p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001596">
        <property type="protein sequence ID" value="TBU10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1596p0010"/>
    <dbReference type="OrthoDB" id="2195427at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29135" checksum="16F5DE364353B88B" modified="2019-07-31" version="1">MLIFLFIPGFLFIKFRLKRLNHPEYIGVYEKTPGLVKKKDALHFHLEKQGTHKVGLCSSAGCLTEKNSAAIFGPNGTAVLMVRNDDGTVTFMLNDKCLAADRTGLAFLKCGEYDKFEKITDKLLRIKGNNHTKSDELHDRKIEKEHISNPSETNHHHHHHHSNMSENPELIERTEKEHLKHLSKHKSDPNYTTDQDTARNHNSHVHLVGETSNRAFYTFYSYHPSDRHSTWAFHAYHHGIPLRWADEKTRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM4</accession>
    <name>A0A4Q9LRM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1482p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001482">
        <property type="protein sequence ID" value="TBU10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1482p0010"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="560" mass="66462" checksum="8665E9AA19B60B32" modified="2019-07-31" version="1" fragment="single">FILLFKICHKYLMIKKISLMIKSKWFYYVSMISLSILVFTYILNITHTYTFVKHNNEILTKKKSDLFIERNSNAFFYFVQVTDLHINTHVKTKGFCHFKECVEEINSINPEFVIISGDIVDSMNEKYDGIVSKQDFSQYLDLVSGINVPVYDIRGNHDVFGLNFDENMEYLNKFMIRKERNYFFEFEKSDNKFFFVFIDGTPKFTSKRFLNFFGYFDDKEFEEEVTNKIRNNNYDHVILTTHYPSNTITTTSQSFFNPSVYLCGHLHNLIFFNEMYKIHENGCTEAELSDLKNNKTYRILTFDNGIFNFSDVKVGKEPKIAILTPKDKKLKTKIEPNLTSKYLRFLVFNHQEVKAFFNDEKLELEKENNLFTAILPSNIGKIKIIASNSYGNSFKEIDIDSSNHSTYSSFPLNINFLIISIFFLFSYFFVLVFLTLKKKNLECIIRCLFYFLLPCALGKFTKNTWSILYNFYVYPNHYFFDTVLYFTTILFLQEIPYMLYLLGYFSVLPYLIVCIFHSKIMLYFHFGIVFSIFDLFSLPVFYKYFKSKIFKKSVITTNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP1</accession>
    <name>A0A4Q9LRP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1321p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001321">
        <property type="protein sequence ID" value="TBU11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1321p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="31711" checksum="9644B1BC874EFF99" modified="2019-07-31" version="1">MYSIFKKLLQTQTLDPPSILVILNTIDICFKSIELEDSNSSFSDILNYKIIATKVQEYASLKHKIDVFSFLLNEENYFKVENSNYKNLNSIQEASKKPEENEFYAVNETVELNINERKLSKYYKLIGLICLLYLIKFPERASILSSIESKKLTIFLENILFNPNCSDANIENIDLETNKTEITLLQAEIFDLKNQVSVLQAELEKTKKEYFDNVFCLSNNTNCDNGVLLKLQDEITELKERLEVENSVILNAWNILAEEAFNSEDCFIDKSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ4</accession>
    <name>A0A4Q9LRQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1828p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001828">
        <property type="protein sequence ID" value="TBU10351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1828p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15689" checksum="4D7286EECC21B649" modified="2019-07-31" version="1" fragment="single">SRELRNNTKDLNNLQSKKIRTAKLPSNIKTSPHKEKQASSFDSCFQYPTSSSKSVACFHNNPREINVFKIPNMLNQMNDKPKSNLIATNDYIGGNEIIVEIEESKLVVCIWVLRLVEGTSARKIMLIPISGRTKEILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU1</accession>
    <name>A0A4Q9LRU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1797p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001797">
        <property type="protein sequence ID" value="TBU10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRU1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1797p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="452" mass="53699" checksum="3B302DC4196EE10F" modified="2019-07-31" version="1" fragment="single">HLNDKCEFIEYINSYVSKYYFEEIQDDEDFFENIQENEKKIILNDFKEISMAYSKESTSNRNPDSSGFFQKIFRSLYSKWNKNKISENKVRNDIRQHTIFSKKPIYIDHEHVRKDMIAKAKNCHVTYGFHSDLSILFELIFEKYFHSSFDKEFYREHFNPEILKIYKVLSENPDENIREIAFENFYKIIFTYYEKHIKNLLSHVRSESFYKYENINAFFLDLSCHIRLENPTPCGSSFISLNSNPIKSLCNSEYVFVFDIDDTLFPTHKISSGFNKISGLFNTIPDRPLKDFLIKKEKFWTRKTEEVCEKIVEEFLQMNEFSELSTTLSHLKFKKELKETLQGIQHRKICFTNANNVWAYYVLKELDLLDCFDVIIHRESENSVTSVCKPNEKAYKFVEKFLGISTSNIYFFDDNSANIEAASKRGWKAFQVTESLVDVIKESLESLEKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX2</accession>
    <name>A0A4Q9LRX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1278p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001278">
        <property type="protein sequence ID" value="TBU11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1278p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="84" mass="9751" checksum="10FADE6FD2B9DC49" modified="2019-07-31" version="1">MKEDKSDKEECHKDSFVKYGGDKLFENLYESVKIISKNAEMPIKRSNYRRRSLSNTGDKVLSIKVANRSEKGLNSYMRLSMTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY3</accession>
    <name>A0A4Q9LRY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative subunit Rpb4 of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1453p0020</name>
        <name evidence="5" type="ORF">CWI38_1757p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001453">
        <property type="protein sequence ID" value="TBT99133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001757">
        <property type="protein sequence ID" value="TBU10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1453p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1757p0020"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="109" mass="13149" checksum="4D13615A4B68FA4B" modified="2019-07-31" version="1">MKIIKSVVKFLTRSDVYIFLNQSVPTKDQTTETLRYNVLEYCSDTLPKDRIEYIVEQLKNKNLMEIEIYMLIDQPPKSLLDLQLIIEEMEERYSEEELHQILMLFRMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY7</accession>
    <name>A0A4Q9LRY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1428p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001428">
        <property type="protein sequence ID" value="TBU11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1428p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020723446" evidence="1">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="310" mass="37063" checksum="DCA0D5C12F2A051D" modified="2019-07-31" version="1">MFLKLFLILVLGYHKSIIQATSDREELLSKDEIENDNVAIEEYLWNQLTDFSRNCLKKVIEKRHIKSKNFLLSMQTSFDKFNGQKRFFDASLENNFCLFCISKSNSFFVAFNDYLNEYDQISLYHAVNLAPKNVENFECLNLHIFLTKKVDFFNYFGQGFDIKSLELFFSKFSIFYFDKMKLKIEYQIEIFTKQIPDENICLLERDLLKVSEINNHENINKKTFNVHLFFNLGFSFSTEIFDTKNEKNVYKKIKFNIYIGLNNTIEYAFTLNLNKNDEMIEFIQNSYSFKELTDIKTKLNEIAREYEKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA6</accession>
    <name>A0A4Q9LSA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1445p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001445">
        <property type="protein sequence ID" value="TBU10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1445p0020"/>
    <dbReference type="OrthoDB" id="2188405at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19865" checksum="84EEB99192FF2687" modified="2019-07-31" version="1">MNLKGETDEQTELEKKISEIIEVNYSDKLKPEHKPLLDKIKLQLVPLQNKNILLIKIPDPVLCALRKFFTKFITKMRKIFSAYMIFVVRRADSYLTAKKKPNKELMEDLISNLCYPSVIKMRTTDVNLEGRLENAILERRSDFTEDDLEGMSAAFETLTEKKIRYTIGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH5</accession>
    <name>A0A4Q9LSH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1618p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001618">
        <property type="protein sequence ID" value="TBU10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1618p0010"/>
    <dbReference type="OrthoDB" id="2194544at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="508"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="757" mass="89449" checksum="F502CF32871996E4" modified="2019-07-31" version="1" fragment="single">MNKTNKDNFSKNNSLFYNNRGMVSRKTISLLETYFKLSCLPENYGILNSKPQRNNNDQINMVEFDLKIEGTEITMKEKIRKIKNIKKELSMEWIEHFEYMSETNGWGDKQMGLIAYKLIDDEDYKESLTKTSYLKLKKEILEIAYPLEMKRKLVSSLDEIKQTEHTLIKEYYGSIIKTLKPYSFMMNFSKNEYERKLEETFIKGLGENTELELIKQRLQNKSLKEVLNYLETVETGLLCQLNRRETSTNTIESTSPKTEINYKAGKWCTHHKSRTHNTKECNLLKNYNKKEEPSLKNLVLKQYSESDMNIELPTMINGRKTNVMIDSGSNRNYVNHSLIKEYDLKTEECKPIRTIFGSGSSQISDKKAIIDLVLNEKNSYKTEFYVLQDSPIKILLGNEFLINNKAVLDFKDKRLTICGVKYHLIGSERDTEELMDERLIDNICATTNDEELINILKRYNSNNNNFKSILNIKASLNFNSIPVQSKQVKYSVPFKYREAGMIEINRLLKEDIIEKSNSDFVSPAFFIEKKNKELRLVVDYKKMNKYINDDTWFIPNVEESIMNMGENNYFSRIDLRNGFNQIVLEEESKKFTSFFIMGRQWQYKRIPFGIKPGPKMFQRIISNMLENIKNCFIYIDDIIIYAKTRQEHVSIILEVLKILYKNNVKINFDKSEFFKNEMEILGFVVNNQGIHPKQSYFENKIFYKDIKTKRDVQKLLGVLNWYRKFIPNLSRRIIKLTDLLKKDKTRFSLNEELRNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS4</accession>
    <name>A0A4Q9LSS4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1119p0030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001119">
        <property type="protein sequence ID" value="TBU11609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1119p0030"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="278"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="368"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="643"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="511"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="712"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="959"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="750"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="807"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1009"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1079"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU11609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1127" mass="124944" checksum="76389687BA55D610" modified="2019-07-31" version="1">MQHNTPTTPLSLKKPSPLDIKLSKSLSHHLNTTYYTKPPHLQHTHEKVLSLLHILTLKYTKHIATQKNLPPRNYTSLIYTFGSYRLGVNSQYSDIDTLVLFPRFITRTDFFTTFVDYLRCNGNISSGGNSSEGNSSEGNISNELDSSKGKDYISSSNTNKEINTNINTHNTNTNINTNKDLNKEINKDLNKEINKEINKEINIEINKDLNKEINKEINIDLNKEINKDLNIDLNKEINNTNNNKDLNKDLNTNTNINKDKDNKDNNTNTNIPLNTNTHNTNTNTNPNNTPNILVIAVVEHAYVPLIKLRISNINIDLVFCRLNTMFIDKGLCLLNNNILKGMDEKCILSVNGSRVTDIILEGVNNKENFRVCLKGVKLWAKRKGLYGNVYGYMGGVSYAICVAKICLLYPNGNAFYLLKKFFKIFSEWKWPVPVIIREYEECGLNLKVWDPKSCPGDRFHKMPVITPAYPYMCSTHNVSSSTLGVIVEEMKKASNIIDEYVRGVSEVGGVSEIGGGDKGGGDSDKGGVSDKGGVSDRDMVGGDKGGGDSDRDMVGGDKGGVSEILGGDSDKSMAWGVSDRDSRLEGVNIGTCSVPGLNIGTNTLHPLNISNNTLRPVNTNNNKQHPLNKDEVTLWSKLFAPSDFFTRYRFYMTVICNSMDIEVWEGYVESKIRVLCQRMEVLEEFGGVIPYPKVFRVKWCNKVENVKDIEGVKGEGSEGGVKGEGSEGGVRDSRGKLEGVNKSIGKLEGVNNSSSKQQGLSNLSNKQQGLNNSSSKQQGLSNLSNKQQGLNNSSSKQQGLNSSTNKQQGLSNLSNKQQSLNNSTNNLHPLNNSNNKQQDLSNNLSNNLHPLSNSNNKLNKNFEKLFNKNICGLECSCRKDYPLFVSSVNEDVSVFFIGLQLNEFRVPGKRIFVDKQVKEFIEYLKENGKECGDGGVSVKVVKRSEVGVFMRAYTKDRGVSNSKGSEGGVSNRGRDVGGVNISRGIDEGVSNSTNEQQGISNRDMEQHPVITSSNKQKGLTTSTNKQKGVITSTNKQQGISNKDMEQHPVITSSNKQKGLTTSTNEQKGVSNRDMEQHPVITSTNKQKGLTTSTNEQHPVITSTNKQQGVNMLRNINKDLNENKRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH2</accession>
    <name>A0A4Q9LTH2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyhypusine hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0980p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000980">
        <property type="protein sequence ID" value="TBU11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0980p0010"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14903" checksum="86992831FD12BB33" modified="2019-07-31" version="1" fragment="single">LEFIYLKHSDIYLRYGAMFSLRNKKNISILVKGFKDNSALFRHEVAFVLGQLKMKESILYLKEVLDNENEHDMVRHECAEAIGAIGTDECHKILMKYLNCDADIVRESAEVALDICAYEMSTETEYCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL9</accession>
    <name>A0A4Q9LTL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1011p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001011">
        <property type="protein sequence ID" value="TBU11854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1011p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="989" mass="119237" checksum="AC8CFB64961F3067" modified="2019-07-31" version="1" fragment="single">MAPSNKLNKSNKSNKNVKKCWNDFKKSIYSHESTYQTLSGVFNTIIDYIYLINCLDQDIAKIEIIDDCIKIFIYFIKEQNLLTLETIESFIKVIYIFIEVFNENKETFFTQIVKILKNLKERFIELETMNVLLKLIDLENCEKIISDLQKYLKSFNTCHLNLNNIPSQLSINLIQENIQNIFEIINYSIFNTKEDFEILLILKILTNLRITNFKILYKFIKKIHIFKKDFSFSVMNIFVDYFSEIFISLKIESNFFKKCKNDFYYQLKIFKTFIPFIFRYRNTSSFKLLTKFIELFDSFSSQIKSDNVYFEIQDFFLYLDNRACLKKEKKQLYLLQETISLLFYGVFIYKTQISQQYCSKHNFYYENKFKDRFNSITESSNECIICFIFGSENLNCKENSKNIILKDKLSYFGFLEFLKIYGNLEFQNYLEKYEYFILSYNIIQLKNILDTNEFIKILYTDFKSEYKGLLVFIYFKIFPYKLKYLEMKDIEFLKRYIKNFVAYFSEKLTSLYLIINFYNLFDNKYEIESILSSVSFQKNINFLVLFIFIQIRFKSIDEKFIKNMYNLSEFLKENRLYFTKFIQQFNLPILFNYSYWGFYYDFQKYFRKSNFFSLIENVLLIYENNSSSFNNSSDVSNKKNISSIDNSDLKSDIHSFTFNENTQKPSPCFVLFNEDTEELKKLLNFILFQNYTVNIYLNINSQIKFTNLFKAPKTNVSFITETKKTFILEANEDLKKFLDFKIDSFEFKDKDIIVLKNFILLNLSHFNYNNLENLVKICLKICENKHDYSVDEYDSSISILKNIVSNFEETYFSEEMNSKEFNEKRNLISDILLYLRIKKIYKIRKDYQPKKILFKDPILTNYNKTNLSSEIENNIKPENLSNELLNTSFNFESDFSNDTHIFEILEKIIENITHLGDISSFKKLFQFINLFPNQNFIAEIMLLLFEQNHCNIFTLIYSAELYIYNLNIIPFEKNTKLSLYYSKRYEYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS2</accession>
    <name>A0A4Q9LTS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0930p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000930">
        <property type="protein sequence ID" value="TBU12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0930p0010"/>
    <dbReference type="OrthoDB" id="2191125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="15172" checksum="05ABD2FAE4A2B2A3" modified="2019-07-31" version="1" fragment="single">KKLTDNFISDFYEYVSCVEEYTEINNLYKRFISKSKCRIQGTFFKDLGCVVDKLKNRISVQMCDGEVYVKQNSVSRFGDFQCKNSAKMFDLSVNNTESDTLEIRHEDYRDEEYVREEKKYENIFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW0</accession>
    <name>A0A4Q9LTW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative subunit A of transcription initiation factor TFIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2228p0010</name>
        <name evidence="5" type="ORF">CWI38_1082p0020</name>
        <name evidence="4" type="ORF">CWI38_1332p0020</name>
        <name evidence="3" type="ORF">CWI38_1364p0030</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002228">
        <property type="protein sequence ID" value="TBT97498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001364">
        <property type="protein sequence ID" value="TBU11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001332">
        <property type="protein sequence ID" value="TBU11191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001082">
        <property type="protein sequence ID" value="TBU11685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2228p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1082p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1332p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1364p0030"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="105" mass="12301" checksum="B46B08CE862BB392" modified="2019-07-31" version="1">MDNDSHFLPKQKILSLNSLIKVNNKVDQDVLNNLQQFSEKFVSDILNRTYLVTKHRQSDVITSNDIMFVVEKEFDYSFGQRTHFPYNSVPSTEHTDRIAEVSKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD9</accession>
    <name>A0A4Q9LUD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1332p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001332">
        <property type="protein sequence ID" value="TBU11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1332p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020885164" evidence="1">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="49413" checksum="C25579B91EE41991" modified="2019-07-31" version="1">MFKKILLNIVLIGINIIKSASLEQKPTIETDVNCYFELLCRIENFGSKAFKKYISIVGTNVRNDCGIFIFDRDAEILELTRFFLDMFPTDKKYMFQTNIFLKNLGKEEIPLGEIAKEAKLVYTATVNEFKSSTYTLSSSKIQDTFEYVEKVEILRHLIEKNTKLQNFDIVDNFCFNRTFSPSLYPCKGKEDSITIILLGLAFLLPHELDVFEFIFEELYRTYNLYGKNIYFTFFPNIKSRHMNVFGRYLTSSDICRYYIFNFYVENINILNDYKTSKGIKILNSKKYGLYLTGETFTSENGKELTKKFENLDFDKDLLKHIDVAKIKISKTNLTTLVKLFNNKSINIVSTTQKLESGLYYVFLLNLCDIDDQKKNISVILHTNLLGTNMKIDKCESSEQITSTGDLLKAIERKFENVLIWATINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF8</accession>
    <name>A0A4Q9LUF8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1008p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001008">
        <property type="protein sequence ID" value="TBU11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1008p0010"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="64576" checksum="2470A8F75FCE412C" modified="2019-07-31" version="1" fragment="single">ETQNLELKEEINEMKKYLEKGNLNECSSSIESKEESENIFIAQAFLQNEKQSLSFEVEKVKKEINFLLESVISLETELGRQPHFRDFELTVTENIFLTRDLYLENNFSFKEIKIYDCKNLLERKEIIKMKENYSNKSNINNKEINTFEMIKNINENNKETPVYTFPIKPSLSTIRFLKDRIEILKDEKTRREKNKYFLIKEIQKYLYILNCKPEEINNEGKNTANKESDISLYNNENNSEQNNTFEKTSDTNIYNSGKNFTSEKYSTDKSSDKNICNSDKNNILENDISASNFIPLNDLCFDKNDLFSKNISFLEKLKYILEIEIENRKILINKITEEIEHIHDNLEGVSYKKKEIFNLECININYIMQISEYLDFLKNEQSRLFNLVFDKINNELIEVWNIFGIKERKIDRTIEGLEFMKKELKNLNTKKESFVKVLDLINKRKNFVEKMVTFEKVASDPKRLFKSSFQLLNEEKFRKSAVPNLLKIEEELKRELEAFESKYGIYVYNGKNYKNSLEQEITDRIINKSVFINNKCDTPRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS5</accession>
    <name>A0A4Q9LUS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0767p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000767">
        <property type="protein sequence ID" value="TBU12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0767p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="52500" checksum="8B1FFA548C0ACAE2" modified="2019-07-31" version="1">MNIQISMVIYTLFYSFFELIIGGASSKLVTKQKEEIIFPFKEKISFFENYIYKTLDKIHPGYSDNKFSNFYCIELVNNTEEVGFQNFFDVLAGTTSEHMYIGHFIIDWPSDKSISYTKIIKNCMKMLNNLIDLTMKKNNLKGNVESSKFTVYDNSENPYKYIYASVDNSDWNPDKSKILGNILNKSLSLASESSKKKRKAITFVTKELFSKLDILWFSKKIFEIIKSIDTNLTSPIFYLDRNINEQVNDIKFKRTINMSLTKTLLRFSYHKIVQSKNLTYKKLSLQHENHFIYEELILKCEKLMYEPSSDVNLAIFEPQSIIHFESMHPRLYNSNNSSPVEKDIFLNIIGLFYLEYNFKGIYFDKIKNTCGLDLKQNLFVISMEFAGQIKEFKPFNYFFIIDTTGKIVQSFRDDIGCIHLLENFSDVFTETDAKIANRFNELEFNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV51</accession>
    <name>A0A4Q9LV51_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0710p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000710">
        <property type="protein sequence ID" value="TBU12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0710p0030"/>
    <dbReference type="OrthoDB" id="6744471at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="28051" checksum="15AC09EE7BD2DD08" modified="2019-07-31" version="1">MLGYNYTRQQNEVVRYLHLLLLNRYKFKSSKRIRSHSVQEILDNGYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVVKISFDRLRRLRCFKRDKIDEEPTPSKIMLKNQRQKIKPHYYKSRNQIRGTDDKLNEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA1</accession>
    <name>A0A4Q9LVA1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0690p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000690">
        <property type="protein sequence ID" value="TBU12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0690p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="84293" checksum="9EC926EF77E6B12A" modified="2019-07-31" version="1">MSLELVASYKYTFNYKINENTEILFFCEQNHEISFKEEIYEDYKLNFIYNTDSKPPKNERYCFAYRKNNYINFEVLDELLSSKQFENIYENRIIQSDFDLSYFLKFTNDITEIPERLNSYQFKCISTTLQYLKAKENNNLIRFFQILLIKMDLNSTKNFKFQEIFDSGFFNIINCYIKFNLILAFLSNYMIKYFCIAGNIVLLDSDRESFDTSLFNEYIPYKNLLLNNHQVFCRLENILKDQNCFNTFQILLNEINVKSLIINSNYLMRSLYLGSRFSILSTDNWKAITIANFICSFSSFLSRLNLAIKKDIEFLTLKNVSTHRTTLISILKKYEIKGLVLIHVGVFENFDYVEDYIKFNKKIEYINFGNVGTYFKWWQSILVSTNIQRIILSFSSFVAQKNFIKEFCKEKSYTHIKYLELMFCHRKLLAKFFDSLSAFKSLQTLKISGFETDENTEPLFLKAIESMNNLEHLTIQQHYICANSYNLLFRDRKLKTLHLENLSLGIGILQIFFFNNYTSLTKLVLKYMNLSQVGLTDIFKLENLSDIRLECCSFHLTTEYNGLNFMSRKIRVLNLLGSHIKAIGGIKIFESVDSLEILDLSKSGLMPGDLEDSSMKWNSSLKSLSLKQGVLDIKNLNRIEKFEVLERLNLSKCVFVRCFFREISNYCRFFNSLNNLYLRDVDIELEDLRYLKKFMKLKKLSCRLSSLYLSTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP2</accession>
    <name>A0A4Q9LVP2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CWI38_0674p0020</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000674">
        <property type="protein sequence ID" value="TBU12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0674p0020"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="20">
        <location>
            <begin position="194"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="21">
        <location>
            <begin position="714"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="21">
        <location>
            <begin position="799"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="22">
        <location>
            <begin position="1002"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="22">
        <location>
            <begin position="1056"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TBU12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1155" mass="135021" checksum="4844263C5F1D92BA" modified="2019-07-31" version="1">MKRINNISWESSPPSESNTKKIVNKVITSILKIPEKNEKAEMRTNFWFNEAKKVKFLTNIFDLNNTKTHSTENNSCSKHILHIPRSASSTQQLENGLDTTHQSFSGRSISESVSSTLQMKNCFDTTHQSFSGRNISESTDITDKIQMQEETDYDLFDINSDLFSDDKKEYFKIQIKKIVRTKETVKLFGEKILFVISGDWIDLDFKINMKIIVFECYCCKNIENIKYSKKKINSQTSFSTPNEFSNKEISIKDVQKIVYINNNNYYLIVEDEILSVTKFCLAIKCIYAPIFSYNVSDISFNYSHPAMVIGVILHGTMEECMSKNNFTMKFILDYSRKSIKENVLNIYLCNSDEKKILNEIVKNIKLILKLGNRNLKVIEVEKKLVSLNFFLKGNVDCIIKNDNHIIPVELKTGKYKDLTHRVQAILYHLMMNEKYYKTQNHSFLYYLCDNELKRIEANHEEIQNIIMIRNKVAILNYNKIMDFNLHKEISLENNYLDFENNIFLNKIEMKETSNDSKNIDERLISNSPFVIEGIFKADCKCNDTEYCKIVEKFYNKSDLRSQFLQMMWESINQEEVYQKKQLYYETTYISQKNEVVVLKFKENYELNIYKSDFVEISTSFETKLCNGTIIEINDTHLVLRVKENIDLDSYKQLNVSLGKNHFFYKFLRFSLLKYATEIKDILCFNNSIIENMHANEEIKEKFMIPECFKKEFNNLNHQQKMAIHLALNCDNFHLIHGMPGTGKSSIIAMLIEILCHYKKKVLLVCYTNLALQNVILKLKSVSIYRSKKESLNNFKSVNEIKEYFDKINLVASTCYGFTDPIFVERTFDYCIIDEASQQHLLLTLIPIYMSKRFILVGDHLQLTPLIYKSKELGISLFEYFISNGYERIIQKIKSRIEVKNKPKNISYENSDCSSLENFDFLTSDNSDFQTNISERKELNKIEFDNGNSSLKNIKKNDFKNNSIVNNYMCVKNSNKIDFNQMEFSNSSKLFSSENNSFDENFQNKNVTELTVQYRMCQNIMKISNSLFYSNKMSMGGNHTGYSKFIDSTNLDSIKYFKSIKNCVVLCYFNTKVHELRKLVDKSVIVETVDRFQGSESPSVIVVFDPIVDCEVMNSRQRLNVALTRAKTELILLGNRLLMEKIPVIKKLLDELQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW6</accession>
    <name>A0A4Q9LVW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1029p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001029">
        <property type="protein sequence ID" value="TBU11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1029p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020320514" evidence="1">
        <location>
            <begin position="19"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="491" mass="58431" checksum="7070154AECA37F4B" modified="2019-07-31" version="1" fragment="single">MFFSKNILFMILINLKNSLFYTPFSDEINSVSFFTTNATHRQNDKTTDNIKNKEIVLKHLNALNINLLNIHFPVKIPMVLQQQNISDVEDGLIRFIESVFESTDIFSFAQNMKANKNILWFILEIRNKYFRFQIERNLSILVEKLYQINFETQTDPKPTNINSVLKYLKKFVLKKLFLKNKNFKAINEQKMKNEALLNESLKIFGQILTEFEFLILNFHFEGSFERIFLYLNIETSEIRKSCLCETGTNWVTGFFNNKSIFNILNEGGKRIHGASIGSIGIHLSNDEYENRYFTFCFQLNMYFDFVRREERMKVFETHFWDLFILKKSVFQDFSEQEITIFIIFFYQEKVSNIKLTDIYLQNDSLYFEIELDKTIKCKRILKEFSDKIFSISNDYHKFNLIFIDISFFRNSCVFDVKENFDVSWGQQKNDLSSIFSLKALKFNINLIFLRLLKLQIYNCQSANLRFKIILVEENILDKPALADVLREVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ9</accession>
    <name>A0A4Q9LVZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0588p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000588">
        <property type="protein sequence ID" value="TBU12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0588p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="52460" checksum="25672915AC11F2BD" modified="2019-07-31" version="1">MNIQISMVIYILFYSFFGFIIGGASSKLVTKQKEEIIFPFKEKISFFENYIYKTLDKIHPGYSDNKFSNFYCIELVNNTEEVGFQNFFDVLAGTTSEHMYIGHFIIDWPSDKSISYTKIIKNCMKMLNNLIDLTMKKNNLKGNVESSKFTVYDNSENPYKYIYASVDNSDWNPDKSKILGNILNKSLSLASESSKKKRKAITFVTKELFSKLDILWFSKKIFEIIKSIDTNLTSPIFYLDRNINEQVNDIKFKRTINMSLTKTLLRFSYHKIVQSKNLTYKKLSLQHENHFIYEELILKCEKLMYEPSSDVNLAIFEPQSIIHFESMHPRLYNSNNSSPVEKDIFLNIIGLFYLEYNFKGIYFDKIKNTCGLDLKQNLFVISMEFAGQIKEFKPFNYFFIIDTTGKIVQSFRDDIGCIHLLENFSDVFTETDAKIANRFNELEFNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW29</accession>
    <name>A0A4Q9LW29_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0996p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000996">
        <property type="protein sequence ID" value="TBU11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW29"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0996p0030"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14221" checksum="BFDCA93DBD8C2111" modified="2019-07-31" version="1" fragment="single">MENIGIDIGTFKTVISSSHEKGRIIYDELSKRSFPTAIQLTSPKRRFGNLVIQSRIKINKLFTTDLTDQHNLTHTNMFLQYCRRLIAHTTPTTNITLSIPYTFTDIHKRTILSLFSHPTSTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW40</accession>
    <name>A0A4Q9LW40_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0119p0020</name>
        <name evidence="11" type="ORF">CWI38_0604p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000119">
        <property type="protein sequence ID" value="TBU04558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000604">
        <property type="protein sequence ID" value="TBU12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW40"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0119p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0604p0030"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU04558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="392" mass="46180" checksum="AE44B0C4D707D123" modified="2019-07-31" version="1">MDRSTETELFLVTSISYTSMLAYKCMNIQNSLALELIFWILPQYIAICYPDWIVYLYIMLICIIFLKRKNLFVKYKEEPIKNYYPILDSYRAYLMLMVVISIFAVDFNFYPERFKKSSFFGLTLMDVGIGSFLFNSGAMSVKMSRIKLIFNSLIMIGLGFVRLFTILYFNYTVDITEYGYHMNFYFILGAVYLIYGIIRSKYNFKIALLLTVIYEYFLRVKNQDVFIFSEYRNSLFLKNKEGIYSILPSLTIFMFSSEFGNIGFSKDSNKEKYMKILGMSCMFLFIYYISNGYMIASRRLGNLTYVSWIVGLHSLHLFLSLTVTAFVSFKPLRLHVWVSKNMLTLFLFSNILVLIGNLLFDWKKINEMLGNIVNISYIFISIIIPYIFTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW46</accession>
    <name>A0A4Q9LW46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Golgi phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0601p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000601">
        <property type="protein sequence ID" value="TBU12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW46"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0601p0020"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="28839" checksum="CD7223AF2C14BF29" modified="2019-07-31" version="1">MDDEQISITRRRNIVTESEKEENEFYLYEEFYILSYLRSSIPTICDPVCICLRICILADLTFNSYITIDNKGNIKYLEGIITDPILKEVHNLIKENVYTPKEWIYSLNGESFSYSKIGLHIKNLRFRITKKMEENRIFISKKRNNIFSKRKYSIENNIKRKLCDRVIEYLTVRNTYSLRIEILIGCLSFCSVCGPILNSLPPKICLQAKTYVNEIRKKFKETNLCKNPIEIIVYQLMKTIYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW83</accession>
    <name>A0A4Q9LW83_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Pyruvate kinase</fullName>
            <ecNumber evidence="4 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0590p0030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 14"/>
    <dbReference type="EMBL" id="PITK01000590">
        <property type="protein sequence ID" value="TBU12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW83"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0590p0030"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="15">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="53630" checksum="A15C5576E2988128" modified="2019-07-31" version="1">MADNFFRITKIICTLGPKTSSIEAIRKLMENGMSVARLNFSHADHQFHKNTIENIKEIRNKLGHRYLSIGLDTKGPEIRLGNLSKSISVSKGDNLILTNDETIIDESKNILYFDLENLQSIKNNCEIMIDDGILKLKVIEVNEKSVKTVAMNSHKISSKKGINIPGVHLTMPSLTKKDIADIKFGLENEVDFIFASFINTEEDVIRIRKIIAEYSHKPLLFSKIETLIAISNIDAIIEKSDGIMIARGDLGAEIGLEKLFFIQQTITEKCKLTNKPFIIATQMLESMNIQALPTRAEVSDIGNSVLDGADCIMLSSETASGNFPFESVNIMSHISFETEKWLRKKSIENVEIPITNIYTALTINKMSRVPNVRTVVIFTDDIKEVLDIKSAFLSIPIIVASQDESMLRKISILRGCLPYHVLFNLKTGDSDFKHRLVDEVIYVIKNMYFLEEKTNIIVYYRVSQNETVFKMIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC7</accession>
    <name>A0A4Q9LWC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin-like vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0676p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000676">
        <property type="protein sequence ID" value="TBU12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0676p0020"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="37"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="557"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="643" mass="73220" checksum="F01CBD87BFE6A56A" modified="2019-07-31" version="1">MYFCNKEERNMHTTMDLLIEKINELQDICTENGISHTLDLPQIVVIGSQSSGKTSVLENIVGKDFLPRGSGIVTRRPLILQLIYTKEADEEYGVFNHCPTKIFRSFEAVRQEITDETNRHIKAKNDVSHVPITLKLYSSKVLTLTLVDLPGLVKVPTGDQPKNICLKIEEMCKRFISNKNAIILAVTAANVDISNSDALHLARTVDSCYERTIGVLTKVDLMDPGTDIVDVLAGRILTLKLGFVPVVNRGQNDIERKKSIRLALEDEKIFFESHSSYRRNKQYCGTLYLVTKLNNVLHEHIKACLPGLQEKINVLLYENQLELSRMGCVNLSPKESILRIINDLNKKFTDVLKGNCDISSTEIYGGARLNYTFHSHFSKFISSLNAMESLKDESIRTLLYNSTGSSSLLLFSHTAFEKLTKTSISVLKPHSLKLISVIFNELVKIIHAVCQSVVGRFPSLNDKIISCLIGLLKKNSEHTHNLVSSFIDWNMNYISTRHPDFIKWNEVLTKEIERTEMFSFKDDNQVFKSKDKRITFDSPPNILKINSAISEQEMMEINIIKSLVVSYFEIIKKIVVDQIPKAIMCELVYKSEEKMQEILFSEIYECKGIEDLVTESDETSEKRKRLEKNIKALKQAYDLMCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK6</accession>
    <name>A0A4Q9LWK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0525p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000525">
        <property type="protein sequence ID" value="TBU13118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0525p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="59626" checksum="979822442BA19F11" modified="2019-07-31" version="1">MIFPTKRHLQSDHECIVDNDSYSFTSDSKKSGILKQNTKSFLKGNRSLRTRFPKKISLNLDEKSNEYLSYLSDLNISQINLFLDFLSKDEILSPRNDYNQPKYNQIKISVLSKIQDEFNEVVHDIPDLKIESNNFRNDDIVYQKASSDSFFSKLKEKIDHVKNFGIKNKIDFTELYIFCQEIIEYEKYLFKKTKGKEILKRTKVLDINHSLCLIKKNSRFAVLSEVFFFFTLYPEKISNIIRQNNFIYVSFLLRIFALQIIKVLPKNQDDFESRYKFKNNLDNLIFYCEIFNLRKIFYNILLGFENFNRKAYFYQLLNILDFRQKLSLENYEVEEYLLFKSQLNTIFFLNLSPRFQIEDDVRYRKIIVLIGIVCYAKALNLNDLNIYLLRLTFSNLTNIFSILKNLSHVFLDKKHNIFYASLRESCERIYIVTRKEKIEKYSKAGESFPNPVSTEKYIWEFLLKLEQAIFKNYETNELNMEITDDLIEKVNTRISLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX59</accession>
    <name>A0A4Q9LX59_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0482p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000482">
        <property type="protein sequence ID" value="TBU13274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX59"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0482p0010"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="61" mass="7000" checksum="EC7DC9F1AEE7EE0D" modified="2019-07-31" version="1">MITQYILLRNDLKNFSKGALIAQACHASVSAIITYKNDLDNQLYISDLNNMTKVILKVFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB2</accession>
    <name>A0A4Q9LXB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0736p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000736">
        <property type="protein sequence ID" value="TBU12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0736p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16862" checksum="D976B35F132CD838" modified="2019-07-31" version="1">MCQNGKFDSNHNIFSFFYKILYLNYETQWKTLLSSIPNESYIGYGNILAYLDEYILSSAFQMNISNSSYFISIEDSDFPKMYLDEIVLVFDIDDTIFPTSFFRKKNPNFGSTRFYENSDLLQEELLKENPGRDNIGNEIYTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB9</accession>
    <name>A0A4Q9LXB9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0433p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000433">
        <property type="protein sequence ID" value="TBU13429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0433p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="424" mass="50284" checksum="6C001E3459588449" modified="2019-07-31" version="1">MDGIKNFGRKECHTGLFALYVLVGMMGVLLSYIGGMSNEKSVTVFMTKNSIFLICVFVSILFLTNLCFMVSMMCFLGNFVIFLILIIGPFPFWVLFLSQFRILHLIYLILPVYLFTSILLFYYRYCKYIGITRKYLRVSCIILMRNIFQLFIFFSLVFIIFGCVTVLLFYLICRYKDSLVKYIMFDSIIILFSIWSYFICSFLLSTLVSLYIYYKMSTCLADDGINPLYFTFRNIKNHLNDLFLLEFMNKVRDEDTDVSLVPIRHKLDVFVVWTFVGVICNCMECNINGMDSWPKYFMTFYFLCYFESKKHFKNVFKSINFKNIFMYNRPTLVLRTFQFIVFGLLLVCINSSFKMFYQMSIMERIFCLVFSFVFLDFIVVVEDSIWKCFVVAGCYDKELVDSCLKNSYKNILYVKEKYSEKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF3</accession>
    <name>A0A4Q9LXF3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS_1-like transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0779p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0040"/>
    <dbReference type="OrthoDB" id="2191737at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49516" checksum="2B21EAA62E4FE8DC" modified="2019-07-31" version="1">MKWYAFLVSHYICRMLLPMTSFIVPFLVEEKKFTNKDIFNKITPIFFISSLIASLIGTIIIEMIGNRNTLLIDTGLELLAYIIFVWMDERSFVFGYLVALLRGMSTSLTSVSKGVFLDIKPDETSGSKVIRNYNILKKTIGIVSCLIGQDVYFSCKNHRSNLYFSMAMLILALCFGFLIENNKKNDKKVKSLISEILNGGSFGKLVEIYNKDILFYSLMNIIGNVLYMCLAMYSANIFLERKKTVSEVGMMGKILYKILFPFRAISFSIVKILSFFDGSIFYQRSYEKNALIYGYIDALAKICGVIMSFLMTLIEIKGKYLVVHSLFLIVALIAAIYGLGYTQSLLHSYIIYIIGISLGTYMNIVSGSELAKDKEHLHIFYGTNLFISSVIHISISYITKWRNCSAEDKMFYYFKTCLTCFILNCTIGFLILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI8</accession>
    <name>A0A4Q9LXI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0309p0030</name>
        <name evidence="3" type="ORF">CWI38_0703p0030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000703">
        <property type="protein sequence ID" value="TBU12591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000309">
        <property type="protein sequence ID" value="TBU15685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0309p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0703p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU15685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="319" mass="36588" checksum="12BB07020377B4A0" modified="2019-07-31" version="1">MNINTKEILWTIMAKSRKNQNTKKYQKNSKKDNNESNMDESGYDNKVVSGVDSSYKTEYEKYCEHVLKEENDVTDNGALEIIEKQILKDKEVNNSSVLNSELNISNSATLDESELVSTESIKSNKRLIAISNRDVVNLINEHEEVTRIKTDKTKIMGQKPFLGLEEDLKNKIKETEIMNEEESRNIGNLLNNQAIKESIIKRSAILNTGCRVNITDFSKEGEIHVVELLKEKNDCGKPLFQAENALSYAKQTQEEKEKKKCTQKFSSFQNADMMQPHEFNNITEVKYVEEVKCPSRVRRVSKFKKLISRISQIFVCGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN6</accession>
    <name>A0A4Q9LXN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0392p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000392">
        <property type="protein sequence ID" value="TBU13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0392p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="542" mass="64274" checksum="91E6FBEFE57B2038" modified="2019-07-31" version="1">MSFPSFIDILNEYNYRLIFTIMNIFNFKHDKYFNRLIRILWGSVVFNPIAMEKWYSKTSTRNEYEYPSCISKIALVELLKLYRVRRETLEKIEDTSYLLNWTVSFKYDFMNATDEYLYIEPSIINEILKRSKKSKFFQELLDTFFSVHKFKNLFLYNISFKEEHACIFNLSFFTYNESLVLLFCSNLDILIQKTYQVFNSDCLNALNIIYSKFTIEDEISWLKTQNFKIINYVVDKWESIFQFCVNEPTSPGFDVLLNVVKEFFTKENNPNIFIHDKIVSCYDFCKTKDLQIYADQSKVEKYHNPGFPLQTYIFIQYSIVYLTLEFVIINFKALKNIYITFTDTDIKDFNIKDKEIIENIVDIQFDRSKVYFNFLSKILSFPFLENLKFFKSSIIFSNTKISLNENQNIQCLIFENSSVSHQNIFVELINKMIGLKALDISFSKKILNPFISISEGFHLHLDKLNYLKYHDSESSNYNLLNFSCFCCLSVFEFGSELSSNYPEGTLKEILHNKNFICVLMLNINGVSVGERDRSALEKCRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN7</accession>
    <name>A0A4Q9LXN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5098 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0517p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000517">
        <property type="protein sequence ID" value="TBU13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0517p0030"/>
    <dbReference type="OrthoDB" id="2193759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031505">
        <property type="entry name" value="DUF5098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17023">
        <property type="entry name" value="DUF5098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="58354" checksum="D5345A30D8D44CC7" modified="2019-07-31" version="1">MDQSSVLNGKINILYEKLNWLKHFFEHTSVYVQRSADLLFRATQIPRDSSWHDSYILDLVESTDQKRKLCDELYKILDITIIKDINKIIEDVKELQTSMYKDSECINKVISVHLDYVNDKKKNHLNAWLDMKCDPWTTERELKSAISKFITEKEKVQMEVKSKVCKYAGVFEKINEEYNDLFLNFFKIFMNHHVSVGEVFERFVCVKRKNFSETFYDFEESDTSKNSSESEELMHKECSRMFVVHKEALEGDCNFGAKNNLLFPYQENDRLTENIRLAFDAVIEEVSSEVYKTKQERISKDIKIRKYGIFRYKKGYGNEWKVANVILTENDFLHAADFETILDLNQTLKDKYANFIKILLNVDSRDFLGSNEQNETVCEKICQDILKSDCFEKASLKGFPLNIKIMNFRINKQKYEIYLEFKKLSSFADLFISRNIKLRPFILKDAYDLYFGLSNSLVKTVKNEEIKEERNNGNELADVALKLEEYTEENPWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW3</accession>
    <name>A0A4Q9LXW3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0371p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000371">
        <property type="protein sequence ID" value="TBU13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0371p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36476" checksum="B392628C919DDC9D" modified="2019-07-31" version="1" fragment="single">MSKKIERGAARRWSVTTVVCVVYRSISRKLNVKYTKSAMTGEAKEFLKVIGLEINKEKSATNDTCCEDTAILEDVSVYKYLGIIEDSRGIPTRSSFEELDDAMRAVLVKNKIHLCPRFKERFVELRGEHMLLQLLDCLEKSKEISTRRAAILKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYKARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDKNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKFSKRIRSHSVQEILDKEYAEIRVDTRIKTDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG3</accession>
    <name>A0A4Q9LYG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0625p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000625">
        <property type="protein sequence ID" value="TBU12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0625p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="818" mass="95584" checksum="89EA611C53ADB4C6" modified="2019-07-31" version="1">MLKYKVKIQLQRYCYLIHCIKFIFLEVIVCASSHDSGVITFGLIDRDWSCKYPEDVDYKTVKYWLVSTENGTSKLCTGDHCVKTIPIRESTAYQYVFSCTKNATFYNHEPLHSYEVIYLNRWNVKFRVLNNLLNNSKPEPFIFESYLKIYYQDFYVIDCYLNPRIDLNFHNLPYKLFYKILAVLTSLDPISSKYLNQVYSNLLKNGLMGFESKKILADPKNYKMKYLNSKKHIFMYFFSVLYDTIDACLIQQKSLVYIFKRTEDCIDQCFKDIDNIAFIRLKVTIYSLDVISLNFSSFMWSVFNWLLSLINISGLYIDESETVYYGIKLPVLYHSNANDVVKNIESNKSMLNCKFFESLCSATLQNISYLRFDNLRLSFYLLSSFLENNKISHFELSFCSFDVADTRTQLSKILEKISKLITLKLRGLLLWESDINFILSSIIRYLVLYDCTVVTGTEKAPNYTYRPAYKIFKTLTHLDISFSKLPINFVSALLRSDSLENINFSSFEFSKDDFVSLSLFNFTKKLNYLKIVNLTTNDQLFRFFEGIKSVHTLILSKISNLANLDFFLRLPNFSESVVTLNLSNNFLSVAILNLLGKFNQISCLHLENSLPLNSEELDEMPLFRTLEELDVSHNEFKAIGNNFISRCLKLRKINISNSKFHKGALMCIFTNNLVNNLLHLDLSGTELQHGDFQRVCECKLLKYLAIDFKKDLVSFPYELLMYASFKMYLNFLISAVEKIEILDFINLVIEFPNLKKFRILCETLYVASEKHHQLSLGSYNTKSFCYIEVLYVNPISDCIIEFLQSTSIFYSISFFNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ4</accession>
    <name>A0A4Q9LYJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0295p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000295">
        <property type="protein sequence ID" value="TBU16695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0295p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU16695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="11975" checksum="FBA0322A5D0B3CF1" modified="2019-07-31" version="1">MTPIKVGISSQDSLQIVETEKPRNYGLLSNELGLLRCSVEIIPYLLTWDGIVIKYKAYIQYIVLKRSSKKSPLIDEKDLNAPGTKSPVKQPEEPTININEESDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK0</accession>
    <name>A0A4Q9LYK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0451p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000451">
        <property type="protein sequence ID" value="TBU13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0451p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16969" checksum="E87CE968068B0BC0" modified="2019-07-31" version="1" fragment="single">DKTHFLIINDNFNVFFCEKVAVNSKSLNLFALLLNTLDIKYLHIPNPNEKNTNAFCFVLENLKKKIDEIIFYLGSIYDKTVETINRNLNFVDLKKIVFIKSKIITNSIFQDHLSKIAEIIFYENKVSRKEYEIIKIMDMNNINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY0</accession>
    <name>A0A4Q9LYY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0413p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000413">
        <property type="protein sequence ID" value="TBU13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0413p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="264" mass="29503" checksum="5A03D74DB930DAA9" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPVIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPIPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ15</accession>
    <name>A0A4Q9LZ15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0565p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000565">
        <property type="protein sequence ID" value="TBU12985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0565p0010"/>
    <dbReference type="OrthoDB" id="277458at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="222" mass="26258" checksum="00C492991FA62D3C" modified="2019-07-31" version="1">MLGVYFPISLFLLSYILYSSYSNHFLGLEKIENLTINKIDAKISECNIKIKSEKLLLIAEENSMWLSIERNKFITIENSGEYNKIFIFKLIIYIDKLLKINKKIIFLLEFLNKKSETMNIKNLISYLENNQIYNNEYLKETNQNIKSIIVSIKNLNLQLLNEFTEISKNVNTHDKKEYDKKHTKNSIYIAKMINKLSSILSFINCLTNYENNIVMNIYYMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ47</accession>
    <name>A0A4Q9LZ47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0243p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000243">
        <property type="protein sequence ID" value="TBU18378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0243p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11088" checksum="0B1F842EA62A1274" modified="2019-07-31" version="1" fragment="single">MGRRKKIDSENIKNEEIKAVNNTEISLKETKPLRYMLLQSACSIPHPLSFCTDSSACGPANTMENLNAPAIPEGNRLMVLPSILDSVTAVGQEWPRYAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC3</accession>
    <name>A0A4Q9LZC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0237p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000237">
        <property type="protein sequence ID" value="TBU18514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0237p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="25832" checksum="60B6D21C32F66526" modified="2019-07-31" version="1" fragment="single">VLILAQNNLDYEDVYNLSTFENLRKLDLSYSIRKPDLIYLFKNSCISKSLEFLDLSFCKLNANDILGILKCRNLLFLILKCCNLKYGCFSCYDELFLDLKIQLLFLCISHCNLPKNALDIAEFSTKYLNILHLNGNTISKKGFDFICNSLKLKELSVSMCRFRFRFLKSLLDKPIMETLEVFKANRNLCHSEDLINFISSANEIEYYFMKCRDESGQMVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN0</accession>
    <name>A0A4Q9LZN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0205p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000205">
        <property type="protein sequence ID" value="TBU19522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0205p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020758370" evidence="2">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="7151" checksum="CA8981C6A3569461" modified="2019-07-31" version="1">MKIFIASTIAFIGYVFGQTSSPKAATTEQSEQGLGTATNEPKAAMPAKANPPKRCPPGAKGCVPEKQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M048</accession>
    <name>A0A4Q9M048_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0257p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000257">
        <property type="protein sequence ID" value="TBU18006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M048"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0257p0020"/>
    <dbReference type="OrthoDB" id="10657662at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="562" mass="66329" checksum="062AA344F2DA6E06" modified="2019-07-31" version="1">MRKIKLKVYDKFNKSHILNTYKNMTVGETLNEAFPESDTLVIKMVTKEKKFRLDTEENGEFGKNIRNKKPMIFDSNDEELKKTFKKVSKNYKTKKTSSKYIYRFKIIERNTRIEEILKEIIFSGYKFRFYLVDTEEFIEIYVNTCVRYYSGGNRSYKIYCSENTTVDDIENEMAMVFNVEKVFGLFGYNHLGLFKLKKNEKVLVIKELYCIAESNFNFFQLQFKNVNDALLQMKPIYSARFYKLQTKNDILLFKCMKEYGLVENALFKIYDNGRKLVLQNIDQCKVFLEKYYGKFLLIIEDGLNELILCNYDEEICEQMYFSLLGCKNKSLIREIAGNEVKNVSFENSNYLETSDKFDLSFQNSNSFVKNVSQDISRDEFCKREATKVKEFQENKTNNENESISKILNEMNSFLESTYSTEGTLKSSKINSDITLNISQQNLDNDFVDKHTVTFQNNDLNEISSLIKLNPITKTETKRDKKKSYKRNKIKKVFQNINHKKTEKETSSTSISNKLENSIYFKNQPKNNVPRNFTENSSDYSFLLEETESSQNTEEFIHSYFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D1</accession>
    <name>A0A4Q9M0D1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0265p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000265">
        <property type="protein sequence ID" value="TBU17873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0265p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020854726" evidence="1">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="51666" checksum="41BE4689DCB1D693" modified="2019-07-31" version="1">MAKFLKFLFLIFVTAFCTKNPEKRKKYYVDTLIDIIKKEIHKNYIEKIQKYNKICSYEFLFLESNNYFNMESADEIYKFNFAKKPKESHILVGLVNKKEIDCGIVCRHSISLTNDDFFSFIFQDKYYQVRYKNIFPGNYSYHKTRDIREYSIKKHILRFIFWHLNIFKQTINKFISDRNSYSFVSIFSDMIFFENTDYDFISRLLLKQTYTREKNYYLLINDLKINDEYYESTTIKNILDYTFSNTIFDSIKNLSFERKDELNTIPNNNPNYNYHTKIVVKEVHICDCKRYYNLYEIYISSFQDEIIRNQETEAINIFGYSSVNVDIVTFIKSNKSKKVQKSIPEISYIIIRDRQLNMEYHIAFTYKNHNYELVDISVNQNIPGFADAISLKEKISCILGLVIKYRQYFFQLVGWKQTKLISFKRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H4</accession>
    <name>A0A4Q9M0H4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory subunit of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0227p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000227">
        <property type="protein sequence ID" value="TBU18864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0H4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0227p0030"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="99"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="359" mass="41652" checksum="BE4C9FA5631D0C1B" modified="2019-07-31" version="1">MTLTKRTNYSDAHIKIRIIKALGAIKPVGIHKHFYLVKILRNMKKPNIITADNIWTFLNTTFPVEKFDEEDFDRIFDNKMSFDKNFEPYKPFKMIDNNITVHPLVMASVVDHYRRCDSKRVAGIVMGKMDERLFVTKSYAVPFSEDDKGNWFFDTSYSDKMYALLNKVDSSEKILGWYHSGPSLHKNDLDITKSFMRDLPNPLLVIVDVKAFNISEQVQIFRLVDDKSGKKNDKKFKYISCVVEGEEAEEVGVEHLLKDIRDCSVSKYFTNVKDIKSSMEMYEKSLTVIVEYLQKVKNNEIRVDQKILRYLQKCLNEVPIVSEDDDESKMALFTSLLANAVVKITDLVLSRKESVSEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M7</accession>
    <name>A0A4Q9M0M7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0376p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000376">
        <property type="protein sequence ID" value="TBU13630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0376p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15549" checksum="637F4E9253305629" modified="2019-07-31" version="1">MTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIALKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P9</accession>
    <name>A0A4Q9M0P9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0114p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000114">
        <property type="protein sequence ID" value="TBU20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0114p0030"/>
    <dbReference type="OrthoDB" id="410404at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16520" checksum="03FFB458C557C7C1" modified="2019-07-31" version="1">MGTFFEYLGNKRENCKQGNIEILKNKNLKIPTSTPGKKKPYKTILKPIVMHARETLILKKSNEAILSTWNIKTDKEPELTVKISNNIELDDLYRNTGWITKIISTRPRCPSHLEQIPEVRTVKRVYLCNSEGRRLPVTAKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C0</accession>
    <name>A0A4Q9M1C0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spo11-like meiosis-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0071p0040</name>
        <name evidence="3" type="ORF">CWI38_0343p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000343">
        <property type="protein sequence ID" value="TBU13764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1C0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0343p0050"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="2">
        <location>
            <begin position="128"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="289" mass="34210" checksum="E63E725E53D6CBE4" modified="2019-07-31" version="1">MHEKIIEIIKEETKRLIDSKITKNFVQRLKFYEILFEMNTSSLSKNVREIFYISPNVFLNQNVIVTMANNFIKKYNLTYEDLLITASYKGLFCGPIEIYYSDYSTKMSGILIPELKNVIKITTSYKNVLIIEKESFFTFLIELNKKNDFIKNTILITGKGYPCVNTRKFLSFLCVNFYGIFDFDPYGLHIYSVYKYGSAINKDLKILTLKRIGISSTDVFKYKINENETIPLNCHDYKKIEYLYKINEPDMVVDLDFLKGYSRKMEIEIFCLREEYFIINYLKEKISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G4</accession>
    <name>A0A4Q9M1G4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CWI38_0302p0010</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000302">
        <property type="protein sequence ID" value="TBU15971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0302p0010"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="23">
        <location>
            <begin position="180"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1115"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU15971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1155" mass="132443" checksum="E0F5A32A3B91D8D0" modified="2019-07-31" version="1">MDDPYTPKKRPFKQKISPLRYKTPTTESWDGLDISNQGIKNISSYLFTLTFIKHLYINNNSLSSIPPSISLLKNLIVLDISRNYLRSLPNEIFLLNNLRELHASDNMISSIPLQIGSLYQLQRLNLNNNPLIEPYNTLYLESENSLLSFCRENNTVYPIPSPREWIEYESCCGLSITVGSYNILCPSYATSTFYKYVPSWILSWENRRDSILQQIIEYNVDILCIQEMDANSYNEYFNPSLCSSVVGGGVGGVGGGVSSSLEISKETNKEQYKEQYKETSKEHYNHYNKTYNSLFYPKSRYRSMDNKNKGNVDGCAIFYNKNLFSCLESKCVEFNTTVLSDKRFYEKGDILNRNVNKDNIGVITILEVKRGGNAGRGGGSRDSSRDSNRIDSSSNIKDNIRDTKDYANTNIRDTTNTKDYIKDTKDTYVVVANVHLCWDPEYTDVKLFQSILIIEELEILVQKYKNKGKVCIFLCGDFNSLKNTNVYKMICTGRIDNSSGVGYDSRVDSKIDNRIDSNNTTYNILNNQSNNISNTDTNNNNQPNITNTFNGFDYGPYNNGFTHNLLLSDTHENTLNDATCYTPGFKGVIDYIFYGGEVKVNGVLTGVDEEYFSKVVGLPSVHLPSDHVFIGGKYVIRDDLFLFIDYLKLLAEDGQTLEEMTEEVKVVVNNIGLAINKGKSASNDPCCEDTATLLEGIGVYKYLGIIEDSRGILKSKSFEEVQTKLIARVERLCRRGLNTRNLFQVINQLDDAVRVVLVKNKIHLRPGCKERLYLPRKELGRDLHSFEFKNEHMLLQLLDCLEKHKDTSTRKAEILKVENNNKTHLSLIKNFLKIKYGLAEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPCDEAVFCYIQNRNLFWGAEGMYVKKCLVMTINRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRIDTRIKTDVKIPCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITLNGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETTSFDRRIGHESGPNAQESWERASLSVILGAEMHKQPIPPLKQVDNEEDDEPTTNTNEELEEEEEIEVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P0</accession>
    <name>A0A4Q9M1P0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0041p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000041">
        <property type="protein sequence ID" value="TBU20640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0041p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="51640" checksum="D9095BB9CECF9C45" modified="2019-07-31" version="1">MNTMIFEFIKYFVEASENNCERLSTFTEQVYLKFVFDSKYNTTNLCLLDVFDRYKKMQFSVSCLFSSPFKPQISFSSIGCFTIKFLEKGLIFYKKEFLTEKDLPGKKIIWDYSSLKYILNYFRIYLKILDRFRNRHQKSFVSLIFSEYPHRILNNSISKKFIKFFSGNDETYLFVFKKADITLNFLLENLKNTAFKHTIGIYTLEIPRDSYRNLRDKLFIYFYKLCIYNKINIDYNFLKKIDKVLYRVINNHLGITPNESPNIIFSKNYIQYFKNLDNKPDEFFLEDYMYVQPRCLYSRKKYNHDTETDESFVIDAQRINKFYHEKISLTFLHFHLWFAEFTDRSKILRKFPEIKSLATMCKCSFGSYILQKNFLLDLGFNSRGECVFMYINNTDEKYSVLDGAIFYKKLEETMSRIKKIMYFSGDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W4</accession>
    <name>A0A4Q9M1W4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0249p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000249">
        <property type="protein sequence ID" value="TBU18227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1W4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0249p0030"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU18227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41690" checksum="BDE65CF110C85CE3" modified="2019-07-31" version="1">MNSDSCLLFDVPINKKIPNTNYTVDCFRMQPIDCTHYFLTHFHSDHYNGLTSSFTPKIYCSQTTANLLTKKIRIPVKNIVVLNLYEKYLLDNDDYVIPIDAHHCPGSICLVFDIKGNKILHTGDFRASKFFYEQDFLTFNFSLVFLDNTYESYRNFDPQEYLIKQIIEDIKIRLNPKGLLFPLKYKFVFPTYLIGKEKIFLSIAEYFDYGIYLNKNKNETIKCFCNSVKDKLNQEVRTIMQFCGKNVGTMNCFDRITTNICDNQIMVMSMTFLSQIKLNQLFKDVKADKIIIYCGTGWKDKTVFYTWKKSPGREIKKGIELKYFPYSEHSSNEELLNFKKLMKYKKILNTVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X8</accession>
    <name>A0A4Q9M1X8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0034p0050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1X8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0050"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="631"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="748" mass="84337" checksum="778AB3137012E029" modified="2019-07-31" version="1">MVEQNKIKRSKEYSEGEYDVGEYSEKCYDVGEYGEKENGGGLDKEKNIRGNKEKNTQYDVKEYNEGGKRLLKNSILSDEMPLDFKSKYIMSIRNTDDFFDLSATKYLTFDKKYDSVYNKDGWFVGGKINACYNCVDRHCLKYGDKKALVYVSNEGEILSYTYNSLKKEINKYCEYIMSVVDITKMDAITIYMPNMPETVFAMLGCARLGIPHNVVFGGFSVDSLAMRIEETKSKIVVTVMRGRRGKNSINYFENVKNAVKLVKNIKVERILIYDQCEDIVESCVGETKVDKFYDIDLAGDNVPCVSVDSTHPLFYLYTSGSTGKPKGIAHSTAGYLLGSALSVSDVFCFGRSDVFFCTADLGWAAAHSLTLYGPLLVGGCTVIFGGMPLFPDNFIMLKIIDECKVTHYSTAPTVVRMLQKVVKKEDLVGKNAYNMSRLKGIACMGEPLNKEAYAWFKNIFGSDKLPIIDTYWQTETGSVILAPENGVDCGPECVGVPFYGVEPFIAKKVEENENFNEFEIRDEKRIFSEIERQESEKQESKTLNQNLNEDKEIFVRAGVGEIGLLLLKGRFPSMAFTILNDHSRYLKYYTKYPGYYYTGDECYMDSKGYYHIVGRADDVINVSGHRLSTMQIESVVCSSEGVVEAAVVPMNDELTGQCIVAFVVKYDYSICEKVKECVKKTVRNTIGTLCNVRHVIICNELPKTRTGKIMRRVLKCLLNGECLGDITACGNLDSIEDIKMVIKNIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M205</accession>
    <name>A0A4Q9M205_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0030p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M205"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0030"/>
    <dbReference type="OrthoDB" id="2193863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="11878" checksum="5FA72B33F75A69B2" modified="2019-07-31" version="1">MSELQNHELYVYSALFLREREGVVTVESLKAIFEHLGLDFSHKLASQFIMPVEEYDRIISNVGSASSVCTTADNGAAKVEEKVEEEKNEEANIDGDVEVDFDDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M247</accession>
    <name>A0A4Q9M247_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small COPII vesicle coat GTPase Sar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0019p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M247"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M247"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0010"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF18">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="237"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="342"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="516" mass="58851" checksum="5F9382816ED0869A" modified="2019-07-31" version="1">MNLEWKNVEIEILHDENKIECVLSNANGKIKSGSLCAIMGHKNIGKSVLLNTLAGKLSPNFLIKVVNEKWYEKIGYVGKDICFYENLNQIKEDLQIKEISDLAVNVFDFDEKKQLKIATEFFNEPSRLFIDDPTHGLNSGSFNNLLKVLKCLCVKYKMTIIFTIQRPSDEVFNELDQLILLSNSHTVYSGESKKAEKFLQRMILEKTKQKLKDIYRSTIGYFIQSLFGTPVSILFLGIDNAGKTTLLNKLKNESTSTFVPTHHPMKNEIEIGNLRCNIIDLGGHKAARLAWNDYFYNCNGIVFIVDVSDTERFAIVREAYNTVRNMKIQRKSVKVPIAVLMNKIDLLQHTSESARNDMQFVDRLRNETGIEDMDDIDGQPVSVNYVSIKDESPTNLSGQLVHSFMWLEKMYCYCRGVITSSMIKGVLINRRVIKGCYYYLTGVNYYSMFKGVLVITILIKESNNNNFLEGEIDLSAAGAHRKQALLDEDMFMAEHLRSEGYSVVPPRDTKSGHVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B8</accession>
    <name>A0A4Q9M2B8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0018p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="78835" checksum="4EB34100EB713BD0" modified="2019-07-31" version="1">MEYLILEIEKAGKGILYLSKKLYKGYLSPFPTPNLVLVRGSFKCQARECIYIDLMKTNVKIDERQIIIQERDENLKFYIKNPERSAYLKNIIQYILFIKNTENLQSKIKYIRNFNSEKLLYFNFKSYDIYNQQYLYILTEDISRRVVSYKELDYKNRKIVYSDGKIEVVLDKKITSKYYVKYLDLYFNAFEKSRKIEKRRKFHIWNYFWDFKTLYEEIKQYITKNGRENIIKYVNSLVQKNIQPASRMTSNIIWHTSREISIFLNLYLGCIFQTNNKCWEIVPKNFLTKYIKNKRSCIGNIKDAMHLENSTFGVKKQDIIIYSIVDIHFKNSYLDEIVWIDKIFYNSLITSEIIEICDYFIENQETNIFYKNIFLIIKILFTENILNRYLNFKNHFTKMNKELPSTIFKAVLAFLIEKFDKITGKFKKNVKIQITCNTDIYILLGLYGLKYNIPKMRNEKTKKYFIQLIIHRGDYKMFNKVYFKYFSFNPEILFTKYRHEFKNMEKKRNLSLNSYIEYFMRIENLLYDILLDFNLQNKRIFLKLLKIHCEIRLYSKKRRSNFYNSLKNQNSKDLENNILMNHIMPEPINEQIQTKMTAIKLFNKRKMNVLILSRSMSIFKNYELSQKYSKIFNNLMNFMDDFIKLNTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I3</accession>
    <name>A0A4Q9M2I3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0211p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000211">
        <property type="protein sequence ID" value="TBU19448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0211p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="458" mass="54163" checksum="807500D28D268616" modified="2019-07-31" version="1" fragment="single">MNFFSTRYKKRLFEYTFLPNLIIFLYASCLLDSVSPYKYIYGFIKNEKLKIRFFTGNQETETYSVQNDVDFKLTLLNDESTLFDEKTSAFTYGKNNFISFEVLDNILSLELSDNPNGKIECNFNLYYSLKLTRDIFEIPDEVNYIDIKNILFSLKYLKAVKNKNMTLFLQALIVKVFLNHKKPTLKEHFTCMEGLLDLGFWCKIDLQIKEIFLSSFLNIYMVKYIFQAGNLIISENIEEFYYISIFDEHIPYKNIFINSGRLFLLLEKLLHDSFILKFFQILLEEINLKSLIVEGFIEYDIPDTKFSFLIFSLNTFKSIALYNFIRSSSSLFTEKVCVACRNDIEFLRLEFLNITMNVLQLFLEGKKLKGLVLKNVRMPENILPIDRYIQFPEILDYLVLENIEIDLILWKTLFLKLNVCTLILSFNSISTEKSFINEFYRFSKPKNVLCFEVSFCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J8</accession>
    <name>A0A4Q9M2J8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small subunit of DNA replication factor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0109p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000109">
        <property type="protein sequence ID" value="TBU20228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2J8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0109p0050"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="353" mass="40646" checksum="55D1CEC262B320C0" modified="2019-07-31" version="1">MIWSDKYRPDTFEELGEHSKVGTLLKCYTINSLPHLIIHGDCGHGKKTILYCLITHLYGKKPVPRLKEIQLETASGKVIDVSYVESDEYIEVSPSEYGYQDKLVIQTLIKQFAQTKPILSFLNQKKENFLKLIVISNAESLSKDAQAALRRTVETYSVNFRIVLMCNELLNIIEPLRSRCLTFRIPGFSNEYIKTRLEFILKKEDVYIDNEIIDEVVGKSRGNMRMAISLIECYSMSLNDKSGNKRQKSVNPTLDLEWEKSIKNIALTMKREQNASTLIKIRTELYDVLNSCIPPKYIIIRLLIEILSFVNKEEYFNICDSAALYNERLVLGSKSIFHLEGFVASCLYVLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K6</accession>
    <name>A0A4Q9M2K6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoacetylglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0003p0050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2K6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0050"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="9">
        <location>
            <begin position="484"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="7">
        <location>
            <begin position="797"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU21010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="847" mass="94976" checksum="ED1F145A1D0E8894" modified="2019-07-31" version="1">MPLSKKEILTYLTPLPKNLTKPQKPLFYGTAGYRAHASLLPPIVSRCALIAYLRSTTFAGKNIGIMLTASHNPEDQNGIKFIDHNGDMFDETWEKLCDEIVNSEDKDFYTVINRAHRKYGNMRDIGDGPRASLILGHDTRPSHTTLIQNIYDTLESFNIQITNYQLTTTPELHFLVRHSNLLSTLPPKNSYLDHLTNLYTQLKQALNDRDNKSDGDGDRDNKLDRDIDKDNIDRDNKIDNKLDRDNIIDKDNIIDSIDRNSIDRNSIDRNSIDRNSIDRNSIDKNSIIEEEVNNPNTTPLTTYVDTSNGVIEYKLLYLKNKIPLNYHIINKKGPLNYKCGSDYIKTYNLPPFNINTCIYDIDLCASFDGDADRIVYFYSSNRGGEGNRDGSSNRDNNSNTNKDKDNTKDKNNISNANTKDKNNINTNINTNKNNISNANTKDKNNINTNINTNTNISNNTNNTKDNINTPISNTNISNNISVIDGDSLAVLLITYIYTLINNTDITCGIILTYYSNTSLLDFLYNKGYKVSIVNTGVKNLVKAARLYDIGIYFESNGHGSVIFSERVRGMISSGGGIVGGSVVEGGIVRGVGSSLDGIDSNTSLVDSSEVRGNKGSEVNTLISNTPLSNTPPNNQHSNNTILNILSLFFDPCIGDALSNFLIINLLFKKEDFYKLNSLYLKYPNRLICIPVKNKSVLKVGISSGIGDSSRDSGRDSGRLDSSRDRSNTNRIDSNRIDSRLDSNRLDSRLDSNRLDSRLDSNRLDSRLDTNKLSSNVLEPVELKRRVEQICLQKEVIRVYIRPSGTEECIRVYVECRSVEECDKIVLCVAQDVYDLCGGIGPHPEIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Q7</accession>
    <name>A0A4Q9M4Q7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0051p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Q7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18841" checksum="E7A4911A025286CA" modified="2019-07-31" version="1">MKWILYVLLPNITSTGISSERKAYKRTCEQIKRQQQNNERSQNYIISNSKQGETVNFGPNNKRNKSRFYKKVKHAKNDNASTESEQEGNKKERKRNRKLRKKEDSKSKNDPLNKYLTSSRILKDDPTFDTIPKDEKMDGSGQSSHSCVTSEDYFADTSDFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5B4</accession>
    <name>A0A4Q9M5B4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-Gid-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0023p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5B4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0050"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="354"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="6">
        <location>
            <begin position="354"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="48056" checksum="37A8141C40799D52" modified="2019-07-31" version="1">MSQNNTTTTIDTLISDTLIQIEELQNKIKKNEDFEPNKSKILHLWKKASTEKYSDSEILFIKEEYFRSKECTDYLVVQYLLLQGNYDIVDTLISEICKIGIGEGKEDYRDGIDSNTSDNNTGDTNSIDKDIVNNIKDIININKDIVSNKDINNNKDITNITTNITTNINDNTYLIIRSLRDNHLDLMEMVNELKNGKFEKIEKFIEENKNLLRGKDLLFYYNCLQFITFTRNKWYKRGIIFARENLKEYFMSRQFNKRVKRLMCILSGTDYEVYWKYYLEKIVEQVCVDFCYLKNYPGTNILDILFRNGKNIFPELVQASANYFKQSVVTVDEEEIPVQVSVTEDGKFHSQFVCPVLKVLCENDNLPSLLECGHVISSKAVSKLSKNNTFVCFKCPYCPQESRTENIVTIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JTZ8</accession>
    <name>A0A4V2JTZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_1886p0010</name>
        <name evidence="10" type="ORF">CWI38_1431p0030</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001886">
        <property type="protein sequence ID" value="TBT98141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001431">
        <property type="protein sequence ID" value="TBU11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JTZ8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JTZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1886p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1431p0030"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT98141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="420" mass="48697" checksum="D24D422C86FC651E" modified="2019-07-31" version="1">MAKYLTRPSVAVSNNYSDNKNNDLILSEGDIISTSESKRFVVLSLLGTGTFGQVVKCRDSVRNEDVAIKIIKNDRAYYKHGISEVRLLSKLLERNVMEFFVEMKDAFIYKNHLCIVEEILGINLYQLLKYSNFKGFNHQNTKKMLVQILEGISILHSMGVTHCDLKPENILVLDMLDLRVKIIDFGSAFSEQQTTYFYVQSRYYRAPEVILGIPYNSSIDIWSFGCLAYELFTGHPLFSGKDNVDQIGKIVALLGYPPVFMLEHGKHVDKYFKNISNSTEICNKVNERKENEQILFKTTKKEFTLIKNVTHLTFSDVKNEIFLKSEGDEINTNFFIRFLLQCLTLNPLERPTAFEIRKDQYIQYDPSFETDESDRCVQPSPLPFDIDMRRNSINDVFTLLNTKKNKDTRKRSVYELPKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVH5</accession>
    <name>A0A4V2JVH5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0180p0050</name>
        <name evidence="12" type="ORF">CWI38_0365p0010</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="PITJ01000180">
        <property type="protein sequence ID" value="TBU04132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000365">
        <property type="protein sequence ID" value="TBU13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVH5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0180p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0365p0010"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="44"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU04132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="310" mass="36186" checksum="EDB47C792198B05E" modified="2019-07-31" version="1">MQKKQENYAMVVPSYPTNNVFDFEDTKTLSQEYRIPVDRPVRIYCDGIYDLFHYGHALSLKQAKNLFPSVYLLVGIPSDTVTQKLKGKTVLSAVERAESLIHCKYVDEVILDAPWVITLDFIKQHSIDFVAHDDIPYPGPNETEKDKKEENSTNSSSTDTTINQPKINKQENEIPINSYTTDIYAHLKKLNIFVPTKRTKGVSTSAIITRIVSDYDTFVRRNLERGISAKDLNISFLQESKFKMKKKVDKIIQNVDSDLKNEMREIKREIRVVIKYWENMSHKMIRNFLKKFDKKEEKNLWNKIVDIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVJ9</accession>
    <name>A0A4V2JVJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0232p0030</name>
        <name evidence="5" type="ORF">CWI38_0414p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000232">
        <property type="protein sequence ID" value="TBU03792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000414">
        <property type="protein sequence ID" value="TBU13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVJ9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0232p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0414p0020"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="120" mass="14099" checksum="23E05A7C34883AA7" modified="2019-07-31" version="1">MKIERDFFKVQSKEDLSKTILDLRSVLLSLRQKKASGNIEPNEMFEARKNLARAIGVLREKELLEEIDKYKDAAKLPKHLMPKLTKAKRLALTPKQLSMKVHRVRKTRKLFPKVYFSYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVN7</accession>
    <name>A0A4V2JVN7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(d)CMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0087p0040</name>
        <name evidence="11" type="ORF">CWI38_0288p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="2"/>
    <dbReference type="EMBL" id="PITJ01000087">
        <property type="protein sequence ID" value="TBU04802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000288">
        <property type="protein sequence ID" value="TBU17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVN7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0087p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0288p0020"/>
    <dbReference type="OrthoDB" id="10263145at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU04802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="223" mass="25288" checksum="EB6E8438D5883564" modified="2019-07-31" version="1">MCTFKIAIDGPAGVGKSSTACEVARILGFSRIDSGSIYRAVTFLLIKKFGSDIDITRKNEIEIFLKDMNISIKNERIFSNEEDLSKNLRDEIVEKKVALIAKESYIRDIVKEIQIKAANTSKSGIIIDGRDIGTVILPNANLKIFLTAKDEVRAKRRYEEYVEKSSVNFDTILDEIKKRDYEDINRKTAPLKCAEDAIIIDNSDMTFQEQVEIIVDLVKKKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWZ8</accession>
    <name>A0A4V2JWZ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase</fullName>
            <ecNumber evidence="2">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2110p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01002110">
        <property type="protein sequence ID" value="TBU09822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWZ8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2110p0010"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="3">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="4">
        <location>
            <begin position="166"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU09822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="41955" checksum="C9DC0A259CC789EE" modified="2019-07-31" version="1" fragment="single">MKVELQKAPKKSAMSLNALNIAEKPSVAKSISFTFCSSAKNIKSRHPTYVFPYSSYNMTFTSVLGHLFTLDFGNAPWSVDPFILFSAPIIQKPMHPNLLSHIKQQLHSKDLVIIWADCDREGENIADQIQKFIKEQNQTIPIHRARFSSIDSATLNYAISNLTIINQNESNAVNTRQELDLRIGAAFTRFQTLAINSKSVISYGPCQIPTLGLVVERGNHIKNFVPENQQEILIKIENNSSNKKSEYLFSWKKNNIYDKSFSKLIYKYFLKYPFIIQNTISTPKTRLRPLPTRTVDMIKALTSYLKLPSHKIMEMAESMYTRGYISYPRTETDSFPSNFNYKEILSELECEGEYKNYICKTFCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX58</accession>
    <name>A0A4V2JX58_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SKP1 component dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0709p0010</name>
        <name evidence="5" type="ORF">CWI38_1146p0030</name>
        <name evidence="4" type="ORF">CWI38_1764p0010</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000709">
        <property type="protein sequence ID" value="TBU01440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001764">
        <property type="protein sequence ID" value="TBU10432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001146">
        <property type="protein sequence ID" value="TBU11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX58"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0709p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1146p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1764p0010"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="2">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="161" mass="18493" checksum="0738C724DC2C027C" modified="2019-07-31" version="1">MINSTPLFIKTTDDQIIQIPIEKAKRSFFLSSVLQHTIIKNYIETPISSNTLALVLSFLDFNTIELSANYCPTEIRFTERDKLFLVPLTISQLVELSCAANYLDIPVLLEITCKTIAERLKDRTLEEIKDMVSVSRDEALNEQESKEIQRDFDWMSSSEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE4</accession>
    <name>A0A4V2JXE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1203p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001203">
        <property type="protein sequence ID" value="TBU11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1203p0010"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16803" checksum="CFF84F64351932C4" modified="2019-07-31" version="1">MIIDSKTIYVQQNNAKPHFSHNDTDVVALGSADDWNIKFKVQLANSPNLNVLGLGFFNSIQSLQYQASPHTIDELINLVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHLSKVKLRREGRLLEKYVCSKEEYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX9</accession>
    <name>A0A4V2JXX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5089 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0408p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000408">
        <property type="protein sequence ID" value="TBU13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0408p0030"/>
    <dbReference type="OrthoDB" id="2192459at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031547">
        <property type="entry name" value="DUF5089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17002">
        <property type="entry name" value="DUF5089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="23407" checksum="18C5794A2FDBC343" modified="2019-07-31" version="1" fragment="single">SIDEEIKRRAEELEAENYDVAKQARMKLEASGTQQKDTTGRLKSQGEKLRNIKGEAIEVHEGAVKGSKITKDIKREGKLFGFHVPLIGKIKHLFSSDRKIEKEVEVEKERLKHKKNRSTERIQEISSDDEHFNQNSDDEVVKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENSEQIMDRTTEELKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA9</accession>
    <name>A0A4V2JYA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RAS-related GTP-binding protein Rab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0068p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0030"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="23986" checksum="F6B1C00DD0A17305" modified="2019-07-31" version="1">MSTSVKKTSEKYDYLFKIVLIGDSGVGKTNLLSKLTKDVFSTDSKATIGVEFATMSFDLKDAVIKAQIWDTAGQERYRAITSAYYRGTLGALIVYDVTKKITFKSAINQWLDQLRQHSQENISIMLIGNKTDLENQREVTKAQGNDIAVQNNLSFIETSAYSGENVAEAFKQLVVKVYEINKAKEQANMRKGMVKNQYKGVPLRKPKKKNSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL5</accession>
    <name>A0A4V6MVL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1129p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001129">
        <property type="protein sequence ID" value="TBU11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1129p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="420" mass="48137" checksum="3FAA86B198D7AEEC" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEILKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNEPVPSSVEVSACEPSYDMTNPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFALHRYYNEKFGCTETPEVLKKLAQSEMRKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLIMRASSITEAAYIMQAAQVCYDEATRKEKPRSDWKENIESKISKLVLSKDLLEKARKQDKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP7</accession>
    <name>A0A4V6MVP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0113p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000113">
        <property type="protein sequence ID" value="TBU20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0113p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6006" checksum="DEF24A604BFBD3B2" modified="2019-07-31" version="1">MFSISKYFSTEDLNERKSEKEKEKVQLASNFLNPSILLIKIHCYILLKCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KQY3</accession>
    <name>A0A4Q9KQY3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2520p0010</name>
        <name evidence="2" type="ORF">CWI38_0012p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002520">
        <property type="protein sequence ID" value="TBT97073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000012">
        <property type="protein sequence ID" value="TBU20885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KQY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2520p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0012p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8783" checksum="2B6FA1AE4A0F91EF" modified="2019-07-31" version="1">MTNPSYITIICKNQTIKQRITLLSNSSIEDLKNILSKKIHSHTSAIILQRGKEQLRNDLQLDILGIVDGACLEIYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1Y0</accession>
    <name>A0A4Q9L1Y0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0720p0020</name>
        <name evidence="3" type="ORF">CWI38_1039p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000720">
        <property type="protein sequence ID" value="TBU01394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001039">
        <property type="protein sequence ID" value="TBU11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1Y0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1Y0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0720p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1039p0030"/>
    <dbReference type="OrthoDB" id="2189967at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="124" mass="15104" checksum="291B7BDB6AEFDCFE" modified="2019-07-31" version="1">MTNSDIFEISIQKHIYLPEKNCTVYEIVCITNSDHFEKCHSRVLRRYSEFRALHYKMKKDIPALPQFPSKCLNRLNYNVVQERHYMLNAYIKYLGELFFEKKNFNEKWAKCFVEFITNSEYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7F7</accession>
    <name>A0A4Q9L7F7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome complex exonuclease Rrp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0271p0010</name>
        <name evidence="6" type="ORF">CWI38_0271p0040</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000271">
        <property type="protein sequence ID" value="TBU03587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000271">
        <property type="protein sequence ID" value="TBU17666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7F7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7F7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0271p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0271p0040"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="4">
        <location>
            <begin position="348"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU17666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="802" mass="92126" checksum="5153B73853129224" modified="2019-07-31" version="1">MKEILEKCTELIRAVNSTIARTNRYQMNDSSLNENNSIAESITKISELLNKFDENFFDKTTARIDHILCNLNKQPVHSKIIKIIKDKKVIFYFGDGNAKPLNVEFPILNLNCTHLLKKSDFLELENNFYFKTWFSKSKGKQFVPTTEFLHVNYTPIFINSSAQISFIEEAIKSEKIICVDVKQHTFRSFRGYTTYLLLLSPSHSFIIDAVTLQYEIPKLSFLNCSIKKIVPNTNCLEILKRDFNLEMGCVYNLEKDNNYRSVIVDWRINPLTEELYDFAFEKIFNSIIKIKEDLSENDCEGRSSFRITPITEEGIDMATINNLTPIKTGISEIDEKELARIFSRKYNFYNDGELLGKILKLRYFIAKSEDESLQFVMTDEQVQNVVVNKPSNIEQFFSCFDRISPLVRIHISDFLLTIKEKKSGFDIDKLKSLKTNENTDLETKEFMNSKTKISDSSNNFGPETKKTCFDLQDSQNRDCNNIKSDEDFSINSSNLDGNLDKELNTFKISNDDLTSQNNYSLNMNESTQQMSLDVKKSNFSEVIAGLNINEQSIETEIQNESALSSANRVSKKEKKNGTKNTKEKPKKPNPVSSKDNLNTQKSSKNISSETLPVNKSPSNTINNSDKSKHDKVTDQNSNIYKNSKVKNNKISTVDPKKSTVSQNSTRKQPTAPKNSKFKNNHLIFADSDDKKEISTDKIQNKNLKDIPQSTATSNKNDIKDEKILKSKIENKKTNNKKKPNNKSKNDVSDKKCKNLNKTKNNKNKSVDDKDKEKMSKNEKEDVKKQKDENPFDSLKNILDRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9F2</accession>
    <name>A0A4Q9L9F2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0147p0010</name>
        <name evidence="5" type="ORF">CWI38_0032p0080</name>
        <name evidence="4" type="ORF">CWI38_0048p0050</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000147">
        <property type="protein sequence ID" value="TBU04353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9F2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0147p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445417" evidence="2">
        <location>
            <begin position="24"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="766" mass="89689" checksum="20D0A7F9D4BE60F9" modified="2019-07-31" version="1">MEDSMNKVSYGLIFLFLKTVLVSYPYQQVYPTENCTSSNPTYPQQNNFGLYHPNFTNFYGNIGNSAINSTVYSPSSFSANFHRFRPYDIFPRNITFPTNNSENIPSFLIHQPFPFYNSFHPYWPSYRQSEMFLQNYSTIYSETNAASIPPIYNQNYTAHDRLAEQRINPEPPRNIQVETNVSDDILNIQSGALQTNSIINSICSSSEAQRTFNTINTENEMQNIIDKAKTNNARSSTNQESGKMSESSNQDKICFENRTNTDVDNRSRTLENQIREMLHKMEKYIATANNLALIPLFVDKDSLQTNIKSVGDKIREFSMTRFRNSDKYLLISMYVMQRTYEYNFKNFKHLLNTGSINANNTLFPKCLFERFKGSKNHFSESRNKELEICSSLILSGLKSTISNFYPSLATNTDHNSEKNLISNDELNLKFQNELKNIEKNISNQEYFVNICSCFNDIEEKSFDSMFALEKIKNILKINSIYDILNLLTNSTQTILVYEIKVFLNLYSKDIEKRIKKNHVISMCFFLKALVNYFGNINLEKLYLTKNKNQERAEKIKLLRLEVCKKLFFVGKLFENLLRCLKNHETKANFYGLLNVCRFHNLILKSYTNDVTLFSLQIPLYISMILELSIDFDSETTIEFISFILFVVKQEKLTYADFYNDKFEYFLEKSNVNVKNIIKKNHDFTAKDNIYSQSTADMDNCTIIAKDFLDRDKTKNNKNRRLKTLYISQLNYMVLLKKKNLCFLSNLKYSNKFFEKINQRIEQFYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9J1</accession>
    <name>A0A4Q9L9J1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0145p0040</name>
        <name evidence="9" type="ORF">CWI38_0951p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000145">
        <property type="protein sequence ID" value="TBU04368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000951">
        <property type="protein sequence ID" value="TBU11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9J1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0145p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0951p0020"/>
    <dbReference type="OrthoDB" id="2186239at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU04368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="279" mass="32160" checksum="984ADE47ADF02D3B" modified="2019-07-31" version="1">MSQEIKEFGDYSLVCQLGVGRFGRVYEYIDRVTEKRVAIKFVSKYLISFGKPDFIPNEIKAYQFLGKHPNILEFYGYTELEEEGVFILEYFNGYSLQRVLYESRNHNKRPEVTNSLLKGYVLQLIDAVKFIHSHCIYHCDLRPENVLVNNSKIKIVDFGCALFGPSVFASSRQTLFSGSANFLPPEALSLSKDSEFLVLKPCVDVWAIGCLIFYMYTGELPFNGLHYEEALTQVRNLQVDFKGLPSFIKPICQSIFQADFYKRPNLEELEVIVMDMIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDX7</accession>
    <name>A0A4Q9LDX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2709p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002709">
        <property type="protein sequence ID" value="TBU05766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2709p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="205" mass="24314" checksum="0B10111DA061B872" modified="2019-07-31" version="1" fragment="single">SYQRTQMDYVIVANFIIFFAKDIVKLFEHEKNELTVFLTLICNLRNFSLSCAEIASFSDKPVKTYVNLSVIAMFSQLKIEDQNDAVIVDLKNEISRNFFVSFLYSQSNWLNNISRFYGTGYNFFYEFKFIEHLLCRQYGISYLKGECYYYNLLMYLLDNNIFISDIFDRDELLYVARSLRSNNAFGNTSKECSELIRIIEYFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF34</accession>
    <name>A0A4Q9LF34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2537p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002537">
        <property type="protein sequence ID" value="TBU06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2537p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21325" checksum="2C63E5771FB5E23F" modified="2019-07-31" version="1" fragment="single">EFAKKKLFIIFVCLCRNALSRKLNEKHTKVTIHNAADSHTTKNLLFINDIRLLVVESFTLGAMTGAVKEFLMKIAHKNRDKSALKDTFGEDTATLLVVLYLYLARTEPGRGLHSENFRRYLNYIWKKKKKTSIKGINARKKKRASMFCYTQDRNILWVADGVQNSIHLELDVRKCSERLNYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHD5</accession>
    <name>A0A4Q9LHD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2541p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002541">
        <property type="protein sequence ID" value="TBU06601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHD5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2541p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="47234" checksum="8CACA52720650469" modified="2019-07-31" version="1">MIFKKHSEDKFLRISVFFMQVCFAITISDLDFIDLPSPYFSIVNGSKQNTYIMEKKINSGTYGMVFLAHKEANKEKVAVKVQRTFIYDYFGVTRDVLFTSILKHENIVEIHCFDIFGPNEYSVYEYIPNTFHDLLSTNTVDFSEFLFLIKQILDALNYLRTKNIIYFDLKGNNIMVKENFQLKLIDFGMSTFKESQFNIFNELSKKKGKLSDFDHLLYSPEVKAGKNFDHKADIWSLGILFMKYFKIYEKNLPDDLYLIAKSFFEKCTSEDKKSRFSADQALMHPIFNDLFHFVFCFASLDDFFYTKESISLVKRGKTIYFRNTNFCFEIHCCCVNSNRFHNFISSITQIINICCFGSKKLNHKNLAKFTVILNSQKIPLQHLTFSYYQQLICIFEILNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHL4</accession>
    <name>A0A4Q9LHL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2570p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002570">
        <property type="protein sequence ID" value="TBU06470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2570p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="23537" checksum="EF869668A0924B3E" modified="2019-07-31" version="1" fragment="single">MYAKSKFSTKNTYLIVILAIFGFLQVIDCVRIIVSFDTLKRQNCLIVNSFNSFNPTNINNSKESVQAESYIYPHNRCSFSATPNCSSKDIQHEENDSNKRRRLNDANKPENTHCNFRGPNSHTNDDVCTGGDIDQNSPALFSFGNRTTIETAIKFPGDIQIVLTCEPINIVTFDYSENYMIRSKYFDEFNNVKTSKKEIKIQDISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKL2</accession>
    <name>A0A4Q9LKL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative SWIB/MDM2 domain-containing transcription activation complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2244p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002244">
        <property type="protein sequence ID" value="TBU08567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKL2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2244p0010"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="1">
        <location>
            <begin position="155"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="498" mass="57895" checksum="74351987087C613B" modified="2019-07-31" version="1">MMNLYNHLKKMEKLMDNAALKRKLMIEDSHCSRLKCIKTLRIFISISLNPFLLKIEGRVINDYKNNVTVKTSALLKRIYVEFNNTEQKSEDIAEVMVYDNKDILCPPISEIPIDHIKEDIIDSFEWIRSDKHIDGFELKTDKTPNSIQISFQFDNSINKYKVSQNLAEVINRHTDSKSEIILETWKYIRLNRLIGSKGKDIVVCDDKLKKCFDCDTFDICQLSMYVDRCLLPLDYLTIDVPVTNGYTRVFDVRMECDDLVDFPIIYTNKTILALDRKINDILELIKKTEERKELLEKFAQNPKKFIDEWIVLQSKDLNVIEDNPDFQTDFFYQPIKSASNDKCCEDTATLLEGISVYKYLGIKEDSKGIRNVAHLGKLNAKNLFSAINQHAISLINYHIGLDDAVRAVLVKNKLHLRPGSLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKLLKVKYRLVEELVSVSDSSRWLKKGNIRPRNEAVFCYIQDRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLF0</accession>
    <name>A0A4Q9LLF0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2207p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="PITK01002207">
        <property type="protein sequence ID" value="TBU08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLF0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2207p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="41352" checksum="EDC96D6E2272F172" modified="2019-07-31" version="1">MDLDKILENLKKCILPTENDLFLILKSLNILHYDEPNTLELSGSFTLVGDLHGQYFDLLNLFDLNGWPSESRNYVFLGDYVDRGAHSVEIFILLSVIKLKYSDSVFLLRGNHETENLNSVYGFKKEVLNKYNLVFYKLFCESMQFMAICALITVCDKNCGCTGCEGILNESYSEKNNSFPKNNNILIDESCEDIFAAKNLPGKSMNTKNLNGCDICKGLSNSNTENKFKVFAVHGGLSPKYDQINQINKFNRMLNHSNLHDLLWSDPSEEPGYKKNTRGAGYLFGEDIVNKFCKNNNISLIVRSHQLVQDGFELKFDGKLANIWSAPNYCYMCGNLASVIVLKKGGFEEIIYDKCDNQLGNNIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMD9</accession>
    <name>A0A4Q9LMD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2241p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002241">
        <property type="protein sequence ID" value="TBU08591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2241p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="640" mass="76531" checksum="29C10B4B6CAC342B" modified="2019-07-31" version="1" fragment="single">MSLYLYFGKRKEPGAKKSYLQTFVVLICFYFPLCFTTVSFFILNDQNTIYRLNAIDLTLEMSKIENKPMKYFIGEDIITRFENNILGYEFANGRTKYYNPNILTIPYENDILLSSNFIKTLFESKQTNINIFLKDVSHYSLVLFIKLIENPDIIVNQIRIQEFLDILIIISILDIKKSKERNDFLKELLKNFMFTMEEVNLTFDFEKSCERYHHKYIKKSILMDLLIFYFDFITFNDKSAKRCMILSGNKYLRFNSCDILFNTYISYKKGTKRLYLRLNDISIKKIYKMLGIGYLLNTWRLLLCITEFDLLYLMFSEEYTNTKARKLFNDVTFHTNKLYSHFTENLIRLFSKKQLSVFSTNLKVLKLEFNSSADELKKILLLSKNLQKLTLSTKNFDFERLRLLVNFSLENPKILCNIYSLNYEFRDIDFEFLNDIPNNCMFYAYNFTNESKKLGIDIQYKQFVRLYRYSYDETSNFTTNFVHFEWSKYKYIELNYDSSSTPLKLDNSVFKSLSYMNTIKYFLLQNIVITDELLLFVLRSTTIVYFGIRTFIYTNDYRFISDGNIINQKLAAFDLINSYSPIHTSLLVYLKRFRNVEVLKLKNICINHTELCFREIFKDFSCKNLSENKIYLKSLKIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMP6</accession>
    <name>A0A4Q9LMP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit Rpb5 of DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1457p0020</name>
        <name evidence="5" type="ORF">CWI38_2154p0010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002154">
        <property type="protein sequence ID" value="TBU09397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001457">
        <property type="protein sequence ID" value="TBU10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMP6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1457p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2154p0010"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU09397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="21994" checksum="871B130EF75FD70B" modified="2019-07-31" version="1">MTEISEKLLLCKNTLIEMLTDREYIIDTRLLENSTELKMLVHHKKTNAQLLVHYCDEAKVGIKTLKMLIESFEKQDISHILLICKEALSPASSRLIEEYNSKFTIEVFKERELLFNVTKHELVPKHILLSENEKEIFLKNRKLKEQELPKILKSDPVARYYGAKRGQVFEILRKSESAGTALYYRVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMV9</accession>
    <name>A0A4Q9LMV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2214p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002214">
        <property type="protein sequence ID" value="TBU08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2214p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117744" checksum="8E8C4DD4C148DC1E" modified="2019-07-31" version="1" fragment="single">MYLLHKPLKNSKQFTKKIICNDFLGNSSYKTVILVKNESLEFYELNTNGTLIYVNEIPVFSSIQQIQIYFYKKAYLCITSGGCITILEVVKCCRNEGSSINDSINDSNTKTNTNCTTENPYTDIYTTKLIDTLVYDYSSTQIGYYFEISSNCFSVGSINGNFIFTDYKNLKFKNCLKFKSYSVVYSFKAIKGMNNYFCMLERRLGSGVRGEGDVGESSNRESSIRESSIRESSNRGSSTRESSIRETSIRESSIRETSIRETSIRKDNKNKEDNKNKDKDDNKDINTNKDHNTNKDNNTNKDNNTKKDNNNSHDITGYMVIRIVEYLEDTVVIRNVVNVMRCAYNILTFEKMYWVCVGREEVCVFSGWRCVGRGKVFFGGIFVCGSEIVMKNKKSFILMVDDKGGVYSIEIGGGDREGGSDKGRGVSYGTNEQHPVNNISYKQQGVSNNTNKHPVSNSTREQQGVNLRIYFYDKIRGVKDIFIHPMGFLICLGDKDYNCVYHIKGVKGYLVWDIKSVSSIEGVSDKDSIQQGVSNNIDEQHLFNNTAYKQQGVKISTNKQQGVSNNIDEQHLFNNTPYKQQGVTGNLFLTHKIDGYFAIKNVFLNFSEKSKNIFLTKKGKFYKYLLKSPLIRTEDSIISFINTVYNKIDRSKDIDMGIVINRDIDNNIDNNIYIRDINTNIGTNVNSKGINTNIGYKDTTTNIDTNTNNSKGINTNTNINTNIGYKDTNTNIETNANNSKGTNTKDTNINTNTNIYNINTTSPLKNIFFFTDSFIVVTDTSIKYFENNFLKSFSLKFRKNIKEIKKIKDLIIVLTSKEIDIYLDIEKERDRNTGIRDISNTKLNTSNISNISNISNISNISNISNISSISNISNISNNNNINITTNISNTNISNTNISNANNNILTIDILYHCYTSTDTSIVLLYNNKIQIYFFDTNIEEKYILKTINVEFKIIYIQIYYNYLFLCTGLSVIRIFNIFSKKYVFIQIFKNNIILIKVINNKLYVVDDKGILHIINISMNGDKNGDGDIGSRDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN44</accession>
    <name>A0A4Q9LN44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2114p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002114">
        <property type="protein sequence ID" value="TBU09799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2114p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="517" mass="61219" checksum="6307E1F7B5AE4591" modified="2019-07-31" version="1" fragment="single">QYMICGMIYGAMKKGAELRKDWQEDLNESVRKAWMQDCLRDSINPSTRLPDKRFCFITTNSMEDFFDFFYIFEPGFRCIKESIFDTIDFITEQNIEEIQKQVKENLMKENIKREVFLNTVLSRFGSLVIEKLKSFLHNKFSQILEENKSNADLFENAFLVLDQENNKLTSEFKKKYEEELIQACSDDTKEGNISDLLHAINSLFFLYDYGVILISRFFQVLYIKSEKDIYFNFFRKTNEDCIAIEKEKNLIYRRLKSQRERIEYDADINNIFVPFSSKHVRYKYIKICLDFCRRTARISLNAKLGKSNPRLLFTGILTDELKIFRPAFMFSESAIYFGYGFCNKTISDFIEYGGINANLRIFQFSYIDLSFFFPEFLLNYADQLIGSSEAKSLNEIASKEHACLSDQTKKLIDHSSFNKSICADFLHEICKVYVKRKNFNSKLYISAFEISLESFKEIYYSFIKELKKNQERFLVSDQEIEKCRDFFLRCILYKIKNITNCFKLTNVPAIDVEIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNQ6</accession>
    <name>A0A4Q9LNQ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2067p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002067">
        <property type="protein sequence ID" value="TBU10048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2067p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22893" checksum="F8FDD76B3979757C" modified="2019-07-31" version="1" fragment="single">KIRNNRPDIFILVKKKNKITHIEVGITSQDALQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEILTNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKNLKPKNNTPLISQGGTTLQEPTNNINEESDLEKETVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP22</accession>
    <name>A0A4Q9LP22_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent DNA helicase CHL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1971p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001971">
        <property type="protein sequence ID" value="TBU10168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP22"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1971p0020"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="35012" checksum="AFD05098F0A2B8A3" modified="2019-07-31" version="1" fragment="single">MTLEELKGNLYEIQKDFIEKAKCVIENNEIGIFSSPTGTGKTISLLLSVYNYFIPPKEESNKYTYFGLNSENKKLMEQLFGQSDRITKVFYCSRTHTQLNQAINELKRFDSNVNSIILGSRKLYCVNKKVNKTNVELEIINEQCKALISKNDCEFYCNFESQNETDIIDIEELIKKGKEKKFCPYYFAKIYSKKCEIVFLPYTVLFSKEGRRSANIDISDSIIIVDEAHNIYESVIQMNTVTISFEIVKKYFKAFEDYYLKYESRMSEVNLKRIKNICEILEKIWKFHENFANNLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP73</accession>
    <name>A0A4Q9LP73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2162p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002162">
        <property type="protein sequence ID" value="TBU09311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2162p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="43937" checksum="447C7FA000BFBF70" modified="2019-07-31" version="1" fragment="single">YTNNISCNDWSVSTLGVITEITVSNRFIGIVSKLEGVNYIISIYMLKGKKIIEIGLVNIKGVNSYEYKLGVIYNTNILKVLDIRTLKSKNINLLYNIERCYFSEEGYIFVWGNGFLYKVVDKLCVLLQRIEGVVLCVSGGCCIVYGKGMCVYPLEVEYIRIVDERLAGNEENILKEFKNIIEGVGVGVGCDVGVGCDIKDIKDTSSVNIKDIRSDGGNVKNLNYDLVELLGLMSNKENIKYCKDILYRRGYKEEREESSEEVKHFREYKSVNDSSVSNPVGYNNIYKTSNDNSIHSSNNISNDPSIHTSNANSISNANNNSNNIYSSNSIYSSNANSISNDLSIYTSNNISNNYTSLGDSVSKSQNLFEFETENLKKIKSKKYNPYSENRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPA9</accession>
    <name>A0A4Q9LPA9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1864p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001864">
        <property type="protein sequence ID" value="TBU10303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPA9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1864p0010"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="8347" checksum="8D9A30FCB16B452D" modified="2019-07-31" version="1" fragment="single">MIKNEMKINKTKTNTIYVTNVDTNITYLVLHELFTQTGKIKNLKYPTDKITLKHLGYCYVQYFTEEDCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPD7</accession>
    <name>A0A4Q9LPD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1876p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001876">
        <property type="protein sequence ID" value="TBU10288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1876p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="14022" checksum="C439EDB9E8424D77" modified="2019-07-31" version="1">MFLFINLSLQINWKSTLQKFIENECQIRNNRPDIFILDKKKNRITLIEYDLLANEFGLIFMFGVEIIPYSQPKRLQIPHNVEAYIQSRVVKRHSKQFPVLEPTMNINEVSDLEKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPE9</accession>
    <name>A0A4Q9LPE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2050p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002050">
        <property type="protein sequence ID" value="TBU10067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPE9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2050p0010"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="19991" checksum="35411864563949E7" modified="2019-07-31" version="1" fragment="single">NGKIELECGDIKGIIKIKPSKSRDEINVCGSVKQKNKTVYSFKGIWDKYLLCRDMDTGNEFYVYESNERRFPEYYNMTKYSFQLNFITSEIESKMFYTDSRYRPDTRALEYGQFANALENNEIIENRQRVRKNESRPLKPRFFEFNNNLWTWKGCDDTGKGERIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPM5</accession>
    <name>A0A4Q9LPM5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1799p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001799">
        <property type="protein sequence ID" value="TBU10388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPM5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1799p0010"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF444">
        <property type="entry name" value="HECT DOMAIN CONTAINING UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="673"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1003" mass="119736" checksum="B6B3E4BE6B4434AB" modified="2019-07-31" version="1">MFYRATNEIVFKLIDDICTKLSDYDNIEFFSMISFIHKVFLSEICCCKYSLNSNEEKVNLIDSNCEKNFLERRSQIFGRFLKKGLLDILVTAYEKFDLSQSCIMKIIGLITIIIDTREFILNNTCFVTKIFRIKSSMEHIVFIPKFLEKSNFTEIHMQKNGSVPILKSKKNIFKQIDYTKYLRLDFGYLKGKHSNSKILHDFAFNDKNLHIKEFNNDLEDLDSFKLLSKLFCVNLHGKMFDKTIKKIYPENSSTVRDEYDASDLENIHFNFLGTYLQDISCEDGFKTHKLSNIGKEERFKFSDFLTEEKLSNIFLRLLIFFKGRKEACILNNIKSIISVCSNHKLLGSFNYFLIKNIETYEKVQNDQIISYRLEILRLIVIDYQFIIRFKTDSLNFNVLIFVLIDKTNEYFLKFDRKTHLRSLISIFLSENISNENSFVEFLLLNMNQINEKHLSLGFYFGLKTILFYVEMMKDKICKIFLPFDNDKENNLDFFVFKEFETFLEKFHDFKFELTVDFLEEIIDYSIKLSQEYLAGILIELFKDGVVAIEYIFKYTWMYFLKVSEQDKFERLRNHLILKYLMAFIFNITYQTFYETINEDNDCIEVEDLDRELSKLYNFKLFENLLQNIFHYTDIETKKLILRNKFNRSEYYFRGINFKVTRSEIFNSTINILSQSNLMEIRYSMWFITFRYESGQGIGLIYDFFTLFGKEVNQNKYFEAFRTLDYYDISNLNNENENFIKKAYYFLGIIMAKCVAMNYVLGLELIDSFYLYSLKDKVTFEDLKYLDYEFYENINKCNLSDDIDSFGLYFTVNIDNLDNEYELKPNGSNISVTTSNLKEYLQLITEFKLFKNMNKYLKEMKKGFKFILNEYLSFLFTLDELKLFIEGERAINIDEWMSSTNYIGDYHKDHHVIVWFWKFVKSSNEEIRKKILYFVTALEKLPIGGFQSQKFILKGFSIESTPCKELFPSSQTCVNLLILPCYDDEETLIKKFMIALENKEYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPM9</accession>
    <name>A0A4Q9LPM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1863p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001863">
        <property type="protein sequence ID" value="TBU10304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1863p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="22537" checksum="5D4650C663C66103" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAITLPSSSYTTIKPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRTVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN6</accession>
    <name>A0A4Q9LPN6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1790p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001790">
        <property type="protein sequence ID" value="TBU10399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1790p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="66939" checksum="E92DEC7C900EC4CE" modified="2019-07-31" version="1" fragment="single">KYIFYDENLILLEKNNETYNKKHFDKHIPYKSLLINSYKAFQILENILNNPNILHMLEFLLNEMNIKSIIFDNFQIFKILDSNMKIYILSMNIFKSITISHFKWSSSWLFLRKHIFSDKKNIEFLSLKNLKISKSDLEVICKKQKFKGLVLHNIKILENTNKNDLFFGLGVRLEYINFKNVEIYEGWWKEFFQLVHIRIIIISFYTYSSQEKFIKEFIRGNTPNELLYLELDFCYSSISKDFCNSLHHFKSLITLKLYGYQLDQNTHFFSHAFESMDKLENLTVQSCDFNRDLFNSFFQKRSLKSLHFQSLSAKKEILKIDLLDNYKSLLKLNLWNLKINETSLIEIFKLENLILLSLNFCTFETNRNSNSIYFKSKNLKSLYLNDIDLANIYTPELFNNLEHLERLDLSFCKLKPSNLIKLNFMCNSTLKIFSFESGVVDSNYIERLRDFEILNALNLSRCKLYKCSFCELGTACRFFITLEYLNLSHVKTNINDLAYLKFFKNLKNLYISLSDFYLSENFFYVLLPIKKFFKKNLFIETNSTMVSKYIYEENPNDGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ99</accession>
    <name>A0A4Q9LQ99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1833p0010</name>
        <name evidence="4" type="ORF">CWI38_1644p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001833">
        <property type="protein sequence ID" value="TBT98253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001644">
        <property type="protein sequence ID" value="TBU10618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ99"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1833p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1644p0010"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="120" mass="13868" checksum="4804D3A5EB3F7077" modified="2019-07-31" version="1">MKPKSKKRSDNLTRSITFAEEGVSVYGQIVRPFGNYRFEVRCSDMITRNCILRGKMLKRDWVQPNDIVLINLREDTPEKGDVLLKYTPAEVKVLRKNKYIPDTFGEEVIGGLSNVEFENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN2</accession>
    <name>A0A4Q9LQN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1539p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001539">
        <property type="protein sequence ID" value="TBU10809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1539p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="380" mass="45315" checksum="0428B93554D2F17B" modified="2019-07-31" version="1">MKSKTILYIFLGILLSIGGVISVLWIIYNEINLVEKEVIEQLRKDTIYVKNKFDNQKEYSSHGSNCFDISPLQTKIISFLKFTNDQIIYITDQNYEKNDYDAILFCTDSNIRYLNDLDKLKNERVKRFFLEKFIYNIECQSIIGLKNSYEPHYKSAMVFLDQHILKPFKFNSIFLKLCEKFRGKRYIFSRFLEVFKISEISEKTGEGNIFIHHKEGRIHGPYYSQRNEFNFIVFFDYEIFIYKFSREKNTEDKFEKHRNLCFFKDLYAILQINLHSDLEEETKVVKEEESFSKLVSNIRNEEAYEPELNVAGLKLSVIGVFERAGCINNHTPFKAWGFNHKVSGIPLNLRLVYAFLMKNRLNFRKFVVYLKKLNIFFEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB9</accession>
    <name>A0A4Q9LRB9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1372p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001372">
        <property type="protein sequence ID" value="TBU11123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1372p0020"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="4">
        <location>
            <begin position="434"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="619" mass="69739" checksum="1824359EA25E452C" modified="2019-07-31" version="1" fragment="single">MEINSQNKRLKQTNKTLLQKALHYKIPINIYGTHPHTLISPHFFTIDLRQYTDLSTLIYTVHLTSTHLQYTEGLLTTACKYGYVTVITHTDTNPSIIDYLKPLFNGLLNISNEKFENEIQDGLYNENNRYNGNGLKENNGYNSNGLKESDNNTSCGNSTYNTTPLNNNNTINTPLTNNNTINTPLTNNNTINTPLTDNNTINTPLTNNNTINTPLTKNNTINTPLNNNNTINTLSSILSPFYNPHPNFRIIFTSSTKLQSNNTVHIGPVTYTLPLTPLISLLNTFYPFNKPPTLQDTYFITRLTNRLQSLSLYTAIQQTYIITLKTLKEQKEVEEKIKGFNIEDIDNNTPLVECTYNNTPLNNRTYDNTPYSSTFITNTPLNNNSINNTPLNNKYINKTPLSTNPINNTPSFAPTSQSLVTLSALSSCILYNEPVLLIGETGVGKTHLIQHLSNINNKYLYIYNMSSDTDVSDLLGFYTSVHPISVIEEYVGNIIKREINETPLCYLERIERYINDNRETEGVNDSSKEEGVNDNRETEGVNDSSSNYKGVNDSSETEGVNDSSTNYKGVNDSSTNYKGVSNGTNNYQPFNNSTNMYHPFNNSTNNYNPLNNSTNYNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG7</accession>
    <name>A0A4Q9LRG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1388p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001388">
        <property type="protein sequence ID" value="TBU11098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1388p0020"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="128" mass="14774" checksum="688D69C7D45414F8" modified="2019-07-31" version="1">MLGLIYKCSVEIIPYVMTWDEYVTKYHKSHLKRLEIPMNVEAYIQSIVPKKTVETISFDRRRGLESRPNAEESWETTPPLKQLDNEDDGVKTENTKNILPLILDGITKQRNQQLIQIKSVSGGRDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI6</accession>
    <name>A0A4Q9LRI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1608p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001608">
        <property type="protein sequence ID" value="TBU10686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1608p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="460" mass="54698" checksum="72B151FF040CECFD" modified="2019-07-31" version="1">MIIFNYIATGTRKHPKKDKNSISIAQASENLKYEIRNHNEVNSFALFYGKKYIAKILSDKNLRTNTIPRLIFKINESDQNIFENDNRAIYLLCFTEIHSILLEQKTKLFYNNFAISNLNEMEKNVHNKIFQEIEYSLQRLSISNRNLEFTELFISKLQEYDTDEVSIIITYIYNKLIKILYRILNHSDDYKNIRIFLEKKNSDLLSYDRDLTGNTIFKKTIFDAKFLENGNDEKIIQTQIMSSIINSYKFLSNNMSPPDFKKSNNYRVFFKGLETCNLFELNPNESIEYGKKGFIDFLNFFKKIKIRSSYDQFEILKSLKNINFFEKIFKKNRSTTFEHFYLIFEIFSELLKVIDRNFDFNYDVHLVFEDLARIDLRDVIKEHYNTHLASKAGSSSRFTTCETRIFDIETRLISMFVMVFRDLLDHIFCDKSPKISKNIENFNDEISLEDSLKAIVLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS7</accession>
    <name>A0A4Q9LRS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1358p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001358">
        <property type="protein sequence ID" value="TBU11144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1358p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15212" checksum="4D1E6944146FD124" modified="2019-07-31" version="1" fragment="single">FSFLTEETCDSPSLPFLLKSLKNLEKVYLNGDHIYKILFLKNFSQFIAPKTLKVVSIISKYSMKSCQNFDFDTDIIEIYLWTLSLYGFYIGKNDKKMLGNLENLISFDLINCFLLENSFSELFDEEKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD8</accession>
    <name>A0A4Q9LSD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1200p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001200">
        <property type="protein sequence ID" value="TBU11449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1200p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="43538" checksum="EEA7829D65A0BC03" modified="2019-07-31" version="1">MNLPCTFKSENVHIYKNFEYKYLNWEITGIFIRKHFFEAKMDSNSLIDLNIYLYKVDFVNIFFKNKYIYNNIKILEISNSNIAYNSLKFLLLFPNLKKLKMTNNNILYSEVNKIFETNMSIVSFEFEGIQMPSLKNFLQFIKSMKNLKNLSIKYQFGRNTLAFSEIEEFFRSEIDYFSFISCEDIHMGVFLLSVFSVKHNIELTSSCELGNLKANFSYDGFKNIRSIKISSIKIDETAINVFENLRRLERIELRPSEHLPIHFYKFFSSSCIYNLKVVILRGMKIVNIDIIFFSKSKNLEILEFNECHFNNISYIYFAKTNFIYLKLLKFLSYDCRFSKDFYDFLNEEYSENILHFEMNEIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF4</accession>
    <name>A0A4Q9LSF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative replication protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1753p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001753">
        <property type="protein sequence ID" value="TBU10450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1753p0030"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="5">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24425" checksum="790CAF0E65FE36CE" modified="2019-07-31" version="1" fragment="single">VSSSLRTIRSFTIKQILNSPVEEPSTDYRIDDVEVTNLQIMGFVRSTRVNTTGTIFNVEDTTGSIECAFWPRGLFEEETVGLIEPPNLLKVVGSIRVFNGVKTIGASFISKIDDTNFFIKHFVECIFQHMFYLKTLKLTKNVKKSENKSFAKIKEDIINCYRCNQDERGIHVDIVVGMLKDKYPEQEVRENIEALLNDCHLYSVEGLEYHTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF7</accession>
    <name>A0A4Q9LSF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RBBP4-like histone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1172p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001172">
        <property type="protein sequence ID" value="TBU11503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1172p0040"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="288" mass="32251" checksum="BDE24662C9F01118" modified="2019-07-31" version="1" fragment="single">MTEEIDSFNNLEHKMINEEYKTWRKNVPYLYDILLTHALNWPSLSIQWFPDSIRNESNNTTTQRLLLSTHTSNSDTEYIKIVSVTFPDEIIEGYEGYEGSGFDSIVGSKSGSIVGSKSGNNSKDINNKDINKDISNKDISNNSNINTNNNTNTNNTTTDGFLCYNKIKVVQQIPVIYEVNRTRYCPFASNIIAIRSDHPEIHIYDYTKYLSMCGESSGSWVGGNSSRGSNNPYTNSSSNSNNPYTNSSRGSNNPYTNSNSNNPYTNSSRGSNNPYTNSNSNNPYTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT53</accession>
    <name>A0A4Q9LT53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1051p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001051">
        <property type="protein sequence ID" value="TBU11759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT53"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1051p0030"/>
    <dbReference type="OrthoDB" id="2190565at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="39286" checksum="A116F5BEB16F8560" modified="2019-07-31" version="1">MRVSILTWNINSKKSAFSDLKSIIENEMNADILFIGLQEVYFTFMSTSDLYNRVKDCVGSYNIIGFERLFGIVSFVLSKNNLQSESFRMGLGFLNNGYKGFTSHYIQFSDTNEKNNILFVNTHLIAHEKNLDSRMKQVSECFKAISSAYNIKEIDTIILSGDMNFRVSGIDREKVYDLIIEKNYEEILKNDQFNNFSKKYPRFKEGNINFQPSYKYIAGTDDFEVKKYRVPSYCDRILCNSKYKHNFTEYKSLENIRTSDHKPVLLRMEFEPIILDNSELLSDITDKNYIYKLYASEMFNFFHENIFLIGIMAGIVASGSYLHFKNKIKRFFEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT73</accession>
    <name>A0A4Q9LT73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1031p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001031">
        <property type="protein sequence ID" value="TBU11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1031p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11119" checksum="AB2FFF1D44EB84F7" modified="2019-07-31" version="1">MKLTGIKNKDKRQGLKYGETTIKDEEIKNKDKRQGLKYEETIEDEETIKDEETIKDEGTIQDEGTIQDEGTIQDEETIEDKITRIKTKIIKNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT83</accession>
    <name>A0A4Q9LT83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1461p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001461">
        <property type="protein sequence ID" value="TBU10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1461p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="6719" checksum="007556156E3493AD" modified="2019-07-31" version="1">MYSGIEGMIIGYKETNSNILLLNKPPLTISKTFKINNTPLTNNEIYKTNNTPLKPNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM7</accession>
    <name>A0A4Q9LTM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide phosphatase/kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0955p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000955">
        <property type="protein sequence ID" value="TBU11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0955p0010"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="40171" checksum="D9B964CEB1899794" modified="2019-07-31" version="1">MILDNLLIVKNYDKDFKKYVKIAAFDLDNTIINNLPNRAAEDERGWVFRYKNVISKMNNLHTEGYLVAILSNQSGLILAGTVSKFKRKIKRIMKNFNFPVIFIAALYKDFYRKPSIGMFNFLVEYHILDGNIDHKNSFYVGDAAGRSHLPFNDHSDCDIKFAYNANIEFYTPEEFFDEQPKSHKNIEFFKIDSYRNEISFDTKNFINFDIVFVYGNAVKYCGKTHFSKKYFQNFSILRNPQGISKTNEKIIFFDVYDENLIKKIIRNRKIQNIGVFHLSYDKKVLKYLKRLGELSGKKSESLIENCNENFSSFFDIPIISVPFIFDDTDFSPELRKISQLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU30</accession>
    <name>A0A4Q9LU30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1377p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001377">
        <property type="protein sequence ID" value="TBU11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU30"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1377p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="596" mass="70993" checksum="5E28982BE3396783" modified="2019-07-31" version="1">MYTAANNNEIEWENFHSIRREMVTNPFIYYVSVLCLHTFKKQVLIGKITEEELKLPYPAIYDIELNDAFFKMCDLINLLKSEKEILRLFVYLKTMEPFIWMFMHRLRILYTVFCFFREYLFEYSKKFNENLFFQKMFKRFVEQDLILNLVNYEGLFLEKRNLEIKMLEFDLNAYFEKESVFLNMKNGQVISEIGLYYELYGRIEQKETCNSDDLTSFAKPIYDTSSSLENKDITYTESNLEKNLSSSDSKIDQTPIKLNKKTDQNDLRLLKLSEIQSLYCNKIYKSDTKDVLKLDLEIFFQNLFCSKSHIELKNTEFSCYKNSELYKKHKEMCEKGTLEANEILFSLFYKLLLLKYEKQWKNILSSISTVPHKKFSNILAYLDKFTLSSDFQRDISKKTFFISIGSSAFPKMYLDEIVLVLDIDNTLFPTSYYEDKYPDFGTPGFYKSQNNIIADPNEENPKKGINYQEIKSKFFVTQHVEYRNELKKYLEKLPFKKICFTNAEKIHAEWALKTLDILDCFVCIVHREELYEDLFLKPYENAYFAIEQLLETKTSNIYFYDDIDQNVQAAKYRGWNSFLVGDSLIDVLEISLSNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE4</accession>
    <name>A0A4Q9LUE4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0140p0010</name>
        <name evidence="11" type="ORF">CWI38_0822p0020</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000822">
        <property type="protein sequence ID" value="TBU12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000140">
        <property type="protein sequence ID" value="TBU20052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0140p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0822p0020"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="315" mass="35224" checksum="11112FFFD9B0A13D" modified="2019-07-31" version="1">MIKKTGTTIIGLKYKEGIIIASDRRATSEYVVDKNCKKLHKISPSIYAAGCGTAADIENVVRMCEKEMSIFCKKYNMPGDIRMCVNILSQHLHSYGGQIGAGLIVCSYSSSSRDDGGRDTNNSSSNTSYLFNVHPHGSSSSHEYTSMGSGSLAAIGYLENQYRRGMSKEEGIDLAIKSIGLGVYNDLYSGSGVDVLVIGETVESIYVPLCKKEERDKIVYNRDSVVFIEEEVIFEREKLKLHLKLYNARKNELECVNDSSRCNILLYLDRNVFWGAEGVCQHCNASRETVDYLATRCKKMLDHDNTRRHNKECDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ4</accession>
    <name>A0A4Q9LUJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide phosphatase/kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0839p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000839">
        <property type="protein sequence ID" value="TBU12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0839p0010"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="40197" checksum="84D975D3DDE98AF8" modified="2019-07-31" version="1">MILDNLLIVKNYDKDFKKYVKIAAFDLDNTIINNLPNRAAEDERGWVFRYKNVISKMNNLHTEGYLVAILSNQSGLILAGTVSKFKRKIKRIMKNFNFPVIFIAALYKDFYRKPSIGMFNFLVEYHILDGNIDYKNSFYVGDAAGRSHLPFNDHSDCDIKFAYNANIEFYTPEEFFDEQPKSHKNIEFFKIDSYRNEISFDTKNFINFDIVFVYGNAVKYCGKTHFSKKYFQNFSILRNPQGISKTNEKIIFFDVYDENLIKKIIRNRKIQNIGVFHLSYDKKVLKYLKRLGELSGKKSESLIENCNENFSSFFDIPIISVPFIFDDTDFSPELRKISQLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ7</accession>
    <name>A0A4Q9LUJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1301p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001301">
        <property type="protein sequence ID" value="TBU11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1301p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="270" mass="31689" checksum="CB8FE303153714B4" modified="2019-07-31" version="1">MRISSFVLTSSLLLKHVYSLIHSIFLIKFINIRIMQPNFCLVFSFGNFIFTSNPPTELENMCENNRFFIKNYIRSAISFYFLYNYFYCCDNKKIETKRIESVKEKYINQQIRPELSLFNQQVETFDASGVKICKDMTCKELKNRFLTKFPNYDLMMFKKIFFGKADSLIPVLNELKNEIARFVLNEISNDDSIIVNCLVKFFTETEGIAPERLSSNSCKDDMNLGIVSSDYSGLLYKNLDKLISNNILKWYKSETFRTLFANIIFNFING</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN4</accession>
    <name>A0A4Q9LUN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0784p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000784">
        <property type="protein sequence ID" value="TBU12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0784p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020555468" evidence="2">
        <location>
            <begin position="24"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="711" mass="81801" checksum="2B0C68BBAFED57DE" modified="2019-07-31" version="1">MIISWLSLYLLFTYVMIVKPNESDSIQAPSSYIYTLYGNLNTDEGPNSGSGFTRTNSGGNGMDNSPVNGFNAHSFTNNYFPLDNPSVIGLWFGLNDAFETVAPVSMDQTNGTNDLADYTPNDSITFGNNGIEESEIMDQTNMDTNSTYQSTMFCGNGDSVALGSAAMEQNIIDEDRNSDMLVENQNHDNPLFLGSTVDEATKNGRQLYTTSLSDKDDLFFLDELDLVFISDAIESKIKDLGFFSFDFFMREIFSEGGDDVTESTDSQAILKAESIFHKDQSGNSLLFSSNLSTMENNTLKESGNSTAVKSYSREFKAKLSSFLENIPELKICSNYEKFLNMIPNLYKEIEDSVETNISIMEIWNVNDDDVLTFENYEDKIKKEIEKSKKIVLETDKFPEQISKFANKLIIFEKNNAKNINFPEQIQIISTIMEKIKNDKNLVIFYEILKFVYYYSQNLQNCIESGYILYVQFFLSVISERLDSFDNSFPTEYKICHRLENKCEPKFLNEFSKKIFVQKLFCKLLLGMKNGKMRSRFYNVYFSHEICARTHHNSSAFYNQSKIFKFYLRVFISIVLYPDFNSEIEYLEKFIDLSFDIFTTNKFCKKAFTQSLEHLITNTSIKSYSMIKTNLEIIKPLILITAKNNGEFIINSFSELENKLSKNEILSMKYVFESEVCLSWYLNKRYQKHAFGKAENYTSWSTIEKSLFESCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR0</accession>
    <name>A0A4Q9LUR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0948p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000948">
        <property type="protein sequence ID" value="TBU11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0948p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="297" mass="34972" checksum="25B5FE38769AD9ED" modified="2019-07-31" version="1" fragment="single">MFTSGKNNPNLNIKLVSILISILNFCILFDSSLAHKFTYSFKRNENFEILFFLEDTKEMNINTALDYKDSIKIFFDINYKFKNEKMHVYTYKKENFICFGLFDNFLSPNSSENAFKTGIIECNFELSYFLRICNDIIEIPSKWTNYDFKSFLQILTSFKAIENKRLLEYLQVIIFNNLMQRKNSVSNNRDFELKEVFGSCFFSKIDISIKKLFIIAYLNVLMIESAIKDGNLILMNSVNDYVDSYLFNEHIPYGNILVNDFKIFCALETVLENAYMCDIFHVLLSQINIKSLIFDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU4</accession>
    <name>A0A4Q9LUU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0198p0020</name>
        <name evidence="2" type="ORF">CWI38_0791p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000791">
        <property type="protein sequence ID" value="TBU12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000198">
        <property type="protein sequence ID" value="TBU19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0198p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0791p0020"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="88"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="33461" checksum="15F64B5E05D06818" modified="2019-07-31" version="1">MHTDNFNNDLVSETGTFNSCKSSCCTVHKRNTQNDSKITNKFFLKYGELTREERRCLNLYSYNVLKKLNSDSTVCKILGYFKNVFNKQKYEDFYSKKKINPFVYEIIEYLKMYGVNQKGIFRVPGNVVFYTSVPKLLEKGEKYDISLYDIHTNASILKAYIRIVLDGIIPLGICRTLVKAVKSCENSSLFLLVKEVFPFSLTDDYRKLLLEMYALFREIDNKKEINLMTMKNILTIFPPTLFPSDSLTNYEVVSAQHKFLELILELDFETVSLVRLMKAKKYCNIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV00</accession>
    <name>A0A4Q9LV00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0730p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000730">
        <property type="protein sequence ID" value="TBU12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0730p0020"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="31364" checksum="490ACBB9CD6FF446" modified="2019-07-31" version="1">MANFTQKEENSIPYWKLNANEKEFLYYYCLTKMEKINQQTRYKKIKCFLAKNLCCGKQQIKFPKSKRLEPIIFELIERIVNSEPTVAYLFFHREKLLDNDGIRLYIDTIKQYGVDIYQIEEIANLLISLIKVYDGLFHRELAYPLHKAMFMKPNGKNIEFFLYYMRFAFTEDERKLFTELRRMFIYLSNNNSSIYRSLLIENVDMYFPECSYFTKSNVNTQAKLIDYFNDFNFHSVPEELLKKANDKLHTMILKKSRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV60</accession>
    <name>A0A4Q9LV60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0746p0030</name>
        <name evidence="1" type="ORF">CWI38_0957p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000957">
        <property type="protein sequence ID" value="TBU11971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000746">
        <property type="protein sequence ID" value="TBU12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0746p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0957p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6430" checksum="12E0F4470C6381E6" modified="2019-07-31" version="1">MQQDKERKLYSKLYKAGNNKLACPHEEPVFCYIQDRNVFWGQKVSVNTAISLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR8</accession>
    <name>A0A4Q9LVR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitosis protein Dim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1072p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001072">
        <property type="protein sequence ID" value="TBU11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1072p0020"/>
    <dbReference type="OrthoDB" id="2188851at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="17332" checksum="11179C101FE02987" modified="2019-07-31" version="1">MENSILELKNSSEINQKIKNENKKLVVINFGHTDTFLYQHYNEIFKDLKFKLSLFVDFYNCQILNVRELIQNLDLYDDVNIMCFYRQKHIKMDFSTGNNTKINFYIKSKEELIDIFTLIFKEAVKGKNIVLIPTDHTYNKFSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA3</accession>
    <name>A0A4Q9LWA3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0181p0080</name>
        <name evidence="9" type="ORF">CWI38_0561p0060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000181">
        <property type="protein sequence ID" value="TBU04123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0181p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0060"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000054">
        <property type="entry name" value="Putative histone H1.5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU04123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="146" mass="16577" checksum="F363CAA1F7884CF6" modified="2019-07-31" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSTTVETPVTAAKRVHRFKPGAIALKEIRKYQKSTELLIRKLPFQRLVREIASKFKADIRFQYQSLVALQESLESFLTNMFEDAYRCVIHAKRVTLMSKDVKLVYKIKYAAAGLGLKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF3</accession>
    <name>A0A4Q9LWF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0542p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000542">
        <property type="protein sequence ID" value="TBU13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0542p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020677202" evidence="2">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="361" mass="41362" checksum="9E900ECA0B6BA9A0" modified="2019-07-31" version="1">MKIFLLLSIVSLQSISLLILYEKQVEKTADSLYRILLQILINKYNKILLSEGIRIKLVGVLSYSTYSKLSKYSDLSMYGGSNNISDRKTELDRICCDKSVVMAVSTEMDEDISNEVSLCRGRYFINLNSKSNSDTDMFSSLVNGVLGYLSGIFNVNAPNLLENESNGKFFKEKIHNKEWIQKIKRCYDSIKCEKDVFEEFERNIRGEELSESDSKDENEDEHVKKNEKSNSTDKDVGEKRKKRNSEENIPNPDKNENKSMLLEDKKGKNSKIESKTDKEIMLEQILSAVKDLSTVLLKKKAEHEREGNRNQSPFASPFSQRISRYTSEVDNKKNLTNNALPTNSDLTGVNYGIFRKIYKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL2</accession>
    <name>A0A4Q9LWL2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0546p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000546">
        <property type="protein sequence ID" value="TBU13054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0546p0010"/>
    <dbReference type="OrthoDB" id="2151624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="97744" checksum="4BD6F89A3B1524C1" modified="2019-07-31" version="1">MYFLLFLKSIHSSYKYYDRNINGVEYMRKSRSLKESWVGLLYVIGLGFLDIVNCASKSKNGNIIFGLLDLNWETGISKSELSKVKYWLSRSSESEQLGFCSGKHRFKCNNVSMPNLVCSLKISYRNHKPLRSFEVNYKEDWKVQFRVLNRFLLKDLDKPFLFNISMDVNCQEFEMFVKSVTFDPSFAVLNIGYDLFYRFLRLFDALDPISSINLSKFYSDLLRKCLMGISFINIMADPEHYMVRYFEDRNRSRSFMPFFSVISDSIDACFNPETSYLSLFKRTKHSTDQCFRYAINVSRLILKISISSLELLLSGFKANEWSVFNWLLSVTKISGFCIDDTEVTCSEMKIPGVCDILNPETTIRSAVPSKTISLGFFSFLADTNVKSIQYLKFVNVVPPFDYLDQNINKASVSYFEVAYSSIEECNRITALLQKMWEPNAFKLTGYKMNFDDINRILYSNIKILVLKECTLDVDTDWKPIRDRKGEFKLIGSLKQLNISSSIFPVCLVQLFLMSAKLENIYLNSLKFTACLSFDPFSNTKRNLDCLEADEYIPNECLNTFFTGEISVNSLYLRGTADFESVRFIFESVNLHKSVKYLNLSKNSLTVEHLNLIANFYCLKRLSLSRSLPSSMEGLIHSKIFENITHLDISHNDIFSQNSVYIIWFTNLKALDMSSVRIGCYILSSILSEKLKNSLSYLDISGVDLSLADFKCISECRNLRNLIFSYGNSCPLTTYSDVLKTAYVREKLSILRIETTGDIDIDDVLSLADFADLSGVKITCRTIINERKRELVVFNFKNPEFRIQFVLKIYFVDKFIEEIFNNLFKLCYCSFTYEKFLPCINFSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV0</accession>
    <name>A0A4Q9LWV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0496p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000496">
        <property type="protein sequence ID" value="TBU13228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0496p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020329393" evidence="1">
        <location>
            <begin position="20"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="665" mass="78401" checksum="45372190120DE749" modified="2019-07-31" version="1">MNIFFLINIINICFSNVEASLPRKKAKHERVEHIGAEHSERKSTVESARDCGFEEYNEFRRSNKRKELEDSIDDNLEQNGEENLTLSSQNTFFQINYLFPKNTESNPGVKASEVVSISDQAIKNVQSFPKTKLPPFRTAFPKKFHDYESAESIKTKCMTQSVSESQFPCLDIYTGSENLARENSHNYFFENKISCFNNAQEHSNDVVNQDSEPNEEIISNLDENNGPLQDDHAQGKHDMGIDFLKAQNSEQPYNDISAQDRDKAIEKFILKMANEVIIGLQNELSSIIREELGSKINKHDNSTDSDLMEPGILSDLQNKNSIFYRFEFKKNEDFKEIYKNRDRLVKFEYYTYFNLSPFDVMQKIKGYDLLSYSLELKKTGIHLIVSEIRYLLSIFELKNDYNIAKGHVLLVHYYYNIIKILANLIFGNNQEANKEKPEEKRYEAAALIQKRIFFMRKLLSELFILFQNDINKVKMYRILNMINFFSTVVGHKGSYFRKNHYILKMRFIFRFLFDPDLKPNNIFLAEIIHDIHSKNIIHCVEMYFKKKLTALFYDYYCINIYFDKVLAIIDSYKVYNDLLKFLKIEVGEIEKLKQKACIESMSGYTNARLISMLKIYIELECRVTYLERKIWSEDICVLFFFRYNSFEKVIKKVHENIDVHHKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV4</accession>
    <name>A0A4Q9LWV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-2 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0513p0060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0060"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="632" mass="72074" checksum="54D35276B83BFD54" modified="2019-07-31" version="1">MNYNCTGDIHFENILTKIKDKNILKSITGKLCANRMTAIMGSSGCGKTTLLKILSGRFNKKYDGCVYLDGVVADKKILCGVTAFVHQDDVLQTYSTVKESVKFACEIQGRRCDVDEHLSCLGLYKIKDQLIGTPMKGGISGGERKRLSIAMELIRDPQIIFLDEPTSGLDCLTASKLMGVLRDLSCKKTVVASIHQPSSDIFYSFDDLLVLKDGLVVYYGEVKNLVSFMENQGFPCPAYTNPADFLFTTFLPAFSVENNSEIPNNAQKTEKNVEIISVRQITEKIENKNFSKKIKFKSERREPLREFKMLFIREMVYLYRNKLLGIVKIAQSLFTVIIVGSIFYNIGGKDINTQIKNTCGVLYFLAINLFFTASFTSLQLFFVDYDNLVREYQSGYFCFSSYFEAKILANTLIAVSHPLVMVPLLWFLIKIEYSFVMYVFLMTASIFTSLVGQSVGILTASISSTLNIASAILPSAMLPLSLLNGMLVDPDNIFFIFKILQYISPTRHTFNILVKNSFDAGKIEDVNIKRLCTDFLSKMESIFMLFALYLINILLCNLSDFSRWLKKRKIGSNIGQFGYIQDRTTRCEKNFWHDYTRRHNELVRCINLFHIKSYKFNLKKRIKSHLVQFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ4</accession>
    <name>A0A4Q9LWZ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0601p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000601">
        <property type="protein sequence ID" value="TBU12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0601p0040"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="43070" checksum="8BBD6BA127F3655C" modified="2019-07-31" version="1">MAKVKSKLQNLKFNLTKCTKKVRNKYNNLFSLNNKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQHANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPRDEAVLCYIQDRNVFWGAEGMRQHCNQSMKTVDHLATRCEKMLGHDYTRRHNEVVQCIHLLLLNKYKFKPSKRIRSHSIRVDTRIKTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDFLQIVETEKLRKYDLLANELGLVYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLDMERASLSVILEAEMHKQPIPPLKQVDNEEDDEPITNTNEELKLEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA4</accession>
    <name>A0A4Q9LXA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0346p0050</name>
        <name evidence="3" type="ORF">CWI38_0415p0040</name>
        <name evidence="2" type="ORF">CWI38_0437p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000437">
        <property type="protein sequence ID" value="TBU13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000415">
        <property type="protein sequence ID" value="TBU13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000346">
        <property type="protein sequence ID" value="TBU13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0346p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0415p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0437p0020"/>
    <dbReference type="OrthoDB" id="2193718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="18754" checksum="3C7629251B72C5D5" modified="2019-07-31" version="1">MNTKEIGVVVLFVGVVFFIAGATFLLDKALMVAGNILLIVGILFLIKTKTIYIFSYEKIQGILLFLFGFFILFFKYVFIGFLFESVGIFYLFYDKIPTFKGILRGVVYRLFRMCLIRYMRDMKGFIDYSGIRGRDMSSEVLDYLSRLFMYVSWGIKIIECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ2</accession>
    <name>A0A4Q9LXJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0750p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000750">
        <property type="protein sequence ID" value="TBU12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0750p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="34175" checksum="E52C3AC2D2D0B424" modified="2019-07-31" version="1" fragment="single">MTNLNTDAILEGNRLIVLHSILDSVTVIEQEWPRSAILAVQKRFERMPRNDWPATLRYYNEKFGCALDIDADIRQEENRERCRIATCLTELCTLTDTTEYNNLRDKFFMVVRTRKLPSELVNSKLLDLNNRIIGDYADSLARIIQAAQVCYDEAKRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEMLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL1</accession>
    <name>A0A4Q9LXL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0406p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000406">
        <property type="protein sequence ID" value="TBU13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0406p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="353" mass="41933" checksum="A93D6B17EBC56CB3" modified="2019-07-31" version="1">MGIIFNTIFEKSKNDLMHGNYTKIISEKIEQYNSTAIENEETLNEILFFANNLIKFEEKCLQGLSSKEILSEQKITEIMKTIKDHKNLGVFYELLKFVNYYYENLDNYVEKNYALHIYFLLSIISRQLKFFDGFKTLQYKNCLFPKRKCVKNPSLVDYANKFFVQKLFSRVLIGMKDGVPRASFYIVYLSLDLPSYAHHNNYFSNHRSFFKFYLRVLISSVLHEEFKPQNTTLNELISLAFDLFIVKPECKTKFINILRGLTNVKSIGSSLIKRNMKLIKEYCQKTIRGVSIQEITPWLENEKYSVSFNDIFVSEMNLSWYLMQNYANNNFEADNEADRWKSIDRTFPRFYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL4</accession>
    <name>A0A4Q9LXL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0742p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000742">
        <property type="protein sequence ID" value="TBU12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0742p0010"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="361" mass="41374" checksum="E1E7351622BDC34F" modified="2019-07-31" version="1">MKIFNYSSKKANSVENFKKISKINHTNSTTIYKAQCKSTKKYFALKKLNKSLCLDNNGFSILYIREIKILNSIKHPNLLKIKEVTVGNNMCDIFIVSEILHTDLKSLLDKYNSYRNSVSINNLDSVISDSSYKSKFSNETDSILSDNMKNDTHLITENTNYDNTDLNLPIEVCKGVLIQILKGLDYLHSKKILHRDLKTSNILVSKSGKIKIGDFGLSRYYKEEMTNLIVTLWYRPPEILLGAQKYSYSVDIWSFGCIFGEIVSNSVLFKGESEVDQLYKIFNGLGFPNEGDFTDAPYFCNFICLPSYGKENIFKKFCKNEVEVISKLLIFNPCHRPQAKEVLADSYFQDVNDVGLIRNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY01</accession>
    <name>A0A4Q9LY01_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0697p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000697">
        <property type="protein sequence ID" value="TBU12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0697p0050"/>
    <dbReference type="OrthoDB" id="6493019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31705" checksum="680B149588B85DEC" modified="2019-07-31" version="1">MLGHDYTRRHNEVVRCIHFLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKILNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCNVEIIPYVITWDGIVTKYHKTYLKRLQIPINVETYIHSIVLKKTLEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEMKNEEDSVKQVNSKNTLPIILDDVTRPKDMTIDINDKSDVEKENKVVKVMEEICLTRENLLTQNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYD3</accession>
    <name>A0A4Q9LYD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0340p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000340">
        <property type="protein sequence ID" value="TBU13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0340p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="52612" checksum="8C866D33AFF0E6EC" modified="2019-07-31" version="1">MKYILIIILSNFCTKNPIKSKKYYINTVFDVIKKEIYKQYIEKSKRIDKICSYEYLFLESKKCFNMEASEEIYKFIFAKKVKKFQVMISLVQSNEMYNGFVFNISISIFGKRFIGFGFNDSFYRVRYKNICRKSYSNFTNTEIKEYFIKKHILRFIFWYINIIKKIIQKMILDRNKMSILTIFSDIVYFEDCDRDFLSRLLIRQNYTSDNDCSLLINFIKINDKYEETKNNKTFLEYSFTNIIFESIKNISFERVEFSDQLLEDKQNVTVYNKIVAKEIIKCGENTYLNIYDIFFSSFKNGLKMQNREIENLDVFGYSSANIDAITFIKVNTPGKSIKTNKANKSNKIIKIKKDFKEICCLIIRNREFNLEYNIDISYKVCNNEITDIFVNQRIPGFYAHHTLKDKIACILRFVKEHEIYNFKLVYWDLSKSKKIYAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL2</accession>
    <name>A0A4Q9LYL2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0292p0060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000292">
        <property type="protein sequence ID" value="TBU17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0292p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="3">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="55256" checksum="32D5E6C7C20F19CC" modified="2019-07-31" version="1" fragment="single">MEANDEAQKLKSHYEELIKAYKKIEKKLKTNNNQDNEYISGLYSEQQRLINSITMFNAKYINFMKPRKNSFGKFCDDLFRKKKLSNEISSFQAVQSKNMERKSETTPHTSEQNAPSESYDVFKNQNYTDDEVRTIDPRLLETQTPQDPSEDPLLNRKIFKSAKDSYIQMANQPQRIPPSNKTTYPYFPYPPMGYPYFSRSEDSLRMMPQDPRMFPPPMYGTSPSFTNPPGMNNNLVPPNYMNIPYGPNHMFTPQHPARMMQGPVPPYNNQAFSKQSPVYSSFYPQSTNQNLYENPRAITPNQNIVYPPVSPSKTPGSSQQYVQDTTLKKKRRLSVQSPLVREHEKAGFMFPHFSFTQPQIKADSNELQKLEEFIAKRKDVREVIKDVDSEIILDNGPAYLLYRIVDTFIEKLCSTACKFARNREDINVSCDDIKMGLYSEFGLELPTDCVIKEFKKPTDEHEKMVNAILKENRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS3</accession>
    <name>A0A4Q9LYS3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0294p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0040"/>
    <dbReference type="OrthoDB" id="2189962at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="553" mass="64289" checksum="C81593B8BEC2D7BB" modified="2019-07-31" version="1">MQEIELHLKYLLNSTTLTVTNIKPLMPSNSTTFSKKYLTTRRLRLYTQPVSSISNNIEVPILGVPIDFKQTTHKVFLAEIAVGNTLYVARDVGYAVQPPSHYDTFIVPSNRFDFNSEITDIKVLQDEDLINLSFSEKSSSFSRNSDSSILEKRTIGNSKNENLFSNLEKSSSSSNLEKRQIGNSKNIDLSVINDSLIKDQSFEENKNCKSFSYLLKDSSRILPLYEITFNYDHDLEMKSRNSSLCEMCQSFPSIMFCLAERASFCINCDKNIHCNEFTMRHKRYYYEKVGLSNFISCIYHPDSVVDYVCMKCCVPVCCICRMAGNHQGKEHELLEYLEACKILNQKIIQVVGKSEIDQNIENKNEEENENNYENKINSPRKNKNNFNYENNSSSKIQNSKLELFLNNCDLKMKILYEKYYKSLKSSFDVRKKLEEMYRKSLNEISGWEKKKFQILNAGYIEWNRLKDEGIRIKKYVDTLEKDGGRIVKEYLCLIQSVENVSKSECVVVSGNDNINVKGEFSVVIEEKENFYEERKEKLKKSTEMYVETRESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY3</accession>
    <name>A0A4Q9LYY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0260p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000260">
        <property type="protein sequence ID" value="TBU17977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0260p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="54" mass="6352" checksum="F5B44E76AF65F1EA" modified="2019-07-31" version="1">MADRRELLACKASRGSLIVSKITPPSFCYSFFFLSKQRIIIQNYYNLSRKNFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ21</accession>
    <name>A0A4Q9LZ21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0266p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000266">
        <property type="protein sequence ID" value="TBU17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0266p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="479" mass="55311" checksum="BE985B0127E99D96" modified="2019-07-31" version="1">MGMVFTRKNKIIFGIGVFICSIALVIVSLSLFLGIKMKRKLLNEFNEFTASSQCKRLRKWVNTNNNIGIIHIKEQNAIDISVCFSYQHFDDLFKCCKIFLDKNKEKQKKILESVNVNDLVAKLYNIVMFPYLFSIDRLKKFWKCYDPSILTKLGIFLSGGLSEFNFINKTISLLEGFTKNGEGSYETFEMKKNSVKVSMSYCSDSAKKVEEISFKSKKESMDFMIFLLGKANIFDKKNIIDTINFISCNSFGKNEVLEIIKNVSDTLARPNIAQLITKYISDSENFKKMLKDFFETVKDQEIDVKKISKEFEGIIWILIDKIIDAVLNQSGSIIKYLDDAIDNLKDIDKILNHPFILNLPSAFLNRIKIFMIETEKKTTSELLNLIKEFLKACKKKYILIKSEGNKASSNFKMIFDLFKSQLLEKFLENEEYIKYIINVVLMFDDTTPSDDENIAKIHTKLLGDLCLSGVRMILTILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ8</accession>
    <name>A0A4Q9LZJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XPGI-like DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0456p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000456">
        <property type="protein sequence ID" value="TBU13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0456p0010"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="22070" checksum="AB57B0D5E43A480A" modified="2019-07-31" version="1" fragment="single">MGVKNLWKILKKCAEEEINFDDKKLAIDISIWMYQYSSLPHNQSLYFITKRILKLIYYKIKPVFVFDGNIPDLKRKVCEERRNLRNYVDLSDLARKFIEKKICKICCKKYNECVHASVEKDNLFSKIYKNCIDRLENHEYDWGDDISSVSEYEDNIFFDNNEYNTYDCVTDNQFTDTEKSIINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZM1</accession>
    <name>A0A4Q9LZM1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0207p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000207">
        <property type="protein sequence ID" value="TBU19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0207p0040"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="28696" checksum="3EB0DA8C67C891F4" modified="2019-07-31" version="1">MKRPYQEETVIEDKSTRTVLITNLENAEQIKPFYKDLPVKEVYTIKENQNILFIIFYDLRNAELFFQRCSTLPFPAVPIYTVSKYEIPRESDKCDEGKNQSTILITNKDNNTLSEEEVSKMCSIFGEIKAVREYRHNQKFVEFYDSRSALEAFKKINEKNSNNNLNLRFVWDNSVKARWDYINNTDRVLKSFQENKYKNEIVKRKKLSKEEEITKKKNFYIGLFDDFIIQNINEIEKMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT4</accession>
    <name>A0A4Q9LZT4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0128p0020</name>
        <name evidence="13" type="ORF">CWI38_0292p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000128">
        <property type="protein sequence ID" value="TBU04499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000292">
        <property type="protein sequence ID" value="TBU17003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0128p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0292p0030"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU04499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU17003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="528" mass="59084" checksum="5111C4EF7ABCFF61" modified="2019-07-31" version="1">MQQQPMKYFVLVKESPIQIQKNNANAAAAVATLVKTCLGPRAMQKMILTKIGSIEVTNDGNAILRELDVSNPAAKIIIELARTQDDEVGDGTTSVIILTSEILGQMIPILENNVHPVVVSNFLSKLLIFCQNHLKKISYDVENKNEEKLKIIRSSINTKICSMFGVKIEELALKAVQIVGIEEMGMKRCDIKKYVRIEKIAGGDFSECRVVDGLILNKNIVHSQMRRRIENPRIIILDFPLEYKKGESQTNFEFRNEEDFTRALEIEEEQVKIVVENILKFKPDIVVTEKGICDYALSILYSNNVTALRRLKKTESERLSSISGASIISSSDDIQEKHVGIDCGLFEYEKIGDEYYCNFLESRKQKACSVILRGSSKDILNELERNFNDAIKVAKNIFFSPKLVTGAGSTEISLAKLLESSNFYLNGTETEKKITLGLAEAFRNIPAILAANSGVHSPLSVVSKLEKKHDENHYYGIDGITGDVVDMRGKIVEPLVVKLQYIKSAIETAILLMRVDGIIYSSKAQQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K8</accession>
    <name>A0A4Q9M0K8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'5'-cyclic nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0119p0070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0K8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0070"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="490" mass="59314" checksum="69C78311F9E240A7" modified="2019-07-31" version="1">MNTYELFRSRIYQVLDTKNIVYQKSDIDLEINDDDIYEFKRYLNIWNISYLKCKLFKKNKLIIYIFDSMNILKYLKITNKDLSVFINTVFYYYGPNAYHNEDHIIDVFISSYYLLKKIDNINQKTALIILVSALLHDIGHLGLSTKYLSSQKYFTDKFDRSSLCERIHCFISNLILNTYECNILRNLKIEERNEINFYIQQLILSTDILEQEKYINMFICHHHDFFFSRLDKNCKKDNECLKTEIIISKNSKNLNCLNYSNQRIGIQPIELYLKSNSKKRNLESEKLLAKTHTKRDGHYKKRRYYYKKICQVCKLKQKNFEIPIFTIYLNVIKEIKKYFKLQHEIRKTARKFVIEKLNAYICNKSKILKHFEIYNLFLKKNIKNFEKFSIFDMFMIIKIADISATMKDTGSCLYCLKMLLQELKHEAFLTNNLDKLSFKCSDEMFFFDNYVFPVCKMMGFYDEKFEFLYKNANKCYFYFKNNMLNHYFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R7</accession>
    <name>A0A4Q9M0R7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0110p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0030"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="7">
        <location>
            <begin position="537"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="703" mass="81932" checksum="ACB7A337866F5B8F" modified="2019-07-31" version="1">MINIFILIVLLAVCIITGALFYASNEQTKLLLFIPFNISVAGLSTLILEMTKKTKLTIFLKTLLRLTKLVVIWNFILTLNKLINIESLFTWLCFGVFYIVTDLVRAYIYEYVEKCFFDKIFDGTMKEIFQVERYFLYSDGVLSRKRLEDYKDDVDLFIKRDVRKFTNLKKLFIMWSGQLHYSVYGDGGDVNNYNEVNELFNECTTNESLDESLNSSENYNLAQEIFEETAYETVGQAVIDEGNQNQGEETANETVGKSVIDEGKQNQGDEAFEEPVNEAVVESALDEGKQNQTEESFEETANKAVVEPIINAEDKNQNETENSRKRDRCNGNGSLSEKISSDTNDSNYLSDTGLDYLKCDGYENFVFPLRSELKGKKNRCQNKYYKKRDANKIDTRASIYAPIIEDSIESKDKESKEDPFKNLFISIESLATNFEYSIAKKIFNLISFNSTNKIDYESFKIHMGQIENERFNLYNSLKDFDKLHLKFYLTLFFFHTMIFCTVLAIYNEIRFSLLTLSIPIFLFCLFPSIKRICESFFFIVFTHPYDSGDKVNFGDENMIVRKINLLSTTFEKWNGEKVYVSNQVINKFTVRNIRRSKPQFWNLQLGISINTDPNKIDILRERLEEYCKMNQAFNSATVNCDSIENVNMLILRIIIKHTSNFQNGYFMWTNHTNFMYKLKSILEELDVHYIEVTKSVYLFQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S0</accession>
    <name>A0A4Q9M0S0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0234p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000234">
        <property type="protein sequence ID" value="TBU18632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0S0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0234p0030"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="395" mass="46983" checksum="2859D0C1A603DAF8" modified="2019-07-31" version="1">MHNDEEKKKLYSQFKATLCTDDSLIKTRESNYIWRIWGLSDFNHERFLSVTNLSTDYLNLLDRCDLIFGYSNICGANKGFRKERIIENTNLNKDFDEFFLRNIKQKNENKPKDDRFEYKRTFMSKIPKNKNIFKSNKKNLTKADERSLLNRKKQYESVTAHESFYRYPSSIQEPEKSDPEFSSPANKYTGPKNYTRIHVGDDYPYGKDRYCRENYDPYVCNYKDQQFSEMNQERLRTHRDMESGYLYNNTEPGYELYKPDSRFGANIDKEEQPFNLNDACTEFNKNYSSWSQLYSAMNNIANTSRQGSDYSVQHRSFPQKMYYTPTDVSYQHGNIPICANCQTKETSLWRRLNGEVVCNACGLYFKMHGVRRPITLKTNFIKKRRRISKRNSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W5</accession>
    <name>A0A4Q9M0W5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0368p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000368">
        <property type="protein sequence ID" value="TBU13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0368p0050"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="89459" checksum="A3DBB72A8B7BEE53" modified="2019-07-31" version="1">MNNFEDLKLYFMFNMLYYLILFQFIIANNFTYSFERNGNLEILFFRINKEESAFNTLAPNFCDLYISFHESFESNHEKTRILNDFITSSKSLHKYERGIIQCNFELSYILRLSKDIAEIPCVLNNYQFSCILAVLKRLKAVENKRLFEFIKFLIITDFFLYNNCLNIQEIFDWALSLEINVQSSNIILSIIFNFLMLAHVFYDGNLIILENTSEIYDLKVFDTQVLYKSLLVNNIKVFYSLENALKNPQILETFKSMFSMLNIRSIVLYNNQRSKILESDFEFPMFKIDGIKSITIIDFREFSSSLFLKRLRKHIRKDLEVLKFQNTYIDISTLTTILKDQRFKKLVLNNGGIPVFFHLSNNFTGLNQSLKCIDFRNVTVDLDWWKKFFMEANVDKIIIHFSIQFAQDAFIMAFGFVPFPSSNNVTYFKVIFDNPQIPTSFFGSLSCLKNLRTLKISKYLVSEAIHSRLFEVIENFKVLKCLVLRKYGYSKKYYISLFKNPAIENLHLESIFQDSEIFIVDFLNYYSSLTKLVLINIMICQSSFIEIFELKKLTSLTYRSCIVEPKINSEPFCLKSKNISLLTINSNNLNDFKNIDLLSNLETIENLNLSLCNLPSGYLSKLSLLCNLSLKILSYEFNSLNLNDLQRMGKLETLEELNLRGCKFIRINFCKLNCECKFLYSLKKLDIWLVRINNEDLKFICNFRNLRNLTLTLSGLDLYALEDCLILLKIYQFSTHVNIADRGFIKLFGCLNEKGIRVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M136</accession>
    <name>A0A4Q9M136_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit 1 of origin recognition complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0078p0060</name>
        <name evidence="3" type="ORF">CWI38_1838p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001838">
        <property type="protein sequence ID" value="TBU10339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000078">
        <property type="protein sequence ID" value="TBU20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M136"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M136"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0078p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1838p0010"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17979" checksum="184D9EF168C768FF" modified="2019-07-31" version="1" fragment="single">MSVVSREEEYNILKDYITDFIKSGIGKSIYVSGVPGSGKTYTVTKLLKNIKQKNVFEYLYINCGHLKTKNSIYLNILRNTSCMKLNQKQGFLKTLQTHFLSCKKHHIMVLDEIDLLITPKQELLYNIFDLPYIESKNMSSKLLIIVIANTLNLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N3</accession>
    <name>A0A4Q9M1N3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="20284" checksum="65E32527A00C8628" modified="2019-07-31" version="1">MSHCESDSEESPTKNTSENSKECIFNNEFKNILNNLFETYSIYIQAIIDLQSGNYHEPRYISKNELIEILISIAEFKLLCFKELHFLEPITMYELNFCVNLNCKNQCSSQDLQSIYNVFNERELMYTEMLFRFNKIAIEMNKCELCEFLNRTISENLEFQSVNVKKLKEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P9</accession>
    <name>A0A4Q9M1P9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0353p0020</name>
        <name evidence="3" type="ORF">CWI38_0040p0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000353">
        <property type="protein sequence ID" value="TBU03118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0353p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="788" mass="93079" checksum="95D1372C4E7F3C30" modified="2019-07-31" version="1">MKIIYRNIFLIYIILILNKSLLSSILCKKVVLYSIETYNNDIKYNETNENSWYEFKLENCNLLKMFSSVYLLENGYLKCCLRSGELKYFVPKKLEISESRNIILDFAYIGDDQENSLAHKFFLGQVSVIFLQRFARYITISDICVTTIYLREFINILRVLEILGLKRTKNNNLFLTYVLINSFMKDTFNFKCLKLFLNFKEFDFKLSDSISEYLFGIFSKLLLLENNPNHVFLLCKSNESMQVQKIILSYSVYNYRKEKLCKQNFFIVSNDTVMWLEKILKLAGSIDCVCFFIQTCKIDSLHFNLFYNKLSINILNLLWQLKLEKLKNLTLVDRFDEKIILKLFMNYGYFNISECITIISNLNSKEIDLILTHCKSIKKLAIVSDEAHYDIILELHRFASNNPNIFIKYKCKNFVMNCNQNDFFADTPENFSFIVGKYNVTLRNCDSCYKTSLIFFRRIMICLEKNKSLNGCKFIYYKASNVKDIWICTKQNNLQLKIHSKLIEYLADLPALEAIFFENILFTKKVIRFVLQSKKIMSLKLRNVQISSEVFSKYKIYNYVLQGLTIKKSDFIFNIDFLRFLSMFKNLSFLKVYIQYIDTYLRKKIYQFVSKKANNKFILIVSALDYLKVTTCKSIIGEFPILFSLSKIFDLKKLRVLIIEIVDFSAEDLEVILKLTNLTDIQINIYRKTMDIDFDKLIICIKNNKIEKFWFTVVELNKNIIKFLYLLKDIKLGITIAFNKIQIEDFTSPITIAFVNQSVVSFNVNNSFVIKEKLNYFKEKGISISTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T4</accession>
    <name>A0A4Q9M1T4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate transport-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0043p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0050"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="224" mass="26105" checksum="86A6EA8019C32230" modified="2019-07-31" version="1">MKPIRGYIHNFNEANLVMHAIRLGLVEPVRDRLCIEERELIRSGCIFCFIETKEGMKRWTDGKIWSPSKIVGHFLLYKQVPRHLSKSSLKKGIHNGSNYMKNGCSLAQSINDKDESEKLTFFKKTISIPFDKKTYHIISYYQPLFAKHGISDIPFFKDLSRSLNDFPILNDEKYLQSLKEKNLNIANEFNLTKPAENNMHPMVDRDELEKLAAGILVKRLRLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V5</accession>
    <name>A0A4Q9M1V5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0251p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000251">
        <property type="protein sequence ID" value="TBU18153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0251p0020"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="24759" checksum="A17FF77C335A4855" modified="2019-07-31" version="1">MGRRPGRCYRYCKNKPYIKSRYCRGVPDSKIMIFDLGRRAAPVLDFPASIHLLSREREQISSEALEAARIAANKYMAKHAGKDNFHLRINIHPYHVIRINKMLSCAGADRLQTGMRGSFGKPYGRVARVDFGQPLISIRTKENLKNHAFVALKRAMHKFPGKHEIKESCKFGFTEIKKEEFEKLKDEGKLISKGLHVSIIRDKGSLEEFSSNLAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X2</accession>
    <name>A0A4Q9M1X2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0038p0050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000038">
        <property type="protein sequence ID" value="TBU20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1X2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0038p0050"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="272"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="672" mass="77193" checksum="84BCF67AD76D29CB" modified="2019-07-31" version="1">MSKDIEITFDSKTYIYPPGVTPFKISKEHNSEHPKVLVAQSEEKLLPLSTPLFQNTKIKFLTFDDAEGKKVFYHSSAHVLGYAILQIYPNAKLSAGPPTAQGFYYDVLLDKNHTFSTNDYLQIDNKMKEIISKKTPIEQKFFKREDLLEKYKENIFKKHFIDEAIKKCKEDELLSAYCINDFVDLCPGPHILFTNNIKLIKVTNHGSAYFLKTKISLTRIHGVSFPSLQHFDEYNRNIVKAKKRDHRNSDLFFVSRFSPGSPFFTVSGTFTYNSLLNYIREEYKKRGYGEIITPVIYSNELWETSGHLQNYKENMFLLSVNGGDSVSKEVDEANNCGELNGQSDGSNCHNNYALKPMNCPAHCLYFRQTDRSYRDLPLRLADFGVLHRNELSGTLTGLTRVRKFSQDDSHIFCMLQQVEGEIRGVLDFLDCVYSILKFSYDLKLSTRPEKFIGNISDWDEAENMLIRALEGRDYTINEGDGAFYGPKIDIVLYDGYGRQHQCATIQLDFQLPIRFNLKYRSKEGKMESPVMIHRAILGSVERMMAVLIEHFDKLPFWLNYRQICIISVVKSENVNNMQSESSSSKILSYCDSIKENLSEFHVFVDDSDLSVSKKVLRAETSHYSVICIVGDKEVQEASVNIRGHGMVKLEKLKEILTVMLKRKIELNDAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X6</accession>
    <name>A0A4Q9M1X6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0028p0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020876313" evidence="1">
        <location>
            <begin position="29"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="30259" checksum="2C09E72078F1EB57" modified="2019-07-31" version="1" fragment="single">MKFDFCSFYMNLFHKLLFLSILIFIKHSSERNVRFNIPYNYEESCSNILLKETKLKCWCQIQRSSIFDTNEVEYFENFTRKDKNVQYDEYVISDVEKLNLKFDTFYKFNNINSNLNMGIRKYVGSEKQEEKIIKAANRASEVDEVIRECKNDQGIPQPSSYTPSTIINNISIPPSEANTNTKVCLLNTIPSPYNPMHSSTVTPRPDIAASWPNLCTIPISERLVVLRSILRSIEAERQEFIRCVLFAVQTRFDRMPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M271</accession>
    <name>A0A4Q9M271_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0226p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000226">
        <property type="protein sequence ID" value="TBU18871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M271"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0226p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="36673" checksum="559EFAD030536025" modified="2019-07-31" version="1">MLLQLSDSAILKDENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIGPRNEAVFCYIQDRNVFWGADGVCQHCGKSEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRNYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNLEAYIQSIVLKKTIETISFDRRRGLLSGLNAEESWERASMSVIMRSEMHEEPIPPLKEAKTEEDAPLISQGGTTLKEPTNNINKESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H5</accession>
    <name>A0A4Q9M2H5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0011p0060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0060"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SULU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020614003" evidence="5">
        <location>
            <begin position="17"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="51514" checksum="51C4D443B57108B3" modified="2019-07-31" version="1">MIWYFCLIEVILSSVSQEIYKNTLYLEANQAVDIDMEGLNMKKTFVAIQKIGKGSYSDVFKCRDLSDGNFYALKFSSIQDSMYLKNEAYFYQQNPSEYIIKYYGFGRTTINNKMYVAIVLELGLFTVHDFIMNKDLSRVQIQIIIKQVLDGLNFLHYNNYVYNDLKLNNLVFTDRVTIKFLDFGLCSYNFGPLKIFSSNISEKEKMKFAYIAPEVRDRSYYNKKADIWSLGALIWSIHTKENFEGSVASLQLDLETKHFLSFLLQENYSIRPTIDLLFFNNYLDEMFTCLDDFSDIGDFDFELENFLKICKKNNVIMFKTEEFSFFVIRLDLNDTYQHTALRKMVLHYTLKNMEFCNIFAPNFNYSKYIGFVIGFNLSQLHCVTQLDFKSLCVLESLMHLVKNIELIQKEDFDREMIDFEYLKNLLEFLDCRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M316</accession>
    <name>A0A4Q9M316_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0165p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000165">
        <property type="protein sequence ID" value="TBU19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M316"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0165p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020679057" evidence="1">
        <location>
            <begin position="22"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="763" mass="90631" checksum="77824485D203FF60" modified="2019-07-31" version="1">MCFRLLEAINLGILLINLTNLHICTLSVNFIAINDDEKPNITINNIGVYFLDMKKCLLLEISDMPKSLLSLNCINTNKRHLIVYPNDTFLEFKFLKQNIIKKYKKITIYMSKNDFTIISYFWKLLKAEDSIVSLDANVFFEILKYLNIFNVKRNKKYKSFINSLVIFTVMKNQKRFLEKSAEFMLNSREYNSFNILDIIESIFKFYLIKKLFVHVTFHEYIPISFLKTRYTNKKLKKPKNCVSMQFENFYFLSYFYRCLLLDPILCNIWILITKILYIDKLYIDFSILNEDIDIEVVFGSLAQNINKFSMVVLEKNLPILDKLKKYGHLDFIKNLKLYLFHSSIFILKTLPYFNSLEKLTLEFSEIKIYEICNLENLSVLENIKYIKIILCKPIDIQSKISSHLLLGCKKNLFVDLSGTLNLSDSGNSLRNFLTFNFKNYIIGIALKPNFSNLDNFNLTKILHYNLITRLRLNLENIEAKLLENYSFLKYFKLLSKLHFIYIMLTNDLLRILLKLDNLKYILFECFQISEPIESENLNYTNKCVIYIEFNTLFGSLDNNFLCFIARFIGLKHLSFDMVTISYSPVEIFVYNEIENLSVVSKYKRLENRPKLEFLQYSNEIKYVSEIHFSVLYLFSLFFDLQNLKELIYKSYYLNIKDVTVFENFKKLTCLELSIKENDIYLYILQKILESRIKKTIFKLDILVNKFNKLDLIAILYFKKLKILKLGAKISDENDKQNFKFLCRMNTILSEIFVSTDIQEVYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3B1</accession>
    <name>A0A4Q9M3B1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0034p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3B1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0030"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="106684" checksum="545754E8A22956F7" modified="2019-07-31" version="1">MSKIIYCRIPNEAKRSMELKVANNEYFRPKLLPIYIRIAFLLTFVVKCNKCIKVTVQFKNESDVDTFTEYVDFECGHIPGITNEPSNEIVPMLQPQPHASYSLGRESWNRRSYEQIHYHEHTMSERDFGRFLRGEIRNLGEFEDVSSEGFDEQNLGNRLRRTFPADAQAIVPFGEESSRNSQRNPLTSSSIDFRGYNPGENRYTTDYDSQNTVVVRMGHNVVRHKIPAISFEYSSVSIIRLGFFDQLIDSGETEISLDVEDIIKEIVDRNMFCLFLRTCFNGLDPKIMGLKKENVLNFVGLIQDFRCYSSSSALNKLYVYLLPFLLEQKNAISKFSTIGMSDTDIIRYNKLFIPFLNTIFETIDISFDSLTEELILLKTNTPNKSKSLDFSYQKEIKFRISIEALCILNDNDFKYRTETFFWLIRMYRIKGIKISANDIYFDEIKDSDKACESLLRHNLQPDFEHQTNVLFNIFIMNSLHLYVKNLELDKVSLSVMDVDYLKEFVNLQSLSLVKCILPSSSRLLDGITKFFFRLKQLKIVCFPLSDNFFRGIKNSLIEALDLSCCEYVDIDEWFDLKGPLCNLKELKLDSLKLNDQIFSFFLKSKYLKILSARNVNFREFKDLENFDGFQRIFDFLDISGCNFSESYLNFFSTNLRVRTLIMQNAKDDEAEHRILSSKTLYQSVETLDLRGNILTPDMLASIKKFCSVNNFNLSGSLTDLLDDANDFYTFEDCLKTLNISCNRLKKSFLCFLNRFKNLEEFIAADCNFDSGFMSYLESVKPLNKSLKKIDITGNRVDIFDIIGLRVFENLESIAITLNSKVISDYLEIHVSPFCANLKVLTLASVYVDEIIFKLIMLHSNIVNLKFVNCKIKVNSFPRELRKELRLLNSVTLFETNVSSTDLTTLEYFRRNGIGVSLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3B5</accession>
    <name>A0A4Q9M3B5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0154p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000154">
        <property type="protein sequence ID" value="TBU20006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3B5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3B5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0154p0020"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="596" mass="71023" checksum="AA3D627446C7DC34" modified="2019-07-31" version="1">MYTATNNNEIEWENFHSIRREMVTNPFIYYVSVLCLHTFKKQVLIGKITEEELKLPYPAIYDIELNDAFFKMCDLINLLKSEKEILRLFVYLKTMEPFIWMFMHRLRILYTVFCFFREYLFEYSKKFNENLFFQKMFKRFVEQDLILNLVNYEGLFLEKRNLEIKMLEFDLNAYFEKESVFLNMKNGQVISEIGLYYELYGRIEQKETCNSDDLTSFAKPIYDTSSSLENKDITYTESNLEKNLSSSDSKIDQTPIKLNKKTDQNDLRLLKLSEIQSLYCNKIYKSDTKDVLKLDLEIFFQNLFCSKSHIELKNTEFSCYKNSELYKKHKEMCEKGTLEANEILFSLFYKLLLLKYEKQWKNILSSISTVPHKKFSNILAYLDKFTLSSDFQRDISKKTFFISIGSSAFPKMYLDEIVLVLDIDNTLFPTSYYEDKYPDFGTPGFYKSQNNIIADPNEENPKKGINYQEIKSKFFVTQHVEYRNELKKYLEKLPFKKICFTNAEKIHAEWALKTLDILDCFVCIVHREELYEDLFLKPYENAYFAIEQLLETKTSNIYFYDDIDQNVQAAKYRGWNSFLVGDSLIDVLEISLSNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3G8</accession>
    <name>A0A4Q9M3G8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0013p0010</name>
        <name evidence="3" type="ORF">CWI38_0104p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000013">
        <property type="protein sequence ID" value="TBU05425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000104">
        <property type="protein sequence ID" value="TBU20252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3G8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0013p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0104p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="241" mass="28563" checksum="F02E805E5CE4D1C4" modified="2019-07-31" version="1">MIINSIIEYGIFSIFILFYSCLICMFDIFYGSLLYIFYKEELDLFIIQYLIIMYMIKVLMSIYYFSPDNTLIAKTRFLIYINSFSTGLFAGIFLKLKFKISENFGGLDYVDSFIYSLLHVIISYLYTCAITFYDVDFNGKSLQYLKYCGFASIYFLYPFLSYYVFIQFLSPVFVCFLCIINYVLLTYQLNPRSTKEGKTDNSDLDTYFYFVWAIFGCYTFLVTVFTSIKWLGGIFENMNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H3</accession>
    <name>A0A4Q9M3H3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0100p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000100">
        <property type="protein sequence ID" value="TBU20262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3H3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0100p0010"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="258"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="42482" checksum="0804118F7B9D3745" modified="2019-07-31" version="1">MARGRPVKKQESSESEQSNDTSCSSSEQSSASVSASGSVSEQEVVSTKKGVQAASCSESGSSESCSASGCESGSSATETDSEDSGDSDSDSSTATESVETKSELPKGGKPAVCEKIEVESNESSTEKSEKDSEEENSKSASDVSSEDEKLSSSEKSEKNDEILSEEEKNRRTIFIKGLSESANESSLRKELQKNGKVVDIRIPKDSRSGKNKGYAYIQFSKESEATSALKLNGKKLLGTEVVVDNAKMKNRNEGGDGNTLFVRGIPFECSEDKLNKYMSKFGEVLSVSIPKDRENINRNKGFCFVSFKEASVAEKVVKSNLVFEDRKLSCEKKMGENKFGNKNNNSGFRDKKRENMRNTGGNGFKNNRRDSKGFDNKNKRVRFRDNDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M424</accession>
    <name>A0A4Q9M424_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0084p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M424"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="637" mass="77001" checksum="24081AEF301DBEF1" modified="2019-07-31" version="1">MFLDKKITEHIDFLRIFDAENSNKNKIFDTFLEKSSDVTKLRDSVINSEILENYVFYFLQIIFIEEKFNSLEIHESFYWKDIITGEFYKSKSFIYEKLNISLKIIFILNKYLERNEESEQSEKFSYFYKLIFYFLETILKLIQQKNNILPTKIFQVSSKQLDISLEFLTALKSYFQYKYTLFSKINNMDSEEELDRCNLSYKLCHFLSKLISDLKSLHNLYKNLFCTDFQKICKNLLFKCKEDLDYYSLNLNYYKALCYYKKDDIKLAFDTLKMAVNKISEIQNQKYVVLEKFKTIIEKINDLFKDLTIQNTLTISYNTTNEIFLNIETYESSYENIFEIFLYKDIYYDFIPVKIEKIIETYLKEEFILHDDLIASTKLYKNQINKLKKKNYWILYSENYKIYFENLNILLKKENIVLEENKNSIKIGLSNINTNFLNATKKYKNYIEMNIKKYTNYDFIDEKYNNLQNIYLECQKVKDILLKVKHIKTYTVSTFNSIDNFQKLQSNEILKDIINLENQITDLETNMIKSNKPDVVKYYHESIIYSNNPIKFEDKLNLNKKKMYENQISLEMIKERYKYVSDEIIKTIFFLKSKNIIDYHNTIKKTSKNLKKKIKMTDFVIKNINRLQKLITDFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4D4</accession>
    <name>A0A4Q9M4D4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0076p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4D4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6039" checksum="5CF43D85BEF51BDB" modified="2019-07-31" version="1">MTWDGILTKYHKINIPIKTGYRDEDGELTININKESNLEEETMTVKEIEGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M607</accession>
    <name>A0A4Q9M607_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5100 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0080p0020</name>
        <name evidence="2" type="ORF">CWI38_0001p0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000080">
        <property type="protein sequence ID" value="TBU04848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M607"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0080p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0120"/>
    <dbReference type="OrthoDB" id="2189011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031495">
        <property type="entry name" value="DUF5100"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17029">
        <property type="entry name" value="DUF5100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="125" mass="14834" checksum="349E70CEA03A2734" modified="2019-07-31" version="1">MNIENIYSKLIGILNIKHEQHNEICDILTATDTYTQTKISNVEKFLCPTEANFQLPNVFLRTKKIAECEQLVGDRTHVDIEKWNECLNELEKICEFEFEEPEFIESSENDLYDEEFIERNIKQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVN1</accession>
    <name>A0A4V2JVN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0098p0020</name>
        <name evidence="3" type="ORF">CWI38_0004p0040</name>
        <name evidence="2" type="ORF">CWI38_0006p0090</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000098">
        <property type="protein sequence ID" value="TBU04702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0098p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="105" mass="12439" checksum="3A824169E2D359D4" modified="2019-07-31" version="1">MYREILQMFKKSKKTTLFSQFNSKMINNKGICFTHINEEDCNCRSTEYLGRVIGIAEFFENLRNSQVKTGYEIIEKGKDITYVLDPNVRKLAKFFEEKLRSFCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWL2</accession>
    <name>A0A4V2JWL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2277p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002277">
        <property type="protein sequence ID" value="TBU08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2277p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="62" mass="7114" checksum="EB440CF26140CE85" modified="2019-07-31" version="1">MSTEGAVNKILISAPERKTRREKDSVIHLKTKNYTLISNEGHTLDEPTININEESYLEEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWU2</accession>
    <name>A0A4V2JWU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histidine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_2166p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002166">
        <property type="protein sequence ID" value="TBU09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWU2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2166p0010"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="441" mass="50267" checksum="93AF4185803F7C5E" modified="2019-07-31" version="1">MLELRTPKGTIDYSPRETMLISKIIDKSISIFKKHGAVCIDTPTFELKEILTNKYGEDSKLIFDLADQGGDICSLRYDLTVPFARYLASNKIAKIKRYQIGKVFRRDNPVVTKGRLREFTQCDFDIAGNYLEMTADAEIIKICVECLSSFDLGQFCISINHRKMLSAIFKIASIPSDLHLTVCSSIDKIDKIQWEAVKLELISKGIDDSQAEIIKKYISKTGSNDLLNELKNDTIYGLEEGKEAIDDLLLLMKYLKIYKIENIVQINLSLARGLDYYTGIIFEASFKQEEVGAVIGGGRYDNLVDGILKSANRKDFTVPCVGFSVGITRIYTLMQKKYKNIKDNDTLVLVVSSGDQFLENKMEILNELWDNNIPAESVFTKRNDFLAQLKYCEQKNIKFCLIIGQDEINSNSVKIKNILKDENFEYIQRDDLVGFIEKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF5</accession>
    <name>A0A4V2JXF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1117p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001117">
        <property type="protein sequence ID" value="TBU11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1117p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="91632" checksum="B61B011413DAE784" modified="2019-07-31" version="1">MTYGDKQMYTNLKKNVNSHIGLTYILIQIIYLLILLESAFAYKFTYSFEQTEDSAILFFKENEVCDTEKSSNYEVNIIFDVDIMLINKKSHVFTYEKENFISLSILDDILSSNNTGNETKCGIIECNFELSYFLKLTKNIAELPVKLNDDKIKCMLSVLKCFKAVENKMFKEFLNALIFTEFVFINRNDARQSFLNQEELFNLSIKSDYCIIKVIISSFFKAFMIEHVFYGGNLILLEEPGVNFDVSFFDIHVPYRNLLINNTKIFFILENILQNIRCRNIFRFVLNSIDIRSVIINYLQESRILNSSILFHILRFDMLKSIIISNFNTSSIYFVDKLFKVLDQNIDYLSLKNTVVNKNVLDDLFERLKLKGLVLFGNCLLEGPDPVENYLYFNKTLEYLNLKVLNACFSWLLNVFETKNLRKLILTFLTSNAQKNFMKEFCKVNKNTNILHIEICFFDELFYSFCDSLSYFKSLQTLIISRFKTDGYTESCLIKAIKSMKNLEHIEILHHGVSEKFYNFLLQKRGIKNIVLKNFIYSPNTLKFDSLNNNVSISEFFLNNVKITEDSLIEICKCGTLTKLKLNVCNLEPSLVSSQYSLLLKNIVSLYLEDSNLAIIKNMNILTQLNCLETLYISKCGFSCGYLAKLSSSCNLKLKSLSYISGILDANDLDRIKKMEVLRELNLSGSKFKKCGFYSLGHSNKFLGFLKDLNLNFVKIDLEDLKLIREFRELERLTLTFSNVNMYTENGFVVSHNLYRIASKNINDMSNYYKLRCYLREEVAGVYFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK8</accession>
    <name>A0A4V2JXK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0853p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000853">
        <property type="protein sequence ID" value="TBU12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0853p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="755" mass="89895" checksum="76C9C5F8924ADEF8" modified="2019-07-31" version="1">MSFILLLRNHIFGLNVKILDIKEIKDNNPFFYTGNKYFLDIKTCSLVKNYNPAYFLIPLTPKNSNKGFSISYPKDILLSFEFFDELILNNQEEVTIYMNNVDIPVFSYFLKLSKIEDFSILKMKSKYFFEILKYLNIFNIVRNKSYKQFSKTLVYYSIICNLGFDKEASELILNPNCYNNLHVLDIIECIFVFYLFKTSLIFKIFHDYESFEFSSSIFRHKEYKMSRNTLFMDYKHLYSSKYIFIKGFSSVWKIMIKIFFIDKLYLDLYSSESDIYSRHFISSIPYNFKNIVIEFLEKEISLLDKIYERGFLHLAKKVKIIVMVCSKDFIKRIHYFENAQKLVLEFLDINLDEILNIERSIELKSIKIIKINISTLICVQRIVPAFSLSGQNNNLSIDLSDEMLICDSRNFLNIFSTYNFKNYLTGIDLSLHHGSFDRIYFEKILNFKLIKRLKMDLENVKGNRLKSYKFLELFQFLTKLTLKNIKLTNKLFKIIIRSKCLVSVVFEGFRVTNRNKNFKNFNESIIQMKFYDPNTCLSVHLFTFLSKFRRLKHFFFTLYSIQENNDRIYSIYDKISNLKVVRPKDFLNLPKLELLKYENDFDSMHTAPFSILNIFSNCFDLENIVGLMYSTACLFKEDIEIFSNFKALKNLELNIHKNHLNLKFLQKILQTNIKNTIVKFVILTDTYQQTELISILCFKKLKMLELGISSEDIRNIRKLDLLFGMNLVKIHIYALKKRCFFGQDIFARETLFSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR7</accession>
    <name>A0A4V2JXR7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0614p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000614">
        <property type="protein sequence ID" value="TBU12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0614p0010"/>
    <dbReference type="OrthoDB" id="2375545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051620">
        <property type="entry name" value="ORF904-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372">
        <property type="entry name" value="ATP BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372:SF2">
        <property type="entry name" value="SF3 HELICASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="114140" checksum="8EC69AEE6FA29EAD" modified="2019-07-31" version="1">MKTITKTNEEPGSEFELETVIDEWHEENLVFGYTTSIFGKRMTISGKDNFLELYKREIPKGYFNEFIRANAKVVLFFDLHSKEFQLDSLVDDIKRLVKGYFSGFDIQFIVSDATGKEKFSKHMIVRLFKEGKEYVFMNVSEVLSFVREHLNLPGVDLNVYKPGGCLLRAFGASKEKVGGKLVFDAKHTGPRKELDLIEHFVQWPGELGECIRTFISKQSFSCFKEESLVCNNQAITKVEGRTSDSKNSLFLKLLEWFHFKSKKIYRPRESEVKDGMLVIYVDVEPLDVCPYNVMHKSNKTYLRITVVNAVLKCHDCRLKSKNHLFEVKLEDVLNKEEIYILFRGNILQKQLLNNTHHLFLSKDPKAGLPIYNGSENSVRSKVGSPEQVKEFLGIESINMDTYHNLTASSYSVVSQDKSIELSFPKEKHITACQKELKRFSKNFVELNIYQSFTPNTTINNYVLDKNMNSVACLEEMYDKPNYIEIVYDEGYFLKSKLELDLDCEDSFLRIFMDSPTPVFFARFLTVVLGGRAIVVGDNLYVANINNIYKEYSKEATLGILAYLSEQFLKGLDGSRKLLKAQHANKDCQDRLFSKYLTMRLNLQSPAFLKSTMSVLFPYIRDEEKGLKFNTKFKLLPLKKGVFDSELRRIRETQLDDYISITLPFTEQDLLFSDHKKVAYLFLDNIFKNECEIEYVLNELRIILFDDSNDKVYFLIGEGANGKKTFINMLRIALKNLVGDLPVKALSNSKTSAMNRFFVNLRNCRIGVVAEYGSKILRVDIIKRPAKYERITVGSLYANPVTFPFKTRLLFVGKNLPKFSAVVDYALERRMKYIYFAKNLSIKENIKNHLELSNESVRHAIGLGLLQLILKEPINKELQIPTTFLRYASYAFGESRPFTKFLETVIKEATEGYITFFEVYCMYNGLDTAHTPKDVSRKDEYSAKFTEFKSYVKAKFNLDESHTRSADRKSIRVFKNLKIVSDNLNEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT2</accession>
    <name>A0A4V2JXT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0554p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000554">
        <property type="protein sequence ID" value="TBU13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0554p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12562" checksum="267818C13278459C" modified="2019-07-31" version="1">MKQVEEGEWNILMSFNNQLSRSIIVEDEASTIESAIDIDPDIILVEENAADTQWILEIALDVHEESTEMHFRNYRERIIRSNNSNKLKRDLSIGDQVLIKKRLRSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU5</accession>
    <name>A0A4V2JXU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0513p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0040"/>
    <dbReference type="OrthoDB" id="2195960at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="384" mass="45350" checksum="F0E6C152A73AAF61" modified="2019-07-31" version="1">MQAPVFPLFNLKFYKGKVFACGGGGDTRFGKSNGIIVLDSTTYEDISYFESSDLLINLKIYDPTEIRDELQEDTISFVEEERKIQQSEPKVELEETEIEKRLYSKTNDMLYIATYGTDYFYLLSFSTNKFEILSKLKIKITHVFFNCYMFIQTDTQVYGFSNPTSDPTALKRLKYLIKKPTDHPNSPKKNTSDEFIYSTFKNNKYIKFRKENNDSIIKQDFSTYFITYNKIHKILLINHKYTFIFQNVKREYSDEIKEIFYNRRNKLLVFYLKGINSTLHFIDKSNQEYIFKISKITCINVNKKHVSVGTGDGYIHVFRDNVFIIKRRVTDVPITGVDYNEGFVYFCTFYGAIDRKKIDKFEWWTLVLLFAIIAIILGLVRYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX2</accession>
    <name>A0A4V2JXX2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0432p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000432">
        <property type="protein sequence ID" value="TBU13432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0432p0010"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="45365" checksum="9B108B8A95A558FB" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKILGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDFKIRNNKPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIILYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRELEASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEEKIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY06</accession>
    <name>A0A4V2JY06_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0349p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34723" checksum="E742836748664E96" modified="2019-07-31" version="1">MQDNTLKNEKFCSNVSDSSRWLKKVNIRPHNEAMFCYIQDRNLFWGADGVCQHCGKSGKTVDHLATRCQKMLGHDYTRRHNEVSSKRIRSHSVQEIIDNECAEIRVDHRVKTDVKIRNNRPDIFILDKKKNMNTLIELGITSQDSLQIVETKKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLGSGLNAEESWERASMGVILRSEMHEDSAKNFKPKNKAPFISQGLTNLEEPNNNINEESDSEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY58</accession>
    <name>A0A4V2JY58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0182p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0030"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="26118" checksum="29F62901D66D7AD2" modified="2019-07-31" version="1">MENVEGNLLNLEKRDSKYKQLTKEQRQGILEKLLLQMKENKLKHARPRYDAHRKHYFEGKLEYGYLFIQNQTMIAKNVESVTAVHCKKMIIENVIPVIKSKFPPAYKKKTMYVQQDNAKSHFSDNDADIVALGSADHRNFKFKAQPAKSFDLNVPDLASPHTIDELINCVQDAIHQLEANTLDNVFTTLQACMKSIMLADGGNGYKIPHLSQLLEKYVSSKKQTINPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY65</accession>
    <name>A0A4V2JY65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0171p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000171">
        <property type="protein sequence ID" value="TBU19923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0171p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="27402" checksum="8FED6131AADEA436" modified="2019-07-31" version="1" fragment="single">KEEGVSNSGSSYKGVSNSGSSYKGVSDSSKEEGVSNSGSSYKGVINSSSSYKGVSDSSKEEGVSNSGSSYKGVINSSSSYKGVSDSSKEEGVSNSGSSYKGVINSSSSYKGVSNNIDKQHPVNNNTDTQHPVINNTLYPVNNNTLHPVRVLGVRKGCMYLKVLDGDEYVEEVMVIERCYMGRYIKGCYLRGCSVIGYCFLIPFKESERIIEFKRRMGVVSRVIRCNGEGFYVMEDNEVMEVSNEEYVMMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD3</accession>
    <name>A0A4V2JYD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0028p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020252829" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112893" checksum="BE506847699656AE" modified="2019-07-31" version="1">MKQISHQKQENIKEMPILLLFLTSTMAQHCDCNIYIPECYNICNMYGGRYLYNPNVYIKGKPPNIAIPVYNGYYRTPSISILKPQTNTGITYNNNTPINNRNIRGVSYSNVSSNNNPINNGNVRGVTIVPSNTNYNTPINNRNLRGITIIPSNSSNNTPPSDRNATTNNNTSTLDNNTSKNRNIIRIYNNKIEDTKKSTKIKDSMNNIDSTKSTNTTNNTINNTNSTQTSLVTISKIPYSTNIEEICRLLSWLNGYQQSSENKITVLNDSIEKIKIKIFEIYDTDNIRCKISNEGTYNIFSDSIKYKSVTSEIVGNRGVNSTVCNNGTLCDSTSYLNKYGINAPNTSTVCNNGTLCDSTLYLNEYSINTPLNSYKSISYSRYSYVTTITPFKYTYITEYPNTSYITEKNKGVNTIHGNKTPLVKWKKKGHRNNTPLARRKMKGHRNKTLEITEYPKTSYITTTMCFTTTPYKTIYVLRDNKGNISSLKKKRVGSKSTVFNTLCSTPTVDKTLYNTSNDIETETSNNTVYTTSKDMEPETSNKAHYTPFDNTTTVIISETVDNTLYTTATINNTITDVKSETINNTLYTTVTINNTVTNTMKETLNNTLYTTVTDTKKETINNTLYYTVTDTKKETVNNTLYSTVTINNTLIDTKKQIVNNTLYTTVTDRVKETVNNTLYTTVTNRVKETVNNTLYKTVTAIKPLTVTNTLYTTVTNTIKQTVNNIIPSTVTITDIKNNLIPTTITKPDINNKARNKNTITTLVTYYTTTTIEYDIYKETTSYDTESEITPLSIGVSSSKLKPLSIGVSSSKSTTLSIDISSGKLTPLKLVDSCSKLKPLSIGVSSSILTPLKSGDSSSILTPHKSTDTSSVLTPLTSSTPTPITTNNLTPDSSYTTTTSTITPFTFTLPLVTDNNKTIMIEELKGLFTQLIDLEKIRSDTDISSMTPIILFKSHSTNKNLTKEIKTCVLTSEINSDQNSLNNQSAKTDTFTINNDSIINNFKLFKDIIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KRA0</accession>
    <name>A0A4Q9KRA0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Microsomal signal peptidase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_2439p0010</name>
        <name evidence="13" type="ORF">CWI38_0508p0050</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002439">
        <property type="protein sequence ID" value="TBT97188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000508">
        <property type="protein sequence ID" value="TBU13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KRA0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KRA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2439p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0508p0050"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT97188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="155" mass="18127" checksum="B26BE9EA2ED65839" modified="2019-07-31" version="1">MHTVGSRASACLGFIFNATTALIAMVGLVGFLLQRSPPNSEFKVLKYQPYMTLTPQSFTFIPNIDLKEEFNPNLKQIFFYVKVVFGKNKENSEMIWSKIVTRKDEKKFFEAIKSNYRLSNLESYETLDFELRGCYFPYVGMIRDICFKTYIFDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4W8</accession>
    <name>A0A4Q9L4W8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0446p0010</name>
        <name evidence="2" type="ORF">CWI38_1877p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000446">
        <property type="protein sequence ID" value="TBU02603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001877">
        <property type="protein sequence ID" value="TBU10283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4W8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0446p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1877p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28166" checksum="AC03411394909B37" modified="2019-07-31" version="1">MNTTSDVLLLEFFDDSRKLIQISNQPSLHFGTKEISLAGNEMQLEIIHSLKNFKVLEYLNFSNLKNISMENFYCDCGFKLYLIEIDLSRNMLSRSFSTFSSQFSQLERLNLSNCDLETGLLEFLGSINLQISVKKLELAKNNLTKFDIYQIYLLSNLKYLTVSFDGELCSDFIKTCGYLKFLNLETIVLVSTNANSDICNFLMIQPSLKNLKFIVCNIEAELWTDGFITFANSLETVTVTNNMLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBH5</accession>
    <name>A0A4Q9LBH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0041p0020</name>
        <name evidence="2" type="ORF">CWI38_0804p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000041">
        <property type="protein sequence ID" value="TBU05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000804">
        <property type="protein sequence ID" value="TBU12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0041p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0804p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="122" mass="14770" checksum="B658A7595FCECC2D" modified="2019-07-31" version="1">MNSKRNCKNRKPEQKERMLIIKAIKRILDEDDEYLNAAMLKRTDIYLFSTLKEIIPVFLKMVRDTMIFEQRAVKIGNIAYQKVFPLLKEAKEILYNYYCNFLYFQIDLDSNYYLNLLVSFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDK6</accession>
    <name>A0A4Q9LDK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyadenylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0025p0020</name>
        <name evidence="4" type="ORF">CWI37_0046p0030</name>
        <name evidence="7" type="ORF">CWI38_0717p0020</name>
        <name evidence="6" type="ORF">CWI38_0791p0040</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000046">
        <property type="protein sequence ID" value="TBU05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000025">
        <property type="protein sequence ID" value="TBU05306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000791">
        <property type="protein sequence ID" value="TBU12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000717">
        <property type="protein sequence ID" value="TBU12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDK6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0025p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0046p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0717p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0791p0040"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="310"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU05306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="538" mass="60902" checksum="C94583D9031E4807" modified="2019-07-31" version="1">METKNASTDGVPTNTPIYVGDLSPKTLESDLYRIFSAVGTVTSIKMINIATDIVNPHASKCYAYISYLKKEDADNAVMELNFTELHGKKMRVMHYDKSLVKSVAGKNIIVKNLPDSVDSQLLYNTFKVFGDIMSCKVPTTSKGKSKGFGFIQFKDPASAKKAIDLANKCLMRGNKLKIEKYVSKDKVVSGKNVLENKFTNVYIKNFPSNITENDLTNILTQYGEITSFYMPLKENGQPKGFAFANFSENSSALEAIKNLHNKYVFTETEDDSVKCQEPFYIQRAQLKEEREEEMRNYISKMSLEGQNYKRNLYVTNIPSCFEELEVKDVFKKFGNIVSFALGKDFNVENGVKFAYVCYSTPDEASIAVEKGNEIYLDGQKLSVAFFKNKMERAAAREINSDSFSYQPDVGLGYSKIGMFGGSMPSFFNNMKENIISNGDMGYGNRKPYEDKKQLENDLYGVVLQMAPTFSKEWPILGVKNEEEFSRKMTDLLIQRPSCEIKIMVGLGNILDFNIKQTLNSYGENRDSDSSKIFKFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDW6</accession>
    <name>A0A4Q9LDW6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2732p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002732">
        <property type="protein sequence ID" value="TBU05645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDW6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2732p0010"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="24185" checksum="0FD9F9B360425D47" modified="2019-07-31" version="1" fragment="single">DDYKGVNTSSKLEGMEEGVNDTIDDYKGVNTSSKLEGMEEGVNDTIDDYKGVNTSSKLEGMEEGVNNIIDDYKGVSNSIDDYKGVIDSTHKQQGVNISTNEQQGVSNSTYKQQGVNNNYHLSNKSINPNLTNNPTNPSLTLETRINRITLKNTKILRFIPLILIIFIGISISSAVGFSRIYDNRHHMHDVVCGGLLGICSSVVMFYLLCKELKVKGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI65</accession>
    <name>A0A4Q9LI65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS_1-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2525p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002525">
        <property type="protein sequence ID" value="TBU06680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2525p0010"/>
    <dbReference type="OrthoDB" id="2192003at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="7"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU06680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="49632" checksum="2F79BCD69E78568A" modified="2019-07-31" version="1">MDKEVVQMALIYLSVSASVYCAHNFMYSFLKASCSIEIHDFSMLDTLEVLRLIGGFFWTNLADRTNKHRIIAIINMVGYAVFLNLLQWAPWFMKAKELNIWTIIYRGLSIFFQCGIYPILDAVILEMLEKNGKSRKHYSKIRIASTLGHVLAHLAVISVSYIFSVKQKDEKVVLILTSFFVLVTSILIFFYFSDVEKKETKKNKFPLKIRIQRNLKYVREILTFSFILFNITGTLQGIYRNAMTSFLPAHLENIGMKNNSIRGLFILRCLPEIGMLWITPYIERFVSIYVMMLFGICFGVFRPLLYGFAELKNLGQTGIYSVCILNELTKGIFSALYGYGSSKMAKEFSTEKTKALAQGIQGGCYCGLAPFICGLMGYFILKYDLFEYRGNSLRGFFILTGLLGCFGIFILLVLINNRKKKEKMSIGSSKICAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIK6</accession>
    <name>A0A4Q9LIK6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2319p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002319">
        <property type="protein sequence ID" value="TBU08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIK6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2319p0020"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="617" mass="71563" checksum="E889ACE1A787CC87" modified="2019-07-31" version="1" fragment="single">MLWSYKYKPIYFKDLYFKDNLHLQCATWLSQWTRNSSFLILSGPSGIGKTSLAYILANTYDFNIIEIDNTTIKDILIISKGISLNNKKHILIIDDIHITSTSNTPHIINILNFLIKNKSKIHCPVILITNDLYSIPFKFSNNYFLTVNFKIPGKREVEGVINKCIEDNNITIDYRAFQFLIENNTDIRSVINTLQLLSSKDKDYKNYNDRSIIGGDNNSNSNHKGVSNCDDKQQGVSNNTNEQRGVGNCNNKQQGVSNSTNEQRGVNNNTNEQHPVNTITDKQHPVNTSIIISLTDVEKYCKITQGNIYKTVENIFRKKLEGFKELNNIYKGFGDRLSVGCFNTYLSKYINTEETNKENSSNNNDRSNINNTIIDNTIGCRSNINNTIIDNTIGCRSNINNTTIDNTIGSRNNININTIKDNSLPKKDGNLLNKIIKISDFNFYYERFPEEYNYMLFGTYNTLFRGSMSVRVDLSVKSKCVHKRKVGHDYFYYEIDPYLNWIIKNENLDFEYLKEISRKFNLKDLNILEKRCYEIKAKQRVFKYKYKEGVSKAGIEWYLKRRKYKIVNKAGIEWYLKRGKYKIVSKAGIEWYLKRGKDKIVSKAVKIVINKRELNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ87</accession>
    <name>A0A4Q9LJ87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit 3 of cleavage and polyadenylation specificity factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2284p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002284">
        <property type="protein sequence ID" value="TBU08268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ87"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJ87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2284p0020"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="15914" checksum="39021F779157C780" modified="2019-07-31" version="1" fragment="single">MFLDEDIKITPLGAGNEVGRSCIHIAYKETSILLDCGVHPAYTGLSSLPFIDKIDLSKVSAILITHFHLDHAGGLPFFTEKTNFRGKVYATHPTKVILKYLLNDYIRIINASSDTDFYTERDLKSCIDKIIPIDYHQEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLS2</accession>
    <name>A0A4Q9LLS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1849p0010</name>
        <name evidence="4" type="ORF">CWI38_2306p0020</name>
        <name evidence="3" type="ORF">CWI38_2509p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001849">
        <property type="protein sequence ID" value="TBT98217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002509">
        <property type="protein sequence ID" value="TBU06778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002306">
        <property type="protein sequence ID" value="TBU08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1849p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2306p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2509p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="84" mass="9883" checksum="A8A9320E05F226DB" modified="2019-07-31" version="1">MNYFFIFGFFQYLIGSIDSNTKENVEQIKDDNQGSKNEGDRAHGFEQENNSNRQNTDFDQNQRKLSEEEKELYFTLNVIAPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM57</accession>
    <name>A0A4Q9LM57_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0411p0020</name>
        <name evidence="13" type="ORF">CWI38_0409p0030</name>
        <name evidence="12" type="ORF">CWI38_2242p0010</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000411">
        <property type="protein sequence ID" value="TBU02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002242">
        <property type="protein sequence ID" value="TBU08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000409">
        <property type="protein sequence ID" value="TBU13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM57"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LM57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0411p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0409p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2242p0010"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="311" mass="34550" checksum="2F257950E1D19EFC" modified="2019-07-31" version="1">MIYSRRKPYNPTCDNCSESQFVTEDVKHGQLVCTRCGLVVGDKIIDEGSEWRTFGDSNSMDPSRVGGPNNPLLECEQLDTLISSGSGLNSYTLSKTQMKSSLRGPERALIHGFNLISAFCDRSNITKTVMDRAKFIFKTVEEKKILKGKNTESVVAACIYIACRQENCARTFKEVSVLTAVPKKEVGRSYKLIFPHVDKMAVVSTEDIVARFCSDLNLGIELQKVAVKISRGAQQSGCIAGKSPDSVAAAVIYMVTHLFSNQRKVQKDIQHVTNVTDVTIKNTYKELLPYKYEIIPEGLVSKYQIDSLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMV0</accession>
    <name>A0A4Q9LMV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative apoptosis-antagonizing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2148p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002148">
        <property type="protein sequence ID" value="TBU09447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2148p0020"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22464" checksum="51C33F310602D1F8" modified="2019-07-31" version="1">MPKEESSNFNEINITELQRKIENLLTVRIKLEPLLQKGKDSFNKEDLSTFIDLKEQIELQPNLKEKTGKIINKAINSLNKINIKLNCTSDKENKVLFGTLKNQINLMTEELKQKHSNKFCDSKLFLNLIKHRSERFNFGKKSNKITKNEKQSKNKKLSYEYHDKMENFVVQKGTVQWPEEKIDNLFSSLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPB0</accession>
    <name>A0A4Q9LPB0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_2158p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002158">
        <property type="protein sequence ID" value="TBU09351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPB0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2158p0010"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU09351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="324" mass="38557" checksum="73DA3DC5497BEFA4" modified="2019-07-31" version="1" fragment="single">KPMNKEYLATLPMEQRRAIEKAYISVVNKEISPSEFFNYCKEILGSMKYSLLFYNKPLEESPSTPKQSTREHNNNGSADLKTEHLQDIIQYTGVDLKEEEEKIFKDSEHNIGNSYVQDEDKRNKMESLLNLDLFIEFIKKICALRNISIDNDCLYVLFMALKRKLLELLEKMEEVSKFRVDSTRGEFIIRIENDIRRQLWFLEEKEKKEMEKLKIKKFESEDEGRKRVKRTIQEREDLLIKKRLSNNVALAALGGQQKSWMNVENIPISKEKESPLQSLYSPFDEKEQERKISMRSITMSDFLYVLEHDKRYNKSIFTIQQYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPW6</accession>
    <name>A0A4Q9LPW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1724p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001724">
        <property type="protein sequence ID" value="TBU10489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1724p0020"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="11577" checksum="EF7EBD39F261774F" modified="2019-07-31" version="1" fragment="single">MKCNINRIEGSFTSTIISDMSETVEYNLCGKYSECEDFGFLESSEVFGVSGCNTSLRFKEDNIFEENNFEENKESFVFNETNFEEKINLEESIFERKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ03</accession>
    <name>A0A4Q9LQ03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1876p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001876">
        <property type="protein sequence ID" value="TBU10287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1876p0020"/>
    <dbReference type="OrthoDB" id="2196277at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="51934" checksum="C54855B603D47B62" modified="2019-07-31" version="1">MDTSSDDIIEIKSIKKVTNKRKIEASDIYHDKSSDSDIIFVRAEENITAEKKFICTDQNRVNQDNILNGNEKNENAKKEKVVSKNVAQQKDLRNTSTILEVTKETDKDKYLGSIESNCEFDRDISAEIEECKRLMPNTSNNEETNDSSPEIKEIKSLTLNILNSQDGSDISSEIDGYESPTLDILNNEGTGYKSETEDDLDSIFNLNKNRILQQNDNSKARMKTSIEEIKNTNCTSIALNESINVHKKDGKCNENETKEISTGYKMDTPSKNYNKLKCIDIKNYSSIISDVPDNKEPIRKKEKDLTKIFIKENGNLTKYFFLSKNQTFEEIYKEIIGYDLDKKIFYKNMAVSKYSTLENISYNDCDNIFEIININKNVNNLQEIEIKVNYDFNKTVSVQVDRNQKFKDLLQMCTSICPGYNFKNVMMNGDTFDMNEIISNYLESNDVIDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ23</accession>
    <name>A0A4Q9LQ23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative subunit Rpb11 of DNA-directed RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1394p0020</name>
        <name evidence="6" type="ORF">CWI38_1698p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001394">
        <property type="protein sequence ID" value="TBT99297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001698">
        <property type="protein sequence ID" value="TBU10528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ23"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1394p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1698p0020"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT99297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="101" mass="11892" checksum="C472EEA7F63AE5C4" modified="2019-07-31" version="1">MTEEIKKLTIEYDKKTPNTVEFIIHDESHTLANMITERFLKDQRCTFSAYKIVHPLDNNVHIRVTAIRSINVKSLIIEILKSFETEINELCEQFVNLEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQF3</accession>
    <name>A0A4Q9LQF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1760p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001760">
        <property type="protein sequence ID" value="TBU10437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1760p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="67" mass="7694" checksum="AEC6791A441C1D8F" modified="2019-07-31" version="1">MKANTHEFKEIYSTFVLKKTVETISFDRRKRIESEPNAKRAEESVGGCFEESLKAPATKINFKISEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK5</accession>
    <name>A0A4Q9LQK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1026p0030</name>
        <name evidence="2" type="ORF">CWI38_1726p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001726">
        <property type="protein sequence ID" value="TBU10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001026">
        <property type="protein sequence ID" value="TBU11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1026p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1726p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="21059" checksum="B00E8DB2A5170AF6" modified="2019-07-31" version="1">MYFLHLILLNYYFFLRIRNNRPEIFILDKKKNKITLIEVGITSQDLLQIVETINLRKYDLLANELGLIYRYGIVTKYHKSHLKRQEITMNVEAYIHSIVLKKTVDTISFDRRRALDIRPNAEESCMRASMGVIMRSEMHEETKPPLKEAKRQEDGGKNLKPKNKAPLISQEEPLRGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT6</accession>
    <name>A0A4Q9LQT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1502p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001502">
        <property type="protein sequence ID" value="TBU10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1502p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="9706" checksum="144F5C14512A0CF2" modified="2019-07-31" version="1" fragment="single">MAKKKKNQENDFLGDLLKTAEETSDRSNIKEENKKEETSDRSNIKEENKKEETSDRSNIKEENKKEETSDRSNIKEENKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR79</accession>
    <name>A0A4Q9LR79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1395p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001395">
        <property type="protein sequence ID" value="TBU11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1395p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="528"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="869" mass="100201" checksum="4BD657C1E9E5B84D" modified="2019-07-31" version="1" fragment="single">NKPKLPCPYCFSLNTSNNGTGKNLNDPRTYCNTCKWSYSTQIAENFAYAFQNKKGKINESVNSNIGVTKKTSDPDINKVLNSSPEEKFTNLNQSKLTKEQIALVISGESSFPITKYIFVYFTGIKRGLSVKKIEIINCVFLDNKLDILALAETWRDDIDNLNTNYWIAARLLSKQVKKRYSNSEDILILAQKSIYPQIIPSITDFGICIKINDTLLIFIYKLPAGFDVLALGDYNLKNSVAYEQIVLEQHAELGLYETKLAPFTYKHGSKTSTPDKCFSNFNVSPVVIEIEGINHKLIKVQVGRVAAQLETNYNINLLKNAGTLREVRKRIETLTIKNEYFLNTLSIDEKLNLLHKILLKAARTLQIRKHVQRVSHNPILSHLKRLRKRKSANKDAQSVQLLRKEIRRLSRKLKRLGVEEGKVKHINLQPYELHKLICASSTKRKISERQMKFAELLFNEEELVPVSETKKKIEKFYLSINKKKTQNLLDEIKNLKLGKSVCLSGIRNELIKAFPMNFIGHLSVLFNQIIFEKKVPMAWKCHRIKLIRKEMKSYRLIALIEETRKFFEKCIQRKLSFRLSTRQTGFRERHSLIDNALGVDHLFRKGAGELICVSLDIKASRGIPQGSVLSPNLYNVFIDDLLLYIPQGLRKNLFIYADDIFLVGTTYELNQQKCFYNANKRCQIVVNGSPIEKQSPMHYLGYYFNLKGTDTNSSIKETRKKSLKAAIIMKNGLIKKVGVGNSEYYRLLLKGYVTFIRPHLDHTISLLDANKTYNTYGKYAYITRIIPMKLLKDLKNDFLIDNITLLKQITSLGFYDLNNIRYNDFKRLLNIIKEEKFIHIQDIVAFFYCPKPKSSYGMLLLSHTNLNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE9</accession>
    <name>A0A4Q9LRE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1517p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001517">
        <property type="protein sequence ID" value="TBU10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1517p0020"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="835"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="1171"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="1053"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1319" mass="148235" checksum="D73B4831D13A503D" modified="2019-07-31" version="1">MFNFLFISISFPLFIFIYRIFFKSSKKKEQPTQIQTPHQHTNTLLTKIPIYFFHPSPHIFFKTHILQPQSIFSLPCILLNGKIQIKTHLPPYITTTTHTSTPILINGPLHLLTNTSLSFTCLVSTSVISFNQNIYPSLYLTPILIYHLRSVISMLISYFHLMVYLAALDVKIETCLTNFILKNKNIKEINLPAGYIYKRYGVPLDTVFYVVKGSLVIECDRGIEGFGVGQGLGGGDRGMSEGDNNSSKLEGDNDNDMLEGVNNKDMLEGVSEKYGSQQGVNKLSNEQQGVNKSTNEQQGVNKSTNEQHPFNHTPNNNSSVLSDTENTKFVLQKNTFFSVLNIFTPCYTNTTIRTLTPVTLKVLNICHITLEPINNTPLFSSHINNTLITNSTDNNTPLTTPHLNNTPLFTTTLNITPLFASLIKDPILTLADRHCDWIRYMPGDIIVEKGCKSLYAYFIAYGLVKDNTNNSFYSKMTLGSKEVISNSKYICTYTAVKITDIIRIPRVFIDTVFCTCPGVSMMCVSDVFKGDVKLPGKTVIVVPGGKGRGVSDRRVDGYMGVKYKDRDYKGVNKRVDDFKGVKYRYSNIKGVNNVNRKEEGVINSSNEQHPIIDSSNEQHLVNTSTYEQHPVNTSTYEQHPVNTISNKQHPIINSSNEQHPVNTISNEQHPVNTSTDKQNPLNNPSNEQHPVNNTPLLKYNSGCNSADYILQNTVNHNTCLDTLLFSCRLRTVIGKRCYFITSTTITRILNRNTFNTLSSLIMTQYLEHIEQSYSVIVIYIENRYSRMFKMLSKMCNVILVVGEGDILLEEGCCCSVERVRLYEERVGVNDRCDKDSNIKGDSNDTNIKGNNKGDRDTSILKGKSKDSNIKGNKSTGDIKDIMSVNISTSNIKGVNDRDMLEGDNDNDMLEGVSNTINEQQGVSKSSNKQQGLNNVTSTYHPLNNTPNTYHPLNHLDNNPTDKSIGKYLMYDKNPNPTITKYLIPTYTRIHHVVSPSRNDRLCLKDYERLARYLLNKRIGLVLGGGGARGYAHLGVIRALEENNIPIDVVGGTSMGAFIGGLYSKDISSISCYKWCKKMSEFMSSKWRFFTDLTLPLCSMLSGYNFNRIIKYFFKNLNIEDLWLEYFCISTCINRYEEVVHDKGILWKYIRSSMTLSVYLPPMNDKEGMLMDGGYTNIVPGDVMIKKGVSRVICVDVGSVSDNKYEKYGEYCSGVIMMGDIQYRLAYVNSEGKLRDLEKSGVLIIKPDIPFSGMDFNKFDEIVECGYRSGGEMGFIRSTLVGVGLGVGMGCLGDDRGFIDDYRVLGVSNSIEDSKGVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI0</accession>
    <name>A0A4Q9LRI0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2057p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002057">
        <property type="protein sequence ID" value="TBU10060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2057p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10795" checksum="04E0DF95C515765E" modified="2019-07-31" version="1" fragment="single">MKYLKDSMKWLYSKVTDFVLQETTEEDNYDFTSYINRSNDVNKINTTSESPSAQEILNDLFNQGYYCRDEFLERKRKEELKNESKESSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ8</accession>
    <name>A0A4Q9LRQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1929p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001929">
        <property type="protein sequence ID" value="TBU10225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1929p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="475" mass="56580" checksum="725633E67652C7E0" modified="2019-07-31" version="1" fragment="single">MLFKIDSENIIKVLKETEDSVKNSDIDMIEVENFYNDNCIKIDTTTFKANKYEKQYYGEELEKFNYSFIINMESDILFFRENQEEILLNEEIDNDFGFEIFYDSYIKHVNQDNCIFRCTKENFVNFEELNNISFSNSTKNKFKIGIVGCSYELSHILKITNDITEMPLNMSNYQFKCILTTLKSLKAVENKNMLKLLQVLIFNYFVHNLYNGSERKPLLLQETFQDDFFENLEFSTTKNFIFAFLNIFMIKYSFENGNIILVDKCKEYYDNTLLNKNIPYKNILINNFKVVYILENIFKNRCILCTFQILLNYLSMKSLIVDNYTNLEIYEQNYNFAIFSINVFKSISISNFTNQSAVRFLDRLSAVIRNDLEFLCLINLQITRNAIRLFLNQKKLRGLVLRGIRKIEDVDFIQDYTDCGKKLEYIDFKNVILKDTWWNYFLQVSNVSKLILCFCTLLQQNFFLKEFVKIVSDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS14</accession>
    <name>A0A4Q9LS14_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GHMP kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_1693p0010</name>
        <name evidence="12" type="ORF">CWI38_1273p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001693">
        <property type="protein sequence ID" value="TBT98572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001273">
        <property type="protein sequence ID" value="TBU11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS14"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1693p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1273p0010"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="10">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT98572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="309" mass="34541" checksum="48D7E3F8E0AD21F3" modified="2019-07-31" version="1">MTKNLKISAPAKLILFGEYAVLKGSLCIVAAINKKGYAEIRNGTGTITCTDINGRECNMKEITGEILPKNDISIFLNLRFGCGLGSSAVISVLLSSGKYLSEKYDLNKENFISQNITEENKCNKAFEIEEKEVFENSIFIENIFHGKSSGVDVAACFYGGLLCFKDKEIEKVDSKYLKRYKILIFDSKITRNVANVVKKCPVNINKDLILEEMSQISDKAARIISREFLLPEIYPLIRRNQELLEILGACPESMKNELLKIRKRGVEGKITGAGHGGHLFTIVENNISFEGWEEVKIVDDGVQFSNSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS65</accession>
    <name>A0A4Q9LS65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1225p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001225">
        <property type="protein sequence ID" value="TBU11403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1225p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="312" mass="36055" checksum="288F46C5BF9C136F" modified="2019-07-31" version="1">MCDNKINIFNSLTWISIQVVAHMKNEADVYFIYLRFNLGGGLNYKIHKSDSINDANSHTINHLLFIDDLKPLATDSRGKGTLKVIEPESTMKSQPRMMRIMKDSRSNPTRSSFNEVQSKLISRVERLCHTRLNAKNLLSAINQHAISLINYHVGVVRLELANFSKLDDAVRAVIELGRDLNSVNMLEEELYNTRKNWLVSDYFAISRIEMYYGKQIKMLSHDYTRRYNKVITLVEFGITSKDSLRIVETERLGTGSHLKVCMMNQPLSLKRSEECVRRKNINEESDLEKEETVVIKEGRKIKSQREILTQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS81</accession>
    <name>A0A4Q9LS81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1814p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001814">
        <property type="protein sequence ID" value="TBU10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1814p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="40693" checksum="D26BD57D4F75CE8B" modified="2019-07-31" version="1">MSLLENTFNYFHSDCVSCISINSKNLYVCTKKKLNVWNKTEKTFKTFIIPEEFIKSVSNNLHTFFLSKNCFYCLENDFLIKICDTHTFPCFWLNKNHLVLADQENLTIYTFHQFMEEEKNSVKNAIQKKSFNDENHQILNEDLSENYTDIKFIKNDINYVNLKSDLYLKNKRIFNIFNSKYGIVSCIVEYENRLYISFEDGSIFEIIETCNSPYKKLIYRHTETIISFLFYTKNTKKIMIANTLENLIKIEPKIIPKNEEKMDDNEYLVTSFNLNFNIKKIIKILDYILVYSDQECGFIFNLDFGLKEKIFCGNVKNTKIFENKLFISNEDGCVMEYKFKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA9</accession>
    <name>A0A4Q9LSA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1201p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001201">
        <property type="protein sequence ID" value="TBU11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1201p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="16011" checksum="36D20BAC460A5431" modified="2019-07-31" version="1" fragment="single">MQRPKYRHPISEAQLAKHITKFKKESFIQSNILAIEKKYWQRDRAIFCYIQDRNQGISENTLAVIKVDTRIQTCVEIRNNRTDIYILDKKKNMITVNEVEITYQDSVHIVKTEKLRRYDLLVNGSWLIYNCGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG9</accession>
    <name>A0A4Q9LSG9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1404p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001404">
        <property type="protein sequence ID" value="TBU11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1404p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="32866" checksum="A4DFB3C309A6CB2A" modified="2019-07-31" version="1" fragment="single">KTNDENEDRSLNKPQSKKSLNILKSKNSFSKLPTNKYKRPKISLDSIQISKSTIEHTSSQDSCNSKYNEENKIENTEFKSSESNYKYYKKEENKIYTATKRKEKTKKEIQNNLKTPISNTEHYKSYKEQPQSSNSLSSIKKPEEMRNPFIDQTNNLNSTDSLSSIKRTEETNNIFLNENLLHSSNSCTTDNSNNSDCLTKYISSERNLYLINDTYKSTFKEIQKYSPKFSLNFDEKLKKVVNLKIKLFKRLKKIILRNQNSKIKNLICNLNRFKNMKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST1</accession>
    <name>A0A4Q9LST1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1260p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001260">
        <property type="protein sequence ID" value="TBU11337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1260p0020"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="23439" checksum="F1B4A173381AAF37" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNEEIKAVNNSEISLKQTKTCDRDVVTISETHPPQPTIHNNTHSPSSTTLYVTPVSLLDSAPSSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKFGRTVDIDMLKKLTHNEAEREIRQEENGERRRIPTCLAEPCSLPDTTLYMNLREKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV2</accession>
    <name>A0A4Q9LSV2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1089p0030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="PITK01001089">
        <property type="protein sequence ID" value="TBU11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1089p0030"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="201"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="987" mass="116198" checksum="B87D2CD35CE70F50" modified="2019-07-31" version="1" fragment="single">MTEPTSDLEDSEDKASMAIIKATEMHEEPITILIQNSTNQDDINQQFGFLSYHDFEERNGWLLNYVVTQDIDTSSRVKFYFVDAQKQNFSISIPFFPSLILETDEINFLEEYLRKKYEGEIECTEIISRMDINIYNHLSLKPGNYLRIYFKNEIFFSKAVKDLKKIISKNKVLHKHETIYEDFSFFKSESQNMNINCNIKEIYEYDIPYEVVISVELNIKCGSWYEIKYEGEKYIINPLLYEVPPELRIFAFDIETTKQPLKFPNAEIDEVMMISILTSNTGTLIVNRLIVSEDISDFEYSPKEDMKSEFKIYNEMNEEALLLRFYEIIQDYKPHVITTYNGNVFDFPFIFKRSLKYDLNMGDIIGFNQTRENFVCNFIVHLDCYKWVKRDSYLPIGSQGLKSVAKAKLNYFPDEMDPELMMFSAKNEPQKLASYSVSDAVATFYLYLKYVHPFIFSLSTLIPLPPHDVIDKGSGTLCESLLIAECMKNEILVPPKKNSDDMLFYKGFLVETMTYVGGHVECLKAGIYRSDFEYDFVLKTNSINKLIEQLEIILKDFRNEEFYEEVIKKIKYKLTEYIINGNKSNETAENNFNQSNIENVLVNKIKLREKPLIYHLDVAAMYPNIILTNRLQPYSIVTDENCMRCDFNNKNNLCKREMDWVLRVEYLIANKKEIEMLEFQLENEYFKIEENIKPVIYKNLPQKKKNEILKERIKNYSKKIYNKIYKSNVENKSSRVCQREVSFYVDTVRKFRDQRYFYKKKFQNAKTDFENEKSDEKKEILSKMLVVYESLQIAHKCILNSFYGYVMRKGARWYSMEMAAIVCNTGGSIIKEARNFIEGIGIPLELDTDGIWCLIPESFPDTFLVNKNKKISFLCIVLNYLISQKFTNQQYQEKIIINDCNSEITSDNKSSFINTENFLSSNTILNSDQRKFHIKNKYEIKPYNSIEFEIDGPYKAMVLPSSTEEGKQIKKRYVVINMKDKISELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT06</accession>
    <name>A0A4Q9LT06_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1063p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001063">
        <property type="protein sequence ID" value="TBU11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1063p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="30975" checksum="B42297A0888DDEC7" modified="2019-07-31" version="1">MQDHVTKTLTSSNTQLIAAFQQGKNEMTEKLNTILQHLGQCNTTPNPFQPTNIPPTPSIPTPANPATPITSKELYERLLGVINRSLACKNCCTCTQDAPCQYILAHEIYELPFSESSWPPKPSQSGDWTENVIVEMMAKIRTTRCNTCRDCTTMINRRRLFSFFNAWQFYSLGMPYAPYMPFQQPFAQPFQQPFQQPFQQPFQPAFQMMANPAMPNPYMMMQPTSFMTPFGVNYNANPPLPKEAAKTTCESQKQENNEEAKKFGKGYGKTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT41</accession>
    <name>A0A4Q9LT41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1595p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001595">
        <property type="protein sequence ID" value="TBU10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1595p0020"/>
    <dbReference type="OrthoDB" id="418748at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="371"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="583" mass="67153" checksum="4B3179A3A55FBA7C" modified="2019-07-31" version="1" fragment="single">MCRKENVSSETPKNNKIKAVNDAYKVNKCKSGIKKCDLDPQAISPPSSSYTTITHPPSSQTCKIPSYDMKLLLMAFRTIFDSITADPKEWPRILHRYYDEKFCCSEILEVLKKLAQSEMGKDVKSEENGERRIIATCLTDPYKFFSKIKQILEKEIGKVVVRTRKHPNELVDSKVLDLINRVVGEHAKARVPESITVTAYIMQAAQVCYDEATRKEKPRSSWKENIESKISKLKTIREFNLNLSSVTDLSEALVKKNESVNVYEKKITMHEMNRKFELFRGRFYQWLSVRVESEQVVSRDEIVSFWSTMWNKIYNTVTYDDYLIPFVSDNHPTTFTLLDEFVHIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIFYCGLTHLILKGIPRRGSDYRPITCMSNLYKLTTKVVTKVVQLEVERRGLISKNQLGAVRGVRGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKKIDRGILQGDSLSPLLFVLCMDPLSRNLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE7</accession>
    <name>A0A4Q9LTE7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1427p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001427">
        <property type="protein sequence ID" value="TBU11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1427p0020"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="15353" checksum="84ACFA7349E35B4E" modified="2019-07-31" version="1">MYIDLHNLVITDNDKVEEEDINSKVSKLLRTAFNLIKRIPPTGSGKDFLWEHSTKRIIHPRMYPKEEKKRTRWELFAEKKGINRKKSRNKKYDDDLQDYVPKYGKNSKKNLEKSVGIYEIKSTLKKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE9</accession>
    <name>A0A4Q9LTE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RBBP4-like histone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1134p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001134">
        <property type="protein sequence ID" value="TBU11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1134p0010"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="369" mass="40585" checksum="095CEF86BFA09F66" modified="2019-07-31" version="1" fragment="single">SNSNNPYTNSSRGSNNPYTNSNSNNPYTNSSTSNNPTTNTTNTTTNTHTNPTLELKGHTGGGYGLCWNKIKNGELMSTGEDKLVCIFDINEEGKEVISKLEKHTSVVNDCTFNYFNGHVGCSVGDDRRVVIWDTRMYTCCMVVEKAHSSDIFCCDFSCSDENMVVTGGKDGSVKVWDIRNGKECLYTLVGHKKEVLQVQWSPHFGSVLASSSADRRVCIWDLSSGSVGGSVDSKDKDGISKDSKDGISRDNVSMDGPPELLFMHGGHTNSVCDFSFNPLEPWEIASVAEDNILQIWQKGQGVGIRETGGRYKGVGGVRRGDIRDIKISEIDEKPKPILKRENNREDGDSKIIINKELDVEEEMVGGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG4</accession>
    <name>A0A4Q9LTG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0794p0020</name>
        <name evidence="2" type="ORF">CWI38_1040p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000794">
        <property type="protein sequence ID" value="TBU01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001040">
        <property type="protein sequence ID" value="TBU11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0794p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1040p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="410" mass="49564" checksum="E7CDB56CAF44F784" modified="2019-07-31" version="1">MYLCLISEKLKWLIFLELFVISLSQNFIINSFESKFESNYNLFKDLFEFLNSKDIYFYEIFNSSCTTSLIENIEALELSKDTNMFYLYLKLKNEIRCFINKRTYLLNFIFYESISLRNDKIKTSKNQNLMIFNKKKPLLLLYRTALNILLNFMKIFKKIENIFIASEIELVLAPFLLNEKDFRNLNFFILRQIRSSSSIFDFFILKKSKFFAINIGKQQIKQPINHNMPSSVLYILNETKYRFHEEIEQRFTPNHILNEKLLNIEVYVNTYTIVEINAKNKESYIHESHKKYEFLNYIKKTAKNIHENHNSNEFIFILFGSNAVHLKIDIKEKHLTKNKMYYTARITFIESILFEEYFFEFDEIYSKIGDIKSKISTTFEEFQPERVSNLESLLYRITFYKFWHLYQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP5</accession>
    <name>A0A4Q9LTP5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleolar complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0954p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000954">
        <property type="protein sequence ID" value="TBU11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0954p0010"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="56725" checksum="C7F8DF18089C0BF0" modified="2019-07-31" version="1">MSDDSNLTVLNNLSEDCKKIIHEPEKNILLVTHILNCSTEYLLPFKNDNDIKNIINLSLLKVFKHIIPLYKIRTSNEKVKLNKEQKNLMEYDKKLLNVYIFYLKSVFCKNTFESYKCACEILNELDHFNFLEKSVNKVLIGTISEHEEIKEMCLDSIKNKLEGNNEETIFVIINQMYNLKFSSSGFEFLLNIKYLEDKKISDLQLEENGKKDIKMEKKNKKMEFLQRKNEKKKTNEIFLKNLENNKNKMSICDKKREKSRRLNERIIDEVENSENIDSKRKTLKKIVDALLRLYFRVLYDKKTNFYLLTFDGLIKYKRFISQSFLEGLFLMLNNLEIQNNSKLEINKLLCIQSIFENRNYDFKKSVSIIYKILKPLEMDIDRNNLEKLKIIVINLFINMKQPINRVNAILHRLIQFCLIKRVDLFHDLIFILKNNYSVNFSDFDQINANNYSEEDIDLVSEKAFFEFHTFLKVANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR5</accession>
    <name>A0A4Q9LTR5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0944p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000944">
        <property type="protein sequence ID" value="TBU11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0944p0030"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="23889" checksum="019EC853EAF5F079" modified="2019-07-31" version="1">MKSSLRGPERALIHGFNLISAFCDRSNITKTVMDRAKFIFKTVEEKKILKGKNTESVVAACIYIACRQENCARTFKEVSVLTAVPKKEVGRSYKLIFPHVDKMAVVSTEDIVARFCSDLNLGIELQKVAVKISRGAQQSGCIAGKSPDSVAAAVIYMVTHLFSNQRKVQKDIQHVTNVTDVTIKNTYKELLPYKYEIIPEGLVSKYQIDSLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ1</accession>
    <name>A0A4Q9LTZ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1101p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="PITK01001101">
        <property type="protein sequence ID" value="TBU11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1101p0010"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="400"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="544" mass="61957" checksum="742639C89D0C1690" modified="2019-07-31" version="1" fragment="single">RNESINRMKSKEFDLLIVGGGASGSGCALDAVTRGLSVALVDAGDFGCETSSKSTKLLHGGIRYLEKAMKYFDLSQFKLVFEALHERKHIINIAPYLANKLPIMLPVYNKIMVPYFWVGLKLYDWLSGTKSIGSSYFIGKSKTIEIFPRIKKDNLSGSVIYYDGQMDDSRLNLMLALTSSYHGAVISNYVEVKNILKENNISVGATCTDKITGETFKIKSKGIINTTGPFTDSIRKDTNKELRNIVVPSSGTHIVLPKEFGPKNMGFVFPQTSDGRILFFIPWKNKLIAGTTDNKCSVESNPKPSNDEINFLIDETKHLISYPDDLEKNTILSAWKGIRPLVKDPSKKNTESLARNHIIEVTNKRTITLSGGKWTTYRRMAEDAINKAIKTFKLNTKQPCVTKFIPLLGSHTYNHEMLYRIQRDLKVPLKVAKNWVSNYGDRAYKLRDYIKSDKINKISSIYDITEEDVEYTIDNEMAIKISDFILRRYRIGFIDVKEAYYMIDKVSKIMKRKFCWSHKQELVERKEAVESLKSLGLEFCMKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU80</accession>
    <name>A0A4Q9LU80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1790p0010</name>
        <name evidence="2" type="ORF">CWI38_1052p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001790">
        <property type="protein sequence ID" value="TBT98363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001052">
        <property type="protein sequence ID" value="TBU11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1790p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1052p0020"/>
    <dbReference type="OrthoDB" id="2199106at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="226" mass="26602" checksum="FA2D178A7552175C" modified="2019-07-31" version="1">MIFDIILVSIIIGVTIYLTRKSKEKMASLLPKFDSLDKYFKKKIDQPVSIYQHLLFYSGNNSISNMAAILTLKKEFCPFYYILSNSDFNFILTGTISAKTNIFIVSKKINFKHLGMKYAKKSKTCIDGYKMYYSGFTSVLQIKDNYMINFCSKYPIDIFYLSYLPEKYSKVNNYESKFYLKSNIENIFKKTFFDDFLNVLSQICDTKWNLKTYEENIKAFDKKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF7</accession>
    <name>A0A4Q9LUF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0820p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000820">
        <property type="protein sequence ID" value="TBU12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0820p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21816" checksum="47B773D8B6EC5D68" modified="2019-07-31" version="1">MLSFFKGIDKIYVAFFSNTDEIIEKICQTSALKNIKILNIIYSKFTTKDEIIFLKKYNIEKINYIILPNAPKTYFHNSAIYSPVHDLYLTSIYEISENNKKVFAYKNRKINKNIRKNLILVCHHNESMIEKVENSNSLSSMFLCVKLYNENFWFGFFALNLKEIKNIDVRFADTYIKDFEINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI2</accession>
    <name>A0A4Q9LUI2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0995p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000995">
        <property type="protein sequence ID" value="TBU11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0995p0010"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="54385" checksum="64415E3986820B31" modified="2019-07-31" version="1">MVQSDLHTWLKAAAENKITTKNTWKSNIIEYLADVNQFIENNGLNFQMASSTLDGAVKEFSTRVDDVSENTNKLLEHLDDEIDSDGKDNTKNRQRSKRQNFIEKDVENLNIKLSEQINQTKLFKISCRKTAHRLLLDYIFISSHGIQNLSLDENIFHENVILETKEYPLNLEECDFPICPSIKDIQNHSVKRISTHYTGLENREDLIENKDENENFENDFQNDFSTEFNNDFNESISETNNPPLITSSNSLNAWAGPEHWKSSISKKTKARKPTQKNLLNFSIKISTNILEKANTIFDASYISRRREDKPLLPNDYKINTEDIYKYAIREGSFYTNNNLEINDTSICGNITTNTEITAVSFIKEDLKEEIVVDIPPTERKDIIENLISKYNRTQKKVDIKKLKYKVYFNVEKNKIARLSDIYSEIKDSYDEIEKKDISVHYCIISLLHLASENCIDIQSGDNDILVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM5</accession>
    <name>A0A4Q9LUM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0922p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000922">
        <property type="protein sequence ID" value="TBU12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0922p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="396" mass="47750" checksum="95F61B7AD6FC4926" modified="2019-07-31" version="1" fragment="single">MNEVIQILPKKDENYREKMWKEIKIFIKLHSTDKNNYIYGIHTLLQNISLQNDSSYFYKKIIKYLKRLIKIQNITLKNISTDGLNYCKFLEQIIIFDNISQKYLNILLNLFSSVNFDIYKMKMEGNHFYRYRNKNVFEYKHSKIYKKYLKLHIDSINISLKELVKSYKQNKSIDTTVLSNTFKILQNNHFFRKSFYIIKKYLVRKYVCELRSILKTEVSNETLKRFLGANSRFTYNSAKENIGAFYVEQVNKLLFIERKTSYLSDVFHIIEKSALKKLFSESVFTEKYFKNIVNTPELQTLNNILFNVNLQDNFIERLKNFFKNEILRIKNYQDFFIVFYEMNILYLKMIENGVGSNENIKKILDECIDNFISEKQSVTILGTIWYLNQFVIKFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY0</accession>
    <name>A0A4Q9LUY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit alpha of translation initiation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1269p0010</name>
        <name evidence="6" type="ORF">CWI38_1213p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001269">
        <property type="protein sequence ID" value="TBT99643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001213">
        <property type="protein sequence ID" value="TBU11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1269p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1213p0010"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT99643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="296" mass="33843" checksum="2FFCA67118DE15F1" modified="2019-07-31" version="1">MVNYSCRFYENEYPNIGEIVVGRITKVTDLGVYLDLLEYNNLEGLIVIGELTKKRIRNIQQHVKIGKIDVGFVIRVDKDKRYIDLSRKKVTKEDQDMCLKKYAINKISHNVMVLVAKKTNVQLLKLYEDFGWKKVQEHGTLYNYFSKIMNNIENVENNEFGKILFECIKMKFTVSKVKVRADIDVTCAASGGITAIKDALTSVKNVYPKIELHLIKPPTFSIIINTDDKEKGINIIKSACNLISENIRKLGGTFAVSNEAKVYGEKNRIDLLVKEMNDLAEYNDSEEDSNADKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV21</accession>
    <name>A0A4Q9LV21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0846p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000846">
        <property type="protein sequence ID" value="TBU12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0846p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7469" checksum="A5A3CED43068F6B2" modified="2019-07-31" version="1">MHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC1</accession>
    <name>A0A4Q9LVC1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0847p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000847">
        <property type="protein sequence ID" value="TBU12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0847p0030"/>
    <dbReference type="OrthoDB" id="2233964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54909" checksum="E6E5ACC01025CBB8" modified="2019-07-31" version="1">MEPVSRKENNNIEKLNCDFLRSHIFLSSVLIKHEKQKNNKIKAANDADEVNKSETNFIPSSFYIITTHPPPGQTCSKCKKPSYDMTNPYIIRFCNNLLKRMASDCFFAENEKGQEENGERRIIATCLTEPCTLIDTTEYINLRDKFLEIGKVVVRTRKLPTMDLINRVVGEYVGAHVPESITESAYIMQAAQICYDEATRKEKPRSAWKENIGSKISKLVLSKDLLEKARKQEKLSTSETKSLKKIRREFNLNLSSVTDLSEALVKKNESLNVYEKKITMYKSRKHFRKENRMFELFQGRFYRGLSERVESEHVVSREEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYLYDIVKVICLEGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTKSVRGLLAENQLGAVRGVQGAKEQTLLNIALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE1</accession>
    <name>A0A4Q9LVE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0838p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000838">
        <property type="protein sequence ID" value="TBU12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0838p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="5720" checksum="3581758EFA05BFEE" modified="2019-07-31" version="1">MIGFDCAKNSKPKNKAPLISQGGTTLEEPTNNINKESDLEEETKSVKEVENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG7</accession>
    <name>A0A4Q9LVG7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0668p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000668">
        <property type="protein sequence ID" value="TBU12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0668p0030"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30810" checksum="4CA389E2FFE5A870" modified="2019-07-31" version="1">MSQHCNQSRKKVDHLVTRCEKMLGHDYTRRHNELDRCIHLLLLNKYKLKSSKRIRGHTIRVDTRIKTDVKIRCNRPDIFILVKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLTNELGLIYKCSFEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTESWERASLSVILSAEIHKQPTLPLKQVDNEDNGVKTENTKNILSLILDGITTAKEPTTNTNKELEVEEEIEVVEIMERIIWKEKNLLTQKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI0</accession>
    <name>A0A4Q9LVI0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1098p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001098">
        <property type="protein sequence ID" value="TBU11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1098p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14917" checksum="70A58C50686AC84F" modified="2019-07-31" version="1">MELNELDKNDWLDFKNENLEIKKKDLNRNKTVVEQKNLYGFTVNTFKEYKRYLRRRLIRNKISKNGCVTIIDKEFTKLDSFMSWINFIIGFLIFFTFKSVRNITFSVKNIYLYIIKRYSCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP5</accession>
    <name>A0A4Q9LVP5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1004p0040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001004">
        <property type="protein sequence ID" value="TBU11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1004p0040"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="30708" checksum="0F58827C25DE129E" modified="2019-07-31" version="1" fragment="single">FGKCNCKIQKKEKSVIVDGKETFIGDFRSPSEIPWNKYNVDGVIEASGVFISLKDCEGHLKSGAKKVIITAPSKDAPMYVYGVNEKEYKNEKIISNASCTTNCLAPLAKLINDKFGIIEGLMTTVHAATATQKVVDGASKKDFRSGRGVMQNIIPASTGAAKAVGSVIPSLNGKLTGMAIRVPVSNVSIVDLTVKTEKPTSLEEIKELIKKESEGELKGIMGITEDEVVSSDFNGDSRSSIFDYKASIALTPTFFKLLCWYDNEYGYSYRVVDMLEYVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW79</accession>
    <name>A0A4Q9LW79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0903p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000903">
        <property type="protein sequence ID" value="TBU12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0903p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20882" checksum="8973B8275F9C6A10" modified="2019-07-31" version="1">MWNSNVNIEKSSTEKLISFVNIIILKNELKSILNHSSKTYFIFMKNIIRIRNNEISGLDAVTSYNVMCILLRTAKYKLDILNNFLRPNYAINYAINYAYKRKLNSNTEILFVNVKDIPSAFLNREMVLFEMIVEFRRKVTEESQYKLINILNEIIKNWYQTIQYDYRTLKKLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD7</accession>
    <name>A0A4Q9LWD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0548p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000548">
        <property type="protein sequence ID" value="TBU13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0548p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="593" mass="69476" checksum="D3E0743251B821FD" modified="2019-07-31" version="1" fragment="single">MDKINDDDIYCKFYKKEVIHKKVTTITRSIIFNIFDIFLIFLLHLLLLNESACLQIEISFLNEVENSTVNCNKAFDNLDIFCEAHPSDKRASKMQPKLNFQDLSDDTPALTTHLHEKDLIVASVTNPNDSEISSKKRRHDLILLKSNIITDAQCDSLNHCQNNEESISGSEEMKPIELYSNKKRKISDLIEFENSEWIVKTNTTITFDYSNKFLIQSKYFNKYIASELNHVKYNVTEITKTNVDITTFEIFLFIIRFGYHKKCLEIKFDGFITLLELFYDLLCYAESNVICKVYNHLIPCLIIYKNDISSKIDTLTLENKFLIQKSLFLPFLHTFFEYVDVRFDKNTNILSFSKRESQINFYLFEKKIIDEIYIRTTPEVINILETESDDELILFYWLISLFKIIGIKISNDNIYYSESKERDRICKYENSALAFPSPNLKLLYSHILESIILHNNNNEIKFLELERVNISEGFLNFIKILCKIESLILYTCKLPAYSNFLCHLNFCFPKLKTLKVNTLILTAAFFKSLRNLKIEYLDLSWSTFDGNYTKVLELYDGFYTLCDLKLDNSRLGYKVISFLLKSNALESLSSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG2</accession>
    <name>A0A4Q9LWG2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0343p0010</name>
        <name evidence="14" type="ORF">CWI38_0538p0020</name>
        <name evidence="13" type="ORF">CWI38_0539p0020</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000343">
        <property type="protein sequence ID" value="TBU03168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000539">
        <property type="protein sequence ID" value="TBU13073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000538">
        <property type="protein sequence ID" value="TBU13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0343p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0538p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0539p0020"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000049">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="41"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU03168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="447" mass="50823" checksum="398FBE0E4DE75EC7" modified="2019-07-31" version="1">MREIITIQVGQCGNQIGHEFWKKISNEHKIDLDDNECNDKKSTFFYQSDSGRYIPRCVLIDLEPRVVNSLTESALFNHENIYLSNEGGGAGNNWAHGYSSGNKSKSTVLDIIQREAENSDSFESFLLFHSTAGGTGSGFGSLLLEELKDNFPKKNLSTYSIFPNQDEGSDVVVQPYNTVLTMERLIKHSNMSILMENGSLQRAMGESIMDRHSEKRMSSSFQESKIDESVKNNTPFLFSSFSHINTLIATVISESTSTLRFPTYLYSDHRSIINTLCPLPSLNFVIPSFTPFIVEDYFKISRKTSCLDVMSRLLMEKYRMIGTNGSIISSLNILSNVCPLEVQRGFIRVMERNSVNFVPWKIPGYHVVISGQNKKNICGLGLNNITGIASYFRKITNQYDKLRKKNAFIDIYRKFNEDLNIFDQARETVENAIQEYEKSELSSYINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ4</accession>
    <name>A0A4Q9LWJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0673p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000673">
        <property type="protein sequence ID" value="TBU12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0673p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="8493" checksum="0E67FD5BB8C929C2" modified="2019-07-31" version="1">MFVKGVGVSGRYYKGGVSYMFVKGVGSSSMFGSKGVLSIEGSVSYNSSVVKGYRIVRGVKYTYYNYFSSILLLGVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT9</accession>
    <name>A0A4Q9LWT9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0856p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000856">
        <property type="protein sequence ID" value="TBU12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0856p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="38880" checksum="9607A5ED0EB62493" modified="2019-07-31" version="1">MEIELIKYLFDKENGIEYDKYIFEDIEISGLKFDIFPNLDIKNSTQEIFLCRHITTSDFEIFYRFIISYYFLYEKMTIESFYTILYFLEYLRVQYDSKLRKNDVVDKIQLHFSKQKIFSHAYFKIISQEYFKEFKHENNFEPWIFIKEKNFVLFEKYESLYTANRKYLLLLKGNFFEKFSKKITRNVKRKNLFIILLNTFDLKYLDIHDLESKYLKICCFILDNLKKTLDEIVFYNICVRDKLIISLNTNQTFIHLKKIVFLKSKIKTKLKFSNNLNKIEEFIFNDSCIINKQNSISEYQILERLEDIKNIIINSQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV1</accession>
    <name>A0A4Q9LWV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0805p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000805">
        <property type="protein sequence ID" value="TBU12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0805p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="282" mass="31165" checksum="EBE0CDCEE7C5E820" modified="2019-07-31" version="1" fragment="single">MNRPINSNSSLPFILSYDHNTSLTHLNLTPNEHTTGNNSKILTNTTGSYYTSKDIKGSYTQYNTGNTTKGSYNTSNSTKGSYTPYNSTKGSYTSYNSTKGSYTPSNATKGSYIPYNSTKGSYTPYSTTNSTAAYTPYNTVNTSNSTTGSYYIPYSSKNKESSKIPKINSSGVNNTLPIISNELSFKIKPFNDKEKKYIIKGSKYTFDKNNTNNNNSPHLKTLQSQLTNFLSRSDIPYYSSEIKVLSNKIDTLYNIVSKLSEIKKIDDKASSLMKIGSVKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX5</accession>
    <name>A0A4Q9LWX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0484p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000484">
        <property type="protein sequence ID" value="TBU13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0484p0060"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="489" mass="56984" checksum="A91B402C83D55C63" modified="2019-07-31" version="1">MSVSYFHTYKSHIKGRWLNKPLQEALSSEFTHRPPSYYTNAIISQAITINDQPTNPDKILSSNDILYHTVHIHEPLPKQLKIIKIESEYLVLEKPFGVPCHPTTEYFHCSVSQSLKQFVYFEIFNNSEFLNKEFQSFNEKRNYLIDKNKNKTNDSESSTDNTNQNLYMKENYLIETNENNIKNSFSSTDNTNQNFNDKENYSINTKDIKTNDSFASTDNTNQNFNDKENYSINTKDINTNNSESLMNETDHIFLEKKDIKINNSESSINNTNQKFLEKDFPLLLNFNFATFNPKITLSCINRLDLPVSGILIIAFLNSQKYHKIIKNSSTKKFYVALVKGNFPNKISVNKKLKFVKGKKSFVDEQGKESFTDFYCLKRNKEYSLIECMPVTGRPHQIRAHLSSIGFPIINDIKYGYHQIPNESNEISFGCFTPLDHTQTHSKYRFAINNCKGIKSKSFRNYNEYICLHAYKYVFNGNTYECELPEWANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX25</accession>
    <name>A0A4Q9LX25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0840p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000840">
        <property type="protein sequence ID" value="TBU12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0840p0010"/>
    <dbReference type="OrthoDB" id="2195336at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7624" checksum="1A68CDA4A1897980" modified="2019-07-31" version="1" fragment="single">QHNNIYSNKSKLALGDMVYVKKYLSTKLDKKYVGRKKVVWISKKGYWVRLDGDKHFTHIKNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX41</accession>
    <name>A0A4Q9LX41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rcd1-like cell differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0811p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000811">
        <property type="protein sequence ID" value="TBU12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX41"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0811p0040"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="21961" checksum="7D69533D9ED572E0" modified="2019-07-31" version="1">MQRILYCKDIRNSMFETHMPFYLYPFLNLSDNTQKYECLRIASLGVIGSLLQDDSEVAVNYLKNTELIPLTLRIMDIGSEVSKVVATHIFLKIINNKEGLEYACQTFERFVAISVILNSMVYQCISIPSIRLLKGVLECYIRLTFKGNVKVSLFSKKPEALMHTEIQKQIDSNPECKELFNRFMDIIASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF0</accession>
    <name>A0A4Q9LXF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0452p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000452">
        <property type="protein sequence ID" value="TBU13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0452p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="33323" checksum="25FB454E1E1314F8" modified="2019-07-31" version="1">MFIYNSIERDIIFNVVNENEESYIALINNELKLECLCQIKREVTIDTDEKNCLERMLVRNSKRQHELYNMEFIKRFGLKFDIFEKFNKINNNVEIFLCHHIKKSDFLIFYEYTLDEIKELDLNIAKFIVQSLKHTYQQYSIEEPIKENEKIPKENGNFHLKLIKEDNFKGKIRIIEYLECKNNNLQVKCFYEYKRFFYNRKYYLEENIESIKIPSSEIKSDFLRDILNIKGLESLEINHLNIYIENEIFLNESIKYFKFWLNNDNDCYSIFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM7</accession>
    <name>A0A4Q9LXM7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0684p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000684">
        <property type="protein sequence ID" value="TBU12641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0684p0010"/>
    <dbReference type="OrthoDB" id="2196113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21748" checksum="89F61F1F5C22E9E2" modified="2019-07-31" version="1">MLHFLYFIFSTIYCLEDDHGFVLKSIERLQNKTNFKTFYEMFGVSENASFRSIRKRYAKMMRNENPFPKLKMSKFEADHILTEGFNILKTKRIFYDEILNNAIFSKPIKESKRFTMISGILMGIIFLIVSDFFILILKENMKSNRKLTKKEKRIERISNKPDFADLYLLKSYNKIRNFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU9</accession>
    <name>A0A4Q9LXU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0715p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000715">
        <property type="protein sequence ID" value="TBU12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0715p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020683912" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="13750" checksum="BD7841517175AFBC" modified="2019-07-31" version="1">MGTILLTLLIIQFGLLSDRKKTRGITKIFDNTRNQSATSIRKRPSTNSEDTIVKNFETLNTNLNILLCLSQVSNSKKNEYCKEEYAIFSLAKIRLAKFLKYKALMVVNLIYTKNNKSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY52</accession>
    <name>A0A4Q9LY52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0675p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000675">
        <property type="protein sequence ID" value="TBU12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0675p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="27060" checksum="5B22CE8F4EB47A36" modified="2019-07-31" version="1">MTNINITDITEVNLLVLHTVLTMSQPKIKSEEDRERQGIVLSCIGFVLVKSKKKFEDENRKSSDPNTKTDERKITEIVLFKGIIEKPMDEKALLLRLESADFSKLGNTFREVLIKHKSASILRIEHRRNLHNLLDCAGENKELYARRSIRPKMGNSNKIHLAQIKGFLKPKYKSEEKPRRKVWEAQPIEIYSEIENTKAPLKVILSRKNELLFEPSNKPMFCYDDIYHSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY55</accession>
    <name>A0A4Q9LY55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0493p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000493">
        <property type="protein sequence ID" value="TBU13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0493p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17615" checksum="41A526776099F62F" modified="2019-07-31" version="1" fragment="single">MGTTRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY60</accession>
    <name>A0A4Q9LY60_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0671p0020</name>
        <name evidence="9" type="ORF">CWI38_0851p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000851">
        <property type="protein sequence ID" value="TBU12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000671">
        <property type="protein sequence ID" value="TBU12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY60"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0671p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0851p0020"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23697" checksum="8644FCCDC5903432" modified="2019-07-31" version="1" fragment="single">MGILNSRVLCEEEIEDLLATTVFTKQEINILFQRFRMLNRSQQNYITFNELMLIPEFHSNPLSGLILSAIENYIQYENMTFAYFLDFMQLFSHKTDKKERIKFIFSAFDINKDKKICKDVLLNIYTLMNGNSNICIEQAEASVYRVLSLYDRGNKGYLSYKDFIRFYTSDPSLDKAMVIDFSREIERYPKFGFRQFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA5</accession>
    <name>A0A4Q9LYA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0455p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000455">
        <property type="protein sequence ID" value="TBU13366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0455p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13152" checksum="BE37FF17B662968A" modified="2019-07-31" version="1">MKITKNKVLIGALILICFIAGFSAIEFFGSKKKSPKISKTKNDQNSTIPKTRTKRPECSKTEEDNLFSEILRNTENVPNQNEIQEVRLRYHGINEKARNLSIKIMNIIRMMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC2</accession>
    <name>A0A4Q9LYC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0584p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000584">
        <property type="protein sequence ID" value="TBU12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0584p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="268" mass="32472" checksum="5CD457DCA68367D6" modified="2019-07-31" version="1">MKIKIALFHVFFGMSSIIILVIFTLYHEYLEKENKIRTCIQKGLNGIHISEFEEQFEIFKEIRKNEIFLIIKFKDRFYVNKKAKNSSIYMSQINFKRILGSMVESENLNLPTKMIYRDRLVNSFTKISFVRKYLLDKNNFTRLFSYSENETHNRKRIRKFLLNAFNKFNKNLYYINKYIEFKTNFKRILDLTQEIPFDHNFISIFGQKDILNISCIIFYPNKITIYLPEINSDIDFITFQKIKVEVERQDFDNFHSSIFFYLMSTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL7</accession>
    <name>A0A4Q9LYL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0312p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000312">
        <property type="protein sequence ID" value="TBU15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0312p0020"/>
    <dbReference type="OrthoDB" id="7978815at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="22342" checksum="AFE4778F36F340A0" modified="2019-07-31" version="1">MGGIKRSGMHKETNPPLKQASNDNNCAKHAKTKNYRPFFRRRTSLDEPTININDESNLEDERFKTLNDLKQDDVLACQLFNLSLEKVVRDSANSNPSTPDYIDLIARSEASLQRAKKKVMLYETLLRPILMYRSEFSVLKNIDEQRVAETPQQGILHRIEEYVSIGLNLPEQTPLGFEPYTSLKMESGKAQDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD7</accession>
    <name>A0A4Q9LZD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA topoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0523p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000523">
        <property type="protein sequence ID" value="TBU13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0523p0040"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680:SF1">
        <property type="entry name" value="OS05G0489500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680">
        <property type="entry name" value="OS07G0190500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21781" checksum="B8978B367E66433E" modified="2019-07-31" version="1" fragment="single">KNDFSYFNRNNENTTNNGSKENYNVNFKNRNEKTRLSNFNNENEKNTKKYLNIRDNNDDKNEVLCHCGIICKISKVKKGKNVDKDFFSCEKWPNGCDFFQWCDDKSDETKRKKVQKNSYQQKYSSNSKNTEYTNTCQSKTDVLCHCGYETKSVKAKTKQNSGREFLCCKKLHKPCKFFAWKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK8</accession>
    <name>A0A4Q9LZK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small Ras GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1767p0020</name>
        <name evidence="5" type="ORF">CWI37_2070p0020</name>
        <name evidence="7" type="ORF">CWI38_0453p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002070">
        <property type="protein sequence ID" value="TBT97794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01001767">
        <property type="protein sequence ID" value="TBT98405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000453">
        <property type="protein sequence ID" value="TBU13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1767p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2070p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0453p0020"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT97794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT98405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="203" mass="23576" checksum="AA3019D42541B890" modified="2019-07-31" version="1">MDPEYKYLFKVILIGDSGVGKTCLINRYTDNVYHTNYISTIGVDFKIKTLKIANEVSKLQIWDTAGQERFRTITSSYYRGAHGIIIVFDMTDLQSFKNVKDWLFEIRRHASEDVEIIVLGNKVDLKDFLKVTREDVNIMLKNNNLKEECFWEVSAKENIAVQNVFEKLTQILIEKNKKIGYSKDIDKELIDLTSNTERGSRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR6</accession>
    <name>A0A4Q9LZR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0433p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000433">
        <property type="protein sequence ID" value="TBU13431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0433p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="21342" checksum="37D8FAC407B951C1" modified="2019-07-31" version="1" fragment="single">KKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHKEPIPPLKEAKTEEDGAKNYKPKYKAPFILQGGTTLEEPTNNINEASDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX0</accession>
    <name>A0A4Q9LZX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0183p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000183">
        <property type="protein sequence ID" value="TBU19869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0183p0040"/>
    <dbReference type="OrthoDB" id="2188018at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="194"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="47213" checksum="8E0053F652B8160E" modified="2019-07-31" version="1">MIGKIKNSGNIKKINISEVTKNQGLESSELIGILNKIDECKQDSNDMGNIHKSIFRIIKNSKLKEKEEKNIKTKEDLEKANLSFLENVAVKVHEINIWNHEDKRFLTLKYHMEYKFPIMIYKKNEIYFKSKLIYEPSREKKQKIPFNKLENKETKAEDTVKYDLLSDKEKIKLACFCFKKLRKYRSSFKDNILEKISDIFRSSFKKDSYHMKKANTFVYTVGDHIMDEGIKKEGLFRISGKYTYYKLMPGVLAAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQVAERVMKIIKNQTDPSIIEYIVPLIIFSITNENRKMLIYLQKIFRKVNQYSKDNKMGSDNLYKIFTPTIFPNIECYDLQSINLQIEIVKRIFESNLIEIPCFLYEEGLSVAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M000</accession>
    <name>A0A4Q9M000_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0271p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000271">
        <property type="protein sequence ID" value="TBU17664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0271p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="30867" checksum="5C8445CE046AB029" modified="2019-07-31" version="1">MKKNIKYDDDLDNIFVSFSEEEKSSSFMNIFSVFCTRTAEIQMNSKKAKTNLKFLAFMFFTDKFKIFQFEFFFSKDILYFHEGFSNKIASEFLDICAPIFVMRITHISFIDLQNFFPEFLSNVSKQFINSANKFCLGKIIQEESESISDHTKYLIGNIPQNCHLWLGFLHELNSAYEKTNEFQGRLMIIAFEISLDSFREIYNAFLNEMNENNEMFLIHPEEMKACRDFFFKCILFRIKCLTEKFNVENISSIELEIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M066</accession>
    <name>A0A4Q9M066_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0156p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000156">
        <property type="protein sequence ID" value="TBU20000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M066"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M066"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0156p0040"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="25552" checksum="E4A1388716AD8CCF" modified="2019-07-31" version="1">MARPRSHKRSKNPKRPYDRDRLLEEMKLVGMFGLKNKRELWTIQKICDDIKRRARDLLISNDEKQQIVDGRCLLNKIVKIGIFEDVDFRDRSDIVKNLEKVLNLTPVNFLERRLQHRVFEAGLSKSVHQARVMINQRHISIKGRITDKPGYIVSAENEGFIEIAPFSSLGGNKLSKRKKKNRGHTGHQEDNHSEGTVKNINEDSYLEEDNEVVKMVEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A2</accession>
    <name>A0A4Q9M0A2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0244p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000244">
        <property type="protein sequence ID" value="TBU18376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0244p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18468" checksum="FE5EE3A89183600A" modified="2019-07-31" version="1">MSNSFPSQNTNKKKYRFHIRETPERIERENENGLECLVITSESRLTLEIKESLQTFVDLEWSKTQHDTFNVDVPTSKIDRTLGIPITLQNVFRELEVDNKDKDFYPGLNDDEEIASYRIKYLLPYSPFLNPIGNMIPGGARTEPQLRILICEKFNEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K6</accession>
    <name>A0A4Q9M0K6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0129p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0010"/>
    <dbReference type="OrthoDB" id="2190279at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28876" checksum="499A2A5696D4BB6C" modified="2019-07-31" version="1" fragment="single">SFYRKNFIFFQISPYKEIKSIVYLEEFKNYTFFNDKICVLKDNSVEHLDGEKMLEGDFSQFTDIYMINDNIVLSGNKYLKIFEICRNNSENEKKVFSVENIHSYFIKCDCFFIGYAVTLIGRKNLIDIKKENQLLGTLTFPENITSVISDTLVTKVYSGSESGKIYFSSLEDNNCLEHILYFHESSIIQLKMSFCEKFLYSLDSNGKIAVWNTEYNNFLGFNNFEAESMLVCCENEVGDFQNEDFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M4</accession>
    <name>A0A4Q9M0M4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0119p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16687" checksum="AC6C86A6F75B3CEE" modified="2019-07-31" version="1">MDKIFELEKLETLKINNCYVHNFHSDDLICFSSRNLKYLDLEDKSVDLSDNSHFLSELNCLEYLRVSHSILPLDHLIDLNRKSHLTLKALIYEHIRLNVWDLMGIEKLEVLEKLSFQYCTFLDTDSYNFKNYYKFFHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W4</accession>
    <name>A0A4Q9M0W4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0096p0060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="PITK01000096">
        <property type="protein sequence ID" value="TBU20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0W4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0096p0060"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="236"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="679" mass="78273" checksum="9501C959A2A68E1D" modified="2019-07-31" version="1">MNIKDLSLHKPIKRALKENKIENLTEIQQLTIPAAMSGKDILGISKTGSGKTLCFVIPLLQRLVDNKWCMEDGLGGLIITPTRELAVQIFNVLKKIGKNCYLSCGLIIGGIESKGEKEVIGKMNILVCTPGRLLHHILETPYFDISNVQILVIDETDKLLEMGFKKDILEIMSYLPVKRQNIFLSATPKSINQKNLIIDFDSIEIFSAYKNENTNENKKVKNNLEHFFYVLSICDKVEYLYTILKNNNSKKIIVFFSTCKEAKFYFLVFSKLKMRCKFYLLNGSIKQEKRMEVYDSFKREKSGILFCTDVVSRGLDFPGVDVVIQYDCPECVETYVHRAGRTGRFDKEGISILFLLKSEKGIIQDINKGKWKEGSKERGTEGKKGNLGEECVSEGKKGSVSGCKEGNVSERSVSEDRKGSVSGCKEGNVSERSVIEGKKGSVSEGKKGSLSEGKEVKSKKNKEDSNDKIIYEGKKLEIKKIQNQIKSLIAEHEEIKIFAEKYIKTFYRFIEMNSKKYLEGTKEQICKLKEYFGFEDFSDESEEEFENIRNTKESDNKREDNKGDRECSKEKHKGNIIRQDDKENEERENSKENYKRDMERENIYKRNKKSQIINNSKRNEEFKNIEYLNSDRKINKKRLVGKVKNTKIIFDENGNEEEFYRDEITKKEIEEGLEKKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z8</accession>
    <name>A0A4Q9M0Z8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0091p0030</name>
        <name evidence="2" type="ORF">CWI38_0261p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17184" checksum="07B310A66F15639E" modified="2019-07-31" version="1">MSHSVHEILNNEYAEIRERYILDKRQNRITLIEVIITSQDFLQIVETEKLRKYDFLANLLGLIMFDSAKKTAETISFDQKEDSNLDQIPKRSGREDGGKTENTKNGRIIISDGTTTVVKDPTINANEDSVLEEGSEGLKCLKESFNSEKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M108</accession>
    <name>A0A4Q9M108_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0608p0010</name>
        <name evidence="7" type="ORF">CWI38_0309p0040</name>
        <name evidence="6" type="ORF">CWI38_0703p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PITJ01000608">
        <property type="protein sequence ID" value="TBU01877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000703">
        <property type="protein sequence ID" value="TBU12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000309">
        <property type="protein sequence ID" value="TBU15686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M108"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M108"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0608p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0309p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0703p0040"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF42">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU15686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="243" mass="29207" checksum="3CA80FAC6012AB27" modified="2019-07-31" version="1">MKKIILVHWRNVKLPEKINYMENIEEEAFENIECYMTVPLTHLLLARETFPKFIRLVAPDCIEFDENNEYCSGITIRNLLDIQIKTVILGSAERIFDMNETQNIISQKLICCYKNKLKVILYLINTKEEYETDMEAYNLLVQLTKYFSTLQQNLWNEITVIYEPEWFFIQDYSYFELRLKNKVAYIKKALDIYLITAKIIFSGRLNYIFIKKMLEKKIVDGYLYHGEPFDDDFMNIIRFMNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M195</accession>
    <name>A0A4Q9M195_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly factor NUBPL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0065p0060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M195"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M195"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0060"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="372" mass="42042" checksum="599EE5837A5EA6FF" modified="2019-07-31" version="1">MSIPTDCSLKGCDSCPKRSICTSKVEKTEIKNKIKENMKNVKFSMAVMSGKGGVGKSTVCRGICGELVSKGYVVFVVDMDISSPSVPRIIGSLDLIGNNYFKDKNINTDRGIESNTNRDNIIDRDIDNNTDRDIDRAFKDNNGIDRDIDNNNTDRDIDINTNPPLTPNTCTNKYTKDFKDNTVEAFEEMVITYDKIYPVKINENLFCISAGYIEDINYYNYDMKSMYVQKVLSNTVFIPDCIVIFDMPPGTTDEHLSLLECIEELPVIFVSMPSKICVSDVIRQIGLCKKMKCNILGIIENMNVIECKCCGKVLVSEKDNVVRMCEEQGIPYIGSIKYNQQICFESDRGNCVEDLLFVNATKYILNEIEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A2</accession>
    <name>A0A4Q9M1A2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0318p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000318">
        <property type="protein sequence ID" value="TBU14951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0318p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10287" checksum="DBE2EE57203961C6" modified="2019-07-31" version="1">MLSNECILPTIQKLKDLERKLRTRRINILNEISLLQKEEAKLISLKKYIEDSMIIDNTTNNKYVSIDDKDYCSLEKSNLYFIDDNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C7</accession>
    <name>A0A4Q9M1C7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0312p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000312">
        <property type="protein sequence ID" value="TBU15420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0312p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="552" mass="65452" checksum="CDB8C6EFBF6D35C9" modified="2019-07-31" version="1">MFLYYYVVNATGNYIFDALLVDPLVSDINNVSVQCECEYNTNVRDVLQKITPYCSNEYYERVMPKVEFYIRKVYKYFDQNMHGFILYYTCILCSLLGHGSKSNRNEGEGITCNIEFLFNILAACKLYELCKSNLIFYDFLAAMEEGLINVEINKITSGIFRTEYTVEEQKDLFRIIFNESIKFKSMNRVLYESKLDRFVLANSRDDSINKKILDHVSKSSFERLFSLIITLKYHLLFKNNTYTLEQPFFVYNFTLDDDLYQNLVKTSLWFPQELITQFDLQCQEILYNHIFDRTFKRLSSDVNIFEKVFRFAKERPDCYFNQPDLFFPEYILVLFVANDQFNKIISVYKFLAEIIDIKYHEYIKILVCIKSSCLIPKNISFEAYLRIIFEIIFLVDIVSQVYVENNIESKVLHQVQTINNNIRKTLENFQIRYNLDRNDSILVGKRITKAFIDIKLMLVTIFFLDYSSKRFLELKIRKFLDEKNIIRFNDSSDAMNDYIIYLVFKELDLTRHITVNASSSNKKFNLPDLICVLIILTVIGTVCGVIFYILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H0</accession>
    <name>A0A4Q9M1H0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0259p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000259">
        <property type="protein sequence ID" value="TBU18000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0259p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="496" mass="58280" checksum="961B64E84DE5C55F" modified="2019-07-31" version="1">MLRKGWTGTLKRYSAELEVKSEEDREQCRIVTCISDTCTLTNPTEYINPRDKSLSTRKDFLEKEIRKVLSTMDAEHIIQAEQENIEGKISKFFLYKDFLMMFNLNLSSIADLLETWIKKNDNSKNRIVCLGYSEIDFINDLLSSVADNHPMEFFFLHEFVGIVYWLLNLRAADFTTGKHIYFQTLKVHDKVVSNFFPLYGKAKRLTENQLDALKGVQNEKEQPLLKINLNKEYRKNESHLHICKTLKKFVEMSSLPLLVVLCIDSLSCKHNNNTQEQNKFQKIFLEVNHDKSDTIDRYWKVTAILSKNVSVYKYLEIEEDNSGNPTLSSFKEVQFKLISRAERLFRTILNQKIYFYAINQPTILLINYKIVAFWPELIDFSKLDGVADAVLEKNKLYIRQNINVYIFLDKLKRVSYKFDDKTHLAPIKGFLKVNIGWKKKSHSFQEVIKNECAEIRVGPTIKINEEFDLEEEKTVVQEQREMHKSVKIVLTRKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L0</accession>
    <name>A0A4Q9M1L0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0056p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000056">
        <property type="protein sequence ID" value="TBU20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0056p0030"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="200"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="381" mass="44021" checksum="122029F46655A9D8" modified="2019-07-31" version="1">MKGYMQNFSNRTFDAEKNAIYDFFSLEVFILRCTNKYDFHVGETPECTECENDNVVKCLVETSGSNDENLFITTIPTRRKQKVSINDQERIIEKILEGYSMSAIASIIVRRYLKTGLVFVEKIGAQDYKNPYELAEWVKCTFNVDVSISTIDRALREFHYTPKRVKLVPERRNTLSTIKLRTNYATSFRELEVDNDDKNFVFLDEVGFAVVTRPSRGRNMRGASAYLSVTAARSRNISVVAAMNKYGMIYHKIHERAVNGEDFKLSIKEINESCQRQGISIPIFVMDNARIHHYRGLNDDEEIASYRLKYLPPFSPFLNPIKNVFSVWKNKVIRGGARTEPQLRILICEKINEITGEHCSSFYRKMLGYLQKAEVGQVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P8</accession>
    <name>A0A4Q9M1P8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0180p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000180">
        <property type="protein sequence ID" value="TBU19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0180p0050"/>
    <dbReference type="OrthoDB" id="2191528at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="46673" checksum="82AEE1724E223F98" modified="2019-07-31" version="1">MNMWFSENSMSVSTPFLERALKKMENICTEKKQTIKERECCAIFLMSLIPLKDSFKKYKNIKLFVRGYQKNENYRMNNIEYAISAKFKGNEFIINEVSKTKQVSFSCYHETCMTIFIICNKIVKCFYCKYNGCKLVRGVPLFLYEVDLFVKNKFYQIASEPSFEIRVKTINLKATNTNMPLHYNMNNEIVEYVKKHNFTYKIDEFEFDMDEIKCVFCFRSYETLENLIFHINHFHLNYYAIQSQNCIIVTLSVDKTKYDVEFCFFSKNYKRKHTTRIFSRYCYEYFESETMEKLGTKKNAIKWWNYLSDKKIAELVDISPSKILLMQNWNNFISDKRIEAKEINYFTCIKEFVLKNEATEDILDFLYILAGKSVISLEELVSIVNEKVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q2</accession>
    <name>A0A4Q9M1Q2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase/endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0048p0060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1Q2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0060"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020612989" evidence="6">
        <location>
            <begin position="18"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="226"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="8">
        <location>
            <begin position="617"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="747" mass="88158" checksum="F9A3861F3CCC0C5E" modified="2019-07-31" version="1">MLLFVQLFACGLLIIETQDGFLHVLDKETMKVTTLLNINHIINEDSNQHTGLTYFTPNSSLNLTEYNNKYSKEENLNLEFENTKNILLKEDQEKVLPSHKKFIDSLFLDRNGYFFYKENGKLVSMNLSIVEIIESPKIVRNTVLVSDKNVTIHKIFINNIEIHVFIVNVTITAIDALSYYNRKIFFSYIYYPFTSVCEDLIFQRNSVFLKTKFQTVEFNSNIVGAYMIKKHYNNYYFSKIFTVSKMALPYIKSNRRSKLVYLLSFVVIVLTIIIFRSKRNVVNIKEIIADRKNYVVRKGFFDKTVVIVKVYKKGDIRSENEVNILRKNQSLNIVGYFYQEKRRWSTLIVTEYCKSLYDCNNFNCLRRLSCDILNGIMFLHSKNISHLNLSFQSVCIRNDGCGILTDFEDARYLDSNLSFLEHEIGSKNFRSNEIILFNHKIQNLNSQMAFKADIFGLGIILYFLITRRHPFDLNVNGIPLENMYFSDDEKSDSPSNETTGDQKNNKSLPNKKPDSPPYEDKVSNKKHKSKNKNLEKVESKNSTNEIKKINPIETSLCKNIIKDTENDFEMNILNDKYKLVYLNDHNLHDLVCHCLKLHYMDRPDIFNVGCHPYFWDNEKKFNFLANLSDILENKTEESKRVFLRLERNKRKVFNKSWILYLDKRIEEELNIFRNYNFSTLKGLLRAIRNKGRHYKELPSEIKQLYISFPEGYVDYYVKRFPSLLMTCYYSAKCISTEELLKDFYCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S4</accession>
    <name>A0A4Q9M1S4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 domain-containing subunit of coatomer complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0044p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1S4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0030"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="5">
        <location>
            <begin position="838"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="979" mass="110211" checksum="0E3D578FD9ED9E4C" modified="2019-07-31" version="1">MSLKKQIIKKIETPRIKSISTHPQKQIALATLYTGTVHIISTTTLSILHTIHVCDCPIRTSLFLETTDQFLLGTDEGKLILYNLNLKKEKEVKAHDDFIRKVLSPTSQFILSCSDDTLIKMFSPQLFLLSTFSGHKHFVMDICIYPKNTNKFLSSSLDNTIKVWTIGSVGGSVVGSVIGSNTYSSNTSSNTYTSNTYSSNTYNKTPSSNTSNNPSNNTSNNTSINPSNNTNKYPNNITNNITNNITNTTTNTLTYHTNGVNTLTFINSGNYLISSSDDLKTQITDFTTLTPIYSFNTSSPLTLIREYTNRPLFITLNENGEYSFYNNKTFKLEQSVNLLMGRLWDVGFKDDKIIIGSDQGIIFVRTGDECVYVRKCNRRVYSIVNQVVSIMKINIGCDVGDLGERDLRDGEREGIRDRERERDSNSNNNSNNNSNKDSNKDNNIRDKIRDNTTNNTNNIRDNTKDNTITTNTTNTTNKTTNNTNNIRDNTITTNTTNTITNKTTNNTNNIRDNTITTNTITNTITNNTTNTPNIAKEISTLDFLPSEFIISISGKLMCIVNVDEYHIYSCMGFRSRGSGKGNNFKFLSDSCYLVREGDFICFYENKEKVCVLDVKRYDSVVYVDRDVCICVGDMEGNSNSNKSNKSNKSNSKDKSNTDNYTNTTTNTNTSFINTTTNTTTTNTTTTAWLSCRDGVEVCRFPWVVEKCVVSGGRVYMYEGGVIRVYECSNVGDLVEQGVVGVNYEDIMVELGIGLMGVVSDFYGEGDDIFIVSGCGVYLVDVWGGKVNFIWVGNFNGKFVGVDREVIVSYDGGVKVCVVDWWFVEYKRGVLRGEFGVVKNGRENEVIVFLESVGCYEEALRLVSDKDKKFELLVLLGRLSEAEELCSNFLGYCRLGMEFMRVKKYEKARKYFMLGKEWSNAYLCDVFCEKSFKEEIGVEAEKEGIFNLAFLCFYGNGKYEKCCEMLKGTEYYDMFKGSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y2</accession>
    <name>A0A4Q9M1Y2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0123p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16666" checksum="CAF1CB3F63F86A83" modified="2019-07-31" version="1">MIIDNNTIYVQQNNAKPHFSDNDADIVALGSADDRNIKFKVQLANSPNLNVLGLGFFNSIQSLQHQASLHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNCYKIPLLSKGKLRREGRLLEKYVCSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C2</accession>
    <name>A0A4Q9M2C2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0011p0110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 14"/>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2C2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0110"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="413"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU20900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="457" mass="52136" checksum="E965C6DC05D8C472" modified="2019-07-31" version="1">MNKKTLEDIQLTNKRIFLRVDYNIPTTYINNTHQIQDTYRIISTIPTIKYILCRNPKLLVIGTHFGRPKGNFKKELSLNFLPPFLEQLLHLQVEFSQLSELENTLMDEKLDKNITENKIDNEGKSNNALERNVNDDKESDNEDLYKTKSCSSRANNNRIILLENLRFYMSEENEGENLEEYRKYFTKNFDITVVDAFGVLHRKVNSIQTPTRVCGLLLKKELEMLEYLKNFDLLIIGGSKVTDKVVFLKNIMKKCKKVYVVGKMCYVFIKVLSNNIINTNTSSEEEKDILSAKEVLQVADKFSVKVYLPKDFLVKEKKCRDSECSSNCKEGIDNKKECISYQYVERIEPEQQGVDIGMKSIDELCGLIRTSKSVFWNGPVGIYEEKKSSFGTERVVKEMEKIKESGGVSIVGGGDTVCAVGMFGDKENFSYVSTGGGALLKCLEGSEMPGLNSIEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F0</accession>
    <name>A0A4Q9M2F0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="27262" checksum="E5A75BFD16D4F7AE" modified="2019-07-31" version="1">MYSVCIVHIFILIKSKNIYNPYKNEKYHDNHNFNVLLESHSYIKLEKQIFHILENFKLLFDKFRKYNNIRDSKSNKKRILYIEKNINSFYRKSVEMNKKFEKNIFHLIETLKSKNTKILSKENNRLKCKSFNFLNYTKNRFLREIELKHKLFSNQEIKNIEIQIYHIYESYEKLSLYLTKELSNNNVDAVSFSWAILSRIIKCQEIIEYIAINDLHIHKKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K5</accession>
    <name>A0A4Q9M2K5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0009p0150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0150"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="71"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="31033" checksum="DDBBBC53C76DF71A" modified="2019-07-31" version="1">MEISEFALNIYKILVEWPLSFRILVGFIPFFIYFVVRYYFKSYKCKKDFVIEDGKDVEDEEICIRMKASFKEYLQNQSKVKTVSFMFNEDIGYEEMGFGKEKITCLGIVNAANSEVKPGMGGLNAGITVWVGGRYGIITDQQGQKEWCDLKMLNRLRKLDPKKIGLVAVSNFIEGHVFHVVGPQACLVGTQKYVKSLSGVTETLIKAYKDCLFQAKNLKCSHIIFPLISGGIFCESNPSEGFSESEFLNAVQLAVKKFIQNADFKDIKVYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L9</accession>
    <name>A0A4Q9M2L9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0007p0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020479486" evidence="2">
        <location>
            <begin position="20"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="911" mass="106130" checksum="FC792D1353CCFEDC" modified="2019-07-31" version="1">MRNLLEVFFFLNVIPLLWLLSHFNCTSVENNEHSRCHSSNTITASTSERYTQDILVEQPCSLRVSMDLENQVVDDDCVEVLTESENGVIILSSSDDENDNAINATCKNASICNEIQTTNKQIKRIYPYCTDEIHPSKKKFSESSRKDNCSLPLRNSKCKEIPKQDVSCINEYRFTEKDYEDNPSLGYYSYEEKGAPVAMLRSEKQLQSTYSCSHTNAARNETSIESKITKKSKSLSSIETLKETILLLSEPEKYGHKLKDSSLKEKYLEFIIDTKGKTYTLFNDSEDNMIGFTDIRTFITSDFYINIDLMQENLTYYFIFINNVAKNEQKYWEKLEDETDKLRQLTDEIINCIEKLNFFKNSCLWIILLKFVQSLSYIPVNEIYKKNRFGESESTLSEEYKTFNIYEGDEKILDDIKKSYETFDVIAKYIFLRTKIFSESTQMLNFIGKCLKFNNMDFHISLGINLDLDRVITDSIFRLSPDVIKLFVLQIEKQNFLDLDDEEFLPSVSFFFECIFEGLVDLKSEDITDFKHICKGIILAYLDFFENEAQQSDFSDCKNITFLRLYDLKDTDPKYIELTKMMKFAEALCVFYNYYIKVGLNNIKIKPIKSRKTCDVSDSSRWLKRGNIGPRNEAVFCYIQDRNVLWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYPRRHNEVVRCLHLLLLDRYKFKSSKRIRSHSVQEILDNEYVEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIKVGITSTDSLQIVETEKLRKYDLLANDLGLIYKCMMNWDGIVTKYHKSHLKRLEIPMNKKVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTAPLKEEKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M308</accession>
    <name>A0A4Q9M308_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0167p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000167">
        <property type="protein sequence ID" value="TBU19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M308"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0167p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8141" checksum="BCB99C9C34B417A4" modified="2019-07-31" version="1">MELEDLNSKKSEVSDILYFIYLYKNICVCVYAFVCLNTVNKGLTKGLFMGFLLKGVNNCGSNQKVLIYSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3A2</accession>
    <name>A0A4Q9M3A2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1153p0020</name>
        <name evidence="2" type="ORF">CWI38_0061p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001153">
        <property type="protein sequence ID" value="TBT99977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3A2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1153p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="194" mass="23013" checksum="5A6B8B758F12080A" modified="2019-07-31" version="1">MNTKRNLILLTIFKVITYSFNRKKQSDSLQFNSDSNDSTYCRYENVDDNVKIISFIKNKDLLHSETYRDESLYNESVISRQNQNYFHQAQNPYILAELYNTEDKKNFIRCREDMRSNKDRTISISDESETDSIQSNSDNSIEKYYDESTDSYVSNNSNFTNGIIGEDILEDYFEHQFSDSFSYEEEKNYGENFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3E0</accession>
    <name>A0A4Q9M3E0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0030p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9940" checksum="D3D1822D7D9E6146" modified="2019-07-31" version="1">MSTTKYIVESTEGFLLTDPKKIPTSGENILERIYILTLNTYEKERYQEEYTASYFKMTTVGKSLISTPEGKRKRELPRKRLLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5E0</accession>
    <name>A0A4Q9M5E0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0005p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="29634" checksum="58E3300F3504A097" modified="2019-07-31" version="1">MIKNVIDDVLYIKMNFFYIYRKMMEKRQPDKKLSAWQYVCETGKIKNNLGDKEEDKYKDKHVNVYEDNRDNIGDKEEDRYKDKHVNVYEDNNRDNLGDKEEDRCKDKHVNVYEDNNRDNIGDKEEYQYRNKYRTELEKKEIQLPKFIIENYKIIKTKMKFLLKIIIEKYFTVKIRIKEIFKLKEECKHHLLQLISNIIKELIALRVFVNSTKIFNYYNNYKIFISLVNKVDSKIRRIEKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWD1</accession>
    <name>A0A4V2JWD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2391p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002391">
        <property type="protein sequence ID" value="TBU07502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2391p0010"/>
    <dbReference type="OrthoDB" id="2195441at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="16154" checksum="009AC12CE64A10BD" modified="2019-07-31" version="1" fragment="single">MYNKGYNKGYNYEESNKNYDKGYNNQTDNNLKEDLPNNNNNSTNNTPNTNPNYILLTQFLLYICCFKKEYFTPSLHIITHIFKYKLYTFMNKNIIKMFCKIYNYKTDITYTTAENETLWFPFDPPIIDEIINMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL9</accession>
    <name>A0A4V2JXL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0792p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000792">
        <property type="protein sequence ID" value="TBU12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0792p0020"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="394" mass="44790" checksum="E743E803AF49E383" modified="2019-07-31" version="1">MKEYDIIIYGASGYTARFVIERLIKEQKRIALAGRSLSNINKNIISLDLKEDIEIFEVTVDNIDIITSKTKVLVNCCGPYIFTGEKIVKSCIEHRTHYLDITGETLFIERILNKYGEMAKRNGVFILNCCGFDSVPADMGFEYLKKHMNVDNFECESVMSLKNSFVNVATYQSLIYGLGNIQELRKLRRNEKKVKNKKIKKIFYNNLTQSYCVIFMGTDASVVKRSQNTLEEYDLSKKGEYSAYFEVGSLKNLILFMFYFGLIYFLSKFKFGRKILLAFPGFFSCYRIKPNGPTLSEIENASFSIVFWGKGVASNGEIIRNKLKIDGGDPGYITTATCLTHCTVVLLNMLEEKEMGIKNSLSLLEGGIFTPASVFSETDLIDRLCLKGVNFNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN8</accession>
    <name>A0A4V2JXN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0727p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000727">
        <property type="protein sequence ID" value="TBU12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0727p0030"/>
    <dbReference type="OrthoDB" id="2193290at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18535" checksum="37E079D9B8C58260" modified="2019-07-31" version="1">MEYENKIIFEHTSIKNILEMIKIDKLIYPLKYRKTFYGQLCNSQVKHGYLFLLDQKYIGCCSYEIDKECSNAYIMTFGIVNTFRRKGIGKICLEKLEKKLLNEFGIPIFRLHVQTSNSEALSFYKKNGYEVIKIEESYYRNILPKSAYFLEKSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW1</accession>
    <name>A0A4V2JXW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative inositol hexakisphosphate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0461p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000461">
        <property type="protein sequence ID" value="TBU13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0461p0020"/>
    <dbReference type="OrthoDB" id="5322816at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020640196" evidence="1">
        <location>
            <begin position="16"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="34107" checksum="014EB4CC196A3A7C" modified="2019-07-31" version="1">MNLIIINLILYFINAEKIEYCVSGEQKRYIINSPPKLKNFRASLLKKFPVSVSIEKRQKELKNKDIKDLENLNISGSAQPNILQLTSLLNILNTLSKKIIFVDLRAESHFFISPTDNITLDCKKYDEDIINQEEIDTKDFTEPYHVVMTYNRKEKKVVKVEDVITEKKFIERDFSDTVEYYRMPIKDHMAPDREILDKFINFIEGKPKGTYWIHFHCNGGKGRTTYMMTIMDILINGKNSTLDEIIGRMYLLGGSDMSEFNDKHKNQHYKRYQILKGTYQDIIKKKIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY91</accession>
    <name>A0A4V2JY91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0122p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000122">
        <property type="protein sequence ID" value="TBU20163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0122p0060"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="11950" checksum="C778669883A98386" modified="2019-07-31" version="1">MNLHSITPIEVGITSQDSLQIEYDLLENETGLIYKCNGIVTKYHKTYLKKLQIPKNVAAYIQSIKDGVKTKITRNIILLILDDIITAEEPTISMNKDSDLNNIMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KV19</accession>
    <name>A0A4Q9KV19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1661p0010</name>
        <name evidence="7" type="ORF">CWI38_0240p0050</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001661">
        <property type="protein sequence ID" value="TBT98646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000240">
        <property type="protein sequence ID" value="TBU18504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KV19"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KV19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1661p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0240p0050"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01513">
        <property type="entry name" value="Translation_factor_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT98646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU18504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="476" mass="51346" checksum="3947117719E14F7F" modified="2019-07-31" version="1">MATAFRRAINMCVIGHVDSGKSTTVGNLVYQLGFVGERVMEKLKNIAETKGKESFSYAFVTDTSDSERDRGITINNTLIHIKTSKFELNIIDCPGHKDFIKNMVTGAAQADVGIVIVPCAANEFEKAISGGTLKSHITISGIVGVKKLIVGINKTDAVPEGSQKQRFEEVRDEMKRIISKIHPDKDPIIIPISGYKGINIVEKGEKFSWFEGTMKEGQNIKTLEGAIDFQSVPERPIGKPLRMPIVSIHKISGIGTVYTGRVDAGVIKPGMQVTIQPADICAEIKSLEIHKEAQTEVMAGDNCGLALKSITKGDITQIKAGNVVSEAKNSPIVMFEGARAKIMIIDHPKGIKPGYCPVMDLGTHHVPVKLVKFLSKKAQGVKETITDPDLASKGDTLLCVIQPQKSTVMEVMTEYPSLAKFALRDGGAVVGIGAIEHRYSADEFKEVTGISAKTEGKGKVVDKKKAPVGRSKAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWQ5</accession>
    <name>A0A4Q9KWQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1482p0010</name>
        <name evidence="2" type="ORF">CWI38_0338p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001482">
        <property type="protein sequence ID" value="TBT99064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000338">
        <property type="protein sequence ID" value="TBU13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1482p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0338p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="149" mass="17453" checksum="0BB13413826AC027" modified="2019-07-31" version="1">MKINIRHLELLEIFFHKEKIEMSEMKLLSNIQLKESLYLCAKCDTGSLQCLFSKNNYSQVKKLSLTQFVIGEEDVQVFKNSLNLENIKFSNLALEQIYISDLFCNGEDYNIKYIYFSNFCISESDLKFISKLKKTQKIIVNSLFSSIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0B6</accession>
    <name>A0A4Q9L0B6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SBDS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1087p0010</name>
        <name evidence="8" type="ORF">CWI38_0989p0010</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001087">
        <property type="protein sequence ID" value="TBU00181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000989">
        <property type="protein sequence ID" value="TBU11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0B6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L0B6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1087p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0989p0010"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU00181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="230" mass="27053" checksum="2A419B9134217C1C" modified="2019-07-31" version="1">MFTPENLKKLTNVSVVSLKKYGKRYELALYPNKLYEFRKDESLCLDKILHTDKIYRNVSKGNKADLELFNLSNIEIIKEILKYGIEQKDEKTRNYEINKKETEIVSIIQKKVLDLNGKYLSFGKIKDLMRKSQFIIDLDKESKMQANDIIKRLGDSVKKVRMEVELFCEESDLSKILHKNMDYEIIKINMNSIFILVYTDDYKILKDIADNQNIGHVLHNSAEVEEEEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4H2</accession>
    <name>A0A4Q9L4H2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0482p0020</name>
        <name evidence="3" type="ORF">CWI38_1206p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000482">
        <property type="protein sequence ID" value="TBU02439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001206">
        <property type="protein sequence ID" value="TBU11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4H2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0482p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1206p0010"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="592" mass="70619" checksum="F88A95D3E433971B" modified="2019-07-31" version="1">MQILLWIIFVKFSKENSEIQTYYNMITEMKSNPIVFHVSALFIHFLNHKTFGTIKTELIVRTPISKQVNFEVLKEYIESLELTKNNLTSNELEMLCFTTYFKKCQSFKWLLVFRTRIIYVVFSKFKNIFKEYFPNFNTQSEFAKYMYFFTSEYYTYDDQTDNAMLEIQEEEKDIVSKDLKDILKPCGINTILTSECKRQKKSNLDSNYDTSNIYERLFSNTNSEFNIKDITQYTIKYDQNTSCKNHIHMMFTEFKNSILQHAKSCSAAHFFYSNMIELFSSIFQNYYAFSYHEDICKEYFNDDILNAYSQILKQRDEQANKMIFNSYYKICFTYLEDHLEKLLSYVTTKPFLEFENISCFLKEFICNPEYSSALRVGPFYVLLSLNPIKSMCYNEKVLVFDIDDTLFPTKLFEAHFNEYEYGFNYTDPDQPLESFMIKFIQNTKEYNESKCKELVGNFFCKEKNSSLFSIQSHLAFLEEFKQELQHLKAKKICFTNATQYHAEYILKQMNLVDCFDHVVHREIAYIDSTILKPKYQAYEFVENFLGTSPSNIYFYDNMLKNIVEANNRGWNAFLVQESLIKVLRESLVDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC05</accession>
    <name>A0A4Q9LC05_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="5" type="ORF">CWI37_0116p0050</name>
        <name evidence="6" type="ORF">CWI38_0083p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000116">
        <property type="protein sequence ID" value="TBU04581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC05"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LC05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0116p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0020"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16887">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="171" mass="20002" checksum="48F938704C2F62D7" modified="2019-07-31" version="1">MKRVENVNLTRKITIVSSSIPLTPEEQLENTPATHKWTIYIKSPTDTPLDYISTVTYKLHDTFITPLVETKYPFVLTETGWGEFNINVRISFIDINEKPISLNHFLRLYNENGESGCTNETHDEIIFRSPCNDLYRSLMENDIKEDNLTEKEEEEGYNIDNAIEYMLKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCF8</accession>
    <name>A0A4Q9LCF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZPR1 zinc-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0091p0020</name>
        <name evidence="3" type="ORF">CWI38_1065p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000091">
        <property type="protein sequence ID" value="TBU04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001065">
        <property type="protein sequence ID" value="TBU11724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0091p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1065p0020"/>
    <dbReference type="OrthoDB" id="2190013at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="256" mass="29111" checksum="87EE3C3B41D4E0C3" modified="2019-07-31" version="1">MQGSPGKSKSPKKEYKEYTSSDNKIENDDSFYKTDIICEICQGNGELRIATLDTPGEPKQKITTFECRVCNARESTIFNMQKDDREGYLVVSCNFSNKDDLGRYILLQKYSTVNFYKKELSYEYVSASDVVTTVENLIEQAADEIADTYGVPRRQDIVNKKPKDVTSSGEVLGIKNTESGSTSSVGTLESKEQAKHAIYLLDDLIKNPQFKMVIKDSSCQSRICPVNKTVSQCSYEDLKTFDDENVEHKKYYEKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDN7</accession>
    <name>A0A4Q9LDN7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2643p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002643">
        <property type="protein sequence ID" value="TBU06099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2643p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="63647" checksum="B30EBF39A68A0ADF" modified="2019-07-31" version="1" fragment="single">DKLVGVKGIGGVSDKGSIIRGIGGVSDKGSIIKGVTDKGSKLEGVSNSTYKQQGVTDSTYKQQGVSNIIDYFNPVSNIIDNYNPVSTSIDNYHPVSTSIDIYNPVSTSIDNYHPVTTTTSNIKGILGVNISTFNNTTTINNTINNIPNKKIRIKVINQPLGVIKLSLKQSFNDPFIIQYNSIINNSLYSTKVEGDNKGDNKGDNRGDSTNTSSITNNTNNISTNNTNHTNTNTTNTTNTTNTTIIMLSILNRLISHKGFNQVESFIEEHKSNFFTFKVLTLKEIKRKVINNEYNISDMSRDSNPLTNNPPTTNPLTTNNNNNPPTTTNNNNNTTSAYLNMSSYNKDSIGLPFTFLFNEYSVFMREIEEYFIYAMTFMQYNSIIYNLCKSMKNIYYKDIYMLIPIYKYKVLEIKGIYNKCISFINKLKGNKEIGLFIDKLEYKKYGWLKYGDMFKEMWIELVVERLKGNFYFCFEVFVEDLYKVFVNCCYFNEKNCSIWSVAVSMRKEVYEWVKSVYRDMLEWGDSVGGMLDRNKEEGDNYSNKEEGDNYSSRVEGDNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF42</accession>
    <name>A0A4Q9LF42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2536p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002536">
        <property type="protein sequence ID" value="TBU06623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2536p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12932" checksum="BB41F05D40FA512C" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFK8</accession>
    <name>A0A4Q9LFK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2509p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002509">
        <property type="protein sequence ID" value="TBU06777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2509p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="19961" checksum="A4092411220D5D7B" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVMKGDSEVQKYKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACDPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFCSTDKLHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFS3</accession>
    <name>A0A4Q9LFS3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain hydrolytic ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2667p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002667">
        <property type="protein sequence ID" value="TBU05981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2667p0010"/>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58013" checksum="6BABFFF10738B5A3" modified="2019-07-31" version="1" fragment="single">QGVSHMSNNIKGVSNKNNEQQGVSHMSNNIKGVINKNNEQQGVSHMSNNIKGVINKNNEQQGVSHMSNNIKGVINKNNEQQGVSHMSNNIKGVINKNNEQQGVSHMSNNIKGVINKNNEQQGVSHMSNNYHPLTNNTNTKPNPLTNTNPINNNLSNGFYEISMFYLKDKRLVIALLEFYKVLRKEIPSDLFIDLGLRGLTTILRETVERISKGEYDYKGLKDSRDIIKGNSDRGSVLEGNSRDILEGVNNRVYYKGVSDSGCELEGVSDKSNEQRGVNNKSNEQRCVNISTNEQRPLNNINNTNNTTNNVTNNNTNTTNNTTYITSSLVISIVNFFVPLLRNIYIPLLINNIRYFFNKEITVPSYKNMLINSLKRRNGVILLGNTLTGKSKLIRDCSVSNVYYYNPITLSNIFGCYKEGEWEDSNFIRDLRGVLGGGREGGSDRSVVKGDSDSVIGGVCNRDNVLEGVSDRRDILEGVSDRRDILEGVSDRRDILEGVSDRRDILEGVSDRRDILEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG12</accession>
    <name>A0A4Q9LG12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2586p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002586">
        <property type="protein sequence ID" value="TBU06395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG12"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LG12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2586p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="645" mass="73411" checksum="B3C35A44C10CAACA" modified="2019-07-31" version="1" fragment="single">QHPLNNNNISTNKQHPLNNNNISTNKQHPYNNSTNTQHPLNNNNISTNKQHPYNTNTLNNTPITDTHCCLDISVISIQIDNQTLECVYPIIFYPVNIKQRFFSESKDKRKFLSLSIGFYLESIIRYLTGDNNSSRDVEGDSDRDSKQQGVNNLYDNQQGVSNLYDKQQGVSNKDSNQQGVNNLSNTYHPLNNSTDKQNPLNNCTDTYHPLNNSTNTYHPLNNCTNTYNPLNNPNNTQHPNTPPHFTYIIFLLQEFVLNLEEDILTKLITFIPTYRNNTNYSYLLCNNCNKNECICYTYAGYTKYTSSSTNNQYTNNQCTNHTNTNQYHTHYQQQYHTNQHYHTHYQQQYQQHYHQYNNITIDTLHLHPLKLRFSFLKSTKNHFISYLLSFILQNISSLKLKFNTFLITNIKDYKILIELIINSYKIGLISQMYKIFGSLDFLGNLSSLVDSFSLGVHDLFYEPYNVLSNSNSNSIDFSIGILRGGKSFIKNTLSGVSNTVSRVTSSISKGVSLVSLDKDFNEKMNLSNNLIFYLDDELLFPDKLVFTNKYDRFVESCVSGVRGIVEKPMEGFKKGFRGFLVGVGKGIVGAVAKPVAGISDLACSVSEGVRDRVSGGEVVRIQVIGVGGYGMEIGEYGIGEYEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG76</accession>
    <name>A0A4Q9LG76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2478p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002478">
        <property type="protein sequence ID" value="TBU06957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2478p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12983" checksum="AE85F2714BC58F64" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLS7</accession>
    <name>A0A4Q9LLS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2208p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002208">
        <property type="protein sequence ID" value="TBU08896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLS7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2208p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="25147" checksum="5F27E3F90A4BF10F" modified="2019-07-31" version="1" fragment="single">VFDIDDTLFPTHKISSGFNKISGLFNTIPDRPLKDFLIKQEKRWTRKTEEVCEKIVEKFLQMNEFSELSTILSHLKFKKELKETLQGIQHRKICFTNANNVWAYYVLKELDLLDCFDVIIHRESENSVTSVCKPNEKAYKFVEKFLGISTSNIYFFDDKSENIEAATKRGWKAFQVTESLVDVIKESLESLEKSMQKNKRKNFFKRFLCTTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNF5</accession>
    <name>A0A4Q9LNF5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2091p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002091">
        <property type="protein sequence ID" value="TBU09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2091p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8456" checksum="19EDD9B09E3ACC9A" modified="2019-07-31" version="1" fragment="single">MSLSLYKILNVKKTATKEEIELACEILIKEYSLHQEPDEASISKIIQAQNILCERIVKYLCTENIDKIIVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNM7</accession>
    <name>A0A4Q9LNM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2089p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002089">
        <property type="protein sequence ID" value="TBU09934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2089p0010"/>
    <dbReference type="OrthoDB" id="2191084at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="420" mass="50249" checksum="AEA8011DAF00B897" modified="2019-07-31" version="1">MYRNNRLISTEESFRLISFYYQNKLNAGNIEDNDLIKKDIHFLYVDIMRKSGEKDKAIKFLSQMNYSYDVHELPNAIELINTYIYFKDYEGALDKFETFRAKHRYLDKLKIFLFTHINICNGKIVPNDDTYNKIVDMSIECLKEEFDFLLFEFLYNFVTSFWVPIVSTPLILQNESQESGQNDNVQSEFVEFKKIDTEENSCNVSIESKYSQVKSEQMKDFCTENDFKTDIANESTEIYKNKKSKKSSKQKRKKVKIFAKNPAISDDPNQFFWKFIEKLSFMTNPLYFEKLKIEEVKYLATVLNSEILHHRYILLKGFKSEKELFSYFKNKPSHYIFRNAVYFLERFHYPKLYFLTKKAGLLTEEMVLIKNAYKVRHKRIRDLGLAETRKILRRKKCYIKYTGQNKNKKAKKGRLSNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNX6</accession>
    <name>A0A4Q9LNX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M1 aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1982p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001982">
        <property type="protein sequence ID" value="TBU10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNX6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1982p0030"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="45377" checksum="6B36C87B6EB0BF6B" modified="2019-07-31" version="1" fragment="single">MKLKFFEIQMKKDKILKYFILCIVVSIVKANNDFNFKPIDYKLYLSLSGDTDSYEGRVDILLENSEKSNKIYLNSNKSTITEIHFYTENNKKHFIWKGILNTKKLDFDIKTDNDDNKVSDYNDVFEDDIVNYHEPFKLIPTLIDEKLSLYIPSDVEPSSNSKLIIMFNNKIHHKPHGFYKTYIDKEKRNKYQDIEGENKIYSTQFQPSYARNVFPCFDHPSIKSHFTLILRIPKYYTALSNTQPHQILIGEKYKKVFFNKTEPLPTYLLAFAIGVFNYTEIIIENKFSDYNYKKNLQEKQKNWYLGKNLQDILHRDKSETMSISTSSIFIKYNEIKSRNKESLQQKTATYSGLKIVETNNTNTEILPTNSTKERYMTTKSNISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP39</accession>
    <name>A0A4Q9LP39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2018p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002018">
        <property type="protein sequence ID" value="TBU10104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2018p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="680" mass="81829" checksum="7AEE4E0A6D495027" modified="2019-07-31" version="1" fragment="single">MFNCKIYKERKKNTKLFKISLDMFIRSRNRTFKILLNIISIVCMLLRLFSTQNGIFCLKVQFSAINEAEEYISFVENDNYKNLGNKTYYVNENSILIPFNTPVISKYNDNLFSICYPNDISLSFGIFDQLALENEDQVTIYIENEDLYAVSYFFNSLTIDDNIFVTIKPQTFFKILKYLNIFKVMRNKKYKYFIKILVYYSLIHNLDFKNLAFKPILNHLKFNNLHVRDVIECFLKLYMMKKAFIYEIFREYNQPESISSIFHSKKHRKNDDFLFMKFHTRYLYKYLLKPNFRDNWISIMHIFLVKKLYFNLCAYGNNFDMKIICSSLPKNFEKIIFVIVEELLPIFNYLQNNEYFTSKDNVKFIIYDNPEYFIDKIFYFKSIKKLTLEINQVYIEHIIKVENLTIYDKIESLKFILYSFSSLIFQNSVFSLSGRNKKFVIDLENTVYISDLENQLKFFQTYNFQNYLTKVNLCLFREKYDTTYFAKIFNFNLIKFLKIDLKNVQNNFLVSYKFLESFEALRGLSFENIKLTNKLFEVILCSRKLTTVLFDNFMVFDENELINQNLFNNSILFLGFYNLNMSLNSLFFLYLSKFAGLKRIILNLHHNQSLDTNEYCFNDEVRYLNIPKPKYHRYLPSLESLKYGNFFFAKNQTSSSILKILYHLFNLENLIELKYNTGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP81</accession>
    <name>A0A4Q9LP81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1927p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001927">
        <property type="protein sequence ID" value="TBU10228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1927p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="7368" checksum="8B890EAF2AB53A6C" modified="2019-07-31" version="1" fragment="single">MIKDNNRDFYLKLLDSDKFMNKVKIIEYSKFRSFYLEYKCFYDYNGCFCNISITLDELHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP86</accession>
    <name>A0A4Q9LP86_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1981p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001981">
        <property type="protein sequence ID" value="TBU10154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP86"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1981p0010"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF444">
        <property type="entry name" value="HECT DOMAIN CONTAINING UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="316"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="648" mass="77611" checksum="7AC798D5F46AFD18" modified="2019-07-31" version="1">MFLQNIEKMDLVLFKSQVFDILLFELICAPENKNLYLNDFFKNMMNIDTQLPKHCLKTSSGELKTKEFLEKLRTYMEKNSSEKNVYFACQTLLFYIKKMENDIFYDILHFNRETKYEDGEHFGTNLDITLSLFDIINLNIPSEYLNYLIDFYCKISRCDLFHFYSRIVIFDRSVLYILFEKYFKILLVLNKSYFYYKTRIDVTVNETHKLSNYDDFICLMYNITSNRISGDKKDFYDYNYKADTKQLKIDFLIRNMQIFDNSYKQNIVLLFEHLSIITKMAYLYEKFYIYQFHRGKFLFLQVNRENILDNFLNLVSSFDLKKTLKENIWYVTFGTELCAGIGPTLEFFTLFGKSMNRSRFFEMFKSTETSYMNKFAECPEYIEKVYFYTGIIMAKCIIYNTTLGLEFIDSFYLYLTKDCFTFEDLKICDSELHKSLSFFATSGKSSFHGYNFTWATNNNGIYEEFELVENGCNISLTSDNLEEYLQKITEFKLFKRMEKYLDKMKEGFCFILGDSFSNMFNYRDLSTMLQGEPDFQVEDFKQCTSYVGDYNSNHPVIIWFWNYMSSLEAIKKKKLFLFLTTFEKIPFGGFKSQRFLEYKFTIMPIENSKSLPIIHTCSNLLELPKYESEEILRSKFEYCLDSITYEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPC7</accession>
    <name>A0A4Q9LPC7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_2067p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="PITK01002067">
        <property type="protein sequence ID" value="TBU10047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPC7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2067p0020"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="51"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU10047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="241" mass="27418" checksum="A3D7C372A30E11D2" modified="2019-07-31" version="1">MPINNALHILEMIKEQRKSTTAPVDTMGCNVLARSKNKEIWRFQLLISLILSSQTKDEMTAKAMSFLFDGLLKKSEIVDNLYINKTSEDVLCIENTINTSVQDIAILIRCVGFHNKKAVYIKKTAEKIHSFGKMPDTLEMVCSLPGVGNKMAFLYLYYGFSKILGISVDTHVHRVFNRIGLVETKTPENTRKKLEKIYDKALWKDINKNVVGFGQVVCLPIKPKCKNCCLKNICKTSKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPD5</accession>
    <name>A0A4Q9LPD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1944p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001944">
        <property type="protein sequence ID" value="TBU10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1944p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="16089" checksum="67B33FB3FD3ECA5E" modified="2019-07-31" version="1">MVETEKLRNYDFLANEFGFAYKCSVEIIPYVMTWVGIVAKYHISHLKRPEIPMNVEAYIQSIVLKKTVETISLDRRRGNESGKNAEESRERASIDVIIGAQRDWEPTPSLNKAKREEDGGTTFGEPINNINEELDLEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPG4</accession>
    <name>A0A4Q9LPG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2152p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002152">
        <property type="protein sequence ID" value="TBU09411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2152p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="37661" checksum="EA372055CF8D568F" modified="2019-07-31" version="1" fragment="single">GFLVFLSNINVFIEKQSEFQFIFDSHYKSDSCFLLLAQIDDILAKKDLSEFFIKNSYDCNYKIFNRQRKKNGKMKKFEVIEYEEIKKNSCYLFKFKLPMSAENLFTFIKKVQGNSNFFKKEKENYLCVMFKDFLSGVERSIIEISLKNLKTRKLDKNTVIYISINKQDFVSKDIYLVFHRKHREMQKIYGYFFSLAMISPADRLNLKNIPTSALIMFKKINIVKEYHKKDYKAYKPMFLSIISKKKYRKIINLKLIWDDFEENFIELTLSFDSNDTMNKFVYRRGCYADTHEKKEYQSLEEIRSVFDAFLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPZ7</accession>
    <name>A0A4Q9LPZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1717p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001717">
        <property type="protein sequence ID" value="TBU10498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPZ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1717p0030"/>
    <dbReference type="OrthoDB" id="2192696at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="20857" checksum="FA462219DC7F94A6" modified="2019-07-31" version="1">MINRNLREINEKLEKIHIKNTKIINYCKPWISFFSTKNPQPFNAKPILNTPQSTSLPLNVTSPPQKPIYTSLASSESIEINFPKNISYEEESFIKTCDSDDSSLHPFNLEELPDIFKQEIVIQDIYFYIQSVKSIDYSELKNIFSQISTEKFNIFLNLLTRKKFILQRNNIFSVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ55</accession>
    <name>A0A4Q9LQ55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1730p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001730">
        <property type="protein sequence ID" value="TBU10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1730p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9263" checksum="F5E6DD08326F2CA5" modified="2019-07-31" version="1" fragment="single">MSENLQQSSLPLPDLSVVPRQVLKDSFYFEDVFSIAFQIFIPFVVSNETYNKTNDNVPEEFNETFDVELAYFSIFHFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ9</accession>
    <name>A0A4Q9LQQ9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1520p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001520">
        <property type="protein sequence ID" value="TBU10839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1520p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="73915" checksum="4B77FDEC7D08C15F" modified="2019-07-31" version="1" fragment="single">MENPCTLAISEGNILRALLTIFDSVTADLNEWPRIVFFLQYKQGLKECQELAEQSFGDSIMRNPTALDKFLRKIKELSEKEIVPVVVRTRKHPNEWLIYADSHVPMTVTGVARIIQAARACIDEMKSNAKLIFAWKESKERKFSKLLLSKDLLFNLDLSKTNDLSEALNRIFELLRGRFYLGLSERFESEHVVKRDEIVSFWSTMWNKNDDTVTYDDYLILVVLDNYLRGVQGAKEQALLNIALNKEYGNNLKATWIDVIISKWKIDISVGPEKIMNQKIQRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNNLFSTLSAMTDEAKVFLEVIGLEINKENVYKYLGILEDSRRIPIRSSFEDVQSKLIARVLRLFHTRLNVKNQFSAINQHAISLINYHIGLDGAVHAVLVKNQIHLRPGCKQCLYLPRTELGRGLHSVEVRSEHMLLQLLDCLEKNKEISTKRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSSKTVDHLATRCEKMLDHDYTRRHNEVVRYLHLLLLNRYKFKSSKRIRSHSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQV8</accession>
    <name>A0A4Q9LQV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1464p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001464">
        <property type="protein sequence ID" value="TBU10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1464p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="72"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42139" checksum="7504FE5496029797" modified="2019-07-31" version="1">MTQRKQKLVLLTLITLLSFFSGFLTGFLVHENYFNDSNSPKDLSNEETDTFEFIDETKDKEIKSIRENADICPLKNSGVMCYFNSLIQCMYSLKEVKNIFLSEDSSNANSGVKKIFKDLFIKMGKKDSSIDTKNIIQNILAINSSQEFKNINKHQDIHALYVFLIDNCLFNGNSINEIDSKEKFEEAAKDSNISKLYLCLEKTHYFVAENRTSTKFEIWNAIIACAKTFDYQMIIDQYFKKEYITEESAENKNVLVNIEIEAKMIRFPNVLVVHSFCYSEDFFFPADIKDIKIENEKYSLVSAGCHAGNTESGHYITIRRVKGNIWAIINDNSISYYKTRNVLNFLRKHRFKPTLAFFEKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF6</accession>
    <name>A0A4Q9LRF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1621p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001621">
        <property type="protein sequence ID" value="TBU10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1621p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14552" checksum="0AED815D95BFE788" modified="2019-07-31" version="1">MSDIYANVLLNTNLVDKKEYVEPQLSIVEGNFDENVVLKGLIFLCIFSKPEDFIEMIEIIKKILDTYSNLECLERYIESIAHEIEDTKLNEGNEIYFGKLEGFKKIATFFMSNKYFIKEDLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS24</accession>
    <name>A0A4Q9LS24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1488p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001488">
        <property type="protein sequence ID" value="TBU10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1488p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13078" checksum="1C3E37C52F7679E2" modified="2019-07-31" version="1">MLRKFFFTSISFYLIYRFYKYQFKKLLNDENYLSDLYVKKKSSSENEVIKTTLNEAKRLASSGDKNLASEYYMYAYQVLNCDWSQILEEINPNDTELLNVLTKKKNEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS86</accession>
    <name>A0A4Q9LS86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1233p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001233">
        <property type="protein sequence ID" value="TBU11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS86"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1233p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SULU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="568" mass="65955" checksum="F2C5E94F5BEB56F3" modified="2019-07-31" version="1">MGRSFAYCFVHVFIFYYVKNLSCSDTNYTNNLLESIVSSNLGQKNTYQFVQKIGEGSHGEVFMYKSAYTNQKVAIKVQIKTCRLDSQEIPVLKIMNHPNIVKYIDSLVIGGYECIIMEYVPYTLIKYLNKNEFNFMNLKIILKQILDAMKYLEYIQVIHIDIKPNNILLDENLNVKLIDFGICCTIQDESLNFSIDSDLDTALKEFPQIAPEILSDDFFDNSADIYSFGYVCSFIQERFIKNFDFAEKNVRNSNVLFSNLIDISFKKSPVERSSIRALIFHPFFDELYEFLECFCNFDNIKLSAEAMKIEINDGKIYIKKENIEYTLYCLCHVKSKTLYSIFKSKNAEALDVSTNPDYKTDDSNTNKFAVKKESNILPIQFLNKEELLMIKSVFELIKKNAKKLQINSNPLDENRIDSYEDQIKKREHEIESSKDKLLAHENQTAQDLNRNESNNIYFWSDTDTKATIKKDEIKKVIKKMYEDLVKTGKEKNNVIMHQAFEDPSVIKNKGDATLILDLINSLKFTRIKKGGIISICANGVPQMIKDKKQGQDYDKLKNIIEEKIKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS92</accession>
    <name>A0A4Q9LS92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1364p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001364">
        <property type="protein sequence ID" value="TBU11137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1364p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020433327" evidence="1">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="205" mass="23864" checksum="196E0844A5AECD01" modified="2019-07-31" version="1" fragment="single">MFKKILLNIVLIGINIIKSTSLEQRPTSETDVNCYFELLCRIENFGLKVFEKYISIVGNNVRNDCGIFIFDRDTEILELTRFFLVMFPKDKKYMFQSNIFLKNLGKEEIPLGEIAKEAKWVYTATVNEFKSSTYTLSSSKIQDTFEYVEKVEILRHLIEKNTKLQNFDIVDNFCFNRTFSPSLYPCKGKEDSITIILLGLAFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD6</accession>
    <name>A0A4Q9LSD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1334p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001334">
        <property type="protein sequence ID" value="TBU11187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1334p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18379" checksum="5D5DAD877C42F4B0" modified="2019-07-31" version="1" fragment="single">GITSQDSLQIVKTEKIRKYDLLANEFGLIYRCSVEIIPYVMTWDGIVTKYHKSHLRRLEIPMNVEAYIQSIVLKKTVEIISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGGTTLEEPTNNINEESNLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP0</accession>
    <name>A0A4Q9LSP0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1357p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001357">
        <property type="protein sequence ID" value="TBU11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1357p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="101061" checksum="F1C98880A6655AF5" modified="2019-07-31" version="1" fragment="single">DIKIEKERYFGEYFIKIKEIYTKFCYEIYKKRVLFSEKEIKNKIRLEKERIKIDLVAENINQEIFYFDILKLHIADIYLEFDKTKKEKIDNFIKSGNKNVSIENIINLYRMDFGENRSFQPFFIDLNTEYLIEQSLFSMCLKINYTIQQKDLKNISVIQPIIKYYESVDCLKFKTSRIYDFLVKLYFDYKMFDEINDVKNKVSFEDLETLYMIIFALNECVDFENSLEYIFQNNIDEMIIFNLENNYLDCNKNFSDNENISLNEKLMKIRIKNTDSIKIEIIGSNFKCATDYETKKTEFKTYVNDKFIKFYERLEKNKSKLQIIDDKTKETLIKIIEEIFYVSICSKIEFQRQNYFELYDSDIFDKDSNFYFFKAILSDNFDDKIAFLEMSVQKNRLNHRANYKLGELQNNLDKKIYYFELAFNDSKNYAVDLAMCYNIKYGTRKAISFLENNFVYRKNQFAYFFELGKLYFKENEFLKAENSFQKAISIKEDFECYVYLADSLEGLNRFENSILILEKSMFKFKSHVLILKKIKLLNILGNSEESLFEINRLNSEINNSEFNFDKNEIQIVRECLNFEKLTSYNNIMRKTPNEFNKYFEDCQKLLKAEYKIFKDFILKLKIDFYIFMDKKNELEDEFYIQSQFILNSIKFKDKFIRNEINSDFEDIIVTKFIKNSSLIQRNEDFYNFIGLILLNTKESYNWFYKAIEFKNNYKSWAYLALKYLEEKDYENSFEFIERAITLNYENCLVWCIKLLICALMEPKICESIFINFLRFFEPEYSDFLYYFLEKYRWFEEVELIQNCLNISRNCETKNQIQEILIILKNNIVQKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW8</accession>
    <name>A0A4Q9LSW8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1078p0010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001078">
        <property type="protein sequence ID" value="TBU11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1078p0010"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="392"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="652"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="81215" checksum="F8E58F53CB77B52F" modified="2019-07-31" version="1">MSNTPDEKMLEALKSLSSKLSGLQKESALYKIKNLERRIEEKKKGLSEEKDKNIYASCDRKNIEAKINKEKNIVRAFEKLISVDGSLVEDLTAKIQTSEKKIFFLKKHLDKAPDIDEQRQKFSKTTGNVKIKPVSIECDPLYEAKMLDFYIDNELKASANINSNDEIIINLENNIEFEIVLVGKDNVFLGMVFFACERLVIHGKDEDVTFKFEEDAELKVKLSFERETKLIRKNAEIVCVYKDGHALENYYNIAPFYCCVCNNIASLFFESYRCYKCKFTCHKKCANYILFKCPCAKSIETEKHTIRYDIPHVLQKQSQLGLNWCNHCGNRISSSESAFKCTKCNQHFHESCSSFVFKSCGMEYDLRIKMADFKPPVSEVQEKDSKIEISDFLLIKVLGRGSFGKVMLAKYKPESSIIALKILKKESIVNANDLVYLELERKILKLVSLPPHPFLMKMEYCFQDSKNIYFGTEFLAGGDLFHLVSKGKFSYQQIKLYACEILLGLEYLHSKNVIYRDMKLDNVLLCEDGHAKIADFGLCKDNIGPMTITHTYCGTPDTIAPEIILEGGYTKDVDWWSYGVVIYEMFETEPPFNGATNGEMCAAILEKEVEFNSDIPSVAKDLILKLLQKDPKKRLGSGENDANEIKSHPFFENVNWEDVYNRTIKPEFIPKSNLTDNFDSYFIEEPILITPTSSIRKYDEYFKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT52</accession>
    <name>A0A4Q9LT52_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1098p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001098">
        <property type="protein sequence ID" value="TBU11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT52"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1098p0010"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="44737" checksum="B1D61183942A028E" modified="2019-07-31" version="1">MDEEDIPETDFYDLPENINDIFKLRTLVFKNLPSTAKLQDILDFITHGDIENVEIDKMQNLGKVHFFDYTSLYRCYIDLSNQEVVIDNTTISIGIEQSSKLSLNIENIHNLGATRSVFLVLDEFLDETFFTEYCKEFGEVETIRIVKDKSIIYCDYFSFYSAIKFIENTMKDPLFTNKRFGFGWDRCFRQMSDTDEKSISLFNSNKTVYLGNIQNDISAEDILDSIKGGSIFCLKIHREKKCAFITFMSSLSAASFISLCNKSPLNIKGYRIKVNYGNNTPTPVPGILAVYNHATRVLKIEPVDDELTYTKVQQDCKDFGEIEKIQFGENSVKINFLFITDCYRAYTELKNKDFYDNYNLSFGNDRCGNTSALDVVLYLQENEFFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH8</accession>
    <name>A0A4Q9LTH8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1509p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001509">
        <property type="protein sequence ID" value="TBU10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1509p0030"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="465" mass="51922" checksum="252C1FD277A8C651" modified="2019-07-31" version="1" fragment="single">MFPYNLPISKYSTKILTTLKNNNTLIITGSTGTGKSTYTPLLLHNNGYNKILVIEPRRIAVKSIYNTLYHIITDTGYNKEKFKENRDIKENGDNGEDKMDTKENRNSKDNKNHTNTNTNTNTNNILGYKMRFDSHNSKNCNIKIVTDGTFLNEVLKSSKGRGSKNSRCNNIYPNPNPNPYICINNISNNTESNNPISTSNNIYPNPNKCINNTINNPISTSSNIYPNPNPNPNPNTCISNISKNPNPSNNISTSSNIYPNPNPNPNICINNTINNNTKNNITINNILSYSVIIIDEVHERSIRTDIIISYLKYINFKGKLILMSATLNTHIFIKYFNCNIITINDICYPIKYIYSECAVSDYIIEAYQKIKGIVSGKDIDMFKGGEGVNDSSRLEGVNDSRDRVGGVSKSSRLEGVNDSSRLEGVSKSSRLEGVNDSSRLEGVNDSSTLEGVNDKSIDNYKGVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ1</accession>
    <name>A0A4Q9LTJ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0970p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000970">
        <property type="protein sequence ID" value="TBU11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0970p0020"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="590" mass="70617" checksum="DB713E216B129585" modified="2019-07-31" version="1">MEQIFSWRNFESKEDNHIIYSKLAHCMKTRKFYQEMGLQSYGYDEYGNINIGQYVNNKYEGFVYTKDGLFALLKDDEEVIFSPTIEKFYTDCDFLINLMYYRPAKSLCFRRLENLKHSFVMYQNLAAEKEKKEQKLSSKRDFYKVIKVDTHVHHSASMNSKHLLKFIKNKLLTSPCDDVYQKDDKIYTLSEIFKELNISLENLCIDTLDTHAHTETFHRFDRFNFKYNPYGQPILREIFLKYDNYIRGKYLSELTKEVFNLLDDSKYHYMEYRLSIYGKSKLEWDILASWIIDNNLDNEHVRWIIQIPRLFMIFKGSNLVNSFGDMLQNIFEPVFEITQFPERNPKLAKFLEKVVGFDSVDDESLKERRYHRKFPLPDLWCHKENPPYSYYIYFLYANISSLNHFRLSKNKNIFSFRPHSGECGEVEHLVYTFFTAQSISHGVQLRKSLILQYLYYLAQIGLAMSPLSNNSLFISIENNPFPDFFKKGLLVSLSTDDPLQFHFTKEPLMEEYSVACQIWKMSSTDQCELSRNSVLQSNYEHELKKDWIGDKYYLKEVESNDFSKTNVPDMRIYYRYKILQEELKHMNLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU33</accession>
    <name>A0A4Q9LU33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0882p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000882">
        <property type="protein sequence ID" value="TBU12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0882p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="397" mass="46521" checksum="EB1614E84B24BEBF" modified="2019-07-31" version="1" fragment="single">LKDICFQSVRITKNYWKSILDLKNLQSIVFKKFTVIELAKEFYIGMKYCKCTDSLTRFEIHDITGENLVFAFDFVFLLKKIRILKFIVINGYVNLFLPRTYNMKMNDSLEEIKFFGLFINTFCVRYILRNAGLKSLVLDDCRFEGCSFKDLGSTSLVTRLQVLKLKYVSISVEDLKFILELKNLVYLEITECRFCLLKSSKLNSERCFLREKPHSTKDTENNFSLAIDSFAKLEKLKIYNSGIDLMKSNFSGYSTICSKIKKLTISNTDLYLKDMQIISNMRSLVSINISRCVLNNCCVSNMKNPSFLKNLLSLNVTYIPLKKPDISFIISLKKITKLKLSIIYLDISNIWLFNSNNFPSLTLLVLVYSNEHHIKQYAFLKEYFCRILEFRYHKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU39</accession>
    <name>A0A4Q9LU39_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1074p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001074">
        <property type="protein sequence ID" value="TBU11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1074p0030"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20314" checksum="F494F1DAB9F91713" modified="2019-07-31" version="1">MAVGYKFTKVLQNTKVFFENNQNRHAGLKKQNEKEILTTYLKTGQYPAEYSKEEKGLLRQRAEHFTMLGDYICFKRRDHLIRAVFGFKTVLIKQIIQTEHALAHIRVNKMMALFVEKYYGIPKAYIKEYVKDCEACTRFNCLKTIQPIYINHITKIHALFIMECVDCMRFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU58</accession>
    <name>A0A4Q9LU58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1281p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001281">
        <property type="protein sequence ID" value="TBU11291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1281p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="80" mass="9067" checksum="2DBC59B7F412C598" modified="2019-07-31" version="1">MPENKKKSNNFGLYRESNSGSEIKREILIGLMHVMRISSDPGTVTSSCMHPMEKKKSYTTENMNGCYGKGSEMFNIISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC1</accession>
    <name>A0A4Q9LUC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1031p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001031">
        <property type="protein sequence ID" value="TBU11806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1031p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020982375" evidence="1">
        <location>
            <begin position="22"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="446" mass="52576" checksum="FFF1DDF7C5D3A732" modified="2019-07-31" version="1">MVVLSFIGYIILLTCINRTFGSISDTTQVTEKSQDINQPGDRVCKKIDIKKVTEKSSFRIKRPFCISNDETNNPKNNITRNIYNHFRATPARNAHYFRKYEHPTEFYNEEFYQNQQARSFNMYTVHPNQVSHLTSNVYTGLLSDNEIVNCLFHRLNSLNYFRNFRDFLPLIEYHYTFKNIKNASAVILHSRILDNIRINEIQIKGFAKTTDEERLRIWSLFTEKYSKIKMIDYDSPLVSFFPGIKMLKDFIYKLLTEKRSLLFSSKEMIAGLSKENSLDIFSYGHGAKNIINVHKKIFFTILKKILCKNFNLSRNFFITLRITEIGCDYLSDDKLYLNKAYKCHFLRALIDSIFFLDDVFMNTASIFYEKNVQNINLKTGYVAHIFFDFSELEKIEIDPGLSLKFIKYYLILLRKKKFISSANINKIVFKNVIENLAIEVDNLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF3</accession>
    <name>A0A4Q9LUF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0578p0030</name>
        <name evidence="2" type="ORF">CWI38_0861p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000861">
        <property type="protein sequence ID" value="TBU12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000578">
        <property type="protein sequence ID" value="TBU12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0578p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0861p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16817" checksum="3A96FA87A49F1BB2" modified="2019-07-31" version="1">MNRRNGYIGAFIILQLLQIIFSAILFNLKLVEIKFFTTSVVALTFLHISSTIYIVNAIYEKNLAQIFVGIFISTVGIVAEIFNAFDSDTFGKRFFGILVVLTFITQLVVGLRLSYNDLLDIEWYYFKKIGADADKKGKFINLIIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR2</accession>
    <name>A0A4Q9LUR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0369p0020</name>
        <name evidence="2" type="ORF">CWI38_0807p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000369">
        <property type="protein sequence ID" value="TBU03027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000807">
        <property type="protein sequence ID" value="TBU12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0369p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0807p0020"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="286" mass="34548" checksum="EAECA73D0FEE3447" modified="2019-07-31" version="1">MILEIFLKLKRCYIYSNEKDEIEQFKLFLNSVNLEYKETEEKNILSLNLTKNTNNLSDKLNTETEFEINELKCKCGNNFDIKSFNRLPTEGWQEYIDMWSCHNLEFKEVAKLEMRPRKKGILYSNFYFFINKNDFPCSCFQTENKNNINVFTNTQNNVYKVFFNQISLNISDNTLIFIFFKEYFLNNNEFIFQHENINYEIKYFEDILIYEGQYIEIESLFKEEEYQNKLENVCKKAIKIGFKESDMIVTHKNLLNIFFCKYIYNICVSKSIPIKIMDYNISFITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR8</accession>
    <name>A0A4Q9LUR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit 1 of eukaryotic peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0945p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000945">
        <property type="protein sequence ID" value="TBU11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0945p0040"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="33548" checksum="B97DBF3A0885FC16" modified="2019-07-31" version="1" fragment="single">MDEVQIWKTKKILKNLKNARGNGTSMISLIIPPKECISRSTRLLTDEYGTASNIKSRVNKNSVLSAIVSAQAKLKTYSKTPTNGLAIYVGTVVEDTKEKKVSIGIEPIKPINTSLYMCDSKFHVDDLLRQYEDESKFGIIVMDGHSTLFSTVQGNVKTILQELTVDLPKKHGRGGQSSVRFARLRLEKRLNYIKKVAEIMNGIYLTDSKINVEGLILAGHSDFKNELKTCDVLDHKIREKIVKIVDVNYGGENGLNQAIELSEDVLKELKLSKEKNILKRFFEEMALDGKYCYSIKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV56</accession>
    <name>A0A4Q9LV56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1186p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001186">
        <property type="protein sequence ID" value="TBU11480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV56"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1186p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="545" mass="60037" checksum="16BF709A262F7515" modified="2019-07-31" version="1">MLYKKEDILNNGKLDNLPNYKIFTLKAPSTPFTSYLNNVLDNKSDILTKEMEINEKEIKGVNDNSILKGVTDKEYCNMEIKGVSDNSILKGVSDKDDYKGVNDNSILKGVNYNDNTIIDIKGVNNEPKENNTNCDINNNTDVLIPSSYYKDGLIICSEESVIKERGVKRGRRCNKIKGVKKIAFSKEGVKESGINKGGVNNTTSNNNNKEGVNEIGISKMGVNDIDINNKEGVNNTSINKGGVNNIDINNKESVNNLDTKKCKEGVNNIDIITEEYLNPPINTKEIITCSKESIIKSSKTVESVVNEKKEVISSFIRRRKKIKVKEINTNVIDIGGVEDIKGVNDSTSNVKGVSTTMTSTYKGVTTMTSNIKTLEGVNDTPSILKGVSTMTSTYKGVTTMTSNIKTLEGVNDTPSILKGVSTMTSTYKGVTTMTSNIKTLEGVNDTPSILKGVTTMTSNIKTLEGVNNSTSNIKTLEGVNNTNSTYKGVTTLKSNIKTLEGVNRVRSYKRRRKSVMVPKNYKVLDKKINERRITSNGRIVKPKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA3</accession>
    <name>A0A4Q9LVA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0809p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000809">
        <property type="protein sequence ID" value="TBU12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0809p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16405" checksum="CF22C9483B6DD52C" modified="2019-07-31" version="1">MEGNEDTLSDENSNILSNSNLSKYWLKFYLQKTLEALQRDGFNDDNASGYDEVDEKSKRKDELDEKGKRKDELDEKSKRKDELDEQGKRKDELDGEHEKLKKMFSYPPKKSNPDTKNGAKKCEKPSATCEIVHKDKREESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG3</accession>
    <name>A0A4Q9LVG3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NrS-1 polymerase-like helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0672p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000672">
        <property type="protein sequence ID" value="TBU12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0672p0010"/>
    <dbReference type="OrthoDB" id="2375545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="NrS-1_pol-like_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051620">
        <property type="entry name" value="ORF904-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372">
        <property type="entry name" value="ATP BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372:SF2">
        <property type="entry name" value="SF3 HELICASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NrS-1 polymerase-like helicase" evidence="2">
        <location>
            <begin position="714"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="987" mass="114249" checksum="82DCF9C8EF24B779" modified="2019-07-31" version="1">MKTITKTNEEPGSEFELETVIDEWHEENLVFGYTTSIFGKRMTISGKDNFLELYKREIPKGYFNEFIRANAKVVLFFDLHSKEFQLDSLVDDIKRLVKGYFSGFDIQFIVSDATGKEKFSKHMIVRLFKEGKEYVFMNVSEVLSFVREHLNLPGVDLNVYKPGGCLLRAFGASKEKVGGKLVFDAKHTGPRKELDLIEHFVQWPGELGECIRTFISKQSFSCFKEESLVCNNQAITKVEGRTSDSKNSLFLKLLEWFHFKSKKIYRPRESEVKDGMLVIYVDVEPLDVCPYNVMHKSNKTYLRITVVNAVLKCHGCRLKSKNHLFEVKLEDVLNKEEIYILFRGNILQKQLLNNTHHLFLSKDPKAGLPIYNGSENSVRSKVGSPEQVKEFLGIESINMDTYHNLTASSYSVVSQDKSIELSFPKEKHITACQKELKRFSKNFVELNIYQSFTPNTTINNYVLDKNMNSVACLEEMYDKPNYIEIVYDEGYFLKSKLELDLDCEDSFLRIFMDSPTPVFFARFLTVVLGGRAIVVGDNLYVANINNIYKEYSKEATLGILAYLSEQFLKGLDGSRKLLKAQHANKDCQDRLFSKYLTMRLNLQSPAFLKSTMSVLFPYIRDEEKGLKFNTKFKLLPLKKGVFDSELRRIRETQLDDYISITLPFTEQDLLFSDHKKVAYLFLDNIFKNECEIEYVLNELRIILFDDSNDKVYFLIGEGASGKKTFINMLRIALKNLVGDLPVKALSNSKTLGMNRFFVNLRNCRIGVVAEYGAQILRVDIIKRLAKYERITVGSLYANPVTFPFKTRLLFVGKNLPKFSAVVDYALERRMKYIYFAKNLSIKENIKNHLELSNESVRHAIGLGLLQLILKEPINKELQIPTTFLRYLSYAFGELKAFVKFLENVIQEATDGYITFFEVYCMYHELDTEHTSKDVCRKPEYSTKFTEFKSYVKAKFNLDESHTRSADRKSIRVFKNLKIVSDNLNEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP8</accession>
    <name>A0A4Q9LVP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0795p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000795">
        <property type="protein sequence ID" value="TBU12346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0795p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="20189" checksum="6F2C50B021911B4D" modified="2019-07-31" version="1" fragment="single">DKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLKLPTNVEAYIQSIVLKKTVETISFDRRRGLESGVNAEESWERASMGTNTPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVNEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW7</accession>
    <name>A0A4Q9LVW7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DnaJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0725p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000725">
        <property type="protein sequence ID" value="TBU12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0725p0020"/>
    <dbReference type="OrthoDB" id="2191416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="50793" checksum="0197F65842DAFB5D" modified="2019-07-31" version="1">MGQRQSKPIIKSSYDILEVDENATREEIRKKYVQLLQKNHPNMNPSGSNEKTVEIIRAYKEIMKIIEQKEAEPPKMEELEIYTVSYFNTQSKDDFYIKVNKLYSTIYNKGPQFGFENSRNFSGFYDFFKKYKTWNNSQNEDTEFQKKYSYKIREITNIICMLDPRIKKPTKKDTKVVNRKEVNIFIEKEFEDEEYFVETKIQTTFLCDFCSKKYKSKNQLLNHFRSKKHLEGVSYHNTEPTKFIDSQISELMKEMENSNLKKSKAKKDKFNFEFTQEIKSFSNDDHEEIRSEIYDTESFESSINRNSKHMNKKLEDLKILKNEPKVSNNDIKDSGTEISEMNDESKNIKNEIESKVNEVSKKMKKIVSVKTKVKGKNKEVKILRKIKKSENDHIEQPQFLVCRICNIIFPSRKDLLQHVTSIHNSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA8</accession>
    <name>A0A4Q9LWA8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0991p0010</name>
        <name evidence="3" type="ORF">CWI38_0956p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000991">
        <property type="protein sequence ID" value="TBU00480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000956">
        <property type="protein sequence ID" value="TBU11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0991p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0956p0010"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="50"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="206" mass="24125" checksum="E447F49069375C01" modified="2019-07-31" version="1">MHKRIKTEVISSDIEIKNGILEETNNYIEEITKKYNNYGIKIINEFPEPKKIFLKEIRPRGYQKKNISVRRGVVSSENIEVGSFICELPCEIYLKYNFSDLKTNDSSFFYHPNLNLVLKVLDKNFSIIRKSCRPNVELKTLIIKNLNQKKFLAERANRNIVRFALYAIKEILPSEEIFIEMDYKYGNTNNIQKCNCGNKNLCLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD8</accession>
    <name>A0A4Q9LWD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0877p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000877">
        <property type="protein sequence ID" value="TBU12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0877p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="579" mass="66007" checksum="5414ED5EC2AAF25B" modified="2019-07-31" version="1" fragment="single">MYPSISNATKQTTDQNLNSNPIISNKPMETLATNQYTDTSSEKTCFSYDMSQCCVDSKFTYSTDDVLNELLSETNSSEYYVVPEFMCLTDDVLNELLPETNSFENYVIPEFMCLTDGVLNELLPETNSSEYYVIPEFMGLNDDVLNELLPETNSFGNSQPNFMPFPDKPNKIGKSPSVGPIEGNRYAFSDNIVEQGNSFSSSYIANQPTESCERKRLRSSEKNIKCNSTENLNIMLPKQSDMQPTGFEHSHSKNPTGEKNYAEIFQTKVINEMENNSGNMCQNYKSFLSLIPELYLEIDNEFGITINNNVVYDSMNKILSRENYTEVILKEIKSYESVVIDADMIPGILLFANTLLNFEKMYLADLEPYQILQFEDSMTVIIEKIKNHRNLGMFYELLKFVYYYQKNIFYHIAKNYILYVYFILAKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMAFRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM6</accession>
    <name>A0A4Q9LWM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0515p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000515">
        <property type="protein sequence ID" value="TBU13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0515p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="17717" checksum="2AD7C5466FAD1F62" modified="2019-07-31" version="1">MYLPSLNLNRLLFILTSISDILYIIALFRLKVLVWYILIPLIVLQCILKMYLYLVCFVTINRKYLTIAIVSLIVSVIENSYLCVRIFFIYIFFVVDVIYALIFYLSFVFFCLQLLLLINCVLMKKILMFDVSIPVSFGDINFASIYGIGGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX99</accession>
    <name>A0A4Q9LX99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0805p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000805">
        <property type="protein sequence ID" value="TBU12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0805p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="796" mass="95408" checksum="F34C0A38ECDC1257" modified="2019-07-31" version="1">MSFNFNIGSITKLNSKKASRHLYFLLIYFSCWVYLTTVSFYVVNDENRIKNFSTINSTSRIAEIENKLTDWFIEEDKISLFENNILCFESGEETKYYNPTILRISYPNEMLLNPIFSKTSFESKQTNIKIFLKDVSYSALLLFLKLIDNSDIIVNQIKMQDFLDILMIISVLDIEKSKERNIFLKELLRNFMFAMENGNEFFNFEKYCESYHYKHIKKTILMDLLIFFIDFITFNDKSAQRYIVSAERKLRFKNITKYFTSSNSLEKSKINGINLRLDDTTIRKLYRIMKSRYLIITWSILLEATNLNLLYLIFWEEEIYIKLVGLFGITRLHLDKLYIYYYENPMNIFTKKQTDIFTKNLKVLKIEFDSTPDELKKLLSLCCNVQKLTLSTKKFDFERLDCLINFSLQNPNINCKIYCLKYEFIDTEIDLLKRIPNNLVCYVDYAKRQASDIEIPIENLPFLRQYYYQYPDAKESSILSKHFEIYETIRFKALGLYFVHDSSYITHRDTIFLFLKHFNTIKYFSLRNIIICNELLVYILESNTIVCFTISNFICAFNLKCILKNNIINRRLRSFKIENSLGYIDSSLLIFMSRLECMQYVKFVGIFVKNLTSYLERIYRYIFGSEKQIESKIYIIRLEIIEAVLANKSNILNFLSKIIDFTNLVKIIYRVNMITETEYKFFGQMRNLETVYIVIRNMNEYIDFKKLFINRDLFNTVSSLSICVSKILKEDIEILRLFKKLFFLSLSCEEIYYETILNIKKEHFKNTQFRVNRPIRYERSYEVNNYLDSEFNLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC2</accession>
    <name>A0A4Q9LXC2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED18</name>
        <name evidence="2" type="ORF">CWI38_0460p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17513" checksum="4F1FF03DEB73DB26" modified="2019-07-31" version="1" fragment="single">SCSNSNFLIYKNEPDPTKTLKTIINKINRSEVLNCEDTISFLNLANFKQEKKLFVEGIEYVKDNIHIEVTVHSITNSEIIINEAFMENFIRNYMTNEIDNSLFNSCETFFVKIYTFAQTSEEGENLVFSESINLKKYINLQKPPVNFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG1</accession>
    <name>A0A4Q9LXG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0761p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000761">
        <property type="protein sequence ID" value="TBU12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0761p0020"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020232114" evidence="1">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15637" checksum="22B18657B6EDF98E" modified="2019-07-31" version="1">MIFYFLIFAVTEIITLAHSKYVNLTVPEFEKIAKNNKITILTSPTCKYCLALKNTLNKMGVPYVDIELGANPLLYDLMTIVYGYKYVPAIFLCGEFIGGYDKFLEKYNLTTDDNSVFDNTFNVKKPMIQTGVVGCTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ0</accession>
    <name>A0A4Q9LXZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0700p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000700">
        <property type="protein sequence ID" value="TBU12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0700p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="21983" checksum="B06E33E080BE7D74" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEVQKCKLHPPAITLPSSSYTTITPPPPSQTCSKMQNSGLYTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWLRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY03</accession>
    <name>A0A4Q9LY03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0484p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000484">
        <property type="protein sequence ID" value="TBU13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0484p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14487" checksum="ED19D019A7A8427B" modified="2019-07-31" version="1">MPEPSPALDISLMQEILDNEYEDKRVDTRIKIDYDLLANSLGLIYKCRDGIVTKYHKSHAKRLQLPHNKTTETIYFDRRRELESGPNAEESCKSASIFAIKRYKPKININEESDLKEEEMVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY10</accession>
    <name>A0A4Q9LY10_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ALG14</name>
        <name evidence="2" type="ORF">CWI38_0691p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000691">
        <property type="protein sequence ID" value="TBU12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0691p0010"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="28491" checksum="38524E755E75ED3C" modified="2019-07-31" version="1" fragment="single">MGVNYKGGKEVEVLIIKQFVICYCVGVNYKKGSRGVNYKREGGRGVNYKKREVHVLIIRREVEVLINWRENNPTTMRNIICVLGSGGHTYEMLLILKKSWNKINKCCFILGRDDWISLENIKDMQCREGIKILQCYRPTVVKEKKIDFVFITVLVCILSISVSIFVFLFLYIFNKYKQYCLVEEYIFENINNSIYCSVFYLLRNIISDIINIFTSIQSVYVKVFYLLRNIISDIINIFTSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY56</accession>
    <name>A0A4Q9LY56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0341p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000341">
        <property type="protein sequence ID" value="TBU13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0341p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="467" mass="56159" checksum="7F8E05A09D9A496F" modified="2019-07-31" version="1" fragment="single">MNVYRYMRMNMVFNGYIFIWIYIWYKIISFEQINARKFRYRFKRNENSEILFFCCEKMSNEVLNEDYEIFFFADANLESYSEENPIFIYREDNFIQFEVLNSFLVSSASENEARNGMIQCGHELSYFLKLSKDITEMPNNLDNHQFKYMMILLKFLKAVENKNFFEFYQALICQYFFHQNDGARRNEYFDFEKIFNSNFLTRIDFSIKKNIFSTFLNSYMINYEFHDGNLILFENSRKFYDVALFDENIPFKNLLITDFRVFCILENILKDTNTRKIFKLLLNETNIKSLIINSYKGCEIFDRNLHFFILSIHTFKSIVMANFIKFSSFFISKVKAVFELNIEYLSLKNIVVSKSILGLFLKKGGLKGLVLYNVNIMEHYGFTDVYSASNETLHFIDFKNVFIGVNWWNNFFSSANVSKIILLFRSIIAEEYFLQEFKNLNRKMNVVYFKAQFCFRKISKSFIKCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY84</accession>
    <name>A0A4Q9LY84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0460p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="17440" checksum="3A143F13281B1C2B" modified="2019-07-31" version="1">MQISKLNFHRTFINEKIRIMIISSSKIFFTCLMDILALPNLKELILEPVEIIEELKNVESFQENKSISILKIIYPKVYKKSIIYDFVENLYELKYLYRYFKQKSIKYDTISLLKNRIMKKLNFLLFSNNKITNYDIFELNFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA0</accession>
    <name>A0A4Q9LYA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0349p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10890" checksum="46B161490F52584C" modified="2019-07-31" version="1">MLWPGTVLHIHSLDRLKKTVQTSFFDRQRRLDINNAIRRVEHEEITFLLKRETIEQDKTIININEELDLQEKQMVVQECDKEILTQKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA1</accession>
    <name>A0A4Q9LYA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0329p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000329">
        <property type="protein sequence ID" value="TBU14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0329p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021009098" evidence="1">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="452" mass="54235" checksum="3416107D0B4647B4" modified="2019-07-31" version="1">MKFLRKFYCLVLLYLVQFVFDSSPFNDPHIKYPYEEISKKIKLIFEKVLPKYITEYTNNELYTINLFGLDLSLNRFYIPDYISSQMYSESRIFFTEFICSKEGVLIENRNKLLFEILKSYRNEQKKINLRAYNQINGRDLEFEFISKTNTFEIVNSKSSISDLRNEILEKLKKYESHVSEHIKNKIFKIYIITPFLLKLIDINVLEYTIKELLQIHVIEKDTVILFSRQINDVQMSINKNISYNHFYQLLRKANSTGNFSVNIEKRILFNKNTYEVYQDNVSDQNDIQNGKIDDLKSRNISTISNLDLKDPMSLIQPVSKPNSDAQILPFLDQSLSFLDLSSSEERRIYREFSSFRINYIFRIFNAEIFRIKLYFQMEQNGRFRYFTLDSIFPRTKQFNQVSTIQYELATQNLQFKYYDGINHRRDSIAIFFYALNHRFEDEIESLIRLSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB1</accession>
    <name>A0A4Q9LYB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0647p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000647">
        <property type="protein sequence ID" value="TBU12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0647p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="9954" checksum="82E30559C4C61373" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNADESWERASMGVIIRAKMHEEPIPSLKEAKREEDGVKILNRNIKHPLFHKEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ1</accession>
    <name>A0A4Q9LYJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative scavenger mRNA decapping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1082p0020</name>
        <name evidence="3" type="ORF">CWI38_0454p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001082">
        <property type="protein sequence ID" value="TBU00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000454">
        <property type="protein sequence ID" value="TBU13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1082p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0454p0010"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="350" mass="41187" checksum="AAA43F5650B8CDDE" modified="2019-07-31" version="1">MEASHTEKFKNFEMSQILTNTPNYISILGRIEDDQAIILASKTNFKVENLLNSLKTFSKSKLILQNDIFLSLNVQMPEEINIKLIHPARESDIKKYSTKEIVFAHETPQMYVEDKLIKDESENNWLFNIIKLEKENKKNKKDELGNKVTEPISEPKNDAENKINAHEEYDYETEKSDTMVYRQEDSDDSDKRIKKAKMMECESNKESKEPEKELKEDIIASTDEFIILPDYKWNQISTENLYLLLIFKDTSLKTIREVTDPNILKRAKSFVIKVLKEKYQLKEQNVLMFFHYRPAYYILHLHIVNIKCPVSLSSCIGRAVLLDDIIDNLENDNNYYKNKTFHFLNFTNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN9</accession>
    <name>A0A4Q9LYN9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Transketolase</fullName>
            <ecNumber evidence="6 18">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_0414p0030</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="18">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="15">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 18">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="6 18"/>
    <dbReference type="EMBL" id="PITK01000414">
        <property type="protein sequence ID" value="TBU13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0414p0030"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000045">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 18" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="19">
        <location>
            <begin position="340"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="17">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="17">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="72548" checksum="BA53BAB832D4F77C" modified="2019-07-31" version="1">MSDILSINNIRVLCAEMVEEAKSGHPGAPLGLAPFVYILFKNYIRFDPEDSKWINRDIFIFSNGHACTLEYVIRHLCGYKIGLEDLKKFRQLGSITPGHPEFGVTDGVEASTGPLGQGISNAVGYAIALEKMKLYNKESLSIFDNRVYCIFGDGCYQEGISHEAFALAGHLKLSNLTFIYDSNKITIDGPTSLSMSDDSVLRFKSYGFEVEIIEDGDSDLKKMEEILNKKITKTKVIILNTTIGKFSELEGNAKVHGAPLGMENLKKLKEKLNFGEEKFLVKNEVKEIFKEVIQRNKENRKVWNEKIKKYRIKFPEIYEEIFRKEKTVLKISYENQSGKIATRKHFSDALNENISKFKHLIGGSADLTPSNLTKWKESEDFTAENRKGNYIRFGIREHAMMGICNGISYFGHHFVFCGTFLNFITYGFPSLRLACLTNLKVLYVMTHDSIGLGEDGPTHQPIEVLPLLRATPNLTVLRPADGRETRFCLKFAYEKDGPTVVCLSRQNLPDLNNSSIDLSYNGAYFIIESENPEIILISTGSEVCLALECAEILQKKNKKVSVVSMISFELFEKQSESYKQKILPPKVIKISIEASSTFGWQKYSNFQIGIDSFGKSAKYEDIYDYFGFTPDKLSDRILSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX1</accession>
    <name>A0A4Q9LYX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0416p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000416">
        <property type="protein sequence ID" value="TBU13487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0416p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020990846" evidence="1">
        <location>
            <begin position="25"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="543" mass="63455" checksum="1269307C0EDCBB6D" modified="2019-07-31" version="1">MINFFLLICMLVSELLNLTGIINASNSIEYINKSIIGNQTSRYLHVYCEYCKKTHLNDSYSKEESKKENECIGKILRETIKILEKLFELPVNSDNKHLKSSLENPYIYSGNDRNKTCVLFVRSEGPRISNTDQNLSERQNTFFCSTCAGYPQVNNSFSSQNYSDTDFSSRPINSFPLYEHDRISSKTNLLHCMLNKLYLEDFFTNLNDLLPFLENNYFFETITNSFTQKEHMKTLVNLAYNEINIMKVEIPEIELEQNWETFKIQYSSIKIIDYDSPLISYFPGIVHLKEFIYNLLESLPLRRRNIFNVFVGMKMIESLLVSSKEIISSINPFNTKDIFSPNSKIKKKLNEYKVTFYRILKIILCKNFKLPKEFYINLRIVDIGCARLINNGLYPFDGYNSFLRILVDSIFLLDFESTNAVSAIFEKLVFDVNLKTGFVYHSLFDLSCLKKMEFDSKIALKFVRNYLKLLQQKEFICCKNLNGIFLQSLIDSLTLEANKIEKGLTEKGSSETKEHIHLLFKCTMIFDCIIKLGFNRNIQYLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ39</accession>
    <name>A0A4Q9LZ39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0395p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000395">
        <property type="protein sequence ID" value="TBU13557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ39"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0395p0030"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001546">
        <property type="entry name" value="RNase L inhibitor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="83"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="359"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="613" mass="68714" checksum="EA529E87DD7BBB88" modified="2019-07-31" version="1">MAKNIEKSKLTRLAIVNPELCKPFECNLECKKACPINKMGKDCIVVKKDSKISQISEYLCIGCGACQKKCPFGAITIINLPTSLEKDISHRYTENGFKLHRLPVPRQGQVLGLVGTNGIGKSTALKILAGEIKPNLGKFKETPDWIEILDNYKGSELQGYFTKLLGNELESVSKIQYIDSVPKNLKKEFSNENLTVKEVLAVKDERNLKDFFLSLLSIENIIERDLEALSGGELQRFCVLLTCLKKSDIYIFDEPSSYLDVKQRLLVAKAIRSLSKADKYVIVVEHDLAILDLMCDFGCVLYGKAGAYGVITQPYSIKNAINIFLDGYVPTENMRFRQEALKFNISEKPETSGAEISYNKYDAMKKTWKGNKSGFSLNVEAGSFNNSEIIVLLGENGMGKTTMVGLIAGVIKSDDNNETFCGAKVSLKAQKILPKFQGTVRELFMSKIRVSFLDLSFITDVIKPFGIEYLYDRTVSSLSGGELQRVAITMCLGKEADIYLLDEPSAYLDSDQRIAVSKVIKRFIYNKKKTAFVVEHDLIVGTYLADKIIVFDGEPGIKGNASAPLDIVNGMNKFLKNLDITFRRDPENFRPRVNKPNSAKDREQKENNKYFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ53</accession>
    <name>A0A4Q9LZ53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0242p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000242">
        <property type="protein sequence ID" value="TBU18426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0242p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="59534" checksum="68E19B9AE7F3B18C" modified="2019-07-31" version="1">MLIQSLLATEIIRVNTESCLITDTESEEDMIYDFQKCKRQKIYNNCDNPDSEKEKKIKSNATSETVATPHLEGDKNKASFYPKITALLKGEFSYQEPQILLPPCSIQNLMDNSNQACSRKASEFSLSIDNMLLFHSKSPQKIEYVFVKMCEELHHVFSVNGIHFYTLISHIKFYLKRLELYERFYCRSSSETDLAWIFDETKKLILFQWKDFKRSLYISFFPELFGFGTFINDKYLQSDLKPFHLFRNLFIIHIICSRSRETIEEEKIYFPNKGRLYQKKNCKIILSDQETILSFLILFFESLKTDDIFIPIYLSFRSKLVSKNADESRFTNIPLKKVYFDLFFMLDVKEYVKIHVFLWNNSVDTISNKKIFAQISRYLGFDRLSFTRLDTIKWIIMYKNILTELRFYIQEINTKIAFTLHQKEFLLYYDLFVKCLIKILANEFSLDSMKILRISAKFYKCAIRFLWNVMFEKINFDLAPEFRNEINNLLNKNAIFNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK9</accession>
    <name>A0A4Q9LZK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0207p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000207">
        <property type="protein sequence ID" value="TBU19513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0207p0050"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020193065" evidence="2">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21023" checksum="364366B9C43309F3" modified="2019-07-31" version="1">MKEKYIFTRKFFLCLHLLLLNRFRFKSSNRIRSHSTGHHNYNAVKILVYRSDRFILDMKMNKITLFGLIYKSGVEIIPYVMTWDGIVTKYHNSQLKKLEIPINIEEYIQSIVPKKTVETISFDLRRGLESELNAEESAERGSMCVIMRAEMPKEPTHPPKQAKIEEDEASVGVNEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS3</accession>
    <name>A0A4Q9LZS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0187p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="637" mass="74251" checksum="B019B2FDE32AE975" modified="2019-07-31" version="1">MFLFFCDNYFKTILTNKIFIVKYSSLKYFSIKNNRLEFKLNNNENMIIELLQINNSENIKIQRKLQKKNVEYFKPESINTPKASKISQPIHDICVKKSPSNNKKVILNVSESLNNQEGINLEKENFNHSKAIQLTDNIKLKIKSNFTNNSKITPILEEINDIEGVKHQNGYFKKSLNDFDGEPHDNCKTKTNNLFFATSTELENNFGINAGNNQENKTNLQNQFKDNKLENQSLSINLQNFNSTKEENNIEELKKSVTELKNSIKESKNSNKHDNYRPNKNTTLMNTTNPPSESISNESNKNIEMNRNSRFFNKKNQLSENFSNESNKNSEASESVNSSNTTNQRNVINSDEFDFITKTNDENEDRSLNKPQSKKSLNILKSKNSFSKLPTNKYKRPKISLDSIQISKSTIEHTSSQDSCNSKYNEENKIENTEFKSSESNYKYYKKEENKIYSAKKRKEKTKKEIQNNLKTPISNTEHYKSYKEQPQSSNSLSSIKKPEEMRNPFIKQTKYLNSTDSLSSIKRTEETNNIFLNENLLHSSNSCTTDNSNNSDCLTKYISSERNLYLINDTYKSTFKEIQKYSPKFSLNFDEKLKKVVNLKIKLFKRLKKIILRNQNSKIKNLICNLNRFKNMKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV9</accession>
    <name>A0A4Q9LZV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0193p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000193">
        <property type="protein sequence ID" value="TBU19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0193p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11694" checksum="7C5723C91D4757DD" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTFEAISFDRRRGFESGLNAEESWERVNQHPFKRRDREEDGAKNFKPKNKAPIISQGGTTLEKPTNNINKESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY8</accession>
    <name>A0A4Q9LZY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0463p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000463">
        <property type="protein sequence ID" value="TBU13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0463p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="17073" checksum="5E79F2DEA8B56EF9" modified="2019-07-31" version="1">MFLIIFESNDTLKEYCTDNSTNKNIFLFKDKNHYLSNICGEEHVISNKNKSTWREKFICLENIDMKDHFPTEIHSFSYDPVLSNFKNLRIISLYNVEIPFDSFKDISIEDFKKPNLLSIGYFMKSVNSEEIVRAYSIFGSNILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C8</accession>
    <name>A0A4Q9M0C8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0406p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000406">
        <property type="protein sequence ID" value="TBU13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0406p0030"/>
    <dbReference type="OrthoDB" id="10685850at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="682" mass="78469" checksum="7BF14E79998B3890" modified="2019-07-31" version="1">MAVQYIFLIVYHIFATLNRTDSIISNETDEKNCQSNGEIISSMIPFIILNDASKIADKPNMNLNYDQIDSLASPASSSLYYSQINHQTSSVHSSHSIHNEFDGFIELANKNQNAEANVTEADSILYHPEFFIPDSTHLDEDILRDVLPVTDSAPYSNIIGAIPQLGEGNEDILRDVLPVTDSAPYSNIIGAIPQSEERNEAILRDALPVTDSATHPKIIGVIPQSEERNEDILRDVLPVTDSATNFNFIGILLHLNEKKWKLIVSLPPLVDINEEIAVKTVRTMETHSNTSSIFVQDDISFTPNHSQNDSTRLRLKRKWQTSEEVDEHMEFKHLSAIKLAHIIVETGIGEAIPCDNLTNKKNPVDIFYSKIYKYANSAEIKCSNYIFFIAKSKELYSEIYFGFQTIFPEDNTVRENNENSITRGNYEEIISKEIEEFGFGAISTDKKVNEVFIFAINLKNFEETYLSNLRSDEISNVTKKIAETMSIIQKHKNLGIFYELIKFIIYYQKNISNYIEKDCNLYFYFILSVISKQLPYFDGFQSLKYKKCLFSREKCGNDTRDLYLKKFYVQKLFSKLLLGIKNGTMRAKFYNIYIRGGVILDMKALHRIFLSVMVLQLVWPGRGGAMACHKEFIFSIYVNLFIEENIFYFENIREEILNHTLNKSRLNSFDNNIRFYVHNYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I7</accession>
    <name>A0A4Q9M0I7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0250p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000250">
        <property type="protein sequence ID" value="TBU18160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0250p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="568" mass="67497" checksum="1539162F6098D377" modified="2019-07-31" version="1">MNFFIFICKIICASEFKYTDILADSLAIDNNYLEISYEIGADDQVKKCFDKLGLDIEDERKEEMIKITSFYYKKIQEYTNNETDTFLAYITTWICYFAYRNTEVDIKRYRPEFLFNLITFKKFFEFCKKDKDMISNIKDISVKLITFRLQEDTCDDDEWWKQHYDSLKRIYPEICTNIENSSNRNNKIDIAVLENIVLEKKTDGLDSFVFDSFLVYATHEHHFSFFLGLKCMFLLGKKNEIFTPESLIKKEITTAYDIYKIFMPAISYIHKSFKNIGLESYKKLTEYISEPIFRKILKVKDDFKEIYKFSGKEDLSNIEAGDSNSSLKFIEYIVERKEINYINALYVFLKNISKTEYHEYISVVLCLKAFCFETIVTCKLKKLRSIIEILFLADVLKIEFENENKNASAINTHKAKFLGFIKKYLDEQHIEYDKNLALNNLNCCLLPQTSSILKTFISVELFTNSSWKDNYNKRYKIYCNENNQKFKKSLFDNEENIFFYVFKQEFSRLSPEERKNIFIIPVTKAPTSDNKNESKEFGIKDFLLFVLIPIVFIGGVLLGVYWYIYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L3</accession>
    <name>A0A4Q9M0L3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0348p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000348">
        <property type="protein sequence ID" value="TBU13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0348p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021017166" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="16697" checksum="DC57BAFD3B5FF837" modified="2019-07-31" version="1">MEIFYKIIALAFFLLNKIDTAVVETGTATPVVTSADTATAIPTATATPTAVSEKKEENAANPEGLSANPTTAQIGNTLDGKNAIKEGNSTTSKNATLGSNETCPENNGTSHDSSKKKNEKSNHHNDSADTNGKNDRSSKDDKNVQRATFKRAELTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R6</accession>
    <name>A0A4Q9M0R6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0331p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000331">
        <property type="protein sequence ID" value="TBU14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0331p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="6876" checksum="A2B395F51B85DD96" modified="2019-07-31" version="1">MEKSEINTNRLDRNELPCILDMLCYVSKFTCESIKILHNLEGKDSVNERYICSLDKLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T8</accession>
    <name>A0A4Q9M0T8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0358p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000358">
        <property type="protein sequence ID" value="TBU13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0T8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0358p0030"/>
    <dbReference type="OrthoDB" id="3047174at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="329" mass="37384" checksum="68C094C40AD356B1" modified="2019-07-31" version="1">MSKLNKWTTKCVTKEIRLEMKIREISYKNQGANKKNERGILRGDSLSLLLLLLCMDPLSRKLNEKYTKGTGQTDAEFHSTNHFLFIDDLKLLAKDSSTLSAMTDEAKEFLKVIGLEINKEKSATNDTCCEDTVTRLEGFSVYKYLGIIEDSRVIQTRSSFEAVQSKLIARVERLCHTRLNAINLFSAINQHAISSINYHIGVLRLEPTDLSKLDDVVRAVLVKNKIHLRPGCKERLSLLRTELGRGLHSVELRSEHMLLQLLDFLKNITNPQTEEQKSQRLRNIPKQNSEVSCARSSSSVIISPGESTTSFYQKQMNNQDGGVKQDNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B1</accession>
    <name>A0A4Q9M1B1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0072p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19694" checksum="D2DC4A7FF0293B1C" modified="2019-07-31" version="1" fragment="single">MCQHCNQSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRCNRPDIFILHKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCNVEIIPYVMTWDGIVTKYHKTYVKRLQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q9</accession>
    <name>A0A4Q9M1Q9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0265p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000265">
        <property type="protein sequence ID" value="TBU17876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0265p0060"/>
    <dbReference type="OrthoDB" id="2193106at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10802" checksum="45E4E1F99D298852" modified="2019-07-31" version="1">MPKTVSDTNQNATKIFLNVQKSENFTKLSLSKDEGQIYLLESQNNYEDIFTYLNELFDLQSFKTETVENKKVSKIDEPKRQKQSSLLNFMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z3</accession>
    <name>A0A4Q9M1Z3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0243p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000243">
        <property type="protein sequence ID" value="TBU18380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0243p0030"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="184"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="40691" checksum="0120AAE736AF3838" modified="2019-07-31" version="1">MSNSFSGKNTNEKKYDFHVGETPEGIECENDNVLKCLVEKSGTNDENLPVTTIPTLRKQKVSINDRKRIIEKTLEGYSIIVRRYLKTGLVFVDKRGGDRRSNSQAYVDLECTKTLYKLAEWVKCTFNIDVSTSTIDRALREFHYTLKRVTLVHERRNILSTIELRTNYATSFRELEVDNDDKNFVFLDEVGFSVVTRPSRGRNMRGESAYLSVTAARSRNISVVATMNKYGMIYYKIHERAVNGEDFKLFIKEINESCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPAYSPFLNPIENVFSPQLRILIYEKFNEITGEHCSSFYRKILGYLQKSEVGQVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B2</accession>
    <name>A0A4Q9M2B2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0011p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="53563" checksum="B0B384659FC2DAA9" modified="2019-07-31" version="1">MLLKDYIKIFYRKILTDGFMNKVYDECLTEISVFFENYKHVRRVNIYFICIKVFYDEIFILFKKDISSMSVDYQEKCSNIIFELKELLNTKSQSKAYKKLIETNLDVYFKELGTLKLELDFFYENDFKMELIACFNIFILHYIKSLLVFFKSFPVFAEQVIFKNHIMNYEKDNRDFKLLNHLLKKLNKANLDLETLNINYLFEFEAENSLKNIIDSAYSEMSWRKKDQPIRERLLSYFLCQICTKIEKFELEFTNQYFKSKRAHTIISECYSSLLNNEIYKKYSKIEFIFAYNFDDLFYLFSKQVLEFRLCKYIISDEFVKLLFTERIKSITKLFFSQQETDALSQIIEESFVKKLFFIYFPNMKPNLYIFIKNITPINVLHLMKDVFSKRKKYKLDEDAYQEFYIHQFVFLKKIFVDFLNEYIKKKCNSNVHFYEFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J4</accession>
    <name>A0A4Q9M2J4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0210p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0080"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="46195" checksum="9D45B1E225E22556" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIRNEKIKAVNNLENSAGEILMCDVDVAMLSERLPPPPIFHNTTHQPPSSSCQTSLVCLVDTIPSSSGTDATACGPVNGMKNLNTDAILEGNRLMVLHSILDSVTVVEQEWPRSAILAVQKRFERMPRNGWPATLRYYNEKFICTLDIDAFKKLAQNEAEREIRQEENGERRRIATCLTEPCTLTDTTDVVRTRKLPSELVDSKVLDLINRIIGDYADSCVLMTITAVARIIQAAQVCYDEATRKIESKISKLVLSKNLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N0</accession>
    <name>A0A4Q9M2N0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0007p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23009" checksum="171C3EE96853B4FF" modified="2019-07-31" version="1">MLKMRSSFKKKSNFCFNAISIYLRIFCSLISLEFASTNKYIYGFERNENSEILIFAQKKEGLLLNDDINEKYSFKIFFDVGFEIRAEKKQVFLYENGNDIKFELFDNFLAPNAPENKYKNGKIECDFELLYFLRITRDMVEFPEILNIHQVKCMLTIMRCLHIVENRNIAKFFKILMFNILFTAVIILQEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2R4</accession>
    <name>A0A4Q9M2R4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0161p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000161">
        <property type="protein sequence ID" value="TBU19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2R4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0161p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020456303" evidence="1">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9200" checksum="49D0FF971CF95962" modified="2019-07-31" version="1">MMCSFVFYILHCSVLCTTNHNINTTANAYVNSNVNVNDMYKLEKFISLRDNSVYQSFFDINTVPNNINDQIEEYGNQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Z9</accession>
    <name>A0A4Q9M2Z9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0169p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000169">
        <property type="protein sequence ID" value="TBU19931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Z9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0169p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="626" mass="73848" checksum="AA696D655A5DD6A9" modified="2019-07-31" version="1">MLLFICKFSKCFIGFINSATVSKEDNSLSVYNDQTVNSNYMTSVNARGSSECEFIKRKTKRDKLNHIIDLINKKRRLEISGQKSEWNIFNKVSPENTSSNDNSIYTFCSHKIDQLNMKTKTDTGILIDTTTSVHNESTNSLSKYKSNEETKKHRVPNLEEYHGTKYSCDAVSISNQFPNEIKIPSSYSTAEQQSIHEQINFDSKKYFLDHINTFETLCLPTSRYRNQSDELNIKAKIKGFIQNIKSFLNNIDEELPNKVHVNNTNHILTDENISDMLKEEKLFIKTSFRSDILTDIDRMFSFALKLVEYERNNKIKLQGAYLSSFINKNGFMNVLDKLKTCAEIYFLHELIAIKNIYNTGFEQNIQDGYILYTCFLFDVLFTRVETILSNMKDPTIKMSAGTKTHNRAYKQRIPILNLDIEIFFLKSIFMRILYGCKDGKNVGKIYALILLTEFRFKIYDFNNKSLKYYIPGITKLIIVYTNMIRSIKPSQSLENFTGKMLLFFRDNKVPEINLLDLDKFLVNEALEEIIDFFFQLIKEVQAEYKIRKKYKCRVNTMRSKYKWCMDIIDSNNKNIKDKKLLIDFLVFYYSQVRTFLYPKYQFEIYISYYSWNIRMNEFNNKFKYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M345</accession>
    <name>A0A4Q9M345_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0071p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M345"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0070"/>
    <dbReference type="OrthoDB" id="2192581at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14404" checksum="FBCF8CE453F7C6BA" modified="2019-07-31" version="1" fragment="single">MIKLIKNGDIVFEIQEDFVDPLTFDSYPQIIDEYIKNEKEQIFAMLLCTKKKFVYLSESIINLRYDKCILGEPLTVYLLDDPISRLSVTDIEYYILKNKIDGVNFIAVYLCNEVELYTYSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3J9</accession>
    <name>A0A4Q9M3J9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0095p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000095">
        <property type="protein sequence ID" value="TBU20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3J9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0095p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="48458" checksum="5D9EC1B05D9847CC" modified="2019-07-31" version="1">MFLLNGISYTVNDLNEKLMQMTEKIYRCKEKTLRSFSDSDFYDIELETPTLSSEMNQLICDYITSSVTKKFNIFLEYVCNKYRATYVPNNTYFFTLSKLKSNSFLFGIKYKNNEDVSLPGKKIPKVWGKKSLKYLLNCLFSVSLIFRKLYPDLIGSTGLSYKYSFDSYRFMIFDSEFCFENIIALPNKRLISPAYFIRREKNVFSTKLKVSGKLPVSHPMNDVDLIFKKSFNMFSTLKGKYRIKAAWRFGNNSLESEHEKKFNLTTFYTRKIQLLFNNYHILNSEFLSIKEYISSFKFTSSDSSDSSALPVFEREFQVHFNWQKFSYSVQFVLNECDEFTRKYTLVFNIFENYELECEVVSDNKLNIIDIVKNFKTRSSRQNYYEPTDHDIIIMRIFEELICGENNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4J2</accession>
    <name>A0A4Q9M4J2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0036p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000036">
        <property type="protein sequence ID" value="TBU20672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4J2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0036p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6802" checksum="46C69350F70B9CCB" modified="2019-07-31" version="1">METSICYKQHVCTKIQDKISILKLANISLPNSKILKYVYFTVFDSFLYKLDRKSDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4S5</accession>
    <name>A0A4Q9M4S5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative actin-like microsporidial-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0049p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4S5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0050"/>
    <dbReference type="OrthoDB" id="2194524at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17003">
        <property type="entry name" value="Actin_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="46817" checksum="BCEA271BF2C1BF07" modified="2019-07-31" version="1">MPQQNILKNFTIPTVDQITTPNKNIQSYFMKSDSSYYVQDKYKYPNYKEETDNFLTISIPTQTALIGSSLFAFEKCNLENFYNQTNINSNIFTSLNFAIKYFDTRLVLPYTSLRDVHLSLCIPDFLTRSEIIALCDYFINLRNCKSILILPVSLSLCFSLNISNGILIMEFSDYFTFTFIEDNCLVDKNIMFKNSSTKKIKPFYIEDATDFVDDFNKMKLYENRSSIYSCNLCSYKNCVRGDTICHIKTEHIVDSNCQCGEVIEDLDEHVATHFIEDFGDIVDLKSTNILENIFFMIENDLSTEKIKKICTNFIFLRNFESNENFYENFCTNLQNEINTKLSKYDVVPKFHVLEDNSLSLLAYKGTNIFSSLECSKEIVMTDKEWNSFRLRILKEKVLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M526</accession>
    <name>A0A4Q9M526_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulatory subunit of ATP-dependent 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0035p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M526"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M526"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0040"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="44272" checksum="A73955B5B1570746" modified="2019-07-31" version="1">MADKDLLKKYDTLYALIKEHEAVSKILKEKRLLFKEVNEKYEKSEKDVKAMQSVGLIIAEIVQVLPKGEFIVKTPHGPRYLVGCSKVLREKNLKVGTRVALDITTLTIVKDLNREVDPAVFLMTLESPGLTGFEFIGGLREQIREIREVVELPIKNPEIFKRVGVTPPKGVLLYGPPGTGKTLLARAVAATLDVNFIKIVSSGIIEKYIGESSRVIREMFNYARERAPCIIFMDEIDAIGGKRSQDSTSSDREVQRTLMELLNQMDGFNNLSNVKIIMATNRPDILDPALLRPGRIDRKIEIPIPNEKGRREILEIHSCEIEKGEEIDFEIIVKLSVGFNGADLRNVCTEAGLFAIRDDRDYVVQDDFVKAVRKVADYKKMETKMEYKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5C3</accession>
    <name>A0A4Q9M5C3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0024p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000024">
        <property type="protein sequence ID" value="TBU20766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0024p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="17303" checksum="F8FA6FA93C49B3C2" modified="2019-07-31" version="1">MTKDKNEIKCIKYILREFENSTIIEIMIYEKPRHPQSKDFFEGAFQDYKITERITFCFFMKNRKYHSSINCTPYEEMLRKKLKFSLKILHLINFLPNINFEVDLEVKLKDEDNIQTIDEISDNKSSNQTYDLFTVNPDLKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5U7</accession>
    <name>A0A4Q9M5U7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TatD deoxyribonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0007p0120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5U7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5U7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0120"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="276" mass="32033" checksum="4B5049FDEDA729BE" modified="2019-07-31" version="1">MIIDIAMNIADKAFQNDVENVIERTFKNNIIPFFVGTNYETSIQCINYADKYNTFSYAGIHPVNATKNKSDIKMFPLRHSKVIGIGECGLDYDRLLYTSKEDQKCIFKEQLEFKEHLYFLHSRNCHRDFMEILSDYNINGVVHSFTGTCEEMKDIIKKGLYIGINGCSLKYEENLEFIKEVPLERVLLETDAPYCKISKSYAGYKYVQTFFKENKKGIGCLKKGRNEPVNIRQVLEVFCYLKELCPLETENFLLENACKLFGSKLETLIKEKSKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JV56</accession>
    <name>A0A4V2JV56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0427p0010</name>
        <name evidence="3" type="ORF">CWI38_1542p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000427">
        <property type="protein sequence ID" value="TBU02712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001542">
        <property type="protein sequence ID" value="TBU10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JV56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0427p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1542p0020"/>
    <dbReference type="OrthoDB" id="2196005at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="110" mass="13176" checksum="9E26A3343E2BBC77" modified="2019-07-31" version="1">MEEKNKELASKNVLLKEEIKKLSDLHTELLKNNIKNNYFCNRTHMKMIAILDENIKAIEHILKDTVDFKTKLEENTNLKNDDRILKEKNKLITNEDKKPRKKRNIVTFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF2</accession>
    <name>A0A4V2JXF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1189p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001189">
        <property type="protein sequence ID" value="TBU11472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1189p0020"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="12275" checksum="CDE1776C40B7BBEC" modified="2019-07-31" version="1">MDDQAYLMLPYFYENIFSLERIFRWLEIHEKRKMSFTLQNGMYLRYLNFKSKEELQTKILSTVPVNIDFGAVYANRLRKGTECIPEYVVREEILVKHVLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG3</accession>
    <name>A0A4V2JXG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1107p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001107">
        <property type="protein sequence ID" value="TBU11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1107p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="68" mass="7901" checksum="9A03CBC06F0B0646" modified="2019-07-31" version="1">MNYYSDELGLIYTFSVEIIFYIMNMDGIGTKYHYIDSIDNTYEDSELNTQVGLERAEANIPFKKSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW2</accession>
    <name>A0A4V2JXW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0459p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000459">
        <property type="protein sequence ID" value="TBU13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0459p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20485" checksum="2021C95B1257AB49" modified="2019-07-31" version="1">MDELECHINSLHKESLIPPNEIKEILNLAVMKGLLTQQDITVIPTSPMSSSSLIHYIQLARRNFLYSNNDTLKEFSILQDLRNTTRKIIERNEMSEFTQMAADKTNELKEIVNGYIQYERKFQKTTKVSKVHLAWKIEEPVNVEMFLFGKLSSCERKIETGNTRTCPATEYVRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY8</accession>
    <name>A0A4V2JXY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0376p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000376">
        <property type="protein sequence ID" value="TBU13632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0376p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="18148" checksum="CEA188D5E1F3172F" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISFKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKFGQTVDIDVLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ4</accession>
    <name>A0A4V2JXZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0373p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000373">
        <property type="protein sequence ID" value="TBU13642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0373p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="12911" checksum="C12A266DF67DF260" modified="2019-07-31" version="1">MDVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWEIASMGVIMRAEMHEEPTPPLKEEKRENGAKNFKPKNKAPHILQEGTTLEEPTNNINEESDLEEETKVVKEVEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ7</accession>
    <name>A0A4V2JXZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0345p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000345">
        <property type="protein sequence ID" value="TBU13752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0345p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="21350" checksum="63DEE4C77AA1A6E4" modified="2019-07-31" version="1" fragment="single">KKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIHPLKEAKREVDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETEVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY10</accession>
    <name>A0A4V2JY10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0326p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000326">
        <property type="protein sequence ID" value="TBU14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0326p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="277" mass="33405" checksum="A289A10D86F579D0" modified="2019-07-31" version="1">MDLDSEDIKNKNISTEIQNNDINEDLIEKNEVRVWRGSYECFPSIILHIFIFLRKEVKIEWYYKHSCLLHSFISIVFYNEFFKRRYSVIYIIFSYTTGLFIFSLGKRYFGQKNIKYVFLFYVSFNLFYCITSYMLLRRYIKAEGILMRISVFIEKRYNVLLRTIYFLYVLLLLIPILIVFHCNNLRFRIVEKLRVSMFVVSITFLLVLYPKTLFNKVILIMLILKNLHLMLCIYFLDNSYDDGLCISNNLLICYTGIVYQTSSYIFEKYFVSDKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY82</accession>
    <name>A0A4V2JY82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0140p0020</name>
        <name evidence="2" type="ORF">CWI38_0822p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000822">
        <property type="protein sequence ID" value="TBU12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000140">
        <property type="protein sequence ID" value="TBU20053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0140p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0822p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14884" checksum="04555E410E32812F" modified="2019-07-31" version="1">MSHSVHEILNNDVKIRNNRQDIYILDKRQNTIALIEVRITSQDFLQVVETEKLRKYDLSANYLGLIMFDSAKKTAETISFDQKEDSNLDQIPKRSGRYNVEDGGKTENTKNILTSYFGWPDHCGGRSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVX8</accession>
    <name>A0A4Q9KVX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ring finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1499p0020</name>
        <name evidence="11" type="ORF">CWI38_1230p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001499">
        <property type="protein sequence ID" value="TBT99018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001230">
        <property type="protein sequence ID" value="TBU11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1499p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1230p0020"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT99018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="423" mass="48847" checksum="7135175709434CF5" modified="2019-07-31" version="1">MTADILKDKNKVKEIKSENLNENQVREMKNSNTEVRDNKNLKDKEARDNGVRDNGVRDNGIRDNGVRDKNKVQEARDNINVDNSSSDIDRPTESRERRFIFMKEEDNDIKIEHKQNIEDDDNMLVLKGKPVSMQRRVTIARGPGGIPILREIIIIETEASISSILRVLGVLFLYALLFQTVFSLWNKFHKKSCKFTIFGILWLFPPLFSIFVKDYIFFFLCASYSILILQSVYKILKKPMPKKVPRDTYKLFRSLFFTSYIGVILGHILVIGSLFKILDLLGLGIIILAISLYFGLLSREIIDVLSEIMAVNLGYYSKDGMPEKALKNDVCSICDTDFSSTSERTHTLVCGHSFHELCIKGWCFISSKEFCPCCREKVDFKSIPADLWQKSELFFSYLLDILRSFIVFCLCVVVMTMYYKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWP2</accession>
    <name>A0A4Q9KWP2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1387p0010</name>
        <name evidence="4" type="ORF">CWI38_1765p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001387">
        <property type="protein sequence ID" value="TBT99316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001765">
        <property type="protein sequence ID" value="TBU10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWP2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KWP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1387p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1765p0010"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="408"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT99316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="509" mass="58157" checksum="DF015DBEFD67AF98" modified="2019-07-31" version="1">MGDKQLSRRRKSIKIVEKDRTEQEIDKVPAAKPKEEVKKEIEDTTKNAIGMVEGEQPKESEKEKTDKESAKDEKSKPEEITKPDEKDKKVEDGIKDAKKISETNEEEKDSFEKEKSKIDADKVEEEKDNLDKESKSAKPAEESGKAISQEKEKAEDTINKEKDEKPPKDEDKKVEEDKMMKEKEEMPLKDEDKKEKEDKMKKEDEEKETVKKEESKNKDINKDVKEGTNIISDNKEKKEEMKAHNSSEEMKTDEKEAKDKSEAATAMKLSEPSEEKRDKEEKGAATTPEKKVIISEDKNKEYAVEKDENKAIDASEEEEALAQEGIKKSQESAKDKSKQGKEKRAGYLAGGLLAGGGTTGEKEVKPLVDKKLLEKDSGGEKLDKRPSDPGTQVLDPGSELQKERDDNNVSYEGEVFKRRFFCSCFWHSRHFVLTKTGTLKYYRDLNNKGKGNIPILTIMDMQRLDNMSSRHPYQIILRFADEESVMAFDDKDTRDTWALKLASVRGKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1P9</accession>
    <name>A0A4Q9L1P9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0739p0010</name>
        <name evidence="4" type="ORF">CWI38_1079p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000739">
        <property type="protein sequence ID" value="TBU01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001079">
        <property type="protein sequence ID" value="TBU11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1P9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1P9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0739p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1079p0010"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="2">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="236" mass="26736" checksum="3F9354542C0FB67B" modified="2019-07-31" version="1">MVKNYHYYNMFSPDGTLLQVEYALEAANNSIPISVVQGKNIVVCAYKKQTIELLEEHVPGKVFQVSKNVFVVITGILADIDQIIYKIKDMACSLEYKIGMPVSSDILCRSFADKMQKLIQSTGERALSFNAVFISFDNDDPVMYYTDTSAVVYPYFAVGIGEHYSRINKHLEKKYTKNMTEQETIDLAIESLSESIGAEFNPNDIAVVYFSKDLILRNLSVEQIDTALMRISEMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L931</accession>
    <name>A0A4Q9L931_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0168p0050</name>
        <name evidence="4" type="ORF">CWI38_0382p0050</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000168">
        <property type="protein sequence ID" value="TBU04218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L931"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L931"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0168p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0050"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="246" mass="29204" checksum="0714910D27448209" modified="2019-07-31" version="1">MFINKTFEYFKLLNIPLKKTYYKECIADTIRKKLNEAKQSISDLQLMLERHCLPSFNMRKRKMSEINHKKAEINLLISKIESLFLVIEKQDLPESMRSSIKHHFATKLKRNLLFYRNIQQSFLKKISSLQTFEDLDSESVQGSVQEMVTIKKSSDSQNIKKTIFHLTTLLLEMKMIIQAQSYKIDRIDFLLNQTYLHIDKTNHELVEIPKYTSKLKNSIIYALSMFVFLLIILSILKAYKIRKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCZ4</accession>
    <name>A0A4Q9LCZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1523p0010</name>
        <name evidence="4" type="ORF">CWI38_2711p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001523">
        <property type="protein sequence ID" value="TBT98954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002711">
        <property type="protein sequence ID" value="TBU05757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCZ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1523p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2711p0010"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000057">
        <property type="entry name" value="Cyclin N-terminal domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="206" mass="24620" checksum="9B9333FEF2230088" modified="2019-07-31" version="1">MKRLFQDITNVIKKNIKLTIHRNNHRKKLIQWLYEVCTEFSYSPITYTLCVQILDKYTSLTPINYKIYQLIGITCLFISAKIEESTTKDIHEYITVTDNSVSLQQILNTEKDILCNLNFNLFFISPHSYINIFYLENISYKYNISIEHTSHLLHCFVASVMEKEEVNMYWLYEEAKTLFEKCLEKKEIDKEIRLYIPLYNKDIIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFQ0</accession>
    <name>A0A4Q9LFQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS_1-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2502p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002502">
        <property type="protein sequence ID" value="TBU06817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2502p0010"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU06817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="41016" checksum="D1499A2B41063CC5" modified="2019-07-31" version="1">MLMYLILCNAIPPILDRITLQYLHHMNVGSKTYGRQRMWGTVGYVISNIITEKITKPTSTSDDITSEGKDSSKDRNFDTLRPYHIITTILSSLGTFFLFKSINTEGQRSTRDIESGWKDLLRNKAYMFFILIILLNGITRSAMTTYLTIYQSEILELKGYSIPEHWPGFIKTIINIFNENPLATSSFFATIMCPPHLKSTSQMIYSGTFTGLSSIFAGLIFGQIFAKKKLQDKDVSMDYKVSTYQRFYLVNLIVSALSILLFVVKYGLRDRVLTWEPFRWRRETGDEAKRDVEAYVVEVNKKEHHNESTEALQNEITGKDVLDMCVSNVLVVSVSNVLVVRYGVSIDMSYTSSVGGQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFZ7</accession>
    <name>A0A4Q9LFZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2473p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002473">
        <property type="protein sequence ID" value="TBU06988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2473p0010"/>
    <dbReference type="OrthoDB" id="2194105at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="23865" checksum="B5B54904DBCBDB57" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLSFSSYTTITPPPPSQTCSKMQNSELDILPSPNAPVPSSVEVSACEPSYDMTSPCNRLMALRMIFDSVTADPKEWPRIVFLQYSKKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTMEYINLRDKFLSKIKEISMKEIGKVVVRTRKHPNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH41</accession>
    <name>A0A4Q9LH41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2411p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002411">
        <property type="protein sequence ID" value="TBU07364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH41"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LH41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2411p0010"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU07364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="506" mass="56663" checksum="1FC8D3F2E163A228" modified="2019-07-31" version="1" fragment="single">DNTTSNPYDNTTSNPYDNTLLTTTSPLSNLNVYSSSISYNVLPLKNIKEGFICKWNNNNKLAIGTTNGVIIINNSIKEERGVSNSVYGLNGVIDNVEGCRGVNMSTIEQQGVNNSTNEQQGVINLYNEQHPLNNSTNNYHPLNNSTNNYHPLNNSTNIYHPLNNSTNNYHPFTTCTTHSEVTSLCWVDKDILCCGTYKGEVRIYGLKDDKQHNHNNIDNMMDRMDNNTNTISNTNTISNTNTNTNTISNTNTNTNTITNTNSITNTVEGVIYKSYFFHKGPVFSIKEKEGIIITGCYDGRVGMIDIKGDYYKYFKVHTNSVFDLDFLDNERVVSCSSDYNISVINTRKGCWNIIKGHEGEVNSICCKGGVILSSSDDKSVRLWDVDRDKSCIFKGHLKAVYNSKWVEEDIGSCSGDGSVRIWDVEKGCCKDIYSHNKGVLNIEWCDDKRVLASGCVEGRVIFWDLRVGKVGEFKMGKSVQDMSFNGDLLCLCCSESEPVILNLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI53</accession>
    <name>A0A4Q9LI53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0091p0040</name>
        <name evidence="3" type="ORF">CWI38_2369p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000091">
        <property type="protein sequence ID" value="TBU04763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002369">
        <property type="protein sequence ID" value="TBU07657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0091p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2369p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="175" mass="20004" checksum="8AB18F1C51D12EA6" modified="2019-07-31" version="1">MFFSSMNQQFRESENSLPTYEQVCGDTPATTTTLDTGRANNRFTQGQSVISSGAIGINLESGLQPRNTGILAPPENSSFSDEVVSWFNLYLSKILYFSYIFVLIELINLKYLHYARISNILIIYQAILILILISYWMTKTRKKLGLFESSFIFLISTVLYAFFDLIYSIRSSHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJT9</accession>
    <name>A0A4Q9LJT9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2256p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002256">
        <property type="protein sequence ID" value="TBU08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2256p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="36149" checksum="1693F2CCEFF2E119" modified="2019-07-31" version="1">MASSTFSDFSEELLKSPKSNEVKKAPPNTTKSQPKIEIVKTTITSKLPCPFCFSYNTSYKGLGKNPRDPRTYCNNCRRSYSTKLGQNLQKVMNENQTQKITKPENNSLEIRTELPQNRAINISSVEKIENITNLKLEQQKKLSRITKEQIALVISGLPIFPKNNYIFLHFTNIKPNRIRYYKLALRSLNENILKNISNLDFINENTLEVICKEDSKQEIIKTFEEFPAKYVNKHPDLNEDGLLNIKAIKERMKKISKREKLINIRLKRFATKINMLEGTKLIEFLRTTGIKAIDTCTYDNSKLSKTKANVSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN17</accession>
    <name>A0A4Q9LN17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2113p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002113">
        <property type="protein sequence ID" value="TBU09803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2113p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1245" mass="148893" checksum="C3776EE240AA35FB" modified="2019-07-31" version="1" fragment="single">KFELEYLFSRDIDFKKISFSDMSIFLPFILNNSTVFELYLLSIDFEQLCSLVTSFHEVLTFTCENFDQTLSLLRSINIYEETVLYWVKFFRKTQFYISSENNFSIFFVLKDTECIQNIFIGIIENNVLPEHLRDKIFAYVFTNLEEEAKLNLTNSMKYLKNMYDHFISDNLVVSIVTIKNMLSFCDLIVRKQLVTQFPFILEHIAKFYATHIELSLILYNFYSYHEYLKSHISSIVNSFESINFDLKPFEKYVINKDTQQIEVFKNFNFIKRIQSWDKFSIKLHKYLRRHGKNFCIEFMIYHDFFLKNLLELIDHILTFKNITIAYFNINQLSFFLKRDNDLFLSKNILLIWNISIKICEKLELDFLDFFFTQFIDLFDKNAIKSSKNENLKFSWNDEYDSFCFLYTVCVSFQFLHDSIIYDLKYAKIGTNNYKLIQLIEKGYFCVYKRENYLILQEESNIISKEIIDRKIKNIRESGGEIENILGKTSYLYILIAISKIPLNLVYPPSITNPFKILFLHLIYNILNMNMEYDENLIYVLYLNILEFKSAIIFNDLNEYIRILDILLIKTINFNSKTNIDIKNSIDIFFEILFNLMNKLNNKNETEALDGFELIISSMTSKSKYISCENFKEFFNKKILKLNKIENFLKRDYILQNIFSLIELIDKNSKNPLVNESEIQENTVLIDFLENFICNLNCIDFFIDAQKQHMPFFLFIHKRINKYDSISAQGFHKDIPISDIFSLYIVNINIMISRRYNMTYKKEALFIKDIETCFGKPKEMYLYLITLLRFSEYTRLFTKKEVYTYFDIKKVISATQKHQKSVDKLGGDLLLHTFAYLDNIFEDEFYFIEKITYMFNLKHEIHNDYLNYISTRLDSIGVNKDSVENYELMYKSEFDLKTRIASEIFKCTLDECSLSIVFLQFLKELYFKYSFLVSTIDKSVIHNLFNKFGMFEELDDTISNTNQEFWCKNFYFGNFIAIIFYRGSFEFVYELILDFCVNLEAYKDESEFFSYLSLIHRIILSEICCCKYTCHTYIFNNVAHEAECEHIFKERRKDIVRNFINRDIVSILSRFTGFRKEKSKNSNLQSYIVILTDIFISFCENENIEFNNKCVIKNPFILVSYVPMKICIPRVLERIQSLKIYKLEYEPTTKSIFYNKVVVPEIMKSAYLDFGYTSGFDMKSKNISSYGQYQIFDTSPIYTSDNLSYSAKIYNHIYNLEFNLNFEEKVIFVDKIKKRLDDIIQNKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPH3</accession>
    <name>A0A4Q9LPH3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_2025p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002025">
        <property type="protein sequence ID" value="TBU10097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2025p0010"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="43237" checksum="49B4A69CA5DBBA22" modified="2019-07-31" version="1">MLIDNTTYGSSIYIQSLPSLFISLVGLALAGNCLDKALKTSSIQYYPILLISNCILNFKGNAELIYALHISSLSNSTSCSLKKYIRYSFDNSCLLLSQSIIIGLTVGLIGIAKNIFSYPLVFKNLIRILPICLVSCTLSTAFIVVLLIVAIGITKKCNINPDNVVLPTISSFGEYLAVYSLTFFTSRFNNLDLVSCYVIILIMIVILPLPIYLSIISTYRIPLQSFEILLTTYILSSISGIAVQFFSKKHNVLASTIPVFCGLTCSISYIYLSKTVTSLQYERPHNRKQSFVSLIVISLVSSIFYVTLSYFVLIRYSTAFMVLFVVFFVVDVCLLLRMVECAASRLNQRELGVFTLPLLTSSSDFLGSILLIFIVEIIYVFETTYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ8</accession>
    <name>A0A4Q9LPJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1824p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001824">
        <property type="protein sequence ID" value="TBU10358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1824p0010"/>
    <dbReference type="OrthoDB" id="2233964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="418" mass="49308" checksum="8B703BC8847B1410" modified="2019-07-31" version="1">MNISHEESNRSMKYDLDTNVLPFNKAYPETKGFLNTSDSCPVKESQYLDMKYFSEIIDTRGKNYAIFEKPATEVIELSDIELLIEGDFSIERYFLNTDYLPFYNLIDRISAIEKKFWSQIRENLIMEYLARKIIESVMKYDFCKQNSPLLSYFPSIVHIKYFIRNIIFKDINFVEDSCLWILLLRAIESLCNLQPNEVINNIKDKGIEAVDIYKDFDVYYVDKDAFLGLKPENIKNEKIKFVDSQNNNAKRIKLCKVGTSPVCLVESIPSSSHIDVFKRLTQNEAQKEIRQEKKEERRRIATYFTESCLSERLQSKNGVNGEKIVSFWSTMWNKNEDKVTYDENFIPFALTCRIPKSTPLKGFDYRLMTCMSNMYHLRKRFVTKVVPIESIEERAKAKEKYLLNISLNKEYRNNRKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPW2</accession>
    <name>A0A4Q9LPW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2034p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002034">
        <property type="protein sequence ID" value="TBU10086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2034p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="279" mass="33839" checksum="5406E806AA5DB3CA" modified="2019-07-31" version="1" fragment="single">MYFQKEFKKEYLLYSIFLVWILIHIYEMIGTVMYKQKIQSGKNPFSELKMVTNWIENDRDVFFKMQSEHSNKKILYLNSHILIVILQLFIFSFFINDKYRNKIIGFIERKRIFEKNMFFIRSLDLCCIVMISFCAFIVDLIYLTRIYGIPNDISQAVGYARYLIIPFFYIILYFFFYKYGRLPMYLIIGVLLLIQQSFIKSLLFRNIDKLLQNYENFDINLFDDKIKRKLNEFNIEDNVYISKNPNVIKNMGVVKYFTRILVLIQGNKREYENNPKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ52</accession>
    <name>A0A4Q9LQ52_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1964p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001964">
        <property type="protein sequence ID" value="TBU10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1964p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="48113" checksum="BCA9A581D8D5608B" modified="2019-07-31" version="1">MLNLELLKNKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAIFKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGMCQHCNQSRKTVDHLATKCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQA6</accession>
    <name>A0A4Q9LQA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1694p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001694">
        <property type="protein sequence ID" value="TBU10534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1694p0010"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17139" checksum="0B167EAEBF6EB5E8" modified="2019-07-31" version="1" fragment="single">LGLIYKCSVEIISYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN9</accession>
    <name>A0A4Q9LQN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1550p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001550">
        <property type="protein sequence ID" value="TBU10788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1550p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="32701" checksum="E7B72896F9EEF1AB" modified="2019-07-31" version="1">MSNPGTQQSSQTSGGNNSFEDRNLFKLLVFLLLLSGMILVSVVVVYGNIKSLRKTKKIKEEDNVKDQGGFEKNIEQIPGENKSKPRESNKPEQDTDEYKKDRQGDNDTNEIEREGQEEYVTKEKQDEGTEYEEQEAKFNEEEKIKKMEKEGIKSQVAILHQVVKLKNNKTQKDKNGKNMQVSVEKKSDLLLEHGKEGEIYNGAENAKIKAANENENANIELSVEEKIDIPKNMEDEDFIEILKSVVGEQLNEIKSLKQYERKDIANVNATKQTVDNISEQGTKEQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR8</accession>
    <name>A0A4Q9LQR8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1516p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001516">
        <property type="protein sequence ID" value="TBU10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1516p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="30326" checksum="CC88D896E151E881" modified="2019-07-31" version="1">MNSSRFLTYMFNKIITDKEIPLIWKKHMIQPIHKDDSEFRPISLIEKTRKLFEKLIFSKFEHSTLNHALTLDTRLRHSDVEGICVTLDFSKAYDSVYRKRLYEKLMIKKKFSREDTILIAALIENNESYTEEKKLLRWIFKPNKSKNLKNLKKNIKYIKNKIQGNEFKAKYNRWQKENLRFNSQIFYSFENLRQYNFKRIPTTRFKSFLDIIRPEHKRENIIEILIKFIQHNIGHPTNGVNIGLINPQDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX4</accession>
    <name>A0A4Q9LQX4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 9">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1482p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001482">
        <property type="protein sequence ID" value="TBU10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1482p0030"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="11">
        <location>
            <begin position="241"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="686" mass="78099" checksum="8797BBEC178032EB" modified="2019-07-31" version="1">MFLDEDIKITPLGAGNEVGRSCIHIAYKETSILLDCGVHPAYTGLSSLPFIDKIDLSKVSAILITHFHLDHAGGLPFFTEKTNFRGKVYATHPTKVILKYLLNDYIRIINASSDTDFYTERDLKSCIDKIIPIDYHQEIDIHKFKITPLNAGHVLGAAMFILEINKTKILYTGDFSREEDRHLKSAELPSFPLNILITESTYGVQCHLPRCDREQRFTSTIHNTIKRNGKVLLPVFALGRAQELLLILEEYWNNTPSLQYIPIYYASALAKKCLTVYQTYIHMMNDKIKIQALTKNPFIFKHIHNLKGIEHYEDKGPCVMMASPGMLQSGLSRELFEMWCEDSNNHTIIPGYCVQGTLAKEILTEPEEIDSIKGSKLKLRMGVSYISFSAHVDFIQNAEFIEHCSPQHLFLVHGEFTEMSRLKSALAHRAAQRNVEMQIYTPKNCETTAIQITGERTVKIVGEVKEESIIEGIIIASGRGEVRIVKRGGESIENKRINMLENKITEITEITETNQITNEMKDKPTNEISENKSINLKDKISEIKVIQRVIITTNINNSVIKSTLLDFFSNSYVKDKNIWIGDIKVNLEEESIILEWNSNYINDVMGSTVGRVIEDVSKKITCCLGKEEALIKVLRNYFYVEQNDGDILCQGVRICLRNGSFSVENGEERIREKVRGIVERVGFIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR82</accession>
    <name>A0A4Q9LR82_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLO box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1666p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001666">
        <property type="protein sequence ID" value="TBU10586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR82"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1666p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLO box" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42582" checksum="B181676FE1732F32" modified="2019-07-31" version="1" fragment="single">INNHSNHKNNENTNNILKNSNKPISMIERFYISLKDKLYEELTCTYDYVTFSIPISRYRVIGYNMSSGRCGVYFSDHTNMVLEVCNKKVLYLSVSKEENKKVYCSEEHLIGRVPDILCEKYEVLKYYVKNFGINNKEGNYSNYSNYNNCKDNNGFGYNYKDCKDNNYKDSKDINCNNYKENLYNNNIGVNDRSFVMRVKRVENGLLFGQFNNIFVFDFVDGNRVVIYDKGRKVYCCDVKGVKKMTENMRVFCMGVLESQIKKVLNNKYILLLVKGVITIGSDLYVVNRVLNKEVFLMVNRVLNKEDLYVVNRVLNNKYILLLVKGGITICKVFQMVNRVLNNEYITNNISCYQQSYYQHIMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ0</accession>
    <name>A0A4Q9LRJ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1330p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001330">
        <property type="protein sequence ID" value="TBU11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1330p0020"/>
    <dbReference type="OrthoDB" id="2199512at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14741" checksum="8782FE6042933962" modified="2019-07-31" version="1">MYRLNPQKVIDIVKRCLKIDLVFVEKNGGDGVDSECTKTLYDKGRNMKGESAYLSVTAARSRNISVVAAMNKYSMIYYKIHERAGNREDFKLSIKYIYESCQRQGISTPNFVIDNARIHHYLGSNDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL5</accession>
    <name>A0A4Q9LRL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1400p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001400">
        <property type="protein sequence ID" value="TBU11074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1400p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="498" mass="59584" checksum="992D265295C09643" modified="2019-07-31" version="1" fragment="single">MKSECNNSGFYRKTFIFNVILYILNSVLEKLNTKIFCTEVNFYFIHEKYVEEIISTKRLHTMRIPICNQLREYETACLLENRVIMCNSTFNKVEYFSYKIFSIEYPKDLILESNLIESYIKSGETTIHIFLGNFSILSSMKFFKLISSLDGFISQIQLNEFIQYTKFLSIFKMNRTENRKYFLKNFVLHVIMDPGFLEKNYYFLTTVYDKYEDLDKELINEIFNIFLYFNLVKQKKESCLFSPKIGPMYSPEIKLNFLTYEYLTEKYNKFTILQITDDDLKSIFNVMDHDTFIARFHFLLRMMNIDVLFINISEISEKILISYFKIKPNKLTKIYFVENGSDQYILDILISTNYFDGIDNVKIYSEFEIEKIDYIVKMCVRCKKIKVSNVIYFEKTVKTLLKFAEENKNISVKYQIQRFIITFGNLILLQDIPENMIVVVGQVNFEILAYIRLEFICIYDFIKNIEITFRKDKAWQELILKCKNVKSLFLISEDMKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM8</accession>
    <name>A0A4Q9LRM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1334p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001334">
        <property type="protein sequence ID" value="TBU11188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1334p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14904" checksum="970E05BFB02B799D" modified="2019-07-31" version="1">MELNELDKNDWLDFKNENIKIKMKDLNRNITVVEQKNLYGFTVNTFKEYKRYLRRRLIRNKISKNGCVTIIDKEFTKLDSFMSWINFIIGFLIFFTFKSVRNITFSVKNIYLYIIKRYSCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP8</accession>
    <name>A0A4Q9LRP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1378p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001378">
        <property type="protein sequence ID" value="TBU11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1378p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020475579" evidence="1">
        <location>
            <begin position="20"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="663" mass="77697" checksum="74A0D8C8A188D041" modified="2019-07-31" version="1">MNLNFSLFLIHIYFNAVEASPDRKKVKISDHEENSFKNHETLAIIDGIDYLGFAKIFSHQSKPLISSNPIEGAISSDRREISNATGSDSKTYIDEPQLTELDTKAQEEYSLTFQAFSAKRFYDQKFTEADSYEDMSQKGSQLEFSFDDVSSYMELNSTEKVQEFHCEIYPNDFEVNRSITSGTNTNKTSLSIHQTIGKNNAVNDSSKFDLEFQSKDTNGSDNWKEAVNKLFIKGLIENSGSNMREELISIVKDELEKKIEEQDRQSDVDSEEEVLSCLKNKESKFYCNKFKSNSDFKEILNFGRRLVSFEKNSYSNLSTSEIMQKIDGYHLINYANELRKTKIHLIVPELNYLLDSFEENIIDNILHGNALLIHYYYEITKIIINLILTNSNKVDINIIRKNSRGNEKMEGKEEKSGKISKEEKKKKTLDESEEVRLLDIRRIFFIKRLLSELFPLFQYDSVKIEIYKTLNLLYFISHFIHLSRSYLRKYFFRYKMNFLFRFLFDSNIYFKNDFNKKFIEDILGENENGTNPDLFIKNKLTALFRDYFCLDIFFYKGIAIIETYKVFAIAKDKDKLRTKTNIIAKLKEDSEQNLLENIDAYKNRKINIFLKLEFEINHSEYLVLSTTISIMNFYKSRGPCEISKKLLKESNKSLEELKFNKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR6</accession>
    <name>A0A4Q9LRR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1326p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001326">
        <property type="protein sequence ID" value="TBU11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1326p0020"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="22931" checksum="9BD2124C74D840D9" modified="2019-07-31" version="1">MLENDRKENFRDRDEKCSFYYRVGACRHGEACEKKHMPPVRSYSVLIKNLYFFPSHNPECTMTELAIQEHLELFYEDFFTEIGITYGYIIDMVIALNISDHLLGNIYIKFSREEEAIKCVEKLNTRFYADRLICVELCHVDNLIKACCKEFENLECLRAGFCNFIHRAKISQELLDELYDAQEIMYEMKNRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS51</accession>
    <name>A0A4Q9LS51_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1473p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001473">
        <property type="protein sequence ID" value="TBU10926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS51"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1473p0020"/>
    <dbReference type="OrthoDB" id="2192720at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="60400" checksum="D30918A74A55C55B" modified="2019-07-31" version="1" fragment="single">MKQRYSIVQLSETNKPKTQIYTSKDCVTLGRALNNDLRVQQNGIENKHLEMNLKNKTLLAYGSDVKINDFPVSTNTITSFNFNDKISIKDTHFSVQIDETNDDGVGDKSTLSNLVDTPFFSPSPLKFNPSPQKPRRSVEPHPSVLTPSYDQSTTTSDYNLYLQPPVRNVKQTSSDFLDVSQPKLNHEESFLAQTEDGLSSEIKHDFNKEIGVLESPVERMVDGLSSEIKNDLNKEIGILENPLEKTVDEFLEKKEIILENILTKSEILDSNLDSKNEKNVSKIPGIFSKSDELNILNNAINEENSDGIVTIKRETVTETINNGTKEVTKEVIEEIVETETKTFFGLEEAIDREAKRVDEEIKSNVEKITEGSVNIPVSPEMVKHPHIDLHAAVLEKNILKNAKDVLEEEVRDKVEIERSLKDRESMESNKIFQLQPSIEILESESLEGSNLITKRLSDGDEKIPDLRIKRIKKEEGDEILEEDDSKITKDIITEPIIEEIPMKNDVEEVEKELEYKEEGPKSTLEVFEEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS77</accession>
    <name>A0A4Q9LS77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1685p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001685">
        <property type="protein sequence ID" value="TBU10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS77"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1685p0010"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15535" checksum="F8B597A200B67C7F" modified="2019-07-31" version="1">MSKYMTTYKKNDLVDIKVNPAIHKGMPHKFYHGRTGKVVGVNPRSLVVILNKTVGNKQIRRTLYVREEHVSKSRCNEDFIARRTTNDEIRQQAVLEGKKVKCLKRQLPGPRESFVVSMVNNTPVSLGYEPYVDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS82</accession>
    <name>A0A4Q9LS82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1214p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001214">
        <property type="protein sequence ID" value="TBU11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS82"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1214p0020"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="509" mass="58920" checksum="65C33FEACA9B294F" modified="2019-07-31" version="1">MAREKLYHLKSEHTESFSTPKTPSKKQAFRHHSISIPSFQLNRNVQPLDVPELTSSDINEHTSNSTTPFYTPHRFSKQKNCQILYFNGSLNFLNLQINSIEEKFIFHKKIGEGDFSEVFCVQRIFDSSVMTPSTDPSSFTKKYCKRKNSEEPLKVEPLKINAKICKKNDFSFLDDNPFICSKSVPRKNKTRYNRENNNRKIKRVKYMDSSFIDSSVVLGVNNGESFSNENLKNNLNFSCIKKYLRKYSGETDRLAKLMEVKILYELLYCENIISIISAYEVDSTLFIETEYCNLGSLRDFINYVYCDKKSNFVAEIVHKIMIEVGSALKFMHGLSIVHGDLKPENIFLKGNLNSFLEQEITDLNENGILDFQEEKEIFFSKMNTEFFSDKYIFKVGDFNISKYEDSSVEEDGDKKYMAPETLDGIGVCSSDIYSFGLIYLEILRGIVLPDGGITWSRLRNNNFYGLKLAGLSGWERRMVVQMIDKEYKVRPSAEEIVKIFDEHKNVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH4</accession>
    <name>A0A4Q9LSH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1163p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001163">
        <property type="protein sequence ID" value="TBU11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1163p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6100" checksum="D582BF276B1F165A" modified="2019-07-31" version="1">METKKTPTLERISQESAARKIFRSEPEIKKYHEKELIWCDEECKKTQSIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI6</accession>
    <name>A0A4Q9LSI6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1393p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001393">
        <property type="protein sequence ID" value="TBU11086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1393p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020266310" description="Macro domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="153"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="40001" checksum="A70950D0CABF0563" modified="2019-07-31" version="1">MIIAVILIIGSLGLIQFIRTRSKDGSSSNDKKNTAKENEKKSDNTKKQMKTHEINVEEENPLPEEKNVPPKEEEKKQEEEKQEEKKQEEKKEEVKQEEKKQEEEKQEEKKQEEEITQEKLDKQFDLVNQFRGMFLSNISLPTLKTEFKAMIVNTLGLRVSNIKMNSKLKYKDLIKAFNLGLDKICIVNAANESYHIDGDGLNAGLTEFAKSNGGLNLEKNQWKNLTDKDNKPVRVPVLSGSYAISDFNNGIIIHGVGPKACEVGKTPKEPKNLLEVKHRITDLYNNIYIEALKRGSALIIFPKISGDIYANPGEDQSFTKTTYLNAVYSGIIDFLKKIKVEDRKILVFNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK5</accession>
    <name>A0A4Q9LSK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1694p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001694">
        <property type="protein sequence ID" value="TBU10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1694p0020"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14518" checksum="849FDBF7BF09B93B" modified="2019-07-31" version="1" fragment="single">YHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP8</accession>
    <name>A0A4Q9LSP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1184p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001184">
        <property type="protein sequence ID" value="TBU11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1184p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="26155" checksum="14C97375B7E66645" modified="2019-07-31" version="1" fragment="single">SVSEKIEYIAKNFTIENENLASTDTIYLLVNKKMDLSERCGLCHLLNQYFESFGKQNRYLYILMENITQKKPKKIVDFISEKKDDIHISFFIFNFKNLVYDLNTKSNVKKPTFSYNKKFHSILMCSYWEDKKPKTRFLYIGFEILLNNMTRPKKIYEIEIKENNTSHISKENPIIFKHRVNLVFFYDYLVECSYISYDEKNPAIRIKMLDFLSLKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT86</accession>
    <name>A0A4Q9LT86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1026p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001026">
        <property type="protein sequence ID" value="TBU11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT86"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1026p0020"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="120"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="467"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="682" mass="78929" checksum="AEEF367E16E4EB45" modified="2019-07-31" version="1">MFDITHHLNTKCPFTHKYVTKLLSFPFKDREHATQSLKQYITDSSLSLVLDRLRYTPFNYAVIPLDKPFTFSSKEENLKNLEKQKKEIKKENLNIFKSREDDISDSDSFFENYFINTSSIKIDTFDLWSFGHCILKDTSLTLLPNTRYGLVGRNGVGKSTFLFALKNRQISFKKMKVHLVKQEHYGGNLTVLETVLNTRISQNLSLCSNYKEIEKNLEILAAENKFENKKIQIEYLIKLFQGFEFPPEFIFSKTNTLSGGWISKTHLVRGLYAKPDILLLDEPTNMLDLFSLLFLQMVLVTLECTVIVVSHDMNFLECCDSIIHMESNSLNFYKGNFSCFVEQKNLKNEENIRNYNKQVKDREHLQAFVDRFRYNAKRASQAQSRLKILNKMEILQVPVSVSKMKYKFLSEIETDGFKEMMRLKGVSVGYANRENRENNKDFKNNENENKDFKNSEIRNNKDRYNEDKNQGTNRENQIKTVLTDLDISINNKSRVVIVGSNGCGKSTLLKVICNKNEDVLRVWGGNVTYGSGTKVCLFSQCHVDNLPYDVPVLNFFMNMGYTQDTVRSELCNFGLVCENQLIGSLSGGQKSKVVFCLLSLSKPDLLVLDEPTNHLDMESIEALSLALQDYKGGIVCVSHDIWFVEKVFKEVWIVENSKLRVYEGDIKQYKDSVIRNIKNKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTB4</accession>
    <name>A0A4Q9LTB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1011p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001011">
        <property type="protein sequence ID" value="TBU11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1011p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17027" checksum="45E6CA81F46D2263" modified="2019-07-31" version="1" fragment="single">LIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVEIISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG5</accession>
    <name>A0A4Q9LTG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1127p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001127">
        <property type="protein sequence ID" value="TBU11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1127p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="17549" checksum="F90B11C03C1F08B1" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMTLRTIFDSVTADPKEWLRIVFFAVQTRFERMPRNGWTELHRYYNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL8</accession>
    <name>A0A4Q9LTL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sof1 domain-containing U3 snoRNP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0273p0010</name>
        <name evidence="9" type="ORF">CWI38_0958p0010</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000958">
        <property type="protein sequence ID" value="TBU11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000273">
        <property type="protein sequence ID" value="TBU17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0273p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0958p0010"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="8">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="49640" checksum="F231E542492BD517" modified="2019-07-31" version="1">MKINTITRDYRDTVKERKNDINKRSFTKDSLHHPFSKEREYIRALNATKIERLFAKPFLYALSDHKEGIKGIELHGDSVISYSFDNSAILWSLDEKRKIWTFDMEKTILSADINDRGMCITQGNELFYYSKIKEDESIKKEIKVKHKFSCDGMFNCVKLQEELCCATTNGLEIFDFEKKKSAIQLGKESFHGCFLSNKQPNIILCTFSNEIYLFDKRENKSVGKIENGIKTNEICCNQMRENVFISANEDTNLYLHDLRYLSKPTTTYRNHVNSVLSVDFKPNGEEFISGSYDKTIRIFRTDDCRSRDVYYNQRMQNVYGVRYSECGMFVVSGSDDGSLRVWKSNASHKEGKLTRREKESLKYSEILKEKFSDFPEIKQISKHRFLPKKLRNEMKDTHFHYKADERKKALYEEKRNLKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX1</accession>
    <name>A0A4Q9LTX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1431p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001431">
        <property type="protein sequence ID" value="TBU11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1431p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="20229" checksum="94C7CF6D6685E485" modified="2019-07-31" version="1">MGKILVKRINGEEYYFAKDLVKTDKKNISTNSPNEENTNSFYDTQQSNITFSDSKEFTDVLFIKKELQELTGIKPEDQILIKCKDYFLLSVKNVKNENIFDENEHKGETVESFNSEFHQKINISLQKNNFDENEILNLFSDSFLSEMKDPNNFLQLFSDEWTYINEEYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU09</accession>
    <name>A0A4Q9LU09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1412p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001412">
        <property type="protein sequence ID" value="TBU11050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1412p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="8297" checksum="6B7E619502E5C4AD" modified="2019-07-31" version="1">MLFKIDSENIIKVLKETEDSVKNSDIDMIEVENFYNDNCIKIDTTTFKANKYEKQYYGEELEKFQFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU38</accession>
    <name>A0A4Q9LU38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0875p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000875">
        <property type="protein sequence ID" value="TBU12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LU38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0875p0030"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="645"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="957"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1401" mass="161459" checksum="8F9F4687BCE01620" modified="2019-07-31" version="1" fragment="single">MTDENNFFQKNIPTFTEVSSHFPGMGTLLIKGESLIHHIKNQYSLTYTHLPLLTYKHALKILFENLFQANFTDITVIFFLDETEDIYIECIKEFTKKIIKKNKKLKMHEIFFKDFTDFLSEQRVALTLTDTDISSLNYLKHCLNIDIYTGLMINMEFKVSSVSLFVYRPFKTNFILKFFKKENKKNKISFLEIEEEIFKQNKNFNLEKIKFICEENLSNFSYFKSTQKQISESLCMAVRKEIKEKEDFIFDGRILVNDSIPEEEYDKENINKSYTSFNNTDGNTDADGYIGGYIDGYNIGNTGGYNIGNTGGYTSNNTTTTNNTSTNTNKHITTNTITTKTTNTILTNTTNTITTNTIDDLYVDTLIIPAVPSVKNSLELSITKRDDRPRKNTQYYSQHLKKAAMSLFGGKLLYNPIKRLSKQNEKPEKKSKKQIQFIKENEKKLETEKRKKELIFLKSFHAKYLNLDTESKKIYLENFMEGGFSDSVVKKIILLKIEFYFDLWSLEKRKEEINEKVLIPCYLNCLNFIDRFISDPEKFKNISNLEMEFVFQKLIDCGFESTALELLHKYNLIDSSFESSTIELLHKYNLSLNLTFTSQKISKKPNDLDIYFQLKFAGDKLKRTLDSVKDKRVLFEPDKWQVDLLNLVDENRSAVVSAPTSSGKTFICFYAIEKVLRESDEGIVIFCLPTKALVNQVAADVYARFVTKVYSKKNMVLQGILMKDYQIDPYNCQVLITVPSMLESLLKSPPQNYIKNLKYIIIDEIHKISSEEMGIHIERIIHLSPCPLLVLSATIGNLNNFYNWIKNIENLKNRKCNLVIHKERYCDLKMYIFNNSLIPINPLFAYSVSYIKLHGKINTDLNFLPEDLLNIYYSVYAVLKKEQKYLIKELKPSKFFKSNILSKKDVKEFESFLLEKIFYWIRNNILEYQQVNEMYSYIVGDIERGFGIVCGGNEGGGGGNEGGGEGGNEDGGNGDNSKDISKEEDISKEEDISNKDKDSTKDKDNTKDTNNNTNNNTTDYLLDNILPLLNTLKEQNLLPCIVFNTDRSICNKLALKVLNSLEKMELSENINKIEIKKREKLLKEMKRNRDEKKKEEDWKEESIKEEENIEILEEKRNIKYCFLNPINKLSDYELEEQIKEVVRGKSIDKTYLEILSRGIGIHHNGMNKKYRELVEILFRTKHLNVVFSTDTLSLGINMPCRSVIFAGDSLYLDSLNYRQMAGRAGRRGFDTLGHVIFLGVSKRKIQNLMVSKVPDLKGSYSFINSSLLCFNKEYLISLFKYPLFDMVGVVGGDSNLLESGLESGLESGLESGLDKGKENGLGGKENGLGGKENGLGGKENGLENKNILDNTNNTIINNNNNMSVREVLIRRMYYNLLKYKFIEGKGLDNMINEVIKGVLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU77</accession>
    <name>A0A4Q9LU77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0859p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000859">
        <property type="protein sequence ID" value="TBU12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0859p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="661" mass="79292" checksum="07060A4630A14D81" modified="2019-07-31" version="1">MVRNIYYITFLIKYVYSSRYDIYRKPRAYIDGEEDYWYENTQGYQSLQEPKQISLSILFRSPTRETHTTSHLRNESFDDQYMYANRHEYRPQQLFFPLYGEHTYKTSRTHFRFEEPFEYEESSRRKQRNRYLPYYREEKKHRNPGSDFEEMRFRASRDNSFDYKLKDELNETYEPCKSRNLDERYCTERSDIYIENGFHNTEHKSKFCNPLYKNSNIKDEDYVESYNCTEFRDKNGLKIEKHDSCSTMELYVSKIKTSSKIIDTHGKNYAILENLVTEYIGFSDIQFFIEGDFSIDGYVLKSDNALFFELIDHIAANENGFWSQIDSDAMIKYLAEKLKESVERYDFCKPCSPLLSYAKNIVNLKYFIKSIIKEDINLVKNSCLWILLLKTAESLCNVQPNKIVCDKNIIGEVLSKEHKDFDMYNGDKNAFLVLKRLYMVFDKIARKIFRMTKIPENYIYMLDFIFINVIYRNKDIHISQGGYIYLSRVISDCIFQIKPKIIIFFISQLKNLGISKPKKFDSVYLINNLLITLYKNPHKVDSKIRLNFRLMYENMIDSYIELFENEFCGLVILRDKESLVKNELKHIDLIVQKHKNKKIFLERLDLKDLIDVAQDICVMLNHFIKVGLNNEFYSQKYIQKSTKYCNKRLKAIFKILEIYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW0</accession>
    <name>A0A4Q9LUW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1238p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001238">
        <property type="protein sequence ID" value="TBU11380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1238p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020764020" evidence="1">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="359" mass="42411" checksum="5D045B2183DFF1CC" modified="2019-07-31" version="1">MKKLIIFLEMIISTVFCTLESTVEDDIQHAQNQSGRCNFEVKRESQDMKVKIRDQHASNSGHGPKKAQYFGDQNGCDLFTSELSTSQFEPSPRKQKRRLTNEKNSPRLLENPQRNITIKMKLENEEAVKNDFLKQMLDSKILKIKSEDMNLPENRSYNLTVGYPIATETWYFDNIANIIDRYINRIFNDLNLSFANLKGKYNSKGNLQRNLKVLQLSIRRMNIVKNTNEEDYSSSFLKSSHDEVIENVKKELVNIKKVDNIYDLEDIMAYSDKIRIFGIKSKKTFTKLQLQEILTSLEIRNVKEELQKYRNIPSFYEFMLFKYRYADNIIDHIEEECFLMVHFLLEILFTKLENIFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW6</accession>
    <name>A0A4Q9LUW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA polymerase alpha-associated DNA helicase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0746p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000746">
        <property type="protein sequence ID" value="TBU12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0746p0020"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="220"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="333"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="439"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="643" mass="74623" checksum="4B3872EB066F5455" modified="2019-07-31" version="1">MDILQKYVDSLIFTLQKELEYLENEDSILNIYKAKIIDRKVFQFGNIISFKIIGAYNSNKTVITKKLSINKIFKEEENIKIFFHLENTYDGIKTKIICVEKDVFTCLTSTELKCREVYVRLEGSVYNTYRILKRLKKIEIENIYFDENILSDLRIKCKSEDTKIEQNNKEIVDFNEDLKLKELNFFENIMDKFQNLEIQNENENFGKILDELGDLINYTKLNKNQQRSLIFCTKNISYRIIGPPGTGKTKTVVEIIKILLTMDKSVLVCGPSNLSVDNILSCFVESEYHKKNKTSLFRLGSISKSLKTLNCYNLDKIASESVSFISEELNEAMKCKKIDKRKITEIMKEMKSRKNKFSKEKIKATNLVFSTLFSSHKIEGLKCFDWIIIDEACQALEAESFLNILLAKNFILVGDPYQLGPTVKSESKELKMTFFDKLKNVPTFFLNEQYRMNEILISFSNSYFYSNQIISPLKNNFKFFSHSPILFIDTSGYNSDEMKSNSSIKNIFEAEITLKVVKYLESIDNKHDVGIITPYSQQAIHIKEIMPQISFPIQISTVDAFQGQEKGIIILNLVRSNEIQDIGFLSDLKRINVALTRCIHGLVIIGDSSNFAKYQFYKKFFDHLYLHAYCIDPYILDALLETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY2</accession>
    <name>A0A4Q9LUY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0773p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000773">
        <property type="protein sequence ID" value="TBU12394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0773p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="403" mass="46904" checksum="B2F655812407E23B" modified="2019-07-31" version="1">MICGVLLSKTRYIYSLDVNFPNEIELEINNSNKLLKKRNPLGKGTYGHVYHYTERIEMAIKGQSLDGQCFEEELELCQKLSHPNIIHVLFSFKMNKSGYIAFEYFPRTLFSILNEEKICLRDLKIIFKQLLDALLYLEGEGVIHNDIKLDNVVVDSDLNAKLIDFGLACYVNRPRRIFSPQNPVSEERKNLFPYFSPEVLKGLDQGFKSDIYSWGFMLRNAASGILFINPGDFHTDVTDISDHALQVDLDARPSVDELIFHPFFDEIYEFLFCFNDYEDIKITSGDIYIEKIGSKIFLKGNEFEIALYCGCDYEKTDESVTRLLNMGIHSEKCTVCRTGLRVSKYARFKFELGGEIFPLHLFKMKELKRIKDYLLGIRNHFVLKRKPFYTLNCCCNYKLGFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV03</accession>
    <name>A0A4Q9LV03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0905p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000905">
        <property type="protein sequence ID" value="TBU12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV03"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0905p0010"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="614" mass="73355" checksum="6E73F1312B14F02B" modified="2019-07-31" version="1">MQFLFWILFLDFSKEESTIKKFDDMISEMKSNPIAFNISILFVSLLRSKTLCKTPESVLKTLLCDKAKRNIIEKHIFLLQKDMKYFTPSEIELLCFTAYFKPDSKFSWFLLFQTRIIYIVFCEFKDIMESYFTHLNDKCEFIEYINSYVSKYYFEEIQDDEDFFENIQENEKKIILNDFKEISMAYSKGVASNETMRSTEESTSNRNPDLSGGIQKYFGSLNSKLNKNKISENKVRKDIRQHTIFSKKPIYIDHEHVRKDMIAKAKNCHVTYGFHSDLTILFELIFEKYFHSSFDKEFYREHFNPEILKIYKVLSENPDEKIREIAFENFYKIIFTYFEKHIKNLLSHVRSESFFKYKDINAFFLDLSCHIRLENPTPCGLSFKSLNSNPNEIFCNSEYVFVFDIDDTLFPTDKISSAFEEIPGLLYTTPDRPLKDFLIKQEKLQTSKTEEEWEKIVEKFLQMNEFSKLSTILSHLKFKNKLKETLQRIQHRKICFTNAKNDWAYYVLKELDLLDCFDVVIHREYESLVTSVLKPDEKAYEFVEKFLRISTSNIYFFDDKSENIEAATKRGWKAFQVTESLVDVIKESLKSLEKSMKKNRRKNFFKRFLCTTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV78</accession>
    <name>A0A4Q9LV78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0399p0010</name>
        <name evidence="2" type="ORF">CWI38_1080p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000399">
        <property type="protein sequence ID" value="TBU02879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001080">
        <property type="protein sequence ID" value="TBU11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0399p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1080p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="352" mass="41848" checksum="6C0D4C79903DFCF1" modified="2019-07-31" version="1">MENKDIIVDRNMNCDIFKDTFNEKIINISSGSFDEPKGCYKTAISTRSMKNTELFRFLGELEPEDMSNSYVLILSLKIETKECNYIANIIEKIDKIVAIMNKDPKTNKNKLECGLKTEMLYLKTIYHDFSYINNLSVSEKIEYIAKNFTIENENLASTDTIYLLVNKKMDLSERCGLCHLLNQYFESFGKQNRYLYILMENITQKKPKKIVDFISEKKDDIHISFFIFNFKNLVYDLNTKSNVKKPTFSYNKKFHSILMCSYWEDKKPKTRFLYIGFEILLNNMTRPKKIYEIEIKENNTSHISKENPIIFKHRVNLVFFYDYLVECSYISYDEKNPAIRIKMLDFLSLKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL9</accession>
    <name>A0A4Q9LVL9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0806p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000806">
        <property type="protein sequence ID" value="TBU12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0806p0010"/>
    <dbReference type="OrthoDB" id="2188332at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="95"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="663" mass="76606" checksum="A81CC1D428DEC253" modified="2019-07-31" version="1" fragment="single">MSSLKNLISQSKTDPSVLSELQSQLKLLITSQSIDPIVELLTSESFDHQFYGLVVTEQKLKHLKLINSSVQPIHSLIEGYSSIICGENRDISSIPPFILNKFSDIYALLAIYDWPSNFPHFLPLLTNLFQAKHPFSYNIFEKFLFQVNTNTDISEKRRQELKKSISSIFPEVKPYLIDFNTNSLNIVNNILDIYINLLQIISPNSLPIPNIFSLASLNPNKSLFLIYELTTLVDMRSFLPEIQKLIFTLSYNSRLVDIFSILLNHNRYKEITNFQKISEYAISGFQGSSYDMESSLNFYNILFKRKDITDTPEFIKFYENISACILSNLIRVSNEIETDITLNINYNNIVSLFTLLSKKYQTHTYNILSCINTGLQINRKLSKILIKNFEHKESLCINDPYIMCYILYIRNNPDCIKYLEILDFNDDDSVKLAIKIVGEYVRRTDVNILLKNVLVGVREKCNKSDNEFCDELLINIYLFYNENIDVLMNGEWNKKKIGRFSLLVKNRYESVVNLTEEFFTFFVNSIRIRNTDCILIGYKICGLLILKNVKLPENILSVIYESVDNMNGKEIEAFCNEFANKLEISVQRVYINKVVQRVLVLSSQEVEDEMIGCQRSVVSFLEKSILEISKSTCLGKEVLEFYCSALTEMVLVGESSIIRKIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN6</accession>
    <name>A0A4Q9LVN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0568p0010</name>
        <name evidence="8" type="ORF">CWI38_1007p0020</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001007">
        <property type="protein sequence ID" value="TBU11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000568">
        <property type="protein sequence ID" value="TBU12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0568p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1007p0020"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="6">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20699" checksum="4A6F3BE55C299864" modified="2019-07-31" version="1">MFDTREFRKFKVNAYDKGKIVEFTLEKFDNDLFVFVFYPYDFTFVCPTEINEISDHYEEFLKRKCGVFFVSCDSVYSHKKWAETPREEKGIQGVKFPMVSDYNKKITTFFHLHREPDGHCARATVILDKNGKVRYYAVNDDKVGRSVPEILRIIDAIQFVDENGEVCKVNWKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVU1</accession>
    <name>A0A4Q9LVU1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0339p0010</name>
        <name evidence="5" type="ORF">CWI38_0608p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000339">
        <property type="protein sequence ID" value="TBU03188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000608">
        <property type="protein sequence ID" value="TBU12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVU1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0339p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0608p0010"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="3">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="3">
        <location>
            <begin position="247"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="401" mass="47052" checksum="0430006C00EF3E09" modified="2019-07-31" version="1">MVRHDRTGMVVSNFQLREDSEESILENEVGENELNTLTVRSLLNENYVDTENDVFYRNENENTNVGKKKKKEKRKRRKPDETKRASTAPRKIVNLPASQPYIRIVDGEERLCFKYNTKVSESALNAMPRADLEDNEFIVRFDLETVDIDKLNEKFKADNCVYPRANVTPESYTGNRWEYETECNRLAWQFVSLNPILLYGKKGLIQRAVDSYRNINKQSRSRRVVKQDKVGNTVIKRRHSDSAPLTVNLYWTVKGLTRKCKIRVDIEGVNYDKIDEEFKAKYSVFADEFDDRSFGLEKWESKNIDNELAVKIAYLNVDNTSFWNAVKANDKITMLRKAVEAYKNRREDYDDEDEECRTDISEVVSKTLDKTYENEEDEGFDENFYFLDSKSNKFAGEKNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY1</accession>
    <name>A0A4Q9LVY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1041p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001041">
        <property type="protein sequence ID" value="TBU11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1041p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="16709" checksum="F1F074C86EF588EC" modified="2019-07-31" version="1">MKEIEKCELLRNSMYDFKSILVLKSGKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNTVETISFNRRRGLESKPNAKESWEPHFVQNKEQPTTNTNEELEKEIEVVEMVERIILEKRKIFNPEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW81</accession>
    <name>A0A4Q9LW81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0566p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000566">
        <property type="protein sequence ID" value="TBU12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0566p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="717" mass="84353" checksum="C58A18B77DBA1A2B" modified="2019-07-31" version="1">MNKNSICFSRFVKKKYFCYVHNECIKCSQFLIENENDFPLNFKNKDEGESDHCIFLNTKVLKFNEFLYFFKIIKEISELKENFKMCDFLLILRKLEVFKFKKDKNFNLIVRNLLLSIVFNSKYIYANNNLKGKTIVSTSMLKLLFKEFGRIYFLDASLFFENASGIKIKEILNKNFDINFIFDPKFVCINSTFITVINELVESNLEFLISFRIIFANIRNTRAILYGNRSSIRNISSRICYILFSNIEKFCFHSWEDMNFFNSMCDKLIYKKVTILIFFRCRFSVFSESPFNAFKSLTRIYFINSYITNPISLGKLYTYLELIFSFYNEITNETNAAKILKLATDIQPQFDNIDAVRFFDFNKSLMISQEFKSSEYLVCLVDEIYYVGSYFGIYMSVSTFPQNVKSISVIFKEVSLRGFQLQNPSIFNTTRELSILDSEFSNEFLLDILLLPHLEEFVICNCKALFEKKLTYEKRSSINNFSISGSTFTNSEEMINFVNCMPNLKSLTLRNNKNLYMFQSISTNNMIWSSSLEILMLLDERKFQGVLPNLSCLKIIKNFKFDYGLYDEGSLLQLMGNQGLINVCNLSVYNFKIGSRDKDAIKNISEIKNLSFFNCTFINITFSQLFDPTKKYTIEKLILERILLTVVDILFLSNLACLKYLEIETSGFLFQSKDFSKVVLLNLSQLRIRLKVPMQFLRELNYFKEVMQSSNLEIYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD3</accession>
    <name>A0A4Q9LWD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0942p0020</name>
        <name evidence="8" type="ORF">CWI38_1013p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001013">
        <property type="protein sequence ID" value="TBU11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000942">
        <property type="protein sequence ID" value="TBU12005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0942p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1013p0040"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="46568" checksum="C9B920BAE7AC0824" modified="2019-07-31" version="1">MRIIIEREGMSVFSAVFVMLTTMMGSGVIMLPCAFRGLGYILGPVILIFLGFLSFFTLYSIGFATSKSETDILTYFNVCNKFSPILSYVADISFILQGTGCCFVYLTALKNWISLLFKSKNLALFLEIILMSIILILSIQKNLTRLRYVSIISVISTVYLAILMIYYYFKLKDYIENVIIIPFNTDFSLSLPIIIFSLGCHQNLVKIYSELNSRNLKTITIVSLISICLGSIIYTIIGLVGYILIGQNSKYNILEYFMKNQEILKTLISTKSWDKNLVLIKMALIAFIIVTVCSFPIQIQPARDAFLNIYYLLSKKNVIEMGRKKNEKDKLILSLILSTTLIFISWLIDLDLEKLIKFIGATVMNFVVYLFPSILYLFSVTRFKSGSIVALLISLFSFISMSYLIFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX84</accession>
    <name>A0A4Q9LX84_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0473p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000473">
        <property type="protein sequence ID" value="TBU13304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0473p0030"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="26145" checksum="146ADF4F8F0E069C" modified="2019-07-31" version="1">MVSINDRERIIEKTLEGPSIFAIASMYLINYQTVNSIVRRYLNTGLVFVDKRSGDRRSKLTLEIKENLQAYVDLECTKTLYELAEWVKCTFNVDVSTSTIDRALREFHYTLKRRKSVPERRNSLSTLELGTNYATSFRELEVDNDDKNFVFLDEVGFTVVTRPSRGRNMRGKSAYLSVTAARSRNISVVAAMNKYGMIYHKIHERAVKGEDFKLSIKEIDESCQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD3</accession>
    <name>A0A4Q9LXD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0565p0030</name>
        <name evidence="1" type="ORF">CWI38_0881p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000881">
        <property type="protein sequence ID" value="TBU12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000565">
        <property type="protein sequence ID" value="TBU12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0565p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0881p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24210" checksum="F903A7634B703BFC" modified="2019-07-31" version="1">MNFTCCEDTATVLEAVAVYKYLRIVEDTRGISTPSTFEELDYVVRPVLVENKIHHFPECKKLLNLSLTKLGRGLHGNDKKTHPALLEAFLQIKYWIEEEVTKNKSEEAQHAKLYNEIGKQKLHDIEIQINRSDIFLLNKIIKKITHNEVGNILQDSLQIEYDLLNNDLDFIYEFGKSNLVNKMAAEPRKCAAMRVMPETENKTGIIPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD7</accession>
    <name>A0A4Q9LXD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0427p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000427">
        <property type="protein sequence ID" value="TBU13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0427p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8768" checksum="290D0BFD3A1AB8D8" modified="2019-07-31" version="1">MNKAKIERYIVQNNQESSKETTESRFTNVYMKNFPNKYGEITFFYMSLDEYKLPKEFAFANFATNQNHFIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ0</accession>
    <name>A0A4Q9LXQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0391p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000391">
        <property type="protein sequence ID" value="TBU13568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0391p0020"/>
    <dbReference type="OrthoDB" id="2194678at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12250" checksum="47D59378E37B4256" modified="2019-07-31" version="1">MRLTLLHARKNSSLTIELKTNYATILREFEVDNEDKKFVFSNEDRFAAVTRSTRGLNMKDQSAYLSGSIYYDIHERALNKENSNCSLRISMKVRVFDDDEEIASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX8</accession>
    <name>A0A4Q9LXX8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0638p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000638">
        <property type="protein sequence ID" value="TBU12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0638p0010"/>
    <dbReference type="OrthoDB" id="1739492at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28576" checksum="CCDEDE4B62E0E137" modified="2019-07-31" version="1" fragment="single">MENVEENLLNSEKRDSKYKQITKEQRQGILEKLLQQMKENKLKHGKICADVSSKKKKRCGRKPKEYSKNLAQIRNTPLNRRGTLRSLSVAIVIPKSTLFDIFKISSTVKPTLTDKNKMDRLKFCLSKVNLANNGDLLFDDLYDYVHIDKKWFYLTKVKRSYYLMLNEENPERNCKSKRFITKIMFMAAVARPRYDAHRKLYFDGKIGIWPFVYQAPAQRNSKNRAKGTMITKNVESVTAVHCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY42</accession>
    <name>A0A4Q9LY42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0348p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000348">
        <property type="protein sequence ID" value="TBU13738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0348p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020711506" evidence="2">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="9071" checksum="E70FF135C3036F3C" modified="2019-07-31" version="1">MQKIYHILLIILLCVINIVYAEPSKSSSSKKESSSTKEGNSTGGANGTSGGNGTGGTSASGNSSAIMKEGMSGSAVTAHFRRAELTLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY61</accession>
    <name>A0A4Q9LY61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0681p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000681">
        <property type="protein sequence ID" value="TBU12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY61"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0681p0030"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="4">
        <location>
            <begin position="155"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="519" mass="60279" checksum="C391AE4020B325B0" modified="2019-07-31" version="1">MRGLKDFKMENICENSPKYDLPDSLNISLENKKDFKMENNCENSPKYDLPDSLNISLENKKDFKMENNCENFPTFDVNNSLNISLENKCENLCSSKLFYSLDSSIETSINKQTENDKEQSHLSESQLYDYYMTRLESKTINSNNYLQSKLPILSLAPMLKVTTPNFRKLLSIISPTAILFTEMIVDNTIINNDNDYILNKIGLPTTNTVVQLGGSDPQKIILAVQKLKLLGFKNFNLNCGCPSTKVKKGCFGAILMKNVQTIINIINTTHQYTNTVLSIKCRIGVDEHDTYSWFKNFISQIFCHTPCRIFYVHARKCWLNGISPKDNRNIPQLKYEYLYQLKSEFPDIFIHLNGNIKVIQDIHKIYNLDGLMIGRAAVKNVFIFKQIEEYITQYNKEKYNVKENKENYHTRKNTTDIKNITDYTNITNYSSITDSNIDPKNTINCIDTINSNTDFIKEVFIKYIKSFNCNDRITNNLIQPIINLRYGMNRNKEYKNVLNNLVLKKSKISEILDIIDEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC7</accession>
    <name>A0A4Q9LYC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0321p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000321">
        <property type="protein sequence ID" value="TBU14725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0321p0030"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU14725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="39943" checksum="146CC3E3B4E3B014" modified="2019-07-31" version="1">MLTKAKLFIPDTDLTRIKIHPSLNIICLIGKRSVIVASSCNGSLELIQRHLDEDKLENYMCCEFAELKKGCIIVVGGSRGVLKFLNLNTCTFEGYLCGHGGAITDIKSHFKYKNTIFSASEDNSIRMWNGETKKLMAIFGGAAGHKDFVLSMDISLCGQYLLSSGTDCQVKMWKIPDIENRRDLIETCYFPIYSTSNIHRSYITCVKFYGKLIVSKSVNNRISIVRPYLSVEIYDHPKCSYSSFINELVYFESKFLTKKFEIFADTMIIGSESEKDVIYLTNLNRLQDGISSICKIKTDCNKKVRDIAIKNEEVYILFEESIILFMNIKNKISTKPEQTIFDNNLPTKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL1</accession>
    <name>A0A4Q9LYL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dopey domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0448p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000448">
        <property type="protein sequence ID" value="TBU13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0448p0020"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="6">
        <location>
            <begin position="2010"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1555"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2363" mass="273983" checksum="1461C5F282AD9D76" modified="2019-07-31" version="1">MQPEKNTDTRYNTEIKKKLDAFKTAKQWSDFISLLSSLDTTLKKHNTTYIPHKTQLFKRLSQCLNPALPSGVHNKVLQTYHIIFQKLDTQNFIKNFNLYTLGLFSFSIHTRLILKSQYVTLIHTHIIPLSPYLHPFISNILLGILPNLDEENTDHYSQALKCLKDLLTLIPLPLFNTSLFYLLQTCTHLRQPITNYLIKYSIQYKVYITLQTIKAFSYSLKDKEIFVLRSILDILIMKYNLKKILEYSGEGSGGVGGDVGDVGDVGSDKNKDSSGDSDKDIDNKDNIDNDNIDNRDNIDIRDNIDIRDNIDNKNNIDIRDNIDINNNIDIRDNIDINNNIDNTPIIDKDIKDIINTDVKDKERNMILDISFKENNNGGNDSGNNNDNDNRGNVLGNNVIGNNDIGNDTLNNPLNNPLNKDTLNINTLNTITNPITNNPLNNTLNTNNNTPLNTNNTSNNITLHYIVDLSVNILKLFLKRDISLTKRVYSFYEISDSINKTSLNIICLSLYELLKRKDFISFFKIMICLSDKKDVCDSVLLLITPYYLYRIYEVYGYIGDMGGIGDMGYRIGYRLENNPNTNNTHYTNNTTNPYTNNPYNTPYTNNTNNNLININVDVLKYVNLFHDTVEVSFIWKLVITSFIKRIKGICDSDSEEGGSSDEEGDSSDSGSSYKGDNKGGSDSDSGIGDRGSSYKGDNKYKDIRHINNSTNNNSTNTNTYTNSTNPYTNPYTNPITNPYPYTTPTNNTTPYTNTPSTLITPLPLNHFIYVLSFFINNFNFCDKEVLEIHILFLFYLCLKYKKYFKKEELTVFLLLCIERMEWCCDSGGSGDSVGGDIGGIGSISNIGGIGCYSASSISDMYNTISDNINDNSINDKKNNKNTKVINNKDINNKDINNINDKNNKDINNNINQHNNNTHNQHNNNTHKNIDSLNSLHISIFNYYEGVNDSIINNLDIVYVGCYLLILRFFKDKKNFHFYNLILVKYLERMGYRGKGDRGEGDSSSSRGKGYNNISINNNPSININNPSINNTTPHTKHINNTPNTNPYITSINNTTPYTKHINNTPNINNTTPLPLSFLHLYFNIILQGSVNELENSLKIFKNYKLEGFYSLELFKKLWNNFNFRMCYLLYEFNILYCCIFERYVIIRLSGISNNIEYYSRDLDDSMCDSDIMCDGDSICDSDKNLDNSNKNYKSSSNKSKSKSNSSKSNSNKSNSSKSNNNQYNNKYTNQYTNQHTSNKYTDVYKTSNLLLFIINVLRSEELYFMDAFVYLNRILRESMWYKGNDRDIRYKGDISNTIRDNSNTIRDINYKGDIRDTIRDINYKGDNSNTRDTYNNSNTYNNSDTIRDINYKGDISNTIRDTYNNSNNIRDTYNNTPSYNTPSYNTLSYNTPPNISNTSDVNIFLTCLKRIKHFNSIYKFILNKLKNACIESKEGYYYDMIEYDIVYGVFDCLINMFEYCNEFIIFLRSSVYVQGDGFMVFLNNGVVNVRKVLFSSFLYFVINDVKCDLGCGDGGCGCECGDGGCYSKDSNYKDSNYKDNTKDSNYKDSNTKDNDSNNTDNTTYNTNNTNNYNYTNNNTNYNNYNNYNNHPNYPNTNTNYPNNHLSEIRRVRLMALFLISKMVDLNMLESQEIISYDLNPFISFIIKNINDVLIVWECLPLLKILTGNEQWVNIYFKKVFEFLVVYFSKKYSFFIFEILNIELRNKVVCEVVSSNMLWDMDVCVVQGYFSYVFGNKEYFGDVLEKLVCGCFRYVEGKVGGGIRNYDILIGGSIGYVGNREIVEGDREIVEGDREIVEGDRELREGDRELREGDRELRGNNRDVKEVRNNKEVKDLRRDKNRELRGNNREIKELKEVKDIRKDVNQTPQNNINNIRNDVLYDEYSTSYMFKGLNIKETSNFICMDSLIEEFKNINFKKCVDLNVEPYILLLDFIFLKENILFAKCLLNFKCESIILELNSSKLNLYMIYLEKFNKNIEIFPFLCKIEESFSEERILVILEQSINILNIMFLGRIVIRILENSFTVFLRTLDLPNKKKENKDILLLIKVIRNILENINIERYSLLFNNVVYGLLRQRNYLYSESLGILGLLKNWKKDFFDFFCDQKFFNDSYENILIKKNLICSFFSGEYEKIDELYNRMEQGFFVSKETDSLNKCSIIRRIAFLVFCLDKKIIYSKFPPIIEIISEFITNTSSNIKKEIIFLIKIILIKIDTEKLSHLWPLIFCEIFNEKEDLEVECETVRLIDIIFTFNLEETVEMLCDYVGGVVVNDSELNSSFVHYLSLKSGDEQSRCEIKFEDKIVPLCKFIDVKSKSDLKWFYENCNQYFTEARIFGREVDYEWIEDNVLYEFIEKIESYNEVECYKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM5</accession>
    <name>A0A4Q9LYM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0310p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000310">
        <property type="protein sequence ID" value="TBU15612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0310p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18946" checksum="FCCB2ADC87291819" modified="2019-07-31" version="1">MVINTTIFETVFSDKKFDDNLNLKSIYLKNTKKSFYILLKGLFDECNFDIEIIKNKFYILEFKTQYCDVIETFENNSLQLYLKDNFLVIFGQMLHFRHKLLIWFFDLYDVTFIWIYIEEIDEESYMQKPGNPYVNQEYLSTLRSLNKNEAFHSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS4</accession>
    <name>A0A4Q9LYS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0272p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000272">
        <property type="protein sequence ID" value="TBU17657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0272p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020674964" evidence="1">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="51686" checksum="153AB22B4BC440D7" modified="2019-07-31" version="1">MYLLWNGANKLIIILGLFINLSKESFDLTEHRDYFARKCSDLYTKETKNLQQLPNTIDCGIFMFYARLYTYAAVSIANYINNSISKVFDVVFYRPDPSNYEGSKKISYKVFRLNKLNDKFLYVSRYYQLEESTHYATGLGTFSYILLKNDKTLTYFMAIFFHMYKIFGYLARTRDNIRSSYIKIQDITNSKRTKIPKKFEMFQVNTFYSLQHRIFYVKLFAEIYISEKLNISKDKMVQNFNSLFGASKCVFSGSYSYYYIENKRVETKNSGKTNISWKSNVRRNTILIRHELTGFKPLMDLYLLKNVKHTLKESLIEYEYYNEDDITTGKPKKFRVVFRYNSAGFEFNSNCFVDCIVKTYRPDTSIYIIALRNYFFNIVECEREAVDSNNFRISRTRKYNILGKNSLEETQCSTQRVSSIKDFMEELLFNRVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ45</accession>
    <name>A0A4Q9LZ45_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0556p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000556">
        <property type="protein sequence ID" value="TBU13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0556p0030"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="15367" checksum="84ACFA73484841FE" modified="2019-07-31" version="1">MYIDLHNLVITDNDKVEEEDINSKVSKLLRTAFNLIKRIPPTGSGKDFLWEHSTKRIIHPRMYPKEEKKRTRWELFAEKKGINRKKSRNKKYEDDLQDYVPKYGKNSKKNLEKSVGIYEIKSTLKKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ66</accession>
    <name>A0A4Q9LZ66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0532p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000532">
        <property type="protein sequence ID" value="TBU13100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0532p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="28522" checksum="343AE74077DB8D73" modified="2019-07-31" version="1">MCQHYNKSGKTDDNLATRCERMLGHDYTRRKNDVVKCLHILLINRYKFKSSKRIRSHSVQEILVNEYAEIRVDTRIKTDITLLEVGIISKDSLQKVETKKISKYDLLANEFSLIYKCSVEIIPYVMTWDSIVTKYHKSHLKRLEIPMNVEEAYIQSIVLKKTVETISFDRQRGLESGLNAEESWERASMGVIMRSEIHEEPLPPLNEEKREEDGGTTLEESTNNINKESDLEEETAVIKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG9</accession>
    <name>A0A4Q9LZG9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0216p0040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000216">
        <property type="protein sequence ID" value="TBU19280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0216p0040"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="247"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="356"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="487"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU19280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="660" mass="75576" checksum="790FDD3271A1C3B1" modified="2019-07-31" version="1">MKPEIGTVEAIFNNQEDHPLFTKPILQVINFEKAKRSGDEKSRYIISLSDGQYSIKGMISSTCATNFENDSIKNYSLVQINNFKIKFKGTIPFMYILEMERVGMSAVRLGNPISIQSKRLSNEPSSSNFDDNIRHGNIIQNKKISNEPSMSPNFDENVKESPSTYQTNSSNQNNSSNPTNSPNPTSSYLNNNSSNQTNNSKNNSPNQTSSYQTNTNSLKNNKISNPKDDSSVQATPIAALNPYSARWTIKGIVTVKSEIKHFTSQRGEGKLFSFELRDTSGQIKIVCFSDSVDLFYPLIVQNKTFEISKGTIKMANSQYTSSDYEIHLDKNSSVQLSLDIPQPPLTYNFIPISEISEPNKIFDVIGIIKESYPPSKITTKFNKEMKKKDIFIIDKTSTIRVTLWNRFVEENLEIGNIIALKGVKSSEFNGINLSTISTSLIFINPDLEESFSLKGWYDLYGKEVKIKREEERKLICEVKDYELEYSLICGTIMFIKEDSLWYNSCIGDQCNKKVVLEDNGGYRCEKCNKIYDDCNVRYMISVHVGDFTGQLWLTLFDEAATRIFGISAKDLKNLGDESPTHLQNIVKGLYYKEFYYKIKRKEEIYNNESRVRYNVLNTENLECGKEIRKMLSIIERSMDIKGKYIRIRVEYFNKNILFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL9</accession>
    <name>A0A4Q9LZL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Endoplasmic oxidoreductin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0204p0030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000204">
        <property type="protein sequence ID" value="TBU19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0204p0030"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020337634" evidence="16">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="41131" checksum="81AE7DCE9A789824" modified="2019-07-31" version="1">MKIFFLFIVVFTNTKVYSSIKQKIISFNSEIHGDLKILCESDFFSKIRINLNGKCNYNFGKKCGLFSCNVPEQSKINQKINNNDLYCKNDGTEGVCIDLIKIKEIFTGYKKESGEVWKKIYELACKNKDIMKIISGIHYSVCIHMCKFYRINRKGEYIANTWMFHKKKNLNYEINLYFAFLFISSFFKANNFNVEILKSSLKNNELKSFFRVSKLVDLHVWTNTNINLSSISEILNLLNCLGCERCKLWSKIQFGGVETAIKLSNEIEISENDLIYFVNLLYKLSSSIKISHEFEKIKTEKPKNYKLLANDLGLIYKCSVEIIPYVITWDGILTKYIRLYKRLQIPVYNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX7</accession>
    <name>A0A4Q9LZX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative subunit of trafficking protein particle complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0181p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000181">
        <property type="protein sequence ID" value="TBU19879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0181p0020"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20270" checksum="52650C2BBA66618C" modified="2019-07-31" version="1">MDGKSSEKISADFFTHLYGATVKHLLNENEDSNDILINVGEKIGNRLIDDYFYRINCKKTMNIKEVANNICDTFFPLYLGYSPQLIENNGIFSIKFESFYLLKFIDTSNEEIFSKKNVKFLNMFVGILKSVYSYLSSNKIVFTDNSDKEFIISVSEVQKKENESFVILGTKVNVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M042</accession>
    <name>A0A4Q9M042_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0446p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000446">
        <property type="protein sequence ID" value="TBU13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M042"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M042"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0446p0050"/>
    <dbReference type="OrthoDB" id="2195620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="560" mass="65313" checksum="19FBC6532362BD9B" modified="2019-07-31" version="1" fragment="single">KKDENNLNIEEDESNENLNTEEDFKSKENLNIKKDENNLNIEEDESNENLNTEEDFKSKENLNIKKDENNLNIEEDESKENLNTEKDFKSNENLNTEEDKIVDSLNTNNDDNIENNLNTEEDKIVDSLNTNNNDNIDSTNIEKYEESKNVFNEEKSSSLTTRHINSSVMNLFEENKSRIFLEKNLESLRDKQLINENIEIDEETKENDLFSDTKSLLSLQDEKINGNENKSVYETKTEIYTSDESTSSGGQEFVEREVFATKKIDEKNFDLNSEKVFSEKKVDFTEENINSCVLNEDTDNFSELKGIIDQKVDEQVINTESIYFECTEPFTEEIKIPETVVSSEKRRSSYIKESDLEKDFGNMSIIMSDSTDLQSTKIKYENEDIFLKRMLKRHFLNFKKNGFIFPRYGFKEISEVISRFNSLNNIAHMLDSKLEIEKVKDGYLASSRHGTAFFTNLIPKRVGTVVFCCRTLVLNSKFQKERFFAVFEDKKGPICCLALDDKFHMSSANHYVLQMWRYSHEITDLDLESIGINLENRIGDISFETFGDFEWDSLNIEESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E5</accession>
    <name>A0A4Q9M0E5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0143p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000143">
        <property type="protein sequence ID" value="TBU20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0143p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="39041" checksum="91F99932E6ABFD1C" modified="2019-07-31" version="1">MLFGIIITFFMIKKFNAQKSRSMAIYVFPVHIFVLIKSVFGAQRCQSTGTYILPVHVHFDELSLCYLTYYFKSKTNFILEEEMRKNDDIITEKLMAEAKIEDADANIAVEEDLHSHVATPSEAHVSEIVVEKTNLPFDYITPNYNQCGYRHMSNEDLVYAKEFIGTIFNLINNDIMKYGVQFKMIFDKVLPMNDIGNVALCWESSPVRSKTKMMALHQNYFGIKGEANRIIIFFCPNTKDDTYSNIQVGKCGNYMGFIYDTPEYLAPRIYDNMANMVSLGSYKNGVDSPIFHTRICEYTNKCALKTFEPIGYFEKGNHPINNQVDRNYHPITKDNKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F7</accession>
    <name>A0A4Q9M0F7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0232p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000232">
        <property type="protein sequence ID" value="TBU18730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0232p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="25994" checksum="351C379CDF3239FF" modified="2019-07-31" version="1">MIHLWLGCKERLYFSITELERGLHSVEQAATLNVENSNKTHLALIKCFLKVKYRLEEELYNGRRNELVSDSYAILQSSAIPKIEMYSEKICQNEYAEIRKNTRTKIDAKIVKNFLYIVIFIKRKNKITLIEVGITSQGSLRIPGLIYKCNVEKILYVMTWNGIVSEYHNIYPKRLNSEESWESESKGSDLEEVATLVKKVEEMIKIVNTLYLSKFIELNKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K3</accession>
    <name>A0A4Q9M0K3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0383p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000383">
        <property type="protein sequence ID" value="TBU13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0383p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="39550" checksum="4D9B640AD6720B51" modified="2019-07-31" version="1">MYFQGFVYTENLSSNKLRDKSKSILDLPKDEQRGIYCSRNSASSSSDISTHGKTVHDALEPLYVNFFLEEMPILLQNQGISELENILKSEALVDDKYFSVFSTLNDIKEKYIEFSQGKIQECERIFSKILQDINILVKKSNILSKVPSLVYLIKYVNQFILTDIIYTSDKSHIRVLFALKLVKGIITKSEYEIERNLNSFTSTNPNNIDFDIEMKQIYENIFFKEDNSYLLDIMFRFDESDINEIYTLLQEDKNNGTGTSNFHKHLKSRSRKLSDHFISKIICYYFQSFDAKYGERFYALAQGYHTNKPIENDSFHGIVNDTYEFVHAFVSFRKIIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U3</accession>
    <name>A0A4Q9M0U3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0105p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000105">
        <property type="protein sequence ID" value="TBU20249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0105p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="23243" checksum="6D49C08F61CC4078" modified="2019-07-31" version="1">MKKISSTVKPTLTDKNKMDRLKFCLSKVNLANNGDLLFDDLYDYVHNDEKDNDKKNVESVTAKTIYVQQNNAKPHFSDNDADIVALGSADDWNIKFKVQLANSPNLNVLGLGFFNSIQSLQHQASPHTIDELINCFQDAFHQLEANTLDNVFTTLQACMESIMLADGGNCYKIPLLSNGKLRREGRLLEKYVCSKEAYLKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M118</accession>
    <name>A0A4Q9M118_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0083p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M118"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="270" mass="32561" checksum="C223042156531C9F" modified="2019-07-31" version="1">MKQKKIFKISDIDNFGLKFEILDKLNVQNSNQEIFLCNHIKALEFELFYSFLIFFYISHEKITIDGFYTILYLLKYFKVQCDNKLRDVLKNIFVSLLRSNDITNLDVTKILFDLSKKEIFSHEFFKKIAEEFFNLFIPAIDYVSSLYLKEQDFLLQEKYYPLYTDNRRYIMRLNRNFFLLVAQIINANIKPIDEIIFYKIPIQDQLIISLNINSNFASMKRIIFLESMKETNMKFSYNLLAVNEIIFYDQFYIYQEDKIVESLILKELTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M198</accession>
    <name>A0A4Q9M198_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0065p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M198"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M198"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0020"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="283"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="652" mass="78720" checksum="7123073E99C08058" modified="2019-07-31" version="1">MKKILDDKIIVKTSCKYKKNMTDITIYVDKIIISGVNFYKVIKLYLISDIRNIESTDIEILTFTDEKYTFSDFKRINLIYYFLVRAIKYDYEIRFGINILKNESDNCIMEFNIFNLKEYLIEKYRLIIKNEIITSFQVKYEDYSGRIYLFNNYLIFDCKKGIVIRLFQIKEVEIEKCITDDMLDYIVLKINLVFGGIHEFIMKENKHFLDSLFNLISENKKYTNIFTDEVNKLYQHKKNNDFEGFGTKYTFNKDYEPKNYNKRIFSNIIDIYNINNYELPEIEVPCELKGFFWILNMALDYKVIQNEFYYDLKNKIGDLKISKQINDDIHRTFSDNSCYRNIENVENLRQILETYNVYKPDVGYFQCMNVYVGTFRIFVNEEMTFWLLNYFIENVFNECYEKEMEGIYIYEIIINLFIEKYFPGLYKNLEKRNISISSVLSLWCISMFVQHLHFLQFLRIIDEIATKGRLFIFKFCLSLIKNIYVKLNRSKDINDAIFYFKEYFEKIKEDFNRGNNISFENILSSSNKEYNFEVEEFILFKSKAFIKYRDNCIREVFSDLSKKEKNMFLSKKEISLIYSKLNNLKNLNSENISHIFKLNKEIVEKYFSNENLTFIQFLYKINLLMNEITLTIDLHLKEEISCLLSQILNEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M3</accession>
    <name>A0A4Q9M1M3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0183p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000183">
        <property type="protein sequence ID" value="TBU19868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0183p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24459" checksum="A946588781EB6B57" modified="2019-07-31" version="1">MLEEPTIKDNAESDIEEETMVVKELYKVENNEIVVNNSIRWLKKGRVRPIDESVFCYIHDGHVTWSAGGVNQHSHTSRKIDYTRQHNEVSIPKIFIRVFKAKSDIRIRTDAKIWNNTPNTLRMVGKNMLRGYDLSANKLGLIYKFYVEIVPCVMNWDRIVTKSHKTYFKRLKMPMSIEVYIQLIVIKKIVEEIFFDRPRVSESEPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z6</accession>
    <name>A0A4Q9M1Z6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0031p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="15593" checksum="53A79C062A868805" modified="2019-07-31" version="1">MFLKTLELKRTQNNREFLQYILVKSLKNPMFDFSLIESLLNHDEYDSSFYITKLEYLFSKFGKFVYIHEAQSIFLSFKNTALLYEKNSVISYQNYVFRTKKLFKNNIFSISEYKILNVEKILKEKKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M228</accession>
    <name>A0A4Q9M228_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0244p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000244">
        <property type="protein sequence ID" value="TBU18375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M228"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0244p0040"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="349" mass="40930" checksum="366736183B2770C2" modified="2019-07-31" version="1">MNTLQSLIQNKDHKAISLLPSPTYDVYKGVACIHMEKYNEALNFVNKNSYEYAYCLYKLKNYKKSIRILKKLENTPKVMILLSQCLYYLGYYNGAYEILSGLSSDDEIVVNISAIKSMAIYSSRGSINERLGLSSKDIFNSKFIDFSRYKFTDTECHKEYLFNQTFEYMNDKEEYLKELQSVSENNLLVKNQIKNVNGEFSELDSVKLTRLQREVLELNMKKTKFISKPTHFLCNAFEIEDLNEFKSLELNANSFYCYLYLASKNLYSFDLLPIFENKREKLKLLYNYIHYKGGNSKSTDSVNSTGKKLSEKDVKTALKLLKINEKFDKKPNKLFERRLKLFIKKLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2A2</accession>
    <name>A0A4Q9M2A2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0018p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2A2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0010"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="408"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="898" mass="103990" checksum="1F304F2EB21B878B" modified="2019-07-31" version="1" fragment="single">MCDVDVAMLSERLPPPPTFYDTTQQAVVERLVQSAWLTPYPPNGMTNLNRDAILERNRLMLLHSILDSVTVVEQMPRNGWSATLKYYNEKFSCTLDIDAFRKLPQNKAEREIRQEENGERRRITTCLTEPCTLTDTTEYINLRDKFLSKIKEISEKEIGKVVFRTRKLPSELVDSKVLDLINRIIGEYADSCVPMTIKAVERIIQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSKTKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRDRFYRGLSERVRDEIVSFWSTLWNKNDDSVMYDDYLIQFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQADWFYCRLTYLIPKGIPRRGFYYRPITCMLDLYKLTTKCVTKVVQLEVERQGLLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIEKLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKHTKVRVQTDAESHSTNHLLFINDLKLLAKDSSTLKGIGLEINKEKSATNDTCCEDTAILLEGVSVYKYLGIIEDSRGIQTLERLCHTRLNAKKIFLLRLEPADFSKLDDAVRAVLVKNKIHLRSGCKERLYLPRTELGRGLHSAELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H7</accession>
    <name>A0A4Q9M2H7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0004p0050</name>
        <name evidence="2" type="ORF">CWI38_0006p0080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2H7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0080"/>
    <dbReference type="OrthoDB" id="2245799at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="185"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="587" mass="68372" checksum="FFF6608DA76E21F1" modified="2019-07-31" version="1">MLFFGQPGFNNPLSRSIIVENEASMIVPVIDIDPDMVLVEEKAAGTQWILEIASDVHEEFTEIVTNIIADDHESDGMIRSDVAKNFKKRRYWPLTFINTILIIAEHFTLLGDDICFKRRDHLIRAFFGFITAFIKQIMQTEHAVAHIGVNKMMALIVQKYYGIPKAYIREYVKDCEACSRFNSLKTIQPIYINHFTKKYDLFMMDCVDLRRYSDQNDQYSWILNLINKTSELVRDSLKFLFDNFGVPMAIQSDNGREFKNTLLKALLTDLNIKFIHGRPRKLKAQKFTEIVTNIIADDLEIDNNISSEICLMRSSFDKKKDFDMNTKTKRAPFDSFYDNSVFTVTAILMSNMIEVKNNDGDTRTVFRGAFRGLRGKNDIEYEEEEFNEKISSTFKINSYLENTDQNIEILFDEDQVAVENKISTCMKNEANVHLFRSKLYLRDNNQMTKKGKIIGFCEEKLRKVLTRSRSESHIFNDKIQILAYADDVDFIARSEASLQGAYIALESAAKKIPVLMFESEFWVVKKTDEQRLAVEETNSWEFYSKLRDMPVQHRIPSKVLNYIPVEKRNDWWNVILERDAADLSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P4</accession>
    <name>A0A4Q9M2P4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0097p0010</name>
        <name evidence="7" type="ORF">CWI38_0127p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2P4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0010"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="6">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="23487" checksum="660ED550DAC5C54B" modified="2019-07-31" version="1" fragment="single">MENQSTIARFIQSGIKYAEINEFLSKELREEGFSSMSMNSYNLPIQITIRALKTHEIAGDKKTRIKALQSVIAQRLNVQETDVVIALESVQNKGLCPFIQADSIRQKIQANIPFKRAVNGAIRTIKEAGAQGVMVVVSGKLKGQRAKSVKFSDGVLLHSGQPCEDYVRKGFTSILLKTGVIGIKVYIMLPYDKDNINGPNKEMVDKIRVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P5</accession>
    <name>A0A4Q9M2P5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0165p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000165">
        <property type="protein sequence ID" value="TBU19952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2P5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0165p0040"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16363" checksum="674683B3B319604A" modified="2019-07-31" version="1" fragment="single">MDNCNIIKENDFVYFENKHDLKKIRKVSPKENIFVRKYKLNINTSKFIGLKYNEWYNINGEEFIEIETKGSMEIETKGSMEIETKGSMEIDTKGSMEIDTKGSMEIETKGSMEIDTTKSMETETKESIEIDTKGSMEIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2S1</accession>
    <name>A0A4Q9M2S1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0004p0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU21005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2S1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020237850" evidence="1">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="432" mass="52022" checksum="B2EC2403A2DFE355" modified="2019-07-31" version="1">MILSRLMNLYILLILWRTIFSTIKPIEKTNYNVDKVYEILCKEVYRQYRKRVLEMDYVFEYDFLILEMIPMFVDECDLEVFSYLYQKQLESTFLHFIYLIKDQDSFFELKTYFLFKIIENDVHCNTKDKYCIKTDSILYFCKKQLNFGILENFKKNRYVFTFLNRLLNYLNCIIKLMCKKHNIIIFKSISESQWCESFTLKNFLLSLLIQNETTIDCDYSILITKNKKNKISVPFNIANILKNTFTSMFYLDKSFSSLEKFENGALPPIFIHSMNHTLKIYDRNIVSFNILTRLNLFEINVSQFNSKAEKESKTKNTKYFCTYKFLNLDISIYLIKPKIRKNKNKDTKSDKNILKIVVKSLFEPSSLEFNFYYNEKNSSITEIIYIGTCENFQSNYSIKEKLNFILRYLNSMQTLYPENYIFSPIEKRTHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Y6</accession>
    <name>A0A4Q9M2Y6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0175p0040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000175">
        <property type="protein sequence ID" value="TBU19911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Y6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2Y6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0175p0040"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU19911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19799" checksum="C673D9AF51F91FE5" modified="2019-07-31" version="1">MPFCREIVLDGFVFTEMFCIECNIFKNRSISHCNVCDRCVMERDHHCPWIDNCIGAANFKYFIISIYTTTTCLYFTTESTFRMIYSAFIPSFILPLIFIFTIIFSLAFIIFVALSFYYTMLIFCNTTAIQYIKNGFSYSKINPKEFLRFFCTFNTSYIESTPGTKTIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M497</accession>
    <name>A0A4Q9M497_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0051p0070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M497"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M497"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0070"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="322" mass="35480" checksum="57935772962A60D0" modified="2019-07-31" version="1">MIDNKTDDKKIHKLCVIGSGPAAYSACLYTQEYCPLLFEGKVIGNNGPGGQLTTTTAVDNYPGFPDKIMGNELVMGMQRQVMKSGKIEIVSETVTELGKEEGWFVIKCGSKVWYSECVIVATGAQARRLFVPGTNDDEYWQKGVSSCAVCDGWAYRNRNIAVIGGGDSAMEEAGYLSNIGSKVYLIHRSENFRARKDLLQKIENNPKVEILKNYVLESAGGNEFLEFLILKNVKTNEILRLEVEGLFFGIGHDPNTFFINKEEVKCDKDGYLVADEYMHTSIEGLLAAGDVQDKKYKQAITAAASGCIAGLSAVKFLFKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4E8</accession>
    <name>A0A4Q9M4E8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0043p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4E8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8830" checksum="BF495D0E4C5A194B" modified="2019-07-31" version="1">MFEETVIFKNEFLSFYRRRGLESGLNAEESVNGYGAKNLKPKNNVPLISQGNPLEEPTNNINEESDLEEKQKWLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5G2</accession>
    <name>A0A4Q9M5G2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0019p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5G2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0020"/>
    <dbReference type="OrthoDB" id="10592014at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020531968" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12485" checksum="6F1A8F4A17A1C718" modified="2019-07-31" version="1">MRVQLLVLLLTTTIYTFLGHTDSIFQSRFYSKDPIAAHVYDRVVDEGPSINKLFDPYIRNDMAIGASVKDNLAPIQLTENEKRLEKLNNPVTIDYLVRPKQMLLLMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5G4</accession>
    <name>A0A4Q9M5G4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0021p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0020"/>
    <dbReference type="OrthoDB" id="2190266at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="81144" checksum="BD1FB91C13A72128" modified="2019-07-31" version="1">MTEKDIYLRKNVTTPRLNRFVAKKDSDEDKETTISVYEPSISSLGPDFIIQEDNVDNKCVWCGSDGYDEIDYIEELLNEDARKDMLQMGMVLRNRFNYPECDFCASKNMSLIQIKKENDREEENEIKESEKADFNIKNDLVSENVSKKENDEVYKLTDVLNDLYGCTNTYKNTEVEEQTIIEENLPKKLVEPPHAVTNTIYHSYEVLNSKVPSQFSSLNDLKNDVTDGFVVRNIISTQIEVNDFESKEEIKNISCESENLIPKIIQVSLNKEIEKNMNLNEENSKEIMDFKEENIISSAKSDFSENIVKESPTYELKAASTSAEIIEKIDKPEAIGEIPNEPIISLSLDNKEDKNISEDIYKSDFDSVQDSTIKTGNTTMSTPGYVALGTSVYPVRNIEEIISSNKVQAKINKFFVDKGGEIIKITPKEKSKKKNEVSGNQQKANETKKNVENDKKIQKEEKLIKKATGTLDKNEEGFVIMKEAESRVSGPKTPKYENTKSDIRRFVFNRKSQQYVFIESVDNLNDLRSGSIVGKIQKRGKNGRYQLNWFNLRGNFLTCLNGKRYRACASHYANERDGDLVCPEDSNFFYTKKYSINILECKILIVKNHSFLNSLLTCPLKFYKKRNDDLIDITDSKIISLNKQFSNYNILINNGNEEFAVKIPILEFALECNGAFYFFRFDNSTIFLRWLLSISMRQGNIICKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JU28</accession>
    <name>A0A4V2JU28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1762p0010</name>
        <name evidence="3" type="ORF">CWI38_2612p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001762">
        <property type="protein sequence ID" value="TBT98421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002612">
        <property type="protein sequence ID" value="TBU06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JU28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1762p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2612p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="151" mass="16644" checksum="52C691950FB5DE52" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVS5</accession>
    <name>A0A4V2JVS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0033p0010</name>
        <name evidence="3" type="ORF">CWI38_0045p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000033">
        <property type="protein sequence ID" value="TBU05232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000045">
        <property type="protein sequence ID" value="TBU20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0033p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0045p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="769" mass="91191" checksum="B421E6CA78A1B710" modified="2019-07-31" version="1">MSLNSCIKNPEKHNIKKNYQSLFIFLICFTCFVHLTTVSFFVFNEENRVLDPNTSDLSYGTIIPENGFIESKNGEEERKNIKYNTLHCESVNNEIKYYIPNIITIPYRNNMLLNSNILKTSFESNQENIEILLKNVSVSALLLFLKLLDNPDIIVIQIKIQDFLDILMIVSRLNIKKSKERNHFLKELLKNFMFAMQNENQDFDFDSFYEGYNQREIERSILMDLLIYCFDYITFNDKSAQRSNFLTGNKYIRFNSLDILFNTFNVDEKDENIIFLRFDDQSIKKLYKMLNVKYLLDTCRFLLNITNLDLLDLIFSDLKTDENAMNIFSNIILHTKKLYIHYAGNPKRLFSKKQINVFSKNLKVLKFEFDYTADELKDILESFNCFQKLIINTRKCSFDQLRTVINFSLKNKSIICKLFPFNFELLNIDFDFLKLIPNNCTFYARNFKKESENTEVPIQYLPYLNKYLYSNKKDSKFLLDFVRFECSRYKCMYLNFENNSSPFELDNTALILLSCLDSIKTFSLKNIVITDELLLFILNSNTFKTFGAEKFVFKANFNFLSNNNAINQNLISFNLIDSFSDMDSRFLIFLERFRRVELFKLIWIDIKYSASYFKKIRKYIFGSITKRKKISLKCLKIITALDDDKTTNYLDFISNTYDFSGILSIYYHVYSITNIEYSFLSKMTSLELISIGIYNSSNYIDFEKIFTDSNIFGKIESLAILSNMIRREDIDFFKKFKCLKILYLSCEILEYATISYLKKNNLRNVNFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX39</accession>
    <name>A0A4V2JX39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1850p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001850">
        <property type="protein sequence ID" value="TBU10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1850p0020"/>
    <dbReference type="OrthoDB" id="2187603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="50791" checksum="A1CBD8C2DE983645" modified="2019-07-31" version="1" fragment="single">MLDRKYIVPVVDSDQFIYGDTDINNPKECLERINEILDNTELINQELEKLLFMTCTKENKEYYKIVSKLYDIGRKSLFNDESNDILLKIFEFVLSISNFRDKWILKLKINDIFVTNKIKVLVPQNYINIVFSEDCKNIVSLAKEYLEKEIGKNITRTKIAAFCVICSIELDDQAIIELEMLDENIFYFIAYVFSNSKTKYEILLSWLKNLKIEEIELNLLYLENIDSMKFIINELNNIKDNNVFVSIIKHSKSHKLIDVFFSRLYESKYLLEILLITYKDEDHEYTNSIFSKIFAIDNNEGEKMLKRFLIETKSKYFSAMFFEKCKNVDSYYIEACLICSNNIDLIRDENIIKVSQSHYFSFLTSEYVIYEKCLRKLKKIFDEDKFEIYDTVKDKKYFIKNLCKRLFKEQIIIEAVSIKKILLFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX44</accession>
    <name>A0A4V2JX44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1812p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001812">
        <property type="protein sequence ID" value="TBU10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1812p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="349" mass="41071" checksum="D69B8BA2FA8C8146" modified="2019-07-31" version="1" fragment="single">MQEHLPQKIEEQVVSISLEAAKNELSAVEKAKGLQNIYGDKIFPVFYKYFSISFLNHLSLPTNKYKESITSYNTRSNYVQRRKIDIQNDLNNHGIHYAAIKRKKENTVIKINNNVRDEDDKEKKTDITTSKNNIDSKNTNNDIKTYGNEHSSYSKCSKSRKKEIERILKSKKRKCLEEKSIKSDELTKLMISLEATVVEKPNFLSNEKLFELISSQLKTKYEISRKKYKQENEDPKRIKIVEQSKVDSINEDLEKNLKINFPDLLCENIFSFKIPNLSLLLLEFSNDIKETFKVLINIDFEFSKKIIKKYSLDDECLYKFFLQFKDTDNLEEYVDLIDKNFLLKYNGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB6</accession>
    <name>A0A4V2JXB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1360p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001360">
        <property type="protein sequence ID" value="TBU11142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1360p0010"/>
    <dbReference type="OrthoDB" id="2186513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43886" checksum="4F6019EE17AE1779" modified="2019-07-31" version="1">MINTFMIFIPLAYMFRGNSSNGIDQTTFVSEEISNISSAHENYRKSHKAAQMIFTEDDESTISCTSDDKNNLEESKYEDYSRIDEYESNEVPNNIYDSNLCGGFYYPGSEKRFIFANSPIFRVYFKLSRVKIAIESFKSITSDFQREINKKQINHPSINVLLFSLNMIGSFSDLSFRYIESYAKNIEDSLAFLRVGIKFLQNLISYAENYCDGFEKTLSELNDKCRIFLQEIIKGLDVECNSSKGVSKKSIVVQGGVIIQCKNKKRGDIKGCNRLEGVIIAQVLFKIEHSVAHSGINRMIALIGKKYYRIPRTFIIKYAKVCGACSRFNYLKKIQKIYMKNITNNYDIFMIDCVNLGKYADQKDGIVGPESNRHLYNAFPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM3</accession>
    <name>A0A4V2JXM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0796p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000796">
        <property type="protein sequence ID" value="TBU12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0796p0030"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="37609" checksum="5EE2B080F7F5E9E8" modified="2019-07-31" version="1">MGNKDYYKVLNVSKTATPEQIKAAYRKLTLKLHPDRHPNATEEEKKKLNTQFMEVNEAYHVLKDTEKRKNYDRFGTSDPQFTNSNFDFESFGNFPNFKFSSFKNFGSENIFGSENIFESFFDTHDTRKGKQKNAVEFVLKCTLDDLFSGCKKKYKIRRKLLSSTQTENNLEVVVKPGYKKGTKFKFKDQGDQLNDGSFQDVHILLDEVPDPVFTRNGNDLEMEIRITFKEFICGFSRNLVLPGKRRFRLEDGYITRIGDWCVINGLGMPLSKEPSRMGNLKVKVFVEDIPKLTPSQRQRMASVGYGVLSIRIMGSNIKGVNHRTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS3</accession>
    <name>A0A4V2JXS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0581p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000581">
        <property type="protein sequence ID" value="TBU12932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0581p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020584682" evidence="2">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="29800" checksum="DC8816F9FC982995" modified="2019-07-31" version="1">MQPKILSYFIFCFIFTGKIFSSQDEAEYINENVLSKENPKSEHDKKSCFLCEEGLCASKVSTELKCKEGDDTLYASNKNPNQAISSEEMVSNPDKNTKSELKEEMRVMFPASESNFSDLKSEIIEEKSETKKKTENYDSDEISASNPEVESREKREEKTKDPVAAISDDSSNSNDNSDTREEKKEPVNPLCSAQCDSYCNSETSKSEEETKKIESTIEIVDVQKNLVSKVTNEIFQGNIDQVDTSEEYDLSRTTSLRLGYTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU1</accession>
    <name>A0A4V2JXU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0520p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000520">
        <property type="protein sequence ID" value="TBU13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0520p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="12029" checksum="82539EF39F51F8C1" modified="2019-07-31" version="1">MELEENKTELFKEFIKVASSSEVLRYARKLNNEELKSFVQIIEERNNELKNKHSSLLENLEVSKNVVSQYLKVLWRRVPTEIHKHLADKFYSIHNEINDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX8</accession>
    <name>A0A4V2JXX8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0393p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000393">
        <property type="protein sequence ID" value="TBU13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0393p0020"/>
    <dbReference type="OrthoDB" id="2151624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="97748" checksum="F6F762620EBE174D" modified="2019-07-31" version="1">MYFLLFLKTIRSSYKYYDRNMNGVEYMRKPRSLKESWVGLLYVLSLGFLDIVNCASKSKNGNIIFGLLDLNWETGISKSELSKVKYWLSRSSESEQLGFCSGKHRFKCNNVSMPNLVCSLKISYQNHKPLRSFEVNYKEDWKVQFRVLNRFLLKDLDKLFLFNISMDVNCQEFEMFVKSVTFDPGFAVLNIGYGLFYRFLRLFDALDPISSIYLSKFYSDLLRKCLMGISSIDIMADPEHYRVRYFGDKNRYRLFMPFFSVISDSIDACFNPETSYLSLFKRTKHSTDQCFRYAINVSRLILKISISSLELLLSGFKSNEWSVFNWILSVTKISGFCIDDTEVTCSEMKILGVCDILNPETTIRSAVPSKTIPLGFFSFLADTNVKSIQYLKFVNVVPPFDYLDQNINKASVSYFEVAYSSIEECNRITALLQKMWEPNAFKLTGYKMNSDDINRILYSNIKILVLKECTLDVDTDWKPIRDRRGEFKLIGSLKQLNISSSIFPVCLVQLFLMSAKLENIYLNSLKFTACLSFDPFSNTKRNLDCLEADEYIPNECLNTFFTGEISVNSLYLRGTADFESVRFIFESVNLHKSVKYLNLSKNSLTVEHLNLIANFYCLKRLSLSRSLPSSMEGLIHSKIFENITHLDISHNDIFSQNSVYIIWFTNLKALDMSSVRIGCYILSSILSEKLKNSLSYLDISGVDLSLADFKCISDCRNLRNLIFSYGNSCPLTTYSDVLKTAYVREKLSILRIETTGDIDIDDVLSLADFADLSGVKITCRTIINERKRELVVFNFKNPEFRIQFVLKIYFVDKFIEEIFNNLFKLCYCSFTYEKFLPCINFSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY49</accession>
    <name>A0A4V2JY49_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0220p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50907" checksum="6AD41370149E8ACC" modified="2019-07-31" version="1">MNNSTSNSTSPSTTNSTPQSQQHSQQQSQSQHTQIQTQINKKLKKALSLTKKHFFPFSLIFSQDYTSAANLYNEIANSYISINNTLKSYKYYNKASTCYLLDNEKGLSMHCLIKAGEIIYKKNKILSAYTYIKGGDIGMEIGSYCISGGRYLEAGRIFLEIHKSIDTGGDTGYDTGYDIGCESEGYESDNNNNDISSNNIYNPSITDNTNNPPHTPSTTTSTNHFLFKSLLAYEKGVMAYKLANMKNNLRGVLNELIIILLKLKKYKKAGNIFIKMICDERKYNNSFYMLCSVMCYKVSKSGVYCENEYVCNGSREGGSIIDNGKDYSKGKDYIKDRGSNQDNKDIYTDIYKDNNNIKNRNKKNTDNNNIYTDIYKDNADIYGDEEVDVGGCVLQLEEEELKVYESLGTESYEEVCDKYFRCRKVDEEILLLFEEVERINRPENDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL0</accession>
    <name>A0A4V6MVL0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1396p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001396">
        <property type="protein sequence ID" value="TBU11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL0"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1396p0020"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="392" mass="46214" checksum="C98372CC70C5D987" modified="2019-07-31" version="1">MDRSTETELFLVTSISYTSMLAYKCMNIQNSLALELIFWILPQYIAICYPDWIVYLYIMLICIIFLKRKNLFVKYKEEPIKNYYPILDSYRAYLMLMVVISIFAVDFNFYPERFKKSSFFGLTLMDVGIGSFLFNSGAMSVKMSRIKLIFNSLIMIGLGFVRLFTILYFNYTVDITEYGYHMNFYFILGAVYFIYGIIRSKYNFKIALLLTVIYEYFLRVKNQDVFIFSEYRNSLFLKNKEGIYSILPSLTIFMFSSEFGNIGFSKDSNKEKYMKILGMSCMFLFIYYISNGYMIASRRLGNLTYVSWIVGLHSLHLFLSLTVTAFVSFKPLRLHVWVSKNMLTLFLFSNILVLIGNLLFDWKKINEMLGNIVNISYIFISIIIPYIFTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN0</accession>
    <name>A0A4V6MVN0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0536p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000536">
        <property type="protein sequence ID" value="TBU13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN0"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0536p0020"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020773627" description="non-specific serine/threonine protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="149"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="523" mass="61375" checksum="383E5FDF57867652" modified="2019-07-31" version="1">MKSVGWRLFLINSVVLIHATILDRGFGSRVHQTSRNQTIANEFCTFNQTDTSETTYYYSFDRDTCMSSTSHQDSMIEETTINNSNYKESGIGSSLMCHETLLSRIDSISPIKPIAQSTPLINENKYQNSSITTNKIMVLNINQLKSYGYTEISYISHGSEGWVYKVYNRMKNETQAVKVFIGDKNLLYNVFDEMMIRKNFNHFNLLNTKLIFDQDLTFMEMDFYQFDLSNYRLSTSNFIDLNCRIILKQVIDGLYHMHLCNVIHNDIKPNNILINESLDIKITDFGIACYKDRLIFPFQNMKSFTEYKTYSPELKKSIAYTEKSDIYSFGVLIFYLYFDSLDLNTRAFDTTGDDAKNIFAACIKKNPEERMSAEQLKMHVYFDILYSDLFCFSKYKNFKFTSDTKIKIEKNEKKLTIKGENFEYKIYCCCCEETIEKYTQAIDRLDKLDTDTYPIDYVSKIRYLVVVNNKTEIIQSIIKPQLKHISNAFIFISDYQKSLKSNDIKIMMGRRTKKRKRRIKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVQ1</accession>
    <name>A0A4V6MVQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0618p0020</name>
        <name evidence="2" type="ORF">CWI38_0046p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000618">
        <property type="protein sequence ID" value="TBU01830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0618p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="116" mass="14008" checksum="04149242B4E5EEEC" modified="2019-07-31" version="1">MYKRVFNHLYLERLAIYLSEIFNGYLNEPAIEERILPKCKNIASECDKITDSKQKHEEFFEKIASFSRADIIHCKRLFLEKYKNDQTRNQFFDQLLEFSSNNNFVSQTAFYKNIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWW5</accession>
    <name>A0A4Q9KWW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1453p0030</name>
        <name evidence="3" type="ORF">CWI38_0562p0060</name>
        <name evidence="2" type="ORF">CWI38_1757p0030</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001453">
        <property type="protein sequence ID" value="TBT99134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001757">
        <property type="protein sequence ID" value="TBU10442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000562">
        <property type="protein sequence ID" value="TBU13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1453p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0562p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1757p0030"/>
    <dbReference type="OrthoDB" id="2190729at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="79" mass="9255" checksum="B208DB0B64D1A644" modified="2019-07-31" version="1">MPLSIEMIIDANNLEELYTQCLNGSIKEVNTDKSTTIRYIRQFAPIKYEIVRDFLTDNEIISELKRFGRNSILKNICKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4D9</accession>
    <name>A0A4Q9L4D9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0653p0010</name>
        <name evidence="3" type="ORF">CWI38_0709p0040</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000653">
        <property type="protein sequence ID" value="TBU01681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000709">
        <property type="protein sequence ID" value="TBU12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4D9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4D9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0653p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0709p0040"/>
    <dbReference type="OrthoDB" id="2195822at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="295" mass="34319" checksum="2D9B665CD078C8CC" modified="2019-07-31" version="1">MLIAYICLIRTLSTDVLNTPLNITLISSDQVLAAYEKQSIVFTEKEKFKNIDYDGLSSIEKNGNLYRLRFNKLFVCIDGNTKELSLCPSTSLYTKDFQIFRVGKCTVISSESKCLTVLKNEVFPFKNTFKGHFMSCIPNDKQQCFDFKHNMSDESIKSKNESDSNANEMSSDANSEQSSENNTYDDYTKGYNEKDSNRQKKPKQKSPKPFPNKLSSTLPKKKWDMDYVNKNLDDAHHLVAKTNPELDISTKRYYPECFYGYDNMTMFLNDVMPSLRKMKKKYCWHNMNQDSWHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L930</accession>
    <name>A0A4Q9L930_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0213p0050</name>
        <name evidence="3" type="ORF">CWI38_1596p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000213">
        <property type="protein sequence ID" value="TBU03906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001596">
        <property type="protein sequence ID" value="TBU10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0213p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1596p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="143" mass="16327" checksum="DFD98D278B25202C" modified="2019-07-31" version="1">MEEMLSVLLFMFGIEGFLIYNYGSGLYLGVEKNIVIGVPLPLAESFDIEYTKDMPEYLSVYITSLKMELAVTPGHQRIAIAMPYSYDDFQIVLDEINMYRILHNGMCLTFTAGIFSREVCEDDDFQLFEFEDSSTSISGSEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD24</accession>
    <name>A0A4Q9LD24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2704p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002704">
        <property type="protein sequence ID" value="TBU05797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2704p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="49378" checksum="C55F9A594B4BF6B1" modified="2019-07-31" version="1" fragment="single">NIKGVNNSGTNIKGVNNSTNNIKGVDNSGSNIKGVNISTNKQHPLDFSDEHVFEILFFPLYDCNILNILIFIYGIDRIRNIGILMLFNKYKYKYKDIMRCVRSVLEDKREILMYCYNFKEFIGREVSVSMFREGYKYEVCKWYKDSVWDDEGVWDIGSDRMGKHGLDKRVGNMAPLNNRIGNMGPLNNSIGNKTHLGNNRGNSTPLGNNAVNNTPLGNNTVNNTHLNNNSINNTPLNNNLINNTPLKINLLDYVLFRESKYSLVDIECRGVLVREEIIITFNYNNTLSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE90</accession>
    <name>A0A4Q9LE90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2684p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002684">
        <property type="protein sequence ID" value="TBU05896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2684p0010"/>
    <dbReference type="OrthoDB" id="6918874at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24814" checksum="A15F18D44C7B7511" modified="2019-07-31" version="1" fragment="single">NEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLINKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIRMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIIRSEMHEEPIPPLKEAKTEEDGAKNFQQKNKAPLISQGGTTLEEPTNNINEESDFEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFR2</accession>
    <name>A0A4Q9LFR2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2506p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PITK01002506">
        <property type="protein sequence ID" value="TBU06794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFR2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2506p0010"/>
    <dbReference type="OrthoDB" id="2196026at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="126"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="360"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU06794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="657" mass="75597" checksum="E6CB182028350AA7" modified="2019-07-31" version="1">MDPLDLFFKNLKKNISNKKDENNFHTEIEVSSEHEEIKLEKTDMKRNRNNIQAIIELKSLHDIDNYKTKNIISSAMYRKKNNISFLGSKNILPIFNFESLNIPFKFLDILNSKKIFRPTPIQSQVIPILLSCNNVVGVSETGTGKTLAYGIPVILFANTFKELSTIILTPTRELCIQIYENIKLFARPYNLNVCSFYGGTYLLNDLKKIKKNPNIVIATPGRLIDIMKTNKGKYFNVSNVKTLIIDEIDRMIDFGFLPQINQIISNIKNTDLKKAENLNNPNFRKDTNSVDCKNTNFKKFEDLHRSSFVVGAFSATTSYKVNSFMLKNFKNIFSVTVGKKYLSLPTAITHFIFILKKTDKFSKLLSFLNQNQIKEDSKNDESFLIFVNKKETSEDLSQKLNNLGYLTLSLNGNKDQNDRESIINSFRNKVCNILISTSLCSRGLDIDGLKNVINYDCPQTKEDFVHQVGRTGRFMEGKAYTFTCEEERKFSVNIYEVLNQNDCIDIEEVNDLNNMECTNECGIVGRIENGIELGKVENLDKLEGKPNIKVYGFNNLRYFVEEYLDLIEKGEETIFKGYKGRGLNKLTSQLEGKKRVETRIMKNEICNENENFVFESKIETNNKVSMIKKIVNEMAVKVSETLPDTKDKYDDSKRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFY2</accession>
    <name>A0A4Q9LFY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0265p0010</name>
        <name evidence="10" type="ORF">CWI38_2652p0020</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002652">
        <property type="protein sequence ID" value="TBU06051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000265">
        <property type="protein sequence ID" value="TBU17871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0265p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2652p0020"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU06051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7242" checksum="057B650E884880AA" modified="2019-07-31" version="1">MSFTSTFIAVTIFMFILVFLVFKVANLTKKKDRDVIRIAGTGVIGSAYLAWAVTYMAHYHPAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGE0</accession>
    <name>A0A4Q9LGE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2443p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002443">
        <property type="protein sequence ID" value="TBU07159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGE0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2443p0010"/>
    <dbReference type="OrthoDB" id="2192511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="560"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU07159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="833" mass="92597" checksum="C089FB59A4E70A7E" modified="2019-07-31" version="1" fragment="single">EQQGFINSTNEQQGVNNKYSEQQGFNNSTNEQQGVINSTNEQHPLDNSTSNYHPLNTSTSNYHPLNNSTNEQHPLDNSTNQQHPLNNNNRVGIITGDTKINVKANILILTTEVLRNMLYTNTLPINTQYVIFDEIHYISNKDRGVVWEECLLLLPKNITLLLLSATTPYPQLLGNWIGRIREETVYIVSTSKRVVPLIYYVYSGEDIIEISKGKYVGRGVDSVRGMLEGSYRGSNYKGVSDKSRLEGVSDKSMLEGDSDKSRLEGVSDKNSRLEGDNTNSNTLHPVSNKSNKQHPINISTNKQHPINISTNKQHPNNNKSSKQHPVNNSIHEQHPVNNSIHEQHPVSNNIYEQHPVSNNIYEQHPVTNTPNTYHSVNNNTNTSNSQHPLNNNTTTINTLLHNPSYPYPLNILSIAILNNLTPTLFFCFSKKRISKYTNTLYSFNINLLNNKEKEEVESIISKYIKGCKYSSSMRGVSYSSSMRGVNNSRDMLEGVNNSRDMLEGVNNKDIRLEGVNNSRDMLEGVNNKDSRLEGFNNKDSRLEGVNKVSYKQQGVSNSIDNDPLINSTDKQQGVSNSIDNNSIINTPYTILLNNTLPSSDILTLPQFILFKSLALRGIATHHSSLIPFIKEITEILFNKSLLKIIICTETFSMGVNLPVKCVIFDSYYKQGKLLNNSEFVQMSGRAGRRGIDDKGVVIINGIRGVRDKGSNIKGVSDKGSNIKGVKDKVSNKKGIEDKGTNIKGVNDKGNKDKGVNDKGSKDKGVKDKGSNVKGVSNMGSNIKGVKDKDTKDKGVSNKGSNIKGVRAKGTDAKGISNSTDKQHPLNNSTIKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGJ1</accession>
    <name>A0A4Q9LGJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit 8 of transcription factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2605p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002605">
        <property type="protein sequence ID" value="TBU06281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2605p0020"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19987" checksum="5EFE1FFF0B1054D2" modified="2019-07-31" version="1">MEKILEKCILEELKRAGYQKFNAKALYMFTQTTIAQIKTNCNILSSLTLHSMRSRSTLLDVMNLIKLTKIDYSNVYNRPTVKYEVEEESKPIQFKSSISCSAEKFIHIYDFMPDFPPVHTFKKSFLKENRSEDKSEKVKQRIEQSLRTESSLLKIIACSKGLPKRINFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGM3</accession>
    <name>A0A4Q9LGM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2492p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002492">
        <property type="protein sequence ID" value="TBU06876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2492p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="780" mass="86071" checksum="81691054BE0065B1" modified="2019-07-31" version="1" fragment="single">NEHNPFILITNSTIIILKGTLGINTHISIRKVNTLQSLTILLLIKQSFITPDFSYGIPTLLTPFNIYLKIYNIEYTTVEYDSVVKGVNNSTYNYNPVNNSSSKQQGVNNSTYNYNPVNNSSSKQQGVNNSTYTYNPVNNSGSKQQGVNNSTYNYNPVNNSSSKQQGVNNSTYNYNPVNNSGSKQDPFNNSTNTNTPTTNTNTPTTNINTLILSNLTLTPSGLQLFITKITPFYYTNTPLRLKVSFIINPQSVTTRITISDCNIKLKIKNINEIQSLVNYTLKEIKKYTFYSIENRISIISLILFDNTIIICKNNGSYFIKVLLNFISITIENEIICKCVIGVLYYDNYLLDYYPLIDQCNINISVINEIISVNSKEVIRGVISDGLLREIRYFNSLGVKNILYNYSCSDMVIRTISKILKVVGNSRGVSSRDSRGEGNSNRDSKEGVSNGDMVDGKQQGVNISISEQQGVSNGDMVDGKQQGVNISTSEQQGVNISTSEQQGVSNRDMVDSKQQGVNDSTNPLHPVNDSTSKQQGVNISSNTTNEQHPLSNTTNNNTPTNTCYFTDNIATLTINNTVLYLPLNKEGTNLYTFNTSLLAIEITLSELKRKINIYNPVIIKNMTEFKITVGLSNNYNDILTPFSNSTIITPFNDSSLLLKGCYLLLQPFGYKQGNKGVNISNINNTPTSIYFTCNDYRAMHMVLIVDVIQYKCSDSNIGFSIGSGDSSMGLGIGSGVSSMGGNNTPLNNSSVNNTPLNKSTVNTPLNNSSGNNTPLNNSSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH96</accession>
    <name>A0A4Q9LH96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2499p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002499">
        <property type="protein sequence ID" value="TBU06835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2499p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15730" checksum="467A52D59B9F5FE8" modified="2019-07-31" version="1" fragment="single">LPVINPDSFSKSYLKIITLILIQKPDSKKEKEITSTRLGLWLVSGLGYGNMSSTETKDRVWDKKVFEKIICLENLLLEGKETAEKNKLVRVVKNLVGELKKNIDNHIVKKNCAGKKESGENNLMFTIEIGIDLLETKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI48</accession>
    <name>A0A4Q9LI48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1041p0010</name>
        <name evidence="2" type="ORF">CWI38_2488p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002488">
        <property type="protein sequence ID" value="TBU06901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001041">
        <property type="protein sequence ID" value="TBU11778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1041p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2488p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="15764" checksum="423CE68A6716DF20" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKP7</accession>
    <name>A0A4Q9LKP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2213p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002213">
        <property type="protein sequence ID" value="TBU08853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKP7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2213p0010"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="302" mass="34559" checksum="6130A0F919557F9C" modified="2019-07-31" version="1" fragment="single">MKDINKEINKSKDDKGNEGSRDKIKEDKTKGKEDRNKEDKNKGNRNKEDKTKEDKTKTKEDKTKGKEDRNKEDKTKEDKTKGKEDRNKEDKNKGNRNKGNRNKGNRNKEDNTITNNTFHSKYFSMYKDSLINKQSFFKEKALKHLTWHIPFTQTYNEEFNTANSQWFIDGKINACYNCVDRHLVNDTGKEGDIGKDSRLEGDIGKDTSYKGVSDKDSSYKGVNDKDSSYKGVNDKDTSYKGVSDKDSNMKGVNDKDTSYKGVSDKDSNMKGVNDKDSNIKGVNDKDTSYKGVNDKDTSYKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNZ9</accession>
    <name>A0A4Q9LNZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2055p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002055">
        <property type="protein sequence ID" value="TBU10064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2055p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="370" mass="44182" checksum="D89B58886E5842BF" modified="2019-07-31" version="1" fragment="single">IDLENTVYISDLENQLKFFQTYNFQNYLTKVNLCLFREKYDTTYFAKIFNFNLIKFLKIDLKNVQNNFLVSYKFLESFEALRGLSFENIKLTNKLFEVILCSRKLTTVLFDNFMVFDENELINQNLFNNSILFLGFYNLNMSLNSLFFLYLSKFAGLKRIILNLHHNQSLDTNEYCFNDEVRYLNIPKPKYHRYLPSLESLKYGNFFFAKNQTSSSILKILYHLFNLENLIELKYNTGCLYKEDIEIFSNLKSLKYLKLSIQNKSSDVEILRKILRLNISNKIFKLDIYAYKFEISEILSISNFKKLKILKLTFYSDEIIIRKNLGILYRMNFIKLDIYKFDINPLLDSYGYAKKIIFSSSLLNHSHIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ9</accession>
    <name>A0A4Q9LPJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1832p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001832">
        <property type="protein sequence ID" value="TBU10349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1832p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020988243" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29977" checksum="2E0E52E15C7F5581" modified="2019-07-31" version="1">MSINLFILILNTLDIKYVHISELNETNVTDYCLVLTNIKKKVEEILFFKVYIFSEIIRCIDANLNFINIKKIVFIRSKIENYLILLDYLKKISEFIFFEETRPTKPKTVTQINYPENLKLIKEIEINIQRHGYPEYSLKKLVTYLKNMPLENQNLYVRFFEANENTSKFKLLEVVNIVSKYWKIGCYFDYKGTFYNISITLTNLNLYQFTPKETILEENIKKLRITDSKITSNFVADILNINKLKSLTIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPS1</accession>
    <name>A0A4Q9LPS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1948p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001948">
        <property type="protein sequence ID" value="TBU10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1948p0010"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="527" mass="61003" checksum="05C0B291B516E56B" modified="2019-07-31" version="1" fragment="single">MFEEALLTLAFAIYIPKTTLFDIFKSGKYIKRISSTVKPTLTDKNKMNRLKFCLSKVNLANNRDLLFDDLYDYVHIYEKWFYLTKVKRSYYLMLNDEKPKRNCKSKRFITKIMFMAALALPRYDAHRKLYFDRKIGIWPFVYQEPAQRNSKNRVKGTMITKNVESVTAVHCKNMIMDNVIPAIKSKFPPAYKKKTIYVQQDNAKPHFFDNDADIVALGSADDWNIKYKAQPANSPDLNVLDFASPHTIDELINCVQDAFYQLEANTLDKVFTTLQACMEPIILADGGNGYKIPHLGKGKLRPEGRLLEKYVLSKKHTIKPNQISSPSEMKNSSTEQKTLIYCQTNSSDSFLKELVHLRSNTKTISISKKELHDHLEIQKIISKNKSSLFITGYKSKNNEEILKIGRLYNNEIIESLDCKILSNKKMKDINYHGPIPGVIYGIFFLGINDERLENLFSDIFCQKVKKINREYFNYNLIISKVENNKYVLKLVNINKNLDVIDVGPILEFEIINSFMCDDDVFSGFCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQB2</accession>
    <name>A0A4Q9LQB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1792p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001792">
        <property type="protein sequence ID" value="TBU10397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1792p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="15048" checksum="B9ED860296A9D5AE" modified="2019-07-31" version="1" fragment="single">IQVYDILQEEYRIINDLNNLENLYIHLNTKINIPILNIFENISHISKIVNITLDIFKCNDLDPLVLRKFKNLKFLNLYCYEIDTTSIQILDSQTVIGDLIIRITTYDNTYESFTERNMLYELRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM4</accession>
    <name>A0A4Q9LQM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1544p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001544">
        <property type="protein sequence ID" value="TBU10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1544p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="699" mass="83345" checksum="61722CFE53724062" modified="2019-07-31" version="1">MKISDHVFTYENKHFISFEVFKSLFDSNTSKNQCGKIECNFELEYILRITKDISALPDTVNYNHFESLLILLKYLKAVADKNLSQLLQGIFFKIFSSKNIVDSTNTDARIEEVFCKNIFVQSESSLKEAIISAFINTLMLKHVFCDENLIILSIKNEFFDTSLFNEHIPYKNLLINNFKVFSILENHLKNPEILKIFKVLLKEININSLIFFRYQISKFKYKNHIFVFPIHIFKAITVSNVSDSTGIMIYELELAVDKNLEYFTLKNLSIDSDDIISFLKKHKVKGLIFDNVRRCSGFNGFESFMSLQETLEYIEIRNFKMKFNWWINFCKKLNVRKVILIFNSIFIAENFINEFITLNFSINFIYFEIDFCYSKLSKEFCDSLKYLRFLQTLKLTNYESNINLEPYIVNVMKNMPELKNVTIYHKYFSNKFYRLLFQKPKIRVLHIRNVILNKKTLKLNSFNNYKYLTQIFLSNLKIDTFSLNEIFKLENLNVLSLRFCDIESIEKSYYEKFIPRNIKSLYLYDSNLNNTKEFNLLNELKFLENLHLSSRKIYSNYLSGINQNCNLTLKTLCYKYGICDINDLNRIMNLQILEELNLYESRFVNICFYQLGENCRFLNSLRILNLWGVYMCLKDFEYLRNFKNLQNLRLSFSGVRFVQFNFNVISLSRASSFFKQIYNNFNHQHTSTFLYEEGIEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ0</accession>
    <name>A0A4Q9LQQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1524p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001524">
        <property type="protein sequence ID" value="TBU10829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1524p0020"/>
    <dbReference type="OrthoDB" id="2196291at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="25542" checksum="BC1B923F5D043732" modified="2019-07-31" version="1">MPNSSDYYLPSPQSYEPIQNLKKNIKKKKTKKRKTLGKYVPFKSIYEQPDISKLTPRQQLMVLRYKNAITNAESDNFIVIENSYQPQTFERKTRLNIKKPTDNTENLNNPNLENPAIPINNNISLENRISPNFEIKKHKCDKKLKMCSKCTKDIKNILIFLKTELAVHECKFKSIIFMEIKKLERILNHKNDFIFFKNETARIIDVISNLQCCSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR48</accession>
    <name>A0A4Q9LR48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1455p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001455">
        <property type="protein sequence ID" value="TBU10968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1455p0020"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="375" mass="43794" checksum="AF0E696CA69637E0" modified="2019-07-31" version="1">MKIIRGYITDYEEALLIVHGIRLGLLPITKSRLSISERKEIRSGCIYCFVESKSGIKRWTDGKIWSPSMIVGKFLMYKEVPQHLSKTGLKKYNSSIYSSISDISENENNRDENNKNEKYENNRDENNRDENEKYENSMDKKYENNKNGKDEKYEKENNKYSKDENKNEDKNENSKYNKDENKNENSKYNKDESKNRGKNEDNKSNTNTKNNTNPNTNTDESLAVTLVSLNRSFYKNNDIFTFYKKTISVPFGNEIYHIISYFQPVFAKYSLSKIPFYINLGELINKNNNLLNDSYVCKIREENCNFMEDVYSFGKPTQENTCACLNRKELEKIADIRSERVSDKKGVSDSRSEGVSDKKGVSDRGVYYFVLRGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE2</accession>
    <name>A0A4Q9LRE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1387p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001387">
        <property type="protein sequence ID" value="TBU11099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1387p0010"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="35539" checksum="420B168087E6B5F9" modified="2019-07-31" version="1" fragment="single">MKKANTFVYTVGDHIMDEGIKKEGLFRISGKYTYYKLMPGVLAAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQTDPSIIEYIVPLIIFSITNENRKMLIYLQKIFRKVNQYSKDNKMGNAVNLLFKQGKQDLEDAHNFSPAILGNNPKGKKDNQAYLALIKIFKIKYGLEKDLVSVNESLRSLLKESVRIFEKNSSDRRRGHDNRQDNNKQANNKPEILTQNTILIHFYEALDNSLRVNNSDTSHIYESEKYLTSDFFSNRKILRTKIIDLNIFLLEFLIEEQINQYEIYIYNEYLSYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX0</accession>
    <name>A0A4Q9LRX0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1280p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001280">
        <property type="protein sequence ID" value="TBU11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1280p0020"/>
    <dbReference type="OrthoDB" id="2187956at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="949"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="818"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119382" checksum="82796B1376A3E0D4" modified="2019-07-31" version="1">MTLNTNDTFTSKQEALTAIKEYTSQTPYLYTSQTSTPKHHTLHCKGKDDFNCDAHISISYRKKDNLYVVKRIKTIHKCPLDIHTNSTSTLQYLKQEILHLSDPRKEQRIGDIVVVLNKRNIKVGYHTVWKALNYEKYCNDKDMLEGMEGDMLEGMESVNNKEYDYRGVSNKDSKLEGVSNSTNKQQGVNKLSSEQQGVNKLSSEQDPVNKLSNKQHPVNNTTISNSTTNKQHPLLSNNTSINSTTNKQHPLLSNNTSINNTTNKQHPLLSNNTSINPITNTLYPSTYNTPSSLHLTPFLKQSLLSFKSELLSLNTNIICYTSNTNIYISIPHTLLYTRPVIELKVYERTYNNIVIGHVIYSVLYDTNDKPIVYSFMVSEGLLSDNLKEYVKYTKGYKGDSNEGLLSDNLKEYVKYTKGYKGDSNDYKGVNNKGSDVEGVNNSSNDYKGVSNSTDKQQGVNKLSSEQQGVNNSPYKQDPVNNTPTTTNTTNTTPTTNNTHTTTKNNTPLFFIVELDNTIIQILESINFPYFIKTRDICKEGYNYYKDKSVILKIWEICNRPNISSSYSNLYSDNTFNSSLNNSTFNSKFNSKFNSSLNSTFNSSLNSSLNSTFNTNYTTPFNNSTLINTLNTNYTTPFNNSTLNNTLNTDYSRIDSLMSYMSYNSSKYMCMLFPYPLFGLNNLCELDIEYIYYSVYNLSFYECVNCIIKMCSEYMKVRGVKCEVVSNRIIKGIERSKMCSSDINMGSGGVNMGSGGVNDSDIMMGGVNDRDIMMGVNDRDIMMGVNDKEYGYKGVNDSIDLLEGVGIESNTIEGVNYSTSKQQGVNDSTNKQQGDNDSTSKEEGVNYSTSKQQGVSNLSDKQHLPNNNTNKQQGVSNKSNIVCEQDPLNNLSIPYNNKENMNNPYNDKENINNNNTSINNPYNIKENIIIPNIINNTDFKGKVYDNGNIYIVNLKECTCSCGKYQLLLIPCYHAIYFIRSIGDNVLRHISCFYSEEFNRMVGYDIIPVVNEVVKVPCDKVYFNRKPGRPKRVRVEGLGLSKGVLGVSNYTNVYKGVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS84</accession>
    <name>A0A4Q9LS84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1370p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001370">
        <property type="protein sequence ID" value="TBU11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS84"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1370p0030"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="438" mass="52445" checksum="A69CA128DD0B8728" modified="2019-07-31" version="1">MEELYSYIYVPRYLETRIFIEMKNETKKFIRKFNNILYTILCLFYKRKCISNVQIIQSFTVLFGFLLFRILNPAEIYHYIRLQGVMKLYVLFNVLEVADKLVGVILNDVTKVLLSISYFNISSTKTCTCMKDSKYRKDCENFFKNNIDIPPMKDNDYNNNTCYKRDCEDFFKNNIDIPPMKDNDYNNNTCYKRDCEDFFKNNIDIPPMKDNDYNKDCCYKESEMCVYDKEIYCEKPLKYQNIKEWNLKYLCICSVYFIANIIQTGILYIQYITLHVSINGSRNNLYSLLISNHFVELKSNIFKKMDTKSLFNILSSDISKRFNIFIYLIIILFSNIDDSEVNESVVSSFNRMIYPMCVVFGSKIFIDCLRHCYICRYNNIFYNVYLNYKKDESVKCEQIALNILFLTVLSQVWCFKYLDFKFLVTFFSLSVGIEWFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI2</accession>
    <name>A0A4Q9LSI2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0436p0040</name>
        <name evidence="9" type="ORF">CWI38_1156p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000436">
        <property type="protein sequence ID" value="TBU02664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001156">
        <property type="protein sequence ID" value="TBU11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0436p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1156p0010"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU02664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="199" mass="22964" checksum="81987C4F1E15A3F4" modified="2019-07-31" version="1">MNELSDYKDIYIDRTDFKGALTGYIPGDESLLKELGINFGTIKKESMLVTRVFNRSHINYGFLESADISGPLIFIILFSFFLLLNGKIHFGYVYFISLISTLFMFFLLNVMNNKWIDFIKCCSVMGYSLLPVLLYSFLSILMKYLDVWIRVIVALGVSLWASAVSSLIFVNYLEISNKLFLIWYPLFLVYACFTLLAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS9</accession>
    <name>A0A4Q9LSS9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1008p0010</name>
        <name evidence="9" type="ORF">CWI38_1164p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001008">
        <property type="protein sequence ID" value="TBU00430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001164">
        <property type="protein sequence ID" value="TBU11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1008p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1164p0010"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="178"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU00430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="236" mass="27104" checksum="34C1C47C1DA2890C" modified="2019-07-31" version="1">MKALSTEEIEFTRKCILENLRVNLRKMNDERETVFMESTIEQSDGHLHVVRGETEIEVSIRFIETEETLFTLERIENDTTESSIAPESSKTLDSSNIESNEFFLNLIQETLKEFLKNYKIGVKVEAVIFKDDGCVFDLFFLALQKIFSCINIPIIENLDRLDIFCDIETSLDLPKPKTYAVYENIFVLDPNKNEELSSDGIIHLLVDSSKNIHGMFLENSKLIDPLVLIEAINNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT40</accession>
    <name>A0A4Q9LT40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1201p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001201">
        <property type="protein sequence ID" value="TBU11447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1201p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="33442" checksum="0034391DDFF029E8" modified="2019-07-31" version="1">MYDGLSESQRKKIASIVDFYFDHIKTYTDEYLHELLLHFSTLISTISCAANLENNMECSHEFLDHKNIFTHASFESLFPFFLSVKYYNPKEILKMYELTFSVPDTVLIEFSMLLFSFLCFKEELTNSEIVLRIIVEFLFLTDILYIEFNKCKNTERVKSIENKFQTFLDSSYPCHHTVHEDVVSANLSLQHISLKTSNLIEISVIVETFSDQLFLDKLNTAIITKLKKTVNSTSNEGNMREFILYIVKTEKINNVPSTEKLQKEVHGEPSNILHNEIQEDVENEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT85</accession>
    <name>A0A4Q9LT85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1078p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001078">
        <property type="protein sequence ID" value="TBU11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT85"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1078p0020"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="22897" checksum="BC8285E2D3E4DD09" modified="2019-07-31" version="1">MDPYKVLRIEKGSDITVIKKAYKKLVLKYHPDRPNGDENKYLEIREAFEYLSKDTVESETINVENIINSYKNGPEEKEEIKYLYMKYKGDMCKIIDNMILGEDTDETRLRIIIDELISNKDIVKYKKYCKKITSNKRRMKKKEKEAKEAENWAKEQKIDLNESLESYFNRKNQERKAFLENLEEKYLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC8</accession>
    <name>A0A4Q9LTC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1518p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001518">
        <property type="protein sequence ID" value="TBU10845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1518p0030"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="43260" checksum="8FE01B87887B06E2" modified="2019-07-31" version="1">MNTQKWSSPFIFNVWSDTTEEWTDQDWRVVGYNSRSRSKSVTYEECKDQDWRVVGYNSRSNSSKDSIINKYTNTYSNTNNTYSNNTYSNTNNTYNILPQLRRLSEPVITNNMSVSDILSLNNNLYIIEFKGGRLDVGYFTGDTNRDTNRDTNRDNDRDSNRDTNRDTNRDTNRDNDRDNDRDNDLYNSNRDTNNNQQSNTNQLNTNKQPNQQSNITSHFITNAYVILEADRGEDLGKIKCKTSKEKYKRLLSRIDKNESVREVHPKRIYRLAEGKDLEVIKIKEELERNALLSCKERVRERGLGMEVVECEYQWDMNKLTFYFKSDKRIDFRDLVKELYKVYKTRIWMCAVEKSKNYYLSELCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI1</accession>
    <name>A0A4Q9LTI1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1119p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001119">
        <property type="protein sequence ID" value="TBU11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1119p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22599" checksum="C45CC8F23FAB1AC8" modified="2019-07-31" version="1" fragment="single">IRCNRPDIFISDKRQNRIALIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWESASMGVIMRSEMHEEPTPPLKEAKREEDGGKILKTKNNTPLISQGGTTLEEPTININEESDLEEEAVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ2</accession>
    <name>A0A4Q9LTQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1366p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001366">
        <property type="protein sequence ID" value="TBU11131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1366p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="52689" checksum="9976DFD56A295F75" modified="2019-07-31" version="1">MKYILIIILSNFCTKNPIKSKKYYINTVFDVIKKEIYKQYIEKSKRIDKICSYEYLFLESKKCFNMEASEEIYKFIFAKKVKKFQVMISLVQSNEMYNGFVFNISISIFGKRFIGFGFNDSFYRVRYKNICRKSYSNFTNTEIKEYFIKKHILRFIFWYINIIKKIIQKMILDRNKMSILTIFSDIVYFEDCDRDFLSRLLIRQNYTSDNDCYLLINSIKINDKYEETKNNKTFLEYSFTNIIFESIKNISFERVEFSDQLLEDEQNVTVYNKIVAKEIIKCGENTYLNIYDIFFSSFKNGLKMQNREIENLDVFGYSSANIDAITFIKVNTPGKSIKTNKANKSNKIIKIKKDFKEICCLIIRNREFNLEYNIDISYKVYNNEITDIFVNQRIPGFYAHHTLKDKIACILRFVKEHEIYNFKLVYWDLSKSKKIYAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT3</accession>
    <name>A0A4Q9LTT3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0978p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000978">
        <property type="protein sequence ID" value="TBU11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0978p0020"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35241" checksum="9911FE03068BC3D1" modified="2019-07-31" version="1" fragment="single">MTGKAKEFLEVIGLEINKEKSPTNDTFCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQRKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGIVRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELRRGLHSVELQSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKSHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU9</accession>
    <name>A0A4Q9LTU9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DnaJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1338p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001338">
        <property type="protein sequence ID" value="TBU11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1338p0010"/>
    <dbReference type="OrthoDB" id="2191416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044648">
        <property type="entry name" value="JJJ1_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45495">
        <property type="entry name" value="DNAJ PROTEIN JJJ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45495:SF1">
        <property type="entry name" value="DNAJ PROTEIN JJJ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="51051" checksum="3962118BE0E60A5C" modified="2019-07-31" version="1">MGQRQSKPIIKSSYDILEVDENATREEIRKKYVQLLQKNHPNMNPSGSNEKTVEIIRAYKEIMKIIEQKEAEPPKMEELEIYTVSYFNTQSKDDFYIKVNKLYSRIYNKGPQFGFENSRNFSGFYDFFKKYKTWNNSQNEDTEFQKKYSYKIREITNIICMLDPRIKKPTKKDTKVVNRKEVNIFIEKEFEDEEYFVEPKIQPTYFLCDFCSKKYKSKNQLLNHFRSKKHLEGVSYHNTEPTKFIDSQISELMKEMENSNLKKSKAKKDKFNFEFTQETKFFSNDDHEEIRSEIYDTESFESSINRNSKHMNKKLEDLKILKNEPKVSNNDIKDSGTEISEMNDESKNIKNEIESKVNEVSKKMKKIVSVKTKVKGKNKEVKILRKIKKSENDHIEQPQFLVCRICNIIFPSRKDLLQHVTSIHNSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX4</accession>
    <name>A0A4Q9LTX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1410p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001410">
        <property type="protein sequence ID" value="TBU11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1410p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="282" mass="32925" checksum="DB456A5490BA0498" modified="2019-07-31" version="1">MSNSFSGKNTNENKYDFHVGETPECIECENDNVLKCLVETSGSHDENLPLTTIQTLRKQMVYINDRERIIEKTLEGYSIIVRRYLKTGLVFVEKRCGDRRSKLTLEIKKSLQTYVDLECTKTQCTFNVGVARCTIDRALREFHYTPKRLKNNYATSFSSLEVDNDDKNFVFLDENGEINESCQRQIILTTIFVMDNARIYHYLGLNDDEEIASYRIKYLPPYSQFLNPIENVSSVWKNKVIRGGARTEPQLRILICRKFNEIKGEHCSSFYRKMLGYLQKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY8</accession>
    <name>A0A4Q9LTY8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1316p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001316">
        <property type="protein sequence ID" value="TBU11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1316p0010"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="81727" checksum="E1081B83E1C4A109" modified="2019-07-31" version="1" fragment="single">DTIEKNIEGCTSFNTELDVSGEKQAFEASASSREPIDIVTFDYSDSFMIRSKYLDELEKTEKYQIKLNIRDITKSEVDSHIFRECMNVLENGWNLDFLGIKKEEFLTLIWLLYDLRCYTESDALFILYKNLLSLLLIYLSNSTLPGELNLFYADFMNHNKYFLPFIFILYDNIYVKYDSKTKELSLIEEKKKMMYTSFEEQDIDEIIIRTTPIVLELINKENSKDKLVLLNFIACSYRIRGIKISNKDMYYTERKDLNHACKIMKENSIIEKMNTSYVQVFTTTEITESDDIISIEFENIVISSSDNDFLIDRKNLESLILIRCNIPDTNFLRQLSSYFSKLRNLYIVGFIFNNKFFRYLHVMKIECLDIPFCKYKGNPAGLNPQKHEKLKELRENYTQINYKILNSIMLCNALEVLHIRGFSSVRFIHFEDCKNWQKTFRSLDLSFCQINSVYMDFFCTDIKAENLCLDQFYKIDCFKKILNQKSLHTSTKKLTLSNNLMSEDIFSYLAAFEVLEYLNLSFLKCNSVNFLNSDYKFKSKLLYLDLSGNGLQKTNFSFINQFDYLSRLDLSDCKLKCEFMSYLTNSFLIASLKVINLSGNILCSSDISRVCLLENLIHLVITLDNKVFSEFLKEYGVLECLSLETIVLINTNVNADIKKFIISQPSLKNVRLRGCMTEPNYLTMNSNVSPDFFKTIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU16</accession>
    <name>A0A4Q9LU16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1301p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001301">
        <property type="protein sequence ID" value="TBU11251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU16"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1301p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="231" mass="27795" checksum="F27690EDF761E12C" modified="2019-07-31" version="1" fragment="single">MNRIPDNDIILENKIYKHSLKQIVNLLNKISETKKPSIKETKTEETDKTTNKPTNISISRSISFLKEITGTQNDSSIPFKRKLHESKKETLKALNDHKIEENQAKKLKIKKEKNSKENSKNNKNIKNIRESKEEYNKEGKENSKIDKNIRENRENRDDYSRERNDNLKNNRDFKNKRESKDDYSRERNDILKNNRDFKNKRESKDDYSRERNDNLKNNRDFKNKRESKDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU25</accession>
    <name>A0A4Q9LU25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0880p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000880">
        <property type="protein sequence ID" value="TBU12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0880p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020453620" evidence="1">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="434" mass="51497" checksum="E0ECBA59D02D67C0" modified="2019-07-31" version="1">MLVYFLFVSTIYCAKSVLTDAGVDYKQKKACLEHGTLKFEKLVYKIIERLSPGYSSDFFKDLYCMNVAKGIESEKLHALFDLLTNIKIKNIHIFYLSIIWQDKDEDNTEDQIEKLLRIINEHICLQNQKTVKKVMNHRTAPFVQTKDKSMKFIYRNIEPKGNMKDNFEFFEKIFSNSLQKNFCDENVESHKYFTILVKDNFTEIDFISFKGILLQYLKEFTLKNNEIIFSFDDNTLRTLNDICFEFRLKFPEIEHIYRFSYEKKIKSRSYNFTRMFIKSKGYFISEELNIISIKINASEKERTKDCFSEKKCILYFKTTPSQRYDYKNINPIKKDITFDVNDLFSLQCLNKGNFFEEKSKTGEINFKKGFYVLDVSFSNKRAKMIAFKYIFIFNIVGFVSHGYRDKITTIGRINDVLIIIQEIHMKLAKGFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE2</accession>
    <name>A0A4Q9LUE2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1019p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001019">
        <property type="protein sequence ID" value="TBU11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1019p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF10">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="79066" checksum="AFC6E9D229423F03" modified="2019-07-31" version="1" fragment="single">IRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLGNELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNIEVYIQSIVLKMTVETISFDRRRGLESGLNAEESWERASMGNNTPLKEEKREEYGGTTLEEPTNNINEESDLEEETVVVKEESNTMDDATPPKQAKRLTKYGKTWETSHPLSKEVKNNTFKAFCTICNEELSCAHGGISDLKHHASSASHINIIKTKASSALSKFINKPNDAVLEFKISVSFGEITCVYHTVKHGLSYNSMDCGHKLLPTVCSDSKIAQKFSYCFELTKESINEVLKSLKENDSFFSIATDAKNKKNRKMFPYVFVILTYILELRIGFWTFLIKCLPFLQKTNVNFGCNHSIYTKFKELNNSINKLKVDVECLRLNKHVVTRFLTLGPAIQRILKLWPALKSHFQDEDNECPTSLQNIFISEEEENKMLAYFAFLHNVKFVLENTMKKLESHSLTVVEMHVQMNTLFKKIEQRMNDNLSGRQTKKILDLLKQSNVDLAESMKNDFLSFYSNFITYLRKMYDFSAHNMLSNGELLNIHVDEYDFNAIQKWKTVFKPFSKTDVQNIFQIVEFIMSIPSSNCYVERFFSQMSIKWSDVRNRCLFEIIRDELMIMFNFKLDCKSFYQYLKTNKNFLKKLQLSSKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE5</accession>
    <name>A0A4Q9LUE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0868p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000868">
        <property type="protein sequence ID" value="TBU12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0868p0020"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="224" mass="26419" checksum="C3EC4B5556D134D6" modified="2019-07-31" version="1">MSTMKIEYEIEDLEDVMNYENCIVVSNHIGAFDFLLINEVARKKKMLKNVKFIIKKSMKWVPIFGWGLICLNFVFVERNFLKDKLNILKWTKNVKKNKIPFWIVIYPEGSRFTDAVKNHSDKFCIENGIEPLKNVIYPKTKGFNLICNELRNYVDTIIDLTVEYSESGNKNVPTLSTVLFGRTNGTVRIKSKVCKIKDIENYDQFIVERFRRKDLIISKWKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM3</accession>
    <name>A0A4Q9LUM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1286p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001286">
        <property type="protein sequence ID" value="TBU11280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1286p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="463" mass="55196" checksum="A501972068957164" modified="2019-07-31" version="1" fragment="single">FFCENCERKAFNLPRHREDGIIIVFDVDIWYELRRENHIFTYRNENSIAFEVFNNFLYLKESEDKHENGIIGSDFELAYFLKLTENIAEFSFKLDTYYLKCILILLKCFEVVENRSLLEFLQSLFFYGLVVQKESLSRKDRFDLENAFHSDIFKKLNFSIQKSLCYTFLNMFMITFVFNDGNLIILEKANELYDILLFDKHIPYKNLLKYEKIKIRKLEISPEVYNWIFQKTYIKVIYIENYTPNDEPLTINNFTNNISLTKLVLINVRICLSFVNEIFKLQNLTKLSLESCILESFEVYLPFTLFTKNLISLSLKYTDLVLYKYADIPSQFTSLRHLNISRGNLPPSYISKLSLLCDSSLKVLHCKSYTLDKKDLLRISKLEFYNSLYALNLYSTILCNEDIIFLKKIKNLRFLSLRLYDLDIKILKSCLLSLSVEKLYCDINYIEYIDLKEYLKEKDILAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM8</accession>
    <name>A0A4Q9LUM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0787p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000787">
        <property type="protein sequence ID" value="TBU12363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0787p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="602" mass="70940" checksum="C74EAC5C0632089F" modified="2019-07-31" version="1">MLCRQNQKHSKCHLYILGKLIKYIRKENFYPMNFFYIFFIHVLTTDRGYSGLLQDPTVVDNSYIEFCKADYATPFSIKNYIVGGKIKNISENRLKEINLVIDSYMYYIREYIIEPSIHEFLEKFTTLVCIIIYGSDTETLVKFRVELLTNIIAFGRFVEMYRKESELGLIVKPLIKSFLINEFGSLANTSKIYNKDMEEMSVIFNSVYEDIMNSNIKDFSEEFIELKNAEIDFYRIIETISNVQKNFNDASFERLFSFWLSVKYAYLAEKLSKMNDKASNNKKFSFFLDNKFLNKISERDTWWQDSFYTKITPDLFQNMIKYIASPVIKKILTDEDKFQDILNFERNKNSSETVPPVDENFPTEFTNLFIEKSKSNQLIVIYNLLISVSKEEYHKCISAVICLKVLCFEKALSDNEVILRIIIEFLFFVDILNTEFEKQKYTEQMNFLSEEFKGVFDLSKLLSDLENQENDNELFLIETVAPKILNLIEMLVLINTFGDDVFLDKLDKCIIKVLNKTNNEQFELKSILDKQKEYVSFVFEEESKRYISSKSQNKQQENKNNKSKEENTSNFASKKNMFIILSILLLLAICGLCGYLLLRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE9</accession>
    <name>A0A4Q9LVE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1045p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001045">
        <property type="protein sequence ID" value="TBU11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1045p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="397" mass="46346" checksum="8536DB2DA4984310" modified="2019-07-31" version="1" fragment="single">LKDICFQSVRITKNYWKSILDLKNLQSIVFKKFTVIESAKEFYIGMKYCKCTDSLTRFEIHDITGENLVFAFDFVFLLKKIRILKFIVINGYVNLFLPRTYNMKMNDSLEEIKFFGLFINTFCVRYILRNAGLKSLVLDDCRFEGCSFKDLGSTSLVTRLQVLKLKYVSISVEDLKFILELKNLVDLEITECRFCLLKSSKLNSERCFLREKPHSTKDTEKNFSLAIDSFAKLEKLKIYNSGIDLMKSNFSGYSTICSKIKKLTISNTDLYLKDMQIISNMRSLVSINISGCVLNNCCISNMKNPSFLKNLLSLNVTYIPLKKPDISFIISLKKIAKLKLSIIYLDISNIWLFNSNNFPSLTLLVLVYQNEDHIKQYVFLKEYFSPILEFRYHRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF5</accession>
    <name>A0A4Q9LVF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1110p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001110">
        <property type="protein sequence ID" value="TBU11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1110p0010"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9832" checksum="4019159192EFBB83" modified="2019-07-31" version="1" fragment="single">MHNDEEKKKLYSQFKATLCTDDSLIKTRESNYIWRIWGLSDFNHERFLSVTNLSTDYLNLLDRCDLIFGYSNICGANKGFRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL7</accession>
    <name>A0A4Q9LVL7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1016p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001016">
        <property type="protein sequence ID" value="TBU11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1016p0010"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="249"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="413" mass="47774" checksum="9E8EECA4EB325B91" modified="2019-07-31" version="1">MGRNPSDEELIEYDETLTKEPKKTERPVTTHTSFFKDFLLIDPLNKVLASINFEHPSEVQQQCIPRAILGADILCQAKSGSGKTAVFILSTLQQIQPIPKETSAVVIVHTHELAQQVYGEFLRFLKFFENVTVDCFHGGSDFRDDRLRLEIGQPNIFVGTPGRTLDLLTRRIVHFRHVKHFIIDEVDKCLEKDTMRFVIQRIFVKTPRNKQVMMFTATLNEDKKKLCLLFLNQPHEVYVGDESKLTLHGLKQLYLNVSEENKKQKLEQILDTRNYSQLVIFVEDKIKARNLNTYLKERGFPSIDIHSDIITEERKKRFLEFKSMKHRILITTDLMSRGIDIQDINIVINYDMPDCPETYLHRVGRAGRFETKGEAISFVSDSTDSVILNQVQSRFEVSISDYEVTGDKDMLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX6</accession>
    <name>A0A4Q9LVX6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0600p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000600">
        <property type="protein sequence ID" value="TBU12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0600p0010"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="111"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="247" mass="29360" checksum="7316A90C33256DCB" modified="2019-07-31" version="1" fragment="single">MGWREVKQDAIGFIAYAIYPVIIIYSYFVVVGIFCLEDKRFENAYIIMTFIIYHFLALYTGIFYMRLLSNDEVSTLSLFPHMRRSESENIIDDINPFFIQEISKKRLRDIQTCNICKTYKPPRAHHCKKCKKCFLKMDHHCYLVDSCIAFHNYKFFYLFLVFNSIFMLYVILTLVFPIFMDDYTSSTTNYIIIVLLFSIGWIITMFFLVLHTKLISFNETTIEYETLEEYLAKEPFNPGVFQEGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW01</accession>
    <name>A0A4Q9LW01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0624p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000624">
        <property type="protein sequence ID" value="TBU12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0624p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="611" mass="71997" checksum="718CB29362F0A970" modified="2019-07-31" version="1">MITAFILLLKKSLSSNSENITENLSEYASVMNEESHDSQLLSSVFFLKDEEIGKQDDFEVNFEDHIFDYTDIASIYEDKMLSDPYSHMNFDQANVPKDGSQVVKETANNLGKKYLISDNSKAKIDKIDTTEKTVLNIPKREEIKDGPLQHGTIGKFCSVVNHNCSISCQECSYEISKETHDQKDEEIHEYNDYTMVKSSSKRKGPKTRNFTLGINKSVKKFFRINLSHQNMKSNIKNFEHQAAVDFLNNLHREIKIIHQDILPDNSKSEDKVWFEKKFKKKINSIKINGIKTYEDWVSNLKFSKKIVSYEKTFMENSSIEEKNSFLVRFKLKKFEEYISEISKYYILSEIPFFIYSYNKGSIHIKEGYVFYVSFMLKLLEVCYSNNERFDRLNDQFCFKYNNNIILFRLIFYNMLSGIKDFDCKKNFYIVISSLIYFNDIGGIKKTRYKKKIYCIQLNILLHSVFLQSSIDKDVNKAIEFCKSTVLNAIESSNSYEKDCFKKFFLHLRDIDLIREYTKIYSLMKNQALCEKVNLVFDEDSENLLIKYSKEGTYANENREYIKDLFTLETLITCLNSKLVYCRYKLRDNFNFCGKKDFWKTLNAELQKSLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW73</accession>
    <name>A0A4Q9LW73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1492p0010</name>
        <name evidence="7" type="ORF">CWI38_0967p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001492">
        <property type="protein sequence ID" value="TBT99036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000967">
        <property type="protein sequence ID" value="TBU11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW73"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1492p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0967p0030"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT99036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="144" mass="16501" checksum="7F50BCC46861A522" modified="2019-07-31" version="1">MGRMHGRGKGISKSTIPYNKIKPSWVTLSPEEIIQEILFLARKGNPPSKIGNILRDVHGIGQVSFITQTKILMLLRMHGLAPSIPEDLNSLLSKCYTMRSHLSNFKQDKSAKYRLILTESKLYRLARYYKRNMALPANWKPNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW93</accession>
    <name>A0A4Q9LW93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0898p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000898">
        <property type="protein sequence ID" value="TBU12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW93"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0898p0030"/>
    <dbReference type="OrthoDB" id="2190565at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="39258" checksum="ACC820EDEDEA2C16" modified="2019-07-31" version="1">MRVSILTWNINAKKSAFSDLKSIIENEMNADILFIGLQEVYFTFMSTSDLYNRVKDCVGSYNIIGFERLFGIVSFVLSKNNLQSESFRMGLGFLNNGYKGFTSHYIQFSDTNEKNNILFVNTHLTAHEKNLDSRMKQVSECFKAISSAYNIKEIDTIILSGDMNFRVSGIDRQKVYDLIIEKNYEEILKNDQFNNFSEKYPRFKEGNINFQPSYKYIAGTDDFEVKKYRVPSYCDRILCNSKYKHNFTEYKSLENIRTSDHKPVLLRMEFEPIILDNSELLSDIADKNYIYKLYASEMFNFFHENIFLIGIMTGIVASGSYLHFKNKIKRFFEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL7</accession>
    <name>A0A4Q9LWL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0926p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000926">
        <property type="protein sequence ID" value="TBU12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0926p0050"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15993" checksum="AA93F0025C5C097B" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENMKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ1</accession>
    <name>A0A4Q9LWQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0507p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000507">
        <property type="protein sequence ID" value="TBU13189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0507p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="29334" checksum="8FEE070E0B2EC355" modified="2019-07-31" version="1">MMSILIYLIVEKYLCSTSNKSVLGIDNISEKNNCIELLIEKFKCEIKNSFQISENDSLSKIAYTFTNFISMKILKEQRFKKIAHTIKISHLKNKSFVEKSDDFFIPNYNTDDIKITKTVVMKYNKALIFFVCISLRKSYFESIKNIYNNFLESIKENAHLYSDLIFQNIPNVEHIIEAIDKMESIYKSSLGTICSTMSSILNGKIEKQQIQELNDIILKLDGEKQIYLKNKQIFSNLWRVFNEKNRSNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX01</accession>
    <name>A0A4Q9LX01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit of U2 snRNP spliceosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0473p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000473">
        <property type="protein sequence ID" value="TBU13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX01"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0473p0020"/>
    <dbReference type="OrthoDB" id="2196406at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="917" mass="108894" checksum="E64DA604E813137A" modified="2019-07-31" version="1">MKNGKSEFLIKVKKKDTKSEWEDEVEEVGVVEKISQTPRTTTQTKRMMWDQTPVGRIKNGNFDTICSYGLSSKWDLKPNSDKFFIKENVEFNLKEIIKIVPRDIFKVLEPPLWYLDNKKEENFITDLELPCYKAEDYQLFNQLILNIGSESFEIEILKNLICLKNGEKKEVKNAKKKLLKIYGKNKFLYEKITSILISSLLNDIEKLKYLEFLKILIEYSDECFFLKDFMIIMATFILGKYFRLHKICIEIFYLIFTKHDHNFVLLLFEDEIKCKNEIYTKNISFIIYLMINFYDLKSLTLFFKSLNKSKYSKANELLAEIFVQYTLKHRNIDFKFLVKVILKLLKKENEFLKVKGCEILNLAIYKSTDSDIFLDIIDYIFRECHNVSTKVFVNYLNVLATFREKFEIENFKIEIFFRINKLIYKRFYFEKCLEIYRKICLIIEKEDSFYFLQKHFKLILTTKKIKNLQLLLEKVLKNPKNINIVFEMYRNESEVLRNLISKVIVKIDDLYIVDVQMNDYFDCLNFSLSKNDIFTIKNLEILIKKSNYQYVWIKKFFEIFISEFIQRDYQIKIYGTQKVSKIIAFLEKDDILLLYSLLIENLKDENSEIFLESILNCLLKICQRKIQNTKELVLNLTILIKNRNKNVQENILKILKFLCKEESNECENIHSKEWLRIVYGIIDILDSPSKNIRVLASECIGYISINIGPQDILNILMNSLKTLDRNQRNTTCLAISILADYCGLFTVLPTLLTDYSIPESIIQHGILKSISMIFARVNIKGRDYIPCLINIIEDSLSEKDIVHRQLGMICVKSIVLSCKSPNINQDLLIHLFNYVFPNIFETSVYLEDIFFQCMEVFCLKMDPLILIQYLVQGLFHPAKRVRNKYFKILEMVEKYRPDSFITAFSYDEDAFLNFEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX02</accession>
    <name>A0A4Q9LX02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrillarin-like nucleolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0606p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000606">
        <property type="protein sequence ID" value="TBU12847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX02"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0606p0030"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047099">
        <property type="entry name" value="Nop5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="280"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="43939" checksum="9D21BFE244D43240" modified="2019-07-31" version="1" fragment="single">MDLILFENSMGFALLKINEDSNLFLHSFYPLSPAQSLENQHLLSQGQVSSELLSFLSLHKVKSLICDKSLHSALSKEKISVKSNNDIMRNIRLNQIKLLKEKQTDINQSILSLSHKYSRDKIEYDTKKEDNFVIQSYLVLEELDKDISKYIIRLKELTSNFFPELSNICDNNNDYCKILNIFIEFYINKEEELKSSSVNLNELNFNKKSIYYEELKNELLKNIKDNLFVENILNSYMISVGSVLFIYDLKNISRINKIIIEKQKTAENLNNYLIEKLTQIAPNLLALLGNKLSAKLIATAGSLLNLAKCPSSTLQVLGAEKALFRALKAKSSTPKYGFIYQAPGVSQVNSDDKGKLCRFIASKCSIASRIDYFSEEKTNEYGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX28</accession>
    <name>A0A4Q9LX28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0469p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000469">
        <property type="protein sequence ID" value="TBU13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0469p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12956" checksum="FA9DAB4875CB35F6" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNKNEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE1</accession>
    <name>A0A4Q9LXE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0562p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000562">
        <property type="protein sequence ID" value="TBU12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0562p0010"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="357" mass="41953" checksum="1C47368EAC42B895" modified="2019-07-31" version="1">MNHFYFIFLLYKIFTTNRNYSVGFIYEISQNRDFFVKKPINEYSKKYLLNEKCVYETLNHPYILGMRSSNFEMNEVSELQFEIYDFDLKVGIDCKCFNDFEKIAILRMLLDVVNYLHANKLVHNNLVLENILIKGKQLKLSNFAFSAFTDQTKERIYENLDTIGFYHNEIVFNSKPEISDDIRNLGCIIEELFQLNNYTSEEKEKSFTLKEAQKLVNKMKNCDLSEMISVEMALKSKIFRFHYGFIRCFCGFPDKKIITHTGIYEKYGNSLSRIFLNQIIFINCDCICSSSTENKTQKSNTILKQLMSGLSRGCRCCRAEPKNIVVTINGISNCLLDLIYDDLSIVEETYNKFFLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK9</accession>
    <name>A0A4Q9LXK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MutS domain V-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0541p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000541">
        <property type="protein sequence ID" value="TBU13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0541p0030"/>
    <dbReference type="OrthoDB" id="2195817at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="169"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="536"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="753" mass="87415" checksum="C32609460D6DE9C7" modified="2019-07-31" version="1">MLMNCDKTDNQTKTACIAISRSKFPLVGLSIHESTTNKIEIFEFTDNWSFHILIQRLKIDSVNKIIISENQNVLENILHKEVQESDIIILPRNNFEEDIDSLILENLKNNFNIESLRDKHFTLSSLSALYKFLDKNIYSCFLEYILLDQFMFISQKTIEDLEIFKSKDNKGPTLYGLLKNTKTKMGEKLLKYNLAQPLLDTNEITNRHDLIIFFSENQIVFHTLEKYFKSLVDIDQIINFLYKERSDSNYEYDVGCCVKLNSLFNIIEGIKSFYQKYESKEILTKNLILKDFFNIIFRPEISEIINSINKIFDRTALYSHNTQENISSCIKIIRNGVDTKLDISRQIYSENLNDLYEILSDYESKYSLSINLVFDSAKGYLFKIKSDEFKIIEDNFYKDIYKNQNDDIIREDPFSIQNASTEFILISRKKGFILFTSVEVQKINLRIKDSYLQVMEISSKIFEFSKKKIFSFLEIFHILGNIIGLVDLVISFYIFTKKYKCCIPEFGDSLIVTESHHPFFTAKNSILNSFYCCPDLNFNIITGTNMSGKTTYVKHIALICIMGQIGCPIIGKYASLKPFKNILTRLNSEDNMEMNLSSFAVELLDIKNILDFSDSNSLIIIDELGRSTSYLDSISFSVVVSKYLVFKKSFTYFITHFNEIILCLKKYQNVNVLKNCNFKVTSGINKIINGIEIASKFLNPKIINDSLEIKRNISCFNSGTVDTFQNSEIQLALQINKTKNKEKALEEIFKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT8</accession>
    <name>A0A4Q9LXT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0379p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0010"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF36">
        <property type="entry name" value="TYPE A VON WILLEBRAND FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="4">
        <location>
            <begin position="429"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="3">
        <location>
            <begin position="526"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="89132" checksum="ACDC4B166FCD90C4" modified="2019-07-31" version="1">MNSPIKMHKRNNIIRDGKSRVVKDFPKGYATSQQTKTEKIQNELPKPEVNAPSLPSEVEKDQKIFFSFDTSSYPPPLSTTDFFVTETKNTDPNLLRSSFYVIPAEPSIFQSINLPLTTVLQPFNSKALINEIENIKSVRCMECLAYVNIFTKIDDLGKYFKCNICNASVELKGIITKEDPILRFSTLDYLKKEEEIIYKPNFVDSEYFNYKFYKRPIFIFCIELTSSSISTGLFDSSLDSLESVLLNRDFSILYESIAIFIFGREIKNFCFENEEVAEYVITDDINTPFVSTSLLISLDSEFYDFKITKLFEVLRNLKSKDSISCLKNMLNVSCMLSCMTPGAITLIYMTHLGQIGDFSYLSNNITEMTSKFLNSSNSLFISSLEKTTDNPLIRLCFNCNGNYNFYKNLFELRKLLVKDVNEICLKQRGFNISIETRTSDSIRKSSVYANTSSETTLSVFISQMSDSDTVAFSFYIDESVKENTILYLQITVNFIDNFGIQKVRVFNHSFISSYKIATLYNNLCFDTIFCSFVKFLMNDTENLKKNLENIKNMLIKSLQFYRTSCSSQATSTQLVLPESIKLLPVLFQSLEKHKFIANEISYSDFRKIINFSVQKNLRFFYPRLFSLTDYFVEENLKKVNCLRLSSQNINSNEIYILENSLKIYIYVGRQVEKELIISLKIENLEDLNFYNFCTENEENENISEEAFVLKNMIKEIKECYDKEMEVVVIKQGNGQIETEFLENMVEDKLNNVGCYGDYLCDLHFKIQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX2</accession>
    <name>A0A4Q9LXX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0514p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000514">
        <property type="protein sequence ID" value="TBU13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0514p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="297" mass="35403" checksum="4C820E23FD86026A" modified="2019-07-31" version="1">MYPTDDTISTEADKNIDEEKEIILPTSVSQGGKKNNQKQQLNQKHIHKISKTTNQISYYSFNNFVGEFFKELSEKKYEEIFFESVIDEDIAFNKLFEESYTCEVKREISLKNRLFSAFITDDSKNDTIYTENDFLKSLNLDFTNTDDLDNLIVELFIQNKIPIYDETEFALNGNEIAKLIVNLKKQVIINNKRKKIFKQILQKRMLFMSFLQALKIIDSKLQKLYLKRNKAKVKSRSNEEYEEIKTLLDIRKHFFELFQDELNYENILFTIDNLFTDHNEQNIKLKDYNPDNYFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ9</accession>
    <name>A0A4Q9LXZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0361p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000361">
        <property type="protein sequence ID" value="TBU13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0361p0020"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="575" mass="65704" checksum="7D1A6CF05FDA09D4" modified="2019-07-31" version="1">MKNVETTTHNLYFHDNASIFSIDVHHKENLIATCGSDKAIRIWKMEINSKLKQNEVTVDAQCRASNEISIKPELDNFIEEEINSTPSDEKEESSNEISIKPELDNFIEEEINSTPSDEKEESSNEISIKPELDNFIEEEINSTPSDEKEESSNEISIKPELDNFIEEEINSTPSDEKEESSNEISIKPESDNFIEEDNKNSPPNEEIKQEPNSSMNFLQSTGFKMKYFTAANSSLRFVYSKTLLNHSRSVNCVRFSICGKYLASCSDGGEIVVYSIYDNETVIVRGIDGDDAYDICWGKDYFFVGFGSGFVRIYKVKQNIVFTSQNVNLIFEKTEDSDKSPTTDSKTNEDENKKNIKNNKRVKILQENPYSFSVTETFSQKIHSDLIQGISYNFEFSLFTTFSRDRSCKTFFFNEKKIKMVEKIEGIFCGERSKSFFRRGCYSSDGKFLYLCSGLVNSSVFSNESKNIPTNPTLSHIANLDGKKTTHCIFVLHYPFKYKCLYAILGPFDSAVTKIVYLEEKLFVVTKKSIYVFENQKLLFCVANIGFLPVTDGVFWNNYFIISSLDGFLSSIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY57</accession>
    <name>A0A4Q9LY57_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0362p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000362">
        <property type="protein sequence ID" value="TBU13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0362p0010"/>
    <dbReference type="OrthoDB" id="2426083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42349" checksum="4DAA6D20BF96AE4B" modified="2019-07-31" version="1">MAGPEPRGESRRLELLGDLNSKVGKERAYTSIIGKESLHRDRSENGPKVRELFGKNIQKNMNSYEESGKSKNKEGIEETWERLNKEHKGRQSWFDEEYKIALHAKPGTKYIVTETNAPEKIYLYKKIEYETRKAGLRINRIKKKMHDDQEEAGKYSAFLSASFKNLRMLLTKDNDNSDISRLFECIFNIRGNTLPSFSYSDSSVSNDLDLLFWRAKKVVRMSRNNWYVIFRLYNEKLCHYLIAMCKKNSTHEAENKKRQKEMQRGPCLLTDNKLYKHQRDVVCTIPKLSENKKENTVLLNVFINKEYGNNCKDPCFAVNKVYDLIDNASVRPLYKTVFCYTQDIHLFCGNEGVCLAATLRTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY71</accession>
    <name>A0A4Q9LY71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0668p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000668">
        <property type="protein sequence ID" value="TBU12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0668p0040"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="606" mass="70823" checksum="6949DD5D1A557836" modified="2019-07-31" version="1">MAFRFNVTDNSEECEESSTSTIFYECRSNSEDSLSSDKEEVYKDVADFDEAVKRKLENLKKAKSRKKIIEENKNNPEKCNNPNKTVRKKKEQPINMSDIFLPRDQLKNRIADSKYEAEAKQLVLETKNKKEPPIDIKGFKPLENILGENPTENIDSICKSIDLANKNDRSRIINRIALYFIEVSSTQPIKDKIIRIETRNEKLEFNLANDAKIPFIIKKSLYQEIHYKIFRKGYFTKTRIFEFLGITVLTEFQVSDINFKIYLDSEMEFNGIFKNEILTPVEYTKLLLARYKKPKGFFGKLLNFISINGLFWSKKGDIFVKDLKTEEIHQEKVPKTLKLYFMFFFSERLSNMAIYRYFLKRMTLLSAKRFDSEKSRSLIIKFVKFYDINLNEIKLDIRKFKNFNEFFSRELKSNARWIEDMDGISSPADSRIVAFKYIKDVGHFWIKGKKFSVETFLNKRKVKIESMLVCRLAPQDYHRFHSPCDGRIEDISYNCGQYLTVHPESVKRCDALTENLRVVIVIKTKKRGYVYCVAVGATLVGSITLSVEIGQKVRHLDELGYFKFGGSTVCLLFSRPVLFHKNVLNNTYIGIETVVKVGNCIGKYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY79</accession>
    <name>A0A4Q9LY79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0664p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000664">
        <property type="protein sequence ID" value="TBU12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0664p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="28499" checksum="C9B8D2CC8AC4C430" modified="2019-07-31" version="1">MSWDGIVTKYYKSHLKRLEIPMNVEAYMQSIVLKKTVETISFDRRRGLELGINAEESWERASMGVIMRAEMHEEPTPPLKEAKREKDKAKNFKPKNKAPIISQGATTLEKPTNNINKESDLEEETKVAKEISIGNTNKQAEKCTESLINNTLLTIKMIHLTQVAYMENILAKILKKREKVYEIAKPFLLNILRGFLSNQIVKVGELVDDCHAKVWESSLADSAGKAKIGYTCRYDIVYPSEPRANLRDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC8</accession>
    <name>A0A4Q9LYC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0639p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000639">
        <property type="protein sequence ID" value="TBU12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LYC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0639p0020"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="18"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="164"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="13">
        <location>
            <begin position="1401"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="14">
        <location>
            <begin position="1698"/>
            <end position="1951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1951" mass="225810" checksum="1E7894456B2C69BD" modified="2019-07-31" version="1">MKKKCFTTFLEEYGCSKSIRKLLIANRGLAATKFISSMEEFSYKKFGKQIFYFYGIVIKEDLESNYLYIEKLKNYKLVESGPAHLNYCNIPLIVETAKFFEVDGVWPGWGYSSENPELAKLLQENKLVFLGPSEISMYLLGDKFISLLLCMNLNIPVIPSLVSEKVIEEFGIVFNDTNVIDRERINKLMSDMPGSYINEIDPFVKTYGLPIVFKVSSLGGGKGIGVVRETNELNLVYEKIKKEANNTFIFASKLIENVKHIEIQAAGDCYGNIKIFGSRDCTLQRRNQKLVEECPAMISRGIYKKMKNDAKKLLKKANYVGLATVEFLYDIEKSTYYFLEVNSRIQVEHPVTEILYQINLPVTQWMIASGIKLKRIIKLFNVKKRKIHALAVRITAEDPKKNLEPVTGKISLHFQNNQNNWGYFSVVSGKIHEFSDSQFGHIFSKGKTRTEAVRNMIFALKSLKVENILTPKDFLISVLDSELFLNYRHNTEFINYFLQKNYLNVLGEEDLNFIYFPVVYCLDILKILDSDKNVRNNLIFDFIEKHQKSINVEYLYNTIVYNIELFFISTNSALIKLNNTFKVISYEILSKNLILLKTGKTKLIYLEKEDNLLYNMKIDGCIHKFVLDFNSNNVRSKTAGKIVRFLKNDGQAILKDEKYVEIEIMKMNIFLEAPCSGIIKFTKPCNSYVKENEIIATIQKENKENYVYSTYKFLENVGNELDLKNILFGYYFPPKLKDLPNDVTEKLRYIFLFNKNFKKISFDLIEYILASLISDIEFSFESLNLNEKNNHLSNIGTKDLLISVDEIIMKLNSKNSTLFNLFSKFKRTITHIKFLNLCLLTKMHNDSDNRLNNCCFPKDVLLFSINIVEDNVKDIIIKKYLGIVFGEAIKFSKLNRKSLNINKIDIQKEKKLSEEKASHQDLLIKNQNIEFKSKRHFGIFILEDDISGIEFAQYDYIFLYNIEKTDFLTNINNKNVIKIHTDKKYPFVTYDFKPNDMKVHLNQKNISNTNVGKNTAKDFPMQNSQKLHSKYGLKSNNNNKISSQIQNSSEKTHFGDIDINENNEFHDFYKNLAYTSILSKYENSLIDPLLFKYLEIERFRGYESVLIHKCLFRNMFVFLSKANNKRRLFVRFIIDAYSGNTISDMNNLIHAIFQILSTIKILTFQHKTTNNHLLVVVKGNFSFSPASTYDIIDDCIFFFKDKFLEVNVTECEIKIKLLDKSRNDKITLDNAEEDAKRKRVDFFVILLSHLKGYLEKKIYKNDQLVLYQINSHLIHNTLKNSLITNKNNGNIFFREQKYDNCFHSLEDIQDKREIAIKNSTVYYKDLIELFECNFVSCNFSYEIQQLFLHSKNFDAFGINLEKNQESKDLERKNNSYKLNNDVYFIDNSEKESICNGIVGYKISFNGNAFILIANDISFKNGSFSIIEDVFFYLLTLDAMDSCIPRIYISCTSGARIGVYEKIKEEIEICIDPQTTKDTTENMCLIVRENTDDKMTLEAMENKYKITSIFGNVDSGAENLSFSSLMANITTKAYENIFTLSYVTGLSVGIGAYLVKLGNRIIQKNKSPIILTGNRALNKLLKKEFYTNNNDIGGSDIMQANGVSHLVVIDDYQGIEQIVKWLNYYFNSRIMKEKKDDLINSTLLGEKISNILCDEKNDFCKNGVDAKNHSYRNLEYTSSHPFIENKLCTISYQKTGFDKYCSSNYFMENYNEREVLDFILDQDSFTEYMTNYAPNVIIGRGMIMGKTIGVISSETKNIENEIPGEPDTIRKKKIWTKNVMFPETAKKISDSIMNFGKECLDILLLANWKGFSGGTTDMLNYVLDFGSNIIRILSKLKSKILVYLPPNAELRGGTWVIFDKKLNANIRICAHPKTEVGILEPDGLSAIKFKEEERIKVLERSGMEINVENLNKLGHLFCKLHDSTERLIQNNIIDEFVSVDMLRKYLIENVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF4</accession>
    <name>A0A4Q9LYF4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0309p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000309">
        <property type="protein sequence ID" value="TBU15684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0309p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020657528" description="WH2 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46853" checksum="1F390FF1E33C8037" modified="2019-07-31" version="1">MIFKESGFIHIFYFLLLLFDVLVCTDEEKNKKSISNDTPVVARISGHKKDVSNDTIRFKNNEGSNEHLSIPYKCKKMIEDSKRIVKKKFNNFSEKIKQNFSSKNKKKHKKVSYEIKIEPLLSPTANFYGDNDTETPSSNKPQTPKGILKEPNLEYKNQKKVRFVDDLGTNESEIISSKLTPTYIENSIQNRNTPQENRKSFCPNCKYCKKCIDAAQYDIYSPQDRDKDQHNIHGKQHAPSLPPNQHRGLSSAQNESSNPLIYQEDVYMPIYAQDRRFPRPFSNAPESLGTFQALEKKDYPPNYINQNTIQRPLHPPPPPPPQKQPTQEGSLSSFNQTSKIISPPPPPPPPPPPQQRFAPKHQKQSSSSLTTITQPTDVTSPNKNKIAKDDDALIEELKRRLVKRRKNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE0</accession>
    <name>A0A4Q9LZE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0235p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18876" checksum="C3FFD8A444B8F20F" modified="2019-07-31" version="1">MLEKCVKDIDNHLEENIQLKMNKIKKIFLYFMVGICGIIFGRNLLNGFRSKGIVGIGTRFMEIFMYFMISGGFLNMLSGYYGVSSVFKYYQSSSYQFVDEKYVFICLMFFFSSFFEKCFEPKKHKIMYFVWLLGVMGLFRYVLYIINVKGGSYPFYFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ2</accession>
    <name>A0A4Q9LZJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endochitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0210p0060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0060"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.20.10">
        <property type="entry name" value="Endochitinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF79">
        <property type="entry name" value="CHITINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 19 catalytic" evidence="4">
        <location>
            <begin position="558"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="715" mass="70218" checksum="2A2494CF0B52CB10" modified="2019-07-31" version="1">MHVCDINGNWISVDCPEGSVCEIEETTPKCVKKEDIEEEDTYSEEEYSDDKGRDKKENKKFKFKNFKDRNRSKEDKVVTTTVTRTVDSGAIKTNRMNEGNGKCNGNCKDSNADNKAILETKTIMQTKECKDNNCKDTKNENPNNITTKAIQDCKDNNCKDNIGANSIKEIKDCKDNNCKDNKTEDKANNNANGKNIDQVREKTVTVTSRLIPSNIKFEIIREKGNTTASVQHEKQDNKNKGCGVGGVVCPFIQPTITMPGPINVGNNLQQPVGGGGGGGGGGSGGSGAAGGGIGGSGGNGSKQEGAGSGAAGGGGSGSKGGGGGASGGSPSGGSNGGGGSGSKGGGGGASGGGASGGSAGGGSTGGGSTGGGSGGKSGGSSGGSPSGGSSGGGSGSKSGGSSGSPSGGSNGSPSGGSAGATSGKSSGGSSGGSSSGISSGSSSGISSGSSSGSSSGSSGGSSGSKSTGGSAAGGTPPGGAGGSSSESSSSTKPGGSSSSPNSSGSSSGKSSGGSSSSSSGGDISAQEIMECCSACGFSPPQENCDAVAEAMKGKFESKEEGAMFIAQLIHESSGLAKTEEEACQGGTSCASQYDDGTGGAGKSYHGRGFIQLSWPANYKAASEGIGMGDELLHNPHLVSEDPKIAAQVSVWYWIERVRPAPGVSDNQFGATTKAINGALECTGSNVDKSKKRYEYYLKVAEVLKIENKASEEGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR3</accession>
    <name>A0A4Q9LZR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative PPPDE domain-containing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0197p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000197">
        <property type="protein sequence ID" value="TBU19809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0197p0020"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="16886" checksum="E8C901C85990C4F4" modified="2019-07-31" version="1">MSKHPVILRVYDLSKGQAKILSLPILGIQIEGIWHTSVEVYQREYYFQDGILHVEPVTLKTYDMGITSLPNDVFHEYLEILSEKYNSTTYDLFKNNCNHFSNDATMFLLSKSIPTEILDLPEIVMKSPMYETLINMLRSDFQSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV0</accession>
    <name>A0A4Q9LZV0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA photolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_0090p0040</name>
        <name evidence="15" type="ORF">CWI38_0187p0070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="EMBL" id="PITJ01000090">
        <property type="protein sequence ID" value="TBU04771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0090p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0070"/>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="13">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU04771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="430" mass="51041" checksum="DBF03F61102B353D" modified="2019-07-31" version="1">MENRIIEMIENKNTKNILYLMQRDKRIHDNYSVLYSMELANALSSEYFIGTILDEIKLNERQRTFVIEGLKEIEDECKEYNIYFYLIDKLEEFCAQYNIDCIVTDFSPLKEFDKFYEKLRSLCKKHKYSFYVVDSHNMVPCKLIPTYYKSSKAVKTRLYQKYNQYFKDFDTIKFYTNNDSKRCKEIKNNFPKTTVTNGFKGGYSNGMKEVESFFENRFENYDKYRNKPDYDVLSNLSPWIVSGQISAQKVVWLACHKFSNKNENLDTFLNEIFVWKETAEHFCLYNKDYDNINGALPWAYSTLMDHQEDERNNIYTLEQLEKATTHDDLWNAGQKEMLITGKMHGYVRMYWAKQILKWIQDPKKAVETAVQLNDKYSIDGNSPNGYLGVMWCICGSMDYGFAERPIIGKIRPMNAFKAPKYVAKWANKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H1</accession>
    <name>A0A4Q9M0H1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 9">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0440p0030</name>
        <name evidence="13" type="ORF">CWI38_0128p0090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 9"/>
    <dbReference type="EMBL" id="PITJ01000440">
        <property type="protein sequence ID" value="TBU02636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0H1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0440p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0090"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="58"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU02636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="258" mass="29957" checksum="15BA695E969C5ED4" modified="2019-07-31" version="1">METIKEQDAVILYFSKSYQKQIIIEKNSQTQTHIGVIYHNDLINQPFNISLQLKNTTVRILKPNISLFISTLKRKTQILFEADISLIIYFLNIKKSSSVLECGTGSGALTYSISQQIGEEGVIHTYEVDLNRYEHMLKEIEYFPFKNIKITNCDIITCDKLPNVDCIFLDIPNPWIIIEKCHKALFQTGRICVFIPSFDQAQKVIEKVKLYFNEIKMYENVKREYTPCVIEVENNIKRGYGAVNMQYQHTGYLIFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M9</accession>
    <name>A0A4Q9M0M9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0196p0030</name>
        <name evidence="2" type="ORF">CWI38_0127p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000196">
        <property type="protein sequence ID" value="TBU04013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0M9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0196p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0030"/>
    <dbReference type="OrthoDB" id="410404at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="106" mass="12595" checksum="C5BF0F4482F52EC6" modified="2019-07-31" version="1">MDQFSKITNGELERIKRFMIISRIQYCHCKKRRLGWLGHVERMFTERAAGKIFKAIPEGKRTRGGPRKRWLDNVEEDLMKLDVIQKEVRSKIENNGEVSFKRLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M166</accession>
    <name>A0A4Q9M166_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0185p0030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000185">
        <property type="protein sequence ID" value="TBU19857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M166"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M166"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0185p0030"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="156"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="14">
        <location>
            <begin position="462"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="15">
        <location>
            <begin position="563"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU19857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="76174" checksum="2CE39BF5092B982D" modified="2019-07-31" version="1">MITTINPTLQKNFVTYLITKKYTKNDIECSLNTKEIPLSYIKDIFTDSPTTIFLFSYSFPTKYDDMENFISMSVNFDFKSDEHKDLLFALLHTTPLFTNSIQTRFSLPEYEKTVSLYEKLKVENKEFIEKYSKLKSETFKNKKDQGNLDWEIKGSKVITRFPPEPSGYLHIGHVKAALLNYHFSHINNGTLRVRFDDTNPSKEKQEFEDVILEDLHRLGIKNYILSHSSDYFDQILEFAFLLINKNLAYCDDTDLETMRKQRDEGVKSRNRDMGVNTCTEIFKGIINGKNTEYCLRAKIDYLNLNKALRDPVIYRYSNVLHHRTGSKYNVYPTYDFTCPIVDSLEEVTHTLRTNEYKDRNSQYKWFLENLDLENKPEIFDFSRLNFENTVLSKRKLKFYVENGYVTGWDDPRMPTIRGILRLGLQVDVLKEYILMQGASQKTSTISWDKIWALNKKKIENIAPRFSCVEEKDFVICEIENTKNTTISVPRHRKNNFLGEKKVLFSSQIILSQFDATNLNELEEFTLMNIGNAIVTKKIQEKNLVKKLSLKLNPTGDYKQTKHKINWISKVGSVTVKSIEYGNLIGNMESQDLHTAFNHNSYKETYLLCENSITEVKKGDIFQFERFGFYYCDDNFIFHLVPFTKQKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C3</accession>
    <name>A0A4Q9M1C3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0205p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000205">
        <property type="protein sequence ID" value="TBU19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0205p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020338009" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="7512" checksum="3A82B4AE52DB36BB" modified="2019-07-31" version="1">MKINFALIFSYLFILAICSKKKSKSKGSKPSSPAPPASGASPDASAAPAGAATAEADPAMAAGGSAAPAPPTAGEAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F8</accession>
    <name>A0A4Q9M1F8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0607p0030</name>
        <name evidence="3" type="ORF">CWI38_0065p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000607">
        <property type="protein sequence ID" value="TBU01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0607p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0070"/>
    <dbReference type="OrthoDB" id="10603278at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="178" mass="21076" checksum="9D173EA6408380CE" modified="2019-07-31" version="1">MNSKKCEEYIVADCTKTIFYIEGFTIPCNLFHCIESKRNYQKNKSNKIFPYESSVYQNICKIITDIDRKISMNKKLLRNLNAGTKYKKYENAINECEKIFICEHEKENNYKELHNLLSIHGTLILEMEELKDEPAINLFVCDVCSAICVKREICKHGFHDSYKMLRIKQKELENRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K2</accession>
    <name>A0A4Q9M1K2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0052p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1K2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0010"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="98"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="766" mass="90383" checksum="89E4960A01305B2A" modified="2019-07-31" version="1" fragment="single">MNEIVSDEFFDSKRDIYTDPFIFYRENSNINGNEAFVHQTNTTEMTIISSNITEEVDTFQKISLCIDNQNSSDLLSTNNLSDKLSILLHILTFTSFLQQQILQTQEFLQITFSSIAYLRDIFSDDCFDDFYYDNMKLKILKSNSTNTSTRTFLNWLAGCKDAIQKKYLKSIIIAIYLKNNTEVTETYTFDFNYSKSTPSSSSEVIKTLCKLTQTLKPLPSIKYITIKLFYYDQTPINYEPPGFKPTNDHRFEFETEPLKIEVGDYGKEINTNVKIHTLYDENNTQEIKSINLENNNFLKEKLNENKIEKDFINKTIEKDLNVNNHLSEKQNIKDNKENFLYEKNKNIKENNSYEKNKNIKENNSYEKNKDYKENNSYEKNKNIKENILYEKNKNIGEIEKDNSYEKNKNIKENILYEKNKNIGEIEKDNSYEKNMNIKENNSYEKNKEIKENLNENNQIENNFCKKSFKEFESVNNFKNEKYLNKNLEETSSFLKELNRKENNLSKKNSLDNTPLTTHRDKPVINNNKTTDHILNTPLTTHKDKPVISQENDLQENNLKDTPSHQTTPSHQIKETLKDITKANKEDEIRCICYININDLDMLQCDTCKYWLHTVCCDHKNNNNKNSSNNNNNNSNILYNKRLAIIRRSLSIIYNENVNTLPLLSNRVGISIQYARSLIKRFIDEGFLVKKRNKHSIFYDLLKNENTKNRIKQYFSLNIKKFNFKSSMPLQDIKCGNNRYSDRGVSLYKYILVVKGCYLLCLYKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M7</accession>
    <name>A0A4Q9M1M7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0052p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0070"/>
    <dbReference type="OrthoDB" id="643377at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="759" mass="91177" checksum="FDE4E38C8A50A676" modified="2019-07-31" version="1">MKVSDKNTLIKFTFNVNFIYMCVLFFLIENLKAENNFIFHFYNEEESNLKCDKEHEMPFSKFIKQRYNCLEHKECSNCIKHIITDVDKFSLNFDIKEEEKSEYTIYISKNVLNYDDFRYFLRIIREINDIKENFRIVDCLRLIHTFDIFKFKKDKNFYSFIRILLLSTIYNSKNMYERLDIIKKLNTSSSLFESILCEICNINFFDGKPFLLNVFEHNDDEEITEYLSETISTKSFVNIRLIFLKQIYKHMKYNHFFRNTFKLICKVLGSRKVLLNLENSKEVSFSFSMFKMFLSSEVICFYHWRDIKFLQSIIENCIFKNIKSLIFINCLFSSLNESVFENFTELKSIYLLDCSTTNTVFSHKIYNFMKYIVCGIYDELYNEEKIRKFMTLTNNRYCEPKKINIQSCVPKIKGFYFHDIFDSEKYKIISFDPIVINKSFVTLKTTILNHENFSRAYLILKEAILTRLKFQNTLVKESIRNLYIYNSKLTNEFLFDILLLSNLQVIQITDSTFIFDNYKFKYSEHLLMQELFIVRCESEKNDDIFEFINSMPNLKSLKLTPNSNISLFKYVFKYNMMKLKNLEKFEFEDENKCDKGYSNSLYLGKIIGLEINCPFEQGFLYTLFSNQKVENLKKILIYNCNIGLKDKNSMRNYTRIQSLSFTNIKLFGISFCELFDMQKEYMIQDIYISDVKLSKRDLTFISNLKYLRFLFLSTTDEMFDCNDWFQSFHLNPSKVKIEICFANLDRLNKNRCKEIYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U5</accession>
    <name>A0A4Q9M1U5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0080"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="14433" checksum="212D8A54FB191173" modified="2019-07-31" version="1">MIIRWIEHPSHSLQEILDKEYAEISIRCNRIDIYIFDKRKNNITLIDKPRKYDRLENEMEIIPYLMTWDGIVTKYLKTYVKRLQIPINVETYILFIPLEKRSASLRSISGAEMHKQPKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y5</accession>
    <name>A0A4Q9M1Y5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0026p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1Y5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0040"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000502">
        <property type="entry name" value="Zinc finger protein 710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23717" checksum="2302EC1614C11594" modified="2019-07-31" version="1">MSAIIEKPYICSICCKSFRKPSELLLHTNIHTNTRPFQCNICTKSYFTNKHLKVHLKTHTDSKEHTCQYCNKSFYFRFELTRHLQTHKKSKNIDFSDTESSYSSIKSKTLTEDKASYICNICLKKYVRHEYFLIHIERHKRITFKEYICTFCKKILSNGKSLRSHMNVFHIKGKEFKCKCGKEYGYKRLLESHSKNCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M224</accession>
    <name>A0A4Q9M224_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0029p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000029">
        <property type="protein sequence ID" value="TBU20725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M224"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0029p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="16605" checksum="4405024885A2C294" modified="2019-07-31" version="1">MNKIVQREIDNFKKKLIEFLNENATFEEMVIVHRRLMVAYNLPANKITLKNLKNKLFFKYKELHDKLMEIDKNTEQAEKYLIKEIIETNTEQILGTSEILGRFKSLYPYPVIDMMQCNNSEFDNSEVITEEEEAIKFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M236</accession>
    <name>A0A4Q9M236_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0144p0060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M236"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M236"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0060"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="20266" checksum="4A39AB6E90F4D8F2" modified="2019-07-31" version="1">MKKVGTTIFLLIVSLLIYKYKNIHSIKGVIEDITPFLGYLGVIICFSLNALGTAKGMRSIGKSVSGASILMPRVGAKSIIGTVICEANFIFSLIQTKSLMDILNKCKSVSDEKVTSIVHHIILCAGCIVGISGYASSIATGMNCAAICIMDAKDPTLFANLVAIELISGGIGVLGFVLGFIMKEKAVDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M286</accession>
    <name>A0A4Q9M286_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0045p0130</name>
        <name evidence="3" type="ORF">CWI38_0021p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M286"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M286"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0010"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF95">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="225" mass="26198" checksum="CB023BA6C57B2F7D" modified="2019-07-31" version="1">MNFLRQFFKRRWNRNSDKNQAEEKIMEFQLLYNKAVYMNTILTDELITGIQDSLEQRYQMVESWDLVYSTYENGFSLKTLLTCLSNKKPPYIFVCQDVNKNIFGAFFATKIEIKNSAFGKLNSFLFKFSESHSTESMENKNCTEQISANCESKVSIYRASGENTYFCLCTIDYLAFGCSDGHFGLLFNSDILSGESYPVTTFYNECLSSKQKFFIERLEVWSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M291</accession>
    <name>A0A4Q9M291_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0131p0030</name>
        <name evidence="1" type="ORF">CWI38_0168p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000168">
        <property type="protein sequence ID" value="TBU19937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000131">
        <property type="protein sequence ID" value="TBU20108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M291"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0131p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0168p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="16576" checksum="A05E755ECA6E8605" modified="2019-07-31" version="1">MLVVISIDLNRESKTSMKNRLCKLNKFSTHPKTCITNKTKNTRTNLKDKISIPYIIVFFPNDGTVSGILTKIISNLSKKSLQGEKVEIITSKNNKNENSISKSCSDFHNKERERIFLDPSHLSISGREKHANEDINNIAGFILEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B4</accession>
    <name>A0A4Q9M2B4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0011p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0010"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="28071" checksum="281CF40EBA6089DD" modified="2019-07-31" version="1">MYKGMDNSRENYFDSFHQTPHGELKNAYYNPFVIKHRKRTSKVQLRVLEKTFETNIRPDAALRKTLGAQLGMTPRAVQVWFQNRRAKIKRLNQIKKGQNISDSTTNNENIDTLRHKPENEILNEEKERNFNKMDCYYDYRDTRYNPNNMFTPVTPDEVQYSYYSDSYPESPLYDRNFTKQYNNNRMNHLNNYLELPNTENLDTAWMDADKNREYPGHHYFGNNMPFDPRNFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F2</accession>
    <name>A0A4Q9M2F2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0012p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000012">
        <property type="protein sequence ID" value="TBU20889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0012p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="53362" checksum="8B197A1301791674" modified="2019-07-31" version="1" fragment="single">MNFIDSVFKFFPDRFFQFSELNCRRNFKPVIYTSIIILTFTLCSCSNRVTFLLKTPFIGEKIEYNINDKSFCFGYKTENHILICPGNHIIVNNCIICTKFDNDASHILLKKYIISYPDDFPLISKFIEQSIEEKDGDDVVITLEYYYFDDFLYILNLLKNPDNIIGSIEVMNIAFILKFLMKFEIKYCKYLNSFLKSLSVYLFLHYMSSDKPSRTDFSIIINGESNTGSIVIFIQKFLNLFYVNFERLNYFFSNKNSYFPDLKKGTMENFFSEKSRIMISPLNIAIFKYFLEEKILYNFLNLLFNAIKVRKLSFNCLTTKLNWNQTKFTNLIPFSCIEIEISMYYLDNSFIKYIYPLLSRFTTKKFKISVTEICLKTFEIIKILHNLQILCISYDSNTQSDRILKNIFQLPSYMPTTHISLTLSDSVLKDLYSFPSLLDNIKLRTFSFHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I4</accession>
    <name>A0A4Q9M2I4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0005p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7975" checksum="1BD07E36588FDF17" modified="2019-07-31" version="1">MILNLKEKILNSIYEIEEELKTSNLEISKILEELENERHTYLMEYEKEKNKRNNKIVNKCEYLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M323</accession>
    <name>A0A4Q9M323_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0074p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000074">
        <property type="protein sequence ID" value="TBU20418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M323"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0074p0060"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="349"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="620" mass="70798" checksum="D6C2B6ED39FD6DF7" modified="2019-07-31" version="1" fragment="single">MGRRKKLDSQNIRNEKIKAVNNSENIAGEILMCDVDEAMLSERLPPPPTFHDTTHQPPSSSCQTSPVCLVDTIPSSSANGMTNLNSDAILEGNRLMVLHSILDSVTVQCKRGLRECTEMRRRIATYKFLSKTKEISKKKIGKLPSELIERKVLDLINRIIGEYADSYVPMMITDVAQIIQGAQLVLSKDLLEKARKQEMLSTSETKSLKKIMREFNLNLSSGTDISEALMHESRKKFRKENRMFELFQGRFYRGLSERVEFVHVVSREEIVSFRSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFLNIINWLPNWKAAGIDGIYNFLIKKLTTLHKYLYDIVKVICLEGTPQADWFYCGLTYLIPKKIPRRGSDYRPITCMSNLYKLTRKCVTKVVQIEVERRGLLAENQFGAVRAYDSIDHAFLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDQLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATFLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M364</accession>
    <name>A0A4Q9M364_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CWI38_0068p0080</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M364"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M364"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0080"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020943653" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="393" mass="45460" checksum="64545E7D2C6DC0DF" modified="2019-07-31" version="1">MFLIFFTIFIIFENIHSYQIDIEIEEEIFEIDKQNVNQLMSIPKNLNSIEFETKKEGIFEIDKQGSNQLISIPKNSDTLNSEKKASNKSFSSIYNTDIKTKNDFNQSFTDLDTLLMQINPLYTKKEIFNFLLMCEQTYQNLPSFPGIKKIFGFDTNGMKVIFFDNYKNYVLAIKGTSLIFDGLNSRNSYKRDKMNDILIYSCCCTKSLFPWINFNCGANNVCNLNTWNDNYIKYSYLNEIEQIINYVKENYKDKEIILTGHSLGGGIASLMAAKHNLKGIIFSSPGEKRCAMNSGIYNPNYDYSNILNIGMCTDTIFKGQCTENNPWCRIAGFDLETECHIGNVICIFDITDNMSLLKHKISYMKKLFVNNVYGKIVDETMCFDCKEWQFLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M375</accession>
    <name>A0A4Q9M375_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0123p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M375"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M375"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0030"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="332" mass="38441" checksum="D335802E208A3F99" modified="2019-07-31" version="1">MEIEHEEVLLKYINVSVENCLQEKTRNEQNKAFQMLKSYLPVKPIKMTQITAVFLYSGKKIPLVIKRVVLRKDSPSFEDIVSMRLKHPNVLQTYHTFKTSFINSKDEKQDILWLISEFLTEKVTQKMVSRDEELIKIIITDVLNGLNYMHNQNIAHLDMKIANVMGEQSGTKISYKLIDFGYSRDLNKEPNLHSKNEVVIPHKSYGTFPYKPPEVVFENAHGLKADIWCVGAISWFLSLGKTPFYTEDGDKNIEEYKKFVSGKTKHFFKGEISPELEDFILRAMNPNRHHRPTADQLLKHAFITGETLNDVRSDSYSNDSGYESFSDSYDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M382</accession>
    <name>A0A4Q9M382_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative subunit Rpb4 of RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0582p0040</name>
        <name evidence="6" type="ORF">CWI38_0065p0100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000582">
        <property type="protein sequence ID" value="TBU01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M382"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M382"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0582p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0100"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="123" mass="14392" checksum="FC383261A6468DBA" modified="2019-07-31" version="1">MDNELEAFNSNDTHPVTVSEAKFLLETQMDRFCSETNEHLQNTRKIFLSTYKYLETFSKIKRKTNMDDLRKSLIDYKINEAEIALLGSLIPHTVEDTKNLIPSLDRLSDETLHYVLDRIRKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3M3</accession>
    <name>A0A4Q9M3M3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0129p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3M3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0020"/>
    <dbReference type="OrthoDB" id="2196372at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="519" mass="61279" checksum="088C571647E8F6E6" modified="2019-07-31" version="1">MDYLEISNKTRDLEHKYNSLLINRLNKEKEILKDKITHLKSKNTEITDLLLQTQETLKISKEEIKSLMEVKEKILKNNLNIENTKKEENLRYVLGGEENKKIIKELQKEIENLKNEQIINKRIKEDLDLLKIENTKIILANSSLKDKNTVLENEILSLKNEKNKFFNEIISFKDKIIRMERNIEFYQNENKENESKIKNYEKDISELRNNNKFSVSKETIKKLEILENENNELKTLKNIYKEKDNLLNSLKENLKHKEEIISLQREVLNKYKNTDEYKQNGETVSLQREVLNKYKNTDEYKCKENIEESKEVESESLIFSPLNKFKNLESNYLEKKEFKKSILNPKKPNSKKNKDLEKENKNIFTDEILPKNKTINKFKEGENIRKSEIKKNKEIKKNTVTFKEPENTNKKSILNKNSHLKKTPLNSNTKLPSISSSPFSSRKPKKSVIFHPTKKTSKARLLTQKEEIESDFIVNSKEKSTKQSNENVSLSQPIKLENSSFFANLTFTDSSPVIKKHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3S8</accession>
    <name>A0A4Q9M3S8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_2741p0010</name>
        <name evidence="12" type="ORF">CWI38_0015p0050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="PITJ01002741">
        <property type="protein sequence ID" value="TBT96780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3S8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3S8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2741p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0050"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT96780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="315" mass="36248" checksum="BED86333ED99F0F9" modified="2019-07-31" version="1">MAIGYIKRKKLGEGTYATIYLADEIETEDSSKIYYSPTCTIKPIRKVAIKKIKRSDMIKGLDLSAIREIKSLRKIDSRYVIKILNVFYFSKTLNIVLEYVESNLEIIIKDRSIIIMPEDIKAWSYMILRGLFACHSKFILHRDIKPNNILITVTGIVKLADFGLSRSISTQSMTPQAITRWYRPPELLLGSKLYSFGVDMWSFGCVFAELFLRTPYFPGDDDIKQLDTIFKALGTPSEKDWPSLTLLPNFIKFPIYQRHPLKNLFSAVSDDALDLLSKLLTYDPSKRITCLNALKHPYFINLPRPTIPEKLPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3X5</accession>
    <name>A0A4Q9M3X5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0071p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3X5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="757" mass="90318" checksum="626F4375405D4D99" modified="2019-07-31" version="1">MLPFFSINSSINCLTVQFLEIDEIGDDCFQSCRDNYYFLSTNTCSLEKNGKLESCQTLSPKNYIKNFKIKYPSDTFFSSVFFDERILENQAEVKIYMNKHDFSTSMYLIEILKTEGNIFRQIKPQMVFEILKHLNIFRVKRDEKYELFIKTMVYYSMITDATFARVASSLILNFKDYNNFHVCDLIAFFLKSYFVSKTLIYELFTEYDPMEYTNALYLHKKYKTYDEICFVMFRTCNLHKYLKKAASRCIWRNLIRVFFVDKVHVGFSDKRNMSEVDEMVALLPPHFKKITVAITKETLTILYKLHKCGFLNSKETVKVIFVDSISYEDFMKVISYFRNIEKLTLEFLKVYPDVIHYPNEEFKIAKSIKFIKIRIYRLFLEEIRMESVIQLFTRPNTIFIDLYQDIESLDSKTNLENFLTRNLKNFCIGFNIALQKESYNASYFAKIFDFNLIKRLKMDFISVKSNYLDSYEFLKSFIFLKNLVFKNIKLTNKLFHAILCSPRLISVWFDMFKVSEETNIDEIHTYNESIIYIGFKDLIGSPNENLFYFLNRNISLKFIYFRLHDHQTLKNSEALLNKRINDLHPRNSRKLPQLKSISYENISEISNHTLFSVLYVFSYFLNLENITELKYHVGSLCPDDIQIFSKLKTLRYLELSVQRKYRDLDTLLKILQVNIKNTIFKLDILVDKFEISEIQSILNFKKLKVLEVGIRSKDSNDKKLLKLLFNLNICRIDLYILEKSEYSYMNFSKKTKIYNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M415</accession>
    <name>A0A4Q9M415_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0027p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M415"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16873" checksum="D193D4CA4FCDBEB7" modified="2019-07-31" version="1">MFIKYKKLHFGTIRQKYYHMKLFQIYNSKFPTVVGNIGIFAKIGLWYTGKNSIKTVYKISNFLHKELTNCLKSNNYFSVIIDVTNDKKFRMRIVKPDEYMNIKVKKVQSFDFKPLKIGDAPFTSVEHIIFIAQKIRQIHPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4B8</accession>
    <name>A0A4Q9M4B8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0078p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000078">
        <property type="protein sequence ID" value="TBU20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4B8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0078p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF8">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020701229" description="Leucine rich repeat protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="93020" checksum="44144B0CC1450A99" modified="2019-07-31" version="1">MLNFLPDTLNMLLIVFFCFKKFICSSCVIELIVRGTQEDRIHNKFVFQGEEQRYNLTKNISERINEQKRINCQNDKYPNDSEEIEPINLHLFKIDRYEDFIVRFMVFEDYLLDRNSKKKSLYVANLINKDEITIFLNICLGNIHDLGISISPPTFFRILNFISYLIPESQKYSLNIYSALINIGFLGKYGKDMVSFYHNSDFSIDKRHFIMFLTCFFSPICLCIENDAIIFSNRECSKNIYDFSTCFSIKINSFNTTCSIFYYLMKKLNETQIFAFFWCLRNLNIKKIKFLGLKTYTLKYCDIPQTQEDGLEERILVRKYQRMSLNLASFFINDDFNENIIEVDYADKLDVCKNFNFLYSFKNLEILHIESIQWVLKKVSLIDASYFFLKVRYLLLKNIILTKQVLQEIFRMKIVELAIEKCELLGEITNNICTGQEIGFFTIKKIRFIELKKTSSVIEIFTRIKYLTHFYYKSIDSICLKYSCCQNNEGIFKSLKVLNICCSNTCDCLYSFLNKMRSLESLCFERSTRTGFDLYFDFGNLFKVRNLRYSIKILEISNAKLKEHSISKISKFTKLETLLLNDCEVCIFCFPKKFVFTNLQALKEVNFERSKISYIGIKFLKRCHNLESLILTNCNLTYYHVKKIRSFSKKCLRSLKKLHLFGNNISADMLLFILNLPTLESLEISYDTKSFENLLQNPEIIFSASIDYLGISKAYITKFSLRTLIRRSNITKILFMNCSFADDSTNLLRKDDVDRIESFQVRDCNLSQNLIKEFILLFKEDVYKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4D9</accession>
    <name>A0A4Q9M4D9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0045p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000045">
        <property type="protein sequence ID" value="TBU20612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9M4D9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0045p0060"/>
    <dbReference type="OrthoDB" id="2191645at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK-related kinase FAT" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1746"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2403"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1746"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2413"/>
            <end position="2466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2861" mass="329646" checksum="684D552D9C2D17E5" modified="2019-07-31" version="1">MNYYSTFRLFIYLYSNSSIMSKYFKENVNVFGEIFFVEVMQVGVGGSGGRDGGSVGSRDGGSRDGGNRLDIRDNIRDTNRLDIRDNTRDTNRLDIRDNTRDNRDNIRDNTRDTRDNTRDNTRDIRDNRDNTRDTTNTNKHLADKIPYSHTFIFLDILNYKFKENEIHYSAMLLRECVNRNKDTSILITFLRSKVGVMSVETINYLFEFDYSFILNDYSRVRDKNVNERLKSMTIEVIRRRLRMYCNMGRLGGVSDSINTLHLVNNKYSEQQGVNNKYSEQQGLRDNSNIQQGVNNKYSEQQGVNNNINIQQGVRDNTYEQHPFNNTNTQHPLTITFGYSNTTITPQYTNLNNSSNSNNLSNINNNNNLNINNNLNINNNLNNNNNLNINNNLNITTLTIDLAGLEGSIEEFSKENEWRYNILSIFIDYKIRSNTVIEVCKNLITSKTSIKYKALSYLSIFMPDISYFNELIYAHHEYKEITLPALEYLLFHYNCNLFESLLLKVLRSEVLYKIHLSVTYPLIVKCNSLISYKVCFEVCDCIFRLYGTYILVHCKMASQLLSVILQVGSGGCGVVCGDMGGSGVVYGIRDSDRDRDSIGVSNSIGVSNSDRDSIGVSNSVRDSNSDNSSKYNNNTYTTNNYTNTPTNTPTNTPTNTSHIKCFIPSDTYLPFIEVFKMLYTLNFLNGCYLGNLPLPLFLTLDFNLIMNVEKIESVNLSKTVQEELEKCRLIVHRGDVDRSGGDIYRDRDNRYSNRDNCSNRDNRYNDSNNNYTNNYTNTNNYNNINTNTYNYTNTNTYTNNNTYTNINILNYKSQFIATLTSLKCNLFTDDCIFEELLSYFDVGFLLNVVSKYVSVEGVINSKTVFMILKYLIEECDECIEAVVGLLEVISKMGVSGGSVVYGVLLRKVRLMSSGGVSNTLLGNSGGNNTYNNTPLNTNTTNTPLNTNTTNSGNNTPLNTNTTNSGNNTLLNTNTTNSGNNTLLNTTNNIGNNTPLNTTNSISIWERVREGCNSIAENMLSKYDIYEREVLYDYMGMLISDENIEDSNKLRILKVLGEISEDEIFYLFVLSLFKKENCKFNALAISFYFNGLKFYAKEIRNDFYALLHKSINNEWHKRILYLFKFEWQKFKGNWLYCIFRLLLMNLECVGIETFKFCVYGDDSYFENMFSTEKVSNDTSVPVIQTFYSGSGVSGSVGGSKSNINNSIASKSNINNNQSTNNSTNNSTNNHTTNTTNNHTTNTTTGNPNIENFIGKEMTPFTTVVRKFKGVNILGVVCEMGYNSDSLVYEVFPRIFHAILEKMHKNEIQDIVYAFIDMAIKFKEINNRHDILGLRSIIHSFGLLKDIYSFGDNYMSLCHMCNSYNLFLEMVNEEQRMHIYEYLEEDDLYFGLLRTSSYFSETSDVALNHLLGESRTAILEYEGLMNKAKNGEMSFIKSEYDQWVSEWIKCAKELQDWDLIQELGNYTGDFGLITESSWRLSNFEIESDRSSFFNMLNLRKNCFDKKFYETFYLMYVNYDLNRIEELLKSATVEIGKIPRCSNKYFNMLQQIQVIVEMQEARHIFNFSKNNIENIKWVMKTWRERMPLSHYSIENWMVLCTWRYHIYNRISNLELSEISTKGMHDLARSLNCLGKTARRNRCYDLSHNSLSKVFMLSNIEVVDAFKKIEEELKCYLCEGKYLEGLELACGANIDYFTVKEKGKIFFYKGLFTYFIERDSMGVSNGVDGYKGVSNGVDGYRGVNVSDIPFSTNPYNNTYNNNPYSPTNNTSNNPYSPNNNTPIVNPYSPNNNPYSPNNNTPNNNPYSPNNNTPTNNPYSPNNNPYSPNNNTPTNNPYSPNNIPFTSHSPNTLYSSSSYTNSPNTPTTNPSYSNSPNTPYPNSPNTSYFNSKSEQLFLQSLQICPDVPECWYTYGIFMEKCYYECRRMGSREEYRREEIRPDIRREIKDNKDNKDYIKDNKDYIKDNKDYIKHNEDNKDYIKDNKDNKGEEFLIKAFQAFLKTCVLFTNNKSRISMMKIIKILLLASNSNTAIISNLTKEFEISINDLKIEFFFFFIRQFIDLLSTNSYECAIIFLKKAISIHPQAVHTYLSVADSEINLSLDNILDSLKSQEVLEERLNIENEFINYKEDINVLHDLLTNTNLSSVSYNDISLCKIAHERLNNLMSFYKTHHGFTCFTVDMVINNILQIFESNNEEHSFIVIDFLLKHIFDNYSNFDLRNNKGLEALLNRMLGVLSLSKICQKYYDEFKNDFFSTTEISLSQVFAKVYKWKYIIENMMKSMPYNIRLDVLSSFLIDYENAKYSEIYVFGQYIPIKESYHNLVKIESFEPVVMLSWKNGYCIRKLEIRGSNGKKYFFAMHSHDTSLYKREEKIMQAAMFLDKEVECGTEFLFSMNDMDCNTGGEECVEGNRNFDKNENRNTGTNENRNTGSTNTFRSTGTTDYGTTDNRNTGNRNTGSTGTTDYGTTDNRNTGSKKGDLGRSNASVLALKRKNARLSPKLAIRISYKIRLVSFRQSYFFLDDILNEWCTRIGYSYHYLAIKYMKYVDELAGRAVFFGCENDEDVGCSISVVNSNEIENNGDNGEGRGDGKQPEDCFMNIRNSSGDRLSSELKLGAYRKMVEFVSDSILKDRFLDYCGDFDVYFSFRKNFGVSFGSISWFIYMLGAYNREPSKLAIGLCDGSYYSLDVVPCLEEKYIFKNNESVNVRLTPNIQKFLGKEGVEGQMVSLFYNYSVFVKRGCLSDLIYVVINEDASFSEQLFFYKGLDEEKRIGFEKNIRVVMERMDMCCDGKKLLKMLNSSMDPENLCKIYTDIISDCAENVMMRQHVKRGSEIFELVLFKDLFVKACRKEKLFIHKGKDLIKLCESSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4G9</accession>
    <name>A0A4Q9M4G9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0011p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4G9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="478" mass="55959" checksum="D182DEAED3914B69" modified="2019-07-31" version="1">MAYFYKLVNGIDERHDGHYKKIQLIVLFIFSVFIMFIGIKYEKISFTFLLSIILICVFFEILEFLKSAIDEDRDIIKIPPYYFKDSVDYCYENIKIIELIVLLLSFILSIILLFFMTMALMVLYAIILILVYRAKYPERIFQKLGIENNITKVLIFICVGIIGFMLIKFHVCNILFAGIFSVCGSILFLASLETSLKQDWGYSNTIDGIKEGALPHCEKKQMCFEEIEYSHERGIFDQNEKFIGIYYKREIDVSTLQSISWVIKDVIILHFDCEKTFKVRFGHFENDLENNHFLISTIYLEKIISPKLLLRFLSLVTNLKINDSSEGLSMGQLMAILEFFKYLIPKRDTDYSGVVFSLIKNGISDDITDINLFNLFESHDFFVSMKTRNMKVSCKYSPNHTQNKLNLEYFDSYNLIIETTAVIIWTQFLKKDHKNNIFVRLLNLSNITCEYSMELASNQYPMILRNKHASRISDKLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5Y4</accession>
    <name>A0A4Q9M5Y4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0005p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5Y4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="21276" checksum="0DE3972744AFDFBF" modified="2019-07-31" version="1">MLEHTKRGFYSKRLARQEYKFKEQKKKIEEELNNIIPYKYNDMEEECNSGRGRTKKSDISSVHFPRKSMDKEVIKLEGLYEGEISSIIVKGGLTIGYEYYNEGVLIIGNIYVNRASIIRQVVLCYIVKGVLLLRDDLRGVSYKSHTIGMYNIYHYIKRGVINNHRTHHMDYPLFLFNKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JV78</accession>
    <name>A0A4V2JV78_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0367p0020</name>
        <name evidence="6" type="ORF">CWI38_0017p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000367">
        <property type="protein sequence ID" value="TBU03042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JV78"/>
    <dbReference type="STRING" id="1176355.A0A4V2JV78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0367p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0020"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="210" mass="23323" checksum="7DBB14D4414DE5A5" modified="2019-07-31" version="1">MKTILTGASVIAFKYDKGIILATDTQLSYGSLAKFSDVSRIHQVSASTLLGLSGEYSDIQYLLKILYLEISKDPVPLSPNGFHKLIQRILYGRRSDLEPLNVQVVVAGGDGTLKAVNHLGNFYSSDVIVTSLGQHLVTPFLRAKLENEIPNIDQAFSLIQEACLIEHYRDTKMSHTVQIATVEESNINISPPTKLNTDWKMGKLEEEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWP7</accession>
    <name>A0A4V2JWP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2223p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002223">
        <property type="protein sequence ID" value="TBU08752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2223p0010"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16861" checksum="853F70C76C3AA9E5" modified="2019-07-31" version="1" fragment="single">MYFKDKDSNINIKIDQVEKIFNDLRSRLVFMNKEIDNIGNDSFLKNIDVENENIKNTPKTLIENCSNENCGCHMNNCDNLYDTNHNLKHIICDQNKLETNDLTKEKLDTLYVFIDELSMKLKQLESEIVEKNQEIVNLKEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX42</accession>
    <name>A0A4V2JX42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit 1 of eukaryotic peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1828p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001828">
        <property type="protein sequence ID" value="TBU10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX42"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1828p0020"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="32113" checksum="3373F01FE0ADC321" modified="2019-07-31" version="1" fragment="single">EPIKPINTSLYMCDSKFHVDDLLRQYEDESKFGIIVMDGHSTLFSTVQGNVKTILQELTVDLPKKHGRGGQSSVRFARLRLEKRLNYIKKVAEIMNGIYLTDSKINVEGLILAGHSDFKNELKTCDVLDHKIREKIVKIVDVNYGGENGLNQAIELSEDVLKELKLSKEKNILKRFFEEMALDGKYCYSIKDTIQCLESGCIETLIVWENLSDKKDEEDFVDWISENYKEFGCELIFVTDKSAEGTQFVEAFGGIGGILRYKVEGINDFSDYESIDDNEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX49</accession>
    <name>A0A4V2JX49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Uracil-5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1844p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001844">
        <property type="protein sequence ID" value="TBU10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX49"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1844p0010"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="506" mass="58873" checksum="3911995B9B9C3A03" modified="2019-07-31" version="1">MLQYKISEIPRYATISQLKKSFVKNLKIKVSDFKITYVQKNDFGFIIFKESLSSQQLEQFENFYLKNNVKLKFRRLEDKEDGFFGKKLKEICFQSHNTVSMEIDIRDVVTTLWKMPYEEQLTYKSNTLESFYKNIYKNFISMKSSDTKVRNNCQFSFGFDKNNDIIVGFRGHKFIEYPNLVYNVSNCLNVSENMKNIVGNLNNILQDKKDLVFDRINKKGFLMILSVREFNDKSLSLIKIKSKDISLKEFSEIIDISRNILTDNSFLQISNDTFEGIKPEKNILSKELTDSFLNEIKTKYTQPDETLDISPVVICLKGHPDLETCLLSNFKFKISIFSFFQINTEVTEYLIQKIKKLKTTDTLLDLCCGTGMFSVCLNKDFNEIIGLELSKECISDAHRNIKINGINNITLVENTVEKAKFPDKECSVILDPPRNGVSNKLMNKIKNHIFIKEIFYISCAYEKTLNNILEVVSLIDLPSFKVEWIGGFDMFPNTKNTEVLIYLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB4</accession>
    <name>A0A4V2JXB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1349p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001349">
        <property type="protein sequence ID" value="TBU11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1349p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="867" mass="102192" checksum="7F170060808970B9" modified="2019-07-31" version="1">MVATCIGYDKAKNFYEKFLIWLYIFIWFGFAISYTFRYAFRKNGNYEILFFEEKRIECLSKNPGKCFKITYLCDENISFYSGKVHCFKYTKENFVNFEILNDILSLNSIASKIKNGMIECDYELIYFLKITKDIANISNTLTNNRFRNLLLTLKCLKAVENNNIIKLFHALIFIDIFSLNSYKKVQLDFKQIFDSCFANKIHFSIKNNLISAILNINMMKYVWYDGNLLFLENCKEKYDTSLFDEHIPYKNLLVNSYKVFCTLENILKNSYTFNSLKILLKIINIKAFIINNYLDLNSIPDIEHKFLILSMNIFESIIISYIDDFSSLFLYRLNGALKKDIEFLRFKNLSISKNNLDRFLRQRKLRGFLLGDVDYIDFFPYIELCMHLNDTLEYIFFRNVSIDINWWMDFLLRAKIHTIILSFDNSSLQESFIKAFIIQMCFKNVLYFDCTFCNLILTIDFCNSLSCWRNLKNLKLKGYETNEKTEIYLLKAIEGMKNLVYLTIGSYKIPPRFYNISLQKQKIKVLQLKNYSSRKKPLLVDLYSHFNKLTKLVLTKITISFSTMNEIFRLENLTSLSLKLCIVEPIGNLNHCIRSSRNLYMLNFYATDLKVISHLNIFETLELIEYLNLSCCNLPMGYLAKICTVSSSKLKKLSYGLGILDSNDLDAIKYFETLEELNLFGCVFHGTSFHKLDSMCKFFKSLRKLDLWLVKICMKDLKYLINFKYLKRMRLTPTGLDLLAVKNYLVLIPICRFEIDCISQEKTYDEFLKCLYEDPIYIVNTHKFRNISTVDSAKKYSGINFSDRRRGLDWGKASMCVNERAKMQKSPTFIKKQAISQADGVKVLKKIIINLCFGRRNGIRRTDNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ2</accession>
    <name>A0A4V2JXZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0357p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000357">
        <property type="protein sequence ID" value="TBU13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0357p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="103" mass="11589" checksum="60EC27E9C3511B5D" modified="2019-07-31" version="1" fragment="single">MDRLKFCLSKVNLANNGDLHFDDLYDYVHNDEKDNDKKNVESVTAKTIYVQQNNAKPHFSDNDADIVALGSADDRNIKFKVQLANSPNLNVLGLGFFNSIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KQW6</accession>
    <name>A0A4Q9KQW6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U1-C C2H2-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_2534p0010</name>
        <name evidence="6" type="ORF">CWI38_0207p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002534">
        <property type="protein sequence ID" value="TBT97053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000207">
        <property type="protein sequence ID" value="TBU19510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KQW6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KQW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2534p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0207p0020"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-C C2H2-type zinc finger" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT97053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="163" mass="19537" checksum="6509F992FA40CB08" modified="2019-07-31" version="1">MSRFYCDFCKVILPNCSQKSKETHRDGFKHKQLRTTYYNDMLSKKEIFSKINDTIYKIKMYNNIKQSEEVIKINEPSRKNIEKVEKKDENKIKSEFLNIFNESCNKIQNIKFEMPNFNIPPDFIYPPPPKNFRLPKDFDFSNISNFPKNMQEAIQKFTSDSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTV5</accession>
    <name>A0A4Q9KTV5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_2143p0010</name>
        <name evidence="14" type="ORF">CWI38_0873p0010</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002143">
        <property type="protein sequence ID" value="TBT97660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000873">
        <property type="protein sequence ID" value="TBU12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2143p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0873p0010"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBT97660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="89" mass="10415" checksum="5858A9E9B01DE136" modified="2019-07-31" version="1">MSALTLIKEGSTILCKAFFMTVWDIYCKKDTMSVSEARNILNINHNISKENLNYEYKRLYEDNDIKKGGSSYLQQKIYNAYQTVLKTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXX8</accession>
    <name>A0A4Q9KXX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory subunit of protein phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1202p0020</name>
        <name evidence="6" type="ORF">CWI38_0647p0020</name>
        <name evidence="5" type="ORF">CWI38_1038p0030</name>
        <name evidence="4" type="ORF">CWI38_1322p0020</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001202">
        <property type="protein sequence ID" value="TBT99826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001322">
        <property type="protein sequence ID" value="TBU11207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001038">
        <property type="protein sequence ID" value="TBU11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000647">
        <property type="protein sequence ID" value="TBU12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1202p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0647p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1038p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1322p0020"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT99826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="226" mass="26239" checksum="148D5A2B74DFEFA4" modified="2019-07-31" version="1">MDTNEEDVMYLSHSKVEKIPEISSKVRRVILNRNKIKEMEFLFHENIEDLDLNDNEIKNINGLENLPNLKILDLSFNLITQISNISLTHLRELYLISNDIEKIENLENLPNLIKLDLACNSIKKLENLINLPLLEELYLGNNYISKVENIEELKNLKVLALQNNSLEFVDCINIPVNVHSLLLCENFELSVVTNCNHLKFLKYLEIDKTQVKKENLNISRSVDIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYK1</accession>
    <name>A0A4Q9KYK1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1239p0020</name>
        <name evidence="2" type="ORF">CWI38_0018p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001239">
        <property type="protein sequence ID" value="TBT99724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1239p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0020"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="45939" checksum="008FF76CFA008BCE" modified="2019-07-31" version="1">MENYLGSFLKDINITERQKEAISKMLFLNEMQFKDLIEDLSDELERRKDGKKDFLETKNKYTVKRNDSRKRLAKLTENKFKNLVLDTYLVMNHRRPNEKFSDAKEIDTLIFELEKMIKTLKKQKTYEDSVIENIQDGGNIRLKSNIYNEYVRNILIKHNEDLSVVNYMEKIFNEHIHKLKKDEFLTLFDTNEFIGRCDNIFYEIKHFEREYEYHKNNILSQMIVSPSVKNLSELNTNNEFKNYVITNEMIQICRLLFKVNEYKKLQESESSLSKEINGLICCLEAIKEGFQTQKDDQCYIRIAINVNEIAKSFERKISKFDFVDHNHIKNLSNHQKNLENFIEANKDISNLEESRLFETFPNMVFNIADIFKQILNEIPGENDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBN2</accession>
    <name>A0A4Q9LBN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0030p0020</name>
        <name evidence="5" type="ORF">CWI38_0943p0030</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000030">
        <property type="protein sequence ID" value="TBU05249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000943">
        <property type="protein sequence ID" value="TBU12002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBN2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0030p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0943p0030"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="265" mass="31949" checksum="AF3AF9B0DA0F1A9C" modified="2019-07-31" version="1">MTHIFKNNILNKYGLCSDEDREKIIIGIESKVYRNVVSRNFREVIRVTDKALENLSMKMTPYDICSVVTPYNDEIQEMFGIGTYINASYIPTDLTHYIACQFPKKEFIHLFIELITKSNTKLIISLIDCKEYDYLENFKCIDRDVIKDEYDNDLFFDETYKITEKYFLRRLRFFKWKDFDIPTKSDFLKFYNYFNDIRSEDTNIIIHCKAGAGRTGAFIFYDILKHEKNVDNFIFTRKFLYLRYKRPRMVYNDKQLQYIAGFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD91</accession>
    <name>A0A4Q9LD91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2701p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002701">
        <property type="protein sequence ID" value="TBU05814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2701p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="10182" checksum="C2ED4D0BC2F629FA" modified="2019-07-31" version="1" fragment="single">KEDRIRKYLSFTKEDRIRKYLSFTKEDRIRKYLSFTKEDRIRKYLSFKKEDRIRKYLSFTKEDRIRKYLSFKKEDIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDV2</accession>
    <name>A0A4Q9LDV2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2653p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002653">
        <property type="protein sequence ID" value="TBU06044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2653p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19363" checksum="E268C53E74BF735E" modified="2019-07-31" version="1" fragment="single">ILDNEYAEIRLDTRIKTDAKIRNNIPKIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEMPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEELNTLFKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEI1</accession>
    <name>A0A4Q9LEI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2661p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002661">
        <property type="protein sequence ID" value="TBU06006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2661p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="17982" checksum="5EB1EB2D691BB054" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCSLAIPEGNRLMALRTIFDSVTADLKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEZ4</accession>
    <name>A0A4Q9LEZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2624p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002624">
        <property type="protein sequence ID" value="TBU06186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEZ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2624p0010"/>
    <dbReference type="OrthoDB" id="2192852at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="21263" checksum="C41A890926A37BB2" modified="2019-07-31" version="1" fragment="single">KDFVEIEKSENFMEYPAIFTDKNGTFSVFNLGKFPKNNNKQFYSSKYIYPIGYKSFRIFESFLSKNFRSQIYECTILSINNCLDMEIKVDDQYKFSGSSIWSNFCQKFEYPLPFCNVEEFFGLECKELMKKIESLGDITVFEGYQPIEMRKIYIYFLIFYLRLWECLNVLFIYNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG61</accession>
    <name>A0A4Q9LG61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2461p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002461">
        <property type="protein sequence ID" value="TBU07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2461p0020"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6159" checksum="3899700B946F06D3" modified="2019-07-31" version="1" fragment="single">NCVQDAFHQLEANTLDNVFTTLQACIESIMLADGGNGYKIPHLSKGKLRREDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIR0</accession>
    <name>A0A4Q9LIR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2309p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002309">
        <property type="protein sequence ID" value="TBU08079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2309p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="29994" checksum="CF74AD7071BC3CEF" modified="2019-07-31" version="1" fragment="single">MAIYHPLISKGIVDSVHAQHISEDSNEKEKENKNDILNKYFNWYKKNVNEDTQYNDILYVLHDPTQNEALMNHNIDINTIVDQNGNPIPDAKSKREILVNFLLYYKSFVNPNGQDRHPHAKKRHDISKKTYAISDINKNFKEDVNQNIQKPINYSDLDSAETHSNEKYDKFVQIFQNQENTETLNSLNNNDFNENHDIFPPQYFSNTYPGATEDKIDFYPNTTESNMTKSKYPDNKSYMPGVHSNIYRFSNTDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJT6</accession>
    <name>A0A4Q9LJT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2320p0010</name>
        <name evidence="3" type="ORF">CWI38_2384p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002320">
        <property type="protein sequence ID" value="TBT97362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002384">
        <property type="protein sequence ID" value="TBU07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2320p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2384p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="255" mass="29515" checksum="3C096E8B3C2B2EC2" modified="2019-07-31" version="1">MPFWKTKIFKILVLIFAAQIIVWLILGSIGYNKACSAIKKFEEDYKKVSETDKFKEHLSKTKNTNKAFFLILEGFKIFWIVNPKDDIINIKKPNATQGGNYNSGTLEITNNINLETIEKASSASDLFVFEPSDFTKILPNVGFLTRIGFIFKKNHPIVAIHKSCKIFDEELNQHTKDKERSFVVLEMIDDKKINIYKLHMKNTENKFRGKMIDLTFASAKINDKMCVVSDYITYIVEKVFKETSEDAILNEFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKV0</accession>
    <name>A0A4Q9LKV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2232p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002232">
        <property type="protein sequence ID" value="TBU08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKV0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2232p0010"/>
    <dbReference type="OrthoDB" id="2189670at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="31807" checksum="7542F5F37BE6D75E" modified="2019-07-31" version="1">MEKYLSKTIKGEYGNEISKLKDFFSLKNGHILVASMDIYLLTEVIKISLSNQQRYKKSIEENNYFDENIEFSNSYLVYYLDKKKSTSELYFLLEKSKTQDDFHLILTTISCMALENLDKRIKSRLNHNIIFLPVLPYKSVKQYVNEKAHKIDPRFSALLKNNLMQKYKINFDFESLFNILNSIHISLLIMILNCNIKNHKMIEQYRKFVFKHPELRNIKDKDISDALGDLLDLGFLDKKYNYVFSVDELKNYISKNRPFYLKRLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLH7</accession>
    <name>A0A4Q9LLH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2204p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002204">
        <property type="protein sequence ID" value="TBU08937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2204p0010"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="20054" checksum="E31F2376242EE632" modified="2019-07-31" version="1" fragment="single">ISSNLHNFEYFKCFLLSNYKINIELEEVYNENFQEKNKIITSLIFKRSLNIKDNIIIVCANIHECIKTGQELRIKMSTITDTCIKNYDENYGVYWNTKPFKESKIVLLTLKEAKVFCKNEIVIFKGLYDGKNELYNFSEIFRLFDERKIIIYENRNFITFFKSLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLJ3</accession>
    <name>A0A4Q9LLJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2173p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002173">
        <property type="protein sequence ID" value="TBU09203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2173p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="21452" checksum="128780804C03BC1A" modified="2019-07-31" version="1">MNTYNNCEAIPARNTYLFQNNYENSAAYYNQQIYQGQQACSFNMYETSLNRFSHSTSTVYPWFTNYAPSQSSSDINMQRNWSLFTEKFSKIKKIDYDSPLVSFFPGIIMLKDFIYKLLLEKVLQDRNIFNIFVGMKMIESLLFSSKEKISSFCNENSLDIFSYRHGVKNIINVHKKMFFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNS1</accession>
    <name>A0A4Q9LNS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2027p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002027">
        <property type="protein sequence ID" value="TBU10093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2027p0010"/>
    <dbReference type="OrthoDB" id="2195759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="20032" checksum="802353C7C884C70C" modified="2019-07-31" version="1" fragment="single">LSIRNIQHENLCFLWSDLNIILNLNDKNMEKKYKNFYFDTQKNFNNAVMPYLIKQKYHFAIELLEMKKSFDDSLVFKEVEKNQILAENSKTMFSDILGYKCEYLFSKMTINSRENEFIGFSLGTIYNPKISGENGINLLDNGVVELGEDGVFIELVKDIYKYQETIFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNZ8</accession>
    <name>A0A4Q9LNZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1967p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001967">
        <property type="protein sequence ID" value="TBU10173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1967p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27577" checksum="004CC07639BC8BA6" modified="2019-07-31" version="1">MSVESLKISNNIFKGKNPSNTYILDKNIRNITILRYLLKYTLFWLFSSIPFNIYCETQEDTNMRLSNLNDNPFIFGKEDKIRKMVIKDESSYDERDMEIIRKHKGKPIKLGKNKIIEKVIKEESSYDDGDMEIIRYINGKPIKFKRFVDKIVKENEKKDKNEDNEKKRVDKYRDILRDKFKTSPVRNKKKKGDKNVGGINTKTYYSLKYGTPNVGVNKVINLYYVKGVLKLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP11</accession>
    <name>A0A4Q9LP11_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2189p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002189">
        <property type="protein sequence ID" value="TBU09060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP11"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2189p0020"/>
    <dbReference type="OrthoDB" id="2191304at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="3">
        <location>
            <begin position="510"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU09060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="575" mass="66318" checksum="2E428CA889C7F995" modified="2019-07-31" version="1" fragment="single">SMISNKEKNIEKSLSNLTEVKNNFKTKINNSKEEKNIEKSLSNLTEEENTTDSMISNKEKNIEKSLSNLTEVKNNFKTKLNNSKEDTNEYFDENRKFIKNMENTNYKNTDKKIDLNSEGNLLNNQAIIKGKEYNLDTKNRNLIIKNGENIKNNSNKSVNLVTIGGQDGNSLKNEVGMLNCTEKNKSKKLLREDFGDPSSMDFKGPWARFIDTEIQNLELDRIKMIKEEIDWCLRMKNPFFVIGSEKSKYYGNIINNNKISANYLRRPIGYNKYLEHSIERIPKVCDLTITDHIRSVRKVLFLKRYSNLLLSGGLDGKICLIESFEEKKTIRTFLGHSKGISGILSSTDGKTMISGSYDGFVKEWDIETGRCKRRIETKDYVTGLAGFSNDYFYVGCYDGSIKLYDKRTKNVENEMKFNDGFVKEIICLNNDNTLVCSFENKSLKVLENNFKIFKEYKNLIGYSSLSINLIKKNIFFREGSESLKFLDLNTFEILEKTIKIFPDNGIYCELGVSPNGQRIFSGDKNGKAYFYDWDTGKCVRNIQMHTDAIRCMAWNEEDVSKFATGGDDNFLHLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP59</accession>
    <name>A0A4Q9LP59_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1917p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001917">
        <property type="protein sequence ID" value="TBU10243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP59"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1917p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="57867" checksum="0C3758F96453B21A" modified="2019-07-31" version="1" fragment="single">DSKIHILSPIQKRLILIANELVTIPRILFIDDVLKEIDDNTASNLFNYMKYLSIYHNVTVIFTIDRPTSKIFALSSHITLLSDSHTVYFGKTKKAEKYFEYYGLKKPESATFPEFISEILKTKNKYSEIKAHQNRLNKIINNVKTNPVPEKMLSSNGNGTKICKSLSVWNISIIANRQCKMYVTYKKIFVFLFLFGFIYLILFKYIFIFMNKDYFGNKLINIYSLVKNYVTDQSVHRFMDLIKIHSSQISKILQNSVVLQPMGILFAFLLIPSSNIFYFEHQMVKKELAMAKYSIGSYYIATFLSEFFFYFPYCFAIQILSGLFFSKKLGWGFHIFLIFGLYAYLPVFLFFGSFIKRTGMRYLIISFLALFWITPPFMYSILRNLYTKKQNLLGLVFLVISALFPPLHYNAFCVALAYKTDSYKSRFLEKNPSVKELSDRFAEYLYSYLFDSMNIWYIVLFFFITSTIYIYFTIYALRKLLTPEHRFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ26</accession>
    <name>A0A4Q9LQ26_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2146p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002146">
        <property type="protein sequence ID" value="TBU09470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ26"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2146p0030"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU09470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="12473" checksum="9A191B562E740620" modified="2019-07-31" version="1">MNDKHTFEKDLEFIQSLCNPQYLQHLHQTGYFFNQDFINYLKYLKYWMYEPYSKCLIYPQCLIILELVNDETFRFKLSDDNLYFLIGDQQYNIWKNKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK0</accession>
    <name>A0A4Q9LQK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1632p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001632">
        <property type="protein sequence ID" value="TBU10644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1632p0030"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16044" checksum="69BD3AD795E5E714" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINARCSNYNRELPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSARRPANTMENLNAPVISEVNRLMVLYSILDSVTAVEQECPRSAISAVQKRFERMPRNGWSAILRYYNGKFGRTVDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM7</accession>
    <name>A0A4Q9LQM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1727p0010</name>
        <name evidence="10" type="ORF">CWI38_0885p0020</name>
        <name evidence="9" type="ORF">CWI38_1617p0020</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001727">
        <property type="protein sequence ID" value="TBT98501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001617">
        <property type="protein sequence ID" value="TBU10674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000885">
        <property type="protein sequence ID" value="TBU12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1727p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0885p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1617p0020"/>
    <dbReference type="OrthoDB" id="2196280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT98501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="156" mass="17513" checksum="96A87C928B656DD0" modified="2019-07-31" version="1">MIGLYPSAGRFFIYLLIQASLLLFSIALTLTIGTYSPSENFSQVLGTTIIIIFIIFGGSFSNPNTIPSWLSWIIWISPIQYGFKASMQNQFDGLEFICNDNDPRCIESGNDVIILYGMESPSIWPCILTLWGLTVFWIFIGAIGLHFLTKISLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR14</accession>
    <name>A0A4Q9LR14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2057p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002057">
        <property type="protein sequence ID" value="TBU10061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR14"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2057p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="327" mass="38478" checksum="2375B5B5F69E4D02" modified="2019-07-31" version="1" fragment="single">YARELEFYEKLSDENIIQKIFSFKQDGIGYIAFEYFPCTLLDIADEIKNITFIDLKIIHKQLLDALLYLEGEGVIHNNLKHNNVVVDKDLNIKIIDFGMACYIKDLYKVFKDENLDIEKLKEEYPHCSPERLIGADQNFKTDIYSWGYMLKTSSKLFVSQNQEFLYPDLIDIYEHALQVEVSARPSVDELIFHPFFDEIYNFLFCFNDYEDMKGNINNTLFDKIGNKILIRHSQFEFAIYCGCHNEKNDETVTRLLTTKIHSEKCTVCKTGFKISKYAKFKLEVSGQFFPIHILKMKYIKLIREDFLVFKSQIRLKSNPSIGLQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI4</accession>
    <name>A0A4Q9LRI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0107p0030</name>
        <name evidence="3" type="ORF">CWI38_2048p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000107">
        <property type="protein sequence ID" value="TBU04641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002048">
        <property type="protein sequence ID" value="TBU10070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0107p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2048p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445367" evidence="1">
        <location>
            <begin position="18"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="609" mass="71860" checksum="4A0E18D170F819CC" modified="2019-07-31" version="1">MLFFFLLTKEFIKCSTATNEDNQLSISDIPHTSTNHIDVKYSQQLSKKVDIEKRRKQERLSELITDLTKKRKLELDSLETEKPLCTQSFLSNSSSDNLTKTCEIDKSVREDQEKMPVLSDKIDIMTPIDLTYSDPHSIHICNLEKRKLIDSEESTQFGLKNSKVSRLAVNQAKQGTQKTKEFDFEKYITEQFEGLEISGVVTELSIKPGSNLSNLDDRIRNFKDNIKKFTEYICGKTSNTKHGDSTNYILTNQNIFDKLKQEKLFIKNNFSLYNSDHIERIFLFALSLVEFEKNLQGDNKLDLKAFAINKAEFMDFEKKFKDYQGIFSIHELIVIKNIYNTCFKQKTQDGYILYTYFLFEIFFTNMEIILTNFESISKKPKNDSDNIKETYKRKPEVINADIDIIFLKTILLRVIYGIKDGPSIAKKYTSILILDFKKIFKDYDNNTHETLQNTRIKINILYTDVLCSNMSDGNFEDFAKKLNNIFYFKCYLRLGFLDLNNFEINNISKIKSKYDEFIEELLKAIQSSYNNYRKKIKVGVKRKEVFELYKNINVCGNPKKELVQLQLYFLEFYLCYLRKLLYPQYQYEIYISDHCWNVRFKKFESINQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK4</accession>
    <name>A0A4Q9LRK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1987p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001987">
        <property type="protein sequence ID" value="TBU10145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1987p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="991" mass="118708" checksum="B5FD55D27F48F72F" modified="2019-07-31" version="1" fragment="single">MEILRKSLSLKEKNQKVKFFVNSLLKKDDLSDLFSDTDDPFSLSKIGKTCLLQWNTILEKYEGILKAESHEHFHNLFQVKGFEASLKSRLILLFKILIYIMRNTHNHELYIIDSTHANFLYSSDTDISFYSFLFHNEFYNNFTHPHNTMTIRYFNSLDLSYFTEKKYEISSDFENDIIDISFTYKEKCITDFQNEGQKNIQNNVFDAPLPVLSELYSKYSNGLLLCSQIFRYEFYKNSESQKLLSIEILANLLYLKIHSKVQLEIILYSVYFFCTNLLEDCFLDSLSILSTNIFLIAKYHIETEETVFLRNVIEHISLKLDSCSIILKNEIYSWLKTRFYILLNFLNKDFIKKQKPTNLFLEMDSKNIFMYICYILYDQSIFIDFMNGFISNNTSQILNDFYFKIFHEDTNYEIKDVFGVYCRNHEDYNEYKLLFYQIFAKIIIYFVENPHLNEHNGIIYPFCEYFYRFTENIILYNSTFIDHVCEIILAIFSHSGNNKVLFYKFPILKNILKYYFYQSKNDTTVFFIHNIIYLIRLNANYYLFYNDSLFLENFIDVWFKNAELSVYLLLFPLEKYMMLTYIQIYLNNQKIYIFNLDLLLCHLNDMNTLSNVDMNVFLNFKKLSVPFSFTSKYFDFLKSINEYNIVETCSCYDFHYKHVLELSEMILNSVYLKIKYETEIDIYSAIQIEDYHYYCTDVSFLLKINYLIVKKLASNFSEKFLVFESIHRFISNIEIGILLDLVSLDKTNPNYYKKISKSFVFLKHLEENIEHVYSIEQHISRYECIKRIIGIVTLIYKRMFLSIKLPIISISSDEINIMDLDSKLNVLNNSDMDIISFIFEQNYVLILKLLLRFQKFPRIIPPEDCNKSIGFIYFIHKISSDMVTSDPNLISIYFRYINQNIGILYKYEYKELINLLQILINHSVKYYSTYQIDLQSVKNKILKILRSLVNRINIFNETKIYEFIDLTFDFLEENISLLSLEDFLLFLNELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU8</accession>
    <name>A0A4Q9LRU8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1450p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001450">
        <property type="protein sequence ID" value="TBU10977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1450p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="546" mass="62612" checksum="549BC45C98C9B7FE" modified="2019-07-31" version="1" fragment="single">MTGGQIEKLEKNLNGVELKSKHIILQLLDCCRNLKVNLPEEQQSPKVENNTKTHLKLTKKLFKSIIRVIRGSPNEEIRNSINDPSNWLTKGNLRPRDKAVIFYIQDIEDGVCQHSSKSGKTVDHLANRCEKRLDHNYTIRHNEVLQRINLLLLNRYHFESSKQIRSHSVQKILDNEVEIIPCVVPWDGIVTKYYKMCLKKIQIFINAEECIESIILEKIVKTISFDPQEDLSWTKCRRKQPTLPLKQVDNDANGSDLNDRSSEKQKEKIIKAANRASEVDVVIRECKNDQGIPQPSSYTPSTIINNTSISPSEANTNTKVCLLNTIPSPSNPMHSSTVTPWPDIAANGPNLCTIPISESLVVLRSILRSIEAERQEFIRCVFFAVQTSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDATRFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDTTVLDLINRIVGEYADYHVPMTITDIARIIQTAQVCYDDETRKERPRSAWKESFESKISVLKLSKDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU9</accession>
    <name>A0A4Q9LRU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1289p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001289">
        <property type="protein sequence ID" value="TBU11273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1289p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="41600" checksum="0814F7EC2D3D1492" modified="2019-07-31" version="1">MTKISGVKIEEKQIYLLSESQDNESVWVTAKKFSLDIINEYFNKTYAEISQIIKNMNSDISEGIKGDDTDILTDKLTIQDEYEQLANDEVDILGKRDESGRMTLKIKQEQPYTVSSQNIDEEKEFCIESVNSDEEEFLENLSDDFRSFRNRKNVLKNNQTEQSSICNTDTSENISDFNNIKTPFLFGHLSGDSVMSDLTKYGSANQSTTLSNKEPSIEKTNNYNFNKKKVKTSNSKNSEKVKKVKITSSKENKDIQIYKKNEDSEIDIYDNFIFTRKKNVRNIKFYTGVWFNPNENRKRVSLKFVKIPNKKSILRANQTLFQTGKVKKQIDDSNDIFISRQGKRIDGLSLLGLLEESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS44</accession>
    <name>A0A4Q9LS44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1477p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001477">
        <property type="protein sequence ID" value="TBU10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1477p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="37322" checksum="733C48FD43D81242" modified="2019-07-31" version="1" fragment="single">GVLFLKYLINKLSPSNKLNKQMKIAFYGEIIYNEIPKDCNYIEIISNEETVYYKANIPYYIKPLDYISHLNGNICRYEWYESIKIIFNFVFVENFLVKKGLLNFREFENEEVINNKITIKGNNIYQIYNPIRKLYEYFDGKYIYLECEFERQFIPKYSNLNLIIENTEFDILKKVVEKNKIYYKIRISLNESHLIYLFSENNFLFRIESKLNLKYNFIFHFYTKKNKMLNIFVGKICEKWNDKTLIIKLNKNDDAFEEDILEVKKKFSEYTLPFKEIHKNQIIIEIENNEFHLTEELIRLQFFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR4</accession>
    <name>A0A4Q9LSR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1653p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001653">
        <property type="protein sequence ID" value="TBU10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1653p0020"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="638" mass="72244" checksum="A38E485707EF60C0" modified="2019-07-31" version="1" fragment="single">MDKPIIFSQKLVFFLNHNNHRTSAYTEIHLITPTPTITFNINHLEITNLIITEDNQKYSLQDNKKGSNRYNKDNKYCNKDNKDTYNSNKDTSKDSNNTLLNDSISNNTLLNTSSGNNTMLNNSSGNNTLLNDSSGNNTPLTNPHINNTLYTLINNKSLTLPINTPLKITIEYEIPINNPAILTHQIDNHIEILGTNTHTSLFPYINTPTSYIITYVIPITPDLTLVSPGVLQGTTVHTTNKASDKTKDENRDKRVLDTSSSNKGVLDTSSSNKGVLDTCGSNKGVLDNSSSNKGVLDNTANNTTPIHTNTTDNTSFNIYTYKIPFTNPTHISFILGTFEIHDISTNIYLYIPLCLINKIKDSLTEITGDILNIHKITETFTQTTIINNNTPLFNSTNNSINNTPLFNNTNNPTNNTPLFNNTNNTINNTPLFNNPTNPTNNTTFSYIPFKKLSLIFPMSFITPFVSHESIYINTSYLPISTSSYNTSKDINNKHIPNTLTLPPIEHLYSLKYKLSKMYSILILQHPYNIQDSFIYKGLQGYIKDNILRIILGNTSYIYNIYKYKEYVISKDIKEYPLYSVKRNNYSSFFFLTKSTLFFHVLENNLSRAFMQRIVNRIIMFNNTWVISGVMVGGVSNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST6</accession>
    <name>A0A4Q9LST6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1549p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001549">
        <property type="protein sequence ID" value="TBU10791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1549p0030"/>
    <dbReference type="OrthoDB" id="2191542at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="472" mass="55551" checksum="55332B2F07A29D7C" modified="2019-07-31" version="1">MKISQISKTSKDNISISTLLGSKIYISDSKSIYFRNVYNYDQVTFLKFKSKKKIDALYTFGEYLIVLCGNVVFLCQQSEDVLIVINEFLVEDIPTRVKISSISDENFIIFIFNADYIQIYSKKDGLELIEVNNKIKNINTGNITDIFNTNDKSYVLTENGFIFDIPSILYSYRCILKNPLKMIPEPVHFIYEKADKIIVLNNKICICYGTGYEIYKKEFGVLNLDHIYKKNNANISIYKKNLFCYGDELILIEDKPLLLSKDIILGFYGNICVSEKYIFYIEFQEKNLNQYFGRKSSLIKERDPNDRASMLLESVSNRKRELLKIKEKTNKMSDLIFEKIFTKFRTELLDEYKIIFIELNSMKESFPEKENVLISKENDLKRKVEFVENKYQILNEKLCLLEERINAIYKNLKNDSFDEKLQSEIVAIRKELKSKELNRCDRKNSLKDLLSKLRLQKQILSGMVFRSIKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ4</accession>
    <name>A0A4Q9LSZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1602p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001602">
        <property type="protein sequence ID" value="TBU10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1602p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="50" mass="6036" checksum="CA0509E27E2DB5AC" modified="2019-07-31" version="1">MTNILNDILKYQIGNTLPDISILMKYDYFFNNILCQEQLEILFFDIFKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT48</accession>
    <name>A0A4Q9LT48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1122p0010</name>
        <name evidence="3" type="ORF">CWI38_1566p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001122">
        <property type="protein sequence ID" value="TBU00064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001566">
        <property type="protein sequence ID" value="TBU10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT48"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1122p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1566p0020"/>
    <dbReference type="OrthoDB" id="2186843at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="428" mass="51048" checksum="58BD8CBFDFB206A7" modified="2019-07-31" version="1">MVVRGYIIPDQKKYVSKTLIKGKFKIDEDSFNELCILSNIYPKLCKRKQKYDKRNDIYYLIADIKKIYLSDLHRNIKINQRIKKMRYKYLKREEIFREIKEDLGDGRFKGEERIGEMRDGMVVGEEILESKKIDKGNIEDGNLEKENSKVENIKKNELDENINIRDSNISIPYKTDKVYKFKKYNFAEILKNKYPSLLDSMKGLKESLCTIVLCKTVMKYECTEIINKYKNFMIKHKILKKTFIGKTGICYLLTFDGLEIVWIYSYDYENENKDDEIKNMNVLKYLYGICNAHLKFLLFKLEKIYSVKENTNGVFKNFKFYILDEKFKEHISFVVMAGDGNISNTKEESDYVIGISTTQELFVHPQFVFDSFNANKILDHYKYMSPNNLPDHKFPFDYNFYENITELQTMIMSKNTKERIKEHDKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT66</accession>
    <name>A0A4Q9LT66_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1556p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001556">
        <property type="protein sequence ID" value="TBU10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1556p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="26584" checksum="74266692A48FD8C8" modified="2019-07-31" version="1">MMIALPEIYFDKTNNINLNRSADQIFYITELYLSNINDRIDFLKLSEKNKYFDFKATNKDILDSEYPINSLKFLFQNYDLSSIKQLSISDFSIDNLNVKAFSNLLDLKEINIYKINFQNICFSELFCASREYKIKRMELNEINISEQDLIFIENLKKIKDIIFWWCDIHEMTFFKIKFLFLNEFYIELKYNREEDDLPNKTIKFIKEKFKKKYIVVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTB6</accession>
    <name>A0A4Q9LTB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1008p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001008">
        <property type="protein sequence ID" value="TBU11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1008p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020984616" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39262" checksum="265002B6415B74E5" modified="2019-07-31" version="1">MCISYKIIFVQIFIFLESIFSENIKKEFTDIELVVFSYQNVNKRLFLSEKKDLLFKESNLLNVKEEIFKFINNGNNSYLINLDDKNICYFDTSETIKPCKKHHGLESWEIVHKEDGFLIKSKFRSKIFPLLRKCLSVDSTEDVKTKTYKVKPAKCNAKDKNQIFNFQRYFDSISEVTNTKKSSNYTHESYYTTNVSSSTNKLQSPDSTQNSSSINNFQNNGIKTYKPFQSKSYIDNLIRINNSIASEVAKNNQANHIDTYFYESEVPTQYPPTHAIPQYTPPKHTPLPYTQPDTHLSHKEIPHSHQPYHNHSSYPSQSFYANISSIESLCTSHPSICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH7</accession>
    <name>A0A4Q9LTH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0199p0020</name>
        <name evidence="4" type="ORF">CWI38_0990p0010</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000990">
        <property type="protein sequence ID" value="TBU11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000199">
        <property type="protein sequence ID" value="TBU19799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0199p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0990p0010"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="511"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="309"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1063" mass="124118" checksum="7FAB8C02F1B06737" modified="2019-07-31" version="1">MYIRKLNINNFKSFYGLNTITFSSGKTFIIGKNGSGKSNLLSALHLLITPKILSSIQIESLLYENSNDTTSWIEGLFSNERGIFPSTEFFTLKRCFSLGKDEYFLNEKHISHKDLADMFENCGISTLITENQNLEETNLKGDEIENITNRENDLNQEVMENKNMTPCPTFSNPFIYIPQNTITRISNLSPKDLYVLLQEISGTVLYEQDKESIKGLLDSTVHSEKKIETFYQTLQTRMLHLKRQRDLLKEYESLEKKKKSIEYKIFKNEMSNIDKEINEIESHKTMGINSKETEIESDSTEENEKSFKLRNYRSQIENLLKKRTKIVQQKENLKNEIQTEFKTTDIKEIEEKETLESITTQIQEIVRKKEKIQEELKNVKNSLNNLQEEHEESILNLKVMEYEEGFFKVYDPENNEIEIKRTEENLKIKETELKELENKKMKTENKKNLDSEDLKIENYNFLIDKRKSLWRDQKKTKENILSLKEKLTTVQNKVYISCLSYSSYLEIKNIQGIYGCVFELIDIPEDLFKAVESVCRNSLFNVVCENEDVATNVIPKLKNSVTFIPLNRIEINYKSKNIENAVPIDSFIKCDEKFKTVVKMVTKGCYLVSDIKTAVAISRLHNVNTVTRDGDYVSRKGGVSCGIDGKGFLREIRELLVMKDIKEEDLKKIENEISILSEKIQFLDSIETKNSEVFDSSDTFSLRVLILFMHKKIKLLKNGISQSFMRSHKNDLEILKNKIVKIKSMIEENTNFEHSFTKKINEIGDKIRFLYKTKEYFALKEDENYIDAGVEMLRYKITKHMESEYKIPKQADFSSFEFEKQAVRKNILIEKKMNIKNKLRELASFYENNSLVFKEESNEFLYKKLSEINEKLKKYASVNKRTISLYNSCFEQNESICKRIEELKIGKVEIKTFLEELEERSKESIASTFLLLKKYFKIFYNDLMEGNGDLILTENEMKIITHVGDTAMSGGQKTLVALSLLFSIQKIEPSPFYFFDEIDANLDSNSRKKLLSVLKNIESQFIFTTFRNDMLDIGDKFFGVLFSDKKSSVSEIDKSTAKEFLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI6</accession>
    <name>A0A4Q9LTI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0811p0010</name>
        <name evidence="3" type="ORF">CWI38_1408p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000811">
        <property type="protein sequence ID" value="TBU01084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001408">
        <property type="protein sequence ID" value="TBU11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0811p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1408p0030"/>
    <dbReference type="OrthoDB" id="2200505at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031502">
        <property type="entry name" value="Zf_ribonucleo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17026">
        <property type="entry name" value="zf-RRPl_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="228" mass="27944" checksum="65382278E7B949D4" modified="2019-07-31" version="1">MKIKECGFCRSKKLVFLLEKIYCEECEVYFKFKNNNYEACHLPTTDINNCIPIRRQICDKCIETDLEKSIRCRNFNEYFLKVHFCNFCKDKLRLYMKTLFYKRVMLYKQQKRVVGFRSLLFYIFIALFSIFYRVFRPFVFLYHEKYAFKLSISFIFKRLIFLLLYFSIGKEVCYVFFLIYSLYSLTLLIETYFLVPLILDENQNDDNLLVEHIDRLRIEEKDTKPDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT7</accession>
    <name>A0A4Q9LTT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0923p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000923">
        <property type="protein sequence ID" value="TBU12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0923p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="61200" checksum="AC6713F27308EA2F" modified="2019-07-31" version="1" fragment="single">MDAFPFKFPTESRFGEKNDQNLYISANIITFEEFFYFYKTILEFPYLIDNINEEKYLLFIKILNIFKFERNSSFKNLIRYIWCSIIFNSVPIKERNFTSKKLQNLDQPKYIDLSKMVLVEILEIFKFSKEAISIIKDISIMGRKKNVSSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPQPPSQTCSKMQNSGLDTLLSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRHYNEKFSCTETLEVLKKLAQGEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINPRDKFLSKIKEISMKEIRNVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKEKIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNVSLNVYEKKITMYESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU15</accession>
    <name>A0A4Q9LU15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1088p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001088">
        <property type="protein sequence ID" value="TBU11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1088p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="38782" checksum="3907ABF30FBA5585" modified="2019-07-31" version="1">MEIELIKYLFDKENGIEYDKYIFEDIEISGLKFDIFPNLDIKNSTQEIFLCRHITTSDFEIFYRFIISYYFLYEKMTIESFYTILYFLEYLRVQYDSKLRKNDVVDKIQLHFSKQKIFSHAYFKIISQEYFKEFKHENNFEPWIFIKEKNFVLFEKYESLYTANRKYLLLLKGNFFEKFSKKITGNVKRKNLFIILLNTFDLKYLDIHDLESKYLKICCFILDNLKKTLDEIVFYNICVRDKLIISLNTNQTFIHLKKIVFLESKIKTKLKFSNNLNKIEEFIFNDSCIINKQNSISEYQILERLEDIKNIIINSQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU70</accession>
    <name>A0A4Q9LU70_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0857p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000857">
        <property type="protein sequence ID" value="TBU12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0857p0010"/>
    <dbReference type="OrthoDB" id="10027416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020222710" description="Leucine rich repeat protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="89579" checksum="7D84C4EC2B0AC564" modified="2019-07-31" version="1">MIYNIFLLLMTVLTTEIQMFNLIKTKISDIKVKNTDKNNWISIFTYKDISYHYRNADNHIFRYPKDFFVRLYGFERLENIFIKEYNTNQVLYVLNRLKDFDYMNRMINTKEFLVYIDILLLFEVELGRNIKGLIFSQITNLKFINYDFASNYKKFNYNSNVQNLFLIILKQFLKYNLLTKQDIHEFFGKSDIKKNAKKIFEIKKKFRDEIRFVLTDSILQKIYKIANGDTRKQEFIKYIFSNIKIKRLTIMNTQSLNNLLQINRSARLFLYSTINELKFDSVRISSTFLLIFSRMNIFREIETLIFYNTTINSLHFYELNHFKNIKKLVFNNSLKGDYIYEYFQMLNESLPELKVLKIFEFNMKRMFNRNIIYFEKLENLKLKFMTELTDSLVFDKAFIHSFARKLTYFEGRFDFLRLSEIFFSLNDFPLLKTVILHGNQYTYLKKNLNPDISNLRFQKNLKILKISISVIKEYELYSIMNFNNLKMLKFNYCVFDISSEFFLNQNASLSKVKKIRFRYTKFPLNIFTYIIRSESLNCIDLSYSLDILNISICLINFRNKQNIIKINLSGKYLEDLTRNIFKGFSDLKDLNLSNTTRYGGDLIHILNTDICRSLEVFKYDKNTINAEDIRSIEQIKNLKYLSMLRCHFIDNCGFIPACIPIYRTLKHIDCSYSKLPYNFIKSLALFKKLRIFKLLYIEINHRKLKVLQNTSPNCKILTNEQNLSNAKAFNYIKEQFSEENILCANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH9</accession>
    <name>A0A4Q9LUH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0847p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000847">
        <property type="protein sequence ID" value="TBU12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0847p0010"/>
    <dbReference type="OrthoDB" id="2196280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="32079" checksum="6CD5CDDA4EA506D9" modified="2019-07-31" version="1">MIGLYPSAGRFFIYLLIQASLLLFSIALTLTIGTYSPSENFSQVLGTTIIIIFIIFGGSFSNPNTIPSWLSWIIWISPIQYGFKASMQNQFDGLEFICNDNDPRCIESGNDVIILYGMESPSIWPCILTLWGLTVFWIFIGAIDSLQIVETEKLKKYGLLANKLGLIDKFSVGIVAKYHKSLLKILQISMNVESKTIFFDRRRGLEGQTPFKTNDNKEDDEPTINMDEESNSEEEKSWYKRQKKMHKSGIKTFYPENLLNKSIYNLKNLNTIFANKETKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM4</accession>
    <name>A0A4Q9LUM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0971p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000971">
        <property type="protein sequence ID" value="TBU11936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0971p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020479931" evidence="1">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26101" checksum="BA8D279D15508E95" modified="2019-07-31" version="1">MSKLLCATLFFIFEIIKGTNEANIEAQKNESLQRMINEAINDIQDFSDNIETTAIRGVENFEMIDSEETSFVSALNEENFVNVPNNIASTQALNGKNKCGGFFIPGLGFKFIDANSPLFPIHQRISRIRIEIDLFNKIVRDISKRIQQKKLKFAFSDFIINSLKVVGSFSESNIHSFHIFIVKTENILKACGASRIIFSLVLKFADNHCQDFESTIGMLNDNLKMILDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU2</accession>
    <name>A0A4Q9LUU2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1235p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001235">
        <property type="protein sequence ID" value="TBU11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1235p0010"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="8">
        <location>
            <begin position="186"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="471" mass="55397" checksum="9468E24A58B8E534" modified="2019-07-31" version="1">MDPKFSIITHSDKGLLLSLNQEMNDMVRLSNITGLEVERCVYSNTVILIYSKEKVILYDIKNGKQISEFVMKEIKEMKISDSENLYAFLSLERIFYVFTKEKIIFQEKFVEKFSFSDDYLLILKNGEATVYKIMNNEFNIISKERNVFDFSVHKDSYVIVYKKSEKNVFKLQINSRNVVSCFEFEKLEKIEMKKKDNNFLFLITTDYVTNTYFGHTKIFFYSGTTRKLKEIYNLNPIHSFCFLNDGFAICYGDQPSNVSIYDYNCQEIKKFPRGVRNKMYFNLHENLVCFCGFNNLSGEIEIYGIQDLEIKAKLKELGASSVCWSPCGRYFCVATTKELRVDNKISVFDYFGRKIVEKNFEKLESCFWFGEKENFTALEKPKNMNLAVEKHYVPPNLRNSNYHQKLDKKHQILKKSKGKINNSMSKEDIIDKLNTIKELKKRLESGEKLNIENLNLISSETFYLNELNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW1</accession>
    <name>A0A4Q9LUW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1223p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001223">
        <property type="protein sequence ID" value="TBU11405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1223p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="8494" checksum="12AF5883A285224B" modified="2019-07-31" version="1" fragment="single">TLKLDRYEIDKETYGYLLRMVESMQQLENLTLIQVINDAKYYNFSLKHSNIKSLHLENNSLNNKIILEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV41</accession>
    <name>A0A4Q9LV41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1099p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001099">
        <property type="protein sequence ID" value="TBU11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV41"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1099p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="415" mass="48942" checksum="B3558C96E70E5B55" modified="2019-07-31" version="1">MHKHPRIDIRMIPIYFTAFVFFIINVKYIYSSDIYFPSKIEWEVDNRKQIYIKKKHIAIGSFAEVLLYEEINEKILIAVKAQPLELHAYARELEFYEKLSDENIIQKIFSFKQDGIGYIAFEYFPCTLLDIADEIKNITFIDLKIIHKQLLDALLYLEGEGVIHNNLKHNNVVVDKDLNIKIIDFGMACYIKDLYKVFKDENLDIEKLKEEYPHCSPERLIGADQNFKTDIYSWGYMLKTSSTLFVSQNQEFLYPDLIDIYEHALQVEVSARPSVDELIFHPFFDEIYNFLFCFNNYEDVEGNINNTLFDKIGNKILIRHSQFEFAIYCGCHNEKNDETVTRLLTTKIHSEKCTVCKTGFKISKYAKFKLEVSGQFFPIHILKMKYIKLIREDFLVFKSQIRLKSNPSIGLQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD5</accession>
    <name>A0A4Q9LVD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1120p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001120">
        <property type="protein sequence ID" value="TBU11605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1120p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="488" mass="57041" checksum="2690DBE3C0817AC6" modified="2019-07-31" version="1" fragment="single">SSFEEVQSKLLSGVIRLCHTRLNAKNLFFAINQHAISLINYHIRVLRLEPSDFFKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSFEEAQLGKLYNEVEKRKLYSKLYNARKNQLASVSDSSRWLKRGNIRPRNEALFSYIQERNVFWGADGGCQLLGTTRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNYRPDIFILDMKKNKITHIEVGITSHDSLQIVETEKLRKYDLLANEMGLIYKFGVEIIPYVMTWDGIVTKYHKSHLRRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEKSWERASMGVIMRAERHEEPTSPLKLAKREEDGINNINEESDLEEETILVKEEPIININKESNFEEESTVVKDVDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV9</accession>
    <name>A0A4Q9LVV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0768p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000768">
        <property type="protein sequence ID" value="TBU12406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0768p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="23738" checksum="50D9A6EE95BBEBB1" modified="2019-07-31" version="1">MLKLLRIFFTIQLSIFNLYMTINSVYLCAFYEDKEYDKSMLLDHLSCETDTHTNPSINSKNLMDESYMEFNKDIMETYIENQDTVSENALREEYNSEPITGESISDLLTDNSIDGSYIEHYDPSIETDRETHIENQDTRYKNVSKEGYNNENDTGKSISELSTDSIKSEILDQIYPESNLSSDISDERKRYKQENKIKWKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW04</accession>
    <name>A0A4Q9LW04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0592p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000592">
        <property type="protein sequence ID" value="TBU12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0592p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="446" mass="51358" checksum="D661CB793581F8B3" modified="2019-07-31" version="1" fragment="single">TINNTVLFPLDKCVLSCKYFISVNDFNILYNNLEIGVLEENIVIYILSRLSLFNEEDSLDDNSYSSNNRVTTNNSNNSYISNPINYPSINTSINTSVNNILSDNPINTSSNTSSNNNSISNTYPSNNNYPINNHISNTYPSNTSDNTYPININTLNNLRDTLYGLSYISKTIKNNLIRILRCCLDICITKHIFSIFKIIIRFIRCIEYNSLYGKSILRSINNSNNISRDRDNISRDRDNISRGNLYSNNLYGNLYGKNYNSVTLAIERLEKLCIPFSVLKEFTLKDLKSVLPVGYKEIYLLISKVPCFKGIVRRGERGRDHDYKDYKNYNNDYKDNMDTKNNNSHILTNNSNDILTGNDYSVYRVCVTLYYRKDEGVFESKNTENVHLCVTDGLDVCMLGYKYLRLVEGDNWCEVCVLNVKCSVLRFVVLCDRFNIEEEICDLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW18</accession>
    <name>A0A4Q9LW18_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0943p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000943">
        <property type="protein sequence ID" value="TBU12001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0943p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020262873" description="Macro domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="155"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="353" mass="40380" checksum="266094799EB7F221" modified="2019-07-31" version="1">MIIAFILIIGSLGLIQFIRTRSKDGSSSNDKKNTAQENEKKSDNTKKQMKTHEINVEEENPLPEEKNVPPKEEEEEEEEEEKKEEEKEEEKQEEKKQGEEKKEEEKKQEEEKQEEEITQEKLDKQFDLVNQFRGMFLSNISLPTLKTEFKAMIVNTLGLRVSNIKMNSKLKYKDLIKAFNLGLDKICIVNAANESYHIDGDGLNAGLTEFAKSNGGLNLEKNQWKNLTDKDNKPVRVPVLSGSYAISDFNNGIIIHGVGPKAWEVGKTPKEPKNLLEVKHRITDLYNNIYIEALKRGSVLIIFPKISGDIYANPGKDQSFTKTTYLNAVYSGIIDFLKKIKVEDRKILVFNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW86</accession>
    <name>A0A4Q9LW86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0994p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000994">
        <property type="protein sequence ID" value="TBU11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW86"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0994p0020"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="5">
        <location>
            <begin position="316"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="552" mass="63822" checksum="6F1E3953D6B57D8E" modified="2019-07-31" version="1">MYKIEEVRKIHNSDIKDVSVCDDYIATSSRDGSVKVTNINFSLNIERFPNCGYVNSLKLFKDSILSLFCGCQNGALVFYEDILNNENPIFFLGHNQNICSVDVYNKYVISSSWDCSVKIWDIISHTEVYNLIHEQTVWDSKFISETKFVTVCADKVIRIFEKSSVIQQFSYHVECIRSVFVNEKYIFSVSNAGKVIKSDFFGKILRTKNFKEFVYKISCNKNSFIFSGENGLVAVTDENFKNCFTIKVPSISIWCAVLSDEKIYAAASDGNLYVYSSLRTLNSEKNKISEAEISNRIINEKGGQSTQTGSPSEDKSFKLKDPNYKVVNGQLLNLVDNKWVVVGDVVENPTEKQFDHTFEVEVDGKHLPLSFNKDENVFNVADRFIKNHKLNSNYRDDIVAFINKNFKKNGEYFIYEGLNLEGIQKNICTFEGSEIIIENLKNPSHKNSEVVEEILLKMFGQIQKGQRFVILDCFKFFVAKYYSFDFSFLLDLDIFGQKEALAFTRLLVNLYFEPPFDLEVFHSKIKYFVDNGYIDEKTRDNYEKNRQIRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW88</accession>
    <name>A0A4Q9LW88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0562p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000562">
        <property type="protein sequence ID" value="TBU12998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0562p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020196774" evidence="2">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="311" mass="35642" checksum="E72FE4C302C21648" modified="2019-07-31" version="1">MNNIFLWFAAIFGSGSSINREVGSEINQLPNEESEKRTNKEDSLKSESSEMLSTENSTGGARVNYKKSNNLFSSEPFCHELNEGFSRLKTSEEKYINPNRNFSFPSQNHYSETSCHESNAQFTCPKSSPNHFRYDTDTKSLFDSSTYEYFRINHYSKKMSRSCSRSLFNERNYSSSLHKVVSGKIGKFHSDIPKKCIRDLFDKNLTKSEILPEKEQDCASNSESLNSKDASSPNKKPTQSMLLVDIFRRKHIQESSKLSEEKVLSQNPKLSALLSQPIQIDRHVHSKDSKQNTAIREYPLLTQILSRNESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB8</accession>
    <name>A0A4Q9LWB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0680p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000680">
        <property type="protein sequence ID" value="TBU12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0680p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="25007" checksum="2E036F7F0E5F63BB" modified="2019-07-31" version="1">MIISFEINPVVEVLKYSTVEGTDGEENGGPAKDLEHSGNANYTSCTRSKVSEMDGTNIFIDGNPNRSEDEIGVITTDVKPSYFLLQIGNGTMQQEPGTEVGSDSKADSMNSSDKICGCCGKKRICRINCYCCRSRGSSKPSECCTDSAFITHCTDEVVSCFRTCSDDVIKTIECCFNYPFKQIRRCCHHHSQCLESYRDDHLTCDDDCCEKLCSACCCICECLAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF9</accession>
    <name>A0A4Q9LWF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0686p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000686">
        <property type="protein sequence ID" value="TBU12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0686p0010"/>
    <dbReference type="OrthoDB" id="2195260at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="46131" checksum="A128D9ECA873839B" modified="2019-07-31" version="1">MDKITTTQKLILAYAVNIYGKSSDIHIKNYIFSKADFNVNLYYKWREIYIKLENESKENGYASVVEYCEDIRYKKMVEMYEENYRERIKLLEKKKFVFENEEKKNESKMFKRNVVSGILIENKSFNRECHLIDRNTIIVGGSIVAKEEGKNIEKDEKYCEWVSEATLHENLVSNSGKEILGENEVRSKVDLSENSGKIKLSNRYYWKMNDSERDFDDYLDKVAEKYENMNYSLHDVVPNVFRVEYPTTFAKDTKDVLDVLSKKAKSMEYQNKRNKVGIYIDDPALEELIRKVSGTKTISKDRTLWVGEFKLLLKSLEQNIKHDSLEKTKILKNGVISISSEVKLESGLTNSLFKVMMLLQNLIFDTKNNEIIKVCAEYKNYFYSFFDFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI7</accession>
    <name>A0A4Q9LWI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0531p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000531">
        <property type="protein sequence ID" value="TBU13103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0531p0030"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18760" checksum="F42849B776FBC2F1" modified="2019-07-31" version="1">MISANERLLTERNNLRKDRKYLFFGKPIKNEKKIDLLNWNCGFPGPLNDLYKNSYFQILLSFPKNYPLSPPKAFFKNFVYHPNVYTNGQVCLDILTPEKWKPTMNILQILLSIQHLLISPNIHSPANGTSCSVYMKNKFKYEEEVRNNIKKYHSKIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL1</accession>
    <name>A0A4Q9LWL1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0520p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000520">
        <property type="protein sequence ID" value="TBU13133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0520p0020"/>
    <dbReference type="OrthoDB" id="2188144at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22612" checksum="BA3D14D88A9FF300" modified="2019-07-31" version="1">MKLFFLFFFEYCFCWRNYIIIDPKTTETFYEQVKSDDLQLTIDMSLISKGTLNYRVRRPNMVLTDKDFKTATRGSAILKYSGAGPYAIDIFNPDDEPIYMVLGSYVDKEFEVDEDTAYIKSILEKLKSDLRNIYNQNMRIKEIKEENLRNLKKAKFKAYFLFVIALLYILVAYIKLRVVKSFFVLKKGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX16</accession>
    <name>A0A4Q9LX16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subunit TAF1 of transcription initiation factor TFIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0845p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000845">
        <property type="protein sequence ID" value="TBU12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX16"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0845p0010"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="805"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="906" mass="105116" checksum="92683E1F7324BF01" modified="2019-07-31" version="1">MNFNAFEDQNYNSSSSSEEEPYIPKANPSINESGPSNCNFIDLLVTPRKYQYKLKKYKYRRIPADLMNYEVDDLIRFKHTTSFPKTDTPVVSCLYTSTKNSVLKRYLKRKQLEKNKEKNVEKEQKIYVNHSFDIVEWEKDIIYDLEERTETKNKDILITEYVNNIFDEEKWEDQIVYDVEDLSSFKKYLTLGIEDPNLIFEKIDDKIKIKNKKKTKEVFIADKPIKSKYNISNDKYYNVETTTKNSLGHLGVQHSVPALKLNPRFYKTFLAKDELRNFHRPPFPLSKGFKVSLTNISEDSFQGTNIIKRATELTLKDQTKFALFEYSEEIPILMMNAGMVSLVTTFYRKNGPRDDFTPHDSSHITFLDMEDPSPFFGFGDVKPGTSLMAITNNLFKAPVFKHKSNDFICILEEKGPRNYIGYVRKITNLFCVGQTLPLEEVFSPHSRKHNVFCKNRLKVAAYRIFYNKENPEKKMKICDLDQLFPHFSEGSKRKWLKEYANCIKKGKDNIWVLKPGSSLLSEEDLRNLVTPENVCQYESMLAGERRLKDAGYEFQGNSEEEEDDDEIALSPWNLSRNFVNASNGRGMLQISGPGDPTGIGEGFSFLKYHFRKGTDVENKKMMSEIQLEYREDIERIWNKQIESLSSTLESIIDKHPGNSNQTVQNNISKNYEKSPKIEFPFDSQNFNSSKNNAIASSDNIPTSSSFLTIRRKYIINNEINYRDEILTDSRLIRAYLKEKKRVRTEEKRTGLRCGSCGQIGHMKTNKTCPNFIVTKKESKKSQESTIKGAKNTLSEMIVLCLNILFSIPSSEPFHRPVSTKKFTDYKNFVLNPIDLGTIKSKARQNKYLTFQSFISDVNLMLENCKKYNGADHSLTKMAENMVELSEKFYEEKKQEMLALEIVLNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD2</accession>
    <name>A0A4Q9LXD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0651p0010</name>
        <name evidence="4" type="ORF">CWI38_0298p0010</name>
        <name evidence="3" type="ORF">CWI38_0370p0010</name>
        <name evidence="2" type="ORF">CWI38_0458p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000651">
        <property type="protein sequence ID" value="TBU01691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000458">
        <property type="protein sequence ID" value="TBU13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000370">
        <property type="protein sequence ID" value="TBU13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000298">
        <property type="protein sequence ID" value="TBU16190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0651p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0298p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0370p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0458p0010"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU16190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="205" mass="22798" checksum="6A5C7CE7CA7A70C3" modified="2019-07-31" version="1">MSDISTHYGGSVLAIKGKSSIFIAADKRLGQGSITVNKDFVRIHRISPHLYISLTCFVPDAQVLLKNIIKNYNLFELKEGRKMEPQEFTKMVSFILYSKRGQPYYTEPVIAGVDSSGKPYIANMDQLGCISEPDDFVCAGTADKNLLGICEALCSKEMEDEELLVIGGQAFLNALDRDALSGWGGECYLANRDRVVRRSFKARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN1</accession>
    <name>A0A4Q9LXN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0535p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000535">
        <property type="protein sequence ID" value="TBU13087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0535p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="920" mass="109098" checksum="BD070B30108861D4" modified="2019-07-31" version="1">MIGNFIPCKGFKNLEKMTYDKENFGQHNLSTIIIRIFIQNYLVVFEDCVGIPTNGMLDIRDVNQHAIFLKKQFYRTHISLSLTTVKKLALYFSRAKMGTLDFLNLNFHVNNEIERQLSRIKLYNVINDEKECKLLHMKLKKKRQIWNQTLESKIKFNCSFDGVTTVEEPTMDLNKRKKGKNQINFETKNCSDIIFFSDEQRLKSSSEKNDVEFNFILLNNKSLPHKRKTHVFTYRKDNFVSFQILEDTLNSRLSPNQNGKIQCNINLAFFLKLTKDITAIPDKVNFDLLLGVFSILKYLKANYNKNLKEFIQALIFKTYLNLENNSSKIEFAYSKEYAMTNIWSTLDFYIKKEFILAHLKCYIIKYIYNEGNLILLKTNNEKFNTSIFEADIPYKSLLIKDYKIFMLLEKILKFPEIFNAFQILLNEMNLKSLILMCFTQDEISNNKSSFLIFSLNSFKSIMLYNVQSSSSFFLRNFIAASEHDLEFIKLENVNIPTNVLYLLLQQTKLKGLAIKNISIPGNLPLLDQYMVVSERFDYIKFQNVKINSIWWNTFFSKAIVHTLITSFNSISAEKYFIEEFNKVSNVKNFFHLEIIFYFAQISKEFCDSLCKFENLRTLKLRRYVLDKQTESNLFGAVMKMIRLENLTIQNYHISNTTQNDIFEKKGLKTLHIENEKFMKTIFKVEFKYNFESLNRICFKYITIERVCLIGIFELKGLEYLSFDHCYFEPFANLKFPNFRSRKLKFLYFNRTIIENINSVDFLNNLDCLEILDLSYSRSQLGYLISLNLMSNKTLRILLFEAGILGTRDLHRIKQMEFLEELDISYCEFSECHFFELSAECKFFNSLKVLNLWYVEINCEDLRYLLNFKNLTKISLTFYNHNHMSEKDCLFCIMQLIRSSNSRLEVSLNPNNIYYRYVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT7</accession>
    <name>A0A4Q9LXT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0506p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000506">
        <property type="protein sequence ID" value="TBU13196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0506p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="128" mass="14823" checksum="46EEF96206B9319D" modified="2019-07-31" version="1">MGKEKQPGSSSSQSLEDYSEDISGNGSGEKEYLRDATSYYQTCFLRNPREEKTFREKFSELRICGTSESSQDIRLETLDAEKNPDLSPKKESSDSSTNIYFFPASLNDYDNLFRDQFLISEYWIDDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY07</accession>
    <name>A0A4Q9LY07_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RuvB-like helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0358p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000358">
        <property type="protein sequence ID" value="TBU13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY07"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0358p0010"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB-like AAA-lid" evidence="6">
        <location>
            <begin position="181"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="28900" checksum="6C82AAADD1A19D23" modified="2019-07-31" version="1" fragment="single">GDVIQINKETGKVFKIGKSSFKKGDFDALGPDVKYVSCPDGELIKIKEDEKTVTLHEIDVINSRTQGYLALFSGESGEIRNEIREEVNKKVEEWVNEGKAEFITGILFIDEVHILDNEAFSFLNKISEDEFCPILILASNKEILKIDTQDGVEEQDIPKDFIDRALIVKTEEYTGKEIESIVKLRMEEENIAIDKESLKYLVDIASNTSLRYSLNLLTFSNARASKRNRSIILEDIKRVSDIFLDENRAISCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY36</accession>
    <name>A0A4Q9LY36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0350p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000350">
        <property type="protein sequence ID" value="TBU13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0350p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14505" checksum="CD6616F1A1772AC6" modified="2019-07-31" version="1">MNNLNSKRIILIVSLIASIAALAIIGYFVFRKKNEEDDSKKTENNTTNTEEKKRIGNKTGEKPKTEEPESEKSIKPKTEESESEKIIKPKKLQKPEHQLPEEVIKQLKEEQKKHQLSSKKGEVPPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT1</accession>
    <name>A0A4Q9LYT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0399p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000399">
        <property type="protein sequence ID" value="TBU13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0399p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="20337" checksum="5E449CAB3113E4C3" modified="2019-07-31" version="1">MPKSLLTIEIDYSFQSEYGNSDRIRTDTRHIFFDNGKKKTIHIYLRGITYHDSLQIIDTKKNIECGVEIIYYVMTWGGIVTKYLNPYLKRLQVFFNLTVEIIFFDLRRVLESRLNAEESSERASIDAIHDCEIYPQSVFVFLIHANGKKGSKKKTNTKLLKLKMLKKESKPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU0</accession>
    <name>A0A4Q9LYU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0395p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000395">
        <property type="protein sequence ID" value="TBU13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0395p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="341" mass="39494" checksum="29C88DA8D37AB9EC" modified="2019-07-31" version="1">MQKIYFLQSINQHTISLINYHIGVLRLEPAGFSKLDDAVRVALVNNKIYLRQRCKERLYLLITELGRGLHSVELQSEHILLQLLDGLENSKEISTKLATILKGFLKVKYRLIEEVTKKSLEEVQFAKLYNEIEKQKLHSKLYNARKNELKGNIRPRNEAVFCYIQDRNVFWGVDSVCRHCGKSGKTVDQIATAQKCQVMTIQSGIMKSHSMQKILHNKYADIRVDIRIETNVRIRNNILDIIILDKKKNKITLFELIYKISIEIIPYAIPTNCIVANNVIHTYKKQQIHMNTEGMSYQNQKRAANAPFKLSDDRGRGGSTLEELTININQKENIQRCENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW7</accession>
    <name>A0A4Q9LYW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0521p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000521">
        <property type="protein sequence ID" value="TBU13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0521p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="48235" checksum="52F093B3D7A38E50" modified="2019-07-31" version="1">MNLICFWFIRGLYFLEVLYAALIPFSNTNGRKKIEENYLHFLSGEIYTHYSYTDIEYLSSGGYGHILKATYIATRETVVIKVAKSNEYQISLTNEKSFLDKLNHLNIIKYIREIKINNKACLVFPFYENTLESAFLHKFFDDNEIRFILKQILDALRYMHNKGIIHNDIKPGNVLLQGKGCVKIIDFGISCNVNRPIKIFEGYGKSDIDQTFEFYSPEIRRNDLYNEKSDMWSLGYIVKYLKEKIRWSSLYEEMLKPSDYSNLLSCFLNNESDKRLSASTALMSNFFEGFYEFMYCFCKIKDQSFSTPGYTFFKLKNRIHINYYEYNIIIYCGCSIEAKNFCNEKIVQAKTKDISFFNSDNSQYFNFGVHCTYMIKINAAYYLLCELNVFELENLRVVFKYFIENILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX8</accession>
    <name>A0A4Q9LYX8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0562p0040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000562">
        <property type="protein sequence ID" value="TBU13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0562p0040"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="392"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="652"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="81229" checksum="3132995994A1E7C8" modified="2019-07-31" version="1">MSNTPDEKMLEALKSLSSKLSGLQKESALYKIKNLERRIEEKKKGLSEEKDKNIYASCDRKNIEAKINKEKNIVRAFEKLISVDGSLVEDLTAKIQTSEKKIFFLKKHLDKAPDIDEQRQKFSKTTGNVKIKPVSIECDPLYEAKMLDFYIDNELKASANINSNDEIIINLENNIEFEIVLVGKDNVFLGMVFFACERLVIHGKDEDVTFKFEEDAELKVKLSFERETKLIRKNAEIVCVYKDGHALENYYNIAPFYCCVCNNIASLFFESYRCYKCKFTCHKKCANYILFKCPCAKSIETEKHTIRYDIPHILQKQSQLGLNWCNHCGNRISSSESAFKCTKCNQHFHESCSSFVFKSCGMEYDLRIKMADFKPPVSEVQEKDSKIEISDFLLIKVLGRGSFGKVMLAKYKPESSIIALKILKKESIVNANDLVYLELERKILKLVSLPPHPFLMKMEYCFQDSKNIYFGTEFLAGGDLFHLVSKGKFSYQQIKLYACEILLGLEYLHSKNVIYRDMKLDNVLLCEDGHAKIADFGLCKDNIGPMTITHTYCGTPDTIAPEIILEGGYTKDVDWWSYGVVIYEMFETEPPFNGATNGEMCAAILEKEVEFNSDIPSVAKDLILKLLQKDPKKRLGSGENDANEIKSHPFFENVNWEDVYNRTIKPEFIPKSNLTDNFDSYFIEEPILITPTSSIRKYDEYFKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ60</accession>
    <name>A0A4Q9LZ60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5091 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0253p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000253">
        <property type="protein sequence ID" value="TBU18113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0253p0020"/>
    <dbReference type="OrthoDB" id="2193909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031527">
        <property type="entry name" value="DUF5091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17012">
        <property type="entry name" value="DUF5091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1013" mass="117241" checksum="0721E9E10F512C9D" modified="2019-07-31" version="1">MHLSVIISFCICSANIKTDKKSEKFNLTLVEKQYLDEKENNLDFMIEDPKLLCPRNTSTPKISPATSECSRESSYLDSINRPVKSPKKNIKNIERRRSLRSIPKTNIEPTLISSNDEKSDYDARHPTRNIRKRRFLSIRTPEKFNNRTTRLKENATYNLMDSILRRKEKKTKKAKCLGINFEPMTHGLENKNAMRNATEIPVPITENEIKLLKKNKFASHMFELTHSTPSDTTYYSCKEEDKTTSSEIPKSKTLCYFNESDVLKNKIKEFLYEFMNTLISYYKETNLNNLVVVALQSMRNSDLFSEAECNIYEIELKAKVITNQCENNESNYDFSENSLDYLKNLDELEEINEHGILKTLPQNSSSILNHSTAYNNNSSYNSTKNCQKSASKITRREDFKQTFKMKIKKIFHNSKIIIATIILSVILVSVSDFSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHYHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTGIKTDVKIRNNRPDIFILNKKKNKNTLIELGITSQDSLQIVETKKLRKHDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKKEKDGAKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKETTPLNIMMPPPPPVNEELMRKFQFILDNPSPQTIKSSFLMNSYIRMNMIYMSPISLGRFKYRMESLGLQSIQVNLHGLNFIFNGFNVFFRGSLKIMGSVLGNEKMQGNEKIIENGKILENNKMLGNSKIFCVELDFEPHVTNREGHKILVEIEKYLKGCDTIFFMTYFSDIDSEILHNPLSSGTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPTPPLKEEKREEDGEKNFNPKNKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA4</accession>
    <name>A0A4Q9LZA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdopterin/thiamine adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0087p0060</name>
        <name evidence="8" type="ORF">CWI38_0227p0060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000087">
        <property type="protein sequence ID" value="TBU04804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000227">
        <property type="protein sequence ID" value="TBU18867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0087p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0227p0060"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004281">
        <property type="entry name" value="PRK05690.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="283"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU04804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU18867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="372" mass="41789" checksum="ABFF5E20DB73DF71" modified="2019-07-31" version="1">MLYTSELTNSEIQRYSRQIILPEISVDGQIKIRNSKVLVVGLGGLGSPVVSYLATAGVGTLGLLDYDVVEFSNLQRQTIHSERTVSKDKTKSAFLHLKRLNSRITIREHSCMIGDDNANKIIAQYDIILDCCDNITSRYSINDNCKLLGKKYICASVLKWEGQIFVFADDGPCYRCLFPDPKNDNMLGCAEAGVLGPMCGVIGSLQAVEALKLILDSCKSFLLTYNGYENIFKKVEINQKSERCLVCTEKKIPPSNFGTCKNQIMRVSIDDKYKIKWKDFLASPTQYLLVDIRNKILYDMCHIQNSVNVPADTLDENNEIFKDKRKILFLCKKGISAQKVAAKFLEKGKNVFVVDGGLTKFKSEIDLNFPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA8</accession>
    <name>A0A4Q9LZA8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="15" type="ORF">CWI38_0203p0020</name>
        <name evidence="14" type="ORF">CWI38_0229p0010</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000229">
        <property type="protein sequence ID" value="TBU18742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000203">
        <property type="protein sequence ID" value="TBU19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0203p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0229p0010"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="2"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU18742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="978" mass="112746" checksum="67CEBFD220C3020C" modified="2019-07-31" version="1">MWTSQDLRRSFISFFKSHNHTHIPSSPIVPNDTSLLFTNSGMVQFKKIFLSTETNTFFNSLKRACSIQRCLRAGGKHNDLEDVGKDTYHHTYFEMLGNWSFNDYFKEKAIDLAYQYLVSLNIEMKNIYVTYYQGTDKIPTDHETKTLWLKYLPPERILPFEKENFWEMGDTGPCGPCTEIHYDRIGNRFVPELVNKDDPTVIEIWNIVFIEFERQNDNSLIILKNKSIDTGMGMERVLSILNNTFSNYMTDLFLPLFSVITEFSPINYIYKDSDCLEDVGCRVLADHGRTISVCIKEIRPSNEGRGYVLRRVIRRAIRYMKKMELKEGFLCELVRVASKITGVSISEEEMGVIMGEEVLFSRSLDKGLGVLEKVMESSKNKGGVISGSDIFLLYDTYGFPSDLTEIICKENNMVCDLKGFNDLFKEQREITRVRSKKCLTGRISTGVIEQLGGVIPTDDSFKYRCNGLRGSVLFTIENGLLIPYKETQEYDNENSCKETPCNQVLSKETINNNLIGLISDKTPFFSESGGQVSDIGKFYFMQKNSMKIDECVYADFRFLKKIFKEFEDTHKHIGELKIIDVQKYGSVVVHFGYLKGKLSEDVFMVYDGCRRECIRKNHSGTHLLNYFLRRVLFEEERNNLKEEIGFSKEEEKDSIDLKEGNNFNEKKDGKKADKKEQICGEIRNEEKILNNLNTIAFQMGSEVSEEKLRFDFSSLKNLTLENLKKVEFFVNSVINEELKVEKNTVKIENVGLETIRMKEEDYPGLVRKIEVKSKYGLISELCGGTHVDNTKEIGKFRILSEGSVSFSVRRIIAVTGESALERERKATEVLNLVREGKSVDTSILKELPLFERLEIENFIKENERIKLEERKKIVNFHIKNIQESDEEFIIYEVKCEDLEKSVILIAAGLVKNKKSGVVWGKNEKEIFCSFRCENAVEKTEIFLKECLNVKVGGKGRIANGKALLTDNWNLKKFNELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD5</accession>
    <name>A0A4Q9LZD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0222p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000222">
        <property type="protein sequence ID" value="TBU18894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0222p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="34653" checksum="EA4D6DAD9DF18819" modified="2019-07-31" version="1">MCIRGRNSEDIIVFWVLKIDLSVTYDDYLIVFLADNHSTMFPSQNEKANIFNWLPNWKAAGIDGIYDFFHEETYNSSQIFCVTKVCQQEVEGREIVDDNQLRAVRLPRSEKADIFDLDDAVRAVLKELEKVLHGSKFKSEHLVLKQLDSLKKLENTNKTQLYDLLANDLDLISKCDVKIILYVMTRDGIGTKYYISDLKRLQIPHNLDAYIQRIVMKKTVETISLKKQQELLTEPRFLKTYTFLKTSIKKITPIILKGGTALEEPTINIIEESDLEKETVMVKRGRRKYLKILKKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ9</accession>
    <name>A0A4Q9LZJ9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0316p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000316">
        <property type="protein sequence ID" value="TBU15130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0316p0030"/>
    <dbReference type="OrthoDB" id="2190070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="1">
        <location>
            <begin position="202"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="761" mass="91753" checksum="BE40D8E6EA1483E0" modified="2019-07-31" version="1">MNQNKLLDNFYLFKRKLEYNEYYIQEFKIHDICDPIDSSYSIITNEDLRIEFYEYVEVNGENNQKSGSAYILYKMGKEGFDFQFVESNETTGSFLIFDGKRYFFKKTNKKNNSEIGNFFPIFIESEKSLKFKNFYKHMESIDENFYEIELSIEKNNTLRSFIPFFLFENKKYFGNLSVHTFIFIKSADETNYGYYIRYINNNSEYFFVMITCINHHEFILFLINCYNLMIEYTDIQKTNLFETIMEIPIFNSSLFSVEYKRNKLIEIDKIQRDNFTLVFDNDFLIKVFSHIFMEERIVFLSKSAFQIYQVILFILKSLAPFEWDFLVVSPLPQQLSFLYESPFPFIFGIEKGAEDFNFESLDVIVIDLDEMCILRENKIRYLPFYDDLKYSLSTFEDKLSVMKRYFLIIENNIKILREKAFSKIYEKNEILKTELITFLEDSKRIFKEYEFFKNEDDFFNIFGGTRFFKRYYHKKNFDQICQYSVKMNENSAKLLFMPFVYIDSVNKKELEFDSIKVWIKMLNHFVKKAILFINERGYLKETAFLFFGKLSEANDLENLTFFLNFLKSLKIEIDSKMVDNLKATTDSKIIKNRFFEFFDLSNYRIIPLKICDCNILYTTNKKLIEFLKKNIKSEINWSSKNCRCGNNYSTSLFIYKLENSEIHNSLIVRLILPENIFLLIDFIILENVTKVELMEKEKDLFWNILFYFLYFDLPISTSKNCPEIYSNYEITENHWKSGERHHYDVFGSPSFLKDDDFDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS4</accession>
    <name>A0A4Q9LZS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0294p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="601" mass="71171" checksum="5CCAF49F4ADDEAFF" modified="2019-07-31" version="1">MILINLKNSLFYTPFSDEINSVSFFTTNATHRQNDKTTDNIKNKEIVLKHLNALNINLLNIHFPVKIPMVLQQQNISDVEDGLIQFIESVFESTDIFSFAQNMKANKNILWFILEIRNKYFRFQIEQNLSILVEKLYQINFETQTDPKPTNINSVLKYLKKFVLKKLFLKNKNFKAINEQKMKNEALLNESLKIFGQILTEFEFLILNFHFEGSFERIFLYLNIETSEIRKSCLCETGTNWVTGFFNNKSIFNILNEGGKRIHGASIGSIGIHLSNDEYESRYFTFCFQLNMYFDFVRREERMKVFETHFWDLFILKKSVFQDFSEQEITIFIIFFYQEKVSNIKLTDIYLQNDSLYFEIELDKTIKCKRILKEFSDKIFSISNDYHKFNLIFIDISFFRNSCVFDVKENFDVSWGQQKNDLSSIFSLKALKFNINLIFLRLLKLQIYNCQSANLRFKIILVEENILDKPALADVLREVLNKHVKDTRKHSKTIILDELTPSRINKLLSSTKNNYTFYDEYLDVIDSLIEELSAMFNELIRHKTIEGVFCDRKNDGSFDSQKVLSQIKNLKRSENLNTFKTSCFFFQKTNQSISNKKKIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M016</accession>
    <name>A0A4Q9M016_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0296p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000296">
        <property type="protein sequence ID" value="TBU16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M016"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M016"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0296p0040"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="37707" checksum="2D7B89F327D4B224" modified="2019-07-31" version="1">MFEINIEKFKESMLSILKEIEHTDTHCITRLLNIIDKTFIGAKSYRFYTFLNTLKELGHTIDDNSKVVGFCIEVLQTALIISDDIIDNSEIRRGHPCWYKLVGLNAHKDAIFLLLLIKKILKKYSLNSKSYTNLLKVYENVLLKTILGELHDVLPTQCTDFENIKKVYSIQNYKTMVIAKTAYYTIYLPIYMAYIYSDKVPPKNLLPFSEIMGIFMQFKDDYLNFFPEKTKKTSNDLQECKLTWYLSHLVEESKNENDKILILQYFQTKDENIVLPFIKKRLELFEEESEVFLSQARRYLDEETRKIYKFCIELFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M025</accession>
    <name>A0A4Q9M025_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0170p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000170">
        <property type="protein sequence ID" value="TBU19929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M025"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0170p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15939" checksum="27BC826CA9FC0A10" modified="2019-07-31" version="1">MLLDGVKSSIQYNTNTKLSSKEIFDFLREYIERLGELISILESEFEIEGFERNESISIIEVENELKRKGYYPAEFKLALISKSQVKDMQDQKINMFRPVSSISVASLQEFFHKFLDMYVSCINPRYLENIRIFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M064</accession>
    <name>A0A4Q9M064_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0437p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000437">
        <property type="protein sequence ID" value="TBU13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M064"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M064"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0437p0040"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="324" mass="36604" checksum="8DE402B675443F40" modified="2019-07-31" version="1">MEKRKIPISSKYINSSGINNFKNAIGIDIGVNIIKIAFLSIESNNLYFELISFKSKNLDLLNQMLMLENKDVKIYLTVGNFHKYIEKLKLDTKNIVIVAKIKAIYKGLECLLENNIGNFFLYEKNKKKTVKTKRPCLVIYIGTGVSIIKTDVDGYTNIASLPIGGATFFGLAKLFIKDVEFKEIFELLERGKNENVDLGFSDVFSNQDNLKETELDNSILISLGKLSVDQKSDFRNDDILSSILHMILNNIIYICLNEYERTNSSSLVFTGYFCTEDCIIKKISEITNKLSNQKVNPIFISNSGFISSIGAIISGINGYNERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M081</accession>
    <name>A0A4Q9M081_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0148p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M081"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8451" checksum="EB9EA8EF984BBE0D" modified="2019-07-31" version="1">MLKRIQIPINIEASQQFLLINEETITPLKKVNIQEDGVKKENPKNILLFIFDNVATVKESTINRKENSALGEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M084</accession>
    <name>A0A4Q9M084_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0432p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000432">
        <property type="protein sequence ID" value="TBU13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M084"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0432p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="571" mass="65318" checksum="EB52ADFDD2F78876" modified="2019-07-31" version="1">MKIDISVGPEKIMSKKILREILQGDSLSPLLFVLFMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSILSAMTDEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRAERLYYTRLNAKNSFSAINQHAISLINYHIGVLRLEPADFSKLYDAMRAVLVKNKIHFRPGCKESLYLPRTELGRGLYGVELRSEAMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKKGNIRPRNQAVFCYIRDRNVFWGADGICQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRSKFKSLKRIRSHSVQEILDNEYAEIRADTRIKIRCNIPDIYILDKKKNKITLIEKGITSQDSLQIVETEKLRKYDLLANELIILNLMTWDSIAYIQSIVLKKTVETISFDRRRGLESGLNAEESWIQLSLKEAKNDEDGVKEIKTKNNKPLISKGGTSLVEPTIKNNAESDLEEETMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A0</accession>
    <name>A0A4Q9M0A0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0061p0030</name>
        <name evidence="2" type="ORF">CWI38_0159p0050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0A0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0050"/>
    <dbReference type="OrthoDB" id="6410759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12661" checksum="164E4B2096BED441" modified="2019-07-31" version="1">MDNSDFKKEDLIKLRDCGHIQMEFEQLELQQFWCTQLEGYPQLAKEALKFFLLVATSYLCEISFLPLLHIKPARKIAKMQVMTYVCLFQKRASLYKYYNQQQQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D9</accession>
    <name>A0A4Q9M0D9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0144p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0D9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0030"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="182"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="619" mass="71855" checksum="8DF705DC388FE600" modified="2019-07-31" version="1">MKECVMKEIYASIQKYDNIIVTGGTGSGKSTKLPQILYKSGNVIITQPRRVSTVTLAKRISMELKSKIGETVGYKIRFESIVSKNTKIFCVTEGILLKEIETDMLLSNYDYFVLDEIHERTVLIDILLSYLKYLQSIRKIKIILVSATGEIEMLSDYLDFCPVYNILDKKFPIKIIYNDLLKVEDIIMKENKNTLVFLPGINEIEEYSKKLKNLDAEIFILHSTLRERNFEVFKTTETRKIILSTNIAETSITLPNIECIIDTGMCKEKIYFEDDDLESLETIFISKDSAIQRTGRTGRTCPGICYRLYTFDSFQSFIDNRKPEIQRIELSNFILKIMHLIKVSKIEYLKLPASPSLKSLNNSISKLLVLGFIEENFTSKEANFYEKKAYISQKGIISNIWNIDICSFLKRYNLTQLGNFTSIIPFDFLLSKIISEGIKYNLAYESVMLASILTSEIFFNINLIEISSTFISAPNNDFDLIIKLFYRILKSENKIGMCNQLNISYLTFRYTEKIFKQTLKLLKISEKKIETNINNKFTIKNVIINSLYINTVQKIRNSLFYQRILYGNEDQYLLSTNSTVKNCNYLIFYELRTKKKVMNFNIEITNTDLQNIKAKLHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K7</accession>
    <name>A0A4Q9M0K7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1253p0010</name>
        <name evidence="2" type="ORF">CWI38_0124p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001253">
        <property type="protein sequence ID" value="TBT99682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000124">
        <property type="protein sequence ID" value="TBU20149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1253p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0124p0010"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9645" checksum="CBFE55AF55883BE7" modified="2019-07-31" version="1">MENIDISFCNIKYLDFPKTEYFPLNLTKLYLRSNLVRKTDLSILSRFEMMKILDLSLNEIKGGSLLILENTPLVSTLEALLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M106</accession>
    <name>A0A4Q9M106_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0090p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000090">
        <property type="protein sequence ID" value="TBU20319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M106"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M106"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0090p0050"/>
    <dbReference type="OrthoDB" id="2195459at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15008" checksum="4A7FD9B748F7116C" modified="2019-07-31" version="1">MKKIRLRSGTLPLLPDNKIILISSTKRKEFVLPKGGIEGIETPIQTALRETLEEAGVTGVISNIEPFYKDSTCQWYLLNVNHIQTNWEEKNKRKRIFLSIKEILENKDKLIYTKTIKVIRKAIEKGIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D9</accession>
    <name>A0A4Q9M1D9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0058p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000058">
        <property type="protein sequence ID" value="TBU20520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0058p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="529" mass="62914" checksum="48C111AE91A2BE0E" modified="2019-07-31" version="1">MNAEAYIRSIVLNKTVETIYFDRRRGIQHHLLLLQEARCINSHTPFKAIHAKNDLPLISVRSTTVVKSTINMSKESDLKRGSEIVVSGVIKTDYDDFSGDKMFFYIESHETQIKISLIHRILDIVKRGDSISKLLYDGKNTFYTLTLGHENIEKNDFEVVKISSSDNKARICEKYCLARSETSSDSFLSKLKEKIYHVKNFAIKNKNDYTRLYIFCQEIIEYEKYLFKKMKGKEILERSKVLDINHGLYLIETDSRYTVLSEVFFFFNLYREKISNKIRQNNFIYVSFLLRIFALQIIKVLPKDQDDFESRYKSKNNLDNLIFYFEIFKLRKIFYNILLGFENFNRKAYFYQLLNILDFRQKLSLENYEVEEYLLFKSQLNTMFFLNLNDVRYRKIIVLIGIVCYAKAVNLNDLNIYLLRLTFSNLTNIFSILKNLSHVFLDKKHNIFYASLRESCERIYIITRKEKIDKYSKAGESFPNPVSIEKYIWEFLLKLEQAIFKNYETNELNMEITDDLIEKLNTRISLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F4</accession>
    <name>A0A4Q9M1F4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0199p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000199">
        <property type="protein sequence ID" value="TBU19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0199p0010"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16961" checksum="1703CEDC746B135F" modified="2019-07-31" version="1">MMALIAQKYYGIPKEYVKEYEKRLINKTSKLVRYSLKFLFDNIGVPVAIQSDNGQVERVNQTIKRWLAKKLHETGGRSWIEHLNNVILTPTNTIIPDDLASNSKIRSDVAKPYKNYRERIIESKNSNKLKRDFSIGHQVLIKKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K9</accession>
    <name>A0A4Q9M1K9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0249p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000249">
        <property type="protein sequence ID" value="TBU18228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0249p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17215" checksum="AE0575F18811BEE8" modified="2019-07-31" version="1">MVYKMKNIGVPCLMIMLIRRIRTLSVKYYFDDYILQTVSGYKNLLYSENEKDMKAIQIILFISTCIAFNIPLIPGYDFPVGKSSLVEKRKNQYESPSKLIETLDKSNLFGPSRSIFATSEFPGGTMERSFPRGYTNPLPVPDERYHLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U4</accession>
    <name>A0A4Q9M1U4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase/endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0032p0090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1U4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0090"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020626463" evidence="6">
        <location>
            <begin position="18"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="226"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="8">
        <location>
            <begin position="617"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="747" mass="88130" checksum="67166B11EF213C5A" modified="2019-07-31" version="1">MLLFVQLFACGLLIIETQDGFLHVLDKETMKVTTLLNINHIINEDSNQHTGLTYFTPNSSLNLTEYNNKYSKEENLNLEFENTKNILLKEDQEKVLPSHKKFIDSLFLDRNGYFFYKENGKLVSMNLSIVEIIESPKIVRNTVLVSDKNVTIHKIFINNIEIHVFIVNVTITAIDALSYYNRKIFFSYIYYPFTSVCEDLIFQRNSVFLKTKFQTVEFNSNIVGAYMIKKHYNNYYFSKIFTVSKMALPYIKSNRRSKLVYLLSFVVIVLTIIIFRSKRNVVNIKEIIADRKNYVVRKGFFDKTVVIVKVYKKGDIRSENEVNILRKNQSLNIVGYFYQEKRRWSTLIVTEYCKSLYDCNNFNCLRRLSCDILNGIMFLHSKNISHLNLSFQSVCIRNDGCGILTDFEDARYLDSNLSFLEHEIGSKNFRSNEIILFNHKIQNLNSQMAFKADIFGLGIILYFLITRKHPFDLNVNGIPLENMYFSDDEKSDSPSNETTGDQKNNKSLPNKKPDSPPYEDKVSNKKHKSKNKNLEKVESKNSTNEIKKINPIETSLCKNIIKDTENDFEMNILNDKYKLVYLNDHNLHDLVCHCLKLHYMDRPDIFNVGCHPYFWDNEKKFNFLANLSDILENKTEESKRVFLRLERNKRKVFNKSWILYLDKRIEEELNIFRNYNFSTLKGLLRAIRNKGRHYKELPSEIKQLYISFPEGYVDYYVKRFPSLLMTCYYSAKCISTEELLKDFYCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M259</accession>
    <name>A0A4Q9M259_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0023p0130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M259"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0130"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11553" checksum="06D545DDC5A23C9F" modified="2019-07-31" version="1">MNNNQNLQNFLEIKDIKFKAYLYESESPMGVIMRAEMHWKPTPPLKEASREQECAKNLKTKNNTPLISEGGTTLKEPTININEESDLEEEATVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M333</accession>
    <name>A0A4Q9M333_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0130p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000130">
        <property type="protein sequence ID" value="TBU20112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M333"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0130p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="324" mass="37824" checksum="3BA649B302E5B48F" modified="2019-07-31" version="1">MYKQDRKSNQTLSSFEELYDAIRSVLVKNNMNLHPGCKERFYLPRTELGRYLIIASTTLRSSGKSKEISTRWASILKYRLVEEVPKKNLEEAQVKKLYNKIEKQKQRQKLDSKLYNAKKMSMPRNEATVDHLETRCEKMLSHEYTRPHNEMVGCLHLLLLNRYKSHSIQEFLHNEYAEIRIKRIISKQLELGITSQDSPQIYGLLTNDVEIISYVMTWDGIVTNTIKISLDVEGYLQSIVLKKTVETIFFDRRRELDSGSNAEGSWYRASRGVIKRAEMHEEPTLPLKQASRGEDFLEEPTINICEESEIEEETVVAKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3C1</accession>
    <name>A0A4Q9M3C1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0032p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3C1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3C1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0020"/>
    <dbReference type="OrthoDB" id="2188923at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="875" mass="101697" checksum="AEC713F4E4F394F3" modified="2019-07-31" version="1">MNISILYKKNILGVCIQDMKDLFIVQDIYDTHECDILKDIIHTFDIQKCFYSLDLKECQIEFEMIVTKTYENLSVKKHLEQFIEKDKYKLSISCLSSLLIFFNCPEIIKEIIADNKKVSCENRFFVGKKVKTVETIKDERQNNFRMCKLITSIGVYNIHLLDLRETLFLSQSTMKSLYLLKEKRHPNINISTKKDFSVIEKIDFTQTTMGKSLLKLWVNFPLLNIKKINERREIIDYIINNSLQTKTTQFLKMCVCLEKNNNNFYQKNKKSYFFKLRKFLMASYEITKLFKNVFQHDTDFISDLIYEIDSKLDLNAKINSVSNKDRKNINKTNSNDSILIPFDKSKGNNILNEFHTFLDDDSYIGKTNINFNDIDDKNVFIIKEGIIEHLDTLKKTFKELPEYLDCIAKKVSNEKNITVSIIYYPQIGYLIETKSNIEEWICKFKIKENYYYKNEFMNDLDSELGDILTQIYDIELEILNSIRNKIVKERRKLDSLIDYIAIVDCINSLATSAIKYNLKKSDIIDKNIFEFKDLRCILNFDFYGFDFTLDSNCILTGPNSSGKSSLLRTIGISIILNQIGSFIPCKQASMKLFDKIFTKMASNESLNCNRSAFASDMSLVREALNYGSSDSIFLIDELGKGTNIIDGTALFLSICKNSRDILVISTTHLMGWLIDNFNENKTIEVLNTKETPSNASDQNTFNTKYAVSSDENSKSTSIEALNEIFDCKRTKIETENNRNTSDSSSQIISKDKEFNNLELSYINESACFKNKNIFITKSKDDLSGILIQIFDNYCFKMLEKQISSKKYTIKDGICTESLGLELMHKFNYPASFYDECIELKKKLSQKYFKNLNMQENDNNWAVEIINDVIFNAKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3D4</accession>
    <name>A0A4Q9M3D4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0057p0080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3D4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3D4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0080"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="90"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="215" mass="24837" checksum="BEF6BB65F3C2F479" modified="2019-07-31" version="1">MPKVKLIKETKKEETDPQTLTHRSQRKELEQLVSTRKILLMNRMRVPPAINQFSTFLDPDTFSEILSLFKKYRPETQKEKSDRLSNKDWKKQPKPILVKCGIKHVTQLIENKKAKFVLIACDVDPLEIVIHLPTLCKKMNIPYAIVKGKELLGSVVNQKNATSLLLCDVRPEDTKTLNKFIEKSNNMFSNRYEDIMKKWGSVGGVEEKEEAVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M433</accession>
    <name>A0A4Q9M433_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0083p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M433"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50840" checksum="A684F2ADCF655E7E" modified="2019-07-31" version="1">MQKIYFLQSINQHTISLINYHIGVLRLEPAGFSKLDDAVRTVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKTAISKVENNNKTHLAPIKGFLKVKYRLVEELVSVSDSSRWLNRGNIRPRNEAVCDIIYITKYYIFILYFEIEKRGAVMNKIYKDNFSNNNSLLYNNRGMDRNVFWGADGMCQHCNKSGKTVDHLATRCEKIIGHDYTRRNNEVVRCIHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEYDLLANDVEIIPYVMTWDKIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLHSEESWERASIGVIMRAEMHEEQTSPLKGEKREEDDAKNFKPKSKAPFISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M474</accession>
    <name>A0A4Q9M474_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0087p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M474"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="5793" checksum="8F1DAA41F93DC5FE" modified="2019-07-31" version="1">MAICKNLLIIIIIVVVVIFLTGGFGATYYVVNHPREGAGGGGSGGGDSGGDKAAAGGGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M490</accession>
    <name>A0A4Q9M490_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0070p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000070">
        <property type="protein sequence ID" value="TBU20441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0070p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11948" checksum="C20D77B5E8AFC5C0" modified="2019-07-31" version="1">MTLLLKKYLTLLCKLNIDFLTEKYIFRQKIGVMDKNIIFENEIETEIFPIVKNNDIYVNPSANQQKLSQKSFNQNLDMENNLHNSNRESIFGNQKRYLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4K6</accession>
    <name>A0A4Q9M4K6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4K6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="23285" checksum="40BEF31E53BD8F16" modified="2019-07-31" version="1">MENEIFISESIKNFEFWPNANDCYSIFSKLIGMMIDLQEIYFYKTNFIKLNRFVNQIFYITELILLDINKMIDSLQHLAKNEKFDFEATSKDEENLKLSSSPLNNLFRSYEMWAIKKLIIRDFSIDNLDVKAFSNLLKLKEIKVYRINFQNISFSEFFCAKQEYKIKIMTLDGLNISEKDLIFIANLKKIEDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4V5</accession>
    <name>A0A4Q9M4V5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0022p0120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4V5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4V5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0120"/>
    <dbReference type="OrthoDB" id="2195735at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="25122" checksum="A97178DCDDE4335E" modified="2019-07-31" version="1">MLSFEDITNFIKYNQEYFEQNEIQEIEKFLINAKTRKEEIRKENPNKEKANEYKEIGNKEFKNGNYEESIRYYTLGIEENPLNEIIFSNRAASYAKIGKNEEGIEDCHRALNINPSFYKAYIRLGSFYFDTDKNKAIEFYQKALEFDPENEICKSQINLLSSPKEESPNDFNINNSYFTEMLKNPEFKRVYDELKGKSPDELSDILKNLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4X6</accession>
    <name>A0A4Q9M4X6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0043p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4X6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="22399" checksum="0708F3671C4B24F6" modified="2019-07-31" version="1">MYNSKRFLTGCSGTPCGVERYFLRIPDLKRYNSPKREKTTDIEEIKYISFKKIVIKIIRYIENIEMRHNSLKPGLKNMRKLNFLKLEIKKIVIRIAARIRFLKRKQILLNIQITEFSYLKTRLCSYTFPPVCAINKRFYFQSEALWKVRQRYDEFCSAYMVYTPISQNHVDTKPKQNNKYSEKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M537</accession>
    <name>A0A4Q9M537_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0034p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M537"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="534" mass="63231" checksum="A2E67EA407086ABC" modified="2019-07-31" version="1">MIAVTKVIFLFSEEDHDFDSLKVNSLTNENCYVGKKYEKDTMTERQTKKFSLKERYNIFVVENIEKYPIIFKRITEKVDKTQSDIVIVLKNTKYSEFKIFDNFLKTCYLPQETFSINHFVLILYFLDSLKVVFNINFTKIINCLFYNLNIFCKNEMNIQMKFWIDFLVSNEDSLNFFNMVFDIYLAYFGINNAYILNDYINFESYFLFETYDFLLTNKKYRILKIDETFLNIILAREIDNFFITVFLALFNAEVIFIEKYDLLDAKSLDKCLFMITNSVDAIVFIDISIKDSVISFINSNNIFKKITNLYFYCYSFTEITDVLNKSLGIKKVFLVDWLENQNLQYLSSESSESIDKLKLLINEKSLNIGIIEKNFSEDSELKSPEYYLIENFNQNKHVLLQKDKMSKIKVLARFNFKYSYCSCFGFLTDKNEVKYLSIEYTNAKIENLCTLKNHVIMNIKSLKIFQSEVTFEALINIVDFPYIKELELNKVEIIQIIENFETDKNNQSLLNLKIIAPKISMKTKSMIIYIVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5E8</accession>
    <name>A0A4Q9M5E8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0022p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5E8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0060"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="349" mass="41289" checksum="344FA14462C287F5" modified="2019-07-31" version="1">MFDQDLKKYEEIERKRRISVNKEIEILLFKRKQTNIKIEEEIRNLSKEITNYDDNSNNIIDYNIDQRIEDDNIDCTIDNKYIKDISIALEQNTILATNINTTDTSITNIPTKITTTISNITNIPFTDELVRKLILTEKYKEIEEKIKNEKSKISKNIYINLKININKRLSQVSQSKDHTIKIYKSLSQITYPYLFIECFVLKLLEQGKLQVSIHFLSYQSYSLLLSLFLNNSLFGNELLEYFRVILFTQESTKSSLKGMYSIYFGVIHLNKMYQEAWFFIASLLNIIPSEPSLYVLESFLIILGEDLFKMYKYSFITMLKYVKEEYLTRITNDALKTRIETCIRNIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX79</accession>
    <name>A0A4V2JX79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1559p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001559">
        <property type="protein sequence ID" value="TBU10772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX79"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1559p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="857" mass="99771" checksum="7F3BD5C61740975C" modified="2019-07-31" version="1" fragment="single">ANILDSKEQITPLTTHEVVKPIHLPKKANILDSKEQITPLTTHEVVKHEKHIHPPKNPNILHSKPSSLFLKTKIITLIPLKSLTNTSIPTKNIPLFRLFIRPLKYKEIPTLHKIRDNRKEEFKQEKLECPHLSTVYDLLLVNDISHFESPHFYDKSNFLKTMNRELNNESEKNQNNELDKTLNTDLRNINPRNNKDMSHSSPTNTRNNTNTNISDTYNILNTFLSNKYTALQSSINTDTLLSLCLSLSNTKVRNNIIFKYLNTFLSTKNPYFFIILAGILENENITKNQLFNFSPPNLLYENSQKYFMDVFHTKNVFFIHFFVQKVLQLNRITGIYILTVYTLLTLNECNSVDSMDSRVGIMDRNSTRLEIDNIMYNKQSNTPSDNQSNTQSNMFSLFPFLKYFCYNFYTLKFLFHLEIFIKKSFNDINIFTVPNLNPDSHLNSISYLNSIPNQNYNFDLNTLKYLYLQVCIEGNRKDIGGLYYNECKNIFTGNKLIYLDNYYKEKGWMPFFGFRSVVDRSISRIVGIEENKDEKKGKELVNINEGLRNENVNEGSINENVNEGSINENVTERQLKENSNKELNFQIIKEEEIKEFDFTKEEIQENTKEVKEIKFTRKEELKQEGLQEQIQEVFHENMNQENINQENINHEKNHENTQPSLSSSFYINKQYAQSFADFFTDEHTSEEVKTMDDSNITNKYFNFEDEPSNNIQSNKQNNKQSLLQSKTENEGKSGFFSFFNVFNRKKVQKVKLTGQSDFKYDPVSKKWVFSGNVSGGVSEVDKKNSKDKKDSKDKSDSKEKSDVAKKVESKEPLPPTLQPTLQPIIPPSTTKQSSSKKMDGRISSRYVISKGKPKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF3</accession>
    <name>A0A4V2JXF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1121p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001121">
        <property type="protein sequence ID" value="TBU11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1121p0010"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20579" checksum="7387095944EE4B9F" modified="2019-07-31" version="1" fragment="single">MNTLQSLIQNKDHKAISLLPSPTYDVYKGVACIHMEKYNEALNFITKNSYEYAYCLYKLKNYKKSIRILKKLENTPKVMILLSQCLYYLGYYNGAYEILSGLSSDDEIVVNISAIKSIAIYSSRGSINERLGLASKDIFNSKFIDFSRYKFTDTECHKEYLFNQTFEYMNDKEEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH9</accession>
    <name>A0A4V2JXH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1016p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001016">
        <property type="protein sequence ID" value="TBU11842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1016p0020"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12888" checksum="3E02FBBC325F3468" modified="2019-07-31" version="1">MVLVEYMVLVEYKVLVEYMVLVEYMVLVEYMVLVENKGEVAEYMVLVQYKVLVEYKVLVEYKVLIENKGEVVEYMVLVENKGELVEYMVLVENKGELVEYMVLVENKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS5</accession>
    <name>A0A4V2JXS5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0575p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000575">
        <property type="protein sequence ID" value="TBU12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0575p0010"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="127"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="593" mass="69332" checksum="15929F31442C3E1E" modified="2019-07-31" version="1">MEFEQEKVERLLKKNFFISPSAHIYGGVSGLYDYGPYGCPLKNNFINFWRKFFIIEEMMYELDTTILTPYEVLKASGHVDKFCDLLVFDKVTGEFYRADHLLKQEFSKMEETDQIKRIIDNLDCLNIKECDGIIKAYEIKSPNNNELGNTTYFNLMFSTFIGPKTQNMAFLRPETAQGQFINFKKLYELNNSKLPFASASIGKVFRNEISPRSGLLRVREFEQAEIEYFVHPKEKDHPKFQTISDLKINLHFSKENEIQKTEKMSIGDAVKNKIINNQSLGYFIGRTKIFLEKIGINEEYLRFRQHKKDEMAHYACDCWDAEIYCSYGWIECVGIADRSCYDLTQHQIASKTNLNAHIQYSEPKCVEFWKPEIDKKAIASILKEKTGDFLKELNNLPEEFISKNLKNNILTFQNIEIKFIRNKKNIYVEEFVPGVIEPSFGIGRIIYCLCEHSFYTRKEDEERGVMKFVPRMAPLKVVITLLKQTPSLQLLLTNLKEEMSKNDISFSINTRNVSIGRKYASNDEIGVPFFITIDLQSMSDKKATIRERDTMEQIRVPLEKIPILIQQLCNNNVKWENLKNEYGLFVFKEEQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF0</accession>
    <name>A0A4V2JYF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0014p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8552" checksum="E962C021C224D061" modified="2019-07-31" version="1">MTLLTIFFARRRGLESYTRVSLHFLKQPNFEENGSIYFKAKNNISIASDEGNTLEEPTKNINEDSDLEQEKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUC3</accession>
    <name>A0A4Q9KUC3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1862p0010</name>
        <name evidence="9" type="ORF">CWI38_1068p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001862">
        <property type="protein sequence ID" value="TBT98185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001068">
        <property type="protein sequence ID" value="TBU11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUC3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KUC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1862p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1068p0020"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT98185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="200" mass="23396" checksum="8F065FCC2D41D51C" modified="2019-07-31" version="1">MGITTNIVLVVLFTEISLFTILLSPFTSLKKSFVNVTNSLTFAIRHILMAIYSMIFLLFIDSLIKILKTKNEMPYTNYNSEISHTYYSKNVYLSSFTLFLAIVYKRFTILLLNLYKEEEKAEVLKKQAINQKSYVSELVSKNEEKEEIIKKLYNEIESKSKEVKCSEALVKQAKNNQDEYLKLLEKYNKLVDLVDNKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYC9</accession>
    <name>A0A4Q9KYC9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1148p0020</name>
        <name evidence="13" type="ORF">CWI38_0695p0030</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001148">
        <property type="protein sequence ID" value="TBT99992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000695">
        <property type="protein sequence ID" value="TBU12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYC9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KYC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1148p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0695p0030"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="10">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT99992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="234" mass="27202" checksum="B5AF6A4479EC9FEF" modified="2019-07-31" version="1">MRLETKNSEITVWLVKVPNFLAERLHELEGDIDIGELEITSATENEPASVNIKFSEKVCGSGFPTSFHLDRSEVDKQMYMLKSEKDTSGIEGKVTTECFVRPVINEEYILYRKTRNEITSGPKRMTQVIDFNKDGRIGERIGSISELETMARKRKKMLMDKKRERLDKSHVMDMLFNAFEKHKFWTVKDLADFTGQPVAYIQELISEIGMLNKKDHKNTYELKPEYSYGRDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZK2</accession>
    <name>A0A4Q9KZK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1092p0010</name>
        <name evidence="3" type="ORF">CWI38_0236p0040</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001092">
        <property type="protein sequence ID" value="TBU00166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1092p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0040"/>
    <dbReference type="OrthoDB" id="2191630at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="130" mass="15672" checksum="F636BEFCF9A9E05B" modified="2019-07-31" version="1">MRHKKGLLTKWLLLISISRFIIIIKEIYDNYNTKPTIENKRTLFIFLSFILGLTRIISIRKITHSYVYLTITLSFLFEGFLYIFERFKESVGVIRVSLEILIALFSFFWMIFLYPYYLVDSNNFIEEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4K5</accession>
    <name>A0A4Q9L4K5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0567p0020</name>
        <name evidence="4" type="ORF">CWI38_0019p0080</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000567">
        <property type="protein sequence ID" value="TBU02055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4K5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4K5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0567p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0080"/>
    <dbReference type="OrthoDB" id="2196078at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="551" mass="61623" checksum="D1C76A7968066130" modified="2019-07-31" version="1">MKAKEETKKENKRKKMCKEINCKQIIMSRRKQAENECGCDEYECFKWNTEDNNIIIRANDNYERNNTERNVDLKFGPKSAMICENSDKITSLEVSFVKEFAKIYKFSKLRSGLRSNTNRSMFLMYLIVMFSGFGKAATADFGHYFGHGGISHGDSGHYGYDIHGGMGGVFANHRGKNMHKGDSGLNGILFTRDVVHHGDGSIFVSMNEGTGGPIVGVPESGLTLDQIHEGINRAINNAHDASIAKKDAEKRAEELKASIAQEQAEQQAEEAARLKELDDKAAMIEHEKPEVLGKRTIPIVNFTEESIPLMHHMRELSKRIDDIRETEAQNILAQQMITRLDDMTDAVPKRNVISDNPDFYKEFEDAGNVDNFKFHVPVTDNRGSFYIKSDETGDHSHSVPMRSHKSPDGHSHWVDHGELDKPQHSFPISPEELMDIPGAAPNENHSNAGGSHNSSHPPVLNSFKFPDSSKHETPHSKPKTSTNPKPENKPPGKERSNSYTKGPRNTQPGPEFPSFDFSNPVLNPLKIPPSSPMHSKSPLFGSQLTKSFGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6S3</accession>
    <name>A0A4Q9L6S3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0247p0030</name>
        <name evidence="8" type="ORF">CWI37_0312p0030</name>
        <name evidence="10" type="ORF">CWI38_0518p0040</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000312">
        <property type="protein sequence ID" value="TBU03333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000247">
        <property type="protein sequence ID" value="TBU03706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000518">
        <property type="protein sequence ID" value="TBU13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6S3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L6S3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0247p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0312p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0518p0040"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU03706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="153" mass="17388" checksum="E9BBC965091DC632" modified="2019-07-31" version="1">MQIFVSIPNLNTEVLAVNDNMKIVDIKRIIEERTSIPVEEQNIVSCNRYLSNESTLSFYNITEMCILTVLFKLVGGGKKKKKKNYTTPKKVKEARKKTKLGCLTQFKINKDGTCDVLRKDCPSCGPGIFMSERESEHKCGKCHTVVPRKGLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6U7</accession>
    <name>A0A4Q9L6U7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0308p0020</name>
        <name evidence="9" type="ORF">CWI38_0824p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000308">
        <property type="protein sequence ID" value="TBU03357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000824">
        <property type="protein sequence ID" value="TBU12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6U7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L6U7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0308p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0824p0020"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="176" mass="20092" checksum="8CE33F077AD71E1D" modified="2019-07-31" version="1">MRNLKSEEQEKVFKKLKKFIGENTEKLLKGHRLFLHKQKVFHVSDELEKNASSIPKDDLVSIGSCLGRFTKSMHFKLTITSLHVLSKYALHKVWLKNSAEMNFLYANNILKSHILKMSEDVPINANVFVFNQNDLPLGFGVTAKGSTHLSNIEGNTLVVLHQADTGEYIRDEERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA05</accession>
    <name>A0A4Q9LA05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0115p0020</name>
        <name evidence="2" type="ORF">CWI38_0191p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000115">
        <property type="protein sequence ID" value="TBU04589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000191">
        <property type="protein sequence ID" value="TBU19830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0115p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0191p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="394" mass="46197" checksum="233D9FD4D6BB21C3" modified="2019-07-31" version="1">MIFNVFATIISAATYTKNPKSSISDCLKNPNQNIDLHLTLNSDSSNDFMEMDGSIHYKQTNCCSINQNISDCVGDEPIQVLGSNKSSNDTDLRTFRPNLDIQWQECTVDKNIGSKKSKKNGSPFKCINIKTTKSEKKLRNSKNESQVRKHRLRNKMLAPKLIREKVKKNKAAEKYHILYIERKIQENIHYNATKKRFDTYCYYFNMLEIFRLRNNNSSKSLTSIILDNIMFGHNNIHTEEINKEVCYFMQTMDYFAIQSIHIQTNTHIGFDEILLRPNEIFKNLLHDCLLYELKAKSYFIENKNHEICFFLFSLISNVLITEIEEDKKISIFIKKSNDEYDVIEKSNNRIYTWKKKFEFSIENINPKKNMSSTKKKIKSNGTFNPPSYQNKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDH6</accession>
    <name>A0A4Q9LDH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2681p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002681">
        <property type="protein sequence ID" value="TBU05914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2681p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8163" checksum="80A59A601D7161B9" modified="2019-07-31" version="1" fragment="single">SFVLFKSLVINLNCAVAETFLKSASKLLITLPALLYPKPHIIANIKSIEITNPDAIIIAFFLSSAMEHGFLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFD5</accession>
    <name>A0A4Q9LFD5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_2515p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="PITK01002515">
        <property type="protein sequence ID" value="TBU06738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFD5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2515p0010"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU06738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="422" mass="47723" checksum="DE61BCA2CF7FEFC7" modified="2019-07-31" version="1">MSKIWIDGCFDIFHYGHANALRKAKSMGTYLIAGVHSTKEISLNKGLPVMTDEERYEVVRACRYVDEIIENAPFVTQLSVIQSHNCHIVVHGNDPIVDENGNDCYQEVKKKGMFREFERTLGISTTEIVGRMLLKQKPTPELCTCNRCDTTTNTSNISLSPNISNSNISSPYAQFHDALLHLFEIPKKERKGTVVYVAGTFDLYHAGHTSLLREAKKLGDFLVVGIYRKGMNKSDNKDMTDNKAGEDVTRNSNSCKDVCSSNIGDLKSSQCVFSYKERQLCLLSNKYIDEVIYDPQFNLDKQFIERFGIKIIVHNNQDGGCNVEDVKGCVKVVKINTEFSYLTSGVIIDRIVDNYYDILGGGVKYIRVDWRVLYYNVSVKRVLYYRDMINGWVIGVLLICVVVGSGVLFIMILLKGVNTIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFD9</accession>
    <name>A0A4Q9LFD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2516p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002516">
        <property type="protein sequence ID" value="TBU06733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2516p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="678" mass="74963" checksum="FF9EA1AAFD28DC88" modified="2019-07-31" version="1" fragment="single">MCLETPEKEKENMKIKLIIKREIGCYLYKIKRITEYKYNRYISRNSRVKGVIDKLVGVKGIGGVSDKGSIIRGVSDKLVGVKGIGGVSDKGSIIKGVSDKGSIIKGVTDKGSKLEGVSNSTYKQQGVTDNTYKQQGVSNGTYKQQGVTDSTYKQQGVSTSIDNYNPVSTSIDNYNPVSTSIDNYNPVSTSIDNYNPFSTTTSNIKGILGVNISTINNTINNIPNKKIRIKVINQPLGVIKLSLKQSFNDPFIIQYNSIINNSLYSTKVEGDNKGDNKGDNRGDSTNTSSITNNTNNISTNHTNNTNNISTNNTNNISTNTNTTNTTNTTNTTIIMLSILNRLISHKGFNQVESFIEEHKSNFFTFKVLTLKEIKRKVINNEYDISDMSRDSSVDSSRDSNSISNLITNSSTNPLTNSSTNPLTNNPLTNSSTNPLTNSSTNPLTTTTNPPTNNPISTNPPTTNNNNNNTNNITSAYLNMSSYNKDSIGLPFTFLFNEYSVFMREIEEYFIYAMTFMQYNSIIYNLCKSMKNIYYKDIYMLIPIYKYKDGEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGU8</accession>
    <name>A0A4Q9LGU8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2417p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002417">
        <property type="protein sequence ID" value="TBU07323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2417p0020"/>
    <dbReference type="OrthoDB" id="2189995at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU07323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14837" checksum="5920733C8551B8AD" modified="2019-07-31" version="1">MINDKTHYKEDLSLFVYFISKIHRLEPSYEKYAQENIEKPMKYDSLIQSKNLLRFKSKNTESKEHFIPIFTNLSYIPISYDDDKFLCKYCKIRYVYKRCLISHIRRKHIKPFSGVKFNYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH29</accession>
    <name>A0A4Q9LH29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2512p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002512">
        <property type="protein sequence ID" value="TBU06755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH29"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LH29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2512p0020"/>
    <dbReference type="OrthoDB" id="2192550at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="75"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="42676" checksum="9939BE421044557C" modified="2019-07-31" version="1">MERRKIRKKLLQPRIESINDLNKDLYRKYILDYIDNHYTLISRYYSVISITIIRNDLDFLEKLIYNTEFKRTNCSYLRCNIKYGQRDVKIPMEFKILMDAILKRDLRQEGLFRKVPVYTDLKMARDDYIGGVLAGENIRYLRNVLKKFDVICLTSLFKELFNLYNTPVFPEKYLKLLLVIAKMKDHSMENRNISYSNEKEICEEKLDKEILCAETGTFQTDESDATDKDLLEDIGQTSETSILEYTQSTTTDSYFESIPVDIRMKLIMKFTILSLPRQNRRFLEVLIKFFSVVHNLSIKGDKMHKKNMTLRGYSVVIMPKLFLKTKHSLDITEINELVDLSEYILFNSPSFFDIKDNPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNW5</accession>
    <name>A0A4Q9LNW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3449 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2032p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002032">
        <property type="protein sequence ID" value="TBU10089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNW5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2032p0020"/>
    <dbReference type="OrthoDB" id="2189371at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3A3" evidence="3">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor SF3a60 /Prp9 subunit C-terminal" evidence="2">
        <location>
            <begin position="299"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="49182" checksum="CA34F0D16337FB69" modified="2019-07-31" version="1">MKNIRNVYKILKLIEKASEIKFKYKNLEKKETLRQKDKIVNIYLIKILKKKFKKIKEKIYKSIKYCIIGEINTVVYDFYEDIEWLKSKKEKIKIFNEIENKISDKLENIFSNEERYGRCVDLKSIFEKYRSIMKFTEYKEFLEDFLCVEKYNFSYFSYLKELNEYLKSFCSRAKIRKNKKIENKKQENENESIENKKQEIELRDFFDSRTFCEGCNRIIMTKMVCFHIKSKRHMKNISCNLLNIKYEEIYKLEKEIKIFTKILKDEIELSKSLCNVIEIESISNEEISDTKKFAVEKNEEIPSWLKKYYGLDITFRCEICKNKKIRGRKEFFKHFKQPEHLENLKTHNIEYCDLFYGITTFSGIEYMKTRIFLDQNIFIEEVEDEEGNVYDKKTFEDLKKMGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNX5</accession>
    <name>A0A4Q9LNX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2008p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002008">
        <property type="protein sequence ID" value="TBU10118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2008p0010"/>
    <dbReference type="OrthoDB" id="6725828at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="364"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="64695" checksum="CFB8D33D7C71359B" modified="2019-07-31" version="1" fragment="single">MSYTHRQIPYLPPPIQNNTSTTMPKMQNGGLYTLPSPNGLLLSSVKSLQSNRLMALRTIFESVTTDSKEWPQIVFFCSADKQVISEVDNWRRIIATILTDLCTLTDTTEYINLRDKFLSKIKEISEKEIGKLPSELVADDFWSLLIVLSPMTINAVARIIQAARVGYDEATHKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSEMKSLKKIMREFNLNLSSVTNLSEALKKITMDESRKQFRRENPVFELFRSRFYRELSERVESEHLVSRDEIVNNHPTTFPSLDEFVNIINWLPNWKAAGIDGIPQRGSDYRPITCMFNLYKLTTKCRKEGLLSENQLGMRALLYIALNKEYGNNLKATWIDILQGHSLSPLLFVLSMNPLSRKLNEKVTKVTVQTDAESYSTNHLLFIDDLKHLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPVDFSKLDDAVRAVLVKNKIHLRPGCKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP25</accession>
    <name>A0A4Q9LP25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1944p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001944">
        <property type="protein sequence ID" value="TBU10203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP25"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1944p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020369859" evidence="5">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="48597" checksum="7FE029AF18F9ACFE" modified="2019-07-31" version="1">MNIINFCFLKRLYFLNLVCSSHISNTNKHKKISKEDFQNLGHEITTYYSYEDTIHSSPDRSLQILKAKNLITREYVLIKISKSKQYAAYLQKEKEFLDKFDHPNIFKYIRETKIGNTSCLVFPLAEDTLESLLKKQSLGNHYIRFILRQILNGLNHIHEKKMVNNNIRMDRILVKNLKYVQIIDFSKSCKTNESIKIFKSHDLNNIDKEFDYYSPEIKKNELLNEKSDMWSFGKLIKQLQEKNMSKPIYRTEDILSDYKFFTLCFLNNEAEKRISASTALMSNFFETLYEFIHCFCSIKDQNFINNNIEYTKKNSQLIITYLEYTIELFCCCSTEARGFYYTRLHEARNKDSLFFDSIYSKYYLFGSHCIFMVRIATKDYLLCELNIFELENLQINFENFIHLSIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPM0</accession>
    <name>A0A4Q9LPM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1871p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001871">
        <property type="protein sequence ID" value="TBU10294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1871p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="577" mass="68847" checksum="B184C50581BDAA8F" modified="2019-07-31" version="1">MQYLYYLISIKIIFHVINLCNVFCSIQQMNGDSNFFNEYNKNVVLSHNTKKNDHSDMTFDSSRTKEDINREFDDIKLKICGECCDIYQNPRIYNKCFGEEKCIACNKTERVCLKHLLVFHSPKTELLFKHEAAKSSKKESKASDDMPFVYNITFRSDSEMYLFISYFLNKSQKLKDLLKKNPNMPITFEELKLLNPSLLNALIEIIRIIQIENFDFVIYEKELTFKHMNVNKILNNNLLSTELYVNIIVSSFEEFDLCKFREILNEISYFLYEIESDWMDWCKEEPMIRKKIENFLNHIDSNIVTDFFLKIRTFIHSIHYDIFLSNRKQERLVEKYILLSSLMACESIYIRNHHNYDSLTNQDCQLDIKNNKLDLAKKLNEIMFRIISCVTYDTSYYISFNLLAYILNDLTDIIYKEQNEELRKACKIIKDFHLMFFFLPRIFIKKFTNVTGIIIYMIIIAHRENTFKFGFKDYFNDNFCSLSLKDCYDLVIAGYISFLTNCKLLVHIKQTDSDNIKFKYKIALKILNDKIKNANIIILKNTKYIKIYKDTSREVFRSIKEYINSNFQCIRSRNIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPZ3</accession>
    <name>A0A4Q9LPZ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2134p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002134">
        <property type="protein sequence ID" value="TBU09605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2134p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="44268" checksum="BB7A3C42B3F5B3F2" modified="2019-07-31" version="1">MYRINYQTVNSIVKRYLITGLIFVEKKIEDRRLKLTLEIKENLQTFVDLECSKTLHDFRELEVDNMTKTLYFYINHRQGILTPIFVMDNARIHHYCGLNDDEEIASILICEKFYDITGEYFSSFYRKMLGYLQKAEVGQLEHFTFLTHDICFKKRDHLIKAVFGFESALIKQISQTEQAIAHIRVNKMMALIIREYVKDCEACIYINHITKKYDLFMMDCVDLRRHDDQNDQYSLMFNLINKTSELGRDSLKFLFENFGVPVAIQSDNSQEFKNTLLEAFLTDLNIKIIHGRPHNPKRWHKTGGRRWMEHLNNVFMHIREQYIIRLDVAKHFKNYRERILENNNLNRLKRDFSSADQVLIKKTRLRYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ25</accession>
    <name>A0A4Q9LQ25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1647p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001647">
        <property type="protein sequence ID" value="TBU10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1647p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17182" checksum="8C862C27FE77A1B1" modified="2019-07-31" version="1" fragment="single">GLIYKCSVEIIPYVMTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEELDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN6</accession>
    <name>A0A4Q9LQN6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_2072p0010</name>
        <name evidence="10" type="ORF">CWI38_1586p0010</name>
        <name evidence="9" type="ORF">CWI38_1810p0010</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="PITJ01002072">
        <property type="protein sequence ID" value="TBT97788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001810">
        <property type="protein sequence ID" value="TBU10376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001586">
        <property type="protein sequence ID" value="TBU10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2072p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1586p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1810p0010"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT97788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="169" mass="20076" checksum="7CFBD0ACC679FE48" modified="2019-07-31" version="1">MEVSEEKKKKMTELLSQQLNLEYKAFYIYSACNAYFDRSDVALQGLSKYFKKMYKEELTHAKGIIEYMNKNDINIEFKNIQIDDLKIKFENLDVVSIFEKCIEFEKAVQKNILEMYKYAEENDDYSLCVFLDPYVAEQVDSIKELKDHLKNAIRCKDNLGVYIFDQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN8</accession>
    <name>A0A4Q9LQN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RCC1-like regulator of chromosome condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1507p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001507">
        <property type="protein sequence ID" value="TBU10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1507p0010"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="307" mass="33888" checksum="CFFB0CA1EEF6C661" modified="2019-07-31" version="1" fragment="single">MPVYVFGSNSISQLGLGTEIIKSKPVRLSFFDEIKIKKVKCGVIHTLLLTTDGKLYSWGCNDECALGRDGDESIPGLVNIPEEIVDMAGGGSISVAISVKGNVYAWGTFRNESGVLGFTVDIKIQKYPLKLKLKNIVKVECGFNHVLLLTDKNVLITFGVGICGQLGWKVSKRNKNCLIPTTISTTRKRKINEKFVDIKCGSSHSIAINSDGEAFVWGKNIYGQLGLNDRNSIYKRQKVDLKNIVTAEGGEDHSFFVANDYNIFSCGRNDLGQLGLNDKLHRDIPTSINVIRKLKVKNISKNIFDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQS6</accession>
    <name>A0A4Q9LQS6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sel1 repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1670p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001670">
        <property type="protein sequence ID" value="TBU10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQS6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1670p0020"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020241712" description="Sel1 repeat-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="59298" checksum="7FDC57BB3541E8AA" modified="2019-07-31" version="1" fragment="single">MIFFLFLFNILRTNEIEEILFEECNIKKAEEMALSLGKPDDQIYLYFIYRVFYGKQEEAFFRLIAGETSSKDFYKIIFSHNSFFSFGLNSDFKETADLAIKVAEKVKEVFEKRRSDIKSKRNFKKIKKEKYLYETIEHLTYLIGSGDSKAETNFLKLIKGGHIEPEKYLKVLKILSERGNQKAMGILGMLYYEGKGVEKCFTTAMHYFMEGANKQDPVCYNGLGLIFLHESHNDLLAAKAYFEEASKRGLAEADYNLYKFFKDVYMVEEMGLVYLLNAANKGFLPAIYSYALKLYQSKNYRVSLQYLCSVCDYSTDLVEIQNKAEKRFVERKYKSSLMYLLFAGEMGSIHSMQNALFLLYNHSGLIENQNKIIFDLNHRLAQMGHKNNLVKLGDCYFYGIGVEKSYTRSFSIYLSASLLDDPEGFYSVAYMYENGLGCEKDVRKALNYISRIMKYEPKAYLLVWYVEFRLISKICVQFFWRKRVFISSLFACLIGLFALKFNPRIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQV7</accession>
    <name>A0A4Q9LQV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1645p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001645">
        <property type="protein sequence ID" value="TBU10617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1645p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="24843" checksum="47C3A73BC4B9AA05" modified="2019-07-31" version="1" fragment="single">CLHLLLLNRYKFKSSKRIRSHSVQEILDNGYAEIRVDTRIKTDVKIRNYRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGISIVLKKTVETISFDRRRVLESGLNAEESWERASMGVIMRAEMHEEPIPPLKQASIEENCKNIIPLISQRGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR17</accession>
    <name>A0A4Q9LR17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1458p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001458">
        <property type="protein sequence ID" value="TBU10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1458p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020971888" evidence="1">
        <location>
            <begin position="17"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="519" mass="60959" checksum="79B94775C29DC0D7" modified="2019-07-31" version="1">MNLFTIFLIQNSLCAGISNPILDMNCKKVPDNATDSQFIQDIFNPSEPPALDPFHINIKNRHQDVIDDISRVIPYVKVIIEAHLEITKCIFEDSIKEAIEEQLNDFKKRPSDPNFKSEKLIYKSILLNFKKIFLKKYIQCCINQNTLEPNEISVLTRIVKVSTLSKDLFVKEKLNEIKSKEITEKLLNTEHEISEVLQSSIEDKAFKQIIFENLFVVFAVSLLVLNQNLPDFSVYNATKNEEYLNSEIKNNEFLKIIKKIYSKNAWPLPKSYENRIMQTSEQSKELLIKELCGLICENYQNKNYRDIFKKKIFTFIFEDDKQDRLPLVIQNVSNNIFPNDWSSCGLLCFKGILERHSNHTLYLSFSLSIEDWLIVFIRQIFLKFQKEKFYKIVSKDFPDAEAVRKEILKEIFGEIPEISPFCDDIKLFLVEVKENLKSQTYISFYIYKVEDSIFNDIITKFFEEKKISKTEILHGGNMSDIDLKIRNNVMICFEYCFKSTLTSHFGNDEFIKKKTIIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR31</accession>
    <name>A0A4Q9LR31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1699p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001699">
        <property type="protein sequence ID" value="TBU10526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1699p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="16478" checksum="4A5E96C37ADE523E" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNASVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR65</accession>
    <name>A0A4Q9LR65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1406p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001406">
        <property type="protein sequence ID" value="TBU11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1406p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="467" mass="54199" checksum="064D7EDA49DC3051" modified="2019-07-31" version="1">MKTKFSVYTIFAFLTETLNASKQRNNKIIWQTNSTYQNNDDYTIDGFDYLSFAKIFLSQSELSQPPKIEILQSEPSKAWKEHAQNRCIKETSDSKVNKENSSFKDKSLHMTCSNQTEPETAFYSSTPLPAFYIAFPEKAMKEQISKPLEYKYIEQNEVNPECSLPDTCSHSVIIDNSTICSEEVDFSAQEFLALNKAIEVPMNNPIPRKVAWKCGKMLYRKIHVMMSNIPSFNLFFNRKISQKNLNDVNHESILIIKEELLSLIFTSNSTDNCNENNYYDDDLDEKNILENLKKKIQKFRIEDGLKNDLSLGIICQLTNPSASKLIQRRLFALICSHCSVNIYMDKATALVNIYRDRFCGNKRLETIFNQEAQNIRNLKDKIKSMDFSQNKHDNDIQVLKILFDLEFRISHIEKAILGNSILVMSCYAKRGYGFTYNSIIKQAEEYYEDSHLSIEYFSIFSLLFIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR87</accession>
    <name>A0A4Q9LR87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1991p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001991">
        <property type="protein sequence ID" value="TBU10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1991p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020698396" evidence="3">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="382" mass="40393" checksum="17E2E37C6C79B0C3" modified="2019-07-31" version="1">MQYLKMATTYLIFSSIFGPIFASNIQADADAEGDSSVRDIQGEDLGNDSSSVVNNGADSIAGNMVSEGNLSTTTLNSATENVIESDLQNTTIENLNTASQNTTVDSTINQGATSGPISGDVSANLIVSTEISQGACGTTDEHNASFYKFEKPEEEGNLTESDIPLSQMLLSKETSLSGSASSFEVISEPSPSDVSLNDEPSLNYPSVSSAGSHENIPMFRVSLPSESDLNEDLPSGLSGNESLSDIDDVFSNAGNVNQIRLPETLQVNINNDQQNDSEVSSEIGSDVVSGTNIIIPNANNEPEDVSNLNQSDNLNGIHPLGNENEDALNSPSNSDIKPKDDNVTGENDKTEKKSKLKTVIVVIIVSLSITILLIIVLGLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK8</accession>
    <name>A0A4Q9LRK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1324p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001324">
        <property type="protein sequence ID" value="TBU11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1324p0010"/>
    <dbReference type="OrthoDB" id="7976214at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10299" checksum="86A694E76543B5E0" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPEYIECENDNVLKCLVETSGSHDENLSISTIPTLRKQKVSINDRERIIEKTLEGYSMSAIASMYRINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM9</accession>
    <name>A0A4Q9LRM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1993p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001993">
        <property type="protein sequence ID" value="TBU10140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1993p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="29603" checksum="383AD24E078EA67E" modified="2019-07-31" version="1">MFETLDSCNEIFEEKLNDLEISIKYPENERTTMLRSECKDLVDICLSLIKYKKYYKEDLKKFIFLRNKYFKLNIVTDNESEKIPFIQESERELDCRIKSNELRLYSLVRNHNIKNISNKINEIVNINDYIKCVVDMQDQNIDRLSHIMGETKFKSRNTVKELEVTYIRKKNKKRIIFYILGNNILKDFCKFLEDNVLKDYCYFRVLLVFMFRDNILKDYCYFRVLLVFMFRDNILKDFCYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY1</accession>
    <name>A0A4Q9LRY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1274p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001274">
        <property type="protein sequence ID" value="TBU11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1274p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="94053" checksum="8459D0DF754E8BB5" modified="2019-07-31" version="1">MEIFYLGVVFCLKLLNQNIYFRLAICKKIVFYSIENVYMEIYNKKKIEEISYEFKIESNDILKNFKSVYLLDNQYLKCKLQNGDVKYFIPNTVEISDSTDIILNFSVIEDYQANESTQNIFLGLLTNEFLFRFKKYATTEDIFVNTIYSYEFISIMRVLEICGFQKTKNNDIFLKYLLIKSIMSADFDFANSEIFLHTRKNNQKSLDSVMKHLFSMFIKFVFSEGITNREFLFSNSAILINKHRIILSYPLYIFCKEKFSKQNIFTVSFNTISYLEKILNSAWSTNCLCFFIRYIKIDFFCFDKIKYKNSQKFPTLIKIIKPRSLQKLSIVDNFGEKMILRMFIDFGYFDICESVKIVSDLNIEEIDMVLTNCTNLKRLIIVVEEAYYNIISELYEFALKNQSVCINYKCTFFKMECQKDFLLRTFPKNLIFYVAKYNISFKHCSSCHILSLSLFRKLRIYYESDKYLLFVKTCIDYGLNSKNVSFYRSTKKPKSKIHSNLLKSFTRLPKLESMSFDNIIVSKSLIRFILVSKQLKNIAFNNVKISSKKFSKYKIYNFVLQGFTIRKSNFIFNVDFLEFISLFPNITFLKIHIENIDGNLKSAMAKYASKRSKKGITSLISSLEYLKITISEYIVREFPVLFALSLLFDFKKLNILILKFYDFEEQDLQCISNITSITDIYIKFYKRYSALNLNRLITFIKNNEIESIRLDFFDLNKNIIEFLHLLRHIKFISITFSYIVKTNSNLLKKIKFKHPFAMNIFCRDNRFVSYEESNYFKECNIRFRDTTYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB4</accession>
    <name>A0A4Q9LSB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1762p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001762">
        <property type="protein sequence ID" value="TBU10435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1762p0020"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="28654" checksum="F708214793625201" modified="2019-07-31" version="1">MNNILLKDKRFVKIIDFGLSCRTNKPIKIFKNDGLDTLYYTYEYLSPELRRNMLYNEKSDMWSFGFTVKQLVEKKGWNPKYLKSIGFFDYNNFISCFLNDKAEHRISASTALMSSFFDFLYEFIYCFCPIEDYYFIKDDFIYTKKDDQLIITYYKSKIILHCSCSIKAKNFCYEKILQAKIKDSAFFYSNYSHNFQFGNHCNFMITFGSVNFLLCELDVFELENLRICFNFLTIGRIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL1</accession>
    <name>A0A4Q9LSL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1594p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001594">
        <property type="protein sequence ID" value="TBU10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1594p0010"/>
    <dbReference type="OrthoDB" id="2192991at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="19705" checksum="BEFD5F60AEAAC209" modified="2019-07-31" version="1">MTNRNCKYTERVQLESRIHLGKLEKRKDALLRLKEIKEYQENIQKVKNYIQEKTGNEYFHDISKYKVENGNFIKVSIDLNVLKKNLLLINNEITRAEKKIKKYIVNPSGKHIYFDKQVSFDCKLTETIDFDKNSNILKKYTNYIQKLRNTRNEILQKIENCKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT29</accession>
    <name>A0A4Q9LT29_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine desulfurase, mitosomal</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_1580p0030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters in mitosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001580">
        <property type="protein sequence ID" value="TBU10735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT29"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1580p0030"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1025">Mitosome</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="15">
        <location>
            <begin position="41"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00084113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="449" mass="50197" checksum="CC1386B9CF93FFD0" modified="2019-07-31" version="1">MPNFLSNIFKNTSLSNVNSILQPVCSIRRYKTNECKEPKRIYLDFQSTTPLDPRVLDAMLPYYTSKFGNPHSKTHSYGWEAEKAIEKSREQVASVIKADPREIIFTSGATESSNLAIKGVVKFKMQENKPIHIITLQTEHKCVLDPIRNLEAEGCEVTYLKVNKDGLINMDEFKNSIKSNTVLVSVMAVNNEIGVVQPLKEIGQICREKGVLFHTDAAQAFGKMPLDVNDMNIDLMSISGHKIYGPKGIGALYVRRRPRVKIHPLILGGGQERGLRSGTVPTPLVVGLGKAAEISKTEMKKDFLRIRKMANQLLEYFRKKLKDVTKNSVEDNLESDIENAKVYPGCLNISFSYVEGEGLLMSLKNIALSSGSACTSSSLEPSFVLRALGTDEDLAHSSIRFGMGRFTTEKEIKEIAKKTVDSVKNLRKMSPLYEMVKEGIDLKTINWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT97</accession>
    <name>A0A4Q9LT97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1031p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001031">
        <property type="protein sequence ID" value="TBU11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT97"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1031p0040"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Upf1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="352"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="713" mass="79998" checksum="F58DF23E1F06AF23" modified="2019-07-31" version="1" fragment="single">MKCLYCSQTDYMYKCGTCKKCFCNNPCSPITHIYHHIVSTKHMNVEMVKCHKCQSNDIFRLYVKNSDILYILCDGCVDGEDGYKQVVFDNRLNVGKEEGGACMENVLKQGITGSRSNVGKEVGDENLNGNKNVYSNGKLSEGGYKKKEMQLKFTEEEYISFFTKLVQLEHQQEKILKESLKQNGIKIEFKKENERLFGTFVIPQRDSRVSVGDELYIVSEVDSGKSGERVSSRAFVHSLSKYSEEIIVEVFSQKVVSFEKFSVEFIVKNVGYDRMTNAIKKIFSKCSKEIVDIIMGNNIEEITNKKINEKCINNFVNNIQDIAKVDKCMNKNEEVLTPPNFPALNQTQLNAVAKALSSPLTLIQGPPGTGKTITTAVITYNLIKRDKGRILVVAPSNTAVENLTEKISKTGLKVVRVVSKSMEGVVEDKECLTLHEQIKRITQNKNPNSSNHTVELQNDHQNSHDRKKMMDLEIKLLKMADVVTCTCVTAGRKPLSFLKFTTVIVDEAVQATEPLTLIGCTMGCQKLVLVGDHKQLGPTILDIEASKLGLRISLFERLIKLNLIPELLAIQYRMHPIMCGSVSSYFYNGMLFNCYSGGGKIISILPLPCFFLCVYGKEEVSESGLSYLNREESVRVGGIVRKLLQCGVQGQEIGVITMYEGQRVLISKMFCNEGEEFSKVEVANVDAYQGREKDYIVFSCVRSNDTNTVGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD7</accession>
    <name>A0A4Q9LTD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1053p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001053">
        <property type="protein sequence ID" value="TBU11754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1053p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="11933" checksum="20ACE07E620E44FA" modified="2019-07-31" version="1">MSRKGKKLVKDSYENSSEFPAFLILYTNNTSSINPNTILDYVADTPKNELELFFFVAESRCYNEKFGRVINFDVFKSQNKFSGKKVELVENRKRLIIAYFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM0</accession>
    <name>A0A4Q9LTM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0966p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000966">
        <property type="protein sequence ID" value="TBU11949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0966p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6331" checksum="34B714FE2F1ECEA0" modified="2019-07-31" version="1" fragment="single">ASDVLSSAKYLCISRLNQYVSVQVCNDLSAMSSCLRVIFKHVGGLGTLNILLLAIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX3</accession>
    <name>A0A4Q9LTX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1110p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001110">
        <property type="protein sequence ID" value="TBU11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1110p0020"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19703" checksum="D5F5FEB2731F9B88" modified="2019-07-31" version="1">MEKGVSDKDMLEGVISNDKDMLEGDMLEGVSLQRLQKEIKTLIEDPLENIRLVEFKDIRNLKLEITGSSGTLYEDEKYILSVKIPESYPIDSPEVIFSNTVPLNEHVYSNGHICLSILYDQWSPALTIKSVCLSIISLLSSARAKKKPANDKLYCRISQNRSPKSFKWEYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG3</accession>
    <name>A0A4Q9LUG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0956p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000956">
        <property type="protein sequence ID" value="TBU11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0956p0030"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14571" checksum="A47FD85E267EC19B" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNIEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQEGTTLEEPNNNIKKMVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR3</accession>
    <name>A0A4Q9LUR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0771p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000771">
        <property type="protein sequence ID" value="TBU12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0771p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="13300" checksum="EE4844EAB6B05200" modified="2019-07-31" version="1" fragment="single">DIIDFSVFESRKFIKYYLEIFENKIFKEYINIPEQKYERHISYLNKIRENISQNLTDIEINTIAFEALEKTQIFIHYYINVKVNSMIFTDEYKEKMLEAFIEEINYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW9</accession>
    <name>A0A4Q9LUW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0922p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000922">
        <property type="protein sequence ID" value="TBU12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0922p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020519756" evidence="1">
        <location>
            <begin position="18"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="780" mass="93077" checksum="7C80ED8F03054AC9" modified="2019-07-31" version="1">MSRNILFLAYILGLCHCSNEITFLLNASFLKETIDRKNIDESFSYCCKPKNDVINCSGDHFLKNNCIACTNYGSDVPHFLLKKHTISYPNDFPLISKYIERVIRETKDDNVEIILENCFYDDFIVLLKNLKDPDNILAQLRTPDFNFILMFFAKFEISYSKHLKLFLKSLGVNIFLHDVSFNKHDAIEFPNDSIDKINTGLIIVFVEQLLKFYFLKLSKMIYLFKKNVYYLDLKRDFREKIFSEKTRMTISNHNQTLFNKYMQKSLFFESLKILLIAMKLKKLVIDSFSKEYKWKQSDFINMIPFSCAKIEILMYYAEPNLLKYLYPILTRPTIKKFKLSVNIITDETVNFLKMIKVPKQHICIHFDSHKNFSLLEHIFEIIDCIPEAHISLILSYTIFNNSLFLPKKYLKIIGNERLTLQVCNILAINFWIYEYWNSPNIEKFIKTLMISSHRVLDNKQMKILGRFKNIKEFFYFYICNTTFPNRTNHKFDFLSNFELLKKIRLQNANIDTELIRFIFYSKTLKHVYFDRVDLSKISESCLEFKGENLYLEKIFILYCFGEIPINLLKYLQNFKSIKNIKVSTYDSYQNFLYFEINFYIKKDREFEFFYNKQNHKNHLYIKKLSICHIMLNSNTANIIFNQKWKLSRILEIKLEDITLSIKNIIFITALKSIKHISLKEVRFINCGFKDFLSETILSQLFVIHLNNINLYKSDLARVSQLKEIKFIELNFCRISDENLAILININFKRLNEFILQTERPAFFLKKQYAEISPSSHLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY1</accession>
    <name>A0A4Q9LUY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit 4 of CCR4-NOT transcription complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0870p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000870">
        <property type="protein sequence ID" value="TBU12167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0870p0030"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="22262" checksum="59D69318A03B4467" modified="2019-07-31" version="1">MIDRLNIGETNYCNIRVIQKNLVYVIGIPQKYADDNLLKRNEFFGQFGSIKKLVVNKRTSSLDTTASAYITYSEESEASKCITEVDESLLDNRIIKCTYGTTKYCSFYLKNVVCQNSECMYLHEPGSVCDSLTKDEMCNSKHKLHSFESKNKNKEVIGKKTDIDISLHSLFKYKEKRNYRIPEKINFEPNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA4</accession>
    <name>A0A4Q9LVA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1066p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001066">
        <property type="protein sequence ID" value="TBU11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1066p0010"/>
    <dbReference type="OrthoDB" id="10657662at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="562" mass="66219" checksum="D63BD0EAE22EEAC3" modified="2019-07-31" version="1">MRKIKLKVYDKFNKSHILNTYKNMTVGETLNEAFPESDTLVIKMVTKEKKLRLDMEENGELVKNIRNKKPMIFDLNDDELKKTSKKVSKNYKKTKTSSKYICKFKIIERNTRIEEILKEIIFSGYKFRFYLVDTEEFIEIYVNTCVRYYSGGNSSYKIYCSENTTVDDIENEMAMVFNAEKVFGLFGYNHLGLFKLKKNEKVLVIKELYCIAESNFNFFQLQFKNVNDALLQMKPIYSARFYKLQTKNDILLFKCMKEYGLVENALFKIYDNNRKLVLENIDQCKVFLEKYYGKFLLIIEDGLNELILCNYDEEICEQMYFSLLGCKNKSLIREIAGNEIKNVSFENSNYLETSDKFDLSFQNSNSFVKNVSQDISRDEFCKREATKVKEFQENKTNNENESISKILNEMNSFLESTYSTEGTLKSSKRNSDITLNTSQQNLDNDFVDKHTVTFQNNDLNEISSLIKLNPITKTETKRDKKKSYKRNKIKKVFQNINHKKTEKETSSTSESNKLENSIYFKNQPKNNVPRNFTENSSDYSFLLEETESSQNTEEFIHSYFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN9</accession>
    <name>A0A4Q9LVN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0798p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000798">
        <property type="protein sequence ID" value="TBU12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0798p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="735" mass="87465" checksum="DE5C5B599D468974" modified="2019-07-31" version="1">MNCFVSSYILLLFYSHSSINSNLIFLFDSNNVFNNPRILKLHKKYRYYGKFEENQGFIKYFSTNNAFESENGSNTNHEDKYYYKYLKETNIMYLDDLKIQFHFIESYLSNNLIKMPIYIGNIITQKNFLIFLDLCNHEVYNSKKRFNIDTIRQVLSLFEYLIPVYDSDFQKICKIIMISRIDFHLNDRHDFDIESFELLETTKFIFLKTFIEILNTHRLFVEINQNFILIDGAKHENLLHNRSRLSLKYNLNELIITRNAILSHFLFQKDSSKDFLRFLSRSIIFCGFKKFSLIESYSDKVSSRIIENNMMLTEYICQNNVSDLYGLSNMFIYFEKHFLPNKITDLKIMNDNISVNILEIILKFKYLISLELKFFACKKLNTFIRKIPSSLIYLTKLRIESIDSEYIDVKNVFELMLREIYLIGYFFHSSLNFTGISLQRNTIEFLNVSKNQISYNFFIFIEGLEKLIDLDVSYCIFYDFMPGCRSLINLKRLNISGLKKNHIFKILNYELPNLEEIIIYDAEFLKIYLLSLIKNKNHLKIKRIEIDSSLCFRLDIFPFYLFPALDSLVVYNCRFFHKLLFGCNNLRLSESLLYFVVSDATLYKSDIILLHTLTNLISLSIAKCNVYRFSNILLSNLSWKAKIENLDLSLTKIDVEVIKDIEQFRNLKTLGITLYLKEIFVFQDIIIKNFKNRKIVEIIFMKGVITSKLIQLIGNIENIKSFYTINSIIFYHFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP0</accession>
    <name>A0A4Q9LVP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1065p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001065">
        <property type="protein sequence ID" value="TBU11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1065p0030"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="117"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="35827" checksum="5531DCC4F0B9457A" modified="2019-07-31" version="1">MTAAMSLPRGYVLKKAKSLCIIVILISILEWLITSVIVYIFSYYNLGVSLAISACLTPTDPVLSNSIVKSKFSQENVAPRLKNLIIGESGINDGFGYVSRKALKLCYTYHLVGTENFLIYGIALTFFSVGMMDLVGGSEMVCVFFTGTAFSWDEWFILETRESRLQEVIDSLFSSTFFVFFGSRIDFSRFSFNILIGSLVILLLRRPPVFYIFRRFIPEIRNRKEALFIGWFGPIGIGALFYSLTLDKLIGTLIFFVLLNHRKNHKIIQIPINIEAYIQSILRKHRCVFYNRQMYRTINATKIQESNELGGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ0</accession>
    <name>A0A4Q9LVZ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0591p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000591">
        <property type="protein sequence ID" value="TBU12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0591p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="97384" checksum="59FB890D18F3F240" modified="2019-07-31" version="1">MYFGKKLLVFKNSLKYKNFRSCIFIIIISKFLRTNNCISIIVDFENYTPEQACFIDPLISYDKNIDSEGGITDFKQTKSRFLPAIHRSKASIRQDYCKLPIKKRLYNSINDPSSPYLDDIGTCLNTGGVLNSEIDTIEKNIEGCTSFYTELDVSGEKQAFEASASSREPIDIVTFDYSDSFMIRSKYLDELEKTEKYQIKLNIRDITKSEVDSHIFRECMNVLENGWNLDFLGIKKEEFLTLIWLLYDLRCYTESDALFILYKNLLSLLLIYLSNSTLPGELNLFYADFMNHNKYFLPFIFILYDNIYVKYDSKTKELSLIEEKKKMMYTSFEEQDIDEIIIRTTPIVLELINKENSKDKLVLLNFIACSYRIKGIKISNKDMYYTERKDLNHASKIMNANSIIDKMNTSYVQVFTTTEITESDDIISIEFENIVISNSDNDFLIDRKNLESLILVRCNIPNTNFLRRLSSYFPKLRNLYLVGFILNNKFFRYLHVMKIECLDISFCKYKGNPAGLNPQKHEKLKELRENYTQINYKILNSIMLCNALEVLHIRGFSSVRFIHFEDCKNWQKTFRSLDLSFCQINSVYMDFFSTDIKAENLFLDQFYKIDCFKKILNQKSLHTSTKKLTLSNNLISEYIFSYLAAFEVLEYLNLSFLKFNSVNFLNSDFKFKSKLVFLDLSGIELQKTNFSFINQLDYLYRLDFFDWKLKCEFMSHLTNSLLIASLKEINLSGNILCSSDISRVCLLENLIHLVITLDNKVFSEFLKEYGVLECLSLETIVLINTNVNVDIKKFIISQPSLKNVRLRGCMTEPNYLTMNSNVSPDFFKTIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW51</accession>
    <name>A0A4Q9LW51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0982p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000982">
        <property type="protein sequence ID" value="TBU11915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0982p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="31672" checksum="BB80AD2C24EEB59A" modified="2019-07-31" version="1">MLKKERYTPEDYMYLEMKILNPIYYVSKGNTLTFTVAYVLLFFIFYTLFLLYYIGIVCFFIVKFECEEVYTVLKKYFVLVNLFTPHIVHHIMFMYKDHDITFLKLSIYNISILLCILSEICIYKHNSLNQEKILPIIIVFIYQIIRLILSFKYFGDFIFFIFKFEQQTVRNTFIFFLKFIMFFIIDAFFKPFLFNSFSEIFFLQSIFLVFKILYVAIFIRKTKYILNCIFGVIFYILLNFIFEWNILQLIFDKKKPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW67</accession>
    <name>A0A4Q9LW67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0725p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000725">
        <property type="protein sequence ID" value="TBU12516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0725p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020531965" evidence="1">
        <location>
            <begin position="16"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="638" mass="75786" checksum="6951591819DBD96E" modified="2019-07-31" version="1">MLILYISLLFETVLASHTMMSRGIVLCGRRWPMNFNNRNMRFCQITKPLYSGNTKSVGTFQEKKPGDMFCGRIETVESMTEKEHIGGNDPEDSYKKETESFESITENEIGLKNIKRRNIMFWNSVLKLKFNLNISYNLISRKEEINTLKNLEKSITKLFFPYQAFTMDINKDKDILKNKIFKFDKKIFCKIEDLKNKVDYFITEEKLISKVNDCMNISENNIILKNYIEGDKYFLSFEKLPEVFNKLEFTDPLSWAEFFHDCDDVDLFSSCFYFIKKSYLVDNKFEEKICLTDSDFKDMKKFISDLKSNIFSDFDFKSVSTFKYKKEKKESVDSKYGVSNDEYLVIYILESIRTNKFVYPSEDRKKEKDLSIFEKYSKNLIGLNFQTCLAIKNFVENFLFEDKNIKKENIRKIMDLYDLIFVINCDKYDSLGYSNVGLFFINFYQNIHESISTENRNFFYSFLEICSNFRRFDSLNLNFNLNNKKIDSLFHLSMIIISLNIDETKMTETFLRNLKQDLISCFYLFYGKNGVSSSFDTVNNTEIKIDNQSSFNLHLKNILEKNKIFGKNIYENIKEISMLNEHNNLLNIFTVKNELNVEEILKNLKNIEIFKNFSFENEEKVKKIIEKIYGNQKRNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC4</accession>
    <name>A0A4Q9LWC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DMAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2613p0010</name>
        <name evidence="3" type="ORF">CWI38_0945p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002613">
        <property type="protein sequence ID" value="TBT96948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000945">
        <property type="protein sequence ID" value="TBU11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2613p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0945p0030"/>
    <dbReference type="OrthoDB" id="2189046at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031504">
        <property type="entry name" value="DMAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17024">
        <property type="entry name" value="DMAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT96948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="133" mass="15843" checksum="1FA95ADCA82360D6" modified="2019-07-31" version="1">MENKKEKLEKFGKKQILLVKYENILKNIDEYKKQRNDIIRLHFGELNTYNLREMRDIDQKILEIIGKEPIHPPVFLASSLGFNKMNWNKSFSKILGHFNLGQRLKYPTAKNAFKFEKLKMLLIKYQEISRGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD6</accession>
    <name>A0A4Q9LWD6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0673p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000673">
        <property type="protein sequence ID" value="TBU12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0673p0030"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="50378" checksum="2ED14836138DC77A" modified="2019-07-31" version="1" fragment="single">MFPYNLPISKYSTKILTTLKNNNTLIITGSTGTGKSTYTPLLLHNNGFNKILVIEPRRIAVKSIYNTLYHIITDTGYNKEKFKENRDIKENGDNGEDKRDTKENRGSKENKGISKENNKYIKEENNRDNKNHTNTYTNTNTNNILGYKMRFDSHNSKNCNIKIVTDGTFLNEVLKSSKGRESKNSRCNNIYPNPNPNRCINNISNNPISTSSNIYPNPTPNICINNCNTDIPISNNKYHNPNPNPNNISNNPMSTSSNIYPNPNPNPSICINNISNNNTKNNITINNILPYSVIIIDEVHERSIRTDIIISYLKYINFKGKLILMSATLNTHIFIKYFNCNIITINDICYPIKYIYSECAVSDYIIEAYQKIKGIVSGKDIDMFKGGEGVNDSSRLEGVNDSRDRVGGVSHSSRLEGVNDSSRLEGVSKSSRLEGVNDSSRLEGVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE1</accession>
    <name>A0A4Q9LWE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0543p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000543">
        <property type="protein sequence ID" value="TBU13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0543p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="710" mass="83642" checksum="D5DF4587A4EC39B7" modified="2019-07-31" version="1">MASESINTCTQPPNIYAGGIPEQNHMENPSVPTPTYIVSNKDNDVVFEINNHEIFKVIISLCRKDEIRRLEYFYPLLDHDYTISFQNILDCRKKINNITETIKTLVEKILANRKYEIGFMCYLMKIFRLKAPFIFHARNRPMIYCKPLFLLLPLWIENTIQNELTLAKHLFNISLILNVTKAIMKYNYKCLKPFIDQNIRENKQVGFSYHFSSQKSLIYNHFNLIIKFFEDIFIILGGEAYYKIFKCATDSEFLVNNCNNVFSFTLAHFEITAILFDVLKTSQENKDLKFKSYIKKTLNEESYLQNENSMVGHENPYSLDNPKGNRLSALLTICDSVKTDQNEWPQIVFFVVQTWFERMSRNAGHSFKEFIDLIGLEINKEKSATNDTCCQYTATILELDDAVRAVLAYIVLKISTRRAAILKYRLVEAKAQLAKPYNEIEKQKLHSKLYTARKNELVSVSDSSRWLKRGNIRPRDEAVFCYIQDRNIFCEGDCVCQHRGKYKFKFLKRIRSHSVQEILDNDYAEIRVNIGIKTDVKIRKIRPDIFILDKEKNSITFIRMESLSKLLGYVEIIPYVMIWDGIVRKYHKSDLKRLEIHMNVEAYIQSIVLKKTVETISFDRRRELEPVYKVYRAWKMRQCEPIHPLKQARNDENGDKEIKTKDHTPLISKGETGHKHKSRVGFRRRDGCSKRSRRKYMKMIKKVLTQNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE8</accession>
    <name>A0A4Q9LWE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0541p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000541">
        <property type="protein sequence ID" value="TBU13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0541p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="478" mass="55311" checksum="6C30AEFF982A3F0E" modified="2019-07-31" version="1">MDNIATITFLDLKSLNYINIEECINCLLYKENMSLEIMECLNIKNYIRNINKFRVKKLKKMKLEDIHLTLEDLSSFLEFKNIDNIEFDNCSFDEGEISGEFTFVFSYIQINNMKISNLVVSFLKKAFFGFLYLKNVEFINSFGLLNIFSDTEGGKHANIIELTDLNLNDNFFDLIFYFKNLNIIEMKSVENVSFKIKNKERLELIRLKRISIKDCGLTDETSNIWFISGLNFLILYRIKNISALFKNINDEKNTESLEVLKIKGTPLCHSDMENISKFSNLIKLKLHSCNLDSSHLIYIKKVTSHAEFRKIILTNNKIYEVPGGCRGIFKNFVFAILDRCNFCAGSISLLFEEAKKSCIEVLDFSYNSLNRNDLIFISALKRLVVLKVNGVKLEGDAELDNLTLKGLPKNLKYLEIKQLNICTKDIEALAKFTVLNELKISEDSYKLLKKTNIEIPCRNIRIGKKKDYDSIDSKETDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS6</accession>
    <name>A0A4Q9LWS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0500p0050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0050"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="364" mass="42707" checksum="B1BBC6DC878BAF80" modified="2019-07-31" version="1">MTNIDGFYIETSNILKEIIEKGGTIRNICYKKSQPAKYIALLQNVLTNYRKIKSIVKETGLFIKNKYLSVILCYEMLENRVFLKEYSDLIIKIKKQNIDLISYKPKKVFVRINKLKKNTNVLEGFDVLRTDIPDVYEILNDTLLYRNEFYKKYFFYIQNVVTCIPPYILNPGKRSFVVDCCAAPGNKTTHLSMLMNNKGKIYAFEKDKQRYKILKENVLNSGANNINTKCMDFLRTDPLDYKEVTHILADPSCTGSGLHPYYQKNTERIKKLSNFQKMLLNHCFKFPSVHKIVYSTCSIHEEENEEVVKEVLEKNPDFKLKKIRRICSGKRGNKSYNFYKKVLKFYPSLELGTIGFFVAFFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW6</accession>
    <name>A0A4Q9LWW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0489p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000489">
        <property type="protein sequence ID" value="TBU13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0489p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="22064" checksum="03300C2F72FE72F5" modified="2019-07-31" version="1" fragment="single">LEILPLKIILIQICFGFKNGIAMSKRFITVYLLEFTYLFMAGRKVILGFDDEFYRIIILPLYHYIYDDSLSLCGELYARIGNVLALLSKKEYNKSYDIYTSFSKIMDHISKKNLLKKFEISLKNLYSEFTISDIDYPECLRDVRDFLQRIASSILNFESLDHQEISSNINSCISYIYLLGLSIYKNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX3</accession>
    <name>A0A4Q9LWX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0869p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000869">
        <property type="protein sequence ID" value="TBU12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0869p0010"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="209" mass="23748" checksum="9F0B06F61C138C9F" modified="2019-07-31" version="1">MGKTIGVISSETKNIENEIPGEPDTIRKKKIWTKNVMFPETAKKISDSIMNFGKECLDILLLANWKGFSGGTTDMLNYVLDFGSNIIRILSKLKSKILVYLPPNAELRGGTWVIFDKKLNANIRICAHPKTEVGILEPDGLSAIKFKEEERIKVLERSGMEINVENLNKLGHLFCKLHDSTERLIQNNIIDEFVSVDMLRKYLIENVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ1</accession>
    <name>A0A4Q9LWZ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0476p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000476">
        <property type="protein sequence ID" value="TBU13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LWZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0476p0020"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="2013"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2328" mass="277627" checksum="1F4E18FE52DC0BBD" modified="2019-07-31" version="1">MVKNLISKIICENMLEESVFQLLNDDLFQNIGQTSLCRWSNLLKRYDDNLLSYSRLYFNRKIQSKMFETPIKFKLLYIFKILILILKHTSGHELYEFNHEISVYMYSYDLDISYYSRLFYNEYFSSTRINSQDCIYNFLKQSDSLAYLERNYKLTVDAQNKKISCDFTYEKYKDKKILLEIGSLVLENRNSFKNDSIFEIQSKITNFTSEMAEILKYEYFKNTELQKLLALDILLTNILLKLCHNFNENIIECGIIFFIYSDINEFLTDALYISFHILLYHNQSYDKILFNSEIDYHINNFAICENISKENGFPIKEIFMYNFLFLLKDFVGKDLTIIDNEIQELIITKSFRIDKIYQKMNLIIQRMLEQETLQIHIDEINLNIFMSSFETLIDALILFDSNNSFFTKIIEEESFDSTIMNTFWFLGKLSSMNVINNFDLENKIVISFSESLIKLLENEKHFNRDLMDIIISDALACSIIENLEKHKIRQMNLIDKLFEYYFTENTSISSLTFDNIYSLIKITVKLQINEFNVTIVDNLIKFFFTNIEFSLLLYKANLKLKFENRKFINILNSIPNAMLNLDYIVKYISNENNYKIIDLDLFNIYKSSFYADKYVEKLHKYFEDKDKTAVDIFLYYELHLKNLLGFLNNLLKSSYLSLVVQSSNYIDQLIRNPENLFFSRSKIIIWDIAKHISQKTSASQDTSEFFDKFLAFTLDKVICNSLSKNHYNSSSEIKISKLLCYFIDFFVYFNENFKYICEIRNPLLKKELYIKLLQIFKIIYSEIICSIDISSIKTWLIFKEENLSNENIKNIFMSQEITIKELYELCYVSLLNILPKFGLQYTQRLFNSFIPQDTPYVLEINHETRSLDLNLFYMFYLQLRYNFLVIDSFFNEIFDMFCELSNFALKYSKKHEIYKKDTYNIILKSFELFMFGINKMNRSNQGCYSAKKILKFINDNIEIFSANIFMDIFTNKIMQYPNLRTILSDINLFETISNIIHKIDKNSLKSLNTNNKIEKNTLLYKFLHFSLFNLEYSKIFINGQTVFESLFLFVFYEINENTDVLKKFILRHSVTNVTPLYNILISNINININKEKKLSYRRENLLLFLSFDNNMIEESIFLYLISLVRLSDYSNIFKKMEIYQIYGFKKGISLITDKKYSLEVKNNFLNYLYLYLRCLLEDDLYFLYSLIYISRNYNNFSESVFQYFYSKLIIYESHTSHTDFLLDESNIDLKKMIVLDVFDATKVDNIFIQIVSLQFLTEIIYTFPYLIYIINYLDIMNTYYKKMIYHVLDDKFCLENQEIWYLNFKVGYFFTILLYRLDEEFMSKLVENFCKGLRSSDVNEVYSMITFIYKLFLSEICCCRYSHNIIFTDNNFYDLNCENNFFERRLQIVGKFMEMGLLIKLISVYNMHEFMYFYVAKIIDFVFNLAKNKKYILRTKFLTNNAFSGSSSSKNMIFIPNFLGQVNLHEIEQVEFDINGTKQRQILLNVMNRVLFRLDFGFKTKNHLIISKYRFAYSFMIFNAQIQTKKYDFGIEEIDSIALFTKKFDQEFDKLKFMKKISEYNLSNLTLKDLAGKIGLENFIEVKNNKNQQNLQNESLVQFFMYSKGNIKSSLQINNDFTILETYSKFIKTLDAKQLSYIFSYLLFRSEKNYYILSINILKNILRVCTKNKMMEEFYSCFVEIIKSFKTYNEDKIVKEKLKTMWNIVEGFDLRKVFENDFFIVEVLIITMRIVSNDKISNFDGDSDFRILFDSIFDQRSDSSCSSIDYLIKNIHEINSKCTNLGFYIAIELIFIFTKMMENSILNLLINSTDSSRNSIDNFYLQGLEKLICSLDNFFIEMTSELIDFIHYYLIQISDILLQNIFTKFLEIKNIDSEYFFDLYIKLIIKNSSMYLNIREAIFENQCFEMKRLSFIYSDFLCLVFDISNSNFVREIRTNHFSTSMYDLYYFFEYIYKYKQNKSTSLDLFPFININTKLLICKTRHLISTEFKVFYIIIEVERRYLLNSTLCNISSFNNELLKDGIWQIKFVSELGEGVGLTHDFFTQFGKEIDRCLFFEAFKNLDFYDRSKIENEDDNFIKKLYYFTGLIMGKSIMMNTILGFDFIDSFYLYLLKDTFTVEDLKHVDKEFYSNIIKTRNETNIASLELTFSISFGNSVNTLEFVPNGSNISVNNSNIEKYLQIVTEIKLFKNMIVYLEEMKRGFKFIMNDYLSEMFTLEELKLLIEGVRIINIDIWSSSTKYTGEFHTNHKVIETQKKILYFVTGLEKLPIDGFHSIKFYENPFTIESSFNTNLLPYSQTCANLLIIPLYEDEQTLVKNLMIAIEITEYGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX47</accession>
    <name>A0A4Q9LX47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA repair protein Rad4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0460p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX47"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0060"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="1">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="40861" checksum="CFB7550B75A377E3" modified="2019-07-31" version="1">MSVEYNNYNKFQILISKLKDFKFENENDKNIFIFCHTVHQKIPCRLFFILGKPINTFLETKLLNNLIYHPKKYPHLVFSIDSKFNITNQTLSYSSSSKNFSFFEKIFLVLDQLLINNNNSDFDKENDKKLKEIPNSIQKYKKHPIYILESLIKTYQIIYPKRPILGYFKGEPIYYKSNIINLLTEKQLYRKGLKPKDKKPYKIIYNSKQEKIYLYAPWQTCKIEILEFDSKDTMDFYHENFIPINCTHINDDKADEVAELLQIEYRKCFKGFYNGFPKIEGIFIESKHKEVFEICLKEYKFNTRLDEIIEKRMKVFKNWNIFLKKVDKYNKIIDRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB0</accession>
    <name>A0A4Q9LXB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0439p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000439">
        <property type="protein sequence ID" value="TBU13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0439p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="327" mass="38819" checksum="2282416450BBF4DF" modified="2019-07-31" version="1">MEEIFLLENLKIIFSISYFGLNHMGYFEYPISVAEQIHYVSIHDSQIDYCCLQTILKFSCLKSLSISRTFIATLPKTRPFFKNTKLHSVSFVDVRYDDFKKFLNLLNYFKDSNNFKFEFETPSFRCSDLQAEDYDFVILKLFTLPSACMPKKSVYLEYVDKNLINVSLDFYVSFEQLLCILTISNCSSLSTVKIQDYEIKSSEMMFLHEFTNLDSLFLHTSQQKAFLYELFGHNLYKSIKNLYFSKTCIVEQDTNQLSLFENLESLTFHFCTFSDSSKKLPMREKLKKIKNISIIQLSYEFNMELIKFLEEEYKNIFEVSYKKEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC3</accession>
    <name>A0A4Q9LXC3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_0621p0020</name>
        <name evidence="15" type="ORF">CWI38_0432p0020</name>
        <name evidence="14" type="ORF">CWI38_0811p0030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000621">
        <property type="protein sequence ID" value="TBU01818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000811">
        <property type="protein sequence ID" value="TBU12304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000432">
        <property type="protein sequence ID" value="TBU13433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0621p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0432p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0811p0030"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU01818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="185" mass="21922" checksum="7B170248DE58C8CC" modified="2019-07-31" version="1">MADENEPTFGFESFIKEKLNLKEFDDIYCIPYQKNLCFNKNCTKVHIKLEKAVVCKHWLRGLCKKGIQCEFLHEYNLKKMPECWFFSKYGECSNPECTFLHIDPNSRSKECLWYKRGFCRHGAMCRNRHIKKKLCFSYFFGLCLAGPLCELGHPKYDIPNPEEQRAVQEKDIIYRPKNLVADNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH2</accession>
    <name>A0A4Q9LXH2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0707p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000707">
        <property type="protein sequence ID" value="TBU12571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0707p0020"/>
    <dbReference type="OrthoDB" id="2195721at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="4">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22026" checksum="A1F3EA518AA976A6" modified="2019-07-31" version="1" fragment="single">MTEADSPTLKNIKSTDWKIRLQTYQSLQPHEISPEIIKTLTKETTVPVLEAGVSILLIYKPSYLYPHIVPLFCNLCTSKVSLKSKILEIFFYILNNLSKEVLFDLFIFLENKNPKLVCSVIVLIKDVTKQYGVIYNVEGVNLSNLLQHSDSSVRKEAMVLIIEIYKTYKERVLIYIKGVKPIILKNLEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK8</accession>
    <name>A0A4Q9LXK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasomal regulatory protein Rpn11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0991p0020</name>
        <name evidence="8" type="ORF">CWI38_0525p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000991">
        <property type="protein sequence ID" value="TBU00481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000525">
        <property type="protein sequence ID" value="TBU13116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0991p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0525p0010"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU00481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="291" mass="33020" checksum="90273DDF91D4F309" modified="2019-07-31" version="1">MEYPIMETEENMADTSETVQISSLALLKMLKHGRAGIPLEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVTVEAVDPVFQTKMLDLLAATGRHETVVGWYHSHPGFGCWLSSVDISTQSSFEQLCKRAVAVVIDPIQSVKGKVVIDAFRLINTQMSMMGIEPRQISSNIGYEAKPTLVSILHGLNRHYYSFRINYRKNELEQRMLKNLHKKTWADTLKIGDKLQCRNDFKDLLIKYFKDIEERKKLLEKGKEISKVGKADNRKCLLDAVTDISGKNSIYDILYSIHYSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP4</accession>
    <name>A0A4Q9LXP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative sphingomyelin-like synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_1267p0010</name>
        <name evidence="12" type="ORF">CWI38_0679p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001267">
        <property type="protein sequence ID" value="TBT99647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000679">
        <property type="protein sequence ID" value="TBU12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1267p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0679p0030"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT99647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="256" mass="30013" checksum="D8D582CB932BEFEF" modified="2019-07-31" version="1">MLKKILKRYNINSKNIFVLLSVVGFTIFTLYMMNLMSNVASFWSPNNKAYEPLPDLFFDLFGYKSVEKIVDSLMYMMLISTAIAILIRKDAILIFFRLATCISFSYLLRMTTVGITNLPDPNLDCFQVVEDTLTEASYRRCGDNIFSGHSIIILMCTFVWTKYDFFNNELYWLIMSVFVWIICITNLVCILFARYHYSVDILLAFYICSSVWLIYDLIWTKYLIKNAYIASLIKQEDINNRIVNSLTEYEKETKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ4</accession>
    <name>A0A4Q9LXQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ERCC4-like DNA repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0385p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000385">
        <property type="protein sequence ID" value="TBU13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0385p0020"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="7">
        <location>
            <begin position="584"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="688" mass="81831" checksum="7E9BCB3BFE1CEB2F" modified="2019-07-31" version="1">MLLEYEKEILKEANGKNYLLIMARGLGIEDIILQNIKMYLNSSSLVILLNLSLNEEKYFFSFKNKYLHNLNENPMTIDKRKALYKTGGVFYVSSRILVTDILNEVIETTKISCFLINNAETLKENSTEEFIIYLFRERNSEGLIKAFTVFPHVIMSRFSGIQQILKVLRIKKVFIYPRFHKTIKKSLAKEIELNEIKFKLPSKHEEIQMMLIEVIQCLFKELKTYCKEIDFDYENILLYGFNKILKIISKKFESKLQIKRLIADLKNMKELYYLLFNVDFKYFYQYLKAIFEEQIELKNNSTWINHPISHALLERSSEYCLEIEENSKSIEYCLEMEENNKSIEYYLEIEENNKFIKYKTNESNNKEEYEPTNSDSQTYLQISDNQKSKRIKETHFKQESKCKNNFKCKFSSNLKINKLIELIIELSSKKIVILAPNTFISECLIDKIKNFGLKINTEIKTKTENTIFNFLKPENKQETNFITVLTFYDFLLCEINYDFVFFIENDLGCIRKIETWANKTEKNVCVYLLMYKDSLEEQKYLMEIRNEKDCFVKLIENYSTMSLDLSKEIAIDLEDSEEEIREYKVYIDFREMRSGLPYFLYKSGNKIDVMALEIGDYLLGSSVCLERKNILDLISSLNSGRLYLQLKMMEHSYTFNYLLLEFDNGRRPCLSDYFNFKEESFKNSILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR7</accession>
    <name>A0A4Q9LYR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0296p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000296">
        <property type="protein sequence ID" value="TBU16546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0296p0010"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="4">
        <location>
            <begin position="369"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU16546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="63313" checksum="0F8DD30B55CCFEED" modified="2019-07-31" version="1">MEDFSKNIFFNEKNRMIKISEYENIKTFSYVYTILYFILAILFGVGGRISYNLIEEHKEISLLMFHIFVYLSIYFLLSVVMTLLCLYLSKPKYNGTFKQILVYKNSNSIKFIFGLVLYSMLIKIMSLLKSFHYYDFESINNLKFKFLPKNEKSFSEFIFSFSLAIFTFCLHKIVYQYAIYNMHYRFYRDKLHLIRNQMRVIERIHNVTNQKFSSNIDKTSSEIFKQLSGDTRNITLESLKIHFDETDSQEILNFFSEEKTNYDILNISRVSNINDDANIRSNNQIQIKKRVFSEKYSNLASNFNKLSLILIQNEKNFDKLRTILILVFIPISICIFYVSMGKKDLFRGYYMGVLGLILPMAFVFGPICSEILSCIIFVFFVRPFDKKDTIEIENEQYSVKEIGISYSTLISDSRTCNYPNEQLRKNRITNIRKSSYNVFTISKMFSYESFKENFDSLKTRIAKYLKEHPCDYKDEFYITDFEITKECHIKVNFILYFYISHDDLRIQEKRKDNFTLFLHNLIKELNIVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ0</accession>
    <name>A0A4Q9LYZ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleotide-sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0256p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000256">
        <property type="protein sequence ID" value="TBU18008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0256p0010"/>
    <dbReference type="OrthoDB" id="2191964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36617" checksum="7311196FF23BB717" modified="2019-07-31" version="1">MNTSIMKAERNKYLQILQKYIAIVPIFIQATINGYVIRKFTGRKSSSKCLPILMVELFKLIISSYMKTKQPVDYNLDIFTMGIITFCKSILMWNFVYRLHPMYFSVCYQSRIIFLCVISYIVMKKRFFIYQYWGQGLIFIGIILPEILKNHIKSKSQNVEVITCLAIITAGFLNSFGSVFFEVKIKKKVQNFWDYTFQYSVFAVIITFIGCVVEFYTKEIDIISNFESLFFWLAIILNSLGSMVASYLALILCPLTRTFLMILSSAMSTTVISLLLQNKIQPINIFSLIIVYTGTMIYEIGNTKTINNKKNNHDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ14</accession>
    <name>A0A4Q9LZ14_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0509p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000509">
        <property type="protein sequence ID" value="TBU13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0509p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16282" checksum="3D998D22E8E688A8" modified="2019-07-31" version="1">MMRRKNFFEPLFENEKFENDKMNITFNLPEGVDPNNVEIKHEKNAYHMKYKTETKDEKDGVSFSSSSYGYFSRSFPFEIKNPHAEVKENKLFFSFDRGEDTSGLKSIPIKNGNSKEKIVTNKKETESNASCSSGKCQHCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ29</accession>
    <name>A0A4Q9LZ29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0247p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000247">
        <property type="protein sequence ID" value="TBU18235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0247p0010"/>
    <dbReference type="OrthoDB" id="2190279at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="244" mass="28386" checksum="7F7DF01B926736AB" modified="2019-07-31" version="1" fragment="single">MENFTSTVFCVSKLKQELTLPHTKTVILHCGKQAIKSFNGVPVFFVSFYRKNFIFFQISPYKEIKSIVYLEEFKNYTFFNDKICVLKDNSVEHLDGEKMLEGDFSQFTDIYMINDNIVLSGNKYLKIFEICRNNSENEKKVFSVENIHSYFIKCDCFFIGYAVTLIGRKNLIDIKKENQLLGTLTFPENITSVISDTLVTKVYSGSESGKIYFSSLEDNNCLEHILYFHESSIIQLKMSFCEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ40</accession>
    <name>A0A4Q9LZ40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0241p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000241">
        <property type="protein sequence ID" value="TBU18432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0241p0050"/>
    <dbReference type="OrthoDB" id="2200980at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="31032" checksum="7E6A22FDD7AA88D8" modified="2019-07-31" version="1">MLYEYGNGRRKKVDSENIKNEKIKAVNNLENSAGEILMCDVDVAMLSERLPPPTTFHDTTHQPPSSSFQTSLFCLVDTIPSSSGTDATAFGPANGMTNLNPDAILEGNRLIVLHSILDSVTVVEQEWPRYAILAVQKRFERMPRNGWPATLRYYNEEFSCTLDIDAFKKLAQNEAEREIRQEENGERRRIATCLTEPCTLTDTTEYINLRDKFLSKIKEISENEIRKMVVRTRKLPSELVDSKILDLINRINGEYADSCVPMTITAVARIIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ91</accession>
    <name>A0A4Q9LZ91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1037p0030</name>
        <name evidence="4" type="ORF">CWI38_0234p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001037">
        <property type="protein sequence ID" value="TBU00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000234">
        <property type="protein sequence ID" value="TBU18633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ91"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1037p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0234p0040"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="147" mass="17036" checksum="3DB497018761A115" modified="2019-07-31" version="1">MPPYFHRRLQKEIKTLIEDPLENIRLVEFKDIRNLKLEITGSSGTLYEDEKYILSVKIPESYPIDSPEVIFSNTVPLNEHVYSNGHICLSILYDQWSPALTIKSVCLSIISLLSSARAKKKPANDKLYCRISQNRSPKSFKWEYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ95</accession>
    <name>A0A4Q9LZ95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0229p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000229">
        <property type="protein sequence ID" value="TBU18743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0229p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="678" mass="80315" checksum="413CEEC28C31041F" modified="2019-07-31" version="1">MIYIDLIYMMYFLDLVRGSDVNDVRRPPSLDFIFQNNQYSRQIMRPRLYSLFHSHGTSQSYPSDTQTYQFNPRSFFSDQQSYFTTHQFRPSEQELHRLKRPNDLSDQELQSLNPQPHHFDQDLQSSDEQYCLRNSNSSENNQISSHVAANCNKNTNFISESPPHNSSSYYQPKNKLVRNLAQSYRPAIIFKLFPFYFQSNSTIEQKALTDVKPIQTTHFTQPTSLIQNENSKIRFEENSLGFFHLICNSLDNQQIKKDLDVKYEDHKYWSLREYNKAKISNNVSSGSEINELDECKPFLESNYEIFLEDISHSKEEIAIFSKNMEMYTNSIIENESQKIYSGEKRIPELKNSIFRVFVKKGLPMIYLKPIFLLLPYWVKTALNENNSKTINVFYLSWCLKVIEAVIEFYSKDLNIYISDGSEGNKMKEFSHIFSFNITAFYNSYNFILDYLKNICRIFKKQYHERFFEVVSDVDFLYSHCEEVLCLEYTYSLIPGMPLISLLPKKQVIPEIAGILFDVFILLSDESLKTINIKILESNYLNQEPKNQYKSFKTHFAKKLSSESYSIEADIRDLFKDIARVYKIIFCDYFTMKIFEEDSSELHEKFKNWLPNNYSNLEKLNLRNIIPKYNDYIRFFETCNMLLHYICKVILNPSLTPKKYKTAISLKIRLKLQTEIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC2</accession>
    <name>A0A4Q9LZC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0223p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000223">
        <property type="protein sequence ID" value="TBU18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0223p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="29873" checksum="60D98C5EF8ACD806" modified="2019-07-31" version="1">MLFWKTKEFRIAAIVVFGITTVCLIIGCIGYYKAGNAIKDFEEDFKKVSETLQFKNNLLEFETIRYAVFMNSIKYKLFMICEIHNNNIPLTKPFEEYNRSNISEPIKDSTKKFLTKIRKAFESSNLFSFDTSGFLKVIPNLGFFVRIGLLIRKKHPFLDVYRAFKSIGSLLNNSLGNEGPLFIILKIVDDKRVLLNEKYLYSEITGIFCVKKILDFDSLKINGKKFVSSDFIIYIAEKVRTESKDIMDELRNNYFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG5</accession>
    <name>A0A4Q9LZG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0359p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000359">
        <property type="protein sequence ID" value="TBU13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0359p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020867811" evidence="1">
        <location>
            <begin position="16"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="386" mass="44695" checksum="D1678B0845288139" modified="2019-07-31" version="1">MYLIVFLYLQLYLLADSTCESNICFYDIDICGHQASSEKRSSMSAFETNRSRKAKTEALKRLCVRGDGYNSSKKSKKFRERQQNSDSVCNPGILVSSQIVSSSTDKETTQLVENNRLNSTDLEIPASKTRSFPELERQKAKTKLRKLFSYLLKDNKKKIFKKKRKPYVRIELNSKQKEIVNQNFSNACDEIKKYITDNILTQKDEILDPTDFEYFEKKEKEILNLRIPKTNRILFISTDGIYSIWKSKILEIFNNAPLFLYSILPEILSIKNLVKEDSKSIKPQGGNYLVTLLIFEAIVGNPSLNNEKINMKNQKIEGFTDLTMCSQSLRGISAYLRMLLEDIERMMEILKELKNTYLPAESDLSLLHSVEKESMEQLRRRNNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN7</accession>
    <name>A0A4Q9LZN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0203p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000203">
        <property type="protein sequence ID" value="TBU19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0203p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="585" mass="68782" checksum="BBDC007EE7C0CAA3" modified="2019-07-31" version="1">MRYAAYIYRICFLVTIFSSNVYPAIPTQLYSVANIQNQQIPRILTYNTEFSRPEHLHWPHLITFSQPFVYNTYPLPPLQRVLVSNYQGSMYPCIEPTVSPSPIFLPMNPYIRPNIPVNLQDSLSIPSMIPGQGFVFAQECNMVTNPMPPSIQHLSNQVNHNPSVQMNALIERIGKDENGCLKNDMFQLLNFDGHCFIETNRLEMLELLESLFRKRWIHKLESMYPLLENNTKLILNNVFDNKNQVELIGENIKWYVKKILRMRKYGIGFGCNLSKMFSSNILSIFYTDNLPFIYLKPIYLLLPSWIEGVVYNDVNIRNNLFYISWCLGLMKAIMEYNYGCLKPFISQNLEKDERGAISYLYEINKEIIYNLNRYLLELSKNIFEVLNKGIINEIFEISADLSCYPSHCDRIFSIKYIFSGIPGIIFDVFIFVSNENLEFLKSIILEYKTMKKLPENSDIELDIHMKQKLDYNSYYTSQNVGSLFYNIARVYETIFLDKLFFINRIKNSHFLEFDLWMNKNISNLTIKITNGALPKYYDYIMFLETCNLFLHYISKIVLNPNLTPKTFRDTISQKIINDLSQIYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV7</accession>
    <name>A0A4Q9LZV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1425p0010</name>
        <name evidence="6" type="ORF">CWI38_0180p0010</name>
        <name evidence="5" type="ORF">CWI38_0198p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001425">
        <property type="protein sequence ID" value="TBT99199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000198">
        <property type="protein sequence ID" value="TBU19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000180">
        <property type="protein sequence ID" value="TBU19884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1425p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0180p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0198p0030"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="232" mass="27470" checksum="BE37CA0266F9E0DD" modified="2019-07-31" version="1">MNSKAEKYKNLATTCLSKKDYKGYKTNLKYVYDITQNEDDKIMLEKAVKMYQIYLDIQEFLKIDQKDYYAVLGLESKATHDEIRKAYKKLALKYHPNITKLQESNEVFGRIQMAYTTLKDEKTRRDYDFSRIYSRNTTYNGSERITPEHSFASGFHSTTPNPYGYPSFHSFSSTGFISPNEYDFYRAFYQMTNGPTFSTFHRPRRNNTQPIQQNDFKVIIFIIIIFLFLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW3</accession>
    <name>A0A4Q9LZW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0419p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000419">
        <property type="protein sequence ID" value="TBU13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0419p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="50243" checksum="59F0E8391F0A0ACF" modified="2019-07-31" version="1">MGSSRQKIYFLEKNKTGLFIFNGSILLFIILGLCITVLNANRLCKNLQKEFIEFENSEIGAQVLKTCNGSDQASFGFAILKNSKKIVFPLGACFKNHEAVQKEIRILNEKFYQVLSEEEENEVSNLSGTNLIFLPWFFELDSLKEFCEKYKPNLFQRIGLFFFNNKNILFFLLKYIESLDQAFQKKAEIFGISEQCVLEKTMKIKIKWIKTSFLCLESLFQDISGTDIDFRNDRKLENNPHVFFKEILKLAGEYFIDGVFSSIFLRLNLFSRYTVKSHPKINNIISKLKDKFEEDFIRIQVEYKQSRNLEYICDFQEDLSSCVTQDDLGRSKSKLDIRRRKLIEDYKDIAEYMVVSFLRKKLLNEFLESEIENKRVLKFLVEIYGLFVSGESGAVNTIDFIEEFAFKLILRNWKILRSVISKLKRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M011</accession>
    <name>A0A4Q9M011_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0444p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000444">
        <property type="protein sequence ID" value="TBU13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M011"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0444p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020588522" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15409" checksum="28D101FB70A1604D" modified="2019-07-31" version="1">MHFKTQMITCIFCYLSLFTSVMCSIDEEKPGSESQVLQVPAIEADGRQLLEATQDTEAVEPKEAVESTEAVKALNIEDREQETKKILDEVKEKESQGEGVVRSGEIKDELDRYANPQGYDVEEHGEANEGRSSPCGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F6</accession>
    <name>A0A4Q9M0F6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0398p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000398">
        <property type="protein sequence ID" value="TBU13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0398p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="818" mass="95636" checksum="16A87CC4B2F9321E" modified="2019-07-31" version="1">MLKYKVKIQLRRYCYLIHCIKFIFLEVIVCASSHDSGVITFGLIDRDWSCKYPEDVDYKTVKYWLVSTENGTSKLCTGDHCVKTIPIRESTAYQYVFSCTKNATFYNHEPLHSYEVIYLNRWNVKFRVLNNLLNNSKPEPFIFESYLKIYYQDFYIIDCYLNPRIDLNFHNLPYKLFYKILAVLTSLDPISSKYLNQVYSNLLKNGLMGFESKKILADPKNYKMKYLNSKKHIFMYFFSVLYDTIDACLIQQKSLVYIFKRTEDCIDQCFKDIDNIAFIRLKVTIYSLDVISLNFSSFMWSVFNWLLSLINISGLYIDESEIVYYGIKVPVLYHSNAKDVVKNIESNKSMLNCKFFESLCSATLQNISYLRFDNLRLSFYLLSSFLENNKISHFELSFCSFDVADTRTQLSKILEKISKLITLKLRGLLLWESDINFILSSIIRYLVLYDCTVVTGTEKAPNYTYRPAYKIYKTLTHLDISFSKLPINFVSALLCSDSLENINFSSFEFSKDDFVSLSLFNFTKKLNYLKIVNLTTNDQLFRFFEGIKSVHTLILSKISNLANLDFFLRLPNFSESVVTLNLSNNFLSVAILNLLGKFNQISCLHLENSLPLNSEELDEMPLFRTLEELDVSHNEFKAIGNNFISRCLKLRKINISNSKFHKGALMCIFTNNLVNNLLHLDLSGTELQHGDFQRVCECKLLQYLAIDFKKDLVSFPYELLMYASFKMYLNFLIFAVEKIEILDFINLVIEFPNLKKFRILCETLYVARDKHLQLSLGSYNAKSFCYIEVLYVNPISDCIIEFLQSTSIFHSISFFNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G1</accession>
    <name>A0A4Q9M0G1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0257p0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000257">
        <property type="protein sequence ID" value="TBU18007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0G1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0257p0030"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU18007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="42768" checksum="F381D718EA933B00" modified="2019-07-31" version="1">MRFLTSTAHTDSLLFSIFRKPHTISVLMAMLSMLVYLAFFYRCKSNVVTGLLVSFIVFVVVGTLFYTDGIFERPHPVLWRGVKACSVYYLMVMVFLLFQDKHNVRLWLKYIDPSLGVPLPERSYATHCDLTFTNLYNQMDIFVVAHIFGWYFKAIIFRDYFLCWILSVMFEVMEYSLQHQLPNFAECWWDHWILDVFTCNALGIHLGIKTCQYFNAKLYRWRGNVDPGFVIYEWLKGATTFKNYIGILILVIINIAIELNTFYLKALLYLPPSHFLNVIRLVIHVLMGAVALREGYSYFSDRSVKTFGSQVWICLACTLVETLVCFKYGKGEFSNPFPRNVIIFWSFLMAAVIVYPILRYKMRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J8</accession>
    <name>A0A4Q9M0J8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0248p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000248">
        <property type="protein sequence ID" value="TBU18234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0248p0050"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="40266" checksum="6AB176C97442191B" modified="2019-07-31" version="1">MKVGRAYFTLFISFLIFELFQKIFLFYSQKNVITECTEIKNYILYEKRYESAKRSIVGLKNDNFVCYFNSLIQALYFQNDFMKGLFLYEHTKEQRCIFILKELLEQMLNDRIVNTSVYLKEILELDSNFEYFKFGCFEDAGTCLDIIFLRILKEIDVKKFSDLNNVTNKYFPINLYLFQMKTTYLCVECLEKNIIYGDNYNLVLYLENSIQESINKSFNVESIQCYKNKFKDEIHYAKILREFVNLPSSIIIKNTHDPSSNGNVWIDEEIIVQNQKYSFKACVFYVKDLHYYTVAVLDNNYYELNDNSVKNLNIESIENLGFSDIPDILFYEKCNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X0</accession>
    <name>A0A4Q9M0X0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0106p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="25414" checksum="F8CBAEE56562D94D" modified="2019-07-31" version="1">MYWKEVSCLSEVLLKTKKIHAKISRTYNSLLSTTRLSTFLAYILFTGFLRTYICVRITINFTNESCLKDVVTDQGESHIARKSHTITSHISESDCVSYHNQISFDPILKHTNEERTEYPYNSYNKRPRIDSCVESAYNKENKTINTNLFNIRKEGLFVDGMARCDKNNFIQHPLNTLTFDYSDNYQIKSRYFDRFNKPELNEICLNIKAITKSNIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G7</accession>
    <name>A0A4Q9M1G7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0063p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000063">
        <property type="protein sequence ID" value="TBU20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0063p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11871" checksum="19B9F670EC05F6E9" modified="2019-07-31" version="1">MEYNQTEKTLEFTEIYQSIDEFLQNTNEFNNNEHINMLEFLNDMKSIISNHHVKALNTASAIGLYISSRYLVRKRSQLKMLLVTDGVMGEVFMSNQNRFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L5</accession>
    <name>A0A4Q9M1L5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Dicer endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0045p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000045">
        <property type="protein sequence ID" value="TBU20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1L5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0045p0040"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="7">
        <location>
            <begin position="429"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="6">
        <location>
            <begin position="852"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="6">
        <location>
            <begin position="1079"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1241" mass="146139" checksum="835DB51415AFE375" modified="2019-07-31" version="1">MNSIIDNNSNNIRNEIFLENEFTTSEIKKYIHDFDRILLIVEQTSTEKYDEEVIDLRTTSVYDIIYQNTIFPKIMITPLKFFYLSKHGILTTEMFDILIIRLDEIKKEFSSIFKHFYYLKIRDCILNGIPNITRPLVVRSFLRKINYLDPIYLHSKINNSNVSNNKPSIKLYILESNVDENVLKYIELKKIFESAIKKETHPQKIFKFVEIIKNISFLEKISYKLSMDLLNNGHNLDNVDVNKIKENKYIEDPKYLTIGNQNDNNTDNILNNNKNTEENNILAINERKYQKLKDILKDNSKLDFYISTTNKFVVEILSKTYKNIFYLDEKVSNINFENSILVFYEYINIEMAAKPFKEIFVFNRADAPLKKFIEIKYLRNSCINKESDEDLNNNLMSNDKKLELFNYLKSIEPELYIPPTSAYVSLDSAFLILTNFFYLLKNVFDDNFLFIRNLSIQSKYESQPSGFVCIIILPRIHNHFIFSNIHISKVYPTKKESQKDAALNILQSLYDEKLINDYLLPITTRFINENFVYFDLVKKIYRIDISNDILDLRNKLNEIREESFQLFSKDPIMKPEMFSLAFKKKYSINLEINNSSERTCDISTFHQLQPKCLSFYPSIYFLYVFNEGSESDDDVGICCGESFIESVNFKGIEIKFLKSVRFSSEDLFYLIFYQIAIFSLYFKKTTTSSEITKDYCYYYVPIKNGSVNMNFIYNFSRNFLRKNVYECELLNLKEEIFFNPFSGFFYTFKNFCNFSIHSKKNFTSLDKYESLDDKSISFYKYFQQKYDIKLKNDPEDMKLLFDGTLYSLKGETSVINTLSSELVRNTGIKKSEFFKFQKFKKYFYAFESVSLAFELKNKLGICINSQLMSQCLSLRSSSFGNRGVEYDYERLEFLGDSVLKFIVSKHLLLVANENLKYIVTKKDSFISNDHLFEIAKKLSIPYYFSFIPYCDKLFQAPNIFMYLKDCGNPEYTNKLFELLKIFKTESIFQNNDQSFYLNRLLNKKNANEKEIGKFILSKKTCADILEAIIGAHFIEFGIKRASDFIYKINIIEPLHNLPEKNSLIEEMCLYKEILKEYEIENVEKILNYKFKNKGLIEKALIHPSSYSNVLGSIHFNKLELLGDCILDLCITRKIFNENKNLDPSGLHSLRKSFVNNYSLARALFKSKLVWHTHTHFSKDDLHQISLGLIKDGNKVNKMFGDLFEAVCGAIAIDMNIDFDIFETYFNKNFYDVLNVCVDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M5</accession>
    <name>A0A4Q9M1M5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0044p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="24925" checksum="AF44A9E0793FF814" modified="2019-07-31" version="1">MDGSDSKRDDLIKMRVSGDFPIKSEQLELYSPVLQIRRLSTIGKRNIVVTSIVFYYQIVCKGEIVFDMFHYILIIAGIVEGTMLEGKSSTAKMPDSEIINLGYTCEHPITYVKNKNPNILEYKVKKTIEKIESNFDEDFDYNGYVKRNNIFPEENEKKVFSELKTYDNSSEKQGNSLHSSLDNSFTDDIIFNNKDAHPGKTVKRNSKKQIIFYPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P6</accession>
    <name>A0A4Q9M1P6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0046p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1P6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0020"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="12662" checksum="85540D41E6CCB440" modified="2019-07-31" version="1">MTYTIKKIHHDAKVPHRQTSGSAGYDLYTCTSGKIAPETTAFIHTGILLEVPYLTLILPRSGLASKHLIDVSGEYIPPNKLQEIVVCVTNYGKEEFIYNVNDRIAQMVFTFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R3</accession>
    <name>A0A4Q9M1R3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0274p0040</name>
        <name evidence="3" type="ORF">CWI38_1484p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001484">
        <property type="protein sequence ID" value="TBU10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000274">
        <property type="protein sequence ID" value="TBU17653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1R3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0274p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1484p0020"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU17653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15527" checksum="BFDA79BEF0E67176" modified="2019-07-31" version="1">MSSFTLTITHTIPNPLLSRQLIKVKLAHPNSSTPKKDEITKKLAYLFQTDPSLVIVRNCRTAFGLHETTAEAKIYEEISTLNSTEHSYVIARKTGVVADKVPRRLRKDTRKKKYKMFGSLRRNMRVAAKKEKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M251</accession>
    <name>A0A4Q9M251_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0026p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020342508" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1530" mass="179337" checksum="EA4EB57FFB1898A7" modified="2019-07-31" version="1">MKKTFIFYFLFLKIERFIHCFADPENIIFPIGDLTDEEYLSEFNDHNKSILWYSVVPTKNIKNMLFYIKSEDRDVYYSIIRILFMRNDVNCRYIDVLLVSYILKISFLQKCNENANNETFNSETTKNSFLPIEKNKYVIMNYEKYVEVEICFLTYRRTLENSTSDFYDFKREKICKYNFRKSMLWFLKNNIDYILNDKKISEILSQDIFLAIYDCIFFIVMKNNENGLKTFNEDSLHGKIITDKHIKNFITRNVNIREFLDDLQKKLNDTNIIKSDDIPRNYIETIFLMNESYDIDISRIKEGRCFLAILNAASGLHESENFPLMDTLKIYLIKIYNEILEQRLLYLNTTNTEYIQSKCWSRLEGEKILKQKDDLSSENLEFIKIIESTFKIFNKFLIKYNICHNIYQDTVLKPEIINSYVILKSFFLNSLQNYEKTAEELKNSHSKKYLDVIIDFVNNFTGESGLKLKLECEEIFLISLKTLVCLYNSKKEIKFFDSKEITRLMTFYNTVKIKNISDSQEIENMIKQINKKIDLSKREKFKSNSEEFMACMFIENILTKFLEYLNSSNIKQSKNHINDCRESASLNFSNINQKKMLKASFLKNDINYSDKMHQGGINSSNINQNMIKVYGNSIEMLNDNFDGGPISRTLFKSTSYIEPELNVWKEKRNEDMDTLSNITNNGAIDMEISMASEKDLIFINQKYLPCKFIYTNRFSLRNSNAGKFSREENNILFSTEFKCTLIDFVFLSSENSVAKETEIIFENQWRRYFEKKIKETTQRIFKISKTCDLSRQQTEGYIFEYEIDADYFNFNFQRSKGESIIKITDTNLSDYSANIFDFKNAIDLKVLEVIKLIETAIDEFFEDLEHFTIIKLVEFIKKYYVKMGYSIQDSNKSVSFYTDSNIESTVLGLENGSLTISDSEYNMSNHLESNLYQTIFSNKESEFMANDVDKSSPYDKFTSDKISNILERSPALFHDSKNSQDFFCLTSTQNQNVKFAKFEFKDCSSIEDSENENSFFELCNLKSNSIYNSGTTSKNDQAEIRSNRNTENFLRTHNSINTEKQIESSINNNISLNAGKINTKSMHDLNGKESSDHTIYTTPDKDVLVSKNFLISHSNFDKKSNLPNDKDLNRYSKRNLSHMEERSDLKNGNYGKNRTSSRFYNNILNHKKQSKRKWEGNKTHTSNGSEISVFSLKNHGLNLNGTNTLERQKDIIHPQDVDFLNFNGTNNSGGMDDNFESVSNNSSISNRANSSGEMDDGFVLVSDNSSISDRANSSEIDDNISLKEDKNLGSYEPNRLLKTSRFSRKNVNIENPFESTNVIEETSNREFHDNNLFSDSEIDNNLLSRINISGFNKSDLSRDSANEYIASREKTLRSFRNMHDGNKYSKRSENSKENHSSSDCYASSIYSNYTSYREEFENNNTRNNAHVPNRKLPSRKLSQRFKISNKITNIPHKGLNTLKKKRRRYENKTNSYSSLEADRDISKVFREALNVEKVRNRNKKLLHILYFINNMLFIALILTLFWYFFIKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M420</accession>
    <name>A0A4Q9M420_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative U6 snRNA-associated Sm-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0065p0140</name>
        <name evidence="10" type="ORF">CWI38_1318p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001318">
        <property type="protein sequence ID" value="TBU11217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M420"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1318p0020"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11894" checksum="5884E8170F43C7B6" modified="2019-07-31" version="1">MMFYMYFKSFVNKNVEVVLKNEIKIYGVLLSVDSYLNCKIKIDKIENADIGISNLIICYIRGSNIKFLWLKNDLERMKGLMDASRYRVTMCNKSTNKCEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4A0</accession>
    <name>A0A4Q9M4A0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0068p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4A0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1061" mass="122238" checksum="61D37ECFB038153B" modified="2019-07-31" version="1">MNYGLYELYLYANIYKHQNKISSPDKIFSNTPIRTDGIEIITINHKLIIAETFELSTSAIPGYKINLIKDNKIRSKITKRIEKLKKLFEEEMPLRNLKHVGLEACEVEKIINLHGKAQPRTNLYPKDLIDKFVLDGRYNKVENTIQEIEDYYKEVLNNIKSLKLGKSEEYRQQAGFKTGHSSLNPALALDTLLRHSNGNMINVTLYIKKAYDSVDRNKLYWKLIKLQKFSIRDTKLIAHLIENNKYTLCSNKATSLVKTASIGPPKDTVALKGVLLHIGARIINTLYVRATTVRDKSILKGIPTTIFKTFLDIIIPEHKRENIIEILVKFIQHNIDHPNLAGIPTRDVTAIFKNFLPDNILKLIRADETVVTGVINDTRRRDTGIEGHNRIRIINKETGGNNKETTTDLSGNSQPGNTRIPSKEHIENIKVSRNNKAFMDIKALLIKNESSEDDNTEKKSRAINDNNEEEKNKVVEGDKNILNTKWDIKNSKVTKESDAVDTTRLAMIEDKNGIFKTEAKDNERIREKPISLSQPRNTEELKRITNEDRKDYDISTEGLEGLIRYSERLEPRLKNEDKCKEQMKYKTEVAITSKNKEHKPIMNISYRLNNTKLNKEQKILITQGNLHLHSKDVVNMVFLSKTVLEVICKEGKKEAVNRVFRNIGARLLKNSPEVDSNGLFKISGFLARMKRIKYRKSNNNYKLRRLALHEVIESLNIKANDIEMDNVLTEPRKLTSYNTEARRNAKARNNNQELFDRFYRDFMMNQCQEHVVENTYKLNPNKCFYNASTEYECYIVKDISLITNVQIPKKVKTIRQKAVKVAVIPYKILKNSEFSRETKFAHLRFRAYKTFIRPHIDYFSQLLGCNKTSSKEQIENRKALQIPIPYAIFPIEDSTQRARRLRGNIAHKIINSRKTLLRHISNQQTPMKQDNVEPQGYKAHMKLVVTGDNYHLEGGNLVATIKGVLFIMLLGGVSIGDGLKGVKYDTATKWVLVYRGVKYMTSIKRVVSHWTVVHKGLKLSSKGVLTYKTSTKGVLSSFSSIYMQRGVSCMQFLNFLKILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4R9</accession>
    <name>A0A4Q9M4R9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0050p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4R9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4R9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0030"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="609" mass="72518" checksum="FECD6DA8B7266DE1" modified="2019-07-31" version="1">MISYVMAWNAIVTKYHNSYLKRLQIPITLEKTVETIFFDRRGGPESRPRTNIPLKKWIYKEDGVNHIQTKNNTSLILDREPTIIINEKSNMRKKRWWYKRYKKMHKSKKTILPFKNEIVDIILDSNGYAYKNQITAVISYDDEEIQSFMALLSGEIENNEWTKGIIKADGTYREDNDWIKNYIFCKNTNVFLAYITVNDAIKFCFLFKGNHISSLEEIEETLKLFKLFRIRNNKIEQLSESETNRLFLARIYILEQKVVFISNVFKSSLSNKRSRNLFCKILRQVSNTKTVFLGLNKFHREIYSIIDSIVILNKGRTVFSGSKKSYIEFLKKYNIELSGKKFRNLEFLSQLSIQKREKSNIDSTESIFEIQNNYLIDNMAKYTKSQFKNTDSINWKQKSESVYDFSFNIHQIYNLWKEFKNNFFKMGYFARKTCIVFFSILFCLIYFRGTIFPIINETFSVFFFELVIIFLLFYSKKPNDLLANEPSLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNKTVETISFDRQRRLESGLNAEESWERASMGVIMRAEMHEEPTPLLKEARREEDDAKNLNQEIIHPLFHKEEPTINIIKSRIYNKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M536</accession>
    <name>A0A4Q9M536_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0034p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M536"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="57916" checksum="FAB185323BC57644" modified="2019-07-31" version="1">MNKKTKQVIFVIGGSILIFLILGLVMAILNANRLCKNLQKEFIEFENSEVGAQVLKTCQGSDKISLGFAVLENSKKILFPLGVCFKNYKAVNETIRILFEKLYKCLTKEEENKVRKLSADTSLIFIPWVFEMESLKEFCKKYNPNLFQRIGLFFLKNKNLLLFIPKYVESFDQAFQKKPISFGSLEQYIYEETVKFKIKSIEDTFPCPGSSSQDMSAGTDIDFRSDRKLDWLLFFMYKSYKNNPEEIFKEILNLLGENVLSWFSGNIVKMVYFFTVKEVSNPEIEDFISKLKDKTENDCVRIVKEYNQSKNFKCLYRLGKLISDFAIEILWESFLNDENDVSIHLNNSNTFFEWIRNKYYGVFPRRENEDNLYGPSAELMMQVKKLIEEYEDILKYVDKTLKTALKDYKERENMSAITRETNIEVAVSFLRKTLLDGFLTSEKQNMRTLKFFVKIFGLILHVYSDAVHTIDFIEDFTFKLILPNLEILRSVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVE1</accession>
    <name>A0A4V2JVE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0246p0020</name>
        <name evidence="11" type="ORF">CWI38_0134p0070</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="PITJ01000246">
        <property type="protein sequence ID" value="TBU03712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVE1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0246p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0070"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="114"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="215" mass="25407" checksum="87B8EDE90AC24911" modified="2019-07-31" version="1">MNEKLPSEFLNKNDDTFSKFYNEFMTIKDTENLEIEGRIGTIIDKFTNNRIKLNCPHPIILKSNSNYRFQSGVTQSYFEDKICKLEELNFSAVNDRVVLSKGIRYLYEGDKLISCQKKYKEKTIDIYLPGSVYDIRISFNREISVESEKSKHFVKNLIRNRKRKSFLFHEYSLDFTVVENECKDVTNEIEVEVKDFGFSKLEFLDILINLSKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVE5</accession>
    <name>A0A4V2JVE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0268p0030</name>
        <name evidence="8" type="ORF">CWI38_0050p0020</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000268">
        <property type="protein sequence ID" value="TBU03602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVE5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0268p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0020"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU03602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="142" mass="16654" checksum="7FA261C168CA25E8" modified="2019-07-31" version="1">MISNDGDKDKKELIIDAAIGLLKFSYMKRRKMYYGEKIKKNKFQQDVLNSVYEVSSFPSTETRCEIALLLGIPQRSVQVWFQNKRQLSKKREGTKQVKIHSDELIIKDNIESEITNDDEVFDIPSLKLVEIIEHCKKKPEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWG1</accession>
    <name>A0A4V2JWG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2340p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002340">
        <property type="protein sequence ID" value="TBU07862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2340p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="13989" checksum="AEAEE9D90901B060" modified="2019-07-31" version="1">MINNITNLSGNEESLDSSSTEKHREKNNINFEFTGRIHNYDSFHNKIPNMDTQTGLKKDFSRKEEIEQKFNDAIENPDTKTNIICLKIQNDSELSRYMKNGTCKVKGIMTLEIEEDRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX40</accession>
    <name>A0A4V2JX40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1926p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001926">
        <property type="protein sequence ID" value="TBU10232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1926p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="17489" checksum="ABB742768C1F02C6" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ0</accession>
    <name>A0A4V2JXJ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_1029p0030</name>
        <name evidence="15" type="ORF">CWI38_0946p0030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001029">
        <property type="protein sequence ID" value="TBU00369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000946">
        <property type="protein sequence ID" value="TBU11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1029p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0946p0030"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="215"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU00369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="588" mass="69745" checksum="B81BCB0412B05FFE" modified="2019-07-31" version="1">MQRTNMTPTRRKSVKPSTNLPPRFSVSMPRQSVMREEDTKRRDARQVRDRDYQQTCQDIVYKFLVENGYQGVLSVKTLQAPSLKDFQTIFKFIFSFIDSKFEFSQRFEEDIMTILKMYKYAFSSEINRSQLIAMTPHTWPAVLSMLSWLVGLVFCFEGVGENSNLQEENILENLFFDFVCHGYQKFLEGDEDEENLDEELNIKINNMYIDSFNEIEEKRSILKEIENKIENFNDKNEEKLSLENRKNGLLKDMNDLNSAKKLLDEKQKKYENYVNKLTEELNEFENEANQAKIEIEDLKNIISTQKINPCDVRVMNTEKEILIKELENLKPEKERLLKMVGEFENIYVSKVDEGEKLLFDLKGIRNQPLPFLISKEKEREEKMDLKFNSCEQKNDLFVEKGNSPQKSVENSKYLDFDFRICEEYKIIGNTDEYVDTIDKEVIKERDEFTKYEISNKELLERKSNDESACKEMERNIKIMEEKLYSVGKIYLEKKELSDKEQQKSRKELEKIESDLLRLQLDSNNSLLISEQTLQRAKINVDRIIQTSKSEKDEVEKLLANFNENLQSYYKIIRSYMKELENLVPKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL5</accession>
    <name>A0A4V2JXL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0829p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000829">
        <property type="protein sequence ID" value="TBU12252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0829p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="13303" checksum="A5BD517329FECE1E" modified="2019-07-31" version="1">MLNFLIIATVTNVKFVFQVNDRKNDSTGDILPLDEINSNIEYLRVLRCSKGSILAQIVSENTFKNEPIFYLNDIEKYPLRFRKFYVSPSETHQEIILYMEGIYYPGFLYFTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP8</accession>
    <name>A0A4V2JXP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0706p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000706">
        <property type="protein sequence ID" value="TBU12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0706p0010"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="384" mass="44530" checksum="D7E896296CF792A8" modified="2019-07-31" version="1">MDTEGIGISNLPNQIYRTVCKKGVDYNIMVVGASGLGKTTFVNMLMGKNILEMEPFCSMDGKKDIEISARKSYHLMDFSGACSLTDFDQVKNNWNDYENSGLLSFQTTEITIVEKKFKVCMTVTEVDEIGDSVCNIGVWEPILKYIETKFKDYYKQETEKVKSKIEDRRIHACIYFIEPCGSFIKEVDIKTMKGISQYCNLIPVISQSDLLTDTEMSILYENFRNILEKQEIGIFEGFLNNEKDVSEYVLPPFFLVTAQNKYTSHGIVRERIYPWGIIDVDTISFNDFNRLKSILVKNNLFDLIQSTEHFYENFRAKEFSSYFLDGPLMSHDEKRVSVEFLDKLKAETEQIVVLRNNLAEKRKPYEKTIKELEKELEEIGKFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV7</accession>
    <name>A0A4V2JXV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0476p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000476">
        <property type="protein sequence ID" value="TBU13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0476p0010"/>
    <dbReference type="OrthoDB" id="2198293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="265" mass="31589" checksum="615261A77B562FA7" modified="2019-07-31" version="1" fragment="single">YISYIHILEFEIQPEERSEIILKALKDTNLSEYSEKIREWFFTVLYNNVIDLLNTNNPMIFELLERCYEINSKNLGLIEITLYVFKQIKIKDKKKHIKQRIAILYEDFNKIIKLSKDQETDLIHEIFISFYHLILEFSLENQLLDLIPKLYPISKFSLENLKILLHTEISIPHNHTKIKISIINESYKRNILTVELFDKFIITSTFFGPISFYSFLSEVSLFIDIQEFISDFSKNIINTQSLLLKATGHYEIYEKLKNIYLGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY6</accession>
    <name>A0A4V2JXY6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0368p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000368">
        <property type="protein sequence ID" value="TBU13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0368p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="93873" checksum="1972C98DBBF4E380" modified="2019-07-31" version="1">MPNSSDSYPLESNIKENSGNNDQKLIFQSTHYTLDLNNVQIFENEQNEDRNMEKRYPRLYTDPKLLKNTSDNSLDEISSTVHFDSHISHDTLQNYKESYDFKLDCNLDDSKSESKSSQIKHDFIIFDYSEKCIIRSKYFDKVSQSGLTEINLNIKNITKSNIDCCMCRECLQVLCYGWTTNFFNMKNEQFLDYIWFIYDLSCYSTSIALYKLYENLIPFLISYLESESGFYELYSETIQLSEYRNLFLPFLPSLYNSVFVFFNSSTKELLLIDKKQNDARNRFENNLTEKMSIRTTTKTLDIINEDTFKEKTKFLCKLIFSFEINELKISYDDNYFTECKDSNTADSFNEKNAEISKIETCFSSVFNYIEPLQSRKIESIEFERICLSTSDAGFLFSLNNLQSLILVKCQFENHSKYLCTLSAFFLNLKTLRIIGFRLRNSFFNNLNKLKNLTVLDLSWCIYSDSSNKLFMNPLPNLKESRIDYSNFNYKIINCLIKNNKLNVLSLRGMNFSRLRRFEDCAGWSKSYHSLDLSKCKLNETLSNFFSTNIKCKRLFLEHFLDPIHSKKILNQESLYSSTTYISLSGGLLSADLFVCLNNFYKLKYLNLSNFSEGFLEYSYENQKFEYNSITSESSENRDSNVPAVLSNKKASNKELSLKTKFFECLCATDLTISLEKINLAGNNLSESDIYQIELFVNLKYIIISFDDKVFSRALLTYGAIKCPKVETMIIISTNINSDIYNFIMKLPSLRNLELQECEIFMGVLTSYLSSYPIFLEKVILTNTNLSAEDKAVLELLNVNGVEVTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY36</accession>
    <name>A0A4V2JY36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0247p0050</name>
        <name evidence="5" type="ORF">CWI38_0330p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000330">
        <property type="protein sequence ID" value="TBU14199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000247">
        <property type="protein sequence ID" value="TBU18239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY36"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0247p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0330p0040"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU14199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16559" checksum="306A100CD49B04AB" modified="2019-07-31" version="1">MTQRDDLKKKRTFKKYAYKGIDIEDLMEMPLSKFATLLPSHLRRRIRRGISQREVDVLTECQTAKENCVTAEDKPAMVKTQARTMIIFPQMIGNLIGVHNGFNYVPVDIKPEMIGYVLGDFAPTRLSCSHGKPGVGATSSSKFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVH6</accession>
    <name>A0A4V6MVH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2366p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002366">
        <property type="protein sequence ID" value="TBU07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2366p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9818" checksum="87CCCC050F10D658" modified="2019-07-31" version="1" fragment="single">CRDNSLCDNLGRCCDKIRQDVFRRSLIPMNIEGCIQWIQAMGLIKGAEIHKQPKTSFTYVSIEEDLEETTIIMIEEIVQMAEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN3</accession>
    <name>A0A4V6MVN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0450p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000450">
        <property type="protein sequence ID" value="TBU13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0450p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="25923" checksum="6ADEF1E84024BB74" modified="2019-07-31" version="1">MAKITKKAWIGIGIAGAILVVAATFIGIGYAKAGTVLKNFEDDYKKVSESDSFKTILKDLNDVKLADFVSVNGAKFFQSNFVSSADEAKNVDEALRDKKPDVLKNFTAAPAAAFNRVEIDTSKFASLVGDIGFLAKLGFVFRSSGPLKSIRSVSECINKIIKDDPKEKESMILAFISLADDKETKITEAKVADDGKVSSIADGKTFKRQDKGDVNRKPVDFVAFIAEKVKKQQATPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXF8</accession>
    <name>A0A4Q9KXF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1376p0010</name>
        <name evidence="2" type="ORF">CWI38_0044p0050</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001376">
        <property type="protein sequence ID" value="TBT99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1376p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="143" mass="17319" checksum="E4F18AAF72D005EB" modified="2019-07-31" version="1">MSLNDILTEIKNTDKQTEHIFYLHFYEEYKYFCNYLDLQIIPTLKMLLYIQNDKEIIFNLKNNIWRKAKLCSTDNLIFKINNIYFSKVNKYEGLEIILNILNILCIEIEILKKNILEVFYSHRPDKTEKIRKGRGRKKKSECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L248</accession>
    <name>A0A4Q9L248_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-like subunit of transcription factor IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0696p0030</name>
        <name evidence="6" type="ORF">CWI38_0023p0040</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000696">
        <property type="protein sequence ID" value="TBU01493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L248"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L248"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0696p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0040"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="156" mass="18311" checksum="7B37DD1E9006456C" modified="2019-07-31" version="1">MNYEMTSLYRNIIEEVSKSLELDKDETFIDINIIQDIKMAWTKKLKEYTSPPDRDSLYYSNVSSSYNPSEFKSMKRLMAEEVERGREVEARSTVSDDLSLTESDEIKEEHTNNYMMCLYEKVTKSKNKWRCAFKQGFINIGNTDFAFSTANGDLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9P1</accession>
    <name>A0A4Q9L9P1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0134p0020</name>
        <name evidence="1" type="ORF">CWI37_0197p0020</name>
        <name evidence="3" type="ORF">CWI38_1927p0010</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000197">
        <property type="protein sequence ID" value="TBU04005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000134">
        <property type="protein sequence ID" value="TBU04445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001927">
        <property type="protein sequence ID" value="TBU10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9P1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0134p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0197p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1927p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="248" mass="29764" checksum="5F89AACF888ECB74" modified="2019-07-31" version="1">MTIDNFYTILYFLEYFRVKYDNKLRDALKAILYSLVKSNEMNTLDSKNISFHFTKQDYFSHKLYKIISQEYFKIMKFEINSVNPYFLKEKQSYFYNDHEGLYTNDKTHFLIINDNFNVFFCEKVAVNSKSLNLFALLLNTLDIKYLHIPNPNEKNTNAFCFVLENLKKKIDEIIFYLGSIYDKTVETINRNLNFVDLKKIVFIKSKIITNSIFQDHLSKIAEIIFYENKVSRKEYEIIKIMDMNNINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCR9</accession>
    <name>A0A4Q9LCR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit 2 of splicing factor 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2730p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002730">
        <property type="protein sequence ID" value="TBU05657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCR9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2730p0010"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23078" checksum="EB8B381E1B11F8BC" modified="2019-07-31" version="1">MVFNNRINTNNSTNISTKNEELLQKRKRIKKIIEETSSIIKDKYHRINSIGKYECLLCYTLHNTEINYISHCQGTKHQNLLKKQIDTEKIIDLKKNKLSPKYIIRNIIQENKKGHNIQLEYTQSTEKPVFKFINSLEQKVEKYNKENIYLVILCEPYINVGFKIENKKVDECSIISYFNEFEKLFTIQFLYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEV4</accession>
    <name>A0A4Q9LEV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0484p0010</name>
        <name evidence="5" type="ORF">CWI38_1072p0010</name>
        <name evidence="4" type="ORF">CWI38_1119p0040</name>
        <name evidence="3" type="ORF">CWI38_1408p0010</name>
        <name evidence="2" type="ORF">CWI38_2659p0020</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002659">
        <property type="protein sequence ID" value="TBU06015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001408">
        <property type="protein sequence ID" value="TBU11059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001119">
        <property type="protein sequence ID" value="TBU11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001072">
        <property type="protein sequence ID" value="TBU11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000484">
        <property type="protein sequence ID" value="TBU13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0484p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1072p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1119p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1408p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2659p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15549" checksum="7BEC25BA7511952D" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQYIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF44</accession>
    <name>A0A4Q9LF44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5099 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2640p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002640">
        <property type="protein sequence ID" value="TBU06115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2640p0010"/>
    <dbReference type="OrthoDB" id="2189368at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031503">
        <property type="entry name" value="DUF5099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17025">
        <property type="entry name" value="DUF5099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="16114" checksum="F7945002B911408C" modified="2019-07-31" version="1">MLKRILQRINNPLLFFKKVPKYVLIIDNYNTFTYDLLLKMKCILQIEKLKVLVDKEKNEFDLENSKYNINYFYDNTLLPDMIILCNDIFSFKIENPLLLSRAEIWFSRYKLNENTFYQAYWHYSDCEIRNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFM0</accession>
    <name>A0A4Q9LFM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2680p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002680">
        <property type="protein sequence ID" value="TBU05921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFM0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2680p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="492" mass="57242" checksum="BBD1EFD7C4E6994A" modified="2019-07-31" version="1" fragment="single">NTSNYHPFNNNTTKQQGVNNNTSNYHPFNNNTTKQQGVNNNTSNYHPFTKDTSNYHPFNNNTTNYHPSNTTYLSLIVKYTFSKRKTYFIKILDMILEYILIINTPLYNIDNIFIKICYLLDITVEEFNKEYMYIIAPVIYRHIITPISNSSDISGGINYKNRLEGVNDKGSNYNPVNDIKYNYKPVNNTTHKQHPVNYTTNKQHPLNHTTDKQHPLNNNNIEQHPLNNNIQQHPLNNNIEQHPLNNTTITNTLSPSLSNNTTLPLYNLLYNNIHFILSYYITNNIHTTYILNTHISKIIKNHKIDILLLLISNNTDYYILYNYIDISNIIYRNISVILFKSKMYCNKNICIYCLIRVILGHVVYRLDLLFNQIFPYLECYSNERGCYYRMYYKGYYEEGDNNSREVEEGNSSDILKGVKYSSSEQQGVNYSSNKQQGVNYSSSEQQGVNYSSNKQQGVNYSSSEQQGVNYSSNKQQGVNYSSSEQQGVNYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHA7</accession>
    <name>A0A4Q9LHA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2108p0010</name>
        <name evidence="3" type="ORF">CWI38_2497p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002108">
        <property type="protein sequence ID" value="TBT97723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002497">
        <property type="protein sequence ID" value="TBU06845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2108p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2497p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="92" mass="11016" checksum="4ED6CF30B87DA7D8" modified="2019-07-31" version="1">MNSTKFKPTKRGAEIKNKPDEKSKQKKSVSHLKDQNRKINKFKDKLEDKIDFYNDKLKYFTKKIANKPKEKYSDLKYKGKKFYKKIPKIASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIK5</accession>
    <name>A0A4Q9LIK5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2498p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002498">
        <property type="protein sequence ID" value="TBU06840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2498p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="1">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15037" checksum="A8F92A265142F965" modified="2019-07-31" version="1">MSENSEKINQGGTENQQENTNEINLNIENDLNKETALKNIINQLKSNEGLPSLKKIKKLIKENHDITKISDNSVDLIFNASKSIFLFLVVKSIEESQKKKRKTLMIEDIKTVIKKYKINFLTEMLQMNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ05</accession>
    <name>A0A4Q9LJ05_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2467p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002467">
        <property type="protein sequence ID" value="TBU07020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2467p0010"/>
    <dbReference type="OrthoDB" id="2192717at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29355" checksum="58CFF365D6BF4393" modified="2019-07-31" version="1" fragment="single">KSGKTVDHLATRCEKILGHDYTRRHNEEVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLKKYDLLANELGLIYRCSVEIIPYVMTWDGITRNTHECRGIIQSIVLKKTVETISFDRRRGLEVSLGVILGAEMHRQLILPLKQVSREDDGAKNNTLFISEGGITLDEPTININEESELEEEIEMVEIMERIIKREKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ18</accession>
    <name>A0A4Q9LJ18_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2294p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002294">
        <property type="protein sequence ID" value="TBU08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2294p0010"/>
    <dbReference type="OrthoDB" id="3349616at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="40391" checksum="E2F8002627E3F239" modified="2019-07-31" version="1">MFWDGIRLQIPMNTIETISFDRRKGLDVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPFILDGINTAKEPTTIQMKSWSRKFTLFGDDICFIRRDHLIRAVFGFETALIKQIIQTGHAVPHFEVNKMMALMAYIKEYVKECEACSRFDSLKTIQPIYINHITKKYDLFMMDSFLTDLNIKIIHGRPRNLKAQGRVERVNQTIKRWLAKKFHDTDGRRWMEHFNNFVYAYTRTIHGATNKSLFMPFFRQPGFNNTLSGSIIIDPDMVLILEIASDVHEEFTETVNTTTTIITDDLEIDSKIRLDVAKHFKNYRERILENNNLNRLKRDFSSADQVLIKKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKF1</accession>
    <name>A0A4Q9LKF1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1929p0010</name>
        <name evidence="13" type="ORF">CWI38_2270p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01001929">
        <property type="protein sequence ID" value="TBT98046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002270">
        <property type="protein sequence ID" value="TBU08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKF1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1929p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2270p0010"/>
    <dbReference type="OrthoDB" id="2191713at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT98046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="413" mass="48775" checksum="087C75ED1F6E9AE8" modified="2019-07-31" version="1">MEKDCLMKMYLESFNILEISGKGSSGKVYKVKNTKSNEEMALKEILIDGSKTRLMVLREYLNLSGHVNILKYYKICFCSRLVNIKNFGNFETEISSESDSEDYLISDKEIYRKIKNNKIYFEETYDIKKNIKKYRNSEKSDLNYKIEISDEKYMKENRLNFYDKNSYEKSNNSYETIIKSYDKMSLCDGCNNIKKQDYYFYLLTSYCVCSLRNLIEERNLVYEQKSLKEIVDSKDKIEFNLTKYDINGIFKGIIRGVLFLHKNNVIHRDIKPENIFFIEKEFYVPKIGDFGSCKIFTKSENSSDDDILMTEGIGTAWYCAPESTNSFYSEKIDIYSLGLIYLEMIYPFITSMERAIIFNYIRENGKLPNWLKNDFKKESIIIEKCIKKNPIERISALELFSLVLELTETNKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPA7</accession>
    <name>A0A4Q9LPA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1966p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001966">
        <property type="protein sequence ID" value="TBU10174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1966p0010"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="16998" checksum="1CB3EC90222185B9" modified="2019-07-31" version="1">MTMGKRTNSSVFDDLMKSISDFRFCDDHTIVARDLSSLTLFDTRNTNKELKSVKVFHSDGNLIDDIFESQTAYEKFLVEVSQNKIVTGNFGNKIFILDKVSFATEEISVGEISDLEIVDFSTRIRNIAVENNNIVAALGDQCYFYKNVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPB2</accession>
    <name>A0A4Q9LPB2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1898p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001898">
        <property type="protein sequence ID" value="TBU10259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1898p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17143" checksum="45C321C87CD113E9" modified="2019-07-31" version="1" fragment="single">MYTFALYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWESASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPE5</accession>
    <name>A0A4Q9LPE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1869p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001869">
        <property type="protein sequence ID" value="TBU10298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1869p0010"/>
    <dbReference type="OrthoDB" id="2189981at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="35994" checksum="D712117CAD0C6334" modified="2019-07-31" version="1">MEILKFISGQALSLILSLTALSVRSLNKNTDFIPFYALSMAYIVIHFGGHALNFFQPGNSFFKINILYYIVAGITDFLGGYFQLMTYKELSSYIVVMLSQMNTPITMILESFVFKTNKFDYLLFIEFFVLVIAILCINYFTSMIPIKITFLGIFYILLSDLCYVTNGFIQARIIPEVGIGNYLKGFTLFGFLTGFMMTGYFYRDYVFNIQWSLNFYSKNYLYLFLYTISLSTFYLSASKYISSFGLVAFTASLISVSLYFGNFERLIQQEYNLFSMFGSLICIIFNAYIVYSTKNSILKTSNQDDSPCVGVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ4</accession>
    <name>A0A4Q9LPJ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1795p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="PITK01001795">
        <property type="protein sequence ID" value="TBU10393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1795p0010"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="105"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="26732" checksum="F82ECB7C4E724DC7" modified="2019-07-31" version="1">MVFSLPSLLYQYNELEPYIDTETMKIHHQKHHQTYINNLNTALSKVPSMVDASLVEILLSTNNFTEISADLKKTILNNAGGHYNHSLFWVCMSPNSNVTDMLIPLKTQIEKDFQSFENMKNIFNSKALSVFGSGWVWLCYNTNQQKLSITTSLNQDNPISFDTNLIPFLCLDVWEHAYYLKYQNKRKDYVDQWWNTVDWKNVSLFYDEYALTGHHIRVEADGKIGMRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPQ1</accession>
    <name>A0A4Q9LPQ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1964p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001964">
        <property type="protein sequence ID" value="TBU10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1964p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28681" checksum="4ADCB78C33A5EAE6" modified="2019-07-31" version="1" fragment="single">HDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKQTVETISFDRRRGLESELNAEESWERASKGVIMRSEVHEEPTPPLKVEKREEDAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPW7</accession>
    <name>A0A4Q9LPW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2152p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002152">
        <property type="protein sequence ID" value="TBU09410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2152p0010"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="80" mass="9104" checksum="C63F7A9AE2E81E98" modified="2019-07-31" version="1" fragment="single">HTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHLSKVKLRREGRLLEKYVCSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ00</accession>
    <name>A0A4Q9LQ00_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1762p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001762">
        <property type="protein sequence ID" value="TBU10434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ00"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1762p0010"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="4">
        <location>
            <begin position="319"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="442" mass="50700" checksum="7968F1818E1FB32C" modified="2019-07-31" version="1">MPINICFILELEEKILIIKIYKKNKLKLIMMKGEESKQNKILVIHCGGTFGMVSSENGFTVKKNNVYEIFKKNFESEKSNFKKNIFDGEIREKNKSYVLYKKTFLLKNSYLEIEFKLCELNKIIDSSNVDISDWSMLCNIIDTCRYDGYVVIYGTDTMSYAMAAVSFAIKNTKSPIIFTGAQLPVVIDLKGMDNLIGAIEICGLMLEREMKCNVWLYFSGFLHSGVKARKITSCGFKGFWSRKEKVFGIGKAESIELIENIQNEISKQFIGEEFNLSKNKETLNFFEFILQNSENEKFEKNSVDLKNIGFEQKYKFSKNVALLKIYPGISKNIFEIFLKESMGCVLECYGSGNFCILRTDLLSLLKEYIERGNIVVVVSQCLEGNVEDLYECGNVLKTFGCVLGKWITSEAAYCKLAFVLENFPKKSWKAKIIENLKGEMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ31</accession>
    <name>A0A4Q9LQ31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1980p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001980">
        <property type="protein sequence ID" value="TBU10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ31"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1980p0020"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="54123" checksum="4F01C3DF739480FA" modified="2019-07-31" version="1" fragment="single">MLKKCILFNDSKIKGLNIERIIFLNLCMSTHSMEHLLQKENSLMHKLKAAESENLDLQGALLKIKDEIKTHQQKQKILNNEYIYIVEKHKEYTIIFEELKEMVVNYKEERIKREIYKITKKYNSLLKNITGISFKPTYKIFIDFSNFTSLEEQANKNNFKELEIEMKKYKEYNKQHLLMLITENIKNFLNDPKEIHNLVFYLKFLVKYELYFERKEMSFCIPRILFSDLKKSFYFHFLTEKSTNRLDKPEWMFKHLLKKIESYFKTLQIYTKIYFEELKDENLKNNSDLQINNLFSTEKEFTKNTLNYLICKINTLICLKVRELYKLESQQKRSLVLHFSLEFLKYQNTIEEKYNLISDIPVLLELLIKVQKEFLSQQLYNTHEKTPLGWFKEYFRILKENTLFCNSYVLLDINHLRRENKSLIRNNNSQYSIDSNSSISNFSKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC9</accession>
    <name>A0A4Q9LQC9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1607p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001607">
        <property type="protein sequence ID" value="TBU10689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1607p0030"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29920" checksum="8491B9CC340B8522" modified="2019-07-31" version="1" fragment="single">FCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKYGIVTKYHKSHLKRLAIPMNVEACIQSILLKKTGETISFDRGRGLDSGLNAEESWERASMGVIMRSEMHEEPTPPLKGEKREEDDAKKFKPKNNTPLISEGETQDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG6</accession>
    <name>A0A4Q9LRG6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7769 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1503p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001503">
        <property type="protein sequence ID" value="TBU10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1503p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056671">
        <property type="entry name" value="DUF7769"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889:SF7">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24964">
        <property type="entry name" value="DUF7769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7769" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="9098" checksum="BD9189EC91D7DB58" modified="2019-07-31" version="1" fragment="single">MENVEGNLLNLEKRDSKYKQLTKEQRQGILKKLLQQMKENKLKYGAINEISSAFQVSRLTVNRIWQTAQTQYRKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT7</accession>
    <name>A0A4Q9LRT7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1902p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001902">
        <property type="protein sequence ID" value="TBU10255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1902p0010"/>
    <dbReference type="OrthoDB" id="2193051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11687" checksum="B74886C26F622C65" modified="2019-07-31" version="1" fragment="single">MTLVTSDNQSIDVHFIDNNSDTDIYFFHGAIMKPKVHNKICNKLTKNNKFNIFALIYRGYSNLYKNASSSEIGIMLDIKTFHDYISKNRNTSKKIIIGHSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV3</accession>
    <name>A0A4Q9LRV3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_1287p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="PITK01001287">
        <property type="protein sequence ID" value="TBU11278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1287p0020"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU11278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="396" mass="44759" checksum="084B6AE26FBA8C18" modified="2019-07-31" version="1">MKNRIVYFYDPSIGNFNYSPGHPMKPHRVRMTHSLLVNYGLTNYMDTVRPSQASFNNLTNFHSADYINFLQSVSKSNMTEMFSDLQKFNVGDDCPVFDGLYDYCRITTGGSLCGAYKLNTGQYDIAINWSGGLHHAKRNEASGFCYVNDIVIAILELLKYNERVLYIDIDVHHGDGVEEAFYTSDRVMTVSFHKYGEYFPGTGSLSDVGILKGKNYAVNVPLKDGINDESYSSIFKPVISKVMEHFRPTAIVMQCGADSLAGDRLGCFNLSHFGHSSCINFVKSFNVPLLVLGGGGYTIKNVSKAWAYDTSVILGVEIPQKLPFTEYIEHYGPDYKMMFQYEYLDSILKSITENLRTIESVPSVQMVEIPPNFVEDESDEEILWQRFKEEAGRFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ9</accession>
    <name>A0A4Q9LRZ9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RuvB-like helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1315p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001315">
        <property type="protein sequence ID" value="TBU11224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1315p0010"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB-like AAA-lid" evidence="6">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="28986" checksum="CEE358828B6E9A8D" modified="2019-07-31" version="1" fragment="single">GDVIQINKETGKVFKIGKSSFKKGDFDALGPDVKYVSCPDGELIKIKEDEKTVTLHEIDVINSRTQGYLALFSGESGEIRNEIREEVNKKVEEWVNEGKAEFITGILFIDEVHILDNEAFSFLNKISEDEFCPILILASNKEILKIDTQDGAEEQDIPKDFIDRALIVKTEEYTGKEIESIVKLRMEEENIAIDEESLKYLVDIASNTSLRYSLNLLTFSNARASKRNRSIILEDIKRVSDIFLNENRAISCLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS05</accession>
    <name>A0A4Q9LS05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0423p0010</name>
        <name evidence="3" type="ORF">CWI38_1420p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000423">
        <property type="protein sequence ID" value="TBU02734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001420">
        <property type="protein sequence ID" value="TBU11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS05"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0423p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1420p0010"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="324" mass="37458" checksum="9BF78C98BF5D57CC" modified="2019-07-31" version="1">MDEERTLSTIKKILLEKNVSDPFKVAREILFLYNIAAKGMSYNEDILISCVEKVLSKNDNMEDYKENEEINYYRKAANIKLEPNIVKLRRKSVSGKRANINENDIQFYDKDSQTFAMLYNILEKSLLFQFLNPKQRRKFVWCMAPLTVENNVNLINQDDEGDKMYFVEDGEFDIYKDGEVVGKVCNGAVFGEVALLYNVPRTATVRSVRISKVWFITQGCYMALKIVDEMKKRDFLEKRLGEMKELKFKDKKTFLKVVNGSKRVFFREGTRIEIKKDYFLLVTDDGVINDKKGVAKVCVGDYIESDGLVAVSEIEGFLVPSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB0</accession>
    <name>A0A4Q9LSB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1282p0010</name>
        <name evidence="2" type="ORF">CWI38_1198p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001282">
        <property type="protein sequence ID" value="TBT99605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001198">
        <property type="protein sequence ID" value="TBU11453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1282p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1198p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="134" mass="16089" checksum="34D6DC00F12B3584" modified="2019-07-31" version="1">MLYRLEIYDDLVFFDRISSGVLTSNNHDKYTHQNLEIPPEIYNEIDKNIENDTEVSKHFEKYQKRIIESKDSNKIIRNLFNRNMVLIKKDLRINTKTKRTPFDYFYDDSVFTVTNIFIGNMIELENVNAEKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE5</accession>
    <name>A0A4Q9LSE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1236p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001236">
        <property type="protein sequence ID" value="TBU11384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1236p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="677" mass="81930" checksum="C95D4E2A583EC65F" modified="2019-07-31" version="1" fragment="single">FSYPNDIFLEFEFFNEKLIEKKEEVSIYIEKTDYRILICFLKLLETNECTMKIEPVVFFEFLKYLNIFRVNRNNEYKIFIKLLVFHSIMFNEEYFARISAGFCLCHREYNNLHVRDVIECFFKFYLLSKKFIYELFHKYNPMIFSMRNRLYKKYKLDKNYISLQIEEFEFYFYNHLLNLKFYEIWKVMIGIFYINKFYVDFYTFPRGINLNIVVSSFPPNVRKISILIQHKYLPIFHKLNETEYFKSIKIFKLIIPRLTNPIEEIIRYLKNSEKLTLVFREIEINEIISLESITALEYIKNVKIISLKYIDLHLKHHSSLFLKKKEKFNVDLCCKIELSDFLAASDTFIKYNLNKYIVGINLVVLERTYIPSDFKEIFDFESIKRLKLDFKNVKSNCLENYIFLESFKSLTKLYFSNIKLTSELFGTLLKSNSLVLIWFKMFSFDKEINAESLNILNQSVICMEFYDLDDFLNVHFFYFISKFMSLKYLSITLLFTYNLNRKNYGFEEKIIDLNISHIKKCSHLPSLCSFKYDNRIKCKRSPAFSILHVFTFFFDLDSLEKLVYDSEFLYQEDLETVGNLKVLRSLKLYIYRKNMYGKLLEAILRSNIKETIFELHISVHEFTNEELISILQFKKLKFLFIYTDFFEERNNKYVELLRGLNLIEFKSYLGIGTDNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI9</accession>
    <name>A0A4Q9LSI9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED18</name>
        <name evidence="2" type="ORF">CWI38_1207p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001207">
        <property type="protein sequence ID" value="TBU11434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1207p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17248" checksum="A70F17236D88B44A" modified="2019-07-31" version="1" fragment="single">MILSYKNFIPQKIARIDTYLKSKDHKIILQSCSNSNFLIYKNEPDPTKTLKTIINKINRSEVLNCEDTISFLNLANFKQEKKLFVEGIEYVKDNIHIEVTVHSITNSDIIINEAFMENFIRNYMTNEIDNSLFNSCETFFVKIYTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS2</accession>
    <name>A0A4Q9LSS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1122p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001122">
        <property type="protein sequence ID" value="TBU11599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1122p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="32769" checksum="CA3049488FD777C6" modified="2019-07-31" version="1">MSNPGTQQSAQTSGENNSFEDRNLFKLLVFLLLLSGMILVSVVVVYGNIKSLRKTKKIKEEDNVKDQGGFEKNIDQIPGENKSKPRELNKPEQDTDEYKKDRQGDNDTNEIEREGQEEYVTKEKQDEGTEYEEQEAKFNEEEKIKKMEKEGIKSQVAILHQVVKLKNNKTQKDKNGKNMQVSVEKKSDLLLEHGKEGEIYNGAENAKIKAANENENANIELSVEEKIDIPKNMEDEDFIEILKSVVGEQLNEIKSLKQYERKDIANVNATKQTVDNISEQGTKEQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV8</accession>
    <name>A0A4Q9LTV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1120p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001120">
        <property type="protein sequence ID" value="TBU11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1120p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="52468" checksum="D6B0B24242ED9B4E" modified="2019-07-31" version="1">MHPSLMKGRIFLCFINIFVTVSLLLQIVIIIFIWINIRSICIIGHLRQEMMKLQISNDSLAKYFIQNDSFLLSMINLNNRNVCLLVPIRFTSDYYHETTFKDFLKKDHEYIHKKEVNKIVNMINGLDLKGLKEVILADSLYRNEFLIGFIKKYFYYELPCYKYIKFYEEVSKVFTYSELNTINIIYFTTKSEINIEKIKIKIKKQPIYLDHVLRVDDIKKILNNPDAMKEYENFRKNIANYRDKKHKMIFDKIIKRQAIGYEKLCNLYVNLGQDMKNVLIFGQDFMFPNCADSPSNFVSKIKCLKRKIRKVIISLQIKPFTSSFSNQETLNRICSDIRTLSCLINENSETIAYLALKSSNKLSSLIDSIKRKLDEFNNILNKYFFKYKKIYDFVIQKELIAKALYLFLKKNCEIQPTNHNIQIKYPEETFFSLWLRYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU29</accession>
    <name>A0A4Q9LU29_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0878p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000878">
        <property type="protein sequence ID" value="TBU12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0878p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="95722" checksum="EB9B5819798700B9" modified="2019-07-31" version="1">MNNIMYLKKKRAFKGYEFCIQYFILKIFMTLNLVTAYKFAFNSYKNENSEILFFLQRQENRENSEHNIEKFDLKLYSTNEENQFDRQDLVFTYTKENFIEFYLLNNMLLTNSFENNCQNKIINCNFDLSYYLKLSKDFTEIPDRITICQLKYFLLTLKFLQAVDNKNMAKLLQALIFKVFICSNTDDTDKNDTKHEEIIDSYFVSQFDFYIKRGLLIAFLHILMIKYTFYDENLILLEKSKDTYNSSYFNEHIPYKHLLINKYKIFRTLKNTLKSLPNFLCIFQNLLEEINIKSLIITDYEELENRIDDIYLFINSLTFFKSIVISNPNKYSQGFLYDPNLIYKKDIEYLSLKYLTVELSNFVFLLEQQKLKGLILYYVDLEDNEDYSMEYNMRLNLEYIHFANVEMNFFRWRDFFKFADFGKIILEFDRLLLQENVLSYIGLLNSYKNVLYLEIKFCNLYILRDFHKILNKFKYLQNLKLNRYIDDKNSSLYMFEAIKNMNYLENLTINLPYRGVYNNSDYFFGMQNFKVLCLTGTNLTQEIPNIKIWGNYTFLRTLIINKAIIKVYDLIEILKIESLTKFSILYCDIEPCFNYISVELSGINIKSLDFTATNLDALKNIDILKEFARLETLHLSNCNLKSGWLTQTNQSCNLSLKILHYAFNCLDRTDLNRMKNLEVLEELNLRDCKFYSCGFFELGNDYKFLGSLKYLDLLHVEIKIEDLIFLKSFKNLKSLNLTLSDPDFFTAKNLLFYLPINALSLKECNKKSIFENSYSRYLYEENINLNLNSLSSKSFILIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU83</accession>
    <name>A0A4Q9LU83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0898p0060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000898">
        <property type="protein sequence ID" value="TBU12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU83"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0898p0060"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15870" checksum="6D091587EBE71B32" modified="2019-07-31" version="1">MPKIPINPPEGFTAIEDMLNKIDDKMKEAINLPIQKKYSHNFHQIFRLNHQRSRYIYNCYYKDKSISKELYLYLLDNLYADRYLISYWKKQGYENLCCVLCIDNSCICRVPLHKIPHTELVECDSCGCRGCSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC5</accession>
    <name>A0A4Q9LUC5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1247p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001247">
        <property type="protein sequence ID" value="TBU11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1247p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020809371" description="Spindle pole body component" evidence="1">
        <location>
            <begin position="20"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="69736" checksum="0CAF533142F786A0" modified="2019-07-31" version="1">MSWISIILTLVFSHFSLNASFYDLDDKEIYLNVLEDTIYSGSSSNNSFNCSNSKKVEPEAILSNDSIGYKNDLTGPRNNSDIEMKTEVDSIDCIQHIELLNSDLLKPLNEYNEYLLVDHELKVKAALDALKTVLCETNNITAFNFRYVFLKKTSNSIKTTNLSLKIRKHLVIINNVYRFFLLENDFLKELEQMYKKNDYQKTLIRCFSNIDPVFEYIINYIDEGIKKLYSNENFEFEYKNLKKSVLEYEFLQCTNVNNLGFHNLYIQNWNLLYSANFIEYWKQTILNILNLKNNYIYLILPEFRSFEIKLKAEINSIQLKNGSFFIAILVLKSILNNPIIKTIQERFRAAVSKNKTFSLNHEECKWYLKNKHILRKHFMKVLKIFVISIEHNMFHSVLYTLERVIYYDFIRKKLSSNFLLCYHFLNIMNNVLFLMDKILVQGLFLYINVFVKSVIEEKCASRYRTCDENIFFYIDISIKRKILLLYIRLYESLFDRQMNFWNKKSGEQYNSIFLYFEDIKKFMETNNMFLILKSRRIGTEFCFNIDDLLLLSSCLIQRIYKLRFEIECFINLRNYFQRFFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH1</accession>
    <name>A0A4Q9LUH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1221p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001221">
        <property type="protein sequence ID" value="TBU11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1221p0010"/>
    <dbReference type="OrthoDB" id="2197364at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="523" mass="63432" checksum="B48F65B49A6AB9ED" modified="2019-07-31" version="1">MRYEYTKADLLINYVKFEDRKHHFEKILGARNYCHTPNDENLMDFYSRYIDVMIWHFRNAYSFTDLYQQIIKIMCTLNIKFNAHFISKYLKFFVLKCCLNCNSSITGYSKVMIFIVKEYPFNFLQNICSEFLCLIMNFIYHEEIIELFKNTFKLKGTNLYRWLIFLKENDFLQSLFERLEKGEEVYNTCRIILSVLNVSCMLLGNKILRIEEWKNVGFLNEISDKSMFLIELFLMQRSYRILNVLYNILALILTYKKNMKICVICMVYQKKLEQKELNFLTNLESSISFFEIMLMIKMLLSKRYTLIRVIYSLKVHVLLVEYFFKHSGHSGYHMCFFNFVRYFFMFPVGLNAKILYDILFQCCFIERIELWTREVLAKEFEKFPAVPPMTSYLIKFYELLFDLKNECEMITKNMPKTDSTKNIEDLYDNNSDTNTDYENERNLDCYVFFDSKLSFLDSEEWISLRELYFDRLNRKLKLSYSDLKEMDCYIEDCIQEPFIRYIFRVLYNDFPSCSLFDENLRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP7</accession>
    <name>A0A4Q9LUP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0779p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0070"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6208" checksum="2EDCEAD143094102" modified="2019-07-31" version="1" fragment="single">MFELFRGRFYRGLSELLESEHVVSRDKIVSFWSTMWNKNDDTVTYDDYLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY3</accession>
    <name>A0A4Q9LUY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0739p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000739">
        <property type="protein sequence ID" value="TBU12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0739p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="279" mass="33252" checksum="7AF26A56F937AE3A" modified="2019-07-31" version="1">MFFDCLVYDNLKVFEKHFFDLFICKTISIPEFSKHEIIIYINFFYQEKVLKIGLTNISLKNGDLYLQIKLDNFSSNKQILNRFSEKILSIPNDYLKFNLIFIDISFFRNSCLISVKENFDVSWSQHNNDLSSVFNIKSLTFNQYLNFLRSLKLEIYRLQSKYLRFKIIIVEENILNQAKLAEILHMVLNKYIKSTVKYSKTSITDDLTISRIKKLLYNTQTDYNIYNEYLNLNDSLKEALSKLFSEFFYNKSIEVVFCDRNNDDSFDTEKIMSLIKNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ3</accession>
    <name>A0A4Q9LUZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1202p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001202">
        <property type="protein sequence ID" value="TBU11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1202p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11197" checksum="0F4B6013BF7956B7" modified="2019-07-31" version="1" fragment="single">MNTQKWSSPFIFNVWSDTTEEWTDQDWRVVGYNSRSRSKSVTYEECKDQDWRVVGYNSRSNSSISRSNSSKDSIINKYTNTYSNTYSNTNNTYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV64</accession>
    <name>A0A4Q9LV64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0709p0050</name>
        <name evidence="1" type="ORF">CWI38_1523p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001523">
        <property type="protein sequence ID" value="TBU10835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000709">
        <property type="protein sequence ID" value="TBU12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0709p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1523p0050"/>
    <dbReference type="OrthoDB" id="2190706at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="24621" checksum="F098E772D4F95BA1" modified="2019-07-31" version="1">MHSIETDEIEFFGFIPSCFIKELKENIIQTLNENNADEETLKLFEKNFYIFENFVLRNVFRFPVSFKFERKITDLRIEENVQKKINEYLMLVKEETNIIREKQIFQNKLDIQKYKYNEYLQINKIEKEMDNLLDSSIKMVNYVQSVSEMRDTFLKSNCGKNNTDLYKMMEHKEIRNNVYKNELKELLEKANIEDFQRFIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA8</accession>
    <name>A0A4Q9LVA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0693p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000693">
        <property type="protein sequence ID" value="TBU12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0693p0010"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020326187" evidence="4">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="424" mass="50878" checksum="1FEC1E143CF92943" modified="2019-07-31" version="1">MKFFRLKIIHFFVHLHIFLCKKPKRDQSYVLKKCEPYLSNDGYYAGEYISSGRSSYVYSFKSNNLKKKVAIKIGRTKKYKNTLSNEMHFLKIIEHENIIKFEEDFVIGKRKCIVMPFYETNLYNYFSKLKSEDIRKKEILVQILKALAYLHSQNIIHNDIKSDNVLIDKDLNIKLSDFGLSCYDGKPCKIFFELKFEENEGKYYHYSPEIRMDEIYGVKTDMWSFGCLFFWIYSGKNLEKSTKPAVYLNYDCYRFFCYFLKKNPELRLSSYAALFSDFFDDLYGFVFCFCKENDFTVENNNCHYKKISTKLSVTCNETNFTIRCKCSEKSKLLFTSKKKEMAKQDSYWFESTRINEFKFGFASEFAVEITSETYLLPELSHSKYRLIRRTFEFLKITLKDQKRNKRRNIKRIIKSRDKFGKNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM9</accession>
    <name>A0A4Q9LVM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0802p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000802">
        <property type="protein sequence ID" value="TBU12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0802p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="80" mass="9387" checksum="7DD4597B41D52EB5" modified="2019-07-31" version="1" fragment="single">MPSPCSLAISEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMLRNGWTELHRYYNEKFGCTETLEVLKKLAQSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS8</accession>
    <name>A0A4Q9LVS8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0780p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000780">
        <property type="protein sequence ID" value="TBU12376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0780p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="53437" checksum="DC9C1DCF93A29A6D" modified="2019-07-31" version="1">MDILPLILVPYKYNYYIKNLDPKNEMKDVILSSPLTLCQGVHELAVVSDGEVVLYTKDDKIGTLTYSDLEYFSFEIKTIKSTVKEMALTFINSYALDLLVFSFKNVYFLLGRYETNIVYFNCCFYLNKTVKYSEIRNIFLCPKNIFLEYQFIETTKEEEMEIFPNGNEFIENPTDLLNKAKNNSEIDENTKDIKIEINTKKTNEEDSDLFDVEMKRIEENESEEYLMKEIEHLKLKRQINNESELKTSHDTKNENLKSEDEKEMKSLVSDRIKKLNAKNTNENVKTKSNESIKSSENINANENIPNDLSNIKNEDNKPKEHLNAKIDEEINVTRNRNVTQETENKPLNVIEHTVKFGKILDKKIYFVKKELQKSFSFDNLPHLKSFIIISILNMSINKYDYFEVRSDTEMFIFKENNSFLLFIYDKVSGEEKNIFEILVNLPTEIEKELKRVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVU9</accession>
    <name>A0A4Q9LVU9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0773p0030</name>
        <name evidence="2" type="ORF">CWI38_0889p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000889">
        <property type="protein sequence ID" value="TBU12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000773">
        <property type="protein sequence ID" value="TBU12396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0773p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0889p0020"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="1">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="37580" checksum="D22CA8AA907A0740" modified="2019-07-31" version="1">MTFQNLKEINNMLNPGYKTHNISVSIQHWQLRDMLKIHENNLIFAQGDKICGYDPDTKESTIFTENLGFYPTSLCCDHGYLAVGGQKSQLCIVELQSKKTFSTNLQGSINNAVQIYNHNGELRLMVCNNDHTIKVINLSNNENICNISHPFPVNNCQISNDGKLLASVGDTNDVYLYAIEDNNYRLIHNFKLINDGGFKVTWNTTSNLFSVATQDGYICVYDVRNLEKIHVIPTKQTPGLKGACRTVMFNRKRSLDILFYTEHMSSFGIIDTRTFSKRQTVLLSQADRDTQISGAVFSECNERIFVAVDDKILEYTINTPSRRVSSDYSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW4</accession>
    <name>A0A4Q9LVW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exocyst complex component protein Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0600p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000600">
        <property type="protein sequence ID" value="TBU12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0600p0020"/>
    <dbReference type="OrthoDB" id="2196302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="2">
        <location>
            <begin position="469"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="77873" checksum="A3C9CD03F205D461" modified="2019-07-31" version="1">MATFSIEDFKKENFNELVLINDKLKIDFDNLDETKKNLTRLITELDDLRQAIFFKKEKMKNELNKKEIKTVKENIELLTKNIENLKLNHVDCFKEIIDTKKHLDELKLMQRIINLVCDIKKREFEKIENAIKNEDFETLRFLCFAFKTLRDISNFDDESLTENISNYNKKIEKMITETFERAIVEKNRTLLRHSYVCFMEMDKSKYIIKNYMQSLDLFKLKVSEYNHEIPKKIDLDFYENENNPFFIFISKIRKYYDDELSDIESIFPNHLEVIEIINKRIFQDLIQTELENFMKFEDSFLFLMNLKSSYIKVKELQKFILSIYEESIGNTLVDDIFEDYVLNAIRKEETAFEEVFQILVNKKKPKNNYILLNESIYNSNYEYKEIFAKLLCIINFFMERAEILNYSEKNIDEIITFFISKLHRLIEIVINTFSGTETLKLCNLLSYLFLVFSNFFSSFPRKSHLSENFKYFVDDKIQEIIDTRFKISERKVKGLIKAQTMKEYYDEAVNTISIKKITCFLKDENIILNETIPGKNTKDFLTLLLDKIYICYYKHILSLKFTPKKAKILVNDIKYLQKFIKDINLIEVFENYEYFTEVCELIAVDKNDIIMFTTGMFHKIPRNELKKILKCREDYHEIKQSVLEADAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW07</accession>
    <name>A0A4Q9LW07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1030p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001030">
        <property type="protein sequence ID" value="TBU11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1030p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="392" mass="44541" checksum="CB9E19E7F3CFB194" modified="2019-07-31" version="1">MHSPTIFRPQIEPVRSHSQQNLYESDTLLQPKTPETSDISHTNTCFANTTGILGDNSFEYLDESDSACVIQENASLTVQNITNALICDQPIIYTAEKQQEKYMHQNRYTSSNHKCMNFNCIETKKNIPRNAELILDESTSIIYAEINPIETCLFKPDINPPKLFQAKETLSTHSFTNASETSIETIETAEQQENTLFKQEIVLKYFYLFNVHSERIKSDSDNNLYEIVSLSPPDQSYTELTNQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQQTPNHTVNSNNESNTQNENSNTQETSVPSLDDHDAFIKWIEEYNFNKSPDPSKITEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW44</accession>
    <name>A0A4Q9LW44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0929p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000929">
        <property type="protein sequence ID" value="TBU12031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW44"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0929p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1004" mass="117796" checksum="312B88A43A00FC3E" modified="2019-07-31" version="1">MNIIKKYSSNRQHIKVSDGICQYCIKSSKTVDHLATRCEKILGHDYTRLHNEVVRCLHLFSNLIGHTVQEILEKEHAEIRVDTRIKTDVKIRNNRSDILIFDKKKNKIAFIELEIIFQDSFKYIRDDIVTKYHKPSLKRLQIPHNVEAYIQSIVLKKTVETISFDRKRVLESGLNAEERWETASMGVIMRAKMHEEPTPPLKEAKREEDGAKNLKPKNNTSLISQGETTLEEPTNNINEESDFEVEENMYKMSILNKQDFAYKNNLIDLRENDLNRNPDVFLRPIYEQNHQLNPGPSTSSDKFLNDYFSQHYQAKPVQSCGNGLFHSHEENPPDYLNSDQELSDDIFETNIRLEPDHNSGNFRSLNQNTSCRNTPLIMTTARDNSFPLQQRHSSVRQNNQEIYDCEDEDDNIKLACADFVLDNTNDTNDQNDPNNLNDLNNPNDLHDLHDLHDLYDLHDLYDLHDLNHLNHLNDLHDLYDLYDLNDLHELNDLHELNDLKDLKKSNNPNNYNNQNDMNDFKNPNDLNNLNELTDPNNLKNLNDLDSLNVMNNLNDTNNLNDLNDLNDLNDATDLINTTYSNTPNTPNTPNKLIDFLNNFEIKNMISDIESVGNESCVDSTQKIFEIDFSENYEERLNDMLAKAKKYAATADNLEHLSRFKKKEILQFIHSRYKNYFQEYSMTRFKNSNITVLKRLKHMQTKYNIILEHLNIFEKMSLNDRKKYISNSISSITEKLHLNMKVKIGGKSILYIKHVIFIIEKNLKNIFMKEEIFNSNSVAPTRKSAYTITNLELMIFDKIMGFKKNDINISYIIDSCNFFVEYERILHEKMKITILYEDLLLLKIKEELSKLKECVKKNIFYEISKFIELYEQNLEFHIKKRHFYSTIFLLSALVIKFDNINKLESTSSSEENINASSSDIIALDVFLIGAIFEKLLRNLNNHDMKANCYGMLNTCRLFLNFINYRNKKRTLLFLQIPCFIAMVIDEAFEFNEIQFKEFLALNHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA2</accession>
    <name>A0A4Q9LWA2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0686p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000686">
        <property type="protein sequence ID" value="TBU12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0686p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="504" mass="57291" checksum="656659899A58E980" modified="2019-07-31" version="1">MRLFSRCGFYIMLNIGFGITARHKENKPVNDTVLRCVDCKARMSENGRVLESSNSETSSYADFVTQKESGTSGKKIARWNFKRLKYLLPWYNRNTSRTRRYIRKNFPVSSENRSISLGLNKIEHNSSISVNSDSDEIKFKVISDSNSNRKRIVKSTPLPKGVEQNSLIFSDSNSNALTSQIDSDQSSCIDRSMVTETEQISIDSRDKTDNERNSFLEPKDIRIRAQAICINKAKRSLFPEEKTKSCNFMRPRALDIDKPGFGEYMRSFYGKEYTNNSDNSSPKKMRFLQKKLSSSSKNASDNISMKHNSGVFTINSNISSNDRFYQTRLPQGTLESNNASDSNSIPKNSSDNDSIASMQSNIFDLNDEISKNIYPKTSSPKTKGSHNNLPSLYFTPVKHADNVYGDESNPLEEAVDYDCTNKKKFSTNPLQPLKTGNNCTKVNGEIIQDCSPDTGNNHFKSAYQCTNPDCQKFILESMKFITKFRGKIQEMRDEIRDSGYKNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB4</accession>
    <name>A0A4Q9LWB4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0554p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000554">
        <property type="protein sequence ID" value="TBU13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0554p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46948" checksum="8B86E86080CD6ABC" modified="2019-07-31" version="1">MLLQLLDCLEKHKDTSTRRAAILKVGNNNKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNGAVFCYIQDRNIFWRADGVCQHCRKSGKTVDHLATRCEKMLGHDYIRRHNEVVRFLLLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRSDIFILDRKKNKITLIEVGITSQDSPKIVETEKLRKYDLLANDLGHIYKFSVAIIPYVMMTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGFESGLNAEESWERASMSVIMRSEVHEEPTPPLKEERREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF1</accession>
    <name>A0A4Q9LWF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0543p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000543">
        <property type="protein sequence ID" value="TBU13058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0543p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="475" mass="56093" checksum="7CA36A3561FC842A" modified="2019-07-31" version="1">MASETNLPLLSNFSISNFAEQPLSRYNTNDTALGSYNHQVVSEAINSCQESPSNNHAGIITPEQDHMQNHSASIHTYMVLNKDKEVVFETKNHAIFKIIGSLCRKDVIRRLEYFYPLIEGEYTISIENILHYRKRINDISDAIKSHVEKLSNIRNYETAFMCKLIKKFRSKALFIFHTKNCPMIYCKPIFLLLPLWIESTIQNELTLAKHLFNVSLILNVTKTLMKYNYECLKPSIDQSLKRNMQLGFLYHFRGNKELFYHHFNLIMEFFGDIFTILGREAYYKIFKLHTDSEFLVNNCDNAFLFTLAHFEITAILFDVFILLSKENFDFLHSIINDYEVLKESQENKDLKFLNYMEKMLDEEGYSTSENIRKVFYDLASIYGKLFQEKGYCDFIQNPFSLNFKLWFRENMAGLRRMLLRNIVPKYFDIRNFLTSCNIFLNYICKVTLNPDITPIGFEDILSEKIFRFLQVKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY1</accession>
    <name>A0A4Q9LWY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0864p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000864">
        <property type="protein sequence ID" value="TBU12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0864p0010"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1156" mass="133186" checksum="96EFE5C970B489A5" modified="2019-07-31" version="1">MIHKYQISILNILSIYFFLSGLFKMVTPPNLFSSGELTQKKYEKTIFIILDALRIDAVLSTTNLSPYHNKLNFLNSIKNKYVAMSISGLPTSTSVRIESIATGIPSNFLKGTNTFIHAQSNHDSLIYQLINSNRTHAFFGDSTWKDIFPNINDVHILPPYNHSPDFTPEKKVIDSFLNSINNFDFIIGHFVFLDHYGHLFGIKGAQIPSSEEYKWFSNSSQQNDTNTNPSQNKDNNESTSNSPDNNYITNILLEYDALIKNVYNKMANDTLLVILSDHGVNEDGSHGSSTPQELASVAIFINKNEEPIDLREVIDNTNEKIFANKSKSNSDNKSENIKSDNIKSNNINSDNKTEDINSDNIKSNNTDNTKNNIFKELIDLRQENLKKLYPFGTEWIGYTGDKLINIIHQSDILPTVCTLSGLPVPYHSYGSLICELVGCKKNVYENIVRQKINVYNSLKGVNDKSKAESIKGVNDKSKVRSIKGVNDNSIEEGVNKLTEKQKGVSNSTNKQHPLNNTPHKQHPFNNSTLYDLDIQGVNILNYILTDILYNYYAGISYIKISISFILITLSIILQLLRGVNNYLNTKGVLLLITIIMVSHSVHSFIHEDIFYGFLFLIFNFCYKNILVFYIYLRIGKYPQHSDDRIWIFRLRKWEKINFESIFYIFLFFIVNEYCKSKESKESKKSKKSKEICQCVTFYKKITNNNITGDSLSNCYNKGCYLHKNGIRNKTLNKVFDIEYVNTHKEYYKGGVSTFNKEYDKGGVSTLKPDTSKQDINTPNLNTRKDYFKTLNDEFDKYNTKTYNLNSCNDSFNTHNLNSCNDSFNTPNLSTGKQLTNTHNLSTSKQLTNTLYYMVCGLKGVLSNIDLILAIIRGVGVKCIEDKTFRISYYITGGVSTLPGMIFKPLDYIFMRYIITNAYISYDPFTFYVLMGMAIYFNGMNYSLTSVNYNVVYLFSDEVEWIFAVIIFIVYFFYSKYLVYKKYLLRYRDRLEGGVNDKSEVVWGVRDKDMLEGVSEESHKQQGVSKEYDKQQGVNNEYNKQQDVNKEYDKQQGVSKITNEQHPFSNSTNKQHPFSTSTNNFFSNTEDIYNASNYKKNNNNLHWLDSYMLISTFSLLVVMIVTYWVYGTMIFYFFFAGRCFIFCFYFLIENVLYSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ5</accession>
    <name>A0A4Q9LWZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0513p0020</name>
        <name evidence="9" type="ORF">CWI38_0478p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000513">
        <property type="protein sequence ID" value="TBU02296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000478">
        <property type="protein sequence ID" value="TBU13289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0513p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0478p0030"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="7"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="394" mass="42286" checksum="8F8158C8BDC9E54B" modified="2019-07-31" version="1">MSNKSGLSVFSGTSVMITTMLGSGVILLPRAFKDLGYIIGSLTFLGIAAITFFTLFTLCSAAFQTEKKGNYSYFGTCQSISPILAYAADSCIALQGYACCLVYLIALKGWLPKVFGLQTDGIIVVGVVIIPLFILSSLKSLKKLWFTSYVSVGSVLFLSFLIIFYCIKLGGYEMKASGFGFGSAISVMVFALGCHQNILKVFNELEKCDLKEIVKVSLFSVIGGSVIYIGIGLTGYYLVGDLKMSILEEMLEGEVSDKINGLTGGGMLVKGAVLGFCFVMMCAFPMQVQPARDSILNLIGKIFKKEKISESARMISTVVFVLSIGGLACIKKLEYGFVLNIVGATCTTFITFLFPSLVYALGKNGNGILRILAGGVSLLSAILSCFMLYQVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX10</accession>
    <name>A0A4Q9LX10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0595p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000595">
        <property type="protein sequence ID" value="TBU12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0595p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6525" checksum="3F1F1B432DBAF612" modified="2019-07-31" version="1">MGVELLEIEINSSHKEITRLIMEINIRLFMSCKKKRSDKKRIGGKTNISDEHEPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX46</accession>
    <name>A0A4Q9LX46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0462p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000462">
        <property type="protein sequence ID" value="TBU13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0462p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="20029" checksum="3FF6452CF5F27B4D" modified="2019-07-31" version="1">MVKEKQRKYGPGLMEPVEVNPNPIIYPQKYRRNGKFNINDYIPAMKVQIIIQNLSRPEVFEGNSKEENGKEEPKEEDIKPEEKEEIKDEIKYENIDEDKVENKDEDEEDEDRSEENDNKKEEDKEENKEILNSDEKTLNPATEDNQIKGMNTKNQDELPAADQSKEVVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX55</accession>
    <name>A0A4Q9LX55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0823p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000823">
        <property type="protein sequence ID" value="TBU12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0823p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1082" mass="126958" checksum="B23C69858E9C6530" modified="2019-07-31" version="1" fragment="single">LYFLEYFRIKQNNKLRNVLKTILYSLAKSDDIKHFKVDKVSFHFSKQEYFSHELFKKISQEYFKILNFKTPSKLSLFIKEKEIYIPNQYKGLYTEDKKYILMINNVFYSFFKEYIAENQKKPNLFILLLNTLDIKYLHVHYVRKTNLKVCCFVLKNLKKPIQEILFYYSPIYDEIIKYLNINSIIRSLRKIVFINSFIETNLRFSYKLNKKIEFILYENSISSERYKVAEIENVENLNIIEEILNNLQYASRKSSIKDFDSSNTNISENKIKFYSKLFEVDTPTNKIKIFELLNLQNKNLEIKCFYDNYGNFLSILITLKELYLKQFAFKNTILEKNIKEIVIQNSNINCNFLTDILSINELESLKISYNNIYIEHDIIIRNRSIKYFGFKANNCDDIPHFYKLLGFLTGLKKYHSSLATDSKCNTYWLIPVFPPPTQQSHIHHQAKHAATFKIPSYDMTNPCILAIHEGIMQMALRTIFDSITADPRNGLEFFLQTKKGLNEWLHRYYDEKFGCTVPLKVLKKLAQSEMGSEVKLEENGERHKFLSKTIESSEKDMHSNELFDSKVLDLINRISHSNASYIIQAAHALCGKITRKEKPRSAWKKNIKSKISKLGLSKDLLEKAQFYLNLSSVTDLSKALVKNNESLNVYEKKITMHESRKQFRKENRRFYRGLYERVKSEYVSTMWNKNNDKVTYDDYSIPFVSNNHPTAFPSLDEFHYSRCGLAYLIPKGILQRGSDYRPITCMSNLYKLTTKCVTKVVHLEVERRGLLAENQLGTVRGVQGAKEQALLNIALNKDLTQKLDYTLRAVLCFYPPRIELGRVLHSFEFKNEKMYLQLLDCLIYISVKYQKYPPCTNKKFLKSKMRRNLEIVQLAKLYNEIEEQNFAQSYIMQKNELVSVSDSSRWLKKKGISGYDMRPCSSISSIEIIYEKRKNINCDKVGITSEIHSKYFNLKDLEKKNLLNTDLALSYRGSVEIISYGITWDGIVTKYDKGIHPVDRIKKSVEIISFDRRKRLELGPKAEESREKASIGVINSAEMHEEPTPLLKQDSNDKDGVKKIKTKDFLFQTEEHNKGTAININE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX80</accession>
    <name>A0A4Q9LX80_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0747p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000747">
        <property type="protein sequence ID" value="TBU12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0747p0010"/>
    <dbReference type="OrthoDB" id="7789470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="106163" checksum="611A6578FB2D4183" modified="2019-07-31" version="1">MSNMGIFMFYIPSSEAKILCPQVFTNKNFFCVDSLAKYIKIAFLLICLIKCYGCIKVEVIFKDESFSDCMSGRLYFELDKPFLITLNEQNKASLEISEQSHSIPPAEEDASNKPSSKETCYQTHVITGQRSEKKINRDAAIHNVLTEFTEEEAIRPDSIKEPLRFSANSQDAIISSEALSEKSLSKQFQNVSMKVPDALASENDISKKFKDQTVLIDIKCHDAIQESIPTVSFEYTNDFIIRSDYFDKHIDSEETEVKVNIEDITKESVDRKQFCLFLRTCRYALDPKRIGLKKTDVLCFVTLLRDLGCYSTSNILNKLYEHLLPLLLSQKYLISSDFADDIGDNAILNFNKLFLPFINTVFDSIDICFDATKEELVFLKVNTPNKSDLLDFSYLKEIKFRIHADVYSVLHHDGSRPKILTIFWLLWLYTIKGIMVSADNTYFTETKDSDNACELLLKKGIHSDIRRQTDGLFNVFATNQIHLDLKSIELDNIVLSEIDVSYLKKFINLESLILVRCVLPLSSTLLGEIPVYFSKCKELRIICFSLSNIFFQSITNSLIEVLDLSCCEYIDFGEDLDLNGSLNNLKSLKLDYSKLNHQIVTFFLKNRCLRSLSIRNVDFEGFINARNFTGFQKSFDFLDISGCQFSKSYLKFFSTNLFVNTFIMQNSKYFDDLKKILSCKSLHMSVETLDLSGNRITSTMLTQIRKFYGMSNLILSDSSIDFFGNPKDVFLFEDSLKKLNISRSRSGNKFLSILSRFNNLEEFIAPECNFDAGFLVYIKSVDVLKKSLRKIDVARSKVEIMDFFVLSEFENLEDLCITLVSNVFVRYFDNNQLPLCENLKSLTFSFTIVDAFILKLIMLHLNLVNLYFYNCEIKTGSFPRDLRRMLIQLHRIGLIDTNISTVDMENLKYFRRNGIAIYFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD8</accession>
    <name>A0A4Q9LXD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative PPPDE domain-containing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0429p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000429">
        <property type="protein sequence ID" value="TBU13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0429p0040"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16985" checksum="22C941A161DFE69A" modified="2019-07-31" version="1">MSKHPVILRVYDLSKGQAKILSLPILGIQIEGIWHTSVEVYQREYYFQDGILHVEPVKALKTYDMGITSLPNDVFHEYLEILSEKYNSTTYDLFKNNCNHFSNDATMFLLSKSIPTEILDLPEIVMKSPMYETLINMLRSDFQSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG2</accession>
    <name>A0A4Q9LXG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Karyopherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0775p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000775">
        <property type="protein sequence ID" value="TBU12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0775p0010"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="837" mass="94588" checksum="8BD472510E1FA50B" modified="2019-07-31" version="1">MNRNEMENLIRGVLSLNTEVRAISERKILEFQESDFYLYLEVLLQIFSDEYLGDDKIGLRTTAGIILRNSIHSADPLLQQKIESRYFSLSENEKINLKTQLIKSLNSSKISVSVCSGKIIAGIARIEVPKTPNSIFFEEIYKMLINSSNTNCTLGLLECIGTLCLFLSECSEFSFKPYAHSILKISIFKLETNEIFEIRTNSLKALGYSLEGISEIIKSENHINTLLLKIAAQCHDNNIKVTACALACMVKLVNLYYENIKFKIPEIILFLNNFLSSKDDEILYQILDFWSSLAEIEENKNEKFLDKYSVQIVPSCIEMLKKVNLDGSMWSVHKSAASCLQLISATISFDLLTVDDIQNCVLRYLSSEEIEEKEVGIVALGSLISPKGDTSKQFLSEVSDTVITYLPIEELTDVSLWCLARICEKNFDCIDPGAGLQNLVDSISNILLQQSKANINAAWVINYFSIYVSERRDKEWDFENVLTFFYDKLLGSLAFAAESVNTKNYTLTTALFTALAELINACAASSYGILDKFLDYLLNRVEKFIERSKNVTEDEFYFLEDFISNYIVLIQQIIIVRGEKSLGEFNNRILSVFIEILSIEKPTCCYGDVYMCLSQISTVVSFYTSNIPKILPFLCRDLTSEEDIILKPVVIYSGDIANITNQGFLVISNKIVPLLLNSLASSKVSSAVKPLILSVFGDVALAMSKSFEMYLDVTMSILEQILPLDRKIGESYVDSLRLSVIQLCTCILISLGDTPKLRSNLDNIIFLTKKVINEDVNRVCTKECVQILGDLVRMYGLKNELSENWVIDFISKSAVTDNKCLKKVCEKVYEIFSNSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH1</accession>
    <name>A0A4Q9LXH1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA topoisomerase</fullName>
            <ecNumber evidence="3 11">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0418p0020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 11"/>
    <dbReference type="EMBL" id="PITK01000418">
        <property type="protein sequence ID" value="TBU13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0418p0020"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="15">
        <location>
            <begin position="166"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="727"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="806"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="846" mass="97771" checksum="E167A0B75315B4CB" modified="2019-07-31" version="1">MKVELQKAPKKSAMSLNALNIAEKPSVAKSISFTFCSSAKNIKSRHPTYVFPYSSYNMTFTSVLGHLFTLDFGNAPWSVDPFILFSAPIIQKPMHPNLLSHIKQQLHSKDLVIIWTDCDREGENIADQIQKFIKEQNQTIPIHRARFSSIDSATLNYAISNLTIINQNESNAVNTRQELDLRIGAAFTRFQTLAINSKSVISYGPCQIPTLGLVVERGNHIKNFVPENQQEILIKIENNSSNKKSEYLFSWKKNNIYDKSFSKLIYKYFLKYPFIIQNTISTPKTRLRPLPTRTVDMIKALTSYLKLPSHKIMEMAESMYTRGYISYPRTETDSFPSNFNYKEILSELECEGEYKNYICKTFCQDNNSKIKYAIGNTAKNYSFKYPRPGKNSDMAHLPIYPLKGSNGLSGSEKAIYDFISRRFLACISENATGTEKIIYGKVDEEIFTCRGLEVLTRGYLDIYKYENWESNIKEEIKEGTQYILFGNESNNHSEVINIIIKNKTSQKKAELILRKSLTKPPDYLTEAELISLMDKNGIGTDATIHEHIKKIITRLYAKKFNNKIIPLDLGNRLIQFYEEMKLSVGKCHLRSEMEKKLVKICKGEIRDSDVLKEEIEKHIKIYKILENGKDKFKSIINNFNSNNKDDGDDNDSGSGYGKEIENKNDFSYFNRNNENTTNNGSKENYNVNFKNRNEKTRLSNFNNENEKNTKKYLNIRDNNDDKNEVLCHCGIICKISKVKKGKNVDKDFFSCEKWPNGCDFFQWCDDKSDETKRKKVQKNSYQQKYSSNSKNTEYTNTHKSKTDVLCHCGYETKSVKAKTKQNSGREFLCCKKLHKPCKFFAWKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY37</accession>
    <name>A0A4Q9LY37_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0346p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000346">
        <property type="protein sequence ID" value="TBU13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0346p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9456" checksum="FD1A481EDD5A8331" modified="2019-07-31" version="1">MRFTYDSFIKEENPDKENLDPKRHVYSPRTLRDLSVPNVIDSSDTSVTVPLNYSYSRRVEQLFDSFQSYKLKHKNIREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX6</accession>
    <name>A0A4Q9LYX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0256p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000256">
        <property type="protein sequence ID" value="TBU18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0256p0020"/>
    <dbReference type="OrthoDB" id="2426083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="51183" checksum="7749BD108B7ACD72" modified="2019-07-31" version="1">MKKILVSVTDDSKEWPPIVLICSWTGTLKRYSAALEVKSEEDREQCGIVTCISDTCTLTNPTEYINPRDKSLILEDTPEKKSMHELDFIVLIPALDCENMLVFGTYEFCVNDVDQKSRYRIVYWLLNLRAAVIYDMTNFINKKPTTLHNYLYNTVKVICLESKSEVDWVCCGFTYFILKGNPQRGFYYRQIYVFPNSKSSRQNGNEFFSTLWQNKFQNFCLEVNLDKSDTIDRYWKVTAILLQNVSVYKFLEIEEDNRGNPTLSSFKEVRFKLISRVERLFSYKFEFKSEHMHIQLLNRLEWVKNGNKTHLAPIKDFLKVNIVSTFKTIQLNMKAKTLLKVYNARKNELVRVSEGTEWPKKESHSFQEIIENEEVVFEPTSDKSGISANALRRGLGLEPTIKINEEFDLEEEKIVVQEQREMHKSVKMVLTRKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ2</accession>
    <name>A0A4Q9LYZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0513p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020639739" evidence="3">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="21400" checksum="54D2BBE3AE5A8B73" modified="2019-07-31" version="1">MTINYILFFFITTIICKEPNNYRNRNIDKDINRNIGRNKRNAPNISEENTIRDYKNDRRNNKDVNRRPTNKHYYEVEPMNKKGKKNETSERDIKNKNKDRDTKDIDRDTRDSRDKQSKDRSGLYIFWILGFVVFFCLITIVIIIKIVVEVNNRNNRINLELLNKYSIPKEDALLLNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD3</accession>
    <name>A0A4Q9LZD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0236p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="550" mass="64106" checksum="8E15DBD541EC0C00" modified="2019-07-31" version="1">MFGTPLLYLPVSSYYGPGYYFFNSQAIPSYTGYIGLIGNNISLPCSSSNYNYNTPVIGDNAPLYSQNEHSCNNQVNTNSSVVVTNSVETSYTEEPFERSAYAYTNNSNSTNFKVPVAIENKDSLCNTTNIVPENTSECKDFTDQYMPKRRYAILNRDNMCFLETYKYETFEILQNIYSGRRISRLENLYPLIRNNLKIYLRGVFGYRKDIADIGNNIKTLAEEFSDKIEFKIEFTHNLLALFKSGIFSIFYAKNLPIIYMKPTFLLLPIWIVETIETDIAQAYKIFYISWFLQLINATMEYNYSTIKPFIHQDIEGNSRDEFSSIFLKNSNNIYDSFSFIAKYVRNIFEILGKQKLYKIFSHIAAVDFIHFHCDAVFSIEYNCSGIPGIIFDVFILLSDESLDLLNTLIDKYFLFKKMPENNGWRFKAYIANQFKFVSYDNNENIQRLYYDVSLIYNKIFSSHVFFHSCLKNIEGIDFEAWISKSTSNLTAKITGKNLPRYNDYVQFLETCNIFLHYISKVVLNPGLVPKKFKDIILAKLFRRVKIIYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG0</accession>
    <name>A0A4Q9LZG0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Importin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0216p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000216">
        <property type="protein sequence ID" value="TBU19281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0216p0050"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="876" mass="102179" checksum="48AC1E87B861AE65" modified="2019-07-31" version="1">MDTSSLRSVFLDTLSPDNTKRTTASDRLLSLQKNHAFILHLPTSFMQDTDQSVKRIAALYFKNSISHEFASFSPEEQDQLLNAVFINISDPSLRSVYISVLQHIIQNCCEPFLQKIATHAATFISSPSTQTVSLYIHLFILKQAKSKFDSSSVTLNTLFDTTGSILISLPNTSDYLITYLTIKLFCQATDYYKMPRFFEEYYLRVYDLCHTLLSSTNGYNDTNTNFLKTRKWCAHFLYKAVSKSQKNFLKKKENNSFIRQNLPTNTFLMVIQKQDLPKTHQFAGDFFVLISRKTELPQKIFLIEKFIFPNLVFKDKEKFEFYPDSYLREKYNYYNNDLRNNVMLLLNEYNKDKETKQQLLQFVEKSLSIPTNSFTTACNKYGAMEFLSCLNDSDFLIKFVIPEINSEFLFLQSQVCYILQFFEAKIVEEKVGTNFVAHLLEKIVAFSGGENEILKVDALLTLPFFFTYSDQTRLKSLISYFVPLLLNTTKTYDLEALNDVMESVIKTYGEEVSSFAPSLISMMVDCMDIKSKNIEKMCGYLRNISGLMDSVRNKEILRNMFERSFLCLINILKENITECYSEVLDVIVSYMFGVKVLDKEMYEILRFILEGGDFSGVVDELSAFFDNFISYGGNNSLPFVNPILNYISVWIKGDEYFFDDDYTAGCKVIESILLNLGSCVKDNIKGILELILEKYESFEREGSSLLYFLLIVMECFILEKEVVIQVLNEKNFLNKFLIDLKENEDRMNRLHDKKVICMFLGEILNMKNNIFRSTDIKELLLRNINEITKTIENKSEIKEYEENEEEEEYEESCSEDCYQDVLEEDYTFESPLDSFDVKEYLRRVLGSVNKECFGWEVMGIMSEEDKRKIYERLWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ9</accession>
    <name>A0A4Q9LZQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0206p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000206">
        <property type="protein sequence ID" value="TBU19518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0206p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="574" mass="68417" checksum="A29B365891565C93" modified="2019-07-31" version="1">MIQAKVTVQKIFNNEIQAIYNDCTLELNKNELVFKFLESGKIIGFIVSFIKIKYCNDVILIQNNKELYKIYFDDSNDYKDFITNSYLNFDLSLDSNENQENLEIKNSSIEKVTDDITKSDYEIGMIDKINDDSMMANLELKDITVDELLNLDIASLDFTTKTQIAKAIFDSKNFEVFLYSRISIIQMLNLSDRRLFYKIFENSKKIIEHFEEYMEKEIDKNSSDFPLIFFEKILQKFMPTSSFLELKNILLKKNLIYDENIKYSLLKDQLDSFQNINDFLDNLYQNCKLDETILNIIFENILSNNNEFFIVLNKVIDISYESTLVFFLIESNMEFLCKKIKSSLMNKDDYYSIEWIIVCLENLLHEKCNTLLLDIFYSKFIIILFSDDFLIYVKSEDSHILFKLFTSLLSIHSFRFRDFIIYNDFLRFIFTEYQSRIYSKHHDTIFSIKNQATECFNSENNFNFVKSVNGINITTLYSEDFNKEIFSRTNLLNYEIFCIKIFEIASQNNTILSSYFFKNNLFIRILEIFSRNYTKRNSLYSYISDIFINSDKKFLEKLTNLYYNEVNRILNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU4</accession>
    <name>A0A4Q9LZU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0479p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000479">
        <property type="protein sequence ID" value="TBU13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0479p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="241" mass="28295" checksum="7861E1C6B995C318" modified="2019-07-31" version="1">MNKLGDFYIFFIYINTFSVYINYTRRHNEVVRCLHLLLLNRYKNSDNEYAEIRVVIRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIEKYDLLANELGLIYRCCVEIIPYVMTWDEIPMNVEAYIQSIVLKKTVETISLDRRRRLESGLNAEESWERASMGVIRRSEMYEEPTLPLKEAKREEDSARNLKPKNNTPLISQGGTTLEEPTNKINEESDLEEETALVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV1</accession>
    <name>A0A4Q9LZV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0287p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000287">
        <property type="protein sequence ID" value="TBU17349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0287p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="756" mass="91584" checksum="D6108380B39FC5F7" modified="2019-07-31" version="1">MFIYYSIERDIIFNVVNENEESYIGSIIKKIKLECLCQIKRDETNETDEKNCLERMLVRDSNRHYEQYCIEYIERISLKFDIFEKFNNMNNCIEIFLCHHIKKSDFLIFYEFIISYYLPVHKMTIKKFYTILYFLEYFRVKYDNKLRNAVQNIWCSFMESNEMNNFEIKNLSFHFSKQNYFSHDLYKKISQGYFELVIIERNSNFSFFIKESEYYVSNIYNGIFREDRKHTLVINYNFDTFFYKNVVVNHKSQCLFLMFLNTLDIKYLHIKYLNRANSKSFCFILENLKKIVDETVFFGCYISDEVIRSLNANLSLVNLKKIVFIKSKFDTSLIFTEHLSNIEEFIFYEEHYYKRYTVPEIKEGDLNIAKFIIQSLKHIHPQHSIEEFIKENENISKQNKDFYLKLLNEDKFRDKVKITENFKCKNKNLEVKCFYKYKGCFKNISITLKNFNEKQFFTTENTILEENIKSIKISYSEIKFDFLRDIFNIKRLERLKIEFSNIYIENEIFINESIKYFRFSHNNSGSFCSFFKLIDMMIGLQEIYFDKTNTIKLNRSVDQIVYITELDLWDINKMIDFLKLSEKNEKFNFKATNKDILDSEYPIDFLKFLFQNYDISSMKQLSIFDFSINNLNVKSLSNLLSLEKLNIVRINFQNISFSELFCASREYKIKRMGLNGINISEKDLIFIGNLKKIADIRLWSCVIQGNTYNEIKMLFLNENYIELKYNTREDGLTEETIKFIKEKFKTKYIVIRELWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M015</accession>
    <name>A0A4Q9M015_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0403p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000403">
        <property type="protein sequence ID" value="TBU13531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M015"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M015"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0403p0030"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16133" checksum="AF0097FB3E271F74" modified="2019-07-31" version="1">MPIHLNFSKNIRSSNSAFAFVSIGANIKIPQGSGPFCYRIHGQMYHISGTLHPDKNHSRQYAQLYIFDEDVANNERINEPANKTCYLRLMEKISDVMKSNPFACAFKMMYGVEEAQKYLKPNIETQIVMEIVQNRKTDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M021</accession>
    <name>A0A4Q9M021_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0438p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000438">
        <property type="protein sequence ID" value="TBU13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M021"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0438p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="209" mass="24866" checksum="622D05A9DFA3F75A" modified="2019-07-31" version="1">MIFTNRYKDLLEDTPLAIPFLKIFFDTNLGNIKTVFNVCSERTIESYKSRVYGSYLRDEMNKLFKDQLKKVNFSDSLYLTELDDIIPEVENIKTRDGKKQIEIIIGSINNRKFIKFLWSKVFVLLRVGFLFLLKEPLSFLVYDFERNLCILNAEIRTNDFYKNIESLYTGYKWVLPEYYDVKYSSTDQKLKGPFFRTNLDKKKTFSCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M035</accession>
    <name>A0A4Q9M035_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0168p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000168">
        <property type="protein sequence ID" value="TBU19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M035"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0168p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="67896" checksum="FC725844348677C2" modified="2019-07-31" version="1">MEFIYFDEKITKSYIVITDCNEVSFKKDSCSLYENCMKKIQKNKIYLRLNDHNVKKLSKFMVSYNLKNTWIFLFKIIRIDLVYFVFDLEESFEIIFKLLFGVKFYTEKFYFHSFKNATIILLKMRYHLFSKNLNVLKFNFNFNLNELKQILSLYDNVNKITIKTHEIDFGTLKFLISYCRDNSYKSIKLVSFFYISENTISNILKFFPKNLIFLSDLIKKENILKPFSSHYMPFIYNAFYYITQNKLNFLYNILFLEILNAREIQIHLNNNYIPIILDDSIFNSLRYCKTLKKFCIKNIKLSNELLMYILESTTLLFVEIIDFEYAFNDEFFTKSSVLNFNLKFFGFTNSKSFIKSKFMIYLAKFRSVSNLKIYNTGMMLENLYPRFSKHNFKFVKKNISKKIFLKKLEIIAWTSLLYMKNCLFFLSEAYDLVELESISLNPCELTEIDYVLFCKMIKLKVVKIESFGKINNIDLKKLFSNSALFNTVIVMNISVREITSDDIRILSSFKNLMSLSISSEKIDFMTIKNIKRKYFLTTEFILKEPNRENRSNEINEHLDSEFMFSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M099</accession>
    <name>A0A4Q9M099_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0144p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M099"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M099"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0080"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="520" mass="60674" checksum="6D8D0C975CDFA81D" modified="2019-07-31" version="1">MDIKTLTKQKIITEVIKHGHSKDEWRVMIIDEYTASIITNVFTISEILSYNIISLIRIEEKEKPNLKEFSVIYFVKITETSIKSIKKDFKKKSFKSFYVITANEITSNQLNKIDLVGPPEISIKQLNFGFVPYESRVFIVKDNLFDGIKSFSNIFDINFNVCYTNDLTKDIAFTLNDYFEIQKKKNYGNLIILDRSVDLYTPLLHYYTFQAILHDFKFLVDNFYIEKEIHFEESDKLWTSIRHGHIAEINNILSEKAKILVSGIKKLEKDIDIKDLAKIVAETPENLKLKSEVEMFLELLDKSITKFELDNLPLVSDLEQSISTRYTKSGNKYREAINDFFDILKNPEIRKHDKLRLYLLLLVSKYTLEKNEEQHIIDKGWLSKSEINLKNKIKKMTEYFIIRKELNREIKYDISRYQPILKDILYSFHEKKKCFINIIGCKEDSATEEVSLRQGGFVFKSNNGDSTKKKKVIVVYFIGGVTFAEIAIAYDVSSKLGIEIIVGSDQILTPESFLDNINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B3</accession>
    <name>A0A4Q9M0B3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0423p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000423">
        <property type="protein sequence ID" value="TBU13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0423p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="30880" checksum="AD87461A3274F61B" modified="2019-07-31" version="1">MIRDSSDKACELNYTEHLFSRNKEIEISRFELFYSFIIFFYITHEKITIDGFYTILYLLKYFKVQCDNKLRDVLKNIFVSLSRSNDITNHDVTKILFDFSKKEIFSHEFFKKIAEEFFNLFIPDIDYVSSLYLKEQDVLLQEKYYPLYTDNRRYIMRLNRNFFLLVAQIINANIKPIDEIIFYKIPIQDQLIISLNINSNFASMKRIIFLESMKETNMKFSYNLLAVNEIIFYDQFYIYQEDKIVESLILKELTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B9</accession>
    <name>A0A4Q9M0B9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0408p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000408">
        <property type="protein sequence ID" value="TBU13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0408p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38205" checksum="A02F6F89C9564C55" modified="2019-07-31" version="1" fragment="single">LEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKNGSVRPRDEADRNVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHKEVSHSVQEILDNEYAEIRVDIRIKTDVKIRCNRPVIFLLDMRQNRITLIEVGITSQDSLKIVETEKLRKYDLLANELGFVYKCSVEIIPYVMTWYGIVTKYYKTYVKRLQIPMNVEAYIQFIVLKKTVETISFDRRRGLESGPNAEESWGRASLSVVFELRCKTTNTFFKARDNEEDDVKTENTKNLLPLILDGITTAKEPSTNTNEELEEEEEIEVGEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C6</accession>
    <name>A0A4Q9M0C6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit beta of translation initiation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0149p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000149">
        <property type="protein sequence ID" value="TBU20015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0C6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0149p0010"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="6">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="34398" checksum="CE95497A89EC251B" modified="2019-07-31" version="1">MKRVDIDRNNKDPFYRYKMPGVMVKIEGKGNGIKTVIVNLEEIAHSLRRKAVHILKFISYELGSISFFDSKNGRYIVNGSHDTNKVQAKIYDFIEIYVMCEVCRNPETFFVYEKTLKKECLACGNSCKVDGHTKVDNIVAKDLENDSSFSERDKSYYDLTVNIGDQNMELKNDLKSLLDANCSAEDIYKCFMDNKESIDIFYQKVFQIIENNPRKILACSILINERKDGCVEIFKALEIYSSEKKSYDFIFISLQAILDNKIVKRSECFKYFQTKSKYVSEEDSMNIRKALSPLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R8</accession>
    <name>A0A4Q9M0R8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0364p0030</name>
        <name evidence="2" type="ORF">CWI38_0364p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000364">
        <property type="protein sequence ID" value="TBU03059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000364">
        <property type="protein sequence ID" value="TBU13680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0364p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0364p0030"/>
    <dbReference type="OrthoDB" id="2190341at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="93" mass="11245" checksum="78C9B15A0A2D414D" modified="2019-07-31" version="1">MEEKIEDIIVRSKQKDVMLNKLTFYMKENGFYDVVCKHLEELASKDVNNGDEYNETYLKLFEFISENMPTEIYQKFYIDVKNFLDDYVHPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V3</accession>
    <name>A0A4Q9M0V3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0200p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000200">
        <property type="protein sequence ID" value="TBU19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0200p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="37780" checksum="F99FDF7A07C2007B" modified="2019-07-31" version="1">MEYFLKNLALCVSNPLLINFKSKSNIVYVFGKTNFCLNKCVRPNNKVYKDKTFLPKVQNYKTRKNNRKNSNLQIEKSTPYPHRSRNLYENTKNNSPRQVKTRNQPAYTTNYRQDKDRIIKCVNCHSYNSLPPRPLANIPYDIITMSTIADSEILERLYNNNNTIASDNRTINTTETSYRKKRGRNKIHDRGKPVSENTLLSMKQIELIVNVNMDFINNDTVEIISNENDEEALSYAFAKLPACKLSQSPEIDEKGTLWAQGLIERMRKIKDRQTNTNTRLRRLAIKIIQSSGKELQDVVRSLNILAKDVKEEFTPGYQQKPSYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W0</accession>
    <name>A0A4Q9M0W0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar ATP synthase subunit E-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0370p0040</name>
        <name evidence="4" type="ORF">CWI38_0458p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000458">
        <property type="protein sequence ID" value="TBU13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000370">
        <property type="protein sequence ID" value="TBU13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0W0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0370p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0458p0040"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="194" mass="22898" checksum="7E5A3478523729E7" modified="2019-07-31" version="1">MEVSQEQDIERIVSFIKHEAKEKVQEILIKASEEYNTEKAKIVRSETMKIEKDYLQRKKKLEIQKVMNESVVRSELRMKELLKKVNLLEIFFMSVKKSLKNRILKAENILKDCEKIKENKILIFCLKKDEKYVKNCVGNKYEIEVKELGEEYIGGVIVCNSDRSVIIDNSFKSLIEILKEKYMSLIWKILVKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C1</accession>
    <name>A0A4Q9M1C1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0176p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000176">
        <property type="protein sequence ID" value="TBU19907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0176p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="867" mass="102633" checksum="060040659342D359" modified="2019-07-31" version="1">MKLQTKNINFPILTKIEELLQINQLPLNDDNIINACIQILDETLIQKQDLYYLELLKIIYSKKKQISSEIFLNKLDKTLLKILESIVSKENLNVSYLRIIFKILIFLSAKNILKENLFFYFKIASSDALIKKKTIKIFKKYLVKKDDKIYDFIIETYKNGSENEKISIGEILCIFNEYFFKHFYSKNLLDILVDKNLKIKLERILKIMAKCCSKMTENDLNIYLETVYFAFDKIESNYEIIAILKEIFYKNHIFRIKKNVNIIEFDVNIFSIIENLLLKCSSRKEVNFLSELLEYLRYFYEPYFISTFIRLSSKFEDKPDLQTCILLRKFIKYIDFMKYYNIVNINTWIPVFRNISNKDISIFLEIYSKYSIESVFAIFPFFCNYCSDKKNILSKLISIIIENKIMNNYILKGITNIIISHKNNLLNDLRLENNISKNESKHILEILNESKIFDFIFTFYKEKLENNLSLITSDMKECIKCLLNLKNIDFSKGLIEYINEYKQIENKFEDRQGFKKGPIENIDNSNQMKNNIKNSFLNVSDQGNSIIFFYNDICPQKIEFAFFSNEKIIPEIVLKNKILEISCLFTAVNLLSLFLEKIQCSHEFIGKILELCVENKNQKVKKICSNLLLQLINIKKIDLCICNYIQTNFENGKYKFLILSSLYFIGCNNCSLQNKENLLQIIYNEMNTNNKLKILNNLKQEWKIQLLENSIQQPDTLKLSVIHNLLQNIILTDQLRNKILNFILEKNQSSISKITVEILVHLTNFNLEKESLNKIMNYISINLQILISSNLKGMKVLVKNLSNNKVSLPSRIKNILSIFKKNKNTKRTASINKNNFIEIKEDLNRKNYNKNKFKLFENNKRFRKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J0</accession>
    <name>A0A4Q9M1J0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0254p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000254">
        <property type="protein sequence ID" value="TBU18110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0254p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020751393" description="Lipoprotein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29296" checksum="975E4A11573D49BE" modified="2019-07-31" version="1">MYFRRLFSKYGFVSMVFLFLTCKSSEILNDEPRTRSGKHNFKKSRTEIIFFVKDTDVHVPKVTTQEETIPSIRISNFRVRTDLFNSMEEKTGSKEIKPNSNCSDVTIQEETISSIQIPKFRVRTDLFNLMEEKTGSKEIKPNSNCSDVTIQEETISSIQIPKFRVRTDLFNPMEEKTVTEEIKPMSNCSDVTIEEEAVSSIQIPKFRVRTDLFNPMNEESDPKKTKTEMGARHRPIHDRLYSYANSYESSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S3</accession>
    <name>A0A4Q9M1S3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20623" checksum="4EE21AC67F318351" modified="2019-07-31" version="1">MSNSNVNIEKSSKEKLSSTVSIIIFKMELKSILNHLSKTYFIYMKNIIRIRNNEISGLDAVTSDYVVCILLRTAKYKLDILNNFLRPNYAINYAINYAYKRKLNSNTEILFVNAEDIPSAFLNRELVLFEMIVEFRRKVTDESKYKLINILNEIIETWYQTIIYDLRTLNKLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S5</accession>
    <name>A0A4Q9M1S5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0035p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="23882" checksum="2A35A767BD258EE7" modified="2019-07-31" version="1">MNVGAYIQSIVLKKTVETISFDRRRGLEASMGVIMRAEMHEEPTPPLKEEKREEDGAKNFKPKNKAPFISQRGTTLEEPTNNINKESDLEEEPKVVKEIIAGFDGNKTTLYLQLFYGCCYEEERLIIIFELWSMRSVSKKIKYIRLGSKEFLLLHRIELDSGLTCVIFCSEHVLLQLLNSHEKSKDTSTRREAILRYLITNFTLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V9</accession>
    <name>A0A4Q9M1V9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0205p0030</name>
        <name evidence="5" type="ORF">CWI38_0226p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000205">
        <property type="protein sequence ID" value="TBU03959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000226">
        <property type="protein sequence ID" value="TBU18872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0205p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0226p0020"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU18872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="448" mass="51455" checksum="74FBF117E16BC910" modified="2019-07-31" version="1">MRQKHPLNIKMPETTEDSVLINKKFAKKMRINICKEVPNEVLSSILMHMGFTQIKKMLLVSKEYLNKIRNCYFLWKNKCEPYGLPFLRSNTEFLSIIRKNKYLKQSWKKGTDERRCCVVTNQTDITQMVSTDKYVISSSDDQTIKIFSYNGIYIRTLIGHLGGVWCFCSDGKYLISGSTDKSIRIWDISTGWTIKVLTGHRSTVRCLKIYEKLIISGSRDSDIRVWNYEGDCLHILSGHSASVRCMDINDKFLLSGSYDGDVILWDYKNGKTIKKMARHSNRVYSVVLGKNYIASGSQDATINLSKIDGVLIAVLRSHRLVVAWLFLVYGIKEELKYEKYIITSGADGYVCKWDIMTGNLIYKISENEQITSMFVICDLLIVSTVYNVKMYDLKSGKFIRFLKKNVSGVYKVIGNDRNIIIGFSEDVTPNIEIISNIVHLNKKIKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W1</accession>
    <name>A0A4Q9M1W1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0030p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0080"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="16172" checksum="06BC7DE3A5F42416" modified="2019-07-31" version="1">MEVFKSKLLDSQVDLNKYYRMFHSYLKSEETLMCGITPIEVGITSQDSLQIEYDLLENDTGLIYKYGIVTKYHKTYLKKLQIPKNVEAYIQSIVLRKTKDGVKTKITRNIILLILDDIITAEEPTISMNKDSDLNNIMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M222</accession>
    <name>A0A4Q9M222_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0022p0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M222"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0140"/>
    <dbReference type="OrthoDB" id="2191799at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18624" checksum="2A5A921E9CE35352" modified="2019-07-31" version="1" fragment="single">MYTDYQLSSRKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M266</accession>
    <name>A0A4Q9M266_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0101p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000101">
        <property type="protein sequence ID" value="TBU20257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M266"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0101p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="50606" checksum="4342CC1149A8DE7B" modified="2019-07-31" version="1">MLYTECIALFTDEMYDVCLYLDIFNEKTLLRIKDMLLQIQSGLEDLYFINQIKNLKKWDSKKLSVEENQPEIFKVFDEFLSNEIILQYFFSQFCLFWDCFFVPKEKFSDIMNDSYIFKSKRIQNYYEQGISYDDYFENIKKIYKNVGLTSNNKDLLFSHGLSAFRKLIYRDFIFPFDYERTSFQICLLEQTNILEFNHELLDFIFPNSNIFGKNPDSNIIGRLNNCKSINFSIMIESEYLIAVFIKDFIKKIGEKKFLQMLCMVNFENKKTNFYQSLESLNVLEPVRPLDEAVFCYIQDRNVYCGRRYVATCNQSKKIVNLLAMRCEKMLDHGYKRRNNKVLRFQKILDNESDIFIFGNFCNTINLIERSVRSIIHHKMSCLIYKCSVEIIFYVVTWDGIVSLSVILEAEMHKQPTPSFKQVDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3B4</accession>
    <name>A0A4Q9M3B4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0788p0010</name>
        <name evidence="13" type="ORF">CWI38_0115p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000788">
        <property type="protein sequence ID" value="TBU01166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000115">
        <property type="protein sequence ID" value="TBU20192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3B4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0788p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0115p0010"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU01166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="395" mass="44215" checksum="A78660663FD26C82" modified="2019-07-31" version="1">MTEIPTASINNAYTFLSSNLDIQISEEQKKIKILKEIRDKLNNQVKTLKEERDSIQEANSVVGVVVKKMGKPRVLVKIQPEGKIVVDVEDQIDYDALVSGTRVAMRSDSYMIHKILPPVVDPLIALMMVEKVPDSRYDMIGGLDEQINEIKEVIELPIKHPDLFENLGIPQPKGVLLYGPPGTGKTLLARAVAHHTECKFIRVSGSELVQKYIGEGSRLVRELFVLAREHAPSIIFMDEIDSIGSVRIDSAKSGDNEVQRTMLELLNQLDGFESKQNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPKGNARLEIIKIHSRKMNLTKGICLETIASKLVGCSGAELKAACNEAGMFAMRERRVHVTNEDFEMAIAKIMKKTTVFDTEARKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3C2</accession>
    <name>A0A4Q9M3C2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">14-3-3-like signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0306p0030</name>
        <name evidence="6" type="ORF">CWI38_0114p0060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000306">
        <property type="protein sequence ID" value="TBU03370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000114">
        <property type="protein sequence ID" value="TBU20202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3C2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3C2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0306p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0114p0060"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="267" mass="30970" checksum="6F94D023CD4A0525" modified="2019-07-31" version="1">MKNIDFDRLISRASLSERAERYEDMVSDMKQAIKIAFEDKVELDVKARNLFSVAYKNLAGARRASWRILSSERQKLECKDPVQHEIAEKYVVQVEKELHEICDDVLNVIDSSILYPESLNTNVESKVFFLKMKADYYRYKAEVSEGDVLRKCTDESFHAYDSATKEASVLPPTHPVRLGLALNFSVFYYEIHKEHEKACALAKQAFDDAIAELDQLSEDHYKDSTLIMQLLRDNLTLWTNQDDNTQMDEQAEQEGFEKEEENEATPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M579</accession>
    <name>A0A4Q9M579_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0029p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000029">
        <property type="protein sequence ID" value="TBU20726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M579"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0029p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="802" mass="95619" checksum="755C17EE5266A8B3" modified="2019-07-31" version="1">MNADGILKNKEKSKFLVIRHLKDVSKSIYHSYEYHYSPMLNNRIFIAFLFLTNYTFCLNVRFLNMNENDVSAYQDIIYSYFMSLETSSIVKIENPVDGFRSPLAAKKADEDLMIVYPNDISISFEFLDELNSENSDEIIIYMTKDNLSKFTFFIKILQNNDNVISNISTQAFFETLKYLNILRVIRNKNYKIFIRSLVHYSFISSVDFVSRASDSFLNAEDYNNLQVRDVIKIFMRFYFMKNAYIYKMFHKNRLLRFSSTLHKHRKQESFKKITCMFFFQTCYLHKYLSKTKAINIWKILMNIFSVDKLCINLFPNNNVLDLDLMISLLPKKVIKFTVHIPKKLLPIFNKLYQIGFFNSVKNIEITYHDEYKSFLEILQYFKNLEKLTLELLWVNYEGLVDLMRFEGLESIKVMKILINKEIYFPRNITANSTLKTNANIIVDISDRLEISDIENGFKIFSSYRFHDFICGIDLILCKESYNSAYFFQIFNFELIKRLKVDLKNVRNNRLESYEFLESFKSLTKLYLKNIELSHSLFKAILRSNRLLSIVYDDFKTTGFNEIDTEMDMYNESVIRMSFYSIQGNLNNNLFVFLSKFKALTHLFFDLHCLLYDYRFFDEYQDEVRDLDISLMGHWATYPKLKSLKYINKFGAKNITSYSVLRLFSYFFNLEDLLELYYNVSSLYKGDILVFSKFKALKYLNLSIKETDKYFEILLQILNQNIKNTILKLEILTGKYKYYEILLISKFKKLKILKIGFQQKDEIDIESLECLICLNLIEITIYVIRGTSNYYSRLYINTIFTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5J1</accession>
    <name>A0A4Q9M5J1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0016p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000016">
        <property type="protein sequence ID" value="TBU20851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0016p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="111" mass="13105" checksum="872CB853C6E53B8F" modified="2019-07-31" version="1">MGLLNSRQIQDIFEKALSMNEDKEMSVKTSRKKLLEINVNFMVGIISYELYREEVWERMWIGGKENTFSKGYINVCSMRGGIILCGREKFNIRRKVGIKLDLYLRKVYIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX54</accession>
    <name>A0A4V2JX54_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1744p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001744">
        <property type="protein sequence ID" value="TBU10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX54"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1744p0020"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="194" mass="22572" checksum="13D083C9C6D0595C" modified="2019-07-31" version="1">MENYDFGPNGGLIVALEELYDNIDELDLESLSSDFLIVDCPGQIELFTHSDTFKNIVEHFKKYFTCCIVYLIEAQFVSDPTKFISGCFVALLSMCRFSLPHLNIISKLDQLEISREILEEFCQLSESIKDHIQKKKGEYNQLCLKMYDFIVENNLVSFLELNYDDENTFDTILYSIDEAVQYFDDAEPKDHSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB7</accession>
    <name>A0A4V2JXB7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1385p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001385">
        <property type="protein sequence ID" value="TBU11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1385p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020674796" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1542" mass="179736" checksum="82D467A9274C9A52" modified="2019-07-31" version="1">MKRKLIFYVFCIPLRFMGLCMNKPEKIYFPLEIYNDEDYMDRFNSFNTSISLNCNLQTEGVFKMLDFVDKKHEFMYFSIIRCVFIRNRIDCNSKNVFLLSLILRIYYLQNFIDIDGNLREDLEFYDTQGNLILDFEKFLEIEVCFLEYKFFLENYNFEINIVEDLYFVNINSKKAVLWLFLKSNQLILKNEVVSGILKKNLFDAIHDSIFYLLIAIEGNERINMFKKQNFDQIFSEYKIDSIVKNKINGNNIFELLRNWLYDEQRGMSCGIFGTSISVSSVFFTFFGADILLPNEERLTFGILNEAYNIQESYNVDFLDTLKILLIKIYDEILKIEILHSTAKTFVYEATEFNNNEAAVENRDLKRIENSEFLGFERIFLKANIILSDLIKKQEFMVLINQIDTLPKEIINSYMILKSFLCNSYQIYENCRKELQYSHSLKYLDVLLEYGKIMMETKNHDLVFRTHNRFLTCIKLLKNLYNLNGSMDCINNEQISLLIFFFQVVNINDIQSIHEIKNLFLEISRQKFLKKDSDVNYAMKLRYYEFIEKVLWKFLELQEIYTLQSIPSTSFGHNYVENNFSDLTESSSDTTIQSLLSNRKCSTPLQNIDKDYESEFSGCTNLNQTMGNVKKNEDIQHRAYYNESGYVSNSGSCSEGHKNDSFLNISEYSGFAPHFNPLFDNILSNNSDIESRTKLKEPVEKNRKTEEKSSTEYCVIRNSNSESDSLSNIVYNSKIILIKNKFSDRLEEERKILFSLEFKSVPTTLLLRNNPVSDINRNTVGEENNNLMHSEATIEEENMDILKISLKCKEYKVYETKYLFEYEISVSTKKNSDKDFNDDSNEDKEDDTSTIRSNNQDSAATNFVDENNYKIKIMAELNIIEKGIDEYVKESTFLKIYNFMRYMRNIFSNVECFSEDSVWFIRATSQFNIQNIILDINNELEILDISEKNILFVKNCKEFLLKKICLKYKFDYARVDRTNMDFFNSTNEGENFVLSNSEIAAMLIVLSGASNETSNDILIPIFFRLIQNSDSQTRLEQHVPLNKSNPIDSKSSLDFDPFGSSISYSYEPEQTSVDIVCDKYDTGIIINSRSSSDPGLDSTSDYNTEEPFPNNSKDSFCQDYSNLTEERNFERLLTLSRSSNSMEFHSLNESNNESRCGGNDQVKTLSNFSRVDSTSDIREIDDVFIIQGNSKSFDSTNDNTIHMNNSTEMTDYNSLNNPEEIFVTPRSFNADQTISSEINNDAFYPRTSTPISTENNISLQKEFHSKRKNLPSIFENPNEFTFKTPLPYNYGFFKVKTSESKENPASTSLEPKQKISKRPKLKPKKKLHRNTTYTVFKKNDTPIHSPTPADSNITGNTQVKSNDSLPSTSTNNLSISILSADSLPLLNSKNKFLRKNTQKSNVSKNGSDIMPQKRQLLNKIRKEKQIKRMKVMKRMKIRNTVNKKLSTNKAVNPNTLLSSNSSTSSAATTSKKSKTSEKISDLKFYFDSKNIEKYKKIEKYKKNQHERNKLRAQKKAFKIYLIFIVSTLFFTSFWISIYIFFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG4</accession>
    <name>A0A4V2JXG4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1075p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001075">
        <property type="protein sequence ID" value="TBU11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1075p0020"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020602105" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57996" checksum="45214E1ADEACBF02" modified="2019-07-31" version="1">MFSFYFLNILNIFLELFKIEDSRGIQTRNSFEEVQSKLLSGVERLFHTRLNAKKLFSAINQHAISLINYQIGVLRLEPADFSKLDKAVRTVLVKNKIHLRPGCKKRLYLSRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEKVIKKSLKEAQLAKLYNEIEKRKLNSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSNAVQEILDNEYAEIRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLFYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEILMNVEAQIQSIVPKKTVETISFVRRRGLESGLNAEESWERASMGVIMRSEMHEEPTPSLKGEKREEDDAKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEIEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ5</accession>
    <name>A0A4V2JXJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0918p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000918">
        <property type="protein sequence ID" value="TBU12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0918p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="367" mass="43582" checksum="ACE199A1AFE47A9C" modified="2019-07-31" version="1">MEDQDCKICTRNEFVLGPQTPNNLDLLCNKCREHNKKLFKRENFIKRYFYLYKVTLGISIMNTIEAWITHIIFLLMLYSCIVQGYRFIQSILYGAIDHYKANIAYSTLGFPEKSKEILTRRAAILKVEKEFSRCSTCKIIRRKLHSKLYNIRKIWLVFSHSTRWVKKKSVRPLMKQMYSEEERVFTNTKILGHGYTRRRKEVIRNYRPDIFILDKRKNILILIEVGITFQNSLQIYDLLTNELGLIYMCSVYLIPVCDNLGGYYSKSLIMQNIHSFIVLKQTVETIYRNPRRTILSLKQATNDEDGNTMLNINERLDLEEETIVVQKVEANAVNWKNGFNREIMEKNKRKVKSIRTIKVSRRDEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY22</accession>
    <name>A0A4V2JY22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0267p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000267">
        <property type="protein sequence ID" value="TBU17868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0267p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="32603" checksum="DAF167C4BED1F390" modified="2019-07-31" version="1">MIVNQETNHSSQLNSSFTKVICLGGTLKLFEEVKSKHISRIYTAGLVNNKVHICSECNGSVFFTRTKHGGDLRGVELQSKHMVLQLLNFLRKGKKYRLGETQLKKSLEKRQLVKSYNELESLKLLCKLYNARKNGLLWNIRPLDEAVNVFQGEDGVSQHCGRSGKIIDYQATRWTKSLGHALPDGKMNQSLKRIWGPSVEKFLDNEDSHIISIVLNKTVEKNSIDRRRGRIFMETNIILKQASRNKEDLKHLKTKSITLLISEGETRLAETTINIREESVGAKEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY29</accession>
    <name>A0A4V2JY29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0251p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000251">
        <property type="protein sequence ID" value="TBU18155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0251p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="795" mass="94267" checksum="5B6B3FBACBB4E9C2" modified="2019-07-31" version="1">MIINFDFKNIEKSFLKNIDNWISILVIYLLLSVNSTTVSFFVINEENCISNLLVSDLTLEMIFFSNKSVEWITNEGKITIFKNNIVRYESTNTETKYYNPSILAIPYKNNMLLNSKYIKNKFELEKANIRIFFKDVSYSSLLLFLKLVNEPDYIVNQIKIEAFMDILIILSILDIDSSKERNIFLKYVFLNVIYGMQNINSISTIEQYCANFQGNIVKKSVCIDLFVFLIGIITFNDKTAQQFIVFSEKTNLAFKYVDLYSDTYSIIKKNENDKLFLRLDDFSIDKLCKIARIDYLLKSYGLLFKITKLDLLYIIFQKEDTYTKAFALLSDINFKTEKLYVHSIRNTMKLFFWKNFNQLTNELKVLKLRSSFKAEELIKMLDQCVKIKKITLYTNIMNVEILSIMINFSSKNPSVSFKVFCLIFGFLDMNFSIFESITDKICVYIHIIKLGSEIIKIPTELLPFLHKYKLEYEYSENFKPFMCIVLLECSRFKYFGFDYSKHSSPFKLEDSFFTPLRYLDTMKYFSLENIIINDELLMFVLESATIKTLEITKFVCNYDFKHFLKNKTLNHNLRSISLTHSLSKVDSNLILCIERFYGISHLKLQNIDWISSKTKSFHEYIFRLVSYKDNKIYLKCLEIDEALNNNKMFNNLLFLSETYGYTNIKKIEYRVYEISEIEYSFFNQMTKLENIFIEVRNTTASINFKKLFCNIELFNTIILISIHVNRIFKEDTGIFKKFKFLAILYFEFKILDFDTISNIKKRDFKNIQIHISPNRAERSVEINNYLDSEFKINFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY38</accession>
    <name>A0A4V2JY38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0233p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000233">
        <property type="protein sequence ID" value="TBU18637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0233p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="28155" checksum="4C88F16678C506C6" modified="2019-07-31" version="1">MENVGRIHGVAYQSNEKHNFRENGNNLVDLVHLQGNMSSNNINIKLRAENRTKKKISIHSKNIFSAYAYNNLNEKEIKIIKSNFCAACDEIQKYVRNMLINKKQYILEEEDFKYFSDKENQILIFKINKIRRKAFVSTKYIYAIWRSKVSDIFNKAPLIISFKYMINNNNRRVKPRKGFNLKNLLILEFIAQHHFLEKMKNHDFGDLFFVDFKIISSISYIRLCFENIVLISQFPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC8</accession>
    <name>A0A4V2JYC8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Muskelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0044p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0010"/>
    <dbReference type="OrthoDB" id="2188291at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="101450" checksum="2B67D254FF325A66" modified="2019-07-31" version="1" fragment="single">NIQLQHPLLSTLYSHLNNKKFKEAEYLIKNIKNCKYFKDYINKTGYKIIWYKIPYKEIWPGSRGGHHGVIHKGYLYMYGGWNGTQELCDMWRYRIKGDEEGYDSGGGSCKDIKDYNVNTNMDNSIDNPNTNPNMCINNGTTIYNPNTNPNPNPNMCINNTINNTNPNPNPNICINNNNSNTNNNVNTSPWYLLSTNTKTQNGPGRRSCHKMCINPLNDSIYVLGRYLPTEYQRESTWLSSDMYRYDIKSDRWETEGEGDSRQQGDSSSNSRQQGDSSSISRQQGDSNSNSRQHPVNNSISISSRQHPVSSNSSSTDSLQGVSNSSSYYSSSNSSNTPLSTRTVNNTPINNSSSNSSNNTPLSTSSNNNTPTYTNTPITTYTTRPDNIYDHQMIFYNKITPSFFIYGGRSMLNDTQGYSGLYLYEIISKKWRCIRNDNEQPEFTPWIRGRVGHSVIYIPKGYSSSISSMNGRDFEDMDKDSSKLITTNTDNNLIITTGTNESNTENNTDNTDINLSNNNTNLSNNTNLSNNNTNNNTGTNLSNNTNNNNTDTNNNTNTNNNTTNTNIFSCDNSCLFGNFVEYGEVKRAVKLLLKDYDDSLVIIGGQRGKEIFKSMTFYKIESDSVYDVVDMNFIGGDDRVVVRSVLNGRGEIVCLVSNWVEECMDVYVYRLEDGRWCKCEIEDELYDIYEGGDIMDSRDGDRLDRDGLDRDKLEDIDKLGDIDDREYIRGRYGKYNKDKRYVRDKQGRCDKDRNNMCVGGKDKVPMARSAHVFIYDKDTDSYYLYGGNVSTENGDKRVSDMWRMKMKGIEMEKIKVRIVFLIRKYKFMCLLGESIEEALKYLRSEVFERLCCEIYKPVRCVSVCEVIEEIGLYFNKSMCMPSENIEDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG7</accession>
    <name>A0A4V2JYG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0002p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="63" mass="7520" checksum="6B18A144C96FBB5C" modified="2019-07-31" version="1">MFLAQKPLIDKNDEKSYQENDSAKTQSKQRPNFLDMNSKRKRVTLNFAEIISYYETESEKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVI3</accession>
    <name>A0A4V6MVI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2269p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002269">
        <property type="protein sequence ID" value="TBU08382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2269p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="23941" checksum="B9865D942A2FCCF2" modified="2019-07-31" version="1">MEIDPNNSLLSKYTEICSAQNIIKNEEPDIIIDSNFKIDHRIALFSFISLTIVRLFISICLEQSFRMIGMLFSLIAIFISFNLKIENFSGFYELHENSKKKLFFYLETHEFIKCFTHCYIQDRNVFRDADGMCQHCNKFGKTVDLLATRCEKIVSISVIRQLNVRVTNKTFKTSEKEENDEPIININKDSFLEKEEYMAVKEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL3</accession>
    <name>A0A4V6MVL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1238p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001238">
        <property type="protein sequence ID" value="TBU11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1238p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18749" checksum="85C971CC3883671E" modified="2019-07-31" version="1" fragment="single">EKFRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEQETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM8</accession>
    <name>A0A4V6MVM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0595p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000595">
        <property type="protein sequence ID" value="TBU12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0595p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38071" checksum="16CFAE84C92FE9A1" modified="2019-07-31" version="1">MGRRKKVDSENIKNKKIKAVNNLENRAGEILMCDVDVAMLSERLPPPQTFHNTNHQAVVARLAHQRHDKPQYRCHFIRKSTDSIALNTKWLRSAILAVQKRFERMPRNGWPATPRYYNEKFGCTLDIDAFKKLAQNEAEKEIRQEENRERRRIATCLTEPCTLTDTTDKIKEISEKEIGKVVVRTRKLPSELVDTKAHVPESITEAAYIMQTAQVCYDEATREEKLRSAWKENIESKISKLVLSKDLPEKARKQEMLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQSRKENRMFKLFRGQFYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0N9</accession>
    <name>A0A4Q9L0N9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0867p0020</name>
        <name evidence="5" type="ORF">CWI38_0299p0040</name>
        <name evidence="4" type="ORF">CWI38_0348p0030</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000867">
        <property type="protein sequence ID" value="TBU00894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000348">
        <property type="protein sequence ID" value="TBU13740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000299">
        <property type="protein sequence ID" value="TBU16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0N9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L0N9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0867p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0299p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0348p0030"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU16189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="203" mass="23916" checksum="F82141532BF6A745" modified="2019-07-31" version="1">MSPEEEEKNEENPSILKLHIYTSRKYKTDVLQPQKELTDGNLRSSSKYKKERREIVSWSDEEIDALQKGVEKYGYGKWKAIFLDLDFKFHTSRNPSDLKDKYRLLTKKTSYYALKKQDFVVVDNEWNYLTDSLGKYDVYKEKFPHDACERAAILHCKSTLDGSIIRLMSLSNQSVMHVYEVFIIEEGCNKYKVRKISTLTRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3K8</accession>
    <name>A0A4Q9L3K8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0572p0030</name>
        <name evidence="8" type="ORF">CWI38_0014p0060</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000572">
        <property type="protein sequence ID" value="TBU02034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3K8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3K8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0572p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0060"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="230" mass="27421" checksum="B346A0A9F0388F33" modified="2019-07-31" version="1">MDPMKSINWSLAEKRTGNSGYIKAKRKEFLRNRELFRHNRPILTEEQQLAELSILSLERQTYFNDFEFVDWTNPSTLRNFKSEFIKDFICCGNKFEDFEKYCLHVETYHKKQEVCNKKNNYLDFDALNGINHDNLKEICSCPLSLKPDISVEYLLIHSQKHMANPYFKEFPCPHINCKKVYKNPNGYKYHIKNGHKKNLIPKKYPCSVPSCQKSFKNKNGLRYHLTHFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L5R3</accession>
    <name>A0A4Q9L5R3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0390p0020</name>
        <name evidence="2" type="ORF">CWI38_1100p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000390">
        <property type="protein sequence ID" value="TBU02927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001100">
        <property type="protein sequence ID" value="TBU11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L5R3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0390p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1100p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="197" mass="24040" checksum="C3E530B61C06AC20" modified="2019-07-31" version="1">MKDLTQDYLKIFQHNIKNRKQKIIKIYENILLNLKIPRKKICCESCLTYLNINNTNKVEFPFTICVQCFNDLNIEPNYSISLASIFYRKYMEIHRIKCLKSKHKIFLEMLKKKYKNLKNNELQIINNIKKMIKKYILKIFFYQKIEMYLDVLYEQYQSLYVKYLKTLKDRDFNECMTIKDSLLQIINEIESVNLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L624</accession>
    <name>A0A4Q9L624_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0512p0020</name>
        <name evidence="3" type="ORF">CWI38_0277p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000512">
        <property type="protein sequence ID" value="TBU02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000277">
        <property type="protein sequence ID" value="TBU17634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L624"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L624"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0512p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0277p0030"/>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044716">
        <property type="entry name" value="LEUNIG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL COREPRESSOR LEUNIG ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF FILAMENTOUS GROWTH FLO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61737" checksum="7AE705533515F26A" modified="2019-07-31" version="1">MNESDTNFTNYKDINCNSESTLNILIHEYLVKKEFSGAAKIFKLEANVSDYVESTNSPVLLEWYSVFNEICMVRSGVCTDQDQLSRIEGIMMKLENEKRRHANIIKTDHPVPYPYRFEEDMNIYNRKYAVNDPYAYMPPPQFHPMYGPDRRNIPPEEYHRQYYNNRTPGPEYYDHMKGHMQFRGPREMSPYADQYMNKRSPKPPMNYKQQSPKLKPKIVEIPEKTEQIPKEVNLESNRKTLSLINTFKLHTQKITCMAISLESKYLFTGGSDKFLNIINLRDMKRELNFEPFNKQITDIKVKETRTEIYICVSSLEKELKLFKYKISESAEENRLECISLLNGHKGGILSIDFAEDGVFSVDIDGEIRKWNMKGEILKTVPTGDGVKSICYFGKNSLIVSDRNKVYLMDFYKNEIIRELVKESATTIKRCPGGYLMCLRNQVAVFDENLNRINTLPSAGDKPQSACLLMDNSVLVGCYQNIFQHGIGSVISIKAHDNMVTCLDSIVIFNKCYVVSCSQSGECKIWGYGMRETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L698</accession>
    <name>A0A4Q9L698_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sporulation protein Rmd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0349p0010</name>
        <name evidence="6" type="ORF">CWI38_0159p0010</name>
        <name evidence="5" type="ORF">CWI38_1175p0010</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000349">
        <property type="protein sequence ID" value="TBU03137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001175">
        <property type="protein sequence ID" value="TBU11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L698"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L698"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0349p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1175p0010"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="114"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="338" mass="39546" checksum="B3FCC886640C3DED" modified="2019-07-31" version="1">MDDHKQFRQKISLHNTTQDIPVGKKQARIELRAMKDALPLNILPETQSKESVKIEADLKRVTAYCTAERINLKDLYKNINQNEIFNKATMYFGECLYASIRLPISPNEEQSFDIFYYDYGVVVCWGLQQNNETVVLNHLKKFEENKYEVGKVEVESFRYGIVRENPMVLNDIIYLNTEDFFNKMVISNAIAQSVKLDYFENLVDMTVDTVKDLPEEVENEGKVGKTRKDILKLVGKLHRLRFNLNLITNILDEPEMLWHYPGYASLYETFKHYLEIKPRVEVLNQRCDVIQGILGILSDNINTRNGESLEKTIIALIMFSVVIGIIQIFMFWYYNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LB19</accession>
    <name>A0A4Q9LB19_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0072p0010</name>
        <name evidence="4" type="ORF">CWI38_1217p0030</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000072">
        <property type="protein sequence ID" value="TBU04914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001217">
        <property type="protein sequence ID" value="TBU11419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LB19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0072p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1217p0030"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="168" mass="18821" checksum="CD22DEBD48EBC41A" modified="2019-07-31" version="1">MEIRDFKPNIEKITERSLLPQFGKGISSNIIPNSKPYPSFQTVSTSLSKSVVSNTGDIYVFKPRNRNIGAFSSIASYGPRSTMTSVRITNIPLEITSKELEMIIMKECKLPVIETRIIYTTGSDNKKKSRGFAFITLSSAQNAEKVIQRLRGFKIDLYVIHAELAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDE9</accession>
    <name>A0A4Q9LDE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0011p0070</name>
        <name evidence="2" type="ORF">CWI38_0957p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000957">
        <property type="protein sequence ID" value="TBU11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0957p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="221" mass="25869" checksum="FA3D8DCA3A0B65C2" modified="2019-07-31" version="1">MELELSPHNARILDSLLKTETIIIKISENIIIQELSDSKSLLIQITLFPLFFTEYLQNDLNFSFSFSTPKFFKKGMKSLRIVITDLIISLSWKFNTYNYYKEIYISSTELYSLDFNEIKSINLDLVLLFEIIKYLKSDVIVLKFLENYFIISGENKSEKAVVYMENNFNEILKFPQKNIKTILELMTDTDECMLSIDALKKTACFISKFPEYLLSIFTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEM2</accession>
    <name>A0A4Q9LEM2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_2574p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="PITK01002574">
        <property type="protein sequence ID" value="TBU06449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEM2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2574p0010"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU06449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="47418" checksum="6977482F5B25812E" modified="2019-07-31" version="1" fragment="single">RGVSSSRGVSSSSGGGSRGGSGKSNTSGNKSNTSGNTSNKSNNKTTSNKSNNNPYTNNPYTNNTNNNNNNPTVLKKLKLISNISTNNMVCFDYKGNIKKYENVKDILLEFCSVRLNLYVKRKEYLLKVLIKELIKVSNKVRFIKEVINGSIVICKRSREEVVNELKCKGYVGIIGDKIVGLGGGDVVGDIGVGDDIGDVGGDIGVGDDIGDVGGDIGVGDDIVGDSNNNTSNTSTSNNNTTNNPNNNTTNNTNNTPTNNNTNNLNPDAFDYLLGMQLLSLTVERVDKLEKEYKNKKKEYEELLSKSHKELWKEDIYRFMCEYDKVCNEEDRMYEDECRNRRGGNRCGGSSGGSGRGRGGSRDGVGRDRDGKGSRDGVSKGSTKNTSTKSKTSTKSKTSSDKDILSSDEVVKKRKVSGKKEKPWEKYNVILSDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEV9</accession>
    <name>A0A4Q9LEV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative M48 peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2556p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002556">
        <property type="protein sequence ID" value="TBU06539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2556p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020670244" evidence="7">
        <location>
            <begin position="17"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU06539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="225" mass="25814" checksum="D0D3FA4288EE9FBC" modified="2019-07-31" version="1" fragment="single">YITIIAFGLFLYFSISFKEMGDPTIAGYERIDPTTLDIQIQEAIAKCKLGNDIFVKQTGSFFTNAFFAINFVTKRIILDGEIFKGKYFTQGILSHELGHAMDGRNILFAKITLEILSFVFILFFVDCLVSKYFVDENVSRDCSSAVLFLFYLSYFHVCLKPMNNILSQIFEFRADSFAKSLSQHIPLANSLFLISFTKEPFVSSKLYSALLYTHPSIYDRLKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF03</accession>
    <name>A0A4Q9LF03_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2622p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002622">
        <property type="protein sequence ID" value="TBU06196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF03"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LF03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2622p0010"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="3">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU06196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="21965" checksum="5CD4459E896748BE" modified="2019-07-31" version="1">MVKKIRVHKTFTYNHIIKEAIQSMTDNKATSGQIFDYVSEKHPDLFNNENSTTWKGNIRQLLSKSTEFVKLKKDQHTKLHYWTYIPISEQHMLENIPNKVRKKQPAYINNIPMYQMPIFYNNYNPNDPSHMIPQNTYQYNYPTYPINYTIDELYQRNYYPFYEDSILNRFNENENNEENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHB2</accession>
    <name>A0A4Q9LHB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2391p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002391">
        <property type="protein sequence ID" value="TBU07503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2391p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="10177" checksum="D3C3B86A3069E51F" modified="2019-07-31" version="1">MQELFVGEVKYEEIKRRIFSDVCFRRAVDVNSTVQIFVSRDRKEEEELWKVLIFGIEVEILVFKKFRILGVEILDFKRLEYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL83</accession>
    <name>A0A4Q9LL83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2188p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002188">
        <property type="protein sequence ID" value="TBU09068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2188p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="34257" checksum="92A919BBC9FEE9F7" modified="2019-07-31" version="1">MCDVDVAVLFDRLPSQPTFYNTSKQPPRKVAKLAQSIWLTPYPPNGMTNLKTYAILEGNRLILLHPILTLSRLMPRNGWPATLRYYNEKFGCTLDIDAFKKFAQNEAEREIRQEENVDRRRIATCLADTCTLTDTKEYINLRDKFLSKIKEISEKEIGKVVVRTRKLPSELVDSKVLDLINRIIGEYADSCVPMTITAVARIIQAAQVCYDEATRNIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIIREFNLNLSSVTDLSEALVKMNESLNVYEKKITMRKLEAIPKRESYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMA2</accession>
    <name>A0A4Q9LMA2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2191p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002191">
        <property type="protein sequence ID" value="TBU09046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2191p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="39305" checksum="F4DCBD07ECA8C294" modified="2019-07-31" version="1" fragment="single">FCQALKCFVNLQTLKLNVYIIDYSSNRNIIETVESLKNLEFITIIQRKSVYEVSESHILPSKKSNIKYLHLENIHSTDKYMYRNFFQNNRSLNKIVQVKSRISQYELEEIFALENLDSLSLTLNYFGYDTCPSKMQNIMSTKIVCLNLSGNGSKFLEHFGILGKLDCLQYLKFSDCGFKEGFLKNINEKCSLRMLSLFYIRGSLDIFDFEGIKKLECLESLNISECELLDCSFHQLFENCKFVKSLRRLYLSHVSLNEQDLQCLKTFINLKELSLNLDQFDLPTVHYYLIAIPLKLYISSFVAKKEEGFEKFREYLRSKNINIISRYDCFEDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNA0</accession>
    <name>A0A4Q9LNA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5089 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2202p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002202">
        <property type="protein sequence ID" value="TBU08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2202p0010"/>
    <dbReference type="OrthoDB" id="2192459at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031547">
        <property type="entry name" value="DUF5089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17002">
        <property type="entry name" value="DUF5089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15969" checksum="77F3420973D15E8B" modified="2019-07-31" version="1" fragment="single">KITKDIKREGKLFGFHVPLIGKIKHLFSSDRKIEKEVEVEKERLKHKKNRSTERIQEISSDDEHFNQNSDDEVVKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENSEQIMDRTTEELKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNY8</accession>
    <name>A0A4Q9LNY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2097p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002097">
        <property type="protein sequence ID" value="TBU09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2097p0010"/>
    <dbReference type="OrthoDB" id="1101576at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="12319" checksum="D63D7E3CC2B43450" modified="2019-07-31" version="1">MLGHDRSFKNTNNCTNHIKFKVHNHRQFLKLIEEIEENDWSCSTVIRWISCGKVLKLFSNLKNHQNIFTLKDSPLVVLLNNEWLWELALNIDLSKQMNDLSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP87</accession>
    <name>A0A4Q9LP87_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2076p0010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="PITK01002076">
        <property type="protein sequence ID" value="TBU09997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP87"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2076p0010"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="291"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="721"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="900"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="901"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU09997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115061" checksum="E34788EBB490C9DC" modified="2019-07-31" version="1" fragment="single">MNINGFPTKISFSTYNHQQIKELSKIKITTSTPFDTLGNPIKNGLYDTSLGPLTNKETCTSCHLNFFECPGHFGYIELPMCVYNPMHFDSLLKILRNSCLNCHTLKEKLVFSKRKNINSDIDNGENGDIDLSDTENTNIDYTNTYHTNTYHTDTYHTDTYHTDTYHTDTYHTDTYHTNNIPHNIPHNIPNTSINNNILNTSINNNIPHNIPHNIPHNIPNNNNHFTVDPLKILFKNTHKKCKKCKQKTPQITHHKHLYILINNTPTPLLQIQTHISKLYLKENHHPFLNPNIFFLINIPVTPNKFRPLSYINGNTFEHPQNIILSKIIKVSEELKEGTGNSGGMDRDISNSGDISNRDISTRDNSTRNNNIKDTKDIIDTKDIKDIKDIKDIIDTKDTITPLVSSLQLSVNMYYDSSCVRVKGKTLLIGLKQLLEKKEGLFRKNIMGKRVNYAARSVISPDPCLHTKEIGIPIEIASKLTFPEQVTPYNINRLKKYIINGNSYPGAVLLENKNIITHLQYIGLEKRIALSNSLSYVCGGGVCGSFGGSNNGNNDNSNNGSNLVNNNNTTNTIVYRHLLDNDYVLVNRQPTLHKPSIMSHRVKVLKYEKTLRMHYANCNSYNADFDGDEINIHLPQDVISQVEAQMLSCTDSNYTVWTNGSPIRGLVQDHVIVGTRLCMKGVFYSKREMEEYISEVRGGDIGVGGDIGMGGDIGVGDMIYGSSNKDSNKDKYKDKDKDKDKGYNDNNHTNNNTNNNTTNNITSLLLIPPAILRPVRLYTGKQLISCILLSLNIKITYKGKSKVPFNCTDKYTLIIKGYLLTGVIDKNQLGSVNKSFIHYCSVIYNKEICNELLSVFSRVFNRIMVSDGVSVGIKDIMLCNDFKRSDMIKVCRERGRIKGEGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGGDYEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPA1</accession>
    <name>A0A4Q9LPA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1911p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001911">
        <property type="protein sequence ID" value="TBU10248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1911p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14471" checksum="ADF48DD9DD40E9ED" modified="2019-07-31" version="1">MPKLVNLIFYKVSFDSNFKLIFGLISPDRIIGSVHIEYCSLSEDDLRYISKLKISSLILIHTQKNLLQIYYNLIEGVIKDTLVMLKIYDETETNVAAVNLYLAKFVKLEIFIVNDQKYDLYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ41</accession>
    <name>A0A4Q9LQ41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit alpha of signal recognition particle receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1972p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001972">
        <property type="protein sequence ID" value="TBU10166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ41"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1972p0010"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="6">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="19999" checksum="E262DA823538EA6B" modified="2019-07-31" version="1" fragment="single">NFKVYIAACDTFRAGAIEQLKVHVQRFKSAGYEVGLYEKGYNKSDATVAKNAIIMAKSENYDVILIDTAGRMHNKKELMISLSKLIKTNNPEHLIFVGEALVGSDSLEHLREFNRAVGEGITDKRLDSILLTKMDTVDDKIGQIVNMTVAGNCPILFLGTGQTNMDLTKIDIKTVVDSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ70</accession>
    <name>A0A4Q9LQ70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1825p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001825">
        <property type="protein sequence ID" value="TBU10357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1825p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17051" checksum="C839150FD845D38B" modified="2019-07-31" version="1" fragment="single">GLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG4</accession>
    <name>A0A4Q9LQG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF933 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1558p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001558">
        <property type="protein sequence ID" value="TBU10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1558p0010"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="YchF C-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="34717" checksum="5CFD84C7E6AEF6ED" modified="2019-07-31" version="1">MISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIMSQQGGNDIDKGKSNISNKDSNIGISKDNNTTTNTTNTTKSDINTINNNPIPSDFTLSNEEVLFISTLNLLTTKPVVYLANKVTKIIKIKKYLKSILHVKPIIFSLEEEGTKVLIDKMVRMGCSVLDLITYFTVGSVIHKDFEKYFVSAEVFNHKDLHELGSEADVRKKGKCYTKRNMYVVQMGLLYTLSLIPLKWVGVVRTREKVCVRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ2</accession>
    <name>A0A4Q9LQJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1565p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001565">
        <property type="protein sequence ID" value="TBU10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1565p0040"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19394" checksum="454A77698021D6C7" modified="2019-07-31" version="1" fragment="single">SQDSLQIVEIEKLRKYNLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRQRGLESGPNAEESWGRASLSVILGAEIHKQPIPPLKQVDNEDDDVKKENTKNILPLILDGITTAKEPTTNTNEELEEEIEVVEMVEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR60</accession>
    <name>A0A4Q9LR60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1615p0020</name>
        <name evidence="2" type="ORF">CWI38_1431p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001615">
        <property type="protein sequence ID" value="TBT98750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001431">
        <property type="protein sequence ID" value="TBU11009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1615p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1431p0010"/>
    <dbReference type="OrthoDB" id="2191424at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="302" mass="35960" checksum="55B577F7131578BD" modified="2019-07-31" version="1">MKDRIRKSLLPQTNNDYIDEEYLIGRINEHLMIPNTFYRKTLLITTKRYNFKGCPLDAEKSNKTSEISLKSKETVGFSYEGKIFQNKAAIMEFSISEDISFCQIYQKIKELGYTNVPDIQNLTLFKNIEPPFFSSRNYVYLEKNNSFLKNYDKENWFKENNLNSFNHQYQSNEVNYFKNKDQNIEDSTKRILKFFDWNTPLRLAGLYIYSEILCVDKNFMLKFRFERINGSFDIKKNFVFYKLPSKKLVCRICERNLADIKVLDDPILPENQKIICKNCFEAIYVDNNGDLRYPDIIISKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB6</accession>
    <name>A0A4Q9LRB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2062p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002062">
        <property type="protein sequence ID" value="TBU10055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2062p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="622" mass="74698" checksum="7624D66D4920F8D4" modified="2019-07-31" version="1" fragment="single">FLEYFRVKDDNKLRNVIKSILYSLVESGEMNNFNIEKVSFHFSKQYYFSHALFKKISQEYLKLLNNGKDLKFSFFIKEHEYDISDQYKGIFTEDKKHTLVIDDEFNTFFDKKVVVNHKSQCIFLMFLNTLDIKYLHIKSLKRVNRKSFCFILDNLKKKIDEIVFFWCYISDDVICSLNANLNFKNLKKIVFIESNFDTVFIFIEHLSNIEEFIFYINENYEIYTVTGIEEENLNIADLIIQSLKNEIQKYSLKESINKNEKIPKENEDFHLKLLNEDKFRDKVKIFEDFRCENNNFEVQCFYEYKGCFNNMSIYLNILNKNSFFATENTILEQTIKSISISSSVIKSDCLKDILNIKGLERLEIEYSYIDIKNEIFLNESIKYFKFWPSDSSCYSDFFQLIDMMIGLQKIYFDTTNTIKLNRFENQIFYITELDLRCFDRMIDFLIQSEQNEKFDFEATNKDGENLKLYLSPLKFLFQNYEISSIKKLSISDFYINNSDVEALCNLLSLEELNINSIKFENISFSELFLAKQEYKIKRMNLYGINISEKDLIFIANLKKIEYIQFESCYIQGNTYNEIKMSFFNENYIELKYNARRDNLPEKTIKFIKEKFNTKILLQSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN3</accession>
    <name>A0A4Q9LRN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1583p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001583">
        <property type="protein sequence ID" value="TBU10726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1583p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="24382" checksum="0A806EC865E3CA1F" modified="2019-07-31" version="1">MLLSWSTVVRETGISRSGRGVGGGVNNKGRGVGVKRGVNIRVIIRVVIKGVLAELSNSDCNYKGVIYEILPGNFRVAVLNKDEKKCNLKVLVIDKIHELFNEKGTLNTEVLYIQEYSSTCKFSSKGSIRLPGFKREIKIQLGRTLPYSCKLFLRKCDNETRNYSLIFSLSDNDLVEFEIISDKNLSITKIVEMTEKHPIPKELSHLLLMNIQSEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT0</accession>
    <name>A0A4Q9LRT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5092 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1317p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001317">
        <property type="protein sequence ID" value="TBU11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1317p0010"/>
    <dbReference type="OrthoDB" id="2189509at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41044" checksum="79137D21B644CE9E" modified="2019-07-31" version="1">MENTFEEFYEKIKNISTEIRVLGGPDNASSFNLTELDTVDADEPETFTLEELKNLVMDFKKAGKDFILARITTPDQYRQEHLYNYYYSASEVNKLLFKYESDRRLLHRMKVRNPLNNMFIIGEVYYYIITKQEVDRAILDFYFCTDEKPKDEETRSFSAVFRTSNVSLNSNIYDLKKAKDTDNCIRDKDHTDIIEGKTPEEIIQDIQVGNLKLPPNIPDTKKLSYHAKYFATDDDFLMKTEVRDIFKANSMDPDEEFLFELDRTQNDLFALLDTTSDSENENVVGWKRVLTVHMSMLITMLGVVVLLGANPIILLIAFPLAILTLISFLCSLLYIVFFRRSTFGSLAVRSVDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ6</accession>
    <name>A0A4Q9LRZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1424p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001424">
        <property type="protein sequence ID" value="TBU11027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1424p0010"/>
    <dbReference type="OrthoDB" id="2187412at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20917" checksum="A82EC2E051CE923D" modified="2019-07-31" version="1">MRKMYTPNQFLEFMVDTNHYYKQFLNYIKIYEQRNSLPKIKLKIMNISENLKDLKVYGYNNDNDVFTVIFHIKYGIIGISTMFRELDAEAMRFIANVPIESQIEQIEIFLSLYYDYKWRVCDLCLSYLSIPHYLPPLIRTIQQNYVSARHKCCDEIKCELDFYSDPEIRMPDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS15</accession>
    <name>A0A4Q9LS15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1494p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001494">
        <property type="protein sequence ID" value="TBU10886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1494p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18210" checksum="D4E916FE90197B3F" modified="2019-07-31" version="1">MLNFSKNTDSFLINASKDLFIDNIYEILIFSVQIMDEILNLLENVVFENLKCIYILDSTIETMNKTFLKKFNHLQKINVICNYFDEENVKSFITNSDLCATVVVKKYIFVSDFDEKILKLVHLKNSVSSQSAKRFIIETNKILEEIEELFFLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS97</accession>
    <name>A0A4Q9LS97_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_1798p0020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="PITK01001798">
        <property type="protein sequence ID" value="TBU10390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1798p0020"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="15">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU10390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="51921" checksum="9D61A32AD44C654B" modified="2019-07-31" version="1" fragment="single">MEIQVKIKEIKSDLITTKCKRKFVFQDKSNEIENNFTIKLLTLHDQLFSSLEVIFYEEGLINANVIGTVIIMVSSIFKGINKYKILHGCYAYDYISYEEVCEKGIGEICFDINIEAIDNSDDKPTETHPLFMGMLYKMFGSSDYFNRIVAIKNILLSAIKGSVSCRFNFLRGLIPLEKYYTFEYENILSRFEPGSVLETRSLSQDTGMEKENGHSKILLHQNGSVSIDCSYKNYEKTNIHEDFVSETGDAVPLLDQDAGLLQKLGHEDINLGYGTMPRDFIIKYRKNFYFSVASYGQAFLILKFIKKQIKVDPEVKEPTKTILEYLNIPEELLLRINLNHSVPHLIFIDSDENNLVISFKGTTDSMDALNDLNCEYSNFYEGYSHKGIKDLALCFIKDWKDFIIRIIKIYDLKGLKITGHSLGGGIAILVGIILYKENVLTENEIEIIAYSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM1</accession>
    <name>A0A4Q9LSM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1151p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001151">
        <property type="protein sequence ID" value="TBU11539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1151p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="672"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="736" mass="87047" checksum="77BB570B16B13D66" modified="2019-07-31" version="1">MKRRQSLRSILIHTPKKLKREEINRSEYKTSKNTNYNVNSALIRENDENFSEKENILEVNIKQGNTFELESLIEISNQTNNLIDTNCKETEEFNQNKFFISKEKQENIIGENTKFDMRENNKLEINTNVIGENNKLEINTNVNGENIAMMICDREVFKEKKCETEVNIINRNYDLSTKTFELNEIIYESNSLNSIIDFTKEEMNSFSHLSSLSSNHDLNHKICKEKKCKNNLSVKIKESKEMYENKISNRLRISSAKIEEFLEFQNLNNSNFENEKSNCLGISSAKIEEFCEFQNINNSNFENEKSNCLGISSAKIEESCEFQNINNSNFENEKKLPLKNIKENKILNYKNDIECPDIINNENNYNLINPIENDIECPDIITNKDSYNLINAIENENYIEYPEISNNKDNHSLINTKQTDKKIRNSEIPNNKDNHGLINTKQNHKKNENYKPRPPKNNSIEIEKLNEPENNILEEILLSLKNIYNLFGFESKKEVKSIKEIKLMITELFFCLKEKFTEECKETFKFEKEMIKKFLTNLFKTDKILETIESKKKYKKNKDLLISNLNQILETKNYLSLFDWIKDILNYKNSIHLKYISKLEKEFNKKINNYGSVNNKLKLEINEKDQQVCKLQSEYDLIKEKLKTLEYLKNIFCTKDLETYIDKGTDILKSIKEEFTNEFKQLNTRNTILEKENEKMKLKIQNLQEIIENLVQKLSKKKNAQFIIEDLKKDMEIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN1</accession>
    <name>A0A4Q9LSN1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)</fullName>
            <ecNumber evidence="3">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1697p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001697">
        <property type="protein sequence ID" value="TBU10530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1697p0010"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24137" checksum="E6EC7E9D7E8B09AE" modified="2019-07-31" version="1" fragment="single">EDKSEQKGTGRWCVVASIENTTPSTLMAESVYSRFLSNQKDLRIDFSKKIDDCLEITNDINLNEDDLKRTFFMAKAVSYVQGFNLLRNGSKNNNWDLNLPSITRIWRNGCIIRSNFLEVIENIVQEVDENFELSDIFINICKQNIQNLRKVVGFSICKGIPVPVLSACLEFFDILNTKRGGGNIIQALRDYFGSHMVRFLGKDEDEHVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT24</accession>
    <name>A0A4Q9LT24_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1279p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001279">
        <property type="protein sequence ID" value="TBU11296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1279p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25867" checksum="C573FFB6B4B94596" modified="2019-07-31" version="1" fragment="single">DINIYSSSRNSNIFSIKTDTINIKLFHLRSLKYSATSFSDYAEPIFPKLPYILQIELGSNFPKGTLHRIFYQNYFGSLKRLNFDGAHLGKEDEFAFGNYINLFSLCFSGYSKCSEIKFSELFDSNNIYSLQELKLPDIEITCLDLQFLSKINCLKKIYIYSLASQVHIIDFLKLLLFVQEIQIKKLSVYGNEIYEQFGTKPVYLIWMNNYENLKYLSRCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI3</accession>
    <name>A0A4Q9LTI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit beta of translation initiation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0985p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000985">
        <property type="protein sequence ID" value="TBU11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0985p0020"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="6">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="34382" checksum="CE824217283C251B" modified="2019-07-31" version="1">MKRVDIDRNNKDPFYRYKMPGVMVKIEGKGNGIKTVIVNLEEIAHSLRRKAVHILKFISYELGSISFFDSKNGRYIVNGSHDTNKVQAKIYDFIEIYVMCEVCRNPETFFVYEKTLKKECLACGNSCKVDGHTKVDNIVAKDLENDSSFSERDKSYYDLTVNIGDQNMELKNDLKSLLDANCSAEDIYKCFMDNKESIDIFYQKVFQIIENNPRKILACSILINERKDGCVEIFKALEIYSSEKKSFDFIFISLQAILDNKIVKRSECFKYFQTKSKYVSEEDSMNIRKALSPLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK8</accession>
    <name>A0A4Q9LTK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1182p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001182">
        <property type="protein sequence ID" value="TBU11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1182p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21479" checksum="2611010EF1B130E2" modified="2019-07-31" version="1" fragment="single">DKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKNKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP6</accession>
    <name>A0A4Q9LTP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0944p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000944">
        <property type="protein sequence ID" value="TBU11998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0944p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="332" mass="38827" checksum="9CF409F13A8C9D70" modified="2019-07-31" version="1">MNYKNWLVLPDTSSNTKKTNKMNIKYFTLNFSKIIRSVSFLPFIILLFNIGNCIRITISFTNEEHPKELPPLQPSSIYPKRRKHNPEISVNRKGQTLSNYKNKYMEQIKNNKYLNTPPSNKLKKSIDNINEGKGIIIKNSSGDGNYACLSTSRYIPWSEIIADDSNLTNSEDNTDISSEEHIDSITFDYSSDFIIRSKYLDCLNETNIEELHLNIKDITECKIDSVLCEMLLFILPSGLDFGFPNLNNENFLEFIWFLNDISCYSKYDALETFYKNLLPFLYSYVTYINSKMPEESREIFYIHKKQLFPFLAVLYDTIDLYFDENTNELTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS1</accession>
    <name>A0A4Q9LTS1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1355p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001355">
        <property type="protein sequence ID" value="TBU11151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1355p0020"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="381"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="713" mass="85723" checksum="5BD50363FB92A9B8" modified="2019-07-31" version="1" fragment="single">NFDENVVLKGLIFLCIFSKPEDFIELIEISKKILDTYSNLECLERYIESIAHEIEDSKLNEGNEMYFGKLEGFKKIATFFMSNKYFIKEDLLFELLFLELFFFDENERYFSGIFFKFSEITHEFLNWMKYIKQSKRQNIVFEILNTQNKISKCVLGDLLNIFSVYLEKMRFYLISKYFYSNLNSSDPEIKHFYKEADNFFSLLNQINFIEKYDKSEIIFKFFDTIRKNPLIPYFINSLDIENEIFIYLFDIYIKIIEKCCQIYFIIRQRVFNFKKLENYKKYFISEDFICFLFEIDHFESKFRNLNEKNIAKIDNLISFFYRIKNIFSNFDKIFFNFRCLSLKTKLLLIPKPDRDQNLLFDSYVFLQIDRNNIIESTIDAFKNFSNEIFSQKNWFVKYSNEEGSGIGLLYEFFNIFGKCIDESDYFAPFKSLEFIIICVSSPEEQNKIEQLYYFTGVIMAKSIFMNSVMSFEFINSFYLYLLQEKFNIEDLKDIDFEYYKNLISLRNVENHDPDLTFDISVKIGQKIISRNLIENGSEIKVTKDNLEDYIQKMAEFKMFKGMEVYLDKLKEGFQSLFNHCFYNMFTHSDLKIVIEGEKRININEWKAATRYGGKYYTDHQLIVWFWNFLRKSDEITKRKLLFFTTGLSYLPIGGFKSSKFIDHPFTITSDDRKDLFPRSQTCSNLLILPLYDQEDVLLDKIEHAIEVINYGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW1</accession>
    <name>A0A4Q9LTW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1051p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001051">
        <property type="protein sequence ID" value="TBU11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1051p0010"/>
    <dbReference type="OrthoDB" id="2742885at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="449"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="922" mass="106481" checksum="5E6729EE38E23C96" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQKEKIIKAANRASEVDEVIRECKNDQGIPQPSSYTPSTIINNISIPPSEANTNTKVYLLNTIPSPSKPMHSSTVTPRPDIAASGPNLCTIPISERLVVLRSILRSIEAERQEFIRCVFFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPLVVRTRKLPNELVDSTVLDLINRIVGEYADSHVPMTITDVARIIQTAQVCYDDETRKERPRSSWKESIESKISVLKLSKDILEKARRREELSSSQTKSLKKIMREFNLDLNKTNDLSKAVVKKNELITIYEKKLTMYESRKQFRKENRMFELFRGRYYRGLSERVESEHVVNRDEIVSFWSKMWNKNNEMVTYDEYLIPFVPDTHQAMFPSLEEFVDIINWLPNWKAAGIDGIYNFYIKKLTTLHKYLYDIVKAICFEGTPQANWFYHGLTYLIPKSVPQKGSDYRPINCMSNLYKLTTKCVTKFVQLEVERRGYLADNQLGAVRGVQGAKEQALLNVAINKEYGNNLKATWIDVKKAYDSIDHAYLTQVIENLNIPDWILKFIKVTISKSKIDISVGSEKIMNKKIDKGILEGDSLSPLLFVLCMDPLSRKLNEEYAKMTIQTEDASQSTNHLLFIDDLKLLAKDGTTLEKMTEEVKMFMKNIGLEINREKSATNDSYYENTATLLEGIGVYKYLGIIEDSRGIPTRKSFEEVQTKLIARVERLCRTRLNARNLFQVINQHAISLINYHIGVLRLEPGDFSKLDDAVRAILIKNKIHLRPGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEVTKNKLKEAQLANLYNEIKNRKLHSKLYSAKNNQLVSVNDPSGWLKKGSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU40</accession>
    <name>A0A4Q9LU40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1018p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001018">
        <property type="protein sequence ID" value="TBU11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1018p0010"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8232" checksum="6574869F3E360159" modified="2019-07-31" version="1">MCVIQKDSMHYEPTTALKQGENDENGGKELKTKNNAPPISKGGTRYEEMTINIKEESDLEEEAIVVKEVKSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU65</accession>
    <name>A0A4Q9LU65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0860p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000860">
        <property type="protein sequence ID" value="TBU12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0860p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020504635" evidence="1">
        <location>
            <begin position="26"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="555" mass="65110" checksum="00BD2F6A11BA07C7" modified="2019-07-31" version="1">MFLSRLHSLHYFILKTALIITFTSSSSSRNKAETGSKIINEEGTSENILITNEQEKILPLQHNHTLTKSQDNSLGHNLLNFNSNNLQNPESEKQNFQHPAHSICVQRFFELSSSYNRLYRYEFRSDSPSQNLDPGYCVYNPSVSSYSDQGIEYQSKNTLIGNNVLHNLSFDKNLLIPQPMSIESQQIRIAIIRILEYPSAGIYPDILILLTQAYFLDDILDPGCLHKYFLVLRNLVEIEKQIISINPRKEREFEQVLHANMENVDLSGSNTFILLYAPTLISLKNFIERKLELYTSYSKNPISIFFGLKLIESVIIKTHKAISMILELHTLNNFSNATSYMNIILKKNSNIIYEIIFQLFSSAFGFNEHFKTIFQLIIDLQKKKCADILSAKKIIFDEFGLSFLPDIFFFLEESEINEIVGLYLKKTNFQSLTGITENHRPIDSINYEIFYLKNKTILKIISYYFMIFEDFEIRLFKDYFLYSKLNNQYLILKRRFEGFKHNLFLDDIRNGNNLRVLLYDTYCFFHYLIVYFYNRDVLPEDYLTKISNIYSIKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA5</accession>
    <name>A0A4Q9LUA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1039p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001039">
        <property type="protein sequence ID" value="TBU11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1039p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="14611" checksum="AA83C33442C4A5B2" modified="2019-07-31" version="1" fragment="single">MSPAPSLDRVPGANPIPVPDVDAVPDVDAGVGVGVDAVPDVDAGVGVGVDAVPDVGVGADAVPDVDAGVDVDAGVGVDVDAVPDVGVGVGVGVGVGADAVPDVDAGVGVGVDAVPDVGVGADAVPDVDAGVDVDAGVDVDACVGVGVGADAGVDVDAGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN6</accession>
    <name>A0A4Q9LUN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1186p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001186">
        <property type="protein sequence ID" value="TBU11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1186p0040"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="313"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="526"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="745" mass="86912" checksum="D3C2EC9DEC92CA24" modified="2019-07-31" version="1">MTSSKSCGFVGISLEIDTRANLINIGLSINDGFFNIDSEKIQYEIVKDIGIEYVCIEDNFDFVKKTCVDNIGCYSIKTNGHVKIYRDILCRHEWEKINLDDLFDKRIYYEFMRYKNVYFDTCYFTCDFENYLCMSCNRKIIIKKDTNLEEEIEKFKITDKYFIYNYDLLIDTFLQIFKRLFKWLREYDEKNNMKIVAIGLSKDLKYYEKLCNEITRIMWGCFDAFPCFYSTELDSNVEEIADFLARQSTRLIGINNLLRLEIGMRNVVEVDSNIISICNLTDYEYSLGPIFADVIELIQKKSEIFNFKKICFISSTPRGGGVALMRNAHIRFYRLLGLDVSWYVTIPAPSVFKITKQKFHNVLQCVAPEDEYLTEEDKILYENWVKLNAERFWTDSVFKETDIIVLDDHQTCGFVKYIKEVNKKAKIIYRSHIQIRGEEIKNKKNLENTWNFISNNLKEVDYFISHPIESFVPHDIPIQKLIYHPPSTDQLDGLNKFISTDICQYYQNLFNIACCESNQPTMDFNLPYIVQIARFDPSKGIIDVIDAYVIYCKKYANKDNSNIPRLILCGHGSVDDPEANTVYNNTLTYIKDKIDKEISSTIICVKIPPSDQILNVILRKAKIALQLSHSEGFEIKVTEALLKGVPVIVYNTGGLPLQVSHNVNGFIVEKGNIQQVAEHINFLINNTEFTLNICKNTYRIINFTTPFQILAWLNIFEMALNNEKGNGRSIFKEIYEKYILPKTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT6</accession>
    <name>A0A4Q9LUT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein Rad50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0795p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000795">
        <property type="protein sequence ID" value="TBU12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LUT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0795p0020"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="11">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="721"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="855"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1436" mass="170685" checksum="074F356F028B9FAF" modified="2019-07-31" version="1">MSSIQKLMIRGIRSFHPNTANYIQFYSPLTLIAGPNGSGKTTIIECLKYVCTGELPPNGRNGAFIYDPKLAHEVDVKAQIKLKFLNLHKQTIVATRSLLLTQKKSKVEQKNIENVLLLKTDNGECISISSKCVDMDREISFHLGVPSYILESVIFCHQEENTWPLSEPINLKKKLDNIFCSTKYTKAIESLKSCKKNSLVELKLKKQQLEFNYSMKIKKENLESKIESTETYRNTLMGKVEIIEEKEKELIVKISMKEQELEKYKKMEKNILEIENEVKSLQMFENNLNLEFKSIESDISLENKCITESELKVFLDENNLNLEFKSIESDISLENECITESELKVFLDENEIKKIENKIFECKNEEQQHNIEYEKIVEMKSKIEMKIEKLKNLESEKSKYLNNKDNFYKIFYEKINSVIIEIKNDDFICKILNKQEILKEFYNLYNKIVSENDIENRINRVDRVDNSNNNYKVDNNNYKVDNNNYKVDSNTREKHCINTNTDILIFINICNKLYEKILLYSNNSLIKNKEEFLKKEEKFKEEIKKMDNFFNEKNNELIYNKNKLNTMQDKLNEIFEELFNEYKTVKSKYNRDSGVSNRLENKNIEQRFEEKNIEQRFEEKNIGQEFEEKNIEQRFEEKEAKLKYFKEIFSQFLIVSETFDENDCSLFEEQKIIAKELEEKQIILNEALKNLEKSFYYKNLNKKKLEIERNVDINCEYSKELVELNEKIKNNKNKLNFLLKEQERWNFREKQRSEKIKNINEQLLSIKYEINQLNIKLENKKDCFDVESIEEIQDLSKNLEECNNALAATENAHLIYKNFQKLGYKKSECPLCKKSMSVPEKNEFYKRLEIVITKIPETKNENELKREELMNKKNKLEIKNEIKKEKNQKLEIYKKLSKIYEKMINNLEEDDSIEEVDSSFLKEEESNNYNDMEFKHSEIPLYLNVLEKEMCEDDIKQRILEKNIKLKNEFEEIIYELKNEEPEVSIEKIQREYNQIKEKFDLNSRKIEIRNKNLEKFNFKSKIENLENQKNILSNSISILQKIIENTNIDALECERKNKIKIFEDEKQFYNEKLQKTNECIYKYKTLIDGNKNIKKEIEFILENLSKIEEEMEKNGFDSKNPYILKILKDDVGFRENLMKIKSNLVNLNNLLNRKKNNFKKAKIILEKRENKKKINLLNKKLKEFDFKELNSCKETLIKLQNLKNNFISEKNHILGELKQINSNLKMFKTELLTEYPETLKKYLKSYVECKTLDLILNDIEKSIKALDKSIVDFHSVKIAEVNQTLKNLWQDTYKGNDIDFIELRSESIGTKTYNYKIVMIKNGIELDMRGRCSAGQKVIASILIRLALADSFASHCGIMALDEPTTNLDKENIEALAFTLNQIIKERRNNNFQFVIITHDEEFVKMICKDDGCEYFYRLIRNSKGDSIIERHSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY7</accession>
    <name>A0A4Q9LUY7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="11">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0047p0090</name>
        <name evidence="14" type="ORF">CWI38_1207p0020</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="11"/>
    <dbReference type="EMBL" id="PITK01001207">
        <property type="protein sequence ID" value="TBU11435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1207p0020"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="13">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU20596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="470" mass="52082" checksum="8ED50DD7887CE374" modified="2019-07-31" version="1">MIFDLGKSIASSLNSLLKTQVTDSKIEATLHDICNQLLSSNVSPKYVDVLKQNIRANVFSKEIPAGVNKGKLVYNAVYDELLKMLDPKSAPIKLERNKTNVVVFVGLQGSGKTTTVCKYANYYKKKGFKTGIVCADTFRAGAFDQIKQNALKIKVPYFGSSDPDPVKVAVEGFERFKKDKFDLIIIDTSGRHTQERELFQEMKNIITKVTPTKIVLICDAGIGQSAEIQAIGFKNEVDVGSIIITKLDGAKNGGGALSSVASTGCPIEFVGIGENMDDIESFDAERFINKMFGLGDVEGLIETVKKLNIDEKEMMKKIGSGNFTLGDYYDIFQQIMSLGPMSKMLSMIPGFSNMPIPDEKDFRKMIYIFDSLTEKELNSDGSFFEKQPSRIFRIAKGSGTSVENVQNFFVQFKTINSVMKKVGNNPGMMDLFNMDPAKMTTTQKAKLRQKANGVLPKDMVDQLNMFLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC5</accession>
    <name>A0A4Q9LVC5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0685p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000685">
        <property type="protein sequence ID" value="TBU12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0685p0020"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="26912" checksum="F58FAC543B49DCCA" modified="2019-07-31" version="1">MQNVVSYKKKSEHFTLLGDDICFRRRDHLIRAVFGYKTALIKQIIQIKHAVAHIGVNKMMALIAQKYYGIPKEYIKEYVKECEACTNIYKSYYQKYDLFMVDYVDLMGYADQNDHYSWILDDIDTYTKHLWSEHINNVVCAYNRRIHGVTNKSPFMLFFGQPVPAIDIDPDIVLDLEIASDVHEEFTETVTTTTTVIAYDLEIDSKIRSDVAKHFKNYRERIIESNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG4</accession>
    <name>A0A4Q9LVG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">La domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1107p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001107">
        <property type="protein sequence ID" value="TBU11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1107p0040"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="355" mass="41602" checksum="8C6159FDF92AB1B4" modified="2019-07-31" version="1">MTIENLDKVKKQIEFYFSDSNFRVDKFLRTEALKNDGWIDIQTILTFKKMKEYNTTLEMVKTAMNGSTLVEINDDKIKKIESEKYKEYIMKEEHSSSFAVVKGFDIHMSFEEIEIFLSEFVKPRLIRMRKDRERKFNGTVFVELGSEEEINEFLKLKIKKPILKNEVSLPEKNEDSVTKHDDDIKEEKIDSEKETKEEALVEDSLSEDAILKNKGTGKREREDAGEDCDRIKRVKTEANDFLVLIKMNDYLKEVPSKPTESEKLIKSMEGKFYKFEAEGSIDIKTVKRIIPGVAFVDTQKNTLRFKHVPEFETKDFESEDIKIKVTKLNKTESDEYTSGLNLKPKPVKKGRRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ8</accession>
    <name>A0A4Q9LVZ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1034p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001034">
        <property type="protein sequence ID" value="TBU11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1034p0040"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="357" mass="41350" checksum="6A90CBF8386F25C3" modified="2019-07-31" version="1">MVVKITDEEIKQNEFLKNRYQILEHSGEGTFSTVYKAIDLKNSNIETNEVVYVALKNITKTSSPHRVSEEIKFLLSLNGNDNVVPLLSCLRHQDQITVVFPYFEFTDFREFLEKCTVLDIKYYMYNLLLSVKHVHSKNIIHRDIKPSNFLYNFDTKTGQLIDFGLAQYENPKYSKENALKEMTNTPKKKPTILFFGSMVSKYVKPPGYYVSDSRPQMKAQRAGTRGFRAPEVLFRSPCQSRSIDIWSVGVIFLILLTKQYPFFNSSDDIDAILEIACIFGHNEMRKAAKHYERIWKSNINTCPTERITFEEIVAGLNPSCNLSAEGYDLLYRMLDLYSERRISADDALNHPFFNDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW78</accession>
    <name>A0A4Q9LW78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0694p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000694">
        <property type="protein sequence ID" value="TBU12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0694p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14849" checksum="8173CC6E1401EB23" modified="2019-07-31" version="1">MRAEIEMQIYKVIFLSKSKILTTFSDIEDNWKCKSQGHNLIDFRTGYIENLLIFESIFGEILVHGRKYIIKGGNVYERNNDLIEEKETATSEATHAKTPNSRMSQNNLMRLVNIGSQRRTYNFKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC3</accession>
    <name>A0A4Q9LWC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0575p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000575">
        <property type="protein sequence ID" value="TBU12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0575p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021010917" evidence="3">
        <location>
            <begin position="18"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="717" mass="84173" checksum="34BA8928B2419C88" modified="2019-07-31" version="1">MFFHVFVCLKILHCFTGLNIDPMIEVYFRINLNLVLRQNDEIRNILHGISDEINESEMEKYVSVISYYLDIVKENINSVHHPLLTHFVCLIFYLVHHKDTDEPIIFDADLLFNIVTFSKLYEYTKCNREMNDIIKTKMISLFKSGMETKENMKEILKSKVIRLNELETDCPLIINNIKSSFDLDNNMDFQIIKNMKVKFKDLQSWVYVEFYLKSGSFESIYSFFIYLKLCFLIEKWQDLNSETIGFSLNDFFLDSTFWDQLRALNPSLTPYIFLKFDRVTYKDFIKFISATWLNKILNESSSFDSIFEFSEEKFFYGTANISRKFPENFIEFFKVKPYENQINMIYSLLIDISKSEFHQYIPIVFILKFFCFKKVTSNSEILLRVILECIFYMHILSTERNNCNTFSPRKAYEDKLFSLLEKNLTSRNIKINIPVNRITLIQRYIPETFNFFENFILALEFANAASINFFQRSFICNLYDLNRSASQDVYKNLKSYCKYLLAIELDKTIRLATVTAHEPEPIPESITESDTISEYIPNSMPTHETKPKTKDKPKYMPKSLPTPEPVPENIIKPRTVPEFLPESKLKHEQPVLKSIPEPGKNPINVPLEIIEKKQSKISPKDQNEKLASTSVGIKPEISPQTPSKIKIKNKNNRNKLENITKEDKDSTSEKETQSKTLEGKKKNKNNIFKIILIVTLVFISIIGISAIGYWVYVTWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC5</accession>
    <name>A0A4Q9LWC5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0701p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000701">
        <property type="protein sequence ID" value="TBU12596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0701p0010"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="57"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26282" checksum="72E9E84568248D1B" modified="2019-07-31" version="1" fragment="single">MLPPECSHSIRLGNLCVNCGKEVPNTELYSTLYTNSFLKATKKGIKKITEKHTTEMLKSKKLALVIDIDQTILHACPGHVMFGSILPEIHHIFVNSSPITIKLRPNLDLFLSSLSKIYILHIYTLGTREYANKILELIDPSSFLFSNRVMTRSESYSTYKDIQKIFTSNKLHTVIIDDRADVWNYCNNLFLIRPYKYFEYGDINEPISVSTIPDTSVESNTEINLSTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG3</accession>
    <name>A0A4Q9LWG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide phosphatase/kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0661p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000661">
        <property type="protein sequence ID" value="TBU12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0661p0010"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="40211" checksum="FEFB623E0617C200" modified="2019-07-31" version="1">MILDNLLIVKNYDKDFKKYVKIAAFDLDNTIINNLPNRAAEDERGWVFRYKNVISKMNNLHTEGYLVAILSNQSGLILAGTVSKFKRKIKRIMKNFNFPVIFIAALYKDFYRKPSIGMFKFLIEYHILDGNIDYKNSFYVGDAAGRSHLPFNDHSDCDIKFAYNANIEFYTPEEFFDEQPKSHKNIEFFKIDSYRNEISFDTKNFINFDIVFVYGNAVKYCGKTHFSKKYFQNFSILRNPQGISKTNEKIIFFDVYDENLIKKVIRNRKIQNIGVFHLSYDKKVLKYLKRLGELSGKKSESLIENCNENFSSFFDIPIISVPFIFDDTDFSPELRKISQLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH5</accession>
    <name>A0A4Q9LWH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0681p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000681">
        <property type="protein sequence ID" value="TBU12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0681p0040"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="3">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="487" mass="57173" checksum="AE216C5AE9FF4F21" modified="2019-07-31" version="1">MRNRNERKNTLKDITNKEKEESNKKESVSNKSKESINEPSMNNKKSINKVLTDSRESINKSGSKSKESINEPSMNNKKEKKKVLTDSKESINKVPTNSNNSKNKLSTNKKKEINEQTDGKKEIKNKKNILKPEKEDNKKIIYDERSGDFKGFWKKSIPYKDRTFAYDTYDEPHIKRKRIILKKYPQISNLYGYSKKTKYIILISVFLFLCGTYFCTFYIKKWYLFLLFSYIYGGSFSALSGILIHECSHNLAAKSQLENRILGYISNIMLIIPISGSFKKYHLDHHAFLGVKDKDPDLPLDLEIKLVEGNKFMKIFYIIIYPVFYVIRSTFIRKKITKEEIINLGTHIIFILLIFHFMGIKAIGFIACSSWLGYSIHPAAAHLIQEHFTFSDGQETYSYYGSLNKVFLNIGYHNEHHDFMAIPWDKLPQVNQIANEYYSRFNRHFSWFSILYRFVVEDVYGPQSRVARPLDIHMAARKYKIRELEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM7</accession>
    <name>A0A4Q9LWM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0892p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000892">
        <property type="protein sequence ID" value="TBU12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0892p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="49680" checksum="69141E207A761813" modified="2019-07-31" version="1">MDKNTKDNEKEKKLKPKNQSESLVENKNTIIFNKDNTEIILDKEKGLHKDGHKKQYNDISDTFETTELIPNNKVNTNYNQSANVPEASDLLCKEKLILNNKPFDNLSDNLEANIFQNRYKNKYKILFDIENIKKILFLENDKYFFCNDYTVFYKIDQNLMKYEFVNKIFTIYFDNKNIFVITETCKIIVFNVEEERVLCIESGIGKKLHLSKRFDRKIYFVFDDGTLYSVTFDDIKMVKIQFENRKIQNNTFYLDSRNGENDSSDSTDKSDISFEYELESDNSILGKNIFVKNVFVNNNIYISDLFGNVYILENEITFLYSHFSDVQCMKGNDKILLTYSENFLVSIYDIENNKIMYKNKFDVPIFIINLEYYVKEYTICNFSDQEIQKDLPKYNFIKFNKNYFCIVTKENVLVTGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ2</accession>
    <name>A0A4Q9LWQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0641p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000641">
        <property type="protein sequence ID" value="TBU12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0641p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="564" mass="65620" checksum="BE37578E31098CD5" modified="2019-07-31" version="1">MGNFDDILQMFVGNTSMVSRLIEITFGVLNEENSKNYFLNFFSQKNLKEYDRSYKKVCERIEIELPLEKMWKLPIMRKMQNSGLTPYISHNTSLPSSVEVSACEPSYNINTPANSISIDIRFPNSYLEGMVSNCLFAVQTRFERIPERAIQSFPGNITRNSVALDNLLNKINETSGKEIRKAAVDSKVLNLINQDAIIDDAYIMQAAQVCYDEAIRKEKHRSAWKRNIESFCLNEIVFECVREKRLRCTKLRNNSEERIIFFSFSEHVVSRDEIVCFWSTSRNNNDQTSYAIGLKIYKEEPVTNDTCFDPHEYLDFIENTRCNRTRSLFDKNMRACANFRIEHMLRQLLDCLEKTAIPKLENPNKTHLAPIKIFYKIKYSIRDSSRIEMYFGADDVILHCAKSVVRHINLLLLKNINLFLQNKLKPLRIKTNVKIRNNRTEIFILDKKKNITLFEVGIDSQNSLQIAEPEKLRNYDFLANELGLIYRFSFEIIPYVVTCGGINTNNHEKRGIPSVNRLESGQNSDESWERALLRVPRSNNDKYGVKHLKTKNITPLISEEETDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR8</accession>
    <name>A0A4Q9LWR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0252p0030</name>
        <name evidence="2" type="ORF">CWI38_0502p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000502">
        <property type="protein sequence ID" value="TBU13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000252">
        <property type="protein sequence ID" value="TBU18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0252p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0502p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="154" mass="17277" checksum="A19B095F6A9C0328" modified="2019-07-31" version="1">MNNHLIDAPPTYEQVFRENAAHNEDNGSITSGSTISDSNASVSTINIIITKPAKLDFMVVTCMEWKNYNLSKILIFSLLISWIELINQYHFQIDSITNSVLGIHLILCGVFIMAVLKRSKEGISYLKIVLVVLTYIGLFITVNTLSNMLKNPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX0</accession>
    <name>A0A4Q9LWX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0609p0030</name>
        <name evidence="1" type="ORF">CWI38_0766p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000766">
        <property type="protein sequence ID" value="TBU12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000609">
        <property type="protein sequence ID" value="TBU12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0609p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0766p0040"/>
    <dbReference type="OrthoDB" id="2199193at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18647" checksum="B09D8F46C4287A46" modified="2019-07-31" version="1">MYGTDKYIGSLGRTVPKLVNKMDADFYEIDRVGNSLLEVTLEAVELDKVFDIEGNNKRLIYYPLHGYNNQQFQLFLDYSGAYRIMSNGLCMEYNELELAFMRETCRNDRNQLFDIETPAEYYDSDSRNSHFGKPFFAPPTPVERLLNEYGKYNPFRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX79</accession>
    <name>A0A4Q9LX79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0570p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000570">
        <property type="protein sequence ID" value="TBU12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX79"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0570p0030"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="509" mass="58781" checksum="4A7D267569AD9757" modified="2019-07-31" version="1">MAREKLYHLKSEHTESFSTPKTPSKKQAFRHHSISIPSFQLNRNVQPLDVPELTSSDINEHTSNSTTPFYTPHRFSKQKNCQILYFNGSLNFLNLQINSIEEKFIFHKKIGEGDFSEVFCVQTIFDSSVMTPSTDPSSFTKKYCKRKNSEEPLKVEPLKINAKICKKNDFSFLDDNPFICSKSVPRKNKTRYNRENNNRKIKGVKYMDSSFIDSSVVLGVNNGESFSNENLKNNLNFSCIKKYLRKYSGETDRLAKLMEVKILYELLYCENIISIISAYEVDSTLFIETEYCNLGSLRDFINYVYCDKKSNFVAEIVHKIMIEVGSALKFMHGLSIVHGDLKPENIFLKGNLNSFLEQEITDLNENGIFDFQEEKENFFTKMNTELFSDKYIFKVGDFNISKYEDSSVEEDGDKKYMAPETLDGIGVCSSDIYSFGLIYLEILRGIVLPDGGITWSRLRNNNFYGLKLAGLSGWERRMVVQMIDKEYKVRPSAEEIVKIFDEHKNVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX88</accession>
    <name>A0A4Q9LX88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0446p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000446">
        <property type="protein sequence ID" value="TBU13393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0446p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16246" checksum="35966354309E4847" modified="2019-07-31" version="1">MEDQIKITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNTKNILPLILDDVTRLEEPTIDINDKSDLEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC9</accession>
    <name>A0A4Q9LXC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0431p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000431">
        <property type="protein sequence ID" value="TBU13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0431p0030"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="562" mass="64805" checksum="DF2114EBC8195521" modified="2019-07-31" version="1">MLLYETLNIPKKASQSQIHSSYKRLAKKYHPDIYKKDTSPFIKINYAYSILKNKKKRSLYNIYGTSILKYLNNPNTFDLLYLILKKRNIIIYVSSISLIFLNILFLPFLFIFIYLYNIRYLYIFIPIIIGIGILFIPYIEITSVGGGSGYSGSGYGSGYTSNTSDNKDNRYDNNRYTRYTSDTSNKDNTSNIDDNYFTDTSYTTHTNPNTTNTTHTTHTNTHTTHNTTHTNTLAYLTPLHLLFSYSLLFITYVLYLDNYISGWLCFMVLLVKEVYFITTGIINREGRDVDSEGRDVDVDVDSEGRDSRYSSSSGYRDSRYSSSNHYTSNHYTSNPYTSNNHTSNNHTSNNHTSNNTNNNNNNNTNTITIPIVTSFARLVLFVCIISPYTYIWFKCLTPFIYILLLYILRKIYLLVLIGCYSVMSLYFISLGFVLYEKYVWYGFIPVGVIYVVVGIGVSITVKYIMCSRDGCKGGGRGRDRGRDGCEDSSSNSNSNRDGVKVCMLRIEYKDNREYREYKDNKEYKDTKDIKDNRDIKDNRDIKDIKDINIKVVTVVVTVVVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD4</accession>
    <name>A0A4Q9LXD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0544p0020</name>
        <name evidence="7" type="ORF">CWI38_0790p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000544">
        <property type="protein sequence ID" value="TBU02146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000790">
        <property type="protein sequence ID" value="TBU12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0544p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0790p0040"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000532">
        <property type="entry name" value="50S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU02146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="123" mass="13889" checksum="DE6CA22404636DC4" modified="2019-07-31" version="1">MSKNVLKNEIFDTSKKIYTKKNNKKFYKRVVPRSVDAPASEIIRYGLNNENAAKSMEKNNTMIFICDNRATKPQIKKAVEELYGTSVSKVRTLNTIQGAKKAYVRMVEPGEALRVASKAGIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH7</accession>
    <name>A0A4Q9LXH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0415p0010</name>
        <name evidence="1" type="ORF">CWI38_0437p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000437">
        <property type="protein sequence ID" value="TBU13416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000415">
        <property type="protein sequence ID" value="TBU13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0415p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0437p0050"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17105" checksum="159B8231E8564527" modified="2019-07-31" version="1" fragment="single">LIYKCSVEIIPFVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTIETIYFDRRKGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNKEDDVKTENTKNILPLILDGITTAKEPITNTNEELEFEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX0</accession>
    <name>A0A4Q9LXX0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0369p0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000369">
        <property type="protein sequence ID" value="TBU13658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0369p0010"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020577349" description="Aminopeptidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="245"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="542"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU13658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="870" mass="101463" checksum="F39A05A085DB7655" modified="2019-07-31" version="1">MKNYLILIFIFLTKERALMERKVLPDTVYPINYDLHITTEPDTLTYTGWESIDVQITQPTNQLFINSCDIEIVYAKVFINNNFIDALIEYDVKEEKAILKFPQTIEPSIIKLEISFTGTLKTNMNGFYVSNYTIKDKKSILLSTHFEPTAARQAFPCFDQPDMKATFNIKITHSKELTCISNMSVKTEEINENFKTVIFNQTPKMSTYLVAFAIGNLEFIETESKNGVKIRVYIPKGYNIESGRFSLNVCSECLTFFESYFSIKYPMDKLDMLAVPEFSMGAMENWGLITYRMSSLLYDENNSAIQTKKRVAETVCHELAHQWFGNLVTMKWWNDLWLNEGFATWAAALGVSNLSRELIDWDVWTSFISEDVEAGMSYDSLQSTHAVEVPVYDPNDINQIFDGISYSKGASLIRMLENYVGQENFRNGLKEYLNKFQYRNAITDDLWLSLSNNVEGVSEVKKLMDQWTAKEGFPYISVEMVDENHLSLKQERFYLNNVNIKEKNQSHWFIPVRIGFQNEENILVEMKNKKEILVESDFKKYFKVNYGAYGFYRVLYKGDLLYKIQGMLEEKMLEPRDRLNIINDFFSLTMANYFQINDFLLFVRYFKDEENYEVLSSILGGLNELKSIFYKNEIKKEFFRNKILELVSRRAIKIDLAKPGTSLNEISLNALLISSSVGNEDSNILKKFVEIFPKFKKDRSLVSPVFRTSMFNSLMKMKPKEFYEEIFDIYTTSTVIDEKLMALSSLGSSSDINYFLTFLSESMKNKVNLQDKIYVYFSCIANLKYRDSVIKFVMENFDGILQMFEGNTSMVSYVVERVFGILSEESELKELGNFFSKRDLKGYERSFMKVMERIEIRSTFRKNVENINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY02</accession>
    <name>A0A4Q9LY02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YL1 nuclear domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_2543p0010</name>
        <name evidence="8" type="ORF">CWI38_0380p0020</name>
        <name evidence="7" type="ORF">CWI38_1780p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002543">
        <property type="protein sequence ID" value="TBT97043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001780">
        <property type="protein sequence ID" value="TBU10410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000380">
        <property type="protein sequence ID" value="TBU13614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY02"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2543p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0380p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1780p0010"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT97043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="111" mass="13230" checksum="BBFA63FED0A2992C" modified="2019-07-31" version="1">MSHKKLLPFKNYKKSKIGKNIKYRGSKHLLKQLQEEGAEYLFMINQITNKPLKKICDITGLPSNYTCPRTNLNYYNGEVYEYIRNIRPEIVQQYLDIKNSGKEMKMFKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB8</accession>
    <name>A0A4Q9LYB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0323p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="352" mass="42061" checksum="1D36296EC367E64F" modified="2019-07-31" version="1">MIFNQIRANIYFFILYILLQFLTIQTEIIVRFHLKNDSIKKVEESDRKFIEKKSFLNFCSKFLTVKKESVVKNVKIVKILISDLILLNCKEIEFHKKNDGLEIDIDLSKIYYSEFTAFHLYLKSCYFPNNIISFEEFVGFLVVLDELKVDFDAGFIKLIDTILFNLYNLFESSKYYLKESDITDSMKHYNISFSILNFIFGRFIEKYFDCSDFYNLFYNRNDINEENKELGKYVKLFLEIDDKYVIISESFMKKIIKESLVKSPGFFLLQMIIVLSETNTVIIYETNVENLKNTISLFRKKPSKIIFQRFLFNPATMIFLNEYVFEENLISIIFLDYEVINNQIKFSEKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC9</accession>
    <name>A0A4Q9LYC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0472p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000472">
        <property type="protein sequence ID" value="TBU13307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0472p0010"/>
    <dbReference type="OrthoDB" id="1938625at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="556" mass="64346" checksum="5791BCBC93C31E06" modified="2019-07-31" version="1">MSKKIDRGILKGNGLSPLLFVLCMDPFSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIVLKINNEKSATNDPCCEDTATLLEGISVYKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRINARNLFQAFNQHAISLLNYHILDVAVRAVLVKNKIHLRPGCKERLYLSRKELGRGLHSVEFKSEYMLLQLLDCLEKHKDTSTRRAAIPKVVNNNKTHLSLIKNFLKIKYGLEEEVTIKKLEEAQHANLYNEIKNRKLHSKLYSARNNEPVSVNDSSRWLKKGSVRPRDEVLFCYIQDRNVLKTVDHLATRLVRCIHLLLLNKYKFKSSKRIRSHSVQEIFDNEYAEIRGDTRIKTDVKIRCNRSDIFILDKRQNRITHIVLRKYDLLANESGLIYKCNVKIIPYVMTWDGIVTKYHKTYVKRLQIPMNTVETISFDRRRRLESGLNAELSWERVSLSVILGAEMNEEPIPPLKEAKREEDGVKILKPKNKAPLISQGGTTSDEPTNNINEESDLEKETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM8</accession>
    <name>A0A4Q9LYM8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0596p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000596">
        <property type="protein sequence ID" value="TBU12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0596p0020"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000007">
        <property type="entry name" value="Inorganic pyrophosphatase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="284" mass="32512" checksum="10D1E17C54DC98CB" modified="2019-07-31" version="1">MRKYTTKQTGKKYTTDYKLYITDEKGIISPFHDIPLFNGNGNGIVSVINEIPRFENGKFEISKEEKMNPIKQDIKKNKLRFVANVFPFKGYPWNYGALPQTWENPDTCDPLAGLNGDNDPIDVIEIGKIQKKIGEVYSAKVLGCLGLLDEGECDWKIIVIDINDENASKINDIDEIDNYYPGLLEATTRWFRYYKVPDNKPENLFAFGGKFLNKDIAFGVIKEAHENWNKLINTEIGKDISKTNRSLIANQYILNEDFKVEGNISLEEGEVTSSVYEFFYVSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN5</accession>
    <name>A0A4Q9LYN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0594p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000594">
        <property type="protein sequence ID" value="TBU12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0594p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8836" checksum="63AB013C01A8AC47" modified="2019-07-31" version="1">MNAEEYIQSIVLKKTTKERCKSPSMYVIERLEMHRDTKPPSNQVINRTMAPKININEESDLEEETLMVKELEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW9</accession>
    <name>A0A4Q9LYW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0260p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000260">
        <property type="protein sequence ID" value="TBU17978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0260p0020"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="283" mass="31991" checksum="BB1FB339C7B7A14C" modified="2019-07-31" version="1">MPKIVSCKNRQEKGILIEYLTTGHNPAEYSKEERGAVFGFETALIKQIIQTEHAVAHIGEYIKECEACSRFDSLKTIQPVYINHITKKYDLFMMDCVDLRRDSDQNDQYSWILDLINKTAELVRDSLEFLFDNFGVLGAIHSNKTKGARPSGTCKSNHKKIASKKITKDVIYVYNRTMHSATNKSPFMLFFGQPGFNNPLSGSVIVQNEVSTMVPAIDIDPSIVLVEENAADTQWNLEIASDIHEEFTPTVTTTTIIIDDDLGCDKNICSDVAKLLKNYRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC7</accession>
    <name>A0A4Q9LZC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0526p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000526">
        <property type="protein sequence ID" value="TBU13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0526p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020443275" evidence="2">
        <location>
            <begin position="16"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="593" mass="70786" checksum="2133ED011DE77B38" modified="2019-07-31" version="1">MNFFIFICKIIYASGFEYTAISEDSLSIGDNYLEISYEIGADDQVKKCFDKLELNIKDERKEEMVKITSFYYKKIQEYTNNESDTFLAYFTTWICYFVYHPDNKIDMQKYRPELLFNLITFGRFFEFCKNDESIKLIIKDISVKLITYRLENECVDHDVWFKKAYNISVKLITYRLQNECVDPDVWFKKAYDILNAKYPFICSNIENSLNRDNKIDISMLENLKLRTKFFFKSVYNELGIFLANATLENYFSFFLILKYLFLSGKKNTSTSTIEKYSTDDRQLLNFLRSDAESIDKFPRKMNFNSYKKIAENISEPIFRKVLTVKDGFEKIYEFSGKKIQSTAKPEDSNVSLEFIENIVKRKEINYINALYVFLKNISKTEYHEYISEVLFSKAFCFKEIVTSKEKKLRSILEILFIADVLKIEFEKVNKDPSIINTYMVPFIPYIKTYLDQNDIKYDKNLAQSTFNRFLLPKTYRILKNFIFVKLFTNSSWKNKYNQLLKEYLKNKGYKFNEELVVNQNNIFIYVFKQEFSKLSPEERKKIFTIPVIQTPTSDNKTDSQKFGIRRLLLLILVTIVFIFGVIFGAYWFIYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT6</accession>
    <name>A0A4Q9LZT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0481p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000481">
        <property type="protein sequence ID" value="TBU13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0481p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21297" checksum="5C4B4B1663F90CD5" modified="2019-07-31" version="1">MMALIVQKYYGITNTYIKEYVKDREACSGFNSLKTIQPIYINHITKKYALFMMDLAIQSDNVREFKNAPLETFLSESYQAQCQVESNSTIKRWLATKPHETRRIRLIKALKNVFYAHNKTDKNETGAIVPIIQLNSGMVIFKKLAENTQWSPEIASYMYQDFNEPIALKILQYLRISKAIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M057</accession>
    <name>A0A4Q9M057_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0255p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000255">
        <property type="protein sequence ID" value="TBU18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M057"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0255p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15491" checksum="4AA16929CED304C9" modified="2019-07-31" version="1">MTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEKIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H5</accession>
    <name>A0A4Q9M0H5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0131p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000131">
        <property type="protein sequence ID" value="TBU20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0131p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021001876" evidence="1">
        <location>
            <begin position="19"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="775" mass="92785" checksum="3E80E53EF8E76926" modified="2019-07-31" version="1">MLSISLLITTYILTSSLTSVTFYIINEENRVKNLINTDITIDMMFLDENIEYLDKNNEITIFKNNILRHESKFDITSYYIPHTLTLPYSHGMFLNSALLKALFDSREKNIRVFINDVFYDNFLLFLKLLDNFDALINQINIRAFIDILTIITMLEIKKSKQRKEFIKDLLRSLLYGINIFHFDFKRDYYNVVYNHIKRSILRDLIVFFMEFIYFDEKITKSYIVITDCNEVSFKKDSCSLYENCMKKIQKNKIYLRLNDHNVKKLSKFMVSYNLKNTWIFLFKIIRIDLVYFVFDLEESFEIIFKLLFGVKFYTEKFYFHSFKNATIILLKIRYHLFLKNLNVLKFNFNFNLNELKQILSLYDNVNKITIKTHEIDFGTLKFLISYCRDNSYKSFKVVSFCYISENTISNSLKFFPKNLIFLSDLIKNENILKPFSSHYMPFIYNAFYYITQNKLNFLYNILFLEILNAREIQIHLNNYYKTIILDDSIFNSLRYCKTLKKFCIKNIKLSNELLMYILESNTLLFVEIIDFEYAFNDEFFTKSSVLNFNLKFFGFTNSKSFIKSKFMIYLAKFRSVSNLKIYNTGMMLENLYPRFSKHNFKFVKKNISKKIFLKKLEIIAWTSLLYMKNCLFFLSEAYDLVELESISLNPCELTEIDYVLFCKMIKLKVVKIESFGKINNIDLKKLFSNSALFNTVIVMNISVREITSDDIRILSSFKNLMSLSISSEKIDFMTIKNIKRKYFLTTEFILKEPNRENRSNEINEHLDSEFMFSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z4</accession>
    <name>A0A4Q9M0Z4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0087p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Z4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0010"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="30366" checksum="F175DA8C3E6F421E" modified="2019-07-31" version="1">MSTTFTENILSMDADAQEHRMLATTAEKLIKIYTIDKDQINPEFELKGHDGPVTSAKFINKGELIASCCFTGKVIIWKLEGNSYNKKFERKIFEGSLNSLSVKNIENGFIVFCACSDGNVRTLQFDFSLNYSEDLFFAHRFGVTCIDNNDLYVVTGGLDSNVTLWDLKEKKEIETFSDHKKFVRAVAVCPANEFNILTFASCAEDGSLVIYSREDDCIVKQIIEMGSPCYSVSWSASGFSLCVGYGDSFFKTFVPDVSGKFKEVEIVSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z9</accession>
    <name>A0A4Q9M0Z9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0216p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000216">
        <property type="protein sequence ID" value="TBU19279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0216p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="9603" checksum="D2B73CBB12B3CCB7" modified="2019-07-31" version="1">MALRLESELNAEESWKRASMGVIIRAEMLEEPTFSLKEAKRDKDGVKILKTKNNTPLISQGGITLEEPTINITEESDLGEETTVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M130</accession>
    <name>A0A4Q9M130_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0079p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000079">
        <property type="protein sequence ID" value="TBU20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0079p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14128" checksum="7423E95A4172A096" modified="2019-07-31" version="1">MNKYLDILFEELYIIFGNFSFLASKHCIELINFVSEIKECNSVLKTKPILLFKEPIQKIYSPYLPSCKLFNENISIYIPIFTNHRCQTLIETIITVKSPKKMNVSLQSLIYKINIENSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M133</accession>
    <name>A0A4Q9M133_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0345p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000345">
        <property type="protein sequence ID" value="TBU13755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M133"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0345p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17785" checksum="765AAF2D77D8A7FC" modified="2019-07-31" version="1">MSLENNSFVIFIGQINNKEIPYNVKIEQTNLEISFDVKSKILQINNNIALFNYDKNIIMVNAFEFNEDISDKIIKYLEAYDNTPEISIFYSFSELDFVIKLFECFKDYYGICNLISVLEYSEYDTVSSKEQFSKVKTSLNDFVKDFVFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G3</accession>
    <name>A0A4Q9M1G3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0197p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000197">
        <property type="protein sequence ID" value="TBU19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0197p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="774" mass="91505" checksum="15F8942A657123A4" modified="2019-07-31" version="1">MIQDMVLKVKHRILYKNLKMLVLSLAIKRIFTNETIAIHFYKDYESNFTDDDLNSCIYKYKCLEFLPEHAIETKSNINIVYLKTFIIDRSIFFLEFLTEENVQDGKHNNIHINVNDLNYDDFSYFYNLVISFPCFVDYMNEYKYRLIFRIIDIFKIQYNKPLKDFIRLILASVVLNTEVIKLWYFSVLKSNKHIVSIALSNIAFVELLGLYGISKAILNQIKAVYKAVITTECNNFGFADLNENFFYLDTCILQKILKIHKQAKYFLKTLNIFFSLHVYKRFFLFIMSYTEEYKCFFNLSLFKNLEELFMFKCLNTKVFIANIIKTMHLQSIKILTVFKSNLISEDEIVWLKELNFEELNYIVTKYDSKTYFSISEFKSPVCIIFSKIIDAIFNNENKSSFYARGTNISCYDQDNEFVFVFYQDENRVKDLMNHGIACQISFRIKLCNMFINVIFDIINFKRLRNIEIEFTYTCIRDFSIYSSEILNNIVTMRIVGSTVNDVFLSKILLFPALKNIVFYVCTIIFLNNNIILSENTNIEYLNIADSLINNVNYFIDLMNKMVGLKSLEIFNMTKNSNPLEKNSDNIKLCLLKLTYLRYSSSYYSYNNALFFPFLPSLLKFNLGSNHPAGTLHKIFFNGNFYMLRKLVFYGIKIGQEDELALQKLTNLHSLTIGKNSEFSNINFSQMFHTAYTYSLTELILPNIEITYFDLKFISELKNLKKLYIYSFILRTNIIFFLKIISSITEIEIEKIFVLKNHIIEECGIRLKISAWHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K6</accession>
    <name>A0A4Q9M1K6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0290p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000290">
        <property type="protein sequence ID" value="TBU17012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0290p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6611" checksum="39E75EF280611B89" modified="2019-07-31" version="1">MLLQKSIALKICFGTEIKDFNGSETKEGEILRDRSSDQFVTKVEDSVKKVFTTENIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P4</accession>
    <name>A0A4Q9M1P4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0049p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="47827" checksum="14EFAAF1718027FE" modified="2019-07-31" version="1">MYFQGFVYTENLSSNKLRDKSKSILDLPKDEQRGIYCSRNSASSSSDISTHGKTVHDALEPLYVNFFLEEMPILLQNQGISELENILKSEALVDDKYFSVFSTLNDIKEKYIEFSQGKIQECERIFSKILQDINILVKKSNILSKVPSLVYLIKYVNQFILTDIIYTSDKSHIRVLFALKLVKGIITKSEYEIERNLNSFTSTNPNNIDFDIEMKQIYENIFFKEDNSYLLDIMFRFDESDINEIYTLLQEDKNNGTGTSNFHKHLKSRSRKLSDHFISKIICYYFQSFDAKYGERFYALAQGYHTNKPIENDSFHGIVNDTYDIFTLDKSKEKLTLNEVGTLYKLQLIYKCGVNNISYVMTWDGFITKNNQSYIKILRRPYECKRIHSEKSSKQINAEDGCLELRFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W7</accession>
    <name>A0A4Q9M1W7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0028p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53731" checksum="019737952E6A140D" modified="2019-07-31" version="1">MTGEAKAFLEVIGLEINKEKSATNDMCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRSGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDSAILKVENDNKTYLALIKDFLQVKYGMAEELYNARKNELVCVSDSSRWLKRGNIRLRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLEMITLDGIMKSHSVQEILDNEYAEIRVDSRIKTDIKIRNNRPDIFILDKKKNKITLIEAGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYGMTWDGIVTKYHKSRLKRLEIPMNKTVETISFDRRRGLEELTESVIGFIMRAEMHEEPTSPLKEEKREEDGAKNFKPKNKAPFISQGGTTFEGPTNNINKESDLQEETKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W8</accession>
    <name>A0A4Q9M1W8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0035p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="797" mass="95300" checksum="9237575AFA92CFD3" modified="2019-07-31" version="1">MSVNAYFTIKNLTYIYTRNQHIVILLMKLLCGLSLATVSFFVINDENYITNLFDSEINLEMIFAENKSVIWINEEEKITIFKNNILRYEEPFKQPKYYNPNIHTLHHWNSMLFNSKLIKKHLDSKSTNIKIFLKDISYISLLLFLKLIDNSDSFISQINIQDFLDILLIITILDIEKTKERDYFLRDLLRNIMFGVNISDLAFVLEKYYDSYHYRHIRKSIFMGLWINFIGFVTFKDKRAQIFIFLSGKRSFSSRNYKSITDNKIALKKTAKNKLYIRLNDIYTKKISKIIDLSYLMNIWVFLLKITNLDILFLIYFKIETYKNFTRLFSNYMFRTENLYIRSFDLALDFFLKSVNVFSNKLKVFKFEGTLNSLELKKLLGICTNVKNITLKIRILDSEKLRLLIDFCLNNPNVFCKFLCYSYEVLHADIEIIHQIPNNFMFYAMKCQNESPSPHLLAKIIPFFNLYHHSYIHSEFVELSKNFGLFKCFKYKFIEFHFEQNSRPYEFKKKDLKLLRCFDAIKYLFFANVSVDNEFFMYVLESKTIACFQLTNFICEYDSKYFESYATNNQELRNFVVSDSKSYISSTFLVYLTKFECVSCFTLKNIQLKFEALYCSRFYRFFQSRVGNNQNKIYLKYLEIRAATDNTDCVNYLHFLSNIYDFSKILNIIYFVHELREIEFAFFSTMTKLEAITVKVYAKYFQIDWKNLFLSRELFNTILVIDISTHVIRIDDINVFKLFKNLKVLSLSCEVLDFDTIHTIKKTDFKNTNLKIKKPSRANRTAEINNYLDSEFNTNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y4</accession>
    <name>A0A4Q9M1Y4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0245p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000245">
        <property type="protein sequence ID" value="TBU18339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0245p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24520" checksum="F6A14611C63A398C" modified="2019-07-31" version="1">MNNFSQKYLILVLNGLSFLFFLATVGVVFYAVNFKNMSISSFFFGRFERNMKYFVDLNEKEIKKKVFDGKKVLLTVDDTVNIGEYKMFKSRFSPKFPTVIILEKNVFIFPLKKSIKVMSVLEYKDIVIKNIEHKISLLSYWNSDKGVLSSILNNFKRFIETSHPINKYIPKIIFTRYDSTDETLYLSMDACYKLRAKSENEILNFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M229</accession>
    <name>A0A4Q9M229_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit of RNA polymerase III transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0021p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M229"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M229"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0060"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="1">
        <location>
            <begin position="155"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="41236" checksum="0C5EACF632B93FDB" modified="2019-07-31" version="1">MSNFAREESFDIIEWPFNISENFDNQIIKIKDGYEIRIIQKIDSKKVLATKKISKTTYFHVRIDKNLSIISHTKELYECVTPIDFYIPIESAALSFYSDLYQNLIYEEDEKVLEFSKEFNKKYINKEISVPVYMPPIVSMPGICGNYNFKDTSYKKTKRKIAIQIKPKEKVPISYTKEIYDELSKYGNLFEKAVKYLNKFVENHNIFRTKDVCNDILQNKCTDLSQDSIRRFFPMVAYLYYSGPWSFIWVKYGYDPTLYPECYKFQDIYCTLNYKKVAVIDRPEIFEEIEKNKNKYLNSVYDEKHGFFNEKCIKYLKKQLHQRFFLPSGISLDLKNEDLEFDTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M243</accession>
    <name>A0A4Q9M243_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0234p0060</name>
        <name evidence="11" type="ORF">CWI38_1468p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001468">
        <property type="protein sequence ID" value="TBU10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000234">
        <property type="protein sequence ID" value="TBU18635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M243"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0234p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1468p0010"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU18635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="29414" checksum="70C01E83146A77CA" modified="2019-07-31" version="1">MSENQNQDEQGNNGEGKNWLKIILTIVLVIIGISILGFIIYYLMVKYGSSSSAGGAALAPKSKGSTKEGKESKESSSKDNSSKDNGKDKESALIGEPLKQSAESMAYSSFHPESNIASKEEKSEKKKKGAKSALHEGFDIKNDLFAQKEVYQPGSVSVTKTLLYTFSFSKTPLYNFSVTNTLYIPLTLYLTLLLLTSFYFLFLKCPLKMLYHYLEDNIRKYTLKENNNTIQSHPCKFSPVDELSEYRVVIKKRFKIKPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M287</accession>
    <name>A0A4Q9M287_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0098p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000098">
        <property type="protein sequence ID" value="TBU20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M287"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0098p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="16777" checksum="CC5A68AC3D66AC4E" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISSKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C1</accession>
    <name>A0A4Q9M2C1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1903p0020</name>
        <name evidence="4" type="ORF">CWI38_0194p0050</name>
        <name evidence="3" type="ORF">CWI38_0361p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001903">
        <property type="protein sequence ID" value="TBT98107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000361">
        <property type="protein sequence ID" value="TBU13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000194">
        <property type="protein sequence ID" value="TBU19822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1903p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0194p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0361p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="114" mass="13065" checksum="C663F31CFD1EFBF6" modified="2019-07-31" version="1">MYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D3</accession>
    <name>A0A4Q9M2D3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0009p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2D3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0040"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="4">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="14194" checksum="9BD3FA33F6B53D92" modified="2019-07-31" version="1">MRIRKNRNSDKIVKITEKQPDPLQLIVIKKQYNPPVSLEKKVPIYAPPSIPLSKEQKEYWKLPPCISMWKNPKSRIISLEKRMQHIPKHPSLNINFEKFSRFKEALDEAENDLKKKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E6</accession>
    <name>A0A4Q9M2E6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0014p0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2E6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0140"/>
    <dbReference type="OrthoDB" id="3562449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21153" checksum="D4C2F3E486198CF3" modified="2019-07-31" version="1">MAHENVLMCSFRDKKSNPNPVILISSNSDTNSVTIKKKKGNFEYEKMKPSMIHDYNKYMGGVDECDKMLYVYLDERRTLEYWKKVSYILYVSNTTEKKMNRLKFTSKIIDDIEKEWMYHKNSVSTQPSSSTNKFALEKLPGRNLRQCAVCSNKRSGIKRSHLICACCKKGLHAICAAKHSCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L8</accession>
    <name>A0A4Q9M2L8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0199p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000199">
        <property type="protein sequence ID" value="TBU19801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0199p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="29316" checksum="561830272B542B69" modified="2019-07-31" version="1">MESYKERKKWHENRKYYILLSLYSLLLHLFSFLLLLFIIFFHTSFSNISIDYKKYITIYFLKITPNLILCFFDIFTSSSVLNILLLLLIIFLQTKEITGLLKNASYVYNSNIMNLIRIFVPMNEKYIINILILNLVYNTVFLLLIRIFRSHKHRILFLYLYFSLLLKPLYNNEIYCYIVLFIFRIFLYKIIKIKKHINIYNVLLLIYLTTVTEIVISCLHLCFSLTNIEMLNIRSVSANIFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3C8</accession>
    <name>A0A4Q9M3C8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0136p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3C8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20633" checksum="C0BA60CD7EFDF00D" modified="2019-07-31" version="1">MKKQFVKEMEVQLAKLYNEIEKRKLHSKLYNVRQNELVSFSGSLRWIKNGNIRLREEDQHCNKSAKNLDYLTTRFEEILRYDCLKLHNELIKLETRIKTYGNIQNIRLDIFIWNKRLNGITLVEVGITSQDCFKTYNTLENELNLIYKCSVEIMPYVVTWVSIIIIYHRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M411</accession>
    <name>A0A4Q9M411_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M411"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0200"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="33498" checksum="E37B94BDD78FC19C" modified="2019-07-31" version="1">MSMQDSELTNGFLRSILTITSLEKIEILRCKVCIEKMDTHIKHLNMRSLSIFGSTVENSDELPQFINCKTNLKILTLQYNKTSSVFSNNMQENIIKLDYLKTLDLREEFNSNNYFTNFSGIKTIDTLKIGYGYKEGSIFCLFSENNLASVRVLFLFKFTIGNNDINAMKNCKKIQKLVFTECEFRKTYFYQLFGNYEVYIIEVLELKKISLSMLDCLFISKLRNLKFLNLKIQHINFDSIKWFNSFNLQESNFKLQMIVSKKYWIEIEQFKEMIGTNNFEIILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5H1</accession>
    <name>A0A4Q9M5H1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0054p0070</name>
        <name evidence="2" type="ORF">CWI38_0018p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000054">
        <property type="protein sequence ID" value="TBU05063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5H1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0054p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15319" checksum="82FC81EC61E54F91" modified="2019-07-31" version="1">MPLKNRVQDTQTYISGQYSLIVTESKSYASDIYTDVKLLDRVTPVPSGFNLEFHTNKQNIGIIRNGNLINLSIVKIKPHVEVVDTFVLEYKGGKLIDFTMDEITEKNDTVTILRIRLGNVDSLIADYQDLLLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M615</accession>
    <name>A0A4Q9M615_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0001p0220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M615"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0220"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020340586" evidence="2">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="380" mass="43262" checksum="23DB4F8BCCA4DF23" modified="2019-07-31" version="1">MIVVNFIGSIFLLLDVYKARPSAHYKKDYNHYFGCDSSSVSCASDSSISNSHLDSSDISGITDENSEDCDSKEHKNRSGITSFSRALGKKAYGTLKKLIETKNFKNKGEEARNIALANSINFYFEMISQFLPNNLVDKYINLLNKKYYIDAFFLLNNLYEKNDFGQKFFEDSFSVHNEAKVNGILDFTIGKIPSVRTGISRIKVSTVADMFPKFEGSISQRSHRNHTRDCKVIIVTSDLSTFSFMTSYKCSKLGSLTGEFYVPHFVLSPRLLAQTSAKCDYIVFKYFLRALRILAKIDENSKMITEIDRLFRSLMVSKSSVSVFHSKLLISKMFYDIAFTIPNKNTFKLYLSILKFGSLKHKLESKSPFLAAIITFFDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWN4</accession>
    <name>A0A4V2JWN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2233p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002233">
        <property type="protein sequence ID" value="TBU08662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2233p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7466" checksum="00B734F4003363F4" modified="2019-07-31" version="1" fragment="single">GNIINSFRKSNDVSKLGFARNRFSGSTMRCIIIHVLGVLATFKASRINSWISIHFRIYLAYFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX56</accession>
    <name>A0A4V2JX56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0616p0020</name>
        <name evidence="3" type="ORF">CWI38_1715p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000616">
        <property type="protein sequence ID" value="TBU01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001715">
        <property type="protein sequence ID" value="TBU10502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0616p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1715p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="140" mass="16425" checksum="979CE41CFBFF0C66" modified="2019-07-31" version="1">MKSNQYKIMGLLNIGTSLSSQLKNTEVDTKQPNKELSNESSRGKRNIHKVLAENNKKTILYFIDGVDFGVNSIIEIKKEIIEEEDRIIKQNEYFLIKRTEYCIDYDVIKELLEQNKKKNGNKKTIDTENCEEFIEEPEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP1</accession>
    <name>A0A4V2JXP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0710p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000710">
        <property type="protein sequence ID" value="TBU12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0710p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="31688" checksum="7D491215B898D039" modified="2019-07-31" version="1">MHNSKKRSHIEIASYVHEEFTETVTTTTTIIIDDLEIDFKIRSDIKICDVDVAMLFERLLPQPTIDNNTPFSNTMENLNTDAILEGNRRIPKYAILAVQKGFERMPRNSCVATLRHHNEKIGYKLDIDAQKENIDRRRIATFLTDSCTLTTQKYAMTKQHAKRTLNRSKEKHSNLKKIMQELYSNLSSVSDLSETQVMKNESLNKETIPNRKSYLSKHEVIRDEIVSFWSTMWNNNETVSINDFLLDFVLENHPTMFPSLDEFVNFINLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY1</accession>
    <name>A0A4V2JXY1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0403p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000403">
        <property type="protein sequence ID" value="TBU13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0403p0040"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="408"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="509" mass="58156" checksum="8EA9C9D87BAB871C" modified="2019-07-31" version="1">MGDKQLSRRRKSIKIVEKDRTEQEIDKVPAAKPKEEVKKEIEDTTKNAIGMVEGEQPKESEKEKTDKESAKDEKSKPEEITKPDEKDKKVEDGIKDAKKISETNEEEKDSFEKEKSKIDADKVEEEKDNLDKESKSAKPAEESGKAISQEKEKAEDTINKEKDEKPPKDKDKKVEEDKMMKEKEEMPLKDEDKKEKEDKMKKEDEEKETVKKEESKNKDINKDVKEGTNIISDNKEKKEEMKAHNSSEEMKTDEKEAKDKSEAATAMKLSEPSEEKRDKEEKGAATTPEKKVIISEDKNKEYAVEKDENKAIDASEEEEALAQEGIKKSQESAKDKSKQGKEKRAGYLAGGLLAGGGTTGEKEVKPLVDKKLLEKDSGGEKLDKRPSDPGTQVLDPGSELQKERDDNNVSYEGEVFKRRFFCSCFWHSRHFVLTKTGTLKYYRDLNNKGKGNIPILTIMDMQRLDNMSSRHPYQIILRFADEESVMAFDDKDTRDTWALKLASVRGKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY40</accession>
    <name>A0A4V2JY40_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0231p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000231">
        <property type="protein sequence ID" value="TBU18736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0231p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="24733" checksum="2FD242DFC5142674" modified="2019-07-31" version="1" fragment="single">MLQEDSLSPLLFVSVTVQTDAESYSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEYLEVIGLEINKEKSATNDKCCEDTATLLEGVSIYKYLEIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKKLFSAINQHAISLINYHIGVLRLEPAYFSKLDDAVRAVLVKNKIHLCPRCKERLYSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY72</accession>
    <name>A0A4V2JY72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0164p0010</name>
        <name evidence="2" type="ORF">CWI38_0585p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000585">
        <property type="protein sequence ID" value="TBU12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000164">
        <property type="protein sequence ID" value="TBU19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0164p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0585p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15305" checksum="9013BE85A9226AC8" modified="2019-07-31" version="1">MSDETIKSIKKNSIVKFQNEKILIELDSASENCRKENTSDPWRKLTLCMCIFLCILNFVWCISNWGENNLWIESSTIIGFSLSLYCIFELVFGDITDKLRVILILIFAALVIFLYIITILTTLLIPKNDSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA1</accession>
    <name>A0A4V2JYA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0088p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="27297" checksum="245729ABC8B550C3" modified="2019-07-31" version="1">MCIISKPLQWLLSSSLLLIIALGTLGFLSYRSASKYIENLESDYKKISELDSFRTLAGDLKRERIALLSEMKDDIKFTVFKIKDANDRKNLLDALDKKKNGEVQESSSILISTNTAYIIPIKRPSRLGDINFLTKVGFLLKKKTTMQTISELAAYIGKKPKSSDDANKTVMLFFNIIDEKKVGIFCVESEDGVVKKTNKEQIFIIKHPSKNIKGEISDFIAYIIEKNRKEESKTEKKTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK4</accession>
    <name>A0A4V6MVK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1731p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001731">
        <property type="protein sequence ID" value="TBU10482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1731p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="526" mass="61752" checksum="8D7D4C8DEB8498BE" modified="2019-07-31" version="1">MKESFFVGTIKLIGLLIKCISDMNNSFGSQYMICGMIYGAMKKGAELRKDWQEDLNESVRKAWMQDCLRDSINPSTRLPDKRFCFITTNSMEDFFDFFYIFEPGFRCIKESIFDTIDFITEQNIEEIQKQVKENLMKENIKREVFLNTVLSRFGSLVIEKLKSFLHNKFSQILEENKSNADLFENAFLLIQACGDNTKEGNFSDLLDAIKSRFFLYDSGVILISKFFQFLYVKSKKDIYFNFFRKTNEDCIAIEKEKNLIYKRLKSQRVRIEYDADINNIFVPFSSEDLASQYIKDCLVFCTRTAEISLNSKLGKSNPRFLFTGILTDELKIFRPAFMFSESAIYFGYGFCNKTISDFIEYGGINANLRIFQFSYIDLSFFFPEFLLNYADRLIGSSVPKSLSEIASKEHVCISDQTKELIDHSSFNKSIWTDFLHEIYKVYVKRNNFNSKLYISVFEISLESFKEIYYSFIKELKKNQEMFLVSDQEIEKCREFFLRCILYKIKSITNCFKLTNVPAIDVEIIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN2</accession>
    <name>A0A4V6MVN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0479p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000479">
        <property type="protein sequence ID" value="TBU13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0479p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="406"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1098" mass="126641" checksum="899D96B55BC8837E" modified="2019-07-31" version="1">MGRRKKVDSENIKNEEIKAVNNSEISLKETKTCDRDEHYVICYFSQPARFRPPSSCPDSSAGGPANTMENLNAPAIPEGIRQMLLHSILDSVTAVEQEWPRSAMSAVQKMFEECLEMAGLQFLGIIMGNLVELEKRKEKDGERRRIATCLPEPFSLTDTTLYMNLREKFLFKIKELSEKEIGDVVVRTRKLPSELVDSKVLELINRITSECTEFHVPKNVSDAARIIQAAQVCYDEETRKEKPRSAWKENIESKISKLVLSKDLLEKARKLEKLSTSETKSLRKIMREFNLDLSKINDLTETLVKNNEALNVYEKKITMYESRRKFRKENRMFVLFRARFYPGYLSGLNPSMWFIVYEISEFWSTMWNKNDKVVHMMNAGIDGNYNFYIKKLTSLQKYLYDIVKVIFLELTPQADWYYCGLTYLIPKGTPKTGSDYRPIICMSNLYKLTKKCLSSVIRVEVERRGLLSENQLGAQALHNIALNKGYGNNRKTTWIDVKKASDSIDHANFTQCIENLNLPDWSEKIMNKKIDKGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTIKTDAESHATNHLLFIDDIKLLAEDGQTLEEMTEEVKKFMNNIGLEVNKEKSATNDPCCEDTATLLEGIGVYKYLGIIEDSRGIPTSKSFEGVQTKLIARVERLCRTRLNARNLFQVINQHAISLLNYHIGVLRLGPADFFKLDDAVRAVLVKNKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLKKHKDTSIRRAAILKVENNSKTHLSAIKNLLKIKYGLEEEITKKKKEEAQHANLYNEIKTENYIQSYIALEITSCIRSRDEASFYYIQDRNVFWGAEVMCQHCYQSRKTVDHLATRCEKMLVVRCIHLQLLNKYKFKSSKRIRSHSAGHIYLDKKKNKITLIEVGITSQDSLQIVETEKLRKCDMLANELGLIYKCNVEIILYVMTWDGIVTKKHMTYVKRLQIHMNVEAYIQSIVLKKTFKIISFDRRIGLESGPNAEESWERASLSVILGAEMYKQAIPSLKQEDNEEDDVKTENTKNILPLILDGITTVKEPTLNANEELELEEEIEGVKMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVQ2</accession>
    <name>A0A4Q9KVQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar import and degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0458p0030</name>
        <name evidence="2" type="ORF">CWI37_1515p0020</name>
        <name evidence="4" type="ORF">CWI38_0529p0010</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001515">
        <property type="protein sequence ID" value="TBT98982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000458">
        <property type="protein sequence ID" value="TBU02543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000529">
        <property type="protein sequence ID" value="TBU13107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVQ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KVQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0458p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1515p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0529p0010"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="183" mass="21732" checksum="F758C7DE87DC8A9A" modified="2019-07-31" version="1">MNYLSGIENGAFYEGEQMTPTGPFKIDMKVELIQLRQGFLCGVFRIYNLTKEHDLLITYFEGEIMGTYTNPFLPALTSEAEDDILHWNKFPEWELNYISEPESYDYEANNFLYIKIKERFLLPDPSIKNIPGASIEGLYYCRYSKQKDFFSGFYFYKNYTSNTSQHLKLQRTKKRTAEYYEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWH6</accession>
    <name>A0A4Q9KWH6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1751p0010</name>
        <name evidence="9" type="ORF">CWI38_1126p0020</name>
        <name evidence="8" type="ORF">CWI38_2121p0020</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001751">
        <property type="protein sequence ID" value="TBT98449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002121">
        <property type="protein sequence ID" value="TBU09751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001126">
        <property type="protein sequence ID" value="TBU11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWH6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KWH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1751p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1126p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2121p0020"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000007">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT98449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="143" mass="15600" checksum="8415AF413A7AC599" modified="2019-07-31" version="1">MSKVKGKHELLEKKPRRKCTFGLQVGTWFTCADNTGAKIMKIIGVKGVGGRLNRLPAGSPGDVVMASVKKGKPDLKKKIVMAVIIRQKKEIRRRDGSRVCFEDNAGVIITNKGELKGTQVAGPVPREVCDMWPKISSQASSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7Q2</accession>
    <name>A0A4Q9L7Q2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0308p0010</name>
        <name evidence="11" type="ORF">CWI38_2259p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01000308">
        <property type="protein sequence ID" value="TBU03356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002259">
        <property type="protein sequence ID" value="TBU08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7Q2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7Q2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0308p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2259p0020"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU08467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="334" mass="40057" checksum="2E896186120DD943" modified="2019-07-31" version="1">MGTFILKKDLTAIEKLGIGRFWQNYLVHFCGLNEDKNIFFEMRVMKKKKIIELNEEGCIKEEYKKRFAIRCMFLMNVISTFQDYEYLYYIQELPRGGFFYYYLRSSKKFTKEVSKFYFGEMVLGIQYLHSKGMFFRLLSPDNIMITLDGHIKLRFDFLNSIGMPFSEYEKNIEYIPIDYVRNKEFSIESDYWSLGIILFEMMVGSTPFAAKSYEKVVFKMLNDTINYPSFIDEETKDLLIRLLDKYKFRRIGHNYNDRYLIRTHQFFNGINWISLSQKKIRPPITIKVDPLADKKNGKKVSEMFTTDFKKGQTDGYGPMFRYYGTTIDKKIYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC89</accession>
    <name>A0A4Q9LC89_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spore wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0013p0040</name>
        <name evidence="2" type="ORF">CWI38_0357p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000013">
        <property type="protein sequence ID" value="TBU05428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000357">
        <property type="protein sequence ID" value="TBU13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0013p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0357p0040"/>
    <dbReference type="OrthoDB" id="2187049at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29639" checksum="9A7608B577010051" modified="2019-07-31" version="1">MFLGCIFGKVFIPPEELALPPSLHLYDPLSCTTENKTYTVDLKVHTQDSVVKAIHSIATSQIDPHETEREAIVAYFGTIIDELNNFLIKYKVQLHLNLDSYNTDEFMGNISVDPSCEKSSPVIERTSSAFSYLKDSFNDNIGVHLFVWGCIYISNMAELETVYSNLRCGRVIGVLWKGAGETRTIIKTAIMDALTGIQHSYLSDNEFDAKFAAELCKYVTQCIGMDKSEIGQLVWGTDLVHYTDPVHNHPPADVLDPYDAVMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDB3</accession>
    <name>A0A4Q9LDB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2670p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002670">
        <property type="protein sequence ID" value="TBU05963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2670p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="11030" checksum="06632F199C5C3FFA" modified="2019-07-31" version="1">MSYNHLKEEEDNLSNKDISISLDNLGQKYSGLKPIKKPTISELPLPDICNFISVFEEDETPFIFKGGTTLEEPISNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI40</accession>
    <name>A0A4Q9LI40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2529p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002529">
        <property type="protein sequence ID" value="TBU06660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2529p0010"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="29903" checksum="F2AC5AF9DD725D82" modified="2019-07-31" version="1" fragment="single">ISKMLIDALYYLHSKNILHNDIKMENVWIKGNKILLSGFECLTKQDFKSVGSYKKKSESQEYVASKVIKNNKLYFAADIYSLGKLMKQIFNFKNIKYFGPGKDERVIQMDSIFDGMMDHFPENRDSLETVMGFDIFSVFYSFVFCFCKQKDINFESVNGKFIKKGNTLINIFINRKIIIICSCSEQKPMRTSIRRKMHSMVKNIKVWRKTKIFDKKNITVSINGVSKPIYFLSLDELNDLELIFLRCKKFWNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI80</accession>
    <name>A0A4Q9LI80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2339p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002339">
        <property type="protein sequence ID" value="TBU07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2339p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20330" checksum="7629B0234641FCE3" modified="2019-07-31" version="1" fragment="single">DKRRNKITLIEEGITHQDSLQIVETEKLKKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLTNTSLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIS3</accession>
    <name>A0A4Q9LIS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2335p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002335">
        <property type="protein sequence ID" value="TBU07897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2335p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020943650" evidence="1">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="50094" checksum="4A1E99ECAD31F5B9" modified="2019-07-31" version="1" fragment="single">MKIFGFLTLFLLIYSTVKSNNKKSKETKKIEVIKSRNHIPDIVIYNDKDSSIYKRVFNQLYVERLTIYFSEIFNGYLNERTYTERILPKLKNIASKCEKITDSKQKHEEFFKMVASFARTDIIHCKRLFLVKYKNDKTRNQFFDQLLEFSSNNNFVSQADFYKDIIYSSITKVKTHTTVIDLKKTFEAAIKDNESDEFHIVINLLAQGFSRLIGDLICCFPNFEDLYRFLQDNDQDKLKYEIDLFSNTFIDSFFKSKSKMESFIRLPFRDLNFQVIKNSKYLKNCEFYRKELNFFDICPKKMLEMPLNRFFCLGNNQNIINAWNETDERVNPDSSISCPKKGIFQSDLTNINQIEDADNIEKLKKEFENFIKSFKTNKNKISNQKNTIIYCILNLNNFFEEFVEETTNKINEKINTIKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKE1</accession>
    <name>A0A4Q9LKE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2323p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002323">
        <property type="protein sequence ID" value="TBU07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKE1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2323p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="894" mass="103097" checksum="7CF673C0D5E0D5AB" modified="2019-07-31" version="1" fragment="single">MQYNRNNSRDNESTSQKRKINFDGDEFELGDKQREESKLEQFFNIDPKAVFSNEAMATEFENIRRYALSNDSGGLNNFSFSEFCVDVGSVQKRAEGGCENGSFKSNEDKRFAVADDFILNGNENIKKKECDIYSQRLGMIRPEYFGRPNTPNFSNLSRREQDIVLNARNIHSVKENNFISNGYNAPLPLFQRHPPIYAHEMPYNRNMEMHKYNQQNGSSMHYMHKQKTNINPTVFMHREKFIETPHRGNSVPNEFYNRYRKDIPMNTHPSNFSRFPPLIQNPYQLNPPNIFPPKNLNHKNFPPPPPYPNTPYPQPIRINSPRPPPFIPIQHNNTPITHINPKLITPSTTREITPTPHIYTKTLKSPFNNRTIDLPPKDPSKLRLVNTPLTPTPPTTNSPQPPPPPNFLSTFPPSFIKTLKIRKIFLSKINVPRSLEKINPKDFLFYLHLINSLLSIHMHISPQEQQILCRLFFISITHNGFAFTEKNLYSLFIEITGKQFTYFKELYLFFIYPLEQIFYKLPVIYIAEPLIIDKKGVILQRMKYLFSYFKLTPLNISMGIKYGNSIDLVWILNVIKNTELPKNMFEDVLSVYYEISSYIGSYSKGDNCKGNYRGNCKDNCKGVSDYGLGIDKEKEGVNNTSDKQHPLDISTINLHPVNNTSDNLSPLNDSTNNLHPVNNSSDKEDPVNNKDKEQDPVNKEDKEQDPVNNITNTLHPVSNSTSNKRYKCVKGNKGVNNNDTNNNDTNNNYTNNSDITPYDKGVNNNTLSYHRLHPLSLINLILLREQCLDIIIDSLDIYFNDSLKYLKYFILSPSSLHRFIDSIFIFNKICNNKIKEENKIYRGVINKESGEGVSDKKNRVEGVSDRSMLEGVNNEYDIKGVNTSTSNYKGVNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ32</accession>
    <name>A0A4Q9LQ32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1692p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001692">
        <property type="protein sequence ID" value="TBU10538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1692p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6400" checksum="5E64821AE7C6C3D5" modified="2019-07-31" version="1">MRKEPTPRLKQAISTEDGVSRFKRKNNQSYISNSKTPLEDRMINIYKDSNIKTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ86</accession>
    <name>A0A4Q9LQ86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1935p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001935">
        <property type="protein sequence ID" value="TBU10216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1935p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="205" mass="24717" checksum="D0258855F498F5F6" modified="2019-07-31" version="1">MNSSRCTRTLDYYFIVLNIFFYFEVSICCHNKVESLHSKTSSSSNFDADIFQKSTCYENNINEIQKKYKNDYHYSRPHFRNFFCRMHSNKCIPLTSDLQECSSISRCTIKSEKKHSFKSSDETEKFLNLYQKLDFEKKKYIKCKERIKNIRNTRKKLDLTEKLNIIQLEINEFYYLYKERKPDVINLQRIVDSIESSLIIIENHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE5</accession>
    <name>A0A4Q9LQE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1884p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001884">
        <property type="protein sequence ID" value="TBU10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1884p0020"/>
    <dbReference type="OrthoDB" id="7697409at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="377"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="774" mass="88092" checksum="CCCBAEBE11A00EF3" modified="2019-07-31" version="1" fragment="single">MCYVDLAMLSERQLPLQTLHNTNHQPPSCSCQTSLVCLVDTIPSSSANGMTNLNTDAILKGNRRMVLPSILDSVTVVEQEWPRSAILAVQKRFGRMPRNGWPATLRYYNEKFGCTLDIYAFKKLAQNEAESEIRQEENGERRRIATCLTELCTLIDTTLYINLRDKFLNKIKEISKKEIGKGVFQTRKLPSELDDSKVLDLIIELSMTITAVAQIIQATQLCYDEATRKEKPRSVWKENIESKISNLVLCKDLLAKARKQEKLSTSEIGNITDISEALVKKNDFFEGFYRGLSERVESEHLGSRDEIVITYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKDAGIDGIYNFFIEKLTTLHKYLYDIVKVICLERIHQADWFYCGLTPLIPKGIPQRGFAYRPITCMSNLYKLTTKCVTKVVQIKVEKQGLPAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDFKKAYVIILKWKIDISVGPEKIMSKKIERGILQGDSLSPLLFVLSMDQLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKYSSTLSAMTGEAKEFLEVIGLEINKEKSATNDKCCEDTATLLEGVSVYKYLGIIEDSRRIPTRSSFEKVQSKLISTVEILLIRLEPADFFKLDDAKRAVLVNNKIHLNPGCKERLYLLRTVLGRGLHIVELGNKHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKTVFCYIQDRNVFWGADGVCQRCNKSGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQF1</accession>
    <name>A0A4Q9LQF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1595p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001595">
        <property type="protein sequence ID" value="TBU10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1595p0010"/>
    <dbReference type="OrthoDB" id="7978815at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="393"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="605" mass="69571" checksum="ED96BDE0C8F2B9EA" modified="2019-07-31" version="1" fragment="single">MGRKKNFSSEISNNTKIKAANDADEVKRSDSEIQKCKLHPPAIPLPSSSYTTITHPPPSQTCSKMQNSGLDNFPLPNTHFPLHLKSLPIPEGNRLMAFRTIFDSITADPKEWPRILHRYYDEKFCCSEILEVLKKLAQSEMGKDVKSEENGERRIIATCLTDPYKFFSKIKQILEKEIGKVVVRTRKHPNELVDSKVLDLINRVVGEHAKARVPESITVTAYIMQAAQVCYDEATRKEKPRSSWKENIESKISKLKTIREFNLNLSSVTDLSEALVKKNESVNVYEKKITMHEMNRKFELFRGRFYQWLSVRVESEQVVSRDEIVSFWSTMWNKIYNTVTYDDYLIPFVSDNHPTTFTLLDEFVHIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIFYCGLTHLILKGIPRRGSDYRPITCMSNLYKLTTKVVTKVVQLEVERRGLISKNQLGAVRGVRGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKKIDRGILQGDSLSPLLFVLCMDPLSRNLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT7</accession>
    <name>A0A4Q9LQT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1517p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001517">
        <property type="protein sequence ID" value="TBU10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1517p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15458" checksum="2E5A69625E590F8E" modified="2019-07-31" version="1">MTWDGIETKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNSEESWERASMGVIMRAEMHEEPTPPLKEGKREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETAVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQY7</accession>
    <name>A0A4Q9LQY7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2071p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002071">
        <property type="protein sequence ID" value="TBU10031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2071p0010"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="1">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="49956" checksum="00A9828DAEC9E5DA" modified="2019-07-31" version="1">MEIKEGREGNRILPVIFKLATTNNSSKGFYTKNWCKKIEYERLKSLEKGKNILKNYSEKTSDYSRKINSGIVEIIRESKKTYSDYFLTKNEIKSISISKIIFDLRKSSYNLKILVTMAKGTVKLYFLKIESLENEIIGLIRCTFLNEKNKLLYKKKSKNNIFVIKNCKNEKMNTRKANILEDNIYIDDDFVPDDENLFSNSDPEMQLKDSYSNYGDHTVECSDIHSNNTNFQNNITDSIAQNTILENESKFLSKIEKQFIIDENIEMPFFPLIFCPKKVKVCKDSILFQKKIKENTPVFIKLKELIKNKEIISDQEHNLNNNICEGWEGIEAEFENFNVSNEYDSIENIRLASSISLNPDESSCFLFENKFNLNEKIVFSELVAGYSKRNAYEYFFKLLFLAQKDVVSLKQKYDGEIYIIRNPGGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR11</accession>
    <name>A0A4Q9LR11_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2086p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002086">
        <property type="protein sequence ID" value="TBU09945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR11"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2086p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="8">
        <location>
            <begin position="500"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU09945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="563" mass="64803" checksum="383340DD14808C11" modified="2019-07-31" version="1">MKVEETDKYLKEFKDVLLTVSEDYTKRIDNIIKKYVNVNIDSGLENEKNVKKNKNNFIFKENENNKKVKTIGKGDITNGCGKVKTIGRVNRNIENTGNNNSRLNTNNNNRVNNSRLDTNTNNRVNKMDNSRLNKIENKMDNSRVNKMDNSRLDANNTNNNSRLSTNNNSRLSTNNPNNNKVNKRLNNTDNNKVNNPDNKMNNTSNNPSSIKENNFDKNLISKSVKKEFIGGGIRDVNKKEKRSVEKVQKIKLNIKTPLKRGSLIDEGVNVDFKENKSSFSILHENIKDFVEEKVIKEDISSECQLDMMTSNNSLNFNENKFDLEKNVKNKLQIENSLMYKNEEEDNSGLTIFDLKNGDLKFDLSDSIVKVNEELDNLLAQFKNEIEDDRVLNVERCEDDKNLVVESTESKGFENQNVFMTNGSKTKNTIEKSSNTTFFSSGSPDSKDSSLIFYKRTPVDSLYKSVIDKQIRNSSAFRNSIRFDLNSYKPKTVVPVVKLNDEEDLLDNFKLPEWAKDTNLNGIVKQQSHIDLEKYFYYLEDLDVKKIFPYCSTATNESPNKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC4</accession>
    <name>A0A4Q9LRC4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="9" type="ORF">CWI37_0043p0070</name>
        <name evidence="10" type="ORF">CWI38_1414p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000043">
        <property type="protein sequence ID" value="TBU05162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001414">
        <property type="protein sequence ID" value="TBU11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0043p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1414p0030"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="184" mass="22053" checksum="AA794E1601BDA394" modified="2019-07-31" version="1">MDSNEHISFRDNYWLNTNTLTPETVLTYFSNSQFYDKSCNNEILKMQTQYNNLIDLKLKLNEMKGIQYIVDHTDTNNTLFVIQKIKRYSSNDIELLNIYYIIHGNIYQSPTNIGIFKSRMCNMFFYLSEALDMYLDRRVYNPFKGSSIGKINTLEIHESEIEEENEEVKFLYKIFNDFKNIEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD1</accession>
    <name>A0A4Q9LRD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1457p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001457">
        <property type="protein sequence ID" value="TBU10964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1457p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="265" mass="30831" checksum="BC581E6573EC487C" modified="2019-07-31" version="1">MIYSLFGALGIPLDELFYKLFDELFPFIVSNSLVPNRQSSEILKNFFGLIVSGIAGANMNFSHKTVYETLKYIYNSSCQELWTFFLKNKRLCHSLLVNFEGAIAAFHLAHNIQNAFVNLFLDREEYSRTSLSNIMLCLFHLSEFIKFVPKNIFRNIDMILSDIDSDLLQLEPLMNQEELNEHAAECLKQRLSLELLSNKEIMCDCLSRFVGNLLDLTKQNRSEFLEKFSVHFSRFLASNWLFCQYIVRNPEILLILLSKTSITIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE6</accession>
    <name>A0A4Q9LRE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1027p0010</name>
        <name evidence="1" type="ORF">CWI38_1446p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001446">
        <property type="protein sequence ID" value="TBU10984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001027">
        <property type="protein sequence ID" value="TBU11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1027p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1446p0010"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="14099" checksum="1141FCE47A4CBE55" modified="2019-07-31" version="1" fragment="single">MTTKFGQKKTKEIKEFLEYPGFYKVVSFVALSNKIELDGIIVEMVERYFEKNKKFQQKYITDESFTNNNYSFNGDCISFSCRKNENYLFFNSNNFTDREATYISRCSDLIVFFIEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN5</accession>
    <name>A0A4Q9LRN5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1983p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001983">
        <property type="protein sequence ID" value="TBU10150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1983p0030"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="55263" checksum="4556A4D32502D6B1" modified="2019-07-31" version="1">MFRHRPTSQKNIFYDLLDSLRKEHEFIIQENIQLHQKIKDLEDRLHKQDTELEHLQSTILDLKKLAKSHNKVLVSKVDTLKLPLLKLGFDWCLRGTNILNIKLLKTFLNISCTAISLTSSYIGVVSETNGYLIDRNTDQIFLLSNNMRIEVFKDLGVRTPVCKDCKMGHVIFTEDNKFLYTVIDKTVKEWDLNKKKGKIIGEKENKFSRNNYEEKRIKMYNERGGNMYNGNIIGDVYKDSVRGLFYSKGVLLVVYPLFIVIYFIKEMGVGEDFKRIEYNFRERVGCSCFVKEERVVVLCTEGRKIYFYDIENESFKMCDIVLGVVPFRVSTDIKGTLISVGNTEGQILVYKMEKNENNFVLKKTSFLLEYGDSVIGMCFYGDGKYLIGVGKAQCRVFDLVGGGSCLLKGHSDLILGLDVCGKHLSTCGGDNRVRVWELEGVSYKVLCTMFKGVLNVKNIYSIYKGGVNNKGLRTMFKGVLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX3</accession>
    <name>A0A4Q9LRX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1329p0010</name>
        <name evidence="1" type="ORF">CWI38_2543p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002543">
        <property type="protein sequence ID" value="TBU06593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001329">
        <property type="protein sequence ID" value="TBU11194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1329p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2543p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13281" checksum="53095C13F6DBE05F" modified="2019-07-31" version="1">MSRKLEKNKKIKFRRTSNLNNTNNYLLKNIKDLNLNVNNSKPSYEFLLNEGKKFSMYFSKFNNTNKYSEFVTTVVLNLLDNCSGDIYMNVSNRIRKIGSKKLIEEQEYSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS35</accession>
    <name>A0A4Q9LS35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1399p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001399">
        <property type="protein sequence ID" value="TBU11077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1399p0020"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031544">
        <property type="entry name" value="WD40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17005">
        <property type="entry name" value="WD40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="23786" checksum="3A6F0C09E5CB1A9D" modified="2019-07-31" version="1" fragment="single">EISSSDTEILIGTITGAIHVLSIDLLTEHVYLGHKDEIVSIQKYDDKLYSLSDSYFIIFNASTYKSLMHKQINQGYSMSVLGNRSICLCDASGIQIFRDNTTLFNIRDTGRTESIALSDNLTIVGTDQNIFFIFYNTTFSYFTVNVGVNKLSIISDYLIASSTNSEILVFSLSDIQSYKVYKTDVDIIYDFVVFGNEVLIAGDSGISSIEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB8</accession>
    <name>A0A4Q9LSB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA replication licensing factor Mcm8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1193p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001193">
        <property type="protein sequence ID" value="TBU11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1193p0010"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="8">
        <location>
            <begin position="388"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="797" mass="91944" checksum="0EBA3E3695356682" modified="2019-07-31" version="1">MHPHISSWDLYFDKDEITFFNTNYETIIKFIRTLRNNVTNKILIIKERGIYKISMRFLVKIISKNQIYEQPENTIKCIACAVSEIIYNEYDIKMYVGIRITNYNIVSSFGVSVGKVEHLVSLIGTVCRVGCKKLIFKKVFFECLKCKEILEIKIVSNVYKTPKKCVGGCKSKKFVFLNDHPELLIKDFQEIKIQEIPNYQNYCGNFENIFDFSDENSEINFDLDFKETNEKSKEKFAINENKEFNEINENRKQSIDLKCDEEYKENSSEYYYDSNEDSKEKIDMNCANELKNKDFGFKEIDNDYENIKKLNMTDCYLFDDLVNTVVPGDVVSVIGIIKAEKESNGLYKLNIYVNNLKILKNKNILNLKKETKDSDFNVFKDISRNKNIICSLAHSLFKNIYGNELIKIGIVLSLFGGTKKFCGNTCIRKEIHVLLIGEPGLGKSKFLTLTSEILPKSTFICGSSTTSAGLTVSMIHDPITSEYVVDAGALVISDNSVCCLDEFDKLNDFKVLYEIMEQQSFTIAKGGVICTVPARTTIISATNPKYGFFKENKTLKENLNFNEALLSRFDLIFVLKDNLDENYNQELSKYIINNDSKKTSSAISTERSDNKISEMIGILRNDITQNLKMNTETVLYQKELISKYISYAREYVNPILSTQAKNILKTFYLSIRNKENVGIRHLEALMRLTEAKAKTELRMIANQKDAEFIVNFYKKSMNFSSKNTTNTNKKKGNNVKDIITHLKNLAINTKKTVLSYMELINELNNFEMKKSSQEIIELLNHQGYLIKKERDNYQIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC6</accession>
    <name>A0A4Q9LSC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1649p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001649">
        <property type="protein sequence ID" value="TBU10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1649p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29136" checksum="4CFC1649D053FB1E" modified="2019-07-31" version="1">MCQYCGKSGKTVDHLATRYEKKLGYDYTRRHNEVVRFLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVGIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWKKASIGVIIRSEMHEKLEPPLKEAKTEEDGAKNLQPKNNTPLISQGGTTLEEPTNNINKESDLEEDTKVIKEVEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK9</accession>
    <name>A0A4Q9LSK9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1137p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001137">
        <property type="protein sequence ID" value="TBU11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1137p0010"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14133" checksum="E526D55D8B690BC1" modified="2019-07-31" version="1">MMALFVEKYYWIPKAYIREYIRDCQVERVNQTIKRWLAKKLHETGGRRWMKHLNIVVCVYNRTIHGATNKYPFMLFFGQPGFNNPLPRSIIVENEASMIVPAIDIDPDMILVEENAADTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM2</accession>
    <name>A0A4Q9LSM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit beta of nuclear transcription factor Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1704p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001704">
        <property type="protein sequence ID" value="TBU10520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1704p0010"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8579" checksum="7098FD1036836AE2" modified="2019-07-31" version="1" fragment="single">MKHNRNNKNEESSEDMDETYLANLKTTDRLLPIANISKIMKNPIPKVAKVAKDAKELMQKSASEFIAVVTCMAKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX8</accession>
    <name>A0A4Q9LSX8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1091p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 10"/>
    <dbReference type="EMBL" id="PITK01001091">
        <property type="protein sequence ID" value="TBU11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1091p0020"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="762" mass="87541" checksum="A46584E09F744353" modified="2019-07-31" version="1">MKVQKRNGKLENIDISKIERRILSQLKNEPIHINFEELVSKVSSGLCTNIKTSEIDEFTAQMCASLTSVHPQYQTLASRICISNLHKQTFNTFSEKIEFLYKNDINISKDFLDLTLKYKPKIDEIINYERDYLINYFGYKTLEKTYLLKTDRLVERPQDLFMRVALQIHSDDIESAFETYNFMSQKYFIHATPTLFNAGTTRPQMSSCYLLSMQSDSIEGIFNTVKQCALISKNAGGLGMHIHKIRSKDSRIKGTGGTSNGIVPMLKVFDSTAKYVDQGGNKRPGTLAIYLEPWHADIFAFLDLRKNTGKDEHRTRDLFLGLWIPDLFMKRVKNDEQWSLFCPNDVLGLEDVYGDEFEKIYCKFEEEGRAKEKIHAQVLWRAIIEAQIETGNPYMLYKDTINKRSNQKNVGIIKCSNLCTEIVEYTSEDEIAVCNLASIALPSFIVNGAFDFELLIKITKIIVKNLNKIIDKNYYPVEEARTSNLRHRPIGIGVQGLADTFAILRYPFESEEARELNKKIFETIYFAALTSSCEISEKDGHYLSYEGSPISQGILQFDFWNIKPTNWDWDSLRNKISKFGVRNSLLIAPMPTASTSQILGFNECFEPFTSNIYTRRTLAGEFQVVNSYLLKDLIDLNLWNYEMKNSLLQNEGSVQNLPIPENLKKLYKIVWEIKMKTVLTMAIERSPFIDQSQSLNLFIPMATYGKLTSMHFFGWENGLKTGMYYLRTKPISSATKFTVDEEMINESKQSCKIGEPCDSCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT70</accession>
    <name>A0A4Q9LT70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1187p0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001187">
        <property type="protein sequence ID" value="TBU11477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT70"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1187p0030"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="13">
        <location>
            <begin position="13"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="175"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="600"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="986" mass="116496" checksum="D13B708ACDFA80B1" modified="2019-07-31" version="1">MSDTSIDKPLLVSIELKNFMCHKHLFIEFNKMMTCIGGRNGSGKSAIMIAIGLLFGQRAYSLERGNSYKNLIKDGEINAKIRVVLRNIKNYKRSFFKDFIIIEKRLRKDSAPLSIYNLKNNLFSSKKEDLDYILDLFSLRLDNPLNFLTQEQSKKFLNISKPELLYSLFTKGTELEDMTDLHVETENNILQMKQKIDMSTLQLKKLLDEQKIKTNCLEAIYKTKEYENKLKNLESEKEWSRFEKKNIQIIEKERNIKEITENICEFENEKNNFIKELDFLIEDIENTKQERERFKRKHQTEVTNCENKLNNLELQNREISNDLNFLEENLNNKILKKNEMNENISKYLNSDDKRVEKDIKNKKNKILEFEKDFEKLLEIKNEALEEEKKCFEAVNLEMKSINEQNNKIFQLKNQISYFEKVEKNLISFFNENMPNIMNEIKSLKTKDRIIGPIGLYIQLKEHKWYKPVSIILKDIISSFIVFNSEDRESLNNIFKKYNYSGSILLPSLKNNKEIKFEENKKFKTVLNVLNIKETVVLNQLIIFSNIEQIILIESRKEAYSVIKSMPLNVDSAYTIEGDRIKMFRNSLSDYRPRNSNKFYFENSSFKIENLKDELKNLKKTEIKKSAEEDLKKVKKLIMDTFKRIDDLEKNKRNILSELKCIESVQSNKENIKDDFENLDEEIERLKTQKKHLSLKLSDIKNEIENCKNEICKLKEINFNETQDTNKIINTKRLEIQLIDSKISSTKFKLQDIFNEKYTLEIQLEKEKEILKSKYKEICNPRNLEEIIEEENIVLANLQISKNSGIETEIKKDLIQINKKIKFNQKIISNYESKIFKLSECMKKRIEKREALKITISEQASIKFEELTAQRKCIGKLFFNHDEKKLEVIMKIDNTVSGGSKNTLSGGERSYSGICLLLSFWSFLSCPIKILDEFDVYMDNITRKYAIRSLLEFLSEKNSQVILITPLNTKDLFSEFCEIIVLESPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE0</accession>
    <name>A0A4Q9LTE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative tRNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1531p0010</name>
        <name evidence="5" type="ORF">CWI38_1710p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001710">
        <property type="protein sequence ID" value="TBU10509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001531">
        <property type="protein sequence ID" value="TBU10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1531p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1710p0020"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="TRNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="166"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="328" mass="37594" checksum="80BAC5DF25712ACA" modified="2019-07-31" version="1">MLVEYSPEYDDVIFAIDFMNLPIDFAFLPTEIAITIENDRYQGLKKVIDRIIDLCHCDPHDLEIINESTFGHLELIRSKNPADVIETLLENKGPDEKFIPDIPSNINIPCYFNGRSLSFCDLVLFSRLYRRVLEGKILKPEIFNWFNCFQNEISTKKDIEIIEEKGFYLLEIHVGLIKSISDHPNADKLYVETVDMGKEITVVSGLRGRVEKEELLNKKFLFITNLKESKLRGVVSQAMIMCGIDENGTPEPLEVPSEVYTGNRATLTTDKVPVVHYFDSMIHEGKSTVFSELMGKLKIEDNFLMFKDQKVLVEGLEIKTKMKKGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR6</accession>
    <name>A0A4Q9LTR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1073p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001073">
        <property type="protein sequence ID" value="TBU11707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1073p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="398" mass="48335" checksum="BD0ADFF16CB11907" modified="2019-07-31" version="1">MVVCLFERILSRHYNIDEYRDIFVKKSLDLYYKKTKELASWLRAVDYTFLFCYDSQIRAFANVLSNHIQAKSSNNYEININIPNSKSTRNIERIKKCYIFACKNKFKIILDKIFRIHKCIGVITCRFNNLNNHFVSIEDTCKGIFKKTPKKYLSYYIDILLNSKNGVWIKVFSEFENFEENIDKDKMIEIFKTTQREMLCFSHLNCTLYIIDKSDLALDESTYRKKFLKKSIKNRYKISFHSTLPNIKNETTVFLLRQTDKFETYFFVTEFEYLYSTKKSDDSEYKFKILLKFSSFTFEFHFNWYVTKHPFNRFRPDSLYYIYVIAGKFPIYLKFHLIQNEIYFRIEKSITIVPSSNCDYIRNLQNPDRDFTLQQLFYYFIIWYLKDKDSVEFNIFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY5</accession>
    <name>A0A4Q9LTY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0901p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000901">
        <property type="protein sequence ID" value="TBU12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0901p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15470" checksum="3271D50D1C522D04" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTAQTISFDRRRGLESGLNAEESWERASMCVIMRSEIHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINKESDLEEETIVVKEVKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU78</accession>
    <name>A0A4Q9LU78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1273p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001273">
        <property type="protein sequence ID" value="TBU11311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1273p0030"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="42980" checksum="5D5AAD74A384269F" modified="2019-07-31" version="1" fragment="single">MLSFEKNIFTGHLNFLKKQGNINSNSRNFKNESTMNPKCTDERQRKIKNEQIKAVNNLENSAGEISMCDIDVAMLSERLPPPPTFHDTTHQPPSSSCQTSLVCLVETIPSSSANGMTNLNTEAILEGNRLMVLHSILDSVTIVEQEWPRSAILAVQKRFERMPRNGWPATMRYYNEKFGCTLDIDAEIRQEENRKRRRIATCLTEPCTLTDTTEYINLKDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQICYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD8</accession>
    <name>A0A4Q9LUD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0967p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000967">
        <property type="protein sequence ID" value="TBU11947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0967p0050"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="14261" checksum="594FFF536DC36EA3" modified="2019-07-31" version="1">MIFRAHISNLHKSCTQETLLKEFKGYSNILEIKVPKNKYGYNKGYAFIDFSSSVEYLRFIKENNGTFINGKPIKIRKSKNSPLNENMRYLENNRDIIKKYINIKNIKILHINTKEHKYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE9</accession>
    <name>A0A4Q9LUE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1326p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001326">
        <property type="protein sequence ID" value="TBU11200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1326p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="27517" checksum="6B1129FDBAE33D2A" modified="2019-07-31" version="1" fragment="single">ISKQLKNFNDDFSILFKKCFKIEKGHCYNNTINKYLKKLYVQKVFSKLLLGMENGIIMAKFYNVYLSLEICWKSNHNTHFFNQILVFRFYLRVLISLVLICGSKLEIESLNNFINLSFEIFVNRGKLKDKFIQELKILIKDKNIINFLIKENLLIISKLTNKQAQSDCINNWHNMLQENIKKGIDLSFQNIFKSEVCLSCYLSMNYRNNNFEMDKNSNNWQYCFNRIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ0</accession>
    <name>A0A4Q9LUJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0941p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000941">
        <property type="protein sequence ID" value="TBU12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0941p0020"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13866" checksum="F1054CBCA5E0C12A" modified="2019-07-31" version="1" fragment="single">LKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK1</accession>
    <name>A0A4Q9LUK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0799p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000799">
        <property type="protein sequence ID" value="TBU12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0799p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="779" mass="92516" checksum="E6161B1CDDECCC2C" modified="2019-07-31" version="1">MNAFLYVLNLTYCTIQRLKKKESIEFDLLYACNINDSITNNYNRDKGELTNRYALYSEEKNVLYECEGLHRFINDLFLCPNGKDELKHFELSIVKISFPENICLIPSTENLIPMSKCRDKIYLHQKLYFIDFKYCLQLFSNFDSMNTDVPIDKLLDVLYFSYIVGIYGDKNFYKILKGYMIHASGNTLYNGINQVLQYKERFCTNYFNWIISRMIEIFYELNFYYIEDISKGKIGRRFDEKATEGKKFNISSYIIEKIYENKIKENNIKLLHFLLFFKEIEEIYLIDIDFVHVKKIFCLRKIFSRNIDAVTISQKTKIGLVLLYLNNIAVFKNIKKLEIRRTILTENNMRLLANFTFLEHLILSDIIIDQRQYFFPKYLIGKLKNLKILNISAPFLDLSTDPRLFFPDIEQLYLSSIKKKNFNHFQSLKIPEAYYIIVRKISLYFFSANFREFFNKISNFKNLENISIRSKILKSVSGVNNINYQQYHPTLKRLKLVNLYLDDYEIQCIHNFRNLMSIIYIDCTFLHSDSIIFTECKHVKSLQNLKISNCDNARYIFQSIENYKNLICLTIIIKDSNKLLDSNYFIINLKNHIKLSSIHLECNKLNKFPIISEKSNIQLRKIHLCNCNLPSGSVYMSFSSSNLLSNVKSFNFCASFLSRNDLSYLSFMTNCRHLNISSCKFDNCSFFQLFMPDKSYKTVEIFIFDIILQQCDIFALMKLKFLQYIGISLNFLDSSIMYHFKRIYLKKLQLFEIRVSFVQLELKKYLQSEFGEDLQILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL8</accession>
    <name>A0A4Q9LUL8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1195p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001195">
        <property type="protein sequence ID" value="TBU11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1195p0030"/>
    <dbReference type="OrthoDB" id="2188817at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20127" checksum="2B620E01C0F2BFA7" modified="2019-07-31" version="1">MADTNDIIIIGNGPACFTAAIYAATANYKLIVIETHIIDSDTYNFNGCDKICGLENTETCSSYIEKIKEQTKNFSVKIKNGKIKSFGYKNYLYKIEIGDETIYGKSLIIDDKEIFDKYIFNKIDGRMIFKKGCDLDGKETDVSKSVFLCGSADADVEKEAIVLAASGCIAALECKEFLGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP2</accession>
    <name>A0A4Q9LUP2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1261p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001261">
        <property type="protein sequence ID" value="TBU11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1261p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25866" checksum="572A1C4D9E6FA34F" modified="2019-07-31" version="1" fragment="single">DINIYSSSRNSNIFSIKTDTINIKLFHLRSLKYSATSFSDYAEPIFPKLPYILQIELGSNFPKGTLHKIFYRNYFGSLKRLNFDGAHLGKEDEFAFGNYINLFSLCFSGYSKCSEIKFSELFDSNNIYSLQELKLPDIEITCLDLQFLSKINCLKKIYIYSLASQVHIINFLKLLLFVQEIQIKKLSVYGNEIYEQFGTKPVYLIWMNNYENLKYLSRCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV70</accession>
    <name>A0A4Q9LV70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZIP-like zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1158p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001158">
        <property type="protein sequence ID" value="TBU11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV70"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1158p0020"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="22803" checksum="75A1FA9EC93FFBDF" modified="2019-07-31" version="1" fragment="single">MFDGSQTEIFLLSVFLFIFTFLFACSYKVFSKTKLSSYTKCLAGGVILSTMIFHIFPDLYEEPNSCLAPLFSGISFLILFSIDKLYLNATQHDHDSLPENVTQAQALIFVIALSLHSFLEGLGIPAKTGQALKWYITGLIGHKWVEAFALGVSIMTAPFPKKVIMSLIVIYSALTPIGTLLGFYVIEKVKNTSSFMDVKLIMTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV86</accession>
    <name>A0A4Q9LV86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1075p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001075">
        <property type="protein sequence ID" value="TBU11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV86"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1075p0010"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27342" checksum="5586FA58CE1786E7" modified="2019-07-31" version="1" fragment="single">EKIKLACFCFKKLRKYRSSFKDSILERISDIFRSSFKKDSYHIKKANTFVYTVGDHILDEGIKKEGLFRISGKYAYYKFMPGVLAAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQIAERVMKIIKNQTDPSIIEYIVPLIIFSITNENRKMLMYLQKIFRKVDEYSKDNKMGSDNLYKIFTPTIFPNIECYDLNSINLQIEIVKRIFESNLTEIPCFLYEEALSVAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV88</accession>
    <name>A0A4Q9LV88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0695p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000695">
        <property type="protein sequence ID" value="TBU12613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0695p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="12561" checksum="C6EC321D25A1854D" modified="2019-07-31" version="1" fragment="single">AYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPTFPLKEEKREEDGSKNFKPKNKAPFISQGGTTLEELTNNINKESDLEEATKSVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV92</accession>
    <name>A0A4Q9LV92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1167p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001167">
        <property type="protein sequence ID" value="TBU11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1167p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="591" mass="68971" checksum="8B609D35BAF5387D" modified="2019-07-31" version="1">MNLVRLKIMFFDFEISESFCYSLRLLNHLKNLKLLNYQTNKKSEISLFKAIRSLKELKNLAIQNPKFCKTPCNIFLKSKNIKVLCLENIFSNEKTQLLASLFSFTFITKFFLTNIFITHALLVKISQMKHLIQLSLKFCAIESIMFPKPLDFSARNIKFLNIYDTNWNNLQYFDILGKLDNIEFLDISLCGLSASYLKNLSPGCNLKLKSVSCESGILDIDDLNIFGKLEIIEELNLSNRVFHNSVFFKLGENCKFFNSLKKLDLMFVDISIEDLNSIRKFKNLKNLSLTLSGLDLLYVKSYIVSLHLNQFITNIITYDENFKSLLENLNEMNINNVQLAKLYNEIEKRKLYSKLYNARKRKLVSVSESSRYVPFYIQDRNVFWGADYMCQHCNKSGTTVDHSATRCEKMLGHEYTRRHNEEVRCLHLLLLNRYKFKSSKRIRSHSVREILNNEIKTDVKIRNNRPDIFILDQKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANDLKIPMNLGAYIRSIVLKKTVETIFFDRQKGLEEEDGVKIENKKNNILHISEKGTTLEEPTINIIEESDLEEESTVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF7</accession>
    <name>A0A4Q9LVF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1041p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001041">
        <property type="protein sequence ID" value="TBU11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1041p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1047" mass="119522" checksum="2405E9EA4032DCC2" modified="2019-07-31" version="1" fragment="single">DGMDRLDGMDNLERSDRSDVLDSSLYTNTQNNTQNTPYAFKHLISYKQSSPILHISTSPTTLYVLEQKGRLTLLPSKISFDIFSNFMIFHKYLFIIENNFLYCKTKQAFAVIFTYKKRIKQIKFNKNGTLMFLQVGNSIKVYDFNNKILIKEIDTTKELDSNILNSKDGCDNIKFDNSDNTICDNTICDNTIICDNIDRDNNNIDTNTIDNNIDTIDNNTYNSIDTIDTIDNYTTYNLINFIFDEDRNRLLIFKDKIYFYKINNLEGEMTNIKFKESKMEIKKVFVEQKEEKSKKKRYVEDEYGESGEGDSESDISSKGDSNNMLDDSDISSSSSKGDSNNSKSNKSKSNNTNKSNITNTNTKYNKHTNKHTNKPNNKHKFIQDECEDSSYNSCDSTDENNKFTIKNKNRITDISEKYKGDHLNLFENECSSDIRSVVEYSSDEIDEREDIDEREQRDIEHPSYISPNTYDKLRLPITKNGISLIFYNEVGYVIQIKEDKYIDCGDCGVDYGVDGGKEIEENEVYNKSVYNNSNNKSNNKSTNKSTCNVITEVIYHNSKRPSRKFKEKINKIDFTENRIVISNENILKVFMNGDSSRGYGGVGDNRNYNRDDIISNPYTNTNTSTNNTNTNTYTNTNTNTNTNTNPNTYTNTNTNTYTNNISCNDWSVSTVGVITEITVNNRFISIVSKLEGVNYIISIYMLKGKKIIEIGLVNIKGVNSYEYKLGVIYNTNILKVLDIRTLKSKNINLLYNIERCYFSEEGYIFVWGNGFLYKVVDKLCVLLQRIEGVVLCVRGGCCIVYGKGMCVYPLEVEYIRIVDERLAGNEENILKEFKNIIEGVGVGVGCDVGVGCDIKDIKDTSRGNIKDIRSDGGNVKNLNYDLVELLGLMSNNENIKYCKDILYRRGYKEEREESSEEVKHFREYKSVNDSSVSNPVVYNNISKTSNNNSIHSSNANNIYSSKANSISNANSISNTNNNSNNISNANNSSNANSISNDLSIYTSNNISNNYTSLGDSVSKSQNLFEFETENLKKIKSKKYNPYSENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG9</accession>
    <name>A0A4Q9LVG9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0704p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000704">
        <property type="protein sequence ID" value="TBU12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0704p0020"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="473" mass="55809" checksum="3002AEBD5AD45C79" modified="2019-07-31" version="1">MEIELLNEYINEEMYWSALSIGEYLFNKNGNTENFYIITQSLYGLCFYERCISLCNKYPEYLKYYEIQNLFLKCFHKSSSDEKIDESILHEKTVNINVTSIRLEIEQKSVRKFLEANINFDSIRKKLLIDAVMTDNRNFEALFILKNENLCSKNEMLKVLEKLENLELKKLYGEILYPKDICFNFYESNFISPHISEKLAKKLYKKNCLPELFNLGVFMVKNFPKYDRSYIILGIYFFAKNNYNEAKKCFYESVKINKSGGKGWLYLGLAYSLGNESENALSCFRTAEKYMVGSYKPNMYIGYEYHIMNHPKQACIYYRKALKIKNSLNIYKKYVSMLIYYEGYKEAHKILNSDVIDFKNADSITISTFALLNCYCNLFLGNIKEADLHLQNCQNDWKYYATRGFIYHMRVKALDAINNYQEALIRKGECKILRDLLELSIQNLNENINTIVFEFAADLFDFLDLKSLDLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH1</accession>
    <name>A0A4Q9LVH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0779p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28423" checksum="D983EBB2A0B58C05" modified="2019-07-31" version="1">MTGRNQSNIIKPLKHIKNTCLLFVLALIQLISMYLIFMIPFITEILGFSAMAFTKHLTLLFIFLMIRYTYKENIPTIYNSYEIEFSFYFITFISFFIDEYFEKHPLNFEGKNIENFLVIYPIFLVTFHIKILLLLLNIGAMNNINIKHFINLVSSVSVISIAETVLKPIISNTKQLLMPRIFIYLSEFTLSSFILYRYISISQATLFLIFYISLIFTLDSNLFNHVASNLSYLFDNNEYCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN7</accession>
    <name>A0A4Q9LVN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0636p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000636">
        <property type="protein sequence ID" value="TBU12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0636p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140:SF37">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="881" mass="101997" checksum="E3401338454D6D5F" modified="2019-07-31" version="1">MFLPVCFSNLKEISEKIWRLYIQSMLNTTKLSFFFLYLLTIGFLRPLRCVRITLNFINEKYDESIATCHASSYNHIKFHNKIDSHVLELDMTHNNNKIFSQPDIAMSIDTNQKNIIIGDQNMKSDTSVESQNDSIDASSNEDLNNNMYYGGEGVEYQNNLEILKATNITDKESGSIDETTDKQPPSFSPNKSSLIFDYNDAYMIRSLCFDGLNNERLTEIHLNIKDITKSNIDIIMCRECLNILCYGWNYCIPGLNNENFLDFIWFFHDLSCYSESEALDIFYKNLLPFLFSYIADKSSLNVFNSQNFDFSNYRNIFLPFLPVVYDLIEVSFDLTTKELVFIEKKEFRKYNLFGLESTEEIIIRTTPKALNIMQEADASNIKYLVCKLVCSFQIYGIRISGDNIYHSEPKNAENTCNFLLEHPGIFEMKTDPFSAFGIKESKINKEIKHIELDRISVPNIEVLFLLIPKKLESLILVKCYSATMGTFLAKMTKKFENLKVLQLLGTMLQNGFFNTLDLVSIERLDLSCCTYRGILKYVKIKEMKALKELKLDYCHINYKVVEALIRTESLEVISIKEFVFKNIDGFNVCLNKQNNYRCLDVSWCIFEHLFTEIFFKDLNVETLILANIKNLQTIIIILSQNSLYISVKCLSLSGNLLFVGIFACLDKFEKLEFLNISNLDKESIYFKISDVDFPSLSLDIDSNRILNEKKTKTILELPPSCGKERNPSNFDFITGFLECLCATGLSTSLRGINLSKNELDSANILRIEWLVNLNYLIVSFDDRIFSEFLKEYGALKFSNLETLILVSTNINNDIYHFVMTLPLLRNFETRECKFVEDILVSNLNLYPMVLEKIVFTNTIYSSYFKSVLEEMHAKRINVIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW5</accession>
    <name>A0A4Q9LVW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0601p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000601">
        <property type="protein sequence ID" value="TBU12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0601p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16395" checksum="1363BBE4DE522501" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMTLRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW19</accession>
    <name>A0A4Q9LW19_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0310p0020</name>
        <name evidence="8" type="ORF">CWI38_0585p0030</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000585">
        <property type="protein sequence ID" value="TBU12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000310">
        <property type="protein sequence ID" value="TBU15613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW19"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0310p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0585p0030"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU15613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45045" checksum="14CDE9917C9B0ADF" modified="2019-07-31" version="1">MENILLKGIKQNTKAEKIERIQRYEITGKKLEEIKSFEFVNIELQNKLNKSGFIKPLLIQRLVIPYFINKRSIIVNSHTGSGKTLAFLIPILHLKKKSLILVPNSILQEQICSVIEMIKDENLNILKIKNSKDLKSIDNKRYDIIVSTPEILFETENIILLKNIRYLIIDEADLIFSKNNLKNLEKLFSLIDLKKVCLSVFSATINKIVTEISCVFDVTKISVFSLNAINHEFLFCTTNSLKQISLKTRVDEGIPFPCLIFVKKEETAVELSKRFEKSAVFFKNDQKVLDDFRLKKIWILFCSDRLSRGMDFYNVKSVINYNFPKSKTNFIHRIGRVNRNNFCDQKVITLFTKEDFLKLDRVITVLKENKSEIPESVINIATKAKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM1</accession>
    <name>A0A4Q9LWM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0840p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000840">
        <property type="protein sequence ID" value="TBU12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0840p0020"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="696" mass="76306" checksum="A62C3C49AC821529" modified="2019-07-31" version="1">MSGPNEQKVRTSGAVGIDLGTTYSCVAGYVNGELEVFPNPDGARITPSVVAFDDDDRRLIGTAAQYKLNLQASRVIYDCKRLIGRGFDDPKIAKAIKNWPFTVVRYDKEKKMEIDTVLDKSVVDNIRIKMKIGDQIRYYDPIEISSYILTYMKEAAKAKLGHEITTGVITVPAHFNNNQRDKTKVAAEIAGFTKLRLLNEPTAAAMAYGYGRSKGDKVSKGEETVLVFDLGGGTFDVSVLRFDAASENESGVAEVLATDGDTFLGGVDFDNALFDYAMSCFTRKHPNVDVKKITDKSKRRLRAACEKAKRALSSSTTATIDIEFFYEEICFTLDVTRSKFEDLCYPGFVRCMERVKGCLYGLGKGTALYDERTGVLEVKHDTAKVIEEQKQQIGKVILVGGSSRVPKVKQMLADFFGESKLCFSVHPDEAVALGAAYHAVMLADDVALKAEESILLLDTVPLTISIETAGGVATPLIPRKTTIPYKTSQVFTTYSDNQPGVTISIFEGERSCVKDNHLLGTFSLTDIPAAPRGVPQIEVTCEVDANGIFKVTAVEKSTNMTNSLTITNMKGRLSEEEVSKMVEEAKKYNDSDKEFKERMNSKNNLEHAIYSMKNVVKEGKMDESVKAEMLKKVQSYEDWLSANDNASKETFDAKLQEVQAMMGGAGMGMGGQPGPDMDMGGAEAADKTGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS9</accession>
    <name>A0A4Q9LWS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0520p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000520">
        <property type="protein sequence ID" value="TBU13134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0520p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10832" checksum="9D0D150ED28D410F" modified="2019-07-31" version="1">MCSVEIIPYVIRSTVVLLVIERSEMQKHLTFPLKQVKNKEDGVKYLKPSYNPPYIYDEETVNKFNEESYLRKEIKVVREVKKIYKRMTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX27</accession>
    <name>A0A4Q9LX27_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0590p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000590">
        <property type="protein sequence ID" value="TBU12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0590p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="25418" checksum="74B210CEACC66BAC" modified="2019-07-31" version="1">MFRSINKKDIFSSLKRINLEKEKIIEKYKSSVKDNTYEQLFEFEIEFPENKKVLNLTKKYALHNYIRKSDSKKLEKLLYKNLHLDEFSLFLLIEKIIDSKRYILAIKLLHFTKNNHMSSNIKNIKNIKKLKEIKRNIKNIKNIKNIKNIKNIKNIKRNKEYKENKENKENKEYKEYKGYKEYKEYKGYKEYKGYKRYANNVTLHQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX86</accession>
    <name>A0A4Q9LX86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0451p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000451">
        <property type="protein sequence ID" value="TBU13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0451p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="37063" checksum="60D25C66C49315EE" modified="2019-07-31" version="1">MIKDNNRDFYLKLLDSDKFMNKVKIIEYSKFRSFYLEYKCFYDYNGCFCNISITLDELHAKKFTYKDNIFKKRYKRNYVFNVDGLESLEISFSDLFIENKICDKNESVKYFRFTPKNIADYHYVYELINIMVCLKEVYFDAIVNLKLSRSVTRIFYITELYLRNVGRTMYFLKLSENNQNFDFRTTNEDNLDSECHKISEYLFFRLVLYFTKIQHKKIRDDKIKIFKRDLIFIANLEHIKELKFLICDIYQETYQSIKMLFITKFYIELRYYRGDENISEEFIQSLKDVYKPKNIDINMLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD0</accession>
    <name>A0A4Q9LXD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0773p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000773">
        <property type="protein sequence ID" value="TBU12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0773p0020"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="93"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="289"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="49870" checksum="799D423AC218602C" modified="2019-07-31" version="1">MDKIIKEDTKDEKLTTVNEKEELLKNLLEKLKIAETKYGIDITEILKKDVVRTDDVTTTQFSKWEEFIKNTNLLKGIENMDYKYPSPVQAASIPYSLEGRDLIVRSKNGTGKTAAYTIPILERIDDNKMMPQCIILVPTRELALQTSKMCKKIAKYMKIEIVPIYGGIDLHDDILRLTQGVHVIVGTPGRILDIAERKIINLKLCNILVFDEADKLLSFEFKDSLDKIIKFLPVDRQILLYSATFPSSVCEFVNSYMNKPLHLNLMKELTLKGVHQFYACVEPKNKLFCLKTLLKQLNFDQCIIFCNSIQNVELLTKKTTEMGFPSYFIHSKMMQADRNLVFHNFTEGGCKILVTTDLITRGIDVPTINCVINFDFPKTTESYLHRIGRAGRFGNYGVAINLIGPSQDLRDLENALDISILPVSDKKFQDFMKKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ7</accession>
    <name>A0A4Q9LXJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0413p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000413">
        <property type="protein sequence ID" value="TBU13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0413p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12790" checksum="6B2220BE4C329490" modified="2019-07-31" version="1">MHFFVQRKSRFVLVGLSYKFSVEIIPYVVTWDSIVPKYHKTGIYTSIALKMTVETISFDRRRRLDWERASLNNEEDCVKTENTKNKEPTINANKELESEEEIEVVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL3</accession>
    <name>A0A4Q9LXL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein localization protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0691p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000691">
        <property type="protein sequence ID" value="TBU12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0691p0020"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="821" mass="95482" checksum="E63CFB9CA9A01456" modified="2019-07-31" version="1">MILRIQGPTKFVRLDIPLTSKLDEILPEKFNTSTYKVSTDEECKNVILTDVPIQELKLQPGQYLYIHYSIETDTLLTTENKPKESNKVVLKYKSKDKNMSEDMSKDKNMSKDMSKDKDMKDKNMKDTSNKDIKDTSNKDIKDTSNKDNSSNTKLPKKCNHPSNAMCPSCAPDYPTHQPKYFSFFSYTNHTSVSPTSFPKRCEHPSNTKCSSCNTYFHIIPQIYRMVDHILITANCLPQIENLIINYKNTQKQRFGLLIGKYEKYEFVEEGIQGRVMCVYEPEQQNFPDGFCLDEDEIKIFCEEQRKKRMRGVGRTLGGGVSGDGKKMGDGKKSGEGKKNGDGKKSGDGKKSGDGKKSGEEMGNISNGSKHKSNGSKNKTSKNISDVSKDKVEVIKYKNALNLCKILDTFKLEIIGMIYTDITKNSNIFLSSLELNFISYFQRIFPFKYRDCNFNSRFFTIVLKKDKEEIVPHEYMVSEQCMSLFEQDKVFCSTDRNVLGVKDLSVVFKKKEGDKIVSERDSKFFPCEYMIVKLTHGIPEGSSSNNRDDSNKKDDSNKRDESYKRDDSNKRDESYKRDDSNKRDESYKKDESYKRDESYKRDNIRETNNIDTPNTNIDDNIFISKEYFNRKWTWKKVGRYFNGDFRLEKFSNLNVLLRMMEDNCNTEYIIEAIKGDKKQLRVFLEGEEFRVWRGNFKKYECVEWECSVCTFLNKEGIDECEMCGVRCVGADKNKCRSFFLIRKVLMSVRCVGADKNKCRSFFLIRKVLMSVRCVGADKNKFRSFFLIRKVLMSVRCVGADKNKCRNVLYLLYFLFKFYFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL9</accession>
    <name>A0A4Q9LXL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0401p0020</name>
        <name evidence="1" type="ORF">CWI38_0475p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000475">
        <property type="protein sequence ID" value="TBU13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000401">
        <property type="protein sequence ID" value="TBU13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0401p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0475p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15408" checksum="6031905FEB498B51" modified="2019-07-31" version="1">MYTEIEPPKIKRRKLSVTENNINFQRSRSNSLGTNENYIFDRNKLEEPLVIKFGTKKLLSGKGEYFLLLVKHVLKLNRSIDLSKYKRFSRCLLHVKAVNPPKNEHWNDFIAFLVKEEIIERISSGKFGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN0</accession>
    <name>A0A4Q9LXN0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0737p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000737">
        <property type="protein sequence ID" value="TBU12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0737p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20491" checksum="AB0B145CFDA41C7A" modified="2019-07-31" version="1" fragment="single">MFLYLYSAIFGEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRFIHLLLLNKYKFKSSKRIRSHSVQEILDNEYEEIRVDTRIKTDVKIRNNRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXS3</accession>
    <name>A0A4Q9LXS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0727p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000727">
        <property type="protein sequence ID" value="TBU12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0727p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="258" mass="30120" checksum="1DFDCB9B0DDF1529" modified="2019-07-31" version="1">MYANIYKLTKKCVTQVVQLERSFIIIVVYIVWIHSAESLREIHKGTKKTDAESHATYHLLFIDDLNLLEVKKFMNNIRLEINKENRGIPTSKSFEELDNAVRAVLVKNKIHLLPGCKERLQSVEFKNDHMFLQLLDSVTKKKLEEAQHANLYNEIKNRKLHSKLFSDINNELVSVSGSSRWLKKGNIKPRDEADRNVFWGAEGMSQHCKQSKKTVEHLATRLVRCIHLLLLNKYKFKSSKRIRSHSVQEILNKKFAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXS9</accession>
    <name>A0A4Q9LXS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0379p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="17188" checksum="705613352F940BEE" modified="2019-07-31" version="1">MNRKLFKIKPNTEIIIKVFLSKNNKNPPKHILIERKKSFRGEKLRNLKSNFVNKFGNIKKISNISNMEDTKNIEDIKSMKGIEDIKSMKGIEDIESIESIKNIKNIKNVSLFKNLFVIYLYDWSYIGNIKDFYLPCGFMKNPKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU8</accession>
    <name>A0A4Q9LXU8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0400p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000400">
        <property type="protein sequence ID" value="TBU13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0400p0050"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="54166" checksum="501E4307BDEE1623" modified="2019-07-31" version="1">MTDEANEFLKVIWLEINKEKSATNDACCEDTDSRGIPTLERLFHTRLNAKKLFSAINQHAISLINYHIGVLRLEPADFSQLDDAGRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVEFRNEHMLLQLLDSLEKSKEISIRRAAILKVENNNKTHLAQIKGFLKVKYRLVEEVTKKSLEKSQLTKLYNEIEKRKLHSKLYNARKNELVSVSDSSSWLKRGNIRPGNEAVFCYIQDINVVWGADGVCQHCGKSGKTVDHLATRCEKMLSHDYTRRHNEVVRCLYLLPLNRYKFKFSKRIRSHSVHEILDNEYAEIRKLRKYDLLANELGLVYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETIFFDRRRGLESGLNAEESWKRASMGEPTPPLKEEKREEDGAKNFKPENKAPLISQGGTTLEEPTNNINKESDLEEETKLVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY29</accession>
    <name>A0A4Q9LY29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small nuclear ribonucleoprotein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0348p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000348">
        <property type="protein sequence ID" value="TBU13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY29"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0348p0020"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="8310" checksum="5330EC3787483ECA" modified="2019-07-31" version="1">MDILIKPDKENPKQFLARNIGKNITVNLKWDEYFNLHLKNCKEKEGDVIKGDVGEIVIRCNNVRYIAEHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI8</accession>
    <name>A0A4Q9LYI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar sorting protein 9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0429p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000429">
        <property type="protein sequence ID" value="TBU13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0429p0010"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21627" checksum="AEEF00290A00DE5A" modified="2019-07-31" version="1" fragment="single">LNNSLINFSKLPFYRTPTEKINCYMKHIKFCYKEIGIEKGAEEILPILIYSIIKSDIHNVYIEKLFMNYYKHKNFNRCQHNCTHLNNNFLNFVEPKEICDCLDECMNNYNETTYYLALLDTAISFIERIEFKSLNISREEYNAFIDQKIISFKEPNKIIEISSQKDNKISKIIKYFRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW3</accession>
    <name>A0A4Q9LYW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0386p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000386">
        <property type="protein sequence ID" value="TBU13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0386p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="39437" checksum="510EB7F0DB0BBF26" modified="2019-07-31" version="1">MSIAYLIVVTSTGNRNDYFRCYAESSSDSREYNRRCRDYSSSSSSSESNCGFNTLVCRDFRCKPTKATKCFTATECVPAKPAKTLDTEIYHIEGIIESAVRNIDPVLNRAAIAFKNAVIECIERTDRNLLEKIATALSNLKTKISSIINTGEATELTNVLANINQTNNALLNGVESLLATAAQSTTTTITILAGDTQPNIIASVTNLSTGGLLFTILGFINTASTGANTLFTTTTNEQITAITGIMSNSTTALIADVATEIDNTGKILKSLVAAAAGQQIRCISEYLCQFINDIKINMDCLIRDIGREIICCIKKRCGIPGYEYKNSFRPPVFYGKMNSPRYGGVCNRPYLGLREDLDLGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ3</accession>
    <name>A0A4Q9LYZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0274p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000274">
        <property type="protein sequence ID" value="TBU17652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0274p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="24950" checksum="A0792B5B26E680B3" modified="2019-07-31" version="1">MIISLVKNTVVESPKHPTDESMDGKENGGSSKKLEHSGNANYTSSTQSEVSETDGKNIFIGRNPERLEDENGVITTDVEPSYFLLQTGNGTMQQEPGAEDGSNSNGVSCNSSNKICGCCGKKRICRINCYCCRSRGSSKPSECCTDSAFITHCTDEVVSCFRTCSDDVIKTIECCFNYPFKQIRRCCHHHSQCLESYRDDHLTCDDDCCEKLCSACCCICECLAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ99</accession>
    <name>A0A4Q9LZ99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0232p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000232">
        <property type="protein sequence ID" value="TBU18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ99"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0232p0030"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="478" mass="55821" checksum="55DE196061F8F33A" modified="2019-07-31" version="1">MVFFFDNDKVVPKKEIEIDKELLANKTNERLEISNEKLEMFKKFTKMVNSNGKDLESKHFVYNKYSINNETNICAGGETLSEKQIQNFEKEFPKINFDANFYFNNFSIHEKVSEENRIDNRTNNLSPSDIEVKEEVINKQKSEKIVEETNDNIDTLENILETNEEKKFSSLPKNGLYDTTSSKICSDLEVQDLFKNKADLSPIEQKINNCFNQNNTINMNIQPNNNNNNNNFLNKQNIKEQEYTNYEMMQQFDSNHIDQRAVESILLDFRFRGAISSFNNRGHVSREMRHRFRKDSSTVLTPGVSIPKSNNIPTNFMNFGNPNLIHQQMNYTNLPMIRNPTIPIPGIENGPMNMGMNMAMNMGMNMNVNMHDSECEMEPQFSSSGMPNTIEKWDAIRRLIKRKKNREIPTMQRNPITTVVQTQKNVCAHCGTEKTSLWRRFEGMFVCNACGLYYKMHGVRRPNFLKTDNIRRRKRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN4</accession>
    <name>A0A4Q9LZN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0200p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000200">
        <property type="protein sequence ID" value="TBU19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0200p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14539" checksum="530CAB5ADFB05C43" modified="2019-07-31" version="1">MDKATALVNIYRDKFCGNKRLETIFNQEAQNIINLKESIKSMDFSQNKHDNDIQVLKILFDLEFRISHIEKAILGNSILVMSCYAKRGYGFTYNSIIKQAEEYYEDSHLSIEYFSIFSLLFIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW9</accession>
    <name>A0A4Q9LZW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0190p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000190">
        <property type="protein sequence ID" value="TBU19835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0190p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="28090" checksum="3EE1678F420745F0" modified="2019-07-31" version="1">MKYLSCSTCNLRIMRNLLDGNSRNNYIKTNDRRSQKKKLKKAQLANLYNEIEKQILQSKLYNAKNNKTVSLNDFSRCLKKGSVRPRDERRWYFSTFHNVWLKLDCLATRFEKKVNNYTRRHNEVYAEIRSETRIKTNNYNVEMIPYMKTRDGIVKKYHKMYLIRCKTLINLEAHIQFIKSPLIDEENLVSLGFIEEDEMHEQPSPSSKQVENKEDSSATQIEKNILQLLLDGLTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M027</accession>
    <name>A0A4Q9M027_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0262p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000262">
        <property type="protein sequence ID" value="TBU17940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0262p0010"/>
    <dbReference type="OrthoDB" id="5987059at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="908"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1451" mass="169155" checksum="3D20FF8DEBC2473C" modified="2019-07-31" version="1" fragment="single">MNEKDEKNCLEKMFDKDENKQYKKYTIEITERIGLKFDIFEKFNKINNNVEIFLCHHIKKSDFLIFYEFIISYYLPVHKMKIKKFYTILYLLEYFRVEYDNKLRNAIKIIWFSLMESNEMNNFDIKNPSIHFSKQDYFLNALFKKISQEFLKLLNNEKEQKFLCFIKDNEFYVYDGYKGIFTDDRKHVLVINYNFDAFFYKKVVVNHKSQCLFLVFLNTLNIKYLHIKSLNRANSKSFCFILDNLKKRIDEIVFHWGYIYDEVICSLNANLNLVNLKKIVFIFPKIVTSFIFNENLAKINEFIFFEKNDDEKYAVHAIKEEDLNIAEFTIKSLKHIHQQCSIGKSIKKNKNISKENENFYLKLLNGDNFESKVRIITYFECKNENPGVKCFHEYQGCFKNISISFNELNDKKFFTTENTILEENIKCIEITSSEIKSDFLKDYLNIKRLERLEINYLNIYIENTLKVLMGRKKNVSSEISKNTKIKAANDADELKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTGCKMQNSGLDTLKSPNTPLPSSVEVSTCEPSHEMTSPCTLAIPEGNRLMALRAIFDSVTADRRNGLELFFLQMPRNGWTELHMYYNEKFGCTETLEVLKKLAQSEMVKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISMKEIGKVVVRTRKNPNEFVLIKVLDLINQGVAAYIMQAAQICYDEATLLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNSSSVIDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSESVESEHVVSRDEIVSFWSKMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVKIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQADWFYSGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQLEVERRGLLAENQLGAVRAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLCHLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLESVSVYKYLGIIEDSRGIPTLERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRVELGRGLHSVELRSEHMLLQLLDCLEKSKEISSRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAHLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIKSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M033</accession>
    <name>A0A4Q9M033_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0449p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000449">
        <property type="protein sequence ID" value="TBU13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M033"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0449p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="29455" checksum="2AF116F651770CFD" modified="2019-07-31" version="1">MQFSNLIWNACIFQYAYFINCADEQEEPLLEHMDSENNHKDDHKYQIYSSIRNFSEVILKKRLHKHEHFIDKYHIHCKMNLNQIDTNSESIRITMNDQIYYSRNYVLAWKLDPQYNMSDFIAEMNHSIFICNEYIEAFEKTNHTILKMKFEGDIIYGKIGNIKSNVVFSLYLVQNLATLKNLKTFNRIIGGSSQKSKYKSFILILNERLNSYDRFVIFTEYFKDDGKNFDIGYISVMISQKYSEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E1</accession>
    <name>A0A4Q9M0E1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0137p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000137">
        <property type="protein sequence ID" value="TBU20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0137p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="432" mass="52460" checksum="51EFC39682498CB9" modified="2019-07-31" version="1">MKKQILDRLEKEIEIFLKTNNQNVTIDTIYNEVIFKRINVFLKHIINIFMSGYKKDKKRLQFFSFLINEVSSKNDLENMNSKFQYREDNLPNYRGYLEQNRLTNYFFLSLRSEESCEIKIISTILIQDLKLILQKIFRHFENYQDMLSYFKDNDTDKLKSKYVKKTDKYVFYEVNNTVFDEYFFKHVFDLIFEKTIASNSFLIKYILSYNDEEYINERKFIDETWNLTTENHLFLDAEINPEEIGKNFGSFLRNNIKNTKNSNNYRNRIYILLDVRKSFEAFCQFYIEKMKSQESNDNLVSKIDEDLFMKLHFVSSDFRKLINENFIFLNYICSLIYLTKKNCEIHIFFSDFKQNESENCLKQKYFLVSRYKKFSQDLKSNCNNSDEDESKLLAEINLRFKNEYKMLFEITMRGMLNSKEDFTFDNKIIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F5</accession>
    <name>A0A4Q9M0F5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0130p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000130">
        <property type="protein sequence ID" value="TBU20114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0130p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14697" checksum="795C5578C4D5F624" modified="2019-07-31" version="1">MVVEFSILLLYIHDCRLTFIFFGLFTVIIVSIRVWHLWFVNIWMYIERFSLDNLHDGRYREYIFCIGSLYNKMGFIFNTLLHSFISVTKFISSIQCLDTRNEKLPEDYNNSYNNMCYIFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I5</accession>
    <name>A0A4Q9M0I5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0129p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020357331" evidence="1">
        <location>
            <begin position="24"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="733" mass="87425" checksum="C6B739A42B8A77AB" modified="2019-07-31" version="1">MKSFVFIKNFLFLYFFFVREISTSDIQISFLLEKEVKSTFKKIFKQSDNKKIYGKFDLYGKLLSINHKKILSNEIYNKDEFIICELKKVTLNYPTDFSVKFEYLDILLLKKYKTSNEIYIGNIVSYKNFTLFMKICSDTENNLKKRINIGNIFQILHLIDFLNPIDKYFEKKIVKKIYEIKFKRYTLYSDFFDYYKKFIIYQRYIHEFIYFIRNIITGKNLDILINKDFLVIDNNYMNLIDDSFKKQAVFSESVEFVVTKNAILKISMFDKKDRNTLINSIVHTIILCHIKKISILTDCPFDRITHIFERKSLLSIKNNFRTSYSCPDIFKIFILIEKYGYSDEITHIRLEKINISKKTCNCISKFRKIKSLEISFCKKNSELFLKKTLETSKELEILKLNDMYISRNTLKLISKMNLSKISFKSCRFEKLQEIFFTLNIPLCIRKLNFCRNTIEYSFFIYLEAIKNLESLNISFAVIMSQLPTNINLGNLKKINLTGIKSFYLGNVLMYTMNNLRKIIISEIFFFHFLTKPVDMNNVFYKIKEIKIPFSLSILRYVNTLKEFNCLEKLTMENTFFKQNDFLKLDGVLFIHTLQYLKISAATFGNNDILILKKFNNLQFLGLIKCSLDKVESNLFNIDLWKKTIMSLDLRFTKINDEDINNILQFENLKYLSLTIFSRQRQNFIVQILRFSKTLNLQELILFNSYLTDQEILSLIQSKVSKRTFFIENEYIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L8</accession>
    <name>A0A4Q9M0L8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0379p0030</name>
        <name evidence="1" type="ORF">CWI38_0384p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18787" checksum="94541266693C9851" modified="2019-07-31" version="1">MIGSKIGTHPIPISPSTAIDIFKNVFSNQNIFFKNICLYKPSITEIYVIKSDKIPFDGYFYTQKKLLNEQNIKIQIEDTICHTIRRVIYISSNYDFFIVGYFHIDRNVNDIYFSHYFNISNLIYQRDSFIYDIFISNDTIPYTLDIEYIQSKIKELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q4</accession>
    <name>A0A4Q9M0Q4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0110p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Q4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0040"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="630" mass="73291" checksum="A039CED1CC042D90" modified="2019-07-31" version="1">MRKQVKNILKLQMLQEIFNKNLNMTLKLPQIAVIGSQSSGKSSVLDQIIQKDFLPRGTGFITKCPIIINMRYCNSNVEYAEFSHILDKKFTDFILVKNEILNRMMVLTKKAFIVSKEPIIINYYSKNTFDLTLVDLPGLIKVPLDGQPSDIEKQVKEIIFEYTKDESSLLLCIICANMDLANSESLNICKKIDPEGKRTLGVLTKIDLMDLETDCTAILKNKNNTLLHGYIGVINRGQSDLNSSLTLVEAKKKENDFFKNHTKYKCFYPKIGSKFLIAKLNEIFHTLLVDKIPKLRKIIEDKIKDLERELDELGENVDINNDMVFTSVLQYCKIVEASLKNEEYISDKKFMFFSKNEDVFVVLIKSIFEKIKKMEFVFSGNLKEIIDNSNTFFIDESVFKHILKNRFKEFNDEIKKSCSVIFNIAISKINSVENYRFVNLAIEFNKITSDFLNLQYLRLMETIQNYSEIQMSYFNYNHPDFSKVAIFSNVIQKIVRKKKNTALSLKFDPWNSLFGSKNAENISNENIYCDESFEYELVSKATDSYFTIIKKSMIDFSIKSCYFYFVESVITKLYAEICKKIDLLEKNIFIESIDVINRRKQIKNELTHLKKAYLVFDKDLKSENESFCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W9</accession>
    <name>A0A4Q9M0W9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0092p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="269" mass="30627" checksum="DB21389BB4D74D96" modified="2019-07-31" version="1" fragment="single">MLKHVKIRTRETKSEEDGKSDIENNRVGLKDETNVFYEKPTYVEFEKTVEELDDHNLVKRCNSNDLSQVEIEKGKSPLCANLIQYVGGEQSLILDENAQETPSTISVTDEVEKSNYQKQNNMIYGTGPQKIEMLRTNSTDRSEYHKSNSIYETMLFSKPGLIRQVRKRSFTNRNSFGYQTQSLDRCSSFLHVLGTKSRIEEPLGKELSEVQKARTYERSALLVESLTGINLENQTNGNHIDTENGVIGLLNTEKTPTIRNATGNHLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A0</accession>
    <name>A0A4Q9M1A0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory subunit of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0311p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000311">
        <property type="protein sequence ID" value="TBU15521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1A0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0311p0020"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="99"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="433" mass="50290" checksum="F471BDC2BC03BB3C" modified="2019-07-31" version="1">MTLTKRTNYSDAHIKIRIIKALGAIKPVGIHKYFYLVKILRNMKKPNIITADNIWTFLNTTFPVEKFDEEDFDRIFDNKMSFDKNFEPYKPFKMIDNNITVHPLVMASVVDHYRRCDSKRVAGIVMGKMDERLFVTKSYAVPFSEDDKGNWFFDTSYSDKMYALLNKVDSSEKILGWYHSGPSLHKNDLDITKSFMRDLPNPLLVIVDVKAFNISEQVQIFRLVDDKSGKKNDKKFKYIPCVVEGEEAEEVGVEHLLKDIRDCSVSKYFTNVKDIKSSMEMYEKSLTVIVEYLQKVKNNEIRVDQKILRYLQKCLNEVPIVSEDDDESKMALFTSLLANAVVKITDLVLSRKESVSEIQSIVLKKTVETISFDRRRGLEEEDGFKAQNKKNNKPLISQEETTLEEPTNNINEESDLEEETVVVKEVEENIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A5</accession>
    <name>A0A4Q9M1A5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0277p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000277">
        <property type="protein sequence ID" value="TBU17632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0277p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="89090" checksum="2C591843B2697CAB" modified="2019-07-31" version="1">MLFPDFDNTFAKKQLYYNKVPKLIFGIFNEADNTIRRCYGKHKFIKKIFICSLHEKTCCHIRLSRLKILYSESFFLRSKKFDTICKHKHPRDYFLITKYNEMSFKYFIKIIHYEDGLMNCLDIKNFLCILHWSYIIDVPLNKRFDCLIRSCLQRLHISNLNIVIEEIETYRNRLPRKFFNWILLHSLRNFFDIFGIYRKFLEVTTFGECLNHLNADISLNINLFINVLEKIHKLIHKFGLSHPLTIIFYFCNVKKVSFRNIGFIKSNYISFLEDIFQKDIFVIRIYDCSLLNLLTNLLKIKTLRNAKKIFIAESPITNASIRLLSYFIHLEILSFKMIGKIFNFSDSLKHFSYKSKNLMVLEIYAHQIISDLQFLEYIIGFKHLKIYISELNFDNLAPVFSRSFTSCMLLTNLRLPFNNINLNQAIERIYFYENLQSISFQSVLRSGCAHRNNDFEPKFITKLKTLYLTNFFIGNDDLFMIYSFKNLKKLSFKKCSFNSSYNLPKDGNCVISICKFENVLESLEIINCDEFLSFFNFVYSLYNLKKLVLNAPYMSFTTELNFLNRLRLSNLSLFRISELLIDKSVLQCLSLNSNLTHLYIYNCPIKRNYFIDMPNYGSFFKKLVHFSFICCDITIQDTFALSHLTNCETLDFSFSRFISCSISNIFKKENTYKVKNLNLKYLFLLYEDSTAINRLKNLTFLNLSDCILYQNTLCTLKFNGLKNLQVLNLSGINIPRNIKKMLNEEFTILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I0</accession>
    <name>A0A4Q9M1I0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0255p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000255">
        <property type="protein sequence ID" value="TBU18011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0255p0010"/>
    <dbReference type="OrthoDB" id="2193379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="22989" checksum="D381CFE8EE761820" modified="2019-07-31" version="1">MNTDKKNVFILFYLMTEFCDSKYIIKKNKRNTICNHSSTLSAMTGEAKEFLERLATNDTCFEDTATLLEGVIVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R9</accession>
    <name>A0A4Q9M1R9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0262p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000262">
        <property type="protein sequence ID" value="TBU17944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0262p0050"/>
    <dbReference type="OrthoDB" id="2201248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="27644" checksum="931386C167E455D4" modified="2019-07-31" version="1">MNVCFICIKSFINSLFNVSDKISIKMLTLKKFNCMKKFVIQRNKIRTLLFLFLAVLSYSLLEGRHRILLENNRNLVLTAENSIVRLKNDKELFINQNLADIINFKESSVIDRVKIVLNNKYLCKKENDPGIVLCDGDTHFSDWDIIMTLKGYRFMLNTNTPLCLTKTNYDSRRTTEGYYLNALECKNEIDLSEYFEIERLSEEPSNDHRNDSSGNYNNHGSGDPRYRSNYETCTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V3</accession>
    <name>A0A4Q9M1V3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0031p0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0100"/>
    <dbReference type="OrthoDB" id="568194at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05379">
        <property type="entry name" value="CAP_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1143" mass="129957" checksum="C266424E95BE5B42" modified="2019-07-31" version="1">MIIFILGIVLGQYEKDMLRLTNEFRRENNLKELELYYPLEKTARMQAEFMCSIMKITHDGPEKKTRTLDRRLLLNDFVGENIGENIAKQQGDNYGEVFRIWKRSDKHKKNILGDYTYTGIYTCKDRRKNRYWVQVFGKPASGKKSSKETKDRDSDSSKKESKNDENIKSRIDNNDVTSKKGGTEITAKVDNKDGENKQVKNLEGKNDGKNKEENNTESKNGVNNQEGKDKGKNDKESKIDESNNKDDKKDKKKDENKGNENENDKDKDKDKGNDTRNKKKNDNKANKSEKDDKHEDKGKKEEKDNKEPKNDKNNGNNKSDDEKKDIKKTENGSDNKKDKDKNKEKPQVDIQSLLKDEINKIKAEIITELKMQKQENKSNEKPEDSKIDLQELKRLLSENPKILNKSNEKPSDTLKTPQQDNNTSKKALSEDIGSSKTNSDTKVLENRKFISDQQKLDTIPNIEILKPNESVKNDKEKPDLNKPGNKVTENPKSEILKNDKEKFDPNKPENKPADISKNVISEEKQKQPTKENEQKDSPSNPDQNKENPKNPPQESLLARFGNTENNKNTSTNAEKISKPKIPDEFPSKKDSKPSTNTITKEKDKSTDVQPEFKQPNQSKDEPANTKPSSTSDINSSKKPEVKILNEPQPNTKSPDTTKTPSPEDKHFDISFPPEPKPQKPSGNPFSLSESPNTNNKPNENTKEPQIPTEHSISPPTSPPTNNKSNENTKEPQKSLEPAMPPPTNNKPNESYFLGNTYKDPTSQNTNTPNPDNSPHPPNTKEPIKCQSNKLFTCLDNSNYTFIISPDMIKKIYENYFPKNGKSPDKPKTTSEDENTKNLKNGRDDIGNGTKDGKESKDGNEDKKDKESKDGKESKDGKESKDGNEDKKGKESKDGKESKDGKESKIGKESKDDNEDKKDKESKDGKEIKDGKEIKDGKEEDNKEKESPKEPPKETSKEASKEPQNKESKQISNEPKDKDTPKDKDTPKDKNTPKDKDTPKDKDTSKDKDTSKDKDTSKDKDIPKDKEISKDKETTKQSSSLCPQTKPSLLEIFKVPSHQKDQKPISSQKYKLLETEIFPDMNYEIIISTNSKNKDIKDIDSNNTKADNKDSKDNNNKDILDSNKDNNKEDIEIDQPVFYGSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V6</accession>
    <name>A0A4Q9M1V6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0125p0030</name>
        <name evidence="8" type="ORF">CWI38_0166p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000125">
        <property type="protein sequence ID" value="TBU04521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000166">
        <property type="protein sequence ID" value="TBU19948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0125p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0166p0050"/>
    <dbReference type="OrthoDB" id="2196075at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU04521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="417" mass="47510" checksum="56776F3F3E2E266E" modified="2019-07-31" version="1">MNRTFVVKRRFNDAWAFFLFLASTIGVITYLLVGTEVKSQMEFNFDMGFALITLLYIVICISTMIGSFLFFPAFAMHFGCLVSPLLFLAIAVLTNNIIVIIFAIIGAVIGYLMYFLFYRKNIKYSAKVLKATTRIICKNILTILGMYSILFVLVMGIDILFDRKIILEKLQPLFYAIVILYGSWLFFNSIYFLRVCISTIVCMEIFKETQDSSIAKESVKNTLFCLGSICFGGLIIAVVHTMKHLVQKSNDRGERENILTVILKVLITLILTILEDIISFANDWCFCYMAVKGESYAKSMKSAFEKLTSSRNQILLNSLCTLPIIALFEFMWIAIYIAIFILYNGYHFENTIAKLKDRFIIFSIVSVLYTTMNFGTMFDSGCKAFLFAYSENPSAVAKEYPKVHTALVEQKRKAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C6</accession>
    <name>A0A4Q9M2C6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0190p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000190">
        <property type="protein sequence ID" value="TBU19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0190p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26186" checksum="4DBA86BFB58AE191" modified="2019-07-31" version="1">MSDTSNYVSFWRTKKFRIAAITVSGLIVMIFVILGIGYNKATSIIKDFEMDLKKVSGSERFKKCVSQFKKTKTSAFGLEDESSCFVILPSFDISGIANILFDGFEEMKAGKVLGSTSLFVSETDLSKFPKVVGNVNFLTKIGFWFKGKHAIKAVYELSNYIYKELKNNKKNKSILVEIITEKESVLSSIEYDEKSKGSSKKILFEPLKIENDSFNVSEFIIFIAEKVRNSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2V5</accession>
    <name>A0A4Q9M2V5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0148p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2V5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="367" mass="44425" checksum="A2A4638D126572B5" modified="2019-07-31" version="1">MRISLRTEEQISKYLETFVPKKRNIKILFKRILNQKLKNNSILKFIIYLQKTGIYKKYVTKYLIKNYYIFDISGLYLCSEEEKVRKVFCNYNISKTIYSFKNFLFDEQFYLFGNNFEYFDDPKSPFLLDLYGICQQIPQTEDSWTLTLTTPEHLMCLVRNVNFKNLLLFKLWYYKIEVEKPDEIFKNFIEIDQLWKTWRKIGFPKQEELLKYKEICKFEENDKENEGDNRRDEEGIDRRGKETRIEENEGDNRRGEEGIDRRGKESRIEEGNKERGKETKIEEGNKERDKEGRIEENEDKIVEEEHKIIYQILPPNTSLINNEEDQTSDSEERESKDLYLKRMYIFTPQNERPNVSNEDLSRRKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M305</accession>
    <name>A0A4Q9M305_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0076p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M305"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24591" checksum="E40905DCA712EEE3" modified="2019-07-31" version="1" fragment="single">EILDNEYAEIRVDTRIKTDVKIRNNRPDILILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGINAEESWERASMGMHEEPIPPLKEAKTEEDGAKNFKTKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M330</accession>
    <name>A0A4Q9M330_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0174p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="11965" checksum="F026D6489449046A" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEERWERASMGVIMRAEMHEELTPPLKGEKREEDDAKNFKPKNKATFILQGGTTLAEPTDNINEESAWKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H1</accession>
    <name>A0A4Q9M3H1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0050p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="57792" checksum="95F46508C1A48E38" modified="2019-07-31" version="1">MGECFEDEINVLFESDSKEMPIYSYKKYGKLLRIESSIIEKYKKEKRPYYNIDCIYYYYIHNNRVIKNVFKDIFIRIFQIGILIILIKIFNIDSAIKSKFMVKMVKIILFIFQTIVSVVELVEYYRKFMMFYTGYVYFKYILKIKPNHGFKKILKNIIHIEKKINNIDLTEEEIRRMLLRKYYFYRKFVTNSVFKNVFYKNIFYTKFFKNIVQILVSKNEMSKSRNDKIDIHYLTSLKKRFILFSFILLVISPVILIYNFIFYFVKILRKTLNNSNYLIEKKLICKFEEKESYNQKLYHEKKNKIKRKKIIYKKWVNQRYEYKYECLYYFVSNFLQLFVIFYMYDLIRCLFLYINEFHPNVNKQTAIFGNYISDRLLLRFLFLILTIFATNRLKNLYEKQKINKYSKKSKRFDSSKYMFRFNLVILFVELIAPIIVPLLMLIIFLKKEQYNAFLQEYLNYTYKANINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4L6</accession>
    <name>A0A4Q9M4L6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4L6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0210"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="446" mass="53290" checksum="7DC4FBEA56788086" modified="2019-07-31" version="1">MLKIIWIKLVAKQICSQKIIVLFVSVFLNASFQADNHLILHFYEPPVYKESDLPCDKENGRFFSRYVKKKYKCFRHNECIDCKKITIEKNIDLKLNLKSLDGDITDNSIYLNTNVLKYNELLYFFNLCRDSSEIKENFETKNFSLILRILDILKFKKDKNFLEFIRILLLSVILNAQSSSQRYNLDKESIISSSLLHIFLGEFGKIYLFETNLFKEYLSDKTIKEIFDNNFNMNYRINTKFVHINSCFIVRLDKYIRYNLCCKEAFMIFFNCIRISSMIMVCFEETLKNISFDISKLIFSYVEEICFHSRESMKYFEYLCDSMFFTHIKILVLIYCNFYIFSETIFENFKSLECIYLVDSYSINLNLQSMIYSYLRNLLYMFYDDISSDKNASSFFEIGTEKYDKPESINDECIVGTKTPFMISREIKDKENYMISHNMIIYVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5C5</accession>
    <name>A0A4Q9M5C5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0022p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5C5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5C5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0010"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="6">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="24431" checksum="FCF8D8513A496032" modified="2019-07-31" version="1">MENQSTIARFIQSGIKYAEINEFLSKELREEGFSSMSMNSYNLPIQITIRALKTHEIAGDKKTRIKALQSVIAQRLNVQETDVVIALESVQNKGLCPFIQADSIRQKIQANIPFKRAVNGAIRTIKEAGAQGVMVVVSGKLKGQRAKSVKFSDGVLLHSGQPCEDYVRKGFTSILLKTGVIGIKVYIMLPYDKDNINGPNKEMVDKIRVFDTKDEMIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5I3</accession>
    <name>A0A4Q9M5I3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0020p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000020">
        <property type="protein sequence ID" value="TBU20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5I3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0020p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25286" checksum="F174E0FE0E00E2CA" modified="2019-07-31" version="1">MLIKGEFKEIKFYVNSDIDSVNYKNKKEVESFKINVSDNDYRGSSKEGEGSRGGSDNKGSMEEGKEEVDNNYKGNNKGNEVDNKGNEVDNNKGKNININKGNNSINTPSNTSGNQDVDCFGINNVHINEIVLRNSKYKDCISISLLLNGNENSKLYYLSFKGEKGNEMAKAVVTKYEARSYEDITCKDKGDKDSRLKVGGVSDKDSRLEGNRLGYDEDSRLEGNRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX22</accession>
    <name>A0A4V2JX22_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import receptor subunit TOM70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2056p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002056">
        <property type="protein sequence ID" value="TBU10062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX22"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2056p0010"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="57089" checksum="8D632A6E78F397F9" modified="2019-07-31" version="1">MSKKSIGAIITAGIALVGTSFIFYNKIKQRRKQRNIERSSGLKQEGNILFKHNKIEEALQLYLEAESLLEEDNIERVFIYNNISTCYFLLQDYKNSLIFSSKTLRIDNKNLKALRIYMETNIKLNNTDEALFYSFVLSVVSKYRNDKNSDKSKSIANSLLNEKTRIETIEYLKIKRDFLPFTVLNDFFSKIKNLENFVSDEKDNLIMKLLDSKEYKELIVFEGNTELIMFVKGGIEFCRGNIEQAKEYFSQNNFLYSVIMLEYINSDDPEYKYSNILDEIISNECNDVFILCYAALIFTKIKDFGKSNEMLEKAELIDSNYHFIFLVKIYNLMSNESTGEMVYKLLEKCRNEFFDKVDLMSVVCDVYLQFSDYNSAIELVKEMMKRFSDDPRPYIYMGLLHEVSSKNELAMQNYLKAIEVDSTFCKSYILYAKSLLMVYDKKCRSWFENALNIATSFEEIYEIKQNLLLMQIEERISALYPELNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX61</accession>
    <name>A0A4V2JX61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1685p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001685">
        <property type="protein sequence ID" value="TBU10552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX61"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1685p0020"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="22760" checksum="6E10B81B185B1532" modified="2019-07-31" version="1">MARPRSHKRSKNPKRPYDRDRLLEEMKFVGMFGLKNKRELWTIQKICDDIKRRARDLLISNDEKQQIVDGRCLLNKIVKIGIFEDVDFRDRSDIVKNLEKVLNLTPVNFLERRLQHRVFEAGLSKSVHQARVMINQRHISIKGRITDKPGYIVSAENEGFIEIAPFSSLGGNKLSKRKKKNRGHTGHQEELTAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ6</accession>
    <name>A0A4V2JXJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0011p0060</name>
        <name evidence="3" type="ORF">CWI38_0746p0040</name>
        <name evidence="2" type="ORF">CWI38_0957p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000957">
        <property type="protein sequence ID" value="TBU11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000746">
        <property type="protein sequence ID" value="TBU12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0746p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0957p0020"/>
    <dbReference type="OrthoDB" id="2195889at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="190" mass="22161" checksum="C52C3CE5972BFB4B" modified="2019-07-31" version="1">MQEKLQKLNLLFQEIKCKLTKIQNITTDLKHFNTKMNALLQALDAYSSEDKQAEILLPENLDVSVERLELSTSNIDFTSLNNNISFSECLYDSKKEKSTIKQQITKKSTLEEIWTEIILFLPDNKLYRTNAYKIVKCLYENRNGLTVEIIIKNTGVAKYRCIDTLNHLIKNDPPFVKKVFEKAFIYMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP6</accession>
    <name>A0A4V2JXP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0700p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000700">
        <property type="protein sequence ID" value="TBU12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0700p0030"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41202" checksum="9C7BEC5F00BB240D" modified="2019-07-31" version="1">MENVKENLLNSEKRDSKYKQLTKEQRQGILEKLLQQIKENKLKHGAINEVLLTFNLSFAIDIPKSTMFDIFKSGWYIKKISSTVKPTLTDKNKMDRLLFCLSKVNLTKNGDLLFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEENPEKNCKSKRFITKIMFMAAVARPRHDAHRKLYFDWKIGIWPFVYKEPAQRNSKNRAKVTMIAKNLESVTAVYCKNMIIINVIPAIKSKFLPAYKRKTIYVQQYNEKPHFSKNDPDIVALGSADDWNIKFKAQSANSFDLNVLGLTLPHSIDELINCVQDAFHQLEANTLDNVFTTLQACIESIMLADGGNGYKIPHLSKGKLRREDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW7</accession>
    <name>A0A4V2JXW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0442p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000442">
        <property type="protein sequence ID" value="TBU13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0442p0020"/>
    <dbReference type="OrthoDB" id="8195170at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21206" checksum="B8912D9E5479B519" modified="2019-07-31" version="1">MNAKIGKEVTCGSIGNYSLHKEHSENGTWTAPYGGKVNQIDQILIDKRQSSGLLDFRVHNSANADTSQQEYHTPEIKKEPSLSEKAPVLTKEMDGLMKNILEDFEPREVMKRSMMTQIKRIRKYNTRHKTAVEVKQSEHIRELLGECKDQADIDKVFDKPGNTGSYKDIVLSYEEVYKAMEKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX6</accession>
    <name>A0A4V2JXX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0411p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000411">
        <property type="protein sequence ID" value="TBU13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0411p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="51446" checksum="609776185BD8B350" modified="2019-07-31" version="1">MFINNERFLFFILENLVSVDNNLKNCLIFDKKNKQVEFCIKFYRDCHHNLQCKTYLKTMIFYLKYLNIKCLNFNPFLSPEKEYMGKSISDCNLKKYNHNFIFKDADFLMFQFQKINDLKIFKCDIVTVTSLLNHFKILRSLYIQNDIKESLDEEITFDFSILEKFKDTLKIIEIRYYHCFTNKDDINFSQLTMIRIHSKYRPNFEQNHINFLNKMVSNKRISDLHIQLCGIKIYKLIETLYDLNHLTSLTLLKLDLNESWGLYYLKNLENLELDISTLNYRKKFKNKEANKLKSLKIYFNQYFFADKISFFTKFLWEYNLPNNIVLTTSDTKNNFIDISSYEFHSLLKEVEFCKFIGFNIICRDVDLFKIKLEKMKNPKTLIFEECIIDLSSIYFFYLKKNDSLKIISYMSTYSMNYENNKKKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY18</accession>
    <name>A0A4V2JY18_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0300p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000300">
        <property type="protein sequence ID" value="TBU15978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY18"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0300p0010"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="272"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU15978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="672" mass="77217" checksum="445C56B1F6415121" modified="2019-07-31" version="1">MSKDIEITFDSKTYIYPPGVTPFKISKEYNPEHPKVLVAQSEEKLLPLSTPLFQNTKIKFLTFDDAEGKKVFYHSSAHVLGYAILQIYPNAKLSAGPPTAQGFYYDVLLDKNHTFSTNDYLQIDNKMKEIISKKTPIEQKFFKREDLLEKYKENIFKKHFIDEAIKKCKEDELLSAYCINDFVDLCPGPHILFTNNIKIIKVTNHGSAYFLKTKISLTRIHGVSFPSLQHFDEYNRNIVKAKKRDHRNSDLFFVSRFSPGSPFFTVSGTFTYNSLLNYIREEYKKRGYGEIITPVIYSNELWETSGHLQNYKENMFLLSVNGGDSVSKEVDEANNCGELNGQSDGSNCHNNYALKPMNCPAHCLYFRQTDRSYRDLPLRLADFGVLHRNELSGTLTGLTRVRKFSQDDSHIFCMLQQVEGEIRGVLDFLDCVYSILKFSYDLKLSTRPEKFIGNISDWDEAENMLIRALEGRDYTINEGDGAFYGPKIDIVLYDGYGRQHQCATIQLDFQLPIRFNLKYRSKEGKMESPVMIHRAILGSVERMMAVLIEHFDKLPFWLNYRQTCIISVVKSENVNNMQSESSSSKILSYCDSIKENLSEFHVFVDDSDLSVSKKVLRAETSHYSVICIVGDKEVQEASVNIRGHGMVKLEKLKEILTVMLKRKIELNDAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY86</accession>
    <name>A0A4V2JY86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0126p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000126">
        <property type="protein sequence ID" value="TBU20143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY86"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0126p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21619" checksum="7FAF718DACD404EC" modified="2019-07-31" version="1">MALCLRKEMLNKNSIPRIIIEFLFLAAVLKKEFETDENVKNIKIYRKKCVVELKKKVNIQNIKYVDNTNGDYLNRNKVPETSLLLEIYCFLKLFSNDSFKTYLDKQINQKPNVEVDAINIDKDVNLLDYLKYVFQNEIFVLSLEEIKLVFGTPVSEGTEPKPESKNSNISYLHSLLFKYYCLPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY88</accession>
    <name>A0A4V2JY88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0119p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7915" checksum="72A936EAECDD27D4" modified="2019-07-31" version="1">MIYERALIWKIETRHLNNKINLNKKCKQTSSKRLRIYNSEQQTANKCKKLKESHRFRKNSHRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD6</accession>
    <name>A0A4V2JYD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0027p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18628" checksum="8627C6C02E1F384B" modified="2019-07-31" version="1">MLLNLIHLKSLFDVEKNNIRVFIRDFSHSSFLLFLKLIDNLDIIINQIKKQTFLDILIIISILDIKKSKERNELIKELLRSLLYGINRVSFDFDLDNEYINFFNYNIKRSIMRDLLVFFLELVYFEEKTTRLYILIKKGNNVSFGKNLCLSYENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF2</accession>
    <name>A0A4V2JYF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0011p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8669" checksum="934FBD89D93D9B12" modified="2019-07-31" version="1">MDAKAYIQMSMCVIKRAEIPNEPTPSLKQANRNEDRRKFKKKNITPFISERGTTFGEPRLKLIRVGFRRRNDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KU61</accession>
    <name>A0A4Q9KU61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1899p0010</name>
        <name evidence="2" type="ORF">CWI38_0298p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001899">
        <property type="protein sequence ID" value="TBT98115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000298">
        <property type="protein sequence ID" value="TBU16192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KU61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1899p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0298p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU16192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="167" mass="19674" checksum="37AA0DB1C631B24D" modified="2019-07-31" version="1">MFVKNTIKILIRNNTFIVPSIIKIKKLKEYIDECEKRELKNGKLMDLQKIISFILYSNMFTKLKNGFQNQTVAHLKETEPMTFTFSSIENKLMDKHIHPMYFLLFLNSKLEVNDMQEPAFEIFNSISPISKFFLYEVISDGISAFFSLFSTKILRILKESQKKLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KW73</accession>
    <name>A0A4Q9KW73_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1456p0010</name>
        <name evidence="4" type="ORF">CWI38_1806p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001456">
        <property type="protein sequence ID" value="TBT99126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001806">
        <property type="protein sequence ID" value="TBU10379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KW73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1456p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1806p0010"/>
    <dbReference type="OrthoDB" id="2194424at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT99126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="204" mass="23388" checksum="30D8D6391749B1B3" modified="2019-07-31" version="1">MRSTENITDEDILKQLKNQGFSEEISKMALKNCKSKDIESILEYIEDIQNMEEERRRRQNASVKNEAANQIARAQLEENARKTREQMLKDKLYVQNLKAKIEADRREMQSNVENTAETTTKCSEYEGGDSPCKINVRFETGYTRIFGFNTGDTLENLFARIGIEMSGTVFRVFRTGTSEEIFNDGRTLEETGLSPRGSVMVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWX8</accession>
    <name>A0A4Q9KWX8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1347p0030</name>
        <name evidence="3" type="ORF">CWI38_0008p0160</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001347">
        <property type="protein sequence ID" value="TBT99432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KWX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1347p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0160"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="157" mass="18416" checksum="B84B55FBE7E554D2" modified="2019-07-31" version="1">MATVGNESILEPDSEEEEYVYKLSDINNEIIEKFKNNPLSRSEHIFPKESLLSQVLPSCYTEFAPISPKIELLHEETLFYIFYSFNDENLRLQAFNTLIKKNYLYSSKINCFVLATKNIPDNSKKNILIFDPLKWEKVMKEIIYDEEFVNSLKASIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXR3</accession>
    <name>A0A4Q9KXR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1229p0020</name>
        <name evidence="2" type="ORF">CWI38_1812p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001229">
        <property type="protein sequence ID" value="TBT99748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001812">
        <property type="protein sequence ID" value="TBU10375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1229p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1812p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="161" mass="19355" checksum="DE5C74D68640359B" modified="2019-07-31" version="1">MDSDFLNTLIISYSNVISEVKEIKTNLDQKFNVTNNEILIKLNELDFKIHKVKECFDFYKYKLDNINDCKNTSENQEKISSNSKKRKRQINKNFLSVNKNFIERKKHIKDFKNEINNQNNQEIENLNYNCDFIQEIQEESQIESYSYSEPFIIKSKNYILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0S0</accession>
    <name>A0A4Q9L0S0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5097 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1104p0010</name>
        <name evidence="7" type="ORF">CWI38_0556p0040</name>
        <name evidence="6" type="ORF">CWI38_1427p0030</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001104">
        <property type="protein sequence ID" value="TBU00120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001427">
        <property type="protein sequence ID" value="TBU11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000556">
        <property type="protein sequence ID" value="TBU13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0S0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1104p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0556p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1427p0030"/>
    <dbReference type="OrthoDB" id="2196404at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031511">
        <property type="entry name" value="DUF5097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17020">
        <property type="entry name" value="DUF5097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="4">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="386"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU00120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="511" mass="59835" checksum="375ADD2A2F8A7E80" modified="2019-07-31" version="1">MIESISIKKYIAQYFLENSVQPITETVNQIVQTLSANFINDETVFVKSKEMTGRILSSYQGTYIVGLHYENKMETDKILYKDLMRRDQITKNEVMNYLQNITNETPFGRILKPNILSDLSQRNKSNTNNLKKTPQTTEYREQIKKHQSRIRFPKQAINKKSPIPAPQVVEQLKIEKPKRILVDLMNNTDSFFKSLNGKELDICGFKGENVGLLLEIFSFFNFFGDQISVPSFTIEELASSFSEAEYESKIIFLIHSKLLKILVNERKKHGRDCIKTYIEGALDICKIETDAAAPNSGGFKRIQWFSGDMTHSNWKTYIKSFIFDVNEVYGLQKIMSFKEFSLEKRRKSQSMEFSVKDRLLFVKFLIECVIFSNTVRDIVSKVLDKLKSLEKEKYELSVNVRKHRNDFKEIKTEEEKIKMTEKIDEISERLKDLDVEILETRYRADLGSYKGAKFYRIEKKIFYFYESTYYLLDYAGLSMFLRRIKPGNRTETILSSGLRHIQEVLLLAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L272</accession>
    <name>A0A4Q9L272_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0850p0020</name>
        <name evidence="11" type="ORF">CWI38_0823p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000850">
        <property type="protein sequence ID" value="TBU00951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000823">
        <property type="protein sequence ID" value="TBU12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L272"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L272"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0850p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0823p0020"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="157"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU00951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="377" mass="42406" checksum="3B185829CED683CC" modified="2019-07-31" version="1">MEFFSKQKELDFLKMEEEHLIQEIDHLKSVSNDVNNELDKLRSVPLIMGQFVEAVGENYAIVSSTTGSLYYVRISSIVDKSLLKPNTAVILHKHSSAIVGILPPETDSAILVVDQSEKPDVTYADIGGLDVQKQEIREAVELPLLQLDLYKQIGIEPPRGVLLYGPPGTGKTMLVKAVANQTKATFIRVNGSEFVQKYLGEGPRMVRDVFRMAREKAPSIVFIDEVDSIATRRFDAATSADREVQRVLLELLNQMDGFDQDTDVKVIMATNRIDTIDPALLRPGRLDRKIEFPLPDRRQKRLVYNAITSKMSLNENVNLEAFINLPDKLSAAEIHSICQEAGMLAIRNGRYMVIQKDFEEAFTRIISSKADVPLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L319</accession>
    <name>A0A4Q9L319_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0607p0020</name>
        <name evidence="10" type="ORF">CWI38_0065p0080</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000607">
        <property type="protein sequence ID" value="TBU01883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L319"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L319"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0607p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0080"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU01883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="326" mass="36719" checksum="940991754D796C24" modified="2019-07-31" version="1">MDIEWKNVDIELINKNKTKNTKYVKLVTNANGIVKAGSLCATMGPSGSGKTTLIKALVGRIPSGSKTSGEILASGQPRNYKCWSKTVGYVDQDDCIFEELDVKQTITFAAKFRLKDSSIDIDKKVENILEELDILDISGSKMNSISGGERKRVMIAIELVTEPKILFIDEPTSGLDSSTAYSFVNLMKKLSTTHKMSVIFTIHQPSGEIFNIFDQLILLSDSNQSEEYFTSYGLIKRESSTFPDFLAEVLKVKKKYREIPENQEQINKIIAEYNKKYPKSSKMQASNKNTISVGYLPNLLHIFILLHRRIKINISIKRIISTLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3H2</accession>
    <name>A0A4Q9L3H2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_0647p0020</name>
        <name evidence="15" type="ORF">CWI38_0229p0030</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="PITJ01000647">
        <property type="protein sequence ID" value="TBU01706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000229">
        <property type="protein sequence ID" value="TBU18744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3H2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0647p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0229p0030"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU01706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU18744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="338" mass="41172" checksum="B4BD69813BF72089" modified="2019-07-31" version="1">MDYQRTFNSEDDKYFPFGKNGDVINYKDNFEYKELCKIYYFLKTTNMNSTSLLGITSKLCEINMIYYEFWYVKRKIVTKMFEEYRKIGSENRNNYLTEYERISLWKKKKKIFFLFELTRDLRLDYTDAEMNWIQKCVQIHHKNYQIWNHLDWFSIYRCITPSNLSFVNNVFKEEPKNIHAWTFITKYCRKSKSYTFGLDLTEKMIVLDQENNSAWNCRFYIIKELNSLKYDVLETEISFLKSINFSCNIAAINYLFGLTHFLDIDAFIFNTFKPIYSLYFKKKFFNFIFKERKSDFPDSLKILLQECISMCQEEAKRYQKEFLEAEIEVFSKNTKIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9U6</accession>
    <name>A0A4Q9L9U6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Subunit 11 of integrator complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0167p0030</name>
        <name evidence="13" type="ORF">CWI38_0109p0060</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000167">
        <property type="protein sequence ID" value="TBU04226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000109">
        <property type="protein sequence ID" value="TBU20229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9U6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9U6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0167p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0109p0060"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="11">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU04226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="500" mass="57307" checksum="40DDB610F0569BA7" modified="2019-07-31" version="1">MQIIPLGAGQDVGRSCIIVYIEDKTIMFDCGMHMGYSDARRFPDFSYLSSTNSFDKAIDCLIISHFHLDHCGALPYFTEVLGYNGPIFMTHPTKAICPILLEDYRKITAKINDNKHFTSSDIKNCMNKVIPLNMNETYVHDGIEIVPYYAGHVLGAAMFYVKVKDESVVYTGDYNTTPDRHLGAAWIDCLKPDVLITESTYACVIRECRKAKEREFINCIDETIKRGGKVLVPIFALGRAQELCLLVDAYWEKMGYSTPVYFSAGLTEKANQIYRLFINYTNENIREKIFQRNMFDFKHIKPFQKHFLEKNVPMVIFASPGMLHSGLSLSIFKEWCNDEKNLIIIPGYCVKGTVGEKILNGCKEIKINNEIYEVKIEVKNLGFSAHADEKGILQIINQCKPRNVVLVHGEKSKMKRIQKTLQNLGITAYKPANGIRLNIERSDNLKLRINKNLLQSFVHLNKSEENVNLKLKISMEKEVSKKILKVTECEKYIFDNRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFJ1</accession>
    <name>A0A4Q9LFJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2685p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002685">
        <property type="protein sequence ID" value="TBU05891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2685p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10657" checksum="5CC7C09225C63366" modified="2019-07-31" version="1" fragment="single">ANQLGLIYKCNVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVKAYIQSIVIKKTEPTPSLKEEKREENGAKNFKPKNKAPFISQGGTTLRTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGC5</accession>
    <name>A0A4Q9LGC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2618p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002618">
        <property type="protein sequence ID" value="TBU06211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2618p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020903009" evidence="1">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="22808" checksum="882FB905B402DE11" modified="2019-07-31" version="1" fragment="single">LLYVITIIGTFDYVFGASNSQCWAKKKYYGRKSSSSSSDDSKCCKSRSCSGHKIQEKRIPCDSRHLSFDEACRNHLKKSFLLDEREHVHSEFSCGFKEPGVSVCRSKGDTGKRLKNLNERVKLENIRLDNCRDRITNIRNIKIKSKCVKNIQKIGNSIRALSHSIRADGLNSSDIFDLELEADSIESSILGLENYLTIHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGT4</accession>
    <name>A0A4Q9LGT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2588p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002588">
        <property type="protein sequence ID" value="TBU06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2588p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="222" mass="27034" checksum="82F51CD8B8D23DD4" modified="2019-07-31" version="1" fragment="single">MVVSDINEERVVNIVLIFFLKAWWYKNLKNMYLYKAFRLHYLIYNILENSINCTLHRINIVYVSKNELKLEEFEKYKSIESNLKQSVYLNNSFTNLRVKALEIIYKKNLDKYKELNKIEKCKIIIDYPHQCLLKFKTFDTFLNSKTKSFNLYLDELDNGSLNIFIKSLSRIDYFVNNIKPKLFYSILFWLQYFDVIRNKYFEIYLMGLFNNSLMGQYSNEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGW1</accession>
    <name>A0A4Q9LGW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2413p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002413">
        <property type="protein sequence ID" value="TBU07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2413p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="84" mass="9025" checksum="723CAD8270BEB295" modified="2019-07-31" version="1" fragment="single">MKHICNGKGVIKGMVRGVRDKDSKEGGVSNSSSYKDSKEGVDKDSKEGGVSNKDSKECISNSIHDYKGVSYIINSNEINGSIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNL5</accession>
    <name>A0A4Q9LNL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2076p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002076">
        <property type="protein sequence ID" value="TBU09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2076p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="8699" checksum="38E6FDAFAE0414D9" modified="2019-07-31" version="1" fragment="single">ILLKKTVETISFDRRRGLESGPNAEESLERASLIDNEEDDVKTKNTKNILLLILDGITTAKEPTTNTNEELELEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPM1</accession>
    <name>A0A4Q9LPM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2162p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002162">
        <property type="protein sequence ID" value="TBU09310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2162p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="115" mass="13335" checksum="247EEE2768509822" modified="2019-07-31" version="1">MTWDGIVTKYHKTYVKRLQISMNVEAYIQSIVLKKTLETISFDRRRGLESKPNAEESWVRVLMGVIMLAEMNEEPHLLQNKELDNEEYDAKTENTKNILPLISDGINNHSKATNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPY5</accession>
    <name>A0A4Q9LPY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1890p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001890">
        <property type="protein sequence ID" value="TBU10267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1890p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="20906" checksum="45303A81A2EA726E" modified="2019-07-31" version="1">MKKDHNIAKGHVLLIHYYYNIIKILGNLIFGNNQEANKEKHEEKRYEVAALIQKRIFFMRKLLSELFILFQNYINKAHILEKNHYILKMRFFFRFPFDLDSKPNNIFLAEIIHEIYFKNMSYHVEIYFQQKLTALFYEYYCINIYFDNVLAIIDSYKIYNNLLKFLELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ09</accession>
    <name>A0A4Q9LQ09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1756p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001756">
        <property type="protein sequence ID" value="TBU10444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1756p0020"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17851" checksum="9FFFD183A46AF0C6" modified="2019-07-31" version="1" fragment="single">DLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKQKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE7</accession>
    <name>A0A4Q9LQE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1567p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001567">
        <property type="protein sequence ID" value="TBU10753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1567p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="491" mass="58169" checksum="5447C233A5E181F8" modified="2019-07-31" version="1">MYFYPVPQMCYYNAALLCNNPEFGIAGYILLNKTQPTNIIPVSAVQYNTGLTNIAYNYAYKSDFSRKLLARNNKFKHIASRLEYEVVNAYDACICKTNQYAVFEILQRVCSKDEIYELEYFFPLLENDYDIFLKDIICHINDVFDLTENIKLSVNKLFHSRKLKGNISSELLERFKNNIMILFKTRGMPMIYLKPIFLILPIWIKNTLCNDSNLVNNVLYIPWCLKVIKAIMEYNYDVLKPFIFVDYEGNGQNEFSYIFLKNQSNISYSFSLISRMLKNICITLGKESIYTIFESISKVDFLYSHYDRVFSPEYICSGMPGMLFDVFVLLPTESMIFLASMVSNHDSLKQKPGNKDIDIKRYIRAQITVESYKRNKSIQHLFNDLTLTYKRILCDEITLNYFAKDRRISNNNFKKWILENINNLEKMISYDKLPKYVNYIQFIKTSNLFLHYVSKVFMNPGLTSRRFKDIITRKMIWRLNYFYFKQTSAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH0</accession>
    <name>A0A4Q9LQH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1653p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001653">
        <property type="protein sequence ID" value="TBU10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1653p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="484" mass="58030" checksum="E817600FFE9FF8FA" modified="2019-07-31" version="1" fragment="single">RKEELKNESKESSSHNFNRKVTKRKRKEEKIRKKVKIDIDDEYVCRILEFKEKYKKSQKKAFLEANIPYIKRKVEPLSKKKIEGSFVQKKIQKLKRLASIENRNLTNEEIAFVLENSSLLVDDSVSPTQALKIGKIVNYIKNYENKYKPSFTERYRIKIDEPLDRRGIFLDYYQEILEREKKEEKIEEENKKVIFRDQIQFFDELQENDRDSQFNIQLGTNQTDEEIYGIPTYKNTSITHNSINFLEKPSQPFSKYSFFPENISEEKSKIQTQNFTSTEPTEQYNDQTISKNIKEIQNFIKNEGQNEIPYYTKMRPDKSQELVESKNEIPYYTKMRPDKSQELVESENEIPYYTKMRPNELQEFRERENKIEKLKKEISPNLLKELDSIYELIDSPIFSYLPENIHYKDKDIMYYKDDVSYGILPYEYRHLQNLPPVILKKALDPNNTDPSIPFIHLGKVTAEEEEKYFSENNLKKIMKKEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH6</accession>
    <name>A0A4Q9LQH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1577p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001577">
        <property type="protein sequence ID" value="TBU10739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1577p0010"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="21137" checksum="0EADB772A435BA98" modified="2019-07-31" version="1">MFTVDLMSPKDIFALDLANLDYKTDNYGFQYYLYYLLNHDSDCFSVHLYNTEEPKDLPNEYFKYTKNVSAYLIGKHEMDDNLLKGHVTALSVAPQYRRYNLATILMNFLELNGTFCNAYFVDLFVRISNTPAISFYSKNFYKVYRKINNYYSDPLEDGFDMRKSLPMDKEGKCCIPKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT2</accession>
    <name>A0A4Q9LQT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2081p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002081">
        <property type="protein sequence ID" value="TBU09971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2081p0010"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="125"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="319"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1106" mass="130470" checksum="D76C77622B69C44B" modified="2019-07-31" version="1">MEDLIEKFSKKFKITKMETKNLIRQSLLQNNYEEEVSNLIGYENMDSIIYICKNRDLFLNTKKEESEFIWPGEEKQTSKYLEYILPTKKSIEINIEELICVSEVGTDHKYFDFDYFNPVQTHVFETAYKTDRNFLVCAPTGAGKTDIALLAILKALKSKNAKIIYIVPMKALATEITRKFQEKLRNHVVSEYTGDTDLTRKDLEVSDILICTPEKFDVSTRKLDNILCSSISLIIIDEIHILQDDRGPVIEAIVARIFRFIVLNQKNIRIVGISATLPNYKDVAHFIRAEDVFNFTNEYRPVPLRISIVGIHKQKNNSNIEDTMIELIIEKMNKLSLEKQQLIIFVHSRSETVRTVKKIIKELFNEDFNDRKYNIQNDRKTNKNDKKMTPLLQEFIYKGFGVHHAGLPRNIRLEMESLFRNKKIDVLVSTSTLAWGVNLPAHAVIIKGTTFYDSDRGSFTDLGILDILQIFGRAGRPQYDTYGEAFLFTSSDKLSFYLPQLKNQNLIESNFLKSTVDLLNAEISLGNVNNIEDAIKWIKGTFMYVRMLKNPICYGITQKEYEEGNILNCITEYIVLAAKKLKESKMIEISVSDSTNFINLYSWSFKSTFYGRIASYFYISSETMKEWLEKTDFLFDEESIIRLMLNAKEFSSVILRQDEIFTLKGICTDLNIEYEESERCKLYTLAYCYIKNIPIFHFSLTCDSNFIAKNLQRLSLALERIFLFQNNFILFEKLFFITKKIFKIVKKNEKHEFRVSNIRIGRYLKINIEMDILDKVAIFIYKDPFKDDELIFSDYFSRKTEIFVECNVNEIKIRIIGCERWFESTKIVKIENIDSMKEYFKILYHFGYHSCEKVNWSLFDYKKSCKHFSIIYNQNEIMKNIENAKRNQVFITKRKIDYNFKEIKEKNLDFKFFYDNDSNLEVYLKEKTINLNNIIVFTNISSNLHNFEYFKCFLLSNYKINIEPEEVYNENFQEKNKIITSLIFKRSLNIKDNIIIVCANIHECIKTGQELRIKMSTITDTCIKNYDENYGVYWNTKPFKESKIVLLALKEAKVFCKNEIVIFKGLYDGKNELYNFSEIFRLFDERKIIIYENRNFITFFKSLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR33</accession>
    <name>A0A4Q9LR33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1449p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001449">
        <property type="protein sequence ID" value="TBU10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1449p0010"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="228"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="54869" checksum="EB32C89D6606B3C0" modified="2019-07-31" version="1">MIIAMVCDYFFPNIGGIETHIMCLSKELVKRNHKVIIITHSYDNYKDIHYLKVDKYNYIKVYYLSLPLVCQNTTFPSLFSNFKHFFEIFISNEIEIVHGHQSMSNLSIEGVSHAITMGIPTVLTEHSIFETGGIENIIVNKLCEGILKNIGAYICVSYCCKENLIERFEIKKENKIFVIPNGVKSKNFRCKKNRNKIQRQKCGVTNFIHKNSKKIAESFELIKHEDNFKSFFGEFEKRIKIAVVSRLVYRKGVDLLIEIIPMVCSMTKNVDFVIVGNGNKRENMEQMIDDNKLHNRVLMLGELDNKNISGVLQRCQIFLNTSLTESFCMAIIEAVSSGLIVVSTNVGGIHEILPDEMIELRMTSCEDMVEGILKTVKKVEEGEFGCGNCNKLKNINEIFENDKGSLEKLRTNEFFQSKEIIYCKKCSPIRFHKFVKKNYNWKRIARKTENIYINAFKNNELNHADDDYEDYKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB4</accession>
    <name>A0A4Q9LRB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1540p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001540">
        <property type="protein sequence ID" value="TBU10807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1540p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8486" checksum="05C652EA91920042" modified="2019-07-31" version="1">MLKFVKIDLIFIFDKCKKKITFIKAGIKFRDSLQIVETEKLRKYDLLANELDLIYKCPNAEDSWERASMGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC2</accession>
    <name>A0A4Q9LRC2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="4">2.4.1.132</ecNumber>
            <ecNumber evidence="4">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1459p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="4"/>
    <dbReference type="EC" id="2.4.1.257" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001459">
        <property type="protein sequence ID" value="TBU10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1459p0020"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="5">
        <location>
            <begin position="300"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="49815" checksum="CB1E04E54B0F1C45" modified="2019-07-31" version="1">MSKICVIHPNLGIGGAERLMLDICKSLKDEDNEVVLISKNFDEKRCFDDTLDICRPLLVGKFIPDSIGGRGMSFFSLLTAIYISVYVILFVEADIVILDHVPYSVPFLRLFFEKVFFYCHFPDICLKDRVPSLISPILFIYDSILLYLESFCVFFASKILVNSNYTKTVCKSIYGKDLQYFILYPCINDCYIVYDKNNLLGIRKKYDILLTVGRFHPKKMLDISIDVFNESNSKNLLICGGFDSKYNSNHFFELLNKSTEYNFQIHIMDYSCHSIDLKFFSLQNYKNKRFFYHKCHIDEKFDDIFEKYSSSKKVFFVLNCGTKILTHLYSISRIFIYTPEAEHFGIAIIEAMQQEIPVVARKSGGPVEIIGNYENGILVNGSTASFVFEVENLRKDDELYEKVSELSKLRALDFNFANFTKRLIEIIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD2</accession>
    <name>A0A4Q9LRD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1392p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001392">
        <property type="protein sequence ID" value="TBU11089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1392p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21678" checksum="064CA969B39E8C7F" modified="2019-07-31" version="1">MVEFREINNRTRPSENNIPNQNNNNGEDSSDYIYYDCRDISDVERPVSPVSIRRDGFYIIDVENRSSRSRNININRSRIGNVNRNLSQPSLTSSLMTVLRIITARDKSPDFLIFPLLLFIICYFFRISYVPFHLTIFVFYQYLSGNSFISFVTNFFIYYSALFVLKIIKYFIWKTLKWSFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR9</accession>
    <name>A0A4Q9LRR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Anamorsin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_1419p0020</name>
        <name evidence="12" type="ORF">CWI38_1364p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001419">
        <property type="protein sequence ID" value="TBT99218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001364">
        <property type="protein sequence ID" value="TBU11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1419p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1364p0010"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT99218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="118" mass="13487" checksum="8466585018DFFD51" modified="2019-07-31" version="1">MEKNDDKNKESSDELTVEQMQEILSKSIKRVVNNKPDDFLTEEDKTNNNKCDISTTKKKRTCANCTCGRKDEKEFKSKCGSCGLGDAFRCSDCPYKGFPPFKEGEEVFFNMDDNEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU2</accession>
    <name>A0A4Q9LRU2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_1932p0010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="PITK01001932">
        <property type="protein sequence ID" value="TBU10220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1932p0010"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="153"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase epsilon ,catalytic subunit A thumb" evidence="18">
        <location>
            <begin position="944"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1439"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU10220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1471" mass="174121" checksum="3DB6B4F2DDB2BC9B" modified="2019-07-31" version="1" fragment="single">FLSYHDFEERNGWLLNYVVTQDIDTSSRVKFYFVDAQKQNFSISIPFFPSLILETDEINFLEEYLRKKYEGEIECTEIISRMDINIYNHLSLKPGNYLRIYFKNEIFFSKAVKDLKKIISKNKVLHKHETIYEDFSFFKSESQNMNINCNIKEIYEYDIPYEVVISVELNIKCGSWYEIKYEGEKYIINPLLYEVPPELRIFAFDIETTKQPLKFPNAEIDEVMMISILTSNTGTLIVNRLIVSEDISDFEYSPKEDMKSEFKIYNEMNEEALLLRFYEIIQDYKPHVITTYNGNVFDFPFIFKRSLKYDLNMGDIIGFNQTRENFVCNFIVHLDCYKWVKRDSYLPIGSQGLKSVAKAKLNYFPDEMDPELMMFSAKNEPQKLASYSVSDAVATFYLYLKYVHPFIFSLSTLIPLPPHDVIDKGSGTLCESLLIAECMKNEILVPPKKNSDDMLFYKGFLVETMTYVGGHVECLKAGIYRSDFEYDFVLKTNSINKLIEQLEIILKDFRNEEFYEEVIKKIKYKLTEYIINGNKSNETAENNFNQSNNKNVLVNKIKLREKPLIYHLDVAAMYPNIILTNRLQPYSIVTDENCMRCDFNNKNNLCKREMDWVLRVEYLIANKKEIEMLEFQLENEYFKIEENIKPVIYKNLPQKKKNEILKERIKNYSKKIYNKIYKSNVENKSSRVCQREVSFYVDTVRKFRDQRYFYKKKFQNAKTDFENEKSDEKKEILSKMLVVYESLQIAHKCILNSFYGYVMRKGARWYSMEMAAIVCNTGGSIIKEARNFIEGIGIPLELDTDGIWCLIPESFPDTFLVNKNKKISFLCIVLNYLISQKFTNQQYQEKIIINDCNSEITSDNKSSFINTENFLSSNTILNSDQRKFHIKNKYEIKPYNSIEFEIDGPYKAMVLPSSTEEGKQIKKRYVVINMKDKISELKGFESKRRGELKIIKKFQEELFNLFTKGSNLQECYKILGDCCNYWLGIINTKGKYLSDDDIFELFAESKNMSKRLEKYDGRKTTATCTAKRLGDLLGNEILNESGLKCEYVIARYPEKKPITDRAIPVNLFYSIEEVKNKYLNQWLGIHTPIDIRDLLDWNYYFERLETIMQKIVVIPAFFQNISNPIDQLRIPNWVFKNKKNESLKKLNFICDLEETVKDYSIKKVKHKTLEENINFKNKSQNQEFHNKESNSKESLFNIQKEINCKKNENYLDLLKKGYSFYINSIKNYWKDDFFKKNEERKELNNKTNILGIEVLENGTAILHKSINENYISEKIYPEKKLFINLLVENIEDKNFSMEKGDYYIDDSLFTVPLYCLKLLEKDYILKFKLISNFFDHLCVKSVYEEDRDIIYNIYSEYENEAKYFTSCFVLSFHYYGKDSFIFLTENKIYILSKSEYFLKKGIKNKLYDAFNGFESLDDELKVFDLRKEGYDIEKESIINANKNTNEQKNEKPEIENDSEKVGINLKENTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX6</accession>
    <name>A0A4Q9LRX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1291p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001291">
        <property type="protein sequence ID" value="TBU11269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1291p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="41630" checksum="6364EA5AFFAA9EB3" modified="2019-07-31" version="1">MTKISGVKIEEKQIYLLSESQDNESVWVTAKKFSLDIINEYFNKTYAEISQIIKNMNSDISEGIKGDDTDILTDKLTIQDEYEQLANDEVDILGKRDESGRMTLKIKQEQPYTVSSQNIDEEKEFCIESVNSDEEEFLENLSDDFRSFRNRKNVLKNNQTEQSSICNTDTSENISDFNNIKTPFLFGHLSGDSVMSDLTKYGSTNQSTTLSNKEPSIEKTNNYNFNKKKVKTSNSKNSEKVKKVKITSSKENKDIQIYKKNEDSEIDIYDNFIFTRKKNVRNIKFYTGVWFNPNENRKRVSLKFVKIPNKKSILRANQTLFQTGKVKKQIDDSNDIFISRQGKRIDGLSLLGLLEESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS41</accession>
    <name>A0A4Q9LS41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1845p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001845">
        <property type="protein sequence ID" value="TBU10330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1845p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="22487" checksum="52B35085031AADC2" modified="2019-07-31" version="1" fragment="single">NHLNIKEENLLDSDGSLNVEEFLKLNYNCKTYFDICGNTFFEIEMLDNLLDVVTLIVVALSNEKLDVKYVKKQISLSFLVGFMDIVPTKIHKSMYDIFHINAWYFDPIGMATIRILYFDDYKILDNISNLKNAGLEKQIYHTLLLFKKKDGPFTINTENIVILNDTRKNLEMLTSIEYKNLLFFINLFMSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS59</accession>
    <name>A0A4Q9LS59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1696p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001696">
        <property type="protein sequence ID" value="TBU10531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1696p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="14576" checksum="837883A4C3595579" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSELQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA5</accession>
    <name>A0A4Q9LSA5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1770p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001770">
        <property type="protein sequence ID" value="TBU10425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1770p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="94093" checksum="388A1B295E4795E1" modified="2019-07-31" version="1">MIICTIFKKKKFFSTKLFFNLIHILGIFLFTQTVTSSLFTYRLIVNENSEILFFEEERNESLEDKKSKGFFNFNVIFNSIENIITYDRPVFIYRKDSPIQFEVLNNFLVLSAPENEYKSGMIKCGFDISYYLGLSNDDIRKSPKKIDYHEFECMVKTFRSLKAILDKYAIKLLQAFFEKTFIVRNKTNPNPKCLEFAEICSPYFSSKIEFSVMKYYITALLNNFTLKCEFYENNLVLMENFDDEYDVSLFDVNIPYKNILINSYTVFRTLENILKNPYTLEAFKFLLNEMNIESFVINMGSGLIIPDTSFSFRTISIKIFRAITISDFVSSYGSFLLQLDSAIGENIEYITLKRISLSRDTLKILLNKTMIKGLVLHRVNTPESLNFTPIGEFVYDRLEYINFYDVRIQNMWWADFFKRAKFKKIIIKLEESNNAYKNFITEFYKISEIRRDVLYFDLYFHCEKISNEFCQALKCFVNLQTLKLNWNIIDYSSNRNIIETVDNLKNLEFITIIQLSESHLPPSKKSNIKYLHLENIHSTDKYMYRNFFKNNRSLNKIVLVKSRISQYELEEIFALKNLDSLSLTLNYCGYDTCPSKMQNIMSTKIVCLNLSGNGSKFLEDFGILGKLDCLQYLKFSDCGFQTGFLRNINEKCSLRMLSLFYIRGSLDIFDFEGIKKLECLESLNISECELLDCSFHQLFENCKFVKSLRRLYLSHVSLNEQDLQCLKRFINLKELSLNLNEFNLLTVQDYLIAIPLKLYISSFVAKKKDFEIFREYLRSKNINIHIFRHDCFEDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE6</accession>
    <name>A0A4Q9LSE6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1757p0010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001757">
        <property type="protein sequence ID" value="TBU10440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1757p0010"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="404"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="664"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU10440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="718" mass="82584" checksum="2ACD6485EAA7AD82" modified="2019-07-31" version="1">MIVINMQILCGIMSNTPDEKMLEALKSLSSKLSGLQKESALYKIKNLERRIEEKKKGLSEEKDKNIYASCDRKNIEAKINKEKNIVRAFEKLISVDGSLVEDLTAKIQTSEKKIFFLKKHLDKAPDIDEQRQKFSKTTGNVKLKPVSIECDPLYEAKMLDFYIDNELKASANINSNDEIIINLENNIEFEIVLVGKDNVFLGMVFFACERLVIHGKDEDVTFKFEEDAELKVKLSFERETKLIRKNAEIVCVYKDGHALENYYNIAPFYCCVCNNIASLFFESYRCYKCKFTCHKKCANYILFKCPCAKSIETEKHTIRYDIPHILQKQSQLGLNWCNHCGNRISSSESAFKCTKCNQHFHESCSLFVFKSCGMEYDLRIKMADFKPPVSEVQEKDSKIEISDFLLIKVLGRGSFGKVMLAKYKPESSIIALKILKKESIVNANDLVYLELERKILKLVSLPPHPFLMKMEYCFQDSKNIYFGTEFLAGGDLFHLVSKGKFSYQQIKLYACEILLGLEYLHSKNVIYRDMKLDNVLLCEDGHAKIADFGLCKDNIGPMTITHTYCGTPDTIAPEIILEGGYTKDVDWWSYGVVIYEMFETEPPFNGATNGEMCAAILEKEVEFNSDIPSVAKDLILKLLQKDPKKRLGSGENDANEIKSHPFFENVNWEDVYNRTIKPEFIPKSNLTDNFDSYFIEEPILITPTSSIRKYDEYFKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV0</accession>
    <name>A0A4Q9LSV0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1250p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001250">
        <property type="protein sequence ID" value="TBU11357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1250p0010"/>
    <dbReference type="OrthoDB" id="5985090at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="34263" checksum="AC1018BF78B9FBAD" modified="2019-07-31" version="1" fragment="single">IYKFQNLKSLILENCIFLYDNYQSFSDFQQNNSLEHLTINSCIDPLHFFSSIEFYKNLKVLNIENNILYKISKRIVIDVHDLPKLKKISLNSGNFTIIHIKFGEKNTELRELELPACNLPENSFYNISFNMHILNGIRSFSYFKNNLSLYDLYCVSFMNNCNFFDISCCIFHNCRFSDIFTVNKTYKISELYIFGLNLNNHDIFAIRNLKLLTHICISIDLIPSSAIYLFKYKYFERLQSLDLSNNVIQRRIRDYLIEEFGNILEPTININEESDLEEETTVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW2</accession>
    <name>A0A4Q9LSW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1644p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001644">
        <property type="protein sequence ID" value="TBU10620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1644p0030"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="151"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="347" mass="41190" checksum="A2512156E28994B0" modified="2019-07-31" version="1">MSNLKKTSCKKQNILPVYRHLQCHIENHSQVRKECKNTNACFQIVKREPIYFIYSTNNNYLYALIENTYRCTNIDQENKITVQNIPKQDTIQYKKQIKALEFKPKNKLYYSKLSNDEKESLKKYCRYMLREKPKKSCGCIINMIKGFFMGKKRSEVVNKKDINPFIYNVGNYILKEGIKTEGIFRISGRSSLYKSVPYSLKENRGYETSEYTIHDNASIFKAYIRDVLNGLVPEFICKELLETFKGSRNAKSIEEIVIYTIFCLDDMERELLLYLRRMFREIENYKDYNKMTIENLVKIFTPTLFPDFKPFDLTMIDKQIDFIKLLFESDFEEVPIDLLNAAHPNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT65</accession>
    <name>A0A4Q9LT65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1034p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001034">
        <property type="protein sequence ID" value="TBU11798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1034p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020712531" evidence="1">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="47970" checksum="47E55D2AFFC6E881" modified="2019-07-31" version="1">MNFIYFFNESLFLVFGLSFVILTELSNIKDNNTVFCNLNEITETFTKDLRKIHHGIEQCIDILTSYNIFGLKFDISNSEKCFEKILYRIEAKTINKIFFYVVALDSKDKNKNNQFINLFSLSSHLYIRKLAIFVEILTVLKKDQVTHYTHLFGHKNLSTKLNLSNFLLKFYKILAKVLNQLSRVIHPQKNTFLLISPFELNLDSKQALNIYLNRSLVIYMNMDIIYLETKSKSENNIFSLNMENKLKKTFFYEFYNEYTFISRIIKITNKRITSPNFKHNQINYTIKLYRIYDIKSRYITTRPNIFKLETFIKQHTSTDNTKIAIDSKLFISKISLNFENNIIKIRLSNGFYVIVSLEIKVENGIIVFSFLKRHFISSDTIKYGDITDLKEILHYILKKYKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA7</accession>
    <name>A0A4Q9LTA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1028p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001028">
        <property type="protein sequence ID" value="TBU11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1028p0030"/>
    <dbReference type="OrthoDB" id="2198293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="723" mass="86513" checksum="B67983C040BE5B09" modified="2019-07-31" version="1">MKEEFNLFVKKINEKKSKQQPLIKYLNELELLLDKFDDTDRFQFLAILCLEYYNEQDFDKSKIYSKKAVAELLRILKTKVMEKEDILFVVNYLEKCVLVEINIEEYETGIFKKQIFEEKSKNEYFKYFLNYGTEIFNFLILEFKNSKDFDFIFFMTDFLNENNINRLEIFFDLLYLHYNEDKIDFLIQKLGELFDKNKILRDPVLKTSVFHETLLINLVIIDQKNFHLYSEILRNMLIFRKNDLKDLSYILISLFKIEKTCFFKNIIDEFLKFKNLFTTVENNILNSLYTEFTKITNNSINLEILKQEYINSINILYFYFAKKEYEKVVSLYKKLSQFDKKKIPPNIIFKSLVKIKDFKSAEVILQEDINSKFKISEDSFSMEMSCEESDLSSENVFLYYILTNNNIGALNTIQKINDKNLFVKCLKKVYKYNVKQIIIAALEIGIQKFSDDIEILMVYISYIHILEFEIQPEERSEIILKALKDTNLSEYSEKIREWFFTVLYNNVIDLLNTNNPMIFELLERCYEINSKNLGLIEITLYVFKQIKIKDKKEHIKQRIAILYEDFNKIIKLSKDQETDLIHEIFISFYHLILEFSLENQLLDLIPKLYPISKFSLENLKILLHTEISIPHNHTKIKISIINESYKRNILTVELFDKFIITSTFFGPISFYSFLSEVSLFIDIQEFISDFSKNIINTQSLLLKATGHYEIYEKLKNIYLGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG1</accession>
    <name>A0A4Q9LTG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0989p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000989">
        <property type="protein sequence ID" value="TBU11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0989p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="506" mass="57174" checksum="A4324FFEA431EE87" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPSQTCCKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSTCTLAIPEGNRLMALRSIFDSVTADPKEWPRIVFFAVQTRYYIEKFGCTGTLEVLKKLAQSEMGKEVKSEENGERRRIATCPADTCTLTDTTEYINLRDKFLSKIKEISEKEIGKVVVRTRKHPNELVDSKVLDLINRLVGEYAGVHVPESITEAAYIMQAAQICYDEATRKEKPRSAWKENIENLLGMARRQKKLSTSETKSLKKIMQEFNLNLGRVTDLSEALVKKNESLNVYEKKITMHEKNRMFELFRGRFYRGLSEGVESEYVVSRDEIESFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDVICLEGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQVEVERRGLLAENQLGAVRGVQGAKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW2</accession>
    <name>A0A4Q9LTW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0965p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000965">
        <property type="protein sequence ID" value="TBU11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0965p0040"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21036" checksum="D68E0AB1B77F9120" modified="2019-07-31" version="1">MNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTLDMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINNKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY4</accession>
    <name>A0A4Q9LTY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1405p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001405">
        <property type="protein sequence ID" value="TBU11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1405p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20649" checksum="3B5A01E95B6280CF" modified="2019-07-31" version="1" fragment="single">IYVAFFSNTDEIIEKICQTSALKNIKILNIIYSKFTTKDEIIFLKKYNIEKINYIILPNAPKTYFHNSAIYSPVHDLYLTSIYEISENNKKVFAYKNRKLNKNIRKNLILVCHHNESMIEKVENSNSLSSMFLCVKLYNENFWFGFFALNLKEIKNIDVRFADTYIKDFEINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU61</accession>
    <name>A0A4Q9LU61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0862p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000862">
        <property type="protein sequence ID" value="TBU12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0862p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="532" mass="63429" checksum="F3601315EE043D82" modified="2019-07-31" version="1">MFFEQYKLMFFWSLMKLAIHNESKEILAEMEKAKNDEARHKIVTIFSNNSGINPLMCTITINESTTKEMNKEDKNISNNSKNYSFTISNCVLVSQNITIPHNSSIPIFIDYHIDSSNNIQGFDQSSDHTLAGRNIVPSIQAQNDETSFHPVKNKNNVPKHNNYKYDIEFVRFFFTNKKNIQNPTVIFEQIERIFVHNTNNTLIIKNFYKKNKYIFKDLYDIEMKMQKNLQNSNIMDEVLRIFLEKMSSIKIPQTNCPILSLFPGLILLNNFVFDKITTVATNETSIFCIFYGSKIIEKILQNHTSYFIENSNNLYGKNVRRPDFKLNTHFYMIIENDFRKILEIVGLIRNLLGFPNESKKIIYLVRDIYFYLVNDFIGNHFANDIILRCVLDLVFLFDSETIEYLKLYFYEKADTENRTRANFKSFFYDYLNFKNSISIKFIDYYLNLFQNETFKNLIIIPKDEYNYFIDYLIEMKEYMKKSHENSSIRRIIFKVLKNSQIFLRYNINIRLNSLVFTDIYKQKMENCYHFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU82</accession>
    <name>A0A4Q9LU82_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0995p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000995">
        <property type="protein sequence ID" value="TBU11887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU82"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0995p0020"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="23404" checksum="28C527679A241803" modified="2019-07-31" version="1">MNTFLIYSLLIFTTTQAMIVFDLNGVLMKRLNKAKSKEIKEIETNNVMRDITLNSSVVFLRPNFKELILFLRKHKARYIGWTTAISSTVEELKLHLKGWGFEFEDILSQEYCDVGGVRPPDIKSEKWIKNLNIVAEKYKCSLKDCVLVDDSRNKSVEGQNFINVSEYNPLSNKKDQYLKKLCVALHDYVQCNDDDCEYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF2</accession>
    <name>A0A4Q9LUF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0284p0080</name>
        <name evidence="1" type="ORF">CWI38_1231p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001231">
        <property type="protein sequence ID" value="TBU11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1231p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9301" checksum="AC6410E86A7A2BE0" modified="2019-07-31" version="1">MVNAYNMRRDNNVQRACLMFKCVPNGICKRHLPNDEEISNSKSVKKEVESIKDNSGMESLYDLCSELIECKNVSLMPNPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ6</accession>
    <name>A0A4Q9LUZ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0735p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000735">
        <property type="protein sequence ID" value="TBU12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0735p0010"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7701" checksum="D5759D3551667D29" modified="2019-07-31" version="1">MAYHIQKLRCASCAYPEAKIRNPCSEKCKRKRGYGTGRLRYVKRIGKRFVHPELKALWDKRGITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC3</accession>
    <name>A0A4Q9LVC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1059p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001059">
        <property type="protein sequence ID" value="TBU11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1059p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15584" checksum="8418DD04DF5A19B4" modified="2019-07-31" version="1" fragment="single">MTWDGIVTKYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC8</accession>
    <name>A0A4Q9LVC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0685p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000685">
        <property type="protein sequence ID" value="TBU12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0685p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="8639" checksum="C4D097713BFAD7D2" modified="2019-07-31" version="1" fragment="single">MYSISDLFDIFDSGLCSGVVVGVGVGGVVGVGVGVVSRDTPIVCLCVGPCVVGVVSGGVVGPCVVPRDTPIVGPPVVPRDTPIVCLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH8</accession>
    <name>A0A4Q9LVH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0665p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000665">
        <property type="protein sequence ID" value="TBU12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0665p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15525" checksum="D0020E20C59BB99F" modified="2019-07-31" version="1">MTWDGIVTKYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKIVKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW12</accession>
    <name>A0A4Q9LW12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0584p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000584">
        <property type="protein sequence ID" value="TBU12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0584p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="15372" checksum="88D3257C14226EBB" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW55</accession>
    <name>A0A4Q9LW55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1012p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001012">
        <property type="protein sequence ID" value="TBU11850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1012p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="11312" checksum="FBA9333FCA6F6657" modified="2019-07-31" version="1">MTQRNLESMAYYSELGLVNKYSVEIIPYVISRNSIVTKYRLDSVDNIQEDSQNNLFGLGRCFRGKRNTDDLIREMHNHPTSSLKQLKDEKDSVKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF0</accession>
    <name>A0A4Q9LWF0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0873p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000873">
        <property type="protein sequence ID" value="TBU12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0873p0020"/>
    <dbReference type="OrthoDB" id="5966140at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31419" checksum="EAC30C2508BBE908" modified="2019-07-31" version="1">MFLVAKSVEDAQLAKLYNEIEKRKLHSKLYNARGNELVSVNDSYRWLKKGNIRLHDETVFCYIQDRNVFWGADGLCQRCNKSGKAVDHIATRCEKMLGHDYNRRHTEVARCLHILLLNRYKFKSLKRIGSHSVQEILDNEYAEIRVDTRIKTAIKIRNNRPDIFILDKKKNKITLIEFLFYKFSADIIPYVMTWDGIAYIQSIVLKKTVETISIDRRRGLEELGKASMGVIMRSEMHEESTPPLKEEKREEDDAKNLKTENITLLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG6</accession>
    <name>A0A4Q9LWG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0534p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000534">
        <property type="protein sequence ID" value="TBU13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0534p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="701" mass="81844" checksum="373912A711292256" modified="2019-07-31" version="1">MIGLHKNDSGLINKNLPVARFLIKKIMSNEVLEDKRISNIQNISTDTLNGEARDEKSVLSVSEITKKYICPKASVEKIKYFKDKEIEKIPGDSEYHMAAKTTNTFSIVPYKVNKPEEIVGLKENVKPENKKSVDSGSIPLNRNENLQKEEEFVHRNVSGELEKGRENNNYTIQKFFIKEAKKINIKKEYNNWDKNHSDKQEMESDFKIRSNEAKIVPIEDEGIEGSQTEKIIQQNKERMGNLGCKIINELEETKKVLSIVHLNLDQNKESNECKKAFENFESENKNSNEESFIDKILMINSSNIIALSKETDSKQCSDNNFDGDYSKKECLINVINEKTKLVDVQAELKEEYCIGTEKDTNKETEYEFDGSECKMNKNSCLEVENFHQPNNREIIPVDSFVKCEYTGNEKSESKNMIRRSEKQEILYKRVLKQIVSRENVYIPPYNKKRMLKKNSLTFKKSDVMSVDTSLLDREDRIKIEEHYRKLLDRKIEQNESGVKKWFKSLFGCYRIKRNRIVNSIDNFIFKLIDFLIMSNISCTYGFIKEINNADVKEKIKKIEKQEYYKIEETNVLTNLGVVLFYIRETMNGIIPHHYRKILLNKKLKNDKKKLDSILDLMKFAIGHERIKMIEKIKNLIMNMKCNSEDPKLVGHLINIFSKAIFPLKENANLKNDIHVLNVINFIFQSDLRSISLCTYYEATKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH4</accession>
    <name>A0A4Q9LWH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0532p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000532">
        <property type="protein sequence ID" value="TBU13099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0532p0050"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="766" mass="89279" checksum="A51240E7FEBA540F" modified="2019-07-31" version="1">MKIIVVVHHLPLCVSINKNRTEAMKQHISRPLIESKQFYRGRNLTSVLKASHDISIENENELHFFYKPMHSTFLRDMHGDVVFLGIPGLFNQEIYNFLTEKEKKEIHEKFMKHKYHPILLDFSEFEGRYNDYSEMKVRNVCFCTFWNDVFLRFDEEPAFRDLKKLNQIYLEKLMKIYEDGDIVWIMDHEFWLLPRMIRDLKKEAYIGLSQMVPFPSSELFRCLPNPKIFLDSLLSASYIEFQNKSYLDKFIFTNSNIMGISGKSFIGPDKKVTACISRNDSRVFLGVGKIGIDIPKINTVLKAPECQEIAKSYSEKYKGYKILVSISTLNNSYTNTNFLMALEAYLHKYDKNIALIHIEIPEGNTDLEIKSETHLLKQFLMVNYPLVRIETVISEDDFKYYALLSIADLGIVLSERSAISRPCLDFIASQEKNMAPLIVSEFSHFNDDLNLIRVNPKNAVDIADKMNYALNLDPETKIEIHSTLINEIETHNIHYWMEHFIYNSAKHKHISFKKSIDYSEIVENYKKADKRLFLLDYDGTIQDICPLPEQAFPSEEIKNLLKKLRSDTRNEIYIITGRDYRNANDWFSSLNIGLYAEHGMYLKNGKEWVSDPVDLTWKNQARKIINFFVERTPGSQLEEKNTSMVFHYRNSSQLIKKKQSIACKNILEKLLAYKKNLEVTEGKDIIEIRVNGLNKGKIARKIIANQKYDFILAAGDDTTDQEMLEIGLSTKKFYSVSVNKGDSCAKFHIENPGLFRKLLLQLTEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU4</accession>
    <name>A0A4Q9LWU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0622p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000622">
        <property type="protein sequence ID" value="TBU12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0622p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="49361" checksum="A756E9E5736160C4" modified="2019-07-31" version="1">MLKHVKIRTRETKSEEDGKSDIENNRVGLKDETNVFYEKPTYVEFEKIDEELDDHNLVKRCNSNDLSQVEIEKGKSPLCANLIQYVGGEQSLILDENAQETPSTISVTDEVEKSNYQKQNNMIYGTGPQKIEMLRTNSTDRSEYHKSNSIYETMLFSKPGLIRQVRKRSFTNRNSFGYQTQSLDRCSSFLHVLGTKSRIEEPLGKELSEVQKARTYERSALLVESLTGINLENQTNGNHIDTENGVIGLLNTEKTSTIRNATGNHLDTENGVIGLLNTEKTSTIRNATGNHLDTEKGVIGILNTEKTSTIRNATGNNLDPEKGVIGLLNSEKRKNLKFLSFFKNLKLFLTTFMAVISTLSLIVFYFYLGLNIILGTPFPKHLYILNLSALCLILFTLILLFSSRNTKNSRIIIYNIILIIFTILSFLISAIKQNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV6</accession>
    <name>A0A4Q9LWV6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0878p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000878">
        <property type="protein sequence ID" value="TBU12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0878p0040"/>
    <dbReference type="OrthoDB" id="74246at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13396" checksum="EB12985560FE7957" modified="2019-07-31" version="1">MDRLKFCLSKVNLANNGDLIFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEEKPERNCKSKPFITKIMFMAAVARPRYDAHRKLFFDGKIGIWLFVYQEPAQKNSKNRAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX69</accession>
    <name>A0A4Q9LX69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit 8 of transcription factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0798p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000798">
        <property type="protein sequence ID" value="TBU12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0798p0010"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19935" checksum="352F3E90FC2296E2" modified="2019-07-31" version="1">MEKILEKCILEELKRAGYQKLNAKALYMFTQTTIAQIKTNCNILSSLTLHSMRSRSTLLDVMNLIKLTKIDYSNVYNRPTVKYEVEEEPKPIQFKSSISCSAEKFIHIYDFMPDFPPVHTFKKSFLKENRSEDKSEKVKQRIEQSLKTESSLLKIIACSKGLPKRINFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX83</accession>
    <name>A0A4Q9LX83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0568p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000568">
        <property type="protein sequence ID" value="TBU12976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0568p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="54" mass="6299" checksum="DB46B8A9EA962865" modified="2019-07-31" version="1">MIEEPTNNINKESDLEEETEVVKEFLNYNNIEDLAYGCEIISHQVYTLVDFSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX97</accession>
    <name>A0A4Q9LX97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0739p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000739">
        <property type="protein sequence ID" value="TBU12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0739p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="84" mass="9701" checksum="A7B7C26E982FCADA" modified="2019-07-31" version="1" fragment="single">MILINLKNSLFYTPFSDEINSVSFFTTNATHRQNYETTDNIKNKEIVLKHLNALNINLLNIHFPVKIPMVLQQQNISDVEDGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC4</accession>
    <name>A0A4Q9LXC4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0568p0040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000568">
        <property type="protein sequence ID" value="TBU12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0568p0040"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="486" mass="56277" checksum="D53F80B92B1056A5" modified="2019-07-31" version="1">MEYKEPLKITKRLKDKSDRATTDKVLDPKTMAIITKLLSRNAISDLQGSISTGKEANIYVALVSPGLKSKFINSSDETNHGITDDSSKNIKNFKKNSEGKPFHRVDQNHLISLNQENLNKSDKTDELRNEYVVNTNSSINEAISVSKPTKEKIFAAIKIYKTSIMPFKDREKYIQGEQRYKTSTSTNPRKMVKLWAEKEVRNLKRIRKSGILCPKPLYLKRNILIMTLIGEGSDAASKLKDISVSHDEFQSIYLQCLEIIKNLYRKAKLIHADLSEYNLLYYQKKVYTIDVGQSVDIYHENGISFLIMDIKNINAFFSKKGCEVKEINDFFEEVTGFILPECLSDIEINHKCFVPTCLNDVFNTEDCKNFTSQSFDTKIANIKSQEKNLEFSTENTQAESITMEKDKINKIKTTYLDINIDSENITIEEECKNETKLSRKEKWMLIKQKRKQVKEEKRIRRIEKTKKTSKKCKPKHKNNKIKILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM5</accession>
    <name>A0A4Q9LXM5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0401p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000401">
        <property type="protein sequence ID" value="TBU13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0401p0010"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020826381" description="Trehalase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="669" mass="79100" checksum="C109C8C51CF938CF" modified="2019-07-31" version="1">MRFYCFNSLFLFFNRHILAAKEEMEVSQMQNVVDKSENPMLSRVHEKLLSDKSSKPEDNESFLYQATEDISGSLERKKDFEYGICLSKSDSIDEMEKYTHLELFIALNVLEVEDIKTLSDLVYKFDTKKNFLHFKENLKIVSKAISSFKTLKEYVLYILSLYMPYKEQIETFYRKNFYLPENNLENVNLNFNRSLDRFENLKNKDLKRVASHLLERWKFLCKKHVRPFDVAGREKTYSTLVLLPNNFVVPGGRFLEFYYWDSYWILRGLITSRLMVQAFEVVKNFIWLINYFGFVPNGTRKYYNRSQPPFFVLMLLELHKTGDEIARKLIFEEGIPAAIKEMQFWRENRKVEIKRNGHVFTLNRYCVDTDYARPESFMKDISDFEKMQSNDKKVENKFYTDIKSAAESGWDFSTRWFSNNASLQSICTSDIIPVDLNTLLFASEKNLDFLIKEHNFLNQSGIDFGDLSKKREEAINSVLWNPFEKSWNDYNFKKNTFTQDVFYFSNLFPLFFDIKPVDGNVYNILSKYCKILFYYKGIPASGYFKENTSGEKVYSGQQWDFPNIWAPHQQLMVEFLCKINEKSLALKIARDFYQHVKSLCGEEGIFYEKYSCLGDKAGGGEYENQFGFGWTNGVLLEFIEKFGDDLTLKEIDYDTICKIVESKKEKPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY62</accession>
    <name>A0A4Q9LY62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0340p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000340">
        <property type="protein sequence ID" value="TBU13791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0340p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020808407" evidence="1">
        <location>
            <begin position="25"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="459" mass="55267" checksum="FA8265804DB42253" modified="2019-07-31" version="1">MRNILFSLWVFIITVLCARNPVKSNKCSVETLFSIINKEIFKQYAEKTTQYDEISSNEFLLLESYKYMNTEATDEIFKFLLAKKSKMFQITVTYMYNDENDFGYVYHASILVYNNIFITIRLLGKYYRVLNKSIFLKSYLHYLNSDIKKYYLQKHISMLIFYYLNIFKTIFSKLQSKKDYFHLVPIFSDIVFFKDVDKDFLFPLLLKQKYKSGYDYYLLVNDVRINDKYDENKKSKCILEYAFTNTTFESIKNLSFRRVEIVTKSRKKYPHQNITNKFVATEIIICNQSRYLNIYDIFLSGFRDDIEFEESELKENEFEEKKLKEKKSEENKLDLINCFGYKSANIDIFTFIIINKLENMKKNKQSKKDKKNSKTDKNIQDIAYLNIVNREFDIEYDIKIYYKLYDNEVVDILCDQSITGFSSDMSLKEKISFIIRFVKDCEKYRFCLIDRKNKKSIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB6</accession>
    <name>A0A4Q9LYB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0345p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000345">
        <property type="protein sequence ID" value="TBU13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0345p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="95932" checksum="D638F08038E9A71F" modified="2019-07-31" version="1">MGRKKVDSENIKNEKVKAVNISEIGLKRIKTCFCNLITISERLSPQPIILNKTNLPSSNPLQATLLCLVETIPSVFLPANTIKNLNTSGIPEGNRVIVLDSIRDSVQKRFERMHRNGWSEILRYYNEKFARTVDIDVEIRQEENKQRSRIARCLAEPCSLTDNTFYMNPRKKFLCKIKELSEKGIGDLESIKNKTTKLLLSKDLLEKARKQEKLSTSETKSLRKIMREFNLDLSKINDLSEALVKKNEALNVYEKKITMYESRRKFRKENRMFELFRTTFPSLEEFIDIINWLPNLNVAVFNSIDNFYFEKLTTLHRYLYDIVKVISDWYYCGLIYLIPKGTPKTGANYKPITCMSNLYKLTTKSVARIVQIEMERRELISGIVSVTIVVLLCMDPLSRKLNEKYTKVTIKIDAEFPATNHLSFIDDLKLLSKEQQTLEEMTEEVLNFMNNVELEINKERSGTNDPCCKDTATLLEGIGVYKYLEIIEDSREIPKAIEKLCRTRLIARNLFQAINQHAISFLNYYIGLDDAVRVVLVKNKIHLRLGYKERLLYLPRKKLGRGKHSFEFKSEHMLLKLLDFLEKHKDTSTRRAAILKVENNNKTYLSLIKNFLKIKYGLEEVVAKKKLEEAQLANKYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVKLRDEAVFCYIQNRNVFRGAEGMCQHCNQSRKTVDHLATRFQEILDNEYAQIRVDTRIKTFGITTQGSLQKVETEKLRKYDLLANELGLILITYVTRLQLPMNVEAYIKSIVLKNTVETIFLIDEEDFSLDQMPKRAYLSVILGAVMHKQPTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF3</accession>
    <name>A0A4Q9LYF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0629p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000629">
        <property type="protein sequence ID" value="TBU12790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0629p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1514" mass="171075" checksum="E29FFC5A3257D1D9" modified="2019-07-31" version="1" fragment="single">MLTPITSISHTNKTLIYTKNNTLYFHNYHISISLPYTIHNIIIHHNKYIVTYSSNKYTVFYIKNRKENKNGKEDKDSKYNRYRICNKYNICNKYNNFSKDNNLSKDNKYNICNKYNNFSKSNRDNICSKDNRYRICNKDNSFNRDNSFNKDNNIGNDNRANNITSNRANNTNNNPNTTNTTPYPNPTLTLNTRINTNFLRKKYKKKHIIFTSKIEKIKENKYFNIYMLLTDKLPTYITDIKIYDTKGKVYNIKDTNNTDDKVYISNTNNTDDKVYINKVYISNTSNNNTDISNSYNTDDNTTDISNKIYKDNNRVFILLQNNIIYRQMCYISSTTCNKNSVIYKYVNNTLYSRNSISSVSSVSTNNTTNNTTNNTTKDNNTLYTSDTLECTTGVIYKVFNTLYMLYGTFKGILYINNKPYKLHRGVIYDLKVKVYNKGIYTNPTLTLNKCINSFTINNPTIDIPNPTLTLNKCINSFTIDNPTIDIPNPTLTLNKCINSSTIDNPTIDIPNPTLTLNKCINSFTINNPTIDIPNPTLTLNKCINSSTIDNPTIDIPNPTLTLNECINNLTIDKSINNIQNTYIYILSCSEDRSILLTIIKGNNILLKYRYYNLKCRIYKCGFITFKRVFSINENGSLYIYKCILGGVSNREVVGGVNNKDILEGVNNNNDTNNNNSNNTNNNNNNNTNNKDNTNTNTNNNNNNTNNNNNTNANNNFNTDHSLIPFICINIPYSLITNTYIYNNTFYMCSSSGLISYINNIYSVIDEGSNYKGVIDKECDNTPLTTDITDITSLNNIPSNNTPLPRHSNNNTTLNNISINNTPLPTPITNNTPTTYPFITSVILNRYYYKNYTYIITPFTLYIVYKGYLLYKINKKITSFNKGILGTRDGYIITPLHITGCDSMLDNIYDSILNTNNSMLDNTYNPLLNTSTNNPLLNTSTNIHDNNPINYLTFKVCKDALTGILLYNKGIYITSRDGYLYYINNKEIYRYSNIGSMGGVSNSRDILEGVNKIDSIEGVNDIRSIECVSNSGDILEGVNDIGSIEGVNDIGSKQQGVNHKLMLEGVSNIGSKQQGVSISTSKQQGVNHKHMLEGVSNIGSKQQGVSISSIKQQGVNHKHMLEVVSNIGSKQQGVSISTSKQQGVNHKHMLEGVSNNSSKQQGVSISSIKQQGVNHKHMLEGVSNNSSKQQGVSNSSIKQQGVNHKHMLEVVSNNNSKQQGVSNSSIKQQGVNHKHMLEGVSNNSSKQQGVSNSSIKQQGVNHKTNYNTTYKNLKSTLNNTPQHTLINTPYNNINTLPFIYMYVNNTPLEGIYINNNKIYVYGFNRCYFYITDLTREYYIYIGYNPKTYKVINNTLYYIKGNNNTLLSIKYGVNNNIYTLVEIDSNYKDKDILEGVSNSRDILVGVSNSTDILKGVSNSTDILKGANSSSKQRGVNNSSSKQQGVSNITNTLHPLNTSTNTLHPLNMSTNTLHPLNMSTNTLHPLNMSTNTLHPLNMSTNTLHPLNMSTNTLHPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL4</accession>
    <name>A0A4Q9LYL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0603p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000603">
        <property type="protein sequence ID" value="TBU12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0603p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9395" checksum="056A4C0BEDCE9B3B" modified="2019-07-31" version="1">MKKTEFKKDKIDILESKHKEIIERLNRERIEYDIVSNTRRDHPSVFKTLKKQRLSRSGTSGMFVFGDSNVLEDLELIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU7</accession>
    <name>A0A4Q9LYU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0423p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000423">
        <property type="protein sequence ID" value="TBU13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LYU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0423p0030"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="1425"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="1555"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="1636"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1861" mass="217158" checksum="D72AF57168D9BE99" modified="2019-07-31" version="1">MLQFLLVFGASQARFYVREMIGVKKKLYFISDKEKNDATIKKYFLTPLLWPPINAINEFLKNFDTTHLWCSSRDRSIKIIRNLVLYPNICYKTEIQKKIFYSLESCNECLKNYYSIRNEIVTQKEEMILLNGEEKRIEANITIKNNFFIVSEIYRYNWKMLKNKKILAWFQGAIANFFIRGSKEFKTLKFPFILIFLSENKILLDCAINNLLSVYLESSCYLCTDLEQWNYLLEFRNSSYILVDNETPLKSINEKSWLMALFVYVGIEGTFINEDIVKPLISIYKETDAKEIRILIFKIVYICIRRNPSWLPHFVFILSTIDCYKYFLTKVNITLIYDHYIFWASINFFINSYDLYCKIYLENKYFEFLAELTNDLNKREVFKVILGNFKFTQNYLKFLTNFPFYEELIMILLRSKDPRFESLLNIEPKFIDFMVTKTFFYIFKLPKINLEMQENLSVILQKWKNIFIFSEKILLELHEEKTLEECDKPAVENESKVSFTTAYKYLEFSKLNGFYNIFFFDIESYMRKNNFPVSLIETYCKLRDLFKLIFIKMQKGDIKTMTNEQIVYHSVFKCNTLTSKQKNKFKIKISEITPMLLSDILEKIFIFNQRYNEFPIYTLQILSFVRQCSYFNVDILKKIFAMIKTGFSYWQILYLLEYITVQMRFKPEDDLAYLCNFEWLECLTKAKFKKYNIRVFVILENILSVLSNLNISVYNVNLSKICKCYVFFKLIPNSSVIKYVEKISKNLNCDNPLINLKEFELQDCQKDDEMNSPKRVDISGSECEIIVEKKKPIKVKKNFDKIFEEPSEDGISIIEKNESIEEKLDTDKISKEPSENGILIPESKETLKEKENNDKISKEPSDEDRSTFETEMEIPRSEMKISNLPLFSESSFAEKNSNNEEKIDDENKKSEKKMINQENESFKNFKSLVSDENQNYCIKNNKEVGDDNKILEVNSAQIFFNMKKEAIGNRSKTNVFFTSFGTQNIAHEANETIILDSKELINGIKKPVELMNEDITDNIIEPDTSADAVCTEIQELPELELPHSPKRLKSKIDYNFETTESLNTDVNQDISKTSLPIISIEFENQPLNNDIDIKEQILEVRSTDSIENENIQGNNILEQKPEEKNDLLEIEEINDLTELSSISDEFRIVKIKQNGITKEVFQNVNPSKNLQNFTEEKKVTHRTTIVTPESSAFSLYEKSMKTSNLIQVNTGVSNSINKDGYTFDVSFFIKRVLSFESITSGSLYKNFYIPATFNSYKEYFNIFKPFIFEEAKALIEKGIEESSTEKKIFILEELAHINENADLFLISEINPNFQEFDFVSIEPEKNHLNEIPISYFYGVVLSIKPVKSSFYVQVRIFGLNTKFLKKKISLTLKYICGLSTVFREYNSLFYFKNSSLSDFILAPNLIPLRNLKVKYTAAEVARNFELNYSQAQSLLACFNSTSPFTLIQGPPGTGKTKTIVAIVAAFLNSDFYIKKFTKPRILVCAPSNVAVDELTRRIHKEVPRLSKKNDILILRSGVMVQQAEDMIPFTLDFLIEKADINFSNSTDISVNFMDKKKKRNYILQNCDIICTTLSSSCSDLMVSNSLDFDVVIIDEACQAVETSTLIPFKYSPDKVVLVGDYKQLPPTIISNLLPFEKTLFDRLSKYLPVNLLRMQYRMNPLISKFANSYFYDNNIKNHPSVISRKDLYSKFCKPINFINSFGTEIFDKAFSFLNENEAESVVRLISKFLFVFSGENLNGRIGVITFYKSQSKLIKKKLLKLGKPEILKIVEVNTVDAFQGQEKDVIIVSCVRTRGLGFISDQRRINVALTRAKHALFIFGESKCLEKSPCWKAVVSFYKKSSRFYINSKSFFKTGIICKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY6</accession>
    <name>A0A4Q9LYY6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trm112p-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0560p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000560">
        <property type="protein sequence ID" value="TBU13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0560p0010"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14726" checksum="011EAAE765237692" modified="2019-07-31" version="1">MKPFLISILKCNQCDSEDFLNVFIEKAEEIEIEDLDFIKEHINKFYIEKGKLLKNIIKKLEVTSLNENDCDLLINGDNSKLKEFAKVLLGYEIFEGYLECSNCQVKFMITDRIPDFVDFVSSNKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ11</accession>
    <name>A0A4Q9LZ11_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0550p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000550">
        <property type="protein sequence ID" value="TBU13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0550p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8551" checksum="1BB2BA558BAD6F91" modified="2019-07-31" version="1" fragment="single">RASLSVIIGAEMHKEPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ68</accession>
    <name>A0A4Q9LZ68_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0386p0020</name>
        <name evidence="2" type="ORF">CWI38_1105p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001105">
        <property type="protein sequence ID" value="TBU11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000386">
        <property type="protein sequence ID" value="TBU13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0386p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1105p0010"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="34547" checksum="839C6721631C8C8C" modified="2019-07-31" version="1">MDNDYYNKKIKLRDSKEYHLEEEYEDDKCETKSYNERNKNCLIKKMIQNENYGAKDNNLHYFKRSMQQNDLNYQDFEAKRGVINGKIDEFSLKAQSLKAINYFNEKTKTFRSSICKKYGFDAISSYEREYWKRPNYHDNIYGQKNIYLKNKDSHIKYLEQQCVFNFNEISKESLLGLLNRLMKIDSFFKNKSNFLPNFDFLLQQYDIFFQRKKKTKGGILGINEKRRNHVNSEHRRKDAISIGINALGDILPNQDFFEDDADIVFEAVFYILKLRYKNILLRNNIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB5</accession>
    <name>A0A4Q9LZB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0344p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000344">
        <property type="protein sequence ID" value="TBU13756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0344p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="39191" checksum="568EA9E6877A74E4" modified="2019-07-31" version="1">MAQSFVIIPIFKKNNNFLTEAKQFHLIEEVIFIKNKNRDPKAIGDCKSEAYPRTFEEHYLPNHIRMTEMFSSIAMICMGFRDGFNPRIVAEADKTEIVNNENDGNSDGKFLLQTDFFDKTCCPSNELLYIIKTKSDTDVHYNKKEALIQTKIPKRCNMELSSEDVVWISLSEILNNTYAEIRVETRIKTYVKIWWNRPDIFILDMRKNKMTVIEVVITYQDSLQTVESKKIRKYDLLANELCLIYKFGAEIIHYVMTWDDISRPNAEERVSVTVILRAEMHKQPSLSLKQVYNQEDGVKTENTKNILSLILDGITSAEVPKINANEHSELEEEIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC9</accession>
    <name>A0A4Q9LZC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0339p0020</name>
        <name evidence="2" type="ORF">CWI38_0470p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000470">
        <property type="protein sequence ID" value="TBU13316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000339">
        <property type="protein sequence ID" value="TBU13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0339p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0470p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445420" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="38441" checksum="C98926FC5900EC47" modified="2019-07-31" version="1">MILFTVFFWNYILLSNETVNSNFEDKITPIDLNSPLLVNSYFINMISYNITWFIMSGGGYTDNDLILETILNNVINRYPPHVEKYFVELMNLEWDGSLGLYKFKPVLPNKCYWNIVDKLVYRLKNTVLEIIIKNRDFDLFFNEKIGKSTFARFCSKIDKVKEYLKYTKNQTKRYITNVTNKKICYDGFLKYKNNLEYLFEKDFLTRNSTINCKILKLMYFFEKSEISDIRALNIIFRNFGIGFDFKEILTDIFQQIGILFYIFEFDLSKEVKDREIKSLFWDYEASKMYAHQEYLMEYVTNGLKPHIKKYMDAVIQKMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ3</accession>
    <name>A0A4Q9LZZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0184p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7190" checksum="E42F97DAAE106108" modified="2019-07-31" version="1">MPRRAGKELEICVIKTVGIHGELTLELKQAGNEEDSELTININEDSDLRRKDGGKKGRRKCIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D0</accession>
    <name>A0A4Q9M0D0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0237p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000237">
        <property type="protein sequence ID" value="TBU18516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0237p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="20289" checksum="D1A2634A02E53AA0" modified="2019-07-31" version="1">MIYIIFCAKVTTIEEDDDSECTQNLCYDGGSEELWQYEYIKGAMYNDDINPKNECSNTYNHSYGSYENKSFESIPSASGFQHQLIAGKRKASGKEIYAQAIEVSKKKTITEQISLINPIGDAVLEDATIDLSTRSSENFAGENPMLHYPGHWNNVINTIDSYIYKSKHNIILLCAETTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D8</accession>
    <name>A0A4Q9M0D8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helitron-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0403p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000403">
        <property type="protein sequence ID" value="TBU13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0D8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0403p0020"/>
    <dbReference type="OrthoDB" id="2287175at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12504" checksum="A8A579152D3EFE58" modified="2019-07-31" version="1">MKQKYQDAMAIVRKYGKPDLFITMTCNPNYAEISENLDANEKRENRPDLVDRVFREKHKALMADIIKNKIFGKVKAYCYVIEFQNRGLPHAHILITLEAILSHAMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R1</accession>
    <name>A0A4Q9M0R1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0366p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000366">
        <property type="protein sequence ID" value="TBU13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0366p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="319" mass="37284" checksum="725649B961E837D2" modified="2019-07-31" version="1">MKHLQNLTITRLNKIEKLPTKTKTNRENLKNELKELFGKNIQKNMNSYEESGRSKNNEGIEETWERLKNIILIEAWFDEEYKIALHAKPGTKYIVTETNAPEKIYLYKKDISRVFECIFNIRGLPDQHIIHKNTLPSFSYSDSSVCRPDNIMEDLNTADIPEKNRLILLHLILDSVTAAKRNAEGRRIATCLTEPCLLTDNKLYKHQRDVVCTIPKLSEKKKENRLHIPSKKLRRGFYSVMFKSEHILLQLVDSTILKVENENNNHFAETKTYLKITYDKKSVRPLYKTVFCYTQDIHLFCGNEGVRPTATLRTKQLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S3</accession>
    <name>A0A4Q9M0S3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0232p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000232">
        <property type="protein sequence ID" value="TBU18731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0S3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0232p0020"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU18731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="27720" checksum="CC04ADE1B176B416" modified="2019-07-31" version="1">MKTVQRVIVAFEYILITTTVCYIFLSLYDTLKAKGYITKAILLYFLLVSSYYYLSILVKKDVHILPNTEIKGLCRKCNKLRCTRTFHCDTCNLCFYKRDHHCPWLAKCISSSNYREYYFFILFTVIYLSLKVLCGCLYVNQIVFLNNYLLTILSFFFIWTNFLLFIDKTSIEYYKSRKRLNVSRYFWQEIDFCVCFDRLYEVLFDREIMNVLIMFFPFLQKRTSIIEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T1</accession>
    <name>A0A4Q9M0T1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0104p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000104">
        <property type="protein sequence ID" value="TBU20250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0104p0010"/>
    <dbReference type="OrthoDB" id="10652634at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="31452" checksum="E4D6DD861466EF99" modified="2019-07-31" version="1">MDKSFLCSKKYPKENKSLIKNLCISCKQDSNIVIKDTEYCNQCFTSVQLKKYRKNLDTIEKDHKVLFCLSQSLISYVMLFFIFKCFRLKDKIFILVSTDCDKKILDLIEKFQLNIIKDNFIINSNYEEYRTNMINFASDNNFDILLLDENIHMLVTFVLTGFCTNQIQNLNERIQNTETYKNLYILKPFSNFIDKEILYCYFLFKEIVSFKIYNFKFEPLFLKCYDFVYHLSLRNYSTPFNVINTLKKAFLEIKEEELNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U8</accession>
    <name>A0A4Q9M0U8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0099p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0U8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0050"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="449" mass="53859" checksum="8F4DBCAA3855C2BC" modified="2019-07-31" version="1">MLKNVENYFKVKPLSYKKITIAYSNHVYAIELPDKRKFIYKESPIENIEDKTLNLNHFTDKKLNKEDIIEGNNLTNNNNLNQKIKICEDFWLKYKQNEINDISLNKCNHKSNFKSINIPNVDTLVSLYLDFPKILFYDENYRIEEYVEHDEVEWCEIENIARAAVSYHRQNISFLEDYDSVLSNISGIDFKNTKFGFSISSEEKIIRTIFNKIKNIKFSEIMKQECAVELNTSKNLYFMDKDNDYDSDETICKICYPLFHHKTSIVHNDIHLKNMMKIGEDIRLIDYEYTSTGCFLMDIGNIFCEKMFDYTVDCIPKMERGYSENDKKIFIFDYLKIMFNQDFKKNNENSFFIKKGESIFENLNFKDCIYFENDIHINNFVSKVLKFIDKIQAYSHLFWYLWSRKLILQNKFPCEDFDYKIYSEYRLLFLFKKGMVSRDEIILLSDELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M127</accession>
    <name>A0A4Q9M127_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0086p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M127"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M127"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="908" mass="106676" checksum="780E9DA6F41AD415" modified="2019-07-31" version="1">MKIKKLKNILLNLLIGYGTLVFSSDHDFFYTWKQDNGTLSVVDLRENDLNRNPNSFLRPIYEQNHQFNPGPSTSSDKFLNDYFSQHYQAKPVQSCGNGLFHSHEKNPPDYLNLDQELSDDIFETNTRLEPDHNSGNFRSLNQNTSCRNTPLIMTTARDNSFLLQQRHSSVRQNNQEIYDCEDEDDNIKLACSDFVLDKANDTNDQNDPNYLNALNNPNDLNNLNDLHDLHDLHDLYDLHDLYDLHDLYDSHDLNHLNDLHDLYDLYDLNDLHELNDLHELNDLKDLKKSNNPNNLNNQNDMNDFNNPNDLNNLNELTDPNNLKNLNDLDSLNVMNNPNETNNLNAMNDLNDATDLINTTHSNTPNTPNTPNKLIDFLNNFEIKNMISDIESVGNESCVDSTQKIFEIDFSENHEERLNDMLAKTKKYAATADNLENLSRFKKKEISQFIHSRYKNYFQEYSMTRFKNSNITVLKRLKHMQTKYNSILEHLNIFEKMSLNNRKKYISNSISSITEKIHLNMKVKIGGKSILYIKHVIFIIEKNLKNIFMKEEIFNSNNVAPARKSAYTITNLELMISDKIMGFKKNDINISYIIDSCNFFVEYERILHENMNITILYEDLLLLKIKEELSKLKECVKKNIFYEISKFIELYEQNLEFHIKKRHFYSTIFLLSALVIKFDNINKMESTSGSEENIDASSSDIIALDVFLIGAIFEKLLRNLNNHDMKANCYGMLNTCRLFLNFINYRNKKRTLLFLQIPCFIAMVIDEAFEFDEIQFKEFLAFNLFLMKETSYANHDFLNDKIQYFWEINASVIDNIIIHNLFIIGKAKIISKKNSRLDILAKNLRDFFNGSVPSEKNMSFKCLQLKKLYVSQLYRMLILKERCILYQIEDSTSYRFFPRYEKKINELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M142</accession>
    <name>A0A4Q9M142_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative iron hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0116p0010</name>
        <name evidence="5" type="ORF">CWI38_0083p0060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000116">
        <property type="protein sequence ID" value="TBU04577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M142"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M142"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0116p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0060"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="3">
        <location>
            <begin position="99"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="371" mass="43744" checksum="8DD3BEB69FBE191B" modified="2019-07-31" version="1">MSFNFDKKILNNSKTCVKLDKEIEISLDDCISCSGCLSSTDEAFGSTYSLNLLLDDFPKDIAIIISSVSKTNLYILYKKYFGTFTDFERALINFIRITFQPQKIYDLSYFQETQLCMAYKEFINRKNMLISSFCPGSTLYIEKKAPELLENLSKVFTLQQMSYLHNKALNTTTLSIVHCYDKKLENNRDNIKIEHIISTKEFIKILRHYKFDDYILDDSNNKNDEIQKNEISYKMYEGTVYSFIDYFISKINPTKTSENIINKEFIEYFIEKEEIKYKFLKIYRLNNIVNFLNKYKNAKSTYDYVEMYACVGSCSGGSVLEDGEMDIRMINNEFEFLTEKVLHNSMDLLLFSGKREFTAFKKKNYNFIVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M181</accession>
    <name>A0A4Q9M181_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0315p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="PITK01000315">
        <property type="protein sequence ID" value="TBU15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M181"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M181"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0315p0010"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="40834" checksum="D34BD2F0E4351FEC" modified="2019-07-31" version="1">MARDTKTCFLFDVDGTLTPSRQKITPEVLNMLKDIKSKVYIAFVGGSDINKQIEQVGDDCLKIFDFGFPENGVAFYEGTNLVEQTKIIDVLGEELYKKFVNYCLSYFSKIDIPIKRGTFIEYRNSMINLCPIGRSCSKEERKEFKKFDDVHLVRQKMVDALQKEFGKYNLQFSIGGEISIDCFPKGWDKTYCIQHLEKKNIKNIYFFGDMTHPGGNDYEIFVDKRVVGIKVEGPSDTVKKVYEKIKEKELFYSKGVDNCFYLLNITTNEFENPFLTRKSSRVPLDALKKDCNITEKPLRCKFSSLNTLLFLKIYTGKNNQDLPDLIQKPKCNSINITKKGLNGRLAKVGIIGKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M182</accession>
    <name>A0A4Q9M182_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0073p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000073">
        <property type="protein sequence ID" value="TBU20419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M182"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0073p0010"/>
    <dbReference type="OrthoDB" id="2196131at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="343"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="721" mass="85092" checksum="769A7094CE300CE4" modified="2019-07-31" version="1">MVNRLENQIAENMKRITLSILKRPDYIDSNDYVYVYNNIYKHCTAITDDYEIQGKPIYDLLQEIINEHTSRIEQLISLERFIDVMKQYEMSINVLKSLYSYLSRYFIKISLDRRDGYIQDIETLGYSFFYRNYLESIEKTLLEMIYFEFDIVRTYKKVKNTKLKLSIDYYRKLLAFSDEDSKFNIFKINYLNNLFKKIDFNDNISNISKIIVKEMLIINKIFELEVFYELISKLISKFEERGPELINFVIETMDINKSTPSLYHVIKFLGDKNLKLFFIKYSEKIEISAKICETLEDFLNCFIINNSHIDKSFEADSKLKKKLIEIFTVILKVKNQTKKALISDGKFSKDFMDEIVEEINLIMNLEEKDYKKLDALLLFLKILDEKEISKYKIIDGIQKRLLFNKSELKAENIFIDLLKTRIGSDYIGRLTKSIKDIETNYSNKIAVKIGESCNQISYYRNAEADSNIKFVDEKNECNQKNKKIKSYMMPNLVLENNENLENSCFLLNIKILTKGFWNILPEQTILAEPLQKILNENIQSHLLKNPRCVLEFNFTLSVIEIEFKNFNIKLSTDLASILLFIENNGNLNFTELKMLSNDQNLKNNLEKLLNTNLIKYDSGNYLINYDFDSNESNLNLFEENYTSFNKTSDKIIENFKSSKVMILQAKIVKKLKIEKKILQEELLKYFISNQTEDAILLDAAIKELTDKEYVKISDGFIIYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M1</accession>
    <name>A0A4Q9M1M1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0146p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000146">
        <property type="protein sequence ID" value="TBU20027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1M1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0146p0020"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14433" checksum="7FAF0620F0D1BF7D" modified="2019-07-31" version="1" fragment="single">MERKVLPDTVYPINYDLHITTEPDTLTYTGWESIDVQITQPTNQLFINSCDIEIVYAKVFINNNFIDALIEYDVKEEKAILKFPQTIEPSIIKLEISFTGTLKTNMNGFYVSNYTIKDKKSILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M210</accession>
    <name>A0A4Q9M210_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0117p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000117">
        <property type="protein sequence ID" value="TBU20187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M210"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0117p0040"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="2"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="98"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="57914" checksum="D2F6EF2E8F31354F" modified="2019-07-31" version="1">MNVLIIGCGGIGCELLKQLYLSNFKRITLVDNDTISFSNLNRQFFFTRKDINKYKSEICKKKFIKKFPDAEISVIKNSILDYNLEFFLQFDVVFNCLDNIEARSYVSMRCVFGNVLLIDGGTNGLKGQSEVYGKIGCFDCVEKEVIEYPVCSIKTNPTKYEHCVVWAKEYFFKEVFSNKIFDKNTLLKIITNQNTENISEDTFPEFGEPNDSKKIESSENILGGKFSESEEPTNSKKMKIESTENISADTFPEFCEPTNSKKMKIESTENISDGKFYKYEEPNNSKKIKKNTEKLYKNLYKNNQSDCKKLIDTVNHLLKNKISDFDKDNQKIIDFIYYSAKLRSKYFNINSKDEFETKSIAGNIIPAVCTTNSIISSLMMFSLKSKMNYYIVGNRKLISKVNCYQNKECICTYKKAIIFGDKIKISMIIKKINELFEINDLKIYDGDYLLYDKYFKDFLENEIEFQENKFLVVKNCQTGVLLYTKNGGKFDIREVEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M285</accession>
    <name>A0A4Q9M285_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0021p0150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M285"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0150"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="438" mass="53375" checksum="4362EC72A2922A85" modified="2019-07-31" version="1">MGSIKVIMKLFRIYLFAVYLFVELSVGKMDLTKKEKYFSRKCHSLYTIETMKFEYLPKAIDFTYFILYPTISIHAFESISSYLQSGISTKYELVFYHPYRNYVGNSFEIIFQNFELNRINNEFWSFSKYNKSGFLNMEIRREKYKIFRKEFLKYFLKLFFSIFKVVNRLFTYSNLNGIEFPNITINDITNGISKEIPAYYQKIPNFSIFNQNSYVCLKIFSENVDLNTRIDREKIVEQFNLLFNEFPSKVCFGMYINFLTNMSQSEIHKAPDTTMESCKTIINDYRIIFSDSHILENIEGKISVAKRLFNFEKSDYTFKYEHFFTSNKLQRSDYKFYILFQRNTKIFEFNYKWYNSCDFNQQNNYSSFYIAVYISFDIYLIEFKEYKNQRYFHITKVESSNHRIKYFDNDKLYYKRNVVEISRFLDKIIFYQRDEYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F3</accession>
    <name>A0A4Q9M2F3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0008p0130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2F3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0130"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="60"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="7">
        <location>
            <begin position="229"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="582" mass="65120" checksum="D5F8DDE81E8168C3" modified="2019-07-31" version="1">MLDNNIFLLLIIVIILFLTLNNTNNTTNNSNTTPSTNDLTYNNILHLPLKEGKETESVFSDTFLTNTSLAVNALDNLEARMYVDKRCITNKIPLFESGTLGTKGNVQVVIPYKTESYSSSRDPLDKSIPFCTIRNFPHRIEHTIYNFEERIISISEYIKCNMLEGDSMDRGNNYKGDSYKDNKQDPVNNSLTLYTLLIIVLINKTLLILSLLITPHILLSSVAIGEDIRVLVSSIPKNIYECVREDVILFNKYFYINIKTLIETFPVGHVTGEGQPFWVPPKRPPVPLIFNKDDCLHVLFVQSYCRVICSVYGIKGLESEGEGNGAGVSYKEVKNIIIEWMYDKGILEGVNDKGSKVKGVNDMGSKIKGYEQHPFNHQPNTLHTNTPSNNNTDNIIALHPVTLEKDNDSNGHIDFIYACANLRAHNYNTKEVSKLTVKGIAGRIIQAIATTTSVISGLCVLEMIRYVLYGNGYKNWYFNLGLSFIGCTDVIEAEKMECGMVRCDSRERGVNDTDRSEEGVSNSNRLEGVSNRDRLEGVSISNGLEGVSNRDRLEGVSDSNGLKGVNYSTNTLHPNNTTTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K2</accession>
    <name>A0A4Q9M2K2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="62" mass="7204" checksum="6CB33A2CD227CE0A" modified="2019-07-31" version="1">MVTIRDTVVFCTFYDNERFKNNLEKFISELCFKKEGDGVIYCGVECPFYIDGYNFPEVSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N9</accession>
    <name>A0A4Q9M2N9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0069p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="44727" checksum="3FFFD59F583EFE1C" modified="2019-07-31" version="1">MESSEIKKSNDTGSILKDVVMKYIDSVMFCILVILHICNNFYPSVSKTFKIQNFIGFYTTLYIITSVITRFIDISVLFYEKKESKFRRPNLIKYGVFSIATAISAFLVYYSYQIPPNTENASLKIAAISTFVFNIYDLISRSGNLTKQDCLFNLIYFLCISSAIVLNTYGKNYMTLIVLVAMICKICEIVLSRIQKKKENVLNVYFTAMSISFAVVTAGLIVYSCYKKIPYLIPVLAKAPTYVIFKKISFDRRRGIELRLNAEECINNQNTLEASKYEEYGIKILKPKNNILFIKDGRTTLEEPKININNESDSKKDSDVLKKVHEEPTPPLKEEKREEDGAKNLKQKNNTPLISQGGTTLEELTNNNNKESDLEEETIVVKEVEENIKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P8</accession>
    <name>A0A4Q9M2P8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Swi5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1340p0030</name>
        <name evidence="5" type="ORF">CWI38_0068p0070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001340">
        <property type="protein sequence ID" value="TBT99451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2P8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1340p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0070"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="14272" checksum="2CA212AA0B7BA185" modified="2019-07-31" version="1">MDLELNNWEKEKIIHKNKILNFEFLNKNNFITEIKDSYFYLSVEYEKVEEYFYKEKCDEIINRLNIKDPNMEIKEFIAKLNLYNELKDIAQAMMGKIADFKGSTLKEMHELFSVNDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3K8</accession>
    <name>A0A4Q9M3K8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0092p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3K8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3K8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0030"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="529" mass="58352" checksum="A52F5A66A0E000CD" modified="2019-07-31" version="1">MNVHECKDTREGKPHILQNINTITNLASHLKTTLGPFGMDKLINDLLTNDGATILKNIVRDNEPICKILLSAVNSLDKEVGDGTTSTTLLSSQILSLLKPLVLENYPISTILECLSQARNDILKHLDSLKQKVDSSLLYKIAETSLTSKILKYHKKHFGEIVVKAMSRPNIDSVYADSNINLDSDFYKQSVVIPNISIKKVTGGSLQDSCLVNGVAFAKTFTYAGYEQQPKKIKNPNILCLNVELELKPEKDNCEFKIDSVSSYKDMLEGEYKVFLNRLDTIRQTGANVVLSTLSIGDYATQYFARHNIFCCGRVSEEDVKRVVECCGGEIISSIESLRNKNNETQIQRFIGKCEYFEEKQVGKSRYNFFEGCEFAATLLLRGPTSEMLDEVERSVMDAIGVVKAGLTSKGIVWGGGSCEMSISRFLRDQGIKRGDSCIFVYMVLAQAFEIIPFTLALNSGNDGVEVLGLLRGEHNEGKHSAGVGGDMSLLGVVEPVELKEGIVRCAFSVVETVLRIDGTVVAKGKEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M460</accession>
    <name>A0A4Q9M460_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0009p0040</name>
        <name evidence="3" type="ORF">CWI38_0090p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000009">
        <property type="protein sequence ID" value="TBU05479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000090">
        <property type="protein sequence ID" value="TBU20316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0009p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0090p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036357711" evidence="1">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="443" mass="52826" checksum="ABF5693B7CEEAB12" modified="2019-07-31" version="1">MDLWIGKLQILMLIFYMSTMLTTNDDKYTVCDFDEQLTHVANFFYVKTKEILKKFADSDFYDVKLQERHLAPEINEAICNFVNSSTSTNFNIFFDSDCKIVRSKKNPDILHLLELRKIGKGNFFFEIKSIDRNNKELCYRQRHIVFGNKFLKHLLKNIFNTTLIFRKFYINLMGGLVSSCRYSHSNYRFIIFDPEISFEHVIGLPNKRLAFYSSKNVIAFKSTVATKLKLSGKLPVISDAQDLNLILKEKCKIFQQLNQEYSIKACWRCRNIYKEDIDYNTSNLLHSFYSIITFRTDCIKEFSDNCNNDSLSSNLIKNEYFIEYKATYDAPIESLNFRKEIRIDFSLHKKPYVFTLFLKEHTQFEKKFSLNFSLFSSDEFFEILSDYNLNVTNMVDKVAKFEKFFYNFPLENSSVYQYEYFVKNLCKELYRRMLMDKLAIIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M467</accession>
    <name>A0A4Q9M467_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0057p0120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M467"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="26013" checksum="2947C6D87385B073" modified="2019-07-31" version="1">MVGVNNTDSDQGRVEDINKGVNNKGNNSKRLKGGNTNNNNKSVNKGKGEGVNNNTNEQQGVNNNTNKQQGVNNNTYKQNPVSNLSNDNPFITNGLKDKLNVLNIDNFKEFIYFYTLLIRVPLPFIFIPECSIKEVQDCLSVFECNSIGMCDKGVIICEPYVMNSLGFGFMVDSVIYMEGVVSVLFGGVSVLFGGVSVLFICRGVIYIGSIIKVHKGVLIINLVNKRGGQAIVIFKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4P4</accession>
    <name>A0A4Q9M4P4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0005p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4P4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4P4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0040"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="18423" checksum="1B68EECE02AC2939" modified="2019-07-31" version="1">MEEDIDFYMEEAFKEAQKALLKKEVPIGAVIVRKHKIIARGHNLTNETNNPLSHAEINALRCLNNDFENLTFYITCEPCIMCMDILYKTQSKFYYGCNNYIFGGNTVLGMNIFRSLNGYLYEMSKCISILKEFYNFENENSPEEKRKKKFKKVLQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4V7</accession>
    <name>A0A4Q9M4V7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0046p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4V7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="7935" checksum="4A38D67C22EC4308" modified="2019-07-31" version="1">MYKHDTDLKNTLKNTNSVYEAYSKLILSVLMYISDIKPTNINTDIIHPEIYSESLSFSCLHLITAIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M550</accession>
    <name>A0A4Q9M550_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0032p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36574" checksum="99470E7E2D2277BB" modified="2019-07-31" version="1" fragment="single">WKKSKEISTRRAAILKYRLVEEVTKKSLEESQLAKLFNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLFLLNRYKFESSKRIRSHSVQEILDNEYAEIRVDTRIKTDITLIEVGITSQESLQIVETEKLRKYNLLANELGLIYKFNVEIIPYGMTWDCITVETISFDRRRRLESELNAKRARRVQLTPSFKQVSREEDGAKHLKGKNDTPLISERGTTNKEPTININDESYLEEETKVVKTVEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5K5</accession>
    <name>A0A4Q9M5K5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0018p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5K5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="11667" checksum="3C99ED987F86C86C" modified="2019-07-31" version="1">MNPDIIRLFVSRIGGQKSIDWIGKNFLSSISVFPKIILSISFTNDKNVTRDFKIFFKAIILGHIDFFKCEALQLEFIYNKNHTLLEGFDFEIKKLTKFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUL9</accession>
    <name>A0A4V2JUL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ring finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_0927p0010</name>
        <name evidence="14" type="ORF">CWI38_1081p0020</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000927">
        <property type="protein sequence ID" value="TBU00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001081">
        <property type="protein sequence ID" value="TBU11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUL9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0927p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1081p0020"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044602">
        <property type="entry name" value="ATL10/ATL72-79-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905:SF7">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU00692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="245" mass="28591" checksum="D13611D7FBE10E83" modified="2019-07-31" version="1">MESPIQDIRAQRVSRILDRLSALQCIKWLVVAILIFKGCQIFYNSGVLLYTKDQKCKAPLKLFLGVYTALICIQAMLFFVKNREYFTVDRIPDIQDNNEVGLFTNFVDAFTLFWYLTGFHWTQECKTCKITNPLLYYTSVVWIYYGMLIVVSPLIAIVILILLITYIKPKLPVIEYKDNGEIRKQDANCSICLNDYNTNDKIKVLPCNHHFHQTCIDEWFNVDDICPLCKKPINLLYDLVEQHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVH4</accession>
    <name>A0A4V2JVH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0189p0050</name>
        <name evidence="7" type="ORF">CWI38_0183p0010</name>
        <name evidence="6" type="ORF">CWI38_1320p0030</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000189">
        <property type="protein sequence ID" value="TBU04062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001320">
        <property type="protein sequence ID" value="TBU11211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000183">
        <property type="protein sequence ID" value="TBU19866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVH4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0189p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0183p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1320p0030"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="140" mass="15645" checksum="6DD2DEBC14C5DB6E" modified="2019-07-31" version="1">MLGYYCAAKLKRNRKTKRKADIAYRRRMLPNRHLKSIVGGAPQANGIVLEKIGVEAKQPNSAIRKAVRVQLIKNSKKVTAFVPYDGSLNYIECNDIVTIEGFGKQGRSKGDIPGIRFKVSKVQNVSLMAIFKGKKDKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW16</accession>
    <name>A0A4V2JW16_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2620p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002620">
        <property type="protein sequence ID" value="TBU06202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW16"/>
    <dbReference type="STRING" id="1176355.A0A4V2JW16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2620p0010"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU06202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="25420" checksum="722615A861A957A1" modified="2019-07-31" version="1">MLEDSFIQTSDYFYLLLTVKILLLVSALLFKIHTLGPALSATITYIWTRRNPTTQVQLLGCVIFPAFYLPFIVPIFTFLTDRKINMEDLLGIFVGHFYYFFKFVFPKFGFNVLKTPFFIQKIFNEQPFEEIKKGDLVGDNKEDEGGVNHKEEEEGVSHKEDEEGVSHKEEEEGVSHKDGLSNEEGVSNEEGFNKEDTFSNEEGVNNSNSNSGASTEDNSTDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX74</accession>
    <name>A0A4V2JX74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1594p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001594">
        <property type="protein sequence ID" value="TBU10712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1594p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8835" checksum="04BF33F53A1857A2" modified="2019-07-31" version="1">MECNQLSYGILNFLTHLKYVFDEKASMGVIMRAEMHEEPTPPLKEEKREEDGAKNLKPKNNIPFISQVNHFRGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN3</accession>
    <name>A0A4V2JXN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_0187p0020</name>
        <name evidence="16" type="ORF">CWI38_0589p0010</name>
        <name evidence="15" type="ORF">CWI38_0751p0010</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="PITJ01000187">
        <property type="protein sequence ID" value="TBU04069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000751">
        <property type="protein sequence ID" value="TBU12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000589">
        <property type="protein sequence ID" value="TBU12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0187p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0589p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0751p0010"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU04069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="249" mass="28737" checksum="EC79C0A3CEC93E99" modified="2019-07-31" version="1">MARDTKTCFLFDVDGTLTPSRQKITPEVLNMLKDIKSKVYIAFVGGSDINKQIEQVGDDCLKIFDFGFPENGVAFYEGTNLVEQTKIIDVLGEELYKKFVNYCLSYFSKIDIPIKRGTFIEYRNSMINLCPIGRSCSKEERKEFKKFDDVHLVRQKMVDALQKEFGKYNLQFSIGGEISIDCFPKGWDKTYCIQHLEKKNIKNIYFFGDMTHPGGNDYEIFVDKRVVGIKVEGPSDTVKKVYEKIKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ7</accession>
    <name>A0A4V2JXQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0658p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000658">
        <property type="protein sequence ID" value="TBU12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0658p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16324" checksum="DDB1F29428936471" modified="2019-07-31" version="1">MFDQRKDIEAVSNKLFDKNEETNVEIMFDQRKDIEAVSNKLLKENKINIDLGNEKILVEREVSKEMEEETDNGSNTNQKTRVVRKTALKKEISKNSKSKNSLPKISKSKSVNSTPKKNIKTEVKMVSARKSKKTCDFSLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM3</accession>
    <name>A0A4V6MVM3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0779p0060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM3"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0060"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="295" mass="34631" checksum="D5D27A1D51507B5E" modified="2019-07-31" version="1">MYHSFKRNTNISKYFQQQKTVNFGIPSLDNLINGNIQEGSLILIKEDKDSKLHLFIQNIFIAECISNEYEVSIFSRDVEFPCIPDKITENELINEKEEKMVFAWRYNHLNPPITKMKYDLTKKMNLNDKKNLKIFYDTKLLTSTILENIKNVNRNSVISIYSFLSPLWFHFDKISDEEIYKFLFSLRKTIKETKSVCLVSIPSFFKENIHFNLYFDIIFNLKSFLFTNICPNYSCILNIEKMVPPFGLKENDLDSLKYGILIKRNNMVVEKVVLPPEDIVGVETTSCSTNITNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KQ08</accession>
    <name>A0A4Q9KQ08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2780p0010</name>
        <name evidence="5" type="ORF">CWI38_0404p0010</name>
        <name evidence="4" type="ORF">CWI38_1261p0010</name>
        <name evidence="3" type="ORF">CWI38_1279p0020</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002780">
        <property type="protein sequence ID" value="TBT96727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001279">
        <property type="protein sequence ID" value="TBU11297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001261">
        <property type="protein sequence ID" value="TBU11334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000404">
        <property type="protein sequence ID" value="TBU13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KQ08"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KQ08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2780p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0404p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1261p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1279p0020"/>
    <dbReference type="OrthoDB" id="2191729at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT96727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="136" mass="14718" checksum="32324E1D01885A88" modified="2019-07-31" version="1">MKKTVAEKRPATKAPAKSVSHDSQGAAEPKKKKRGHKTDYHGVIFRSSVKRISKVLYAEPPQISSSALECFSCIALDIVESISDCAAGLAKKVNKQTVGADDIIAAFDICYRGELAQQTLVEVKELVAKSQMKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXI4</accession>
    <name>A0A4Q9KXI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1267p0020</name>
        <name evidence="5" type="ORF">CWI38_0679p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001267">
        <property type="protein sequence ID" value="TBT99648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000679">
        <property type="protein sequence ID" value="TBU12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXI4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1267p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0679p0020"/>
    <dbReference type="OrthoDB" id="2193290at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="156" mass="18507" checksum="D9A577695858DC0B" modified="2019-07-31" version="1">MEYENKIVFEHTSIKNILEMIKIDKLIYPLKYRKTFYGQLCNSQVKHGYLFLLDQNYIGCCSYEIDKECSNAYIMTFGIVNTFRRKGIGKICLEKLEKKLLNEFGIPIFRLHVQTSNSEALSFYKKNGYEVIKIEESYYRNILPKSAYFLEKSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1P0</accession>
    <name>A0A4Q9L1P0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0224p0040</name>
        <name evidence="9" type="ORF">CWI37_0748p0010</name>
        <name evidence="12" type="ORF">CWI38_0065p0010</name>
        <name evidence="11" type="ORF">CWI38_0483p0030</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000748">
        <property type="protein sequence ID" value="TBU01294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000224">
        <property type="protein sequence ID" value="TBU03837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000483">
        <property type="protein sequence ID" value="TBU13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1P0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1P0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0224p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0748p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0483p0030"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="277"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU01294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="434" mass="49812" checksum="4972C58034E681F2" modified="2019-07-31" version="1">MNTEKIYNTLPSPSNYIFLLFWIPFLLYMSYLIADDYLIEVLSAISKKYEINSDMAGILLLNIGNGIPDLITSVVALKVDPYIALCISLGSFVFLMTVVLGGVVMFCRRNEKICYRTFYKNVFFTFIAFVFILYIIAMQKIDIKVCIGMLVSYIVFLLYSFYNSRYASDVIEEINVPQVNLQRKKIKYLFDRFSRPFKFFLDIILLNTLPKPNYTPIIPKYILGFLSPMINFFLLLILMNLKMNLARFISIMALSCLSGLILGFLINKSPENTIFPLYTFLFSCIWIFVVSNELISVINVMDQTLGINKNIAALTLIAWANCIGDLVTGIVSSNNGMYRTAVNATMAAPVHNVLFNLGLIFTVLLARSEERELDFYIYKDISLVGLSFIPITLLIQIFNYEARNKKLCIEFSFVLFFVYVWFLSLTFIDAVTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA85</accession>
    <name>A0A4Q9LA85_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0168p0020</name>
        <name evidence="10" type="ORF">CWI38_0382p0020</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="PITJ01000168">
        <property type="protein sequence ID" value="TBU04215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA85"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LA85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0168p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0020"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU04215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="214" mass="24567" checksum="6633901F94877DA9" modified="2019-07-31" version="1">MEIKTDENINEIIDIIYEKYITKQKYIGIGTGRTIEILINHLKNKNIENILFIPTSLSTMHILNLNKFKISQINLYNTVDLYIDGADYYNKDIGLIKGKGGALTMEKLLAKMSTIFVAVIQKEKIKETFDDLYVPIEILPEAFSYIVSILEKEKIIYSLRQGTGKYGPTITENGNLIFDVKYNLEFLKECKKITGIVEHGLFLKTEFNIKIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCX9</accession>
    <name>A0A4Q9LCX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit Rpb2 of DNA-directed RNA polymerase II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Subunit Rpb8 of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0609p0020</name>
        <name evidence="5" type="ORF">CWI38_2717p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000609">
        <property type="protein sequence ID" value="TBU01875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002717">
        <property type="protein sequence ID" value="TBU05728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCX9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0609p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2717p0010"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU01875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU05728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="124" mass="14113" checksum="A8FDBC31B5C9C9CB" modified="2019-07-31" version="1">MEVLTDKFIVKEKDKEGKKFDNVSRITLVSKDTSLTLDYNSHLFKVNIDDLLEVTLYEGINDDSLIPTDYVYVMQGKVYQVDERDSFVVINASFGGLCMILSILQDKARNISEFSDIVIGLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEY3</accession>
    <name>A0A4Q9LEY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2729p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002729">
        <property type="protein sequence ID" value="TBU05661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2729p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="23093" checksum="763CF5B50756EFDB" modified="2019-07-31" version="1" fragment="single">MDRQRKKMILIIASISILLIISIIGILIYKNSVKEKKGDTEKSETEKTSENLKSGEKETPVMKSSKETTQVEKNMGSKRKLNPLNKVLPSKYTQKPGQNIPPEHKVSLEEVPSGTEQTPPGGKIPTKTEKTPPGGNIIPTKTEKTPPGGNIIPTKTEKTPPGGNIIPTKTEKTPPGGNIIPTKTEKTPPGGNIIPTKTEKTPPGGNIIPTKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIW7</accession>
    <name>A0A4Q9LIW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-alpha-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1914p0010</name>
        <name evidence="5" type="ORF">CWI38_2398p0010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002398">
        <property type="protein sequence ID" value="TBU07445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001914">
        <property type="protein sequence ID" value="TBU10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIW7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1914p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2398p0010"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU07445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17827" checksum="8B18CDDC9D3DDD32" modified="2019-07-31" version="1">MDVTYSSLTNYMDLKQIYMLFCETLSEPYSYFTFVSFYIKYRKFCFVAYSDNKIVGAIICKLENDESGYMGMLAVDKKYRRVGIGKCLTQMAVNNFKENGIYLIYLETEAVNYISLNFYEKIGFRKVMFIENYYLNLNDAYRLCLDNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL19</accession>
    <name>A0A4Q9LL19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2312p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002312">
        <property type="protein sequence ID" value="TBU08051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2312p0010"/>
    <dbReference type="OrthoDB" id="2189352at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="37668" checksum="7BF44A3391326F28" modified="2019-07-31" version="1" fragment="single">KILEKGLKNEFISNSIIKIVYDLLTNEIHVDGLIKIFVNKIGGKKIVSHFVCYKLTELVKMNKNKENRNKILNEIYEYFSRDTVLKARVKILKIIRNLKFDEQEGIIIRKILNIIFSEISTYKTEKSELLSCYINMGIEIYEKIEKDFENSDLEDDFILEISLSNCNSIKNLIHILYKTKSKKLSEYFTMVFRNNIINNYEKVPEILNILLNFLLNENDIKIRKKVMINSLKYIVMNGDIRMILSILIILAVIVEKFGNEILYDNFAIQVLSRHYYKPIQYLFCKIMNTERIEIFDPYDEFSLKNTENIISSINKVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLC6</accession>
    <name>A0A4Q9LLC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2283p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002283">
        <property type="protein sequence ID" value="TBU08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2283p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="406" mass="46493" checksum="CF5A34B6BAAB3877" modified="2019-07-31" version="1">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEMQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADQKEWPRIVFLQMPRNGWTELHRYYNEKFGCTETHEVLKKLAQSEMGKEVKSEVNGDRRRIATCLADTCTLTDTAEYINLRDKFLSKIKEISMKEIGKVVVRTREHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETESFKKIMREFNLNLSCNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP68</accession>
    <name>A0A4Q9LP68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1997p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001997">
        <property type="protein sequence ID" value="TBU10134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP68"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1997p0010"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="97"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="322" mass="36877" checksum="5F9D5F97A71B1CD2" modified="2019-07-31" version="1" fragment="single">INFSNSTDISVNFMDKKKKRNYILQNCDIICTTLSSSCSDLMVSNSLDFDVVIIDEACQAVETSTLIPFKYSPDKVVLVGDYKQLPPTIISNLLPFEKTLFDRLSKYLPVNLLRMQYRMNPLISKFANSYFYDNNIKNHPSVISRKDLYSKFCKPINFINSFGTEIFDKAFSFLNENEAESVVRLISKFLFVFSGENLNGRIGVITFYKSQSKLIKKKLLKLGKPEILKIVEVNTVDAFQGQEKDVIIVSCVRTRGLGFISDQRRINVALTRAKHALFIFGESKCLEKSPCWKAVVSFYKKSSRFYINSKSFFKTGIICKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU0</accession>
    <name>A0A4Q9LPU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1934p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001934">
        <property type="protein sequence ID" value="TBU10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1934p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="12934" checksum="44D6B348B9B160B1" modified="2019-07-31" version="1" fragment="single">IIPTETEQTPPGGKIPTKTEKTPQGGIIPTKTEKTPPGGIIPTETEKTQPGGIIPTETKPKVPVVKAEPGQTPVAKPHYVPKEVNTRDMLINMQGKVDEILKKLPAQKDEPTSSHSGWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQA1</accession>
    <name>A0A4Q9LQA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1800p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001800">
        <property type="protein sequence ID" value="TBU10387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1800p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="19961" checksum="FC9F5223A191A054" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANDADEVMKSDSEVQKYKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNTLVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQVRWERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH8</accession>
    <name>A0A4Q9LQH8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1647p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001647">
        <property type="protein sequence ID" value="TBU10614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1647p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="49691" checksum="03C5BE8671BC25A5" modified="2019-07-31" version="1">MIVFLLSFIEFVSLSPEYNPMSVFETDFPKTLEITRGNEVKVYIITDKSESYGRSFFRRLGYDDHTKEAVIISKESYIEDSESKTVKTVKNLDHENIEKLYYSTKINGIEYCVFEYIPETLESYCIKNEIKLDGYIFFVKQILDAIYYLFSNGIAYKYFSMDHIRITSDLKIKLVDVLASEFNTSGCSHDFSNDCNVSENYKIYRAPEYFLNSPCKCKVSIWYLGILFSENIKNLSKIDDSNKHGRLYNCWYDFQSILLKFSPLDRPWPLRALLHPIFENLFNFLFCFESIEDFSYNKEGVFIEKNNKTIYYEKENIKFSIFCCCVDQKLVENCIIVSPPDRHYDSCNICRRFPTSRKIKFKIEINEKIIPVQLVSYNIYYELKNLFKIFLTGYKHIKRVNGIPNVFVSKIPRSLSSKSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQI9</accession>
    <name>A0A4Q9LQI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1541p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001541">
        <property type="protein sequence ID" value="TBU10803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQI9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1541p0020"/>
    <dbReference type="OrthoDB" id="2374117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="352" mass="41705" checksum="F9D9F0E4D4C1C1B8" modified="2019-07-31" version="1">MIDKYKVIKEITSGTEGTVFLAIDDTTKCFAIKVYKKSVDIDRLFDLNKYNRSQLKHLNILLPIKYIKTADYTVSIMKYYTYDLFKYKRTFQNLTLYEIRIIMKQILDCVNFLKQKKVLHNDLKIENILINNLDIVIIDFGLACSESYPFRLVNSKITSLEKKEYPYFAPEVLNGELVSHKSDIWCCGVIFYDLICSVSFNPENRMLGSNDPECIQFYESMIHNIPSLRFDADILLLNSFFAKLYSFINCLLEYEDFQIKFGSLDYDIQKKKNRLICKQNNKIIYNFKCFCHNKIFCTYVHKYESLVRRPEIKLIYYIVTDSNGSRLIQHATIDILRILQNIYVEIECFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR35</accession>
    <name>A0A4Q9LR35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1423p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001423">
        <property type="protein sequence ID" value="TBU11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1423p0030"/>
    <dbReference type="OrthoDB" id="2191774at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="886" mass="106190" checksum="5682E85E80688852" modified="2019-07-31" version="1" fragment="single">MSIVRFKAHHFRSPNYRYTSLKQYLKNISNHVLSRIDDFFDSNNPSRTEMSDFFENLQNLFLKASQLMKVMEFKREISESTKKIEFLQQSNERFMISADRLAYIFEEIKMTSSYMFDVKYAIKSIFQPENLLPKVIYDFSSFTSQDFKKRLLEYKKSGQNNFYKQNQPEKKFNYLKFKNGFIDSTDKQNIPINSELCINEMERIDLNKKNFEDKEFYKEEAEQINFNKDSCEISFVDSNKNNFKSIELLIKIYLKKEDISSFDSYFIKDGILFLKGNYLTYKMALCGEINNCEWKLLDIETHLRDKRITNLIVNNINGIELKFEEENKKKKSFNSLILFNKIVDANYEARNSYECIKEYVKGTFNDFFVSSFDFYLHCFIKDIIFYKEIEINGKKKRIESDAISFFENTVKSEIKNTIEKVQENILRRNKDSFKTFQDFNTNLNEITEYYCQNIYKSDFTSLNELYLHIYKTTIERHFYEFFIHLSELKNLEIQKNYSDKQFGDKNIFLKKDENFCCFKIESIEEEIYIKIFCGHKKKETDLLFVTLGPENINYENNFRLKTNSESKISFKNISVLLEKNTDLFLMIYTLYLQFNVEIFLENEILFTIENTINVKIANFIQINSLYINSTEIQIIKNFLDYKKLCNKIIIYSKNKKGINYLEEIDQNIKPKKLGEILIYRYIIDSLITVNNGYFVFTITFENGKINFYSENEIINKCVSCKMEHDVSTLLEYLDAFSLFFILKIPIKNIYCNYITIKFNNFIKDSILMKNENKLEYFDILNLNETHFNLNPENLKSSVLLRKIKVSSNFFNFLPTYSKNFLLINDNSKFNFILNLKEQILKDKIVRMGVFFRNYKNIIFDKWFLKCIMEDLLWEIVLIKINKNIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR66</accession>
    <name>A0A4Q9LR66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1679p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001679">
        <property type="protein sequence ID" value="TBU10566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1679p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="9787" checksum="0B4EC117D2309AF4" modified="2019-07-31" version="1" fragment="single">MEIKGLNKGGVNNIEEYDGNKGGVKNIEEGVNNVEEYYGNKGGVKNIEEHDRNKGGVKNIEEYDLNKGGVNNKEEYDRNKGGVKNIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR94</accession>
    <name>A0A4Q9LR94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1413p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001413">
        <property type="protein sequence ID" value="TBU11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR94"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1413p0010"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="664"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119475" checksum="8AA7DAC9D7777345" modified="2019-07-31" version="1" fragment="single">NLKGVSNMSSNQHPFNNNTNNYHPFNYQSSNQHPLNKTLYEQHPLKNTLYEQNPLNNTLYEQHPFNKLSSNITPPYLLTSYLSYLKVLRLKHLRLNKQYDLFNEEIVEELLNNNFIVLYEQSKYYLTINRKRKALECINRLISILEGVNYKDSNYMGDNYRDSKQQGVNYRDTKQQGVNISTNKQDPVNKSTYKQDPVNISTNTYYPINNSTNTYHPFNDDTITNNNNTSYIYYNKSVLLQTKIKQDTILWNNIHKRMLNSEKMFYLKGKYFYIISPFISLQSYIESVKYGNKYVYETIPVILHIYCEILTGGDMLGVGGVSDSSIGIKGVKTTTSNLKGVSNSTYKQQGVNTTTSNLKGVSNNTSNLKCVNNSTYKQQGVNNNTSNLKGVNNNPNKQHPLNTTTSTLYTFFTDTPISYFLPFYSQILSKLSHTDISIVNNISLLLTRMLNNLPYKCTYNTLISINSTNTDVRKRIDSILKGVNSLCKKVLYDVGVLSKYFVSIGKLKRENIINRCVKGVKGEDMLEGVNNKGIGLEGVNDKGSNIKGVNDNGTHIKGVSNRSTNIKGVNDKSINIKGVNNTTIKQEGVNNTTNLQQGVNNTNIKQHPFNTTHKPNLNLKTTTNHNTLPPNTYSLLKVFPDINTIFPLEAVIPNRKSNIKITGVKDSIYIYNSLQCPKRIELIGENGKIYSIMCKSKDDLRKDKRFMELNELLNTILVRDIRNSKRVYNLDNNINLDNIFNLDNIVNLDSNISKFNLGNIDSIDNIGNIGNNIGNHIGGNNNINNNNNINTNTTYNSYIRTYNVVPIDSSNGILEIVGNLRSFRNICEEYLKERDVILSVIMNKYRSRKKIGIEDFRGVCDEVGRVFYKFVQECTNNYDWYLRLKNFTISYAVMCVVGYFMGLGDRHGENILMDTVTAEAVHVDLSCIFDSGKMLEIREVVPFRLTQNIVSGFGCVGVEGLFRRTMEDVLKCLVCNKELIVSNLLGFVYDPLFEWSRRGGPNKGCNDVISGLFDKLKIKDVNERVNELIEEACDDVNLANMYIGWCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH8</accession>
    <name>A0A4Q9LRH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1170p0030</name>
        <name evidence="2" type="ORF">CWI38_1926p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001170">
        <property type="protein sequence ID" value="TBT99920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001926">
        <property type="protein sequence ID" value="TBU10231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1170p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1926p0030"/>
    <dbReference type="OrthoDB" id="2195708at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="118" mass="13628" checksum="6A357CFE1398310B" modified="2019-07-31" version="1">MKDIFPKIKDLSAIFDSSLIINSSKYPSPKKRLKLCFIAVAGINKIEMFIITVKIRIEQNLYEGYDCSSFCYIIYSAMLTINKRYVVYGKVVGASNPRSVFVEYLKPFDSRELCYKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI8</accession>
    <name>A0A4Q9LRI8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1363p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001363">
        <property type="protein sequence ID" value="TBU11139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1363p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38546" checksum="9A5DCE64F05341E9" modified="2019-07-31" version="1">MKKEPHFYISLDKKIYASTDFINGIINLKISEPLDVQRIELRFYKILYSNYTDLESNLEKSKKIKNLDNEIIYEKRINILDRTSEVKKMFSGHHKFPFKMQVSENDGASNEICQITENINYQIVTKYIFEASLKVFDVYKPILSAKKNLFITEYNDIKQEEITKVEICSCFFIFQKLYFLKTWVDKNIYFSGENIFLRSEINTKKDIKDTINDIEVHLYQCIEANINGKFISHVKFIAKNSENTISSKNSITSKLRIPSIVPSSSYKENNYYVEYFLYIFVKFHRSLPIRIKNKVQISQNRKQELEPQSLPLLDGETYATKFFTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK7</accession>
    <name>A0A4Q9LRK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2021p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002021">
        <property type="protein sequence ID" value="TBU10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2021p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="30152" checksum="3A7C3040F7846743" modified="2019-07-31" version="1" fragment="single">MLIHCIILEGVGVYKYVRVGLQAEEFRQVTISIKLCPPILNAKKVFSVINQPAISLIHFHIGLDDAVRAVLVKHKIHLRPVCKKRLYLPGTELGRGLHSVDKEISTRRAAILKVENNNKTHLALITGFSNVKYRFVEEFTKKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVGQHCNKSGKTVDHQATRCEKMLCHDYTRRHNEVVRCLHLLLLKRYKFKSIKRIRSHSVKEIIDNEYTEIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN4</accession>
    <name>A0A4Q9LRN4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1283p0020</name>
        <name evidence="5" type="ORF">CWI38_1319p0020</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001319">
        <property type="protein sequence ID" value="TBU11213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001283">
        <property type="protein sequence ID" value="TBU11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1283p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1319p0020"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="23779" checksum="7F2BBAAD1F1CED38" modified="2019-07-31" version="1">MGASFYLRELHKKKQSDVMRYLLRLRAWEYRQRPAVHRAMRPTYPEKARKLGYKAKSGIYIFRVRVKRGNAKRVAKKGIINGKPSNQGIQQRKGSKSLQALGEIEVGKKIGNYRILNSYWVAQDWVYKFYEVIMVDPMNQSIRNDPRLNWICKGDKKHREARGLTSATKSSRGLGKGLRFNKTKGGSRKACWKRNNTVSLLKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN7</accession>
    <name>A0A4Q9LRN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein L7a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0671p0030</name>
        <name evidence="5" type="ORF">CWI38_1850p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000671">
        <property type="protein sequence ID" value="TBU01596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001850">
        <property type="protein sequence ID" value="TBU10321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0671p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1850p0010"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU01596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15157" checksum="1328135B4E2E3619" modified="2019-07-31" version="1">MVEEVYAPIIDTQMTLKDALFQVCHVSRAQNKLVRGTRQTIKKILRKEALVVFLTEDSNKNVGELIKALTTKYDIPLLPLEDSTELGKIVGFEKVKLGGETRVAKCSVACVVDYVRNSEGKVFLENTLRDMQAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS4</accession>
    <name>A0A4Q9LRS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1320p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001320">
        <property type="protein sequence ID" value="TBU11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1320p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="22339" checksum="93A65EFC2BC4C362" modified="2019-07-31" version="1">MLEEPTIKDNAESNIEEETMVVKEPSDESVFCYIHDGHVTWSAGGVNQHSHTSRKIWYDEYICSDRVDIILSLQNKFSVSQFQKFLYEIRTDAKIWNNTPNTLRMVGKNMLRGYDLSANKLGLIYKFYVEIVPCVMNWDRIVTKSHKTYFKRLKMPMSIEVYIQLIVIKKIVEEIFFDRPRVSESEPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS10</accession>
    <name>A0A4Q9LS10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1311p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001311">
        <property type="protein sequence ID" value="TBU11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1311p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="457"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1096" mass="126251" checksum="A877641E7B6DFD16" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNEEIKAVNNSEIGLKETKTCDRDVVTISETLPPQPTIHNNTHSPPSTTLYVTPVSLLDSAHPSSCPDSSACGPANTMENLNAPAISEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFEYYNGKFGRTVDIDVLKKLTHNEAEREIRREENGERRRTPTCLAEPCFLTDTTLYMNLREKFLCKIKELSEKEIGDVVVRTRKLPSELVDNKVLELINRITGEYAEFHVPKNVSDAARIIQAAHVCYDEETRKEKPRSAWKENIESKISKLVLSKDLLEKARKLEKLSTSETKKFNLDLSKINDLSEALVKKNEALNVYEKKITMYESRRKFRKENRMFELFRGRFHRGLSERVESEHVVYRDEISEFWSKMWNKNDKVVTYDEYLIPFVSDTQQTTFPSLEEFIDIINCLPNWKAAGIDGIYNFYINKLTGLHKYLYDIVKAICLEGTSKADWYYCRLTYLIPKGTPNTGSDYRPITCMSNLYKLTTKCVTKVVRVEVERRGLLSDNQLGAVRGVQGAKEQALLNIAINKEYGNNLKATWIDVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTIKTDAESHATNHLLFIDDLKLLAKNGTTLEKMTEEVKMFMKNIGLEINKEKSATNDPCCEDTATLLEGIGVHKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLLNYHIGVLRLEPADFLKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENDNKTRLALIKDFLQVKYGMAEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLFLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIISYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS40</accession>
    <name>A0A4Q9LS40_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0616p0030</name>
        <name evidence="9" type="ORF">CWI38_1715p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000616">
        <property type="protein sequence ID" value="TBU01840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001715">
        <property type="protein sequence ID" value="TBU10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS40"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0616p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1715p0020"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU01840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="184" mass="21403" checksum="A4B472EDA0A6E7F2" modified="2019-07-31" version="1">MGTVHSTGENFDEESIRKFSHFDSEDVRRWSISFQKAFPTGYLSQSDLEKLFLTFFPFGSPKKFTAILFTTINISGTEMIDFHELLISFSILTKGSSFEKLRWMFRFYDRDNDGVVSKEEMRIVAQAVYDMVGSTFDLNLDIKEMIDLIFLELENESGFLTFDDFKSLSEKKSKLFKMLTIFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS57</accession>
    <name>A0A4Q9LS57_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1838p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001838">
        <property type="protein sequence ID" value="TBU10340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1838p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26975" checksum="A6BC0EA73956CB65" modified="2019-07-31" version="1">MAKKNAKKDFRKCVEGVITGDEEGFKRLKSKANKYTFWMKEPTKLNKMMSLIVQKYYGISKAYIKEYVKDCEACSRFNSLKIIQPVYINHIIKKYYLFMMDCLINKTLKFVKDSLKFLFDNFKNALLEAFLTDLNIKFIHEMPCNLKAQGQVERINQTIKRWPAKKLNETEFIETVTTTIIADDLGSDSKIRSDVAKHFKKHRERIIESNNSNEFKKDLSIGDQVLKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL4</accession>
    <name>A0A4Q9LSL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_2482p0010</name>
        <name evidence="4" type="ORF">CWI38_1376p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002482">
        <property type="protein sequence ID" value="TBT97128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001376">
        <property type="protein sequence ID" value="TBU11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2482p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1376p0010"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT97128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="200" mass="23095" checksum="B3C1EE32D29E8F76" modified="2019-07-31" version="1">MRSKYKIVFLGTQSVGKTTLISQFVHRHADEKYHPTIGIDFLSTKIDINGKEVKLQLWDTAGQERFNSIIPNYTRDSFIAIVVFDLSNQKSFEQIDHWINDLVRIHDTNNCVKVIIAGNKKDLISEEQRLSFSSLGNQKAQEHKGKYVETSAMKYEDIYELVKTVNDYIFEDIQRSDSVIDLNKESEVINLEATRKGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN8</accession>
    <name>A0A4Q9LSN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative subunit beta of AP-4 vesicle coat complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1121p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001121">
        <property type="protein sequence ID" value="TBU11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1121p0020"/>
    <dbReference type="OrthoDB" id="2192743at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="773"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="990" mass="116027" checksum="E814ECC82F9C7B88" modified="2019-07-31" version="1">MLLKNSTLKDVTNKLISRQEFIEYKKLPEQLNQTPDKEITVQINKNLASKNMQKVKKAMQTIICLANQNYNMSFLFPHIVPLTDSTDPFLKLLTNIYLITYSQSNAAILLLSVNTLLKDLYDTDILIKQMAIATTGYFTDTAILSYFIQPLIKNSKHFSPEIRSSIAQVLQKYFFIHPETFYKNTSLGDILVQMCYDKEPIVRYNSLTTLLHIEPKYKVLPNHEIFHLLYMAHNLYFHRDNTSCIELISNTKYLKASILILLNFIYNRKETFELNEMKIVKETLTKFLCLSDTEISIITSEILLYLHLNDQTYLTEKSDTCNQDITTTKIINNTIYVLFSLSEKDQQIDLEILKVLHRTIKNIYVKNTNTKEFITETENTKDIKNKIPEGINISDYLLINIEDFYEIIKEKLEILSLLQNFKKHENLSKIFQANNILTNEILFLYKRNDLSLLCLEILISHCICLEEVFIYCLTTHPKESLNLLLPRFPFNQSFSVFIEKVLANFIRICNGMHYSTPTSTYTSIYTKFITNQSFIIKNVLFLYSNVKTHIKSDLETDTEIEEMIESYESIEDESIKHALVKYYVCMFIKGILDRNKIEEKLKFIGREYKRVNELCGTILKVLKEKNTLEGFKDWVEFTNTNYIDKDIIKETNNHNFKDKNMTNKNSTDKKEINMNTIRDYNEDIKKDAIRDTNKDNNEEMTSNINEFSHPNYLKREKIERFIICNPNKVSCKEVSTEETPVKESILEKLTNFKISSALEIKKRYKEYIPSEISTKNKSPSDKESSKEDIKSPDECQNSQITPTIDPNTSTPIKDKKHKDKFITVLNTPLVTSKLIIRNKVLYLLIEGVNEPFDISYYINSNTIESYRISTPQLLKVIQYSYEVLFQEILFTVTSKDSGVPVNYRYGIIPIEYLIIPHKVSIEYFTDKYNTLPYYSVLSYNNLSKYKKDFYFIDDNTFCFKVFKDEFYGKTHSNQVILKGSNKKLVKIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX2</accession>
    <name>A0A4Q9LSX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1136p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001136">
        <property type="protein sequence ID" value="TBU11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1136p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="374" mass="43012" checksum="D8390E619A06A40E" modified="2019-07-31" version="1">MEDNTLLGNTEDNTPLINNIEGNTPLNNTTDDNTPLNNTTEDNTPLNNINNTKTLLDKNLTNNTPNSLIYTLICSIEINILKTVCYNTIIYFITLNNTIKVDNSIYHMNVKCSDIYFYEYEGVIYVGIKNDCQFSFYREEDINKCFKKGLGNEDIVDNNIEDHICDGKGDNNIEDHICDGKGDNNIEDHICDGKGDNNIEDHICDGKGDNNIDDHICDGKGDNNIEDHICDGIGDNNIDEENKINSFFSVNEMEFKERNEDLMDLCENVERLESTANRYGKEASDLKERMKKNGNQIFYTLGTNFTIINNFMQTVKDLNELMKESVEYGWNIFFLLNDNTIYKFSVEEINVMDNENLQDLLEVYYHKIPKNDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT07</accession>
    <name>A0A4Q9LT07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1288p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001288">
        <property type="protein sequence ID" value="TBU11276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1288p0030"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="258" mass="30133" checksum="DC443C3D06346CE9" modified="2019-07-31" version="1">MLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKQIRSHLVQEILDNEYAEIRVDTRIKTDVKIRYNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSGEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILRAEMHKQLIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPSTNTNEELELEEEIEVVEMVGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI2</accession>
    <name>A0A4Q9LTI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0975p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000975">
        <property type="protein sequence ID" value="TBU11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0975p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="10915" checksum="19525D3B16724F27" modified="2019-07-31" version="1">MTNEKGYVPIWSGHPDPFPVSLSVSLFNDSYKATLGNISQEFLEGKVEVSVIPLIFQEKLGVGLKTHVLKPPCTKPRKVNEPTGKRPDKACMSCSPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV5</accession>
    <name>A0A4Q9LTV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1437p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001437">
        <property type="protein sequence ID" value="TBU11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1437p0010"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="359" mass="41305" checksum="3185165A35F43A04" modified="2019-07-31" version="1" fragment="single">EGSSIRPFNYTDEYLKGVNNEGSSIRPFNYTDEYLKGVNNEGSSIRPFNYTDEYLKGVNNEGSSIRPFNYSDTKYEYLKGVNNEGSSIRPFNYSDSKYEYLKGVKAEDDRDNETSDSGNLEENNKKFTYLKLSDLIRGINGHKRGINIKKRSKSGYNISNNTVKSDNYMNNPNKNRKRLEEGVNNKDFINRKINGNREPVIDNGNKEGVKYLDIIRRRFNSNKEPVIDKPITEGVNYKDYREDTGNREPVIDNGNKEGVNYKDFRNRRFNEEKEGENMEKSNSEECNEAEDKDECIKKEDGLEIGSALHIGEGNKEVEGDGVQYMLLSDIMRRRGIKESGDEDEDSENAQSLDEDEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU74</accession>
    <name>A0A4Q9LU74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0855p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000855">
        <property type="protein sequence ID" value="TBU12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0855p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="47356" checksum="2388F700F9104EBC" modified="2019-07-31" version="1">MNKKRIKTCNIFIKRESIYSDLLHFEISKIGKGGMTSHYGKKYHKNPENLKLRILLRHMKSPVRISPESLNSIQEKIFDFYDCFRYHMKEYDFFNPTSSDDREIFLFFYKAYILKKPFDEFILEYLQEKDPEIPEKNLKVFINLIKNIFISTEINDYTYDSIEYNGMLSEKYFKNNNSVKSMINYYENSYLSLNFWNDISLFKSQKFLESCKIKISNLINEILRELKIPGNLKQDILSIFHIFWELERVLHFFRDYGFYNFILYSLIYVYEKKCLNLDFNNLYIVVDNYLRRFLYKKEISISLKTLYYSLFKINVDFYLKKRINYLNRFGFYTENVHNIYKKHFHNIFSDKVNNLPFKIAISPKSLNKKSKEKNSYFSKRRLFFKKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM7</accession>
    <name>A0A4Q9LUM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1189p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001189">
        <property type="protein sequence ID" value="TBU11471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1189p0010"/>
    <dbReference type="OrthoDB" id="6818577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="13636" checksum="A7EE6737EF11F3DD" modified="2019-07-31" version="1">MKNRQYLEQRKVGLKIFLLTDVLPNINCEEDLEVILKYQDNIQTDGEDTIQNEHFDVSTSQHNEEKLFKPSYDLNDIEREIKILMPSDYLASEHENGLNVSYDLFFGNPDLKKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ1</accession>
    <name>A0A4Q9LUQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0909p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000909">
        <property type="protein sequence ID" value="TBU12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0909p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20636" checksum="530A0931CEB94F63" modified="2019-07-31" version="1" fragment="single">MLLQLLDCLEKSKEISTRRAAILKVENNNITHLSLIKGFLKVKYSLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNKAVFCYIQDRNVFWGADGVCQHCNQSKKTVDDLATRYEKMLVHDYTRRHNEVVRCIHLLLLNKYKFKSSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV1</accession>
    <name>A0A4Q9LUV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1243p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001243">
        <property type="protein sequence ID" value="TBU11370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1243p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="43488" checksum="4EAC01F04F8D3AE1" modified="2019-07-31" version="1">MDEITIETIVKRGNLAKTEEVIQTAGDSENSTMKEEFRKSDSSEAKQVAQIILDSNEEEDISKIKNDFPKSGINIVGSVDNRGNQDARDYRNIKDITSAMDFCALKSQSSSETIPTSFSGGLKDETSRQASSREIDPNSITIGENIPGMGKLSSNYSPPGKYMPVAEVNQSGNTLPKQKRVFPQQPHFKMLESSNYSVSAFDLNYSPWQSNDAHPLIEFSGLPLVKFPGVKYEGNSNLTFSQELSPRSELEYESSMNLPNFSEPLQLFEPNFERRDADESVVINSQIYSKSSKYIYLDIYLIFFTSCLLCGISISNYNHLNDLFLATSLLAILFLIIFSCNILVTESNLKNKDKIFHFINSITSFTTIAIILTFTLGVFQKFWLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV08</accession>
    <name>A0A4Q9LV08_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0732p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000732">
        <property type="protein sequence ID" value="TBU12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0732p0020"/>
    <dbReference type="OrthoDB" id="2191416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13100" checksum="CE9ABE895F719996" modified="2019-07-31" version="1" fragment="single">EDLKILKNEPKVSNNDIKDSGTEISEMNDESKNIKSEIESKVNEVSKKMKKIVSVKTKVKGKNKEVKILRKIKKSENDHIEQPQFLVCRICNIIFPSRKDLLQHVTSIHNSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV93</accession>
    <name>A0A4Q9LV93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0814p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000814">
        <property type="protein sequence ID" value="TBU12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV93"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0814p0020"/>
    <dbReference type="OrthoDB" id="10614411at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="20833" checksum="CECC07E74175C5E4" modified="2019-07-31" version="1" fragment="single">PPPPPPPPPPPPPPSYPPPSYPPPYYPPTPYVPPFIPVVPEFSGGGSGGGSGGGGSGGGGSGGGGSGGGGTGGGSGGGTGGGAIECEISAGGGGAVGKPLPAAPVIMPPQPKPTVIQRPSTQPMILQYGSSPQVSGMQGQQSSGATECICEPQGSQQQTGLMTVGAINCADQSNSDVKACEEGTSMATTTIGNVEVPVAPTFVTQKPYEFSSTCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI2</accession>
    <name>A0A4Q9LVI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0777p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000777">
        <property type="protein sequence ID" value="TBU12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0777p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="28070" checksum="93F281B6B5068919" modified="2019-07-31" version="1">MKFWRNKFFKICSIIVLIVFIFVAIICITGYRKANALVENFQTDVNDSSETDLFKKLLGVLKNYKICVFIKTVYGPNTAFYIPVFRNHNEVKKYLFKAITNKDEKQFKSVKSSADIYLCGSVDLENFSVPEDIDSITKIGLWFKNKQVQKTIEEIRDHIRNVLNETKENQLNIVYLNIANDETVEVYNVSASYKTDQIYFLSFKSFEFTLETKSTEELLDYMTFFILKVTGGRFKDTNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV2</accession>
    <name>A0A4Q9LVV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0607p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000607">
        <property type="protein sequence ID" value="TBU12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0607p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="53521" checksum="875C15FED547C201" modified="2019-07-31" version="1">MDILPLILVPYKYNYYIKNLDPKNEMKDVILSSPLTLCQGVHELAVVSDGEVVLYTKDDKIGTLTYSDLEYFSFEIKTIKSTVKEMALTFINSYALDLLVFSFKNVYFLLGRYETNIVYFNCCFYLNKTVKYSEIRNIFLCPKNIFLEYQFIETTKEEEMEIFPNGNEFIENPTDLLNKAKNNSEIDENTKDIKIEINTKKTNEEDSDLFDVEMKRIEENESEEYLMKEIEHLKLKRQINNESELKTSYDTKNENLKSEDEKEMKSLVSDRIKKLNAKNTNENVKTKSNESIKSSENINENENIPNDLSNIKNEDNKPKEHLNAKIDEEINVTRNRNVTQETENKPLNVIEHTVKFGKILDKKIYFVKKELQKSFSFDNLPHLKSFIIISILNMSINKYDYFEVRSDTEMFIFKENNSFLLFIYDKVSGEEKNIFEILVNLPTEIEKELKRVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW56</accession>
    <name>A0A4Q9LW56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0571p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000571">
        <property type="protein sequence ID" value="TBU12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW56"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0571p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="631" mass="71282" checksum="4704107B8F846B93" modified="2019-07-31" version="1">MNLEWRNVDIELVNKNKNVKGEYVRLISNSSGNVKSGSLCAIMGPSGSGKTTLIKALTGRIPSGSKTRGKILVDGKQRKYETWSKNIGYVDQDDCIFENLTVFETISYAAQFRLKDKNIDINEKIEKLLEELEISDISGSKMISVSGGERKRVMIAIELVTDPKILFLDEPTSGLDSSTSFNLLRLLNDLSKSHNTTIIFTIHQPSVEIFNTFDQLVLLSDSHTVYSDEAQKAQEYFESYGLKKRELSTFPDFLSEILKVKKKYKELPENQAIIAKMVNDNQKNFSQSDAGCFSSSNTLAVEIRPSLGHIYILLKRRCKLYLTFMKIFITLLIFGALTFIYIYFNQVIIAEVPKLKDQINFALSVATAGNDAPILEIFRQGFSAKFDIIKEVLVCIISVSLLSTLFGYLMIPSTGAFGYEYKITKREMGVATYSIGSYYSSVFIFEFLIYFPLLICSSICAKIFISEVIKWETYFYILGALIGYLPTILFFGSCTTRTKTIYAVLSCLAFTWAVPGYIFAVWNFCAIKTESFISRTIAVLISIFPPVQYNCLLIGITYKIRSAACKGLQADSKLKNSFDYFAKVLYSLIFESLEVWQACLIFIVSTLVFTSISILALCLRLKPEMRYKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW95</accession>
    <name>A0A4Q9LW95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Subunit alpha of sodium/potassium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0561p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW95"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0010"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="11">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="11">
        <location>
            <begin position="383"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="563" mass="63581" checksum="BB7327DB4E3148AD" modified="2019-07-31" version="1" fragment="single">SNGHRVIGMAYKIINKKEYLSKMKKVKKSTNNENTNDLSVNLNKHNFGINPKDLTFLCTIGILDPPKKGVKDAITQLRKAGIQVVMVTGDHHLTAESIARKITLVSGKTKEQTASLLNIPIKDVKEDQYDVEIISGTEIDDLSDRDWNIILSKREIIFARTSPKQKLKIVEKFQEKGHIVGVSGDGVNDSPALKKAHLGISMNKTASDVSKEAAKMIILDDNFPSIVNGVLEGRLIFSNLKKSIRYILSHITPQVIPFLLFVAFGVPSPMSSLLLMLIDLFTEFLPAVSLAFEPPEGNLMHDPPRKLLIRNIDNINNTTTANTLNNKNTDISDTNPEASNNPNTILEINTEPSLLVRRNILAEKVFLFSFFRKIKNIFLKKETGETLCDIDLLSWAYLEAGTLITLGCLTSFFITLYLSNVPITYFFMSSQDYFKLESKNIFLENGISLNSEVQLDILYRAQSSYFFSILISQAFNLLTCKRKNEYLGISTFRNMLPIYGTLIGLLFGISILYIPAFNYLLLSRPVSFLPFVFPVLFGFIILIWDNIRKYIRKNYNMYGSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB7</accession>
    <name>A0A4Q9LWB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0980p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000980">
        <property type="protein sequence ID" value="TBU11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0980p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="800" mass="94458" checksum="F7C9B09753A32389" modified="2019-07-31" version="1">MNNIMYPKKKRAFKGYEFCIQYFILKIFMTLNLVTAYKFAFNFYKNENSEILFFLQRQENRENSEHNIEKFDLKSYNTNEENQFDRQDPVFTYTKENFIEFYLLNNMLFTNSFENNCQNRIINCNFDLSYCLKLSKDFTVIPNRLTICQLKYFLLTLKFLQAVDNKNMAKLLQALIFKVFICSNTDKNNTKHEEIIDSNFMSQFDFYIKRGLLIAFLNILMINYTFYDENLILLEKSKDIYYTSHFNEHIPYKNLLINNYKIFRTLKNTLKGLPNFLCIFQILLDEINIKSLIINNYEELENHIEDVYLFISSLTFFKSIVVLNSKNNSRGFLYDPNSINKKDIEYLSLKNLTIELSNLVFLLEQQKLKGLILNCIDIEGVVDNSVESNMKLNLEYIHLINVKMKVFKWCDFFKSANVHKIILNFSGTKIQESILNELIHDNSCKDVLYLEISFGSTGIWSNLHVLLKNFIYLHTFKLESYVSDENIALSLVKTVDNMKGLENLTINLPQKGMAEYAFIFKMPSIKFLCVSVGRSVYASRGKISININFLGNYKSLNEFVLMNAKIDESEFAEIFKLEALTKLSFFSCDLDYISNYSTRDFFPQNITSLDIVRSNLTFFKNFDILSIFTRLENLNIAKCDLESGFLAKLNPLCNFSLKKLHYLENCLDKNDLDRIQNLKCLEELYLKDSKFYQCSFSELGNDCKFLNSLKVLDIQYVQIYLEDLIYLKRFKILKDLKLTLSTSDFFTTINFLRSLPIYILSLDNFEKGNLDRYRYSYSYECYFYEENIKNSNIVLTYLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ0</accession>
    <name>A0A4Q9LWJ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0970p0020</name>
        <name evidence="4" type="ORF">CWI38_0940p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000970">
        <property type="protein sequence ID" value="TBU00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000940">
        <property type="protein sequence ID" value="TBU12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0970p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0940p0030"/>
    <dbReference type="OrthoDB" id="2195547at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37176" checksum="4A27D82BB3179313" modified="2019-07-31" version="1">MERLPSILQKQFPSILSAAIALSNTLNSALYLEHHGIVMEFPHTVVSTFFVFFLPPLIANTVYSQFMVTSILLMCFGFGILIFPYFKNLQFMFGITHIFSLVGRVLLLLDMKNSRKGTFTQMFMWLLIVDFVGMAVKKYFIRDRSRRIDEKEMFKLMCEVTVLYVFRKLRYSDSGMAACILVVNTWYPLKEVLCKIYDRRNKNEEEEIKNVEIKEKRGEKTKRGSKEKRGVSKRVSEGEDSEGEKKGTKEKRGVSKRVSEGEDSEGEKKGRKKKGSSEEEKKGRRVSGGGTPVRKAALEAKLNSTSPRRRTPRKSAKKIEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL5</accession>
    <name>A0A4Q9LWL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0516p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000516">
        <property type="protein sequence ID" value="TBU13149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0516p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020666415" evidence="2">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="25733" checksum="CB474A660BEC6DC6" modified="2019-07-31" version="1">MYLFGFYLSFLLLNIHFSMPRYGKIYRNRHRNYRYSPGGSDIRNQEVGHNLLQSNSRDSNSQDASSRLYTLSLNNIEETYSRTDMNHSDDTLSTTSHVSSTSVQDDTEEVEIRTSDTGQSSQSSSLVLEDSQQPEPTTAFPILISILQSVEPIPIRPISEQPSSSQHFPEQPIQSQQFSNASQPDILWEIITAPLQQQFSADLIIQNNEVSSSTPEYFSMSNLTPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW8</accession>
    <name>A0A4Q9LWW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0622p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000622">
        <property type="protein sequence ID" value="TBU12807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0622p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1844"/>
            <end position="1865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1865" mass="221313" checksum="77EFB8D93FDAE1BB" modified="2019-07-31" version="1">MQSKEEKLLETIIDDYKFHTPELQDFDGCVYEFENEILETQPTLRGFEFIKNLVDNVDAFYEENSDNLCSDLSKMFESEDLPKKIQKMQYNGTEKADASVINNRKYYPSYILYKECIERVEKLICKKTVKQTINNVNIYYGNLLSKEKDFKLQENNEVFLENSIENKETEDKKTDNHFILTKLENKEVFLENSIENKETEDKKTNNHFILTKLENKEELRKSENNFFHTKLENKEEEVRKEDNYVILRKLENLLENNGEISLDLKNFYLNEIESNPNDLNISKSLIAILFFRISDSLIKPEIIYKVLENLEKNIKSISLNSNENKFLEKILKNLEFLYSKKKDDKIFIEKTWNFLVSIISIACNTNECIKILSLNFIIELCKSSFELTKTILDVIVMEYSSINNFTICKLPFKDFLILKIIETRFFKNNKIMEDELNYIMNVLFNRITFKEKFIDQNNLIENEKLFISDNFDIYEFLKNIICVFDTNCFSRIIIFYFLNIFLSNFMYFIENRNNQSKIFDIFDIYFEKSFLMIKNEKKNLRNNFTVEEEIFYCYILKTEGICETIQYFSTRLVLLLTSFIKKRICLIKSFRSLSKGCQIRFLTFTDRIYIIGVLIKFINKSENNKFKENINQEENVSKNSISSENSKKNNSYNILLEYTFDILESLNYKKLFEFIMNIRNSNIGTNLLKKIFKKLLIYLMERKNCSLIFEWYFDCLSDTKKRKTVLKSLKLKKILKDFTTLKIFTAVYISHDFKNIVKYFELPIYEIILFLKTHTFNLSYLVKRYSKYHSNEFSIYLPEIINIFETRIKVIEKKHIGYYNNIIGILINIFSQNNINFCFKAKLKIYLEEMIFIEPFTKKCGILLNILGFHKEFYNFYFKKYNISPNRRDFLVLCSIGDKRFKDKIQNSMFGLVLYLNLYPNEIIIYEKCIRLFLDKMEKSIKIEDEIYFIYLLKILKRELKKSLNHQINEKNFKNISKSNKTLKTERNIILNQQKDFKNIFLSSNTEEPPSSNEIYFCIISSKMHIFKNLLIKSTPLSHICFQLLYIGLISGAILPQMIISEFLFYCCIFFKKNTIKDITVRYGKIIITNFKIFISYLNSYFEKRMNFSQNNIFIPIIFQHIKTKKHKILFIDNIFEIIESTDLFTFYFILNNLSNTQFSKKEIYYIIKHCENILETQILCLKKERNYEQLKLLLKFKYLFLFKETLKIKDKRIFDKNLFQIDLNDIFCKETFIKKEYFLSLILSLNENEMQNSEQHLLENSLPSSYTRITHPPASQTCINMQNSGFASLSSSNTPLPSSVEVSACDIADDIRFVTADPKEKLLIVFLQDGWTELNGYYNEKFGCTETLEVLKKLAQIEMGKEVKSEENGERRRIANFLADTCILTDTTEYIYLRDKFLETRKLPKKLVDSKVLDLINRVVATYIMQAAQVYYNEATRKEKPRFARKKNIERKISKLVLSKDLLEKARKQEKLSTSDTKSLRKILRECNLNLSSVTDLSKAEIKRMSRFYGELTERVESEHMVIRNERVSFWPIMRNKNDDTVTYNDYLIPFVSDNHPTMFSSLNEFLNINCQSLECLTSTMLTTNYVTKVVDLEGEKPKVACRKSIKVVRVLSSMSLNEEYDIIRMRPGNNSKQEKSYTKRLNKDTARKESVTIVVCVVYGFVEPHPKLEIDNDADFNTHNHLLFIEKFKLLARQFFLLVIRLDISNEKSTTNDTRYEDTATLLECLDDALYELHVKNNVHAFPEEECQMVLILLRIHASVSFGLPRKSKEISTRQAAILNVENTNKTHLALIKDFLKVKFRLEEEDRSVFRGADRLCQHRVKSSKILDHLVTRCEKTLGLEHKRRHNEKPSFSSRNFENEMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX05</accession>
    <name>A0A4Q9LX05_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0597p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000597">
        <property type="protein sequence ID" value="TBU12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0597p0020"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18445" checksum="F93DFFE1E83658E2" modified="2019-07-31" version="1">MSEINFRKNYTFINNTIFTDNDIPLPVNIDEEILYFTKNVTFYLQIGNGAPALTVRYSSYNGTVYITNYRVIYKPKISTKFFDSFFITFDRIISVDDDYSFDIAIEESYVGSVYIGFEESHKSVFYKVLKSMVNEFTSKEDTQDSEDTLPLYCEAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX52</accession>
    <name>A0A4Q9LX52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0759p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000759">
        <property type="protein sequence ID" value="TBU12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0759p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13793" checksum="F782E6EC3764F46F" modified="2019-07-31" version="1" fragment="single">MTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG3</accession>
    <name>A0A4Q9LXG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0710p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000710">
        <property type="protein sequence ID" value="TBU12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0710p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="30036" checksum="378055F3CCBA2630" modified="2019-07-31" version="1">MTGEAKEFFRYCHSFEGYSVYKYLGIIEDSRGVPTLKRLCHTRSNAIFQLIDMRSQLAGFITFYDAIRAVLIKKKIHLRSGFEKRRYATKTLGCLEKSTEILTRRAEIPHDTMKSVEEAQLNWNVFLRAEGMCHGCGKSRKTVDYLANRFQVILNNEYDLLANELGLIYKCSVKIITYMITWNGIKTVETIFFVRRRGLEELKESVNGYRAKNLKKNNNPFISQGATTFKEPTININEESELEEETTVLKEVVEYPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH8</accession>
    <name>A0A4Q9LXH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0415p0050</name>
        <name evidence="2" type="ORF">CWI38_0437p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000437">
        <property type="protein sequence ID" value="TBU13412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000415">
        <property type="protein sequence ID" value="TBU13493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0415p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0437p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="10653" checksum="44E73674F14C30A3" modified="2019-07-31" version="1">MRFTYDSFIKEENPDKENLDPKRHVYSPRSKKKDVRKRTALRDLSVPNVIDSSDTSVTVPLNYSYSRRVEQLFDSFQSYKLKHKNIREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH9</accession>
    <name>A0A4Q9LXH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0135p0020</name>
        <name evidence="8" type="ORF">CWI38_0377p0030</name>
        <name evidence="7" type="ORF">CWI38_0754p0030</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000135">
        <property type="protein sequence ID" value="TBU04438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000754">
        <property type="protein sequence ID" value="TBU12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000377">
        <property type="protein sequence ID" value="TBU13628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0135p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0377p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0754p0030"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU04438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="125" mass="14711" checksum="34C3408230C75427" modified="2019-07-31" version="1">MNKNYVDDKSEEEIVERTRKRKINTTIELQLHKKKKSSTSLILPATLVETEMVKNISENSTEMICAICKRKLRVSNNFSCRCGGMFCGRHRHFDQHSCTYDIRKDFVEKLTKENPRIIGRKLNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK2</accession>
    <name>A0A4Q9LXK2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0697p0060</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="PITK01000697">
        <property type="protein sequence ID" value="TBU12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0697p0060"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="117"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38697" checksum="DBF6B57D8BEA6735" modified="2019-07-31" version="1" fragment="single">FKERLINREIKKTLNIPCDCKEIQNFKEIFSLKNEIINLNSQISTLKSEIEILEKEKQILKDFSDSLKFRKTDFSFLEKASENELISEIQSLSQGFDDLCTENNKLLEEIDSNIRVKQMLTNEIRTLKNKNEILLLQTENLENERNLNQKKIINFEFQRTQNEKTEKNLKIQIEDLKNDYLERKSAAFFHKRNFIKIYNENSILLSQIDTLKNKFTDLKNKFIQQNETSNKLQSTINILEKDLKNTKNLLLFYFKDSSSEIFNEIEKYKKTIICSACDTNPKNTVIVKCMHVFCKQCLDKRIQLRIRKCPICGESFNINDIKKIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU4</accession>
    <name>A0A4Q9LXU4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0374p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000374">
        <property type="protein sequence ID" value="TBU13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LXU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0374p0020"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1792" mass="213723" checksum="C62D5789E70DA119" modified="2019-07-31" version="1">MNTIRSYKERNTMVKRLISKTIPENLPVESVFYSFNENILQNIGKTSLCRWSTLLKIYEDKLLSYLILHFNKNIQIKPFDITYKHKILYIFKILILIMKYTFGHELYDFNQSIYEYTHSHDLDISYQALLFYNERFIFDEMNAQKCISDILKEHDNSTYLERDYSLTIYEEKNKILVEFAYGNDTDRKILLEIQDLLTKNTKLGVKNNIFEIQNKITNITLKIAEILKFEYYKETESQKLLALDILLTNILNTSFHSFNEKILRYGECSVDNIENQINKILNTRSFCIENIYQKLNLIIQKSIEREILLIDFNETNLNDFIKSLTNLLDTLIFSQKNHLFYRKLIEEESFNLTIINSFRFLETLRFINETRNADFAIKIFVLISKTLIKVLKNEKCFSRDLIDFIVNETLNFSLVQKPEKYKFYETDLFYELFEYYFTDEIPMSSLSFDNIYFLLKKILKVENNEYNLNMVDHIIKFYYYVIEHICNENNRKIVDLELFDIHKSAFYAKIFVKNIHKYFEDKNKFVIDIFFYYEFHLKNLLSFLTNLFNYFDINLTFQNPNCIYLLIKRPEFLFFSEAKWLIWDIVKNITIKTSPSQDVYEFFFKFLEYTLERLSTCSFDKRSCSGVNERELSKITVNKLYEICYISLLGILPRFGFPYTKLLYHILILPDTQNNSITMSKDSEYDPNILYLYYLHMKFNFIALEFFFRTVFDTFHKLSNIALKYSADNKFLEADTDSIIFKSLDLFMFVINNMKDANLLYSSSKYFLQFIEDNIKIFTATIFMDLFTNKILKYLELIAVLCDIRLFDTITSIVHKIDNKSLKSLHTNNKIEKNTLLYDFLYFSFYKMKYSGIFINVNDVYSLYNILISNINTNISKDKKFPYKKETLFGFFDIYNLIIQEDAFIYAISLIRLSEFSNLFTKMELYLNFEFKRVLDIFSDKNDTLDLNANLYNYSYLYLRCMLEDDIYVLHSLMYIIRNYSNLSESVFIYFYSRLIIREKPTNISEFLLDESELDLKRKIIIDVFNIAKNGDGFKQPISLQILTELISTFPPLIYIIDFVDLMNLFSKITVYSVFDDKILLYRLDEEFMSKLVVGIIEKLSTSNIYEIYSIMSFLYKLLLSEICCCGYTQDIFCSAQEFYDSNCEKYFLERRLRIIDKFLTLGLLNMLLSVYKKHEVLYIYTMKIIEFVINLAEDKNYIFKRKFLMNDAFVARSSSKKNIFIPNFLEESVLNTIKQIELDNDGKIKETSVVKIWHNNCSQLDFGYKARNHLPGCNYRFLYIFITSDAKIRISKYNFVIKKFASSDLFINKFGQNFDKLKFMKIISDYDFPDLFLLDLAKEVGLETFILPEPKQNYKFPPEKKYLSKSLTYYFENNTDSSSLLDEDHLISKKPSRFATILTIKQFAEIFLWLLVNNKKIYHTYSIKFLKKIADFCIRNKLIDEFYLILTKNIKSYKSEVKDEITLKKLEIIDIIFEEINFIEIFNSDFLTIEILMVIVKIFTHDNPSVGLTYDFFTLFGRAIDKCLFFESFKNLDFYDMYKLKHEDDQYIKNLYFYTGLIMAKSIMMNATLGFQFIDSFYFYLLKDKFTVEDLKLVDNEFYRNIIKSRDVKNISSLELTFSISFGNSANTLEFIPDGSNISVTNSNIEDYLQIITEFKLFKNMIVYLEELKRGFKGFEKIDVDAWISATKYSKEFHINHKVIIWFWEFIRESCVETQKRILYFVTGLEKIPIGGFDSSKFQRNPFTIESSTSINLLPRSQTCINLLFIPLYEDKETLIDKFLIAIECKEYGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW1</accession>
    <name>A0A4Q9LXW1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0369p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000369">
        <property type="protein sequence ID" value="TBU13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0369p0020"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020510998" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="432" mass="51860" checksum="E4A460E7448CD47D" modified="2019-07-31" version="1">MKIFGWNVIYSLMFLYVVMCTKSKRDHNYVLKKFSKGLSNHGYYSGKFIFAGKYSYVYCFKYVLSEESVGIVIPRKQKHGFRFQNKSDISNIIEHENFWKVKATLQIKRRPCVVMPIYENNLYSYIPTLDVFDVKKKEIIKQILDALAYLHHKDICHNAIDLYNIFIDKNEKIVLTDFRLSYTAYRIRMHVFRSSLEETKVKYCKIWSGIKVKQKHGTKTDMKSFGYLFLSMYRDPKQRRKTEVFNLLDPDFKHFAKYFLRKPRKRLSAYGARFSSFFDEIYDFVFCFCKFNDFDIGSKGFQCKKVESRFSVKGNGKRFSIYCKCSEISKELFEKRKLEIQHQNPYWFDDTEIEKFKFSQASSFAVKTNKIIRLLPELSHSEYQAVRNIFFTFLSERSCYKEPRITPEKIIKENKRKEYGDEGRIPKRIKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY3</accession>
    <name>A0A4Q9LXY3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0490p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000490">
        <property type="protein sequence ID" value="TBU13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0490p0010"/>
    <dbReference type="OrthoDB" id="3349616at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475:SF1">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36363" checksum="3A145FCA5BF47722" modified="2019-07-31" version="1">MFWDGIRLQIPMNTIETISFDRRKGLDVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPFILDGINTAKEPTTIQMKSWMLKWGKELFKKEKFILNCKNRQEKEILTPYLKRGQYPAEYSKEEKRLFRQKAEHFTLLGDDICFKRRDHLIRAVFGFETASIKQIIQTEHAVAHIEVNKMMAFMAYIKGYVKECEAFSKHTTEAFLKDLNIKFIHGMPCNSKAQGQVERINQTIKRWPAEKLNETGEKSTMVPAIYIDPDMVLVEENTADTQWILEIASDLYEEFTETVTTTTTIITDEFEIDSKIRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA7</accession>
    <name>A0A4Q9LYA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0323p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="395" mass="46611" checksum="2AEA2DC61ED6C35B" modified="2019-07-31" version="1">MSNINLKYLMRDDSLFSNLWIISSNYPYLYLLPFHIDLGNVLIYRIFEYKYLHWKITGIILEKTLNEPVSNSKTKNIGMNLDGICLLNLEMNLFQVKIFSLSFTNKYISDKIFFLKISHSKIEYNGLNSLLRIPNLEKLYLYNIQFLGSEDNKIVEKNKSITTFEFERIRMSFFDLVLKFIKSMESLCNLSIRYFLENSIFASHDIKFLEKSEISFYRFINNDEANIGIFLLSVFLVKDSIEFRSNCELGKLKDKFSYDGYRNLKSLKIGSFKINETALNVFENLRSLESIELHPNQHIHINFSELFSSCVIYNLKFIILREMRILNDDMLFLSKSKNLERLIFDKCDFSGLSYLTLVKNNFMSLKILKFLTCHYFSSGGLHEFLNEEYSVNILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK9</accession>
    <name>A0A4Q9LYK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M24 metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0295p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000295">
        <property type="protein sequence ID" value="TBU16694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0295p0010"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="309"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="506"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU16694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="571" mass="65849" checksum="C97A171FB3DD732E" modified="2019-07-31" version="1">MVIYKLLISKDYDGYIINLADEHINEYISPSDNLIEYVTHFTGSNGMALILKNGSSVLYTDSRYFIQAEKELSNDFKLKKMGIDENIYEYVQTIGGIKKIAINYKNISYSRLNDMRSKFEKNGVEIVHDDLTESIWPNKPERTYNEIIDLEKIKANTFLDVNSNENITGSNYMDKINKLREKLSEDQVFILSELDSISWLFNLRGSDIDYNPVFYAYCIVSKDKAVLFIDREIERKDVEIKKYSEFYDFLKGVEATRVFVNSRCNAFIVTELGEKIVEVSDLIGELKSQKNEIELKGFELAHINDGISLCSLFEWMENNIGKTEKEIADKLEEYKRMLPGFISPSFDTISAYGPNAAIVHHRASETVVESKNLFLIDSGSQYLYGTTDVTRTIHLGEPTKEQKHDFTLVLKGQLAAMRQVLPKEKDTSVLDTLARMFLWNEKKDFGHGTGHGVGHFLNVHEAPPGISQKGDLLKENQIFSIEPGFYKENDYGIRIEDLVVVKKDENFFKLENLTMAPLQLKMMDLNILNDDEVNFINEFNKKVRFVLQNKLEKGHGYDFMMRNTEEIKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ75</accession>
    <name>A0A4Q9LZ75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0234p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000234">
        <property type="protein sequence ID" value="TBU18634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0234p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="48044" checksum="28884F8765D3B577" modified="2019-07-31" version="1">MLNIHKKNTTNLLSALQYRLTSPIILYGPPGTGKTHILYKTLHSLKITPLYFPNPSTYTNTLLFTNTIAHTDIDTLEDFNKFLKNNTHPLNIVIETRNLYFLSKCVKGSILVKFLYTTNTLLSKYNLVTPNLHSLSIFEEVSRRGVSEQVCDIKGVNRRVSKRGVSKRCSKRGVSKRSSNNTPLNISNINNTPLNTGNVNNTPLNTGNVNNTPLNILPINNTPLNILPINNTPLNILSCYNTSLSFYHFLGKIFYYDRDRDRDRDRDSDKLKDKDKNKKKENKKFENKKEDKKDEKKDEKDNKEQNPDIIDNPSDNKALQILNNISFFKNKIKDYLFENYLYFTDIREQGVIIDNLSLFDCYSEGVLCNVICVMGIEKLKPKCFYSFKSPYYLKGRGRGGYLKGVNYWYTYVKGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA9</accession>
    <name>A0A4Q9LZA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0532p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000532">
        <property type="protein sequence ID" value="TBU13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0532p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="590" mass="67885" checksum="CCE7EC3CB5A7955E" modified="2019-07-31" version="1" fragment="single">MNPFHSNTSHQPDISTKIKNLKKSSPSLIIETLKSLNQTEIPKAYLPLLIPTLTSIITSSSSEDSVRDTNISEDSVRDSNKNIKNIKDNKNIKNIKDNKNIKNIKDYRNIRDYKNIKDYRNIKDYKNIKDYKNIQNIKDLKTNNNPTTHTTILTNTTTNIPSIQYLSYSLLLKLLRSYNITPFINYLSSIINIHIRYPTDISNIIYKEYLKPNYSFYIYNLIYNLEIEKDILHSLKVFTHVLYILKSKYNIYSDYRGVIGCSSKEGGVSDRGSDYKGVSDRGSDYKGVIGCSSNYKGVNNSTDTYHPVNNTTNTYHPVNNSTDTLHPVNNSTDIYHPVNNSTDTYHPVNNTTNTLHPVNNSTDTYHPVNNTTNTYHPVNNITDTYHPVNNTTYTYHPLSNNNSNNNPLYLYSYIINTLLSNIHIIDFNNTYNIKVISIILSITYIDLYKNIININNKSIYNIKYNLLIDIYNRIDYNMLIRDIKYISSDIVCKIIDSDSIYREGDMLKGDINSRLEGDSNKDWKEGGVNNNTSKQYPVNNLSNTLYPFSNSTNEQHPVNNLSNTLYPFSNSTNEQHPVNNTTNTLYPFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB1</accession>
    <name>A0A4Q9LZB1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0516p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000516">
        <property type="protein sequence ID" value="TBU13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0516p0030"/>
    <dbReference type="OrthoDB" id="2186317at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="30828" checksum="17CCC69C5A06DF1C" modified="2019-07-31" version="1">MIQVFEYYISHHLSKSFESVFGGVTCLPGCFCMYRIKVNEKAGVIPILSNTFIVNAYSTYVAETLHLKNLLYLGEDRYLTTLLLKTFYKRKLVFIPQAKAETLVPGSFGVLLSQRRRWINSTIHNLFELVLVGKLCGTFCCSMQFVVVMELMGTLVLPAAIVFTGVLIASSILIKPEWIPLVMLGGILGLPAILILLTTREISYLFWIVVYIFSLPIWNFVLPVYAFWHFDDFSWGETRKVEGGNKHGETEGVFDSSRIMLKHLEDFEGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ4</accession>
    <name>A0A4Q9LZQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0491p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000491">
        <property type="protein sequence ID" value="TBU13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0491p0040"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="21293" checksum="B16676EAD01C6B77" modified="2019-07-31" version="1">MADSFTELKLFDRYSFSDVTCRDISLAPYINVSPITSVPHASNRYSSQHFGKSKIHITERLACALMRKGRNNGKKRLAMKALEGAFSIISVSTNKNPMQILVDALINCGPREDSARIGRGGAMKRTSVDISPLRRLNLAIFLITKGIRTSAMKSVKTLSEVIADELISASKGAQSSYGVKKRDEIERIAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E0</accession>
    <name>A0A4Q9M0E0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0236p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0080"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="413" mass="48106" checksum="5BA082A05185D551" modified="2019-07-31" version="1">MPKIVSCKNTKEKEILSSYLKTAQYPAEYFKEEKWLLRQKAEHFTSLGDEICFERRDHLIRAVFAVKTALIRQIIRIEHAVAHNGVNKMMDLIVQKYYGIPKAYIKEYVKDCEACYLRRYGDKNDQYSWIINVINKTSELLRDSLKFLFENFGVPVAIQSNNGREFKNTLFEAFLTDHNIKIIHGRPRNPKAQGQVERVNQTIKRWLTKNLHETGGRRWIEHLNNVVWAYNRTIHNSTNKSPFMLFFRQPGFNNPLSRSIIVEKDATMIVPAIDVDSDMVLFEENAGETQWSLEIASDVHEEFTETVTTTIIADDLEIDSKIRSDVAKPLKNYRERIIESINSNRHKKDLSIGNKVLIKKHFDINAKTKRAHFDSFYDNSVFTVTAILMNNMIEGKNNDCGPRTVFRGVIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J1</accession>
    <name>A0A4Q9M0J1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0134p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0100"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="45178" checksum="9D4AB0BB7C5CBDF2" modified="2019-07-31" version="1" fragment="single">VLVKNKIHLRPGCKERLYLPRTELGSGLHSVEFKSEHMLLQLLDCLEKSKETSIRRAAILKYGLEEKVRKKKLEEAQLPNLYNEIKNRKLHSKLYSARNNELVSKGSVRPRDEAVFCYIQDRNVFWGAEGMCQHCNQSRKTVNHLATRCEKMLGHEYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHAVQKILDNEYAEIRVNIRIKTFEMIRCNRPDIFILDMRQKRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRIGHDASLSAILGAEMLTQPTSPLKQLDNKEYGIKTENTKNILLLILDGITTVKEPMININEESDLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U0</accession>
    <name>A0A4Q9M0U0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0356p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000356">
        <property type="protein sequence ID" value="TBU13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0356p0050"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16098" checksum="FF892D9D0016B565" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U7</accession>
    <name>A0A4Q9M0U7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0201p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0020"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11986" checksum="ACB094F718C44970" modified="2019-07-31" version="1">MLTFPGEDTNILLKNGLPIFNLPMPFIGANVTCKIYKVTPFQASARITHIEDQKCYITYRGVFRSLDILANTVEDIYVTDVLKSGQILKALIISYGENNGLILSKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M104</accession>
    <name>A0A4Q9M104_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0087p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M104"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M104"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0070"/>
    <dbReference type="OrthoDB" id="2194813at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="2">
        <location>
            <begin position="167"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="340" mass="39302" checksum="DA13D68FB5165039" modified="2019-07-31" version="1">MIILEQPNDNIFSFILVYGIISKKTIKIEKFKKNNFITSFLNLIEKITVNTKYEIKENFVFYPGDIYGGKDIHDCLVYNISMYIIPLLILAPFTKKEMQITFTGITNNRQTSIDMIRLAYLKVLKDFGVENIEIKILKRGFEPEGKGEVFFRCGNVEFLNNIEKSREEKLIKIRGMVVGSKINSSIPHSLIELIKDGVTNFTENVKVYTDLRTSTSSGPSPGYQLILYAEGKKTFYFSEELGDERLCSSLVTKAIDDLIKSIKNSESYDVKVLPLVFTFLALTSHNVSEIRIRKIGEDCKIILNYLKIFFSYRYSFKREEKNKIINSFGNGYRNIYRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M186</accession>
    <name>A0A4Q9M186_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exopolyphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0407p0020</name>
        <name evidence="6" type="ORF">CWI38_0151p0020</name>
        <name evidence="5" type="ORF">CWI38_0324p0010</name>
        <name evidence="4" type="ORF">CWI38_0573p0020</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000407">
        <property type="protein sequence ID" value="TBU02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000573">
        <property type="protein sequence ID" value="TBU12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000324">
        <property type="protein sequence ID" value="TBU14448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000151">
        <property type="protein sequence ID" value="TBU20012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M186"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M186"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0407p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0151p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0324p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0573p0020"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="2">
        <location>
            <begin position="259"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU14448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="48131" checksum="095C8057678EF935" modified="2019-07-31" version="1">MKMLTQKFKEYFTKNKKRIQHSEVKIAIGNEGCDLDSFVSSLVVGYAEDIIHVVNMKKEVFKCKGELMWVIDKFKIDIEDLIFLERPLGNFKEHIRKAGTSFVVGDKSYRITDKNITLVLTDHNKPIEELNEANVEMIIDHHRLEDKVSEAKRIYIDTDVGSATTLVSKYLGSDLAKKHHCVTHPDGKDNIPLLEDETDPDKDHETLCVSLAKLLLIPIIIDTGHLKRRTSTFDYLEYHRLMKVANLKKKEVKKFRKVIKKVRRNDNEQPTNIILQKDFKIYRSQNFTFGCSTIKYDFEEWAERESKEVKGFNKDRTGMILYLVLENFRREIGLDFLFVGCKLKKKRHFIIVGFPYMSFLKKTYEFVELEYKGLIYYKVPVKLSRKILMPDVKNLVERIKLTEGDSNLSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D8</accession>
    <name>A0A4Q9M1D8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0057p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0040"/>
    <dbReference type="OrthoDB" id="2196308at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020851647" description="Chitinase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="46455" checksum="EA43A9DD5CB7335B" modified="2019-07-31" version="1">MKPILQILNFFLIISLSLAAGEKSSKPFVLATYLDFSKKESKECKGCSLFESGDAYETGYFSKESRTKNTETDKIHERINAKRMHDIDLFRLLSNKLFFIYDVLSFLGASYDIHRRPHGELSITTALRIIYEEMYFKYNEMILFLAHALHNTGNFRHFVNEKDTASGKYKSRGLLQIRGEQNYKLLNEISQNIHTNFEEYPEELGKCDSNAIKVTIGFWNLKVEEWKAKNPCKIFGFKASMDILRPIESSTRSREKARYEERYNAPNDLGHIYKFSVAIIPYVMTWDGIRLQIPMNVAYNLSIVLKKTFETISFDRRKRLEELGESVNGCYYEIRNARGTNTIAKQARNQEDSVKCVKTKNNTPIISERGTTLEEPIININEESDLKEEKMVIVELEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F1</accession>
    <name>A0A4Q9M1F1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0061p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="16966" checksum="B20B1867A6DF6343" modified="2019-07-31" version="1">MIYIVDDFRMNDFKILMRGTTLEEPTNNINEESNLEETKIVVKEAYIQSIVLKKTVETISFDRRRGLYWERASMGVIMRSEVHEEPTPPLKGEKREEDDAKNFKPKNKAPFISQGGTTLEEPTNNLNEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H5</accession>
    <name>A0A4Q9M1H5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0050p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21809" checksum="56367E4621FA66E3" modified="2019-07-31" version="1">MKDVFNHTSTDEDVSIEGNYTKIIKLKEDGIPFVKNRAEKYYYTFDSKRTDKKERITELAKYIHNMFKNLRNFDNMNQNPDSSANDYQKNDVSFDKKNLLNKKIIILLSDSEPGIKDTEKIQRFLQDSNEEENNTLIIYIFENTYTEVSENICTEMSENYVNLYQDRYPTSRLYSNRQIMENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J4</accession>
    <name>A0A4Q9M1J4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0189p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000189">
        <property type="protein sequence ID" value="TBU19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0189p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="14227" checksum="137DE9BF22D1C141" modified="2019-07-31" version="1">MSSCNADTEEGQSDRFNERENNDSLEFVFNNFLSYLFETYFVDIQNVIQCKRNKIIGLVDQKILSTFSKREMHFYEMILKVSRMATKKMRFSLANLLKEILENGIRTMQEDLYEIRRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N2</accession>
    <name>A0A4Q9M1N2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13156" checksum="2B85DD604A4BB7F0" modified="2019-07-31" version="1">MDEINELLISVAEYKLFRFDEIYRLGLNTKYEWNFNVKLKIQPSHNNLASILNVFVYRETVYNEMLLIFSRKASEMNKLELFRLLNGIIAQDIKFMSQNYKKLKELFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V1</accession>
    <name>A0A4Q9M1V1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0039p0050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000039">
        <property type="protein sequence ID" value="TBU20659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0039p0050"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="329" mass="36210" checksum="9D4BFE90A506ABAD" modified="2019-07-31" version="1">MKVGINGFGRIGKIIFKILTKRGIEVPFINDPFVDADYVEYCLKYDSTFGKCNCKIQKKEKSVIVDGKETFIGDFRSPSEIPWNKYNVDGVIEASGVFISLKDCEGHLKSGAKKVIITAPSKDAPMYVYGVNEKEYKNEKIISNASCTTNCLAPLAKLINDKFGIIEGLMTTVHAATATQKVVDGASKKDFRSGRGVMQNIIPASTGAAKAVGSVIPSLNGKLTGMAIRVPVPNVSIVDLTVKTEKSTSLEEIKELIKKESEGELKGIMGFTEDEVVSSDFNGDSRSSIFDYKASIALTPTFFKLLCWYDNEYGYSYRVVDMLEYVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M296</accession>
    <name>A0A4Q9M296_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0045p0030</name>
        <name evidence="10" type="ORF">CWI38_0021p0110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M296"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M296"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0110"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="8">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="275" mass="32254" checksum="017E57EB33573611" modified="2019-07-31" version="1">MENENSINSDPNMSEQIAYDDIQEKYCDILFEMTTKKDEIIENEYKNLDSFLEKSEKLFKRVKMPQEMKLDARVMNVSTKISSATLEKDYRSNNITTSGFIKLYSEHLESENNEFLNFLKKTHKNYLGITFYNYPVLSSETAQNKLRTRATQNYFDNSVPLKPAISTLVDEDEGTLRYIKNVKQILKKHKKISFFELIIDPNSFSKTVENIFYMSFAIKLGAVGLKNYKNDLYIESEISTSLNSLDHFIFDISYDEYLKIVENMKDKTMIKNFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H0</accession>
    <name>A0A4Q9M2H0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0007p0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0110"/>
    <dbReference type="OrthoDB" id="2195577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="396" mass="45662" checksum="12EF0B8625FC3DC5" modified="2019-07-31" version="1">MRRTYKPLHRRESKAFALNKKEIQKDFGKFIKLDEDHLENIDEYWKIAAEELEKSSSVDGFSDCNLNEENKIKEEETPFEQKEDTIYKSEDSEEITGNDIEKQDQENEDINDKSINNISFNSNNSSSIVLNDTNLQEMESDLQLANSSAIPDEKFQNENSENILTTNSEFKENEKNFISKNLQYDLSILETSSETQSEKKDKKIKKSISNFDFTTMKVANFSPNKKNKSIYNLKDEKTRNKKHKKEKKLSVHDKKTSTHKIKSGKHLFEIPSSNNSSIFEQKEIYSSSFTENSKFTVSNIKKLSKRNNTLVPLISTNSLETAIIFMEFGAKIVKEISPQDFSLYIIKGHLKIVNNGIEVDIKKDSICVIERDSVYSVEALGLKGNTFLVSYSIRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2U2</accession>
    <name>A0A4Q9M2U2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0182p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2U2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13999" checksum="8A6CCB102183C21D" modified="2019-07-31" version="1">MTVFSNSVKKRIKEKNNSECLKNEKLNSVNNSKKKIHEIKSGNTDSISKREKTLSPMAIIKLSNYDLKYLLVSKSLSHKNNSDVAQLAELYGKIEKRKFHIKLYSIQKKEVNVSDSTRWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M373</accession>
    <name>A0A4Q9M373_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0066p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000066">
        <property type="protein sequence ID" value="TBU20468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M373"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0066p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="24939" checksum="33D11280303B949C" modified="2019-07-31" version="1">MNTWNFMNRTNSKNIFGSFGVSMLAFLLVTYVRSAERESRREITLLFDRKNLLSAKNKTFVANPIQDAYCSSRSKRSGNYRSDDSSSRYRTESSDEDVGVRHRSTSRALQRSHHEESKPNSKNSYDLLDERISRSKTRIVNIKKRFDRSSSKSLKTKVEERLAHFRKELDCLKREYKDRYLTPDEIRQLENKMDDIENSLFKLEESADKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3M6</accession>
    <name>A0A4Q9M3M6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1753p0020</name>
        <name evidence="13" type="ORF">CWI38_0089p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001753">
        <property type="protein sequence ID" value="TBT98444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000089">
        <property type="protein sequence ID" value="TBU20322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3M6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3M6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1753p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0089p0020"/>
    <dbReference type="OrthoDB" id="2189390at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT98444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="148" mass="16090" checksum="DA00732F2B985D69" modified="2019-07-31" version="1">MSAHLMGSIGIVILVGLSAYAASEGIALSGTSSILYCQRRSIITQSYVALIMASTVFMYAFILAIAIMSAMTKEYTIEIAFQHFGASLIYGLTGLFIGNSMGKISKTSFKVLNQMPSFFFSFVLLIATVEVVLVFSFIFSLILIYKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3N5</accession>
    <name>A0A4Q9M3N5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0088p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3N5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="32580" checksum="A083E3A73C2860CC" modified="2019-07-31" version="1">MNHRKIISPRNSKIPLRLVINRPKERKWYNIKYREAKKFILEKLFFVLYVTIDLIIIYILERFFKKNIQIRLLFFVAMAHIYQKTYDSFIGFDFYKRLIPNDRYKLMMKICMLGTYFLRIFADFPCKNTIPLNLRIHNKYFALALGTIWSIASYLVIYFTMYPLQYFFYDYRNLSGALISFFIFLNFFIIVNSYEMTLLLTNMFIKFEFLTLAPSYLVVGFLFYKDAKFYCANHNYLHYIIYLSVYICLQWPFLVNIFKYLVNINLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3R1</accession>
    <name>A0A4Q9M3R1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0123p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3R1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0070"/>
    <dbReference type="OrthoDB" id="643377at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="765" mass="91209" checksum="0FB7F36F45D2611A" modified="2019-07-31" version="1">MIILSSIYYFLINCKFCRNQTDCLILFCFGVLNTKFIEFYWIENDEYISEDIASKNEIRMVSDDLKAEDNDMKGIKRKTTIENPKTFKRRKLTRNIIVSTVEYFLSIFKKLIIENNDEHYTLKIEVKDFTYEDFNIFLSYYKTFYFPFSNFYLCNFILFLNIFEYLDISIDENFYKIVDLFLFQLCDLVKNKSINLEEEISQQKNKPMFSKHMVKIIFERFYKNYISLKSENLELLENIIKDLLLNKYDVELINSDLGLVSVSDDLIDIFEIILKKNHYCQNMFYLIFSIFDIKKVIFHRLIINLHKINNIVEFVLENIDEVVFYNMLIKDETIEFLNNNLIFNNLKHIHFINTKIISKNTFSDNLLSNKNIQAVIQVLKYKIENNFKENISRLIIQERLTLEKCLHYTFTKNTKLKTVNDLIFFRKEIFKIVIFPKASLSLELLSFIDILPNLKSIEINLSSLKNEITFVDQRYLFKNIIKISFKRCLLTKTILETIVILPDIQILVIEYYEFSFPLNNTIREFDLTHDFINTDTVFLLFLKSFKKIECLSFVGENLFKKLFFNDFTEYISNSELKSFSIISEYCIATNNFSFSCETLQDLQIGNKFTCGTLNSIFSNPKTKGLQKFSIFDCFIDKTDSFAFKNLNNLVDLEIENFNLENIYFHDLFSPETEYVIIELNLSSIKISRNDIQQICKFKHLKRLNLNDCKFEYNTFDSIKRFHLSDMENFNIVYINLEILDLDTNSLIEELGEYFCQFTMQMIGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M400</accession>
    <name>A0A4Q9M400_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0102p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000102">
        <property type="protein sequence ID" value="TBU20256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0102p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12693" checksum="803785CDF1545150" modified="2019-07-31" version="1">MPGAELVWSILCFATPYNYRDIPKEAKARTDLYCQGRINKIYLITDVFIGKITLKTTLFQHLNEYIQKILIKATHSKAYTNKNADKLVSISRPILFYMFFLLEKLVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4H5</accession>
    <name>A0A4Q9M4H5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0068p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0060"/>
    <dbReference type="OrthoDB" id="6493019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="25453" checksum="88A3220E87851794" modified="2019-07-31" version="1">MLGHDYSRRHNEVVRCIHFLLLNKYKFKSSKRIRSHSVQEILDKEYAEIRVDTRIKTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETVKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNTVETISFDRRRGLESVDNEEDDVKMENNKNILPLILEGITTAKEPTTNTNEELEWEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4I5</accession>
    <name>A0A4Q9M4I5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0009p0080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4I5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4I5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0080"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="488" mass="55452" checksum="465BD8C65681FAE2" modified="2019-07-31" version="1">MENDDQHLIKSSLEYQERRKRILLERMKHEINILKSTKDYKATPGNLDQFYRLFERFLKIKDEKIRWDDIKPPPEDKIIMYNDLHDEDPNKSSKLLEKLAVLKLNGGLGTTMGCVGPKSAIKVRNGQNFLDLCVKQIDNLHKEHKVCVPLILMNSFNTEKSTNKMIFRYNGIRTFSQSIFPRISEDSLLPLCTSNADACFYPPGHGDLLQSLKDTGMLDELINEGKEYLFVSNIDNLAATVDFKILEHLIENDIDFLMEVTEKTRADIKGGTLVKYENSLRLLEIAQVPDEKKSEFTSVRKFKIFNTNSVWINLKTVKKVLDSGPLDLDIIVNRKKLPTSGETVIQLETAIGAAIKYFPKAAGMVVPRRRFLPVKTCSDLFLLQSNLFIEREGTLCVNPKRIYLQNPLVKLLGKNFKEVSSFMKSFLTIPDILELDHLTVSGNVRFGKNVVLKGTVIIIANENSSIQIPDGSILEDVIVTGNLPIIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Q8</accession>
    <name>A0A4Q9M4Q8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0027p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Q8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="32489" checksum="32686A4054FB9541" modified="2019-07-31" version="1">MPKQDLQVFKYLKYIKVLKILLLENILICDKKLIFILESTTLISVELSNFIYIFNDELFSKNDTLNYNLKIFKLKNSKFWIEPNLIIFNGHIASENCHSEKFLPNFDFVNQKATTKIFLKNLEITAYFLNNTRIEYYMSFFSGIYDFSKLNSISLNVHKLTDIDYEFFYQMKKLKVIKIHLKSNTDKIDLKNFLKIPIYSIHITPEDIQILNSLKNLLYFTLSTDKIDYKTNRNMRRKNFKTSKFVLLKPCRILRSTIINVHLNSEFRSDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4S6</accession>
    <name>A0A4Q9M4S6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0025p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000025">
        <property type="protein sequence ID" value="TBU20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4S6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4S6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0025p0010"/>
    <dbReference type="OrthoDB" id="3562449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="39484" checksum="9ABC188D7765F161" modified="2019-07-31" version="1">MAHENSKPNPVILISSNSDTNSVTIKKKKGNFEYEKMKPSMIHDYNKYIGGVDECDKMLYVYLDERRTLKYWKKVVFNVFGRMWMYHKNSVSTQLSSSTNKFALEKLPGRNILWGEDGMCQHGGKSGKTVDHLATRLQKILDNEIKTGVKIRNNRPDIYILDKKKNKITHFEEGITSQDSLQICGYNSVCDDRKRIVTKHPKSYLKRLQIPMNSLSVIKRVEFHDEPTHTLKQASIEHDMLKMLNGGIIHSLFQKKNHIRERKSNAFTSLYTDTLNFKPSTSIQESKKHMIRSFAKYMCVIVYLDLAKLMSKGYSRVAELKTSSVHLLGNSLLIFFGICNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4U5</accession>
    <name>A0A4Q9M4U5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0022p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4U5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="749" mass="87676" checksum="B12B8AB982AC054C" modified="2019-07-31" version="1">MFIKVAISSDIWSHLYQHQINGLNLTENSDESYSARIPDSSTYTTRTRYLHSFTNQYKASNRFSPYNILPSLHTLSRYRNYHYPCCTFPPFDFPSHSYTINSSHGFASTKYQQDTLRRDFNSVPYSTFQTSNSEIKGNENSTNQDLHIDNTDSANINDVVESITDKNTELKTSREDIVSNNAENSIIEERNLDLRVYMNNTRYSDNFQGSDSDPLLQNSSEGQAIISNAETTATCVNTNATQNISVMNPSAEPSEKEWNNMIAKTVKYVASADHSELLWRVKLEDRNKMIVENYKTYIREFSMTLFKKTSMKTLDKLKLMQCEYENILKLLIGSETWNLPQRNGMLANILSDNKTNLLNCESLIDTKETQIPLDLIIWNMNIILQNFFNKEKTPISQTESSFLNLTYSAHELEHMFADAIKVIEKCDTEITEVYKICCAFVDYEKKLFGDMSKHEIVASLKIPTIAETFSKLKRCMELNKVYEISVFIELHTKDPIRFLKQHYLVSTVFLLNALLIYLNEIDYRELYVHSDKKNYMHKRSEMSKKAFYIGQLFERLQRNIEGNDLKADFYGVLNCFRYHFKANTRQGNRNTLLLVQIPTLIAMVVDKSFCFTEKHFKELASFILYSIKNKDCGCSEFYNDKFEYFLEKNLSSFGSIYKHVKSFVKDYKGVARRNSKIIKMSWAFQNILKNLSVECEKQLNKNIQLKRLYILQLYWISTFQYKCLAFYANHDNFCMMVSNIHRRIELYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4W8</accession>
    <name>A0A4Q9M4W8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0044p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4W8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020265470" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10729" checksum="701007ECE2FCD61E" modified="2019-07-31" version="1">MYLFFVFLCVYNIQGTFVDGYTVTRGGEFVGLNLQLRGNGFGHVYSVREMREYVPFYKLISVNSEINTENGSRFEDMFKNVKNAINNKNVCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5I4</accession>
    <name>A0A4Q9M5I4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0001p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5I4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5I4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0030"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU21032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="46738" checksum="B90BB38A0D8BC0EA" modified="2019-07-31" version="1">MEIKEKNKISIRNALNIALDEEMDRDERVFVIGEEVGIMGGAYKVTRDLQVKYGCHRVLDAPISEMGFTGLAIGSCWGGLRPVVDFMTMNFALQAIDQIINSAAKTLYMSGGRIKSPIVFRGPNGFAYGVGAQHTQDFCNYYGSVPGLKVVAPYTAKDHRGLLKSAIRDENPVVFLENEILYNYDFDRCESFENPEYLQPLDKAVIEIQGSDITLIGISISMLICQEASQILKEEGISCELINLISIRPIDIETLIKSVTKTRYLCVVDYTWPSFSTASEISAQINEKCFHVLKSPVLRINGEDIPTPYAENLEKMSFPTVEKNDRRRGLESGLNAEESWERASMGVIMRSEMHDEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEEKIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUD7</accession>
    <name>A0A4V2JUD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1198p0020</name>
        <name evidence="7" type="ORF">CWI38_1043p0040</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001198">
        <property type="protein sequence ID" value="TBT99841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001043">
        <property type="protein sequence ID" value="TBU11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUD7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1198p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1043p0040"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT99841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="184" mass="21564" checksum="1EB6CEAB8B7AB63C" modified="2019-07-31" version="1">MGFILSRFYYGKEKKILILGLDNTGKTSILRILEKISISKDEKEITDDTLIVPTIGFNTETIMYNDKTFTVWDLSGNVNVRNFWRCYFMNTKYVIYVIDSNDIARKEIYLSVLIQLSQEVELIRCSFLILLNKSELNMHISIDEIEEIIKKSYSKRKIAVFSCTTRKKESIIEAFDWLIKDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWR7</accession>
    <name>A0A4V2JWR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2225p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002225">
        <property type="protein sequence ID" value="TBU08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2225p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6628" checksum="5157E8F1CB4FE165" modified="2019-07-31" version="1">MKIKTQGFKNAYEALLLKIDELIQKKDSQLAEMIERIEFEVVKIVERVENEEAFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX13</accession>
    <name>A0A4V2JX13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2064p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002064">
        <property type="protein sequence ID" value="TBU10052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2064p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="778" mass="89924" checksum="D3F16CA9ABFA99F8" modified="2019-07-31" version="1" fragment="single">HLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLRKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMREEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKESLKSNEDNHNKASSSFMTRESIEVDEILQSNEDNQNKTPSLLSEAKGFEVKENSPDTINTGILRGLDSREAIYTSQISDKTNPLLFDKNSGIHSVSNFDSISSDEPIATYSNISCKRRRLDKKPNAKIHYGTRNERQSTVGNSIQPKVDIKPNAHNGDTHNKNTEPNRNHETATKKYDNTLTMTEEPKQQSYIDKNSHILKEEEPIDILKKYICKILDDKIFFEQLKEKINVGIRYNNVLNALTVPINYRVASDALENKPAHIYNKECSAFASFREHLTNLTKTYLNNVDLDQALSILSPEKFDYGKFNSILSEYKALICRITFTNEIDILSLFECFEKLVEFENIYVGLTPQNKTSSLLSQIGFSTEPQLEISKEIYNFINKHEKVENILSSIKRNRLLQLNFLVCLFNCLSKKLSQDIIGLGNENRTDLFQESEKKDNKLILENVLLLRKILLRIFLCLKDYDSITAIYSLLIWFDYVLEKNKLFFSEEYCEIKEFINFCFETIMTNKMAQNNRFLMEVLSFITIVISKNSILKAPANIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB8</accession>
    <name>A0A4V2JXB8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1319p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001319">
        <property type="protein sequence ID" value="TBU11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1319p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="43555" checksum="E8958F2AAE2489B6" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISNRRAAIHKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLNLLLLNRYKFKSLKRIRSHSYPEIRVDIRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLDNEVGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKSREIPMIVQAGIQFIVLKKPVETISFDRRRGLESGLNVEESWERASMGVIMRAEMHEEPTPPLKGDKREEDDAKNFKPKNNAPFILQGGTTLEEPTNNINEESDLEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI0</accession>
    <name>A0A4V2JXI0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0989p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000989">
        <property type="protein sequence ID" value="TBU11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0989p0020"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="224"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="392" mass="44873" checksum="D0D4F279DCF8F787" modified="2019-07-31" version="1">MIKVLKEMNYDEPTQIQKKTIPVILKKKDILAISKTGTGKTLAFVIPIINSLLKKPRSFHSIIMTPTRELALQIKEVLISLGCSFGIEVALLIGGDDMVIQTMNINRKPHVIVGTPGRIVDHLDRTKKFCLSKTKMLVLDEADKLLEMDFENEIKRIKDEINEETQILLFSATMTKKVENISKITLNQPSIIQLSSKYDTVDLLQQKYLFLPLKFKETFLYFILVENKLKKIIIFVNSCSNCKIISKMLEELNFDCVSLFGEMKQEKRTEALNIFKSKDTNILVSTDVSSRGMDIPEVECVLNYDVPENGKDYIHRIGRTARAGAGGLALTFVTQYDLEKYQKIEHIISKRLESYNLNRTAAETHHEKISKLIKTIYIELKDLKNGKKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI8</accession>
    <name>A0A4V2JXI8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0939p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000939">
        <property type="protein sequence ID" value="TBU12012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0939p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="538"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="648" mass="74790" checksum="CFFD88DFB1476D42" modified="2019-07-31" version="1" fragment="single">KNTNSDTTTLYETTQITHINNTLTSSRNKTTGKILSRLRVVRTWLSNRKVSLKRSLETTNSEKGEDQIQYSKEERINEAEKSPFTNARHVLLYFGNINSKKISLYPLALKNIQPAASKLVVNIKFISHTVLEVICKESVQIEVIRVFRMLRAKHFINSPENDKLRMLAITPRALTINPSIFKVGYINIGGLSGNKIFNINNLIQRHELDILRVAETRRDNITPLLRGYKVLNSKKSVQVRDRYSNKEGIIVLGRNRIVSEAIDNIIDEGVSIKVNEQIFIFIYRPPKSTEFNITLLQQILDNHAMYGLSEIDILTNTYKDNNKESKPDKIFTNTIVDIKISTIYNIRLLTRLKVVENITNKIEILIKKNANIIRTLNINDYCAALHNIILSGVYRLRIRKQSPREKARHNNPILYERLYKEVKNLTKNLPDTKTRDLKVEHIGLKTSQLEAIINFHGNAIPNNRQNNSNELLNSFVLDGKITSLEETVNWIKLSVDEVEKCMKILKGGKAGGICGIKNEFLKICPRNFIVELTYMFNNIFRDKEIPLLRKKHMIQPIPKGDSEFRSISLIDKTRKLFEKLIFRKFEHSTLNHVLTLDTRLRHSNGEGILVTLDISKVYDSFSREDTILIVALIENNEYKINTLIEYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY12</accession>
    <name>A0A4V2JY12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0303p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000303">
        <property type="protein sequence ID" value="TBU15968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0303p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17240" checksum="72DDE1874CAF3E1D" modified="2019-07-31" version="1" fragment="single">MNIKLHPTLTFTLKNKYKITQTLTSISTVTTTPLITIPTTVYNTPTHIHISPSLPSYPYIHTLSLCITNLTFTFSYNCIILSKPFTSTHKTVFLIEPYTLRNMKRRECNNNKDSKEDSKDNNIDDENINNGTFTNCNCGTNNYSNYSTNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY39</accession>
    <name>A0A4V2JY39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0219p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="364" mass="42681" checksum="01290120AC4A0069" modified="2019-07-31" version="1">MMKEVKRFINNIVLEINKEKPATNKSFEEVQIKLIARIKFRNIFQAINQHAISLLNYHISVHRLEPADFSKLDDSNKIHVRPGCKERLYLPRKELGRDLNSVERAAILNVENNNKTHLSLIKNFLKIKYGLEEELYIARNNELVSVNDSLRWLKKGSLKPRDEAVFCYIQHRNVFWGAEGMSTRCEKMLGYDYTRLYNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRLRKYDLLANDLGLIYKSSVEIIPYVMTWDGIVTKYHKTYVKTLQIPMNIEASIRSILLKKTVQTISFDRRRGLEASLSVILGAAMHKQPTPLLKQVDNEEDEPKTNTNKEFELEEEKEVVEMVEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY67</accession>
    <name>A0A4V2JY67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0162p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="68" mass="8226" checksum="3F70BA726C8C71BA" modified="2019-07-31" version="1">MVNIRPRDETVFCYIQDRIYSGCKKFWHLATPCEKMLENDCIRQYNEVFLNVYAKIRVDTKETTDLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC3</accession>
    <name>A0A4V2JYC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0057p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="26075" checksum="3E46C98F53CD94A6" modified="2019-07-31" version="1">MEEKICNLYYKEELIKRLVVRICSNNVNYVEYLYDTSHFCCRTCTMKILIFFSYSRDSRRKLQPLDAIYAILSSNFKEIHVNELERIPLQFNKNIFFILYDEYQKIFMEYTNILEIKECMIVFERPITINTVNFLKYVSNRISNSQLCLIIEKMNENRNLCEHVLFSRFLNFYIEKGFVSKKCDLVVQIINYCVNNIEIKEILEVYEQIAKISNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG1</accession>
    <name>A0A4V2JYG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0001p0240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0240"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="18435" checksum="31111D1812AF233D" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTIAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVQ0</accession>
    <name>A0A4V6MVQ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0383p0010</name>
        <name evidence="12" type="ORF">CWI38_0060p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000383">
        <property type="protein sequence ID" value="TBU02960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVQ0"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0383p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0030"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="116" mass="13259" checksum="8F28ACA56B78A846" modified="2019-07-31" version="1">MYEFYRQSIIGKALQDTIDEKVSRNQITPLQAKTILERFDACIPTVFNRTVQSTVNFKGGVGSYNFVDGVWRFSTRNFVMTINNELVRTENVKIVACDADTSLDSGRRRRRKADTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0P7</accession>
    <name>A0A4Q9L0P7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0864p0020</name>
        <name evidence="11" type="ORF">CWI38_0160p0030</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="PITJ01000864">
        <property type="protein sequence ID" value="TBU00904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000160">
        <property type="protein sequence ID" value="TBU19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0P7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L0P7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0864p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0160p0030"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU00904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="438" mass="50637" checksum="5ED7F849C8D94C9A" modified="2019-07-31" version="1">MVDAATVFAKNLDEEYIEENTVRIQKHSNVFYNPAQSFNRDISIEVIKNFTKNIESPKIFEAMSATGLRGLRYAKELKNDSKIYMCDIDRNAINSIQENINFNKIDLNKIELIEGDCRKIMISKPDYFDVVDIDPFGSCTPFIESAIISIKNNGLLCLTSTDIAIISNNPLKCYMKYNTVTYKTPAFHELALRTLLSVANRIASKHSITIEPLLSVSVDFYIRIFLRIKKSNHKTRENILKISNYFLCHCFNYLEVPLFNKSDKFRSKKVPNNICNICGSVFNLAGPYWNSNLHDKIFVDEMLKKINENSLNEKRMIGFLRFISQEIDTFLYYSIPAISSYIKTSCVPLSKIISALFNLNYEVSLTHCSLKSIKTNAPLDIIYNIFLKYFNINRDYINLINTLEISFEENKKTNELITKNYYKKLFYSNLGPLSKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L371</accession>
    <name>A0A4Q9L371_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0744p0010</name>
        <name evidence="12" type="ORF">CWI38_0895p0010</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8 9">Cytoplasmic vesicle</location>
            <location evidence="8 9">COPI-coated vesicle membrane</location>
            <topology evidence="8 9">Peripheral membrane protein</topology>
            <orientation evidence="8 9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8 9">Golgi apparatus membrane</location>
            <topology evidence="8 9">Peripheral membrane protein</topology>
            <orientation evidence="8 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000744">
        <property type="protein sequence ID" value="TBU01311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000895">
        <property type="protein sequence ID" value="TBU12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L371"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L371"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0744p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0895p0010"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="196"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU01311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="422" mass="49539" checksum="3EF97ED72541E62D" modified="2019-07-31" version="1">MLIGFFTYNSITEDIFIKTTELMEKEVIDLILSEFTSASKKGTSLITEMFTYYFLEKEDVYYVLVTEYGFQEYNAIKLLKTLIPYDFPSLLFVLDDIINKNSFFILDTESLHNIVEMESQEEKIHEMMMKNKELDAIQKQKELKMRKKMSDIDLQLEKVKNLEIEIRKETILQSKTVEEKEEIKKEKKPVINEDREESILIGIKEKIKIVVDKENNIKNCEVEGDMNLLVRNEEYKNCEIEFSIQKKENLKFNPNLDKDSSKKNKLKGTKGFPVDKNVALMKWKYSEIFLPIVFTFWPSEVGIDKYQISMEIVTEVENCEGLKLFFPLKNIKNVILESDKCVLGKEFIEWDIGSCKERGSSENIEFTCSTDDVNNVFPIEVFFRCKSIFSGLKILNVKEKENLDCFSVDEMFEVDKFTIVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L444</accession>
    <name>A0A4Q9L444_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0747p0020</name>
        <name evidence="3" type="ORF">CWI38_1062p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000747">
        <property type="protein sequence ID" value="TBU01300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001062">
        <property type="protein sequence ID" value="TBU11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L444"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L444"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0747p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1062p0020"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="291" mass="33323" checksum="EF7CBB9D51D3D7DC" modified="2019-07-31" version="1">MWVYLVGIPILICIGVYVGRGMSRRSINFKNKKVLIIGGTSGLGLALAIEIQKRKGDVTVAARRFDLLKSIKEKHGFSVFVADAVRYETLECLGDDYDFVFNCAGICYPGYFEDLDVDVFKKSMEINYFGTVNTLMHFYNNNKRPFGFVMVSSTLSFYSFPGYSSYSPCKAAINSLFDSLEMEMARSGVFLYVYYVSTIKSRGYDEENKNKPEFTKDIEGRECSKSCSPEERAKHLLNSMYYNNRIVSDVNTRLLKVAGRCDSVLDFLFLPLALVLVPFWKLYVKIKFFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4J4</accession>
    <name>A0A4Q9L4J4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="4">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0405p0030</name>
        <name evidence="6" type="ORF">CWI37_0491p0020</name>
        <name evidence="8" type="ORF">CWI38_0015p0040</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="4"/>
    <dbReference type="EMBL" id="PITJ01000491">
        <property type="protein sequence ID" value="TBU02394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000405">
        <property type="protein sequence ID" value="TBU02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4J4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4J4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0405p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0491p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0040"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000122">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU02394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="234" mass="27528" checksum="80F0C3CC434C3B35" modified="2019-07-31" version="1">MYEIILPTYNEEENIQSVLYMIHETFKEINMDYKILMVDDNSKDNTFEKAIKMKQMVNVEILQREGKLGLGSAYKHALKYTKAKFIFIMDADMSHNPFYMKDMIEKQKINDCDIVIGTRYLKNERSGVSGWSFYRKLISRGANNLARILLNLKVSDVTGSYRLYKRNILKSLIDKVESDGFSYQMEVLYWAQRNKFSIEECPIVFVDRISGSSKMGLNEIIKFFFKIVILFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8D6</accession>
    <name>A0A4Q9L8D6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0377p0020</name>
        <name evidence="6" type="ORF">CWI38_0228p0030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000377">
        <property type="protein sequence ID" value="TBU02990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000228">
        <property type="protein sequence ID" value="TBU18861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8D6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8D6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0377p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0228p0030"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU02990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="233" mass="25988" checksum="E42B35B82A347E27" modified="2019-07-31" version="1">MSNSKQDVNSYSPEGRIYQIEYAMQAMNLGTTTIGLVTSDGVVLCSEKKVISKLQISETIRKHYKIYDHIALAFSGISGDAKTIVSKSMECCLNHTQIYNENIPVEGLLKHLCQLALKFSEKDMYKKIFSRPFGASILVAGFDTEPKLYSIDPSGSYYRYKAKAIGSAYEAVETELKTVYNTIESSDDAIKKGLGILKGVMKDPLDKENVEVCVVKDKSINFLSSDEIQNYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFM2</accession>
    <name>A0A4Q9LFM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2512p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002512">
        <property type="protein sequence ID" value="TBU06754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2512p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12225" checksum="7C904E793A5E39BA" modified="2019-07-31" version="1" fragment="single">SIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHR1</accession>
    <name>A0A4Q9LHR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2466p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002466">
        <property type="protein sequence ID" value="TBU07025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2466p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="406" mass="48452" checksum="854B7FAE7CE31A1F" modified="2019-07-31" version="1" fragment="single">SDDDDKKHEYFLSKISEILEKKIIFELDSRMNCLEKFSTDKTFKNLNLKIIFFWLQTLSKELFKIDNDESLMSFKEIIVAQAAEEKVYGFIVHLKANIALFVRFNFEYLSDCETNLSQINIIVGEYLIELFLNDFQDKVFHFFPQFQTALNFIFNSENSYNHLNLYSALPTFLLIIIAEDTYRKLQIDSRDTNDLLYSNFYLERLLILNYLIREIFCSLNNISDKVKPETFKMIAEFMEHINFFNENKFKLSPNPISEEYKLFTYYNFYYSILLFLYIGDSLVKNNNFETSLFDIIGYLNLVFNEYKNKTTLNFPLILNDIEEKSKNLIKLKAFEYISSQTAKSELINVKLKILTESLDKHDITSVFDKIEQYNRYVWMDDVKLSFENIGEKNRKQFRKAIKQIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI43</accession>
    <name>A0A4Q9LI43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2346p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002346">
        <property type="protein sequence ID" value="TBU07823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2346p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10775" checksum="9103182804F74116" modified="2019-07-31" version="1">MILFIVLLIQEHAYSPEGFKNDTKTIYFQCNSYQSQEIRQNRSFPQSLKSKIKKLRENENCLCDCKPKTRSSHFNTVNRKKQNAQPDSKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ46</accession>
    <name>A0A4Q9LJ46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2420p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002420">
        <property type="protein sequence ID" value="TBU07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2420p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11074" checksum="A485C81420E8414F" modified="2019-07-31" version="1">MLEGVRGLEGEWGVLVVGICGRVLVYRICGRVLVVGICGRVWRVLLIRVVDKSIKRVLGDWRVERWRRLEGFGDSRDVLEGVSDSRDVLEGVSVCTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKB7</accession>
    <name>A0A4Q9LKB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2354p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002354">
        <property type="protein sequence ID" value="TBU07771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2354p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="22315" checksum="92817B3D636B718E" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKY3</accession>
    <name>A0A4Q9LKY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2203p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002203">
        <property type="protein sequence ID" value="TBU08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2203p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="42317" checksum="6705DE910D20BED6" modified="2019-07-31" version="1" fragment="single">MYFLFISIQKITRSETNLNNSINMTNSNWISLYWVKFLLFICLGFWKFVVCTSESKDGKITFALIDLNWKEDIDKVEIKKIKYWLSRSNEEETFTFCPGNHVIKCRGLSITDFACSLGRSSQNHQPLHSFEVNYKENWKIKFRSLNRFVYMQLEEYPFLFEYSLNVSYQEFQIFVKHLTFDSGTPRQNLTYENFYRFLKILDVLDPISSEYLNQFYSHLYRECLLEKVSVRIFEDSAHYRENLFDEKHRIRPFMYFFCTLINSIDACFIPKSSTLSLFEKKKQHIDECFRDSIDIANLILKISSSSLELLLRSLKTNEWAAFNWLLAVTKVSGFYIDNTELTFNELKVSSVCSLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLM9</accession>
    <name>A0A4Q9LLM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_2099p0010</name>
        <name evidence="9" type="ORF">CWI38_2197p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002099">
        <property type="protein sequence ID" value="TBT97740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002197">
        <property type="protein sequence ID" value="TBU08997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLM9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2099p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2197p0020"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT97740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU08997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="166" mass="18700" checksum="A75446A1FA54CA16" modified="2019-07-31" version="1">MKEISIFKLTINMCVGESGEKLNRGAKVLEQLTGQKPKFSKAKVTIRSFGIRRNEKIACYVTVSGEKARNILQNALKVKEFELPARCFSSSGTFGFGIQEHIDLGMKYDPSIGIFGMDFCVMLGRPGFRVSRRKRCKSVVGKKHRIGKDEAAKWFVENYDGIILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM95</accession>
    <name>A0A4Q9LM95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2146p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002146">
        <property type="protein sequence ID" value="TBU09468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM95"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LM95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2146p0010"/>
    <dbReference type="OrthoDB" id="2196355at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="493" mass="56656" checksum="83970363549C941C" modified="2019-07-31" version="1">MDEYTNLITDTSIPEKIKKTVLIDIALHHQNNHQEIINTLLNTPTLLSLKVLLYLINHKTEYKDILNKKKEILYEIESIYNKEESNRDSIRNGDRDSSRTSIRDGNRDSSRDSIRDSIRDSSMNNINTTDTKDNINITYTKDNINITDNTIPNTTDTNIPITTDGIVRDTLISKILKILSNTHVLLPVPIPLYFYGLVTRNEYQYFYRKYNYSKYCSSGSSGGGNYSIRDSNIRDNIRDNTRDTTRDTTRDNKDKLNINYKGNIRDNKDNIRDNIRDTKDNIRDTKDNNKDNTRDTKKIKSNLYSDISILFKPLQCKICGLRFGSEEEDKNIFGLHLEEHSRKNRAMSDRECVSREYYCGVEGWCTSISKLHLSSLMGSVIGNMGGSMGGSISSNITSNMDSNYTGNYIGNISKVRCDGRAPLCCVCGCRIEVVWDDEEDEWVLKDGVGVVKEGEYNYCHRDITIAIGSVIKEFSIKYYIVIGRYMILLFYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LML6</accession>
    <name>A0A4Q9LML6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2258p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002258">
        <property type="protein sequence ID" value="TBU08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LML6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2258p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="9381" checksum="2FD347A50D3F9E8A" modified="2019-07-31" version="1" fragment="single">MILLLFIFLIKSESEHSSYSSTFSDEIFKRLFESDVNGSEYIKGKVVKGTEGNVGYVNTENEPNEEFNDREAPLLVKNDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPH0</accession>
    <name>A0A4Q9LPH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1852p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001852">
        <property type="protein sequence ID" value="TBU10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1852p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20815" checksum="33587D54BA5E7F3D" modified="2019-07-31" version="1">MSSHSADTENCQTTIIDAIRNDDIFWMEFNAILNHLFHTHFIYIQALLYFRRNTNGLISSNINLNRITTLFIFIARCKLFCFIEIDCFGLKIKRSLKFNVNSEKEVPIIRENILDIFVKRETIYNEMLLCLQKKSLEFHRFELFEFLNGIISRDLGPKEDSAFIIKFIEKLLVYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPX3</accession>
    <name>A0A4Q9LPX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1786p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001786">
        <property type="protein sequence ID" value="TBU10404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1786p0010"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15553" checksum="D5D345B1D6074FA4" modified="2019-07-31" version="1" fragment="single">EPVIDKPITEGVNYKDYREDTGNREPVIDNGNKEGVNYKDFRNRRFNEEKEGENMEKSNSEECNEAEDKDECIKKEDGLEIGSALHIGEGNKEVEGDGVQYMLLSDIMRRRGIKESGDEDEDSENAQSLDEDEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPX8</accession>
    <name>A0A4Q9LPX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GDA1/CD39-like nucleoside phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1901p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001901">
        <property type="protein sequence ID" value="TBU10257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1901p0020"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd24003">
        <property type="entry name" value="ASKHA_NBD_GDA1_CD39_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020518711" evidence="5">
        <location>
            <begin position="24"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="47479" checksum="A42C98CE67854A5C" modified="2019-07-31" version="1">MIHNYSKMNFIMVLLYFIKILCSVFPEIQPILEDKGYKGKSEYVAVIDAGSTGTRLNIYEFLEPGYFLNSYFVAKSEPGLSTLRDRDKIEKTLKTILDEGSEFLDSKNISIKDIPISFQATAGLRMLSEDLTADILENIKLFFHAKQLNVKDYEIAVIDGMREGIYALESLIYLRTFEKNVIYNLFCKNLERDNKLRHPDIEKCSEIILNKNEKDTRKTTYGIIDMGGGSVQVALQLKNKDDNLPERDIIPTHSFFMYVHSFLGYGMKEVMEKIYNHSDFSYCLQKDTKSLETCQDIFKEIFIDSNNTESLKKIKKPDINSVDELYLVSYFYDILSQLNIDKRTTLSQIKRNFLAKCSFLDTEFCRQGFYLINFLDEYKLEDDKEIIVTNQIDGFYLNWSIGKALSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ01</accession>
    <name>A0A4Q9LQ01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2003p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002003">
        <property type="protein sequence ID" value="TBU10126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2003p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7007" checksum="6462D282F2C33654" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHSPAISLPSSSYTTITPPPPSQTCSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ05</accession>
    <name>A0A4Q9LQ05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1692p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001692">
        <property type="protein sequence ID" value="TBU10539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1692p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="12025" checksum="83A763D7D7326DF3" modified="2019-07-31" version="1">MEGSKDIEIYYGMYRDRDICIERDRDRDILYECIEIEIYYMDGCIEIEICIIWDRDIIWMYRYRDMYRYMYYRDKYGNIRNTEIIRRDYKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ50</accession>
    <name>A0A4Q9LQ50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1839p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001839">
        <property type="protein sequence ID" value="TBU10337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ50"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1839p0010"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="213"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="46350" checksum="68DB26013AA8E91E" modified="2019-07-31" version="1">MGVNLKDILLPVIKGSYFNTSKHIEKALEQSKNVYRSYFAKSNSKAKSVFRRIIQEKQPSQIIPFMSGMSLTLGVTLFFLSCKSLPLLIPLNILILASLFFGLNMVIFDLKFINYKLIFQHDISSSINTGEYLLLIGILCLVNNTLYYIQPFFNIPIPVIPIILIFIIITPVNFLYKKTRYFFLMAIFKVITSPFFSVKFCHFYIADCLLSYSMTLSLIFNTSYIPLIFLTFRILQCIRRYLDTNNTLHLYNLGKYLTGVIFFIISKLYLRYSYLYLVFYFIGYFNTLYSLYWDFKVDWGLTRKKRLFNISVYLFIALYDVIGRLSWVICRFYENKYFYILFEVVRRFLWTILRVEYEHLNNCDQLKALRGVDLPVEDLFYQEDRGDVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG0</accession>
    <name>A0A4Q9LQG0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1659p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001659">
        <property type="protein sequence ID" value="TBU10594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1659p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="25705" checksum="00D172513CE48DCD" modified="2019-07-31" version="1" fragment="single">TRRHNELVRYLHLLLLNRYKFKSSKQIRSHSVQEILDNEYAEIRVDTRIKTDITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRRYCAKYHKFHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRKGVESAPNAEESCERASMCVIMRAEMHEEPTPPLKGDKREENEAKNFKLKNKAPFILQGGTTLEEPTNNINEESDLEEETIVAKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQI7</accession>
    <name>A0A4Q9LQI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1853p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001853">
        <property type="protein sequence ID" value="TBU10316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1853p0010"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="18216" checksum="1B887B5478600A79" modified="2019-07-31" version="1" fragment="single">TLITSTFIFQNKTFVIINCDFKLNKLDFDKKNLFYLFLNDLQYKYKNKNLLFLGNIDTPIILSRKTIQELIQDNKFKKILSRNYLSIILKNFDDLKEHEITFQPKETLKNGVPCYSYFNRILFLGNFISREYNYIFTNESGYDCIFGFFSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR64</accession>
    <name>A0A4Q9LR64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1571p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001571">
        <property type="protein sequence ID" value="TBU10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR64"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1571p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="503" mass="59590" checksum="FD983E34259F115A" modified="2019-07-31" version="1">MKFDKAVTLLIFFSFVYSIDFDEYFTRFADNKLLFCISFLYVENFWINLENFIIFNKNLSETEKKIFLKNSFGVEILYDIKKSEKRVDHFLLNRSHEKYFFSHKFKAMAFLETVNSVFEKNILLFKKCMTRNKKSIFMEDYLSVFLAESKDLLKILSFLQTNKNSESLPFSNEDSQNKIKCHLMNSLKYIKEFKLFKCLYDSFTKENFNFFKELSKNEILEISTANKYIGDLTETSEEGKTSIELYETFERSFPATFKIHDKLLKKVNNFTKSINHLISDYSNPEIEIFSNILFFNNIDCEPNELLLNDNVIIFDLDDTLYEKNTGLVENIHTNVDSFSDLLGINKSLFKNLYEKSKKSNTRYLIEIFKIRKISFENIHEIFYGNIPYNDKLDKNSSVIEIFKGIKSRKICFTNGSHIHAIKCLNAIGLLEYFDAIFSSYIGEQDVINKPNADSYNLITNFLFYRKFTIYFYDDKEKNLELPIKLGWKCFLINEDILERMDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR67</accession>
    <name>A0A4Q9LR67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1428p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001428">
        <property type="protein sequence ID" value="TBU11019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1428p0030"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="7919" checksum="566A747DEA12F95D" modified="2019-07-31" version="1">MRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA7</accession>
    <name>A0A4Q9LRA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1378p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001378">
        <property type="protein sequence ID" value="TBU11113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1378p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11144" checksum="4742933BCC49B312" modified="2019-07-31" version="1" fragment="single">VETISFDRRRGLESGLNAEESWERASMGVIMRSEGHEEPTPPLKEDKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEETIVFKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG5</accession>
    <name>A0A4Q9LRG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1616p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001616">
        <property type="protein sequence ID" value="TBU10676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1616p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="423" mass="49493" checksum="795FBF4F7B6411F7" modified="2019-07-31" version="1" fragment="single">MHIFIQFLIVYSTNEIFKTAVCNDNIQEEVTISLDNSNVQLKEKELKSKVDGSDTKMLDNILKNEITGQNDSSEKTKSTESNSKIHSNREPQRTRNHYQRKSTSHGYPSKIREKRFGKGVRRSNPIMKNGGKKLKSVVHLPNMKIYQPTNNFIQFSSYSRLDIIEPLVFINLIQKNELKDLIRTIERLIRNNKKIQKHCRRAETWEYIDYLANLIEASDGPLEKLNSNILTKIEVSEVCLQTYDQPKNNLMAIIKWLTTIFNTTKLLKDTSLVKEIFNKFRRGNTTKNELQRLNYLLIKIDNLLKSKELIHNPQIHFDKQQCVRKLKEIFEKEFQKKIYCVFPDLEMVLNSFFGNVEYSIKLSLKSIFPTLCLIILTNFLCEILTEDEFSGKTHFLASQASFPYILLIFLIIRDLFFSLDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH6</accession>
    <name>A0A4Q9LRH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1369p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001369">
        <property type="protein sequence ID" value="TBU11128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1369p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="513" mass="60305" checksum="CEDFCA5B8B2FE1AC" modified="2019-07-31" version="1">MYTAADKNEVKWPDYDEIRTEMFNNPFVYYVSMICLNTFRKQNVVCKIIHPCFKNMLERILGKHLILNYIEYDRSFAENNEIEIKLLEFDLNAYFEKESIIFNLENSQTPTEAALSHMMQPEIEETVTFGSKKLTITAAQSLNASDFPEKDVNMIEVNEENATLNSYSKTYQTFAERNKVTNQTDNVILSSEVMRMNTEEINHSRNNIIYKSDSKDILKLDLELFFEKIFQANLEIQAKNTQFFEYKKSDLYKKHKEMCQNGKFDSNHNIFSFFYKILYLNYETQWKTLLSSIPNESYIGYGNILAYLDEYILSSAFQMNISNSSYFISIEDSDFPKMYLDEIVLVFDIDDTIFPTSFFRKKNPNFGSTRFYENSDLLQEELLKENPGRDNIVTDHLKYKFELKTYLQKLPFKKICFTNAAKIHAEWTLKTLDLLDCLICVVHTGEAYEMMFLKPNMHAFFAIEQLLEAKRSNIYFYDDGVQNVQAAKSRGWNSFLIQDSLIDVLETSLSDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ4</accession>
    <name>A0A4Q9LRJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABCG-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1896p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001896">
        <property type="protein sequence ID" value="TBU10261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1896p0010"/>
    <dbReference type="OrthoDB" id="2196280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="588" mass="66564" checksum="9AB15788FB0489ED" modified="2019-07-31" version="1">MLETEDVKISWMNLNLKIKNKGLNTNQRSIIYNEFGSVGPKSMVALMGSSGAGKTSLMNSLAGRIEKHIAISGKIYVNSEERDPNTWPHIMAYVEQEFYFYENQTVEETVLFSSLMRLGGSETTDFIKNRTDEIINMLGLCQVKHTYINKVSGGEKKRVSIASELVGNPQIIFLDEPLSGLDSFSALRTLKILRELVNHGKTVLITIHQPSYQMLSIFDEMILMADGNIIFSGVVDDCIDFYSQCGFEIPEKTNPADFFLNIASVDTTTPETIEESNKRIEKLKEKWAQSRQEIQILNKSIKLIDGKGSSRFTFINLLKRNFLDLLRDKKYLKIQIIQKIIFLLLLGLTYINLGYSQDAIQSRVGVIFFILINSVFGTAGPLLNIFPKEKRIIQRERRSGMYDGVTAYLAKFIALIPFIIILTITYISAVYWMIGLYPSAGRFFIYLLIQASLLLFSIALTLTIGTYSPSENFSQVLGTTIIIIFIIFGGSFSNPNTIPSWLSWIIWISPIQYGFKASMQNQFDGLEFICNDNDPRCIESGNDVIILYGMESPSIWPCILTLWGLTVFWIFIGAIGLHFLTKISLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK4</accession>
    <name>A0A4Q9LSK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1162p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001162">
        <property type="protein sequence ID" value="TBU11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1162p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020779256" evidence="1">
        <location>
            <begin position="21"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="644" mass="76800" checksum="90E05EC217548945" modified="2019-07-31" version="1">MKFFFTNLYFLVLFSFQIWCNNDSAMFEEISDVLPNYQFIEDNIMKAITKNIDKKERSFNDFNKKLFFVIKNIENQSTKIISEMAEEAFKNTEELRVSVLKYNTLKLLHPGSLINSHYNYLKYSNYLEKIKKYDDHITAYENIIAEINDECKFYVANDKMGIEFEVFGEICLNKENLLNVTEKIENTINNRSKDENNEKFLITIADCKLNSYDIAYIDMIIKQQNILHIDSKNMLVYVRKEVLIENDDKGVPKLDILEFFKRKMIIYKVFIDISYNFKNFQTSDTKIEKYDKDKRPLSIFFDKLEMNLNKNPRKKTVYSNLSIKDLEIQSLKFNSGSEFVYRCLFYKIHFNLVDSSHRLYDTIRNGSEEFKIYEFYFIHTTNSQEFMFYFIFDKDKNLKYVADVNTIYGTPNHDEEFPKFNLEAFFANLRKFIFSQSVNLNDRNILEVEKIGIEEGLVVNDELVRENVVQIKSWLPKLDEKFLEKKKNVQNEIEEYFRTQNCRVKFFDFETKSVKKENLVFIINPKSRIATRDIINFKFPLRLSTFNSSDSCKIAKEILNKTLKNGYSHVRAPKTISQIFQNPSNELLLIIKTMYNNYSVPVEHYLFISCDVATKEMKYSVACSDKYYDEHYYKLVDIIERNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV9</accession>
    <name>A0A4Q9LSV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1530p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001530">
        <property type="protein sequence ID" value="TBU10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1530p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="48940" checksum="73125B4E5B0A3F9C" modified="2019-07-31" version="1" fragment="single">IVTQIRKLPRELIDSKITGEYAEFHVPTNVSDAARIIQAAQVCYSEKSIESKLCRLVLYKDLFNLDLTRINDFSRAVQEEIPKREFSLTCCFSVEISEFWSKCETKKINTVTFLEGICVYKHLGIIEDSRGVPTIKSFEATYCTRFNARNLFQAIKKNLISLLNYHIDFDYVVRAVLVKNKIHIRLRCKERLSFPRKELGRCLHRVENNNKTYPSLIKNFLKIKYGLEEEIRNVFWGAEGMCQHSNQSRKTIDHLATRCEKMFSHDYKDDIRSGTISRNSDNEYAEIRVDTRIKTDVKIRCNGPDIFILDKRQNRITLIDVGITTQDSIRIMIPYVIIRDGVVTKYHKTYVMRLKQEDCIINCYFRAEMHKQPTPPLKIVDNEEDDLKSENSKHILPLILHSMTTAKEPKTNTNEVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT60</accession>
    <name>A0A4Q9LT60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1094p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001094">
        <property type="protein sequence ID" value="TBU11664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1094p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="24366" checksum="BD0E2BABF690DD3F" modified="2019-07-31" version="1">MDNASCSSQILFTSIPNEPIKTMLNDNFESQDITGNIINSQNEEIDGEIQFMNVLLFDDLNDYNLYQELDCSESVSDLSVTEMISENVDMKKAYSNSSLRNHETENSVCSNLCNIDFVHNASDFCVSGFLTIKPRQNTIKKVKIFSQCLNEDFVDRFVNILDNSVPEQGDQAGGSEPPINSSHRKRNFTLSYTDYANKSAIERTSPLDCISKKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH5</accession>
    <name>A0A4Q9LTH5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1412p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001412">
        <property type="protein sequence ID" value="TBU11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1412p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="85929" checksum="4D3C7F86D7970887" modified="2019-07-31" version="1">MESDILFFRENQEEILLNEEIDNDFGFEIFYDSYIKHVNQDNCIFRCTKENFVNFEELNNISFSNSTKNKFKIGIVGCSYELSHILKITNDITEMPLNMSNYQFKCILKTLKSLKAVENKNMLKLLQVLIFNYFVHNLYNGSERKPLLLQETFQDDFFENLEFSTTKNFIFAFLNIFMIKYSFENGNIILVDKCKEYYDNTLLNKNIPYKNILINNFKVVYILENIFKNRCILCTFQILLNYLSMKSLIVDNYTNLEIYEQNYNFAIFSINVFKSISISNFTNQSAVRFLDRLSAVIRNDLEFLCLINLQITRNAIRLFLNQKKLRGLVLRGIRKIEDVDFIQDYTDCGKKLEYIDFKNVILKDTWWNYFLQVSNVSKLILCFCTLLQQNFFLKEFVKIVSDKDILYFEVNFCYSEISIDFYHSLFYFKSLRTLKIRRYKNTEITERLLYKAIENMSKLVCLKIKQEYICTALYISNLLTSQIRSVHLERFFSCAETPMFYFLNQFKSITKLSLVNINIAPSSLIEIFQLKNLRKLLFMFCTIKKIKIKPESLNSMSNYISSLDLCNTNLGILKNVDILWQFDYLENLNLSACKLPPGYLANLSLKCNLRLKKLSYESSTLDSTDLLRIANLEILEQLNLSKCKFLKTSFCRLRNKCKFISTLKKLDLWFVKMNAEDLSYLRNFIKLEKLSLTFFCLNPRTIQNSLPSRPILHISTRVLVKNLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI7</accession>
    <name>A0A4Q9LTI7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1502p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="PITK01001502">
        <property type="protein sequence ID" value="TBU10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1502p0020"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="55752" checksum="FD10B0E41C671E0A" modified="2019-07-31" version="1">MKIAYMFSKQVGLHHYGQGHPMKPHRITLTHSLVHSYNLDKYLDVIIPTQLTLGSYHNPEYLRDIKRSDEICNVEYDSNKGIVVGLEGDNDRVYDYKGVNNSTNEQQGVNNSTNEQQGVNDSINEQQGVNDSTNNYHPFNNSTNTYHPFSNSTDTNTTNNTPCYGDDCPLFPNLYDFCTHYTSASLLCARLLNSNTYKTTINWSGGFHHARKNEPSGFCYVNDIVIAIQELLKCYERVLYVDIDIHHGDGVEEAFMHCDRVLTFSLHKYGDNYFPGTGGLYSPGSINRGCSRVESKGCYTTDLINNTPLTTSTNTNTPLFTSGVNNTSYITNHTNNTPFSYIVNVPLRTGIDDPSYMYIYEPILKSIIRKYNPSCIVMQCGADSIMGDRLGCFNLSVKGHGECIKMIYNLNLPTIFLGGGGYKMKNVSKCWTYETGLLLGVDMCNDIPKNDRYYEYYGSDYTLHGGLVKKYDNMNSKGYLDSVMGYILKEVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK2</accession>
    <name>A0A4Q9LTK2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1396p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="PITK01001396">
        <property type="protein sequence ID" value="TBU11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1396p0010"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="522" mass="59729" checksum="A63D534970C4BEE4" modified="2019-07-31" version="1">MKPSKSIQELIEEKNEERHLKLTRKIQIGDEFIYIDYTRTHVDEGSLKPIYDNMKGIEDKIDDMFTGKKINFTEDRKVLHTALRDKDLIRKLSGEFPDLELTKECTEIYKEFMSMKKFSDKFNNGELLGITGEKIDTVVNIGIGGSDLGPKMACHALNFYKKGNTKVYFISNIDGTDTKLVFDNIDPKKTLFIVVSKTFTTLETISNGNLALNMMKDALKLPEKDIAQHHFVAVSSNLDEVKKFGIKNVFGMWDYVGGRYSVWSTVGLILCLYIGFDNFLEFLKGASIMDEHFKSAKKNENIPILHAVIEIFYNHRLHYNNKCIVPYDQYLSTLPSYLQQAEMESNGKSITKNNEKVERTCFIIWGGTGTDAQHSFFQLSHQGTRETLYEFLMPLSPLNDYKCGNVSHHQMLISNCLAQSRALAIGKKSKTNLHRNFTGNRPSITMCYSKLTPKTLGALISLYEHKIFIQGIYWNINSFDQFGVELGKTMAKEILKDIEEKKHDDNDSATKEILDLVKILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK6</accession>
    <name>A0A4Q9LTK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1106p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001106">
        <property type="protein sequence ID" value="TBU11637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1106p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="787" mass="93763" checksum="BEE68ECA91D19957" modified="2019-07-31" version="1">MKSECNNSGFYRKTFIFNVILYILNSVLEKLNTKIFCTEVNFYFIHEKYVEEIISTKRLHTMRIPICDQLREYETACLLENRVIMCNSTFNKVEYFSYKIFSIEYPKDLILESNLIESYIKSGETTIHIFLGNFSILSLMKFFKLISSLDGFISQIQLNEFIQYTKFLSIFKMNRTENRKYFLKNFVLHVIMDPGFLEKNSYFLTTVYDKYEDLDKELINEIFNIFLYFNLVKQKKESCFFSPKIGPMYSPEIKSNFLTYEYLTEKYNKFTILQITDDDLKSIFNVMDHDTFIARFHFLLRMMNIDVLFINISEISEKILISYFKIKPNKLTKIYFVENGSDQYILDILISTNYFDGIDIVKIYSEFEIEKIDYIVKMCVRCKKIKVSNVIYFEKTVKTLLKFAEENKNISVKYQIQRFIITFGNLILLQDIPENMIVVVGQVNFEILAYIRLEFICIYDFIKNIEITFRKDKAGQELILKCKNVKSLFLISEDMKCNFKFKAKWIQYLENSKNLEILVFKNIILPKEMLNFILNSNSLVYVGFFETKFPQSFTIHPKFNHNNTHIRGFGFSNTKIVLKNSFLRYIARFSNLKFLKLNITRIKETLLKNYKKESNASNFQTPKVLLKYLEIKASLNIPKERLSILSILSRYFEMKFISSLIIQVYDILQEEYRIINDLNNLENLYIHLNTKINIPILNIFENISHISKIVNITLDIFKCNDLDPLVLRKFKNLKFLNLYCYEIDTTSIQILDSQTVIGDLIIRITTYDNTYESFTERNMLYELRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV9</accession>
    <name>A0A4Q9LTV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0912p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000912">
        <property type="protein sequence ID" value="TBU12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0912p0010"/>
    <dbReference type="OrthoDB" id="2189560at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="25138" checksum="B991632422940E12" modified="2019-07-31" version="1">MKILISIKMTLMQTKVKVLLTGNVFNRISINIELRQGDTFFWNTDCTIFNRITQYIANTGHLAIEERNPEVMESTLKILDAESGKYFLIINETKTKYMLIAKSFDLHLRIREDERRMEENHPFFMYDKTSQNEILEIFELQGEVENIELINCHFNRDKIQLVFDNFTLNGYLDSSKCFTVVKRTKSETGVEHKSVGVCKNVYVFSQPPKFKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU11</accession>
    <name>A0A4Q9LU11_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly(U)-binding-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0937p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000937">
        <property type="protein sequence ID" value="TBU12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU11"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0937p0020"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="162"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="43542" checksum="5DA1B53E2D3BA2D9" modified="2019-07-31" version="1">MGKIILNTEELPENYKRIVSNKKKNIEDLHNLYCQIVDYNTWVLPSTGLLPVLNEDLHAKNFSMHLLNKIYVGNLPYHTTKSDIHKMFEIFGPISSISLSIEGKSKLYSKKFGFVEFENPNAAVLAIKEMNTYEVDGKALKVGRPANFPSFIPDDIKNPDKRIIYVSNIHEFIDQNQLLSIFECVGKVEQLNLMLNKNRSCHMGIAFIKYQNIDSADLSVSLYNNLYVGGKILKVCKTVIKQKMPSKEIFQDTITKLPNEVIKIIADLNSKLNDKTENECLVLKNMIMVDDLDEDFINEIKLELKKYGEILELKIVVFQPTLLQYIILKEGDKKDVEVYCLFRNSESVNHCYRIMDGRYFGGRRIYAESIPKSEFNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU27</accession>
    <name>A0A4Q9LU27_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1296p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001296">
        <property type="protein sequence ID" value="TBU11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU27"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1296p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="86447" checksum="BBC1606E5FF934B1" modified="2019-07-31" version="1">MEYLYFAAIVLNQIYANQFVDFYFKWEGVNLNKESTSIKDLELTNDEKQQLKDLRPYREIAKKIKNKENTPLFTTNSNNNTIKIIYPGNIKFKIGIIENMKCQKKPRLYIGHLISKEVFEFLIEIVCDLTDIDFQLPAFLYIQLINGIISLIPETNLYFRKLLSRLNYWAFTGNHLNEIIMKKNNLNFDNCLIKRFFYMTALVSYLNYINISVCFFGSNIVLDYAYVTYCDIYPKKEELVKELSLQFTGRCLNSFFASINEKNNKILYEWILCGIENIVSITFFECNFSNLINVNESINCLLYKENMSLQLKNCISSKNYIRNINQCRSKNLAKMKLDDLYLTSEDLVSLIEFENIDDIEFDNCIFDEDEIPGKFTFVFLSIKIKNMKIGNSMISFLKRSFSDFLYFENINSMMSFSILNLFSDPERSRFVRVIELVDLNLKENFFDLTYNFPNLIFISIKSVKYLTFKINNKEKLESIGLKRISIKDCCLPNVARNIWYIPSLDFLVLYRIKNIASFFNNLKDKKFIKILKTLKCKSNILNHSDIEKISVFTNLENLKLQSCNLDSSHLIYIKKLTSHAEFRRIILTNNKIRNVPDECKGIFENTELVILARCDFSAGSIHLLFNVSESCKILTLDFSYNSLNRNDLLFISGFRKLVVLKINGIKFEGDAELDNLTSKGLTNNLKHLEIKQLNICTKDIEALSKFIALDEIRLSEAAYRVLKESNIKIPCKYIKTENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU36</accession>
    <name>A0A4Q9LU36_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED18</name>
        <name evidence="2" type="ORF">CWI38_1291p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001291">
        <property type="protein sequence ID" value="TBU11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1291p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12460" checksum="A0FFA20168977EB3" modified="2019-07-31" version="1" fragment="single">MILSYKNFIPQKIARIDTYLKSKDHKIILQSCSNSNFLIYKNEPDPTKTLKTIINKINRSEVLNCEDTISFLNLANFKQEKKLFLEGIEYVKDNIHIEVTVHSITNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU57</accession>
    <name>A0A4Q9LU57_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1386p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001386">
        <property type="protein sequence ID" value="TBU11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU57"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1386p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="31459" checksum="0FEB8F9FFB7B7A83" modified="2019-07-31" version="1" fragment="single">MKEISFLKQLSHPNIISGTLFSNGYINYLEMRFVEFDLTEYILKQVLDALYYLKNKQIIHNDLKHNNILIDEYLNIKICDFGISCYKKELAFPFKTLPPTDLEKYIVYSPELKKSKEYDEQSDMYSFVDSLLMSAYFDFLYENMFCFGELKDFEIKTETKFISKKDKILTIIGENENKIDIFCCCHILTSLRYTSKSKKLNLGENDYSNSTHTFNQITTKRFLYSVDKYALEPIQFMTRADRLEYLVFFSSYKKYQEKYQFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU98</accession>
    <name>A0A4Q9LU98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1263p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001263">
        <property type="protein sequence ID" value="TBU11331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1263p0040"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="310" mass="35399" checksum="8D89C34423353C7A" modified="2019-07-31" version="1" fragment="single">MNYKRKKVDSENIKNEKIKAVNNLENSAGEILMCDVEVAMLSERFPPPPTFHDTTHQPPSRGCQTSPVCLVDTIPSSSGTDATAFGTANGMTNLTTDAILEGNRLMQEWPRSAILAVQKRFERMPRNGWPVTLRYYTEKFSCTLDIDAEIRQEENGERRRIATCLTEPYILTDTTEYINLRDKFLSKIKEISEKEIGKVVVRTRKLPSELVDRKVLVLINRIIGDYSDSCVPMTITVVARIIQAAQVCYDEATRKEKLRYVWKESIENQSDKSRKQKRVSTSETINLKKTNDLSEPLVEKNESLNVYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC8</accession>
    <name>A0A4Q9LUC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0970p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000970">
        <property type="protein sequence ID" value="TBU11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0970p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="16807" checksum="0F02C691950FB5DE" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN7</accession>
    <name>A0A4Q9LUN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0782p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000782">
        <property type="protein sequence ID" value="TBU12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0782p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020936473" evidence="1">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="549" mass="66143" checksum="C4E5B865C30F08A1" modified="2019-07-31" version="1">MRGTLFVVGLISLMIERTTCISYINVGCNTMHILCSVVCSGRSQKKNMLGAKNDNFKDSINDTKIRDCKEKNPYHSPMQRQGKRFCLITTNSMEDSFDFHYIMEPGFRFMKESIFDTIDFLTTEEYIKDINERNKEYLKNKKLDNKFVGKIISNFGSVVKKKMIDFLKNRFSQPINSDKINADFFDDAYLVFKEEIKRFIVEFKRDNEIDLKEAACRDNAKEKIISNILEVMKSKFFLYDCVEKLVYKFYQSLYLKFQKEIYFRFFGKTKEECIEIEKEKNKIYKRLQIMKEKLQFDTELDNIFVPFSIREKHLNFTSFFSLLCEFCAEVRINFKKAKKNKRIFFVTILTDEFQLFKPEFLFAQNSLYFYNFYFDNIKDLFQKYGGENVNLHIIHMSFIDLKDFLFEFLVNYSDDFIYSQNRLSFTEIIHKERESISDFTKSLIQQMSPCCRLWFSFLLEIYRLYLRTEYFKCELTIFAFEISLVSFQEIYNDFLEKLETNKKMFLIGQEEMEACRDFFLKCVLFRIKHLTEKFDKRSILSIDFEIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX1</accession>
    <name>A0A4Q9LUX1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1139p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="PITK01001139">
        <property type="protein sequence ID" value="TBU11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1139p0010"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="382" mass="45688" checksum="63FA4901EA1B4310" modified="2019-07-31" version="1">MEIFLSKFRNLSGFDIKSIRKINTPNEFKDFVCENLKEASVCFMMSLYIGNGEKSMEIFDALVERKVKNLETVIVLDKNRGKRNSEILNVIKDKNLEDFFYFYDFKKYYMLPAKIRELLYVYHPKVYIFDSNVILTGANLHDTYFSNRIDRYFVVESEKFSDYLKNEMFYKILPSLGNYTKLLDNSSFVVEILTKTFILMFDNRQEEEILRKILLEDFQDIFLSTAYLNFPETYFDLFNYKNISIVTAGPECNTFDLNNKNEKYIVQLYSLSAYKTLDRLNNMQYYEFGRKDTTFHFKGLWAFSNGFALTVIGSTNFNLRSNVRDEERNFLIVTKDEKLIQIYKEEIKFMLENSRKVELEELKNRKPSLLSKISYHLFHRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY6</accession>
    <name>A0A4Q9LUY6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1222p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001222">
        <property type="protein sequence ID" value="TBU11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1222p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11055" checksum="6CA91A447DEF89DD" modified="2019-07-31" version="1" fragment="single">KSTNISVKHKDTKEFFLFILHKANTFEKNNIYGSSHKRVLPDNGLREVIGNMLKNAIDSSEKLRDILSLFSNNIEELQQRLNQLLLRLETDKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF1</accession>
    <name>A0A4Q9LVF1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0709p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000709">
        <property type="protein sequence ID" value="TBU12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0709p0010"/>
    <dbReference type="OrthoDB" id="2192790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19253" checksum="1096600151C7CA5B" modified="2019-07-31" version="1" fragment="single">MTGEAKKFSEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTLERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELQSEHMLLQLLDCLEKSKEISTRRAAILKVENNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF3</accession>
    <name>A0A4Q9LVF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0676p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000676">
        <property type="protein sequence ID" value="TBU12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0676p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020394276" evidence="2">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="468" mass="55994" checksum="FE5AB3D963C43FB7" modified="2019-07-31" version="1" fragment="single">MHLFLFLFFLISLCFGSMSEDPKTDNEACHSKRDTSDSGKKNKSEYNISKDFHLIVMTDYQDAIDTISLKVPGLKDILRSYLEKMEDLILECINKTLNKQIEILKKPDNPNIFKSKIYEAFYLDFIENLIFDLSSLTEKSFYSKENLYDFKKTVGGVFKQIKHKIHCEMPYDIARIKAANKAHVYNETKKEALKLVSNIGKNNDTKKFLIEKSFEIFKSSLYLLNKEILGSLFFKSKINDDFINKEVENNKFLKNIRTMHEKNGWPIPNYYTMSPLQKNKEVFDLFFEMLFKFMTEYYFNKMFPDIFTHKRLFLLWAHNGSEPGVPLSIKIRDNSFLPVVFYDREREYLDLAFNVSFCRNLYLSFYFRIEEWLFIFIEQLLFCVGKEKFVEIMKMDLPADIVERRKQTNTVFEKIYKDRKIFCGEIKSFLIKFMIFFRYYTYVSFCIYKVQDIDLSDISNKFFKKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ0</accession>
    <name>A0A4Q9LVQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1081p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001081">
        <property type="protein sequence ID" value="TBU11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1081p0040"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="165" mass="19127" checksum="6A2D3E3C10E70346" modified="2019-07-31" version="1" fragment="single">VETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQYIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNRPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY5</accession>
    <name>A0A4Q9LVY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1019p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001019">
        <property type="protein sequence ID" value="TBU11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1019p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19924" checksum="C7E38C4B86948F2C" modified="2019-07-31" version="1" fragment="single">DIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLGNELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNIEVYIQSIVLKMTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPSLKEAKREEDGVKILKPKNNTPLISQGETTLQEPPNNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW21</accession>
    <name>A0A4Q9LW21_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0582p0010</name>
        <name evidence="1" type="ORF">CWI38_2136p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002136">
        <property type="protein sequence ID" value="TBU09587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000582">
        <property type="protein sequence ID" value="TBU12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW21"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0582p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2136p0010"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="28670" checksum="BE1A76463E719EC1" modified="2019-07-31" version="1">MLNIDINTFEEYNFLKTKASKNELYDIIKIGIGLNMPQETISYSQFLYYKFLNKNITKKNISFISSCFLLSSKITGTFKNLKEIIEITKNYYSTRENKNNDNNYDINESDVHNDENSVNVLEDAQDTELEMCIQIDFDFTYNNFYQYLKKKCNKFKFDMKRQQCAWILLNDSFYLPFSLFFSVKNIVLACIYITLKIDELEKFLNDDIKDRSFKSECDIILADMEIRFIVEEIIGLYENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB5</accession>
    <name>A0A4Q9LWB5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0950p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000950">
        <property type="protein sequence ID" value="TBU11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0950p0010"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="18584" checksum="1E6ABE1214DC9A67" modified="2019-07-31" version="1" fragment="single">FNYNSYVINCLTCSKIYRTTEIGINTQFEFKCCGCYSFISLTLKDIQYKTYQKSLSSKIKVGVPLPENGTCIHYRKSFRWFRFPCCNKLFPCDICHDKETDHCNEMANKMVCGFCSKEQSVKNNCECGMTMKKSTAHWEGGKGTRNKVVMSKKDNKKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK1</accession>
    <name>A0A4Q9LWK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0906p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000906">
        <property type="protein sequence ID" value="TBU12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0906p0030"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="6">
        <location>
            <begin position="311"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="52533" checksum="D855C1AEA725BDE6" modified="2019-07-31" version="1" fragment="single">ENYSLEIEDKNPFIKIIETDNSITSVGVNSNGIFFNEKNVVKKYKKEKMKTFTKHMSNITDICIYGDNVYSGDICGGIKLISDKRQVLRQYDEHEGRINQIIILDSTLVGSCSDDLSVKIYELSQSESIKTLTDHTDYIKSISVNSNILGTSSYDKNIFFYDKNSFEKINFLKTENQIFKINFVEENLILVGEGCFLSIYDLRNNKCVKSVQVHDKEVSDVMVYEGRIYSTGLDSSFKVFDMNLEMLDELSFESSVLKFTIFNDIPYLGMENGEIKSLKVERKIEKNKNLKKYNKIRYFTQFKVEVDGIENKFIKSNEIKSMVKKHEYKKCFDYIFEKNELNLIFGYLKYLEENNLLKKIILNRTENELIRIFDFMIKYFYRKEFFVIFIKILKIIIKVYKSIIFESMNLSEKILCLKELQEENDECSLVYTNIFKKIDCLLSKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP0</accession>
    <name>A0A4Q9LWP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0911p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000911">
        <property type="protein sequence ID" value="TBU12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0911p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="20853" checksum="93AB0028BD97807C" modified="2019-07-31" version="1" fragment="single">IFILDKKKNKITLIEVGITSQDSLQIDLLANELGLINKCIVEIIPYVMTWDGNVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAKESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTLLISQRGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV8</accession>
    <name>A0A4Q9LWV8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0493p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000493">
        <property type="protein sequence ID" value="TBU13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0493p0020"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="39134" checksum="FE9A3A3EC4A4D1E1" modified="2019-07-31" version="1">MPKIISGKNRQEKEIITTFLKTAEHFTLLGNDICLKRPDHLIRAVFGFETALIKQIIQTELAVAHIGVIRMMALIVQKYYGIPKAYIKEYVKDCEACNLFMMDCVDLRIYSDRNDQYSWILNVIDTYTKHLWSFKLINKTSKLVRDSLKFLFNNFGVPVTIQSDNCQEFKNALFEAFLTDHNIKFIQEDHASQAQIQKSHETGGRREMEHFSNVVYVYNRTIHGETNISLFMLFFRQPVENEASMIVRRKCRYTQWILEIASGVHEEFTETVTTTTTIIADHLEIDSKIRSNVAKQFKNYREIIIDSNNSNRHKRDLPTKDIVLNKKRPRYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF7</accession>
    <name>A0A4Q9LXF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0422p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000422">
        <property type="protein sequence ID" value="TBU13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0422p0020"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="31328" checksum="B81A3B5973935295" modified="2019-07-31" version="1">MANLTQKEENSIPYWKLNANEKEFLYYYCLTKMEKINQQTRYKKIKCFLAKNLCCGKQQIKFPKSKRLEPIIFELIERVVNSEPTVAYLFFHREKLLDNDGIRLYIDTIKQYGVDIYQIKEIANLLISLIKVYDGLFHRELAYPLHKAMFMKPNGKNIEFFLYYMRFAFTEDERKLFTELRRMFIYLSNNNSSIYRSLLIENVDMYFPECSYFTKSNVNTQAKLIDYFNDFNFHSVPEELLKKANDKLHTMILKKSRNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL5</accession>
    <name>A0A4Q9LXL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0752p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000752">
        <property type="protein sequence ID" value="TBU12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0752p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="36980" checksum="F9390319145EE575" modified="2019-07-31" version="1">MIWDGLVTKYYKSHLKRLEIPVKVEKYIQPIVLKKTSGLNVEESYDGASMGRITLEDRVINITEASDFEEETVRLEETVLAVLVNNKSTFMPIIKELLQSVELRSEHMLLQFINSTILVVENTNKTHLAKKRLKNVEYKLEERKPKFHSKLYNAEKKEPVNDSVSSGWHRKEILVQEILQNKHVEIRVNTGIKIDGLIYKYSVDIILYVYIHSILLNKTVKTIFLDRQSGFESGLNAEESLERASMVLLRYRRCMGINSPLKQTDNEKYDDNTEIKNYFFFYYEWLKTAEGPTINENKKSDFEEDSELVKIELQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM1</accession>
    <name>A0A4Q9LXM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0688p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000688">
        <property type="protein sequence ID" value="TBU12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0688p0040"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="514" mass="60848" checksum="F4336E5409957B31" modified="2019-07-31" version="1">MKKKSEKVVKKNYDNFMTEKEKKYVEMVLSRNISKMERRMDYSAFFNFEDKGPIEVKKNEKKNIEKREKTEGEANIPIKEFFRETLVRTHKKSVKEPRFVADMKAPEDFSELAIKIKIEEIIDVLIKRKYFVNEEPNYLEVNSKEFLKNINSEEFKNYIKIEKFFSFLNRFFDIFTDIERKEVVVLLCTNSNSLMITESFKLFINSNFMYFPSLQHHEIIQFLNNFYLNTPGIIIGFIMLHSNNLLEKVMYDRLIEDDGVNKLFLNCEEGYVWQFLALLIGCLDENNRRNMVFLLKEKIAEVVMSDNIERIRYLDVFLDSIGVSKSDLESLSPEILDNEYAEIRITLIEVGITSQDSLQIVETEKIRKYDLLANELGLIYKCSVEIIPYVMIWDGIVTKNSKLHLKRLELPMNVQAYIQSIVLKKTFETISFDRRRRHDWESASIDVIMKSEMYGEPSHPLKQASREEDEATAFEELTININEESDLEEETTVVKEVEEMDKNRKTILTQHFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM4</accession>
    <name>A0A4Q9LXM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0424p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000424">
        <property type="protein sequence ID" value="TBU13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0424p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="61" mass="7183" checksum="E166006DC0A76811" modified="2019-07-31" version="1" fragment="single">MNGDSNFFNEYNKNVVLSHNTKKNDHSDMTFDSSRTKEDINREFDDIKLKICGECCDIYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY05</accession>
    <name>A0A4Q9LY05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0702p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000702">
        <property type="protein sequence ID" value="TBU12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0702p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="29459" checksum="C4B17E0F10561DDB" modified="2019-07-31" version="1">MKDCIEQFIRELLRPFKSYEKKKFYTRGAYSMSLMSLMSADEDAPKQRLRSKKSKIKSSKSKKKKSSKQKTVKDDRNVEFKKSKGLLNVSKISNGKPMQNESESVSTLGKLFKQDFTPNVKLKKTPKTKKDKKHKKSKNTDKEEDYSLLLKEYESSATEKKAEEHIITPFDDKSLSDQLQFPLSEYFSPTNKPDEYDNSAEEDISKKDKKQKKSKKKINLKIKDMNCQEDSSDFNIIDEKISMGLKEYLNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY11</accession>
    <name>A0A4Q9LY11_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0379p0070</name>
        <name evidence="3" type="ORF">CWI38_0384p0070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="79"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="30246" checksum="CC8FB1DF70996F29" modified="2019-07-31" version="1">MANNSEDTNKVRNRNLKYIAAVLICLLLASTLLLIGVKLFKEKNKNENTKNTSQENILSDEKVCSKMQEDFVTYLQGQKKINILKFRFDTGLSYAGMGLTDEAVTHLAIVNAANPELLPGLGGLNKGITVWVREREGLSKNGSSEVWNNLTACAEGQTESTKKLGLAAYSRFNGGILLHVIGPQGSLVGNPQQCKNLSEVTELLTNAYKNCLRMANDYECSHIIFSVISGDLFCQSNSKVGFKKSEFLCAIQNAVKKFIEKTEFKNIKVYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY80</accession>
    <name>A0A4Q9LY80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0673p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000673">
        <property type="protein sequence ID" value="TBU12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LY80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0673p0010"/>
    <dbReference type="OrthoDB" id="1751077at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="182"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1399" mass="162207" checksum="51DECFC8926E001C" modified="2019-07-31" version="1">MIGKIKIQDALNNSAYSDDSLNKTLPFQSDELIRLFNSLEKGSMMNKKLLPVHRHLKNQMITKTDVSDKLAVICTKIDALANFKILFCEFDLKYFVRSKNSINKCTSIVKMENIRVINQKNVLKKYCKTSLRALEYKETIQYFYDKLEYNQRKKISSYCRFKLLEKPKKRCDCFLEMLKNIFSLGKNSKIDQKIPINPFIYEIGEHLLANGVETEGIFRISGKASAYRTVPNVLKNNKRYNLNDFSIHDNASIFKAYIREILNGLIPEYICGELIATIKGFPSHKSLYNLVFYSRFCFDEDVRKLIIFLKKMFITIEKHSKYNRMTFENLVKIFTPSLFPNYKHFDITTINTQIERRKKVDRENIKNEEIKAVNNSEISLKETKTCDIDVVTISETLPPQPTTHNNTHSPSSNTFRVTPVCLLDSNSPNTMENLNAPAIPEGNRLMVLHSILDSVTARMPRNVWSAILRYYNGKFGQTVDIDRRRIATCLAEQCSLTDTTLYMNLREKFLCKIKELSEKEIGDVVVRTRKLQSELVDSKVLELINRITGEYAEFHVPKNVKEKIESKISKLYFSKDLIEKARKQEKHSTSETESLKKNLREFNLDLSKINDLSEALVKKNKALNVYENNFTMYEIGSKFQKKNRMFELFRGRFYRGLSERVESEHVVYRDEISEFWSTIGNKNDKVVTYDEYLIPFVSDAQQTTFPSLKEFIDIINCCITRKPQELMKLTSLHKYLYDIVKVIFLEGTPQADYYYCGLTYLIPKGTPKTGSDYRPITLVQVEVERRGLLSDNHARSEITGSIQVAINKDKKIERRILQGDSLPPLLFVVCMDPLSRKLNEKYTKVTVQTNAETHSTNHLLFIDDIKLLAEDGQTLEEMTEEVNKFMNNIGLEINREKSATNDPCCEDTATLLERIIVYKYLGIIADSRGIQTSKSFEEVQTKLIARVERLCRTRLNARNLFQAINQPAISLINYHIGVLRLESADFSKLDDAVHAVLVKNKIHLRPGCKERLYLPRKELGRGLHSDEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSLIKNFLKIKYGFEEEVTKKKLEEAQLANLYNEIKNRKSHSKLYSARNNELVSVNDSSGWLKKGSVRPRDTAVFCYIQDRNVFWGAEGMCQHCNTSRKTVDHLATRCEKMLGHDYTRRLNEVVRSVHLLFLNKYKFKSSKRIRSYSVQEILDNEYAEIRVDTRIKTDVKIRFETEKLRKYDLLANEEIPYVMTWDGIVTKYHKTYVKRLQIPINVEANILSIPLEKRIETISFDRRRGLESGPNAEQNRGRESLSVVLGAEMHEQSTPPLKQVVNEKDDEPTTNTKEELEGEGEIEMVEMKKCSSENPVATENIFKTIFLNLADTVCPKSKCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH6</accession>
    <name>A0A4Q9LYH6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0325p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000325">
        <property type="protein sequence ID" value="TBU14447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0325p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="87702" checksum="27B31EC83BC36B57" modified="2019-07-31" version="1">MKYHHFCSLFLEYISEGICTARTVTFFFSKTDSEFTGETLFVEELRLSNEEKELFEKLRPYRAIANKLKRTTDIPILTTNTQNNSIRIIYPGNIKFKIVQIENKIDSKKLAFYVGHLITKEVFEFFIEIICDLTDINFYLPDFVYWQLINCILGLIPETNVYFRKLFSRLNYWAFTGKYLNGIIQNQNILVFNSCIAVRYFFITALISYLNFINISVTFDNSRIVLTSINGSTHDIYPSEECLNQELVLIFEGRSLNIFFASINAQNNKQLYDWIFKGINNIKTIIFSNCNFSNLININESINCLIYKDFMFLKLKNCLNVKNYISKINEFRINKLRNMKLENIQLSSVDLISFIEFKKVAKIKLENCTCDDDEIYTEKILVIFIIEIKNMVIDKLIHSFFKKACFEFLILDKVVFKYPFNISNIPIPEYNKFASKIKLITTNMNDNFFDLLYNYKSLLSIEMKSVGNLSFRIKKNINLNFLKLEELALKDFSLPKKIHNIQFLPNLEFLTLYRIQNISSLFYNLNEQQFYDTLRTLKIKGTPLTHLEIEKILNFSRLENLKLHTCNLDSSHLLNLNKLISKKILRRLILTNNKIKNIPITCKGMFNHLEHIVLDRCGLYAGSVSLFFNDTKSNKISFLDLSHNSLNRADLIVVSGLIKLQVLKLNGINLQEDARLNNLTTHGLTKHLKFLEIKELTISAKDILFLSKFKVLEKISLSESSFECLKNTKVRICCSNFDVDSVYELEMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN2</accession>
    <name>A0A4Q9LYN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0289p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000289">
        <property type="protein sequence ID" value="TBU17015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0289p0030"/>
    <dbReference type="OrthoDB" id="2190422at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="590" mass="70893" checksum="B90435684D332979" modified="2019-07-31" version="1">MDEIYKKYEKILNFSEVKRNLNIKKEELDKNALKIQNLKKEEKNISEKIEKIRINEIISELEKLRLEIKKMEIVEQEICDIKTFKNLTKIITDKKIICGKAEKLFYNYFCIYTGKIECIIGQNEFKKQIFHSLDISSDLFICIFSKELEIFFCFLKEFDNEIYKNIKKIFLSFLKRNFKNINCENIFLFESKNSICVVYNYIDTSYPEKCNLIFSKVDEFDLSKYKETNLNLMIDKYSNICKYLANILFENLKKYILKNKIEKNKLKNSFLVFSNTKYFTNDLDRFILDILMKNMIDLSKRDRENVELQEFKSQNHQIPKIISKNYLKLITNFKKLNEIDIHDNEKVFDTIMKIFVVFFSQKKTYKSLTDLFSLFCDLTHFIKLYESIFYDESKDKNSENKNFNNFLKSKKEEIKNSIQNLEKSKKKISKKIFEKGGQIDFIFLGENTKEFKSKIKMKYKLFIDILNLMLPESMKLSIEIGYSEYIYMQYIDYVLFLPEISYKECDTLSEVGQFIIDLESIPKNYISNYPKILAISEILQMNLNELEIYIKKNKNVFSYTEISGMVNSMFEESEKRERFLKNLKNYLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ1</accession>
    <name>A0A4Q9LYQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0284p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0040"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="29960" checksum="CE10FE571ECE0743" modified="2019-07-31" version="1">MENHACIYHPFNPDYTLHDTIHLATRCEKILGHDYTRRHNEVVRCQHLLLLNRYKFKSSKRIRSHSVQEILNNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEAGITSNTDELGLIYKCSVEIISYVMTWDGIVTKYHKSHIKRLEIPMNVAAYIQSIVLKKTVETISFVRRRGLESGLNADESWERASMYVIMRSETHEEPTKNIILLISEEGTALMKPTNSINEESDWEEETEVVKEQKKTCKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV7</accession>
    <name>A0A4Q9LYV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0524p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000524">
        <property type="protein sequence ID" value="TBU13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0524p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="36797" checksum="C55FB7FA6F519E9D" modified="2019-07-31" version="1">MELEKSVIFSFVFGSLCFGYLIILQYIIKSNYNTFVFTHTLFVSIISFILNFIGRDRKVRIIQIIPIIFSILYGVLDYIIIICLCNTLSSKSYAYILIFIGIILFCLLLMTMKLTIMILPAFFLNYIFLQLFIKLEVFEATGTGFSLENIEFGLVKNDMSSYILAMIAGIFVRFMAVKKMRHHTSDRNYGVLSSFWMVVVSVICVLYKYGDFVDECKVVSKYPLSFIGCGILGALSHFLMAKYGKMMDFHYILGFQAVFCIVGQLAFFAMKNYEFFMKTVVEKELSMIYLPFLCISISTLLFLYPHKMYYYWDDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH1</accession>
    <name>A0A4Q9LZH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0226p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000226">
        <property type="protein sequence ID" value="TBU18875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0226p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10059" checksum="92CE930B7150D966" modified="2019-07-31" version="1">MEYFTDIIIFKNKISPFKMYDVIQAPLELKLEKLSFKIKPNVIFTVDSVDYVCELKENIKLGVCSDMGDTTGEIIKNRNYYVIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI5</accession>
    <name>A0A4Q9LZI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0459p0010</name>
        <name evidence="2" type="ORF">CWI38_0637p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000637">
        <property type="protein sequence ID" value="TBU12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000459">
        <property type="protein sequence ID" value="TBU13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0459p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0637p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="779" mass="93777" checksum="C32532E2745DA27B" modified="2019-07-31" version="1">MSIFYLKGHLHSLFLCLNIYFLLVYCQNVIFYSIENANIDIDYVENGKIDSFKFEIKSMYILNTFKSVYLLQNQYLKCVYINNSYKYYIPNIVEIPGHENIILNFSAFDDEQDNVLTSKIFMGQISYKFLLRFIKYSTEEDAFINALSFMEFINILTVLEILGFKRTKNNNTFLKHLLVSSITNESFHSSDMFPKLPNSDYDRFQLNLEYLFSVFLKFVFIDKISNYTFLYFKNNSSSKDPLKNLSYRGYIRYKERLGNDNIIFLESHICSHLEKLLKYSWIKNSIICFIRHCNVDLYLIAMKMGKLKPMISNFIDLIKPDSLKKLIITDNVINKPTLKVLIHYEYFPITKFVKIICDLDIEEIHLILRNSQNIKRLIIESKEACYNIFFELKKHAIIHKNLNIKYKCNILIMQCRMNDIFQNLPENLSFYIRKFHISFTHCEFCMMKSLTFFRKVLIKYNTKKKLKKYKNQFYNCINTKDVYISTKQNKPEKIHRKIFKYIFRMEKLESILLENIIIPEILIWHILESKNLISIKLYNSCIPTHFSHDYNILNYILRSITIKESKYTLNDNFFKFLLLFRNLTFLKLYIKDIDSDFEMRNKHCTSRIINTPNDNLIVKLEYLKVNIKEETIIDWSILFAFSNFFDISNLNILILQMHELNEKDAFIISNLRSLKEICLSIYRQKTEIMLKRLTKILENKFIKRIRLDICNLNNYMFEYIYKFKNFDMVFIHFQYFEAYDLNSLHRIRCNYPNSVIFLYEYNRLVSSEVKCFLKEHNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ1</accession>
    <name>A0A4Q9LZJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0318p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000318">
        <property type="protein sequence ID" value="TBU14952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0318p0020"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14728" checksum="72F82A8D7E78AAEC" modified="2019-07-31" version="1">MNYGVILILNNIFDIRAIVSCNLYLKKDLYYGNNFDSDLKTLKFQTEKNSSDEETCTYNLRKRIKLETNKPVDYSKYQLFTLNDVESLPFVFNKLKKNGNSNIYEGDIILENIIYSDFVFFMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK6</accession>
    <name>A0A4Q9LZK6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0314p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000314">
        <property type="protein sequence ID" value="TBU15250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0314p0050"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU15250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="35123" checksum="EA14F182ED0825AB" modified="2019-07-31" version="1" fragment="single">EEDNPIIFTFQSDRKVKASLSYPEICSKIIGADTIRGSRISGHRGYFLMGELAYLSLSLINYAVDFLKEKNFLLIQPPVFLNKDVMAKTVQLSDFDEQLYKLEEDLYLIATSEQPLTAFHYNERLDPSTLPLYYCGQSLCFRKEAGAHGKDNQGIFRVHQFEKIEQFVISEPSQSMKIFHEMVENSVQFYKSLDISHRVVGIVSGEMNDAASIKYDLEASFPGSDRYRELVSVSNCTDFQSRELEVRFGVGKENAKKVYVHMLNGTLCAIQRTLCCILENYQSEDGVIVPEVLRKYFKKDFIPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT8</accession>
    <name>A0A4Q9LZT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0186p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000186">
        <property type="protein sequence ID" value="TBU19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0186p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="29532" checksum="2A50E4E58F169D8E" modified="2019-07-31" version="1">MNMSLKKNKREYAKFKRNQRYRVYNMVYNFIILCLEWIILLVIVLAFCLRWNILDQEFPLKTIFIKYYIIAFLLSLSDLLNPFNSDNNRSYDKYDLTTLVLIYSSIISEILIHKLNFSSLWNFDSKAKAIYAILNILSYLFVSFRYNNWNFIQKKVSFELFLEFCYFIFVMISVNNIFAKVFYITIADLVLFKSLSYVFVIIITFIYLIRKNSFKQSFLLCMYYSLLLFSLEPKNIQALHNIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT9</accession>
    <name>A0A4Q9LZT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0184p0060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0060"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="11">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU19864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="32398" checksum="710133A1694A0F40" modified="2019-07-31" version="1">MALKENIEVEFNEKDFKHNFLEQSEFTVMWPRYREEYLKTNEKLLQEKLQEIKLSLDINYSERYFTVSTTNKTRDPYIIIKGRDMLKLIARGMNLNEASLILKDGFTSEIIVPKELKKEVFLKRKARLVGPNDVTLKALRMLTDCHIVLQTDTISIVGPFKGVTQVVSVVDSCFYENIHPVYLIKKLITFKELQNDKSKKDLDWNIYFPQIKAKKQKNRKSKIDKREKNDKMPLPPPKSNLDKLIETGEYFLDDKKDSKKRKNKKNEKYILPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU6</accession>
    <name>A0A4Q9LZU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0318p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000318">
        <property type="protein sequence ID" value="TBU14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0318p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="19623" checksum="EDAF42DF1E026415" modified="2019-07-31" version="1">MKKICLYELGSTHISFKNLLLVISNHLERIELFSSKIDIEMLNFLNQKDILVSLKSIYFSSPINKISECAFTGFNNNLEVLFSKNLNDFIVLKPENENMTLFGIFHTIFNKNFRKNIILSENFEYSFDSNESNVNINLDSFKNDEMVKLFYIVSNNNIYRKNNIFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A6</accession>
    <name>A0A4Q9M0A6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0140p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000140">
        <property type="protein sequence ID" value="TBU20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0140p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="41837" checksum="537D59F2D694601E" modified="2019-07-31" version="1">MLSDKDIEDLEEKFSDSFIFSKESKFKDSHINNNYDNDSFLFSKESKFKDSHINNNYDNDSLQHFYDFSKIKTKGILQEKNIFKDKTAKKTNTHNTNTYNASNYNASNHNINSYKTDKYTHNETPRKTNNNVNNYKKYQENLNEEPISYKNINLHKKNNSEEKDSLIHTNTFTISKSIKEDINEGFNNKNYQSNNKNIVDQPLNYKLNKENTNENHNSKSVKNNLTDYKNTENLTKLQHELDNLKDTHKRMLQIKSKLLYLIDIEVQKVKKSIIFKKNEEIKSIINKYQSIILEKDSIINNLKLQANDKIDINNRDDKDELELYKRKVEKYKDAYIKLKEKYKRDILNKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C1</accession>
    <name>A0A4Q9M0C1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0136p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020922798" evidence="2">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="14451" checksum="0F16BD1FF321E77F" modified="2019-07-31" version="1">MKTFAIFLLSFLVLFKQYLASAAEGGAEGEATGAESGGEEGSEAKKEGEDKKEDCLTPGTIKGIEPGKAVVCQKPGGPVEKDKNIPEKPFGTKTENPGTTPPVRKTESTLDKSSGDKASKEGGDSEGGGDKAASGGEGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D6</accession>
    <name>A0A4Q9M0D6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0134p0090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020219483" evidence="3">
        <location>
            <begin position="21"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="543" mass="62942" checksum="3EC0477E7AE5BB95" modified="2019-07-31" version="1">MVYFFVKYIIFVSTIEIIYSSATNEDKCDSANTDQSNEINTEESCFSKVIPRIFGKKFILETIILKFYVSCGLLEDRLIKLMTELKKIEDDISKEEEMKKCIAKGTKPREVTLKKQTVSIFPFMKHTENDQSKKNPELKKSVSFRYFRRQSQKNNTSNSIYGNDTSSCMPPEESANEKDNLSKQTPRASEAITIPIKCENVRSFSRFFSRRKYSENSESVISSEGEFNDESLDKNFTSFDFEASSVTISSRFFPHSYKSDGFHSDLSPTQEEVVYNITRDTKASIDFEKIDEASLHKDLCSLKICFPMFFFEKNLNCNKIKYIAMSSYVDIKSYDNLKKYCFLESVLSEAIEVMFRYFTKLFMTLNLNIYGTNNFDDIDTKCKEVQNILWNFLSNYIFNESNSTREYDKKSKFVIFCEMKAVLARITSNRSNIISSFSKFVGNIASLDKIACLKEKFALICKLADYLKEKEPILKKTYLKTSKILFESISFLIKNDGSPFILESLADSGFLKKYFEECVEIEDINNCFLDKFILTLFPGQTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G6</accession>
    <name>A0A4Q9M0G6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0394p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000394">
        <property type="protein sequence ID" value="TBU13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0G6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0394p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="26559" checksum="C506B58285BB7F10" modified="2019-07-31" version="1" fragment="single">KITPVITTDSIPVTNTLCLTDTITDNITRTRTKTVIKTITDRERESSEIPTNEKKKYTKTIATTVSRSDMTPLIETVPQEKECLECKHVTITTYLDKRKKKRKTVVNTIYAKESVSSCNKKDKSICLDEKGKEIVTTIYVGTNKKFKIEHKDIKREYNDPKKSELKNMYNDIVECIRFFENKKNEELLEGGNFRFFITYNSRQKTPKKENGSYVQPYSSGVVLKELEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M8</accession>
    <name>A0A4Q9M0M8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0115p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000115">
        <property type="protein sequence ID" value="TBU20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0115p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="355" mass="41474" checksum="36E9510A729AD568" modified="2019-07-31" version="1">MYESLNRKLNEKYTKVTIHNDADSHTTHQILFIDDSKPFAKDLKHWKRVQRRIGNKKIGVAEESKHLNRFMKTDQSDLRNAKKIFSEINQHAISIFNYHKGVFRLEPANFSKLDDLVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSQEISTRREAILKEEEVIKKNLEEAQLAKLYNKFEKRKIRAKKGILGHAIKQFSIIFRIEIYSGSRWYVLALQPIRVDTRIKTDITLIEVGITSHDSLQIKTVEIISFDRRKGLDTERASMCVIMRTEMYEEPTPPLKEEKREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINEESDLEEETKVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N6</accession>
    <name>A0A4Q9M0N6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0387p0060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000387">
        <property type="protein sequence ID" value="TBU13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0N6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0387p0060"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="310"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="434" mass="50661" checksum="4D747146BECBF9A4" modified="2019-07-31" version="1" fragment="single">LHTENSSSTAVNLGYAKVLYSCGKYKKILDLFNEEKNESISEIVENARMNKKKAERNLEENIEDLYTESPYNIEFLEKIVLKKIKKNLLVEALQLLSSKKSLVENNKKLLQLKALIFVFQDKIEAAEDIFIKEFRDNKTMKQFKSIRQEYKNIENIRDKRQRFYGLRDFLLKIDTLDLGSLLPVSIYHNIKLGALKELLSIGIHFKAKGLVPKAELYNKMADTDNSRYIYVLAYLYSGNISEAYSLVETLHFEDEKYRSSAKSKILTEKQRMKEEEEEERERQRQQEEWQKQQRRSRRGTKKSDDPDPKGYYKSLGVQKTATKKEIKKAYIKAARKYNPDLIEDAKEKEKMTKKLMEINSAKSVLLDDEKRKDYDDGIIEGEEPFAQDFDQKQFSDIFSMFFGGAGGNMGGAGGSRFFSSSRPGQQQTYYYYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W6</accession>
    <name>A0A4Q9M0W6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0195p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000195">
        <property type="protein sequence ID" value="TBU19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0195p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="28042" checksum="C11FDAFE72A24017" modified="2019-07-31" version="1">MKFWRNKFFKICSIIVLIVFIFVAIICITGYRKANALVENFQTDVNDCSETDLFKKLLGVLKNYKICVFIKTVYGPNTAFYIPVFRNHNEVKKYLFKAITNKDEKKFKGVKSSADIYLCGSVDLENFSVPEDIDSITKIGLWFKNKQVQKTIEEIRDHIRNVLNETKENQLNIVYLNIANDETVEVYNVSASYKTDQIYFLSFKSFEFSLETKSTEELLDYMTFFILKVTGGRFKDTNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X1</accession>
    <name>A0A4Q9M0X1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0092p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="48763" checksum="83E35F146BD8B035" modified="2019-07-31" version="1">MYFQGFVYTENFGLVVLLFLTCKSSNKLRVKSKSILDLPKDEQRGIYSSRNSASGSSDISTHGTTVHVSEEVPSTEGKKRLIYTSEFDGSYSPHNTNDIIYLKNINSRSKIRLVSKNSSKNKKGKCELENILMSEALVDDKYFSVFSTLNDIKEKYIEFSQGKIQECERIFSKILQDINILLIKYVNQFILTDIIYTSDKSHIRVLFALKLVKSIITKSEYEIERILDSFTSTNIKNIDFDIEMKQIYENIFFKEDNSYLLDIMFRFDESDINEIYTLLQEDKNNGTGTSNFDKHLKSRSRKLSDHFISKIICYYFQPFDAKYVEKKFMELKPRFYALAQGYHTNKPIENDSFHGIVNDTYELIYKCGVNNISYVMTWDGFITKNNQSYIKIQRRPYKCRRLIQCKSSKQSLSNFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X8</accession>
    <name>A0A4Q9M0X8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0350p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000350">
        <property type="protein sequence ID" value="TBU13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0X8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0350p0040"/>
    <dbReference type="OrthoDB" id="2192095at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="35839" checksum="93E857DA78D83C4D" modified="2019-07-31" version="1">MKRIRNKKFETSAAYYVYDEKEIDINYIQDYIPPSISTGMEAEEEKEIHLKEIISGKKEKIPIPLIEYTENKEEENLFKRGKEYIKYTEDVPNEYILDDEDIEFCKINNIPDTELIKRYSSGSEDFIINYLQPAMLKFNDDSSFNPYVCFRKQIIKTGRRTRRSEISCIDKMKRLHSEFTIINNIYNSSLNMLETESDLYKTKYQILSTATKAMLGTSSRKRKSIYRSVLGIQKPTKFIPFYKKLLNFDNLLFDRKKIQEYKTMIFGSEKNIEKMDLDDEVNFILQRKQNNFISKLVNKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D7</accession>
    <name>A0A4Q9M1D7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0170p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000170">
        <property type="protein sequence ID" value="TBU19927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0170p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="29154" checksum="65FB9D7DAF06250C" modified="2019-07-31" version="1" fragment="single">MLLITIPRNLKLFISTLRAINLKSNNIFYLDINDYTRRHNEVIRCLHLLHLNRYKFKYSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGIISQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASIGVIMRSEMHEEPIPPLKEAKRKEDGVKILKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U8</accession>
    <name>A0A4Q9M1U8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0129p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1U8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0030"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="122"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="856" mass="101671" checksum="EAD5EEEBD84CBFB5" modified="2019-07-31" version="1">MDGKIEISQQTKRISYKTSNGYVFIQGKQDTETSNKNCFETDYSDTLIDDFCCAIGILEIKKNEETNWYFSYVSRCNFVGKFNEINIYKINKIKFYALKKLGRKEKNENFSDEDLSNENLRMAGFVQTHNFYFMKNSDLEKNTFVSDFLENEKFIWNSIMKKRFLKISEENLEIQLFFEGSNTKSGDYNDLGIGIMVCGFFNIKYVPLKEYKKEKELNFNSKEIQINSKDSLKTLNLFEENILIQENETFKEERHIYSDKFEIQLLSLISSAKVGPRLYCRGLDDNGNVSFFVKTLCRIYLKENIIFEITLIRGSIPLFWYQEKNPLKFEFKFSRESEISKNAFKRHFDHLKTKYGKIHVWNLLGKKRGETKLSGMYEECLLNQNIPFTSFDINNYTGNFRLLKKIFMEKLVRIEDKNVIFRVSCVDCLDRTNLAQYLIYEYFFYQILEKYDLNYKIIENVKLNLKTIWVENGHILSYFYSGSDAMRSELALKEKRSFVGMIDDFIISASRIINSGFSDKMKYELINLLLEKNNEEPTIFSEEFKTEKNESPNIFETNLILEKENFKLEKDFTVLDIKNKFENMSLEKCDNNFLVLCCNLNHIPYKSSYSFDLNIPENTNIIIICLQKMYFNVSKMFFKDKSIERLKWKNFLESKFLENNFILAFQNFSYELATLVFIKNDKIDEISSISNKKEKIKFEASTSNTLITSTFIFQNKTFVIINCDFKLNKLDFDKKNLFYLFLNDLQYKYKNKNLLFLGNIDTPIILSRKTIQELIQDNKFKKILSRNYLSIILKNFDDLKEHEITFQPKETLKNGVPCYSYFNRILFLGNFISREYNYIFTNESGYDCIFGFFSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M214</accession>
    <name>A0A4Q9M214_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0239p0060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000239">
        <property type="protein sequence ID" value="TBU18510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M214"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M214"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0239p0060"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="131"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="726" mass="84889" checksum="99EC8E12A55C6A80" modified="2019-07-31" version="1">MDVEFSNTLKIINLLKHNRLSNIKQLLKDEITVYNGVCGTLIHLSVLLRNLPCMKRMLNSISREEGIKWISIQDRYGRSPLDLSIKYNSKEITIFLNEYLDKRNKNIENKLRKIEDENNYEKMIIKGFADTIIKEGPLEKYINFAFGYRNRHLVLKKDKILYYGCRDTGKELKEIFALHEITVDVCENQNSFILVDMRNRKKYIFRTETPEEAVGWVLCIEDTKYENTFDQSFFHFSLVGCILKEYLKIKGENLVCEGIVSFECFTMFADLFEGINIEDAIEKEEIVAMDVENIKTPVIVGESNSDSEKFYDFETENTDEILKSDSLIQVSSFSKEDVRNDEFKVNLGKEEFFDATDGENQEEKNEFLTQERVKLPVTGGVEKKELYSSLLNEKNGKFDIFSAKFPMNVHEPLSLLQRMTEDLIFKNILDKITGISDGCLRMAYVSGFIVSSFFHTKHRIFKPFTPLLGETFYHKLENTDIYCEQVSLNPNISALHAENQNFIYESFLDFSSSLKSKKILINHNGNCKLILKDKNEIYSWKKVDTVVKGFESGDVTVLHNGKIELECGDIKGIIKIKPSKSRDEINVCGSVKQKNKTVYSFKGIWDKYLLCRDMDTGNEFYVYESNERRFPEYYNMTKYSFQLNFITSEIESKMFYTDSRYRPDTRALEYGQFANALENNEIIENRQRVRKNESRPLKPRFFEFNNNLWTWKGCDDTGKGERIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M282</accession>
    <name>A0A4Q9M282_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0233p0050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000233">
        <property type="protein sequence ID" value="TBU18640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M282"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M282"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0233p0050"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="31752" checksum="ED5B0B70496E99AD" modified="2019-07-31" version="1">MKNIRDYKNLEKYKLEFFEDKVIFGFKNNPIFFKIFDGWFIYKDFLIFKNIFTKKEFNKIVNKNKIKIIKRFKMDSKKYFNSEEDKAIIHNYNTNNILEMTKNSINATTEQIKIPLFLKYIDMKSFVHLYLKNSSIHGRGLFANQDIPPNTRIIEYIGELIGERMADKREKTYIENGITSIYLFRIEKDIIIDATMKGSLSRFINHSCLPNSFTKKVYENGISKIIIHSQIEIFKNEEITLNYNFSSDKSKTKTSCNCKSINCRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M298</accession>
    <name>A0A4Q9M298_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0129p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M298"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="370" mass="43313" checksum="EEBD018DB5B8AF07" modified="2019-07-31" version="1">MFEEALLSLAFAIDIPKSTLFDIFKSEKYIKRISSTVIPTLTDKNKIDRLKFCLSKVNLANNRDLLFDDLYDYVHIDKKWFYLTKVKRSYYLMLNEEKPRFSTKIMFMAAVARPRYDAHRKLYFDGKIGIWPFVYQEPAQRNSKKRAKGTMITKNVKSVTAKTIYVQQDNAKPNFFDNDADIVALGSADDWNIQFKLQTANSPDLNVLDLASPHTIDEFINCLQYAFHQLESNTLDNVFTALQACMEPIMLADGGNGYKIPHLSKRKLRPEGRLLEKYVLSKKHTIMPNQISSEHINVNIYFLKFYSIFTLIFIKMFEIKVILNLSCTFFDLFYFFANVYHISGQREYFIKYYPNAKSINKLGYILILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4G7</accession>
    <name>A0A4Q9M4G7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0069p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4G7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0040"/>
    <dbReference type="OrthoDB" id="2193425at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="68686" checksum="FE67DB4583472E0D" modified="2019-07-31" version="1">MLSLNHFLLLRNKKTGNKKKEICREDYYAFYLQTMKLIKDYIKYNDKTSYTPYETLLMFIEDRIDLNISNSCISAHEGTNVPNINEQKVDLNISKSYNSNNEEINVVKSKNDNKKIDYFNNERKAKDFYDFSFFKKNILIQNLKYLLLSHYNTDDQSFKRKLQKYHSYLCLIDLTLDENIPYPLKLSEWLSVNFFVENNNYRKMAIRGYFTQIISKYPDIKPVIESFFEIERFCSFGIKTDEYTEMMDKWKTKYEKNIPNNLKDILFGNLNTENITSIEKLCYKLFFVERKNGKFISKYEDMNHLIDDNDSDYILILKRDFDKLLYRLDGWLRLVLFFVCPMLPENIFNIFYSFEFIGNFLFLIDWKLSLEYLSFTKNFLKYFENYLKIVEVNLINFYFFISLCSRNKISINIVYKYYINYYLNIGGYDEVFNIINDLKCDYIVDDSKFIDYCIKNYENIRNRFVSCEMLKKQPFWFISVIFNLKNNFYISENDIFMALKYASKRKWYEQIFKYLIKYDEIDKSVLAKSLCVIEEIKNDKTMMSDIFAFFSNKICEKLTKMYKKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4N2</accession>
    <name>A0A4Q9M4N2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0057p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4N2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0060"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="40448" checksum="E486C4E423759C82" modified="2019-07-31" version="1">MDILIQKIEELCIQNNININLSLDILNDTPQQEWWNITYIKKSKDLFYKKKEIKFQRKQEIKKEKQKIKFLKIQQKKENELLYGNKGGVIGNEDEDMVRGVTDSREGEGVIDSIYNYKGASNSIDKQQGVNASIYNYKGASNSIDKQQGVTNSIYNYKGASNSIDKQQGVNASIYKQQGLNASIYNYKGASNSIDNYKGASNSTYEQNPLNNSTNTLHPFNNTPHPLTNTNIGVIIFISPLNYNTSYIRKGRSITYNSFILNIFQTKKINENIKYFKKLKFNILWFSYNCYIYTEYKEIKYFKGIENLKEYFFIKGVEGVSYIGIEGVIYIGVEGVGIYEESRGVIYIDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4P2</accession>
    <name>A0A4Q9M4P2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0056p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000056">
        <property type="protein sequence ID" value="TBU20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4P2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0056p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="103" mass="12239" checksum="1E3C825E646127CF" modified="2019-07-31" version="1">MQKFRGFKCINILPYAVNTTELGRVTEFIEEESLIEYNLELHGETNLIPIYSIYFFENGQRCRCSLPPYRFNRGDFVLLRESFDMNQLTHRNKIDSFYEAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4V1</accession>
    <name>A0A4Q9M4V1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0001p0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4V1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4V1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0090"/>
    <dbReference type="OrthoDB" id="2196165at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57817" checksum="CBC7D370D1A4B24C" modified="2019-07-31" version="1">MEKKHSVIEKPTNILMISIENGEDNTFEMNRPFKFVANNSMVTKSRGKFKKQVKDSKSPSLNDPLRISVSKEISKLMKNCILKYRSPSYGDVWSKKSNNDTERQLKHTTEEKVEFSDFPELKNSTNENLKCKTNISYLFNSKNDIQSTILDQEEMKSRRITFGATPDASDYSVTESIFTEPFLKLCLDNDKRVKKYEKIFSSIYVHFWNIPDAINFYSQYYGVVPISFSSLIDTKRIFSPEDFESTRVFYEPWRNLQSQNEAEKITLSNLSVLMDVESIEMPEDDSEECLPLDNLSENSTFEEKVSYFTKMSKFFSINEVKRMQSLASLGILDFIFINTKEVAVGMHTNIIMQTILKTLTQEQIFLVVNQLGYDIGPISATKYGAYVVQIIISLAESKDLQTSIVKYIGANGYRLLKHPIGNYSIQKILRFQPRFVLNLFLSNLTDLCSNELGIRVFRRCSEFFDDYLDEIKKRLETTPNIDSTMMELVMSNFTGVKGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Z4</accession>
    <name>A0A4Q9M4Z4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GATA-binding factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0054p0060</name>
        <name evidence="10" type="ORF">CWI38_0018p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000054">
        <property type="protein sequence ID" value="TBU05062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Z4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4Z4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0054p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0040"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="183"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="418" mass="49699" checksum="4E931608024226F1" modified="2019-07-31" version="1">MTDPKKKEMANNDYINEDVIYIEKDDKRNTRMYSKRADVEDSISTIMNSDVDKNKIRREANKDTERYSEYGTDVDNIESKGGNQRDIANQSLDSRRIANNQFESDHTRGASEALVDKQYYYDDPYGYYKTGNVPAYEYKGYENEYADPSTNKSNIPEPPSHSRYSYYHNMQKLDKGTMDCKRKAKYRVCSNCFTTTTPSWRRSNDGKMLLCNACGLYAKLHGRPRPYSTTPEGKTKALKSGYERDKCRSCGNIDILSWSKSSNGYPICEACAEYQKGPVQNRKTYQDSYPRSMYPETEDYRRHNYYDRVYDYPYQQQYPPYYEQPEKRKSFDSSVSRQSPQNVRPNYSPHQYQNQDISYYQQYPRDNDPRDLPHLYQEKYTDQQNYSEYSRDQYEDQLPPDYDHKSQGRFYKKHQRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5A4</accession>
    <name>A0A4Q9M5A4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein Sec1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0026p0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5A4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5A4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0110"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="535" mass="62584" checksum="17483DAAB28BB6B4" modified="2019-07-31" version="1">MIRDIQKNRIKEFLQVKGLDWKVLILDKKTHEIISPLLKINELRECGVTSHFMLKSNRNRISDTPAIYFVEGNKENVEIIINDIQKGLYVGFYLNFVNSIDRRTLETLAFELSKKGVAFQVKSVFDHFIDFISLQNDLFITNLKFSFKNLQNIETWKGITNSLFGVFLCLNQKPLIIFQKKSDENFVPKNISKMLESKIKNFEKIQSSRKKPLLIIIDRYFDLISPFEHVWNYSALIKDLMEFHLNRVQIEDEKEQNINYDLDPSDFFWRKNQNEFFPLVAEKVEKELLEYKKEVATQNIKENINKMNIHTVLEKAPEMSRRNEIMHSHMKLCLKLVEKIKERNIDDFYKIEKSKYKKNELIDISEKGNEDDILRLAISLIKKEKEEILSALLKKRNINNSCFEFVKNNINLNTEDISNTGTSYTSVVSNVLGNIKKLLPLNTDMPISILVENIWNKFKNGNVDGYDFYNLDGTGLCYDKEISSIIVFCLGGGIYAELKSLKVLENKIQIPIIYGSTEMLNSKEFTEQILELNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5N1</accession>
    <name>A0A4Q9M5N1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small nuclear ribonucleoprotein Sm D3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0011p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5N1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5N1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0020"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="9777" checksum="B5B1F7A27286BDAC" modified="2019-07-31" version="1">MSKEGPLKLLYESTGMIIMIELENNSTLRATVKHVDDYMNVVLKDVIRTDQCGKISNEEVVYVKGNTIKFVVFPPTLEFAPEDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVF6</accession>
    <name>A0A4V2JVF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Forkhead domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0207p0040</name>
        <name evidence="10" type="ORF">CWI38_0173p0040</name>
        <name evidence="9" type="ORF">CWI38_0178p0040</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000207">
        <property type="protein sequence ID" value="TBU03942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000178">
        <property type="protein sequence ID" value="TBU19898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000173">
        <property type="protein sequence ID" value="TBU19922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVF6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0207p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0173p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0178p0040"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="419" mass="48947" checksum="13054B1D34989137" modified="2019-07-31" version="1">MFRENEDKEFDDVAEAMLLLRNNLVNNKYVSRFALLIGDRWEYSVIQMSFTFIEKDVLLYFYYCGGEKMWYVDVIKGNVKINDVEVGNCSLTVKDSFVFDFKGFYFTFYNCVKGKKVQKSYHQLILEAIKSKKDKKMTLSEIYEYFEKIHGFSSKESVTWKNSIRHNLSLNKIFKRVPRKVNEMPGKGMFWTIDSEHLNSLREEKEEEVMNYNVKDSMRKRGEGYFRSEKKIMSLTKEDLIGKITDEFAEKNEFCKNEFGKNELNKNEGNRGIVSNTELFKPVSSCEKIVKIGSYSIRPEKRKAEIQNISKRIKVGYNLNFLRMDVPHIRMIDVEEDVMFFDDKDLHSEGTIYCSDYENELGFNEASFSIGQGSNGKEKRSSSIVSLPDEDLLSDFMLSGCQSFNKHGKGGGNFKRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW64</accession>
    <name>A0A4V2JW64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2503p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002503">
        <property type="protein sequence ID" value="TBU06812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2503p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16555" checksum="DB1249867C405532" modified="2019-07-31" version="1" fragment="single">CSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWP8</accession>
    <name>A0A4V2JWP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras GTPase-activating-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2226p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002226">
        <property type="protein sequence ID" value="TBU08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWP8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2226p0020"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="712" mass="84129" checksum="A220B9D4EC46574F" modified="2019-07-31" version="1" fragment="single">MTISPEQKRSIRTNVHERLESGLPLTSAEMDIEREQNHVYEYMCHFEEAKLWLSAVINKNVQNFESELPKGIILAEVGKILEPEIVKKIFLDETLQYRHTDNINFFLQAVLKQGLPKIFLFEVFDLYERRNIPRVIYCIHALAHFLNKKNIFPKISDLIGKIYFSDEQIQEKNEEINTAGLKLPHFKSIAQKLRDELIISSHLIYFFKYFIYKQTITEHQQLKNNTFNILLHHELLLEKKEKIRNFLVQKIKEFLKLHKITILQSKLKSLLYIKAFNEIFYRKKTLTLFSLRFYIFLLFNTSKTHHSYESEMHKIQTKINKILNENFMHEKYIDELEMRISLLVNNKVTVSNMVMNKPIPQDITLISQDTPHYKNLTTIFYILQTNPKYLIKILYNIQDKDTFIINTIVPLFYFGHGIREECLVNKLIDHILDTYNKEGYSCNGEGYSGDRDNYSGDRVNYNYNKDNGYSNYKDNKDNGYSNYKDNKDNSNNSNYKDNYNNNYNNSNYNTNIYNPYPYTNNNNPNNNPYNNNIYANTPVSLCPSAIICCKILTHFYRVSKESKNHALSISSIISNLSVLEIECDPVNIYKELYNSQPLREIALQDIKVKNIYISRLKTLRGVINSLLNILQRNITNTPFILRYFLKQLFIRKYSFFGIKNMFYEEFILPFIIASDCFDNKYVSKEVRDKCVIISQLMSIIVGMECGLECDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWZ2</accession>
    <name>A0A4V2JWZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor E2F2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2119p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002119">
        <property type="protein sequence ID" value="TBU09762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWZ2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2119p0020"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000458">
        <property type="entry name" value="E2F-like (Mammalian transcription factor)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU09762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26692" checksum="FE3F62A4793C0901" modified="2019-07-31" version="1">MPISSNNINIDTPTSSRNDNSLYILTKKFLNLIQKSPEGTVDLKQASQILGVSKRRIYDITNVLEGLDLLCKYGVNTARWKGGEICNYLQSNFEQESTENENLKIHSDISFDKENTNRLSYYQRKKLENSEDKKNEELLLLQNEEFFLDKKLESLISAFEEMSKCQRNLSNAFVTYKDIDSIPVLKNKLIFAVKTPKDTTFDIPYLENNNHILNLTTHGGGINVYYVSDENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX35</accession>
    <name>A0A4V2JX35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0451p0010</name>
        <name evidence="2" type="ORF">CWI38_1872p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000451">
        <property type="protein sequence ID" value="TBU02575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001872">
        <property type="protein sequence ID" value="TBU10292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0451p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1872p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="55" mass="6361" checksum="905DEAD144B73EBB" modified="2019-07-31" version="1">MKNTEEDFINGSQLNVTEEMKLLEFTVDDCYFSSDESTSTSKYAIDCNESYSWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX90</accession>
    <name>A0A4V2JX90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1490p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001490">
        <property type="protein sequence ID" value="TBU10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1490p0030"/>
    <dbReference type="OrthoDB" id="2193044at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="20111" checksum="2E2F1ABA71AD87D5" modified="2019-07-31" version="1" fragment="single">MFKIEFKFISFRYFYLIWNRPDIFILDKKKNKITLIEVGITSQDSLQKVETKKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLDSGLNAEESWERALMGVIIGSEMHEEPIPPLKEAKREEDGVKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG0</accession>
    <name>A0A4V2JYG0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0005p0190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0190"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="448" mass="51916" checksum="23A021B307DC51E7" modified="2019-07-31" version="1">MTGNDIVDNLVLIIMHARSMKPTSFLTKKELNAFIKFHYPNIYNMTNYNEYLKKAIKTTKNVLFDTKRRSKAVRKEILKMKKHNVFSSPSVQNGCHLDINIKEQNDVEERKMRIRKKIKMYREIKNQGTKSPVKPIDSHRYDSITLSKQSENTYMDIEAALKTKNEILKDFVPSYDSSCKSKKFKTPSICVSDTQNVTVHNNNFPRDGDFSDSLKEIIYSDDPKYISPSVLTNNPPQIPPKYNFPVFYLNDAFTRTTGSPEKIIQDIQLSDNADENNILSETQLSFDQNDPIFSSLLNNQQECIVPNNLQNNQQENIIFDNLQYNQSENIVQNNFQNVQPVDISLDNSLNKHQEGPSNNNVQKFPNVDTLFNNINNEKGYQNHHNFQKIPQNNIAPGDAQNNQIQDSLPVNSDYNIVFNTQSRPTSPKYINLSYGELKERFKRENKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVX1</accession>
    <name>A0A4Q9KVX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative SAS-like centriolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_1851p0010</name>
        <name evidence="10" type="ORF">CWI38_0110p0060</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001851">
        <property type="protein sequence ID" value="TBT98209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KVX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1851p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0060"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="159"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT98209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="376" mass="44683" checksum="0FCC6157E2073884" modified="2019-07-31" version="1">MREPIFTGKVAISCLNEDIPSMMKCDVVRVDDKIEIRLIDTKDIFTFYLCSISAGEFYILKREQDIRVDFEKFVRKLIEMFHMLSKGQLIGVLSRNNNKFMFLEKNEFRNIVRLELKFCKPDENHYKNYLSDLITRLETDNIKLIKDNSFLKETVKSGDREMKERLKYLEEDYSNLQKKIERLYKENGSLNAECNEKNREIEKINSKLIQSEKDKASLEYEIEKKRIQEVKNENLIYKLEELDKNNKTMESEINTANDIIKKLNLELKEVKKNLNDKEGGYVNLKEDINKYKKVSEDLNKKIKILEEKLKNSKEEIKNKENKIKNLELERNNLIKKLENAQSVYNHFYKKNVETDSPNDSDYESVMSSIRPESPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXY7</accession>
    <name>A0A4Q9KXY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1327p0010</name>
        <name evidence="2" type="ORF">CWI38_0040p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001327">
        <property type="protein sequence ID" value="TBT99484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1327p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="281" mass="33387" checksum="E5DED55782893054" modified="2019-07-31" version="1">MQFSNLIWNACIFQYAYLINCAAEQEELLLEHMESGNNHIDDHKYKIYSSIRNFSEVILKKRLHQHEHFIDKYHIHCKINLNQIDTNSESIRITMKDQTDYNRNYVLTWKLDPQYNMSDFIAEMNHSIFICNEDIEAFEKTNHTILKMKFEDDIIYGKIGKIESNVVFSLYLVQNLATLKNLRTFNRIIGGSSQKSNYKSFVLILNEKINSYDRFVIFTEYFKDDGKNFDSGYISVMISQKYSENILSDTVCYLKNYKDCSIFAKLKLYFLNYKNRLILAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1M5</accession>
    <name>A0A4Q9L1M5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0864p0030</name>
        <name evidence="2" type="ORF">CWI38_0160p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000864">
        <property type="protein sequence ID" value="TBU00905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000160">
        <property type="protein sequence ID" value="TBU19976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1M5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0864p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0160p0020"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="119" mass="14018" checksum="1E97AF275B6FEDA9" modified="2019-07-31" version="1">MNSNINSTLETEYKILSKVIYKSKNRHKNTFLFRKLNNLKRFIKKFKETPNTKDKYIIQVLSQDIYLLGSSNIEIGHFISLSLVCMGLAARFKYLVETFDFSKINTTEIDSIFENIFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L391</accession>
    <name>A0A4Q9L391_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0696p0050</name>
        <name evidence="4" type="ORF">CWI38_0023p0060</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000696">
        <property type="protein sequence ID" value="TBU01495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L391"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0696p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="159" mass="15935" checksum="284150BE7DE3D5B3" modified="2019-07-31" version="1">MFSNFRISDMLSTVGIFGILSIFAIFGGLSIFGVSCTQVSMSSQSSGSGGKSTPDSQGSNKDHDTNHTGGNDTGMTSPGMTFPGMTMPGMTFPGMSFPDIKVPEGGSGGSGGSGMHSSSSSSYNGPGGNTHTVSVSKPGGGAKTVTVRSDGNKTEVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8U5</accession>
    <name>A0A4Q9L8U5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="2">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0177p0020</name>
        <name evidence="6" type="ORF">CWI38_0913p0030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="2"/>
    <dbReference type="EMBL" id="PITJ01000177">
        <property type="protein sequence ID" value="TBU04149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000913">
        <property type="protein sequence ID" value="TBU12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8U5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8U5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0177p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0913p0030"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="472" mass="52599" checksum="12DB44F100EFE7C9" modified="2019-07-31" version="1">MNTKEYLNFLKDSPTPYHATQNIKKILLTHNFKELKSLPTDLQPGKYFLIQHLTLLIAFIVPPKTPTSIKIVATHNDSPVLKLKPNHQYTESNIFLSSLQPYGGGLWHTWFDRPLGVAAFFYIPSLAIHLDNTGIYKNGFQYDKETHLNAITDLKSKQDNSLSRQNSTLEDSKVENNIRQSTNQNNSSILNYISKKYNLKEEILSHDLSLFDLSIPQTGGVSNNFIFSARQDNLFSTFCAIKAITDISDTSDITDTSDTSDTSNTSDVSNASNTITSDVSNTSNTSNTITSNTSNTSLNIVAVFDNEEIGSTTVTGARSDFFIKTIKNIICILKINLQKVYTNSIIVSTDVAHCRHPNYTDKSEKNHSVLLGEGVVIKYSNRYATDIMSSAVMKRLFLKNKIKYQEFVLKNNMVGGSTIGPMLAFGLGIRGVDIGAPLLGMHSVSEVSCVYDLDGNILLFKSLFEFNKDLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LB27</accession>
    <name>A0A4Q9LB27_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fcf1-like rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0065p0050</name>
        <name evidence="10" type="ORF">CWI38_0706p0060</name>
        <name evidence="9" type="ORF">CWI38_0916p0020</name>
        <name evidence="8" type="ORF">CWI38_1677p0030</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000065">
        <property type="protein sequence ID" value="TBU04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001677">
        <property type="protein sequence ID" value="TBU10569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000916">
        <property type="protein sequence ID" value="TBU12057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000706">
        <property type="protein sequence ID" value="TBU12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LB27"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LB27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0065p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0706p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0916p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1677p0030"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000039">
        <property type="entry name" value="rRNA-processing protein FCF1 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="175" mass="20585" checksum="9EC6B3430AEEE4D9" modified="2019-07-31" version="1">MSKSKFSGRKRLLNYKPQQIQPIKKQMHSLQPLHTYFLVNHSLKPPYSILIDTNFINHTIRRKLDLHTEMLRCLYSNYNLYVTECVIAELEKLGRPYRVALNILKNPKYIHLTCDHKGTYVDDCIVERVTSHRCYIVATCDTELKQRIRKIPSVPIMYVKGMHYDVEGLPNGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBD3</accession>
    <name>A0A4Q9LBD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0057p0050</name>
        <name evidence="9" type="ORF">CWI38_0106p0010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000057">
        <property type="protein sequence ID" value="TBU05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0057p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0010"/>
    <dbReference type="OrthoDB" id="2194933at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="160" mass="18811" checksum="ACE8EF8D0E9C7066" modified="2019-07-31" version="1">MEWITEKEAETLIALLKIRRENRIKYIGNNGYKYKSRRQLAMLNRIYNITNYPSTDTRNDIAVLLDIPQRSVQIWFQNTRQSMKDPKFVSSTDQKMKSILSGFNIISSKILKSTSEFSFKFHDSYATMNYEGNSFDISAFNLIKVYQEVQSEDYSEESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBF6</accession>
    <name>A0A4Q9LBF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0043p0020</name>
        <name evidence="3" type="ORF">CWI38_0050p0040</name>
        <name evidence="2" type="ORF">CWI38_0893p0030</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000043">
        <property type="protein sequence ID" value="TBU05157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000893">
        <property type="protein sequence ID" value="TBU12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0043p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0893p0030"/>
    <dbReference type="OrthoDB" id="2186928at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="175" mass="20892" checksum="AE734E230906723F" modified="2019-07-31" version="1">MVEEKNESNEEFFNTIDLFNECGLDKKKTLISQKSEPKEAINFDQNEFISNSNKEAKYQPCDSWMDFVYSYKILSSQQKKGMDEFFSQDSSLWTKKNLRDLSHTLKIPYRTIIETASKKLVNKKDLIVDYVTLYKEELSELDICISRSWNSYVRMARHFYDQIKHYKSKNKEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDH7</accession>
    <name>A0A4Q9LDH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2669p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002669">
        <property type="protein sequence ID" value="TBU05968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2669p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="37005" checksum="BF59CD151AEC8052" modified="2019-07-31" version="1">MYLEIPYEIGENDEVKECFDKLELDIEDQRKEKVIPITSFCYNKIKEYTNVKFHPFILYFTTYICYFVYRDMQFDVKKYRPELLFNLITFGRFVEAYKTDEDIKSIIKDISFKLARYDAQRESENISERCNQIHNASEEKCNKICSNMKNSLNQDNKIDIFVLENTKFIKGYSSEASKSKISINLANATVENYFGFFLIINQRFFKGKEYRVDITRKSAINKSTISFLELKIMLEKTTGCINLFSAMIDFKSYKKIAENISEPIFRKILKVKDGFEKIYEFSGKKIPSTVRTKDSNVSLEFIENIVKRKEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF76</accession>
    <name>A0A4Q9LF76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helitron-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2532p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002532">
        <property type="protein sequence ID" value="TBU06647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF76"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LF76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2532p0010"/>
    <dbReference type="OrthoDB" id="2507248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="104"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="348" mass="40648" checksum="371018D805BE7450" modified="2019-07-31" version="1">MMYEVEEAQKYLKPNIETQIQMAIVQNRNTDPRRYNIQRCNEVAMVFLGKGGETLIDRDLLVHIWQEDTLIPKTRRIDYRHRNPDALSYPLLFLYGEQTWGVNAHKNFIVDAYCKAEYIANQDSKEGIPVGKRVILPSKFSGSPRNMQQKYQDAMGIVMKYGKPDLFITTTFIPNNAEISENIDANEKRENTPDLVDRVFRQKLKALMTDIRKNIIFGKVNVYCCPRDSALLEKIVSAEISDKNTHPRLFSIITKNMIHGTCVFSFKSDGYPLYHRRKNDPVKIRKNHVDNSWDVPYRFDRANISFRFDKIKNHKDSKSVSPHEAVWRIFKLSTHEQSHTVERLAVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFT0</accession>
    <name>A0A4Q9LFT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2487p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002487">
        <property type="protein sequence ID" value="TBU06908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFT0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2487p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="89278" checksum="C17B9C7F70EAEDFF" modified="2019-07-31" version="1" fragment="single">SNTLICIAITLSNILNIKSTFIEEYMVEGVSNKNKEYKGVSSIISKFEGISVVECDSIKGISNYKGDNDSIKGISNYKGDNDSTNEQQGDNTNTNGQQGVSNKDCNYHPFSKMTSKQHPVNNLSSKQHPVNNLSNEQHPFSNMTNKQHPVNNNTTNNNPFILYLNNNSIIYLNNTFIDSLGNNKHFILMSCKSNNYSEYSNEYKGYSEYNKYSDNSKYNQYKSNNKYKSNKYVNVFIRMYKNKSLSNKDINIISKNKRLLNYYIQRYMGSDYRGVNKGYYNYRGVSKEYDNYRGVSKEYYNYRGVNKEYDNYRGVNNRPYEQQGVNNSSSKQHPLNTTTSKQHPLSNNTNEQHPLNTTTSKQHPLSNSTDNYHPVINSTNKQHPLNNLSNVQHPLNNNNYTPLTFTSDSNAKVSLITFNNTPININYLSNYTLSFITYKYLLNINLIRKDKLAFPNIKYKIHNIYNNRYNIYYNSIVIASKEYSDMVINNYNIIYSDGMIGGVSDSSMIGGVSDSSIGIKGVSDSSTNIKGVNNSSGNIKGVNNSGSNIKGVNNSTSKQQGVDNSTNKQQGVNNSGSNIKGVNNSGTNIKGVNNSTNNIKGVDNSGSNIKGVNISTNKQHPLDFSDEHVFEILFFPLYDCNILNILIFIYGIDRIRNIGILMLFNKYKYKYKDIMRCVRSVLEDKREILMYCYNFKEFIGREVSVSMFREGYKYEVCKWYKDSVWDDEGVWDIGSDRMGKHGLDKRVGNMAPLNNRIGNMGPLNNSIGNKTHLGNNRGNSTPLGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGV4</accession>
    <name>A0A4Q9LGV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2585p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002585">
        <property type="protein sequence ID" value="TBU06401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2585p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020285107" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9915" checksum="E1A89C1E92F7AC53" modified="2019-07-31" version="1">MYLKNVFFYICFLTFLSLQFDACLKLKKDVIYNDIFEPDYEFKECNTIILVYKNVYKLNVFVNISKEKEKYAEDCILYEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHB5</accession>
    <name>A0A4Q9LHB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2590p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002590">
        <property type="protein sequence ID" value="TBU06370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2590p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6810" checksum="3B7FF8184BF9D360" modified="2019-07-31" version="1">MSFVPVISNAILCINNTLIYNRYMLFVFYFYPIISGLFRIYSSFYCSNKISIFIWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHF3</accession>
    <name>A0A4Q9LHF3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_2583p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="PITK01002583">
        <property type="protein sequence ID" value="TBU06410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHF3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2583p0010"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU06410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="26573" checksum="80BD05ECC28B9295" modified="2019-07-31" version="1" fragment="single">MSKIWIDGCFDIFHYGHANALRKAKSMGTYLIAGVHSTKEISLNKGLPVMTDEERYEVVRACRYVDEIIENAPFVTQLSVIQSHNCHIVVHGNDPIVDENGNDCYQEVKKKGMFREFERTLGISTTEIVGRMLLKQKPTPELCTCNRCDTTTNTSNISLSPNISNSNISSPYAQFHDALLHLFEIPKKERKGTVVYVAGTFDLYHAGHTSLLREAKKLGDFLVVGIYRKGMNKSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL90</accession>
    <name>A0A4Q9LL90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2215p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002215">
        <property type="protein sequence ID" value="TBU08837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2215p0020"/>
    <dbReference type="OrthoDB" id="10604946at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13611" checksum="B0AEF18B9ACC0779" modified="2019-07-31" version="1">MRRPVICDDEKKKAVQLKNRLSARKSVENRQKKIEMLEKLNESLLQTNNELKERLARLEILIYGHLQYCPSVNNPPKSSSGIEPVSTLLVANTNSKVCFFTPKHNATCEGYWQPFVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM26</accession>
    <name>A0A4Q9LM26_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2154p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002154">
        <property type="protein sequence ID" value="TBU09398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2154p0020"/>
    <dbReference type="OrthoDB" id="2191533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28537" checksum="A64F014E178E5194" modified="2019-07-31" version="1">MSAENILAGNVLRLIIDNHSRDTCTSKKDIKHMFKISTNDLISTLNNIENKLNNICMKLVGIYKDFPTEDLNLAEKFFIVKNISDKFNENLQNNSESSKFTNKNENKIHTENNNWNQNNSESNKFTNKNENKIHTEDNNWNQNNKICDSNNNERNDNINNQYNKDFEILVIILGVLYLEGGRCSYRRMVVVLKDTINFEKFISIFRKKGYLKVYKEDGEVMIEYGWRFHLEFPSFSIDEDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LME7</accession>
    <name>A0A4Q9LME7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2240p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002240">
        <property type="protein sequence ID" value="TBU08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LME7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2240p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="19258" checksum="C91E703E121F00FF" modified="2019-07-31" version="1">MLRIHNVHFFEYNDTDIKFIIFDIEKFPLNLKEEEYIENKVNDTNKKENDKIKQSEIKKFEFFLNTFYLPSFNLCLNTFYSNIYIMESLKVKYDRALVKIIESLLFSLKNILNLETELLKEELLNSLNENLLSDRMSLLIFDIFNKFSFGNQALSKKALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNR6</accession>
    <name>A0A4Q9LNR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2060p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002060">
        <property type="protein sequence ID" value="TBU10058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNR6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2060p0010"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="61"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="37051" checksum="911F8969384731B8" modified="2019-07-31" version="1" fragment="single">GTTNLHPLINSTNTQHPVSSSTDEQHPVSNTPYKQHPFSDNENSLLNIKPFNYYDSSIPNNVILVHGFNGSSYTSYIRNLALHLSNENFRVFGFNARGVTNLLESTTFFHIGWTEDLHVLVNYIIDNYTGYISIIGFSLGGAWTVKISSEITNPRFKCGVAVSVPLDFIKIKEYMLKPVQRKLYNRMLTNKFKQYFIKNWKVFEKEKFKMKDLLKCQTIQDIDLYFTSKVFKFKDLESYYEDFSGKKFIPKIKIPFMILNSVDDPLIPEFSIPKKKCEENENIFLVLFSKGGHVGFLGNNFYKTYTEEVVVEFLKAVHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPY1</accession>
    <name>A0A4Q9LPY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PrP8 U6-snRNA-interacting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1778p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001778">
        <property type="protein sequence ID" value="TBU10414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LPY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1778p0010"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding" evidence="2">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PRP8" evidence="3">
        <location>
            <begin position="966"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1701" mass="188309" checksum="F30E287256F030E4" modified="2019-07-31" version="1" fragment="single">PLNNTNRYPLSNTTNTYHPLNNTTNTYHPLNSTTNTYHPLTTSLTTPNLLKFRGKLSHLLNKGLPRINTIYNKDKDIRCYDKGYRIRGIYKKYNCKYDYLYFTDIRHDGKIYDVSSYSSECVIKLGGYKEIYKHTLYSCIFGRDDSREVGGDSNRGSVLGGVSNRGSMLEGVSNRGSEVEGVSNSVDEVGGDSNKDLLEGVNNSRDILEGVSNSVDNYNPVSNTTSNYHPVSSITSNYNPVNSSTSNYNPVSSSTSNYHPVSNCTSNYHPTTTTTNHINNHTTTPHTTIPLISLHTLSAFEESMKYKKLTLAQQQGINILPNKRFIFWWSPTLNRSNVYIGYCIELEQTEIKMYGKLNTLKTCYLQVFRNSLWSKIQRSITREVSRCMMEGCDMVGGDVEGGDMLEDMVGYNMVGGDMLEGYSNSNSGFSYKSNSNSNTSNNSVSYNSNSNTSNSNNPSYTSNNTTNNNPTNNNPSITIIDNDSCIVVKRVLKDLEIGYYDTIGNSNKDSVSSRDGVKDGVNDGVNSSSVSNKDYKDYKDINDIKDSVMNNPNIQPTPNHNPIDTSSSDTVTSDNLIDTNPNPNINTANPNPNIIPNPINTITCNTLLIKVFLLWGDYDNSNIRNYTYYKYKTLENSGIGGSSVGGSRIGGSKIGGRDKGNISNTNNTYTNTYTTTPNNTNNTPNNTNNTLCLVLAVDLLYNTFSSYGYTNIYIKNILKNIKTIINNNRCIRIMKERIKKVLNIGLEVEEGVKGVNNIEIYKCDVIVDDEGVNRKGKGYVVIYIVGKGVLYVMWVNGCYEGDIGEYIARGVIGIIEREYSMLGGDSEGMDVSIEGNIKGVSEGMGSGKLGGVSRLDGNIKGVSEGMGEGGMYGNIKGVSRLDGVSNSTNTLHPVSNSTNTLHPVSNSTNTLHPVSNSTITLHPVSNTNPIPKPNPNPNPIYTNEQHPVSNTNPNPNPNPNSNNILICSLRKSFMEYLSVICMEKERLEITGCYNNINIPFKIFIKEYLKEYLKGVNKEGIWKCNLYEGWGVISKYTSFCRLMVILRGMHVNYKESKRVMYSGGRGEGDRDSGDRDSGRGEGDRDSGDMDSGRGEGDRDSSDRDSGRGEGDRDMLVGSNKDISSNRGNKGIVLPKPNPLFNSSITNPLFNSSITNPLSNSSITNTLSTNPLSNSSITNTLSTNPLSTSSITNTLSTNTLSTSSITNTLSTNPLSNSSITNTLSTNLNTNPNPNPNTTPYPLSTNITYVNNIFPILSDSEWIKVEKELKDIIINDYSVKNRIESSKLTQGEIRDIIFGIELIKREEIMKCGDMEMGGGIMEGGDKSMEEGGYVGGDIEGGDLVVRINNPFIETNPLDNPLDKTNVCINRNDFNPFTETNPNTNPNICINRNDFNPLDNTNNNISTNTLNTLYTNTLHTHNTNTLYTTNILNTLYTNTLYTVLRLCNIYNNYRHVISKELLISFIRMTDLTGVFYGVLIDNKYGRGIGVLPQYYNNKRLYTVKSINLKGIEGVIGVKGVVFFNGSLEDIRGVVFKVGGGVRSVWVVNVMKDRIECYESEGSNKGVECYESEGSNKGVECYESEGSNKGVECYESEESNKGVECYESEESNKGVEGGGLEGVSDSRGMLEGVSNGGSNIKGVSYSIDNTNKQHPVNNIPYEQHPVNLKGYFLVCEMWNFYFKREWFDEDMSYSLKIGYPLNFYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG8</accession>
    <name>A0A4Q9LQG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1870p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001870">
        <property type="protein sequence ID" value="TBU10296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1870p0010"/>
    <dbReference type="OrthoDB" id="2196318at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="27290" checksum="3CF6E032CB75853A" modified="2019-07-31" version="1">MPCPPRPIPCPPNPCYPNRHKRHHKKHHRKHDSCSSSSSSSSSDSDCKPCHPKKSHCPSLSKKHCKVKKGPFKCKGKGDVTRLEVDKMFCSKTFIYNPRELFCGDKIKVREIVSKNTNVCKDILLQPLLFGKHREGKLSYPALLRFPCFLIELIKALCERCKIYRPCLYIDKCNRLYVLIHKKLYCIKFMKNVQYFRPETAKCFKLVPISRRKTCKLIQSGLYGIVFDPNAPQCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK3</accession>
    <name>A0A4Q9LQK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1841p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001841">
        <property type="protein sequence ID" value="TBU10336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1841p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="38783" checksum="5A6C8364AC01D661" modified="2019-07-31" version="1">MAIKGQSLDGQCFEEELELCQKLSHPNIIHVLFSFKMNKSGYIAFEYFPRTLFSILNEEKICLRDLKIIFKQLLDALLYLEGEGVIHNDIKLDNVVVDSDLNAKLIDFGLACYVNRPRRIFSPQNPVSEERKNLFPYFSPEVLKGLDQGFKSDIYSWGFMLRNAASGILFINPGDFHTDVTDISDHALQVDLDARPSVDELIFHPFFDEIYEFLFCFNDYEDIKITSGDIYIEKIGSKIFLKGNEFEIALYCGCDYEKTDESVTRLLNMGIHSEKCTVCRTGLRVSKYARFKFESFYTYNRILNNRIHPFICISLDNKFNNSLSGSIITKNKREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ8</accession>
    <name>A0A4Q9LQQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1683p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001683">
        <property type="protein sequence ID" value="TBU10557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1683p0020"/>
    <dbReference type="OrthoDB" id="2189352at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="37670" checksum="8EF44A35E530DB30" modified="2019-07-31" version="1" fragment="single">KILEKGLKNEFISNSIIKIVYDLLTNEIHVDGLIKIFVNKIGGKKIVSHFVCYKLTELVKMNKNKENRNKILNEIYEYFSRDTVLKARVKILKIIRNLKFDEQEGIIIRKILNIIFSEISTYKTEKSELLSCYINMGIEIYEKIEKDFENSDLEDDFILEISLSNCNSIKNLIHILYKTKSKKLGEYFTMVFKNNIINNYEKVPEILNILLNFLLNENDIKIRKKVMINSLKYIVMNGDIRMILSILIILAVIVEKFGNEILYDNFAIQVLSRHYYKPIQYLFCKIMNTERIEIFDPYDEFSLKNTENIIFSINKVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX2</accession>
    <name>A0A4Q9LQX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1491p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001491">
        <property type="protein sequence ID" value="TBU10888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1491p0010"/>
    <dbReference type="OrthoDB" id="2196365at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18335" checksum="0BCFFB791778032A" modified="2019-07-31" version="1" fragment="single">MKLFGTKKISERKLFRILVWLSITTRFFFITFPFSLIQEEAYFIKLARGLIERQFKYDLQPPLGKLIISFLLFWGKSNFSVLSEIGMPTVFHKASYVLLRGVSVILSIFVILMTYKILLRILEPWKAFLVSLLVLFENLYQMHFKFITADPYSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR41</accession>
    <name>A0A4Q9LR41_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1693p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001693">
        <property type="protein sequence ID" value="TBU10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1693p0010"/>
    <dbReference type="OrthoDB" id="2196255at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29254" checksum="61837CF0E6CD4D0F" modified="2019-07-31" version="1">MPSITFSEDEKILLLKYCRMQIIKICRQFSLPYTVHSTSSHFIRNIFYRSDISEYSIDNLITAAIFLGCKSEDINIELSLLLKNNVGLNESLIFQYELLLAQYSDYRFSVSCPYLRMLGCIILLQEKDRVVVKRGQIDINNVSIINTEIKNVENNSFDYEDVLKNIFFIEDINIFWRKSVINLDKIIIMSGFEKITATELALSSLDLPVKYLHSLLEKTDTKRIEEIRNSYLQLNIPDSNVISLLKNKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR73</accession>
    <name>A0A4Q9LR73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1670p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001670">
        <property type="protein sequence ID" value="TBU10576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1670p0010"/>
    <dbReference type="OrthoDB" id="2188983at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="285" mass="34054" checksum="140A61D37E71E35B" modified="2019-07-31" version="1">MRSVEHCDMFKTFESPKDFIKMYIKVFDMQKDTPYKVFLNDTPYYKDFHSLFIDDLFSKVNSSTNQKKIRKYFLEIENILLSMKDREFYDINFYKDCMNIYLNAVTYLIDNSESEIMEYKDKEVICSERLVDSCVNLFVFTSKNICLYNFFLRNLCTDLNASFTDIVTFFEKIKNIKKIIFEINESIRSVEMSKYKEKAELMAKINISDLLISDIRVLQHSFDTFFQELIFLIQKYLLTLPMEEAYLKSMNFTSEMVLSNLTNEELAENMKIFSSKLLIQEESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR77</accession>
    <name>A0A4Q9LR77_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1439p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001439">
        <property type="protein sequence ID" value="TBU10998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1439p0010"/>
    <dbReference type="OrthoDB" id="2191697at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="92996" checksum="C83C47B816A011CA" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEFTNTITIETLFHLIYILFSFKLISNVSGEKNIFKFQTNEDYEILFFYVKKDKNYAEYVCNEDYELKLLPDFNVDLDVDKHPFFIYGTENFITFEVFDHILSLNTSDKEYKKGIIECRYDLSYFLRLTKDISEASNELNGYQFKCMLMTLKNLKVLTLGFFNNLMITCEFYYGNLILSEGHGNYFDVSLLNNNIPYKNLLINSYKVFRSLENILKSSCILNTLRLLFNELNIKSLILNDFLCDEIISDDFAPIILSMFDFYSVKISNFRIQNSLEFLYCILIGIKKDIEILELVNIKSYRLNLNFFLKERKPRVLVLCEVNLIEYSSLVDDFPDFYEKLEFIDFRFVYLNSHWWNDFLQKANLNKIILYFDNSKSEKNFSDEFTKLKSHKNNILYLELIFNCYKITTDFCNSLLFFKNLKTLKLDRYIIDEDTGSYFYKAIECMKELEYLALCQLADITKPFDFLLNKFKIKSLFLQNISVDNDIILIQFLKKYLSISSCNSRTGYLSKLNSKCSLSLKRLSYRYGTIDFNDINKIGELKVLEELKIYGCKFLNYTFKDFINSCKFFKSLKNLKFWVLDMKNDDLLNLKRFRKLKKLSFRFTEFELLNIKNCLLSLSISQLQNLASNDVRNYKIFCRYLRESNLEDQYALKDSSNILGKLCIVFPSEKSITAGDNNTLHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD9</accession>
    <name>A0A4Q9LRD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1359p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001359">
        <property type="protein sequence ID" value="TBU11143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1359p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1876"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1876"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1888"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1909"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2057" mass="228110" checksum="78491D0D0ADAF342" modified="2019-07-31" version="1" fragment="single">VNTPLVEGCVNNTPLTDNTGNNTPLTDSTGNNTPLTDSTGNNTPLTDSTGYNTPLTDSTGYNTPLTDSTGNNTPLVDSDVNNTNNHTNNHTNNHTNTTTTLISNTFTWINNTLYLRTVINIRNNPNIIFTSKNFNIKIYINYFIFTITLRKGIIDLNKGLIYLNTKIERNTTTVKYPLVNINTGYTSRITYEYVTGVNNKYSDYRGVNNSRDDYKGVNNTINSNSEQQGVNYSSSEQQGVNNTINSTNEQQGVNNTINSTNEQQGVNNTTTNTFIDILSQLLDYCNLKLIGIEDVNNLIFKLCTDTHINNKLKEIFNFNKNVPNIIFTVNIPSLRFSIEGTEGVICSSGGKVENRVGDVIICNSSNGGVNDRDGLEGVNNTTSNYKDIKGVSNKDRLEGVNNTTNKQQGVSNSSNEQQSVNNTTNKQQGVSNSTSKQQGVSNSTSKQQGVNQSTNKQNPVNTTTNTYHPLNTTTNKQNPLNTTTTNSNKKRGVIYDTTDYDSTNTISISKNRIKRLKKRIIRNKKNKNRSKYINRDSSKYISRDSSMYNNNEVYNTTDNNTNTNTHNNTANTSTLAVINTDPLKLLIGCTNNRYWINRKCVMGVIRINIIDYSKLKGFNYISINSLSNSSSVSKCIEVLFKNMYILVKGVNDKDVLEGVSNSSYEQQGVSNSSSNYKGVNNSSNEQQGVSNKDSNYKGVSNSTDNQQGVSNKDSNYKGVSNSSNKQQGVSNSSSNYKGVNTSTNKQHPSTSTTTTTLNNNVCNDCNNNIYKTEYFITKESDLSTNIKTCYKCNNIILNNCIPYSDRIPMCRCYSSDKGIEYNTVYDIIGYNSMLGGDSNSNSSRDSKCVSNGNNPFTTNSTTNHTTNGTTNNTTNHTTNNDTNNTTTNHTTNNNNNTYDYSGVSLKVRGHRTVKGYSLINIGITLPISNTSDIKGINIEESISNCVSKENSVSKEYEGYKGDNTSSSKQQGDNTSSSKQQGVSNSIHEQQGDNTSTNQQQGVSKSIDEQQGVSNSIDEQQGDSNSIYKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGVNTTTNKQQGINTTTNKQQGINTTTNKQQGVNTSSSKQQGVNTSSSKQQGYINTTNTYHPLSDTTTNTPTNNTPISTRGLRISWSNIFLVMKYEGKVLGKVFFKKNYFDINIFKGRFEKYKECNRYTNSSTNTYTNTPNNNTPNNNTPNNNTPNNNTPNNNTPNNNTPNNNTPILHYKLVLIYNELLFDKGIDKIYLKYNNNTINISNITYIINNILIKKDSFTFKRFIEKMCFNNYIFKKYISRCDDGGGSDGGDIRGEGSSRDSSNTKDIKDSNRGEDIKGKDNKGKDIKGKDNNNHTTNNNNHTTNNNNHTNNNTNNTNRVRVGLRDKHVDVYIDSAYMCNDKCICVGKCICGNEGEDRVEGEDRGDGGGGDDSKGGSSKDSSSKGDGSKDNKGDGSKGDGSKSNTKSNNNDNTKDINNTNNTKDNNNTNTHTNTHTNNTNDSLVSRYCVKGNLMVYDPLLLKKISYYILKGLNYNNNIIINNRVLIDIDLRGVLNYSILSNNDNYFMIFVNKFIVREEIVMYCKCCGCLECRVLDVERCGCGVGGGVGGGVDSGVDGSVGDSSRYGDKYYSDKYYSNKGSNNNNILNNTKDNNNNNNILNNNDNNILNTKDNNILNTPTINTNTPFVISSIPCYFPLNIKYSLGILDCYNYNKSTFNIQMVIPGILRVLSGSEWVLRVYKNKNSSNMSLICFESNKSVRIKIRSGKKYVILCRDGCVDVVGVFGIDKCYDSFMIPIWINNKDIDLNSSGGGCRGSGSGGGSSRGSSSRGSSSREGGKSSNSNKDNSKSNKDNTKSNKDNSKDNTKDNNKPNTKDNNKPNNKPNNKPNTNTNNNKPYNKDNYFEFRGYEILVCNSEGVIVYRRGIYKIIYLIIVYMLNLMKYEKYFIGKNFFNSLFTVFGNIKMCCDVEDDVFWEDVFEGVKEWMEGIKERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI2</accession>
    <name>A0A4Q9LRI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1363p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001363">
        <property type="protein sequence ID" value="TBU11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1363p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="340" mass="41129" checksum="05CE93514D688691" modified="2019-07-31" version="1">MISDSKNELENFLSYNFYNYINGINLRLCRRSYILFDFEKIFNFDYITRLKLDFKRLKYKCLKNYKFLESFIFLNKLYILNVNLTIELLVILLRSEKLKFILFKSFEFNEKINSNDLEITNKSVIRIEFLDLKNFLNAHFFYFINKFMSLEHLLLNLIFISNTKRKNFGFEDKLINLNIYNLEKCVSLPRLSHLEYKNKVECKNSSLYSILYVFTFFFDLYSIEKLVYDSEFLYQEDLNIIANLKSLTNLKLCIYKNDLKDNILQQILQSNIKETVFKLHIYVYQFTNLELISILYFRNLKFLKIAAIFTEESSEKYEEILRGINLIEFESYLGINFNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN6</accession>
    <name>A0A4Q9LRN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1326p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001326">
        <property type="protein sequence ID" value="TBU11198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1326p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="50387" checksum="F5EDAFFD25B6277A" modified="2019-07-31" version="1">MHMRISYNDITADNSEFYFDKIKDYIEKELHPFLRHFTTLNCCIFYNDCSEEYLKAYQPELLFNLICFEKFVEMYKENEEYKDIVQKIFKDFLLDKINRFSYKNLDYLIPSYEALTPDISRSFNKRDETDLESQFWPLVFPVNLNESAKNIIETATILSTNMNNVFNDQQYKMVLKFISEKIVAKVLKNQNGFDEIFELDKNISNFQNKPEDPNFPHVFIELLCNETDVIFIKTLYEFLIEKTKEEYHNYISAVLCLKALCLGEEILNKKNISRIIIEFLFLVDVLKTESRKNENIEILKKYRKERIDSFKQIFDQKKIDYVKKEDGNYLNCNKVPKTTVLIEIYCFVEFFSNDSFKTFLDNQINEKMTKEKNKIFANNSKIKESYFKYIFENELSTLTSEDRKLRFCPPESANPDPESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV0</accession>
    <name>A0A4Q9LRV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0112p0010</name>
        <name evidence="3" type="ORF">CWI38_1787p0010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001787">
        <property type="protein sequence ID" value="TBU10401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000112">
        <property type="protein sequence ID" value="TBU20206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0112p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1787p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="43678" checksum="2DB2CC595450E363" modified="2019-07-31" version="1">MDEITIETIVKRGNLAKTEEVIQTAGDSENSTMKEEFRKSDGSEAEQVAQIILDSNEEENIAKIKNNFSKSGINIVGSVDSRGNQDARDNENIEDITSDVDVCALKSQSSSETIPTSFSGGLKDKTSRQASSREIDTYSIVIRENMAGMGELSSNYSPLGEYMPVAQVYQSGNTLPKQKQVFSQRSYFTMSECGNFSVSALDLNYLPWQNNDKYSTIGFSDLPLVEFRRGKYEGNWNLTFSQELSPRSELEYESRMNLSNFAEALQVFTPDLEERDADESVAFNSQIYLKSSKYIYLDIYLIFFTSCLLCGISISNYNHLNDLFLATSLLAILFLIIFSCNILVTESNLKNKDKIFHFINSITIFTTIAIILTFTLGVFQKFWLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH8</accession>
    <name>A0A4Q9LSH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1310p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001310">
        <property type="protein sequence ID" value="TBU11237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1310p0030"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="6">
        <location>
            <begin position="190"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="575" mass="64331" checksum="7CB31EAE2BD9D5AA" modified="2019-07-31" version="1">MSYDRSHAETSTEEKTVSIFSDTFLIETSLLVNALDNIEARLYVDRRCITNKIPLFESGTLGTKESYSSSRDQPDKSIPSCSIQWALSEFKSNFEEKIISICEYIKCGGDILEGDSMDRGINYRGVNYRDSKLEGNSNGNIELDPVNNSINNLHPVNTIPTTSTPYITNATTNNTIPTHDNLSTESVAIETFPVGHVTREGQPFWVPLKRPPLPFIFNKDDCVHVLFVQSYCRVICNVYEIKGLEGNGDGVSYKEVKDIIRDGIYDKSMLEGVNDNGSKLEGVSEKGSNIKGVSNSTNKQHPFDNCSIKQHPLNKSSNEQRPFNHQPNTLHTNIPSYNNTNNIITLHPVTLKKDNDSNGHIDFIYACANLKAHNYKIKEVSKLTVKGIAGRIIPAIATTTSVISGLCVLEMIGYFLYGLSFIRCKSVIEAEKMECGMVRCDSREGGVNNRDRLEGVSDSNGLEGVSNSNGLEGVNTSTSKQHPVNTYSDILHPVNTNSTTFTLWNTFVPGDCKLSEILKYFNREWNVDISMKEGEGVIICVFECLFDIDNFPEVVVDFRREKERFRIGVRVISDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI3</accession>
    <name>A0A4Q9LSI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1713p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001713">
        <property type="protein sequence ID" value="TBU10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1713p0010"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="31980" checksum="A5860BEDC5343E5E" modified="2019-07-31" version="1">MNNVGVIYIIPDTNVFLSNLDILKNIVKTKSKLKVCILVSSVILDELDNKKKRLVKAREAIRFIEILTKQKKLMIHNEFGEENINIQYTSETKYLEDQSNNLKGGNNDEKILAVALHYHRCVVLTNDKVLNLKAEKASINCILIGEMTNDEFILKFTNFFEKKPLEDTYLNLREIIEEKVKNLIMPLVLNLVYEKIGSAMKFYFPEDSEQINLSLLLDVIVKHFHLFSDFLPKFSFEKFKKIRNKHKLCSEIEFERYMKEILVLFRITDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK3</accession>
    <name>A0A4Q9LSK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1715p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001715">
        <property type="protein sequence ID" value="TBU10500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1715p0010"/>
    <dbReference type="OrthoDB" id="10635423at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="20981" checksum="65DB3BD0ACB01A6F" modified="2019-07-31" version="1">MLGLYFIEIINVSETVLLLFFYFNIYTSLKNIIGRSQIFNLRKTAILQSIFHKFKVIATLFFMELIFEIIYKFMIISLIIRSSLFGYNIILDLAFFLKIITFSIQFYCILNLSLPEDKDAPETIFWEPSNNSRPDFLFYNPYIKESSIDFKFTDEWDESVLQPNNVDACDKNSEFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ2</accession>
    <name>A0A4Q9LSQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1686p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001686">
        <property type="protein sequence ID" value="TBU10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1686p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="767" mass="91477" checksum="325696ABEB14D225" modified="2019-07-31" version="1">MRVSNKVDIFKNTYTIKIIFTIGSILLIKNIKADMSIIFHFYDPQNQQECNLNCNKEEKMQFSNFIKQRYNCYEHEECIECTRYIIKDPSELILNLDDNKCNENNEKKIYICTDVCKYEDFLYFLKILNGIHDFKENLQVDDFILLIHILDMFKFKKDKKFKQLIRIILLSIIYNCQKNYNKGDLTKKNYISSSLFNCILYEFRKIYFFDLKPNFDKEERVSGEHIKNLIVENFDENFCSGKTYVSIKSEFLIKLSKYIKYNKEFRHGFKNIFKWIKPLRVALDSINSTSDVSTMLMSLIYFIPGEELCFQSWKNAVQLQYMLENFGFEKIRTLFFIDCNFLSFYESYFESFRSLKFIYLFNCQLLNTTISENNYKLVQNIVSIVYNEVEKLMSISKSAEKNINEPFESKLLNGEEFESSMKIFSIPHADYFRKIQIFFANTMPIYFPFVKFELSVLNPQKIRNIAIVLKRFCLSDLNFEGHCVNKNLKSLEIQASCITDELLYSVLLLSNLKKIILLYSKIILKNHETNYRTHILLQELVFSWCNFENQERIFKFINSFPNLKSLQITCNKGRDLFRHVFNYNMIKLVHLEKFIFEQERECISEFSNFTGKNSIIELNISYGSKAGFLYSLFSNNKLQNVRKLQINKFIIGARDKNSMVKCVKIRDLIMSNCRFTDISFSELFKIDNEYEIKKILLMDMILSKRDIIFISKLKHLRRLTLNYINISLDLIDLSHLVFRIHSKINMVMLFDSEPSSLEYHFDEFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV1</accession>
    <name>A0A4Q9LSV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1104p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001104">
        <property type="protein sequence ID" value="TBU11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1104p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="725" mass="85837" checksum="B2039DFB3918D406" modified="2019-07-31" version="1">MKNVRLLAIIHKPFHLLNQNYEFKNTLLENINIVFFVPEFLMNLESKKKCLTDYKKSIEHEFIIHTYIKKLAMKTLFSVYTIFAFLTRTLNASKQRNNKRIWRTNSTYQSNDDSTIDGFDNLSFAKIFLFQSEPSQQQKIQILQSEPSSQLPKTATLKTEYTPKKQESWQEHAQNRCINETSDYKVNKEISYFKDNSLHMTCSNQTEPETAVYSSTPLPAFYIAFPEKAMKEQISKPLEYEYIEDDEVNPEFSLPDTCSQSVIIDNSTVCSEEVDFSAQEFLYLNKAIEVPMKNPIPSNPSISKNIKRKKWLYIPSLNIFFNQKISQRSLNEVNHEYILIIKEELFSIIFTSNSIDNFNENNYYDDDLDEKNILENLKNKNSKFYPNENNFFSKLSRSEWCKKITEYICLNPFKNIENTKINLIFPELNFFTEFFKENQFQYIFKGHILYVYYLYEVISLITYSIPLNNNKVVKYKSREKKSCSKNLIGKIIFFTRNLLSELFYSFQKNPEKIQIYRLLNTLHYFSTLTIEKGKYFSIFLFELKMRYIFRFLFETNIRIEDGFKNDLFLGIICQLTNPSASKLIQRRLFALICSHCSVNIYMDKATALVNIYRDKFCGNKRLETIFNQEAQNIINLKESIKSMDFSQNKHDNDIQVLKILFDLEFRISHIEKAILGNSILVMSCYAKRGYGFTYNSIIKQAEEYYEDSHLSIEYFSIFSLLFIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT43</accession>
    <name>A0A4Q9LT43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1102p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001102">
        <property type="protein sequence ID" value="TBU11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT43"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1102p0010"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22904" checksum="F6D6E849E2D0F0D1" modified="2019-07-31" version="1">MLKYEKRKKIYEAKTNEIVRERSKEDIDDKWRIFANFKRNEWFDEECTSITRAKKSLQLEYTKKSAMMTQMELIRKYNTKHLSREMFRKVNDTRRAFITRTNSCRSKTGEIISDIQGVINRWSEHFRELLDMFNKLDNTGIYENIVPSYEEIHKAVEKPKNNKAPGTDEILNELIKNACGNYIKELTLYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT49</accession>
    <name>A0A4Q9LT49_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1196p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001196">
        <property type="protein sequence ID" value="TBU11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1196p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="79031" checksum="D45F149B7A3993D0" modified="2019-07-31" version="1" fragment="single">ECSYELSHILKMTNDITFMPINMSSYQFKCILTTLKYLKAVENKNMVKLFQALIFYDFVYHLNNGSKSKPLFLYGAFQDDFFQNFEFVIMKNFLFAFLNIFMMNYSFENGNLILLDKCRVSQDISLLNKNIPYKNIVIANFKVVYIFENILRNCYILYSFQALLNFLDIKSLIVDNYINLEIYEQNYNFAIFSIKTFKSISISNFTNQSSLGFLDKLGSVIRNDLEFLCLMNLQISRNAISLFLNQKRLKGLVLRNLIQIEDIDFIQDYTDCSKKLEYIEFKNVILKDTWWNYFLQVANVRKIILYFCTLLQQKNFMKEFVKIVSDKDVLYFEINFSFSGISVDFFPYLLYFRSLRTLKIYTYKNDSKNDPFLLEAIKNMKMLDHLVLQKIFIGRVFYNYLFQKSEIKVLHLKNIFFNPETPFLYFINNYKSLRKLVLTYIEVSSFGLIEIFKLENLIDLTLDFCVLHKTLMIPLQHLNFMSKKIVTLDLNNTNLEIFDEIDILGNLCCLESLNLSECMASPGYLARLSSKCNLRLKIISYESGILNSYDLNRLKNLEVLEEFNLSNCIFYDCKFSDLGKDCKFFNTLKKLDLWLVDIDIEDLKYFINFKNLEKLYLKLSGLNIYTIKKHLVTLPVYFLSIINTDNQTPTKYLFNYLYEESIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT51</accession>
    <name>A0A4Q9LT51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1040p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001040">
        <property type="protein sequence ID" value="TBU11783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1040p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="14685" checksum="503FCAC456C595AF" modified="2019-07-31" version="1">MGRRKKVESENIKNEKIKAVNNLENSAGEILMCYIDVAMLSERIPPPPTFHNTTHQPPSSSCQTSLVCLVDTIPSSSANGMTNLNTDAILEGNRLMVLHSILDSVTVIEQEWPRSAILANARNGWPATLRYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC6</accession>
    <name>A0A4Q9LTC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1018p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001018">
        <property type="protein sequence ID" value="TBU11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1018p0030"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020251098" evidence="2">
        <location>
            <begin position="16"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131066" checksum="991E66128EA29390" modified="2019-07-31" version="1" fragment="single">MILILPTILISLISSNIIQIVPYCDQKCKNTLLLSKYIAEHMKGPINSNSSLPFILSYDHNTSLTHLNLTPNEHTTGNNSKILTNTTGSYYTSKDIKGSYTQYNTGNTTKGSYNTSNSTKGSYTSYSSTKGSYTPSNATKGSYTPYSSTKGSYTLYSSTKGSYTPSNATKGSYTPYNATKGSYTPYSTTNSTTAYTPYNTVNTSNSTTGSYYIPYSSKNKESSKIPKINSSGVNNTLPIISNELSFKIKPFNDKEKKYIIKGSKYIFDKNNTNNNNSPHLKTLQSQLTNFLSRSDIPYYSSEIKVLSNKIDTLYNIVSKLSEIKKIDDKASSISEGVKDNVNVKGVSDIVNVKGVSDIVNVKGVNISTVKQQGVNISTGKQQGANISTGKQQGFSNKVNTKSVNNTNNNTPLPLYTPFKYGNLYFLPFQAYNTPLEYNSVINKNIDLNYTQPFNYPHNSNSDYNPYINTPPYNNPYFTYDYNTPYNTISSSYTNTHYNTVRPSYNNTIPPSYTNTPYNTIPSSYNNTPYNTIPPSYNNTPYNTIPSSYTNTPYNTIPSSYTNTPYNTIPPSYTNTPYNTIPPSYTNTSYYYSSYSKPNTTITPYNTSLISPKTTIKTITKIKKINHTLTVDHPITITVTNSIVKPISATILSDSSNSEDTTSDSNIISPVISSTISPVISIDRFNTYNEDNVSNSVSYSKEINTVYNTTDSRNPNPNLTLDTRINKSINTVNNTHVHPNPNLTLNTRINKSINTVNNTTTYSNKPYLKGKKKIKRIYKKKIPNTFNTLINTVINTNTTYTNTTYTNTTYTNTTYTNTSVLSTTAIVTTHTNTSVPSTIDTNTSVPSTSYTNTSVPSTTYTNTSVTFNNLPVNTFKGIISSIGVNKPSYKPLDSNNRVSINKSITYNNIKGVSVDEGEGGVNNNSMLEGVNNRSIKEGVNIMSSKEGVNNIGSKEGVNNIGSKEGVNGIDILKGVSNSIYKLDGVNDTTNKIGVNDTTNKIGVNTTTNKIGVNTTTSKEGVNTTTSIKGVNTTNSKEGVNTTNSKEGVNNGRIDSQISLENIPQKLSVSDLIGILNEKSKELPLNNMNSSTNSSMNGNINSVIGDIPYDISLRNLLYSVSNPNKEDELRYLDRFKRDTVRKRLGRYYVGDNYTDEYLKGVNNEGSSIRPFNYTDEYLKGVNNEGSSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI4</accession>
    <name>A0A4Q9LTI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2284p0020</name>
        <name evidence="4" type="ORF">CWI38_1191p0010</name>
        <name evidence="3" type="ORF">CWI38_1642p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002284">
        <property type="protein sequence ID" value="TBT97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001642">
        <property type="protein sequence ID" value="TBU10624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001191">
        <property type="protein sequence ID" value="TBU11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2284p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1191p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1642p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="163" mass="19129" checksum="B2393014DFE7FC6A" modified="2019-07-31" version="1">MILFYILPLIYTLKLKIKESSPSHGTLSVKSSLQQNSFLSLSFPKQVFPYLFLLENINIYKIYYTNDILHAILFFESNFQIQINYKKNLYKIHDYPINIDEGITFPKSILITKSHIIYSNTITDSIYIPDFTVPFISFSICGSAFTILLNLVVKYHKKNYKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT2</accession>
    <name>A0A4Q9LTT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1350p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001350">
        <property type="protein sequence ID" value="TBU11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1350p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15996" checksum="92F9DDB246F4966A" modified="2019-07-31" version="1" fragment="single">MYIRFEYGITKKRCPDIFKDKKIMFKEHDISFLPDILLYLKESDIIEIIAFNERKILTLNVKHSHRSPVSVNFITQNEIVLSKELLIKIIACYFLIFEDDEINFLEAFNYVDIVKHGYKILEKRFEAIKRDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT9</accession>
    <name>A0A4Q9LTT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1145p0010</name>
        <name evidence="8" type="ORF">CWI38_0930p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="PITJ01001145">
        <property type="protein sequence ID" value="TBT99999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000930">
        <property type="protein sequence ID" value="TBU12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1145p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0930p0020"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="142" mass="16406" checksum="BD4413936C365596" modified="2019-07-31" version="1">MKIVLQKVKNAVVYMNGEIISSIGYGYALLVGIQKNDNEDKIEWIVNKILKMRLFNEWKNNIVDVNGEILVLSQFTLFARFEGNKPDFHLAEKRDIANTYIKKVIETFKNKYSILKIKEGCFGEKLEIHLVNDGPTTILIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU2</accession>
    <name>A0A4Q9LTU2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0972p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000972">
        <property type="protein sequence ID" value="TBU11934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0972p0010"/>
    <dbReference type="OrthoDB" id="2190184at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="35262" checksum="BC263D65D6DA1854" modified="2019-07-31" version="1">METVFVNYKDINGDINIKYTGIYDEKISKIMFLFWQIQEQNEIFVAGIVFEMKEKNIVYISILDSTGEFKPRNMQKGFINGIILALLKYLSPTFLEVFSQPKKEIIFGKSSKNTKKGFLNSHKLFKYWKNIFSEYICCENKKEYKLYIHNNTDESNGIPYHRNTKLNDIYLFDDDPKQKLINNLEENVDIYNFFSILLFRSDFSNGSLLFNVCPCKKHNSNINLEEFNLFDIKEILETLRGLDFSDYQNSLKSTIFFLKKYQLKSFLFKTSKSKLSENIIEKPIEEQSFVKIKTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV7</accession>
    <name>A0A4Q9LTV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0914p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000914">
        <property type="protein sequence ID" value="TBU12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0914p0030"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="16050" checksum="0B1B2A966E0B4242" modified="2019-07-31" version="1">MSAYFDFLYENMFCFGELKDFEIKTETKFISKKDKILTIIGENENKIDIFCCCHILTSLRYTSKSKKLNLGENDYSNSTHTFNQITTKRFLYSVDKYALEPIQFMTRADRLEYLVFFSSYKKYQEKYQFEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX6</accession>
    <name>A0A4Q9LTX6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0906p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000906">
        <property type="protein sequence ID" value="TBU12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0906p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="44332" checksum="7CFBD2D2C4CA479C" modified="2019-07-31" version="1">MYILATELERGLHSVELRSEHMLMQLLDFLEKSKEISTRRAAILKVKNNNKTHLALLKAFLKSLIKGFLKAKYRLIEKVTKKSLEEAKLTRLYIEKRKLHSKLYNARKNELVSVSDSSRWPKRGNIRSRKEAVFCYIQDINVFWRADGICQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVLRCIHLLHPNRYKFRSSKRIRSHSIQEIFDNEYAEIRVDTRIKTDVKIRKNRPDIFILDKKNKITLIEEGITSQDSLQIAEIEKPKKYDLLAYGLGSIYKCRADIIYYVMTCNRIVTKYNKSHLKRLEIPHNLEACIQSIGTEKTVETIFIERRRGLEEHHYVSRDVLGTNTTLKTFDSKQKKTHFQKEEPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ9</accession>
    <name>A0A4Q9LTZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1312p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001312">
        <property type="protein sequence ID" value="TBU11231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1312p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020776407" evidence="1">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="276" mass="32174" checksum="05DBFEA779AEA406" modified="2019-07-31" version="1">MYFFTILLVQTVFYSKILDATPRDMNNDLENFNYSDVKLLEEKNRATFESKESECFHIILTNRHQDVIDDISLVMPDFKVILEEHMKLIKPIFEDSMQESIKEKLKKLKNKYIQCCSQLNILIENEISDLDENLIGLKFSDPYFISLLHKIKGGRENETTLTSKEERIKLIQESIKGEEFKKFLLAEVYLGFSEKMNGFLSSSSKRKEECANAEIGTFPSIIKNFLVKLKNRIKSSTHALFNIYKVQDSVFKDIFSEFAKKYGLEDSILHDNDPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU91</accession>
    <name>A0A4Q9LU91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0991p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000991">
        <property type="protein sequence ID" value="TBU11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0991p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="92808" checksum="2E80030DC2CC7EEE" modified="2019-07-31" version="1">MDLLIYIILGFIVIKSFVIFYTKKGKNGITKSVIILLSFGFCSSSCSGRVTLLLNASFCKENSDINKIHNSAIYSCKIHNRLEICYEDHTFKNNRIQCMKFGINVTHFILKKYIVEYPKDIPLISKFIERAIKSASNKNVEIILEKYYYDDFLCLMRILNAPDNLITPIVGLDLNFVFNFLLDFEIVYSKNLKYFLKSLGLNFFLHCKFSNRLNQIDFSKCLSSGINTSLVVVFVEQYLRFTFTRFQKLNDLCPRHPYSLHLNRDFTHNLFSKKSRIIVLDSNKSFFDEFLRKKILYATLKLLLNAMKLKKLVISHISQNFNCDPNKFANLIPFSCVKIIIKMFRNEQTFLSYIYPILKRPMIKKLKLSMNEISFETIEFLKQLKNINKISIPYYLPNNINIIEKILELPNYMPATQISLTLTNEIIETLSLLPKEYLNSMTNKNLALHIDFPKNIDILFSKIYKTLNLENFIETLKIGCNENLNKNQAKILSMFKKIKDFSLFFRIIGDSPYYKLQEFDFVSNFNFMKKILIFNSTISLELFYFVFHSKTLKRVYFTQIDISEAMNSNFNFPNFNFCVEKFYLKQINRPFNRNLLEYLQCFKQLKFIEISSIAPQLRIHFDIHFHTTNDKLLEFFNDDKVDSDGFLYIKKLNMCQITFDSELLNGIFDKHWSLKNICELNLASTILYNKDMSFLSSLKLLTSIHFEKVKFVNCFFSDILSKYMLKNITVLYLDNIEFVKNDFIKISQLKNLELFSAYFGDHFSINRIKFVSLNDFLFHLETRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM1</accession>
    <name>A0A4Q9LUM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0825p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000825">
        <property type="protein sequence ID" value="TBU12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0825p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16198" checksum="B6F6E63A1548D7BB" modified="2019-07-31" version="1">MRRLESGLNAEESWERTSMGVIRAEMLEEPTFPLKEAKRDEDGVKILKTKNNTPLISQGGTTLEEPTINITEESDLGEETTVMQRKVIMLFSVLFLALVFTAFVWYYNTNLKAKSNNNSNEEEPERILEKILGRFQTPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ9</accession>
    <name>A0A4Q9LUQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0905p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000905">
        <property type="protein sequence ID" value="TBU12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0905p0020"/>
    <dbReference type="OrthoDB" id="8063979at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="627" mass="72249" checksum="0C73C70D0F4C016D" modified="2019-07-31" version="1" fragment="single">KEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKYIKVIISKWKIDISVGPEKIMSKKIDRGILQGGCLSPLLFVLCMDPLSRKLNEKYPKVTVQTDAESYSTNHIFFIDDLKLLAIDSSTLSAMTGEAKEFLEVIGLEINKEKSVTNDTCCEDTATLLEGVNSRRIPTRTSFEDVQSKLIARVERLFHTRLNAKNLFSAINQHAISLISYHIGNKILLCPGCKEHLYLPRTQLGRGLHSVDKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYKARKNELLSVSGSSRWLKKGNIRPRNEVVFCYIQNRNVFWGADGLCQRCNKSGKTVDHLATRFEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIKSHSVQEILDNEYGEIRVDTRIKTDVKIRNNRPDVFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYNLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNEETYIQSIVLKKTLETICFDRRKGLESGLNAEESWDRASMDENGDKTENKKNNTPHISEEGTTLDEPTNNINKESDLEEETEVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT4</accession>
    <name>A0A4Q9LUT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1240p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001240">
        <property type="protein sequence ID" value="TBU11375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1240p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="662" mass="77173" checksum="00573EA0C6F0BBB5" modified="2019-07-31" version="1" fragment="single">KNLQNLHEIQPSIAENKNDILNKYFNWYKKNVNEDTQYNDILYVLHDPTQNEALMNHNIDINTIVDQNGNPIPDAKSKREILVNFLLYYKSFVNPNGQDRHPHAKKRHDISKKTYAISDINKNFKEDVNQNIQKPINYSDLDSAETHSNEKYDKFVQIFQNQENTETLNSLNNNDFNENHDIFPPQYFSNTYPGATEDKIDFYPNTTESNMTKSKYPDNKSYMPGVHSNIYRFSNTDDKIDDSGIPYVFDRNNLEVNVMFREEGADSHSNIGAEYKNPNVSYTNYFNILSGLDSNTTKNTKNTDKAIKNFNIAHQKTHLCTLHMSESEYFTYGNLNYGVIKEQGENNDARILGNIESGNILNKNSYYNSLYDDINSNTTKDNESTNLSNSAIFPVQNPSTDSRNFLQQKMNLNTFKGNGRYDENNISKATDYMPRDSESNNVQRKTNIFLIFLKQIHIKEKITNNNTCYLSIRLLNSMLYEWLKKGNIRPAHEAVFCNIQDRSELWGAEGMHQHSNNSINFENEYAEIRVNTIIKTHVNIRNNRPYIFILNKIKIENHTFKKYDPCLVDELGIDLKFCDNLSCDQMEWYCRCLHSADNDQKSKPRSDLKTEKCWNRVYICVIKQPKYGVKRVRTNNIGPFIEAAGTEDKDKRNGDYKLNFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV6</accession>
    <name>A0A4Q9LUV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0751p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000751">
        <property type="protein sequence ID" value="TBU12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0751p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="609"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1141" mass="132387" checksum="D4C0A6F87285CCCE" modified="2019-07-31" version="1" fragment="single">MSEDQLIYEYALLFLEDRVILGLEEDIEEGIEEESDMIDYVSMFYKEDTNLYSNENTGNKDINLYPYNNYTLNSKYTLNTSNSDSISPYNPYNNFTFNNSKIKYSPFYQFNSTPKSKICIKKEKGLKREKSLERDMSKWRKGSINKEKSIGRYKSINNEKSLERDISIRRSIGRYKSINNEKSLERKNIKFYYCSVPFCTKIYTSSNGLGYHKKHGHKKVEFKKFRCFYVGCIKSYKNSNGLKYHLENEHYQENENINNDEINALNNSEISFKESKTCDRDVLTISETVPPKQIIYNNTHSPSSNTLQVTSISLLDSEIPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAISASAILRYYNGKFGRTVDIDVLKKSTHNEAESETRQEENKERRRIATCIAEPCSLTDTTLYINLREKFLDVVVRTRKLPNELVESNVLELINQITCEYAESHVPKNVCYDEETRKAKPRSAWKENIESKIYKLKARKQERLSTSETKSLRKIMREFNLDLSKINDISEALVKKNETLNVYEKKHPINESREKFRKRIVCLSLSEVDFIYADGIDCISNFYIKKLTSLHKYLSDIVKFMFLEGTPQADWYYCGLTYLIPKDTPKTGSDYRTITCISNLRKLLSDNQLGAVRGALLNVATNKEYGNNIKATWIDVKKAYDSIDKAYLTQVIENLNLPDWILKFIKGLKKNMNKDINKRILEGDSLSPLLFVLCMDPLSRKLNEKYSKGTIKTDAESHATNHLLFIDDLKLLAEVGQKLQEMTEEVKKFINNIGLEINKKKSDTNDPCCEDTASLLEGIEDSRGIAKSKSFEEVQTKLIARVERLFINQHAISLLNYHISVHRLEPADFSKLDDAVRAVLVKNKILLRPGCKECLYLPRKELGRGLHSVEFKSEHMLLQFLDCLKKHKDTSTRRAAILKVVNNITKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVKVFCYIHDRNVFWGAEGTCQHCNPTRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSIRVDTRIKTDVKIRCNRPDIFILDKRQYDTPHSIESEKLRKYDLLANELEIIPYVMTWDGIVTKYHKTYVKRLQISMNVEAYIQSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB7</accession>
    <name>A0A4Q9LVB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1316p0020</name>
        <name evidence="8" type="ORF">CWI38_0688p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001316">
        <property type="protein sequence ID" value="TBT99514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000688">
        <property type="protein sequence ID" value="TBU12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1316p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0688p0020"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="119" mass="13790" checksum="613009662DA48C84" modified="2019-07-31" version="1">MSLYKLLDIEKNASKKEIKKAFLKKSLSTHPDKGGDSKDFQNIKKASEILLSDKKQFYDNLVKNEKTFKEEYLHDTYTLKNIQNNSAVCRCGGIYDIDDQFDGCIPCRYCQCYIKISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB8</accession>
    <name>A0A4Q9LVB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0688p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000688">
        <property type="protein sequence ID" value="TBU12628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0688p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="372" mass="43469" checksum="C99348BCE139A769" modified="2019-07-31" version="1" fragment="single">AAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQIAERVMKIIKNQTDPSIIEYIVPLIIFSITNENRKMLMYLQKIFRKVDQYSKDNKMGSDNLYKIFTPTIFPNIECYDLQSINLQIEIVKRIFESNLTEIPCFLYEEALSIKRKKFIFTINQHAISLIKYHIGVLRLELSDFSKLDNAVRVVLVKNKIHLRLGCKERLYLPRAELGRGLHSVELRSEHMLLQLLDCLEKTAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNEFASVSQSSRWLKEENIRPRDEVVFCYIQDSNVFWGVDDVCLNCNQSGKTLDHLARNVEEGLYKTPLSDIKRAEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE4</accession>
    <name>A0A4Q9LVE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Yos1-like protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0712p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000712">
        <property type="protein sequence ID" value="TBU12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0712p0030"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9030" checksum="B0EFBC422223FF37" modified="2019-07-31" version="1">MFGITKIFYSLIFFANSLVILNEMRFLAKLGLPLKPEARGSLSGTRRKIVDLLRASRTLLRIPLIFINLLCILYEVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH5</accession>
    <name>A0A4Q9LVH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0665p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000665">
        <property type="protein sequence ID" value="TBU12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0665p0020"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="9">
        <location>
            <begin position="507"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="913" mass="106767" checksum="9E5593F869B9FAA7" modified="2019-07-31" version="1">MKKKIGKNRKDKYYSMAKEDGYRSRAAYKLIQLNAKYNFLSDANILVDLCAAPGGWLQVASKYMPVTRKIIGIDLDPIKPLNDVETLICDITHDKCKKELKRILDNNKVDVFLHDGAPNMGACWNKDSFVQNVLVLNALKLSASFLKKGGIFISKVFRSKDYSSLLWVFNQFFTNVSATKPLSSRNESAEIFVICKGFIMPDKIDSDFFKPEKVFSDSDNNLKTKDILKNREKGKVGEYNDFKFYKIGLLSNCLVSKNLLLDFLTFSKIVVDFDIKNGKEVFDKIFDKECLFLCEDLKVIIKIKNLIEKKEIEIEIHSSNRKVETEIDNTKECVSDTVSEYSEEFSDEEKYSSEFTNSEDYESCSEEFNENDIVEENDTKIKEIERKIVKKSKETRKMETSRQIRNIKSLKQPLDNFYLDPLFNKRNKTSEIKSLPENEIYNESKSEQINYKQESGFSNIKPEISQTSKLENNIPVSENIKKDLDDEISESYSCSDSLEINEGELRSIINLKENKKDFALSSVNRYVHDDHKNLPSFYKKEMEELNRIRDEEINYEKFNFLERKNIEALDRRKRRALKRSEKVLKNIDFDSDEDREQLIKKIFKSSYKKTKSKPKVIFPRGKNINIPNCKGKVKLLDRRMKKDKRNNLKNLKKSNIGLEINKEKSATNDSCWEDNAILLEYIGEVQTKFKARLDDAMLKNHYTFQVSTSEELYNSINNELVSVNDSFSGLKKGNGRPYDKAMFCYRQDRNLLWGASGMCQHCNQSMKTVKILKKRLLRCIHLLFLNKYKFKSSKLIRSHRVQEILDNKDTEIRVNIWKKTEVKIRNIRPDISILDTKKYGILENVTVERIYFDRRRDLTPKCIISRAEMHKQPTPPLKQVDNEEDGVKKENTKNIFRILDGITTVKELTKYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT6</accession>
    <name>A0A4Q9LVT6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0653p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000653">
        <property type="protein sequence ID" value="TBU12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0653p0020"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="21716" checksum="AD7AC2C1C6CEDD14" modified="2019-07-31" version="1">MTLRKSRIVVLKDIEDKVTLQLLLDTFSKYGELRGLSISTRIRDDRKMKLGFIEYSDNNAAIKAVESGEVELNGKKVVLSYAKKSSLPSKPKEDPSRIVQNKLYVAGFPSDMSEESLSNLFGKSCSIIAPSGTKAGYVFAEFTDEETKDNFFKEFNGKEIGTEHKLSVSPAYAKRPFHKRKYGKRSSERREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ6</accession>
    <name>A0A4Q9LVZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_2187p0010</name>
        <name evidence="7" type="ORF">CWI38_1014p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002187">
        <property type="protein sequence ID" value="TBT97568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001014">
        <property type="protein sequence ID" value="TBU11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2187p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1014p0010"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT97568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="167" mass="19293" checksum="0B01DC5423644BC1" modified="2019-07-31" version="1">MAANEGKRSKAFIEKEFKRLQERANEHFSVGLVDDNIYNWEVLVFGPKDTPYENGIFMARMTFPIAYPEAPPTFRFVSEMWHPNIDKDGDVCISILHKPGDDEYGYENLSERWMPVRNPESVIVSIISLLTSPNCESPANLDAAVDFRESPDKYFKKVRRLTQKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW24</accession>
    <name>A0A4Q9LW24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0609p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000609">
        <property type="protein sequence ID" value="TBU12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW24"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0609p0010"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15072" checksum="CDD392EA50A9E739" modified="2019-07-31" version="1" fragment="single">MNLIIIGPPGSGKGTQSKLLSINLNLYHISSGDILRDEIKKGEFISDTFMAEMVMCRIGEVEGGKGIILDGFPRNLYQIPFVTIEISGVIFLNVSKDICKKRVFQRNENRSDDSDIVFENRWELYERSTLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC6</accession>
    <name>A0A4Q9LWC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0059p0010</name>
        <name evidence="3" type="ORF">CWI38_0974p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000059">
        <property type="protein sequence ID" value="TBU05019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000974">
        <property type="protein sequence ID" value="TBU11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0059p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0974p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="260" mass="30806" checksum="D83BAF8220242AA0" modified="2019-07-31" version="1">MSESKRKRKDIKGIGKKNFDFPGKIMVHIFLYIFFICFAILICCVVALYFDIIGKRSLKIYIAKYTLLASILNITLILNGKKRIDRLSEYISGSVIFVFIFFTFISEMYINTFKFKGGLASKIVLAVMKVFFKSAYSFYTSFYIAFVILSVFFKSVFWLYISFYFNDCKFIRKRTHLCNILRYLLYIYILIIWETVCQKVFKSKMKLFLFSKLVCYIIVIPISYIFMARKNDFLLGSLLFIYYLFLLISIDFNTMIAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP4</accession>
    <name>A0A4Q9LWP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0512p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000512">
        <property type="protein sequence ID" value="TBU13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0512p0030"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15904" checksum="67A9BF8D41E71652" modified="2019-07-31" version="1">MPKIPINPPEGFTAIEDMLNKIDDKMKEAINLPIQKKYSHNFHQIFRFNHQRSRYIYNCYYKDKSISKELYLYLLDNLYADRYLISYWKKQGYENLCCVLCIDNSCICRVPLHKIPHTELVECDSCGCRGCSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW1</accession>
    <name>A0A4Q9LWW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0626p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000626">
        <property type="protein sequence ID" value="TBU12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0626p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="25547" checksum="79B1FBFCF7971ABF" modified="2019-07-31" version="1">MKFYEETNPHLQRLSSRFYDLSKETDFIAEKERQAYTFIQRNLIKDTSIDFARVFEERKLERSYFKHYNNENNYFEEFAFTAKVYYDSCIQNEFYAIPEKESPIKAVLTKLNSKLESLMKKMYINKVLLKILIDIFHGNDILYYISTEDQSFYTYNNLLDTNQRIGFFIDNFVNHLYFILKEKFEGLSFPKCKKKLKFKGIDILLKFLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX54</accession>
    <name>A0A4Q9LX54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0580p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000580">
        <property type="protein sequence ID" value="TBU12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX54"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0580p0030"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16340" checksum="9DBB2161836F0B1F" modified="2019-07-31" version="1" fragment="single">MNSPIKMHKRNNIIRDGKSQVVKDFPKGYATSQQTKTEKIQNELPKPEVNAPSLPSEVEKDQKIFFSFDTSSYPPPLSTTDFFVTETKNTDPNLLRSSFYVIPAEPSIFQSINLPLTTVLQPFNSKALINEIENIKSVRCMECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB7</accession>
    <name>A0A4Q9LXB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0559p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000559">
        <property type="protein sequence ID" value="TBU13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0559p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="42425" checksum="27BDB5C7DC6D0BA8" modified="2019-07-31" version="1">MISSKNISEENTNDKNIEDLYAKVIRRKKPKNTSIQETILMVECKPNEILNETTTSDQLSTIHQENQSNEITNVEPSNTIYQEISLNEITNIDKLNRMYQDSQPNVIPTANILYNSRKNEILSVGDTSGWPKKSNIGSYDETVFCYNQHTNVFRELENVDHLTTRCEKMLGHDYTKRHNEVGRCIHLLLLNIYKFKSSKRIRCHLIQEIFDNEYAEIRVDTRIKTDICILDNRKNKITLIERKKLRKYDLLANELDLFIIPKNVEAYIKYIVLKKAVENISFDQRRGLNSGPKSEESLKEPRINTNEKTDSEEEQMMVVPMEEIISVFFEEKGAYLFKFDRKNDVLDQCKRNLQYAGKDCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX1</accession>
    <name>A0A4Q9LXX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0389p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000389">
        <property type="protein sequence ID" value="TBU13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0389p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="133"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="50036" checksum="8B4E5E0EE393D2B0" modified="2019-07-31" version="1">MSKKICEHLSFDNFKKIEPKITEIYYKFINNINLKEKHINIGCSNCESKFYIHICLNCLTTSCFKNKHYILHLNENNHEFSFNIEKCLIYCIKCNKYNSINELSSLKCRKNTEILKSIRSYVNYKKIPELCVKGIQNHGNTCYINSILQIFINSRKIQNIFFSLEHQTKLCKMKNCLYCSIKIVLNDLFSNSKYTINITNFIYNLWKNENILIGNKQYDAHDFYLTLCQNLHSKNSNENFDSKNCNCMIHRMFFGTFISSLECQKCKNISSKIESFLSISLEMKNEHEIGIKDLKAAINNFLTAEPLTDEVSCLVCAIKTPAIKNVKIQSLPEILCFHIKRFRIFNKTPIKIEENINHPEFITLNNINYEIYGIVRHIGNLENGHFVSYIRLNKKWYKFDDECITCITYLEAMKIQAFLIFYSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ1</accession>
    <name>A0A4Q9LXZ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0360p0030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000360">
        <property type="protein sequence ID" value="TBU13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0360p0030"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="463" mass="54371" checksum="A5D37444D69B2EAC" modified="2019-07-31" version="1">MTKKLSQYQPTNKKIKTNTIQPTDILTPLQNTNYNENEIAKYLQENNRENSNKNRENSNNNKENSNKNRENSNGICMSSKNISVCKDICKDRNRNSKDKDSKYSNKDNNTTNTNNTTDNTTINTTDIKTNQQYIANQSTITINTTDITTNQQYIANQSTITSNTDIYDTRTINLNIINALIYNNHGNKDLDNTNNNIYLSNSISNNNIYLSNTDNTNIFNIHSVNNNDLRITRIKFKQDILNIDMDRDRDVVNVQDVGGEDIQDIILMCVRRHTQRRVEGAGGTQRDIQRLIDVIRQLTCNIRELRYFDLNPIIFKYGGYVKRLSDEELYLRMWGVFKVFERYKMSEYEIERLRVVMYRDIDILGDVFESSLGESSLSESSDVREKYDKEEGRYHNREENYKILKNVKKSYKNIQRLCDICMSEYKESDKCIILRCNHYFHYKCLKNWLLINSTCPYCRKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG4</accession>
    <name>A0A4Q9LYG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0308p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000308">
        <property type="protein sequence ID" value="TBU15711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0308p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6140" checksum="8CC092DD10915045" modified="2019-07-31" version="1">MGVIMRAEMHEEPTPPLKEEKREEDEEPTNNINEELDLEEETEVVKEVEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI4</accession>
    <name>A0A4Q9LYI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0305p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000305">
        <property type="protein sequence ID" value="TBU15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0305p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="16370" checksum="F2075BA926EF6E4A" modified="2019-07-31" version="1">MLEYEDMKKISESKTNEIVRARSKEDIDDKWNRLKQTIVGALMNERNGWIHPAKNRQSTMDHLELIQKYNTIHRSREMHRNVNDTRRAFITRTNSLINRWSEHFRELRNERGDQADTDNVFDELEDMGSYEDIAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK3</accession>
    <name>A0A4Q9LYK3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0293p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000293">
        <property type="protein sequence ID" value="TBU16705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0293p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46189" checksum="C203B8805BDF21B4" modified="2019-07-31" version="1">MLRYITSEAKMIFKDVWIGNIQSKVGQKDLDCEDTANIPEGAYVYKYLGKMKDSRGILTRSSFEEVQSKLVSRVERLCQTRLNAKNLFSAINQHAIWLISYHIGVLRLEPADFSKLDEAVRAVLVKNKIHLLPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDSAILKVVNNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIKKRKLLLKLYNARKNELVCHEMKLCSAISRMEMYSREANGLCQHCGKSVKTVDHLATRCEKMLGNEYTIDTMKCSHSVFEILDNEYAEIRGDNRIKTDVKIRNNRPDISILDKKKNKITLIKVQITSQDSLQIVETEKLRKIDLLASELGFFYKSSVEIILYMMVWSDIVTKYYKLYHKNCEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT5</accession>
    <name>A0A4Q9LYT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative SET domain-containing methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0576p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000576">
        <property type="protein sequence ID" value="TBU12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0576p0010"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="426"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="66351" checksum="8E6CBDC147B7C217" modified="2019-07-31" version="1">MDPEKAVKNIISDAENEYKDEICKILNDNQKYLNLFRKNIPSSSIQPQSYRTNVIPFIQPHPRYTFYMDAPKNIPSQDDPILRYIPYINTTSHENSVNIINYDETSLKENPLNYKEELRERALIKTFSHYSDLDLFNLKNLYDQKDPTVDVHLKNRFPLILAVIKTMDLSLECILNHWEKYFDTRPKTLYNDNNAFREHFCHVCMIFDCGLHEKIANIVVKGNTHINQKIICNCNKKSIKSEYQNPKKNQITDKSCLSQKNKKIKSNSSVDHTAIARVLNNASKIIPLTSCLSSLFIKFAFQWDVECNILQNINYVALSAEKFNVPIKKRPKFCTNKIVKFAHDEFFSPCVHKGSCYKNEECKCYKLNMFCEESCLCLECDNIFEGCKCKKCNNKCQCYIYYRDCTPKCGNRYRKPETFKHTCFNTDLSFYNSKTCFIGRSFVEGFGLFAGCFIKCDSFVGEYIGEVITSEEAERRGEFYEIRKSSYLFDLCHKNGDVYHTIDASKIGNACRFINHSKNPNLRAKMFQVMGVKRIGFFAIRDIREGDELFFDYNYNQEQKKNYDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW5</accession>
    <name>A0A4Q9LYW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0265p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000265">
        <property type="protein sequence ID" value="TBU17874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0265p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="50872" checksum="45171E92F2CD0E2F" modified="2019-07-31" version="1">MLITTFCTKNPTKTSKCNIKNLFNIINKKIYELYTEKTKKYDEICSHEFLFLESSNYLLKESSDEIIEFLLAKKSKKIHIIVSLINNTEMENGTVYYHSLTISYRYFMIFRFRNNRRPVSNANILNRNYSTNSKPSEKEYYLQKHSSKFIFWHLNIFKRILTKIILKDKQFSFVPIFSDLAFLKATDHDFIFSMLFKQTYKYNNDYFLLINDLKINKHYDLNKKNNKKILEYAFTSAKFELIKNISFERKDRVTQSSKGCLFKNVCNKLVVKEICLCGYKKYLNVNEVYISSLREDKKQDSINKGILNNFGYISSDIDIFTSVTEDKDNTLNASNKSKKPKKNKKILQETCYLTIFYRETSTEYIINFLYNVLNYDLINIYITRSIPGFSCDMPLKEKISFVLVLVKELERFDFKLKYWNNFKSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ1</accession>
    <name>A0A4Q9LYZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0259p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000259">
        <property type="protein sequence ID" value="TBU18002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0259p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020769190" evidence="1">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="55650" checksum="7D0B14EE20310EEC" modified="2019-07-31" version="1">MLILKIKLLFLLITYTSGSSFFQSFLENNLESKKQKQLLNEFHEFQESQLGKLLKDQYKDNKDFGFVMIYFGESIFLDLCYSGCKLKDITDDISSLLELLRKRSYVEENSQNETLKKVSEWIERLNLVVLPFIFSLDKFEKFTSEYSPDISAQAIRCVTEKLNVIGFLHKFGTFVKECKNHIEMFGLLNVSFNDSLLNITLEKYINHDFHTVKSFQISLDHSDPRAFFVFILYKANIFDKNHVYDSFLKKIYPDTVLKQIIGDALAAEIKTVDGMKEFLPAYIPKIEEIKEKLNAIEKRLKNIESLGWVQSALVNLSLWYWKTLVSILIEQKEVVCNYLDDPDTFFDMIRTLILTKKLEIFLPIFDKFKKTNEEVLDSCLAAIKVFLLKFYKEFFEKKFGKTEEANLLGSIKFLNEEILKLSKNSRFLDLYVSILEIYKENCSTDSKEIIMIFSRTAKEFFLAYIRLYEAILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ09</accession>
    <name>A0A4Q9LZ09_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0252p0040</name>
        <name evidence="2" type="ORF">CWI38_0502p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000502">
        <property type="protein sequence ID" value="TBU13210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000252">
        <property type="protein sequence ID" value="TBU18151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0252p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0502p0030"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8572" checksum="0CFB8D63B05C39D7" modified="2019-07-31" version="1" fragment="single">NNQLQTELLIEENEIQNLRERVRENIALQINELGQVVSDISLHVSMQGENLKRIDDLMGDSRGFVQKKIEEILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ52</accession>
    <name>A0A4Q9LZ52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0255p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000255">
        <property type="protein sequence ID" value="TBU18014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0255p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="44241" checksum="DE1DA863A90B6D6E" modified="2019-07-31" version="1">MNHFLDEFPSEKRNINFLMKLVSKEIKKTNYEQILNLKIQKNNSEMLENLNNKKIIKKKPIKTSLKKILKEEKNNLEKIAFKIILNKKVRFDNFKTKLFFIYKFDKIWKFDYSLKFKKHEYILQELIFILFYQNLNENEKKENLNQIYNIFMKLKPHKKTLYYLLLKDIIEEDFFYKLISSLENHPILLTFFTNQKFIYDPSKLIVKEILNTCSTMKYKIISAVCNSEIEKNHFLTVLTKNYTIYFITSLDKKYFEEILDLLTFFQPNNTFQTFFCFSWMRTFLFTKNLELFFEIYNFYIKYNKKTENTEFLIYKYFCDSFLFFKEKNIFNLNIFKESCNTYNDTNEEYYVKVSLLSKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ96</accession>
    <name>A0A4Q9LZ96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0380p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000380">
        <property type="protein sequence ID" value="TBU13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0380p0050"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="403" mass="46841" checksum="2F597FF504F07620" modified="2019-07-31" version="1">MKLDNISRKDSLEIDFVPIYFIQFQSTNHFLIIDDLKLFCQIYKTLEKMTEEKSETNNPCCEDTASFLKEYSLNKIQSEGIPQLKRLCCTKPNVNNLFSAINQHAISSIDYHIVLLRLEPADFSKINDAVRAVLRLYPLKQNLEDVFIVLSCELLDSREKSKKISTRRAAIFKNLEKAQLAKLYNEIEKRKLHSKLYNARKNELVSFSDSSRGLKKGNIRSRNEAVFCYIQDRNVLCGSEDICQDCIKSQILENEHKQIKGDTKIKTDFKIRLGITSQDSFQIVETEKLRKYDLLANDVEIISFGINWNGIVTKYPRKYVKRLIVLNKTSGINAEESWKSGPEPTPPLIQPNNVEIVLNILKQKIKNLKFWIEELNININIESDLKEENAYYDKNILNEKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA5</accession>
    <name>A0A4Q9LZA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0242p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000242">
        <property type="protein sequence ID" value="TBU18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0242p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020443064" evidence="1">
        <location>
            <begin position="19"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="607" mass="72624" checksum="1DA362FA39F0160D" modified="2019-07-31" version="1">MKLILKLLLIFIPKKTLCSWLGHLSDNSQERDRFEINEYSNTFSSESLFLIDEEEYNDPNLESGFENYSYTYDEGFCLGSEKTEPDPLFADVLVDFSTSEIEKYSVDYSENSVQPNNTSSDNTLQKGKTSITNKCILKNVLEGKVEYVQVSNKQSHNYYSKSDLTHKIPQENENRKENTVCGEDIEKSKNIRFLQKNELNQKKRKDTLLNLNVKQNLNKRHKFPPISDSDKIKAIRNIGYLHETIEEIISKNTCEDISSNFLRFAEERCFENLLSQKIHSMQNKRIKRHEDLIPYFEFAKKIICFEKKNMKNLSNEQMNNFLRELDLRKFEENISNLKKYRILNEIYFFIYSYNKGSIVVKKNHVVYVSFMFKLLEIWHSNLVDFVGLKNIFCFKYNSFVFSLRFIFYNLLFGIENFDSRKHFYIIIGSLIYFNDIGGIKRLRHKKKIYCLQLNILCQCVFLRDFNNKYATSAIEFYKSNVMSSSESSFSNQKYFFKKFFLNLKDMDLIRQYIGTYNLMKKISNFSKIYSDFNEDLIKISTKYDNKEKIEIENEEFIEVLFRLETMIKWTHSKIIYSHHKLRDNFYLERSRKILKYVHYLLMKLFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ4</accession>
    <name>A0A4Q9LZJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0220p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13410" checksum="B6BA4308E6D2C3D6" modified="2019-07-31" version="1">MDREDQNYYKPRTNQRYSKESTTDTRKNYPTNTTYRYTRDTSKEHTHPSPYDRRRDNESMYPRNINNSYGRRYTRYDSSTYNKGVRVVRKGIPTREELDEQLIKYMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M046</accession>
    <name>A0A4Q9M046_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA polyadenylation factor Fip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0015p0020</name>
        <name evidence="8" type="ORF">CWI38_0171p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000015">
        <property type="protein sequence ID" value="TBU05412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000171">
        <property type="protein sequence ID" value="TBU19925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M046"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M046"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0015p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0171p0030"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU05412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="191" mass="23470" checksum="72C4335794F0D003" modified="2019-07-31" version="1">MSDIDNNDLAFEYKCEDVETSSELEIIAEEQEKKDELKVALESQNYTGQGVFEFELDTLEEKPWKKPGEDITDYFNYGFDETTWRMYCEKQKGLRTEYTPSRTFETKSVDRKYNQNSYYDREERDYREDSKYFSKEYSQRYNDRYNNDSRYDDDRTPNRYRRPGTYDRDEQRRRRGGGENDRGQYRRYSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M077</accession>
    <name>A0A4Q9M077_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0250p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000250">
        <property type="protein sequence ID" value="TBU18159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M077"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0250p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12545" checksum="84F6189DCECBE64E" modified="2019-07-31" version="1">MLLQLVDCLGKPRDTSTKRTAFLTLGTIIKPTLTIKMLFKSRIRVKEKVTTKKSEEDLLANLYTKSKTKTKFKVIAYRNNKLVIYNDSLKFARKGRLIPREEAVFCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G2</accession>
    <name>A0A4Q9M0G2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proliferating cell nuclear antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0129p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0060"/>
    <dbReference type="OrthoDB" id="2190999at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="27286" checksum="55E4899591A885F0" modified="2019-07-31" version="1">MKLEIKDVKFFVAILKSFNSKNKITFKFSNETLEISAINNLRQYIILENIIFNYIDYRDIIFTIDHSLLLSYINHFKKNLCLYIDNNLNLTTKSENYSLFVKIPFIDLLDNEYKFVEDSKIKFILKPEQSKILAMFKGIVTYSLENMNLIIRREVEESNERIVINDIEIIESNYLYFKCLNNWANIFEELFGFIEGTLFSFNENILSIQFLFKKYENTYLEIQIPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M170</accession>
    <name>A0A4Q9M170_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0069p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="772" mass="93982" checksum="1B76C85CA1C33528" modified="2019-07-31" version="1">MEFNLFFRFIKSFYKPIILVFIYHSSERDIIFNVVNENEEFSIASTIKKIKLECLCRIKRDEMNENEGKMLVRDSNRQYEQYYIEFIERIGLRFDIFEKFNKMNNNIEIYLCHHIKKSDFLIFYEFIISYYLPVHKMTIKKFYTILYFLEYFRVEYDNKLRKVIKNIWCSLIESNEIINFDIEKVSFHFSKQDYFSHDLFKRISKGYFELLTYRMDESELFFRKEHESYIYEEYKGLYTEDKKHTLVINDEFDTFFYKKVVVNHKSQSLFLIFLNTLDIKYLHIKYLNVFYSESFCNILENLKRMIDEIVFFKCYIYDKVIRSLNANINFVNLKKIVFIKCKFDTIFIFTEHLSNIQEFIFYENNNYEIYRVPEIKEGNLNIAEYIIKSLKHPDQQFSIEEFLKKNKNVPKENENFYLKLLNEDNFKGKVGIITYFECKNYNLQVKCFYEYKGSFNNISITLKKLNKRSFFTTENTILEKNIKCIEISSSEIKSDFLRDILNKKGLERLEIEFSNIYIENEIFTNESINYFSFTPKNSDSFRIFFKLIYMMIDLQEIYVYAINTWKLTRFVNRIFYIKELTLRNTHEMIDLLKLSENNKNIALKITNKDISDSEYPKDSLKFLFQNYDLSSIMKLSIRNFLIDNLDVKAFSNLSNLKEFKVFRINFQNIGFSELFCNSREYKIKRMDLDEINISEKDLIFIANLKKIEKIIFRNFNIQRKTYNCIQMLFNNEVYIELKYYKIFDYLSEETIDFIEEAFKTKYIVIRNGVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B0</accession>
    <name>A0A4Q9M1B0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0316p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="PITK01000316">
        <property type="protein sequence ID" value="TBU15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1B0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0316p0020"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="8">
        <location>
            <begin position="274"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="668" mass="75871" checksum="2E29E2604B297E46" modified="2019-07-31" version="1">MNWDENQISSIDLLNTQPLLSDEIIKQQYQSFISSFQHDERYIYRTPKSIMKINLQHLSAYDFQLFQELKRRPLHVIQIFEQVTSKLELILNVSPISIRAIDSSYINKIIRIQGIAVNASQVIVKPSSLFLQCKSCLTTRILDYIPRSCSNQCSMDPFTIIPEKCQVLDTQYVKIQETFQDIPPNETPKHATLVLENNLINRITPGKEVSVTVIYGIKETHSYFKVIGINSEERDTKCFTEEEELMFRQISKGVLPDENNSEPKNNSELKNNTAYSLIVKSIAPFIHGMEDVKKAIVCLLFGGTRRILEDGITLRGDLNILLLGDPGVAKSQLLKQTCNLSPVGVYTSGKGSSAAGLTAAVIRDSKGEFCLEGGALVLSDGGVCCIDEFDKMDLKDQVAIHEAMEQQTVSIAKAGITTSLNTRCSVLAAANPTFGRYDNYRSIGENIDFGISVMSRFDFIFIIKDECIRSRDEEMARHIMGIHKDSKNMGFLDTEILRRYILYARSKIFPSLNDKARDRLCDFYVNARKNIKKWEKMGGEKSIIPITVRQLESVCRCAEALARMELNENVCEWHVEEAIRLFMVSTMDAVNKGYYIEGMNRKGIVDEIRILCDKIREMLPVGTGRSYDSLRDRLKDYGDEKINRAIEYLVKSEKVVLRNMGKVIVRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E8</accession>
    <name>A0A4Q9M1E8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0056p0020</name>
        <name evidence="2" type="ORF">CWI38_0060p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000056">
        <property type="protein sequence ID" value="TBU20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0056p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0070"/>
    <dbReference type="OrthoDB" id="106984at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="191"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="393" mass="45765" checksum="AF1CBA8309DD72E7" modified="2019-07-31" version="1">MSNSFSECIECENDNFLKCLVETSGSNDENLSIHTIPTLRKQKVSINDRERIIEKTLESYSISVIASMYRINYQTANSIVIRYLKTGLVYVDKRGGDRRSKLTMEIKESLQAYVDLECTKTLYELAEWVKCTFNIDMSTSTIDRALRKFHYNLKRVTLVPERRNTLSKIELRTNYATSFRELEVDNDDKNFVFLDGVGFAVVTRPSRGRNMRGASAYLSVTAARSRNISVVAAMNKYGMIYYKIHERAVNGEDFKLFFKEINESVQRQGILTPIFVMDNAKIHHYRGLNDDEEIVSYRIKYLPPYSHFLNPIENVFSPQLRILIYEKFNEITGEHCSSFYRKMLGYLQKAETIELRTGTNLEPNSTKIRINTTNNKISEEQNRKYNKLEYAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G2</accession>
    <name>A0A4Q9M1G2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0163p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000163">
        <property type="protein sequence ID" value="TBU19957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0163p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="493" mass="58231" checksum="13A4D276348A6F26" modified="2019-07-31" version="1">MDKKTRRRILIIGGIFLFLAIFITYCIFSAKKRSENFQKEYEKFINSKQGALILEKCSGMINIVTTFGVREYFQITPALSVCAKQKNIHGKILDILHSIRISQNNPREYDWAIECFDKLEYINLPYIFDIPKFKKLGQQYKVNIFTNIGLLFYRKNTLFSFFIEYIGNFNKKMINLETGFPMVEQTFDENCVDIEYYSLEYKDKYDFDCSIRYSRIPDRSKQNPLLGFLIFIMYKSHQNRLQEYFLKILDIVGVQLVTMLLTNFENFIKKAYESYEYLFYSIFLNKSSVISESDPILSKRINDIEEHKKVEDFLDFFNIIFETSIRVVFRSYLHIEKYEEEVAKEKLKNLATPIIEMMTNNSIKTRNDEKIGILKEKSVKSLANIFLNLKCWCKQVLEDQKKENKIFKKDAQNNIDGSKGVNEDIAAKLLKKKILENLPSLKEDLETISSYFFIRYKYRKNGVMTDENVMFAILDCLLRNAISSLDILLTVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q1</accession>
    <name>A0A4Q9M1Q1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0040p0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0130"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="28527" checksum="751A42CE015150AD" modified="2019-07-31" version="1" fragment="single">IETESIDRETESIDRETEFIKETESIIEKESLIETESIDRETESIDREKESIDREKESIDRETETINRKINKKYLTETSDLIKICKNEFIKSVWTYLLSYINGDKNKIKLFFFKYKIYELNCNFCILKNSEFFKKLSEILQNKEKFKIEKIKFGVNVVDTLSVWKNLPINFYVFCFYTEVTPNIKVRIGYDNLFIYLDVEPIVNVTLFVACEYVSVCLVIRFKEDLVLSDIKFIKISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T1</accession>
    <name>A0A4Q9M1T1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0268p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000268">
        <property type="protein sequence ID" value="TBU17673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0268p0020"/>
    <dbReference type="OrthoDB" id="2190145at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="29425" checksum="E805A75F7080F689" modified="2019-07-31" version="1">MIKFLLLFYINLNFSKRRNKKHANDYIEESNEEGTLGFNSMSHTPQASDSEYQSEMNELYPKKILYNDSPILSKSEVAQNKINEFDKQTVELNKKLGTSGEITSLSNKEKWNGLFSHFFNNLDKYLINGNLIIVLNIRYSMCVYIIAFIPADFIFFIPASYKKLLPKKAYEIPIFSDGLKEFNKFLQFVKEKSEKEFIITFVLGRQGTAIDDLKMLATLPAKIFSDPMTVLREILAFSIRSEGYEDFKKNYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K1</accession>
    <name>A0A4Q9M2K1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0076p0100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2K1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0100"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="416" mass="49717" checksum="FE812FDFA2EECD45" modified="2019-07-31" version="1">MEGSKILVNKNIKKRKIDGLKNLSIIISFIACIRFMFANYKKHGILITLPLQSLLFKDIQGLFYILIMNFFKCLFAFCNEYYFNNLIFKLIFLLSFEIFIGYSNVKYIQNVYFSLSLLILSVSFLMKTISFHIYFYRILTFGGSNKKFNDAAKKVTHKTCSIENTKTKHFASKYTKLSFSYYLYFICIPTLCFRKKYKIRKNRNWISILNLFLKFLISILLIMFIMDQYAVPCIYNIENSRDIISLIENVLDLSISTTFLWLIFFYSCFYCFLNILARITKYKNDKFYKKWWNVSSIRQFWSCWNIPVHEWFKEVVYIPLVQNNYSKSHASCFIFFLSAILHEYVIGASTKMFKGWIFLSIFSQIFLIKISDYTCCFPNLGNYLFWCSFCIIGQPMCMFLYYRALYLKKIPLEMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Q4</accession>
    <name>A0A4Q9M2Q4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0066p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000066">
        <property type="protein sequence ID" value="TBU20467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Q4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0066p0030"/>
    <dbReference type="OrthoDB" id="8049952at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="85009" checksum="70EB68C40D2DF197" modified="2019-07-31" version="1">MLFFGQLCFNNPLSESIIVENEASTMVPIIDIDPDIVLFEENAGDTQLILEITSDVHEEFTETVTTKTTIIADDFGSDSKIHQPTRGKPQCTYYSKGNRLIVLHSILDSATDVEQVWPGSAILAVQKGYYNEELVVLQEENTQRHRIATFLLDPCFLTDIILYINLRKCLCKEIEDGVVRTRKLQSEYAECHVPKDVSDAARIIQSIQVCYDESTSKESIESKISKILCFIDLLEKTVRQEKVSSSQKKKRITMYKSRKQLGKGNRMFELLRDRFYRGLSERVESEHLISLICLEETPQAGWYYCELTYLIFKGTPRTGSDYRLITCMLNMYKLTKNILLKVFISKLNIYISVRPEKTLSKKIDREILQGDSMSPSLFVLCMDLLSRKLNEKYTKTSLVIDDGRYDEIYAQYRGKLYKEKHCNFLEGICVYKYLGIERIAEKFPKENFATQNNLKKLFFAINQNVKSLINYHIKELRSESSDFSKCDEALYFMLEIGRDLLGMGSNSKEELTLKNFEEAQLEKLYYEIDKRKLHSKLYNVRNNELLRVSDSSGEVESELKAKESWGNASVGVFKRAEMHEEPTLPLKQASNDEECVKHLKTKNIPLVITGRTMYGEPMINISEELDLEEETVGIKSIHLEFNNNSRRMIDSKVCKGMNVSSSFFSDKKIHKYTRRAPDRATSNETDHFLINSRYGSSVMNVQNSRSADIDADHFLVMMKYRQCIVILKIIKNPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Z1</accession>
    <name>A0A4Q9M3Z1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0106p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Z1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="59693" checksum="1A9C837697680626" modified="2019-07-31" version="1">MTDISGSNVFNMTNEEFIKYRKYFLPFLIVLYDSIRLFFNSNTKELLFMVKKTNNKCDLVGINYTKEIAIRITPTALSLIEEDNIKDKQKLLFRLVNSYKIDGIKISSDNNYFVESRNLDIKFEFANDNSDIYEMKASFCSVFCTPKSLRKNEIKSIEFERIFLSVLDISFLYELINLESLILVKCEFIDSNIFFLRLSRNFKNLKVLRIINFNIQNGFFNNLRLKNLEILDLSYCKYKGNCGQLNPEIVKVTKEFIMENSLLNYKIMDSIIINNHLDVLSMKGINFTAVKFFGNCANWNKSFRLLDLSGCILANKFVDFFSTNLKCEMLFLETLYGYKHLNRILSQNSLHTSTWILSISGNVLNSETLINIYKFERLEYLNLSNMPRLDIKGFDFEPCKFKSHLIAINLSKNNLNKECLASIGHFNRLESLNLSECNLEAGFIESLCCNNLLVSLKRMNLTRNKLIRSDMETIEAFVNLIFIIISSDSEEFSDFFINYGRLKCPKLRISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M442</accession>
    <name>A0A4Q9M442_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0060p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M442"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="12308" checksum="E41066C105D52153" modified="2019-07-31" version="1">MEKDIFRMNYSSKEYKGIIVVRNIKEYFTKEYSSKEYKGIYYSKEYKGIIVVRNILVRNIKEYSSKEYKGIIVVRNIVVRNIKEYSSKEYKGIIVVRNIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M450</accession>
    <name>A0A4Q9M450_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0059p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000059">
        <property type="protein sequence ID" value="TBU20512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0059p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="820" mass="95817" checksum="CEFBF88C952125B8" modified="2019-07-31" version="1">MYFDCVLFLLNASFHKKKCKKILQLPISFRNYTFIILICRFLRPNNCIRIVIDFERAGFLENPATEKPLLLSLLNSYSRKKKYGSEIRSLRQFQPSFFASQRHFKVYSNQIEYHAPNAKNILPSESDIIEHNIEGIAVFNNKDFCIENLGDTEILLSEDTDMFSFDYSDDFIIKSKYFDELKRSGNNEIKLNIKDITKSNIDCVIFEECMNILKNGWNLNFAGLKKEEFLGLIWLLYDLTCYSDSDALLTFYKNLLPFIFLYLQDRSNVGVSNLTGADFINYNKYFLPFLYLLYETIDITYNSNRKELVLVEKKQNKNILSFEKHNIDEIMVRITPIALELISQENSKDKFVFLNCIVYSFKIKGIKISSDDIYFTEFKDLDFACNNITKHTTNYEMRTSFISIFSSLQSIKNNEITYVEFERLELLSTDYCFLETLKNLDSLILVKCNTSLNFLLCKLSYYFPKLRKLHIVGFLLLNGFFNHLHALHIELLDLSCCIYNGSSKDLNALRNETLKELRANYSRLNYKILQSFMLCKVLKFLSVRGVNFERLRYFEDHENWQNKFQYLDLSYSKLNQFFSEYFSSNIQVEILYLDQLNEIKYLKRILSQKSLHTTTKKLSLSKNLITRDILTHITAFEVLQHINLSFSTDNSLDFLNSEYVFASKLVDLDLSGNKLELTNLSFIYQFDCLSRLNLCHCDLSYGFMSHLSKALISSLREINLCGNKLCSSDISQIFSITNLVYLVITLDNKVFSEFLKEYGILKCLVLETLVLVNTNVDSDIENFIISQPILKNVELRGCKVNSNSQIMKININPLPLEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M461</accession>
    <name>A0A4Q9M461_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0075p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000075">
        <property type="protein sequence ID" value="TBU20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M461"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M461"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0075p0030"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1092" mass="126120" checksum="135A8A176436F880" modified="2019-07-31" version="1">MDVEWKNLNIELKNKNKSIAKKYVKLVKDAYGEAKAGELCAIMGPSGSGKTTLLKALAGRIPDGGKTTGIVTSNKLERRNRDWINNIAFVDQDDCCYENLTVRQTITYAAKFRLKDKSVKINDKVDTIISNLYLKKIANTRIKSISGGERKRTMIGVELVTDPKIILLDEPTSGLDSSYALDLIRLFREIAEKKLVTIIFTIHQPSYEIFLLFNRLVLLFDGNTVYNSTANEFKTKAESFGFLKREFCSEPEFAIDILKFREEYNEIPENLTNVNEMIKQTLENQEEFKITEPSTSNMFYNGFFPNFYHIFVLLERRFRLYFLGKKSLKYLLYFLCSMILFSLFNVESVYYKWRIFGVNALMNVLIQMDETKKINFAWFLKDNSEPLIKKEFQRIIITLLMINAQLVFSSIFNGSVSHSFMEERDRVKREIGVQSYTTISYFISIFLYHIFVNVLSSILFIVIFKIHFGDFLYNYFYLFSSLSFFGLLPLLLLYGTIANNTAFASILNIVMSICTTVSPQILALIHFYLKEKVKFKGIKVFRMFAFFPFYDLRYIFSIKFLDSIDTNIFSDSKHLPFLQTTLSDLKYILGNFFEIEDISVGFMSSVFFLMTASIIFISIILLNQFLRPEMPKLCATPCDKFPPSSSYTKTTQLPLILTCIKMQNCRFDTLPSPNTPLPSSVKVSMCKPSYDMAKLCTIAIPEGKASNCFFAVQTKFESLPRNSWTDLHMYYNEKFSCAIIGQTRKNPNELVECKVSELINRSITDAAHIVQAAQVCHDEATLTTQTDTVFNSNNKLLFIDNHKLLASDVQTFEEMTEKFSKEKKCIYAQDIKNIYSFHIKNFEEHNLELLELPGKHKDSSTRSVAILKLRKKWEEAQSDKLYKEIKRRKLHSKLNDAKNNELIAKKGSVRPHDEAVFCYIKDRNSFWSAEGMSTRFAKMLVKEILDNEYADPKVEIGIKTDLGLVYRFNVKDNSVSDDLENTFQKDINTNESNGIYTIHCIQEYRTNAEESYASANKRHTTLLKQVCNEEDGVTTKDTKNILTLIFDYIAATAKKLRINSNEESYLEKAVQGLKVRNNYLKVINLIPKNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4A8</accession>
    <name>A0A4Q9M4A8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0067p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000067">
        <property type="protein sequence ID" value="TBU20461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4A8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4A8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0067p0020"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="34"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="7">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="7">
        <location>
            <begin position="219"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="553" mass="62809" checksum="F4B82C9C47A39F59" modified="2019-07-31" version="1">MQCYQSISFKYGIGNKIFNAHCYRETLAMVSTEQPGSVFSDTFLTNTSLVVNALDNIEARLYVDKRCITNKIPLCESGILGTKGNVQVVIPYKTERYSSSRDPPDKNISLCTKRNFPHCIEHTIEWALSEFKSNFEEKIISIIEYIKGVNYRDNKLEGDNDSSSNYRDGDSHKDVEQDPVNDNTDKQHPVNDSTDKQQPLNTIPTNNTPHSTIPTHDNLSTESVAISEDIRVLVNSIPKNIYECVREGVILFNKYFYINIKRLLEKFPVGHVIGDEQPFWVPPKRPPVPFIFNKDDCLHVLFMLEGVNDRGSNIKGVNDMGINGCNIKGVSNHPNKQHPLINRFKEQHPLNNSSNEQHPFIHKPNTGAPNTPSNNNTNNIITLHPVTFKKDNDCNEVSKYTVKGIAVRIIPAIATTTSVISGVFIYRCTDVIEAEKLECEMVRCDSREGGVNDRDRLEGVNDRDRLEGVNNSTNTLHPVNTNTISLLFGIAFMVRIRDTVVFCTFYDNERFKNNLEKLILMAFFTVVYSVCLILMVMTFLRLLLTLGEREGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4I4</accession>
    <name>A0A4Q9M4I4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0066p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000066">
        <property type="protein sequence ID" value="TBU20466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4I4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0066p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="432" mass="52380" checksum="791BE1309C1C3916" modified="2019-07-31" version="1">MKKQILDRLEKEIEIFLKTNNQSVTIDTIYNEVIFKRINVFLKHIINIFMSGYKKDKKRLQFFSFLINEVSSKNDLENMNSKFQYCEDNLPNYRGYLEQNRLTNYFFLSLRSEESCEIKIISTILIQDLKLILQKIFRHFENYQDMLSYFKDNDTDKLKSKYVKKTDKYVFYEVNNTVFDEYFFKHVFDLIFEKTIASNSFLIKYILSYNDEEYINERKFIDETWNLTTENHLFLDAEINPEEIGKNFGSFLRNNIKNTKNSNNYRNRIYILLDVRKSFEAFCQFYIEKMKSQESNDNLVSKIDEDLFMKLHFVSSDFRKLINENFIFLNYICSLIYLTKKNCEIHIFFSDFKQNESENCLKQKYFLVSRYKKFSQDLKSNCNNSDEDESKLLAEINLRFKNEYKMLFEITMRGMLNSKEDFTFDNKIIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JTP7</accession>
    <name>A0A4V2JTP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_2522p0010</name>
        <name evidence="11" type="ORF">CWI38_0446p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002522">
        <property type="protein sequence ID" value="TBT97071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000446">
        <property type="protein sequence ID" value="TBU13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JTP7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JTP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2522p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0446p0020"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036125276" evidence="9">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT97071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="348" mass="40325" checksum="270D45ACADC328B5" modified="2019-07-31" version="1">MKVIPIIILYVFSILVVYASTCQKRNYKEYLNVYNAISLPILASLALFMTYICLKVVKVYFMNVILATIFSFLSFFSLISNFELFYRFAKVKIFGKKPQPIPVNDANTTIVSILYEDQIMINTSCTPLTSFEESNSDQNSGYFLKKYYNNILEWYSNLTFMKLLCISISMMLCLLYVISTHWILINIMTISVMFQTIRNIGLDSTRTGIFILLALFLYDVVWVFSGNVMETVSEKIQIPVKIVVPNEKNTFTIIGLGDLFIPGLFLSMIRNFSIRQKKIGIYWFTLLGYSLGLGIAICFMVLFKKSQPALMYICPLLLLTSFTYSLYLNMFKDFLIYKQNNTFYEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUK4</accession>
    <name>A0A4V2JUK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit H of V-type proton ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0942p0010</name>
        <name evidence="7" type="ORF">CWI38_0381p0010</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000942">
        <property type="protein sequence ID" value="TBU00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000381">
        <property type="protein sequence ID" value="TBU13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUK4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0942p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0381p0010"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="398" mass="47502" checksum="50A2FB035E822E42" modified="2019-07-31" version="1">MLLEKLENKIKMSCSDFNLLENSFTETERLQLEEEKKLDKVSQSLLNTQDCGIIRWLLCTRPKYFIMNSSMVDLLFQYLEMNDKYIVFKSCEILTSYYEDDVPEDNYWKFCKKILLSGKSYEEMKQILYFLAEILYIKKHGLRISDDGKGLFDRNVVKVYFCTDERFMDLIFKFLRVRETQYYVLRICWILSFNKKCIEILDLYNLIENIVLIIKERSKEKILRLCFGIIRNFLEFEYSFGINKTHQILQEVEKFLGKKQTDPEFISDLEFTRSKLNFYLKNSSSINNYFNELFGGKLEEAPYHYTDSFWESNIKILLENKVEIVKALRRYLKSQNSNYICISANDIYHFVKVAPEICSLICKFKLKEDLFLLTSSPNDDVRFYAIQALATCIFSEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVB2</accession>
    <name>A0A4V2JVB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0307p0010</name>
        <name evidence="3" type="ORF">CWI38_0488p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000307">
        <property type="protein sequence ID" value="TBU03362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000488">
        <property type="protein sequence ID" value="TBU13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0307p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0488p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="236" mass="27600" checksum="D355CAF86672A3C0" modified="2019-07-31" version="1">MTEINCTRRRRIIIFIAIVLLATITFFVFCHFEAKRFNQKYLNKVNDYIKSNEEKSVEKFTKVGLLSLVIHAENDLKEGDIFYYENVPEEEKKKDIEHVENIMKGENPSEESIAEEPEYEKFPQDWEKEKFDKLTEIEGNNFFSKLGLCSTLRNAEVNLFLGLHTFLSDRIQDSIPEKDLALYIAMEKNKISVLSSCSDPQRNSFTHFKSIDFELPEDKEEETTKTISYFIFGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX69</accession>
    <name>A0A4V2JX69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1632p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001632">
        <property type="protein sequence ID" value="TBU10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX69"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1632p0010"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10225" checksum="4B2CBD3D08870B7E" modified="2019-07-31" version="1">MAFKKSESIKRCGGILSKNRAMICDKCSTMCCICKDFLSTSYKAYICENCASFSPSCVICGYSIADNTAYYCFQCKTLEKDRDGCPMKHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE6</accession>
    <name>A0A4V2JXE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-class molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1172p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001172">
        <property type="protein sequence ID" value="TBU11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1172p0030"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="46857" checksum="F31293127D880147" modified="2019-07-31" version="1">MDPKGYYNLLGIQPNSSKEEVKKAYNRKQKEYHPDFGTKSKEANQIKDEKIRSQKLKELHDTSVKLNEAKSILFDDEKKKMYDSGITDDHSSFDTSSIFDIFAQFGGRSSRTRQPKKAEDTTVKVCISLKESFTGKETKFKIKKNNICITCKGKGAEDTKTCTRCNGVGKIQSEIRRGIFITIEERECDTCKGERSIPIGNTCITCKGKKYTQSENILEVKIRAGVKEGEKIVFSGMGDEKVNCKTGDIIFIVSVKDSDKNKSLFSRIGDDILAEVKVDLITVLVGGSLYFEHLDGKVLEIFVEKIRNFEECVVLQGEGFLGEKGSRGNLYLKLNYIIPRNFDKEKLLSVIPPTLSRPGKVNGSVKGRYGAVPVQEEEDEGGVLDNKISSNKISSNKISSKISSNKISNNDGISKIIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI4</accession>
    <name>A0A4V2JXI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0968p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000968">
        <property type="protein sequence ID" value="TBU11942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0968p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020585908" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15180" checksum="C40D73DA6FD15BF8" modified="2019-07-31" version="1">MSKLLCVTLFFILKITKGTNEANSECLRNESLQRMINEAIDDNQDFTKDRDTIDIKDVATFEMIDSDTTSFTSTSNEENFVNVLNNIENTKAFFGKNKCGGFFIPGLGFKFIDANSPLFLIHHRISRIRIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP3</accession>
    <name>A0A4V2JXP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0696p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000696">
        <property type="protein sequence ID" value="TBU12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0696p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13351" checksum="2408C3B4A70AC08D" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEENGAKNFKTKYKARFILQGGTTSEEPTNNINEELDLEEETIVVKEVEENTSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTR1</accession>
    <name>A0A4Q9KTR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1865p0020</name>
        <name evidence="3" type="ORF">CWI38_2510p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001865">
        <property type="protein sequence ID" value="TBT98178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002510">
        <property type="protein sequence ID" value="TBU06770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1865p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2510p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="106" mass="12900" checksum="F45EADC36D9C351C" modified="2019-07-31" version="1">MKVSDKNIFIKFTFNVNFIYMSALFFLVENLKAENSFIFHFYNEEEYNLKCDKEHEMPFSKFIKHRYNCFEHKECINCIKHIITGVDKFSLNFDIEDEEKGEYIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3D2</accession>
    <name>A0A4Q9L3D2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0589p0010</name>
        <name evidence="2" type="ORF">CWI38_1499p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000589">
        <property type="protein sequence ID" value="TBU01958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001499">
        <property type="protein sequence ID" value="TBU10875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0589p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1499p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="123" mass="14839" checksum="06EE20944F9E04C8" modified="2019-07-31" version="1">MNNKYESFYSFYIKSVVNTIKEKKFTDQLKYILENKIKIIIIDYCGLILKLYPYFVNIDMEYYYVYDVYKCKKELNELFSYGDIVFVFIDFTINKMCGNSDMCECGYCRKYSDNVLIFSNLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6N4</accession>
    <name>A0A4Q9L6N4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0384p0020</name>
        <name evidence="12" type="ORF">CWI38_0911p0030</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000384">
        <property type="protein sequence ID" value="TBU02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000911">
        <property type="protein sequence ID" value="TBU12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6N4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L6N4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0384p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0911p0030"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="51"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="346"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="584" mass="66799" checksum="ECED85DC7D697F12" modified="2019-07-31" version="1">MQKEEKSDWQVIKEVFQKYVLAIPTIKLMIIPTFACVLISKFLEVHLGESLQDFSKKMAGNLEETSFNFLLLRFMITMCFLNMFSLLQGYIFAGPIQKSFRLAAKSTFKKYMSLSHTNFHALGSGEIHSSIERKSKAVADILDVIVLHIFPVVSIIVFSGFKIFFSLGKFPAIMLFVALVLYALITIRITKYRNKIRKLLNISVNDSSNLLYDRLINFDIILAYNNQELELQKYDDSLKPIQTHSTRLMKALHILNFVQRMVFSFINVLVIYCGINGILMDKITSDSLILYITISKTLSSNLSKLGYIYHRYTQAITDAKMTHENFFEISSQKALKYDLGKFENEIKFKEINFFRGSRMILNNISFTIFKGEKVAIAGKNGSGKSTLIKILLGFHEFQGKIFIDNTDFNSININSLRKIIGYVPQDGNILNESIKYNMQYGDFEAKNDRIVEVSDDFHIHDSIMKIDNSYLAVAGERGEKLSGGEKQKVALVRAVLKNPDILILDEPTASLDKESETDILNVLLSQYSDKTLIMIIHNIGLLKSFDKVVFLSPNFGIEVGSHSELLERKGEYYNFYMQKILTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD01</accession>
    <name>A0A4Q9LD01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0282p0030</name>
        <name evidence="4" type="ORF">CWI38_0294p0050</name>
        <name evidence="3" type="ORF">CWI38_2700p0010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000282">
        <property type="protein sequence ID" value="TBU03520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002700">
        <property type="protein sequence ID" value="TBU05819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0282p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2700p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445350" evidence="1">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="169" mass="20266" checksum="087938131903E1F8" modified="2019-07-31" version="1">MLVFLFFCSLIHSSNRKYIWEKNAKLLERRQSKPIGIKYYKLKDDENEAKITREICPMFPPLVFSSKEPHITKKILETSIYHLRRKYSNLKVRFYIKLAELVIHESYLERLHPLMTNIETKTINIMKLFARIDDYTDKIVLRICYDMICSCNRAITIFAKNIEILASYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFP9</accession>
    <name>A0A4Q9LFP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2493p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002493">
        <property type="protein sequence ID" value="TBU06869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2493p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="588" mass="67260" checksum="4D2F552B3264245F" modified="2019-07-31" version="1" fragment="single">KTRCTSKKQTKRNNELNTAEVLRTVQAVKPRVRGRDLGDTPHEQTVSLNSKNLTTCQKRNTIIHPKADSSSFLSDHTNNTQDNIFQKSRAGKNVLPSVIEKAHLKKGKDTTQITHMNNKLTSSSNKLTRKILSRLRIKVLIRTVPKQNTLRGGTDKPYRKRSLETTNSEIGEDQVKKINYQADIKETISDKSESSPIKLTAEHLAHLTQGKSPFTYARHLVVNMEFLSNTVLEVICKGIFRMLGAKHLINSPEVDSNGLFKISKLFTRMKKIKDRQGNKNDKLRIGYINVGGLSDNRIFKINNLIQGHMLDILGVAETWRDNITPLLRGYKVLNSKKSVQVRDRYSNKEGIIVLGRDTIVSEAIDNITDEGVSIKVNDQIFIFIYRPPKSTEFNIVKPTLNQYLYKRLYILGEYNLEQHKTLEQQILDNHAMYGLSEIDILTNTYKHNNKESKPDKIFTNTIVDIKISTIVDKSQTLDIKTDRNTKKRKLTNITNKIEILIKKNANIMRTLNINDCCAALHNIILSGVYKPRIRKNSPLERARHNNPILFERLCKEVKRLTKNLPDTDTRDLKVEHIGLEASQLEAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFW2</accession>
    <name>A0A4Q9LFW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2554p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002554">
        <property type="protein sequence ID" value="TBU06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2554p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="29573" checksum="22518AFD3DAFD257" modified="2019-07-31" version="1" fragment="single">MIQKKIFSEILIFINLLEVEKPAFNDFISYVSNEESNRYGCFSNFNKRKRKGVFLKGLCKETRKIVRKRISVHHLNPLNLKTNEFGTEVKQEIQIYLPHITASDFDLFCKMLQFYCDPLDYLPLETFFKFLNILSCLNLVLDKNLDKILLNLLISVRFPLENDIYELKPTILQYIETYTISSDIVTTMGKLFKNLSLFKIGFELILFLNTTNEKMYHYYNVKFETKSAILISKNLKKIFSNQNFKNTLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH49</accession>
    <name>A0A4Q9LH49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2564p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002564">
        <property type="protein sequence ID" value="TBU06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2564p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="685" mass="76230" checksum="581EE16DD724FD5C" modified="2019-07-31" version="1" fragment="single">GNNTPLNNSSVNNTPLNKSTVNTPLNNSSGNNTPLNNSSVNNTPLNKSTVNTPLNNSSGNNTPLNNSSVNTPLNKSSINTPLNNSSVNTPLNKSTVINTPLNKSSINNTPLNKSSINTPLTTHSNNTLFYILIYPLYYLYNSTPYPLTFSIINTSLNCCTLLTLSPNNNVSLPYFHINNTAYISTIQQDNKSNILTHDKYYINNNITYGLYYDKKVLNIKGNKIYSLITEITVYPLFICNNYLKVEVSIGGNSIRGVSNSSNDYRGVSNSRDMVSSVKGVSNIVDIQQGVKDNTYDNTYDNTYDNTYDNTACFNLEDRKCSVRCMGLSSDRLDFGVPEMLCILSVGKSKSRERVMEYERVFNIGKGDKGNKDIKGVSNIVDIQQGVKDKGTNIKGVNSSIDDYKGVSNSTSKQQGVNISTIKQQGVNNLSNEQQGVNISTDVQQGVNNNNISTNKQHPLNNNHLNNNNTNINNTPLTDLLPLNNRLYLTPCYLSLSIEMVPGKGKYCKSRIINIRYSNILKNNTCYSLIIISENYVMDIGCYSSKEIHLYKNNGFYILFRKKVNNTLLSSYCSYVSVKPVSDYIRIEGVLFKVEVTLENKQRVLSIIEVYNYPYYIVNCSKSVIYYKQCGSKEEYTGCYNYSEGGYSNDGYRGVSNSNDGYRGVSNSNDGYRGVSNSNDGYRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH91</accession>
    <name>A0A4Q9LH91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2595p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002595">
        <property type="protein sequence ID" value="TBU06340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH91"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LH91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2595p0020"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU06340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26452" checksum="85DD70D12A73D15E" modified="2019-07-31" version="1" fragment="single">MATYICLFSYGFSVFIIFMGFKESIDLLFYEEDGSFFPYTGNLLRVFMGAPLIPITMIYTSYVKFSFTFHILPSLIILNYSKMNFSNAATSLLPLTFFIYKKIINNLKNKLKSIYRTGTGNTYQSEIVFNNQVIPLKAVMSCLISPYMASFLGYLFFNQKFIGIEQSLMGGVLYVGIKDLLSITYLIFLKRRSKNIKIIDQGGDEIKENTGDGFEDNNNSFNGEILIEGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHY4</accession>
    <name>A0A4Q9LHY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2378p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002378">
        <property type="protein sequence ID" value="TBU07597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2378p0010"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="906" mass="103223" checksum="4D7C43355B1A0516" modified="2019-07-31" version="1" fragment="single">NNLSNEQHPFNNTTNTLYPFSNTSNEQHPVNNTTNTLYPFSNSTNEQHPVNNLSNEQHPFNNTTNTLYPFSNTSNEQHPVNNTTNTLYPFSNSTNEQHPVNNLSNEQHPFNNTTNTLYPLNNLSNEQHPVNNISTHSYIKVSNYKDIPVNTIECLNKIIKRVLNKEEYLISFINRNKEYNLYNYIIKYSSFNIINKRCCYSKINKILTEYYKGSKEEGVNSSRIELEGVNNSRVVLEGVNNSRVELEGDNYKYSSVKGVNNKYSSVKGVNNKDSKEEGVNDISIEQHPFNDSSIEQHPLNNTTTQHPLIHTLYNLHPLLQIHRASLLSIQLDPLFFTYENIQHNLYFSLKVFPITYFYKNINKFTNPLLTLLLSPTPFILQEIYNGYKGDNTSRLEEEGVIDKEYGLEGDIDKEYGLQGVIDKGSKQQGVNDSTNTLHPFNNSTNYHPSSTITSTVILNTFTSILYMSPLNINNTLEWLLSTFNTSTLLNIYEILLTAYEECNNYKDKGIVESFRDKCKCSVCSNKDSSMLEGVNIRSTNYKGVSDKSMIEGVNIRSTNYKGASDKSMIEGVNIRSTNYKGFSDKDSNYKGVNTSSNYKGFNTSTDTLHPLNNSTNTLHPLNNSTNTLNPLNDSNSNYKGVSNSTDIINPLNTITTYIPFTGIKEFSNNNIYTLITFIYKNIIITPYLDKLFITLYSRIYNYTYKVYIPKNIKYILRVYKGSSNSSNKTPLDKGINKTPLDKGSDTNTPLDNSSNTNTPLLTSKKINTPLVNSTNTNTPLLNSTNTNTPTTNNLIPFISHIITYLDTNTIITLLINYIYKLKVNPCNCYEDLYFYFNKYFYKNIKRYPLSSNKYKEIKGLYYIVKGYIENNIDVSDNRDGDNRVSDSSVSDNRVGDIGDSVSDIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJB8</accession>
    <name>A0A4Q9LJB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2328p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002328">
        <property type="protein sequence ID" value="TBU07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2328p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="23889" checksum="C83A94C0077D518A" modified="2019-07-31" version="1">MNIGNYNRKLLYVITIIGTFDYVFGASNSQCWAKKKYYGRKSSSSSSDDSKCCKSRSCSGHKIQEKRIPCHSRHLSFDEACRNHLKKPFLLDEREHVHSEFSCGFKEPGVSVCRSKGDTGKRLKNLNERVKLENIRLDNCKDRITNIRNIKIKSKCVKNIQKIGNSIRALSHSIRADGLNSSDIFDLDLEADSIESSILGLENYLTIHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJR3</accession>
    <name>A0A4Q9LJR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2284p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002284">
        <property type="protein sequence ID" value="TBU08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2284p0010"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="30058" checksum="2D834DF55FE6EC0D" modified="2019-07-31" version="1" fragment="single">FNFSDVKVGKEPKIAILTPKDKKLKTKIEPNLTSKYLRFLVFNHQEVKAFFNDEKLELEKENNLFTAILPSNIGKIKIIASNSYGNSFKEIDIDSSNHSTYSSFPLNINFLIISIFFLFSYFFVLVFLTLKKKNLECIIRCLFYFLLPCALGKFTKNTWSILYNFYVYPNHYFFDTVLYFTTILFLQEIPYMLYLLGYFSVLPYLIVCIFHSKIMLYFHFGIVFSIFDLFSLPVFYKYFKSKIFKKSVITTNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJU7</accession>
    <name>A0A4Q9LJU7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2279p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002279">
        <property type="protein sequence ID" value="TBU08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJU7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2279p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="535" mass="59723" checksum="F19F1DFF6868EC1F" modified="2019-07-31" version="1">MGVNNKDMLEGVNNKDKLEGVNNKDMLEGKGVNNKDMLEGKGVNNNNYNPLTYPSKYHPLTYPSKYHPLTYPKTPSLSHTEWQHPWSLISPLSHNTLILDYFYYEGLYDMYHTFALETNLIPKNDKLFKDRDMLRKCLERGCVDEAIQRINDIDSSILDSSVDMYYSLMQHKAAEYINECHLCGIVVGDNRVEGGVSNSRIEGGDNNSRIEGGISNSRIEGGDNKESNDYKGVRDSSRIEGGDNKESNNYKGISSSRIEGGVSKESNDYKGISSSRIEGGDNNESNDYKGASNSSNNQDPVNNITNNLHLVINSTYEQDPVNNSTNTLHPVNNSTIEQDPVNNSTNTLHPLNKSTNEQDPVNNSTNTLHPVNDSRNNLHPVSNSSNKQDPVSNTTYEQDPVSNSTNTLHPLSTNTLSTNTISTTNNTSLKDYNLHFKDDLVDKALNFIQSELAPIVESNSGLVSNLEDLMEYFVFGEGDSIEMRRRRVGGYVNGVLMSIYDGNSSELKEVLKGIVVGESKLSRKYKFPSFRSYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM80</accession>
    <name>A0A4Q9LM80_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2194p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002194">
        <property type="protein sequence ID" value="TBU09016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM80"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LM80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2194p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="7">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU09016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="20794" checksum="67AD6C93126A8B09" modified="2019-07-31" version="1" fragment="single">EIEDDRVLNVERCEDDKNLVVESTESKGFENQNVFMTNGSKTKNTIEKSSNTTFFSSGSPDSKDSSLIFYKRTPVDSLYKSVIDKQIRNSSAFRNSIRFDLNSYKPKTVVPVVKLNDEEDLLDNFKLPEWAKDTNLNGIVKQQSHIDLEKYFYYLEDLDVKKIFPYCSTATNESPNKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP94</accession>
    <name>A0A4Q9LP94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1921p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001921">
        <property type="protein sequence ID" value="TBU10238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP94"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1921p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="25701" checksum="1D6014F6B70F4D98" modified="2019-07-31" version="1">MSLLASILSIIISLTLFSITDLFGDCSVIWLWYFVFPIGILLIAHAVCLFIRVEKIHIVHIFITICVLILAILSFFFRTTKETFYSETSLTLDDLSNDFKGFKQESTIYLIVSGEPVSDTDTKATIKKDEIKKVIKKMYEDLVKTGKEKNNVIMHQAFEDPSVIKNKGDATLILDLINSLKFTRIKKGGIISICANGVPQMIKDKKQGQDYDKLKNIIEEKIKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPK1</accession>
    <name>A0A4Q9LPK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1787p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001787">
        <property type="protein sequence ID" value="TBU10403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1787p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12951" checksum="FA9DA140EDF7FD4F" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINKESDLEEETKVVKEVKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPK2</accession>
    <name>A0A4Q9LPK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1885p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001885">
        <property type="protein sequence ID" value="TBU10274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1885p0030"/>
    <dbReference type="OrthoDB" id="2195422at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="728" mass="85279" checksum="39FA09BAD4EE6563" modified="2019-07-31" version="1">MDNKERTEDFITNKSLQTTGNDTIASIKLSYASPDIRTFTDLNLKRSFDKIIEFLQILPKKPNTDCFLCQQLSNQSTEYTVYELIKDYSKAIFCISQHTEKTKDTPQLPKSLILHSIFLEFSVLNEIAEFPLSVQEILNESLNTTFNTSMRDQLVATSKSFVLDTSINIYCEQDIESLTYKIYKKAHIYSETTYTPKNTTLTHFETDLILFLLAKRKETSRFFKIFETTEKSLFRYKLALILTLNGDSEKTSEQLIKETERQNFIFKRNCFCKKCIYCETEDIQNFYSKTNTEYLSEILNNKETEVKEFRDRETLQYTKDREGRDRVDRDRLDRENRLDKHREGKHISAKHRGGKYSNYIRDTSMDKQNNTPHFSVSNWFETLNSYYDWLECIRIWNLNRDIEENVDTSMLDVCLKSQKFEEGWIIWETKKPGTDLCIVKICLLCVRALKNYKDCRECKECNRESVEFENSYEKFENEEYKDKSNNSDTNMSNNSDTNMSNNSDTNSKSNTNSNSSITNTNNTTNNNNITNIYYSDKWVVRLAEVLRYVAAGHMKDTCCIITMDILSEIVDMEEGKRLLVLNLILEILCDGSEIKYDDEIVHVLMKGLLLLCVNCNDSKVTCEVCLSYADRVYNHWHKSRERGFFKIFFKPKMTCLSNKIFCDMLSLCECVKETGCFKKVLKDLIKGNEEINKDLCCRVEKYHRSRQCKCGLGVNDGKKLIKHVISEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU4</accession>
    <name>A0A4Q9LPU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2052p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002052">
        <property type="protein sequence ID" value="TBU10066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2052p0010"/>
    <dbReference type="OrthoDB" id="7697409at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="398"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="690" mass="79059" checksum="BD8BD0353A82A9EB" modified="2019-07-31" version="1" fragment="single">MGRKKNFSSKISKNTKIRAVNDADEVKKSDSGKQKFPSSVKDYACKPSYDMTNLCTQAISESNRLMALQTIFDSVTANPKERHRIVFFWHTDKLNMYYNEKFSCTLDIDAIERRRIATCLTEQCTLTDTTDKIKEISERQIGKVVVRTRKLPNELVDSKILNLINRKIGEYADSCLPMTRTAVARIIQAAQLGFDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKTNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYHGLSERVKSEHVVSRDETVSFWSTMWNKNDDTVTYDDYLIPFGSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIEKLTTLHKYIYDIVKVICLEGTTQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCATKVVQFEGAKEQALLNIAWNKDYGNNLKATWIDVIISKWKIDISVGPEKIMTKKIDRGILQGDSLSPLFFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ61</accession>
    <name>A0A4Q9LQ61_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_1957p0020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="PITK01001957">
        <property type="protein sequence ID" value="TBU10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ61"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1957p0020"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="47341" checksum="0C2C91F82DDF3977" modified="2019-07-31" version="1">MNTKIIHKKDYDFSKTKEYFKDVVILPTETVYGIAADIYNINAIQRIYEVKNRPHDNPLIVHISSLKMLDSLIEGPINIFNSKLIEKYWPGPLTLIFEAKKTLSHILTNNMSTVAIRMPDCEFTLNVIEHLGHPIVMPSANLSGRPSTTSASHVFDDLNGKVPLIIDGDECLLGIESTVVNCLSHVPTILRPGSITYEEICNTLQHKVEICTSLKNKPQQILPNISNNHSITTNESENTENRLNMEFENKDSSAYLSPGMKYKHYSPEKPLYLIKQNGNLINEIIISKVRENKNIIGCIVNTMNVFTKQTLETFKLIEIDDEEYHKKIYNEEIRNNILHEENMEEIKCNKSESPVIYVFCYKNDKKLFAEKLFKYLRFYDKMCDCIIAIGTEYTEEGLAVMDRLEKASTEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ64</accession>
    <name>A0A4Q9LQ64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1669p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001669">
        <property type="protein sequence ID" value="TBU10578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1669p0010"/>
    <dbReference type="OrthoDB" id="277458at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22602" checksum="6F1AE08A2F56D26F" modified="2019-07-31" version="1" fragment="single">MLGVYFPISLFLLSYILYSSYSNHFLGLEKIENLTINKIDAKISECNIKIKSEKLLLIAEENSMWLSIERNKFITIENSGEYNKIFIFKLIIYIDKLLKINKKIIFLLEFLNKKSETMNIKNLISYLENNQIYNNEYLKETNQNIKSIIVSIKNLNLQLLNEFTEISKNVNTHDKKEYDKKHTKNSIYIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ85</accession>
    <name>A0A4Q9LQ85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rcd1-like cell differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1708p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001708">
        <property type="protein sequence ID" value="TBU10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ85"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1708p0020"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28115" checksum="76DDB5A38699BAD1" modified="2019-07-31" version="1" fragment="single">MEQEDISTLCYKLITQKERTLLLRKICKILDTSPNNCQTFWKYQHVPLILLDEIVRTYYTLNTQKFTSEECSRICTVLNIMQRILYCKDIRNSMFETHMPFYLYPFLNLSDNTQKYECLRIASLGVIGSLLQDDSEVAVNYLKNTELIPLTLRIMDIGSEVSKVVATHIFLKIINNKEGLEYACQTFERFVAISVILNSMVYQCISIPSIRLLKGVLECYIRLTFKGNVKVSLFSKKPEALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQI1</accession>
    <name>A0A4Q9LQI1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1548p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001548">
        <property type="protein sequence ID" value="TBU10793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1548p0020"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17838" checksum="253D8278695909C4" modified="2019-07-31" version="1" fragment="single">MKRPYQEETVIEDKSTRTVLITNLENAEQIKPFYKDLPVKEVYTIKENQNILFIIFYDLRNAELFFQRCSTLPFPAVPIYTVSKYEIPRESDKCDEGKNQSTILITNKDNNTLSEEEVSKMCSIFGEIKAVREYRHNQKFVEFYDSRSALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM2</accession>
    <name>A0A4Q9LQM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1560p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001560">
        <property type="protein sequence ID" value="TBU10768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1560p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="16377" checksum="4FBB31CDCBB6A010" modified="2019-07-31" version="1">MTYKRRIKEGYKRRVEEGEYISRLKRGGVEGYKRKDIRDIRDINRLKRGIRDIRDINRLRRGGVEGGIRDIRDINRLKRDIRDINRLRRGYKRKDIRDIIRLKRGIRDINRLRRGVEGGIRDIRDINRNITRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE1</accession>
    <name>A0A4Q9LRE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1403p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001403">
        <property type="protein sequence ID" value="TBU11068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1403p0010"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28932" checksum="541C846A7DA7527D" modified="2019-07-31" version="1" fragment="single">MIKKLDLQENDLGFADLDFIVKLEYLEVLNLQNCKIGLNELVIFSNAKSHLSLLELNLGYNILSASDILAINCFSTMRFLDLRNTKLAEGKFSFLRCEQLKKCLSVLILAQNNLDYEDVYNLSTFENLRKLDLSYSIRKPDLIYLFKNSCISKSLEFLDLSFCKLNANDILGILKCRNLLFLILKCCNLKYGCFSCYDELFLDLKIQLLSLKRNNISSKDLKNIFKIPTIRFLCISHCNLPKNALDIAEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU0</accession>
    <name>A0A4Q9LRU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1314p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001314">
        <property type="protein sequence ID" value="TBU11229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRU0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1314p0040"/>
    <dbReference type="OrthoDB" id="2188018at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="194"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="47367" checksum="EE47E5B9551E4345" modified="2019-07-31" version="1">MIGKIKNSRNIKKINISEVTKNQGLESSELIGILNKIDECKQDINDMGNIHKSIFRIIKNLKLKEKEEESIKTKEDLEKAEISFLENPAIIIHEINIWNHEDKRLPMLKYHMEYKFPIMIYKKNEIYFRSKLVNEPSRDQKKEIPCKKLEKRETKANETIKYDSLSDIEKITLACFCFKKLRKYRSSFKDNILEKISDIFRSSFKKDSYHIKKANTFVYTVGDHIMDVGIKKEGLFRISGKYTYYKFMPGVLAAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQIAERVMKIIKNQTDPSIIEYIVPLIIFSITNENRKMLMYLQKIFRKVDQYSKDNKMGSDNLYKIFTPTIFPNIEYYDLQSINLQIKIVKRIFESNLTEIPCFLYEEAFSVAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS33</accession>
    <name>A0A4Q9LS33_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1483p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001483">
        <property type="protein sequence ID" value="TBU10906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1483p0010"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="42646" checksum="C2963E6B8131643C" modified="2019-07-31" version="1" fragment="single">MISYVMAWNAIVTKYHNSYLKRLQIPITLEKTVETIFFDRRGGPESRPKRQSIRGTNIPLKKWIYKEDGVNHIQTKNNTSLILDREPTIIINEKSNMRKKRWWYKRYKKMHKSKKTILPFKNEIVDIILDSNGYAYKNQITAVISYDDEEIQSFMALLSGEIENNEWTKGIIKADGTYREDNDWIKNFIFCKNTNVFLPYITVNDAIKFCFLFKGNHISSLEEIEETLKLFKLFRIRNNKIEQLSESETNRLFLARIYILEQKVVFISNVFKSSLSNKRSRNLFCKILRQVSKTKTVFLGLNKFHREIYSIIDSIVILNKGRTVFSGTKKSYIEFLKKYNIELSGKKFRNLEFLSQLSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD0</accession>
    <name>A0A4Q9LSD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1191p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001191">
        <property type="protein sequence ID" value="TBU11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1191p0030"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="10451" checksum="081FE9C95CB3953E" modified="2019-07-31" version="1" fragment="single">IGFFIDSFGHTIQRNIIFSWHCIPTDFKMFENYLVCLSSDHLSIWDVTNANIVFVKYIRGLRFVEGTTKPLLHDKRSLYLLTLPSKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF5</accession>
    <name>A0A4Q9LSF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1229p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001229">
        <property type="protein sequence ID" value="TBU11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1229p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="48007" checksum="DF8BBB2BE9F29DE8" modified="2019-07-31" version="1">MKINIFYEFENLKHEFLVPVFKEVSSTFYSLNEIYLQSGEELSFHKYKNSSQNINILVTTSLEQYLSINEYKIFIRQEDEEECKKMRDKAEDSVEEDNKITANEVEEISVHKNNILSQYINEINFISSDYKNYKQILSDFVLSCIKIQQIDLSNIYVKNKEGIKMNPEFHIYVEKKPLIKLENKLAHLSNLKQTKDNKRFEYSMINENFLICKILDPILKSLLKFYDLKFIDSNQITYDLTYQLNEYFIVPSSNHSIFSSLICQNLYKFDELNLFIKYCDSSKSKYSHQIKTAFCCKLMDLEINAKFNRTLKAIERKGNLDDFNLGLNTLEILPNFFDHRKVFYEKLKNLFEILNKKYSKLFYDDKLINKSQLKTEYLPLGQYRNIDRQPVMSLKRFYYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ5</accession>
    <name>A0A4Q9LSJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1389p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001389">
        <property type="protein sequence ID" value="TBU11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1389p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="8902" checksum="E8FACF8ABF352A66" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISSKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM3</accession>
    <name>A0A4Q9LSM3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1370p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001370">
        <property type="protein sequence ID" value="TBU11126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1370p0020"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33677" checksum="A51C42C455641482" modified="2019-07-31" version="1">MKINDAPFDSISDIKFNKNLLVTSWDKIIRLYDINENKQIMKLTTEYPILKGIFKSDTECVIGDVKGNINFIDIERQLLTNNICVDRGIQCLYKHNSAFLCGGWSKKIYFFDDQKVFLEKNLPEKIVCSDIKDDKIIIGMNNRVSIYDIRNFNNPIKDTEYKDTIIRSISFGIKDIDYCFGTVNGKIRIEFSNQKNNFSFNSNYQPNNNFKLMYPINHIEFNEDRLIVGGSDGLISEIDVYKKKRTKTIFKGNTGISCFVIDYDKIIIGCSYLYEKGNIEHPPSSIHVVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT15</accession>
    <name>A0A4Q9LT15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1061p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001061">
        <property type="protein sequence ID" value="TBU11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT15"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1061p0030"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="52"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="233"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="704" mass="83139" checksum="634DE03BEB599BA6" modified="2019-07-31" version="1" fragment="single">DLNYRKLNGKNEDFSDEFTINKFENQLFSNETKEITSKENDLPIFEKKYEIINAIKRNSVVIIEGSTGCGKTTQLPQFLLPYYNKIVCTQPRRIAAISVAKSVSQQLRTHLGELVGYKIRFKNVTSRKTRIKFVTEGILLREIKNKRFLENDIIILDETHERSLNIDLLISYFRNNQSSKIKLIIMSATLNSYKFSRFFNDCPIIQIFAQRFPIQTNFLKYSCENHINETAKTIIEIHKNTKDGDILAFLTGKNEIDDVFVYLNTELNNIAMEKDSQPIIFKLYSGISKEYQQNVFEKYDRRKIILSTNIAETSITIPDLTYVIDCGFFKQKKYYKCDILETVKISKAQAIQRSGRVGRCKEGFVYRLYTENEYNEFLDEPIPESLRCDFSEVIISLLWLGIRNIFEFEMIDKPINEKIFKALEELYWLNGIEELNQDSRDLYKKGEPQIKLTDTGNKMAEIPLNIKYSKILIIGELLGVFEEVLIICCMLNVQNIYEEIRKNDKNFAIFLKVKENFSDEKGDHFSYLKIYKKWAMTDFSREFCKTNFLNYFSLKNVQKMIDQIKNQFLKFHKNHNFDYEKTDKIKRCYGKDELIIYSISCGFFRNVCKRSNFSYTTLDDKNEYFIHPSSVLYSETPDLIIYLDIITSKKQYVINCLKITPDILFKSSNNFYCISNEIKPLFNNRKEDQNYLKKPKIVYNRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT92</accession>
    <name>A0A4Q9LT92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1457p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001457">
        <property type="protein sequence ID" value="TBU10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1457p0010"/>
    <dbReference type="OrthoDB" id="2191533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8995" checksum="4BA0CF7C9FBF7F7A" modified="2019-07-31" version="1">MLVIILGVLYLEGGRCSYRRMVVVLKDTINFEKFISIFRKKGYLKVYKEDGEVMIEYGWRFHLEFPSFSIDEVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI8</accession>
    <name>A0A4Q9LTI8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1030p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001030">
        <property type="protein sequence ID" value="TBU11814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1030p0050"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12807" checksum="30C1124FE2A9E4E1" modified="2019-07-31" version="1">MFCMCGTLLQIKKEGETVICKKCGKSVKINKIEPFIIEKVFNNEEVVNTRNKVKGAKIKERCPSCDSNEMFYNVIQLRSVDEGQTVFYEGVKIESSGYMGVNIKTRGVIIKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM2</accession>
    <name>A0A4Q9LTM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1480p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001480">
        <property type="protein sequence ID" value="TBU10910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1480p0010"/>
    <dbReference type="OrthoDB" id="2201196at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021022963" evidence="3">
        <location>
            <begin position="20"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="703" mass="79261" checksum="336D9232A3B6E23D" modified="2019-07-31" version="1">MKMCIILLIMVLKCQIVIIDDIGMKGNTGEEYNGSLFKENLPLNDTLSKLYDNGRGVNDTYKGNTPLGDMGPFSGGNKTPYSGNNPLSDTGPFSGSNNTPYSGNNPLGDMGPFSGGNMTPYSGNNPLDYLKNYKGVLDNSGDDKGAKPPYMGNTLLGDPGLFKIPSNSNNIPYKANTPLSDPGKPNFNKNTSKNKKPMENKPKYSPQSDDLQQIPIYSFQDIFNMKNKLNNGFSKNSNSNQNTEKDRDNSIDRDNNRDRDKGNVRDESRDRDKGNEKDKDRDKERKDNASNTDGKDNSNLNILENREPSYKSKNVENGNIKPKSSNSTDNSYNHKGNNTNISVLDISDTKVVKDNDENTDLEIYKKFKKPIINTPSPIDISNEDYLGNIGNEESKPSLNKEISYNEGNGNNTGVGNSRDIRPKESNSTISYTINVNEGGSDVPKHENIPDMPSITHPYLSVDSLTPIHPYVPPSDSGSHPYLSANIDTLPNSDIFTQKKLMDKEKSNLKDANVARSSFLQLKYDESKNRLDSLKNSLNDLTSKLSILQEKMKERGMENDNLKETLRNNRNHLKNSKTNLGKIAHEKHKIEAELRLDNNEIAKLNKKIDDLRNKVETLKAEQNVYRERGLTLDREVLQTDKNIKIEESKTREYKKELESLQVLLNSLNERRSELVGKMSNEESLQSKIWMEMDRIRRSELSYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV4</accession>
    <name>A0A4Q9LTV4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0919p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000919">
        <property type="protein sequence ID" value="TBU12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0919p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="74718" checksum="F67418C61BBD423D" modified="2019-07-31" version="1">MPQEISDIFIYKESLLKSNILGSTIFKSYFVTLTNTSINFYSLIDFTKIITFPLIKNIENKNSFISSDNEILISSEDLNFIYKMIKIDLKYKLGNVFTQCSFTDRFFITAVDNTDIFFYDKFSDFKEELIYKSKNNSISSLKAISDEIIIGTNDGKIIILNFKFDSNQNDNKLAITNNKMLKVDEEYVITGIEHIEYNYYCCVSSSGRAFFFDTKLCSILQTITVSKGPLRCLVTGNDFIYISGDYTGINAYSRVFDYYESTENSKIRKYRFFAKIDTHYLPITNLIYNNERIISVSQDGLINLHWLCEDKFLFRKYYFGKKICFYKKYFTVQNNKKINFYKFLLPNKVQNNKKTEFNLINLSNKNIRFDVKFKSKSNIIDYSYYKKYLVISQNDKSKLYKLKDKKFKKVKSFLPGYQVSFSENLLVINTFNGYIIVYCLKSKKEICRIILDEYEKVLYVENEYVVTKSKIYFINQELSENSKKIKNNENINYICDYSSLLDKEYEMDLFFNHKNYKIIIYHLKNYSYETKYYISIIKSTKIKNDEIFKLELKNIYKIDGGFYTENGVYFYNHSYLFYCRIYDDRIDEFKRIYVGEILEGITIINNQVVGIKSSYTKIFEGIKEKYGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU32</accession>
    <name>A0A4Q9LU32_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1077p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001077">
        <property type="protein sequence ID" value="TBU11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU32"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1077p0010"/>
    <dbReference type="OrthoDB" id="2196203at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="37785" checksum="2B3E565DD657964D" modified="2019-07-31" version="1" fragment="single">DKQQGVSNSTDKQYPVNNTTYEQHPVINSTFVDSDSLITNSVNTTLLENNNNINNTPLDNTWDYLTLLCVIDFPLNMIINKKTILRFSTIFKFLWKVKKVERILGSLKKRKLDKNSLNRIHFYYCFVQSFMFYCCEEVISIEWSCFLRLECFEENLYENKSKNCRYTNVEGGGVNDRGNLEEGVNDRGSCIKGVNYRDSAQQGVSKNIDKQHPFNNSIHQQHPFNDIYHNPSINNSTLMNSRLIESFKDGLLDLTGKIIERGYMTGRMKEKLFLFFSELEALSVKVGRTGQPFDDFGVKKCLREFYIELGSRVENTGLFIYKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU66</accession>
    <name>A0A4Q9LU66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDP dissociation inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1380p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001380">
        <property type="protein sequence ID" value="TBU11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU66"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1380p0010"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="899" mass="99390" checksum="283CA164187F3899" modified="2019-07-31" version="1">MEEKYDFIILGTGLTECILAQILSLKGYTVLHIDKNSSYGSETRTLRISELEEKIQGTLFSSSKCDSSKCDSSNNLCDRCDTSSKCDTNNLYSTNNTNITTNNTNITTNNLYSNTNTNNSNTNTNNSTNTNNSNTNTNSNNLYSTNNTNTNNHHTNTSLLSLDKHFSIDLTPKLLLSDGYMKKLLSKFDINNTVSFTHIPHSYIYINQCIYEVPTNERKSFESSVISLWQKPRVIQFFWNVRKYSEMRNGSRGVGVGVGGSGVGGGNSSSRVGGGSNNSSSNNSSSNNSTNNTNITNISNRVVNSSPCINTSNTNSNNTNSSNDNDFISNISNISISSNKDISNTKDTKDNISNISISNNTNNPNPTNTNNNNNTKNTNNTNNNPLNTKPFLFHGSTMKEQFEYFKLNTSSSDFIGHAIALNLDDNYLYKHPIETYDKIYTYVKSCTCYSSNSPYIYPLYGLSELSQAFCRKAAIQGTVYRLNTEIVGNMFGGGGEGDKGDSNGGDSNIDSNRGDGNRGEGNKDSNNKDIGNSKDKDIGNKDISYKDKDKDNNPNPIISNSKNPNDTNPNPNPNKCINTNPNPNPNKCINTNPNPNPSINNNPGISNNPNPSINNTNTNQSPTFHLTLRDTLNNTYTNIRVNNIISEPYYLPLLTYVKYKIIRCVCIIKGEVKIKNKNIESSQVIFLRGELCKVNDIFLVVLGNRECVAPKGYNVCIISMVWDEGGGSDLGGSVGGSIFDISNKGDNRFDSSNKSDNRFDSSNKDNNNIQDNNNIQDNNNIQDNNNILNTVAGMLGNVVRKYFYISEVRECKEKREGIYITNSVDHSTHFESIYKEVERMCGLLGVSDVLDDIEEMCGLLGVSDVLDDMEEGYRDVGYRGVLGRDVGYRGVLRIGVSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD1</accession>
    <name>A0A4Q9LUD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0828p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000828">
        <property type="protein sequence ID" value="TBU12258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0828p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12536" checksum="FB257990F6A5170F" modified="2019-07-31" version="1">MYFIDLLTASSTFAEQHNASLNIMRAEESTPINYSRPIPRKPKKKICENFLLERKSRIMNSSVKRKLDFDLNISQNIADSSYIDERTPKENINLENNSKKRAKADNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE8</accession>
    <name>A0A4Q9LUE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0820p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000820">
        <property type="protein sequence ID" value="TBU12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0820p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="20960" checksum="B3B03FD5DE6BCA9D" modified="2019-07-31" version="1">MDDFPLMFPKESRFGDKNDQNLYISANIITFEEFFYFYKTILEFPYLIDNLNEEKYLLFMKILNIFKFERNSSFKNLIRFICCSIIFNSIPFKERNFTPKKLQNYDLPKYIDLSKMVLVEILEIYKFPKGAIGIIKGISWAKSAKKYYKFDFINISDKFLYFDTNIIREFLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL0</accession>
    <name>A0A4Q9LUL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mismatch repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0795p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000795">
        <property type="protein sequence ID" value="TBU12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0795p0010"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="302"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="723"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="903" mass="105358" checksum="38A6147C3EC1A813" modified="2019-07-31" version="1">MIQQLSTFSSETIQSQQTFTNIFSITKELIENSLDAESTVIKVFIDNLSIKIEDNGIGINTIEKIGIEGFTTKSEQTHYVLGDKPKPKFSFGFRGQAIFLLRKICDMEIISKESSVPYALKYNLSKNTEISKTFKEPGTTIIVTNIFKNCPIRRKIFYSQISKDTEKLISLFKSYCIVYKTEIKLFLKNKLIFDESGFGNIKKYFEINFPEYFNTKNKNEHGNIKDVNINEDGNINEDGNIKDVNINEDVNINEGKNYINEGKNNINEGKNNINEGKNCINEGKNCINEDGNTKNTENNFEDEREQNEQTSEFNSYIEFENENFYFLISKISSVSLKSFIFVDLRPVKSKKITKQICQIFNNFSSNFPIFFLKIKEDSDVNVSADKTDFVLANENNIFNVLKDVMERNLCLYKYVSPMNCNYEIEKQEHKDYKEINNELRKDYSRDLIRDSSKYLQTHCCAHKNNDKESNTKTFFYENLEKFISNDSLENEILTKIDENKDKNYKISEKNIFSRILNCKKPKFNDKNSENFEDKKSERSNVLNEKSLNTANNKIRNKKYNRGDNISSSSSTNEYKKEENYNESTEENIFIAPTDINLEENNDCIPINHKQAENNCIPPVNQKHEENNCIPPVNQKQGADNRNLVSANHKHDENNNYIPPVNHKQDKDNYKNIISQDIEEQIETPNPFYIEKTKNIFLHFDDPIVSSLNTKIILTKKDFLEMKIIGQFNCGFILTELIKENKKYLIIIDQHAADEIKNFEFLKNNFYLKKQRLIVPLNLKLDSLEEYIIKSNKSVINRNGFEINNNLQIICVPIYKNQIFGKNDFYEILSKLKNTNQSEKYIFCDRIRDIMASKACRQSIMIGDVLSYKEMEEIVRNLTDLNIPWNCPHGRPTTRVLCVLEHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT7</accession>
    <name>A0A4Q9LUT7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MCMDC2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0760p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000760">
        <property type="protein sequence ID" value="TBU12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0760p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058769">
        <property type="entry name" value="MCMDC2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26063">
        <property type="entry name" value="MCMDC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCMDC2 N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="15469" checksum="FCDE60C7EA75282B" modified="2019-07-31" version="1" fragment="single">MNVTCKDDTFAQNSKNILEKIIKWNIFIFENTINEIKKAQKIDRIYFLNIDIDFLKLCNLSPEFSNNLIKNYKEASHLIKNQIFISIKNQIYPLNLHLDFLIDLSEFFKIRLIPRNLPYLICLKNIRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV97</accession>
    <name>A0A4Q9LV97_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0729p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000729">
        <property type="protein sequence ID" value="TBU12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0729p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22219" checksum="DF25A50D9EF19813" modified="2019-07-31" version="1">MLYFFIAFISTCDFSLKLIGTEHYFGVSPVSIIPTIVSRSLAAILTTEQKSEGSSELLLHVNGRNKVLDYEGNGKRVIIYPAHGMKNQIFEIKLDHSGAYRLINQGMCMQYDLPTSSFMKAICTNEPNQLFNMIDPHETFEVNKALGCKATILYGRFYNREVRNNLNCQPESYSRSFKCRNEKPSNSWSYSYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE0</accession>
    <name>A0A4Q9LVE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1133p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001133">
        <property type="protein sequence ID" value="TBU11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1133p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="14285" checksum="1C066A6F11429CFB" modified="2019-07-31" version="1">MHFFVQRKSRFVLVGLSYKFSVEIIPYVVTWDSIVPKYHKTYAKRLQIPKNIEAYIQSIALKMTVETISFDRRRRLDWERASLNNEEDCVKTENTKNKEPTINANKELESEEEIEVVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN5</accession>
    <name>A0A4Q9LVN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0327p0030</name>
        <name evidence="2" type="ORF">CWI38_0756p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000756">
        <property type="protein sequence ID" value="TBU12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000327">
        <property type="protein sequence ID" value="TBU14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0327p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0756p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="38570" checksum="2C89C245740EEF72" modified="2019-07-31" version="1" fragment="single">IIQDAIIEPNKNYKKEKIEFVTIKPDLQAILDKYLTKKVENLSELQDIQKVFELSFLDSQYISNKEKIVDFINFLDKLKFEYLQYNIELPFDTKDLKEMCSKSLDIQEIEKQIDVYEVRVALLRDKYEILKNKLENICNKIINISEIKEYFSNDEKYLQNLIDITKLHDNTKLIYECTNRNTYNNESINTINNNEYTNNFNGNQEYLQKYFSNPEFINILFKDIKNINFIKKYILLLKNNQSFKNLLRKYEILNCLQNIEDFDMKVILLELISNKEIKIEELVNKYQLDKIEIVKKIYILDYKKIVTKDTNNNVIKLNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV4</accession>
    <name>A0A4Q9LVV4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1055p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001055">
        <property type="protein sequence ID" value="TBU11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1055p0040"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="10148" checksum="DEBD4ED5CDD71079" modified="2019-07-31" version="1" fragment="single">MKKLITSALPYVNNLPHLGNIVGCVLSADVYTRFCKKRGQKAIHICGTDEYGTATEMTAIEQNLHPKEIVDKNSVIHKNIYDWFEIHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW10</accession>
    <name>A0A4Q9LW10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0315p0020</name>
        <name evidence="1" type="ORF">CWI38_0589p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000589">
        <property type="protein sequence ID" value="TBU12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000315">
        <property type="protein sequence ID" value="TBU15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0315p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0589p0020"/>
    <dbReference type="OrthoDB" id="4737882at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24664" checksum="00E3971DB6CD8EE8" modified="2019-07-31" version="1" fragment="single">MSEDQLIYEYALLFLEDRVILGLEEDIEEGIEEESDMIDYVSMFYKEDTNLYSNENTGNKDINLYPYNNYTLNSKYTLNTSNSDSISPYNPYNNFTFNNSKIKYSPFYQFNSTPKSKICIKKEKGLKREKSLERDMSKWRKGSINKEKSIGRYKSINNEKSLERDISIRRSIGRYKSINNEKSLERDISIRRSIGRYKSINNEKSLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW75</accession>
    <name>A0A4Q9LW75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0907p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000907">
        <property type="protein sequence ID" value="TBU12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW75"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0907p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020692319" evidence="1">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="30413" checksum="F0434C0393BD0307" modified="2019-07-31" version="1" fragment="single">MRLQVLLIAIELILTAKKSSKKATWNQNIYPKLKNQKNICYFNSLIQCLYNIESFFDFIINHDKNPSKPVTSNIRAIIGRMSKEKNSIESVSYLENAIFKYNDHGFVLSKQNDASEIFIYIINKMIEEAITSKINEHKSIEAKENKKLRELFYLSFFYKFKCQKCSYASRTNNEITNAINVAIAKSVQEALNKHFKSSEPVEKDCEGCKGKNFATEKRCEIIDSPQILTIIFKTFNNDAKKLQNEIFIEENIVFHRSQYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW89</accession>
    <name>A0A4Q9LW89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0714p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000714">
        <property type="protein sequence ID" value="TBU12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW89"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0714p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="93085" checksum="948AA7430E2034CF" modified="2019-07-31" version="1">MFYKKQLLSFIYLLCSVLSKKKKRVLNKIQGSKEVNTSCDDNNTVHIYFQNTPKCMMNCAIYYEPRLEAFFKISREFFDNSSHTKTMNQALNNLNTEIIKGEKIFYTTHEIYVMHYKNCLDVFEGKLLGLFESWVPLRLPEKSTIIKMLGSIKSSLKSQNSISKLNADETLNKIKLVSNKNSKKMIEIFKGILENKNFEQFVFYQLTLFYDYFFSLKILPCSDFLTIDYMLHSKKLPSIDEEAIRSATYLKEIKEVYCANKWNYSLYEIKKEREAIGISEKNSAISNGLSGFRKYIFRDFKFPFDSERSSTLGILNREKSIIFFNNEFPDYIFPDKNIFPSDPVIPDFGTLNKFKRANISIILESEYLIIIFIKDYIEKFGEECFYLNFSLENIFNENSENRKILNNVFSSIQKIEPINSEISENLYITLSHITVDVHIAFAFYKLDTRLFSFVQNEILSVINSSDLKEKVKEKIFIHPDIYYVFFDLYKLCFKKATIKYKALRQIKDISFMDLSDYANIYYNLYNFYYEFVNCGKSGKTVDHLATRCEKMLGYDYTRRHNEVVRCLHLLLLNRYKFKSLKRIRSHSVQEIFDNEYAELRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITCQDSLQIVETKKLRKYDLLANDLIISYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVIKKTVETISFDRRRELESGLNAEESWKSEMHEEPTPPLKEEKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK0</accession>
    <name>A0A4Q9LWK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0849p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000849">
        <property type="protein sequence ID" value="TBU12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0849p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="29137" checksum="A9AD669D84A273DF" modified="2019-07-31" version="1">MTGKKCKILDFGNKILNKSEEILKEEIGKVVVRTTKHLIFIDDLELHALDTHEKLMFKNKHKINSAYMYSRVNNTRNLDLIQQINCVVQYRDIFTKDNNMQKFLSTINLHAEKFFNYIIGVLRLEPVEISRNTRNTRNTRNTRNARNTRNTINTRNTRNTINTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTRNTINTRNTINTRNTRNTRNTRNTRNTRNTRKQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR4</accession>
    <name>A0A4Q9LWR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0870p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000870">
        <property type="protein sequence ID" value="TBU12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0870p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13780" checksum="8CAD36EAA45A7F60" modified="2019-07-31" version="1" fragment="single">LKRLQIPINVEAYIQSIVLKKTVEMITFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPLLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW7</accession>
    <name>A0A4Q9LWW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Insulinase-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0486p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000486">
        <property type="protein sequence ID" value="TBU13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0486p0030"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="180"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="370"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="734"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="880" mass="104047" checksum="C9245D83013938C3" modified="2019-07-31" version="1">MICKSNQDDCKYEYLQLKNGVKVICISDINADRSACAVSIKTGSYDDPNDYSGLAHFLEHMLFMGTEKYPSENEFFDYISKYGGESNAYTDNKLTLYYFDILHRKFKGALDRFSYFFKKPLFIENTVDREIMAVDSEFKKGLNSESYRIRRMLEICCHPDLPESNFTVGNLETLKKPQIRNKLIEFWSQNYHTADISVCLYAKESPEVLKNMAIEMFKDVINNKNNCNNQKILYDNFKIMEKYPFKPEFCNRIIKIKPLKDISKLQINIILPSEYLYLDINPYEFIEYLLIKEEQGSLINILKNKGYSFGLDIDYESLDSYTHFSISVCLTSKGCKNYLEVIKEIYFYLKNLKISEDDYTDLKNIRNIEFTFLEKNHPIEHVENICRALQYVPYGNVLNYKYLFKKFDKKFLLDLIGLMCSQEKWLVFLINQNGKFDEVENIYNIQYDLGEFLPGLGENISEIIPCDSYKCDVLKIEDLLMEKSMVKNRSYKNDNGILNYYFSEEFPIPKTHIMVLLKNEEINRNIVQIKVFLEMFEEKFVQKYDGFLKKSLLNFQINSISEGIEIIFTGFNKKLPDLIEIFFDEFISNSWCDENMFQTVKESLNENYISEIYDMPYRRINQGFKQIFEPNFITSEEKMEILEKIDLNEIKIPKKYWAEVFVCGTLCYEDGLKVFNKITGVFENSKNLEQKIKEENIKIHLKSNDELNKACAVFLKASIKPTYHDLASLHFIYQIGHEKFFDTLRTKETLGYVVSSSITNFLGASFLQFIVQSEKDTGFLTKRIFSFIDDLHEYIMKMKGAEFQLFKTTLIEYYEEKFKNLDELSTFFWNLSKRNFLDWDFKDKIKEIIFKLSKIDLYNHSVWKDRAIVCVESKGNENNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ6</accession>
    <name>A0A4Q9LWZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0480p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000480">
        <property type="protein sequence ID" value="TBU13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0480p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="18804" checksum="C16E53CBFC2A082E" modified="2019-07-31" version="1">MEKEENYKFERDKSFEYLLEAARIEYIKMWEDQLYQNIDIYPQILKETTSNEMDLSYYDTDMFEEPGYFYDSIYSSDYYTEENNLNYRKCRRYESLEKREERLRKNRERVRIRRANETPEERAIRLEKCRERIRRLRFFRKINKKNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX08</accession>
    <name>A0A4Q9LX08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0779p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="39923" checksum="63FC80869E0290A2" modified="2019-07-31" version="1">MIFYYLISVFTTIINRKIILDYSIIDEINCNKNINTLNINNIGDAYLIYCGISKREYKYKKSEKNVWCEYCEGMKNIEENNVHFVMAIPNYVFEGSKFVFMFYSLVSTHISEYNVLICWGNSVKNLKYTSLKPNNSLKYDSVIVLNKPFIFVKKLRVEVKKNGFLNFFKSIFPRVKPYTVICRYEIENISRNGDSINQNVNTSEKQQKNDKKTSKFREDFSLADPRHILQSFKIYTKEKLNFYDEYGIMHRMKYNDDNTIVLTPRYFLHPGFSTSFNISWQCKDIKEMLNNMPFLKSCSKDCKIKFKNGWFENNYEYVGCIENSINDAIYQQKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF8</accession>
    <name>A0A4Q9LXF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory subunit B of DNA polymerase delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0713p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000713">
        <property type="protein sequence ID" value="TBU12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0713p0030"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="192"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="433" mass="49572" checksum="07B525863052B6AA" modified="2019-07-31" version="1">MSKSIFENQYNTTYISRIEKLRPYLHNKVQQKWNIEPLISISEIEKSTNNKVAIIGIIFISSNLKNSIFKELSNYNVTKSKNIKETDILESNTYISENIKYFIEDITGRMELEFENIEKIYEDCFVITTGMCVALFGNKNNQGKFLVSDISFAGYQNNKLDIVGIVENKISVPEMHLSEANKNKNEIQSHNVLFISGINMSSKNTNKNKILLIFDYLNGKHGKIFSNIDTVIILGNFYDSEEKEALEWLIHINILIKKAKLTSKIRIIVVPNLNDPSSKAYPIECLNKKLFSEDFESCENPCCTKIDQKTLLITSGENIFDVLRYLPHGNISSDWDKSNIYKKENVTKTMDVLLQSMYLCPTAPDTLLSNPLESQESFYLEKTPDFFICGNTNGFSFTEKNGCVLVTLPSFSKSGEIVVFDINSFKYEIIQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF9</accession>
    <name>A0A4Q9LXF9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RuvB-like helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0559p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000559">
        <property type="protein sequence ID" value="TBU13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0559p0030"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB-like AAA-lid" evidence="6">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="28959" checksum="E14C1F1E37340709" modified="2019-07-31" version="1" fragment="single">KQRISLGDIVYIESNSGIIKRLGKCETHKRNYDIEAECFIPLPKGEVLRRKEIIQEVTLHDLDISTSKPNGNDVVSILSQIFNPKKSEITEKLRNEVNLNVNRYLECGNADVIPGVLFIDEAHMMDLECFTFLHKAIESPFSPLIVFSSNKLKSKIRGSKNIENHFGMPKELLDRLVIIPLQKNTTEINKKILQIRINEECINVSSEALTFLSDIAESKGLRYVLCILPVLKVFKTKIERNHVEEVTSLFIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM0</accession>
    <name>A0A4Q9LXM0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0404p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000404">
        <property type="protein sequence ID" value="TBU13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0404p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="96851" checksum="D0EAA1106CEE005F" modified="2019-07-31" version="1">MYSLISLQFFSIFFAKNIEYLCLKIQRWIMRYWALFAFLYSLSFLKEINCACQSNNGIIEFALIDINWRKSIGREIIAKVEYWLSRSNENDRFSFCSGKHQFTANRIYPAFFVCPHSRSFLNHEPLHIYRVNYKDDWKVKFRVLNDYLSKNSGKPFLFYGSFDVSYQLLGVFAGYISNDSIVLSENLSYELFYKLIKVLDLLDPISCENLDKFYLALYKNGLINSISSADILNDFYDYKTRLFSEKGLQTSFLGFFSVLNDSLDACLIPNISTLSLFQKKSQYIDRCFRYAKNIQRLVLKISACSLELLMSTLDDKMRIFNWLLTVTKIEGFYFDDTENTYNPIKRQNVCGFIRPEIPIRSSNLLKAVPPEFFLNLSEANQQRITYLRFVNIDICFATFQTIFEKNKVSFLEAAYCSSVECQKITKFLVKMPDLNIFKLRDMEMRSDDANRILCSKIRVLVLDTCTICNDSVWSLEKNYIFKYEIMEHLRTLSVLSSRLPLDLIQLLLRSMNLENLNISNFEFLPANSSFSVVAFQGKWNYLQVDKYIPTDYLKSFLRGYSVSFLSLCESRVFSDIQFFFNTGYFSSSVKTLDLSDNSLTVDNLTLIHNFRNLKYLNLSASLPLNTDDLPNLRMFDTLRALDISRNNITSKNYDFISRFTVLESLSISKSKIEKGIWINVLNDQLIASLVSLDLSGVDMYFSDFERIRYCKKLKYLHFKVATDCFLFCYFNILGLASMKKNLNILSVETEGNICFDDLVRLAGFSNLSEVKIESYTFLPVGQEKFVKYDFLNPEFRLEMGLRHYNLDVHTKEILREMFDNYSFSIVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP5</accession>
    <name>A0A4Q9LXP5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0739p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000739">
        <property type="protein sequence ID" value="TBU12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0739p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="768" mass="91782" checksum="48AFF651481F0142" modified="2019-07-31" version="1">MFSFHYCLNLIIFVFIRNSKQKDIIFYVAKENKEQISGLNNHESKNECICRIRRKFDDESTEAEAVEQISKRDTNVEYNQHTLYNIEKTEFKFETLDTINEDNQNIEIFLCHHVKESEFLNFHRFIVSNNSQEEESMTIVKFYNILYFLEYLRVTYEDILQKCLKKILFSLAKAKEIQDLDMDKISSHFPKQEIFSVEFCKILFQVYFENFFSKGKNIYSEFFKVEVETLEFTYEKLYTEDSMQCLIINEKIASFITQNLDNNLVNKNLFILLLNTFDVKYLHIENMKDVALEGYCFILENLKKNIDEIVFNNVSISDQLIRSLERNLNFRNLKKIVFLKSIYETKLQFSEEFSKGPKFIFFTGIVFKDEDLPTNSNVSKNLNTIKRIIMNSKKGKIMNWLFPLKNVIPSRINVERKADNLYLSLFNLEISEEKIKIFDSLDLIYDNWRLNCYYELNGSFNYVFITFENFELKNFRISDSVLPENIRKIVIKNSKIYCNFLKTIFRIPKLKHLSIKESEIYMENEFKIQSKSIKHFFFQMKKEKKCQHFYKLTKLMVNLKEAHLSYYNYIELIFLKNQKIEVKGLCIWNSSTEYFIGIPLKDSTLESLPYKNNNLDFESSSGHLKLLFEKYNFSRIKKLYMMEFSIQASDSEAFGDLFYLKELTLQNIVFKNISFSQLFCSNKEYKIERLSFTKIHIDESTLKFISKLSQLQFLRLDGCDVHSKASSYITFSSLKHLHIVLWDSNDDQWKKFIQHILKEFGAERITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT2</accession>
    <name>A0A4Q9LXT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0404p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000404">
        <property type="protein sequence ID" value="TBU13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0404p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="862" mass="104472" checksum="3D72526F228C911C" modified="2019-07-31" version="1">MNKNNEFSLFGNEIKDMKNKLRNTNLNLFFNLCTGFDINLIFEELKFNDNRNKSIVVLEENDFMWFLRNFENSNLKKIINETKNSEYINRDESNDLIRMNIKDLYDKFFEIDLERIEMFIFINFSFFNYFYESVLFQLRKFKRIIYLGYFMKGISDICRWFSKDSCFINIDMLRKYNLKVKSFEDRNNDFLFENSLNNEIIGEINLNEKILIVCSTFKSQEKCCKEIYKNLESLANNLENLENKKYMNLENKKDKNLENKKYMNLENKKYMNLENKNVKNDRNLGTEIKKYMNFRLENVFSKNIFYYHGKLSNETKIFIEKKIKNLSNYIICSTASILKIQNLKFDKIIFKSTKKYTWEGYVEYNREDIISLMNILSYKTKGNIILYTKSNMKSYYDEFIVGRNVTKSFLYLNIENFILFNLKNKHYLTFKNICEIFKRSYLFFHFEKYPNIYSNIKNIELTIYKTLKDLNSDQIIFLENSRSLNNAKIFLKSFLFTTLDYKTIKMILEFKENNLKMYLKYFCTPKIFQDLNLEKINTTVFKEIIDGKMEKRKTLEEKFYFLIYLLIHKNLLDLKDTTKFFIRIIVEHFVKIIDIFIFLNKRTLKIFFFRNLLTIKAKLSYFLEDQHIKVKTNSEFKENSLILKNTYFEIILNKNIEIKIYESFLKTEDFTVFISNDVNFKIRNCKGDSLFENIYLKNISELYLQFYKTHAYNIFFRINFNKKEAEIIDSSKFYFENIFFKYSFSKNTANQIKSKQETTEYLEEENKNPNILYKTEDCKEIIVKENMNLNLFYKNNPNLNEMIVKENMNLSGTYKANPNLNEIIVKENMNLSGTYKKNITKKLKIKSEKEFKNLKIQFFELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC6</accession>
    <name>A0A4Q9LYC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0653p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000653">
        <property type="protein sequence ID" value="TBU12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0653p0030"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="418" mass="47984" checksum="7CA6B3C97D1C156D" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPLPPSQTCSKMQNSGLNTLPSPNAPVPSSVEVSACEPSYGMTSRCTLAIPEGNRLMALWTIFDSVTADSKEWPRIVFFAVQTRFERMPRNGWTELHMYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLSDTCTLTDTTEYINLRDKFLNKVKEISENEIGKVVVRTRKHPNELVIVKFWISLIEAHVPESITEAAYIMQAAQICYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKIAMHESRKQFRKKNRMFELFRGRFYRGLSERVESEHVVSRDEILSFWSTMWNKNDDTVTYDDYLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP1</accession>
    <name>A0A4Q9LYP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0547p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000547">
        <property type="protein sequence ID" value="TBU13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0547p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="611" mass="71949" checksum="EFE8CF4377738981" modified="2019-07-31" version="1">MITAFILLLKKSLSSNSENITENLSEYASVMNEESHDSQLLSSVFFLKDEEIGKQDDFEVNFEDHIFDYTDIASIYEDKMLSDPYSHMNFDQANVPKDGSQVVKETANNLGKKDLISDNSKAKIDKIDTTEKTVLNIPKREEIKDGPLQHGTIGKFCSVVNHNCSISCQECSYEISKETHDEKNEEIHEYNDYTMVKSSSKRKGPKTRNFTLGINKSVKKFFRINLSHQNMKSNIKNFEHQAAVDFLNNLHREIKIIHQDILPDNSKSEDKVWFEKKFKKKINSIKINGIKTYEDWVSNLKFSKKIVSYEKTFMENSSIEEKNSFLVRFKLKKFEEYISEISKYYILSEIPFFIYSYNKGSIHIKEGYVFYVSFMLKLLEVCYSNNERFDRLNDQFCFKYNNNIILFRLIFYNMLSGIKDFDCKKNFYIVISSLIYFNDIGGIKKTRYKKKIYCIQLNILLHSVFLQSSIDKDVNKAIEFCKSTVLNAIESSNSYEKDCFKKFFLHLRDIDLIREYTKIYSLMKNQALCEKVNLVFDEDSENLLIKYSKEGTYANENREYIKDLFTLETLITCLNSKLVYCRYKLRDNFNFCGKKDFWKTLNAELQKSLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT7</accession>
    <name>A0A4Q9LYT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0426p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000426">
        <property type="protein sequence ID" value="TBU13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0426p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="63855" checksum="145A5FD4993B412E" modified="2019-07-31" version="1">MFSIFKFCCSIWCLNDLLSEREDYNMILPIYLEHNALTYVNTFRNYFPTLAIETIERNFGEIFNFDHSEAMVSNEEYIFPILHFCKLFLNISGNIEIFYCNFMLLLIRMKYIEYFDKLKNSHTNDKKYFQVSLNFAWNLQIIVNTLYDFLNTEEERIKVMFFLTNEKMKILDKKTESFLDSSYFKFNFNFHDLVLKCRCNPFSVKWQEFFEGNREDIFFRILSLFFLSLYENTTSFIFDDNNFDRVKNCSVIIGDVFFTRKINEETDYCMAKVNIVFDASINKMGELMQKNSLLSGQESFNKFFMACAQECLPTSSTVTYTYDKAEIIWHIRNLIELYKIYDINSDDFEKIAKICNIIYILSYDFYSDTKYIQLWNFCLYKLSYLKEVLIETDFKHVDFDLSKKIVALCFEYHFSIQFQQFRSKLNKIRIFEYSDEFNQPILYVRSGYQPVFDSKLTLFFNHFSENIFFVKFLVPTDLYHYIFHNNLNLNVSIINLLHCSMSIQNETPFLSAFTKEYLKFKKIVNCYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV9</accession>
    <name>A0A4Q9LYV9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0567p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000567">
        <property type="protein sequence ID" value="TBU12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0567p0020"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="12">
        <location>
            <begin position="146"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="458" mass="51119" checksum="3E93FFED3B648D8A" modified="2019-07-31" version="1">MKIQECYQKIKCRQILSSRGTPTTEIDLHTSFGVFRSSCPSGASTGKKEAKVILDKNSDEYNGKSVKKAIFNLKNIVIPRIGDLNETEIHDQSKIDNFLIHLDGTPNMSRIGANIVLPLSLSFCRAGAVSLNLSLREYISRMALYKNKMPFPHFNVLNGGSHAGTNFPFQEIMVSFFEPEFSKNLESGVKFYESLKSVISTKYGNNSTNVGDEGGFVPPVETLEDALDLIMTAYSQSNLQNMKIALDCAANEFYSQEKYTIYQKTQNSNKKVSLSGTELQQYYHQILKKYPLIYSLEDPFAETDTSSWISFTNQVGSSIQIVADDLTVTNPDLVEKAAQNKMCNTLLVKPNQIGTVTQTLKAVQIARQNNMKIMVSHRSGETEDTFISDFSVGIGAEYIKAGAPNRGERTCKYNQLLRIEESLKKKSNYDLYLKVLLLVVIVKGVLVSIFKGVLVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ06</accession>
    <name>A0A4Q9LZ06_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_0568p0020</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000568">
        <property type="protein sequence ID" value="TBU12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ06"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0568p0020"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="332" mass="37565" checksum="0B937DB4DF119005" modified="2019-07-31" version="1">MLVFVSTTLLSYYTASFLISYLSKRLKITGIDCHKKDKPVITEGLGVGSGLSFCVSLLLLMIIYKNTGKEYMNYYGICSTLLFTLILGFMDDLIDLEWRYKLVVPAVMMIPTLLLYNDSTYVILPLFGLIDLGSLYYIYMILVGIFSTNCINILSGINGLEVVQVMILSIFLFFDGVLSRDIFMVRCASCLFFSSLPLYFKNKYPAKVFVGDSFCYFGGMAISCVCILGHSTRTLFFLLGIQICNFVISLPQLLKIIPCPRHRMPDFDGEKLIASKWNKKNINLTLLNVILCLVGSMEEDKLCNLIGGLQFLWCVFVIFVKYSFFVKVVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK1</accession>
    <name>A0A4Q9LZK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0208p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000208">
        <property type="protein sequence ID" value="TBU19507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0208p0020"/>
    <dbReference type="OrthoDB" id="2186465at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38056" checksum="2E32CC68C85246BE" modified="2019-07-31" version="1">MTTYSYEEVYEILKNGCDKPADLNFDEMIMLDHPEEPHIYKKLTESEEIAYKDKKYGISSFIPKKAPNYKRRQDNAAFNDESVWNVDLTSETSGSFDAKGMFIASKAVEDISFENLDCCWLLKDSNKKILGPFVSNEMEEKMKNNLLDNFYLKRECDKIFLPFFTLKEKFSNPFTVEKNIVDNFFTESELQQNLKTLKISDKNEQTPKKKPAKNIVKKEKNIEDELSESEIKKILENCKKSQNFLIKRNVKIGLDEIRSNLIKMKKEMGLSWLARTTSMNNIECNDFLELLIEESKIRICLDIDKDGFLIINETDFKSKKTPKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN9</accession>
    <name>A0A4Q9LZN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0442p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000442">
        <property type="protein sequence ID" value="TBU13401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0442p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="774" mass="92792" checksum="D480F6F8CC3E8623" modified="2019-07-31" version="1">MIGTSIKEFLDNLICYQRGISFLILVSFGVDLKAKDNLVIHFYNELFYKSPETYLIDKKVVFSKFVKKKFKCYAHIHCLDCKKFTIKNRTDCPFNFKYEDLAEPNTIIFVNSNILTYEDFIHCYSILKNTSGLKNDLNVNDFLLVIRILDIFKFKKDKCFKQIIRVLLMSLFFKNEGIHKKYNINMKTVLSPSLFKHIFYEFGRIYFFRKDFFKYSLLYGCQSDAKIMKELYQNFDTNYIGIQKFISVNSSFIAKINNLMKFDTALEKKFEIVFGQFKIQAMHIYFDRVLNNLSTHLQYLFFSHIEELCISDWHNTLDFFEQIDTNYVFQYVKCLIFIRCEFSSFPRNIFKNMISLKHIYFILSRILSIDYFNEKYKRMQIFHSFIYDELISKENINNFREITNNQPIRIKNISKKDLNSSNKDMITVFAFKDEKYRVYTLNKLGFEFENFMFDVFISNIQTIKKINLTIREICMKGLIFKNSFINQNINSIKIFSSRLEDDILHNILTIPSLKKLEILYCTIVFNKEIKFKKNMLLKYLFLEYCNFENPNRFVNLINSMPKLQQMNLRYNTNLNVFEQNYKDKISEFEFLTKLVFCKINDFEGEIPEFPDFKFISNLDIGFRYKEGSIFKLFFNKSLNTIQYLSIHSFKIGKKDEHAISKSKNMKHLYFYDCEFINITFSDLFDTTETYMIERLILEKISLCKPDVLFLNSLIHLKILQLEIEKFIIDPSQLLYFYDPGKSEIMLTLCAKKEHWCEMCMFVEIYGGNNLIYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B7</accession>
    <name>A0A4Q9M0B7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0139p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000139">
        <property type="protein sequence ID" value="TBU20060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0139p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="11911" checksum="AF7B25FD0399F302" modified="2019-07-31" version="1">MDSYRNPISIIKVNIKLDKYNRNKNLSVNNRNARITQNTKVSSSNFEKNPNYFLKIKTEEIKKNKRSNEYFFLKIILKSHENLWLPGKKYLADSESEIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M121</accession>
    <name>A0A4Q9M121_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0877p0010</name>
        <name evidence="5" type="ORF">CWI38_0349p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000877">
        <property type="protein sequence ID" value="TBU00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M121"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M121"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0877p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0050"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="178" mass="20613" checksum="B09FF1346EBD2298" modified="2019-07-31" version="1">MGQLCSDCCKRPVCRIVILGLDEAGKMYLYSNLTNKKEEHKNELVYKHDEIKLNGMSIFLCSVLGDEKARNLWSVQIQNSDGIIFVVDISNEASYKEITEEFQRIMDVKAFTEGMNILLLCNNGLKTDREYREVGDAIFSPFLENPGIRINYCSIEEWLFIDDGLEWLCERIKTKNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M168</accession>
    <name>A0A4Q9M168_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0288p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000288">
        <property type="protein sequence ID" value="TBU17097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M168"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M168"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0288p0030"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="7"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="45651" checksum="43E652B24003BAF9" modified="2019-07-31" version="1">MTHNGLNTFQGITAMVTTMMGSGVIMLPSAFGDAGYVFGTLQFVSTSIISFFTLYAISSAAVKMNKNEKQTYYSVCKNINKFMAVFADLCIALQGYSCCLVYMIALATWIPKLIGKEISRIYMVMIFLPPLYYLASLKNLKNLRYVSFLSVGSVTYLASLILYYSLLTRGKYSEGEKVNFNYKFNSALSVIIFALGCHQNIIKVYSELQNKSLKNITLISGLSVLFGSSIYLVIGFFGYFIAGSSIDGSILDSFLDKSTKLSQFLIQDTFDKFMILNKIAVICFCCVMMSAFPTQQQPAKDSVINLIFLITKKPRNESSEDTMRKILTFIFCITVGILACIPDLDFDSVLKFIGATAATSITYIIPSLVYIFTNHYYGFLRVSAIVVAIISTLLMIYMVIFNFTEDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M171</accession>
    <name>A0A4Q9M171_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0317p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000317">
        <property type="protein sequence ID" value="TBU15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M171"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0317p0010"/>
    <dbReference type="OrthoDB" id="2195369at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031523">
        <property type="entry name" value="Acetyltransf_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17013">
        <property type="entry name" value="Acetyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="238" mass="27997" checksum="2DDE515A724E2B02" modified="2019-07-31" version="1">MFLLFLIVITAQPYRFIYFLSNNQSFKHPDQICDDMLNIYKEFNLDLKKEEIFGDVQRFNVFQYRNNKELIASLFINLDTYYGMKNKNIISCPIMEIYSVFVDEKYRGKKIGPKLILESVKFLKNMYKLNDDTLVALHLNPKDKMMNVSYSIYIKMGFDKSSFVTNGPNFFQYKLEEIPNLIDPVVLVNNPSFSKYKGWFFAMYCPINNIHMPDSKTETGLLSEYGSKLRKILLDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K1</accession>
    <name>A0A4Q9M1K1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0057p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1K1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0050"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28403" checksum="1A110D20E4CC5C1F" modified="2019-07-31" version="1">MNISTTVEAPFSFTKKQEYLEKMEIIKQKQLTLLEQRKVQNKEYADRTTLSLISDYKKEISEEKRKEQESIKNNSFYIPKEPNFFLVIRIRSICNVPPKVKKILELFRLRRMNNAVLLKNNSSIRVMLQKVRNYICYGFIDIYMLRELIYKRGIGRINGKEVNISNEVLEDYFKGEIKCVEEVVNHLYGGSSMFKRVNNFLCPFTLSCPLKGFKGKKGKDYLQGGCAGFQYDKIGELVERMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N7</accession>
    <name>A0A4Q9M1N7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0143p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000143">
        <property type="protein sequence ID" value="TBU20047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0143p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23245" checksum="2B73F7CE3B2519E0" modified="2019-07-31" version="1">MEENILQIYNDIKRHVRCITTSFIFISTYNTIMSILVFILPTGLKPSDSYKKYVNSINKLFKRCGFLAVVIIRIVNILKLGREKDIFYSIPLDLLLFYVNNKNIGTFSIVTKAFKEKNLNPSGHMFTFSYSFYILTRVLLTSKSVFLISTCLFTILIYTFLATYTIIYHHTKWECFIGLILCNITAFIHNYILAYVEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E8</accession>
    <name>A0A4Q9M2E8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Insulinase-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0186p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000186">
        <property type="protein sequence ID" value="TBU19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2E8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0186p0030"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="180"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="370"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="734"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="880" mass="104253" checksum="D904DBF94FBAECCF" modified="2019-07-31" version="1">MICKSNQDDCKYEYLQLKNGVKVICISDINADRSACAVSIKTGSYDDPNDYSGLAHFLEHMLFMGTEKYPSENEFFDYISKYGGESNAYTDNKLTLYYFDILHRKFKGALDRFSYFFKKPLFIENTVDREIMAVDSEFKKGLNSESYRIRRMLEICCHPDLPESNFTVGNLETLKKPQIRNKLIEFWSQNYHTADISVCLYAKESPEVLKNMAIEMFKDVINNKNTCSNQKILYDNFKIIEKYPFKPEFCNRIIKIKPLKDISKLQINIILPSEYLYLDINPYEFIEYLLIKEEQGSLINILKNKGYSFGLDIDYDSLDSYTHFSISVCLTSKGCKNYFEVIKEIYFYLKNLKISEDDYTDLKNIRNIEFTFLEKNHPIEHVENICRALQYVPYGNVLNYKYLFKKFDKKFLLDLIGLMCSQEKWLVFLINQNGKFDEVENIYNIQYDLGEFLPSLGEKISEIIPCDSYKCDVLKIEDLLMEKSMVKNRSYKNDNGILNYYFSEEFPIPKTHIMVLLKNEEINRNIVQIKVFLEMFEEKFVQKYDGFLKKSLLNFQINSISEGIEIIFTGFNKKLPDLIEIFFDEFISNSWCDENMFQNVKESLNENYISEIYDMPYRRINQGFKQIFEPNFITSEEKMEILEKMDLNEIKIPKKYWAEVFVCGTLCYEDGLKVFNKITGVFENSKNFEQKIKEENIKIHLKSNDELNKACAVFLKASIKPTYHDLASLHFIYQIGHEKFFDTLRTKETLGYVVSSSITNFIGASFLQFIVQSEKDTDFLTKRIFSFIDDLHEYIMKMKDAEFQLFKTTLIEYYEEKFKNLDELSTFFWNLSKRNFLDWDFKDKIKEIIFKLSKIDLYNHSVWKDRAIVCVESKCSENNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H9</accession>
    <name>A0A4Q9M2H9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0006p0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="597" mass="70691" checksum="5EFEE8DFC7CF778A" modified="2019-07-31" version="1">MIAVTKVIFLFSEEDHDFDSLKVNSLTNENCYVGKKYEKDTMTERQTKKFSLKERYNIFVVENIEKYPIIFKRITEKVDKTQSDIVIVLKNTKYSEFKIFDNFLKTCYLSQETFSINHFVLILYCLDSLKNLNIFCKNIMNIQMKFWIDFLVSNEDSLNFFNMVFGIYLAYLNFNNAYILNDYINFESYFLFGTYDFLLTNKNYRILKIDETFLNIILARETDNFFITVFLALFNAEVIFIENYDLLDAKSLDKCLFMITNSVDAIVFIDISIKDSVISFINSNNIFKKITNLYFYCYSFTEITDVLNKSLGIKKVFLVDWLENQNLQYLSSESSESIDKLKLLINEKSLNIGIIEKNFSEDSELKSPEYYLIENFNQNKHVLLQKDKMSKIKLNIYLSNIECKNRKLMYLKKSCHYELKSLKIFQSEVTFEDLINIVDFPCIKELELNEVEIIQIIENFEINKNNQSLLNLKIIAPKISMKTKIYDFIHCFNKLESLNLYLDEDLIGKEKCSTVLFRSAKDLNLLTFVCTKFNRYGYNFIFELKSLAYFNLYGCEIENLSIFRFKRNNFLALKLDISLSCDEKLNSNLKIVYEKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I7</accession>
    <name>A0A4Q9M2I7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit gamma of coatomer complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0009p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2I7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0090"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="823" mass="95274" checksum="BE88C6708C1D0780" modified="2019-07-31" version="1">MTEISSEKDLLKQFQTTFAAQTPTTRKYVRALNALANFVSSHSLSPDSLKSIYLYILRIFTSKDVYLRHVVYSVLPMIIKKTPDSYFGISVVSKDLGTIKQDNLKANSLSTLFMMIPPVMLNDFEKFVLQALLSNSIQRKSTAIRILYRILTDSNIEKQNSHILVKKWTLNHNFFTDKQITNYHSLALLYELKSSDINSLLVLLKENKDRRGIPAFFIIRLSTHLYKKNIKLCSEILKKYISCKEEMYALEAIRSILTFQNDDILQFLPAIVSTLRSFLRSNRKIIKFAGLRVLQDLTLKGTESSSENLYLETENYVEESHKFKKESKKTSFVQNSFISAISQANKEIEDMISDSNKTTSLLAITILLKTGNEETVDRLISLIPEFIGTLPDSFKIILISALERMTLKYKEKGKEFLEFANKALTEKGTLKFKRHLIQVIERVIVSYRNEDVNVNIYNEFTENVLNILCSYLEDSQYYELSLDILYILSKFSIQSKNYMHVLNRLILDNSWVRGGALMAMFRMGFVNKNIVVTACYDEDEYIKNVSRFLYGLLEIKEIKRKNEIFSYEELGSLKESVLDVMGVEVDEKKEEIQVEKDFLIKKSEEIVLVDNSDFFVSVEKLIYADFFSFKFSVQSNLEGVNVLNGVIQLLMKGEKNIYEADLGNIGFMEKKNVEIKIFKSSEEIGDQIIFNGVLCYDLCVDDDFNDLETESLQFIPLFINYLDYFRNELPCKELKENKKMNLCLEVRDLMEGREKVLNLLNLRVEDQNIENTKVEMSLCGVHVNEEDSVWINVLLENKGKVYCELNISGNTKEIVDRICRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L6</accession>
    <name>A0A4Q9M2L6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0002p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13516" checksum="8E327C130B712380" modified="2019-07-31" version="1">MYLKDNDGAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERALMGVIMRSEVHEEPIPPLKEEKREEDGEKKFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2R8</accession>
    <name>A0A4Q9M2R8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0186p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000186">
        <property type="protein sequence ID" value="TBU19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2R8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0186p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="29182" checksum="5E1CCDBE4B6834AE" modified="2019-07-31" version="1">MNTKQKKKKVIRFIRDMLPRVYKIIFGLFYMSLFWVFFLLVFFAVAYKHKMMDKDFPLKDIFIKYYLLSVLLCLSNILNQNYSQSSIRFSKYDLTTILLIHVSIITELMMDKHSFDFRYNLDLKSKILYAILKFVIHLCISIRYNNCNFIKKKVSFIIFFKFCCIVYVLIVSESIFEKKFFLFDKEFFLYKFTSYIFVILSTFIYLIRKNGFKQSLLLSIYHLIFLFSLEMKNINVLYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Y9</accession>
    <name>A0A4Q9M2Y9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0180p0030</name>
        <name evidence="1" type="ORF">CWI38_0198p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000198">
        <property type="protein sequence ID" value="TBU19806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000180">
        <property type="protein sequence ID" value="TBU19886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Y9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0180p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0198p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="8127" checksum="8BECAEA06F4B9AE0" modified="2019-07-31" version="1">MIRSIIFKKTVETFSFDRRRGLEASMGVIMRVGMHEEPTSPLKEPKRDEDGVKILKTKNNTPIFHKDEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3P8</accession>
    <name>A0A4Q9M3P8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0110p0050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3P8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3P8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0050"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="256"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="733" mass="86123" checksum="D2AA9EE3606BA717" modified="2019-07-31" version="1">MGINKEGMFLILEKTKLKKDGWFSFLFNYKFQMIINHSNKIESIPLKAKEAHIGYIIKTSENKLKITIKMENKISETYDVNVTDGHIILNIKNEYFYGTIHFFGTKKSIFSELENQMNLASNNINDPFVEQKTMKTDRIYSLQLYNGKVYFVDSLNYKTFWSFTNEFVDTTLPPGWEKKFMKKERAYYINHNNRTTSWVHPVSEQAITKIENKLHRYYFATRKTDMFFSLNIYRLFIRAKRGFLIQSTASTLVNARIGDLMKNIYIEFIDEIGEDYGALLKEYFYKTSFEIAQDFRMQETEDIFDVKPMTEQNYRNDAYIAPVEIENQRRLCVEYDADDIDSPFFQDSENKGMNYLDDATFFTFVGIFLALAIEHEQNIGINFSLAFYENFLRKKFELSHVQDTQVQSSLAWLLKNDYDLYEDVGREDINSLGKNTAVCRERKDYILTLVYENLYESKALAYEHIRNGFYYVAPPDFEDIFNCYDLVHILHGNESVTSILIKQNLVFMNCDENTKEIVFLLQILDEKNEEYLRNFLCFVTGSGTILFNAIKTGKFAIYIEQSKEEGSLVRASSCINRLYIGQYNSKKEFEQILDFCLYNTEDTTTELKALSQKLENKSNINKKCKTGKKTANSYEFRDIFSVRSTQESSQNNIYTQTGESIIAIKKEFGYGREKYRGEREIIEPFSFDRRREQGADMHEEPTPSLKQASIDDYCVTHFKTKDNTPHILIEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3S1</accession>
    <name>A0A4Q9M3S1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0120p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000120">
        <property type="protein sequence ID" value="TBU20166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3S1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0120p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="45203" checksum="65C04542EF526CED" modified="2019-07-31" version="1">MEEFLENYFRDESIEKIKYLYSARIDNKTKISKWYLLILESARKRILNPRNIFVLPSNLSEKFIFKNEVPICVNKVLDYFIEEDNIIHEKNGYFRQICRLFTKDSVFNNKDSDFFVDEDQHTKKNLEGNKNDICKIFQRSMSIQNIKENRIYILKDLVFEWFEIIKKTVDSVIEENYFISRYNHVLNKQELYLLLEILQRYKKIGICKEKELCLILFDKETDTKRKNIAILKSRIFKLKNFIDSNKLQIEKQNFKSNLMNEFVKDRNNVLLQKILQADQFKDSVIEKITNLEQLSIFKKFSQDFPNIKNLYLNYGDGNTHFIDESLFNIDSILSMSNDQENIKNKPTMNYKSSIDLNESKDLKRTDFEQKEKHFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M407</accession>
    <name>A0A4Q9M407_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0661p0030</name>
        <name evidence="7" type="ORF">CWI38_0087p0080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000661">
        <property type="protein sequence ID" value="TBU01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M407"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M407"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0661p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0080"/>
    <dbReference type="OrthoDB" id="2193365at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="116" mass="13382" checksum="DAA6C9B3D3E47DEA" modified="2019-07-31" version="1">MSTIAAPKPLNNYEVDCSNLVKDNLLSVSEFLEFMQANMKINRKTNNLTENISLSTSGASLKIENISGVRVNKRYIKYLSNKFLYQKQLRDWVRVVSGGKECYKMEYFNVEKGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4T2</accession>
    <name>A0A4Q9M4T2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0002p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4T2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26484" checksum="4ADDC7823DDC037F" modified="2019-07-31" version="1">MNKKILWISFSLLTLIFVLGIFGLVSYKSAKKVIEKFEADFKITSQSEYFKNLASMLGKNNIGMFEKKKDGLTFNVLNIYDKDDSDSLLEALKQKDKEKFIQLKDKLQFLNQGNSIRIEKFYTFEDLRSLAKIGLFFTKTNTLESVRKLALFIKARLDIHQNENGADDVFINTISQSVVETYCVHFKNESVISLGELQTFTLIYAEGNIKGSLTDYIAYIIEKSRKKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4U1</accession>
    <name>A0A4Q9M4U1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0541p0010</name>
        <name evidence="5" type="ORF">CWI38_0002p0120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000541">
        <property type="protein sequence ID" value="TBU02156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4U1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4U1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0541p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0120"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU02156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU21028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="315" mass="35845" checksum="2BBC3F00110F7DD4" modified="2019-07-31" version="1">MQKYIRTQNELQNLPTDTPSDLSFNSTHQFMAVSAWDNSLRFYNYSTPPYTMKSQYLHDRPLLCCTFNPTNTHCYAGGGDGKLIIYDLYTGQAVHHQAHDGGIRYIKNMSNILVTVSFDKTIKFWDYRQPKPVHTLNLPDRIISFDCTNEMLFCCTPNNQLTSYELNNINTPKQHKSRLNWQIRSLKCNSDNDIVILGGIEGRIEVKSLNTPSKGYLFKICKTTTEVTSINCISMLPSNNDLISIGESDGTFTLINTNARTRSDILNFKSPVVVCKFSDDSKYLGIASGYDWSKGYEPTVLPNEIRIVNIDNTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5A9</accession>
    <name>A0A4Q9M5A9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0008p0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5A9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0150"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="17961" checksum="4D42B1DD1CADB2C6" modified="2019-07-31" version="1">MNINTGNKTDFRIRNNRPDIFILDKKKNMIKLIEVGITSQESFQKVEIDKLRNLIYKFSVEIISYLMTWDGIVTKNIKFNIKSNIQKIILKKTPGKSVNDAWETNTSLKQASDEQDNGGTTLGERTRNISKDSNLEEETNLKRGKENISKLYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5G6</accession>
    <name>A0A4Q9M5G6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0003p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5G6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8337" checksum="53CF43B3A4739CFB" modified="2019-07-31" version="1">MLVISIGISRRVVFSSIVSISSIVIRRILVIVINSIVISSIVSISIVIISSIIISSIVISSIVIRWVVISSIVRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5P0</accession>
    <name>A0A4Q9M5P0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0011p0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5P0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="38146" checksum="D610A65FF5F5268E" modified="2019-07-31" version="1">MVSIPRCAVDPENNMKFRLEFLGNIILFRSFNEIYRENLKFKLIFNNLLKKFFEYQVRNFAEIDSSQDIKARIMKMFPQLSTVNHYCNKDSCKLNSNIFKKIGVHTSLLSHEKLLIELDKFSLLSFMCEEVLFTKSFYNQLDYDLCIKIMECISDSIIKKIIIRGDEFQDILDFKMYEFNDMAILNDQNYPKEVIELFVENTKRNKLISMYEILMNISKVEYHKYISDVICLKVFFEEEELTDKEIILRIIIEFLFLTGERKILKCVKKLPRDNSGKIWASEMEYMALDILLNEIESKSKENGKYCTSENKKLFEQNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5S3</accession>
    <name>A0A4Q9M5S3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0008p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5S3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="99357" checksum="BE57946699B54573" modified="2019-07-31" version="1">MDIEFFNFIGITWIYMNKNRHSINMKKGIWFSRHNNRYSLIALYLLLLLNSNICYKIEICFVKEDEFGSDSFNDKCALENLDSKCIGTVQSNAMRSIEENFHDENFISNKAVQYSQTLNSENSMDYSFRFNKTTQGAEIDQNSIFNSENYQNYYNNKSDSDMEFMEEDDNIVRETINSSALNEKYNFEMPGFDCIAKNNSSLVFEYPGKFEIRSKYFDRKFESNTHSYKLYIAEITRNGVDFQTFRIFLTVLRFGCNPISFGLQKEQLMDFVELFFDLYCYSESIIILNIFKCLFPLLVLYKYEMFDNEIIRLNQENLGRLRKILIPFFKTFFECINVIFDVKENEILFVEKCQPKKFYFFNEKNIQNIKIRTTPDAINYMKNKIFDAKKTEMYLWLLSIYQIDGIRVSYDNIYYSECIDSDFASNFLCKTAYSVDTEPVCLDFMPFNVFIPKEDLNIKYIELERINISSKMLLLIKDCSNLESLILVKCVFPVNFIASVYIYENFKNLKIFRYVGFPLYISQFKNLIFKNLVALDLSCSFFRGSIANIKFPEQKPSLKCLRLDYSKLNVFILNFLIKDQSLEILSLRGVILYNLLHTDALSGWQNHFYFLDISRCKFNFLLSKGNLFQNLDVWILYLENFDTVEPNKILSQKSLHQSTRRLSLSQSLLSPEILYYLQCFEYLEHLNLSGLPVNHLRWAKDHIFYNSNLQSLDLSDWTISQEDLISLSQFKYLKELYIPRCDLNAGSMKYLLKEWIHTNVLEKIDVSENQLDLADLALLCQLICLIHFIFSEDGAKNFKPKNKAPLISQERTTLEEPTNNINKESDLEEETKVVREVEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVD2</accession>
    <name>A0A4V2JVD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0266p0030</name>
        <name evidence="5" type="ORF">CWI38_0009p0130</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000266">
        <property type="protein sequence ID" value="TBU03612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVD2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0266p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0130"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="144" mass="16219" checksum="D4B41E35514C54B4" modified="2019-07-31" version="1">MSNIKEAIALGSKKTAKATSICTEVSEPFIRINKVPLNIFQDKLMLYKMKEVINVVGTDVLSNLGFDISVRGGGNTSSIYAVRQAFAKSIIAYYGKYFDEYIKQEIKNKLLAFDRYSLITDPRRAEAKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVV9</accession>
    <name>A0A4V2JVV9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2737p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002737">
        <property type="protein sequence ID" value="TBU05622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2737p0010"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU05622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12666" checksum="79FD71AF0CB2E7AF" modified="2019-07-31" version="1">MRKIKWKEIIKNEILIQHKGQDATEIFECIGHSDRSKEMMKEYEIGILDTDSQNDENEGSDTDQVVENQIISNEIERDFFYFGKKIFVFGVGFILIPVICYLLFFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWQ5</accession>
    <name>A0A4V2JWQ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2211p0010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="PITK01002211">
        <property type="protein sequence ID" value="TBU08872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWQ5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2211p0010"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="225"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU08872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="552" mass="63089" checksum="64EA0F839DDF2D5F" modified="2019-07-31" version="1">MSVNIFYATETNKSLKYAIKLSNALISKNIDVGVHSFDDYFYSEIALFITSTFYDGQVPKNGRVFFKKLKIAAKNNDLEFKPPKFFAIFGLGSTAYLSLFNLVAKQIYGYLITLNSISMLSPVYSDEYGDMEAVFDNWVSNVCDSLTNNNYQTNQNPKSSEIIDTNNKPDVSDIEDLSLMLTPSLSKNLKKQGYSLVGTHSAVKLCRWTKSMLKGRGGCYKNTFYGIISSSCMEATPNLACANKCVFCWRHYTNPVGTKWRWNADEPDKILKGMLEEQNKLINSVINGVKTEINKFKGVKHCALSLVGEPVMYVHINKLIELFHKEKISTFLVTNGQFPDQMRALKDVTQLYLSIDAGDPVSLREIGRPLFTDYWERLLECIDILKEKRGRTVFRLTLVKGINDETTDSNKEEQERNENILGGYISLIKRGTPDFVEIKGVTFCGWTQDSGLSMKNVPYHNDVINFAIQLINGLEGYEIACEHEHSCCILIANTKYKKNQKWYTWIDFDKFNEDLQGIEYSCETPDWALFGSREKGFNPNETRYQRKKNQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWX6</accession>
    <name>A0A4V2JWX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1317p0010</name>
        <name evidence="3" type="ORF">CWI38_2150p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001317">
        <property type="protein sequence ID" value="TBT99511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002150">
        <property type="protein sequence ID" value="TBU09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1317p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2150p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036125281" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="102" mass="11751" checksum="C9279B82564D897C" modified="2019-07-31" version="1">MIFYFVLLNVKTTLVNARNVSRNLGLPTECSIFSCIPKRIPRSISTFYYGVFPDYEYDNSQNMKGANSDIIKRNHRKITKALYDKCSTKIKCNGKIHPLPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX03</accession>
    <name>A0A4V2JX03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5089 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2087p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002087">
        <property type="protein sequence ID" value="TBU09942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2087p0010"/>
    <dbReference type="OrthoDB" id="2192459at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031547">
        <property type="entry name" value="DUF5089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17002">
        <property type="entry name" value="DUF5089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="25425" checksum="7BF6C5288EBDA094" modified="2019-07-31" version="1" fragment="single">MKDIYSQEQYQKFLDRKKEKKEEGQSDSAQSSIDEEIKRRAEELEAENYDVAKQARMKLEASGTQQKDTTGRLKSQGEKLRNIKGEAIEVHEGAVKGAKITKDIKREGKLFGFHVPLIGKIKHLFSSDRKIEKEVEVEKERLKHKKNRSTERIQEISSDDEHFNQNSDDEVVKGEGMTNKELYKISNKLKEMNSEAEIQKSELKKQKGDIKKISKVNENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG0</accession>
    <name>A0A4V2JXG0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0055p0030</name>
        <name evidence="9" type="ORF">CWI38_0176p0030</name>
        <name evidence="8" type="ORF">CWI38_1103p0030</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001103">
        <property type="protein sequence ID" value="TBU11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000176">
        <property type="protein sequence ID" value="TBU19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0176p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1103p0030"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="424" mass="48307" checksum="5126278BCB1DB7F3" modified="2019-07-31" version="1">MDPSYQKVTPILPYTNIILNNTGKFYRKIGDEVIQENNLCVLILCGGQGTRLGSADPKGCYVLPDINHSIFSIHMQQISSLGKIYSKEILLLVMVSEFTDHKTEEYFKVNQYFGLKRENIVFFKQESCICKDFNENPYFIDEKNFARSPNGNGGLFKAMKDNDIFSILRKRNIEFVNVISVDNVLARVLDPIMIGCYKHHKFDVLSKSVDRLQNENVGIFVMKDQKIIIKEYSEVNVDGLKDGETQTTTTSTSNSSSANSSITEITSESSFSSTFGENPFQANICNHIFSVNFMENISNKTLPIHRAVKKIPYFEGGKIIKPKEPNGFKDEYFIFDCFVFSNNCGVMNVPRLLEFSPLKNGYDKTTDNPRTCVDDISKRSRLYMEKSGAKIVNCRIFVLPKTSVFGENLERFQGKTFKKDEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ4</accession>
    <name>A0A4V2JXJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0925p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000925">
        <property type="protein sequence ID" value="TBU12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0925p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="761" mass="91100" checksum="2D57E56393895973" modified="2019-07-31" version="1">MSVMFYSIENSDIGMNYMENEGTIIFEFQLKNKYILKSFKSVFLLHNKYLKCILRNDQIRYYTPNTIKILDLENIILELSEIDEEKDNLSTGKYFLGQLSHNFLLRFARYATIDDPFITTLSFIEFTNILLVLEILGFKRTSKNNTFFKYLLVNSIVNENFDFTKFNIFLNSNEYDCDMFNMNLEYLYNIFLEVLCIGNTNKFTFLLLKSNTLFHDFKIIQSYQVYVRYKDKFCKSSIIFFDPNIIIHLEKLLTTDWGKNCFCFFSKYCIIDTFCFVFTKKEPSKKIFNLIYLIKPNNLKKIVVRDMLNNKTGIKTLLLFGYFQITEYLKISCDLNIEEISMILQHSENIKKLVIKSQDACYDILFELNKFAKSHKNMYLKYKCINLIMICQKNYLWQNLSENLIFYIKKFNESFLHCNSCFMRSFVLYRKIRTRLDNNNYQLEKYKNKFFLCSNVNAAYINLHQNKSVQIIHPKLVKYIFQIQKLQDIFFENIIITDILIRHILETKSLISIKIYNSLFPSELFHKYKIVNYTLRGITIKNTILTLNMNFIKFISLFRNLIFLKIHIKNIDSVFQKIIVNRASEMYKVLKYKSVSRLEYFKITINEDITTCFPIIFVFSCFFDISNLSTLVLQYFKLDEKDASVISNLKNLKELHVCVYQQKNEFFLDRLTKILENKMITRLGLDIKNLNFKIFEYLYNFRKIVFVSILFKIIEAYDLTLLHKMKLNYPKNIVFLCKNDPLVSFEVINFCEEHNIAFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK9</accession>
    <name>A0A4V2JXK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0844p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000844">
        <property type="protein sequence ID" value="TBU12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0844p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="32837" checksum="8FB830E93727A381" modified="2019-07-31" version="1">MYKAFSRFARTRQNTRDSYIRIGDVTNGKRTKVPKKFQIFKRNPRYDLIRDGICVRLHSEIEFLEAHSFDEDIILNNFKSLFGETKFIYFRGYSVYSLENIVLLKHENNITDKYYSSYLKTNSICYINESNASVQVIDFDIPAIPMHFLKTFNIEFTYYNEDEDTERKSKRFRIVFKHSNGGFEFNNNLPVECIMKKYKPTNPIYICVLWKNIFDIVEFECESVDSSKCKFLRIRMYNVSAEIPLVKTSFYHVQGMSCIKYLLEIWFFNNEIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ4</accession>
    <name>A0A4V2JXQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0654p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000654">
        <property type="protein sequence ID" value="TBU12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0654p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="475" mass="56123" checksum="5A78140D8F2D77E5" modified="2019-07-31" version="1">MASETNLPLLSNFSISNFAEQPLSRYNTNDTALGSYNHQVVSEAINSCQESPSNNHAGIITPEQDHMQNHSASIHTYMVLNKDKEVVFETKNHAIFKIIGSLCRKDVIRRLEYFYPLIEGEYTISIENILHYRKRINDISDAIKSHVEKLSNIRNYETAFMCKLIKKFRSKALFIFHTKNCPMIYCKPIFLLLPLWIESTIQNELTLAKHLFNVSLILNVTKTLMKYNYECLKPSIDQSLKRNMQLGFLYHFRGNKELFYHHFNLIMEFFGDIFTILGREAYYKIFKLHTDSEFLVNNCDNAFLFTLAHFEITAILFDVFILLSKENFDFLHSIINDYEVLKESQENKDLKFLNYMEKMLDEEGYSMSENIRKVFYDLASIYGKLFQEKGYCDFIQNPFSLNFKLWFRENMAGLRRMLLRNIVPKYFDIRNFLTSCNIFLNYICKVTLNPDITPIGFEDILSEKIFRFLQVKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV1</accession>
    <name>A0A4V2JXV1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0499p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000499">
        <property type="protein sequence ID" value="TBU13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0499p0010"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21906" checksum="3FBF46D08EF7AA61" modified="2019-07-31" version="1">MKFGKNSSKHYIYLKRREYEYNLANFELRKHYMTEEQFFMESVLLELEYNLFECDEKDVFEYNFEIYGNQIYLFDEYNPDKIKESVFVDDASGTDENLLPENTKKYKKENKNTISSRRRAKIFRCNNSFCNKKYTSSYGLKYHLIHGHGSKTLKKYVCDETGCVKSFKNPNGLKYHQKFGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX7</accession>
    <name>A0A4V2JXX7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0390p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000390">
        <property type="protein sequence ID" value="TBU13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0390p0030"/>
    <dbReference type="OrthoDB" id="2193149at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38614" checksum="2306F5AAFA723950" modified="2019-07-31" version="1">MKSFDIKAAIEIYSKEKRDVKTYFVKRKKEKELHTIEVDVERSFGFLKGEDKVSLARKEIFKEILFKVLKTIPVEYLQSMSEIVSVIVYYNFKDIVEEKLKQIDIAEIKSKSNKSNINLSSTSLSKDNVIWMSENESTSKMSESRLSDASTSSDNFDYDQFIDEELFKKTCVTVTNVLKEKYLPLVDDNFKMYLRYNNIFIRMMAKRNKKIYVDESLKYMNTTLTWFIRSLVNIEDILAVYGYFLCCPTSFPFLLLVKFYDKIDNKIPIERLNDNIYQELVTLEREFLEVEFEMSRPTTALGKKTGLITVGSIIAVGAAIIIYRLSKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY21</accession>
    <name>A0A4V2JY21_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Pentose-5-phosphate 3-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RPE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI37_2300p0010</name>
        <name evidence="22" type="ORF">CWI38_0085p0050</name>
        <name evidence="21" type="ORF">CWI38_0297p0020</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23 24" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FI-OER-3-3</strain>
            <strain evidence="21">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8"/>
    <dbReference type="EMBL" id="PITJ01002300">
        <property type="protein sequence ID" value="TBT97390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000297">
        <property type="protein sequence ID" value="TBU16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000085">
        <property type="protein sequence ID" value="TBU20355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY21"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2300p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0085p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0297p0020"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBT97390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU20355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="213" mass="24496" checksum="6B81EEB31ED04B35" modified="2019-07-31" version="1">MKEVSISILNCNLLDVNKELDNLETLGVEHLHLDILDTSFTENISFGPDFINQILERDFIIDLHFMIENPLKILSKINLKRVYTVIIHQEINANKYDIFEYLRLNRCRSGIALNPETKAEEIEKYLPLIDFVLIMTVNPGFGGQKFMKNCLEKIEKIKKMNKNILIGVDGGVTCETIQMMKGVNQVVVGSYFFKSTDKKAVLNDLKQAFEHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY90</accession>
    <name>A0A4V2JY90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0135p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000135">
        <property type="protein sequence ID" value="TBU20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0135p0020"/>
    <dbReference type="OrthoDB" id="2186465at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38066" checksum="311FC39D2F1DCDBE" modified="2019-07-31" version="1">MTTYSYEEVYEILKNGCDKPADLNFDEMIMLDHPEEPHIYKKLTESEEIAYKDKKYGISSFIPKKVPNYKRRQDNATFNDESVWNVDLTSETSGSFDAKGMFIASKAVEDISFENLDCCWLLKDSNKKILGPFVSNEMEEKMKNNLLDNFYLKRECDKIFLPFVTLKEKFSNPFTVEKNIVDNFFTESELQQNLKTLKISDKNEQTPKKKPAKNIVKKEKNIEDELSESEIKKILENCKKSQNFLIKRNVKIGLDEIRSNLIKMKKEMGLSWLARTTSMNNIECNDFLELLIEESKIRICLDIDKDGFLIINETDFKSKKTPKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY95</accession>
    <name>A0A4V2JY95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0100p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000100">
        <property type="protein sequence ID" value="TBU20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0100p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="858" mass="100629" checksum="EAB15130C7E9007F" modified="2019-07-31" version="1">MLRNNEPSFYCKFDKKKEKNQEIRKIYSSKYWYIIEILSKIFIFFKFLSLIDCFDIEVIFSDDAENLQLYENPESGFSGNIDNTSNICCRDTIGMPKTKAKDVSIAKNTLNNVYEKDCVSIDSGKGRKERQNANNKRKFDSDMSKSKKTYVTINEKAESTLDHDQYQPLDLSCKKKFKLAEQNEDKNKEWIIISQNSLVFDYSDEFKIRSEYFDAAINPKYSIRNFTKLKIDIQTFEIFLYVLRFGYDIKFLELETEKFKVFLKLFYDLQCYAESDIIRNLYKNMFSGLRNNNGSLDKNICKKKYENILIPNFLYLTFLNALFDTIDVKYDENTKELSFLKRTNQKKLNSFDRKEINEIIIRTTPEILMLLNDDSDNNIVLLKQLISNFKINGIKISHDNIYYSESAYNNNASMYENSIETLFSISQIKYLQIKFLQLERVNISDTDKIKIQKLEKLESLIFYKCAISPGCPFLTKIFFNHKNLVTLKICGFVLSLAFFKNLNSSKIESLDFSYSSFDKSSSRDWVSSIGLNSLRELWLDNSDLGYKVLKFLLISKKLEFLSWKNADLNDYNFGKTCFFPWRDLNKNVSNVNSGCFQLKILLLHNINLPFLLEILKQSFLHSSTQTLALSKCSVNSAVMESLKEFTHLKTLKLCDLTQGLKFSSDRKYLFEYSLISIDISNSEFIQGDITIFLKQFKCLKKLRISNSKHKKEILELIAVDSNFFSLEELDIAKNIFSVYELDRLSQMKNLKCLLITLDNSIYKDFVNQMGKMYFENMNKLVFINTDITKEIFQLIMEQTSLIDLSFVNSKLTNDFFPISILVSLEKLKHIYFINSTISTEIKRKLMCLKFYDITVSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVB6</accession>
    <name>A0A4V6MVB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0653p0020</name>
        <name evidence="6" type="ORF">CWI38_0709p0030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000653">
        <property type="protein sequence ID" value="TBU01682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000709">
        <property type="protein sequence ID" value="TBU12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVB6"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0653p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0709p0030"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="128" mass="14292" checksum="E5AC4733CA0B775F" modified="2019-07-31" version="1">MMNPLAATCKAINNANRIGKRSVLLRTSTNMTSAFLELMLKHQYISSLTYINDHRNNKVIVSLNGRLNKCGAICPNYNIKVSDVEGFRNRILPARQFGHLVITSTKGVIDHNTAIQEHTGGKVLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L5L9</accession>
    <name>A0A4Q9L5L9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0546p0010</name>
        <name evidence="3" type="ORF">CWI38_0549p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000546">
        <property type="protein sequence ID" value="TBU02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000549">
        <property type="protein sequence ID" value="TBU13044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L5L9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0546p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0549p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="170" mass="19846" checksum="8530752AAC9AA40B" modified="2019-07-31" version="1">MSFWRTKTFRISTIIVLGLIIVGLLIGGIGYYKATNAIKDSERDFKNVSKTEQFKNHLSKFKRKHSIKDIYNAVKIFDNELNRQLNFKQRTFLVLEIIDVKNIIVYKLHMKHGENTFLGVSTSLTFESLKINDEVYYVSDFITYIAEKVYKEATTDAILNEFKKIFNINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6R0</accession>
    <name>A0A4Q9L6R0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0315p0030</name>
        <name evidence="3" type="ORF">CWI38_0279p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000315">
        <property type="protein sequence ID" value="TBU03317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000279">
        <property type="protein sequence ID" value="TBU17627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6R0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0315p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0279p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="363" mass="42616" checksum="8B0C38D20A9B5FAD" modified="2019-07-31" version="1">MITETLGNQEEFKIAKEATRNMFYNGFFPNFFHVLILLERRFRLYFLGTNSLQYLLYFFIALLAFGIINIDCIYAKWREYSVQALLSIVLQIDHTNALQLRDFYFDSNELAIKREYERIIISVLLINAQSVFSSVFNGSVSHSFLNERNCIKREISVRSFTTISYYTSVLFYQIILNILSTGLFIGIFKLYFGDFLYSHFYLFSSISYFSFLPLLLLIGTIANNTAFPSILNMIFSLSTSISPHLLALMHFYLKKTAKFKYIKIFRIFALVPFYDIRYIFSMKCIDSIDKKIFSNSKYFPSLTWSLDKLKSVLGGFFEIEEIDIKLMTYLFFGITAAIIFVSIVLLNQYLRPEMRLKLQRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7R5</accession>
    <name>A0A4Q9L7R5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0383p0020</name>
        <name evidence="2" type="ORF">CWI38_0060p0050</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000383">
        <property type="protein sequence ID" value="TBU02961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7R5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0383p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="206" mass="24622" checksum="21CEA867F936BCFE" modified="2019-07-31" version="1">MYKDNDMTLSLVELFCVRKVFDCTTLQRFKKDILLPNLYLTRVKHVKKEDLLNEARESLYGIRLEEAYIYVCIYERLSTCTLARLKSILYLSRIMVAYDYNHYSTVFRVLYPDLHENMFKDCKLLFRIQELVKNCNGDTSRLEIIDILHVVTEEVQLNCILAEDELAYYSLLHDILEEKTVNMPNIFDYIDPVEYYSLYLNVTRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L891</accession>
    <name>A0A4Q9L891_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0229p0010</name>
        <name evidence="2" type="ORF">CWI38_0815p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000229">
        <property type="protein sequence ID" value="TBU03804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000815">
        <property type="protein sequence ID" value="TBU12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L891"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0229p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0815p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="162" mass="18948" checksum="67DCE1184BEF100D" modified="2019-07-31" version="1">MKQSFTINDIPQILKSLTDKQIYIENFTTEQIFYQLKDITDEIIKETEIFIKETETLSSNSFLNFINSTNQLDCKQSLNEENNHNIPINHNSNETIESNEHKSFEKTNHESNEETDKLIKKNKIENLLNKKTAKEILNFLDEEVECSISTDNSISSTYLNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8D1</accession>
    <name>A0A4Q9L8D1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0203p0030</name>
        <name evidence="8" type="ORF">CWI38_1269p0030</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01000203">
        <property type="protein sequence ID" value="TBU03969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001269">
        <property type="protein sequence ID" value="TBU11318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8D1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0203p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1269p0030"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000010">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU03969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="328" mass="36686" checksum="9931F281D9563ED1" modified="2019-07-31" version="1">MQPPKSVKDLARKTQQDITFDVPVSGHNFESDMDLQEFIKYFSNTGFQATNIGLAIKEIEKMKNSKIFFGCTSNIISSGLRDIIKYLIKNKFIHVFCTTGGGIEEDIIKTFNPTFLASFNIKGSHLRDSGYNRIGNLVIPNENYEIFEKWLVSLVDEITEGYSPENPLILTPSKLIKIFGEKINHQDSILYWASKNGINIYCPGITDGSIGDILTFHPKRECLKLDVIEDIYNLNREAFFQKSTGAIILGCGIIKHQILNANLFRNGLDFCVLVNTAEEYNGSDAGASIEEAISWGKVVPDNTAVKIFGDATIIFPILVAGSFYKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LB72</accession>
    <name>A0A4Q9LB72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA-like magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0159p0030</name>
        <name evidence="8" type="ORF">CWI38_0009p0020</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000159">
        <property type="protein sequence ID" value="TBU04281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LB72"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LB72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0159p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0020"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120553" evidence="6">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU04281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="468" mass="53566" checksum="39DF213089D9D28E" modified="2019-07-31" version="1">MIIVLFLCLKIFCTDKFCSKDSDCWAKSRPDIHSLYCVNNMCTKLLPPGRHCIKPTECASYFFYGPLACTAKCRVENECDTGIGKNIMSKYCCRSVPEGKDCINTRPQMLNGCDAKQMCLMDKQGEYKCESKNINFWIIGVILSISGNLMINVGLNFQKKSYSMEKVKFMNIELMLFHLGIMIYVLGKISGFTSYIFGNQSLLASLGAVGLIANSIFAPMINHEIFTWKDFLSIIFVLTGSSIIIMNSGRSHKVFSLCELLKMYKRKETMLWFIVIFVLIGTLFFAIKFFEVNGDWSIPNDFFNFLKKENVYYEEDGVILKYFMVLFYVGLSSIIASLTTLFAKSFGEMVDATISGDNQFLYGITYLFFIFLVFCTFLQIYWLNRALRHFDALLVIPVFHVIWTMFSVITAGIYFQDFEHYSVEQFKGFITGLLVIFLGSTFLASRVMNKGNICIKEVELEKQTVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCT2</accession>
    <name>A0A4Q9LCT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar sorting protein 9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2716p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002716">
        <property type="protein sequence ID" value="TBU05733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2716p0010"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23933" checksum="890A9ADC937C855E" modified="2019-07-31" version="1">MLYSWIESEHLEIKLDTCILNNSLINFSKLPFYRTPTEKINCYMKHIKFCYKEIGIEKGAEEILPILIYSIIKSDIHNVYIEKLFMNYYKHKNFNRCQHNCTHLNNNFLNFVEPKEICDCLDECMNNYNETTYYLALLDTAISFIERIEFKSLNISREEYNAFIDQKIISFKEPNKIIEISSQKDNKISKIIKYFRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDK4</accession>
    <name>A0A4Q9LDK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2673p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002673">
        <property type="protein sequence ID" value="TBU05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2673p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15220" checksum="00A4ECCFEFA85B0E" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISSKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH89</accession>
    <name>A0A4Q9LH89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0212p0050</name>
        <name evidence="2" type="ORF">CWI38_2501p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002501">
        <property type="protein sequence ID" value="TBU06825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000212">
        <property type="protein sequence ID" value="TBU19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0212p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2501p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14218" checksum="849FBA0CA6ABC162" modified="2019-07-31" version="1" fragment="single">KSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHI8</accession>
    <name>A0A4Q9LHI8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable lysine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2379p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="4"/>
    <dbReference type="EMBL" id="PITK01002379">
        <property type="protein sequence ID" value="TBU07593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHI8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2379p0020"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="179"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU07593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="514" mass="58980" checksum="2239F4BDEC278F02" modified="2019-07-31" version="1">MTENIQTPNTSTDEYYIKRSEKIKNDLENGINVYQHKFNVKNDIKSIISIYSDIEKGKTVEDEVCSSGRIMVIRNFGKTSFIKLMCDGLNIQLVVRIENKEDKINGVVKNLKRGDIIGYFGNPGRTSTGELSVFVSDIILLSPCLRTIPTEHFGIKDPELIYRKRHLDLLLNEESRKRFFIRSKVINFIRRYLDAKDFLEVETPMMNAIPGGAAAKPFVTYHNDLKAQLYMRISPELYLKTLVVGGIDRVYELGKQYRNEGVDLTHNPEFTSVEFYMAYADYEDLMDMTEELLNSMVKEIVGAESFSYHPLKRENRPDSVTLDFKKPFKRIYMLEELNKKLNLNLSGENLESKETLEILIGVCERENIRVGEPLTLTRILDKLCGVYLEPECVNPTFIIGHPRAMSPLAKKHRSIEGLTERFELFINCKEVVNAYTELNDPMDQRNRFVQQSVDKAAGDEEAMIMDEDFCQALEYGLPPTGGWGMGIDRLIMFLTNAANIRDVILFPAMKSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI70</accession>
    <name>A0A4Q9LI70_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2350p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002350">
        <property type="protein sequence ID" value="TBU07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI70"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LI70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2350p0010"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="406" mass="47599" checksum="2E96D5B41708ECF3" modified="2019-07-31" version="1">MDNCNIIKENDFVYFENKHDLKKIRKVSPKENIFVRKYKLNINTSKFIGLKYNEWYNINGEEFIEIETKGSMEIETKGSMEIETKGSMEIDTKGSMEIDTKGSMEIETKGSMEIDTTKSMETETKESIEIDTKGSMEIETKESIDIINPDILDNSDTEVNELDVQLEPNKRVKSTFTVAKYELKKKDKKSRQFIIYKVEPSTLLEFLRNKSASKIHYFTHPELAYISMFGSPYTKTLLFDNCQDLITYTFIYKYGNYNIECIKSSKKKIEKTTTPDENNSKITKIEKKHENSVERTIKYTNSTIKTFDLYTDILNKYSLVIICSRQDIIKILQFYDKNITNNLIIRTNLKEYGNEIFDYLLKSNIYINIKMSEFLFREYQTQHVHPLFRGNFSGFVLTATKINKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI98</accession>
    <name>A0A4Q9LI98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2430p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002430">
        <property type="protein sequence ID" value="TBU07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI98"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LI98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2430p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="845" mass="93551" checksum="DE6A7F5F8EA49348" modified="2019-07-31" version="1" fragment="single">NTISTYLLISNTLLLTNHLLNTYNTLKNRHSFLLTGVNKILLFKEEVNNLNILLKEKCLRLSQLKVESTNNITDLINEKEKVNNTIKEIISVNKDIKNNICYSLSKRKVISKEIKGVKDNIDSVIRDIKGVDKKSVSELKSMNNPPLVIKKVLSGVVGVLEGDSSMIEGYSSMMEGDKGSSIMKGVKGYSMMEGVKGYRDSSMMEGFEGSRDSSMMEGVKGSRDSSMMEGVKGSRDSSMMEGVKGSSDIKGLSEVYDKQQGVNDSSTNIKGVSKSTIKQQGVNISTNKQRGVKSREWREVISIVRREDFIARIVNYRDLLEDGLEEGDMLEDGLEEELEGVSDKDILEGVSDSSMLEGVSDSSMLEGVNVNTHNNTPLTNNSNNTPLINNTTNTPLINNTTNTPLTNTPLTNNPFTPLIPLAYKASTACGPLCKWLSSTLDYIQITSKLKPFIKELKNINNSIINNKRVLNNKQECLKLKEEKVLQLKEELRVKSCSVITYEKEMEEIKGRMCVMEECIGVMEEEVGRWSVEIGCVRDKGGSNSSRDRGSVLEGVNNSIDDYKCNSSRDMLEGVSNMEYDYKGDINKDSSREAVINKDGIREGVNNMEYDYKGVSNKDSSSGNEQRGVNNSTNNYYPLNNSTNNYHPLNNSTNNYHPLNNSTNNYHPLNNSTIDINIPYLTNLLNLLNNNTYMDNSVISYIRNTYYKLRGVSNINTNDLNILLENKRVIYIYDKEGVITKEVTRNNKKMRCSVIGKGNSSGGISTYSVSNNLSGNTPLGSNSNNNSGNTPLGSNNNNYCGNTPLGSNNNDYCGNTPLGSSNNNYSGNTPLGSNNNNYSGNTPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIS9</accession>
    <name>A0A4Q9LIS9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2569p0010</name>
        <name evidence="3" type="ORF">CWI38_2360p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002569">
        <property type="protein sequence ID" value="TBT97014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002360">
        <property type="protein sequence ID" value="TBU07726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2569p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2360p0010"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAMYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="296" mass="35360" checksum="7EF12C0D945C7943" modified="2019-07-31" version="1">MQITVYRKFEGCFKIIEENYEKRKDLFTKYTLEDLKDWKKLDLYFILDLEFLRDKKIEDSVLKHAYRRRILKYHPDTGKYGKEAFLAIKNAYTTLLNPVLRKQYDSFYFDDTLPLNKDYTEEEFYEVFGEAFKRNSKFSVIQPVPSLGNQSTSLQEIENFYKFWKNFETWRTFSWLEDEETESVCESTRNPTKLSKGKIKKIQTEYIFNIKNFTDLSIKKDPRLNKNTNNSSTHTCLITDGWTENEIKTLIKLLKENKGKDALQTVNTKFYKETGIKKSTKEVLVKCIEIKRVIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLU1</accession>
    <name>A0A4Q9LLU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2261p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002261">
        <property type="protein sequence ID" value="TBU08445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2261p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="9743" checksum="540FDD2477789ADC" modified="2019-07-31" version="1">MGGDIVYSIKIKGVNYNSSKNNRVGDIVYSIKIKGVNYNSSKNNRVLNINSSKIKGDKYIDSKITGVILGVSNTYKYNRVLNIRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMT1</accession>
    <name>A0A4Q9LMT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2248p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002248">
        <property type="protein sequence ID" value="TBU08540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2248p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13762" checksum="9C80ADEDCEAA9DEB" modified="2019-07-31" version="1" fragment="single">MLSISLLITTYILTSSLTSVTFYILNEENRVKNLINTDLTIDMMFLDENIEYFDKNNKITIFKNNILRHESKFEITSYYIPHTLTLPYSHGIFLNSALLKSLFDSREKNIRVFINDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP85</accession>
    <name>A0A4Q9LP85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maf1-like regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1885p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001885">
        <property type="protein sequence ID" value="TBU10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP85"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1885p0020"/>
    <dbReference type="OrthoDB" id="10661360at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="25217" checksum="6D4965204D34A58D" modified="2019-07-31" version="1">MRYLEVPCISKCNQILRSLEYLNPSLSLFTEMYSCKKTRKQKKEEIFMKNKICTNYSPNQSLISENNANNSLTFENNIPNNTPHNIPNNIPNNIPHTSSSKTSLLLSFTSIINLSFPEYGFHNFDESFFEKKNFSELKTSITNYITMSTKHSQITETIDIIFLNIDKDICFKDCIIYSLENRIAPYENTVWFFCYFLVNKSLKRILLMSGSQEKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ3</accession>
    <name>A0A4Q9LPJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1895p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001895">
        <property type="protein sequence ID" value="TBU10264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1895p0020"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="23646" checksum="32F5733B65A6842B" modified="2019-07-31" version="1" fragment="single">MYDTYNLEGKFFKLSAEDLENIVEKKTIFIPNLINNIEDLGSLLYRNLKNGSLELDKEHLLIYESSLVSKNDLDLSNIEKIYQNYNLYRYGNNENTIENKRSFWSILINNMNDKTLFLLLFASIMSFVVGAYKIINFSEKYSWIEGTSILVAVIVIVLIGTLNEYSQENLFGKMDKKNTDYNVKVFCNNAFDTKKSSKLMTGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPT2</accession>
    <name>A0A4Q9LPT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit alpha of mRNA-capping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1942p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001942">
        <property type="protein sequence ID" value="TBU10207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1942p0010"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="2">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="328" mass="39215" checksum="0FD25FA8A0EEED05" modified="2019-07-31" version="1" fragment="single">MLSLEDVGKKVDEKEKFKIYKKIIEKLNYPFIETLYAKFFGSHPVTLSNETIELLINRDYYVCEKSDGIRVLLYIYNDNKFVYSFFFDRKNDFYLVNINNNIKIGTYLFDGELYNDFGKNSSEIVFSIFDCLIYEGNDFSFQNLQKRLELCQNFINLYKNVDGFKKYKFKIQVKQMFKSYGFYQVYSEIDNLAHKNDGLIFTPVYQPYVFGRCYTLLKWKPPSLNTVDFLLRKNKEVKNCYELLCFGKNNEMIIFDHFFDFEIEEDRGRNVKESNKIKESNINMKNDLYRGEKDGERDGNQNIIPEDKNKGDMKKDKEDRQRDGNQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPW3</accession>
    <name>A0A4Q9LPW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LsmAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1795p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001795">
        <property type="protein sequence ID" value="TBU10394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPW3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1795p0020"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="282" mass="33299" checksum="10C1DD949B87FA26" modified="2019-07-31" version="1" fragment="single">MFREFLKSNILVNFLTDIFKKKKNEKEASEPMKSATKIFIKIRTITDDEIIGNLKNFNNNLIDLSDAYFVTNPKLIFPTLVIRMEDSLKISEIQENEGFFIDGDFMGKKEDKKSDLVHFECKNGESESFNVKESKNWDQFKANEQLFGIKSSFDESQYTVVLDKNSEFYKKNVEHAKKLAQEILSKKCTDRHRMEERGHFYDINEEEKYSSVLNDRKKRNGLIKKKETFRKESLRNGESKDYPHRPSSPIKENFRKESTRNGESKDYPHRPSSPIKENFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPW8</accession>
    <name>A0A4Q9LPW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1913p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001913">
        <property type="protein sequence ID" value="TBU10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1913p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21896" checksum="0C59E8B7CB6A6229" modified="2019-07-31" version="1">MFAKNLNFSFNGITKNIPYTYQSLTSTLIKYKYDFLSVKIFSEVETPNENIDKSKMIKLFNEAFGRNTYYLFGNYNLYIIDTIGSVLYEEDTLIRKTTLKTAMKQYIISFGFSCDPALYEDIILSYPLRNFEFKSFSHNTEFHYFLSLKTKEDYDYKFKIYLKHSYITFEFNFNWCNAEQTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPY0</accession>
    <name>A0A4Q9LPY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2017p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002017">
        <property type="protein sequence ID" value="TBU10106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2017p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="22693" checksum="FC7C7F06DE766BD9" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEILKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPLPSQTCSKMQNSGLDTLPSPNAPFPFSVEVSACEPSYDMTNPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFLQMPRNGWTELHKYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLIDTTEYINLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ24</accession>
    <name>A0A4Q9LQ24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5098 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1862p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001862">
        <property type="protein sequence ID" value="TBU10307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1862p0020"/>
    <dbReference type="OrthoDB" id="2193759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031505">
        <property type="entry name" value="DUF5098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17023">
        <property type="entry name" value="DUF5098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="58345" checksum="D74FE3349933B883" modified="2019-07-31" version="1">MDQSSVLNGKINILYEKLNWLKHFFEHTSVYVQRSADLLFRATQIPRDSSWHDSYILDLVESTDQKRKLCDELYKILDITIIKDINKIIEDVKELQTSMYKDSECINKVISVHLDYVNDKKKNHLNAWLDMKCDPWTTERELKSAISKFITEKEKVQMEVKSKVCKYAGVFEKINEEYNDLFLNFFKIFMNHHVSVGEVFERFVCVKRKNFSETFYDFEESDTSKNSSESEELIHKECSRMFVVQKEALEGDCNFGAKNNLLFPYQENDRLTENIRLAFDAVIEEVSSEVYKTKQERISKDIKIRKYGIFRYKKGYGNEWKVANVILTENDFLHAADFETILDLNQTLKDKYANFIKILLNVDSRDFLGSNEQNETVCEKICQDILKSDCFEKASLKGFPLNIKMMNFRINKQKYEIYLEFKKLSSFADLFISRNIKLRPFILKDAYDLYFGLSNSLVKTVKNEEIKEERNNGNELADVALKLEEYTEENPWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL9</accession>
    <name>A0A4Q9LQL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit Sec66 of preprotein translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1711p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001711">
        <property type="protein sequence ID" value="TBU10507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1711p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020542394" evidence="1">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="26783" checksum="3D9A194EFDC565D9" modified="2019-07-31" version="1">MLQIIFVCLSLTIVTLSYVKSKNKNTVTPLVGQNTELEKFYILQDQGANHNILMKQLQAAALFVTENVIRLSEERSVLYDLYSERMISYLQWKNIEKTLSRLSFEKMSIESEVEALKNGWSSKMFGDCEKEVSKNLLVSDKLKKENRNNEDSFYLRKREVLEREVVRRLKENNREEVLREIGRIKGIESYRGVRMIRRIKGIESYRGVRMIGIIKGIEVRVLVIREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQU1</accession>
    <name>A0A4Q9LQU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Importin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2079p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002079">
        <property type="protein sequence ID" value="TBU09981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2079p0010"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10505" checksum="A03538278F9B56A9" modified="2019-07-31" version="1" fragment="single">MDTSSLRSVFLDTLSPDNTKRTTASDRLLSLQKNHAFILHLPTSFMQDTDQSVKRIAALYFKNSISHEFASFSPEEQDQLLNAVFINISDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR12</accession>
    <name>A0A4Q9LR12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1528p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001528">
        <property type="protein sequence ID" value="TBU10824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR12"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1528p0010"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="23269" checksum="65D24BB8C82D5AE8" modified="2019-07-31" version="1" fragment="single">MYKIEEVRKIHNSDIKDVSVLDDYIATSSRDGSVKVTNINFSLNIERFPNCGYVNSLKLFKDSILSLFCGCQNGALVFYEDILNNENPIFFLGHNQNICSVDVYNKYVISSSWDCSVKIWDIISHTEVYNLIHEQTVWDSKFISETKFVTVCADKIIRIFEKSSVIQQFSYHVECIRSVFVNEKYIFSVSNAGKVIKSDFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI1</accession>
    <name>A0A4Q9LRI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1338p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001338">
        <property type="protein sequence ID" value="TBU11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1338p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="28365" checksum="79D045D83D05BD44" modified="2019-07-31" version="1" fragment="single">MNIEHTKIFKIPFGSLHCTNNFYAIIQSKEILIFNYPIKFIKKYIFKQKLLKVNVSKNEIIFVFESYVILYKSDNIVDDNEYYIEDGYIFYRSICIYNLRDTIEKYIGVKFGLDGMNNKLYYFFNNLMHEVELCRIDIENLCIYYDRYVEIEGRKIGCRISKNGILKIFNENVAISDTYCIKINAIEKNINFLVENFYFFKENLLFINEKFISIRNMKLIEVKRMEYLFFKMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ8</accession>
    <name>A0A4Q9LRJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit 9 of transcription initiation factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1886p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001886">
        <property type="protein sequence ID" value="TBU10271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1886p0010"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15486" checksum="D7BCF0C4C79402E5" modified="2019-07-31" version="1">MAAENQAPRDAKVVSLILRSLGIEECEPKVIIQLLEFAYKYSTEILLDAVLYAEHANRKNVTSVDIKLSLQTKVGRHFVPPPPKQYMNEIAVTVNSRPLLMYEDEILLQVPPAKLALFGLEYSVIKKDSETKRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM6</accession>
    <name>A0A4Q9LRM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1965p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001965">
        <property type="protein sequence ID" value="TBU10175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1965p0010"/>
    <dbReference type="OrthoDB" id="2196169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14941" checksum="6B9AF1E7E6789ED6" modified="2019-07-31" version="1" fragment="single">NKENFKKEVKLNKKINKEGKTDYKVIKEINDLNDKKLGIEISFYPKIYDSIHTSLNNSEFYFSKNISTQIYKLLSTNKMKLEDLKKYICKENCKENGEEAFLKHINSLIFYGIVVYKNEFLYIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY2</accession>
    <name>A0A4Q9LRY2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1324p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001324">
        <property type="protein sequence ID" value="TBU11204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1324p0020"/>
    <dbReference type="OrthoDB" id="2189774at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="494"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="668"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1515" mass="170696" checksum="F53CC3339CE5D142" modified="2019-07-31" version="1">MHNKPNPDERKKNLIKLFNALKSSPFSNTHALEQIREAAIKAEQISFEQSKTIEEYLYKMNEKYCKITKMTQNPTHMHSSKQTESNYNISESSTKSSTSSNSSNPYIANPSNPYIANPSNPYNPSNPSNPYIANPSNPSNPYNTTNPSNSSNPYTTNPSNPYIANPSAHPPNPSNPSNPSTPYTDTFSIPRHPLQNNFHPQQIFYNQNNSSYNNSQPLHANIPFYTVSGSRSHLSNINNIKKGFYTGNSNSGANSSVNSINCGVSSSGSANGINSSVNGNNSSVNGNNNSVNNNGNPYTTSNTNPYNTNNTNPYNNTNYNTNQYGSKPNPYTTYPYNNIYPNPSPNPNQCINNTSNNPINTNPYNNTLTNNTPYSINPYSTNNNLYSHINNTSISLSNQLYKQNPNINTEHIMNNSNYYPVFNSNISKKTRYFKSKINPVNVEIKRNSNYLKGSEEGGDNCSGNGYGNNGYGGSINNTPYNSAGNNTSYNSAGNNTPNSNTYNSNPNSNTYNNTPNSNTYNNTPLNTNPYNNTNPNSNTYNNTPYSNTTNNTPLNTTPYNNTNPNPTIINTSNTTNPNTTTINTPLNTNHNTTNINTPFIYQHNTINRHPSIFNEMPEFLRYNDIPQESNKTIKTVKSPVIKIDRQHMYSKEGVKYTEQEIKHNNEINSNNGSYSNNGYNSTVNNTSSTNPYNNTPLNNTTTNPYSNTPLNNTTPYNNTPLNNTSTNPYNNTPLNNTSTNPYNNTPLNNNTTNPYSNTPLNNTNTPYSNTPLNNRIERDIYNTNYRQNISQQQDTNTITSPRKRGRKSKLSPSLKKIQNISSYSENNLDSKDNGVSSSNSSVNMFDRIMGNHFDTTRGVNNKDSSLKGVSSNYYTGNDLYGSNTSTSQYNNTSLFTNGINNTPSTNPYNNTTTNPYNNTPSTNPHNNTSSTNPYTNTPSTNPYNNTPITNPNLLNTSQYNNTPTNPYNNTPYNSTFISTKNKVVICKKVEEIKEEETWKLQEKNLSRSLTSQDKRVDNIETVTKKVELKVVELSRKEIVEKVLKEIEDLEEEYGGYKDYCGDNDGEDSEGEGEGILTPDDLMDRLIEERRVFFEEGIGIKMVKGFNIIEEGDNDIEDGLEGVSDKDNRGDDVSSKEEGVSDREGVLESVSNTIDKLEGFGDKDMLEGVNNTIDYLEGVSNCTIIQHSFNNTTNTLHSFNNTTITLHPFNNTTNTLHPFTNPIPILKSLEYKPNITSESIEYEIKKEKELTPHEKYKLLTNKIEDGSVITSDTYFLSNKIFGFKIKLKKQQISDEESNKEIYLNTNQETCGEKCEDIRDIRDIKDINYIKDIKDINYIKDINKTDINKTDTYKTDINNTDIKDDKLEDIHSKVEWLNAFVRKNKKDLSEEEKKEIILKINLNKNSLIKMENVRVQFINLCGKNEEYFKFLRVKCVLEKQAFCVKEEFYFLDDKTVRALFEYLKELNALLIKEIEKSSVKMCDKGEISFRKCVMSAVSKFEGGGEDGLNVLLLSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS31</accession>
    <name>A0A4Q9LS31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0027p0090</name>
        <name evidence="1" type="ORF">CWI38_1722p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001722">
        <property type="protein sequence ID" value="TBU10491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1722p0010"/>
    <dbReference type="OrthoDB" id="2186631at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15832" checksum="F3E75CC972F27357" modified="2019-07-31" version="1">MNRAVESYFFDCKPIKKEQTDKILNILKDSNSYLTHHGELLTIYEPPLFNLYIDRNSMRRVSYVFIFQDNIDHCALFQSVREFALRNNIELYKFPKGTSKDIRKICNKKTNVNIIATFEDDPITVEIKKMFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS87</accession>
    <name>A0A4Q9LS87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1456p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001456">
        <property type="protein sequence ID" value="TBU10966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1456p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="21943" checksum="8CB56049F53EDA7E" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKTKAANDADEVKKSDSEVQKCKLHPPAISLPPSSYTTITPPPPSQTCSKMQNIPSLVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEEKGERRRIATCLADTSTLTDTMEYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS93</accession>
    <name>A0A4Q9LS93_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1676p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001676">
        <property type="protein sequence ID" value="TBU10571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS93"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1676p0020"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="268" mass="30636" checksum="F3FC3620CC86E487" modified="2019-07-31" version="1" fragment="single">MENYLNALLTDVMLKEEEIGDICDKACEILLNEPNMVNVPSPVLICGDIHGQYYDLLTIFKINGTPKSRKYIFLGDYVDRGANGLECFCLLLVYKIMYPSNIFLIRGNHESKDLTKIYGFYDEVAKKYGNSRVWRYCCDVFECLINACLVNGRIFCVHGGLSPSLLDIDEINRIYRLNKLPDNHFVNDLMWSDPDELNPGFSKNSRGAGYTFGSEVTKKFLEINNLTMLVRSHQLAFTGYQMHFKEKCAVTVWSAPNYCYRCGNLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT46</accession>
    <name>A0A4Q9LT46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1480p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001480">
        <property type="protein sequence ID" value="TBU10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT46"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1480p0020"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="35285" checksum="71AED4CCB93CB36C" modified="2019-07-31" version="1">MGNKDYYKVLNVSKTATPEQIKAAYRKLTLKLHPDRHPNATEEEKKKLNTQFMEVNEAYHVLKDTEKRKNYDRFGTSDPQFTNSNFDFESFGNFPNFKFSSFKNFGSENIFGSENIFESFFDTHDTRKGKQKNAVEFVLKCTLDDLFSGCKKKYKIRRKLLSSTQTENNLEVVVKPGYKKGTKFKFKDQGDQLNDGSFQDVHILLDEVPDPVFTRNGNDLEMEIRITFKEFICGFSRNLILPGKRRFRLEEGYITRIGDWCVINGLGMPLSKEPSRMGNLKVKVFVEDIPKLTPSQRQRMASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTB0</accession>
    <name>A0A4Q9LTB0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_1448p0020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="PITK01001448">
        <property type="protein sequence ID" value="TBU10981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTB0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1448p0020"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000021">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="15">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="177"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="528"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="12">
        <location>
            <begin position="657"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="971"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU10981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1171" mass="133125" checksum="00D8B766D5DB87B6" modified="2019-07-31" version="1">MDKNTAASKLVESFLKEKGLVRQHIDSFNYFIQYDIKNILKANEILDSDVDQTFYLKYTDIRVGMPTIEENMVAYEIYPHECRLRDMTYAANIYVDVEYVRNKQIVIKKDVCIGKIPIMLRSKRCYISIKTKTNVILSKETENTLYRKLQECPLDTGGYFIVKGVERVILIQEQLSKNRIIVDLDAKGNICASVTSSTHDKKSKTVVVTKNHSLYVKHNSFIEEIPLVVVVRAMGLSTDKEIAEGVGCEEEVLEYFAPSIEMCHRLGIFTEIQAIEYIGNRIRVKYNQDKIEEAKCILNEIILPNVIITDLNYKIKGLYILIMARRLIQAQLGILSLDDRDFIGNKRFELAGQLLSLMFEDLFKRYNSELKKSIDKVLSKISRAQEFDALTFMSLQVNLITTAFVRAISTGNWTLKRFRMERSGITQVLSRLSYISALGMMTRICSQFEKTRKISGPRSLHTSYWGYLCPSDTPEGESCGLVKNLALLAEITTDSPYEDVLKLLFTLGMEDINILVPKLFYMKNTYLVFLNGMVVGVIQSPDSFIQTFKKIRRKGGVNGFVSIYKNEPQKTVNISTDNGRICRPLLIVENGRVLFTQEDGRYLKEGYKTFDTFVNEGKIEFLDANEENDSLIATIYTDLCSDTTHLEIQAYTILGYVAGLIPNPHHNQSPRNTYQCAMGKQAMGVIGYNQYRRFDTLLYLLTYPQKPLARTKTIELINFEKLPAGQNAMVAVMGFSGYDIEDALILNKSSLDRGFGRCEVYRSFSSSLKRYANGSYDVLSKGDNSYKNSVLDLDGLSKPGEIINDGQIYVNKYSPVSNESNIPEYKFTGLVYRNSEPSVVDKVIVTKSGEDLLMVKTLLRQVRRPEIGDKFSSRHGQKGVIGMIFEQQDMPFNEFGMCPDIIMNPHGFPSRMTVGKIIELLSGKCATLSGEFVDSSAFNNFKKYEEFHDLNKNLEHLEKNMNLGAEKETFRSKNIESIDDLENKVKSAEKKLGNIKIESKEDSDSENTCVNKVDEISDYLVKNGFSYSGKDCFTCGNSGRQIEAYIFYGPVYYQKLKHMVTDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASSLLIERLMVSSDAFQAYICHECGIIVHKDGCVMCDGEPVCIQIPYACKLLFQELMAMNIYPKFKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK5</accession>
    <name>A0A4Q9LTK5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1490p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001490">
        <property type="protein sequence ID" value="TBU10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1490p0010"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="39469" checksum="723454853D89E2FF" modified="2019-07-31" version="1">MKSRQCWICLMNEEETLQDTEFMKYVDKKEIWVRPCKCTGATQWIHKYCFMRYIENRWPTNNRCSFCKVEYVIISRNYLYIFFYEKISEFIAKILTITSLVFMVMATYICLFSYGFSVFIIFMGFKESIDLLFYEEDGSFFPYTGNLLRVFMGAPLIPITMIYTSYVKFSFTFHILPSLIILNYSKMNFSNAATSLLPLTFFIYKKIINNLKNKLKSIYRTGTGNTYQSEIVFNNQVIPLKAVMSCLISPYMASFLGYLFFNQKFIGIEQSLMGGVLYVGIKDLLSITYLIFLKRRSKNIKIMDQGGDEIKENTGDGFEDNNNDSFNEEILIEGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY3</accession>
    <name>A0A4Q9LTY3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0899p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000899">
        <property type="protein sequence ID" value="TBU12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0899p0010"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="19372" checksum="A401B8A9C7D7B138" modified="2019-07-31" version="1">MEFYDLNLILAEETKVTVKFNHDVDFFGFYFAENLSYIPKNHSVKVPFFMVDFLLENEHCILVDDFLEETTKNNLMAKPSLVNLSENYFNFYYFGIIISKYLNIKDFLFEVFCERTSDFCNELFTDKLTDDNYLLMDINEKRIMFFSAFILEKYRRFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU28</accession>
    <name>A0A4Q9LU28_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0928p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000928">
        <property type="protein sequence ID" value="TBU12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0928p0020"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="32112" checksum="3E17179E836489EC" modified="2019-07-31" version="1">MFSKISYYRNNFYILSGTHIIILDSNANELKRINHELEVVFIKYNYLIDRNKCLYKLENLNLKFICTIKKMISNMFKDNEDIYLVDRFGDIYKIYESTVVFVCGNMCFTTGILIYNDHIISSDKYGRIKIYHNIHKKILNYLFLFNSPITSLDMNNDFIIASEINGNIKVLDITNMNELTFHKIEDIKILKKIIVLNKKLMVLCDKGTFVFEIDVNGKLIFLKKYDFEMIDSIIENNNLLFIDIDNMLWFNDIKVLETIQSTDDYIGFLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA4</accession>
    <name>A0A4Q9LUA4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0841p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000841">
        <property type="protein sequence ID" value="TBU12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0841p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="97677" checksum="C40B6A9E61AFCD03" modified="2019-07-31" version="1">MYISICFRRICSLNHEENIEMRCLRKIIWMIAYSRWIALLYFFGFLKAVNCTSRSNNGRIKFALIDMNWRNAISKQDLAAVEYWMSRSNSMEKFCFCYGKHFFQENKIYPAFFICTRGLSFLNHEPLHIFEVNYVDDWKIKFRILDDYLVQKSRKPFLFKGPLSVSYQLFNIFVTYLSFDSTISAHNLSYELFYKFLKLLDLLDPISSVFLNKFYSNLYKNGLMKASSFDIINDDKNYRLRYFCEKRRKRPFMYFFGVLNNYLGACLIPDISTLSVFKKRNQHIDQCFRYTEEVRRLVLKISVTSLELLICSLRINVHIFDWLLFVTKIAGYYIDDTEYSFNPIKFHNICGFVNFDGPIKTQNTLKVVSSDFFLNLSDVNQRRITYLRFVNVDICFDLIKPLLNRSRITFLEISYCNIAAGSKITDLSEIILRLNVLKLRDFKLRPDDIYLILHSKIKVLILSNCTLNDGSVFPFNLNKRYVYEIAKNLRMLDISSSKLPMLFVQFLCFSSNLENMNISCFEFLPEDSFSSLKYSYKKFDCLEINHYIPNDSLKCLLMKVSANSLSLCFSNAFNEVIYFFRAVALINSVKYLDLSDNILPSYFLNLVDYFKNLKRLKLSSSLPLYMNYINDLRIYNSLTDLDLSRNNITTHNYTFIPRFINLKSLNLMNTIIEKGLFRYILSNNLTNSLISLDISNVVLRFCDFKRILYCKKLKIFHFKISSNRPLSYYCDILSLTMAKNNLSILTVELETNINFDDILSLADFHNLLQVKITCNKFIGVGEEDLIKFNFKNPEFRFELVLKDYNLDINTVGILMEIFNNYSCSFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ5</accession>
    <name>A0A4Q9LUJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1075p0020</name>
        <name evidence="5" type="ORF">CWI38_1283p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001075">
        <property type="protein sequence ID" value="TBU00220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001283">
        <property type="protein sequence ID" value="TBU11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1075p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1283p0030"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="119" mass="13107" checksum="D01FBEACE6823281" modified="2019-07-31" version="1">MIPIASPLVNEKITGKIQKLLKVKRRAGVLKRGASACTKAILGGKNGFMVLGGDVSPLDLISHLPVLCEEKGVPYIFVNSKNDLCDASKRKLPSCCCFFSFDKEEEEDMKNILKYAFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK5</accession>
    <name>A0A4Q9LUK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1296p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001296">
        <property type="protein sequence ID" value="TBU11260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1296p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="31117" checksum="72FB75959F0B1649" modified="2019-07-31" version="1" fragment="single">MDKKSSKSKNIKIKEKQQNDNFEADMYREDVNNLNNKNIDSKNKIKKTNKRSEISLKKVEDKLKVNRNEEDENLNILKNDNKKSGKKLDKNHIYKENSISFDNIDYKLNNSLRNKDLEIEGAGEIRKYEKEKKDLKEERECEKSKTEKNKKIKNKKREQIENKNSTNTKEESENKKSKLEENQNTKTKEEKFKDTKYKTEDNIKAEIKKEESENRKSKTEDNIKAEIKKEESENRKSKTEDNIKAEIKKEESENRKSKTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL3</accession>
    <name>A0A4Q9LUL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1275p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001275">
        <property type="protein sequence ID" value="TBU11305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1275p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="24407" checksum="489A5065B589DA61" modified="2019-07-31" version="1" fragment="single">MLEIECRKKCRRSSSESDCFSDSKSSCSSSSKSCISWSDHHEDRRQNSFVNCDSRRKCEPCFPPPKKCFLPKPHKSHKPSPPCPPKPSPPCPPKPCPPCPPYPECPPCPPCPPCPPCPPIPACPTCPPIPACPPCPRSCPPIPECPPCPPYPECPPCPPWPCPRPPRPSPRPCPPWPCPPWPCPPWPCPRPPRPSPRPSPRPSPRPSPPCPQWPCPPWPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU0</accession>
    <name>A0A4Q9LUU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1161p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001161">
        <property type="protein sequence ID" value="TBU11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1161p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10853" checksum="CBAE6A41D24DAA3B" modified="2019-07-31" version="1">MKSVNERIKQICYQVNVDFFNYIPNKCSKRHIPNDDELLNRDNLERIVELIYDDSVRNISMSCNENYPNLLSEKVSKIMNCKEGSLRPKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV7</accession>
    <name>A0A4Q9LUV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0752p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000752">
        <property type="protein sequence ID" value="TBU12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0752p0010"/>
    <dbReference type="OrthoDB" id="2198293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="697" mass="83116" checksum="44E8C82EC82F1990" modified="2019-07-31" version="1">MKEEFNLFVKKINEKKSKQQPLIKYLNELELLLDKFDDTDRFQFLAILCLEYYNEQDFDKSKIYSKKAVAELLRILKTKVMEKEDILFAVNYLEKCVLVEINIEEYETGIFKKQIFEEKSKNEYFKYFLNYGTEIFNFLILENFLDLLYLHYNEDKIDFLIQKLGELFDKNKILRDPVLKTSVFHETLLINLVIIDQKNFHLYSEILRNMLIFRKNDLKDLSYILISLFKIEKTSFFKNIIDEFLKFKNLFTTVENNILNSLYTEFTKIINNTINLEILKQEYINSINILYFYFAKKEYEKVVSLYKKLSQFDKKKIPPNIIFKSLVKIKDFKSAEVILQEDINSKFKISEDSFSMEMSCEESDLSSENVFLYYILTNNNIGALNTIQKINDKNSFVKCLKKVYKYNVKQIIIAALGIGIQKFADDIEILMVYISYIHILEFEIQPEERAEIILKALKDTNLNEYSEKIREWFFTVLYNNVIDLLNTNNPMIFELLERCYEINSKNLGLIEITLYVFKQIKIKDKKKHIKQRIAILYEDFNKIIKLSKDQETDLIHEIFISFYHLILEFSLENQLLDLIPKLYPISKFSLENLKILLHTEISIPHNHTKIKISIINESYKRNILTVELFDKFIITSTFFGPISFYSFLSEVSLFIDIQEFISDFSKNIINTQSLLLKATGHYEIYEKLKNIYLGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC7</accession>
    <name>A0A4Q9LVC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0720p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000720">
        <property type="protein sequence ID" value="TBU12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0720p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="377" mass="44627" checksum="D19749F9D06F182A" modified="2019-07-31" version="1">MCNDITEKLKIATENKIKERVFPEIETQAVDTGKCYKMDSEKYYRLIPSNKSSSTVLNIFFQVFTSFIYKISGVILNDKLVDIFYLGINNIEINALDSLNIFKKIYIKQMLISNSTINGSILSLILGCNFLKTLKFFNIAIRFDINELKVDCNTSISKLIFYHKDTLNTEIFLTFVSFMRNLESLSLTFFNESIMQVRNNFTLVNKKRLKNLYLNVDSEISTFNDLYFIQYFVVTESLVFRLKYSRKFQNDFFDLLSDDLTHLNIGNLTFDEKNRRVLKNFKNLSCLRIFDCLFKMLHFNELFSSCFEYKLAEKDLNDINITIEDMLFMKKHTHLKKLYFKNCNFVLDSYLFLTKRNFMGLKCLRYESEINDSGFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI9</accession>
    <name>A0A4Q9LVI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0817p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000817">
        <property type="protein sequence ID" value="TBU12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0817p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="47198" checksum="1A281399E71059AC" modified="2019-07-31" version="1">MQEKFVALHPNPVTHHPTDSHFSKNQGTILDQGEAKTCLRVESTHKKPYSSYKIDDGSNFGDNSSFSTPEGVSHKISKNNNAPCLVYSHFISIDSPPEKLSSLELKNLLNHISNYSENMAIPDISIILDIDVLFDDILKEGIFAKYFLLARNLLIIEKNIINIDAIKKKEFEDLFKKNGKNMDLAAPETSIFYNIPLLFHLHKLLEVEIYSCTPHVKYYVRIAFCLKLVKSILIKTSEMIADILDPSKSTYIENIYFDRNFHKNFRIYNNLTVIIKIFTIICVNKSEILQGYLELFSAARECYKAKLPNNSCSEKNVFTDKNIWYLFDVMFRYEYFDISEIQFCSCIINPIKTYDNNKDPKKIIRNVTINNINNLYVALIKKVTNARLCFKLLDKKDKKDKKFSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK7</accession>
    <name>A0A4Q9LVK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sad1/UNC-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1202p0010</name>
        <name evidence="8" type="ORF">CWI38_0647p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001202">
        <property type="protein sequence ID" value="TBT99825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000647">
        <property type="protein sequence ID" value="TBU12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1202p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0647p0030"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="202" mass="23917" checksum="517EAA642C0BB49F" modified="2019-07-31" version="1">MSSEHIKRAETILNTKNDNYLMGKCKESFIIVRLCDEIKIKLIILQNLEWQASFPKSVKFSILNNQNWYEIGTFELLKKRSPQSFTLNSPHFSNILKIEILDFNGKFDIFTLSSLKVFGTTMMEDFKEKEFIKTQGMNLYDIFSSKIIKLEKYNELKENFIVFELEKEFLHLKKVVYKLKNCVLLILLLLLLSLIFILIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM1</accession>
    <name>A0A4Q9LVM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1096p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001096">
        <property type="protein sequence ID" value="TBU11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1096p0030"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="379" mass="45475" checksum="C3F4EDA2025D49DC" modified="2019-07-31" version="1">MSKNCYEKNFESQIEMLGFENVEFVAEGEHGYVFGAIDSINGKKQAIKVSKSKPSIENEINMLSGLEHSNIIKLLNVKKQNSTIFIFYDFYEKTLYKFVDKNKINQRKKKIIIKQLLDVLVYLNEKQIIHNDLNPNNIMIQNSYTVRVIDFGISCSKESPKNLFMSNLSEEDNKKYFHYSPEVRDLAQTFDEKTDIWSLGCVIYFIETKKKLTEYILEENLQEKYRKFISYFIHKDPSYRISAEIARMSDFFDDIYKQMFCFCCLRSKIYFLNEIEYRIENDILLFEREEFHYQIHCKHTTESIILYQEKLSVIRRNNQDFIKQNPNFEFSKKCKFLVYLNQTKYMLYELPIEHFCVVWQAFRLLKDQNISTGLKKHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV8</accession>
    <name>A0A4Q9LVV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0604p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000604">
        <property type="protein sequence ID" value="TBU12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0604p0020"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="489" mass="56983" checksum="678128399991EE93" modified="2019-07-31" version="1">MSVSYFHTYKSHIKGRWLNKPLQEALSSEFTHRPPSYYTNAIISQAITINDQPTNPDKILSSNDILYHTVHIHEPLPKQLKIIKIESEYLVLEKPFGVPCHPTTEYFHCSVSQSLKQFVYFEIFNNSEFLNKEFQSFNEKRNYLIDKNKNKTNDSESSTDNTNQNLYMKENYLIETNENNIKNSFSSTDNTNQNFNDKENYSINTKDIKTNDSFASTDNTNQNFNDKENYSINTKDINTNNSESLMNETDHIFLEKKDIKINNSESSINNTNQKFLEKDFPLLLNFNFATFNPKITLSCINRLDLPVSGILIIAFLNSQKYHKIIKNSSTKKFYVALVKGNFPNKISVNKKLKFVKGKKSFVDEQGKESFTDFYCLKRNKEYSLIECMPLTGRPHQIRAHLSSIGFPIINDIKYGYHQIPNESNDISFGCFTPLNHTQTHSKYRFAINNCKGIKSKSFRNYNEYICLHAYKYVFNGNTYECELPEWANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX9</accession>
    <name>A0A4Q9LVX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0761p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000761">
        <property type="protein sequence ID" value="TBU12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0761p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="13129" checksum="6A5BDC3D018AF7DF" modified="2019-07-31" version="1">MRYRLKLINKHTIRSNLTLQISTKIENIYDSKYSNTGIRFLGLKEKTKVHPNTNGNRAHIGDKRFGCVFDVATTKEAKTTNKFEQNIKKGKSSGKELLFRIVHKNLVKEYFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW49</accession>
    <name>A0A4Q9LW49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0918p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000918">
        <property type="protein sequence ID" value="TBU12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0918p0010"/>
    <dbReference type="OrthoDB" id="2194105at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="18336" checksum="4B09B27FE6FFBD03" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKTANDADELHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKDGLELFFLQMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW57</accession>
    <name>A0A4Q9LW57_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0977p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000977">
        <property type="protein sequence ID" value="TBU11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0977p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="26049" checksum="F7A0F403BB4D3138" modified="2019-07-31" version="1">MAKITKKAWIGIGIAGAILVVIGTFIGIGYAKAGTVLKNFEDDYKKVSESDSFKAILKDLKDKRLADFVSVKDSKYFQSSFVGSADEVKTVDEALRDKKLDDLKSYIDDHDPNASIQVDSSKFASVVGDIGFLAKLGFVFRSSGPLKSIRSVSEFINKIIKDDPKEKESMILAFISLADDKEAKITEVKVADDRKVSSIADGKTFKMEDKGESKRTPVDFVAFIAEKVKKQQATPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU3</accession>
    <name>A0A4Q9LWU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0633p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000633">
        <property type="protein sequence ID" value="TBU12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWU3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0633p0020"/>
    <dbReference type="OrthoDB" id="2195483at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="12808" checksum="3F8AE1351AAA82D4" modified="2019-07-31" version="1">MKSEPAYLSATAAWSRNISEVAAMNKYGMLSTARNFDSIFVMENARIHHSRGLNDDEEIALYRIKYLPPYSSFLNPIGNVITVWKNKMIRGGARTEPQLRILIREKFNEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV7</accession>
    <name>A0A4Q9LWV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0489p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000489">
        <property type="protein sequence ID" value="TBU13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0489p0020"/>
    <dbReference type="OrthoDB" id="7976214at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="197"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="41214" checksum="5105DEAE7AD480A1" modified="2019-07-31" version="1">MSNSFSGKNTNENKYDFHVGETPEYIECENDNVLKCLVETSGSHDENLSLSTIPTLRKQKISINDRERIIEKTLEGYSMSAIASMYRINYQTVNSIVRRYLKTGLVLVEKRGGDRRSKLTLEIKESLQTYGDFERKKPCMSWQNGLNVHLMLMCQLVQSIAHQGMSERRNTLSTIELRTNYATRFRELEVDNDDKNFVFLDEVGFAVVTRPSRGRNIRGESAYRNISVVAAMNKYGMIYHKIHERAVNDEDFKLSIKEINASCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVFSPQLRILICEKFNEITGEHCSSFYRKMLGYLQKAEVGQVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX50</accession>
    <name>A0A4Q9LX50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0592p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000592">
        <property type="protein sequence ID" value="TBU12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0592p0040"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="19583" checksum="56F344BF5E472CEC" modified="2019-07-31" version="1">MKYLLFLDRNNCKKLFFNLKILLNRSLKIVETEKLRKYDLLANDLGLIYKCNVDIILYVMTWDGIVTKYNKSHLKRLEIDMNVKAYIQSIVLKKTVETISFDRRRGLESRLYAEESWERALMSLIMRSEMHEEPTPPLKEAKREEDGAKNLKPKNSTPLISQGGADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD5</accession>
    <name>A0A4Q9LXD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0724p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000724">
        <property type="protein sequence ID" value="TBU12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0724p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18305" checksum="B80C75BCF051D921" modified="2019-07-31" version="1">MSNINLKYLMRDDSLFSNLWIISSNYPYIYLLPFYIDLGNVLIYRIFEYKFLYWKITGIIIEKTSNEPNSSSKTKNKGINSDSICLLNLEMNLFQVKIFNLSFTNKYISDNIFFLKISDSIIEYNGLNSLLRIPNLKKLYLYNIQFLGTEDNKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI0</accession>
    <name>A0A4Q9LXI0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0551p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000551">
        <property type="protein sequence ID" value="TBU13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0551p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="626" mass="71631" checksum="5AAC9246F4644019" modified="2019-07-31" version="1">MEIRNIVMKSKFLVILQTMWCSNIAESNNLILSNDFVANPERNDEVDLEENRKSIKIKNEKIYLKFKSELLKKDTTSVSKILHTSLNKSNKNFSQNPLSNKKGINNHYSYFERTDSRILNPKTRSDVSLKSNNSNLCSTSIDESDTETSNISSIYSSSDLSYDADIETSSDDFYPSLFKERHDDNNSANNSINCATENMNSALKKENISVDIVSETEAGVKSNLIEAENSDLQLIKEISPIHDSKNSKQNCLSTNKRSRLGYFKYILSSTYIYVNEFLKCRKLPSSKQKCEEVTTESVTSSNRMINNSSSVKTSLNNLLTTIKIKISFTRTKGAIFFNRSFERISKVYQSTQTYTIEFFHKINIVSSAVKKFLKIKDILYILKYIICISLNKSEGSQKSYDNTPSFLIEESVGLDDSIGLFTIDEDLDIFLKNIFKGFISKKKALKQMKSQFKEVMLNEFKNEIKNKNKISMSNFIERLNNKDTTLDIFITANFSDLVFTNHSNESDQNEKIELINKSSSPDQDINISKEVLDGNENVLTNFNISRTNDSFLLEDLNENTDNNSLLKLTFVNDALYIRKEKQALTELESSKQTHLEKNDNNISQKIDSENDMPVVIFLLSFLFITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN4</accession>
    <name>A0A4Q9LXN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0682p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000682">
        <property type="protein sequence ID" value="TBU12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0682p0020"/>
    <dbReference type="OrthoDB" id="2186070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="21103" checksum="B11DEAAA10E1E6BE" modified="2019-07-31" version="1">MTVTQILKTQYLKDIVIYNLLTNGIYNTNEIVNIIEINEYLRDISYEAIYWYDKSCIILKNTLFKSEHTHEYLKSNQIEEIKDFFKNILISDLSETNYKKYSMAKFLIQKRWIEIINGKAKMTKMCLIQNTEYLISITDKYTKCSLFDIIVLNRNTHEYCERIYKERICDNIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU7</accession>
    <name>A0A4Q9LXU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0503p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000503">
        <property type="protein sequence ID" value="TBU13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0503p0030"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="433" mass="48212" checksum="26BF5CF601883707" modified="2019-07-31" version="1">MVSNSISVNFISFKRLKGCPTDILIFGCYLVICGKHSSILVCDSKLKGGSVISMGCSVISMCCGNGCLYFGTSKGKVYVCSEEQFMVRVKDIIEDGEGGKGKGGNDCDRDNDCARGDIDGGKDIDRGDIDRGNREGMDKDNGEESTHITINNDINTNKDININIDINSNKDINNNKDINSNKDINKDINTNKDIDNNNNIKKDIGIKRYSNSLFMHFRSLKIGSCGVNSMMYCGKENGVVVGLANRKICLLRSGVALVRTFYGPKCPISYVCVSKGGLVMVIGTSYVKFYIFKKENHLSYKSTQGFIQCGGFYTEQRILVGTDTGYLLYFLISKSTPFLCKPIGFSITSIFLSKKNKCVLGTQNGFIYFFSVTDTDINVLVKAEVYGVVNFIKYFNKSYYVGCGRENRVGRWEVNKEYMNCVVRIKVEDKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ3</accession>
    <name>A0A4Q9LXZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0487p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000487">
        <property type="protein sequence ID" value="TBU13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0487p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13940" checksum="814DE34AE406DCBF" modified="2019-07-31" version="1">MVKYSLGEMVTRDNIEKKKGVLSVSYSSELLNNGKIGLRDEAVLFYIQDRNMFWLGKDYTRPEEILDNENLKPRWPIEPIPPLEQMSNDKERNDNKNICREARFRKIKYGSQTVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY98</accession>
    <name>A0A4Q9LY98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C13-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0666p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000666">
        <property type="protein sequence ID" value="TBU12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY98"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0666p0020"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="31441" checksum="B0E1D38FBC295A0F" modified="2019-07-31" version="1">MKYKIFFLIKYVLTKNIAILINGSRYFHNYRHTSNILAFYSALKQNGFEDTEILIVSYEDITKDPRNIYDKIYFNPKKHFEKIDIIPFNLTINNILNVLYCKNSKIYDLDETSNVFIYMCGHGGEGYIKLCNREYLLYPDIKKAIMYLCKRVGKVLFINDTCQAESIFDGLYQIDNLYLVASSERNEPSISTQNCSNIGPSLIDNFPYKFLEIIDNCIRLDLNVFFDLFDFESVMSHVIHSNDSRFKVKDFFVQRREKELFLFMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH1</accession>
    <name>A0A4Q9LYH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0621p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000621">
        <property type="protein sequence ID" value="TBU12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0621p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9370" checksum="1F2B26B03EED3033" modified="2019-07-31" version="1">MGMTSAEESMDSIVAEDNMGRISAGESMDSVVVEDSMGMISVEESMDSVNFMEAVIYAEHGTANIMEIIQKFTLFFERCDALDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP3</accession>
    <name>A0A4Q9LYP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0286p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000286">
        <property type="protein sequence ID" value="TBU17599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0286p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="38447" checksum="B9ADDC55A81EEBDA" modified="2019-07-31" version="1">MNQHILSKYGSKNKFIPFCFLLVFIINQITSEQIEFRFINKEVSSLYSEEWFDDYNLKFEKENIECSEKRDSNEYKTVKFDYDNKNGYKSGMIDTYLNPEKKYNKESILLPIYFNIEYFDFFNSLLSYKKISEKFNEDFMFRFCFITDYFLFEFEDVFFEVIFRELFNNCSLFFKNTVEFDYCFYTWLFGSFPNRLYKFGFYSKRSDNNFFDIIPQLENHKNIKELILENITVDAFCLFIILKNNNVTFIKLKNCKINSYEILQKKQIKFITSNLEELYFECFSYDLVILNIFLDLSFLRSATLLNYTGKQIYDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT3</accession>
    <name>A0A4Q9LYT3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0271p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000271">
        <property type="protein sequence ID" value="TBU17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0271p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020524633" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="22761" checksum="2E1B6CE9EB7F081E" modified="2019-07-31" version="1" fragment="single">MKGIVFIIGLLSLMISYTNCISNINVSWITMHLMGRIVYGAMKKGSELTKEWEEDLKNSVNEAFNRMCIGSIPVNPSRQPKTKNFRFITTNSMQDLFDFYFIVEPGFRLVKESIFDTIDFLNADKFIEDVNKQTKEYLLKEKIKRDEFVDKVISKFSSLVMEKLKCLLENKFSKAKKCDDNNSMILNDGYKVLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ22</accession>
    <name>A0A4Q9LZ22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0547p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000547">
        <property type="protein sequence ID" value="TBU13050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0547p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14704" checksum="C564F7F7FD0E6B54" modified="2019-07-31" version="1" fragment="single">YEKDCFKKFFLNLRDIDLIIKYTEICSSTEKNASLEATDNDKSFSTKLKHISKNLDNKEKYKGKDSEYFSGLFICEAIMARICSRKIYKAIHLQNSFYTYVRKRNLKELPMDKISGAQQNFKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB7</accession>
    <name>A0A4Q9LZB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit Sec6 of exocyst complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0227p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000227">
        <property type="protein sequence ID" value="TBU18866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0227p0050"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU18866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="83496" checksum="E031B7F68458C166" modified="2019-07-31" version="1">MHETLENVNDTLKYPSDLEDKLPSILSAYEKHVNEQEEYLKTKIRNSRDRINNSINLQQKIKSDIEIYKSNFKKLDQIYQSFPKVVNNYENIKIIAIAHQNFHKSYEMHKKLVNISNATENILKMIKNEENIENIHEEVFELEKFKYEIHFFSKNITRDEFLKLNEIINEIDRVLLEFENMFLLKTNNLINQLEINKEYLNQISKIVKKEEERDEITIKVQKGKHSHDAILHEIYLLNKIYFDREIKDIKNKTIKAIKYSINDKFPKLQNKDFNIQELNFIIEDMKFISETVNDKDLFIDLRFIYEEYHLQLKNFLDLNKNNLDASQILFLLEFINNYNENIEKNLNMQPETLGESLLGDSESELINKYLQIASEKLVSWISNITVIEVEKFNLRTSQPTVDENDKYISTGFINLLQIIKQQMEPITFNKHIFLQITSIVVENCHYFKNEIIKAMKKDFKPSVTLKSVPGYEEYVIMIGNSGLKLTQYINSLPLCQKPEVRELGNIFLEILKSSNTLLSEFIITTCGPILDKVFTDSWYEQDITKKLIITLEDFLGDYKITMADYSFITFVFEICNSLVFCYVKQITRKRAKILEDCSDKLKSDEKRLIQTFCKFADPQEVKNSFMPFDKIIPLLTTKNDDLFVVELKSLILVYPDIKKEFIKSIIKKRTDLNDSDKKNLIERLKESFGEEPKHNKKTLFSRLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI0</accession>
    <name>A0A4Q9LZI0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0353p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000353">
        <property type="protein sequence ID" value="TBU13717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0353p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25826" checksum="0CF8CAF577EBB42A" modified="2019-07-31" version="1">MYLNIKNNNLLLCISDLPSNFPDTLLEEILKLFGKYQHYKRPADVNGSSCNFCFVLYFNIDSVIKCIKIIETVDIGGLKLKAHHDDLNNILNIISNISSNNTILDENTNIYRKAADIDTQDLKRINKRISEIFSVYFRIIKRDKTIRNFIEENCIKNEKSISIKKSNLVNLENEWLKEEQEIRNKCIWTIQNQPTKKIKEIEEENYNYYLTYDDDNTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU8</accession>
    <name>A0A4Q9LZU8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative subunit 2 of origin recognition complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0182p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0040"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="31276" checksum="C658FEF009C65B85" modified="2019-07-31" version="1">MSNKLENFHLKCKEEYNLIIEDFNILFYGYGCKKKILSKIFTNALIFNTKIMNQSEIFNLIKSTVKTKYKIYLPENHKNFIKILDAKLYEKNIKIVLIFLNFDFFRLSVFNGFRNIKIIGTLDNIDIDFDLEDLDEYNFILRDLTTYEPYTEEIIDMKFHTETKRLENAICVYNNVSKRSKNIFKLILEAKKEKNDLNMKDLYEKSTKKYFIKDINIFNSYLVDFFDHEIFKNNENNMLTVNLNNIEIDKMLEHINTLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ4</accession>
    <name>A0A4Q9LZZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0175p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000175">
        <property type="protein sequence ID" value="TBU19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0175p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="539" mass="64542" checksum="90A59A6CB2C4FF4E" modified="2019-07-31" version="1">MFCNTSRKKNKNPPNTSRQRNKTVKESKKKNKAEYVVLQTDIVIYNDEKSFMYTKISDYNKNLELLEEYFLRILNDYLTEDKMETDYKPKLIKIVAECDDIADSERRYEELFKRIVDFTKKAIMGTEKKFLHKYKDDETRKEFFKQLFEVTVEKNTNHLSPYYRDKEFSSISLAKMNTTKIDPTETLQKAIEKPDSLEFYNYFSNLLLQSFSELMLNLIYNFRNFGDLYEFLINNDTKNLELKRSSLEKGNYIFEKSQTHTENYYKLFFRDLDYKVISKSKYYKGSKHFQENSEDDGIYHQKIIQTPLDKFFNFSDEDMENFSINIDDSKNLITSAESKTQKAGNCSPKDKDIRQKFTDFLNKLKILNIEKSDSPPNIYYILDLKGIYYEMMTNITNELYNELAKKHVESAKFSFQEQKLSGFLEKIDIFLKIYYKDFNLIVIPSYEFIFESNRGNEFRNKFYDQFINNKEADEIKSNLMLVNSNYFEMIDAKILKFFDEFFKTKPSCSEMRRWKPPKKMIININKDSGLEVECKVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M040</accession>
    <name>A0A4Q9M040_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0433p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000433">
        <property type="protein sequence ID" value="TBU13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0433p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="772" mass="92611" checksum="7911CC0D474E317E" modified="2019-07-31" version="1">MKVKLQNYFLMIAPRFHAVYLFALIFWVEALKLEKQIILHFYTEIHEVEANTERHNEFETSFSKLVKRKYNCYRHKECMECTKLVIRDCDMSPLTFKLEGEEIADRIIFINTNILTYNEFRYFLKSLQAFNDCKENFRIDDCVLIIHILDVFKFKKDKIFHQFIRIVLVSTIYNNRCYCTNSKVLKSITPSSSICKSILYEFCSIYFFDVNSIFGKTSPQLIKKIIKDNFDKDFCSKKQFVQITSKFLVEIDRQMQYNREFKIGLRIFFLLFRPLRMVSYCGENNNHILNSFLFKPYTSTSELCFWAWKDMKLLKRTFQNLAFKNVKTLFFFYCQLTSFKENYFKNFTCLRDIYLFHSYGEYKVFSDKSYTFIKNLVSLFYMEIIEDQKLTSRFLKITNNNKSINIAPINMHSIDSTNKIFISQEEFDSENYQIYLSDTITISFSNIEFKVNILDRSKIRKIEMHIYNIYVDRIYFESLYISKNLKGFQIHRAKLSSKFLSEVLLLSNLETIVVTDSTITFPKHTTNYHKHLLMNELSIIGCVLENQDRIFEFINSMPKLKNLTLLSNIDTYFFIKIFENNMIKLSLLEKFHFSEEGTCDSGFLDFLNNDSIIDLNVGFRSKEGSLSELFGNEKMLNIEKLQLEYFKIGFKDRKSIVNYKKMHYLHIFECDFYQISFSELFDKNEECAIEILTLINITIRKCDIIFLSRLRKLRSLSIQTKYRFFDYVDLFRFVRFYSSKLNIEIGFHQLLWSEKHKFKEIFGNNQHEIYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G4</accession>
    <name>A0A4Q9M0G4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0138p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000138">
        <property type="protein sequence ID" value="TBU20065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0138p0020"/>
    <dbReference type="OrthoDB" id="2192310at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="395" mass="47700" checksum="F233E10FB29D9130" modified="2019-07-31" version="1">MIRHGQEKGSLKEDEFLLKEYFKLKDIEMDDLESVKKIVQIIPDYYPAWNILKGYLKLNFGDWPDQLRLSQKAIEFNPKSYQAWHHRRCVFEVIQYHLYKKHSNFDTDDEIPFETSFDIELHPNIELVTQKTPRKQVKFTNLIIPILAHTFYTDEKGLYIKNYGIIYEQELELTAAFLGVDERNFHCWNFRRFLVENDDLPFKMYNKDFSNYSCIHHFYNKKYTDNEIISKIFTCPYDEGLWQYYWVMEETQMFKNGVYMKIFDDKIEIKFKDKYKGTLYIKIGDKKIKVDKKVSYKNITVISKIKKEKKYILKDSNKKVLASGFLKRQDYFYDFVEELLEIEEDCNFALLTLLERTEDQAKRNKLIEKLVLADPKRKNYYKSLKYGYIISGMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P2</accession>
    <name>A0A4Q9M0P2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0117p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000117">
        <property type="protein sequence ID" value="TBU20189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0117p0060"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="277" mass="32961" checksum="9F29288A8916604A" modified="2019-07-31" version="1">MNNLLNILITEIKESHEVPLVIEWCEEFIRNYYKNNEYFESMLVFYKKNQVKCSEKHEILNICVNLFYFGYDITNNICYNKYTDLDERSIHVVGSMVCWAAIGNILRKNFNDVLYLQLTEIFDDAGLYLNLPNNRNICLNFNMSKLRLNFYTKVYLPLKIKDALNCENNGNNYNKYENIFCFSYLNKEFRLKNLKKEELFDNFSEYLKFFSEDIDLGIIMDKIISGLYIRELELPEIKIHLKTWKNRPDIFILATKTLVDVGITSQDSLQIIKIEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V0</accession>
    <name>A0A4Q9M0V0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0097p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0070"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="20145" checksum="61CFC66514B8BE35" modified="2019-07-31" version="1" fragment="single">MKNCKITDIKIYGNMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPEIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M145</accession>
    <name>A0A4Q9M145_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0076p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M145"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="653" mass="76999" checksum="7ABCAE3866BB1287" modified="2019-07-31" version="1">MVLPTSNIYLCFKKDEMSTSENMNDFFQLDLSGFALSREYFNSTTYISRYHSSEFSDIGYINKNILNLVSTFLKIEKSIELSENKRFINKGDIKYAKWKIFYGFLQCKHGFNEEDLIDIYLNFGFISNQKINQISQNLKKYIIKVFLKIYNAEEIYRRLFSQDISYDDTLQKHRKIFQESITESLYISCSDPISKILRIVGNTFLENISGVFFRILKIRKVIIHTYILQNFTEISFFEFISHSIEEITAINAGYNLHQLTLLENRDQFPNLKKNIFFVFASNMEYSFKNLYFIQAFVGFDRWKIYSQLQIKASNMKYSGYLSPKIPNFARNFQNGGKHLHSYFLEFQTDIISLKICCLEKYVLADHIVNFLENSFKNIEISIDFVNVKEENIAIFIPKSLKIVSIEIHRSIVSEKILDCCLQFPYLKTLKLKYNCLQFNGGLLKNIRETAITYIDLTDNKFEHNGMLLNILDILSSNTNILINFKIDTAFIEEIENHIFKNYFMKIFNNFDKNFNGEICLRSIDGELRELLIFSTNLQKLLIENLKNFKSLVVKNHSISFFPSVLDFSNIKKEIIPENIVCIDFYINRIDFECLLSLKNIKQITFDDCVFSDDMLYFTASDFEESKIRVQIISDYDSEVNDLSEHLQNYFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M156</accession>
    <name>A0A4Q9M156_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF572 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0323p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M156"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M156"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0030"/>
    <dbReference type="OrthoDB" id="2190313at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22767" checksum="EC6EDFBB34D4D45B" modified="2019-07-31" version="1">MQKKREKRIGTKYFEKKYSGIRFALPFTIGCITCKEYISKGYKFNAVKEKVVGETYLGVEIYRFHIKCTNCRCEMTLKTDPKNGEYIVEFGCLKVNEIFEKTKKNLEFEKNYKEKEEREDPTKILKNQIKEAFQERSGIYQNDDITRAIKISQKTNIDELIEFSKNKEKENELKKEAFKNKMIDFLKNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M173</accession>
    <name>A0A4Q9M173_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0075p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000075">
        <property type="protein sequence ID" value="TBU20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M173"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0075p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="344" mass="41021" checksum="D656E0BE1F4AA20F" modified="2019-07-31" version="1">MMNRINKYIYFSILYFLLQFLTIQTEIIVRFHLQNDSIKKVEESDRKSIGKKSFLNFPSKFQTVKKENVVKNVKIVKIPISDFILLNCKEIEFHKKNDGLEIDIDLSKIYYSEFTAFHLYLKSCYFPNNLISFKEFVRFLVVLDELKVDFDAFIKLIDTILFNLYNLFESRKFYLKDSDITDSMAHYNISFSILNFIFGRFIEKYFDCNDFYDFFYNRNDINQENKELGKYVKLFLEINDKYVLISESFIKKIIKESLVKSAGFFLLQTIIALSDTNTLIIYEANDTNVENLTNTISLFRKKPSKIIFQKFLFNPRKKLLYLKISHLFTIVASVIFVFMTLTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F7</accession>
    <name>A0A4Q9M1F7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ADP-ribosylation factor GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0055p0070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1F7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0070"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="373" mass="41873" checksum="37DCE43DF1A12F91" modified="2019-07-31" version="1" fragment="single">NTLLFISTYINTLLFISTFTNTPLIYLSITNTLLFNSILLLTPLISISTINNTLLFISTLNNALISIFSYTNTLLSISTYINTPLENPTYQENNKKKMKNYNKEIKELCTIEDNKRCIDCNTYYPQWCSVTYGIFMCIECASIHRSLGVTTSVVKSVNMDTWTEENYFKMKIGGNKSFSEFLNKKSLSKIETQKKYKNCDVIKYGETLQSKVNSMIGNSSGSVGKVSGSGCTSNYTNRSNTTNTNNTNSNTNSTYANTIYSSASSVTFNETRSVQDKISSTFYKLGEYVSTGALIIKDKTVQLGGAINQKILEPTLSSIKGQSGYISNAWTNKKVEIKPVKTKKEKDVTNDIDYSKSKKEKDVTNDIDYSKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J9</accession>
    <name>A0A4Q9M1J9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0047p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1J9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0030"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22165" checksum="5AA48D312047EAC1" modified="2019-07-31" version="1">MTDYNVLISTVKNENSENTILLCKELQKIIPNSIYTQDILTTPIKIQILEHNKLPYTIKIAYKDIKYDFKIIEYKSTKALNNQNQISGYNPQLVVNNFNTDIGTNILNILMELFPYDFSARNRQVVNFTNKNDYIFFRMYRYIFKEDSSIDLAEIGPRLILKLSKIIDNENTFNIKYSSKKYSSETAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S8</accession>
    <name>A0A4Q9M1S8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0260p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000260">
        <property type="protein sequence ID" value="TBU17979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0260p0030"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="357" mass="42862" checksum="6A908D2FF5BA32C1" modified="2019-07-31" version="1" fragment="single">MERLTKSVSFIERNQGVKKIVNTLITKDDITDVFLQNHDPFSLSEIGKTCILQWNPLLLKHESFLNLTSKVHFNEMLQIKPFEADVKSKIILIFKYLIYIMRNTFNHELYIIDPSHANYLYSYDLDVSYHSFLFHNEFYNDTRYLYNDRTVAYFKSLDLNFYAKKKFEIFPDFDSNKLNLEYSYEEANLMKFKDMSRDYIKDEFINNNILDIDKFHYSLEFNLIYSEILKHEYYINSEAKKLLAIEIMANLLLAKTHFCYKTEVFLYFMNMLFSLSDLDEYLVNSLSMFADNILLLARYHSEPEECFSCKKIIKDLHDRLGSTDFAILYPTNMRIKNKLRIFCNYLYKDLCKKKEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X9</accession>
    <name>A0A4Q9M1X9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0255p0050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000255">
        <property type="protein sequence ID" value="TBU18015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1X9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0255p0050"/>
    <dbReference type="OrthoDB" id="2189922at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27623" checksum="2CE0B8562EE3C84A" modified="2019-07-31" version="1">MNRTQDFLSLIDLEKNIEIKKNKKEKFYDSFLKDINILQNKIKKSGRYEEILILDEAYTSLSNKISGLFQVIEIDTSLNEGLHFEGIKKILNNKLQSVQMLLQEKKSTFLSTTITDLEPEKPIIYKRIEDTSQLFLMEEENKKIMESLTTIDYSLKKTRKRIMDIQSIQDIIGLHLYAQDERIDCIIDTTSDTKKNVIGSKSFLDKNKAMGKAIRRIVFIILLCLSFVLLFLHFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z1</accession>
    <name>A0A4Q9M1Z1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0158p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000158">
        <property type="protein sequence ID" value="TBU19988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0158p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="23058" checksum="AE6EBEF2E38F2E9D" modified="2019-07-31" version="1">MFLQLLDCLEKCEEIQLEKQQSQKWRIQIKLILHHKRLLYVFCYIQIETYSKHFNYPRKTVICLEAKFMKIIGHEYNRQHTEILKYLTQIMSHFVLEILNMGHMKIRDDTRIKTDIKYGNTLRILAKYHKRYFKTPKILMNEDSRNISFDRKRELEVLMGVIKRAEIHEEPMPPLKAASNYEDDVKEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M240</accession>
    <name>A0A4Q9M240_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0109p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000109">
        <property type="protein sequence ID" value="TBU20227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M240"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0109p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="671" mass="81945" checksum="4E1936BBBC6FA132" modified="2019-07-31" version="1">MEFYEKYKRSILFLSIGLGILSLGTIGYFCFRKNEKHSEKNVDIKVNKHYSKKPSTESSLHVFKDEKCVRRNKNIADKEPDHILKAEKKGTSSNISINQPKRKKENHTEEPKRNAKHVSPIKRQTGEFNRNINGKTKNEFCENQKKTIKTPTYITEENSYIENSNQNEQKQIPIRKFIKNQINDRLSRGAQNQKLTQNEQPKKDTQNKRIDIKRQIATQEHKNNQRKYSHENQKKTQELQNSRGQENQEQRLGLKETIVLSKQEKLDQEKQSKINRQNLQKIQRQSLQKKLMESLKLKFQQKRRSQKQITEEKQLKQQEKQESTEQMYETKIEQKINNLPIQQEKKQDCLKIVTQKRKNEFKNKLEQAKYDASQKPVHTLVKNVVREQDQEMMKEHQIQQEMETEQKEFQRKLDALKNQKKKYDELEKHKAEIDQKEFQRRIEELERQEKKDKAREKQEEKRNQKEFQRRNEELIRQEKEDKTREKQSEKRNQKEFLEKIEELKRQEKEDKAREKQAEKRNQKEFLEKIEELKRHEKEGKTREKQKEKRDKNEFLKKIEELERQEKDGKARDDQKEKRDQKEFLEKIEELERQEHLEKARIKRKEKRDQKEFENKLEELERQLLEEEERMKLHDEMEEEEFEAILEEIEQEQNELRSESISLWQRFKNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M245</accession>
    <name>A0A4Q9M245_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0139p0020</name>
        <name evidence="2" type="ORF">CWI38_0210p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000139">
        <property type="protein sequence ID" value="TBU04406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M245"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0139p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0040"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="164" mass="18127" checksum="5780904E992E789E" modified="2019-07-31" version="1">MAVLLEEEEQAYESVCASDVKSGNIIMLDSANKIEYYKVSDISKVKTGKHGAAKVILEGQILGSGKNITKQFNGGIKLNKVELKKKSYVLVDVDEDNDSLCVQANTTGGNEDIEYLQLNRIQESDLSKIKEYFLANEGEVVFTAVTAKDYLAIEDLKISKVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M306</accession>
    <name>A0A4Q9M306_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0049p0060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M306"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M306"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0060"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="529" mass="58298" checksum="13D0A1F5E92F3C3D" modified="2019-07-31" version="1">MNVHECKDTREGKPHILQNINTITNLASHLKTTLGPFGMDKLINDLLTNDGATILKNIVRDNEPICKILLSAVNSLDKEVGDGTTSTTLLSSQILSLLKPLVLENYPISTILECLSQARNDILKHLDSLKQKVDSSLLYKIAETSLTSKILKYHKKHFGEIVVKAMSRPNIDSVYADSSINLDSDFYKQSVVIPNISIKKVTGGSLQDSCLVNGVAFAKTFTYAGYEQQPKKIKNPNILCLNVELELKPEKDNCEFKIDSVSSYKDMLEGEYKVFLNRLDTIRQTGANVVLSTLSIGDYATQYFARHSIFCCGRVSEEDVKRVVECCGGEIISSIESLRNKNNETQIQRFIGKCEYFEEKQVGKSRYNFFEGCEFAATLLLRGPTSEMLDEVERSVMDAIGVVKAGLTSKGIVWGGGSCEMSISRFLRDQGIKRGDSCIFVYMVLAQAFEIIPFTLALNSGNDGVEVLGLLRGEHNEGKHSAGVGGDMSLLGVVEPVELKEGIVRCAFSVVETVLRIDGTVVAKGKEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M337</accession>
    <name>A0A4Q9M337_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit 6 of transcription initiation factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0064p0060</name>
        <name evidence="8" type="ORF">CWI38_0045p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000064">
        <property type="protein sequence ID" value="TBU04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000045">
        <property type="protein sequence ID" value="TBU20607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M337"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M337"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0064p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0045p0010"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="363" mass="42131" checksum="3C016A997442DE38" modified="2019-07-31" version="1">MLFSKETLKAFAQSKGITNVDDDALRILAQDLEYRIKEVCQEAGKFMLCSRRTKLSIDDVNYALQSRNVEPLYGYDPQDSLVFKNIPSNIYYVPDEELDLEEFLNRPLPKIPLPTSLHSHWLAIEGVQPQIPQNPLPLEKPIIKKDLLMSYQEEAELKSQNKHVLSKELQLYFDKIVLFMQGSDNEREIALECMEKESGIQQLIPYFIQNFSEFIIKNIFNSKNLTTIIKMYESLLKNQFIFIDPYLHQILPAILTCVIGKSIENDTIRISASNVVKYVYNRFSSSYNTLAPRVLNTLTRTWLDKLKNENSQYGALYCLSILSDNILETVILKNSEKYKNEINNRKVTDFLNELVEKYKGNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M354</accession>
    <name>A0A4Q9M354_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0043p0070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M354"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M354"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0070"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="78"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="326"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU20627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="444" mass="48342" checksum="FB93A1926EECBEB0" modified="2019-07-31" version="1">MTVCREKKDSDVVIVDYGRTPVCKAKRGMFREYGNDYLLFFVLKNIVNRNFKVGDKIGESGIYGGGVDMKYKQRDEIEGDKVCVEEIGDIIFGNVLAPAGGSMTLRMACIHAGIPYTTPFLTLNRQCGSGLEALEVLSGKLKNNRIKIGICGGFEFMTKDSLSVKYDVSTELYLDDRVKKCLLPMGETAENICKKHNYTRKDCDIIGYLSHKKALKAAKDLRYSEQIIPIPVSDKGKVYKLDSENISDDSLSKINTSGIDNINEENFVTEDEGMRVCDVEGLGKLKPAFLVDGVCTAGNSSQLSDGACGMLVTTREFAREKNLSIKSIFVDYCCVGVDPSLMGIGLVSAVKKLLENNKLGIEDISLWEINEAFGVVLAYCIQELGIKIEKVNKWGGSIAIGHPVGSSGARLVGNLICGLESGCYGVVTLCCGGGMGVAALFYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3E4</accession>
    <name>A0A4Q9M3E4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0144p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3E4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="29140" checksum="02589352955864D5" modified="2019-07-31" version="1">MILHNEIPTRCCGMSLTLNNTSKLKSFLFKNITISGIPFYTFLFTLFCISFIIPVFKQKYLMKIKKYKKRKEIIYQIVLYLYIFTIKSFIFLVSWMLMMVSMTANVKIIFFILVGHVFGSIWCVRNRKYRNGKIRNNFYKDIESSTCYINYKCSVEIIPYVQTWAYIVTKYHKYHLKRQQILINSVNVRYRESCDVGDPTPPLKQAKPQEDDVKHFKTKDNRPLISKRGTMSEEPTININEESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3P1</accession>
    <name>A0A4Q9M3P1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="9">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0127p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3P1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3P1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0040"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="22529" checksum="9EE2249E588AA734" modified="2019-07-31" version="1">MPTFLNMAVCCAMNQNRSMEAHGLLQKKGFKVSSYGTSNNIKLPGMSITQPNIYSFNTTYREIYNDLREKNENFYRNTGLLHLLQRNISLKEKPESFFEVERAFDLVITCEERCFVFIFEYYGRKEYLNDYSDGVFYLVNFDIKDTPSDAILGANEILQFVKIIEDCNLDIDTAIEKFCEIKKCTLLYTVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4B6</accession>
    <name>A0A4Q9M4B6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0065p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4B6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0030"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="35048" checksum="378D954C8A76C61B" modified="2019-07-31" version="1">MVKERKLFCYIQDRNVFLGAEGVCQHCNTSRKIVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRQNKITLIEVGITSQDSLQIVETEKLKKYDLLANELGLIYKCSIEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLNVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILSLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4N3</accession>
    <name>A0A4Q9M4N3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0031p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4N3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="264" mass="31652" checksum="52404DC870024048" modified="2019-07-31" version="1">MKNYKLSKTDVCLEVLNKDTHVCTKEQSRRDKYIFFLVLFFHQICFAGIFILFLSYVYKYDIAVELCIKYFIYITIINSYFYMKNRKEEIVSNTIVRYLFSYGVNLLIIYLDYYMSFLINIGKNLNPISKFTYEQSSLFLMFISFILFCNAYYYSKGIEKFINIKKCSMALFCLLYTLESIFLLTLKFIKFLGIIDYSNEPLLVPCLAIILSQVFLFFCSRINTRKMKLIILPMMLNALYFWNFFKDVFVRLSILMISYKNILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Y4</accession>
    <name>A0A4Q9M4Y4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0041p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000041">
        <property type="protein sequence ID" value="TBU20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Y4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0041p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020766836" evidence="1">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="25959" checksum="039ACFAE48E853AA" modified="2019-07-31" version="1" fragment="single">MEIRNIVMKLKFLVILQTMWCSNIAESNNLILSNDFVANPERNDEVDLEENRKSIKIKNEKIYQKFKSELLKKDTTSVSKILHTSLNKSNKNFSQNPLSNKKGINNHYSYFERTDSRILNPKTRSDVSLKSNNSNLCSTSIDESDTETSNISSIYSSSDLSYDADIETSSDDFYPSLFKERHDDNNSANNSINCATENMNSALKKENISVDIVSETEAGVKSNLIEAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5F7</accession>
    <name>A0A4Q9M5F7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0022p0040</name>
        <name evidence="3" type="ORF">CWI38_0004p0090</name>
        <name evidence="2" type="ORF">CWI38_0006p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000022">
        <property type="protein sequence ID" value="TBU05345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU21002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5F7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0022p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0040"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23275" checksum="4DE64D22F968B59A" modified="2019-07-31" version="1">MIINIHEEAAKKKEIWIKVQNYIVVIFRDKLILEKISLILHKSKTKLSVILSAIYYFKKVRRRYALYLKRLDNLVTCNVTKYLVGKKRQVALQATENDFNLFVISIIIACKHLLDTVYTNYCWAEVSGIPISNLNAYERTILDILDYRTHIPNQSFYNIVDEFEKITGNVTIDRTSPTKKTSTLKCVLSCITTKLTCINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M641</accession>
    <name>A0A4Q9M641_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0001p0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M641"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M641"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0170"/>
    <dbReference type="OrthoDB" id="2190904at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="44824" checksum="E184C3071299F30D" modified="2019-07-31" version="1">MEISEGINEKILQRDGKTISKLFKLNCMIATRNLSVTNFSKVHSPFSLLLFHQYDLIKSPSFEKSLNIFLQFTSSIKEEDEWINPIFKKIAFNTLICCNETQNIEKYAVQLTNVFKQIYFKKENITTSEVNSNFSSQKNIIYEQKSLVFYISAMIFNLYFKINNYRLADNLLLILENNNNKNMKSDLQDILLFNYYKGMLKLYRNNISQARDYINYVFKNCSKKMRNRIFVPFFIVNFMTGKIVKEKSLEIYKCEYLKPLYKKLVNCRFDFSDELRNLENIFLKYNVLKISEYFLDYIILRMNLIKVFKLFCVDNKLEIFYVIEICKMNGIKLDGSDITTWILNIIDKEIVKGYLSISKGVIVFSKVNPFPKLDNLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW95</accession>
    <name>A0A4V2JW95_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2461p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002461">
        <property type="protein sequence ID" value="TBU07052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2461p0010"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="163" mass="18986" checksum="293690C3E1328A00" modified="2019-07-31" version="1" fragment="single">RKSSIISPDMIVSRKNSELKAIQIPHRENNIIKNTKPEEAISAIPKPKKSKLIEMFNWIQKYDPIYKANSMAKKYLAFLIKNIDVYTNRRKRSKQENLSSEDKKNNHVESEHHRRDAINLGLYALSEIIPGPVSKSKKSVILNAIHYIMKSRYENSYFSKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX34</accession>
    <name>A0A4V2JX34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1885p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001885">
        <property type="protein sequence ID" value="TBU10272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1885p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23348" checksum="86070FA52E3EA8E2" modified="2019-07-31" version="1" fragment="single">IRSHSVQEIIDNEIKIDVKIRNNRPDIFILDKRKNKITLIEVRITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSQLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGEPTNNINEESDLEEETIVVKEVEENIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD2</accession>
    <name>A0A4V2JXD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1258p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001258">
        <property type="protein sequence ID" value="TBU11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1258p0010"/>
    <dbReference type="OrthoDB" id="2233964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="376"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="498" mass="56979" checksum="AB1CF0967BB4D506" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNEKIKAVNNLENSAGVILMCDVDVAMLSERLPPPPTLHDTTHQPPSSSCQTINGMKNFNTDAILEENLLMVLHSILDSVTVQCKRGLRECPEMADHQLWDIDAFKKFAQNEAEREIRQEENEEQRRIATLHKPERQIFSKIKEISEKEIGTVVVRTRKLPSELVDSKVLNIINRIIGEYADSYVPMTITAVAQIIEAAQKARKQENLSTSETKSLKKIMREFNLNLSSVTDLSEVLQLRNENRMFELFRDRFYLELSERLKSEHVVSRDEIVSFGSTMCNKNDDMVTYNDYLIPFVSDNHPTTFPSLDEFVNIINCLPNGKLLELMKLTTLHKYLYDIVKVICLEGTPQADWFYCGLTYLIPKGSPQRGSDYRPITCMSNLYKLTTKCVTKVVQLEVERRGLLAESQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE9</accession>
    <name>A0A4V2JXE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1160p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001160">
        <property type="protein sequence ID" value="TBU11522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1160p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="632" mass="74447" checksum="98E1ACDB4BEA7B26" modified="2019-07-31" version="1">MRSDRSDVDFQYKFLNDCSILYYEVTHVFMYEKDNFISFEVLNHILALQKSEKLNGIIECNFNLYYFLNTTKEITEIPDEINHTNIKTILLGLKCLKAVNCKNITKYIHALLVKILLNHKKNALMKNYMYLGGLFDLNFWSNIDEYIKKSFISGFLEIYMLKYIFYDGNLIVLENVKSDYYTSIFNDHIPYKNILINSCKVFLCLEKMLLNTLIFNFFQILLNVMNLKSLILDGSIEYKIPNIKFKFHIFYLETFKSIVFFNFMKSSSSLFLENLSVLIRNDIEFLQLELLKVSRNVLRLLLDQKNPIGLVLKNVSIPHSTVILNRNINFCEKLRYAQFQNVGINPFWWNNLFFKSNFQTLILSFNSISSEESFIREFSKSRGTVRAILHLEISFYCTEIPKEFFDSLLNLNHLRTLKLQTYKTNEQTEIYLINAIKNMNRLENIDISQNFFSTKSYNILFMKDGIETLYLKNDEFEINILEIAFTGNYKLLKQIGFSNMTIGITGLIEIFKLENLEMLSFECCIFESIDNFCFSYSKSQYLKCLHLHDLDLNTNNFVYVLIKLDFLEILEISSCKIQPGLLTGLGLMCDKSLSILSFKFGFLNSNDLNRIKNIKVLEDLNLMECRFFQCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI2</accession>
    <name>A0A4V2JXI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1020p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001020">
        <property type="protein sequence ID" value="TBU11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1020p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="492" mass="58434" checksum="952F8B05F6C76453" modified="2019-07-31" version="1">MESANKMINLLNERIYRLEYPISANSDENKSFSITITNNFQDTIEDISLAIPLVKILFQTHIDRLKSLSKNCLILSIEKQIKFIDCLGDENLRNIKIIYRSLFLIFIDIFVARFIAFWNVQTFLKENEFTVYTELLLNEEFSNPRILERLDAIKTREINEKELVTHEEKIKIILDSIHDEDFLSFLCDEVTVAFKGGFGALNKIFPELSIYDLNKNKEFWSAVIENNQFVKAIKKIYSLNNWKCPSYYDSAISQTQIEYKKQYYDSLVFMISNFGLVDKTPGSYQPKTFSWIIDFDDIHTPLMIIDDLMCVFPKRYHECFRNSINFLFLKLSSRSLNLTFKLNIEEWLTVFIKQICLKLERVMFFHVLKQNFSEIEKERQTQLNETFKEITNLTPFCDEIKSFFVTLKNEIRSSTYVCFYLHSVCDSVFRFIFTKFINENGFDHEILQEDGTDAIPIMQKNILLFFSYFFKSALTEYFKTEGFIKKKRIIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN0</accession>
    <name>A0A4V2JXN0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0755p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000755">
        <property type="protein sequence ID" value="TBU12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0755p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19488" checksum="06B7316A58CDD427" modified="2019-07-31" version="1" fragment="single">MIKVILILWPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKFRKYDLLANELGLIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR0</accession>
    <name>A0A4V2JXR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0638p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000638">
        <property type="protein sequence ID" value="TBU12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0638p0020"/>
    <dbReference type="OrthoDB" id="10027416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="752" mass="89618" checksum="4DF42B8C0739F508" modified="2019-07-31" version="1">MNFIPCLIFVRILASEIKIYNSNKIDNKTDNKTDMKVENCNKKNYISIFACNDTNSTCKDSDALIFYYPNDFFIKLNKLEKTDDIFIKEYNLDTIVYVLHQLNSKDYINGKSNAKNFLILIDLLILFEYESNKSIKILMYSQIINLRLIDYIYLKNYRLFYCSDSNIQNIFVIIFKQFLKYHFFTKRDVQELFGRYFINKNKKNIIEFDKMLKNEIFFCLTKSILQKLYKIIDGDTKKQDFIKYILSKIEIKRLKIINIKSLNNLLHMNRISQLFEHSSIKELEFDSFVICLTFLIIFSRIDTFKKIETLIFLNTTINSSHLYELKSYTNLKKLVFINSLKKDSTYECFPLLNESLPNLKYLKIYEFNMKSVFEQNIIYFEKLGNLKIEFMTEKTDPLFFDSNFINIFSDKLTHFECRFDFIRLSEIFVTLNHFSSLKTIILHGYHYTYLKKSNDFDISNLSFKNNLEILKIYIFTINEQELYSILNFAHLKTLKFKYCEFDIASEYSPNQSNCFSKIQNFTLNFTKFPFILFTYVTKSEFLDKIDLSYSLNSISFSIYSLEFTNKENITKINLSGKYFRILTRNIFIGFLKLKNLNLSNTTRNGGNLIYILNENICKSLEILKYDKNTIRIEDIQSIENIDRLKYLSLSGCHFINNCCFRADSIPIYTTIKYIDCSSSDLSNKFMKSLMKFKNLRILKILFIKIKYKKFKFLQNSNSNCKILINKGSSYKKKTLQQIEELFSEENLIFMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK5</accession>
    <name>A0A4V6MVK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1668p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001668">
        <property type="protein sequence ID" value="TBU10582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1668p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="10647" checksum="231F3DFEB515FF71" modified="2019-07-31" version="1">MIDKYFFTAFIEESLQKYTIKPLKDKKKYDIKLFCSSFLPKILSTKNISLKTNDKGTYIIITDVLPLYLEYKNNWSLIHSKMLKVSFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZM5</accession>
    <name>A0A4Q9KZM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0986p0020</name>
        <name evidence="5" type="ORF">CWI38_1217p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000986">
        <property type="protein sequence ID" value="TBU00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001217">
        <property type="protein sequence ID" value="TBU11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZM5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KZM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0986p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1217p0020"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="240" mass="26653" checksum="87195845C65F5762" modified="2019-07-31" version="1">MAIGDAKTNTFTEEGRILQVEYAIKNVSQAGTIVGLNCNDGVLLLGIKKGAVQSFKEKIYKLSEGIYCCVCGIFPDALQIVQYARVNAQNFLEEFGTSMPVSTLARKVGELKQGFTQSGGMRPFGVSFLYAGIKDNQYLLYSTDPSGTCNAWKGKAYGEFEDAINNGFKNDLSDDNKTFKEGLKSLIQIISKSRECNEESAPLFEVLHLSKDGCKFLTNEEIINVFKEIEKDEKMKNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L685</accession>
    <name>A0A4Q9L685_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0549p0020</name>
        <name evidence="12" type="ORF">CWI38_0467p0010</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000549">
        <property type="protein sequence ID" value="TBU02130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000467">
        <property type="protein sequence ID" value="TBU13325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L685"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L685"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0549p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0467p0010"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="816" mass="94496" checksum="DD86191DD7C60553" modified="2019-07-31" version="1">MLRSEDMEHVTLYFSKDTAKQAITELGNHEMVHFIDQNASLKTERLPFTREIRYLEKLLSRVSYLNNETVKLTPLAKTAARCRSLDLGEVEAQINKHYIRYAQLRDLQNDTFSNLSRLQEDMAILQTVEPLIDANNKEHFVAGIINKEKSFLLEKILWHSLRRNLVIHTFDFESEELPKKVIFLVFTHFKAKSKTTQICTSLSARIINLNEKRYASQNFLNMASLIGQIKAVYQNNVMTLKSESLCISQQIPLWKYFLKKEIKIYEIMNQLTLSQQRDHLVGEGWILKRNVERLAKIMTFISEIHGYTAYEIKGVITSLQGNKSPSPLTNSKLEKNLGLENKEIENYSRFEENPRFEESGDKQSGDKEKIGIKEKIKNKENPNQPNKENQNKENQQKNRNQKNNENNEKPKFSSLPTHNIDIITDPNTPLSTEPTQPPTFIETNEFTHAFQTITNVYGIPSYKEINPAIFNIFTFPVMFGIMFGDVGHGLILLFISLFFIRYKSKLDNFHEATQILVDGRYLVLCAALSSIFFGFLYSDFLSLSIPLFPSQYTVDYIYPFGIDPAWHHSTTGLMFVNSLKMKMSLIFGFCHMLLGMGICYCNFYYRKSFLDIFGVWLPQFLCFVGFVGYLVFLIIYKWLVTYDYPSLISVLVGMFTSPFHVENSMYPGQVYVQGFIFIILCVTFPWMFFAKPLILTHRKSKDLVDVWMHQAISTIEFGIGLISNTSSYLRLWAVSLAHSQLTQVLHTMTLGANNFIVRIFTFPIWLLATAILLIGLEGLSSCLHALRLNWIEFNSKFYEGHGYDFKPLNFMENDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7T7</accession>
    <name>A0A4Q9L7T7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FYR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0236p0010</name>
        <name evidence="5" type="ORF">CWI38_0005p0110</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000236">
        <property type="protein sequence ID" value="TBU03769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7T7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0236p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0110"/>
    <dbReference type="OrthoDB" id="2192852at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24252" checksum="B559646040180C87" modified="2019-07-31" version="1">MVTIQEISKFIAEKFVKNYTKKTHLYEERNELEIEIANLEVKKNAFIDILKPESISESTDKKIFPLILGTPALRMSITTLGSLPTHDHIKFHNKNTIYPIGYQCKRKYKPHNRYTKNNQDKIFYFCTVKDTDHILEISTNDGRKWTGIDLWGLFVQDFDEVTEYGNVDEFFGLNHPTVQKMIEELGDISVFVNYLPLKERKDKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7X8</accession>
    <name>A0A4Q9L7X8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0313p0010</name>
        <name evidence="9" type="ORF">CWI38_2286p0010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000313">
        <property type="protein sequence ID" value="TBU03325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002286">
        <property type="protein sequence ID" value="TBU08256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7X8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7X8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0313p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2286p0010"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000062">
        <property type="entry name" value="Nuclear transcription factor Y subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU08256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="148" mass="17401" checksum="F504CC3C7DC8FDC8" modified="2019-07-31" version="1">MNPNHLPSKQSSKTIIERFWHTSIDKAEHEPPNYKDFQLPLARIKRLMKVEEEVKMVASEVPILFSKVAEVFIEELTLRAWLNTEENKRRILQKNDLSAAVKTSDMFDFLIYIIPRSDLGQSLEQYDESEYGEQKKFNDRGGIEEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBZ0</accession>
    <name>A0A4Q9LBZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0078p0020</name>
        <name evidence="3" type="ORF">CWI38_1528p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000078">
        <property type="protein sequence ID" value="TBU04865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001528">
        <property type="protein sequence ID" value="TBU10825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0078p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1528p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="234" mass="26550" checksum="E8E033AD46BC409B" modified="2019-07-31" version="1">MTKPIILISSSLLAVLLALGIFGFISYRSANKFIENLESDYKKISESVTFKNFAALLKKEKIAMFTPNDDKINFNVLLTNDENDRNALLEALKAQKIDDFVQIKENLPKEDPNDVVTMEKPSLPDDPGFFAKVGLLLKKKQTMVSVKKLTAFIKARLDVPHDENSTWIVFLNILDKIAVESFCVEIENKKVKSISKSLSFTIDRLDEKNTDEIADFIAYIIEKNRKKDANEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFB0</accession>
    <name>A0A4Q9LFB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5093 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2627p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002627">
        <property type="protein sequence ID" value="TBU06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2627p0010"/>
    <dbReference type="OrthoDB" id="2192698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031533">
        <property type="entry name" value="DUF5093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17011">
        <property type="entry name" value="DUF5093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14944" checksum="330045181E0ECA49" modified="2019-07-31" version="1">MESQIKIIFPYKIENRNNSFTIPSKILRKSNIVIIVIPFDLDLYISNTKLIDKRCINKCFSYSFEFLDISSPLVFLKDPTIYVVENFVPTNSTVLENEMNRFMEEYEGNEKKENKEIVDDEGFITIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFE9</accession>
    <name>A0A4Q9LFE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2514p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002514">
        <property type="protein sequence ID" value="TBU06743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2514p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6845" checksum="A725A63335F9F805" modified="2019-07-31" version="1">MQILMSVDTYIQSIVPKKTVQTIFFDRRRGLESGPNADERWERALMGTKTPFKRSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFV4</accession>
    <name>A0A4Q9LFV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2658p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002658">
        <property type="protein sequence ID" value="TBU06021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2658p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18255" checksum="6F4EBB2115B1393E" modified="2019-07-31" version="1" fragment="single">NQSTTLSNKEPSIEKTNNYNFNKKKVKTSNSKNSEKVKKVKITSSKENKDIQIYKKNEDSEIDIYDNFIFTRKKNVRNIKFYTGVWFNPNENRKRVSLKFVKIPNKKSILRANQTLFQTGKVKKQIDDSNDIFISRQGKRIDGLSLLGLLEESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG52</accession>
    <name>A0A4Q9LG52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrP8 U6-snRNA-interacting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2460p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002460">
        <property type="protein sequence ID" value="TBU07059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG52"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LG52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2460p0010"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding" evidence="2">
        <location>
            <begin position="247"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="819" mass="91317" checksum="8CA6A47436D6835C" modified="2019-07-31" version="1" fragment="single">NNTNRYPLNNTTSYHPLNNTNRYPLNNNTYTYHPLNNTNTYHPLSNTTNTYHPLTTSLTTPNLLKFRGKLSHLLNKGLPRINTIYNKDKDIRCYDKGYRIRGIYKKYNCKYDYLYFTDIRHDGKIYDVSSYSSECVIKLGGYKEIYKHTLYSCIFGRDDSREVGGDSVRGSEVGGVSNRGRVVGGYSNRGSAVGGVNSSTSNYNPVNSITSNYHPLTNTTSNYHPLTTTTNITHTNTNNHTITPHTTIPLISLHTLSAFEESMKYKKLTLAQQQGINILPNKRFIFWWSPTLNRSNVYIGYCIELEQTEIKMYGKLNTLKTCYLQVFRNSLWSKIQRSITREVSRYMMEGCDMVGGDMEGGDVEGGDMVEGYSSGVSNSNSGVSNKSSNSNTSNNSVSYKSSNSNSNTSNSNSNNPSYTSNNTTNNNPTNNNPSITIIDNDSCIVVKRVLKDLEIGYYDTIGNSVKDSVSRVSNKDGVNDGVSSRDSVSSRDSVSSRDNKDYKDYKDINDIKDSVMNNPNIQPTPNHNPIDTSSSDTVTSDNLIDTNPNPNINTANPNPNIIPNPINTITCNTLLIKVFLLWGDYDNSNIRNYTYYKYKTLENSGIGGSKIGGRDKGNISNTNNTYTNTYTNNTYTNNTLNNNTLCLVLAVDLLYNTFSSYGYTNIYIKNILKNIKTIINNNRCIRIMKERIKKVLNIGLEVEEGVKGVNNIEIYKCDVIVDDEGVNRKGKGYVVIYIVGKGVLYVMWVNGCYEGDIGEYIARGVIGIIEREYNMLGGDSEGMDVSIEGNIKGVSEGMGSGKLGGVSRLEGNIKGVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGG9</accession>
    <name>A0A4Q9LGG9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2453p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002453">
        <property type="protein sequence ID" value="TBU07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2453p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020179892" evidence="1">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="334" mass="38853" checksum="8BC2CC0A933EF735" modified="2019-07-31" version="1" fragment="single">MLFKKYFFLVFWSLTKTAVQDKVSELSTDLEKTKNGLKSRLIVTVFGNDLDKKFSIRKHPEMDFYPETTDSKNENRCNPPNHYILSISDCVLVSQKFYISHDSDIPIAIDYFVDCSENPSYIYQPHINTSSLETITNQTHNTDIESSIGVKTNKTKKPINISHDYAFKYIIKMCNGNENIQNPLNLFKKIENIFECVKKQNFDEQNFDLESLFKSNCFVFVCLNVIEKKMKEDLKCEAFFKCISESLIKRMRCIEIARQNCPILSLFPGLIFLKDFIFDQISKKPIKEISISSIFYGLKTIEIILQSPSLSFPVVNSKVLYNYNSKYTEYKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGN2</accession>
    <name>A0A4Q9LGN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2490p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002490">
        <property type="protein sequence ID" value="TBU06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2490p0010"/>
    <dbReference type="OrthoDB" id="2196381at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="564" mass="67500" checksum="FCF3EEB92897CC54" modified="2019-07-31" version="1">MDSQKEKRQSQTSHDHSTKIIKRMTNISETTNENMNENCTCKIESFSYKIQEAENIFQPKKTSTCAKNYFKENIHIQMVFRMKLAQTNPNIFLKAQNVAHESHKPITMYDFSIIYLNFLTAINIGPERNSIIIFDLNVFSAVFDTNYSDNLIDKFIKKLIDDPILYNKEERNIFIIILLIVLIYTIRNNFEKYTVLLKRKIYDNSHLYEFVRCNFYYFYTKDITIDKLLLRCDPLLDLRQESIFLNFFYKKYFLKDKIDENLLLLFQKRILTKLKKIDGNHVFTFLKNIFLYETVIYDISTKENVLKVIVSFYSTVLNLKIKETVVQSIFNILEIVFTIFSVEDTCFQTIGNGIINFPLTNKTTLKYTYLWKIRMSLDFDDLKCLIQEYKDNFTYLMLYFDEIFGIFSIIDLVDICLENICKCIEYIVYTFEDIKIEFNLKYITEYIKYLTILFVKINKKMEAMKITDYQILKNLNFNTWNKISKIILISHKFIYKQIEVESKKKKTINRKSNVFDKYLLSLVKAIRDSESKIMIFTQENNIEENIIRVKYQSLIVNEIPETEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHG6</accession>
    <name>A0A4Q9LHG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2433p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002433">
        <property type="protein sequence ID" value="TBU07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2433p0010"/>
    <dbReference type="OrthoDB" id="10055437at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="810" mass="90486" checksum="9C0972F21638E086" modified="2019-07-31" version="1" fragment="single">TSKQDPINSKTYKQYPFISSTYKQDPVNNTTNNYHPVNKSTKQHPFKRVIYCMEGNTQHSLMEDCRIIYGEQEYSYNNIYKTYRDIIREEGVSNRSKGLERGVSNRSKGLERGVSNRSKGLERGVSNRSKGLERGVSIIEGRERGVSNRSKGLERGVSIIEGREGGVNIVEGREGGVNSKKKGVSNASIREGGVNIVEGKNRGVNSKKKGVSNSNKYKGSRYRGVNYKTLSIRGVNDKSFSITPLSNTSPHITPLSNTFPHITPVKTKSFSITPLIKTSPHITSVKTKSYSITPVSNTSPYITPLNTKSYSITPVNTTTLYSILKYSFIYSLEIRCVILHSYICYISCYIPYTLSFNYEWSLKDLLLFIRCCKYMTFKESIGVVYGSRLSYKEVICIEIVGDIIKGGVSSMDIVEEGVSSKDIVEGVSNKDIVEEGVSSMDIVEEGVSYKDIVEGVSYKDIVEGVSSMDIVEEGVSSMDIVECVNNSRDIKEGGVSKGSMLEGVSSMDIVEGVNNSRDIKEGGVSYKDIVEGVSSMDVVEGVSYKDIVEGVSKGTSNYKGVINSTNKQHPVNNITDTYHPLNDSTDTYHPVNNSTDNTPSYTWLFTYYDILKDKLKGKEYEIINNKEITSKNKKDNKDTNKGLDSHDINKGFINKELTSKSNKDTNKDNKGLINKELTSNYNKDINGFINKELTSNDINNQSCKLSPFSIKVRFYKAIVVEEGVNYSNIDNVCYLLIKEVNSSNKKEWVWVVNKGVIDKVYVSSIKGCYYSVYVGIKGVIVFRSSSDKRGIKGVIVFRSSRISNRDKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIQ0</accession>
    <name>A0A4Q9LIQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2364p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002364">
        <property type="protein sequence ID" value="TBU07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2364p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12605" checksum="80BC684604A7B753" modified="2019-07-31" version="1">MPEENTKGNNFYNYDSPTNKIGRSPFRKQFKRINPIKMTLLKDKEEFLNRMRNEMEKFNSKEETSIISNSDDIIGTDILDNKSTFTECNVHSEEGDSKEFEDIKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ89</accession>
    <name>A0A4Q9LJ89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0303p0040</name>
        <name evidence="3" type="ORF">CWI38_2309p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000303">
        <property type="protein sequence ID" value="TBU03389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002309">
        <property type="protein sequence ID" value="TBU08077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0303p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2309p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="138" mass="16358" checksum="3CF729DB0939CCBD" modified="2019-07-31" version="1">MKNILIYFCLHLHVLIFHFHYIYCEKVSKSKGHEISSGRKHEINQTNKIQNSTLKNKDLEIKRFNVQNMFEKGFPMNDILIEEKIPNNKKMTHITSNQTSLKNKYSDSRNNQNIDKQLKLIDELNISSKYYDALKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKK9</accession>
    <name>A0A4Q9LKK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2373p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002373">
        <property type="protein sequence ID" value="TBU07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2373p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="39353" checksum="7DDF91EF9B592F19" modified="2019-07-31" version="1" fragment="single">ENIIKKILCALNNHLEGKMCKPKEKIVINNGTNFIYEDISKLFRYFHYYINNFKNENLNIESIKKIFSKSLDFQMNATNFLSQKTFIFICRGKIPNLDIFLFKKIIFKYLKVRNTSFMTPVFFFDSSSNNLKNDGYFLSSSDTSNTFCTVKFYYEKIVSSEYIIYFQNLKELKAFFVSEELFLKYSAIKFTEKIEENFHDMQNQSILSLKSMPTRRVDVDFVNPIRKDIVMVVNNIFSIEYINKGYFFEKKIKKDDFTLKNKCFIQSMELSAHIDRVDSFAYNFCIDEYGEIISTYREELKLYANIKNISIAFHEIEEKCKNLILSLMNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKL3</accession>
    <name>A0A4Q9LKL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2262p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002262">
        <property type="protein sequence ID" value="TBU08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2262p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18234" checksum="DA892AE9509CEF95" modified="2019-07-31" version="1" fragment="single">NEYAEIRVDTRIKTDITLIEVGITSQDSLQIYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPINVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWESASMGVIRRAEKHEEPTPPLKEEKREEDGSDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLX0</accession>
    <name>A0A4Q9LLX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2160p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002160">
        <property type="protein sequence ID" value="TBU09329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLX0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2160p0010"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU09329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="35455" checksum="795B0F379BF222BC" modified="2019-07-31" version="1">MLQKKVKLNNGKEIPIIGLGTWRINGKEYIRNSITSALEIGYRHIDTAWVYENEQDIGIILSDILQNKKFNIKREDLFITSKLWNTFHHNVKEGVIQTLRNLKLEYLDLYLVHWPVSFKSKNNYETDRDKDGNPILLDFDPVSVWKQMEELVESGLTKSIGVANFGTQNLTKILENCRIKPVINQFELHPYLKQTDLQNFCTNHNIQIQSYSSLGSSDNENTAPNLKEDPILSKLAQNRNITTSQLILSYLTHKNICVIPKSTNPTHIHQNSQLIPLTDQEVQQIESIKTEYRYVDLPSFGKDRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNQ3</accession>
    <name>A0A4Q9LNQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2046p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002046">
        <property type="protein sequence ID" value="TBU10073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2046p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25426" checksum="07208EFA001ACCAF" modified="2019-07-31" version="1">MSHNNSKDSWSDYNFKSSENNAEIKPEKRKISETIDKNIFEQKQSDKGDNNDWSTGATYSSWDVNKSSSKDTEKEANTFNDWSVDAQLINEKISEYSQQEGTFTGWNTDQGWSTNQNTDWNTNQNTGWDSNQPTDWNTNQPTDWNTNQATGWNTDEKNEYQNTEQSWDINHNISMHVNPSNEWAIHSTKTLLGVRKYKLDIKSIYDGEKLLTEGKKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNU3</accession>
    <name>A0A4Q9LNU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2049p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002049">
        <property type="protein sequence ID" value="TBU10069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2049p0020"/>
    <dbReference type="OrthoDB" id="7480412at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="533"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="694" mass="79686" checksum="DB3CEA99B2ACCA94" modified="2019-07-31" version="1" fragment="single">MLITKDTIIGILKYIMGRRKKVDSENIRNEKIKAILMCDVDVAMLSERLPHPPTFHNTTHQPPSPNGMTNLNTDAILEGNRLMVLHSILDSVTVIEQEWPRTAILAVQKRFERMPRNGWPATLRYYNEKFSYTLDIDAFKKLAQNEAESEIRQEENGERCRIATCLTEPCTLTDTTEYINPRDKALSKIKEISGKNFKKVVVRTRKLSSESYADSCVPMSLTAVARIIPAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKHSTSETKSLKKIMREFNLNLSSVNDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFDLFRGRFYRGLSERVESEHVVSRDKNVSFWSTMWNENDDTVTYDDYLIPFVSDNHPTTFPLFDEFVNISNWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGKPQADWFYCGLTYLIPKGIPRRGSEYRSITCMSNLYKLTTKCVTKVVQLEVERRGLLAENQLEAQALLNIALNKEYGNNLKATWIDKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLKGISVYKYLGIIEDSRGIPTPSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPK0</accession>
    <name>A0A4Q9LPK0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2083p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002083">
        <property type="protein sequence ID" value="TBU09956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2083p0010"/>
    <dbReference type="OrthoDB" id="7457938at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1297" mass="147460" checksum="39A3F58E30789EEC" modified="2019-07-31" version="1" fragment="single">YHPLNNNSTNYHPLNTNTYNQHPFNNNLTIVLNIRKPKISISKYVLREMGFILINQSINIKCKEIILTSVICMKNKFNLQVKDLEIFIFKNRIKEYIVNKIPIEITGSIVDTVIGCYDIGKGEGSGVEGVNDKGSVLEGVKDTGSMEGGVSDRGSKQQGVKDTGSMEGGVSDRGSKQQGVSDSSVLEGVNDSTSKQEGFNYTTDVQDPVNNTTNQQHPFNNLPNQQNPFNNTTLSVLHLDSCIDKLRIKIPKDLLFIRSSNIKGVNNNTGNLHPVNNNTTYYPVNNSNNNQHPFSNNTDIQHPFSNNTYNQHPLNNNTYNQHPLNNNTYNQHPLNNTRLTFNLSINNLILDLPFISYKLKGKEITLVSNLNVEIFTFNFNIKGNKLKGCYRRDKWTKNIFYNFNDFRFKGNEYVVKLKKEIEEMLMFIKGGRDNSVLGGVNDKSRIEGVNNKDRIEDVNDKDTEQHPFSISSNQQHPVNYTIDKQHPVNYTTHKQHPFSNSSNQQHPVNYTIDKQHPVNYTTHKQHPFSNSSNQEHPVNYTTDKQHPVNYTTDKQHPVNYTTDKQHPVNYTTDKQHPVNYTTHKQHPVNNSTYNQDPINNTLLFTNLRLNIITPLISILIKVKEIKNKNIKKILIKTNNTLLNISKISLINNTITNIRIIKDESTDKDIFYILQFLKELEIIPFTSKSSEEEVFIIRNVKIISYFSLSLYSKVIFKSKNIYILFKKDSLRIEIPISIGVNDSGLEGFSDSSRLEGVNDSGIEGVIDSSRLEGVNLSNYNYKGVNISTNKQHPFNTNNTTQHPFNTNNTTQHPFNTTINTQHPSNTNNTTQHPFNTTINTQHPFNTTINTLNVSLVILKDTNGLIITPVITGSIDNEFYRILTRNILEIIEITLNIIDCLLIKSKETTFNFNILPLVCVRLYCIIGNSVIELGVLDSSIEIKGVSGNSFIKEEGGVNDTGVDNDRGNGLEGVNDKDILEGVNNKSSNYKEEWGVSDKSSNIKGVRDKSTNIKGVSDKSNKDSYKGSYKDSYKDSYKDSYKDSYKDSYKDSYKDSNKDSYKDSYKDSYKGSYKGSNKDSYKDSYKGSYKSNKELLDALLKGVNNNTNNYNNNTTNNTSNTTPLDVISTDFIYQQFIKNYPLIDILTPFLLLTINIKEISLKPIKYYCNIKGVSDRGSGLEYVRGVNDKSNDYNQEEGVSDRDIDEGVNYKSNDYKDIRGVSDRDIDEGVNYKSNDYKDIRGVSDKYNQEEGVSDRDIDEGVNYKSNDYKDIRGVSDRDIDEGVNYKSNDYKDIRGVSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPK4</accession>
    <name>A0A4Q9LPK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DSHCT domain-containing RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2147p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002147">
        <property type="protein sequence ID" value="TBU09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPK4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2147p0010"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="211"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126193" checksum="67F466FF3E07EB5B" modified="2019-07-31" version="1" fragment="single">SSYKGDIDTGSSYKGDIDRGSKQQGVNYKDSNYKGDNYKDSSYKGDIDTGSSYKGDIDTGSSYKGDIDRGSKQQGVNYKDSSYKGDIDRGSSYKGDIDRGSKQQGVNYKDSSYKGVNNLSNKQQGVNNLSNKQHPSNNQNTITTNPTNTTNNNNTFFDRKAFTSVVKSIKRSKRIESKNIFQITETLIQNNNLPAIFFSFSRKDCEKHALSIEQDFLNSEEKKMIKIIFSNALSTLRTEDRNLPLITNILPLLMKGIGIHHSGLLPILKEVIEILFQENLLKILFATETFSIGLNMPAKTVIFTSLYKFDGILKRILSSGEYIQMSGRAGRRGLDDKGIVIVMLGDTIEEEEGVKLFSGVCDRLDSAFYLSYNMVLNLMRVEGLDPLFLLGRSFYHFQNIYKREEVFKEIKKIRHIIDKYEYECGGGSGSGGSGSGGSGSRDSGSGDSGSSRDSGSSRDSGSRDSGSGDSGSGDSGSNRDSSNSSSNRYNSISVSNNQPNTTIINHLPLLCLERERLLIERSVSLQEVFKPYLKVGRLLNIFIPREGATLFINAIIITGGDSSRGKGRVSGRVNNNHISNSNSISNNNNHISNSNPISNPNPISNNNNNNPNTNTNTNTLSVHAFMRGGIKRMQINKTCINNIYDIRVKEDFIFKENNKIPFINIKSEYDYKIYEIESEINRYESGIESKGYESKGYESISESKGYESKGYESKVYESKGYESKGYESKVYESKGYESKGYESKGYESISKGINRYESKGYDSISKGCYLCGREYIVSKCIEGICYDPIAEYDSMDSMLDSSIRDRDSICNRDRDSSNTNTSNRVRDSIRYDNTNTNKTSNTTNTNKRSNTNNNNIYTNNNLYTNTTNNNIYTNNNLYTPTSTNTNNTPTTPTPLILLKHFRLLYSKNLIIRKYNTLNSLNEIYHMEDCKKMISVLRRLEYCDINNKVLVKGRVACEISSSDELILTEMIFNGDFISLGVDEIVPLLSCMVFSEWEENNDLELSEQNNKTYRLLKGTVDKISKVMSECGLYVDIQCYYKRFSYELMDVVRMWVLGFTFSEICCKTNVFEGSIIRCFRRLEELMRQLSCAARGIGNSELEGIFSLGVSKIKRDIVFASSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPP3</accession>
    <name>A0A4Q9LPP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1749p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001749">
        <property type="protein sequence ID" value="TBU10453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1749p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="33044" checksum="AA46EBB61E7B57BF" modified="2019-07-31" version="1" fragment="single">DSEDIKNKNISTEIQNNDINEDLIEKNEVRVWRGSYECFPSIILHIFIFLRKEVKIEWYYKHSCLLHSFISIVFYNEFFKRRYSVIYIIFSYTTGLFIFSLGKRYFGQKNIKYVFLFYVSFNLFYCITSYMLLRRYIKAEGILMRISVFIEKRYNVLLRTIYFLYVLLLLIPILIVFHCNNLRFRIVEKLRVSMFVVSITFLLVLYPKTLFNKVILIMLILKNLHLMLCIYFLDNSYDNGLCISNNLLICYTGIVYQTSSYIFEKYFVSDKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPW1</accession>
    <name>A0A4Q9LPW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1733p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001733">
        <property type="protein sequence ID" value="TBU10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1733p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020226533" evidence="2">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="115" mass="13390" checksum="C94BE4ADABCC6287" modified="2019-07-31" version="1">MNVLSILVFILDIYATEKKKDENFSKNPSSSDSTQREAESSTKFSKKKLPDILIHQELIEDVKLLFSTYEKADSIGLKLYQWFKELFDNDYYTKEICTILKEALKKMKALLAVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ5</accession>
    <name>A0A4Q9LQQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock factor-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1495p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001495">
        <property type="protein sequence ID" value="TBU10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1495p0010"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38885" checksum="645091C4A5BFF229" modified="2019-07-31" version="1">MKKSFDLNLKINKIPKFIKRLYKVVNEPTIKEIYWNDNGNSIIIPKKEEFIKNVLCLVSKTREYSGFIRQLNNYGFTKVRGYTDECEEYFNKNFLRNREELLNLIGRSKEKSGSTADIMNSYRQECYSLRNNVEYLNNSNYMLTKEVENLKARMEKQDRTMNGLIEVLTRAFRFGMKNENPQLAFSENKTHSELDKFLSEDLVDSSYELNTINQPVKNTISSDITSYGLNSINSPVENAISPDIKNMILKQNETTKYNNKSHKSAPLNHILAEEEHRNNTIQNPAINSTPSPLFDMPIFQSSKETTPNHQKRNKRKSQDKDILENDLDFDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQS0</accession>
    <name>A0A4Q9LQS0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1584p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001584">
        <property type="protein sequence ID" value="TBU10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1584p0010"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12972" checksum="2D22600BA971E5AB" modified="2019-07-31" version="1" fragment="single">WNIKFKAQPANSPDLNVLDLGFFNSIQSLQHEASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHLSKGKLRREGRLLEKYVCSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT9</accession>
    <name>A0A4Q9LQT9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1574p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001574">
        <property type="protein sequence ID" value="TBU10744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1574p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="115" mass="13786" checksum="1EE36DDACF476F76" modified="2019-07-31" version="1" fragment="single">MIFNQIRANIYFFILYILLQFLTIQTEIIVRFHLKNDSIKKVEESDRKFIEKKSFLNFCSKFLTVKKESVVKNVKIVKILISDLILLNCKEIEFHKKNDGLEIDIDLSKIYYSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC4</accession>
    <name>A0A4Q9LSC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1774p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001774">
        <property type="protein sequence ID" value="TBU10420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1774p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="8300" checksum="F64EB8328E3C2156" modified="2019-07-31" version="1" fragment="single">MNPLLETLSTFYLSKITSKRIFNVPRPPTCLKMTRRQEDIALKSLHTCTDTYWFNLLIQRYFAELRTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE3</accession>
    <name>A0A4Q9LSE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small Ras GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0512p0040</name>
        <name evidence="10" type="ORF">CWI38_0277p0050</name>
        <name evidence="9" type="ORF">CWI38_1742p0020</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000512">
        <property type="protein sequence ID" value="TBU02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001742">
        <property type="protein sequence ID" value="TBU10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000277">
        <property type="protein sequence ID" value="TBU17636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0512p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0277p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1742p0020"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU17636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="223" mass="25357" checksum="2F703D9213913517" modified="2019-07-31" version="1">MARTERDLYAFKVVLIGDGGTGKTTYINRVRQGGFIKDYVATVGAVVHEVRFTISEQHDILFYVWDTAGQEMHSILNETYYLDADGAIIMFDITSRITFTHVPFWLQKLRNVSSLNNNEVPVVVCGNKVDIKDRKVKAKQIMEGLSRDILHYTDISAKSNYNFEVPFLVLARRLTGINNLVFLANISLAPAEVSMSEEALRESMNVMQDVYRARTIELPEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK6</accession>
    <name>A0A4Q9LSK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1382p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001382">
        <property type="protein sequence ID" value="TBU11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1382p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="36238" checksum="EF20B3ABCB36DE28" modified="2019-07-31" version="1">MKSITERIFHTFLVGLDNLNSVFPQLSIYDSKINENFLTEEIRNNEFLKLIKYVYQINKWECSKYYDNAVLSKENLIVRWGCFNMLLIALCNKYTPENPNNISYRKEVGFFVDLNDYHGPVLFKADDNCIFSKGLITAYTETYRVLLRANSDRDFYISFYLEIQNWLFVFIEDIFPKLGLETFFYTLTLCFPIFDEIIFKEFFVSFLEKNKFEIEISQEEDKSEIFTEMKTNLLHLFSYFFETTMNECFKEEDGVKHLKTKNNTLFISEEETALDELKININTDSGLEKEKIVCKRGRIKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM4</accession>
    <name>A0A4Q9LSM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1129p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001129">
        <property type="protein sequence ID" value="TBU11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1129p0020"/>
    <dbReference type="OrthoDB" id="2428500at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="150"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="35379" checksum="888833889B4F0D3F" modified="2019-07-31" version="1">MYRCLIEISISNDENLLLTTIPTLRKQKVSINDRERIIENTLEGYSMSAIASMYRINYQTVNSIVRRHSKTGLVFVEKRGGDRRSKLTLEIKESLQTYVDLDVDVLTSTIDRALREFHYTLKRVTLVPEPKNQLSTSFRELEVDNDDKNLFFLDEVLFAVVTRPSRGRNMRSGSAYLSVTALRGRNISVVAAMNKYGRIYHKIHERAVNGEDFKLFIKEINESCQRIHHYRGLNDDEEIASYRIKYFPPYSPFLNPIENVFSPQLRILIYEKFNEITGEHCSSFYRKMLGYLQKAEVGQMIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSU5</accession>
    <name>A0A4Q9LSU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1322p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001322">
        <property type="protein sequence ID" value="TBU11206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1322p0010"/>
    <dbReference type="OrthoDB" id="2187336at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="5">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13997" checksum="1BABE6AE845DAD64" modified="2019-07-31" version="1">MLKSLNYIKSLFSFKRNTETKIKENLIKTVPLTLSIISPRSMFTNDFFKKEFFANFFKSLYIFAFKPFGINDIVKVHGYEGKVDCLDWFYLRILKKDKSCVYIPTSSLYNSVIEIYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY7</accession>
    <name>A0A4Q9LSY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1514p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001514">
        <property type="protein sequence ID" value="TBU10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1514p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="568" mass="65255" checksum="94F5A8472B66455F" modified="2019-07-31" version="1">MSKKIDRGILQGDSLSPLLFVLCMDPLSRKLSEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLKVIGLEINKDKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRAHLKKLNVKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDVVRAVLRLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKRIEISTRRVAILKVGNNNKTHLALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNVGNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINKTVEMISFDRRRGIESGPSAEESWESASLSVIIGAEMHKQPKPPLKEVKNEEDSVKLVNSKNNLPLILDDVTRPEEPTIDINDKLDVEKENNWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT82</accession>
    <name>A0A4Q9LT82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1028p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001028">
        <property type="protein sequence ID" value="TBU11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1028p0020"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="16261" checksum="40408D1A363E7663" modified="2019-07-31" version="1">MISRQRRFFGKRLNRINIKAINRNAISLLNYHIRVLRLKPADFSKLDERVSEALVNYKLHLRPRCKERLYLPRKELGRSLHSVELRSKHMLQELINPTILKMENTNETNLAQKKRQKSKKSLEEAQLAKLYNEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF3</accession>
    <name>A0A4Q9LTF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0991p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000991">
        <property type="protein sequence ID" value="TBU11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0991p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="458"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="853" mass="97410" checksum="762D2FE9DB9F0658" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEAKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDFVKADPKEWPRIVFLRTDKLHRYYNEKFGCTLDIDAFKKLAQNEAEREIRQEENRERRRIATCLTEPCSLTENTEYIKSRDKFLNKIQEISEKKIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAVQICYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLAENQLGAVRGVQGPKERALLNIALNKEYGNNLKATWIDVIISKWKIDISVGPEKIMSKKIERGILQKDSLSPLLFVLCMDPLSRKLNEKYTKLTVKTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKKFLEVIGLEINKEKSATHDTCCEDTATLLEGVSVYKYLGIKDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVFRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKSHLALIKGFLKVKYRLVEEVTKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF8</accession>
    <name>A0A4Q9LTF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1207p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001207">
        <property type="protein sequence ID" value="TBU11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1207p0030"/>
    <dbReference type="OrthoDB" id="2186513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17350" checksum="2A210B7BC5C71438" modified="2019-07-31" version="1">METEYSIAHSGINRMIALIGKKYYGIPRTFIIKYAKVYGACSRFNYLKKIQKIYMKNITNTNDIFMIDCVNLRKYANQKDGIVGPEKKEETNDAVMSDEEISYEVLTAIKNDPECAQLNLDIASEMYNEINEYINNMVELENFNGEKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ8</accession>
    <name>A0A4Q9LTQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0719p0010</name>
        <name evidence="1" type="ORF">CWI38_0993p0030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000993">
        <property type="protein sequence ID" value="TBU11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000719">
        <property type="protein sequence ID" value="TBU12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0719p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0993p0030"/>
    <dbReference type="OrthoDB" id="2189571at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15825" checksum="B2EE2DDD0EE66C74" modified="2019-07-31" version="1">MINGFVLKKKGRESKAAEIFQILKEKLPKNKKFKNSVKIQTYGIKRDGWIQCTSEENLKIIILEIITISNVKRVIIDSICTLYLDNGLYLHFKALNIAGVDVVLVIYKFNKWADSFLVHTNDKWIKNKSKKREIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS5</accession>
    <name>A0A4Q9LTS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1069p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001069">
        <property type="protein sequence ID" value="TBU11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1069p0010"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21156" checksum="327077DF6C027648" modified="2019-07-31" version="1">MKFVNENEAQAALGLLKMVQCDEIEKEGTARSKGKFELEILSEYFNITAYPSYETRYDIAILLNISPKSLINEGNSQRIKFGSSNISMTNYKACIYNILSHIRRYNRYSEIQYSGYSKSKKLLKFEFSKIIFLILVNNTYLVLLFSTLISQRGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ8</accession>
    <name>A0A4Q9LTZ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1418p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001418">
        <property type="protein sequence ID" value="TBU11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1418p0010"/>
    <dbReference type="OrthoDB" id="2189774at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="655"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="874"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1096"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1157" mass="129023" checksum="F379AA5D942C1ABD" modified="2019-07-31" version="1" fragment="single">MHNKPNPDERKKNLIKLFNALKSSPFSNTHALEQIREAAIKAEQISFEQSKTIEEYLYKMNEKYCKITKMTQNPTHMHSSKQTESNYNISESSTKSSTSSNSSNPYIANPSNPYIANPSNPYIANPSNPSNSYNTTNPSISSNPYTTTNPSNPYIANPSAHPPNPSNTSTPYTDTFSIPRHPLQNNFHPQQIFYNQNNSSYNNSQPLHANIPFYTVSGSRSHLSNINNIKKGFYTGNSNSGANSSVNSINCGVSSSGSANGINSSVNGNNSSGNNNSVNNNGNPYTTSNTNPYNANNTNPYNNTNYNTNQYGSKPNPYTTYPYNNIYPNPSPNPNQCINNTSNNPINTNPYNNTLTNNTPYSINPYSTNNNLYSHINNTSISLSNQLYKQNPNINTEHIMNNSNYYPVFNSNISKKTRYFKSKINPVNVEIKRNSNYLKGSEEGGDNCSGNGYGNNGYADSINNTPYNSAGNNTSYNSAGNNTPNSNTYNSNPNSNTYNNTPNSNTYNNTPLNTNPYNNTNPNSNTYNNTPYSNTTNNTPLNTTPYNNTNPNPTIINTSNTTNPNTTTINTPLNTNHNTTNINTPFIYQHNTINRHPSIFNEMPEFLRYNDIPQESNKTIKTVKSPVIKIDRQHMYSKEGVKYTEQEIKHNNEINSNNGSYSNNGYNSTVNNTSSSNPYNNTPLNNTTTNPYSNTPLNNTTNPYNNTPLNNTSTNSYTNTPLNNNTTNPYSNTPLNNTNTPYSNTPLNNRIERDIYNTNYRQNISQQQDTNTITSPRKRGRKSKLSPSLKKIQNISSYSENNLDSKDNGVSSNSSVNMFDRIMGNHFDTTRGVNNKDSSLKGVSSNYYTGNDLYGSNTSTSQYNNTSLFTNGINNTPSTNPYNNTTTNPYNNTPSTNPHNNTSSTNPYTNTPSTNPYNNTPITNPNLLNTSQYNNTPTNPYNNTPYNSTFISTKNKVVICKKVEEIKEEETWKLQEKNLSRSLTSQDKRVDNIETVTKKVELKVVELSRKEIVEKVLKEIEDLEEEYGGYKDYCGDNDGEDSEGEGEGILTPDDLMDRLIEERRVFFEEGIGIKMVKGFNIIEEGDNDIEDGLEGVSDKDNRGDDVSSKEEGVSDREGVLESVSNTIDKLEGFGDKDMLEGVNNTIDYLEGVSNCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU21</accession>
    <name>A0A4Q9LU21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0106p0040</name>
        <name evidence="2" type="ORF">CWI38_1382p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000106">
        <property type="protein sequence ID" value="TBU04649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001382">
        <property type="protein sequence ID" value="TBU11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0106p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1382p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="145" mass="17024" checksum="1179212ED536910D" modified="2019-07-31" version="1">MNIFIILLFRKILSSRISKEGNKIGFTKDEVKQRPVDRSSTSDNNIKRYLHIIVTNKNQNLIDDTSLAIPYVKKFLEAHLKKIISLIEECIEESIERQKIQRVNDGNLINEKTIYKSICSIYSEILREKYINFCSEQKCLNNKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU22</accession>
    <name>A0A4Q9LU22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0882p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000882">
        <property type="protein sequence ID" value="TBU12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0882p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020179894" evidence="1">
        <location>
            <begin position="18"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="578" mass="69408" checksum="DE51E584A64A5D37" modified="2019-07-31" version="1">MLLGFILLLLFGLSSNASFIESEDENIDVETIENTDISEWKPMCIPNTENTMERFDGSFASKKSIKDIHSRRLKNDMPLREKIKFRLDEVLKDFELHYEYLTISNIERYTYILSKYEYQVYCSFEVLKKNLYENKKTTAFSFKYMHEEILTDFVDVENLYLNIKKCLILIYKIYRFFLLENEQFGSLESIYMEQDNQNPDFILTLFTDLEFANIICQMNKEVEKLNSGENFEHDYKKLKLEYRDCEAKICVYSVNPVSPLFCLPDWDRLYSSNFITNWKKTILEILDKKNNYIFFILPEFISFEFRLKEELDSIRLKNGDYFKAILNLKLLLNNPIIDQIEQRYKNKECENEDKFNHHEERQWYLKKKQHLKKCFMKVIKIFVLSIEHNLIYSLMYTLEKTIYYGFVGNRLGDNSLFYYHKLNILNDVIFLMNENLIKSIFLNLDAMMICILHKLPSVAKKKRYTDNFFQNFDETVKRSILHLYIRLSEYIIKIGTIKKICGGKYEFIVFQFEAIKIFLEGSEETCILNSKKSGYEKEFKIDELLQFSACCLQQILGLSFHRTCFHNLRNWFKGFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU42</accession>
    <name>A0A4Q9LU42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0872p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000872">
        <property type="protein sequence ID" value="TBU12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU42"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0872p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020717161" evidence="1">
        <location>
            <begin position="18"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="615" mass="72572" checksum="FF6DF589FFB8D289" modified="2019-07-31" version="1">MIRSFPIFLYFWQIFLAADKNGVKILSYDEIRNEMYNNPLVYCVSIMCLNTFRKQNLLSKIIEEDLELPYPSIYDKIMSDTVFIKYNIKYLLKYEKDILKLFKFLKPKEATVWFVMFRSRLLNIIFCFFKDYLKDYSDKFNNHPFFRNMLKRQVSKNLDLNLANFDKFLEEKREIEIKMLQFDLNAYFERENVNYYLDKSLIGSENDINKVVDLEVDRENFDLTENPTNSGNKSVKDIHLIAGKKTENSKPKAQYPSPISDSKAISDSKEMNKVEYKSDVRIAKSIVASDNLPKIQSEKYKGTYKKDTKDRLKLYLQIFFENLLSNPHNPSRETEFSCYKQSNLYKRHKEMCENGTLESSDFIFSFFYKILFLKFETQWKDLLSLISTESNAGIQNILAYLDDYIPSSDFQMGVSNETLFISIQESTIPKMYLDEIVLVFDIDDTLFPTTSYGDKYPDLGTPEFYESQNNIFADPKEENPKKGINDQEIKTKLLVTQHLEYKTELKIFLEKLPFKKICFTNAEKIHAEWALKTLDILDCFICIVHREKLHEYIFLKPNPHAYFAIEQLLETKASNIYFYDDIDQNVQAAKNRGWNSFLVRDSLIDVLETSLSNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU75</accession>
    <name>A0A4Q9LU75_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">CWI38_0901p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000901">
        <property type="protein sequence ID" value="TBU12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU75"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0901p0020"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="35899" checksum="2FABD90667FA08F3" modified="2019-07-31" version="1">MSEIYKARDILNGNKYNITQKMRALFYLRNINTIESVLIIISAFHNESVLLKHELAYVLGQMRNPSCIDTLKNVLRNTEENEIVRHECAEALGNFLDKKNIEFLKSFYEDASIPVRETCYLAVRKIENHHQLNNKIEVETNENSINEYSVDDFVKFDKIEISEFDSYDPAYPLIIDDYILESIYLYHRDIYFRYGAMFSLRNKKNVDVLVKGFIDPSALFRHEVAFVLGQLRMKESIPHLKAVLADENEHDMVRHECAETLGAIGTDECYEILKKYLQCDADIVRESAEVALDICVYEMSNDAEYCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD6</accession>
    <name>A0A4Q9LUD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0871p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000871">
        <property type="protein sequence ID" value="TBU12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0871p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="292"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1440" mass="166209" checksum="7CB348F2446B09A0" modified="2019-07-31" version="1">MCDVDVAMLYERLQPPPTFHDTTHQPPSSSCQTSPVCLVDTILSSSGYDASACEPANGMTNLNTDSILEGNRLMVLHSILDSVTVVEQEWPRSAILAVQKRFKRRPRNGWPATLRYYNEKFGCTLDIEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVMVRTQKLPSELVDSKILDLINRIIGEYADSYVPMTITAVAQIIKAAQVFYDEATRKEKLRSAWKENIESKISKLVLSKDLLEKARKHEKLSPSETKSLKQIMREFNLNLSSVTDLSEALVKKNETLNVYEKKITMYESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVRFWSTMWNKNDDTVTYDDFLIPFKFTTLHKYLYDIVKVICSEGTPKADWFYCGLTYLIHKRIPQRGSDYRPINCMSYLYKFTTKCVTKVVQLKMEKRGLLAENHLEAQALVNIALNKDKKIERGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTYHLLFIDDLKLLAKDSSTLRAMTDEAKEFLEVIGLEINKEKLATNDTCCEDTSTLLEGVSVYKYLGIVEDSRGIPTLSSFEEVQSKLISRVELICHTRLNATNLFSAINQHAISLINYHKGVLRIEPADFSKLNDAVRVVLVKNKIHLRPGCKERLYLPRAELGRGLHSVELRSEHMLLQFLDRLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSRGNIRPRNEAVFCYIQDRNVFLGADGMCQHCGKSGKTIDHLATRCEKTLGHDYTRQHNEVIRFLHLFLLNRYKFKSPKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQTVETEKLRKYDLLANNLGLIFKCSVEIIPYVMTWDGIAYIQSIVLKKTVETISFDRRRGLESGINAEESWKRASMGVIMRSEMHEEPTPLLKEEKREEDGAKKFKPNNKAPFISQGGTTLEEPTNNINKESVKLPLKLDTPSLNIDLDQMLIDKVSFLKIIEEFDQAIISNKKENLKSKNIMEKYSYNIANPNEKYLYTDLKHKIIVPDDISVRLINQIHLILGHCGINRLYYSIKNLKLISNIKAKIKHIVSTCSTCMINKIQTISYEKITGFFENAQPLEKICSEILGPLINQFYKRKFYILRITDEIIFNQSRLDLLERTREINLESIATRIKQAADSENRKSNAKRKTEFVYEVGNFVLVKNHNRSKLDPFYIGPAKVVTMHRNNNVNNFCNGSSKKSDKKAIIDFILNEENSHKTEFYVLKDSPIKILLGNEFLINNKAVLDFKDKKLTIYGVKYNLVGSEKDTEELMDKRLIDNICATTNDEELKMFLKSIILTKINANQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH6</accession>
    <name>A0A4Q9LUH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1313p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001313">
        <property type="protein sequence ID" value="TBU11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1313p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="270" mass="30882" checksum="A768206B177B9146" modified="2019-07-31" version="1" fragment="single">RNNESLRGVNHISNDYKGVNDRDIFIRNNSTLRGVNNLSNDYKGVNDRDIFCRNNSTLRSVNHISNNNTVNLPFIGIYTYKLHNTAVLGINIYKNMIVTCSDDHTIAITYSKGNSNEDYCSNKGISNRDINNSNINNKDINTKDINKDITDNINTKDTNNTIDSKDISNINVLDETDKIISYNLKYIAHSGRVLCVYTVDKYILSVGSDRYVRVWRIEDLSFVKQIKWYSDSVCRMYGYKESECGEEVIKVILFGTGIENIDINIIDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI8</accession>
    <name>A0A4Q9LUI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0805p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000805">
        <property type="protein sequence ID" value="TBU12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0805p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="21915" checksum="0BA864965D9B87CB" modified="2019-07-31" version="1" fragment="single">MKGVKGVSDCRGGSGISTDVLEGVSNGTDVLGSFYNLSNINVINILSMGRKKNVSSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMTLRTIFDSVTADPKEWLRIVFFAVQTRFERMPRNGWTELHRYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP9</accession>
    <name>A0A4Q9LUP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1693p0020</name>
        <name evidence="2" type="ORF">CWI38_1273p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001693">
        <property type="protein sequence ID" value="TBT98573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001273">
        <property type="protein sequence ID" value="TBU11310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1693p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1273p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="183" mass="21882" checksum="F7D285350182F398" modified="2019-07-31" version="1">MLIFTYTNSTKFKILDNLVYENNIFINCPIKLKYPTIHFIDKDSKNVKECDFLCIFSENMLYENFKNLIINYSGVVITRDKNNFESFFDVILDTKDYREYDDTFIKYEYKNTSFICKFGLNDVKESYNGKKEDNSFVGKAIEDNIEVDHNRRKNGFLDTKFQELKMEKDNDSLKNILKRFSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT3</accession>
    <name>A0A4Q9LUT3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0941p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000941">
        <property type="protein sequence ID" value="TBU12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0941p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="86870" checksum="C139CE880A041D98" modified="2019-07-31" version="1">MEKNEKNEEEEADGEFEEDYEIKILHGYENNYYDISKPFFIYSKENLVNFEVLDSILSLNMSENKPKEGIIECRYQLSYFLRLTRDVTEVTNNLNIQQFKYILMTLKFLKAVENKNITKLLQVLIFNNFFYQKDYKLRNYNLHLIQILNSSFFTQIDFHLKRNIMSSFLNSLMIRYDFYDENLIIFKNSKELFDYSMFSEHIPYKNLMINNFDAFCSVENILRDSNVLIIFQILLKEINIKSLILNNFFRHLNPDENFAFLISKIEIFKAFTISNYKIPASPFFLFCLIVSINNNIEYLRLENISYCRLNLRGLLEGKKLKGLILSKIGLTENASLINESRNVSETIEYIDIQGVFLNHSIWHEIFQSTNSSKIILHFNNSDIEEIFINNLKKFEIQKNSVLYLEIKFNSSTLPRGFCNSLIHFKNLKTLKLDGYIIYEDTESLLYKAIYYMKELECLVLCQNCRNTKPYIFLLQNSKIDCLDIQSTSNNNDAIMIEFFRLHKSMTRISIKDAKVSSLCLKEIFKQKNLIHLCLDIDILPPQVDQESLTFKSKNIHNLDLCNNTLKYIEGVDILSKLYRVHTLRISKCNPPPGYLSKLNKKCNSYVKILTYEYGILDFDDLNRIGKLGNLLKLNLLGCKFSGCSFFDLVTSCKFFKSLKTINLLNSNIKMKDFQCMKRFKKLKRAVFSFTEFNLLTLKNSLASLQICKLKFHTMLEDSNYNEFCLYLNESNIYILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV01</accession>
    <name>A0A4Q9LV01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1122p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001122">
        <property type="protein sequence ID" value="TBU11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1122p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="111" mass="13454" checksum="EFB874952376E715" modified="2019-07-31" version="1">MITMCESIFTFSFFGKKKENIQNSEKNKTSEKKDANKSGKKEEKSKSWFEKMKERRNSEKNKKKLKKEEKKQKKEEMKKQKDEIKENPKIYRPNKKDDIDIIKDDKKAKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV18</accession>
    <name>A0A4Q9LV18_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative class 3 lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0723p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000723">
        <property type="protein sequence ID" value="TBU12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0723p0010"/>
    <dbReference type="OrthoDB" id="2191741at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="17103" checksum="8210FCD0FA527D58" modified="2019-07-31" version="1" fragment="single">YGDDIVSRISYGSFLDLKYLTCSVGSKGYFLFNKNVSEYIKMIKEYLKISNLHQKLYLPGNIFHFRKFNVPKSKFFLFGLFKPSNIKEPIFIKKVDKSFSEEIIISRFCFLHHFFTYLLQSFDYFLENEGDGNLCMAYKDIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV26</accession>
    <name>A0A4Q9LV26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mad3/BUB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1200p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001200">
        <property type="protein sequence ID" value="TBU11450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1200p0020"/>
    <dbReference type="OrthoDB" id="2192347at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031522">
        <property type="entry name" value="Mad3_Bub1_I_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17014">
        <property type="entry name" value="Mad3_BUB1_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="52041" checksum="771AC0EA17ACB6A1" modified="2019-07-31" version="1">MMHFGISKDYHWIYIELANHFKKLKYFELSYYVLSEAKRKNVFDAFEIEKEINNYSFDTKRFSDTEMKRILYPKRIYFWDTEWSINEILYCNLDNCFYKKNGEISFVSFEENRYLNGWWQKSENDLNFLEIKKFESEIENSYKYEEKDEKNFNKLRIETTDFENTKEELILKSKAVENQSNKNNSGVEQLNDSGKINKFLSEDEININNLIFQIKKRINNQKFIIFCLTENNNLEQSTEIKNYILEEIDEKYLKNIFKFTNNIFPTDLQSIVIAEKYFIKYPFSYETSVSEILNCYQEKKNVNEYIIGFYWIKILKLLIELKEQNLAIKELSLSDIMIENDLFSFKICNFKVENTCFENKNDLYENYKFFEDLNSFGDLKIFQFLNEYKNYDYLEFSIKIENILNNCDIKDILNEQLIFFYESKNNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV47</accession>
    <name>A0A4Q9LV47_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1190p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001190">
        <property type="protein sequence ID" value="TBU11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1190p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="112321" checksum="30B0819780E6FDE1" modified="2019-07-31" version="1">MYNKKLFFLSNVFLNTKKITLKTHRKHILLILVPLFFVSSFLRTTNCVKITIYFGPIDNPENPISIQTETYSFLNPYNQKINHNNEPSQHSNNPDMNQCLESVTQEEYNRSIKNYRLETNNEKYMSHTYNVFPNLSPNTMYYDANIAQDDLNMSDFNEEGCYNISSDNEKIITPEIIYFDSLNESNPEETYVNIKDITESNIDHILCEICLNILYFGWNIDFPGLRNEQFLDFIWFFYDLSVYSESDELDTFYKNLLPFLFSYMADKSCFNVFDAQESEFSKYRNFFLPFLVVLYDSLNIYFNSNTKELCLIEKKLSKKCDLVGLNSSEQITIRTTPFALIQIKDDNTIIKKTLFLKLLNFHFIYEIRISNDDRYYSEYKDSDSAYDFLKNNSSASNDETYFFSVFNLEKIIKNVNIKFIEFERVNLSSKDLPFLQNFRKLESLILVKCSFDNYLGFLNELYFYFPNLEILRIINAKLRKSCLYVNSFSKFRIKQLETLKKFKIDYSCLDYILLEALINHDNLEVLSMRGVVFFSIENFFRACSKLIRILNQPSLNFNTKKLSLSGNEFRLELIHSLKNFEFLECLNLSNLKTDLMKDFDCDCRFKHNLLSNSIIGYLSQFSRLEYLNLSDCDLDTGFVELLCTTSFQKSLKKPEFARNKLNKFDIYKIYLLTNIRYITVSFDAEVFSDFLKTYGFLEFLNLETIIFVATNFVSDICNFVMIQPSLKNLELLECEIEGGLNSSKYGVQNNYENHTSEVPYFSHNARLSNTRAIRKASNFILCSTARYYNEKFGCTETLEVLKKLAKSEMGKVLKSEENRERRRIATSVKVCYDEATRKEKPRSAWKENIESKISKLDLSKDLLEKACKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDETVSFWSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV57</accession>
    <name>A0A4Q9LV57_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0711p0040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="PITK01000711">
        <property type="protein sequence ID" value="TBU12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV57"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0711p0040"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23276">
        <property type="entry name" value="beta-trefoil_MIR_PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="755" mass="88087" checksum="1421A4F4463464A1" modified="2019-07-31" version="1">MNRQFYTSTILFLLDFTIKTFKIENGNFVIWDEAHFGKFAQRYANREFYFDVHPPLGKMMTAVSNVLFNMDREFKFESSEEYPTGTDYPSMRRFHAFISSFIPLLAYLTLINLQFTHFTSLITALLLVFENGMVSISRLILLDSHLLFFTALTTYFLTRYLSRKYLIKDQIINKNLKNICEIIETKPYIEQENEIKSNSSKNLSKNVKTGSNIDKEPKPDPSAIQDKPSNNQTYLNYNPIPTLLFLGLSIGCVLGVKWIGCLTTLYSGLPIIFILYKKLINKDYSLLNFTKKLTALSILLILTPISIYILFFILHFRILIYSGSDDSHMSSLFQSRLVNSEIGTVNKYINYGTVVTLKSSKNAGGNLHSHQHSYPDTPGNHYQITTYHHSDTNNNWAFQKVTDTPTNPRFLGHNDKIVLYHTETQQYLSVLQNRVTSSPLTTASIWTLEIVTDILGKEHNVKTLTTRFRLKNVESGCYLSSSNNNYPSWGYNQGEVVCTKKKDVTTLWNIESNPYKSNKEEHNKESNQESMQEHIKEGNDENLQLVNPEYREVRNLQTFFISHFLHLNTSMFLTNKSFTQEKDLEPVRLVSKPIEWFILRRGLRMTGWSTERPKFYMFGNPISWYLSNICVLIGPLILLIKTIKIKRNLKNRLDPTIRHNIARDYLCIYLFTGGWLLHYIPFFFVGRVLYFHHYFPALFFSILSTSYVLQHTRKISIFILFICILTFFLFSPLTYGIVNIENMKYFKWISTWDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV84</accession>
    <name>A0A4Q9LV84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1172p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001172">
        <property type="protein sequence ID" value="TBU11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1172p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="48547" checksum="E024FC71992F8350" modified="2019-07-31" version="1">MHEVFTNTISSAIIYGKNSSLFFMVVLLIVGLKVESRMVFHLYDENECKTTDIDCYKREDIEYSGFIKKKFNCYQHKNCFGCKKIIIEKSKDFPLKFKSVAGEETDVHAFIRREVVTYDDFSYFIRILMNTSELNESLRIEKFLMVVNILDIFEFEKNKNYGRFIRRILLPTIFSNQINDTKDGSCVQKDVSISFLKILFCEFIKIYIFDKKFFDQKISEDEITNILKHSFDINSMIKIKFIYFSSDLLAKIDRCLIFNPEFKYSLKTIFQKVRIQKIFVKSHDSLNHVSYDTQYLLFSNAQVLYFHSWLDMNFFESLARNFILQNIDSIYFIYCNFLSFSESFFNNLAALKNIYLIDSYSYTIENLDKIYPYIQNMISPLYFEIKSKKNIDNFVTINTNEPYIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE3</accession>
    <name>A0A4Q9LVE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0794p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000794">
        <property type="protein sequence ID" value="TBU12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0794p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="25230" checksum="E6A2DD20D39BA45B" modified="2019-07-31" version="1">MIFFHLFEDNITDHIEEEYFLYVLFLFEVLLIKVDNLKTKIKKFRDLSNDNLLEALEILPLKIILIQICLGFKNGIAMSKRFITVYLLEFTYLFMAGRKVILGFDDEFYRIIILPLYHYIYDDSLSLCGELYSRIGNVLALLSKKDLKNLYSEFTISDIDYPECLRDIRDFLQRIASSILNFESLDHQEISSNINSCIFYIYLLGLNIYKNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF8</accession>
    <name>A0A4Q9LVF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0670p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000670">
        <property type="protein sequence ID" value="TBU12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0670p0030"/>
    <dbReference type="OrthoDB" id="2196169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="300" mass="36330" checksum="CC1C921D7217A40A" modified="2019-07-31" version="1">MYLFVDKGVYIIPYNSVEIDGKVIKDKYKESYNENYRDYSKECIVKNKNCMNYILKFTDGRFTLSYFKILICNNLYEKIFIEVSNFTYFCEVFYEFRYFNFIYKYFNETDKEFGKEAGKKIGEGRNIVYLETDNRTKEEKEYNNIFSVSTKKRMEKYKEMEIKINKKLNKMNKENFKKEVKLNKKINKEGKTDYKVIKEINDLNDKKLGIEISFYPKIYDSIHTSLNNSEFYFSKNISTQIYKLLSTNKMKLEDLKKYICKENCKENCKENGEEAFLKHINSLIFYGIVVYKNEFLYIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY0</accession>
    <name>A0A4Q9LVY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0963p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000963">
        <property type="protein sequence ID" value="TBU11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0963p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020448656" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="27050" checksum="969FA584B964CDB2" modified="2019-07-31" version="1">MKNTTGLFILFAIINTLYALKTTKQKLLGADDKKLVSKSPLAKSEAIQSLDGPEDEEGHPEHKAAMSYSIFKSNKPRDDNEENTKNSLKTNKKQKVTPPLVRNPDDLSHKLSSKKKKEEVSKTLPDTHKEPEENPTQQKGFSTPDMMAISQTYQPPVATAMNKKEESTNPPNNPNPVTKVLENQGIVKNMMNELANIISANDKILTDMLQAQGDNSTFKDSSLKPSERLDYKIIEVEEDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE5</accession>
    <name>A0A4Q9LWE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0668p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000668">
        <property type="protein sequence ID" value="TBU12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0668p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12238" checksum="0E4EC50F78C4D086" modified="2019-07-31" version="1" fragment="single">MYFIDLLTASSTFAEQHNASLNIMRAEESTPINYSRPIPRKPKKKICENFLLERKSRIMNSSVKRKLDFDLNISQNIADSSYIDERTPKENINLENNSKKKSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL0</accession>
    <name>A0A4Q9LWL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0845p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000845">
        <property type="protein sequence ID" value="TBU12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0845p0020"/>
    <dbReference type="OrthoDB" id="2190781at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="17306" checksum="121347FB7A68AB16" modified="2019-07-31" version="1">MNLLNEKRDRLVKRVEETIKTTNQLLSSINYNIEEIVEQNVILVDLSESYKNWYFKLNNYKLEISMNLETYIQSIVLKKTVETISFDQRRGLSSMDVIMRADMHEESKHPLKQANREEKDNKYFKTRNNTLAISNGGTQPEEPRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ4</accession>
    <name>A0A4Q9LWQ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0531p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000531">
        <property type="protein sequence ID" value="TBU13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0531p0040"/>
    <dbReference type="OrthoDB" id="1693703at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="31330" checksum="EF8E4FF0482CB5D1" modified="2019-07-31" version="1" fragment="single">MENVEENLLNSEKRDSKYKQLTKEQRQGILEKLLQQMKENRLKYAEFSMQHKLNTEKARYVPMFLQKRKKSLFFAIDIQKSTLFDIFKISSTVKPTLTDKNKMDRLKFCLSKVNLANNGDLLFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEENPERNCKSKRFITKIMFMAAVARPRYDAHRKLYFDGKIGIWPFVYQEPARRNSKNRAKGTMITKNVESVAAVHCKNMIIDNVIPAIKSKFPPADKKKILYVQQDNAKPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS4</accession>
    <name>A0A4Q9LWS4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0894p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000894">
        <property type="protein sequence ID" value="TBU12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0894p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="402" mass="47951" checksum="7B8B4CA2E694F720" modified="2019-07-31" version="1">MVYGKTDLVRIFCCLKFIVCYLTLEDLPSQYLNIKHGNFSRRYILETELGKGTYGTVFLASSESTSKNFAIKVQRIDFYNIFKYSSDIQFTTILRHENIVEIFEFKIIQDLEYAIYEYIPLTFCDFFRTHIVEFKAFLYFIKQILDALNYLRIKKIVYLDLKDNNIMITKDFTCKIIDFGIATFEESQNNIFRNSYTSIDDVNDTKYSFYAPEIRTCKKFNHKADIWSLGQIFEEYFEGYKETIKSKEYKLIVADFISKTLDPSPKNRISADKALLHPIFNILYDFVFCFAMLPDFFHYKNDISLLKNGKRVFFKNKRQCFEIHCCCINKTDCFQSGYNLTHKFKFSNRIFQIFSKKKIPNADPLKFKVLLNEQILPIQHLTHRQYKKLKLIFKILRNKLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY9</accession>
    <name>A0A4Q9LWY9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0789p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000789">
        <property type="protein sequence ID" value="TBU12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LWY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0789p0010"/>
    <dbReference type="OrthoDB" id="2375545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1351" mass="156155" checksum="F10BDE902070C849" modified="2019-07-31" version="1">MDAKERFKKLNKENLRVNFDIFQEIELLKKYNFQNSNKANFEKITRILSPFRKKQEISEILNLFQFIVTDATGIGKFSKHMVVRLYKDGKEYVFKNVGETVELIEYFVQWPGELGEGVTFATNIQPIKKVETQSEGTTNSYFVKILEGFEFKWKKLYRASERELTKGVLVLYIDIEPLNLCPYNNCTSVPIYDSVEESLKARVGSPERLRELLGTLELSDGSYHTLNAQSYSVVSSDKAFSVEFKKEKQITSCQSELRKFTKNFIEVNIYPNLTINKTTIHNYLIQRNTTPIAGLEDFWNANSYEGLVYDHGYFLQSKLQADLDIETSFVRVFMESPTPVLFARFLTIVFGGRGIVYGDSLYLANRYNVYEEYNKEATLGMLAYFGEQLLRGLDAPNGLYNKYLAMRFNLQSPGFLKSCISVLFPFLRDEAKGLGFNTNFAILPLKDGAFDAELNKVRKLELSDYISITLPFSEKDLVYSDNTVIAMSFLENLFKSQEEVEYVLNELRIILFNKMNDKIYFLIGDRANGKTTFINILRNSLKNLVDYLPVEAISNNRDSGGVGGANTTANNLPKFSATVDYALERRMRYVYFSKNFSNPANILNLLDLNSNNVVNCISLGLLQLILNSRINEQITMPKTFVSYDSICSIKNLLILKYRSISNSKNSAMNPFIVNLRNCRIGVVAEFGAHLLQVDMIKRLAGCETITVRSLYSNPVTFRFKTRLFFVANNLPKFASTVDYALERRIKYIYFAKNLSIKANVKNEIDLSKATIYNAIGLGLLQLILKDPLDKDPKMPVTFQRYASYAFGELRAFAKFLEIVIKEDTEGYITFFQVYCLFNELDGTHTPKEFSGKQEYSAKYNEFKAFVKAKFNVEECLTRLKLHNNNKDDDNNESNNESITPLSKSGLPVTDFILKSNKIFNYNEKLTFQEIAEYGIPIIDYYLYMKFRRDDIKIIIDPNLPSYKESDISRMINIEIERFSKSDQQRLHSGIAGSRLFNIFRSNIPKNLNTCSEDLINIYNVINEVADNGPFYEMHPFFMPIELANISLCKNLYNLIVKLYSKEKIEYFKKCKQLYEIKGYDARYSQYLKWDKDTFNKFNLNFDSLKKKIIRKIKNIKKELLMEWIEHFEYMNKQMGLIAYKLIDDEDYNESLTKTYLETLETVLLCQLNRRKTSTNTIESTSLKTEINYRDGKWFLKQYSKSDMNIELPTMINGRKTNVMINSGSNRNYVYHSMIKKFDLKTEECKPIRTIFGSGSSQIGDKKAIINLVLNEKNSYKLNSILIDNICAIANDEELINIPKKSIGNKINTDNFSKNNSLLYNNRGMVSRNTISLLEKYFKLSCLPEITASLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY25</accession>
    <name>A0A4Q9LY25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0685p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000685">
        <property type="protein sequence ID" value="TBU12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0685p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020316512" evidence="2">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="585" mass="68839" checksum="E14BB8BB59D966F3" modified="2019-07-31" version="1">MSFLVILQLITNFGISATAPQTPPVAQPQLNQEKVCSLVATFEQQDPLTNRNFQLLYLPTIDYNLNCDISIIISEMFPNTDFDAVFNKKIEPLVRFYFSYAMKVTEQYCHEFLKRFIAFVCYLTYFDEFPKKIDQPHIEFCPNIELLYNIVAFAAAYNLSKSNKEFEEKFNEFEINTIISFDNSFRLGRDYEPERNEEETEDFLRSRSISIGINDINADIVNQKDVECFSKEKTVFYDINTNKWAHFILTSSFERLFSMFITLKHIEFNRPEYSDDYGYLGKKCKPIFLGLFVFLEKTAIWMPDFSFLTLEIDEVKAFYNKFLNLYDPTANRGDLTVDVFIDGVLDKSMEKNTNDEFFSQRLIKQCYGDLSADDLEKMRNFFNILCGINNKYEISVISALLSLKTSSIVTSDLYEKIIRMVFEMLFYIKTYSEVQMKSYFEPKIKRCVHFVKKELIAKGYKFDNIEDLADMNREYISDTELEVICRAAVYSNGFLFCKNSFAIETIQLLPKLAYTESWLNEAILRFITTGESSEYPIHEPIMDKNTVKKQNQTNWFRIGVFTVLLGYTISLVIYLYFVIRYFYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY47</accession>
    <name>A0A4Q9LY47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0416p0020</name>
        <name evidence="8" type="ORF">CWI38_0345p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000416">
        <property type="protein sequence ID" value="TBU02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000345">
        <property type="protein sequence ID" value="TBU13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY47"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0416p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0345p0020"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="159" mass="18741" checksum="4D9FD80AA5C32B90" modified="2019-07-31" version="1">MQDLAQKIATKMNCIKYDYIGVNNRLYEKIYKYMRRPVVNESLISPKISNQTIMLLNSRLRSMRENAVDVLGIYLKSFLESEEKNYSQGSSSPQKPRRFPKNIVEALEDSFNEDQYPTDSEKSRLAKVFHLTTKQVNNWFTNKRNRTKYAGDSQKHNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY99</accession>
    <name>A0A4Q9LY99_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0326p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000326">
        <property type="protein sequence ID" value="TBU14425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY99"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0326p0020"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU14425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="555" mass="62115" checksum="5E71D074CE80701E" modified="2019-07-31" version="1">MPQKNFGSIYSTSSKKKKTKTVPSEVEKMSKTNANDINNSVLPQSTGKKENDTKDSKININIKNISKTHPENKNNLLNNNKDPKSTTILETEESKNDQAKQKETEELKRDINQKVKENSKHFTGILKSNNINVTNLVTEDDFSPVANRCCENIIGYKKIPMGISKYSFQINGRGFWVPLCTTEGALVASMCRGIKLLNRGYLEGVVENIGITRSFSVEFYKFKDAVNFYKELKKDVYHILDEEIKDEVSPEKAKAILKEGGEYYHVRDVLIESMIKECDPSSAEQKKEEPKENISLVDRLTKIGNSTSNYLKVKSISTKHIINNTVFIKVHAYSGEAMGMNMITKACKAMIDYLRTNYNIKTSCLSANICTDKKWSIENYCNGRGRRVFMNIFISEEDCLEVLKVTCADLYKTYYSKICLGSALVLGNFNCQAANYIAALFIALGQDCGQIIESSNCLLSMEKVDLGLNISLLMPSIVVGVLGGGTHLEPSKEFLKQFYINESKNVITDKRYDSSYAPSYLALLVAGVVLAGELSALGALTNDTLMDAHLKLNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA4</accession>
    <name>A0A4Q9LYA4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0591p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000591">
        <property type="protein sequence ID" value="TBU12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0591p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="24003" checksum="F0073B681EEC2171" modified="2019-07-31" version="1">MYIPNSNHWMINLNNNIYLKSIHIELEAFDKLPVIRNACNAKLHYIKLANCNLPGKSIILSFSSPYMLKNIKIFNYFGNFLSKNDLFYLSFMTKCKSLELSFCKLENCTLYDMFAADKLYIIEELYILDIILGKYDFLAIQKLKYLKYIGISLFRDSLSFIYYFKRMYFKRLRSFGTLKPAISLQERNYLISEFGSALDIYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ6</accession>
    <name>A0A4Q9LYQ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Activator of Hsp90 ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0601p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000601">
        <property type="protein sequence ID" value="TBU12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0601p0030"/>
    <dbReference type="OrthoDB" id="2195936at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31533" checksum="6C2259F39F5D9EDB" modified="2019-07-31" version="1">MSSLNPNNYHWTECNITGWSHDFLKRELQNMGYTTSKIEGDVHISQRMNKIGLLYTLNLTASKNGDSIILKDFDIYSDIEDILCRNDTDKQIFHKILVQMRNEAISNFSEQVILDKKCDTEVKKNAVNKLPVSKNEDTVNTNVSVEKISGYSISLLFNVSSDDLFNFFTKKEFINIWTNGEAVYGENQRFLYNLIIEKNINISDKFIKMDWKLKKWEMLSRVEISFVSQDKNCMVKISHYGVPSNDVDNLKNGWMTYYFDPISRAFGFKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV4</accession>
    <name>A0A4Q9LYV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0268p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000268">
        <property type="protein sequence ID" value="TBU17676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0268p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9971" checksum="DD7E62C572179CCB" modified="2019-07-31" version="1" fragment="single">SLSEDDLRYISKLKISSLILIHTQKNLLQIYYNLIEGVIKDTLVMLKIYDETETNVAAVNLYLAKFVKLEIFIVNDQKYDLYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV5</accession>
    <name>A0A4Q9LYV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0269p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000269">
        <property type="protein sequence ID" value="TBU17671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0269p0010"/>
    <dbReference type="OrthoDB" id="2191886at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="22535" checksum="09D0A867FE9F946E" modified="2019-07-31" version="1" fragment="single">MSNLYKLTTKFVTKVVQIEVERRGLLSENQLGAVRGVQGAKEQALLNIAINKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISIGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTIKTDAESHATNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU2</accession>
    <name>A0A4Q9LZU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0198p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000198">
        <property type="protein sequence ID" value="TBU19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0198p0040"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1028" mass="122014" checksum="DB1D84D43A7C80FB" modified="2019-07-31" version="1">MVVEGNIERKSQILNMKSSVEIGLYNRHYYNTEHKNYISHLEILGPLVICIRVEKYFVRGLIKSVFGINEFKFLKSQNLYKLDEYIFGLKCCTTAFFYEIIESSNIKYEEKKEVAKSSIFGFFNVKKIFGTNKSLKFTNDTSKGNTYSDIMSVSSKFTCEISNNDIEKIRDKISLNRTSFTFDKIANKFIELDEDKKDYLKILDENIEEELIFDIILNESQNKEFIISLLGQKIDKKDFVLLKGTKRIDSLIFETSLINIKANKNEMKLKMAVKEFLEIHKNYYTLLLSSYTDVVLGFYIKNWKLDYQEKNAIFNNCFADFLKLILHESSFLEKILEKIMEILNLDMENTEKLSLNVDKNYDFLILREEKKLFEIDKNIKEIQSKIENMYFLILQSFDKKNIFLLVDCFYEVLDTELRNVESVYVNFSKEYDIFMNNITTNLKFYNFENIGNIKFTFYEIIKRMTVINSFLCKISEYYGDSLEENFRRMKIINTKYKIITQRINDERDIICMHKRIFEIQHKIINTPGSLINNERRFIKVINCKVYNNIIDYTLFLFNDVIVFTKRIGDEISNLDLDLKNCNLFFIKMVNLKDIRIKNYRKGFFKIIVSELVTDEKHKSMPGFVHTKDLHYNIESCIFVCNDQDIKKQFVQKVYICQNDLRVMTSSADLYLSYSDPPIFYFVYDFEKNPKNLECGKYLMIFSDKSTEDSVKNHRWMDYLLDSDRSKKIEIKFTIFLGKKVKIKIDNFINNEFKEIIMKKENFEQNFSVYFKNFLSTVNPSSQNKNETSFSLINDLKVLYDLSLKDKKNKIPLKKNVGKDFFITEKVELFKLLFENIEIRLKLLNSKNLISNVKKSQIKKSNNNSDEYTDTDSFRKTTIIQVLKEPNSEATVNTNDLYNINSIYILEKIQEMISTKVNFDTLNSIDIIVLTSIVSTFFKYSITQIFSYNDILELHKICKNRDTKTSEIFLNSLKGNRKDIFLMFIHHFRDVSKIISTSFFKDLIFFLFGNFIEKEEFEDNYVEILLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M007</accession>
    <name>A0A4Q9M007_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0268p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000268">
        <property type="protein sequence ID" value="TBU17674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M007"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0268p0030"/>
    <dbReference type="OrthoDB" id="10591598at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="19131" checksum="B8E36FE3ADB946F9" modified="2019-07-31" version="1">MKAEDQQKFLQLLYRFGYDMKTISGYLPEYTVEELTHIYQRLILTFGKQCVNQGGSCDIQQIKDVYFYEDEIRFDVVKEENGRLIEKGNIQLPDYKSKTYMMLKDFEFSLRWKINMVNSFYKNFEKHGNIKPYDESDVEKEGKEAEENIIENEISVNKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M065</accession>
    <name>A0A4Q9M065_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0166p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000166">
        <property type="protein sequence ID" value="TBU19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M065"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0166p0020"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="36910" checksum="ACC869A64F2BC5CC" modified="2019-07-31" version="1">MFGVIEDSRRIPTSKSFEELQTKLIARLDDAVLAVFLKNKIHICPRCKYPLYFSRKKLGRGFYSVEFKSENMLLQVLDCWEEQKDTSARRAEILKAIKLQEAQTRDDVVFCYIQDRSVLYGVEGISQHCNRSKKKMLKMLVVRCIHLLFHNKYNFESLKRIKSQSVQEIIDKEYAEIRVDTRTKTDVKIRGNRPDIIILDKRQTKISLIEIRITSQESLQIVETEKLKKYDLCANELDLIYKCNGIVTKYHKTYVKRLQIPMNMHKQPTPLLKQVDNEKDGEPKTNTNEGLELEEEQEVVEMVEKKYIKEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M075</accession>
    <name>A0A4Q9M075_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0158p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000158">
        <property type="protein sequence ID" value="TBU19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M075"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0158p0020"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20241" checksum="ED6F14154469E6A4" modified="2019-07-31" version="1">MLGRLFVNTVSLIFILYNTFNFLKLKAQKSCLIKHYHAFFITTSIFLSLDIFLNPLTKIFPLFQVVKLCFILWTSIPLCSGSLFIYKMYICKIFGKYHCKIDDFIENSRLSVVSKIVDTYQRAYSLTSDGLKNNKVINSYVFKDVKEESDTFTECVVYEEETSVIGNVKTEPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F0</accession>
    <name>A0A4Q9M0F0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase 2</fullName>
            <shortName evidence="6">MAP 2</shortName>
            <shortName evidence="6">MetAP 2</shortName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0136p0060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0F0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0060"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="46"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="39757" checksum="01A992227B324834" modified="2019-07-31" version="1">MLLINNVEPNSIEFLESEGNYKKNILFDSSNSEISNEFVNDILKDARRAAEAHRRNRQNLQQIIKPGVSLKKIVETVEDNTRILLKGEMNDGIGFPTGISLNECAAHFTLNPGDEDIFLTEKDVLKIDFGTHSNGVIMDSAFTVAFDPTYEPLLAASKEATRVGIKNMGVDVRVCDVGAAISEVIYSYEVEINNQIFPIKPVENLNGHSIEKFTIHAGISIPPVDNKDKTKVKENTFYAIETFATTGGGYVVNGKNCSHYILNPSRKIQVKNENVKTVYEIIKKKLTTLPFCPRYIDHLMPSQNSSLVPVKMLAMLKAIDSYPPLVDIKNSFVSQFEHTIFIGEHGKEILTIGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L5</accession>
    <name>A0A4Q9M0L5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0117p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000117">
        <property type="protein sequence ID" value="TBU20184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0117p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="644" mass="74867" checksum="DF2DA64FD76930E5" modified="2019-07-31" version="1" fragment="single">CFLCFNKKGKCKANYFTIIRGILIGFYIGIGGFLVYKNTLQNIFYNRKVKENPGLALTFILFSEMVNSLNNIDLNESIFLTYQNNFKVVGCVVMCVSILIGAIKHGRICGYMGIENVDVSEALFVLSLSFGVLVIDEIMKSDRKRNYSPENDDNDVPSKLCYSSEIYMNKIVEIQQENTNSEDIRDRIEKTGGLSVEESRNQKLPQSEVYSNVSNGLGILTKFFNTYGYAPEQNKNPEFEISVDSWDEKIFIDELNEMRGYVKTTNIGHPEFLDKIFNFSRKLILVERILFQSLTKSVIIKTMKKFGFEYFIIEILIDKNYVLLKDLIIFVYKYRDNFEIMLKDGLFFTVRIILNIMNDLIFSLSFFVIENLNVNFLSSILSFIKNIFDVSFGEIEKRKLHSKLYNARKNELVSVSDSSRWPRDEAVFCYIQDRNVFWGADDMYYLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYTEIRVDIRIKTDYDLLANDLGLIYKCSVEIISYMMTWDGIVTKYHKSHPKRLEIPMNVEAYIQSIVLKKTSALNAEESWERASMGTNIPLKEAKREEDGAKNFKPKNKEPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N5</accession>
    <name>A0A4Q9M0N5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subunit Sec63 of preprotein translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0215p0060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000215">
        <property type="protein sequence ID" value="TBU19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0N5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0215p0060"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="611" mass="71005" checksum="A9665D08CD694E86" modified="2019-07-31" version="1">MSHNYEYDDSGLASSYLFLSILLPITLYKIYKYFTLKSKVLEFPCVCDFCTKKVRRKRFGINSLIFLIPIVCILLKNIFTIKMERKSSIFNPYEVLGLQEEASKREIKKAFRKMNKKYDDVFAPEGSKEEYKNKKVEIGKAYNVLKDGKGFQKMIEEEIDAKGNEIVAIPKWIINQGYVMLILYAIILGLVFPRWAVSKWKKNIERNKLGVYYTTMEYLYGKISSDLVSGTSEYSTVRNLINILTETREFKERKWKTKNISEIKNLIEYKFGVPLKDDKKACDGYFILCDHLFRTGKSETQDIEYIQRTTISLLNAMKKICFARNLESVLKNIFVFEKMVVQAIFDPEYWMMQYPHVKFENILLGGKIVGKGNVYENTEEFLKSILEEADLKVDLELFKKLPKIYFKNINCGVKSTGHVEEEASDVDENSFNNENMSNMSLLESGLNSGTSSVSFDIKSDELKRKKKEIKIFKIEENALVSLNIKLDKILEDNEKIKIKSIGLGEEDPGYILQQEGEMDVKLYNSIGNYKEQACHAPFLTFRRLCRWTVYIIIDGKIYNEVSSFYDFEGEKKLLWEFDGKNAGSSSQIRICIMNDTYFGGDMCEEICLKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Y1</accession>
    <name>A0A4Q9M0Y1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0362p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000362">
        <property type="protein sequence ID" value="TBU13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Y1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0362p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="58023" checksum="0CC0288BC92E6AFD" modified="2019-07-31" version="1">MKFKNQEKNIKFFFLEIIIMLCCFAFKFGNSFSKSFILKQYVLHVACIQNCFLSASSTSSDSEASIGSDLITSSSNRSVISNSNSSEKIQIKSIHIKQLLFMITRTLVFANTQGLLIFTSDSSPEIYNLEDFSKRKNAVNPSIFENPIIFDFSIKGVFEPIDMVATIKTLAFFKVCNDKNFRLFAKSFLEFTFAKLNIYDFYSDKNEYQLENESGKRIALSFLRIYLYENNIKKIGNYELFCKSFKEYKKFKSKNFFMLADKFTRNFYFIEKHKIFFKNVFYCHKKIIHFLFLQKLVSFEKYYIDDFVLHCLYLSDMTIDFCKSTIDSIFEEFKGIKTDLENLPNKCEYKWNRHFLRSSVFVNAVAFFFYNCEIKCLNISIEDSQCFKHDVLVTLKLECVEFKIGICHFEFFIALHSLIQGKRSIKNITLNISRLQPDISIGLNQITFEKIFLPPKFEITLSIFDSPKNLSNQEYANLIKFILQPKNELVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M122</accession>
    <name>A0A4Q9M122_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0304p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000304">
        <property type="protein sequence ID" value="TBU15967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M122"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0304p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="31635" checksum="4C56BA2808E9DB72" modified="2019-07-31" version="1">MLKKERYTPEDYMYLEMKILNPIYYVSKGNTLTFTVAYVLLFFIFYTLFLLYYIGIVCFFIVKFECEEVYTVLKKYFVLVNLFTPHIVHHIMFMYKDHDITFLKLSIYNISVLICILSEICIYKNNSLNQEKILPIIIVFIYQIIRLILSFKYFGDFIFFIFKFEQQTVRNTFIFFLKFIMFFIIDAFFKPFLFNSFSEIFFLQSIFLVFKILYVAIFIRKTKYILNCIFGVIFYILLNFIFEWNILQLIFDKKKPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M199</accession>
    <name>A0A4Q9M199_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division cycle 48 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0070p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000070">
        <property type="protein sequence ID" value="TBU20439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M199"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M199"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0070p0010"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="286"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="502" mass="57166" checksum="4B80D6411ACF3609" modified="2019-07-31" version="1">MLHTKKDNNTLIRNKILSEHLKKTTIPTSHPFFCDLKSFHYLKPQVNEFLKASLMTNKSDIDVPRSLLFYGPSGVGKSYLVNSISSQYNLPIYNLNIETSKDVSDMFKKAAFCPNSLIFIDSLHLVTENRLTILQKIRENISLMNTGIVICTSHTKNEDLKNIFDYEIMVRIPTEEERREIICDLIKEIKPDLNNSLLNDIAKRTPGFVPGDLKRLFRRSIAKSIAEKTELNYEIIDLSLKEMRKETSAVTFDDVGALEEVKSELQMSIILPSQYPHKFKRLGINRPSGVLLYGPPGCGKTMLAKAVSNLSHCNFISVKGPELISKYVGDSEKEIRDLFYSAKMQSPCVIFFDEIDSLCLKRGNNEFTSRIVNQILTLMDGLEDRGEVYIIGATNRINSIDSALLRPGRFDKIIEVPMPNKEECYDIFKKCLKDVPIESFDIKDLELYGLSGAQICGVVREAAMLCLKDNFDVEDLKIGIEYFNRALSSIKRKRNLDLDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A6</accession>
    <name>A0A4Q9M1A6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0065p0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="18269" checksum="1F5834A9167A2A28" modified="2019-07-31" version="1">MAYIGVNSKNNINPSNTSVNCYVDKKCNLGHCPSDNIKTSENSLTFQRKCKNMPLKSISCFERNNSLLGPLLLINISSCKNKFGSAIRNDVQIWNNRLEIYILDRKYNEIKIHHSLQIVETEKLRKYDLLANDLEFIYKFSMEMIFHIITWDGIMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I3</accession>
    <name>A0A4Q9M1I3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0050p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0070"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="76"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42856" checksum="305F5082FD659F69" modified="2019-07-31" version="1">MESDPRKQRIITIIVIILLILYIYGFGVVTGLLILKKRFTVKETNKTCEIHQRESLAPQNFKKNESKTTLDHIDICPLINSGSLCYFNTLIQCMYSCKDLKDFFMNDSEMTEVKEILKELFERMAAKDKTINTKEFLKRIVDITSNEEFEDLNQQQDIHSLYLNLINGCFDPNFDVGNIISPDIFDDFAIHNFIFRKLYFLIEISSKESNTEQNKITYEPGNAFLLPTKKFNLYKDLKRYFEKAVFKKKNDNNEEIEVETTKELIRFPDILVLYTPYHEATLPDEIDIHRNIVFDQNIKYRLIAFGCHLGNESSGHYIAIKRMKDNTWAIINDDFITFHSWENVLKYLNYYKIKPTLSFLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N9</accession>
    <name>A0A4Q9M1N9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0283p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000283">
        <property type="protein sequence ID" value="TBU17616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0283p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="712" mass="84648" checksum="E01D3F3B9D8884E2" modified="2019-07-31" version="1">MGFNRTVNYDKKSKNEFLQYFEASNTFLYCIFTPLCFLRQINCIILEIFLLGNNIYCLNIKFIEYNGFEDYSPVSHSKSYYLCPKTSSFIRIDDSLYFQEPLETSNREKYIAISYPNDINISFKFLDEIILENKEEVSIYMKENELHMLALFIKILQECNDTITQTDSKIFFEILKYLNIFRVERNRNYKAFIRTLVYYYVISNSDFVKNSYVLILNQNEYGNLHVRDVIECFLQFILMQKAYIYDIFHKYNPIIFSHILSQHKKYKTSEKIVCIEMRACCLNKCILSRNNINIWKILMKIFLIDKLYINFCSYENDLDSDIIIALLPKIFINLKIVIDPSKLPLFGKLHQIGCFKSVKKVKISSCDIKLQSFLEKLQYFETVEKLALEFLEDNLQKSIIILEKLTILKSVKVMKLFFSISSPHLYNAFSSLLGTKDNIIIDLSNELKISDDEDDFGIFSSYNCRNYLRGIDLILYKDSYDSTYFSKIFNFELIRRLKIDLRNVKNNSLNSYRFLESFKSLKRLYFKNIKFTDELYTAILASTSLIFYQFKVFDIKKDNIGWNFYNKSVIHIEFQNLELLKCYKYQTDCKNKNLTSFSILNVVSYFFNLENLEKLNYDVGTLYTEDIVVFSRFKLLKYLSLSVQKTDLNLKILNKILQQNIKNTIIKLHIRADKLEKFEIFSILNFKQLKILKMGIILDTEINKQRLERLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M218</accession>
    <name>A0A4Q9M218_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0215p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000215">
        <property type="protein sequence ID" value="TBU19283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M218"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0215p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="41857" checksum="76CAFD2C427DE87D" modified="2019-07-31" version="1">MESSEIKKSNDTGSILKDVVMKYIDSVMFCILVILHICNNFYPSVSKTFKIQNFIGFYTTLYIITSVITRFIDISVLFYEKKESKFRRPNLIKYGVFSIATAISAFLVYYSYQIPPNTENASLKIAAISTFVFNIYDLISRSGNLTKQDCLFNLIYFLCISSAIVLNTYGKNYMTLIVLVAMICKICEIVLSRIQKKKENVLNVYFTAMSISFAVVTAGLIVYSCYKKIPYLIPVLAKAPTYVIFKKISFDRRRGIELRLNAEECWERASLCVIKRPNCINNQNTLEASKYEEYEEPKVNINNESDSKKDSDVLKKRRAKNLKQKNNTPLISQGGTTLEELTNNNNKESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M288</accession>
    <name>A0A4Q9M288_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0015p0120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M288"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M288"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0120"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="22594" checksum="84F66CD91C0150BC" modified="2019-07-31" version="1">MAKVIEENDDNNKEEEQEYVNIKVHDSERTEIEFKVRKSIPFAKILKKYCEARSKNPKVLRVAYNGIFFDLNESPESLGMKNGDEVEIMGQQTGGSDLLIQYDLLEDDLGLIYKRKILYNVEAYIQSIVLEKTVRWEGASTVVIMRAEMQEEPMLPLKEAKNMEDDEPTIKDKAESDLEKETKGVEQVEENIQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2X6</accession>
    <name>A0A4Q9M2X6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1764 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0116p0020</name>
        <name evidence="3" type="ORF">CWI38_0083p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000116">
        <property type="protein sequence ID" value="TBU04578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2X6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0116p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0050"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="121" mass="13956" checksum="5BEE192C80A68E37" modified="2019-07-31" version="1">MSEIDEIFKSVNKNKKENSKKAVNKKEFKQKTVEVENNKNKFKKPKKNESKLFNESSGITDKTQKEKKKNYKKQKDSENSNEDQNKSRFTSEGLPLLSEEALHIGKGGKSKLCPFDCDCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M314</accession>
    <name>A0A4Q9M314_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0076p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M314"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0110"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15622" checksum="F07E5429F9834F26" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRELESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINKESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M332</accession>
    <name>A0A4Q9M332_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0161p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000161">
        <property type="protein sequence ID" value="TBU19971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M332"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0161p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15184" checksum="97CEAE968DE5C753" modified="2019-07-31" version="1">MKFDTVDDDISFISHEEKNFRSLCNKSNDERALYHDSVCTNEYVRKSYNLQEKSKQKALSTIYEEKELKDKTERSENKPGMSSVSEYLNNIHDSCKDASNDRLTDILPDASIISVNDNDIDENDIPFYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H5</accession>
    <name>A0A4Q9M3H5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0128p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21872" checksum="746FBE31649A1480" modified="2019-07-31" version="1">MKLESICKEDKVTTKNITLVLEYFNENKMNQTEINNIYMFLCKEWDIKICDQKMSNLIDLLMNSGFEVIYLNEIKIFLESYNIEMFKIYGELFKNCSGCYEAFGIKSVREGFTYNANIKEVESFTPVFKKYKNKNDKRNNRTDKKNIRNASKLNAMKKAKSLRNEKIEYAEKVKEMYRKAKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4X4</accession>
    <name>A0A4Q9M4X4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4X4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19868" checksum="1BB4152E1788C4E8" modified="2019-07-31" version="1">MLNSSANEEKCQLEKINKNTNNDTSEFLLEELLDYLFETYYIYIKSIIQIQSIEIDGSNDKASEIMSIMSCNAHQKLVIFRKIASLNLALTYYYDFNKNHNTESLFSSVDDIPLAFFERETVLNELMLKICRKATEESKYNLIDIFNSFIVTNFKNMQSDYSKIKNLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M556</accession>
    <name>A0A4Q9M556_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0031p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M556"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="31188" checksum="CEA57DA5139041F0" modified="2019-07-31" version="1">MSSYDVLKKDICLDVLPEDIIIGTKREKKMNKCIFFWILSFTQIIFIGAFILFLSYIYKYDIAIEMSIKYFVYITIINSYFYIKNIKEDIVAITLIRYTFMAIINFFVIFFDYKLSFLINTGSNLYPEKHFTSTKVSIFLMFFLWLSLCNVYFYSKEIKKYINIRKTSTFIFCVLYTLETFIMLEMKVLDVLGLIDRSNTYHIVSFLIIILSKLVFIMFDVIDNCKLKSIIVPVIFICLYFWDIYKMAFLEWKSWINSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX19</accession>
    <name>A0A4V2JX19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2070p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002070">
        <property type="protein sequence ID" value="TBU10032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2070p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="19052" checksum="1BB04718FDA60594" modified="2019-07-31" version="1" fragment="single">KNSSVKFQSHFEENFKKNDDFLDSEKSNSKNKETSSVNKNSINFNSYNNSELRSNESFIENANSNDFDSNRNSEFRKKEIVFEHTNPNNFNTKNNFDDKNNFDDKNNFKDERFPCGSCKRRIIEIEELRNFMFQMKIEMRREIFALRKEIEKLKKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX57</accession>
    <name>A0A4V2JX57_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1691p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001691">
        <property type="protein sequence ID" value="TBU10542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX57"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1691p0020"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="25411" checksum="49182AE39DEED6F8" modified="2019-07-31" version="1" fragment="single">ILDNNQDNKDILDNKNILDNQDNKDILDNKDNNKNILDNNKDISDNKNHTTNNNNNNNVTVSLIYDGSHNSCRVEEYIINGINKEVLVYRKGVSYGLEVGNKKLCEEYKNIGQPIMVGGSMGTYSYIVCIGNKGVFNSCCHGSGRLLSRKEGLKRYEGEGVVKEMERKNIVLRCSSVKGVGEEADGCYKDVVGVVEYSDRMGLTRRLCRLKPLIVIKGIVSNKDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH2</accession>
    <name>A0A4V2JXH2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1033p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001033">
        <property type="protein sequence ID" value="TBU11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1033p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="264" mass="30330" checksum="26EF578396C583B0" modified="2019-07-31" version="1">MSNSFSGKNTGENKYHFHVGQTLEYIECENDNGSVCFVETSGSRNENLSLTTILTPRKQIVCNNDLKRTIVKTMKGHLMSAIASMYRINYQTVNSILTLEIKECLETYVDLEGIKTLITFNVNAPHIPLHSKAVTLVPEPQDQLRNCFRELVVNYDDKNFVFLNKVGRAVETRPSRGCNKRGESACLSYFSGRSNEQICMIYHKTYERIVNEKNLKLSNKEIYESCKQQKILTSIFVMNNARISHNRGLNEDEEIACNSWWCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ3</accession>
    <name>A0A4V2JXJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0929p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000929">
        <property type="protein sequence ID" value="TBU12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0929p0020"/>
    <dbReference type="OrthoDB" id="2186267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="350" mass="40507" checksum="E006725DA1DA0B46" modified="2019-07-31" version="1" fragment="single">YKKKTIYVQQNNANPHFSDNDADIVALGSADDRNIKFKVQLANSPNLNVLGLGFFNSIQSLQHQASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHLSKGKLRREGRLLEKYVGSKEAYEVQNNKVLFYRSFLCNLTPFNPTIVYNAYNIFYKTTSLTYFLVNNNPLFSIYEYETPFNNTPNKIMELIQLQDNLKVFEDYPPQNNLTTLSERLKNITSLSILKKELDGHFKEIMDKNDDSIYYYESIRMLKFIDKLFKKIEEHTSQLNGDGVDDMIDVYVESLVNYVDNVDVIKEHIEIKMYSGVRYCVQALQKSGKTMNHLENEYEKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ1</accession>
    <name>A0A4V2JXQ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI37_0030p0070</name>
        <name evidence="18" type="ORF">CWI38_0678p0010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FI-OER-3-3</strain>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000030">
        <property type="protein sequence ID" value="TBU05254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000678">
        <property type="protein sequence ID" value="TBU12662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0030p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0678p0010"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU05254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU12662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="168" mass="19100" checksum="A637943BBB758330" modified="2019-07-31" version="1">MRIRNEICKLCNKNYGVVLKNDNFNDIEVTIEGPPETPFYGGKFVVNIHIPDDYPFKSPSIGFVTKVFHPNVDENSGSICLDVLNQVWSPLYDLLNVVEIFLPQLLSYPNALDPLNSEAANMYINDKPKYEKVVKEYVDKYAIPNIKEEKTYNVDNSSSSVDSDSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR8</accession>
    <name>A0A4V2JXR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0620p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000620">
        <property type="protein sequence ID" value="TBU12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0620p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16824" checksum="97B5491A58576D8D" modified="2019-07-31" version="1" fragment="single">MYPLVVFGIASLLYSNKKIYLDLRKCFKNWIPGIFILTYITATLFLRTNSCASVMDPSSLQFAFLNDFWKNKLFERKKLSGVKYWLSCQDGKKSKICLGTHHFKDNLSDESFLYSENDFNCSLGISLYHHEPLDSFEIDYSAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS4</accession>
    <name>A0A4V2JXS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0593p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000593">
        <property type="protein sequence ID" value="TBU12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0593p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="606" mass="70127" checksum="54E9237E41B8E0F1" modified="2019-07-31" version="1">MPKKENITSPVNNNDTKNNNSLEDKNSMIEQQSESDIKEDKKNQNSEEKSDIKKDVNITSKTIINTKKNINDEDINNQEIQPSEYQNENPERKLLFENIVAQNDPIINIEYNNCSDIDNEYSNISSSNIDDEDDKSTYIEEETYNEIEYLSPEILNNCHNEDSNLSSNQDSSFGGPRSNARNATNLDNRDNMSNRHINGFLNRSNFSGIVLPDNYSLPSPYIYEENEASDIIMPTENDTSTNTFENQINGNNIFERLPQTIRFRTNRNIRNPEFIRSRIINDSERPLSNIPPLNTRMNRDLREEQNIFNPYTSRITNYYSFYHSLGSFEGKYENKFAGDSMLAYICESESDEDTEIGNPRILRRMNTLATENGTNVSGISSSDEEDDSSSFFMKPYVCSNCCNNDVSDEEYEYKDQNKENGTQEYMNHDEMIESDSDYSRQIYLWEYYMKYGKFAPEDTPSDPSSNDNSSDSNNFECEDDNFSSETKEITKIFKDFPHGQSKSEFNKQSPEKQTWECCKKENEMTNNSSNTSSSNSTETKEKNSRKTKKNEKKKQENSETNQEPQNNSEPCEEDTEECSEFNQDSGYDAPNTDFDSEGEYYAEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY00</accession>
    <name>A0A4V2JY00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0335p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000335">
        <property type="protein sequence ID" value="TBU13810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0335p0050"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="9022" checksum="764AA4669B362483" modified="2019-07-31" version="1">MVYDGHLNKTNFQILKTKLYISFEYDIYQCGVYIIPYVITWDGIVTKYHEIYLKRLQISKNVEAHIKSIVNKMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY76</accession>
    <name>A0A4V2JY76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0143p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000143">
        <property type="protein sequence ID" value="TBU20043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY76"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0143p0010"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12231" checksum="459867B830442AB8" modified="2019-07-31" version="1">MFDRLSRRGRHSYKTRSNVLKLVRTRVSKKLKYIHCKKKGTSQKCGICKQALHGVARRRPADFSRLKKSRRTVSRTYGGVWCACCLEKRIVDTFLNNEETVAQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB7</accession>
    <name>A0A4V2JYB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0059p0050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000059">
        <property type="protein sequence ID" value="TBU20513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0059p0050"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="13"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139925" checksum="33DF95AF9D712C78" modified="2019-07-31" version="1">MPTLLNNCTAKKTISVKIRIKPSQSSSDVPYSSTQITVNNRTYNFQHIFPPTASQPQLFEHIVPLLDSFIAGFNTTVVVYGQTGSGKTYTMGTTPEQMVYNYEGDSYSGENNTPYVTKGEDNTPLSIDIRNNTHYINNSENNTPCISTGNNNTPLSIGTQNNTFLNDNTVTNTPIITTTNTNTHIITTPNTNTSLSNTSNTNTPLSTTPYTNTPIITTPYNNTTLTNTLGILPRSVIYLFNNINVPIILSFIEIYNEEVYDLLSDNKVPLIIRENNGIPILTCVSKHTIYSTKCAFKKLNKGLLERKTKSTKMNLNSSRSHAIITLQVKDTLLTFVDLAGSERMERSGVKGEKVKECICINSGLLSLSNVINSMYKKNKHIPFRDSKLTRLLQPSFIGQCYTLVVGCISLEGVDIGEGVNTLVYCYRICCIEGYIVRRMGASLDYKEEVLKVRKENENLIGEIRRLEGVIDMLKRENEKLRRGVSDSKSRLEGVSSKNMLEAVNYSTNIQQGANYSTNEQQGVNISTNKQQGVSNSIYGYKGVENKDLLNNKVFTPSKIIKGLNIGNTTINNKKEYLHDRLGGVNRSVIGDSRLRGVNKSVVGSGLRGVNKSAVECGLRGVNRSVINDRLTGVNKSVINDKSTGVNGSVINDKLTGVNRSVINNKLTGVNKSVINDRLTGVNKSVVETRLTGVNKGTNISSRLTGVNRSVIGGIESKGVNNVTNMSSRLTGVSKELDKQENSSVNTPVVTRGIFNTSSNANYQRLLKDRLVNNKTPLSQDNKSTVVSTPLSQHNKNTVVNALLAQDNSTTVTNTPLLHTDNTNTNTSLLHTNKTNTNTPLLHTNNTNTSTPLLHTNNTNTNTPITLKRKDSNQPDSKKIKDDKRRVTFKINTTLTPVKYKKKFKVINTLLYNKGPVTGISAYKGFIYTCSLNNTITAYSINKGGVISTYEDKEGLSNLSVINGCYLYNSSSSLNNTPLLQDIDTSNNTPLFSNSPVNNTPITTNTSLLNNTPIITNTSLLNNTPITTNTSLLNNTPLSYTTPFTDNMTVTDSNVLYYSNNNFKVIDMKYNKEVLKIRTSSTITSMKTKGCYIIGGHENGNISIFDSRMYNKPLYYKNIHKSTIFSIDLYKSNIFSGSRDHTIGVFDFNLNNTLLLNPPHYDSVMCVLVYKDSLISGSRDCSLKRWSIEDKSVVKTYPYAHESWVKSLCLSDGFFVSGGKDCKIKGWGFNDKSLVSLGECSVKGGVNCIVEDEGVLFVGSQDKSVYVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE4</accession>
    <name>A0A4V2JYE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0017p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="662" mass="77859" checksum="B411FCC6FFB64ADA" modified="2019-07-31" version="1">MFMKYFYILCKLNIIYSSRYINTECYNSLKKESSQANYDLNTNIFENNKECLNEANDTEHFCNSCPILDVTQQIRTADNESDAQYEIKKEILSESFSNSEEKYLEGNAKDFHNLGNKVQKNKKQMLRYHPYKKRSISVDLSRNYSSETDTHFYCNKVEKQRTSDIDKHQAGLEFRNDTSDEHYNSTEQRKTPDFFLKSEVVDPLYIDSDSDTKSFLESSSTIDISKIAKLKLEIATESLEHKLDLLKKQYQEKIINTKGKSYAVLNESRKELFSSDIQTFISGDFYIDANYLQKDPTPFFDLIDSVAGKEENFWHKSGNPGILRNTGENMLECVEKINLCNDDSPIFTYYPGLIHIKHFIKNIILNDINLVKNSCLWIFLLKFVQSLSMFPLKNKNLNPISSGKNCCLQYNEYDAYNGDKYIFTLIRSQYELFDTMARHIFKKTEIFPGSTHMLDFINKSLYFNNKDIHISLGKHIGYIRVITDCILRMSPNTISIFILQMEKQKLINLNGGEFRSEISTFFWNISHEANILNDESIVDFQIIYKRIVLAYIDFFKHEALQVEFSKSKNARYSEHINFTLFNLFKPYCIEKLLINELNFKFWMQTAEALCVLFNFFLKCELNPQAYTDSYGIQAFVECNKRLKFIQSFLIYQYNSKMNFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KQ74</accession>
    <name>A0A4Q9KQ74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_2731p0020</name>
        <name evidence="7" type="ORF">CWI38_2652p0010</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002731">
        <property type="protein sequence ID" value="TBT96796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002652">
        <property type="protein sequence ID" value="TBU06050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KQ74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KQ74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2731p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2652p0010"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT96796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU06050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="140" mass="16595" checksum="04D45F6189BDBC03" modified="2019-07-31" version="1">MKFNKQVSSSRRKNRKRHFNASEEDRTKTMKCTLSKELRSLYGMRALPICVNDTVEVMRGQFKSIKGRVVEVIYKTYKVHVESCEVTKKSGQKVFMPIYYSNLRIHKLHIDEERMSYINRMVQSKKKVVEITSDTRLEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KSP4</accession>
    <name>A0A4Q9KSP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_2076p0010</name>
        <name evidence="4" type="ORF">CWI38_0309p0050</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002076">
        <property type="protein sequence ID" value="TBT97778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000309">
        <property type="protein sequence ID" value="TBU15687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KSP4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KSP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2076p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0309p0050"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="154"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT97778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU15687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="438" mass="50552" checksum="73D60467A5D33861" modified="2019-07-31" version="1">MRELETSKKKIEISPEIQKINSETISVLKKGGRTMLDKNLTLNLIEYLVNKRMSVSNNQKAVREKTKPVKLIIPILSIILTLVMIGFALYHIKPSLFDIFKNKKDSSIDVMKFAHVQLYGKNEILDCVTARITRILNFIDELSDGDLAEKITPTIKNFILYGNPGTGKTLFVKKVAYHIERNLRIKELREKHGESTVDDWTNDELEEKIKKVKSKVRFILVDPSNVNHSLVGESEKEIKALFVDAKDSKGHEVSIMVIDEADSILSKREDVKTDHGSSSRSQFLMGMDGVCTDLKTKLIIFSITNFQSKIDLAILRRHSNKIYFALPNTAERECLIKNMLSKNSKRFSSDEIQELVDLSNKLSQSQITRIFIEIFDHFDTISVKFDFSHCKDMFQKYKRSLFSKEAELIETDFTLRKNDLKYIYDPNTRKRQRNNIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUN1</accession>
    <name>A0A4Q9KUN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1689p0020</name>
        <name evidence="2" type="ORF">CWI38_1181p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001689">
        <property type="protein sequence ID" value="TBT98582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001181">
        <property type="protein sequence ID" value="TBU11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1689p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1181p0020"/>
    <dbReference type="OrthoDB" id="2193885at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="341" mass="38651" checksum="9C7DAF7D238DEDD7" modified="2019-07-31" version="1">MEKEEKIDLKKYKISGKIITNGGYIVLKGELCICITTSCGLYIERSIYKSVKPTILIKTEFTDYLYAEYNGKEFIPISINGNPSLYFLRIINLFYNLTKKIPENSIFYEMKFDEGFFVTKGRFIEESIKTGLGSSACYLVGIVFGLVDYDLSKIHNLSKLCYDINKIMNPKASGCDVVCCVEGSLIYSPLTYKPFKGKMAKIVLGSFGSSTSTREMINKEEIINADWNRVININNVILDRLNFTAQEYSDYSGLKDLYFKYLVALRHLSDKIVPNRQYKALMDTSDMNIYGCGVSGSGGEDCTWCLVPESSVNDIVQTWKKTFKYVHVVDLNQGPGIKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXN9</accession>
    <name>A0A4Q9KXN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1241p0020</name>
        <name evidence="6" type="ORF">CWI38_0523p0010</name>
        <name evidence="5" type="ORF">CWI38_0770p0010</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001241">
        <property type="protein sequence ID" value="TBT99718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000770">
        <property type="protein sequence ID" value="TBU12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000523">
        <property type="protein sequence ID" value="TBU13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXN9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1241p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0523p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0770p0010"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="111" mass="12728" checksum="532A6FE6D8D09391" modified="2019-07-31" version="1">MQAVTREYDALHRTCVPATFFSYKRSLRKIYPKYALLRLPCVNTREQASKYVGHAVVSMCKGIENKGRISKVHGNSGVVVCRFKKNLAPRDIGSEVFVRLYKVEENEVFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L706</accession>
    <name>A0A4Q9L706_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0484p0010</name>
        <name evidence="3" type="ORF">CWI38_1510p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000484">
        <property type="protein sequence ID" value="TBU02430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001510">
        <property type="protein sequence ID" value="TBU10857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L706"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0484p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1510p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="91403" checksum="3B150007650B9FE2" modified="2019-07-31" version="1">MLGNSTAKILMKSIYNEKTSVVLIIVILITFLKANNKIVFHFYDEKYVKQEKFSHTDRSALTPSKYVKMKFNDHEHSKCIECRKYIIADKNDFLLNFKNSDTDKSDIIIYLNQKILAYKDFLYFIKILDGASEYKENFIIHDFMRFLHILDIFKFQKDKVFHRIIRILLLSTIFNRNGSHNELNSDIKICVSPSLLNIIFYEFGKIKFFGKKIFQENKSESEVKRILNQNFDLSYSPHTEFIYMNSSLVYKIKQSIKTNPEFIYSFELIFAKFTFRKIILFYDKFICEIPCSVLNILFSCVEEFCFYYWNDVFSFETITEILVSKVLRNLIFIRCRFHSFSETFFGKLRSLESIYFYDSHFKRIGFPNQFYASLNALQNYIFTEITSYENTSNLLEKSNLEPYKITCFNIDLVTKSNKDLITIHDCQPNVFKVYSYNILCFNLSIFTFYIGIINLDKIRKVNIFLNNVLIKGMMLSNSSINLNIQKLQISDSRLTDNFITNILMFPNLKKLFILKCTILFPKGKYTNNESLRKVFLSGNTFENSLDIFYFINSLPNLKSLIYIRNSSLCLFTYPDTEKFLDLKYLQKLKIIEKKMFKPSLPIISRFESLIELDIGNGYEEGSLLKFFLDKKLPFLRNLSINRFEIGIHDKQALKDCTKIQSLCFLDCKFIKISFSELFDIKKEYLIDNIFFYDNILTKNDIEFLSNLKHLKSLSFEIKTSFSFPIKWFKYNLMKIAKLQVRIEISKDLYQELNQFKEVINSYNLKIYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA29</accession>
    <name>A0A4Q9LA29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0112p0030</name>
        <name evidence="3" type="ORF">CWI38_0338p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000112">
        <property type="protein sequence ID" value="TBU04603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000338">
        <property type="protein sequence ID" value="TBU13797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0112p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0338p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15925" checksum="BDE38D6EEDBB6BBB" modified="2019-07-31" version="1">MKKETKVKTIKASKSNKKSKHTSDDVTDSDYSKLSCLSSPKNHELNNEFKINELKHYDDIEICSNNCNTFFYKNGNPVKLTVQEMQISWQFFDWMNKRDKIYNTNVPISYPKKIMTENGLIQKNMEQANFRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGC6</accession>
    <name>A0A4Q9LGC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2512p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002512">
        <property type="protein sequence ID" value="TBU06756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2512p0030"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15523" checksum="EFD896358D0B59B5" modified="2019-07-31" version="1">MTWDGIVTKYHKSHIKRLEIPMNVEAYIQSVVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKTKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGE6</accession>
    <name>A0A4Q9LGE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2565p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002565">
        <property type="protein sequence ID" value="TBU06495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGE6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2565p0020"/>
    <dbReference type="OrthoDB" id="2196386at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="496" mass="54285" checksum="75AE2C006092FC6F" modified="2019-07-31" version="1" fragment="single">MIILTTDQINSVILEYLIQEGYYHTHFTFSHESITPNIKPLYSLQNLLKKGMQYSYIEEHLYCNKECFSLYSLTDKHICKYRSKELSVGVSTKDNSNRVSVSNCMVGSKDNSNSMVGNMVGGKDNSNRVSVSNCMVGSKDIDNSMVGNMVGGKDMDNGNNNSKDIDNNNKDIDNNSRVTGRRVSKDKVINKDKGSSKDKRLKDNIDIEITNTSSTNTSTSNGTNTSTNNTSSTSTNNTTTNNTTNTSSTSTNNTTNTNDNGKEISLSINGSTDNKGVITLKIENVSNSRGVSGKGSKDKDREVVEGVNDSSGVVEGVNDNREVVEGVSKDKDRDMLEGVNDRTVLEGVNDMDSKNNDRTVLEGANDNRDIDTNNIKEDIDSKTNDVKEDCRDNTLIGSTEDNTLLNNSIEGIKDNTLLNNSIEGTKDSTLLTNTTSNNSDNTTSNPYDNTLLTTTSPLSNLNVYSSSISYNVLPLKNIKEGFICKWNNNNKLAIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGX1</accession>
    <name>A0A4Q9LGX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2412p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002412">
        <property type="protein sequence ID" value="TBU07358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2412p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19147" checksum="B966795B1163CD1C" modified="2019-07-31" version="1" fragment="single">MTRPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHN3</accession>
    <name>A0A4Q9LHN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2422p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002422">
        <property type="protein sequence ID" value="TBU07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2422p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="504" mass="57839" checksum="81641A35BE62046D" modified="2019-07-31" version="1" fragment="single">MLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARNNELECVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFLGADGVCQHYGKSGKTVDHLATRCEKMLGHDYTRWHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDIGIKTDVKIRRNRSDIFILDKKKNKITLIEEGITSQDSLQIVESEKLRQYDLLANELGLIYKCSVVIIPYVMTWDGIVTKYHKSHLKRLEIPNKLLKETVETISFDRRRGLESGLNDKESGERASMGVIMRAEMHEPTINIKEVSDLEEETEGVKEKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKM8</accession>
    <name>A0A4Q9LKM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2336p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002336">
        <property type="protein sequence ID" value="TBU07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2336p0010"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12553" checksum="DEE45D18860D5563" modified="2019-07-31" version="1">MHPILEGNRQKVLHSILDSVTAVEQERPRSAILAVRKRFERMPRKSCSALLRYYNRKFSRTVDIDVLKKFKQNNAEREIRQEKKRERRRIVTCLTDPCSLIDNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKP4</accession>
    <name>A0A4Q9LKP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biogenesis protein Nip7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2259p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002259">
        <property type="protein sequence ID" value="TBU08466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKP4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2259p0010"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="123"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU08466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24111" checksum="E6FCE28092970802" modified="2019-07-31" version="1" fragment="single">TTKPFIILLLFAFFSVKFFYLYFYVNYKYPLEMRNLKSEEQEKVFKKLKKFIGENTEKLLKGHRLFLHKQKVFHVSDELEKNASSIPKDDLVSIGSCLGRFTKSMHFKLTITSLHVLSKYALHKVWLKNSAEMNFLYANNILKSHILKMSEDVPINANVFVFNQNDLPLGFGVTAKGSTHLSNIEGNTLVVLHQADTGEYIRDEERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMW1</accession>
    <name>A0A4Q9LMW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2125p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002125">
        <property type="protein sequence ID" value="TBU09708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2125p0010"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="556"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="912" mass="104066" checksum="69AB9168598E6D7F" modified="2019-07-31" version="1" fragment="single">MAVIFHFENRMDNLTIKIDLIENQICQGHFTPLNVIGESFEVIISTEDEGKYYLHNTSLPPNKETHFSFNTYEAQTILIYMKRKQIDNSHVPNNYVPRIELKFDSQFDTFNKEVAKGVRVEPAIAALTNLQKLLHDATIETEVVTNTLNMWIGNFNKLVASSLYVSVLTLLLFIFFNVLSKNIKNEKIKAVKHLENSAGEILMCDVDVAMLYERLPPPPTFHDTTHQPPSSSCQTSPVYLVDTIPSFSANSGTNLNTDAILEGNRLMVLLSILDSVTARMPRNGWPATLRYYNEKVGWTLDIDAFKKLAQNEAERKIRQEENTERRRIANFLTELCTMTDTTDQIKQISEKEIEKVMIRTRKLPSILVDSKVLDLINRIIGKYADYYVSMTITAVARIIQAARIAWKENIESKISKLVLSKDLLEKARKQTKLSTSETKSLKKIMQEFNLNLSSVTDLSVALVKKNESLNVFEKKITMHRSTFPGSILSGLSERVESEHVVSRDEIDDYLITFVSDNHPTKFPSLDEIVSIINWLPNWKAAVIDGIYNFFVEKLTTLNKYIYDICGLRYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRCLLAENQLEAVKGVQGVKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIEVIISKWKIEISLGPEKIMNQKIQRGILQGDSFSPLLFVLCIDPLSRKLNEKYTKVTVQTDAESHSTNHFLFIDNLKLIAKDSSTLSAMTGEAKEFLEVIGLEIYKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPKSKSFEEVQTKLIARVERLLLRLEPAEFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHILLQLLDCLEKSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNU9</accession>
    <name>A0A4Q9LNU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0087p0050</name>
        <name evidence="3" type="ORF">CWI38_0288p0010</name>
        <name evidence="2" type="ORF">CWI38_2005p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000087">
        <property type="protein sequence ID" value="TBU04803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002005">
        <property type="protein sequence ID" value="TBU10123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000288">
        <property type="protein sequence ID" value="TBU17095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0087p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0288p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2005p0020"/>
    <dbReference type="OrthoDB" id="2191506at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="177" mass="20798" checksum="6EA80BD574910EBB" modified="2019-07-31" version="1">MNNSIPFSDLISEINFKNKRICIVEHEYCCIDFIIRDLLKILKKNNQEINILSFYNSEDHYEKIIDFDSKSTIKIQSIYKNEIIENSYSYLIIDDVFTGKTLFGIKCKEIEGIYIYRSNSATETDMCSYDICILIKPLKSGVSTVYDGIIEIHQFDRTIFTGKYKVFRDETVYYSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP72</accession>
    <name>A0A4Q9LP72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1934p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001934">
        <property type="protein sequence ID" value="TBU10218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1934p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="34377" checksum="E78D6837C0F26ADB" modified="2019-07-31" version="1" fragment="single">KPRPPKNNSIEIEKLNEPENNILEEILLSLKNIYNLFGFESKKEVKSIKEIKLMITELFFCLKEKFTEECKETFKFEKEMIKKFLTNLFKTDKILETIESKKKYKKNKDLLISNLNQILETKNYLSLFDWIKDILNYKNSIHLKYISKLEKEFNKKINNYGSVNNKLKLEINEKDQQVCKLQSEYDLIKEKLKTLEYLKNIFYTKDLETYIDKGTDILKSIKEEFTNEFKQLNTRNTILAKENEKMKLKIQNLQEIIENLVQKLSKKKNAQFIIEDLKKDMEIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ7</accession>
    <name>A0A4Q9LPJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2164p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002164">
        <property type="protein sequence ID" value="TBU09280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2164p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020203690" evidence="2">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="238" mass="26132" checksum="ABC5A8D9675DD5C7" modified="2019-07-31" version="1" fragment="single">MIISWLSLYLLFTYVMIVKPNESDSIQAPGSYIYTLYGNLNTDEGPNSGSGFTRTNSGGNGMDNSPVNGFNAHSFTNNYFPLDNPSVIGLWFGLNDAFETVAPVSMDQTNGTNDLADYTPNDSITFGNNGIEESEIMDQTNMDTNSTYQSTMFCGNGDSVALGSAAMEQNIIDEDRNSDMLVENQNHDNPLFLGSTVDEATKNGRQLYTTSLSDKDDLFFLDELDLVFISDAIESKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ10</accession>
    <name>A0A4Q9LQ10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1995p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001995">
        <property type="protein sequence ID" value="TBU10136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1995p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="17482" checksum="C476BCF2E189A09A" modified="2019-07-31" version="1">MEKEENYKFERDKSFEYLLEAARIEYIKMWEDQLYQNIDIYPQILKETTSNEMDLSYYDTDMFEEPGYFYDSIYSSDYYTEENNLNYRKCRRYESLEKREERLRKNRERERAIRLEKCRERIRRLRFFRKINKKNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ69</accession>
    <name>A0A4Q9LQ69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1949p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001949">
        <property type="protein sequence ID" value="TBU10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1949p0010"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17117" checksum="F29900BB7E271FB6" modified="2019-07-31" version="1">MEHLNNVVYAYYRTIHCAKNKSTFMLFFAQPGFKNPLSRSIIVEKETSTMVPAIDVHLDIVLVEENAADTEWYLEIALIDIMIPSDVAKHSKNYRERILESNNSNKLKRDLSIGDQFLIKKDFDMNTKTKKAPFESFYDISVYTVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQD2</accession>
    <name>A0A4Q9LQD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1580p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001580">
        <property type="protein sequence ID" value="TBU10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1580p0010"/>
    <dbReference type="OrthoDB" id="2194794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="53" mass="6144" checksum="AB67238EFB6C7171" modified="2019-07-31" version="1" fragment="single">KNKVIRGGARTEPQLRILICEKFNEITGEHCSSFYRKMLGYLQKSEVGQMILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR19</accession>
    <name>A0A4Q9LR19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1466p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001466">
        <property type="protein sequence ID" value="TBU10938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1466p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="11938" checksum="D105D52153E1EFAC" modified="2019-07-31" version="1" fragment="single">MEKDIFRMNYSSKEYKGIIVVRNIKEYFTKEYSSKEYKGIYYSKEYKGIIVVRNILVRNIKEYSSKEYKGIIVVRNIVVRNIKEYSSKEYKGIIVVRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR24</accession>
    <name>A0A4Q9LR24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1455p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001455">
        <property type="protein sequence ID" value="TBU10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1455p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26945" checksum="7BE734CA3CFC9D3F" modified="2019-07-31" version="1">MIFDSEFCFKNIVDLPNKSLMGHASLLLGRFKPVLSTKIKLSGKLPGFQPINDLDANLKKSFNLFSTLKANYKIKAAWRFENGFVEGEYERQCNLKTFVTEKIQELFNEKNILNTELLSIQEYSSKCKFSTDGLIGSPGYRREIKIHLSWQRLPYSVQFFLKESNENTRKYGLICSFTSNDAVEFEILSDKDLIITKIVKITKERFVFRDLLASYEYEETIGKYMKEIMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR38</accession>
    <name>A0A4Q9LR38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1458p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001458">
        <property type="protein sequence ID" value="TBU10958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1458p0010"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="30440" checksum="7D13EA245F487485" modified="2019-07-31" version="1" fragment="single">RKAVILKVENNNNTYPSLIKNFLKIKYGLEKEVTKKKLEEPQLANLYNEIENRKPHSRLYSARNNKQVSLNNSSKWLKKGIVGLRNEAGFCYFQDRNVFWDAEGMSTRCEKMFSPDYKDDIRSGTISHSVQEILDNEYAEIKVDTRIKTDNRITLIDVGITTQDSLRIYEVLANELEAYINHSTQESRPNAEESWKNNRQRGRGSEIGKYKTYLPLILHGMTTAKEPTTNTNEELELEEEIEVVEIVERIILKRKICVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR52</accession>
    <name>A0A4Q9LR52_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2021p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002021">
        <property type="protein sequence ID" value="TBU10101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2021p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41742" checksum="16DB4E4312924AEC" modified="2019-07-31" version="1" fragment="single">MQGFLISYNRGKEGMAIKEIKTILNSLDCNTDNKETYDIDTLLNKKIEIPKDCITNNKETYDIDTLLNKNIEIPKDCNTNNKKSTNIDTLLNKNIETIKKSNFIPLNKPKLKTLSIIKNTSQISSLDLFKSIKKKKIKTKYIQRMIPLSFITLKADIQTHIKSYCDIINKDGGTYKILYKSRCSNKEIKEKVFEIIIFYVTNTVNLDNPDNYIVVEVMCNILGIGIFKSCDFNINAKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK1</accession>
    <name>A0A4Q9LRK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3441 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1416p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001416">
        <property type="protein sequence ID" value="TBU11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1416p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT protein C-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="41774" checksum="85910739F569817A" modified="2019-07-31" version="1">MEENKKNKGRDGIKEIGIDEMEENKKNKGRDEIDKNTFKNIQNRNIIRYDDFIFVTSLFGDENVEYCFPYCAPWKSLRNNKFKVRLLPGNVKKGKLIKEVVGKFLGQANEFEKGFIKKVGVEEFMEAIFFGLSKILGQSEIKSKIRIAAEQCKIATFLAETCTLTDTTERLKFEMYDPNSKSSKSIVDSKILDLKNRLENIDSKICSQYFPKIFLESSSVTDLSVALVENNESLNVYKKKITMHESRKKLQRENCMLELFGMKKFWNNIGLEINTKNQPQMMRIIVDIRSNPTCSSFDELEQGDFSNLDDEKPAVLEKNKIHLSQSQKKRIYLLLKKLGRSLQGVELQSEHMLMLTFRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK2</accession>
    <name>A0A4Q9LRK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1494p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001494">
        <property type="protein sequence ID" value="TBU10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1494p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14658" checksum="FB9656EBBCF913BD" modified="2019-07-31" version="1">MLGNLENLISFDLINCFLLENSFSELFDEEKKYIIEDLVLNSIDITTHDVFFISKLKSLKNLTLLYCEFINKSYESLRGIYFERLEFYRFAAIDSCHDDAQIVHFTEEFGPNIFSQQTEELSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV9</accession>
    <name>A0A4Q9LRV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0380p0010</name>
        <name evidence="5" type="ORF">CWI38_1780p0020</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001780">
        <property type="protein sequence ID" value="TBU10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000380">
        <property type="protein sequence ID" value="TBU13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0380p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1780p0020"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23204" checksum="75C34900C50CB7E2" modified="2019-07-31" version="1">MISKEIVVDGKDHIAGKLGSFIAKHLLEGYTIKVVNADLVVFNRSLKKAVEWYKDYLRKKSRINPLRGPFHYHEPSKLFFRVVKRMVQYQIKKGKNALSRLTIFEGIPQDLIDTEFMMCPKAMRGVGRTFPDKKFCSFGQLCSRIGWKHGKLLDEIRKEQESIIQRKKSEMEAKQKEINEIRSSVAFQREVNDLISKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY9</accession>
    <name>A0A4Q9LRY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1863p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001863">
        <property type="protein sequence ID" value="TBU10305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1863p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="28524" checksum="EBBB338B0E9FD67C" modified="2019-07-31" version="1" fragment="single">SKVIKIVKFILEKSWTRTIKSIFYLIHLYYKITCKLAQFLKKIIVMIYNSCLLPICVYGGIEYKRIPTGYSKWQKSYRLFAISLYGIHIFSEKTITTLRKNICFKDIGAFFGFTEISHDNMEAGINELEAQDTNNQPEIIRPNKTDKTSAKNNTSATKNKVQSKKTVKINKPCVINHNIPTDNEISCKGLKRKNPKIAPYDTIVVETLDETILKKVQQSHDQGDITSLSTSEILGFHIADGIYDGISFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ0</accession>
    <name>A0A4Q9LRZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1319p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001319">
        <property type="protein sequence ID" value="TBU11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1319p0030"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="13051" checksum="EB683B5E88235830" modified="2019-07-31" version="1">MIPIASPLANEKITGKIQKLLKVKRRAGVLKRGASACTKAILGGKSGFMVLGGDVSPLDLISHLPVLCEEKGVPYIFVNSKNDLCDASKRKLPSCCCFFSFDKEEEEDMKNILKYAFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS30</accession>
    <name>A0A4Q9LS30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MutL-like DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1263p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001263">
        <property type="protein sequence ID" value="TBU11329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS30"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1263p0020"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="222"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="323" mass="38159" checksum="581BE837C0F6CA9F" modified="2019-07-31" version="1">MEHFLTFFKTLKSGGGNFLKMNLYKSTIHIDNTISLLNDNKKISNSIIFLQQPIIYEKFISSTTKNTKHKELIYFTRINDIPKPELSTYKIQKNKSNWNFDNSNIHSSTEYGLTLIYNMKPIFLQKFIFELKLNEIYFENGILFIKIDKIIEKIQNNIFKDNASCFPNFITSEITVEFQVLLDENRNKLNIKYKNQNSKKPYMFHNSNTVNISKYEISKESLIGQFNNEFIIIKNHKSLFILDQHAIHERIRLEKFIKNRNIKESITETELEILKSKACRGAIKFGDNLNDKELTKILEEIKYCDHPFICAHGRPSIRYLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC1</accession>
    <name>A0A4Q9LSC1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1196p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="PITK01001196">
        <property type="protein sequence ID" value="TBU11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1196p0020"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="322"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="522"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="830" mass="96264" checksum="EFAE51BC75906A4F" modified="2019-07-31" version="1">MVKLQSSEDDDYIFTKVVLKAYEENENKEKEVSLDLKNISVSSDVSEISFLNKNNYLCEEMDEKDIVIVKERTVDFQESSSVGNMDIHEGQITSSLPSSDRFIDILEANTSNENCDEIEIVSHRTVKPKISKKINDLERGNNNQIHRLDNIKSKSKIDDREVEEINNNYDFEITENIKSKSKMEDREVEEINNNYDFEITENIKSKSKIDDREVEEINNNYDFEITENIKSKSKIEDREVEEINNDYDCEINENIKSKNIMGNTATDDLFVSNLDNEIELENIFDSEEKNQKIEDKPISPAYTVLRHIFKLQNFRENQEKIIETTLAKKDVFVLMPTGGGKSLCYQLPALLSDGLTVVVSPLLSLITDQVRNLLVKDIPALALNSSISLSEKKLIYDVLYKIPLVSKLLYVTPELIAKSAQFKSLMDFLISKKLLSRFVIDEAHCVSQWGYDFRPDYKDLSCLKKLFPYVPIMALTATATRKVENDIIKSLDLKNCNTFRMSFNRKNLRYYVHKKTKTVDIDIVSFINTYFPDSCGIIYCTSKKECEMMSERLNTKYNLKTHFYHAGLSTKERNAVQNGWNNSEYNIIIATIAFGMGIDKKDVRFVIHYSLPKSLEGYYQETGRAGRDSLESVCVLFYNYGDKKKIEFMIDRNDAGYDQKQRQKDDLRYVIQYCENSTDCRRELLLFHFNENFSKTECKGTCDNCERGFKGIKKDITKQCRELSQLLKSTNRKISVNQIVDVYRGSENKKSLEFEKNCFYGRGKDLKRGEVERIVRFMVTDGYFIEKIEVTVSGFSWAYLKPGKQIKGKVEMVVEDEEINKNSVKKSKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG4</accession>
    <name>A0A4Q9LSG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit G of chromosome condensation condensin complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1166p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001166">
        <property type="protein sequence ID" value="TBU11513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1166p0030"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="30024" checksum="1E53A7C78661526E" modified="2019-07-31" version="1" fragment="single">MPLISENYNLEEIFNEIQQCNTTKYLQNLEKFKTFLNQEESFDENFINILNVILFSDKKEIPSKITTFIKKTIQEMSYNSKEKKFLINFCNYLKECIDSKYKNVRKNSIFLISLIQESISNQDVKIKIFEKDFIIKIAHHLFDKESSVRRETIKALESHQSEVVFEKTVIINVYKDIIRYDTSPDVRKEALKNINPIPTTFNAVFEKSYDINLGVRKMFYYNYLPKLSIKDLSLENRILLLKRAFLEREFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI7</accession>
    <name>A0A4Q9LSI7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_2561p0010</name>
        <name evidence="10" type="ORF">CWI38_1304p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002561">
        <property type="protein sequence ID" value="TBT97024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001304">
        <property type="protein sequence ID" value="TBU11247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2561p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1304p0010"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT97024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="182" mass="21284" checksum="1CD7065D64C45985" modified="2019-07-31" version="1">MLHNDPLRKAFEVDEKPRFDFKIPVYYRKTYKESRFVDLEFFGLSYYQRAVCFLIFFGLGIFTFIYSMFNILSAFFNPAKFAFPYALSNFLLFSMMGFVLGFRTYLGGIFQKDKRPYTVMFLASTFITLYSAIKIRSYFLNFAFAILQVTSFVVFVFTFVPGGTKGLSGISKMLFARFTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK1</accession>
    <name>A0A4Q9LSK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1144p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001144">
        <property type="protein sequence ID" value="TBU11553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1144p0010"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="629" mass="72111" checksum="6B411AAD75AE1990" modified="2019-07-31" version="1">MNLEWKNVDIELVNKNKNRREKYVRLITNANGIVKSGSLCAIMGPSGSGKTTLIKGLVGRIPSGAKTKGDILVNGKARDYENWCKNIGYVDQDDCIYEKLTVLETVTYAARFRLKEQNINILKKVEDLLDELDILDISGSRMDSISGGERKRVMIAIELITEPNILFMDEPTSGLDSSTAFNFVKLMQTLSITHKMTVIFTIHQPSVETFSIFDQLILLSDSHTVFSGQAENAEEYFESYGLKKRELSTFPDFLAEVLKVKHKYRELPEHQAILTKMINDVEIKYHVPENMAISDQNEIAMSYIPNKRHIMILLNRKYKTNFSISKVLFSLVIIGLSFYSFILTAFGLLEKENSPKIITTYFIINQAVHDETFFKFANFVQIYGDKVSAVLKPSIFMQFLGILFAYSMIASTGVFSFEYKMVKRELGVATYSIGSYYFATFLFEIFFYLPFFILINIISAILQGSLIPWEFYLFVIFGLLAFIPVILFFGSLTKRTKTIYVIVSFLALTWAVPPVFYVRSRRFFTDQNCYPNIFFMLIGSIFPPLHFKALCVALSYKFSSQSSDILKENDSIRSTCDQLSANLYSYLYNSMAIWQILLLFVITTVFYVVFALVALTLRLKPEQRFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ1</accession>
    <name>A0A4Q9LSQ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1352p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001352">
        <property type="protein sequence ID" value="TBU11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1352p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="91195" checksum="14A64F8346BCE07D" modified="2019-07-31" version="1">MNLYAYVKTKRMFYEKFYVTNLILWIFFQINFVTAHKFVYWFEKNKNSEILFYHEIETNTAVNNEFECDYYLKVSIKSNKPQKNELNRVYTYKKENFIKYEVFDKILVANTMEDNNGKIECNFDIIYDLKLTEDISSLPEKIDFNLVITLFLTFKYLKVVRQENVLKFLEILILRMYAQQYGIDSNNKYLVLENLFKPDIFKNLEFFNKKNLISALLNNFMIYHVFYEDNLILLNNSKDDYETDFFNEHIPYKNLLINDYRVFYKLERVFKNVSISNYFHILLNEIDIKSLIINNFEESEKHKADFRIFKRSTVSFKSIIISNLLYSSERILYELNKAIDLKLEYFGLCNLSVENNYFLIFLKSQKLKGIILNNVVLKIDIHFFDVYMNKNKTLKYIELKNVETMFTWIEFIDRLNIEKIILSFNSESVEENFIRGFDSLENTLGVQYLEIRFFNYRIYKELCKILRNFPALQTLKLSNYQPDKKMNRKFHKVIENMKQLSTLIIEHEYFSNKFLNSAFQNKRIQVLHINNYIYKEKIFKLEVLSNPNHLTHLGLRSINISASSLVQIFRLKNLESLSLKFCDLEAIKNFKTHHVMATNIRCLNLKGSILNSFRDFDILEKLNYLEKLTLSGLQLHLCSLNKLNSNCNLTLKKLSYIWGILSADDLNRIKYLEVLIQLNISRCEFLNTSLCELGRNCNFLSSLKYLDLSYVELTLNDFLYLQSFKHLRNLKISFFRINTTITDIQNKKNNTINHFTIKSHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST3</accession>
    <name>A0A4Q9LST3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Elf1-like transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1158p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001158">
        <property type="protein sequence ID" value="TBU11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LST3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1158p0010"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="348" mass="41207" checksum="25565C62C6525C56" modified="2019-07-31" version="1" fragment="single">MGRKKTRRSQIKTKKRSDRMENRFNCPECNNESVVKCKIEKSSRLGYAYCTLCEASYKCSVNNLSHPVDVYSSWIDNFNRKDLDLEEKSIIHKDIELSNEEMQRLNDLRSYCEMVKIVQNKDDTLSPTTNTDDNSIKIIYPGNIKFKIGIIENMKSTTNPKFYVGHLISKEVFEYMIEILCDINRINFKLPAFLYIQLINGIIGLKPETNFYFRSLLSRLNYWAFTGNHLNEIIENKNKLEFDNSFTKQFFYMTAFISYLNYLNISVTFLNSKMILSSSSITNYNTYPSKEKLDNRYNLIFEDKTLMVFFTNINEHNKLLYEWMFLEMDNIETITFLDLKSLNYINIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSU2</accession>
    <name>A0A4Q9LSU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1502p0010</name>
        <name evidence="9" type="ORF">CWI38_1094p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001502">
        <property type="protein sequence ID" value="TBT99010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001094">
        <property type="protein sequence ID" value="TBU11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSU2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1502p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1094p0010"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT99010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="222" mass="25487" checksum="CA0373EF44280FD7" modified="2019-07-31" version="1">MALEPLFKKLWEIIYEHRAKLIIGISILVIVAIYIYKITKRIEKIEDLPRNSKGKVLHGLVTYVCDGDGFKMFHIPWFRSGKITGKLKTLSIRISSIDAPEIGKFGNPDQPFSQEAKKFLSDLILEKNVKIKILGIDRYSRILATVYYGPFYNRKNVSLELIKKGFACIYRGSDAIYDKHKDRLFKAEEQAKKNKVGMWKSKNLVLPSVYKQNLKKLASGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW0</accession>
    <name>A0A4Q9LSW0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1084p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001084">
        <property type="protein sequence ID" value="TBU11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1084p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="225"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="366" mass="44031" checksum="7AE9316109024FF4" modified="2019-07-31" version="1">MVTECIKEDESDFYNVQNELSRYKIFYLNRFILTEIIMCLILTLFINDKFRNKIIAFVERNKIFEENRFFIRSLDLNCITLISFCVFLIDYIHLLNKYGIPDSFIDQAFYVKYLISPLLYIISYKIFNKFGRLPLYILIGFLLLFLQPKILIPLVLNMNRLLKGYEKFDINLFDDRIKRKLIEFNIEDNVYISKIPDSVKNMGVFKYFTRILVLIDGSKREYENNPKMLNSMFSHELGHVSRGYKDMIFISVCEWLLDILIIFLIDFFSFRSRKSSKLSRFTNFFIFCLVYFLILRDYTFVFSLILKRNEEVYADKYAVALGYREELAYSLFKITYKFSCLQESSIYNFIKFVHPSTITRIKRICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX9</accession>
    <name>A0A4Q9LSX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1634p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001634">
        <property type="protein sequence ID" value="TBU10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1634p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="483" mass="56762" checksum="1CC52AD14A8413C1" modified="2019-07-31" version="1" fragment="single">MEILRTKKIIVGLGILIGTIVVIIGSISLFCGVKAKKKLSKEVKQFNEFNEFTASSYAKRLRKLIDRNKNIGIFNIKEEGKLSISPCLSYQHANELFKCSELFLYGNDENKEKLLEGYTIDDIMTKSYNVVFLPYLMSVEKLNIFWKKYKPDILTKFGLVLIRGASEFNFIDKIISLLQEMSRNEGEFGYITIEIKDNSVNVLSKIHKIADMITNAEFLYEKTEKISLKSKNTTDFVIFLLSKANIFDLNNIYDTLTKISSDTLLKGFLLDILENFLGILFIPDIDKLVSRYIPATEETKKMISEFLQEFRKEENDLKWILNEFERFSWVFARKLLNIYLENKEDVMEWINEPENAIESFNKFFNEIERLDISSQILRQIKIFIFETEKNTTIKLLKLFKVLLENINEKNIQINTMNNNQDFKTFVKFFKSKFIGIFLENEEMIEYLKNIVVMLENFSSDDDLLFKMHIKLRDEMCLSLFKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT42</accession>
    <name>A0A4Q9LT42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1043p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001043">
        <property type="protein sequence ID" value="TBU11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1043p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020193062" evidence="2">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23592" checksum="C7787B2E066BB1FD" modified="2019-07-31" version="1">MSLPIIFINLCFLQLILRLEIFEITSTGFDLANIEFGLIKKEYPMYNLVLVLGILMRFFSSRTMKHYSIDRNYAVLSAFSMFTLSLISVLYNHKEFIQEFEIISNCIVTYSFSLFFGAISYFLITTHAMKMDFHYIISFECVFLILSQLLFKSLQNNSFFVKSIVEKKLISIYFPFMLIPIVTLIFIYLHKKYYYIEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT57</accession>
    <name>A0A4Q9LT57_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1562p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001562">
        <property type="protein sequence ID" value="TBU10765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1562p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="90307" checksum="0098A012C93CA1FC" modified="2019-07-31" version="1" fragment="single">INFVTAHKFVYWFEKNKNSEILFYHEIETNTAVNNEFECDYYLKVSIKSNKPQKNELNRVYTYKKENFIKYEVFDKILVANTMEDNNGKIECNFDIIYDLKLTEDISSLPEKIDFNLVITLFLTFKYLKVVRQENVLKFLEILILRMYAQQYGIDSNNKYLVLENLFKPDIFKNLEFFNKKNLISALLNNFMIYHVFYEDNLILLNNSKDDYETDFFNEHIPYKNLLINDYRVFYKLERVFKNVSISNYFHILLNEIDIKSLIINNFEESEKHKADFRIFKRSTVSFKSIIISNLLYSSERILYELNKAIDLKLEYFGLCNLSVENNYFLIFLKSQKLKGIILNNVVLKIDIHFFDVYMNKNKTLKYIELKNVETMFTCIEFIDRLNIEKIILSFNSESVEENFIRGFYGLENTLGVQYLEIRFFNYRINKELCKILRNFPALQTLKLSNYQPDKKMNRKFHKVIENMKQLSTLIIEHEYFSNKFLNSAFQNKRIQVLHINNYNYKKKILKLEVLSNPNHLTHLGLRSINISASSLVQIFRLKNLEFLSLKFCDLEAIKNFKTHHVMATNIRCLNLKGSILNSFRDFDILEKLNYLEKLTLSGLQLHLCSLNKLNSNCNLTLKKLSYIWGILSADDLNRIKYLEVLIQLNISRCEFLNTSLCELGRNCNFLSSLKYLDLSYVELTLNDFLYLQSFKRLRNLKISFFRSHGHKFDFSMNSYSNNYFFSRNIYRERTKFKLIEYFGEINSSENYIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA3</accession>
    <name>A0A4Q9LTA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1170p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001170">
        <property type="protein sequence ID" value="TBU11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1170p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="584" mass="68688" checksum="74E04DA21E7C972F" modified="2019-07-31" version="1">MFFHIIFCLCSLQENSEILLTDPTIAENTHIDLICLRRSNSYVENYLKKIDFRISKEKLEEIGSIICFCMELSENYNDKSDYDYLLLYVSSIFYIIFISDAIHYFQCNPELFFNVSTFLKLYKYLNQVQNHESFLVNLTLDFLINKPEFMSLLKYRGLESDIDSIKKMLPELTLNIKRSCTQNSRLDVDIWENIQINLDIHNPVSFRLSEYLQNASFERIFIFFLKIKTDVALINITALWDVDPEIKPYKLIIDQKFLDEIFLTEEWFRKKYSAMVNQNSAAELMKLVLEPFIDGVLMDKKSLECIFGLSRKDFSNTSTLVDEKFPQILLELFAEKTNINLLKNLYCFLKKIIKPEIYNFIPIVICLKCLCFKQEFSSDMKLQRIILEIIFFIAILKRNNTEFEEIDIENRLQKEYLRFLKHDIIVKNIFCEKDTNGDPLISKIIPKTLNFLQTAVYVQYFADGKFLVLFSIALDTKHKEFNINMNDSFEKRMKKILICLMEDELKDLDLKGSVCVPSTESKSLLETAMTSTKPQGEIFEKQARVPSEGSNEIFKKDSDKEKVNLPISEENQKRLPETEKKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM6</accession>
    <name>A0A4Q9LTM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1170p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001170">
        <property type="protein sequence ID" value="TBU11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1170p0010"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF827">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="262" mass="30738" checksum="37217C788145460E" modified="2019-07-31" version="1">MEDKILFLNMEKHENIEFSIFGIFDGHGGYEVAEYCKENFIKFLKKEISNVTRNNLHVYNWESIFKKTFIEIDNSLLKEKYIYSFTGTTALLLFINHNKPMNEFYIINLGDSTAFKCNETRYTVLNEHHNLRNSVEAIRLRNTNINIFGGRLDGKLDVTRSLGDFYFKKNENRNLDSCDKELSPVPECLRIKFAKEEVLSIMSDGVTDGIDFPSLHKIIIQYSFEKNQLNFLPKRIFEVCLMENPDKQRSEDNMSIIIIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU97</accession>
    <name>A0A4Q9LU97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0844p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000844">
        <property type="protein sequence ID" value="TBU12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0844p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="32701" checksum="CF9FD143F505D6C2" modified="2019-07-31" version="1">MYKALACFSRARDNTRDSYIRIGDVSHGKHTNIPRRFQIFQLNPHYDLFHNGFCVRMHSEIEIFEENTINKNLMIDKFNNLFGETMCIYSGSYSYYIVYNEKYETYNNKISKKSYKLNLKIHSINLRHELQILKPIYYFYMRSRVSFILKNIKIEYSYFNKYEKFSAQSRKFRIVFKHSKSIFELNSNFLGCIVKKFIPAASTYICILRETYFDIIDLEYEANSNNFKISQIKKYNVFQTSSPVEFSPSLSAQEVLSIKDFLDMLFFNLEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA6</accession>
    <name>A0A4Q9LUA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-variant domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1329p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001329">
        <property type="protein sequence ID" value="TBU11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1329p0020"/>
    <dbReference type="OrthoDB" id="2188690at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="33419" checksum="4F7C4AFB79BD5E7F" modified="2019-07-31" version="1" fragment="single">MHSPQTCKICFLPSMQNKPLFHPCKCSGTQKYVHESCLIQWFATKSQTPISCEICQYKYRYKASAQYFPSSIFRFLILSVFWIFNIFLSSFTIKEIFLSSYTHILTSDSTFLYIFKQICSDKYKIDFKYLERNENTSAFVLNTLPGILITVISYLLFLFYHRISKCYTKYVLDRLYPPVLNTEYAMKKIRILQENKQGSCLEGAVSLCSNDNSITDIFNDIAFNESLYSKDGDFSGLNKIGAEDSDKISSIFSETKNRNARDKIMVSRKEDEFKRNIFDSKILETDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK4</accession>
    <name>A0A4Q9LUK4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1280p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001280">
        <property type="protein sequence ID" value="TBU11295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1280p0040"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="222" mass="24843" checksum="547533B5C96D29EC" modified="2019-07-31" version="1">MSDILWLTITLILLFYILLRNRIFSGSSSSSSRRDSSSRRDSSSKKYNTNKDTNKGTNRDTNKDTNKDNTNNNNTNNKDTNNTNNTNNTNNNTSDELVVQILVRSDLGMSKGKILSQVMHGISLLLRNNNSLEIWESKGEAKIVLKGDKNDFNTVIERCKSRGVKYYRVYDAGRTQVASGSNTVLVIGPLEKREAALITGSLKSIRLEKREAALITGSLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU6</accession>
    <name>A0A4Q9LUU6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0327p0020</name>
        <name evidence="11" type="ORF">CWI38_0756p0020</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000756">
        <property type="protein sequence ID" value="TBU12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000327">
        <property type="protein sequence ID" value="TBU14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0327p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0756p0020"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="449" mass="49648" checksum="6ED4C649B693EB03" modified="2019-07-31" version="1">MNDYIKKAMSLQATINIGTIGHVAHGKSTLVRAISGIHTIKFKSELERNITIKLGYANAKIYECNCTLCPRPGKYKAFPSSSPDSMPCYRRGCKGTLNLIRHVSFVDCPGHDVLMATMLNGTAIMDLAILLVAGNESCPQEQTQEHLFAVEIMNLSRIIVVQNKIDLISREQALEQYEQIKDFIDSTKIKQGPIIPASGQLNINIDAVLDCIVNFPHPHRDLEADPRMVIIRSFDVNRPGCLIENLKGGVIGGSLVTGKIKVGDNIEIRPGLISRIGSKIICRPFITKITSLKADNNELIEAIPGGLIGVMTEMDPTYCRADKLVGQVMGIKGKLPEIYVEIEVEYKLFQKILSTQKEIAPLNTEEQVLLNIGSTTTGGYILEIDENTCKFSLMRPCCCAKEERIAISRKIQNHWRLIGWGKILGGKWIEPVYDGSSEGNSDPVIDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK3</accession>
    <name>A0A4Q9LVK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0397p0010</name>
        <name evidence="3" type="ORF">CWI38_0689p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000397">
        <property type="protein sequence ID" value="TBU02887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000689">
        <property type="protein sequence ID" value="TBU12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0397p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0689p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="149" mass="16351" checksum="B1950FB5DE523CE6" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM8</accession>
    <name>A0A4Q9LVM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0641p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000641">
        <property type="protein sequence ID" value="TBU12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0641p0040"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="20903" checksum="7C761BAC84E613F0" modified="2019-07-31" version="1">MKATFNIKITHSKELTCLSNMSVKTEEINENFKTVFFNQKPKMSTYLVAFAIGNLEFIETESKNGDENNSAIQTKKRVAETVYHELAHQWFGNLRINRLGCLDIFFSEDVEASMSYDSLQSKNAIVVPVFNPNDINQIFDGISYFKGASLIRMLENYVGRENFKNAIQNYLEKILISKCNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR3</accession>
    <name>A0A4Q9LVR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0666p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000666">
        <property type="protein sequence ID" value="TBU12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0666p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="66" mass="7614" checksum="9967BF0D1F004460" modified="2019-07-31" version="1">MGVIIRAEMHEEPTPPLKEEKREEDGAKNLKPKNNIPFISQPTNNINEELDLEEETEVVKEVEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW39</accession>
    <name>A0A4Q9LW39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0577p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000577">
        <property type="protein sequence ID" value="TBU12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0577p0040"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="38336" checksum="4BF327D3AADAA017" modified="2019-07-31" version="1" fragment="single">ISIIANRQCKMYVTYKKIFVFLFLFGFIYLILFKYIFIFMNKDYFGDKLINIYSLVKNYVTDQSVHRFMDLIKIHSSQISKIIQNSVVLQPMGILFAFLLIPSSNIFYFEHQMVKKELAMAKYSIGSYYIATFLSEFFFYFPYCFAIQILSGLFFSKKLGWGFHIFLIFGLYAYLPVFLFFGSFIKRTGMRYLIISFLALFWITPPFMYSILRNLYTKKQNLFGLVFLVISALFPPLHYNAFCVALAYKTDSYKSRFLEKNPSVKELSDRFAEYLYSYLFDSMNIWYIVLFFFITSTIYIYFTIYALKKLLTPEHRFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW50</accession>
    <name>A0A4Q9LW50_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0735p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000735">
        <property type="protein sequence ID" value="TBU12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW50"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0735p0040"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="29496" checksum="D23EC24672C27586" modified="2019-07-31" version="1">MYDKTVQKLNKMQNEIIKELEKLEKLQYNTQNINMLNNLILNFNNFLLKSEPFFSSLDENENIKRKNMYRNYKSQIESFNQQIKEINDNYVIQQHLEEDTYVCDESVTDFEENEIFYAENVNKKINLNNEINSSIKINNFEDQEISTYDTNTNSYIKINNFEDKNISTGNTRRLNSYIETALDSLESLKKQRVYIDNTKSKIREGLIGLGLSSQVVDDISNRYLNDYYFFWVGVGIVVLIFLLFRFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG5</accession>
    <name>A0A4Q9LWG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0683p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000683">
        <property type="protein sequence ID" value="TBU12646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0683p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19583" checksum="42589199D03F89A4" modified="2019-07-31" version="1">MKSVKDLIKFWENIANPKKDQSSNVSTLKVVDEHWKLNDTKPANHCNNEPRFIVKNEARQRICLGLPFKEGMDNDFHKIKEAPVYVAMVQANVYDNCGDEKCGNDSKKIFKNDSKNDIVNYLDNSSSILSTKSIKKQVKNEKSNVQKNKRKKRWEGISDPKERLSHLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH7</accession>
    <name>A0A4Q9LWH7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0560p0050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000560">
        <property type="protein sequence ID" value="TBU13014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0560p0050"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="10">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27198" checksum="B76F6E4479EC9BEF" modified="2019-07-31" version="1">MRLETKNSEITVWLVKVPNFLAERLHELEGDIDIGELEITSATENEPASVNIKFSEKVCGSGFPTSFHLDRSEVDKQMYMLKSEKDTSGIEGKVTTECFVRPVINEEYILYRKPRNEITSGPKRMTQVIDFNKDGRIGERIGSISELETMARKRKKMLMDKKRERLDKSHVMDMLFNAFEKHKFWTVKDLADFTGQPVAYIQELISEIGMLNKKDHKNTYELKPEYSYGRDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX61</accession>
    <name>A0A4Q9LX61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0456p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000456">
        <property type="protein sequence ID" value="TBU13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0456p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="571" mass="66985" checksum="AC647567058C2C5E" modified="2019-07-31" version="1">MNFFYIFFIHVLATDRRYSGLLQDPTVVDNSYIELSIADYATPSIKNYIVVGISKDIGENRLKEINLVIDSYMYYIREYIIEPSIHEFLEKFTILVCIIIYGSDTETLIKFRVELLTNIIAFGRFVEMYRKESELGSIVKPLIKSFLINGFESLANTSKSYNKDMEEMSVIFNRVYEDIMNSNIKDFSEEIIELENVELSFDRIPETISNVQKNFNDASFERLFSFWLSVKYAYLAKNIFTLDDHQESKNKKFSLFLDNKFLNKISERDTRWQDSFYTKITPDLFQNMIKYIASPVIKKILTDEDKFQDILNFELNKNSSETVLPVDENFPTEFTNLFIEKSKSNQLIVIYNLLISVSKEEYHKCISAVICLKVLCFEKALSDNEVILRIIIEFLFFVDILNTEFEKQKYTEQMNFLSEEFKGVFDLSKLPSDLENQENDNELFLIETVAPKILNLIEMLVLINTFGDDVFLDKLDKCIIKVLNKTNNEQFELKSILDKQKEYVSFVFEEECKRYISSKSQNKQQENKNNKSKEENTSNFASKKNMFIILSILLLLAICGLCGYLLLRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX94</accession>
    <name>A0A4Q9LX94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0444p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000444">
        <property type="protein sequence ID" value="TBU13399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0444p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="45026" checksum="BEA9784D9D427A09" modified="2019-07-31" version="1">MNILNEKEISDLDENLIGLNFSDPYFISLLNEIKGGKENETTLTSKEEKIKSIQESIKDEEFKKFLLEVVLCRVFVGGFHLLKCKNESISSSVSKINEECLNIEIKNNEFFKILRKYYLKNRWELPKFYNYSISELCEDLKNKLVYTLSHFVFEKYSNENFANAFRRHNLTCIIDCKNLHAQLVIQNNINCIFPSDLEWTQQQSEYLKSFCFQLQCRTLYLSFNLSIENWIVVFFDQLFSKLKKYKFFRLIRTIFFGSKTEQEEKLREILKETPELELFQNEIKNFLVKLKNIIKSSTHALFNIYKIEDSVFKDIFSEFAKKYGLEDSILHDNDPSDYIAELKQTVVLCFSYFFESTLNKYFGIDEKVIMKRTLIFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX98</accession>
    <name>A0A4Q9LX98_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0577p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000577">
        <property type="protein sequence ID" value="TBU12947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0577p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="368" mass="42217" checksum="9ABE08D671F19649" modified="2019-07-31" version="1">MMALIVQKYHGIPKAYVKEYVKDCEVCRLLNSSKTIQPLINKTSELVKDSLKLLFNNFGVPVAIQSDNGREFKNTLLEAFLTDLNIKIIHGRPRNPKRKDTDGRTWIEHLNNVVYAYNRTIPTKENAAKHNGSTTTIIANDLEIDSKIRSDRLLNLFYDFSVFTVTAILMNNMIEVKNNDGTQEQFLETIRNNRPNIFILDEKKYKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYRLQIPMNVAHNLSIVLKKTVETISFDRRRGLESGLNAEKSWEKASMGVIMRAEMHEEPTPFLKEEKREEDGAKNFKPKNNTPLISQGGTTLEEPTNNINEKSDLEETEVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ7</accession>
    <name>A0A4Q9LXQ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyrimidine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0736p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000736">
        <property type="protein sequence ID" value="TBU12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0736p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020874626" description="Pyrimidine 5'-nucleotidase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="62801" checksum="41CA0F79DD84D9D0" modified="2019-07-31" version="1">MNGSFLFILYFLRIYTAAVNKEKTKRLYYDEIRSEMLNDPFVYYISMTCFCTLRKHNFLCKIIEEKLDLPYPPIYDQNLNDSFFAHYNLQHLFEYEKDIMKLFIFLRDEESKFNEHPCLQNMLKRYVQKNMTIDMKEYDKSFSERRNMEMKILKFDLEAYFEKENAVLASENDQDKTKINFLDKKCSISEDKKTHETENSTTFGSPLDGILICSKEQFDRQDFNKENLHPNSDSKSYQPSVEINIAADQRDVQSLNPRAIDVETDGIQPDILNRIYKSDTKDEFSHYKKSNAYKRHKEMCKNEKLEPTDTIFSFFYKMHFLKYESQWKDLLSFIPTTSYMGYTNILAYLGDFIHCIDFQKEVTNETFFISIEDSVFPKMYLDEIVLVFDIDDTLFPTSYWTNKYPNFGMDESYESSDSILREIVDDNPKKEDICNSSNTKILVTEHIKYRNDLKKYLKKLPFKKICFTNAAKIHPEKTLKALDILESSNLYFYDDVDQNVQAAKDRGWNSFLVKDSLIEVLETSLSELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW6</accession>
    <name>A0A4Q9LXW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0497p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000497">
        <property type="protein sequence ID" value="TBU13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0497p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="247" mass="29851" checksum="9C45286855BF1DCF" modified="2019-07-31" version="1">MSPKKERRIPRDIVSYRHLNIYDLFLKILADICLAVIEIFIPMYLYKIIYGLRAIDSNKIIFKYFILLLLFNCSFVFTLYSKSFESKHDLYYMIIFSFGFFSILAELFIHNLNITIIYELVWPFALLYVIFCFGNYFSICIKFNSCKFIRKEIPIITFIGYFYYLFIFILIDSFIYKFFLINIKILFVLKSIAYGIGMILCYVYLIRKNKFKVTLLLLLYHFTFLCAMEMNTLHYLYLYYNPLTDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY00</accession>
    <name>A0A4Q9LY00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0356p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000356">
        <property type="protein sequence ID" value="TBU13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0356p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="244" mass="29560" checksum="67407FD1A919E819" modified="2019-07-31" version="1">MNLKKNDLDENQSDKNKEKERFLKEYFEKELWKKPYNETENEDVSRDFGGKYSNGNISKEDLLENKKRQKIRNEAVKIISENQEEDLNEYKIKTEQKEKEGNKNVSKKSKKFHKESEEGNKRKLKVKINSLVDKLNRMFYLKEKYKKYLVFFEDKKREKIFEKIKKLSKKIKNTSKINSEDRFDCQKLINKIRLKFLEYFSENEVEFKYNETEKIDYGISLSEILYGDEDKLKAIYKKNSKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB2</accession>
    <name>A0A4Q9LYB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0323p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="43424" checksum="43CC1396D6B2A1E2" modified="2019-07-31" version="1">MNLPCTFKSENVHIYKNFEYKYLNWEITGIFIRKHFFEAKMDSNSLIDLNIYLYKVDFVNIFFKNKYIYNNIKILEISNSNIAYNSLKFLLLFPNLKKLKITNNNILYSEVNNIFETNMSIVSFEFEGIQMPSLKNFLQFIKSMKNLKNLSIKYQFGRNTLAFSEIEEFFRSEIDYFSFISCEDIHMGVFLLSVFSVKHNIELTSSCELGNLKANFSYDGFKNIRSIKISSIKIDETAINVFENLRRLERIELQPSEHLPIHFYKLFSSSCIYNLKVVILRGMKIVNIDIIFFSKSKNLEILEFNECHFNNISYIYFAKTKLIYLKLLEFLSYDCRFSKDFYDFLNEEYSENILHFEMNEIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM4</accession>
    <name>A0A4Q9LYM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0445p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000445">
        <property type="protein sequence ID" value="TBU13397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0445p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="20538" checksum="1A2651922C64F91B" modified="2019-07-31" version="1">MLFNQQVNRVLCKLDQNRINNNIVVTTYSLAERTLIQPSILPEFDNDNSLRILNLESSNIQKIHNNQKAKAGIDNRITTDAESWNNKPDDIVKKYHKTFLKRLQISYGCRGIHLIDSVYNDFGQFLFIDEENLSGNKSRRAPGKSLGKGIKKLEIHEEPTSSSKTRDTPGILRLTNGNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN7</accession>
    <name>A0A4Q9LYN7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0440p0020</name>
        <name evidence="1" type="ORF">CWI38_1476p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001476">
        <property type="protein sequence ID" value="TBU10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000440">
        <property type="protein sequence ID" value="TBU13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0440p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1476p0020"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14842" checksum="9E02BBABAF670CBC" modified="2019-07-31" version="1">MEDTVREKYNYFVSNQKLNKDTFKDLVRLCGYAPTEEQLNIDVPETFEEFEKLLVSFEKKYTKEDLYNELRALGDDEYISTDELRKLLTSGNDKLTEEEIRSFFKAVETNGNEVSIRDIVDLLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT4</accession>
    <name>A0A4Q9LYT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0292p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000292">
        <property type="protein sequence ID" value="TBU17001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0292p0010"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU17001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="292" mass="33393" checksum="FA3771F1CC3FC928" modified="2019-07-31" version="1" fragment="single">MKIKIALIVGYVGTEYNGLQYNIYGRTIEGEIIKSLLSIKAITEMNAAVPRKIALHRSCRTDKGVHAVMNIIVCKVVYKIENEKFEELKNDLLSKNIYLYKIVRVTKGFDAKKMCQARTYKYILPAFILKEGNFNEEIESFLVHCRSQKNILNLESNNSTLEPNLNQKCVLDNEGYEKKTLDASYSKNNRINELSLFEDSLSNDTNSSNFLEEKNVQFQTEIAKDNALITDSSQNKLKNEILNINTANTSSEKRFKEIVIENKDNISAQEDEIFGIGSLEEKSIQTNEKFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ13</accession>
    <name>A0A4Q9LZ13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0247p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000247">
        <property type="protein sequence ID" value="TBU18236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0247p0020"/>
    <dbReference type="OrthoDB" id="2194086at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="330" mass="38778" checksum="BCDB1B9010050C4C" modified="2019-07-31" version="1">MHVSVPIFIENEQSSISFTSTFLIFEPQNIKISFTSIKSLHTKDSTDFYCLKISSDESYTLKFTNLHIRDFFKNLIMMNVINEKKIKSDILKSGCKGEYEIVSKYFGEDTYWQMRGKMVNEYLQNYKSENNVGSVVSMLADNEILYSCYVKMNVTLNQFNNIYKQSYFFDVRNDKNSVDRIISEILAQNEMNFSSRLNSKSVMEIGDVHELVVEEKNLEEKIVDFEPIYPFNDESTSIENQISNEFSFPKTVNLKCNLNLKIDEDKPKVSLDSKEHKELIEMCRVAFFWGENQEIRSKIIEISDEFIKRVKEKYGTEKYFVTLIPKNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZF4</accession>
    <name>A0A4Q9LZF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0230p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000230">
        <property type="protein sequence ID" value="TBU18738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0230p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13301" checksum="502B1637E39FC12F" modified="2019-07-31" version="1">MLNGYKYFALRDQYHRPGEVTEFTEEESPIEYNLEFNQESNLIPIYCNAIQQATIFSPKRVDTNYRDIYIARIAKDADVHYNRIAFNSGDVVFIRRFFDTNRSPRSDKINSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR0</accession>
    <name>A0A4Q9LZR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0867p0010</name>
        <name evidence="4" type="ORF">CWI38_0299p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000867">
        <property type="protein sequence ID" value="TBU00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000299">
        <property type="protein sequence ID" value="TBU16188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0867p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0299p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445363" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU16188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="158" mass="16700" checksum="84E43A5980CCAE02" modified="2019-07-31" version="1">MEIFYKIIALAFFLLNKIDTAVVETGTATPVVTSADTATAIPTATATPTAVSEKKEESTANPEGLSANPTTAQIGNTLDGKNAIKEGNSTTSKNATLGSNETCPENNGTSHDSSKKKNEKSNHHNDSADTNGKNDRSSKDDKNVQRATFKRAELTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR4</accession>
    <name>A0A4Q9LZR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0487p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000487">
        <property type="protein sequence ID" value="TBU13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0487p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="538" mass="62904" checksum="0525E3B16547C649" modified="2019-07-31" version="1">MNFLYLMILFDYMVFGSKKNAKKNKNSIRISSCDRKTEEKAQHLHSIAIYIKGYKSLPLRIKNLKEMNYIAKLYSKNYVSKILSEENLKNNIFPKLVSKINEYDHSIFEKNNRKIYILCCFEIHNILREKMTLVFHSKFDSVTNLFFDKIFESIKNIKVSTLDEMETKMSNANFSKIEYCIGKIKILTKESEFTKSFILNLNEISSAESNFIKGYVFNILFKILSIILLNCEDYQITSTFLEKKDSTALNLALDSNDQIIFTKGKIDAKFLEDGRDNAVIFNEIGRLIIESSKFLTKEMTDLDFSEKTRQNLIFNGLDSCNIFELNPEDAIESVRKKISVFLKSNILRKLKISNEISPKTKIYLVIDLNKQIIQCSEFFLLYLHGLKSSLDRSKIFEELNDLNSIRNILSENNSLIFKYIQVILNVFHLILEEIDKKFNSSYEICLLFEDLASIDLEHIIKQHISNNMPRNPDSEKPYIQSFCDKKIKNVKSSLISIFILLLRDYFEIKFCNRSPKLSLKIENFSNEMSLEESLKVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR5</accession>
    <name>A0A4Q9LZR5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0030p0040</name>
        <name evidence="10" type="ORF">CWI38_0190p0030</name>
        <name evidence="9" type="ORF">CWI38_1478p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000030">
        <property type="protein sequence ID" value="TBU05251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001478">
        <property type="protein sequence ID" value="TBU10915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000190">
        <property type="protein sequence ID" value="TBU19834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0030p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0190p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1478p0020"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000011">
        <property type="entry name" value="50S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="7">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU05251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="343" mass="38337" checksum="732E5503852257FF" modified="2019-07-31" version="1">MLKKVECYGLDGTTVVKSLNVPKVFSTPIRKDLVHLVFKNQNLNGRTPYAVSKKAGMQHSAESWGTGRALARVARVRGSGTRRAGQGACANSCRGGRRASPTTVNRRWNRKTNLMARRHALSVGIAGSAVTGLVESRGHRVSKLKSLPLVVSNDIYKLRETKDALEMLKEFGLDEDVEKVKENISIRAGKGKMRNRRYIKKKGILIVGGNKKEFFKAFRNICGVECVTLDNLNIKNVCPGGHIGRLILWVEDAFEMLSKVFGEGELSSLRKGYSLMKNVVTDEDLEGIFYSDEVQAILKEPNFIKESKVVRDKNAIMSLNPYLDFFRKEEAKEVGFHDKLTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV6</accession>
    <name>A0A4Q9LZV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0183p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000183">
        <property type="protein sequence ID" value="TBU19870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0183p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="980" mass="116558" checksum="8F7B7A238C50C5D5" modified="2019-07-31" version="1" fragment="single">MSFEEVHIKLIVRVEILLNTKLNTINIFQSNNPKGKKDNQAYLALIKIFKIKYGLEKDLVSVNESLRSLLKESVRIFEKNSSDRRRGHDNRQDNNKQANNKPEILTQNTILIHFYEALDNSLRVNNSDTSHIYESEKYLTSDFFSNRKILRTKIIDLNIFLLEFLIEEQINQYEIYIYNEYLSYESFNYFYYVVMSFPCSIDNMNRNNYLLILKILNIFKFKINEPFLYLIRLVLVSLVLNPLAFKRSKQISFIETEYKFKSFISKMVICELFKLYMITEKTRSKLKNISEAVILTKNFKFEFINLNEDFLYLDLEIIEEILLILQNYKKFDEILNFILCVNRFRCLFLSYISYTAELESLFTLTLFQNIDEIFFFRCSDTDLLVEKIHQNFDFRNIKILNIIQSKFTIKDEISFLKTLNVGELNYILRTDGLISYFHNSDSNSPINNIFSTFIEEIYNDVNMFNIFVGNTNMPIYDEEKGISLELYQDKTKIEMLRNLEFQYQTFAYMELFHCYLAISFYIINSSKFKNIKLEFTDTDVKDFCLRESEVFNNITEIRITHSKIYENFLANILLFSSLKTLIMTRCTIILSKNEINFTENSKIKAIHLKNILADDQDHFSQFLSNMIALESLVLICFSGDINPFLAKCNQKMPKLNSLTALDCSVCFNPGDDIPDFSILSHLYTFDFGFGYPEGTLHKIFYERNFKDMRFLNLDGIKIGREDMYALEKYTNLRCLRFFNSCKISELAFSQLFDSNKIYFLEELQIQEIEFSDIDIFFISKLRLLKKLYIHSFILKTKIFNFLEIFYYVKEIELARISFSKNIIYEELGTRLIKPRDEAVFCYIQDRNVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW2</accession>
    <name>A0A4Q9LZW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0460p0070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0070"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="101"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="253"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="695" mass="81354" checksum="C552931622892CBA" modified="2019-07-31" version="1">MKEKERYLMEELKNQENNFLGIKSICSNKVDRVEEISRLKIEMNRLGIFLKNNQGLNDFSIDDIQNKIKEIEEYYVSDEEINNLQNKINEFKSKIAYPIIEGVFGILEENFSIIDKKYEEAIYSSMGSRSKFLVVKNEKIGNELLSSNNSSISIIPLNKIKPKIVPGDILRNVRQLGGIPITELINFDEEVSKAMEFVFNGYFLFENKENARKACYDYKVIGVTLDGTLYDPKGTLCGGKIICKNIIFRRKDLLELEQNFKEKKENKRIYENEKYNLNELKSKICNLREIKKAKNDIQIIENSIKFLNKLIESKVDYSSELSSLRQNIVKKIREKEEFLRRKNVLETEIFELKNKIKSKKEDEKNILKKILQLEGFRRQSEIKISKKSIGEREEESLELKRKHLLQNILKSKSKISKLRELLKEFKSGKNENSKSHLPVQIQEISDVLDDFKLSSNIFNVDLKIFDVKKEDELKKELFSVRKEIEMSKNIKKFRMDPRNFDLLEKNDEIIKELQEKIKKLENDKMRINKSINQLHELSIKEIERAFNHINNKIGTFINFFIKDADARIIKNEDEYLLKVKMGNWKDSLVELSGGQRSLMALSLIFSMLTYKTAPFYIFDEVDSALDLSHTQAIGEIIKKEFKNSQFIAISLKDGMYSNANNIYRGTTLEEPTINITEKSDLEEETTVVKKVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ6</accession>
    <name>A0A4Q9LZZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0460p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="12362" checksum="C5A9803197714F8B" modified="2019-07-31" version="1">MCTFNYMSLSDIFHNDFQSRIKHLDFRECLITLRDILWLNSLNFLAGMIFMYCRFEDVALISFKRKEFTYLHSLQLNFESLQSDYEIINCLNEEFGDVIMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M044</accession>
    <name>A0A4Q9M044_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0289p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000289">
        <property type="protein sequence ID" value="TBU17014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M044"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0289p0020"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="40271" checksum="39C0CB391C15115A" modified="2019-07-31" version="1">MKKLALISISMEIRQEENRERQNIECKVSRLVISTYLFEKSRMQGKPITSETPSLKPPMSIKDFSGALLKRIGVSLSTEKYNYECRKHSEKRIIWLGYFDAEFIIEKVILEEGLFSFLFAISMGGFSRKLNEKCVKVLIFKYQKQTSISQLFDYLKKDKDTSRRRAKILKIENNDRIHLALIKNFLKVKCGLKEEVTNINDEIAKLKPHSKLVMKGSFGLFDEAVRCYIYNKCIFGCRNVCQRCNQSRKTVDYLSTRYQKRHEHDYKCINLFPINRYEFLFSNRIRSHYVPEILDDKYIEIQSDIFNLNKRQDKIDLIEVGKNSQDSLQITYDLLANDLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H2</accession>
    <name>A0A4Q9M0H2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0136p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0020"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1126" mass="135819" checksum="22C2A034F223EB5C" modified="2019-07-31" version="1">MLRRQLECIKQKRKTSEIRSKPFITFKDVTDMDDETLLEQIPIETEFTTYKSLGYNRQHNTLEEENFICQKLSQFIKSLHHKMNIENIEYLFDFLIRKYCIDTFNSRDLVFLLLPYQKYYDKVVKLSEKFHTIDSFIHQNTYSLVFFGHECLRNIDFFDFFITYFEFYDVLKNFIDGVYFEILKSNICIKNYHALRLFESLKFFASYGEIEISKEIFKKFSKELLPFKCKIEIIFSNWENKFNKIADEEEKTNFATKNGLNNIKNNFGKTEEFDDSKSQNIFNENEISEKEIKGLKNEESIEFELYLVNKKDREFVYNLKKLIKYFEWIYEHENYGIEDTSYNNDEYNFCLYLFSKENIYSELKISDLRNIEDLFKHMKDKIFVIRKLLTKFSYKNLEFLIKYLKKDELIVFVSMCDDANEIINLMTNENHEDILKKMRRTIFVKNLVSVFKKSLEFENFSIIYFEDYITNLCIKECLDFSRNDIFSYNLLNLCKEKKISIVHEILELDFINELFLEYVLYNEEDLSLDSKKRIFEIYKNRSHNKKLQTAFNFFILKETNIEFLNQILNWFIDMEFEITSIIEILRKNLYLINSNTLLKLLKINKFRKDILFVTEKLIHENSENILLLLETKNIKIAKEIISKMNLKNFLESLSITFFFKNFDFIKDLIIEKSRKEDTLFFLKRSFEIYKNKELVIYKENISNIFLNEKYLNKNLIYFIETENWEFIKPLVVQGIKIHKEIVDLHFDYLIFEYGIINTETYYLLLLLNNLMEPKNLELNVLHKILEKNDINCLLTAHFIFLLGLKHNLDILSILNKIIDKIVFIEENDKIVFWLINRYRNVLAPHLQLFISLVYKDTEFHEYLILLNYKIVIREIVRMKELSNDTDFISLFTKYLKNITIDDHKTVISMIDFLKNRNEPFCCDLNTYFLISVSEIVNEETKLIIQKFVQEMYEYDVYHFYGIMDHVIVNDKCFWYFDPFYEESLESLKNNQLYVTNALSNYLKYAKSIALEYNEILNILSVYFDRNYDECVINCIVSILNHARNTTISLDFNLSILKKLKSTQNLKYIKILGFLYKNVINYNECINQSIPYFSIIINRGSDEIKSKMDELFVVIENLTGKTIYSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S7</accession>
    <name>A0A4Q9M0S7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0378p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000378">
        <property type="protein sequence ID" value="TBU13625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0S7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0378p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="688"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117431" checksum="3ACDECB9E4F73AC6" modified="2019-07-31" version="1">MPKHTRDAQTLSVLYALASKKITLLEKRVEKLEEEEKRYKKTLMLAKTNSIALWVHFKGIEKLRKVPKRSPPVSLVRLEAGARDPQADPAASELVCNAAELTEKPLEQNLVVNEAKSQSFGPTLAARSALAKARSLVKQIVPVECGTGNTTLPPIATPRSIEKNLPEKTSVSASGKGFKDKNKELFESKATGNPASKPRAVKLQTAKKPSFDPQCEDVVQGKSPFVLNRFVLLYLVGVKVNKPAYLRAVLENGGLLVNANSVDKVKAIFTGFKGVKTFDNYLNKGSLEEIGERLSELKRRLSWVERFKDNPPVRRHRSVFAKTLETRGYKDGRKRLDVTVKSKIDPETVQAVSRKHLGEKKAVRICTESYTNLRLLTLNVNSFGSKREETLRYTRNSRNVIPGYEVFESFAKKEEKDGRGLILAVRRKLDLTLSSFKLLVVNVYIPPKCSLYGNRAKTLEALGSFLVSENKKNGLDDILVMGDWNMTPEEAARFLAVNNLYCTNKWLFEAPRATRAAAHVEVQRKWDISDHLPVTVDFVEQSLAEKLISCPTWNSFGHNTDLGIYVAETVKEVVKKLGLEGTFSDGNKPAELIRTPMLSSNETENKVGAKRYCGGNKPLHERRVAVDEENHLIAVQEVISALHKSASNKACGIDEVVERRMRLYVENNNLLCREQAGFRTREECVAQVATLLEIQRRRFIRGDKTTSLFPYNIGLRQGCPLSPLLFDLFIDEIFRGVNGITCEGLNYRVPGLLFADETVLFGDDVAACNTWGTRINIDKCRLLLPPGLTGNVRIGEKAVPVVETYRYLGIVLNRTFSLKEMLNGRKKAVFAVRKMLCHSSEGQNKVRIVSVGCGCENQPSYEKAAMSRVRGFLKSQESRTIIRDLLNGKFTAGRERELLKTESGRKLILETIVKRQDRADKSVIGGLLDISGYKWIYAELNNRVLARSMRILRRFRIGLVKFSPQLAALGSLPIRYRERCLCCEEPVRETVSHLVFVYKRWKVTRRVVKCLKSFDAVGNLGLKASKQRIVIPEDLQSVNIPNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M149</accession>
    <name>A0A4Q9M149_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0326p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="PITK01000326">
        <property type="protein sequence ID" value="TBU14426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M149"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M149"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0326p0030"/>
    <dbReference type="OrthoDB" id="2196211at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="38"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU14426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="36055" checksum="D64DFA6AF6FB7A1D" modified="2019-07-31" version="1">MLDIRIKCEKSLLENLDLEENGYVQINGKNNYLLEKLQDLKAVRLSSGGTSLNTFIFLSKKGNIPLYFIGSVGSDKYLKILENELDILNIKYSFEIFDNNRTAKCFVLLNGRQRSLVTDLGASTCLSLKYVDTCLCNLPKNVFFYMSGFMIAAHLELSFHILDILKKNQLILNLSSYTLFSGSEYFFIKKYFDISNVVVGNFEEFYSFYKRVFDKEPINIRQILVELGYKNQTLICTDGGKDIYYTKNGKVYSSKIDKYLGDNVDTCGAGDAFAAGILYGFYNKYSIEEIIEIGKDWSEEYILENTKMIQELIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M188</accession>
    <name>A0A4Q9M188_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-dependent oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0284p0070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M188"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M188"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0070"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="703" mass="82302" checksum="906FCEE5FE2FEC38" modified="2019-07-31" version="1">MNTAQRRICLFLIISNEFCERFCYYGFRSLLFIFMRESYHFTTLKATWFMHLFNFMSYFFTFFGGILSDYVLGRYKTILYLTCVYLLGTLLVTYSAINLNLSYLIFGLILISFGTGGIKPSVSTFGGDQFKKEEKNKLERFFNIFYFWINAGSTLSMFYLPLLAKKRCFGRDTCYPLSFFIPSGLLLLSLVLFYSGSKFYIRHKPDSITLIRILRDIFPKIKFFKDKNIEKSFHTNENIKELNKEQLYNESNLKTQDNNIHEVDENLDKEDIKYSEAQINKSTEKNEQCKDEELQNLYIKNTKFLGVNQNLVKGEFMNLEVQKSNIFYYNEVSEDEKQYRKSQNQNIITQVSNENFENEGYNEFNFNIGHINQKDLPTFNDLTEPSKTEESEALNNETQLQEKKEIILDDNKSKVSFSFLKQKYGDKFARDIKKILNLLKVFSILPIFWMLYDQQTSSWVEQASKLSQDIKIFSYSYHLPPSQMQALNPILILVFIPLFTYVLYPLMYRYFKVTSIHKMSLGILFASLSFILASFISFYLNYSGSNFNLSNITLNDKIHNPIKSNSIINSNNSLRKDLHNNFKFNSSFNKETFKPPSILWQIPQYILITMGEILLSTTVLHFGYLHSPPSMRSLVLSLYLLTVALGNLYVMVFTTLEVVIFIRSKYAEGLISLFYAFIGIIGSFLLFKCKNSLENKSEVTEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M193</accession>
    <name>A0A4Q9M193_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0322p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000322">
        <property type="protein sequence ID" value="TBU14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M193"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0322p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10287" checksum="C04BB7C46E330714" modified="2019-07-31" version="1">MKITRTLIEIVKRSNIDADINIKTSEVFTTDLYDKEIILKDLVDKCNLLAMISNESGYKDRVMGKTIDRACLIANLDYALNKIAITYKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G0</accession>
    <name>A0A4Q9M1G0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0293p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000293">
        <property type="protein sequence ID" value="TBU16706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1G0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0293p0030"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="164"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU16706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="729" mass="85087" checksum="BFC0F3BCC007F95E" modified="2019-07-31" version="1">MNEIVELQENVIDNMCITIYCQQNKECKVISSPVDKNIIDIQKVKKFYFRFEIVSKNDCEDILYYEMTLYYKGTNQGFRSQYKKHFEMTILTDYDTDFKIEIVVHRKNECKIYFEKIHLNTNILEHESNGLLNSINDQTVKARFSWFPYYLNNFEPLKYIFPDRFFIGHRGSGTNQLKTEIEFYENTIPAFENAFKKGISWIEFDVQVTSDFIPIVFHDFMIKTNENEFYIGSLKFSEISKICQSKDSGYCNILGLDSLFTILDENIGFNIEMKYPNSEEIEENGIKETPNLILFIKSIFDVVERYPARKMFFSSFHMDTVIFIRLSYPNVILFYLTEGKESISSTNNDNPLEFAHNFCRRYNLKGVIVDSSVLLAFEHHLGRILNDDLLIFTYGSETNYDNTVTRLWESNITAMITDDIVTCKNRQEKEILTAYLKTGQYPAAYYKEEKRLCKQKAEYFTLLGDDISFKRRDHLIRAHAVAHIGANKMMALIAQKYYGIIKEYIKEYVKECEACIASHLECVNQTIKRWLAKKLHETGGIKWMEHLNNSVYAYNRTIHSTKNKSLFMLFFEQPGVKNPFSKSIIIENEASRIVPAIDIDPNIVLVEENAADTQWILEIASDVHEEFAKTVNTATIIIADDFGSDSKIFLDVAKHFKNFRERIIICLWRSSFDKKKDFDMNTKIIRAPSDSFYENSVFTVTASLMKNMIAVKNNDDDAITVFIGAIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H1</accession>
    <name>A0A4Q9M1H1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0162p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="49934" checksum="749B0551D396382C" modified="2019-07-31" version="1">MFKNDFLFECVTKVVQVEVERRGLLAEKQLGAVIGVQKAKEQALLCIVLNKEYENNLKATWIHNVEREILQGDSLSPFVCVVFSHHHHLLLLDHLKLFAKDSQTLEEMIRNKKRKSAIIDPCFEDTATPLEGIGVYKYIEIIEDSREILTRNSFDELDVAVRAVLMNNKIHHRSGCKESLYLPRIEIGRGFHSVKNNNKTHLPLIKSFLKKNLEEAQLAKLYNEIGKINFTESANKAVFCYIQERNVFWNAEDAYQHCNQSRKRVYHLAARCEKMLGRDYTRLHHKVFKSSNGSNSTGEGIIENEDAEIRVDIRIKTYLKILNNRPDIFILDMKKNKITIIDARFTSNITLKKTANTPNVEIYIQSISIPNAEESREERQLVFLLIWNTSETTLLFKRVDFEQYVVRHINEDSNLEEERVDVQEVEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M262</accession>
    <name>A0A4Q9M262_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0138p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000138">
        <property type="protein sequence ID" value="TBU20068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M262"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0138p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="111907" checksum="A04509ADFDA3A968" modified="2019-07-31" version="1">MQQEESCECIKKQKLDLENAQPCYKSDYTTENAHIKDIHYPECNINEKYRESSSLQNITNEDNGMMNTEDRGTILINQRKKLVIFDYLDTFMIRSKYLDELSMSENEELKLNINDITKSHIDSEIFEECMNTLQYGWCSIFYDLKKEQFLSLIRLLYDLDCYSDSNALFIFYENLLPFIFSYLADRSCINISNLTGVDFKSNTKYFLPFIYVLYDSIEINFNTNNKELTLIEREQDIKKITYEKHNIFEIIIRTTPRALDIIYDENSKDKWVFLNCIICSFKIEGIRISSNDMYFSECKNIDLKCESILHNSKIYEMNTAFISVFTTIELMKRSEIKSIEFEKVVLSDLDVLFLISLINIESLSIVKCTMTRSTFHFRKLARYFPKLKILRIVGFELQYGFFNRLPLTNIEVLDISCSRYIGNLNHLKSERMNSLIELGISYTYLNYKILNFLMLSNNLKVLTMRGVDSLRLRHFNECDNWQRSFQYLDLSRGKLHDFFLTFFSMNIKAEVLFLENLNRTGHLKKILEQKSLYESTKKLSLSGCFISEDLIDYICEFKFLEHLYLFCLKQEFLDLSFFKCKFISILVVLNLSKNELKKETLDSLKHFDRLETLNLSDCSLKPEFMSYLCVPSLIAFVAKLKLSGNIFCASDIFKIGFFINLVYLSITLDNKVFADYLTEYRVLRCMNLEKLVLVTTDLNIDIKNLILSLPSLRSVKLIRCKNTNENKYDFHVGETPECIECENDNVLKCLVEISGSHDENLPVTTIPTLRKQKVSINDRKRIIEKTLEGYSMSEIASVRYLKIGLVFVEKRGGDRRSKLTLEIKESLQTYGDLECKKTLYELAEWVKIHLMLMCQLRLTLGPEPRNTLSTIELRTNYANCFCELEVVKRPSRGRNGKEMNKYDMIYHNIHERAMNDEDFKLYIKEINESCQRQGILTPIFVMNNARIFTIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M277</accession>
    <name>A0A4Q9M277_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0015p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M277"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11767" checksum="5BE64AA807B81213" modified="2019-07-31" version="1">MENENFNQIYILLKNVKLIHINDSLRGFKNIRIRPGEEHCSAMFRIESILVSRRLYRVATNCSKIFGNDYTSWHNEEEIYENELRRLNFSKTLNQNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K9</accession>
    <name>A0A4Q9M2K9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0008p0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0220"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19176" checksum="9850C2C83B573B6C" modified="2019-07-31" version="1" fragment="single">KITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKFSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMSVIMRSEVHEEPIPPLKEEKREEDGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M6</accession>
    <name>A0A4Q9M2M6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0004p0060</name>
        <name evidence="1" type="ORF">CWI38_0006p0070</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU20999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="29598" checksum="95195ED10BFAE0E3" modified="2019-07-31" version="1">MILNATKAVRRFQINQKKNPILALLIFIMYKTHRNKLQEYFSKALDTLGIQFLAIKLNNIANFVKITYDSANKLFHTFCKQKTNLGSNVDDILREKMNNIVKNKKIEDLLDFCKIIQTFIRISFEFYLQIDNFKQEDAKNSVEKLISTVIDGMLLEHCKKENNFTQNHNKNDKFDPENINKDIALKFLKEKIIKNISPFKKDLINILKCFFMRFKFTTEEIFTDYNVIFAISDCLLRNAISSLEILQPIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Z1</accession>
    <name>A0A4Q9M2Z1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0139p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000139">
        <property type="protein sequence ID" value="TBU20062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Z1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0139p0050"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21274" checksum="4F6E658373E69926" modified="2019-07-31" version="1">MIVYHLAARCEKMQVLGYTRRHNEVFSKRIRSHSVQEILDNEYAEIRVDTRIKNDVKIRNNRPDIFILDKKKNKITLIEVGITFQDLLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYYKTYSEPNTEESWVRASMSVIMRAYMLTMLEEPTININEESDLEEETSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Z8</accession>
    <name>A0A4Q9M3Z8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0088p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Z8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="7037" checksum="1B89792B2A395D48" modified="2019-07-31" version="1">MFKIRDKIIYYLDSNQKRIKIQNLQANFFSIFKETDNECKIKKQSFIYVVTRNNTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M437</accession>
    <name>A0A4Q9M437_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0005p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M437"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="104292" checksum="2BF12031F993FB87" modified="2019-07-31" version="1">MNMKKNPYMSYKYGFLFYKREQTILEPIICLLDCKVILRRFFFALGLICFNKFSNCVRITISFPNEVVKEDIIIDFDKDMYSDEFFERNLSNESVKYMVDQNKVDSSSYHQNMVQIDERNKRCCVFSDKYNENKKKAKVNESSQPPETANPLFNDNFGNHKQGEAQNFTTEPPLELKSTVEVEHNKHNLQSNLKTARLIFQYSTDYIIRSEFLDDFLKYDSDDVNLVLKDISENIINMNVFKVLLITLRFGYHPGLMSLNRDQFLEFVILLTDLTVYSESGVLDSLYKNLFSFIFCFEPEFYQQLNSDSYHRNAIIYRKAFIPFLGVLFDSIEVFLDFERSELCFYKNTGIRVFNLLYTGQLNSSILRTTPEALNIIYQHDNMEKQKFLSWFLNFYKIEGIRISANNFFYTECKDPDMAYNFLQISDSPLGTFVYTNPNIFTIIMQNYKNDIKLIEFERIVLSENDIKTLILFDSLEILILVKCSFNIHSGFLEMLYIFFSRLKILKLIGFFLTSNFFNNLLLLKLVELDLSFSTFIGSPNDLKFETNSIQLTTFNMNGCSLPYIIIDSYLKSQLLKNLSMRNVDLTSLKSDFRIIQWQKSYRFLDISGCAFGNILDFFSSNLISESLILKNLKNRTEALKILKQESLYNSTKYLSYSGEYITDVFFNYFKMFRCLESIKIHETLTDTSLWQEYNLFFVCQLKSLDLSRNILSKNTLTKLPLFSNLEQLNISKCNLKNGFMGFLYNKKQFLSLKRLDISGNQLNISDILVLNQLLNLTHLKITLENNILSNYFKEYGTICFKKLESLVLVSTYFDETIFHFVISNISLLKLKLKFCKVFHSGLTKENIYKLKFFKKITFCQTLFHQEVLKILDLFKILRIYVIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M439</accession>
    <name>A0A4Q9M439_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_0093p0010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000093">
        <property type="protein sequence ID" value="TBU20296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M439"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M439"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0093p0010"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="246"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU20296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="48394" checksum="0771FA906E06F0DD" modified="2019-07-31" version="1">MREIISIHVGQAGVQIGNSCWELHCNEHGILPNGSIDPNPNQNDVGSSSSFFSETSSGNYVPRTVMVDLEPGVIDSIKNGPYKKLYHPSQLIHGKEDAANNYARGHYTVGKEIIEPVMEQVRKLADNCDGLQGFLIYHSFGGGTGSGFGALVMDRLSTEFGKKCKLEFCVYPAPRVSTAVVEPYNSILTTHTTLDHSDCSFLVDNEAIYDMCRNLGIERPMYGDLNRIIAQVVSSVTASLRFPGSLNVDLTEFQTNLVPYPRIHFPLAAYSPMLSKEKASHESLTVSEIAAACFEPQNQMVKCNPKNGKYMACCLLFRGDVKPKDANQAATLIKNKRINQFVEWCPTGFKIGINDRPPFILEGSFMAPVKRACCSLSNTTAISEAWKRLNHKFDLMFAKRAFVHWFVGEGMEEGEFSEAREDLAALEEDYMSVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4M3</accession>
    <name>A0A4Q9M4M3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0058p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000058">
        <property type="protein sequence ID" value="TBU20516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4M3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0058p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="749" mass="88738" checksum="AA9FA3ED9CE179CA" modified="2019-07-31" version="1">MLKLILAQETRAIHFYENCENISEKNSYTYSDVHLSIFVEDKKPHSFNSKNKISTTFMVELDYFFLKFPDFDAEKSEIPQQDIFIDNSILSYEDFSYFYKIVIEFPDFLNDMNPIKHHLIFKILSIFMFKKSKSLEKFISIIWTSILFNPISFKKLRHFSENIYEPHFPSYISKIVIVVIFRLFRISKYIRDKIGSVSRAEECTNYMQLEFIDMNENYLYIDNEIVNVILSVHKNTKIFLEVLNTIFVFHNFKRLFLCQVTYECGQKIFYSLSLFKCINELSLFRCSKIDLLIREIYETLDLECISMLNIIEGKFTIENEITFLKDLKFESLNYVAQDFGFISLNGHEDYIPLVKDIYSRFFDDIFNCENISNILVCKTLKPVYDTDKLLSLDLYQQTSWLENLRSVKLPLRTYVRGVMRNRYTMLDFHILNLYRLRSIKLQFYDLYFKDFCSYTSETCCNIREIEIQHSTIFFLFLSKILKFPSLTSLSFFECKFLASTEEIIFDENITIKTLTLGASSILEKHLFYDFFNKMKAIKTFNFHSRSAVEMISILSEYGDIFMDLLGLDCLEFLLYNSFCDTMHLFPSLPNLQKFYFGSDSSSGTLYKVFHNNDFSGLRVLRIIRANIGAADKNSLEKFTHLQSLIFCNNSYISEISFSELFNTTDLYSLEELGIPKIEFTHLEFIFFSKLKSLKKLYIEVLTNKITIMCLLKVFNTIKIIEIKQGLYKSHQIFEILSSRLKVENMCLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5T1</accession>
    <name>A0A4Q9M5T1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5T1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0140"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="81879" checksum="D7625E0C0601A8C2" modified="2019-07-31" version="1">MFPGNNATAMPRNGWSAILRYYNGKFGRTVDIVKIGQEENGKRREYAECNVPKKVSDAARIIQAVQVCYEEVGVKISKLVLSKDLLEKVRKQEKLSNSETKSPRKIMREFNLDLSQINDLWALVKKNKSLNVYEKKVTIYESRYYRGLSERVESEHVVNRDEISGFGLQCGAKMINSKTFPLLEEFINIINWLPNRKAAGLMPLLNVAIYKDYENNIKATWIDFTYLTQCMENRNLSDLILKFIEVIISKWKIDILVRPVKIMSKKNDRGILQIDSLSPVLFLLQNSVTNDLCCEATDTLLGEIDSRGIPTVKSYEEVQTKLIARVERLCRTRLNARNLFQVINQHAISLLNYHIGVLRLGPAEFSKLDDAVRAVLVKNKIHLRPGCKERLQLPRKELRRGLHSSNSKANICFQLLDCLKKHKDTSTRRAPILKLYSAKNNELVSVNDFLRWLKKGSVRPRDEAVFCYIQDINLFWGAEGMCQHCNQSRKTVDHLATRYDIIKGSHSVQEILHKEYSEIRVKTRIKTNVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYLCSVEIIPYVMTWDGIGTNTIRLLRKTFETISFDRRRGLESGQNAEESWEKALLKIILGAEMHKQPIHPLKQVDNEEDDVKTENTKNTLPLILDGITTVKEPMININEYSELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW94</accession>
    <name>A0A4V2JW94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2452p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002452">
        <property type="protein sequence ID" value="TBU07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2452p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22241" checksum="47AE22DB9E34137C" modified="2019-07-31" version="1">MCQHCNKSGKTADHLELDESLSSEILDNEVITDVKIRNNRPNIFILDKKKNKITLIEVGITSKDSLQIVETEKRRKYDLLVNELGLIYRCSVEIIPYVMTWDGIVKKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRALESGLNAEESWERASMGVIMRAEMHEEPIPPLKEEKREEDDAKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX21</accession>
    <name>A0A4V2JX21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2020p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002020">
        <property type="protein sequence ID" value="TBU10102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2020p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020481319" evidence="2">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="37156" checksum="7AA0F384BD9670A4" modified="2019-07-31" version="1">MFDVNKGFMILSCMFLGFYLDYVNTSWGGGRSSGWGGGWGGMGQGQMQSQSQMQGQGQMQGQRQGQMQGQRQGQMQGQRQGQMQGQGQMQGQRQGQMQGQGQMQGQGQMQGQGQMQGQRQGQMQGQRQGQMQGQGQMQGQGQMQGQKQMQGQRQGQMQGQEQGQGSAENPEKMQGIGSHKPDRQDPGKPETQNGTKKEANPMNKKEENLQGNENPQEAANSRQPKTGVESGADRQMQGQQQGQQQGQFQGQNQHQMQAQQQGQHQSQFQGQHQSQFQAQHQSQYQAQHQAQHQGQFQGQHQGQFQGQHQGQFQGQHQGQGQNMYGGGGGWGGGWGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX67</accession>
    <name>A0A4V2JX67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1627p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001627">
        <property type="protein sequence ID" value="TBU10652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1627p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15070" checksum="25E5963FB6160AC5" modified="2019-07-31" version="1">MIDKYFFTAFIEESLQKYTIKPLKDKKKYDIKLFCSSFLPKILSTKNISLKTNDKGTYIIITDVLPLYLEYKNNWSLIHSKMLKVSVSSNNEVLVLIDEVLVVINEVLVLIMRCVSIGIGFWRDGLEKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA9</accession>
    <name>A0A4V2JXA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1379p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001379">
        <property type="protein sequence ID" value="TBU11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1379p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11448" checksum="96B4B81FA073D869" modified="2019-07-31" version="1">MNEEKDELLDKMPEKVISYFYKTEILKDADELKECNQRLNELESFQIYKEIKNSEVKKKIESQDPALVKAYMEDLKNNKSTTRKNNKRGKKGMQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB9</accession>
    <name>A0A4V2JXB9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase</fullName>
            <shortName evidence="5">UDG</shortName>
            <ecNumber evidence="5">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNG1</name>
        <name evidence="8" type="ORF">CWI38_1354p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001354">
        <property type="protein sequence ID" value="TBU11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1354p0010"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="7">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="32016" checksum="A9EC6813874E1FC6" modified="2019-07-31" version="1">MTKELLNNSDEIDRKKNCSHTCKICKLKDYISEDWRKYFESESIDEILCSIIKRLHSTQFYPSIEDIFRFTYFFPLEETKVVIIGQDPYHNQGEATGLAFSVSETHKKLPPSLRNILKEVSSNFPNEVNINMRNTLNKYFKSKENKEKINHKINSSVDKPLNGCLIRWLQQNVLLLNSTLTVAPNKPNSHFGYNWHIITDNLINKISENCANVVFMLWGNYAIKKEILIDCKRHLILKSSHPSPFSADISFFGSMQFKKANEYLIQNNKKEIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD9</accession>
    <name>A0A4V2JXD9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1225p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001225">
        <property type="protein sequence ID" value="TBU11402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1225p0010"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="44952" checksum="EA399D67C1B6E7A5" modified="2019-07-31" version="1" fragment="single">MNSYYKKDLIKNKYSYPYFRINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRDLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF4</accession>
    <name>A0A4V2JXF4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1441p0020</name>
        <name evidence="3" type="ORF">CWI38_1154p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001441">
        <property type="protein sequence ID" value="TBT99157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001154">
        <property type="protein sequence ID" value="TBU11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1441p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1154p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033454013" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13014" checksum="E3445E472484ED1E" modified="2019-07-31" version="1">MLCFLIFLLFTNIFGKVAIPYSVEEVNTIDEDSSNTGKEIVQVINIETGAVLNNPESKQAVHVKRSPHCPGIFPRHIISNGYHEIDYAHTDDRGCSHQHGIYGRHMHGVHHLDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI1</accession>
    <name>A0A4V2JXI1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0984p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000984">
        <property type="protein sequence ID" value="TBU11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0984p0020"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="43037" checksum="05A60A1888BE6383" modified="2019-07-31" version="1">MGTGKTTEQSSEVEDSNCIEDTINEESDRESGEITIKEYENAEENIEPPYSPINDSASIVDEFQSKKFTEDFLPQTTILKNTPKNLAYSISDTSDYEFKKYRNQEMPSYSTGRRDIAYDRSRISKLDNLVNHADFELERKIKITRKYERRDRHEQFYSELPYERKEVETRRYSTRRIMSHQQPPPNPGENYRPKKTLLDYLFDQANYEMEQIKESKRRRKETASRYLQNTPEPIRPRRPELPLPRPSYPKQPSPRKYKKRLSLDEPEAETSSNETINSFADIDDNKFKVLIHGDKKDYICPELDCQKSFPSLSRAKRHFIVHTGAKPFKCLNPQCSKSFSRKDNMLQHYRSHCSLTKDQYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW9</accession>
    <name>A0A4V2JXW9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0421p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000421">
        <property type="protein sequence ID" value="TBU13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0421p0020"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23077" checksum="1BE796B5AD3AE836" modified="2019-07-31" version="1">MHLPNPIAFNKDGIVKKYEAIRFLGKGIEGSVFLVKDIQTKEKFALKVQPKKTHLTCNYIAELFKNYLRHENIVEFYGYYNDSNYEYLLFEYLPITLHTYLFRNKETFINFLFIMKQMLDVLNFLQAQKIVFRDFKFDNVMLTENLKIKAIDFGQAVFEENQSLVFYDEAIRNGLNEETRYLYISPEIRNGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY55</accession>
    <name>A0A4V2JY55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0499p0010</name>
        <name evidence="2" type="ORF">CWI38_0212p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000499">
        <property type="protein sequence ID" value="TBU02359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000212">
        <property type="protein sequence ID" value="TBU19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0499p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0212p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="581" mass="69780" checksum="D442D65B20C3571B" modified="2019-07-31" version="1">MFKFRYYISVSFLLYKCCHGANIYESFDTMDLLQPTCSHDVTETDIKNCESSNLRRSHKRKPHSDFIFGVSKSSKSLLRKTKINIHSPGVLGNYTTGIPLNYVFKDLDPLNICSLYLLSMYELKFDYQLDILKQSFKEKSSWRFSFEYLNIKDDPREVYENTDILNIRKCYLSINKLYRFFLLTDNDSFPLYNENIGISKISSQYSDNYFDKNVFEKINFEINREIINLYCNENEYVEFQSKIDYFVQTELNFKKNIKSKAILSSDMEYMYLNDFMKYWKDSIREIFKNKDNYIYIILPEFLSFEIKLLENLSKVSLAVGNYFLSIFYLKFLLLDPKIKLIKSQYMCNTYRKRICAFSNEECRFFLKNKILLKEKFLKLLEIFGFSVNINLLYSIFFLAEKIIYHNLIIRKFDSSYLSSYHILCIFNTVIFQMDENTIKNMLLNRSYLIEIVSIYQKNIYRKSTPVNSAKLNPLLEKNIILLITKVLKYLLDIQLSDHKVCWEKEKEKIFYEINCIEDATINMKKYVDLISRKNLKPRSFQISEIMILLLCLKYRIFKYKFGIEGYMNNLQYFQKYFLKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB6</accession>
    <name>A0A4V2JYB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0064p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000064">
        <property type="protein sequence ID" value="TBU20483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0064p0010"/>
    <dbReference type="OrthoDB" id="5371837at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="493" mass="54318" checksum="63AAB21F9E0FE871" modified="2019-07-31" version="1" fragment="single">EEVIKEIEGVNKDDEGIKGLEGIKGLEGVNKDDEGIKGLEGVNKDEEVIKEIEGVNKDDEGIKGLEGIKGLEGVNKDDEGIKGLEGVNKDEEVIKEIEGVNKDDEGIKGLEGVNKDEEVIKEIEGVNKDEEVIKGLEGIKGLEGVNKDEEVIKEIEGVNKEVPFRDKEIPFNNNTTEEIPFNNTTEEIPFGDNTFNNTSTVPIINTLCSSPSIKEALGNKSKDKGLNELKVDDITVIEGEDNKGCYNSNDILGNITPFNDETYNTGTSSNDNRLLDNSSNNTLLDSSSNNLLDNSSNTLLNNSSSNNTPSIDINTPLNNSTNYPYLISELLSGLSVFECTSLSLKRIITDVSVSNDNIRKNFIGCMMEVLNYYEEEFKVIIIENMLNNSNDWRYRVILMLKVIETMGIKGLSLVSKLEKDKVFYVRKVYEEIKEKYIGILIGDKGVLIIGILLGDKGVLIIGIHVTVFDSMDIGVGVKQLEILGGVIRTNVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KX66</accession>
    <name>A0A4Q9KX66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1319p0010</name>
        <name evidence="7" type="ORF">CWI38_1099p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001319">
        <property type="protein sequence ID" value="TBT99506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001099">
        <property type="protein sequence ID" value="TBU11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KX66"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KX66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1319p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1099p0020"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="5">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="4">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT99506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="228" mass="26829" checksum="D0E59327B30A1EAE" modified="2019-07-31" version="1">MIGIIDTSSLIKRNIKIMNYTKFYTTTSVINEIKDNETLAFYNLNSYKIEIMNPSTIYIERIEKINIEKQFKLSNTDVEVVALTLQLYEDNMQGWISIENVNTLESVVCLTEDKSMISALCACGVISDGFNVQRNYKIRCFTCYKIYDNDIDFCKKCGYNTLSRISFTETNEGIKFHFKKNFNYCVKDIKDKYGKPIKSADQRNYEIYKREQRKKEKENKKILSAQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYS2</accession>
    <name>A0A4Q9KYS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Rpb3/Rpb11-like subunit of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1092p0030</name>
        <name evidence="6" type="ORF">CWI38_0236p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001092">
        <property type="protein sequence ID" value="TBU00168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYS2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KYS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1092p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0020"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU00168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="106" mass="12169" checksum="4DBFC26AF6BBF7F2" modified="2019-07-31" version="1">MSQNTDQNPQKIKPLNNFTLSIHNEDHTLMNALRYTIQLCSPEVDIVGYTIPHPSEQISNLRIQYTEENDQNISNMAHTVKNGLTSLENIIVKIFDKISVFENQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L421</accession>
    <name>A0A4Q9L421_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0522p0010</name>
        <name evidence="3" type="ORF">CWI38_0021p0170</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000522">
        <property type="protein sequence ID" value="TBU02247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L421"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0522p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0170"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="247" mass="29265" checksum="8DEDD15B6B4E6B5C" modified="2019-07-31" version="1">MKDLEMQRNINSIKNEISLEKITSKYFFLVSILSFVIFNELAFLSKNIRLSYLFLPIFIINAIFFYKKVKKNYSLNEDNNKSEEYSVTVLRILKISIFTILTDIIFQVIFKLGYNSIYLFQIFMTIICAIQFVLSVFQGKLFSEVFPDKYIKKRKILDKMIIVFTFIYFILPICMVSRYSRIDLTIVNSLIGFFIGYLIGLNDKLEKENEFLFGKRFFSKIITFFYIVSTCVKIITTQWSTLDYVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4X9</accession>
    <name>A0A4Q9L4X9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NLI interacting factor-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0515p0030</name>
        <name evidence="4" type="ORF">CWI38_0508p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000515">
        <property type="protein sequence ID" value="TBU02286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000508">
        <property type="protein sequence ID" value="TBU13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4X9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4X9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0515p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0508p0020"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000093">
        <property type="entry name" value="NLI interacting factor-like phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="278"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="451" mass="51491" checksum="12844F3E3D9F76BA" modified="2019-07-31" version="1">MGFIRAVKNFFSCCNCSKKRSEANKIYPSDRKPASDKTKISSFSNSYESNDMESNMNNIRFDKPSDENSYNPCNNDCTNDTNGFTMTSIQPTYKKEVLDVPEQDLSTESSLKTEDIPNDSSVQEETNKQNELLPVKNDSDADLAFDEIEIISDTDETGFDEICFDFNIQENNLQSSATVDHQSIETTDSGKVKIFEEKVLFETKTEEIVAFSNESTILPSKLSVSDRISKFESNSIKIIQPHPKYTDKINICNEILINNRLSATDSFVNSVGLLLPQQRRKRPTLVIDLDDTLIFPSFIRLKSCDTVVSVLDGNKETLVYITIRPFLQEFIQSLKMKYELVLFTSAKESYARKVIGAITCLSEMDFYLFRDSCTFFNGVYVKDLSRLQRDLNKVLIVDNSPHSYMFQPENSIPIFSFQGARNDNELQKLEYFLSLISNKIDLIAAKKEFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8U9</accession>
    <name>A0A4Q9L8U9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0227p0010</name>
        <name evidence="3" type="ORF">CWI38_0481p0020</name>
        <name evidence="2" type="ORF">CWI38_1108p0010</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000227">
        <property type="protein sequence ID" value="TBU03816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001108">
        <property type="protein sequence ID" value="TBU11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000481">
        <property type="protein sequence ID" value="TBU13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8U9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0227p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0481p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1108p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="320" mass="38506" checksum="4138243CB73DE312" modified="2019-07-31" version="1">MKIYFIILILEHIHGTFLINKEIQKQKIINKCTASIMKDYRRNFFASNISFNLIFNCCDTQVEKLQKEIIIKYFEYFLAEFAIKSSFHLNDIIQKVKYAHSINIYKKNLYFILKNYILQNYPSSLVASEKALKDIFERSIPTVKLEKHIKDVLKENFEYINVKKETSPERKKTNLQNTQFKCSFSSFMENGCYFNILDLDFQLDRNIYIKNFYFDKKSEMYKIKDLIRQTSFLFCMDTSLIQAYSHIYFKCNFTFFRIRIYSVSSKNNYKEMLKPDLTQFKIFKKILSNVYERMVKDFFSENSKFNQGLMSISLNFFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9K0</accession>
    <name>A0A4Q9L9K0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative nucleoporin autopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0291p0010</name>
        <name evidence="11" type="ORF">CWI38_0469p0040</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000291">
        <property type="protein sequence ID" value="TBU03460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000469">
        <property type="protein sequence ID" value="TBU13321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9K0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0291p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0469p0040"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF19">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="9">
        <location>
            <begin position="382"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="523" mass="58284" checksum="57F5B16874316E97" modified="2019-07-31" version="1">MNPQNNSNSIYNTLLFSSTPKKDQRTETSSFGSTPWSQQISQPVSTIKGTKDTPYKKSSVRDTVTHFPIDILHICSMKEYSDKCIEEIRNEDYILGRKQQTSSSFQMPSIQPTFSSSTQTTSSLLPQQNFSSVLQQPAAPSFLSNQNTSSISQPAFNLNKPVSSTQLGSTPSFFSQPTTSQSSFSLTQPSFQTGIATGQPTGINSGISTGFPSNQPLGASSTTSNIFAKPQTTQPFQSSFLQNTTTAPSFTQPSFLQPSATAPSFTQPSFLQNSTTAPSYTQPSFLQSSTSAPNFTQNIPSQPSFGQQNMPQSLFPQNITNQPTQSNISVPSVNYADPYLVSDIRFEKAKRETDINRKKFLEPIFEIEDQMKEEKNEFSVFKDFKDLNNTIYTIPATEGLDLNVVISNLIIVFEKKGRIEYLEGIRAKDCRIENIKNKIFFSGKEVKISDNIGTGLNKRARVYVEGCYPYSRGTGGFIIGKKEEFPLKGVQERYIYGLKSDNFRKFVDYDCEKGIYSYEVAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9W8</accession>
    <name>A0A4Q9L9W8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDK-activating kinase assembly factor MAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0184p0050</name>
        <name evidence="7" type="ORF">CWI38_0134p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000184">
        <property type="protein sequence ID" value="TBU04095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9W8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9W8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0184p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0020"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU04095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="257" mass="30750" checksum="912218A6DE55AE21" modified="2019-07-31" version="1">MTELECPLCKSDSYLNPNIKIYVGPCYHKMCETCLTRIFVHGQAPCPECGILLRKVNFMYQTFEDIEVERECKIRKMLRREFYRREEDFKNEMEYNDYLEEFENVVMELMEYKNEQEISKRIEEFRSLYGEISRINSEKEKSEIIYEEEIPIILEESDEKSNKKQKIIDFQDEIVKSDKPCEQILKNVMKISTKKYRNLENEIITHFDPLEGIETLVSSLNKKCEIPTEFKVKYNGSGFSYNLIIFKSLNSLYNENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAH1</accession>
    <name>A0A4Q9LAH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0155p0030</name>
        <name evidence="3" type="ORF">CWI38_2607p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000155">
        <property type="protein sequence ID" value="TBU04305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002607">
        <property type="protein sequence ID" value="TBU06273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0155p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2607p0010"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="178" mass="21609" checksum="D55D6CE04227C86F" modified="2019-07-31" version="1">MTFEENEFTDWKYKGEVEGRERPKGSLLNQEIQFDQTKPLIPILEENFDIRKVVIERIKERKYDNWILQKKEENINEGIENNEENKDITNIEDDNLSKEEMRELFSLIDKQLLQITDYKLLFCNSLFYKEELIKNENEINFDKNVSESEKRRKESKKRSKESKDIKKLRKIRNVTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCB4</accession>
    <name>A0A4Q9LCB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0095p0020</name>
        <name evidence="9" type="ORF">CWI38_0337p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000095">
        <property type="protein sequence ID" value="TBU04721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000337">
        <property type="protein sequence ID" value="TBU13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCB4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0095p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0337p0020"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU04721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="147" mass="17291" checksum="9C767D3DF2359623" modified="2019-07-31" version="1">MRDDCEQSDERSERCSSDSKITEYKKRSRTVMSPGQAKVLKKYFEINTFPSTEVREELARTLGMKPRTVQIWFQNQRQKTKHRHEGLYNQLYNHAFYNSSLAQINHYLPKSCTGLDILAEAALGNHIDYKTTKENVMKNKLRDKTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD60</accession>
    <name>A0A4Q9LD60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0021p0040</name>
        <name evidence="8" type="ORF">CWI38_0826p0020</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000021">
        <property type="protein sequence ID" value="TBU05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000826">
        <property type="protein sequence ID" value="TBU12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD60"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LD60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0021p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0826p0020"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="157" mass="18751" checksum="5ABB52F891579F6E" modified="2019-07-31" version="1">MRILKCYFCSSNVYPGHGITFVRNDSIPFTFCRSKCSKLFKLKKNPRKIKWTKIYRKINNKELCNDTVQMFEKRQTIPQKCTSTTTTTIKELIPSILHLKNHKENVFIEDRILQAQELDKENCIKFLEKNKHILKNKEPPMKGLRSKQEKRKEELFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDG6</accession>
    <name>A0A4Q9LDG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2683p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002683">
        <property type="protein sequence ID" value="TBU05904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2683p0010"/>
    <dbReference type="OrthoDB" id="2191278at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="366" mass="41391" checksum="89C8B3F19E2AD984" modified="2019-07-31" version="1" fragment="single">TTPFKYTVLDKFRKEFEEGLKSQPFTSRSDLQNILTRLIDSNTESSINAFKSLNTIIDNNISCLLFSCNSIVSSILIQLNEFRRNKKKENNKEYCIYILQTLFKLTKNSFFSSYLSLDTLKSIHLDLIGYISEGCTVIVDILINLCLLCECDVILRVYLSMLSGSSSIKGVSDRGSIKGVNYIGSSIKGDNYIGSSIKGDNYIGSSIKGDNYIGSSIKGVSDSSNQHPVNDTLNKQHPFNNIPDKQHPVNNTPLKQHPLNTTPDKQHPVNVKRIGYNEVVLKLIWRNSKAKGYLTSRVKTQGVLKVLEEFYEKGVLRLFKDDVVALRVVQLHLEEIIGCYGSSVYDFNINGLLKVYVECVYKRMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE58</accession>
    <name>A0A4Q9LE58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2614p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002614">
        <property type="protein sequence ID" value="TBU06228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2614p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="604" mass="68836" checksum="334E12E63D9EC920" modified="2019-07-31" version="1" fragment="single">QHPVNNQTNEQHPVNNVYNTQHPVNNQTNEQHPVNNVYNTQHHVNNNTNTQHPVNNVSNEQHPVNTTTPNITLNTTPNINTHIWNLIYQIYFEKYKINTFDRNDTLNILKENEKYCDLYRKKINKKIKKEEEIELNEFENKNLIKKIINLRNEVLNEKTPKKSFFSYFWNKKVSKEDKKEIYKVIEYTDSKGSIVGEVDSKDSKGSVNALSNVDSDRNTNTYTNTNNNNLTLPTSPYLDSDSLEYVDALEPSDETYKKLTREVDNKENGSREIDNKEIDNKEIGRREVGTKEKDSKQSISKKYVCNFLVKNFNFNFKVNENIKYSISIENIESFISKEGRSIDLSLSVYNFNIFYKKYDKTYKILRNKRGVEGSSTSKEEGVSDRGSKEEGVSDRGSKEEGVSDRGSKEGGVSDSTNEQRGVSNSTSKQQGVSNTNNNTTNFCNVIYIKEKNTLNIFINEMKILNLKKIFLLFDKLKNNKINEIIRLLSIKDILEGDSGGGVNNSRDRGVSDKDNKQQGVNKSSMYFGGVNDKDSKQQGVNKSSKEEGVNDKGSKIEGVNDKGSKEGGVNNKDSKQQGVNDKDSKEEGVNGSTNNYHPLNNNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF01</accession>
    <name>A0A4Q9LF01_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2548p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002548">
        <property type="protein sequence ID" value="TBU06568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2548p0010"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="297" mass="35033" checksum="505049C774F94D8E" modified="2019-07-31" version="1" fragment="single">LNFLRVQKIVIGDFKFDNMMLAENLKIKAIDFGHAVFEKKQKRLFSDKDIKNGKNNHKKYLYIAPEIRNGQRCSSIADIYSFGYVSREYINDVIIKDGKVSDFFEHCLVPDPKIRISADVALIHPIFNTLYDFVFCFADIKNFEISDNDTKIKLHDRIIYYEHPEYSFELHCCCSKNKREFSKFKLNQNQKLLQRKTTNQEEAEQRAYKLLKFRAVVGNHVLPIQHLTFSYHNELKKLFLKLNIEQVKYKVVINTLKEKTTRKKIMIKILGISVLIIVIAECLLLSIIYRINNIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF50</accession>
    <name>A0A4Q9LF50_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">CWI38_2534p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="PITK01002534">
        <property type="protein sequence ID" value="TBU06633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF50"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LF50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2534p0010"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="35652" checksum="BFEC49FB93A0A9EF" modified="2019-07-31" version="1">MLEINKARDILNGKHYNISQKMRALFFLRNINNTESVLSIMSAFHNESVLLKHELAYVLGQMRDPTCIQTLKDVLSNTAENEIVRHEAAEALGNFLDKNNIDFLKSFLKDISIPVRETCYLAIKKIENHHKSENKINFEKSENFLKNHTSSDSSIQFDKIELSEFDSCDPAYPLIIDDNFLEFIYLKHSDIYLRYGAMFSLRNKKNISILVKGFKDNSALFRHEVAFVLGQLKMKESILYLKEVLDNENEHDMVRHECAEAIGAIGTDECHKILMKYLNCDADIVRESAEVALDICAYEMSTETEYCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHB6</accession>
    <name>A0A4Q9LHB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2389p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002389">
        <property type="protein sequence ID" value="TBU07518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2389p0010"/>
    <dbReference type="OrthoDB" id="2186859at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031543">
        <property type="entry name" value="DUF5087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17006">
        <property type="entry name" value="DUF5087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45849" checksum="2D8A34EE36BB1A49" modified="2019-07-31" version="1" fragment="single">VKNSFFKDSIIEDESVTSNFDNNPQNIIKNYLQETETFKTNDDEIKNHNFEDNELFDLKDNNLPYKTSVDDILEIFCEKKASPPQIKTNMSFEEFVYVCSNLQVSEPLEKYKEIFIPKQLIVFVENNLKGIIKYLFSNLEKWKPRDIYSVVTVLSTIKNDELKESILHDIIIFIKEPVLYIFYCYPFLLESNPNSIFIKTIKKILSFQVAVDIKIFKSYENILKILNKISENINLKLEIFSIESYCMELVKEVPIFENGNLNNEALLIGASIKLICNFMDWDWTYDQFIVEFLYPKFIKTNSPSIMYYICLITFNSYKDFGNHKSIKSIFDKIQEYISNENIELSLVAYLFIRQTDSNICKDWIETNQERLKKHISVDIDFINKTIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHG3</accession>
    <name>A0A4Q9LHG3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2382p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002382">
        <property type="protein sequence ID" value="TBU07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHG3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2382p0010"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF8">
        <property type="entry name" value="DEXH-BOX ATP-DEPENDENT RNA HELICASE DEXH15 CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="6">
        <location>
            <begin position="222"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="36675" checksum="17D23A9158671789" modified="2019-07-31" version="1" fragment="single">MPLPENLKKIISSSKIHPINPTLSLLLTPTYFSYNYNIDNTITLFSHTITSTINNTLIDSSIPSNTNTTNNTLKNTPANNTPYTNSINNTPYTNTMNNTPTEEQDSSSSFFSSEETEPTNSTDKNKDKSKDIDMDKSKDIDMDKSKDIGRDKSKDIDRDKSKDIDRDKSKDIDRDKSKDIDRDIKNTTNNNNNINNNTFYKFIPTSFTPPPIKHPFPYKLDPFQLQSIYLLNNNKHTLVTAHTSSGKTLIAHFLFNNSINNNTTTIYTSPLKALCNQKYYNTCEYYKGYRDSRGGVSEEGCGLKGVSDSIGNYNPVSKSTNEQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIU9</accession>
    <name>A0A4Q9LIU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2305p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002305">
        <property type="protein sequence ID" value="TBU08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2305p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13010" checksum="D254527E69AAF5F6" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMSVIMRAEMHEEPTPPLKEETREKDGAKNFKPKNKAPFISQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJZ5</accession>
    <name>A0A4Q9LJZ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2374p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002374">
        <property type="protein sequence ID" value="TBU07621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2374p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="39812" checksum="91482BBF06F2E6CA" modified="2019-07-31" version="1" fragment="single">YNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVRITFQDSLKIDQTEKLRKYDLLANKLGLIYRRSVEIIFYVMTWDVFVTKYHKFHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPRTPLKEEKREEDGAKKFKLKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKE6</accession>
    <name>A0A4Q9LKE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2256p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002256">
        <property type="protein sequence ID" value="TBU08487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2256p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12998" checksum="551DCCD07058B885" modified="2019-07-31" version="1">MREIHKNVLEDFYNIGNLENFENLEIFINYRENNNISTLEIKKIYEKIKKENLKINFEIFENNFLLKNYDFRNIECNKLKALLDIISHSEKREDIDVIVHLLAEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLI8</accession>
    <name>A0A4Q9LLI8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2288p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002288">
        <property type="protein sequence ID" value="TBU08241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2288p0020"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23531" checksum="30B84A7DE4B28FBF" modified="2019-07-31" version="1">MPETLRNDLIEGNKNILKICHMLETPLKTILTAQIIFQKVYPMLYTCESYNDVSFVCVYIASKIEETHIKLEAFLNAIFSIKNIKPKDCNSILVKCECKIVNLLKFNFDIKHSHFYFLKISKQIRMPEDVLLRKIEQLNDLHGDSRVNKISYFNDGLYSPVDVAFSLLSNEEIFKFEKNSFVFVNREYIENIKKEIFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LML9</accession>
    <name>A0A4Q9LML9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2156p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002156">
        <property type="protein sequence ID" value="TBU09367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LML9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2156p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="614" mass="73804" checksum="457D0F2E397186C7" modified="2019-07-31" version="1">MSFSKGIKPRYNFFEHKECSNCIKHIITDVDKFSLNFDIEDEEKGEYAIYINKNALNYDDFRCFLRIVREMNDIKENFRIVDFLCLIHIIDIFKFKKDKNFNSLILNLLHFTIYNSKKMYERLHIIEKFNKSSSLFESILCEICKIYFFNGKTFLLNILNPNDNKEIAEYLSETISTKSFVNIRFIFLNRICKLMKYNHFSRNTFKLICQVIGPRKVLLNLEDSNEVSFSFSMFKMFLSSEVICFYHWKDMKFLQSIIENCIFKNIKSLLKSIYLSNSSTTNTVFCHKIYNLMKNIVCSLYDEINNEEKLRKFMTLTNNRYCKTKKYHIQYFDPKIEGFDFQDLFCSKKYKIISFDSIVITQSFVSFKTTILNHENFSRMNLILKKVFLTTLKFQNTLVKESIRNLYIYNSKLTNKCLFDILLLSNLQVIQITDSTFIFDNYKIKYIEHLLIQEFFINRCESEKNDEIFEFINSMPNLKSLKLTPNSNISLFKYVFKYNMMKLKNLEKFKIKDENKCDKGYSDSLYLEKIIELEINCLFEQSFLYTLFLNQKLENLEKIHIYNCNIGLKDKNSRRNYTRIQDILFSNTKLFGISFSELFDSQKEYSIKYIYIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPF1</accession>
    <name>A0A4Q9LPF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative elongation factor Tu GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1836p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001836">
        <property type="protein sequence ID" value="TBU10343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPF1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1836p0020"/>
    <dbReference type="OrthoDB" id="2193278at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="48"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="723" mass="84812" checksum="9D9B41152D623C6B" modified="2019-07-31" version="1">MESFDEFGNKIESKDENISEIRSYEYKFNKCTVKNYDFFRQIANIRERVLNVGVIGSIKSGKSSLIKYFGNFTNFDVEKIICDENDNFDLKTFNFCGKTIHSEYESQRDTTIHYKPITFLLQNTKEMSVIVNFIDTSSHIEFYRETQEIIPYFHSTVLILDISEDISLVCRLYLKNISNKNTILVLNKLDKLIIELNMPLSVIFEKIEYLRSKIKTENIFITSLVRNIIFKYNEDILASFYEAFIDEQRIQKNSKIIKIIKSLKISNFEIIDELFKIKKNNIECKEMCIKKHYRVENMILPLYFPNLNSYTQINTDNSIDLDIKNNNQKSNKTLDQKFSIAQSKSGSLENKIFINNNEYKVIKKFLILKNGVVEVDFFTKDLPYLVYLDKEIKEESNGSNEENIISVIVENVSAMKILKRLYPSINIRENIISGPSEPFLDSVFCDINKMGINCKIIYIFNKFKETIKSKKICITAKFSIFIEPISDNKNIYFNFENNKLIMTKETIYNHFLNSLNESDNNIESNKVQDKKNLKSCDLSSNINEENKNDKIRLQKYKGNNLYYEIKNTDKVITQASKNLSKLFKNFINQGPIVFQEVFGVNISVNFSKNNSKTGIYFQKECKKLFRSDFKILEPIFYIEILIQKHHLNFIKSFITSQKGKINDIFDVPYTEYNIIRGEISAFNSFGLEAYIKNTAFCHIEKILIGYSEVPYGFEEYKKLNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPK5</accession>
    <name>A0A4Q9LPK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2003p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002003">
        <property type="protein sequence ID" value="TBU10127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2003p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18256" checksum="29CB2F31EEF28738" modified="2019-07-31" version="1" fragment="single">MNILILIKQEIFIIIVFIVGQIYLSKSNKTIPDKGMFPYKEETTYFEKHAFNLIEQLFSGYSKNAFNDVYFIETNNLTTNADFEGFINKITHSKTIKTHFFYVQFDWSEDSNLNSENIIKKILCALNNHLEGKMCKPKEKIVINNGTNFIYEDISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPS9</accession>
    <name>A0A4Q9LPS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta subunit of transcription factor IIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0316p0060</name>
        <name evidence="8" type="ORF">CWI38_1753p0020</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001753">
        <property type="protein sequence ID" value="TBU10449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000316">
        <property type="protein sequence ID" value="TBU15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0316p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1753p0020"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="209" mass="24382" checksum="E963B7EB6045854C" modified="2019-07-31" version="1">MYHNYNREPSYRHLNSYIHAILTLLKQHDRPLSFSEIKQSLNIDLTQNRQLFDILHKNPKITFTNDTLLFQPLYNIRSAEDLEKIMKESEGGLLLNDLLDSPVDVQPFIAELQKENKIFVLKDTDNSQIVFFNDTIQNTAAPQIKSLFHTISVPNYQDLIKELNTAGIKSGIQEEKKRYVVVQKSKVKKYKRKIKITNTHIKDLNLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPT4</accession>
    <name>A0A4Q9LPT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1719p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001719">
        <property type="protein sequence ID" value="TBU10493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1719p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20024" checksum="B565BB46A80435FD" modified="2019-07-31" version="1" fragment="single">MYQDINWSRKAIKYVHLFLLIQEILDNEYAEIEVDTRTKTNAIDEVSFDLQKEPECEERTEERRKSAPFGKSATNDTCCEDTATLLQGVSVYKYLGIIEDSRRIPTRSSFEEVQNKLISRNRQCDVLVKNKIHLRPGCKERLYLPRTELGRGLNSVEVRSEHMLLTLGLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU5</accession>
    <name>A0A4Q9LPU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2138p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002138">
        <property type="protein sequence ID" value="TBU09561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2138p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="585" mass="67839" checksum="DE9A03D339331AC7" modified="2019-07-31" version="1">MIKHPMHISFDNLSSEKKYFDKLLEKNNSVRIRIPRNIINDVNLNFNASGTFENIHYNSFPISERSEYNAILSFLYKITDSDVRYILHRYSDFLLLVFTPILQSHSTNEKYISSMPPIETLYNLESFIKLNEMVRNDSEIQNYIMATMNSIENDGFGANISFSFGINNNLSSVNSLLRNINISSPFLNAEFNNGSKASFFRDTIKFNYKGYFALYILLTFSRYGSSNLLHKILNNKCDVSDAKIYDNFKKLFNALFKTTNFFKNHNFNCSVPISIKNVFNYVNNISTISNEGVYIDFVGSSLRNYQTNRFSLRDDDVFALVNDCFNRTSCFFLGESRKILMFLHVLISIYQRLSIQNDSYMNLALGCVVMIHRERIKNLNLDDVSIQENTLFFIFECYRLAEILYSTDYKIINALDGFGFDKICSTVSEILHKDFNVIQSTYNIEKFCKPIFLLRSANVSIYKLKKHALTCQNGILQDVYLPFYLCIYSFSKNIQDFSNIDTLILASELERYRSRYYKSIEMGEGYSSINFGQNTSSNFNRTERKISLIFAVIFGTLFTIVFIVIIVFIIKSIINSNSSKSFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQA7</accession>
    <name>A0A4Q9LQA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1639p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001639">
        <property type="protein sequence ID" value="TBU10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1639p0010"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020517571" evidence="1">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="350" mass="41503" checksum="7F57A958436DB6D9" modified="2019-07-31" version="1" fragment="single">MGNLFLFLLSIDFISVSNRKRNYSPENDDNDVPSKLCYSSEIYMNKIVEIQQENTNSEDIRDMIEKNWGTVLENINNYIRSVEESRNQKLPQSEVYSNVSNGLGILTKFFNTYGYAPEKYKNNEFEISVDSWDEKIFIDELNEMRGYVKTTNIGHPEFLDKIFNFSRKLILEIEKRKLHSKLYNARKNELVSVSDSSRWPRDEAVFCYIQDRNVFWGADDMYYLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFRSSKRIRSHSVQEILDNEYTEIRVDIRIKTDYDLLANDLGLIYKCSVEIISYMMTWDGIGTKYHKSHPKRLEIPMNVEAYIQSIVLKKTVETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC1</accession>
    <name>A0A4Q9LQC1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_1629p0010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="PITK01001629">
        <property type="protein sequence ID" value="TBU10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1629p0010"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="440"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="19">
        <location>
            <begin position="769"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="924" mass="107602" checksum="4C3591C35BA19707" modified="2019-07-31" version="1">MKSVLKFSLLFLISILAFVIRLTGIFKYEPILQEYDPYFNYKCVKHLVKHGLLSFIRWNDMTVWIPFGRKIFNTSYPGMMICTYLLYCISNSFLFLLSHLCISPLTLCIYFPAICSIPTTFSMYMLCNTLFDRSSCSLLASFLYALCPAYISRSISGFYDYECFSMLLILLSFNFYIQLFCIKTEKTVYKCINKMHKQKKKKNENELEEYKESKEVEEIDKSKEECKAICKEEYEDKCKEEHEIEKSKAICKEESKEECEEKYKIVESKEKNKCKSMNFLTNNFKPYFNTFICFIIFYQILCFSWGGYTFVINLISLHSLALIVVGFIYTVIDRYTFKGRVKGVNTRDSYKEDVKGVNNLDSNDKGVKGVYDKNSNKEKVKGVNTKDSNIEVVKGVSTSTCKQDPLSINTCKQDPLSNTNNHNSVLYNNTLLFIDNPKGYSEINYWVFTCYFIVSTLITYLVPFIGSKALFSQEHLFPLTVFILHQIIKGMNIRKGNKILFSVFLLSFLLIFFKKITFLIQKLFLGRGRLLDLILRKKGTSALVNSVSEHSPRSFYGFFLDFHFLILIFPLSLKKYLYEHKIGVKSIFVLLYSLVALFFSTRMLRLVLLLGPIVCITCSYYLIYLIKKCQKNLTGNISDIVKDGNKCDMSEDGNKSNMREDGNKCDIGKDGNIDDNGNISNNGNMSDINDSANTRNGYLTDMTDIGSSIFNIGSLFVLVYLLFLYCLHSVWITSNHYSVPYVILYNSRNEVMDDFRESWSFMKNNIKNENVLCWWDYGYQISVMGEVNTINDNNTCMGERIALTGKIFLSEEKEANLLCKKENIKYIYCVVGVSNWYSSDDLNKIGWIKRIVSETFGESYLSINRDTEEYKNMLLYKMSYHKMENVVGNMWDSVRRSRFDKCEIKYFRNIFNSENYLIRIYEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK9</accession>
    <name>A0A4Q9LQK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1626p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001626">
        <property type="protein sequence ID" value="TBU10654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1626p0020"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="19412" checksum="ED4C019341FF4875" modified="2019-07-31" version="1">MKNKYSVKIANFDGVKACVNKAKVSFKNTRETSRPLLKKSLEDALKYLADVENFKKCVPFTRFNGGIQCTSQAKGLCKPNKGRWPLKSVRLFKGLIDNLVENAKAKSMDPKVLVITHVQVNKAPKVHGRMHRAHGRVSPYNKSPCHVEIIATKQKVDVPLEDEDLKVEELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR22</accession>
    <name>A0A4Q9LR22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1707p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001707">
        <property type="protein sequence ID" value="TBU10516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1707p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="54152" checksum="495B9E6426DB34E0" modified="2019-07-31" version="1" fragment="single">NFESLNNILNLSISDRPNGKIECNFDLLYFLKSTKDITEIPDEVNHIDIKTILIGFKYLKAINNKNMSKFIQALIFKIFLTPNKSFLKKNCTYIQGLMDLNFWSKMDFYITKSFISGLLNIWMINNIFRDGNLILIKNTRRYYDFVYFDKHIPYKNISIDSSRVLLHLEKLLRDQIIFNFFQILLNEINLKSLILDGSIQNILSIEFTCLLFSRPIFKSITLYNFKGYSSSNFLMNLGIVCRNDIEFLRFERLNISSSLLRTFLEKKKLRGLVFYNVEIFETALFLDRYIDSIEKLEYISFVNIKINSIWWCKLFCKVNLSTLILSFNSIASEQSFFDGFSKVSIVQYTLHLEISFYSLKIPKEFCDSLFYFKFLRTLKLQNYKMNEKTEYYFLRAIENLNDLEELIIQQSHLSTKFNDILLKKQRLKTLHIENYFSEKRNLEIVLWDSYKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR54</accession>
    <name>A0A4Q9LR54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1411p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001411">
        <property type="protein sequence ID" value="TBU11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1411p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20938" checksum="ACB7BCE208151FF1" modified="2019-07-31" version="1" fragment="single">MLLQHLNIFEKSKSKLTRRVTILKVEKDNQAYLALIKLFKNKIWVRKGFEKITLIDEEDMKLGGTSLGVIEGATMHEYHILYSNNRQDNNNPEILTQNTILIHFYEALDNSLRVNNSDTSHIYESEKYLTSDFFSNRKILRTKIIDLNIFLLEFLIEEQINQYEIYIYNEYLSYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR97</accession>
    <name>A0A4Q9LR97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1550p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001550">
        <property type="protein sequence ID" value="TBU10787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1550p0010"/>
    <dbReference type="OrthoDB" id="2201204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27965" checksum="3854E935D8FEE7B6" modified="2019-07-31" version="1">MSTKRKLKSVTINYTRFSSLDNLIEIINNSSHFQIQILTLEAFETFSEYLKYKSIPYKPIYPSLTNMYDKKILNIIFEHPNTNLVNYKIILFNKSIHLDFIPYIFTISQSEKLNYLKHKYSQNLISEIKKPLFLEKNIFQLSNHIKFINFPICALILTYLEKVILFALNITNRYEYLFKTVKEIDNNLGNSFLIKVTLNSLVNKNVIIKRGNIYSIIVDRKTIEITLKSVGFDINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ7</accession>
    <name>A0A4Q9LRQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1371p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001371">
        <property type="protein sequence ID" value="TBU11124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1371p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="18414" checksum="0CB5C06869066DF5" modified="2019-07-31" version="1" fragment="single">LRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERTSMGVIMRSEVHEEPIPSLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR5</accession>
    <name>A0A4Q9LRR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1311p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001311">
        <property type="protein sequence ID" value="TBU11233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1311p0010"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="149"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113286" checksum="2780F29B213623A5" modified="2019-07-31" version="1" fragment="single">TNKQQGVSDNDSELEGVIDKDSRLEGVRDKDNELEGVNNSTYNQDPVNTNTYNQDPVTTNTYNQDPVTTNTYNQDPVNNSTYNQDPVTTNTNTTNTNTTNTNTTNTNTNNTITRSVPVLENNTFTSLLQQIPLDEYYKIMIQSSGKMVLLDKLLAKLKGSHKVLIFSQMTRCLDLLGEYLNFRKYKYERIDGSVRGECRQEAIDRFCNKDSDVFVFLLCTRAGGVGINLTAADTVIIFDSDWNPQNDLQAQARCHRIGQLNEVKVYRLVTRNTYEREMFDKAGLKLGLDKAILQRLSYENKPSLKYKDSIELLLRKGAYGVLMENDEISVKFCEEDIDQILERRSKVVKHDNLYEGGNIFSKASFFVEEEIDDPDFWDNLVNKKKSEENEGRIKRQIRRLGREGVSCSEVEEIDRMIKEIEERINRIGGDIEGGVMGGDVVGGVNDSREVGGVNTSKVVGGIGGVNTSKEEGVNDKSSKVEGVNTSMVVGGVNNDIDEQHPVNTNTNTLHPVNTNTNTPTPNTTIDFTSLVFLTVLRKGVNSLSTLKYPSDPIPYLNFCISHCLEKVENKMKEDYSLHMDGYIKGEKKGEIGNCDVVGSDVVGSDVVSSNNSNINKSNNNTNINSNNNPSNNSNNHPSNNNNTNSNNNPPNTTNIFDRFGNRFLLRVQVVVILGILMKCEGLGFVEKWRGWSYEDDKRLVNWVLTNGYDNYPCNVVGSSRRNVINKEGISKEGISKEGISRESITKESITKECISNNTSTNPSITNPSITNTITTNISNITPIPKNKDKSIFRGKSEDELNARIRKIILSLNKKINENKEEDNDLEILEIILNYGRVSEKNKENYYKSLENILEGKELEGKLEKVESVIDKSFKKRRKREEKDEKMCYRVKMFDKLNEMCDKGSIPSVRKSSGLPRKWSSEYDKEMVDVLVRGGFCIGEDVIVRRVEALIKAYGNKEESNRYGIRLDNKTIRLVDYKTSDVSLGVSSDEEDKVLISYEEVLYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS20</accession>
    <name>A0A4Q9LS20_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1253p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001253">
        <property type="protein sequence ID" value="TBU11353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1253p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17708" checksum="61A23C70EE10E042" modified="2019-07-31" version="1" fragment="single">MDFSYLSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKKKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE4</accession>
    <name>A0A4Q9LSE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1327p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001327">
        <property type="protein sequence ID" value="TBU11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1327p0010"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="35403" checksum="FF5EB3067C1B34F2" modified="2019-07-31" version="1" fragment="single">MIIPIRCFTCGKEISSKWEPYVDLLGQGRTECEALDILGLGRKCCRRMLLCHEDIIEKVLNYDVFQNLSQNSNVFAMLSKNQIFELKEAFGLLDTNNDGIISKEDLKTFLSSIGDPFTESEIDEMMEEAGNEMSFMMFLTLVGEKLSCTDEESVILHAFKDFDENRNGFVEEKVLKKWLTQEGDKMCEEDVDFLLKDCCENGMVDYKKLTEIIKHGEVLKKEEILGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESCERASMGVIMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM8</accession>
    <name>A0A4Q9LSM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1146p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001146">
        <property type="protein sequence ID" value="TBU11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1146p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15995" checksum="A46DBD5AA42BC3D6" modified="2019-07-31" version="1">MENIFLKKIKNTFTKLYFISPFKLLLTFLPHTQFSITLSTNLPTLSAQQLRKSHPNAKFMLLNQNIIFSTIVDISTDFPYIFVINPYFDSFENEFFNQLCVSIKCTIICIFNNENDYIEIENKLFYISEYCLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR6</accession>
    <name>A0A4Q9LSR6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1676p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001676">
        <property type="protein sequence ID" value="TBU10570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1676p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="3">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="479" mass="55641" checksum="EF506E4F6A3D3FAB" modified="2019-07-31" version="1">MEANDEAQKLKSHYEELIKAYKKIEKKLKTNNNQDNEYISGLYSEQQRLINSITMFNAKYINFMKPRKNSFGKFCDDLFRKKKLSNEISSFQAVQSKNMERKSETTPHTSEQNAPSESYDVFKNQNYTDDEVRTIDPRLLETQTPQDPSEDPLLNRKIFKSAKDSYIQMANQPQRIPPSNKTTYPYFPYPPMGYPYFSRSEDSLRMMPQDPRMFPPPMYGTSPSFTNPPGMNNNLVPPNYMNIPYGPNHMFTPQHPVRMMQGPVPPYNNQAFSKQSPVYSSFYPQSTNQNLYENPRAITPNQNIVYPPVSPSKTPGSSQQYVQDTTLKKKRRLSVQSPLVREHEKAGFMFPHFSFTQPQIKADSNELQKLEEFIAKRKDVREVIKDVDSEIILDNGPAYLLYRIVDTFIEKLCSTACKFARNREDINVSCDDIKMGLYSEFGLELPTDCVIKEFKKPTDEHEKMVNAILKENRKNNDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSU7</accession>
    <name>A0A4Q9LSU7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1091p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001091">
        <property type="protein sequence ID" value="TBU11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1091p0010"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39584" checksum="1FDF4D9A4C039FEA" modified="2019-07-31" version="1" fragment="single">MGSGQNPTRSSFEEVQRKLIQELNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRLGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKTAIIKMENNNKTHLAIIKGFLKVKYRLVEEVTKKSLGEAQLAKLSNEIEKRKLHSKLYNARKNELVNVSDSSRWLKRGNIRPLNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQKILDNEYAEIRVDTRIKTDIKIRNNRPDIFILDKKKNKITLIEVGITFQDSLQIVETEKLRKYDLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT61</accession>
    <name>A0A4Q9LT61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1191p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001191">
        <property type="protein sequence ID" value="TBU11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1191p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="12090" checksum="03398240FEDA857E" modified="2019-07-31" version="1">MHFKLFNYTYILMVIINNIYSSPYQALVRFGDYNQVANDEIQNHMKHEQLPTSNEEAIPFEIFSRFAEPVNTYNDEYNNENTRKSIRKRIIIDGSPYVIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT96</accession>
    <name>A0A4Q9LT96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1020p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001020">
        <property type="protein sequence ID" value="TBU11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1020p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="258" mass="29833" checksum="DAD363ADBA81BA6A" modified="2019-07-31" version="1">MHMRYLLRLEPADFSKFDDAVRAVLVKNKIHLRLGCNELPNKTAPILKVENKNKTSYTNKKKKNLEEAQIAKLYNEIEKRKITVSDSLRRLKKGNIGLHDEASSITVDHLATRCKKNLGHDCTRQHNKVSHSVQEILDNEYADIRLNTRINSDVKIRNNRPDIFIFDKRKHKIPIIDVLGLILSWCEVMSYVITWDGIMIKYHNRDLMAKRASMGVIMKAEMHEEPTPFLKAAKNEEDNVKHLNTKNVITLILDGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA0</accession>
    <name>A0A4Q9LTA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1453p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001453">
        <property type="protein sequence ID" value="TBU10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1453p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="29393" checksum="A2536BCEF981138D" modified="2019-07-31" version="1">MQKKFLKIKFNLEHEVTQLAKHITKFKKESFIQSNILAIEKKYWQRDRAIFCYIQDRNQGISENTLAVIKVDTRIQTCVEIRNNRTDIYILDKKKNMITVNEVEITYQDSVHIVKTEKLRRYDLLVNGSWLIYNCGMELIFYVMTWGSIVTKYHKSHLKRLQIPMCAEAYIQSIILKKTVETISFDRRRGLNWERASMGVIMRAEMHEEPTPSLKEEKREEDGAKNFKPKNKDPFISQGGTTLEEPPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ4</accession>
    <name>A0A4Q9LTJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1187p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001187">
        <property type="protein sequence ID" value="TBU11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1187p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="21869" checksum="57D45A280CB26F5A" modified="2019-07-31" version="1">MKTSKFYKNSFDKLFEKISKIPLLFIETCNDKDIKTDFRIFYYGFEKINLNYDFLNYLNSDFFNTINSHEQRTVESNIYLRKGVYNSEIFKKIEIFFKNDEKIKLLKLNEIKNWLKKNKKIFLQINSAIDNGIEINYYFLFEIDKYEDPCVNFTFFTDCTDFLWISNQLYDSIWLFLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ8</accession>
    <name>A0A4Q9LTJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1110p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001110">
        <property type="protein sequence ID" value="TBU11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1110p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="50982" checksum="380F6CEEFB013EF4" modified="2019-07-31" version="1">MLNIHIKNTTNLLSALQYRLTSPIILYGPPGTGKTHILYKTLHSLKITPLYFPNPSTYTNTLLFTNTIAHTDIDTLEDFNKFLKNNTHPLNIVIETRNLYFLSKCVKGSILVKFLYTTNTLLSKYNLVTPNLHSLSIFEEVSRRGVSEEECDIKGVNRRVSKRGISKRCSKRGVSKRSSNNTPLAISNINNTPLTILPINNTPLNISNMNNTPLNISNMNNTPLNILPINNTPLNILSCYNTSLSFYHFLGKIFYYDRDRDRDRDRDSDKLKDKDKNKKKKDKKFENKKEDKKEDKEDKLDNKEQNPDIIDNPSDNKALQILNNISFFKNKIKDYLFENYLYFTDIREQGVIIDNLSLFDCYSEGVLCNVICVMGIEKLKPKCFYSFKSPYYLKGRGRGGCVKGVNYYYSKGVNYWYTYYCYIKGVNISTYYKQVSNKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM4</accession>
    <name>A0A4Q9LTM4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1097p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001097">
        <property type="protein sequence ID" value="TBU11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1097p0010"/>
    <dbReference type="OrthoDB" id="2375545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="NrS-1_pol-like_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051620">
        <property type="entry name" value="ORF904-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372">
        <property type="entry name" value="ATP BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372:SF2">
        <property type="entry name" value="SF3 HELICASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="628"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="887" mass="102684" checksum="38DBCDDC388F69C0" modified="2019-07-31" version="1">MEIKTNSIEEPESEFEIASCREEPNEETLICGYTTSIYGKRMTIVGKDSFLAVYKNEISKGYFNEYLRESAKVVLFFDLDSKDFELTRLVQDIKTLISNYFIGFDTQFIVTDATGREKFSKHMLVRLFKDEKAYVFRNVGEVLNFVRENLRLDGVDLNVYKPGGCLLRAFGASKERVSRKLLLDLKNTGPIKDIQLIDHFVQWPGELGECLGTFISKKSVACFKEVTPRVTDSTAIAKVEEPRENQSINNVFVKILDFFKFKAKKIYRPRYSEIKDGVLIVYVDLEPLDVCPYNVVHKSNKTYLRITVISAILKCHGCRLKTTLPVLETRLTVVLSHDEIYLLFKGSMRKKRSRVGSPERVQELLGVSGLEEESYHNLSTVAYSIVSKDNTFNKPFQKDRNIVACQSELKKFSKNFVEINNRSYMEDLEETFSKPEFIELVYDQTYFSKQKLENDLDSEDFFLRVFLDSPTPVLFARFLTVVLKGRALVCKENLYLANMYNVYKEYTKVDTIGILSYFTEQFLKSLEYSRKILKEQHSLKECKDGLFSKYLRMRMSLESPHFIRAVMCVLFPYLRDEAKGLTFDTKFSLIPLKKSVFDYQLRKIRKIELEDYISFTLEYSEEDMLFSDNRTLAYKFMENIFKDEVEIEYVLNELRIILFQKSNDKIYFLIGEGANGKTTFVNMLRKALCGLVGELPVEALSSTKSSGMNPFVVNLRKCRIGIVAENGTQILQVDMIKRLAGCETITVRTLYSNPVIFPFNTRLLLIANNLPKFSAIVDYALSRRMMYIYFAKNLSIKENIKYNLDLKNETVRDAIGLGFCEIPGKGDKANTLKYVYEKPEYSFKLTEFKAFAKSKICVDETHTRSSDGKSIRAFIRPQLNDNLQTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP7</accession>
    <name>A0A4Q9LTP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1081p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001081">
        <property type="protein sequence ID" value="TBU11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1081p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10730" checksum="0E86AFD9DC7FE16B" modified="2019-07-31" version="1">MNQIFAKSRIDMCLEDDPLCENSQTGTIPSDRLRISEQKINDEEIMEREQMGQLTFPLKQQKTLIEDLTKLNTRGLVLEEECLVAKEVERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR0</accession>
    <name>A0A4Q9LTR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0372p0020</name>
        <name evidence="4" type="ORF">CWI38_0937p0010</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000937">
        <property type="protein sequence ID" value="TBU12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000372">
        <property type="protein sequence ID" value="TBU13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0372p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0937p0010"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="36755" checksum="474CDAFFAE3ACA56" modified="2019-07-31" version="1">MNTATLKEIGTLDCHKNMVTCLKINEEGPQERLFSSSRDKKAYMWTLERTTDGIGKVMKEYDQHNFYVNSIVTNKTGDKLITACADSVVRIFDVETKDMKYLKGHSGDILCVAINSNDNKIVTGSMDKTICLWNTEGALVRRFGSGITNSQKGWITCIAFMPSNEDNILTGSTDGTLNVWDIETGEIIKTYINGSEIKPSYNEEKKRVPKTIKCAAAVTALSITPDGALCAYGSRDSEIFVFNLMNDGFTKIIKTDSAVTALAFALTDTILACATETEICLWDVINNNWLFKLDCSEYGKNVHCSSLVWSRNNLIAGFTNGKIIVYDCPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV0</accession>
    <name>A0A4Q9LTV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0916p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000916">
        <property type="protein sequence ID" value="TBU12058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0916p0030"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="326"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="46286" checksum="484422893AFEEFF3" modified="2019-07-31" version="1">MRIIIKNLPNKITELQIRSSFSKFGEITSFLLPLNEKEKPKRFCFIGYSKPNNVVNLMNNSYINNSKISVEEIDNEKYKKYKNGEPDGINIGSDMTNSRVYVTNLPNTSLDIKDEIYKLFKLYGGITNIVNDSFAAIVTFDTHVSALKSLELNNCEFLGVLIKVRMYNNNIEKRFNTFFFDFKSIINQYKSKDKEVLLNLKDSDLGTNISLLESHLIAKTKDFLVANNIDSSCFTERFDKKVLIVKNYDVMGSISDSFDCRVSVSPFGSMALLYFKDEENARKAYKSLNCRRFGDKAVYCDYLPICIQKKKILEENVEIKQKNSVNKLIVKNVPFQADKNEIKRLFSSIVSVVDVRMPVKGDKTSRGFAFVTLKNANDVTKAIEYLGTNTHLYGRRLVIDKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW7</accession>
    <name>A0A4Q9LTW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-variant domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0910p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000910">
        <property type="protein sequence ID" value="TBU12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0910p0010"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="30483" checksum="FB4DF920E543B539" modified="2019-07-31" version="1">MNENIIYETDECNEMSKKQPGEKIFLKTKFESDVKCKICYLYRNPIDSTCDLISPCGCKGSIKYVHKTCLKLWRFKGKNLREIKKCEQCFCEYKIDEDLIPHQYLIRLTSIFAMTVIFLSSNFIINSFGDAIALISDESNNLEQEMIYCIFKPKPQKIPNFFQNFRFLNDKENFKIGYLASTVIAIMFYQIVFRFKFFPVFNYIFTIWRIFHFDFTIDYFILYIMSFYYTKMMYNDIYEQTDYIFVFLLNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW9</accession>
    <name>A0A4Q9LTW9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0962p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000962">
        <property type="protein sequence ID" value="TBU11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0962p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="31551" checksum="D7F86CB2E80BB676" modified="2019-07-31" version="1">MSKQKKRVSDECMNNIFEYQLQERKTKIKTGICKIITHGFTFSIFYIMFLLYYIILTYFFIMRFDPNIVYKSIKKYFLLINLFLPHIVYHLTIISNDLGDVLLKLLIFNMSIFICISFEIIIDIKNPLHIENTLPIFIQFIYQLLRLMISFKYFADFVSFIFEFEKQSVQDTSNLFLKLVIFFIIEAILKPHLINSMNEILIFFFQSIFLIFKILYMASVIRRTKCILNRTLGVIFYILFNIMFDWNTYQHFFVNKTSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ6</accession>
    <name>A0A4Q9LUQ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0774p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000774">
        <property type="protein sequence ID" value="TBU12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0774p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10467" checksum="78F70AB35E5EA553" modified="2019-07-31" version="1">MSKLRTIDLKCIFQIRVKIRFRPLKKYDMLDNDLFLIYKCGKTLNTYKCKSFNFSIVLRKIIEKISVDRRIRLSPDQMPKKAGKEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR9</accession>
    <name>A0A4Q9LUR9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0767p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000767">
        <property type="protein sequence ID" value="TBU12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0767p0010"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000052">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="372"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="544"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="697" mass="77718" checksum="7C214EF0BDC7587B" modified="2019-07-31" version="1">MCGIFAYANFLTKKSKKEISEILTNGLRRMEYRGYDSAGICIQDNSNSRYSVFKTPGKVQSLVDFVEKQNETDMESETTNHVGIAHTRWATHGQPSERNSHPIRSDPSGMFIVVHNGIITNHQTIRAYLESKGHVYESDTDTESAAKLALYFYKESIKKGEKPDFIKIVKKVIKNCQGAFAFIFISPVFPNEIVAVRKSSPLLIGIKTVQKMTLDFFDVSFGTEKDDEPGSPLMHQNTVANSPALSPLFRDCHISTLQSTPTSQMEMFLASDTAAIIEHTKKVIYLEDNDIAYITNGNLVIHRPNSKEKDQFKSEVREIQTIKTELTQIMKGNFEHFMMKEIYEQTDSVINTMRGRVNYDESTICLGGLKSYISNIKRSQRLIFVACGTSYHSSLANRAIFEELIDIPVSIELASDFIDRRCPIFRSDCVFFISQSGETADTILALRYCLERGALCVGITNTVGSTISRETHCGVHINAGPEIGVASTKAYTSQYIALLLIALQLSQDNLSHKERRTEIIQGLKNISGLIKNTLESDRKLKEFSTKVLGSRVDLKSLLILGRGYQHATCLEGALKIKEVSTIHSEGILTGELKHGPLALIDENMCIIVIVTKDMLYEKTLNAVQQILARKGKPIIICSNDLIKEFDGLDVIGVPGTVDCLQGLLTVIPLQLISYHLAVARGYDVDCPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV50</accession>
    <name>A0A4Q9LV50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0750p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000750">
        <property type="protein sequence ID" value="TBU12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0750p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="45322" checksum="BBC609B67DD82256" modified="2019-07-31" version="1">MIFNVFATIISAATYTTNPKRAISDCLKNPNQNIDLHLTLNSDSSNDFMEMDGSIHYKQTNCCSINQNISDCVGNEPIQVLGSKKSSNDTDLLAFETNLDMQWQECTADKNLGSEKSKKNGSPFKCINIETTKSEKKLRNSKNESRVRKHRLKNKIIAPKLIREKVKKNKAAEKYQILDIERKIQENIYCNATEKRFDTYCYYFNMLEIFRLRNNNSSKSLTSIILDNIMFGDPNIPTEEINNQVCYFMQTMDYFAIQSIHIQTNTHIGSDEILLRPNEIFKNLLHDCFLYEFKAKSYFIENKNQEICFFLFSLISNVLITEIEKNEKISIFIKKSNDEYDGIEKSNNRIYTWKKKFEFSIENINPKKNMFSTKKKIKSNGTFYPPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ2</accession>
    <name>A0A4Q9LVJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1109p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001109">
        <property type="protein sequence ID" value="TBU11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1109p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="231" mass="26165" checksum="095F54526E580357" modified="2019-07-31" version="1">MVSKRNKIRISLGVVGSILAIFGIICVVGYIKAGNVIKSFEDDYKKFSALEDDKKFTSLVNLYKFGYFGSDKEESGFALIVKEKMESSVKMAKEALEKKNIKEFWGLFLSYCFSKEIDMDISKLEKVVGDVGLLGRLGFWFKGYHLIKPTYALSSFIHKTIKNPKKDEVKYAFLDIVDDSVVKVFDVKYDDKGPKSIPSAKKFKFEAPKNGISGKPADFIAYICYKVKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR6</accession>
    <name>A0A4Q9LVR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0624p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000624">
        <property type="protein sequence ID" value="TBU12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0624p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="35851" checksum="9F7955744CDC1986" modified="2019-07-31" version="1">MCKNTERGILQKIALAIVVCLCMDPLNRILNVKYTKGTIHFDVDSGCTIIHFLSIILGPSLTDSSTLGAMPDEIDKDRSATYRVFCEDTDTLIEGVSVCDYLEIIEDSNSNPTLGSFDEIKRLITRVERLFELDWHQKLYLMQLINMRYRVLCFEPADFYNLDDAVGAVLVKKKIYFSPVCKDLFFSITKLETDLDGNPSYSNKKLLKVEYRLEEEDGIVTKYNKFPLKRRQIPHNVDTYIHSIVLKKTVETISFVQQRELPTTPLKETNNDEDGGTSFEEPTININGKSDIEGGIVNVKDVKEVYKSHNDVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT5</accession>
    <name>A0A4Q9LVT5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1063p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001063">
        <property type="protein sequence ID" value="TBU11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1063p0040"/>
    <dbReference type="OrthoDB" id="2189195at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="1">
        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="22723" checksum="86F8AF4816A4ECFB" modified="2019-07-31" version="1">MNTIDELINKIRSKKIKKEETTGDIVNKTTGDIVSKTTTDTNTSISNTNTNISNTNTSTNIDTNDITDTLHKYKESQDIEIITSQVYPTTHTTTDFKNLQSIKNKIQDFIEIKEIKETEKYKIENYLISIVKRIIKYDNIVCGIELIDETGEIKGSLFCETVHIFDIKIGSIVVIENFSLWKINETHLNISSENIKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW1</accession>
    <name>A0A4Q9LVW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0969p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000969">
        <property type="protein sequence ID" value="TBU11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0969p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="8681" checksum="CA581AD9884F44D5" modified="2019-07-31" version="1">MSRTIILDVDSIASDSEDGEIGGDTSSDDSIIITHRRKRLRIESESSISSSEAEETPTFTNIPPTNVFSKATNNFFETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW06</accession>
    <name>A0A4Q9LW06_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0620p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000620">
        <property type="protein sequence ID" value="TBU12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0620p0030"/>
    <dbReference type="OrthoDB" id="2194154at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="766" mass="88828" checksum="77160EC9EF6CA428" modified="2019-07-31" version="1">MNESLNVYEKKIAMHESSKQFLKENRMFELFRGRFYRGLSERVESEHVVSRDEIVGFWSTMWNKNDETVMYDDYLIPFVSDNHPTTLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLAENQLGTVRGVQGAKEQALLNIALNKEYGNNLKAAWIDVKKAYDSIDHAYLNQCIENLNLPDCILKFIRVIISKWKIDISVGPEKIMNKKIDRGILQRDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESYSTIHLLFINDLKLLAKDSSTLSAMTDEAKEFLDVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIKDSRGIPTRSSFEEVQSKLIARVERLSHTRLNAKNLFSVINQPAISLIHFHIGLDDAVRAVLVKNKIHLRLGCKERLYLPRTELGRGLHSVELRSEHMLLQLLECLKKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDYSRWRNKRNIRPRNEAMFCYIQDRNVFWGADGICQHCGKSGKTVDHLATRCEKMLGHDYTRLHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDMKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIILYVMTWDGIVTKYHKSHLKRLEIPMNVDAYIQSIVLKKTVEIISFDRRRGLESGLNAEESGRERPWVLLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW35</accession>
    <name>A0A4Q9LW35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0578p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000578">
        <property type="protein sequence ID" value="TBU12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0578p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="544" mass="64741" checksum="B76EE406603577DA" modified="2019-07-31" version="1">MENFFSEKSRIMISPLNIAIFKYFLEEKILYNFLNLLFNAIKVRKLSFNCLTTKLNWNQTKFTNLIPFSCIEIEISMYYLDNSFIKYIYPLLSRFTTKKFKISVTEICLKTFEIIKILHNLQILCISYDSNTQSDRILKNIFQLPSYMPTTHISLTLSDSVLKDLYSFPSLLDNIKLRTFSFHLKSLKSISYLIDEVYRKFNLNFFFQTLAVRSKSPLKSSEYNTLKKFKFTKSFSCFFDTNTIRNCINQEFGFLSSFVYIKRIRISNIIIKDELLRFIFHSKSLKSVQFDKGTISEAMNSCYHFENDNLCLENFFIGYLDRPFTKNLLKYLQNFRKMKSIKISAYDLINGIIIFNVIFYDINDKILEFFDPEFIFEDYLYIKNLSMNRIMFNSDLINGIFSKKWNLSKLRKLNLEEMSLSKPDMIFLSSLVSLLDISFQRVKFLDCFFGDLLSHLILKKNCRLHLSEISLSKSDLIKFSHLKNLKYFELCFCSISNENLFLLRHLYLKNLNELKLHVTGLTRCCRFFYKEFFAASILEILYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW54</accession>
    <name>A0A4Q9LW54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0701p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000701">
        <property type="protein sequence ID" value="TBU12597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW54"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0701p0020"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="211"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="470" mass="54285" checksum="85015EDA50ACFA2D" modified="2019-07-31" version="1">MKFNTLYITMPLLLGLIGVRLTVLFVLFYLYVCKKPSVFYVKTARNFFIYENTPSLSRRFYPFILGFTPHVQSFFGGIRSKGRNPDQCLKIKAKDGCILTVDVFEPTNNNPYYTSKEWGVNYKGEDICVNKGTKEEGVNNSTNEQQSFNKGTTNLHPLINSTNTQHPVSSSTDEQHPVSNTPYKQHPFSDNENSLLNIKPFNYYDSSIPNNVILVHGFNGSSYTSYIRNLALHLSNENFRVFGFNARGVTNLLESTTFFHIGWTEDLHVLVNYIIDNYTGYISIIGFSLGGAWTVKISSEITNPRFKCGVAVSVPLDFIKIKEYMLKPVQRKLYNRMLTNKFKQYFIKNWKVFEKEKFKMKDLLKCQTIQDIDLYFTSKVFKFKDLESYYEDFSGKKFIPKIKIPFMILNSVDDPLIPEFSIPKKKCEENENIFLVLFSKGGHVGFLGNNFYKTYTEEVVVEFLKAVHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD2</accession>
    <name>A0A4Q9LWD2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0570p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000570">
        <property type="protein sequence ID" value="TBU12964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0570p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="50893" checksum="C1D78D87FD4D18C1" modified="2019-07-31" version="1">MKPECKFFQENRCKFGLLCKLRHLTRTYLVDTPVWILSCFQSLYMFDISIEEVRNRFYDLKMSGQLEIFYEEFNTAWKTNFIEMCRCLIWLSQESDIISYTDRGINILYDLSQIINSYPNLDNFQLNSLVEELKKQPFSSSEIERFNKVGDRTDKRIKEEKILNIFGDKEDSLNKNEKRSDSFVNKGNYRNDYYDRRGSSRNYNKEYNNERRGQGRSYYRDGRGENRGDNYRDNYKDNYRDNYKDNRDNYKDNRDNYRDNRDNYKDNRNIRDNRDSYKDHNKGFGRRNDRKSSSFVEFSGNEKKDFVRKKEGRILTSGGNEAYRERNEIYRERNSDGVSGKGDFYRSVGGSENPSLVNSSASVNSTFMQNSFIYERNTPFSQSETNLRGEVMGGEIMGGECEESKEFKKKENEKKFTFGNFPYQPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ6</accession>
    <name>A0A4Q9LWJ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0553p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000553">
        <property type="protein sequence ID" value="TBU13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0553p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="92113" checksum="7CD7598335EDB825" modified="2019-07-31" version="1">MNMLLNLNAKMLSNRKIYHPWIHIIYAMSLELVASYKYTFNYKNNENTEILFFCEQNQEISFEEEIYEDYKLNFIYNTDSKPSKNERYCFAYRKNNYINFEILDELLSSKQFENIYENRIIQCNFDLSYFLKFTNDITEIPERFNSYQFKCISTTLQYLKAKENNNLIRFFQILLLKMDLNLTKNFKFQEIFDSGFLNIIDCYIKFNLILAFLSNYMIKYSCIAGNIVLVDSDRESFDISLFNEYIPYKNLLLNNHQVFCRLENILKDQNCLNTFHILLNEINVKSLIINSNHLMRSFYLGSRFSILSTDNWKAITIANSICSFSSFLSRLNLAIKKNIEFLTLKNVSTHRTTLISILKKYEIKGLELIHVGVFENFDYVEDYIKFNKKIEYINFGNVGTHFKWWQSIFVSTNIQRIILSFSSFVAQKNFIKEFCKEKSYTHIKYLELMFCHRKLLAEFFDSLSAFKSLQTLKISGFETDENTEPLFLKAIESMNNLEHLTIQQHYICANSYNLLFRDRKLKTLHLENLSLGIGILQIFFFNNYTSLTKLVLKYMNISQVGLTDIFKLENLSDIRLECCSFHLTAKYNGLNFMSRKIRVLNLLGSHIKAIGGIKIFESVDSLEILDLSKSGLMPGDLEDSSMKWNSSLKSLSLKQGVLDIKNLNRIEKFEVLERLNLSKCVFIHCFFREISNYCRFFNSLNNLYLRDVDIELEDLRYLKKFKKLKKLSCRLSSLYLSTATKYIISLSLYEFRTYMIDGDENFDKLREYLQEENINYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK4</accession>
    <name>A0A4Q9LWK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0523p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000523">
        <property type="protein sequence ID" value="TBU13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0523p0020"/>
    <dbReference type="OrthoDB" id="2188950at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="14123" checksum="E9ED4174F5F7AFEC" modified="2019-07-31" version="1">MKNDILEKLCEMYIKDYKIIKKEFDGFYESHISKLKYFNDHMVEIYKYAFIYFVCDVKGGKNKYCKRHLISKNEFENALKETTCKVRKIEANIENRNRKYETVCNLYSIMSSFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL6</accession>
    <name>A0A4Q9LWL6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0897p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000897">
        <property type="protein sequence ID" value="TBU12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0897p0010"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020653563" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="432" mass="51678" checksum="5EECB63C41EAC1D0" modified="2019-07-31" version="1">MKIFGWNVIYSLMFLYVVMCTKSKRDHNYVLKKFSKGLSNHGYYSGKFIFAGKYSYVYCFKYVLSEESVGIVIPRKQKHGFRFQNKSDISNIIEHENFWKVKATLQIKRRPCVVMPIYENNLYSYIPTLDVFDVKKKEIIKQILDALAYLHHKDICHNAIDLYNIFIDKNEKIVLTDFRLSYTAYRIRMHVFGSSLEETKVKYCKIWSGIKVKQKHGTKTDMKSFGYLFLSMYRDPKQRGKTEVFNLLDPDYKHFAKYFLRKPRKRLSAYGARFSSFFDEIYDFVFCFCKFNDFDIGSKGFQCKKVESRFSVKGNGKRFSIYCKCSEISKELFEKRKLEIQHQNPYWFDDTEIEKFKFSQASSFAVKTNKIIRLLPELSHSEYQAVRNIFFTFLSERSCYKEPRITPEKIIKENKRKEYGDEGRIPKRIKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP3</accession>
    <name>A0A4Q9LWP3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0509p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000509">
        <property type="protein sequence ID" value="TBU13179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0509p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20773" checksum="0A1793B803E44706" modified="2019-07-31" version="1" fragment="single">MKVKKNYSNNLFLWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS0</accession>
    <name>A0A4Q9LWS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0501p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000501">
        <property type="protein sequence ID" value="TBU13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0501p0030"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF154">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="194"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="49012" checksum="80E9F21967522085" modified="2019-07-31" version="1">MDEVWIKIGNITSLTVEQLQKMFLWMYAEGKKPSFVTSLNKQKLKSTNLFFIDEKIEIKIIKKKFKLRNTAYMQEKFDINILIRTLFRKIERNAKPDISLITETEVEKFCIKNISKIYVEDSTFVKNSESVEDISTVENLSKNKNLLKQNEIKNENKIDNKILILTDESENLKLEEYLLLNKEFTIFTDYINNFIVSIDCEMVKTSYGKEVGRVSILDNQCNVIYDKIIKPEAEIMDYLTEYSGLDKDSFEHAVSFLEMKNDLKKIIGKNTIILGHSLFNDLNVLKIYHDRLIDTSHLYKTKDNYKTSLKNLSKKYLNKEIQSKSHCSIEDAKVCLELLALKINELKDLVENDSANINYNTQINIISIFELSNYIEKRNINIIKCSYEDLDVLDCDISKKNDCIFMFFTRGNSHVVCCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT8</accession>
    <name>A0A4Q9LWT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0496p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000496">
        <property type="protein sequence ID" value="TBU13229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0496p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="51203" checksum="9D60F3D099816B43" modified="2019-07-31" version="1">MEIYKTDRKVKKIVEQMSGDLVAEKNSVWGAKEYEDIEITNQNIYKAISDSFSQEDKSDLELLQGLKILPCENNEIFKNMSKLLSNARFQCFSAFFLVLKCKNFSENLENYEKKNSVYSNISSNFTESFINDSKIEARKLEDELGCGLGINGYYEVWRRILGPIPDRILNEGYIFKDMCKLPRHLVFYQDDPIDSSFPRVFLELFYEESELDNIKGLYIFMKGIIKEDYQKYFSAVICLKITCLKGGIFKSNFIMEIIFEFLFLADVLKTELEKVENIEKIKKNRSLFVDAFKKILDQKKIEYVKGGDSDFLDCSKFPKTAILLEILCYIDLFSNDCFKGLLNTQIHKKLKEEQKSMNEDEDVDKREWDYLIHVFEQEISALSPQELKFIFYTPVIETKKSKTNSDLKTIIFWIVFSIIIVSVIFIAGYWYFYRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP3</accession>
    <name>A0A4Q9LXP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0390p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000390">
        <property type="protein sequence ID" value="TBU13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0390p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="18608" checksum="659A2BC4AF576190" modified="2019-07-31" version="1" fragment="single">MKSKTILYIFLGILLSIGGIISVLWIIYNEINLVEKEVIEQLRKDTIYVKNKFDNQKEYSSHGSNCFDISPLQTKIISFLKFTNDQIIYITDQNYEKNDYDAILFCTDSNIRYLNDLDKLKNERVKRFFLEKFIYNIECQSIIGLKNSYEPHYKSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR3</accession>
    <name>A0A4Q9LXR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0383p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000383">
        <property type="protein sequence ID" value="TBU13599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0383p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="795" mass="93935" checksum="D4D5A50E23660C2E" modified="2019-07-31" version="1">MYFKSRKLRILTEKNRQRIFWGLIIYICSIYSTAVSFFVINDKSCIFDFIANDSILETSEQQNNSVNSIHAEEKITFLKNDIIRVESYNTNPKFYNSYIVTIPYKDSMLLNSKYIKDLFVSNAKNIRICLKNVSYTGLLLFLKLIDNPDVSINQMKIQDFLEILMFLTILDIQKSKERDGFLKEILRNIIFSMANINSNFDYKKYSENRRYESIKKCIFRDLFIFFIDTVTFKTRRTQNFIVLSEIAALSINSPYIYFSSKEIPKNNSISKFYLRFEANDIENISKIIEQEYLINTWIFLNKIANIDILYLIFNEKSAYKKAIILFSNVTFHAENLYIYSYENPIKLFMNKNVTPFSKKLKVLKLKCNFTTEEIRKLLNVCKTIGEITLKTIILDFERLGLLIDFFIKNPDKHCKVFCTTYIFLGTTIQFIRKLPNNLSLHAINFQKGSDIVNISLEYMPFFQTDKYCYIHTNNSIIPNNFVFLELSNFKNLTLNYKHCSSPYKLDCNVFTPLKYLKTVKYFTLQNIVICDELLLYFLESNTIVLFRVIDFVCNYSLKFLENNDTYNRKLESINFINSLSYFDFGIMIYLSRFQRVVGLKLIDISINSLKIYLKSIFNNILGSKFKLIHQIYLLILKITTKSSTKEKCNIFELISETYEISDLVQIEYCVYEITETDYYFFSKMKNLKVISIAVRNRSKIIEFCRLLYNYEPDITINALYINVSRIQKNDIEAFKKLNKLSVLSLLCDTIDYETVSIIKKSDFKKTAFIIRAPVRANRSVEINTYLDSEFRNNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN4</accession>
    <name>A0A4Q9LYN4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0550p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000550">
        <property type="protein sequence ID" value="TBU13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0550p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="20201" checksum="D6E6B00F67BE1D5D" modified="2019-07-31" version="1">MSFEEIESETMLLLLERKLIFNSDKKLSVYQFTNDIQNKFIQNLLCCNLNFKTFDDYLKHVYLTHKEYKAGYEDQCVGEKIREYVGGNRDNLCDIDYEFYVRILNKYKMYCCTTKGCAKRYTSAYGLRYHLENGHSSYRIPKRFLCTFNDCNKSYKNANGLKYHLRNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP9</accession>
    <name>A0A4Q9LYP9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0588p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000588">
        <property type="protein sequence ID" value="TBU12910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0588p0020"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16071" checksum="FE47DEAF0EC2E04D" modified="2019-07-31" version="1" fragment="single">MCGIFAYANFLTKKSKKEISEILTNGLRRMEYRGYDSAGICIQDNSNSRYSVFKTPGKVQSLVDFVEKQNETDMESETTNHVGIAHTRWATHGQPSERNSHPIRSDPSGMFIVVHNGIITNHQTIRAYLESKGHVYESDTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ7</accession>
    <name>A0A4Q9LYZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0570p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000570">
        <property type="protein sequence ID" value="TBU12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0570p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="369" mass="43828" checksum="C53FEBDB7EC4B8FE" modified="2019-07-31" version="1">MHISVATKILLFFFSSYLLKSLLIKWMTNEINRYGQRKSFFQTTYNPKKYTRKVEIKNENLVVYDSFKCIAEIKHEEIPKDSYLFNLFLFHSFKEGNIYDGNIRLDISKDVLRIYSSNYTLSPTYTFLLREKPNLTDKSFLDGIKELESLIIFQETFQRKNENETEETEKDESEKQKPKMPKIPENSDLNKKSPKFEYVNQENEKLLQTLRSLIYLGLNGCFTGRVFVINNNSINLYHQGKSRALIFIPKEYLIEEFKKLKAFEQIQKYFDENIIFLFLPDQIIIRFVSVENDATEYYIALDKRKVLYKPFLIFFNKRIKDVRVEKIILKYYNSCIYTLNVEGSENSFSMIQDALNSEKTSAVKSNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ51</accession>
    <name>A0A4Q9LZ51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S proteasome regulatory complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0500p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ51"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0070"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="196"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="390" mass="45397" checksum="D7D4CF8225F08027" modified="2019-07-31" version="1">MLNELKNILKSKTHPTDEKEEAALTISNTLLEKKLYDDLGTFLVTIKTYWSDISIARYTKIIKNVLNYFPSKQEYFLPRYNLLEKLVEWSKIENKKTLFLDLEIKRIESLLSLKEYSKCLECISPILKELKKHDDKAGLICLYVYESKAFYEQKNLSRARSSLTSAKALAVNTYVSPVLQAHIDMLSGIYLCDERSYSNAYSYFIEALEGFWQGKSFEDAIFVVRYMILCKIIDKKWNEIESVLKLKQVSYFVADEIILLLLKINKACSERNLKDYTDVLNTKGELMSSDTFLISHLYFLYDLLLEANILKIVEPYSNISIDYIADQMGFEPAFIEERLRKMILNGGISGTLDHVGRSLLLFVKESNEEFNSHYLEQINLMNQYISQLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZF1</accession>
    <name>A0A4Q9LZF1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0219p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="91681" checksum="462966F3361DD128" modified="2019-07-31" version="1">MNYYKLKINKIFVTLLEFLIVLFNIFPKCHCNEIYESSFIILESRICFYNFQVIFNEKKYTYGVRCIFDTRNEPENIRNLSFICIYNDRNYINFDYLDALIVDNILNMNISGKFLSKFNLIYYLKITQTNDSFIENLNLKDLYNLLLVLDELKAKQNKNLKHFTLAVVFRLIYGNDFRSNLLLFRNKLKKICCINFYIANQVLIGFFKFFFVNISLFEGNFVASFSKYENFKFKPKNFLPENIYFAIIGNEIIIKVERILSDKICFIFFQFLSIKMDINHLVLKNIDLGDDNISRTKFKIFKIESFIIIKIWNVSGYSSHFFSKLNTAINSRIKFISLETFELTTYEIETLLQDNSLISLEMNYKIISNSSFRLRNFHYCNDTLRILDLSNVLIENEWWLGLSNKFDLKILIICSFDMIFLKNIINTMHMWLFHERLQRLEFDELSYDSANRVLNKIYLFKSLCSLKMHSMYSVLLVITDFIAFIYDLKNISEIDLMYVNLTKNALQILSTMKNLEKLSLKSSYLQITNILGIDLSFFYRNIKYLNFSNTMIGDIIFGVIKDCESIKYLNLKRSKFNLKCFQSLKIFKSRQTIEYLNISHTDFGVNRDVSIFLNYINLKKLKLHNCNLSCGFFKINPFKEILKSIEYLYISKNSLNLNDINIIFSLRNLKCLDISNCTFKDFNINSIILRLIIYSPNDRNYSDQNFSSKDKLLYFYHFEELKPIIILDLNKHNGINSKIFDLFTSKGIIQNKYYKIFSNNIEIIVELEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI7</accession>
    <name>A0A4Q9LZI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0222p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000222">
        <property type="protein sequence ID" value="TBU18895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0222p0030"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="196"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="32829" checksum="E16A14ACD42A7B94" modified="2019-07-31" version="1">MKSPEKLSKNLFIQNLHGKYNKYVNFKLDKNIFYNDEDKYRSTNLNEFLIPDIIVEEHIVLRKIEARNIYKISEDFNTEVIILDEDVEIIVVAIKGTKYNIRKTIEELFKRNVEKYNFGVEKTLEIVVSREKWGYITGKNGNALNEIQKNTSTKIILSKASDTENKIIVITGNEENCFQAKEMILSNIYFSFSSQKQNSYKIIIPEKMALYLLARKAEEFKILQVKVPSKIFIEPTYISTNDTRRALVISGNYENFKKTKETILEYFKDKISLNDIEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ7</accession>
    <name>A0A4Q9LZQ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0329p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000329">
        <property type="protein sequence ID" value="TBU14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0329p0010"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="80"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="532" mass="61775" checksum="E84DBB37A80F3689" modified="2019-07-31" version="1">MKEKLKTSQNEHNKDKLDYFDENEENKIINVRKKALNIKTKLEKISSVEVEGAKQVVEKFEQKLRIEWPVLFGENPKFIFVYVDLDSFYASVEMLKNKSLHNVPLAVGGNAMICACNYKAREYKVKAGMPGYIAKNLCPTLLIIKPNMEKYNYYSEIIMGILSKYDKNLEMYGIDEACLSFDKDSLNTAYNILSKKTDLKKKIDFENSCVLFTFENICKIVEEIRNCIFDTTGLTISAGISVCRGLAKLSSKVNKPNGQFCLKNNFQTYLNDLDVDELNGIGKRTKELLVRTFNLKKVKELQENIHLLYLSLKMKTFNMLFRLSYGLSIFDGLRPVSYTSLSKKSINKEYSFKATNDYIEIMNNIYNISKYVSKKMQKNNYLSFLISVKIKFSDFNSFTIQRQCKVPIKTIEDIFDTVIDLLTNHFSDKSIKQKLYESICNVNTIRLIGIKVSSLIKEKNFNLIQKYTNDMVICSERLCPICNLGFFNESNFIFESHVNICLDKQQTEKRNINRTLLKFFKSRNTEPNEKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT5</accession>
    <name>A0A4Q9LZT5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="13">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_0402p0020</name>
        <name evidence="15" type="ORF">CWI38_0428p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000402">
        <property type="protein sequence ID" value="TBU02863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000428">
        <property type="protein sequence ID" value="TBU13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0402p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0428p0020"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU02863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="216" mass="24998" checksum="68E026973257BCDF" modified="2019-07-31" version="1">MILYVVFDTNLNNWRQMKEPLQIFNDIIIFLNAFLLSRPQNRIIIISNMKTIYDSKYTSLLTLLEILSDLKSAPSNLPQNIGYTMCLSQQQESSRILIVSLSLPNKSDYLKYIKLYFTSQKLNIRIDAVSFPKSFVFEYLASSNHGKYSSNLNNLLDFLFSLLGTKKPTENAYFQVTCVCHDKIILYGLVCPICLTIYCKFVPVCKKCKTKFTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M010</accession>
    <name>A0A4Q9M010_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0175p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000175">
        <property type="protein sequence ID" value="TBU19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0175p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6192" checksum="BEAC4EB1FDF2299C" modified="2019-07-31" version="1">MNIEAYIQSMEHKQPTSPLNQVYNEEDGVKTENTKNNTPYFRWHNHRKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F4</accession>
    <name>A0A4Q9M0F4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0091p0050</name>
        <name evidence="3" type="ORF">CWI38_0140p0040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000140">
        <property type="protein sequence ID" value="TBU20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0140p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="50489" checksum="2A2C69FD6627DF79" modified="2019-07-31" version="1">MQILTMKRNLLGSAIVFMVMKFSESRLSYNSNIEYMTTRIIPFLPHIIMCMKGCMATSKQPAEIANERVESHYIEDNYCQTSISFYVSYFILYFCDDRAKEKERRDLVKECLISKIDASGIAQPRKDEIIQRFENIWNASSVDNHESDFYLAMDYVLIKIALEAEKYIVNEILSIKSMSATLLTHYFFKDIMTLKLMLAEKMIEMAQSEHLCPCIRDPNFFESTALRYTDYMSFEKMCERYLTSIPSVDVNVLMLFYDIEGEFLHEALINMRSEIKENIYQELAEKDVMVECFADLFLSDINFTTTELNPGSTFPNEKLKVITKDAGSEIYNFVSPIILEMIGNITGTRGFKNIVSGAVTSIQREMASKEYKENLSQHLNDYQAALKELEKTLEDTAVEKMTQAFSKANPSKDEISVEKKTEDEGQATGEELVGAVGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K2</accession>
    <name>A0A4Q9M0K2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane-bound O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0349p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0K2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0010"/>
    <dbReference type="OrthoDB" id="2189411at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42713" checksum="8D87CC983A204239" modified="2019-07-31" version="1" fragment="single">MNKIVEMPEFRYILALFLTYFITFGLKLTKRTNLFPLFSLCCILIAFGIIDVIFFLVVVFSNISALYLFKRTERIRFIMTGSNILGLLLYQQLNNFIKGIYGERLGPNISGPLMMLVIKMYYLGKEYDFSTHTIYNLISYIFYLPSILVGPAPSFKGFIERPKQTKKYILFSLRVLMESFIFMGLHLLIRSKFSVEKMLEMQKSNFFKNFLFLYVFSFGFRCKYYFVWTFAHSVFSLDGYTNQKNIFPLSVEFSTNIKGVTDSWNICTNKWLKDCVFVPLKGYSIFMASLATFFVSAIWHGLNWCYFLMFLSFGLIIPFIRNNIRIYKKYLNDSICKFVCLFQMMAIVSYFSVPFITLDLDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q1</accession>
    <name>A0A4Q9M0Q1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0211p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000211">
        <property type="protein sequence ID" value="TBU19449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0211p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020413433" evidence="1">
        <location>
            <begin position="19"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="91419" checksum="32C20B623EBEAB9C" modified="2019-07-31" version="1">MNILAADFLLNLISFVHIFCSFNKVSLYQYSYTFETKNCSDIIFFSDEQRLKSSSEKNDVEFNFILLNNKSLPHKRKTHVFTHRKDNFVSFQILEDTLNSRLSPNQNGKIQCNINLAFFLKLTKDITAIPDKVNFDLLLGVFSILKYLKANYNKNLKEFIQALIFKTYLNLENNSSKIEFAYSKEYAMTNIWSTLDFYIKKEFILAHLKCYIIKYIYNEGNLILLKTNNEKFNTSIFEEDIPYKSLLIKDYKIFMLLEKILKFPEIFNAFQILLNEMNLKSLILMCFTQDEISNNKSSFLIFSLNSFKSIMLYNVQSSSSFFLRNFIAASEHDLEFIKLENVNIPTNVLYLLLQQTKLKGLAIKNISIPGNLPLLDQYMVVSERFDYIKFQNVKINSIWWNTFFSKAIVHTLITSFNSISAEKYFIEEFNKVSNVKNFFHLEIIFYFAQISKEFCDSLCKFENLRTLKLRRYVLDKQTESNLFGAVMKMIRLENLTIQNYHISNTTQNDIFEKKGLKTLHIENEKFMKIFFRVEFKYNFESLNRICFKYITIERLCLIGIFELKGLEYLSFDHCYFEPFANLKFPNFRSRKLKFLYFNRTIIENINSVDFLNNLDRLEILDLSYSRSQLGYLISLNLMSNKTLRILLFEAGILGTRDLHRIKQMEFLEELDISYCEFSECHFFELSADCKFFNSLKVLNLWYVEINCEDLRYLLNFKNLTKISLTFYNHNHMSEKDCLICIMQLIRSSNSRLEVSLNPNNIYYRYVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q9</accession>
    <name>A0A4Q9M0Q9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0236p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="16356" checksum="9C4EFE8429B6423A" modified="2019-07-31" version="1">MNEENYLSLNLFIKNEIIDIYNESIFKIKCKSNVKLDAESSFKYLSLKNQKYNKKNMDYHMDSYNLLLKYLNDTTDLNYIFNSNFNRIFSVEKLIEKNYEKILNEKFLCLSNQIGKKRNLNTNELLFMVIFSNLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z0</accession>
    <name>A0A4Q9M0Z0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0218p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000218">
        <property type="protein sequence ID" value="TBU19124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Z0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0218p0020"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="268" mass="30553" checksum="6D0DE91822648006" modified="2019-07-31" version="1">MFELKITQAADDKTVVGGRGNLVKRVLESLADLVDDVEFKVSDKGMCIQTMDSMHVALADIFLSRDIFESYRCDRSLTLGIKLKEFLKILRNIKMENNSTFMMYCDDDATKLIIVNECEGFSLHFNLKLFDFEIESYNMSDVQYEAEIEMPTSRFLLLPKIVGTFAEYIVFEADKDKISFSQSGEMTESCLTLKPHQFTESESNSFSVTSHVKKEVAMKYLNCCAKSASLCERVKISLGNRTPVFLDFSLGDLGYIRYYIAPKDDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M134</accession>
    <name>A0A4Q9M134_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0332p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000332">
        <property type="protein sequence ID" value="TBU13818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M134"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0332p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020677967" evidence="1">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="502" mass="59816" checksum="702BFD3A07DDFFA5" modified="2019-07-31" version="1">MNLLFLSLILLFCLSKASNLANPLDIDTSGTRNAMNNCKESNKSKDIETEECLNVILSNIPFFTISFVLFCAPKFGNFYNLFSEFFLRKYNALLNDFYCFTAFTEYDLYYSTTKSILRYFRRWIINEAIDSKVFDGNENNILNEILMKDDIFEKYLEEVVQEKREILKWLENMQIFYYKEDYLEILRNSLHCIEFSRFIRTESLLIFKEIFILLFVINNSSISILSQECPPECNDFKVKENYFINILRRSYNRNKWKSLKIFQKREICERIDSNTLILITGLDVMCKIFSDKMDPNNLNKNTFSRICYLKGTVYPTLFRSNEIKMYLPHEYDQNFIEYLQKFLSKSESKIIFVTLFFSYTDFIVACFLKEILSKFGEKEFYDFFTSDAVKTNEYMKNKAFNDTIHEISTKTSIYEEITTYFIHLSQSMKTQLFLKVSIIKNEEINFLKIFDDILPSIMSWNLRNNIRNDVFNSKMTTVFLYSLRCCIKQSIKRIRVPQCSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z9</accession>
    <name>A0A4Q9M1Z9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0250p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000250">
        <property type="protein sequence ID" value="TBU18158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0250p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020654322" evidence="1">
        <location>
            <begin position="16"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="683" mass="80321" checksum="22821948AA35BF57" modified="2019-07-31" version="1">MHIFVFLYHIYIFLAEIKTSPTRKKARTDATEDVSCDSSEHGITTENFHCCGFEKKFSSGSEHTELNKRKKETEKLLFEGEGSETSTNIIDHDILRNRSISLSDNSMTSDKPEPKNPLSHCKEESLLTMGYPEQSSKDHSTPPHTKLPSIQTVFPQKFYNQQPIKPYLDELIPQEVVLQLHEIPNKIPPGLENLANDSTKDECFYEKFSYTNTTDPYPSYVNRENQNSEIPSNLRLQQENTVANNQKISAVELLNQNKTKKHKIKYKSKSIKSITKLYSDITRWKCTSDDLEESVLVLQQGHGAEFEEQAVLPNFKSHEPVILTYLKNKNSNFYSNAFIKENDFEVFSKNCKIIVKFEKDSYLNSSTSEIMQNIPDYDLSKYSKELQSIQIHIFVPELNYILELFRNNNIESILRGHVLLVHYQYEIIRLLKNLIFEKNEEIYKRPTNEFERKILFSKNKTKTNLMHQRIFFLRILISDLFSSFRFDTKKIEIYRILNLIHHCSVFYGATQSYFKKTCFNLQVRFIFRFIFDSGISLDNYENDFMEVIKAEDQNQNIFLQLQNRFLVLFNDYFCNAIYIDKVLNIIDTYTSYISWKNKEFKIVKKIKELKSTISNIKTTECTDSNKIELTKIFLELEYRISHIEIKVLSISIFWIPSYDKDGYEMALIKIKKVFEKIIIASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B5</accession>
    <name>A0A4Q9M2B5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0018p0110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0110"/>
    <dbReference type="OrthoDB" id="2194473at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16487" checksum="BA9A76E9A8670745" modified="2019-07-31" version="1">MTDGPRLNKLKQIYTKAIQQTTTNTTLQSDLLSLFKQHLSTYNVSTKLNLLDTLISNNHINLRDISSSSYIKEVYESYIVDDKSNFISYLNAQIEKVKNSKNDVENEVSEINSQIKEYDLKINELEEESKSVLEKAEQLESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F1</accession>
    <name>A0A4Q9M2F1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0212p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000212">
        <property type="protein sequence ID" value="TBU19443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2F1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0212p0010"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="141"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="288" mass="32923" checksum="678FA53FBCA01803" modified="2019-07-31" version="1">MCKKIAKYMKIEIVPIYGGIDLHDDILRLTQGVHVIVGTPGRILDIAERKIINLKLCNILVFDEADKLLSFEFKDSLDKIIKFLPVDRQILLYSATFPSSVCEFVNSYMNKPLHLNLMKELTLKGVHQFYACVEPKNKLFCLKTLLKQLNFDQCIIFCNSIQNVELLTKKTTEMGFPSYFIHSKMMQADRNLVFHNFTEGGCKILVTTDLITRGIDVPTINCVINFDFPKTTESYLHRIGRAGRFGNYGVAINLIGPSQNLRDLENALDISILPVSDKKFEDFMKKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H2</accession>
    <name>A0A4Q9M2H2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0082p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000082">
        <property type="protein sequence ID" value="TBU20377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0082p0060"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="27917" checksum="35F993432981A644" modified="2019-07-31" version="1">MMALIAQKYYGIPKEYIKEYVKECEACTNIYKSYYQKYDLFMVDYVDLMGYADQNDQYSWILDDIDTFTKHLWSVKLINKTSEYVNHLLKFLFDNFQVPVAIQSDNGQEFKNTLLKTFLTDLNEDINNVVCAYNRRIHGVTNKSPFMLFFGQPGFNNPLSRSILVKNEPSTIVPAIDIDPDIVLDLEIASDVHEEFTETVTTTTTVIAYDLEIDSKIRSDVAKHFKNYRERIIESNKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2V3</accession>
    <name>A0A4Q9M2V3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0001p0160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2V3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0160"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU21045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="16853" checksum="362FE8AEA20B642C" modified="2019-07-31" version="1">MENNYYPKLFNTGQKEKTKECGETKEEDSEVPLLSLEDETLLSRNPCTRRYVTVFGFSLQNSDYVISQIKKCGEIKRIEYGKNWVDVEFEYDYEISKCLALNNIKINGEIIGCFRNGIHVAKTKDVFSTQRKGLIGRILEYFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4A5</accession>
    <name>A0A4Q9M4A5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0049p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4A5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="11825" checksum="2D40233E99C8A774" modified="2019-07-31" version="1">MINKQEVYKKMTVKYSKKTKDGNVEYHTFDKPGAFNILTSEPEKNKMNFSASHGILWKTTDILLTEDTTIFYNIETALSILYELYLLYQQFNSEHAEFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5D4</accession>
    <name>A0A4Q9M5D4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0023p0100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5D4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5D4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0100"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1112"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1155"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="237"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1205" mass="138989" checksum="4E5BB506ACCF6161" modified="2019-07-31" version="1">MNESTYQKNDEEFLIIEGRKRRIHKVVYILLCVFSVGIFYLICKYLKKVKLVLETKACKLSEADLIFVTNHYGNIDISEVKTIRFTGESENLKKYVKNNQIKMFESQFYRFILDYTIGRYVIPTEQNIFLYESTFEDIYKKNLKTSLSKLKMALLEKKIIYGENETSIRQKTTFEIFIDNILSILFVYIMICVILWVNIDYKLYASIIFLLSLYSLVHDIIQEFKNRKIIMELAKKKRMVIALRDKKWMFIETKNIFPGDLICIEPTKDFHSDVRVLKGDVIVDESFLTGETLPVFKSNASSGNIIYSGTNILKSTSEKNYIRESLELNFEEKHIGDSNKFCRVKNVGLKRDQSHISESEISSSQKLTAKTKLPVQIQTLNNIDKDTIEKLNCAIGVVVSTGFNTSKGRLIRTILIPRPPDFVFYKESMKFIIWVFGFGILTSALIVIFFLLNSIELLIALKYSFDLLTCILSPALPTTIWIGATISAGRLKRMKIFCSDLERINSAGRTNIVIFDKTGTLTEEGLDVHCIDNFQITSDDIGKFDRQMVNAISTCHGVYELNGEYVGDPLDIKMLLFSNSKIEYETFESVSIRKITIGSSFNEIKGPVFRENSGDETLFHYSKNPESILPLNETNQTDYININDENINNRIDVYIDDGYEIPFDIEQEIPRKIIKCYDFDTNLRRMSVVVVDKGKHFVYSKGSPESISKILREIPEDYEERVREYTLDGYRVLSIAYKETHSININERLRSKDEYGLTFLGFIVFANKLKPVTESVLVELNEAGIKCVMATGDNILTAISVARQSKLVDKYLPIIFPVIDENAKNIYDAEWLCVGDEELTFDKIRLTLFKDLDEISYSDFLVACEGREYEFIKKDNSTYFSFILSKCAIFARMNPDQKKMLVEDLADIDYSTCFCGDGANDCGALKSAEVGIALAQNEATLTSSFTSRITDISSVLTVLKEGRSALVTSISRFKFVFISSFIQYFSLYILSLKFLFLSEWQTMHYDLLIVLPIAYAMTQFRPSKILSRSTPYAHLISKKSLIPLFGSVFINGIFLLICLFFCVEPNQDFEKFTTLSSEGTAIFFVSIVQVLVSGIFLSKGRPHREGRFKNRIFIYFMIFSFLYCIFLTLCLQNIIFDFIANFFRNYYEFWVGKQILFKIVLIISINITVNFIYENVLSKKLENFCQDKMLVPKYDRIQEEFTDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5D5</accession>
    <name>A0A4Q9M5D5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0022p0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="11639" checksum="825F3DCD0CFDB8CD" modified="2019-07-31" version="1">MSLFEIKDSIIKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPSLKEEKREEDAPLISQGGTTLEEPTSNINKESDLEEETEVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW46</accession>
    <name>A0A4V2JW46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2538p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002538">
        <property type="protein sequence ID" value="TBU06612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2538p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15502" checksum="95A8B2602095B172" modified="2019-07-31" version="1" fragment="single">WDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL2</accession>
    <name>A0A4V2JXL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0869p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000869">
        <property type="protein sequence ID" value="TBU12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0869p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19950" checksum="87E1E1018E52146A" modified="2019-07-31" version="1" fragment="single">MQFTSLLFFFSLDKCSRRLIVDRKKVEHVLNDFVSMIHIERKCLNLSPRNTNSHKVCIANKYISDLDEINDSKKISKEFYEATNLTFDEKFSKDSKISSKEYFCNFQSLIENDCLDIKSFMTNRPQIFKVFGGTNPNTLEWPHIAHTEQLKSFKRPPPPKKKHLKQQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP5</accession>
    <name>A0A4V2JXP5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0691p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000691">
        <property type="protein sequence ID" value="TBU12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0691p0030"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="666" mass="78232" checksum="FC3BAE098EA4A811" modified="2019-07-31" version="1">MDFGEECPICYSEYTNTGGHRIVVLKCGHLFGLQCIEVMFGRKKTILCPLCFKPSRKTDIRSVFASKIVAYDSEKEDSILKDLFEEKKIKAELQEENSRLSSNLYYIQCEMQRLEKEINLLKNSSNESKSEEYRLKRKFKRIKINFKTERSILLCDDFNSYLFITFYSNEGIGIKKYDLENLLIKDVYNLFGCCDEYSFCISDIKVSPYKDGIVACSYKNSIKVINSITGHIINIFSVQSRVYSLCFDRKDRNILYSGDERGFVTVYDLTKGLVQEIMVDTKSLHSIYKSGNIIYCGSINGIFLVTFDEKLTTLFTIKKYDVSFYQGICTNLYGINDLILCTFRMNSINSTHKIIGIENFNLSNDITQYRRIRDKLYKNYIIYLDEKYNKVIIYDYLSEMVVDSFKFNERIIDFNVSYEKIFILTENRGTTLEEPTNNINEESDLEEETKGVKEDNLKIIEKCEDKENGLSYNLVIDCVNDSLLVISNVFFIISFNYTYRSLQKIFKNVIVNTNEILKNILENILENVFRKELYEKLLLKVSKNILDNLLIIISMKILKKTLFEIFESKILKTLSEIYNLNTVKKTLLEVYNLNIIRNINDFNRDIYMENIKEDSIGNIKIENVQDSIKYILAKYLKECRNEFLYEYTGMVFHFKQQSKYFSIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR2</accession>
    <name>A0A4V2JXR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0629p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000629">
        <property type="protein sequence ID" value="TBU12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0629p0030"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="624" mass="71623" checksum="5E4873B005B16E1C" modified="2019-07-31" version="1" fragment="single">ERRGLLAENQLGAVRGVQGAKEQALLNIALNKEYVNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESIFTNHLLFIDDLKLLAKDSSTLSTMTDEAKEFSKVIGLEINKEKSATNDKCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRLYDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLMKSKEISTIRAAILKVENNNKTHLALIKGFLKVNYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVTVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTAVKIRNNRPEIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVEIIFFDRRRGLESGLNAEESWERASMAPFISQGGTTLEEPTNNINKESDLKEETVLVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW8</accession>
    <name>A0A4V2JXW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Uracil-5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0425p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000425">
        <property type="protein sequence ID" value="TBU13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0425p0030"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="506" mass="58833" checksum="19CB8A30E8D11BE1" modified="2019-07-31" version="1">MLQYKISEIPRYATISQLKKSFVKNLKIKVSDFKITYVQKNDFGFIIFKESLSSQQLEQFENFYLKNNVKLKFRRLEDKEDGFFGKKSKEICFQSHNTVSMEIDIRDVVTTLWKMPYEEQLTYKSNTLESFYKNIYKNFISMKSSDTKVRNNCQFSFGFDKNNDIIVGFRGHKFIEYPNLVYNVSNCLNVSENMKNIVGNLNNILQDKKDLVFDRINKKGFLMILSVREFNDKSLSLIKIKSKDISLKEFSEIIDISRNILTDNSFLQISNDTFEGIKPEKNILSKELSDSFLNEIKTKYTQPDETLDISPVVICLKGHPDLETCLLSNFKFKISIFSFFQINTEVTEYLIQKIKKLKTTDTLLDLCCGTGMFSVCLNKDFNEIIGLELSKECISDAHRNIKINGINNITLVENTVEKAKFPDKECSVILDPPRNGVSNKLMNKIKNHIFIKEIFYISCAYEKTLNNILEVVSLIDLPSFKVEWIGGFDMFPNTKNTEVLIYLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY08</accession>
    <name>A0A4V2JY08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0328p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000328">
        <property type="protein sequence ID" value="TBU14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0328p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="31057" checksum="6690999DE112E913" modified="2019-07-31" version="1">MDSNNLADPKENLEISIDDISVCNYDKRVKLSRYFVFLLMFLLELFVTCIFGLFISYNYNFEYLHEIFTKYLIYITIIYMYFLAKNRRNELNISTLIRFIFCCVLNLIILFCDSYLSNIQRSADYINTSEIFNGRHSYGILYFMSFILLFIFYFYSKGIEKIMNTSKSSTLKFCIIYTLATLGLLIENIVRFTYSRTVLNVTRHFIILLVLIFQLVYIVFSLIKKRKIGTVIVPLALIYLYFWNIFSQIFSIHVLKNLLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD9</accession>
    <name>A0A4V2JYD9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0038p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000038">
        <property type="protein sequence ID" value="TBU20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0038p0030"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="542" mass="63214" checksum="36AD9EF1B563D014" modified="2019-07-31" version="1">MSRDFNNEEEKMQAEDDIKEGQARLNSIINTDTVYDYNEHNNFQRNENIKSNDDFYCQDLYKFNGLKNHPREFSNNIHSMDDLYNMESDLRNNLREEINNVDIFNDMYNTNINSINKLDSKSFLCDEFFKSNKNVVESVKNKKKNPKENDLNLKKLKVVKKNAKNNMFILPEKSCKQSNKKDNQSPNYLNTCASYDAEESRNLFSHNIYNKNIKNEAFIPQMNAESYYNINQPNKIQCNYEKDGRYNMVSKNINEFSYDGINLLTPESETTNQNGIFNTVPGTVESYMPYAYPTSFGIGASYPYAPQNYGNYYLHQHSGDANEYGYPARNNKLYSDFPNDFPCYTNDSSFKNIPENGLTYQDQYNHFEKIPYRSNYCSENMYKNSIFNCDLCSKKFKRLSTLKIHIFSHLKSASIYDCPKNICNCSFKSLSLILKHIRSVHSSEKERLTNQVFNSRFLSTFKSYLALNDYYDSDKNLGVNPFIEKFCFGCFTYPKSVDNHPCTSTYFNLSSCPACRCEISKGSLKVHCCSSECKRLKPEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE9</accession>
    <name>A0A4V2JYE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0025p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000025">
        <property type="protein sequence ID" value="TBU20763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0025p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="383" mass="43473" checksum="5BD2E4465FB1E3CD" modified="2019-07-31" version="1">MENLSNNEKAIRMLSIEEYKKYCKNNTIISFSFKALNDNISPDYEPYCMSETEVSDTKESLNLSQIQSENEVRSELIPEENADISLGNSFFRASAALEKRFLNIDTTYEEHFYNSSEIKAKQTNTVTIAKEIDINSVIVEFDRSCKIKYLVMIKNGCGVNDPMDQSNANPMTTDLKKDNQFEDLVIPFKKLTLQDHLSRSENPVSINESKKILSENQLPCSPKQDSRSYDLQNSHDLDDDFVSDEKISTHVNESNNIIFAAKYLGKDQNEDETSYLGLRNVSSIESSIYKNANGTTNDIKIYPERQSLLNSSKSDPEKSDVMKPAIQAMDTGEIEFRHHSHRNIASVGRIVGASVSQKHSDSKKRKNLVLFKSLYESEDTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTZ8</accession>
    <name>A0A4Q9KTZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1940p0010</name>
        <name evidence="11" type="ORF">CWI38_1638p0030</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001940">
        <property type="protein sequence ID" value="TBT98024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001638">
        <property type="protein sequence ID" value="TBU10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTZ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KTZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1940p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1638p0030"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT98024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="299" mass="33981" checksum="8F6413A43212DE11" modified="2019-07-31" version="1">MEFISKIYNYFTSDVETKSYDDLSNELKTVMISGSIYNGGRTEITKTIGRNLQIYTCMSVGDIFSKNSEKSQITAKNVQFGCVMAGNGKILNLLIDGNTLQSRLSLFTRNIAIKYENIISKINGIHSQVNVDHKNKFGAISLKYISPSFPLNTNVFVMNYVKNFYKKLYFGFENILTDVTGKKELGISVIGRYEGKNHISSLSVQQFTSFCFSHVRKFNEIFKFANEIHFSPFTNNFYSSIGIRLDTYKSIVKSEINTNLKLALQIEKKLFEGMIFNIGTEVDLLKNSNIFGFGISYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L220</accession>
    <name>A0A4Q9L220_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox KN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0710p0020</name>
        <name evidence="7" type="ORF">CWI38_0847p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000710">
        <property type="protein sequence ID" value="TBU01437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000847">
        <property type="protein sequence ID" value="TBU12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L220"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0710p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0847p0020"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="132"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU01437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="205" mass="24382" checksum="9238F376EF8DD3C1" modified="2019-07-31" version="1">MNVGSKELFAIIKKMAVIETKYTESSISNHELVNILKLLREEFEAISKTAEQKSPDEKYFVIFLIIILERLKKSIVLETELREIIEKEFQVYMDSLNEKLREVFKISHPYNGTFTYNRMYKEIKSNIHSKDESNRNKRSNYPKQISKVLQNWLRENVNNPYPTEAEKIVLSDKTGLDQTQINNWFINARRRLLPHMKNTHMKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L420</accession>
    <name>A0A4Q9L420_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0617p0030</name>
        <name evidence="8" type="ORF">CWI37_0775p0030</name>
        <name evidence="10" type="ORF">CWI38_0086p0040</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="PITJ01000775">
        <property type="protein sequence ID" value="TBU01210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000617">
        <property type="protein sequence ID" value="TBU01835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L420"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0617p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0775p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0040"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU01210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU01835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="224" mass="26217" checksum="BFAE671ADEC1C7FA" modified="2019-07-31" version="1">MDNFNKNLIIVDDTDKIIGSKKALVSHHLKTLTLHRAFSVFLFSSDNKMLVQKRSLDKFVFPEHWGNTCCSHPFLSEMSFKDPLSDVKIHAIKRLQYELGIKENEVGFDDLLFKERIVYIARPEKSEGKFIGTDIKSQETEIFPESQNIMKEGLKSEDFGEYEVDYILFVKKNSSDLTIKPNPSEVMEARWVSKQEFDILFKNEKIVPWVRVLCQYIDPFSYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4J9</accession>
    <name>A0A4Q9L4J9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit beta of translation initiation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0482p0010</name>
        <name evidence="6" type="ORF">CWI38_2289p0010</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000482">
        <property type="protein sequence ID" value="TBU02438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002289">
        <property type="protein sequence ID" value="TBU08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4J9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4J9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0482p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2289p0010"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="4">
        <location>
            <begin position="73"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU02438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="207" mass="23635" checksum="28A629CFA0F1B2E0" modified="2019-07-31" version="1">MQNDSTSSENETFQPLGFDLGALKQKRKEQIAKHKPVMAQKKEVLDSDLPDCLQYEVLLKRALDQLRMKEEGQDAAKMKLSLDVKREPSSKTSINIVEISKALHRDQEHVMRFIFNELFTTGSVNKEGRLFLKGVFLKSQVQDILRSYVEHFVVCKSCENVENTNIIKQNQLYFLKCSRCGAMRCVGNIIEGMRSKGKAVHSVRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAT6</accession>
    <name>A0A4Q9LAT6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0180p0040</name>
        <name evidence="3" type="ORF">CWI38_0365p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000180">
        <property type="protein sequence ID" value="TBU04131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000365">
        <property type="protein sequence ID" value="TBU13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0180p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0365p0020"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="64" mass="7327" checksum="24BFC1C2CA62E35A" modified="2019-07-31" version="1">MPLKVFQSAIKKRIRLIMRKDKIYEGILEDYDVHINVYLTDATEISDRSTIINGGSIALIDICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEF8</accession>
    <name>A0A4Q9LEF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0011p0030</name>
        <name evidence="4" type="ORF">CWI38_0021p0200</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0200"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="326" mass="37699" checksum="FFAE96178F390223" modified="2019-07-31" version="1">MKLTECFIRIYNSKLPQIIKISLIGICESIRNIFTFNSRKKIFEIEFANEEINVVITGGNKGIGKEITLLLVKHNYNVHILARDKSSLEEIKYYCDKIQKNKCFYTECDLSNPRSIKSAASTVFKNKKIHLIINNAGILEPSIKYRNNIEINFFINHLGHFILFKELERRICAIRGRVVNVTSCAIYSVDEYFTAKNPFFSFMKLYSESKLCNSLFSLAIKNMSGIRSVAIHPGIIATNLFDRSFYGYFVWLTTKLASRFLVTTQEAANVVINACFTHEIYSENEKCDLFIGYDKGIIPKSLNVDNSRKLWNLSEYLYQKLERNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEL6</accession>
    <name>A0A4Q9LEL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative M48 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0027p0010</name>
        <name evidence="10" type="ORF">CWI38_0235p0020</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000027">
        <property type="protein sequence ID" value="TBU05280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEL6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0027p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0020"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="243"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="413" mass="48033" checksum="EFC170D14CF99B27" modified="2019-07-31" version="1">MKKISKNFIYSVFIITLLTITYEIFSISKFRYSLSKGELGIATNSNTYVYASRNPEEFIISQEAASKSKIFTVTMDFVKHSVLVAIALLFLDSNLQRMMLKLAEKRVTLVKSGFRDLKKPEINFVCLLYSFYLITIFVVGLLTAKSYAIEKILKCFGFFVAFYLLLAPVLVFITYILLSKFHKKFIIACFIAYAIKVLPDILIQDKVDYTKMTKMDINEFPENIQEVLIKYDLQDRVYKEIFPGKEINAALIGYGDGKRMEIYGNYDEFDQEQLYSVFLHEVGHAKENSLLRKTIIYFIVLVLEMLVFLFLYDRVSSKFSNQDISYFTAFLVLAFIYRVLLRQWLFSIYKLGSQISEINSDLFAKQYGYDEYLANTLYDIGIQSSDYLFPTVIYNSLRSGHPSLYSRIEYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEU5</accession>
    <name>A0A4Q9LEU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2558p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002558">
        <property type="protein sequence ID" value="TBU06529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2558p0010"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16972" checksum="EC80086986DB83A2" modified="2019-07-31" version="1" fragment="single">MASKEIHETGERSWIEHLNNVIYAYSITVHSSTNKSKFMLFFGQPVEENAADTQWILEIASDVHEEFIETLTTITTIIADDLGSDSRVLSDINFDKEDFDMNTKTKRAPFDSFYDNSVFTVTAILMNNMIEVKNNDGDTRTVFSGVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEX7</accession>
    <name>A0A4Q9LEX7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2550p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002550">
        <property type="protein sequence ID" value="TBU06559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2550p0010"/>
    <dbReference type="OrthoDB" id="2195638at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10949" checksum="00812D47B03BEF74" modified="2019-07-31" version="1">MSEEKNENLELELIELTNEIKNKTAYYKSIQYPTSNSLFIEIFRKFHIEWKNDKNIICTIKNKKLNDVFTIFHDDNKTEKEINDLLWKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFS7</accession>
    <name>A0A4Q9LFS7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2489p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002489">
        <property type="protein sequence ID" value="TBU06893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2489p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38501" checksum="5E01085532C86BA2" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILNVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNVLVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIGSHSVQEILDNEYAEIRLDIRIKTDVKIRNNRPDIFVLDKKRNMITLIEKLRKYDLLANELGLIYKCSEEIISYVMNWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTEDDVKTENTKNILPLILNGTTTEKEPTINTNEELELKEEVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGK1</accession>
    <name>A0A4Q9LGK1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2648p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002648">
        <property type="protein sequence ID" value="TBU06070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2648p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16238" checksum="56E99ABDE6A99179" modified="2019-07-31" version="1">MMRRKNFFVPLFENEKFENDKMNITFNLPEGVDPNNVEIKHEKNAYHMKYKTETKDEKDGVSFSSSSYGYFSRSFPFEIKNPHAEVKENKLFFSFDRGEDTSGLKSIPIKNGNSKEKIVTNKKETDSNASCSSGKCQHCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGU9</accession>
    <name>A0A4Q9LGU9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2626p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PITK01002626">
        <property type="protein sequence ID" value="TBU06180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGU9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2626p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU06180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="279" mass="32097" checksum="1D563F2C66C72A8E" modified="2019-07-31" version="1" fragment="single">DGIVTKYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENMNKIIIGNKGGISNTVVNNRVLDSTNQRNKISIENKGVLTTNMLNNRVGVLKMCEILRCTYKYMCVINMWKVFIDSKLQGVRECLICYLVMCIEDNCFPTFLCKVCKNSYHRRCVDKMVRKSGNKRCPICRNGRGIVEWERNSRMGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIN0</accession>
    <name>A0A4Q9LIN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2315p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002315">
        <property type="protein sequence ID" value="TBU08033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2315p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="516" mass="59534" checksum="DA2AA256A6BA17BD" modified="2019-07-31" version="1">MSKKIARGILQGDSLSPLLFVLCMDPLSRQLNEKYPKVTVQTDAESHSTNHLLFIDDLKLFAKDGSTLRIFKKIGLEINKEKSDTDDTCCYDTATLLEGVSVYKYLGIIEDCRGIPTRSAFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYYIGVLRLEPADFSKLDDAVLAVLVKNMIHLRPGCKKRLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKITKKSLEEAQLAKLYNEIEKRKLHSKLYKARKNELVSVSDSSRWLKSGNIRTRNEAVFCYIQDRDVFWGTDSMGQHCNKSGKTVDHLASRCEKMLGHDYTRRHNEVEILDNLYAEIGMETRIKVEVKIRNNRPDIFILDKKKNMITLREVKITSQKYGLLTNELGLIYKCSVKIIPYVMTWDCIVTKYHKSHLKRLEIPMNVEAYNLSIVLKKMVETISFDRIRGLEASMGVIKRSRMHEEPITPLKEAKREEDGTTLEEPTNNINEESDLEKETAVVKEVEENIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLI7</accession>
    <name>A0A4Q9LLI7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2203p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002203">
        <property type="protein sequence ID" value="TBU08947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2203p0010"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44731" checksum="C745185E7B669458" modified="2019-07-31" version="1" fragment="single">MENLEGNLLNLERRDSKYKQLTKEQHEGELLKLGAINEVSSAFQNLACCTNSIQKRQDMCHVSSKKKKRCGRKPKEYSKNLAQIRNIPLNRRGTLRSLSLAIDIPKSTLFDIFISGKYMKRISSTVKPTLTDKNKMDRLKFCLSKVNLANNGDFLFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEEEPERNYKSKRFIMKIMFMAAVARPRYDAHRKNYFDGKIGIWPFVYQEPAQRNSKNRAKGTMITKNVESVTAVHCKNMIIDNVIPAIKSKFPPAYKKKTIYVQQDNAKPHFSDNDADIVALGSADDWNIKFKAQPANSPDLNVLDLGFFNSIQSLQHEASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP16</accession>
    <name>A0A4Q9LP16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1993p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001993">
        <property type="protein sequence ID" value="TBU10139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1993p0010"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26345" checksum="9CC740971D5D78B3" modified="2019-07-31" version="1">MKKISSTVKPTLTDKNKMDRLKFCLSKVNITKNGDLLFDDLYDYVHIDEKWFYLTKVKRSYYLMLSEEKPNRAKGTIITKNMESITAVHCKNMMIDNVIPAIKSKFPPAYKKKTIYVQQDNAKPHFSDNDADIVALGSAFDWNSKFKAQPANSPDLNVLNLDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHLSKGKLRREGRLLEKYVRSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP44</accession>
    <name>A0A4Q9LP44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1956p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001956">
        <property type="protein sequence ID" value="TBU10188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1956p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9602" checksum="C0F7F0E57CBCF2CC" modified="2019-07-31" version="1">MLDFLLFYFFSDIDLTMVNSYPSCDINNVGSSCEVFYCVPLDINNKQVQNDEKLSYFEDEQTANKLLRFSRDTESKKHRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPG0</accession>
    <name>A0A4Q9LPG0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1827p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001827">
        <property type="protein sequence ID" value="TBU10353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1827p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="79"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="30260" checksum="4735C0049FACF082" modified="2019-07-31" version="1">MANNSEDTNKVRNRNLKYIAAVLICLLLASTLLLIGVKLFKEKNKNENTKNTSQENILSDEKVCSKMQEEFVTYLQGQKKINILKFRFDTGLSYAGMGLTDEAVTHLAIVNAANPELLPGLGGLNKGITVWVREREGLSKNGSSEVWNNLTACAEGQTESTKKLGLAAYSRFNGGILLHVIGPQGSLVGNPQQCKNLSEVTELLTNAYKNCLRMANDYECSHIIFSVISGDLFCQSNSKVGFKKSEFLCAIQNAVKKFIEKTEFKNIKVYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ43</accession>
    <name>A0A4Q9LQ43_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1847p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001847">
        <property type="protein sequence ID" value="TBU10327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1847p0010"/>
    <dbReference type="OrthoDB" id="2245799at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="27100" checksum="97B937CC02CD541D" modified="2019-07-31" version="1">MLGDYICFKRRDHLIRAVFGFKTVLIKQIIQTEHALAHIRVNKMMALFVEKYYGIPKAYIKEYVKDCEACTRFNCLKTIQPIYINHITKIHALFIMECVDCMRFTKKLHETGEGRRIEHLNNVVYVYNRSVYSFNNSLSESIIVENEASTIVPDIDIDPDIVLIRSDVAKNFKTHRKRIIESKNSNEFNAPFDSFYVDFVFKVIAILMNNMIEVKNNDGVTSKVFRGVIKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ73</accession>
    <name>A0A4Q9LQ73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1664p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001664">
        <property type="protein sequence ID" value="TBU10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1664p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="55883" checksum="D9FE479FAC5965BD" modified="2019-07-31" version="1" fragment="single">MDYKNDQIDIIKSNHEVSSINFINVYVVKIHKSNETEEFRLLKSVLNLKFNSYMILANIHNFPISLKDDNRMILVEDKFFILLSNFIQFSFYFPIKNLSFEEFFVLIEFLDALDANFDNNFLNIIRNILTSLSTSVDNKLDEKAKSFVAETSKHISYKFYCMIINEILDIYFPYQVLYDIFIDKDSYFEEFKKYEINFEKNKSEILTITIDLLDFNFINIFYLEKPKRIDLQKIFESLKKTMESALKKKSIGFKTSIYRNDLEPTECEITEICEHSWLFGFLISEENLHNVMHFRCKNLYWSISGRICNFKKLDKLKIKLITLDINELIFFDKFSHQFAILKLIYSKIYSNVLNDILSLESLEYLAFSDTKIVMNNNASFSTFNYSIKYFEYHGSLFHNFYMIFEFIRMLVNIKTVVLNLTEDFVPLQYEEKFIPIKKIENLIYKNFNAQINHSSAINQFIATNKLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE0</accession>
    <name>A0A4Q9LQE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit 2 of splicing factor 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1620p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001620">
        <property type="protein sequence ID" value="TBU10668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1620p0020"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="20301" checksum="5DB2C19EA10E7AED" modified="2019-07-31" version="1" fragment="single">KRKRIKKIIEETSSIIKDKYHRINSIGKYECLLCYTLHNTEINYISHCQGTKHQNLLKKQIDTEKIIDLKKNKLSPKYIIRNIIQENKKGHNIQLEYTQSTEKPVFKFINSLEQKVEKYNKENIYLVILCEPYINVGFKIENKKVDECSIISYFNEFEKLFTIQFLYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE3</accession>
    <name>A0A4Q9LQE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras GTPase-activating-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1768p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001768">
        <property type="protein sequence ID" value="TBU10427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1768p0010"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="928" mass="108290" checksum="D4E199E1458B28E1" modified="2019-07-31" version="1" fragment="single">MTISPEQKRSIRTNVHERLESGLPLTSAEMDIEREQNHVYEYMCHFEEAKLWLSAVINKNVQNFESELPKGIILAEVGKILEPEIVKKIFLDETLQYRHTDNINFFLQAVLKQGLPKIFLFEVFDLYERRNIPRVIYCIHALAHFLNKKNIFPKISDLIGKIYFSDEQIQEKNEEINTAGLKLPHFKSIAQKLRDELIISSHLIYFFKYFIYKQTITEHQQLKNNTFNILLHHELLLEKKEKIRNFLVQKIKEFLKLHKITILQSKLKSLLYIKAFNEIFYRKKTLTLFSLRFYIFLLFNTSKTHHSYESEMHKIQTKINKILNENFMHEKYIDELEMRISLLVNNKVTVSNMVMNKPIPQDITLISQDTPHYKNLTTIFYILQTNPKYLIKILYNIQDKDTFIINTIVPLFYFGHGIREECLVNKLIDHILDTYNKEGDSCNGEGYSGDKDNYSGDRDNYNKDNGYSNYKDNKDNSNYISNYNTDIYNPYPYTNNNNPYNNNKYTNTPVSLCPSAIICCKILTHFYRVSKESKNHALSISSIISNLSVLEIECDPVNIYKELYNSQPLREIALQDIKVKNIYISRLKTLRGVINSLLNILQRNITNTPFILRYFLKQLFIRKYSFFGIKNMFYEEFILPFIIASDCFDNKYVSKEVRDKCVIISQLMSIIVGMECGLECDNDLGDSFSDNSDNSFSDNNDNCISSKDSSKDNNYISTKDNNTKDNKEINNKDNKEQIKNKEIKNKEIKNKERDNKEKNNINTKDNNTNTKDNKTKEQINNTKANNTNEHNDPFLCDSYGIFVPLIKFIREASIKFNEIIISLGNAEDLNEHYRFGGLSSSVRVQRACVSFTATEVNDILSTYKIYVKGVGGSSSRNIGNGEYIVNGDNSNRDISNRDNISNNHISNKDYISNPNNNPINNHTNNPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ7</accession>
    <name>A0A4Q9LQJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2-like putative regulator of chromatin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1578p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001578">
        <property type="protein sequence ID" value="TBU10738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1578p0020"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="111"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="376"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="546" mass="62899" checksum="C042908CBFFC3E36" modified="2019-07-31" version="1">MPSIPVVNKPVKMKLKEDGFIEVKPSNKIISTILTSFPNKKSTYILETNSWKINIEIYEDFCIKLKQNKILYEEIPKGVINVLKKNIKNEFYDLKNGIYSYLLPFQMQGVNFALNRKGKILLADDMGLGKTIQALAIAYYYKLEWPLLIIAPASLLYNWAESINTFLKMESTIIRKMSDFGEKISIISYDQASKNSDLILKLKHQVIIVDECHYLKSQQSKRTVNLLPIIQNSTRSILLSGTPAMSRPLELFSIISAIDKFIFPKFYEYGKRYCNGRKVGHWYDYKGSSNLEELNYLLNKTFMLRRTKECVLNELPNKFRRHVILNLDDSKTENKDSTSLNKILNENKKNLDENLTEVSDNIMTLYCEAGKLKANKVIEYLSCLIEKQIKFVVFAHHGFMIEQISKFLEETGINFIRIDGKTPVNHRQQLVNKYQNNANITVALLGLTACASGLTLTEGKAVVFSELYWNPGTMLQAEDRIHRIGQKDSVDIHYLIGKNTIDEYVWPKILKKLNVLESLGIGTNDLKDIGPFDLKQKRLENFLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR7</accession>
    <name>A0A4Q9LQR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1677p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001677">
        <property type="protein sequence ID" value="TBU10567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1677p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020886138" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10059" checksum="1D0A5A5E4DD752D3" modified="2019-07-31" version="1">MFYLSLNIFFSFLFSYFFVNISCSDRNGSQIENIGMKKMEKSNSGSDKNKDSGCGFHGCGITCNHVSVIISRSDSDSKVKFSSNASNSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX0</accession>
    <name>A0A4Q9LQX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1459p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001459">
        <property type="protein sequence ID" value="TBU10953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1459p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="194" mass="22417" checksum="C21D01CB49B3F3C5" modified="2019-07-31" version="1" fragment="single">RPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEELKPYLKEEKRGEDGSKKFKPKNKATFISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR50</accession>
    <name>A0A4Q9LR50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1687p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001687">
        <property type="protein sequence ID" value="TBU10546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1687p0010"/>
    <dbReference type="OrthoDB" id="113327at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13223" checksum="0D1634CB834DB91D" modified="2019-07-31" version="1" fragment="single">DDWNIKFKAQPANSPDLNVLYLGFFSSIQSLQHEASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHISKGKLRREGRLLEKYVCSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR63</accession>
    <name>A0A4Q9LR63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1495p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001495">
        <property type="protein sequence ID" value="TBU10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR63"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1495p0020"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="353"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="560" mass="63518" checksum="252A4B433132F148" modified="2019-07-31" version="1">MKKIGKFLIKKNCVTSNARTSTLQLSHGTLNLPKFMPVATYGCMKGVLHSQLHNTIILSNTYHLRNLNRNLHQFTRYNHNILTDSGGFQIVSLNDNIISEEGVTFHEKYKGKVTDKNNTESEKFNEDNEVNKDVRDKGSKEDKNNAESDKYSKDTEESKDINGEDYLKIQQCVKSNISNTNNNTPLYSTLLTPEISIQIQNKLNSDIMMQLDDVRNPLSTYNDIECAMYRSLRWLDRCILEHKNTHQLLFPIIQGGLFKDLRIISTTEIKKRLLFYNEEEFCKMGVNDSTNEQQGISNCTSEQLGLSNNTSEQQGFNNNTDMQQGLNDSSNKQQGVSNNTPTTTINTPKVNMCRGVAIGGLSGGEDKNHFCDVISLCVSILGPNIPKYVMGVGYPEDVLVCICLGIDMMDCVYPTRTARFGIALTDKGCIKVNTVEWNTSDRCISTDTSTISSPISNTSISNPTSIAPTYSPIYPIDPTCKCYCCLNYNIQYLKTLKNTTNLCILLTLHNLFYMENFIDRIRISIENNRLNIFVKEYVKNRYNNQPPEWFVRAMKSVNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA8</accession>
    <name>A0A4Q9LRA8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1761p0020</name>
        <name evidence="2" type="ORF">CWI38_2069p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001761">
        <property type="protein sequence ID" value="TBT98426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002069">
        <property type="protein sequence ID" value="TBU10045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1761p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2069p0020"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="43946" checksum="BB2D82B51432CEF6" modified="2019-07-31" version="1">MDILEEICNSRSNNGFVIKNYKKYYEHCRSKLREIRKMKDSLRRQILMEIYILERNLCKAFLFLEKPRKSRKNIKKCIKNIEKNKFEINDKKILKKYYFSLLDMNMLQYSKGLEKLISLRSLLDPRYTILFDNVDELIEICAVKADLKDKIPNSYVCKWNDIEIKFKNEKEFKSFENNELKIRTESYNYVLISKIMELNLSEQRLLKKMDKKNGKLKNVYEKIKKYFNSISDLKIFLKKNYVNSEYLESLSSDANQLLKIYENLVKCRTPGITFKSEENILPERYKDLKNFVDFSISKADIGFSESIKYLEEMVNGYFEPRSQYENVPFLPVFYDNAYDYIVYPKPENDLALISELKNTENEIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF9</accession>
    <name>A0A4Q9LRF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0146p0010</name>
        <name evidence="3" type="ORF">CWI38_1349p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000146">
        <property type="protein sequence ID" value="TBU04358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001349">
        <property type="protein sequence ID" value="TBU11163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0146p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1349p0020"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="184" mass="21104" checksum="02ED345DCE96B50C" modified="2019-07-31" version="1">MTLVEVGITSTDSLKIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVETYIQSIVLKKTVETISLDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKTLKPKNNTPLISQGGTTLEEPINNTNEESDLEEETVVVKEIDENIYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ2</accession>
    <name>A0A4Q9LRQ2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1334p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001334">
        <property type="protein sequence ID" value="TBU11189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1334p0030"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9937" checksum="E1E67C2D38846D33" modified="2019-07-31" version="1" fragment="single">DDELTYTKVQQDCKDFGEIEKIQFGENSVKINFLFITDCYRAYTELKNKDFYDNYNLSFGNDRCGNTSALDVVLYLQENEFFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR4</accession>
    <name>A0A4Q9LRR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1467p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001467">
        <property type="protein sequence ID" value="TBU10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1467p0050"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21622" checksum="62D0F88EA5583FAC" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPTNVEAYIQSIVFKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHKEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKENTAGKCNIKENSVISENRRNTPPVSRQSLFIDLKSVRKQPKMREINVLEYNEEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS2</accession>
    <name>A0A4Q9LRS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1945p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001945">
        <property type="protein sequence ID" value="TBU10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1945p0010"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="19978" checksum="85D4648DFA6AC777" modified="2019-07-31" version="1" fragment="single">MKNIDLRNNTKFKILIRKMGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS09</accession>
    <name>A0A4Q9LS09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1739p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001739">
        <property type="protein sequence ID" value="TBU10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1739p0030"/>
    <dbReference type="OrthoDB" id="2233964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="460"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="572" mass="66018" checksum="F663D8781363F6AF" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVNKSDSELQKCKLHPPAISLPSSSYTTITPPPPAKHAVKCKIPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADQKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFSCTLDTDAKIRQEENGERRRITTCLADTCTLTDTTEYIILRDKFLSKIKEISENEIGKVVVRTRKHLNELVDSKVLDLINRVVINSEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSNVTDLSEALVKKNESLNVYEKKIAMHESRKQFRKENRMFKLFRGLFYRGLSERLESEHAVSRDEIVSFWSTMWNKNDDAVTYDDYLIPFISDNHPTMFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYLYDIVKVICLEGTPQADWFYCGLTYLIPKGIPQRGSDYRPITCMSNLYKLTTRCVTKVVQIEVERRGLLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDVKKAYDLIEHADLTQCIENLNLPDWIMKFIKVIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS17</accession>
    <name>A0A4Q9LS17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1409p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001409">
        <property type="protein sequence ID" value="TBU11057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS17"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1409p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="25345" checksum="965A01B0A6587E56" modified="2019-07-31" version="1" fragment="single">MNVEWKNLNIELINKNKSIDKKYIKLVQNAYGEAKVGELCAIMGPSGSGKTTLLKALAGRIPDGSRTSGVITCNKSERKQSDWINNVAFVDQDDCCFDDLTIRQTITYSAKFRLKNTNIKVKDKVDAILTSLDLTKVADNRTKSISGGERKRTMIGVELVTDPKIILLDEPTSGLDSSYALDIIKLFKKIAEKNNVTIIFTIHQPSYEMFLLFDRLILLFNGNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS21</accession>
    <name>A0A4Q9LS21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1306p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001306">
        <property type="protein sequence ID" value="TBU11244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1306p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="36085" checksum="0B6A16B90BF2E2D8" modified="2019-07-31" version="1">MVEKVTMKKKRTHHSKLYNARKNEFVCVSDSSRWLKKGNIRPRNEAVFCYIQDRNVFWGAYAVFPHCNKSGKTLDHLATRCEKMLGHDYTRRHNEVVRCLHLILLNRYKFNYSKQIRSHSVQEILDNKYAVIRVDIRIKTDFKIRNNRPDIFILDKKKNKITDIEIGITSQDSLQIVETEKLRKYNLLANDLGLIYKFGVEIIPYEMAWDGIVTKYHKSHLKSLEIPMNVEAYIQSLVLRNTAETVSFNRRRRHESGSNSEESWERASMGVSMRAEMHEEPIPPLKEAKREEDEETEVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF2</accession>
    <name>A0A4Q9LSF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1689p0010</name>
        <name evidence="6" type="ORF">CWI38_1181p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001689">
        <property type="protein sequence ID" value="TBT98581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001181">
        <property type="protein sequence ID" value="TBU11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1689p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1181p0010"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="148"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT98581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="233" mass="27648" checksum="5DD81A1EF7C4D062" modified="2019-07-31" version="1">MAIKNSSSDENLNKTEYLEESREKSKEEIKEESKEESKDKTEKQEIKEVIKEECKEEIKEECKEQNEKQMQENEIQPRQEEIKREELQSIEGIQLPKEEIQREELKVQPQPQEEEIQGNENSSELEILKLQKMQENKTEKIFDYKNENSVVVKNFDSLIKKEDLIKYFSSCGEIKNISISKNYKNRSKGMAYIEFSKKENVRIALSLHNSVFKGKRISVLAKKILNKRNLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT23</accession>
    <name>A0A4Q9LT23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1055p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001055">
        <property type="protein sequence ID" value="TBU11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1055p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="88885" checksum="9273D4D0609523E2" modified="2019-07-31" version="1">MNIGKFFSMLAIWCIGIVGIVALLGVPLKRKSSLVSHDSDIGSIESNLTDIKSLLVRLDSLEQEIASLKAIMNGEGNRNMRHEIGTKIDLDTKFTDDEKKAEEIHKRLDDEKKEEEIRRDEEHWRNEHNKSNNNSDNGVNSKANLINTEILENNEEGKSKLPPNEKGEMNEYDPKQFEFYKNYYRNFGYDFLGPGKLVPLINENSTNSISFTAHSTQNDTNIHDDSNLAFLENKKEQRQDDKNADKREENLVLLSSKKDKKNNGSNEHEVETENISMTNDKDKPSGEFLSARRDFHGHEALNDSDLAHMQEIDNHEPSLANPGISDGISGITVKNPVSSLKLHVFKPNENEKALHKLSIMQDFPFNIGEMFSSAMKNMINHRKEVENGMNNNEKPKIPVTQPNKPFLPDKIKNVLKTKDLDEKNENLSLQMIPTKSEFDKKDEPMLNQQSFESPPSLSKTEEFPSLKKENKDGLAESKIVLKDDLNFKIAEVSPNSLESLQPGIKSEALSNTQSPDQTLKVKSTNESSSVEVPNEKNTVQDLELGNQVAKSFDHVNNFSIIQSKNSTNGEKGALIILKESDHKSSKPNLPKADTITENEHKSSIETKVLPTLPKNEIPQIEKTTTNIDLQKEFQINELPEPVSLLSSDKKEEEKPPKPQVNTNDNTPSLPKEFIQKANEAEQKIFTTSSTGISNKTNSDIKTTSFSPPNHLEILKNVLSDISRPNVSEIQPLADSSDSSDNQDDFIPPKIIPVIKPHSNPKKNSLHQLNHKKSKEGTKSEKKSKFSSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT99</accession>
    <name>A0A4Q9LT99_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1536p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001536">
        <property type="protein sequence ID" value="TBU10815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1536p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="89037" checksum="5A4E635A8BD72C8D" modified="2019-07-31" version="1" fragment="single">WFEKNKNSEILFYHEIETNTAVNNEFECDYYLKVSIKSNKPQKNELNRVYTYKKENFIKYEVFDKILVANTMEDNNGKIECNFDIIYDLKLTEDISSLPEKIDFNLVITLFLTFKYLKVVRQENVLKFLEILILRMYAQQYGIDSNNKYLVLENLFKPDIFKNLEFFNKKNLISALLNNFMIYHVFYEDNLILLNNSKDDYETDFFNEHIPYKNLLINDYRVFYKLERVFKNVSISNYFHILLNEIDIKSLIINNFEESEKHKADFRIFKRSTVSFKSIIISNLLYSSERILYELNKAIDLKLEYFGLCNLSVENNYFLIFLKSQKLKGIILNNVVLKIDIHFFDVYMNKNKTLKYIELKNVETMFTWIEFIDRLNIEKIILSFNSESVEENFIRGFDSLENTLGVQYLEIRFFNYRIYKELCKILRNFPALQTLKLSNYQPDKKINQKFHKVIENMKQLSTLIIEHEYFSNKFLNSVFQNKRIQVLHINNYIYKEKIFKLEVLSNPNHLTHLGLRSINISASSLVQIFRLKNLESLSLKFCDLEAIKNFKTHHVMATNIRCLNLKGSILNSFRDFDILEKLNYLEKLTLSGLQLHLCSLNKLNSNCNLTLKKLSYIWGILSADDLNRIKYLEVLIQLNISRCEFLNTSLCELGRNCNFLSSLKYLDLSYVELTLNDFLYLQSFKHLRNLKISFFRSHGHKFDFSMNSYSNNYFFSRNIYRERTKFKLIEYFGEINSSENYIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTB1</accession>
    <name>A0A4Q9LTB1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1235p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="PITK01001235">
        <property type="protein sequence ID" value="TBU11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTB1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1235p0020"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="229"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="462" mass="52758" checksum="45CED9787D9B7134" modified="2019-07-31" version="1">MSENQTNQKFTDLPLSKETLAFLNENGFDEMTEIQSKSILPILSGVDVLASAKTGSGKTLSFLIPIVEHLKMLDFKDKHGTGALIIAPTRELAIQIFNVCSKLIKYHNLSVTIVIGGINKKIEDENLRKGCNIVIGTPGRLMDHLKNTEKFKISNLKILVLDETDRILDVGFEDELKNILKLLPENRQTLMFSATQTSKLEDISRLSLKNKPLRISANSSNHDDLICDNLNQFYILSTESKRLAVLYSILKRFKSEKVMVFFSTCNSVNFHSQLFHFIGFKIISLHGKMNQIKRSNSFKNFEKEKTSILFCTDVAARGLDFSNVSTVIQYDVPVDVKEYIHRVGRTARAGKNGNAILFLIPTEEKYIKFLKTKNMILNEYCIERIKKITEKILKIVENNYFFKKNAILAFKSYLSSYSSLSLKEYFDVRKIDIEEFCKSFGLSSMPAIQFSANFNKKTQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD1</accession>
    <name>A0A4Q9LTD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1539p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001539">
        <property type="protein sequence ID" value="TBU10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1539p0020"/>
    <dbReference type="OrthoDB" id="2193149at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10160" checksum="27CA0B8D679D68A0" modified="2019-07-31" version="1" fragment="single">MKSFDIKAAIEIYSKEKRDVKTYFVKRKKEKELHTIEVDVERSFGFLKGEDKVSLARKEIFKEILFKVLKTIPVEYLQSMSEIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN3</accession>
    <name>A0A4Q9LTN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RSE1/DDB1/CPSF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1379p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001379">
        <property type="protein sequence ID" value="TBU11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1379p0010"/>
    <dbReference type="OrthoDB" id="2201422at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1275" mass="146962" checksum="77516A10D6B5539A" modified="2019-07-31" version="1">MKYGIKTIKPSNSVICATRTTFKNIECVAVSKGKRIDLYNYELKQIGTIYTHTIITHMTSLKIKEDFILLCFSNRNNFSLFVNGNFLMTRFLISSWRDLGFTNDHSEGNELNEIDESTYEYSIGFSIPVKVRSSSSIIVVVLKNNQVLVAYPSVKSISFDTPVISQLSLQIIDFVLLSSKILFLTKDHENKFFLQEYSTVNLNVQLESSKDLGKEFLGIIPVFTQIESQKNPEKNLKRNKSTPKIEDEQKNVIHSNKREKKRKNQLKLSEINKKSSFVSKNSKKISYFIGFTNQKILVYYKDKIYAETDFANPRMICYIDLKSGILMSMQENELIHINVNEITNIISDQKEVDFEFDIKVIAKLPSRVENIVELTDEKILAFSNFGDSYLIDTSKSMYMKVILNFSNFHNLINNDNNLYFVSGKYCQNLLCKLSFDISFSDEATNKDRNVETFKEPLKTIENKNLDSQDESDISLTKNILPEDDNIASSKILKKVQFSQPLKKAWLVFKKYYILSFINSGKLMDRDSNKILQNFDEIINLHDNTNLNILKIDKTNQSDKNTSKKIYFNTKSSVYKFYENLQSKYIDLKFITISYFLEEKCFLFTENKYLIVLNLPKLEILTKNVFNYEISFLIALKVSKKIEEPKRNVNVINIQKMDPDSECSIPSVFQKSSEENTKKSFRILISTFTNDFLILDSKLNVKKIFELKCIISGAFYKNVLLLSDISGKIYSLHMDRPDQVIILEDENTCREQEAYYNTNSDMFTDESLANLNINVVPNLICKKMYPTNEIVNLKNGFLITTGKEPLFINLTNISTVKVYGINISGYFYASQVFIEENDSKNKIYLLICNGETLYECIFDPKPSYKITKYEIDNDVRLILVFKDTSRMIGGFTKYDSEEDSILENEYYGSSENININTPEYKNKIPKSINTNRETIISNKNEKNEMLKDIKSDSHLLISKLVLYDNNRVKDSLVFSNEILMRGVANDKNKIVVTLNVNSSEPTGKLVYIEIKDKMKILFEISKPGLVFGLDLSGNVVVASFGTAIHVFKIVGKALVDVCSVKHQITPWVIKINGCSIAVGDLTRTVSLYDMNIEKSSITEELRFPRRIIAEQMVFIDHRLMIGDGMGTFLIMEGLDEHLIAEAWFLYEESITSMQNNTFDKSNRFINSRFGEKEASSNVVYFSTELGSIGVISRMDNKITEREYNSLLHLQSIINSGFCIDTDFILTICPKKTRSLNFIDFDILNLYWKLDRDRICTVMSVKQSELESLLEMTCDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB1</accession>
    <name>A0A4Q9LUB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative vacuolar protein-sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1351p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001351">
        <property type="protein sequence ID" value="TBU11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LUB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1351p0040"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1335" mass="150395" checksum="F7EDFE418647F76F" modified="2019-07-31" version="1" fragment="single">MFKSIATALLNRVLGNYIENLNRKQLKIGIWNGKVEMSNIILKLPPTLSSTYFTLIKGTIQSLSLTIPWSNISKNFSFLEITNIQITLLTGITDPYKIKKYIIEALTEKIIKSISEGISEGSRYDNNNRGTSSRDTNNNNRIDTNNNNRIDTNNTFITRIVAKILNNLQIIIKEIEIRVITLEGHIFKFKIDLIKMKSCNSKWDMIEGVSDRDMMEGIRGVSDRGSGVEGVSDSTNEQHPVSDSINEQHPVGDSTNEQHPVSDSTSQHLVNNDTNTQHPVNNSTSQHPVNNSTSQHPVNNSTNEHHPVNNSINEQHPVNNSTSQHPVNNSTSQHPVNNNTTHHPINNNTTHHPVNNDTTHHPVNNNTTHHPINNNTFKIIHVKGFSININNYLLFDLQIITIKCTINNKNLLFKTDIEIPNINTELTIDSYKKVIEFIHTILVEKNKNENLMIKSINSKILEIEEFIRKGGVMDKGMLEGVNDNSSPIEGVNYKDSVIGGVNNSTNEQHPLYISTDVQHPLYISTNEQHPVNNQTNTLHPVNTSTPNINTHIWNLIYQIYFEKYKINTFDRNDTLNILKENEKYCDLYRKKINKKIKKEEEIELNEFENKNLIKKIINLRNEVLNEKTPKKSFFSYFWNKKVSKEDKKEIYKAIEYTDSKGSIVGEVDSKDSDRNTLGSIDSVNALSSIDTNTNNNNLTLPTSPYLDSDSLEYVDALEPSDETYKKLTREVDNKEVGSREIGSKEIGRREVDNKEIGSREKDSKQSISKKYVCNFLVKNFNFNFKVNENIKYSISIENIESFISKEGRSIDLSLSVYNFNIFYKKYDKTYKILRNKRGVEDSTSKEGGVSDRGSKEEGVSDRGSKEKGVSNRGSKEEGVSECSSKEGGVSDSTNEQRGVSNSTSKQQGVSNTTINYNPLNNNTTNFCNVIYIKEKNTLNIFINEMKILNLKKIFFLFDKLKNNKINEIIRLLSIKDILEGDSGGGVNNSVDRGVSDKDNKQQGVNKSSMYFGGVNDKGSKQQGVNKSSKEEGVNDKDSKQHGVNDKDSKEEGVNNRDNKEEGVNDKDSKQQGVNDKDSKQQGVNDKDSKEEGVNASTNNYHPLNNNTNNYHPLNNNSTNYHPLNTNTYNQHPFNNNLTIVLNIRKPKISISKYVLREMGFILINQSINIKCKEIILTSVICMKNKFNLQVKDLEIFIFKNRIKEYIVNKIPIEITGSIVDTVIGCYDIGKGEGSGVEGVNDKGSVLEGVKDTGSMEGGVSDRGSKQQGVKDTGSMEGGVSDRGSKQQGVSDSSVLEGVNDSTSKQEGFNYTTDVQDPVNNTTNQQHPFNNLPNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE1</accession>
    <name>A0A4Q9LUE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1315p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001315">
        <property type="protein sequence ID" value="TBU11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1315p0020"/>
    <dbReference type="OrthoDB" id="2190704at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="28354" checksum="034F824310850F82" modified="2019-07-31" version="1">MVRTRKLTNELLIENKKIDRGILQGDSLSPLLFVLYMDPLSRKLNEKYTKVTVQTDAGSHSTNHLLFIDDLKLLAKDRSTLSAMIDEAKKFLKVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGILTRSSFEEVQSKLIARVERLCHGRLNAKNLFSAINQHAISSINYHIGVLRLEPTDFSKLDDVVRAVLVKNKIHLRPGCKERLSLLRTELGRGLHSVELRSEHMLLQLLDFLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE3</accession>
    <name>A0A4Q9LUE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1238p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001238">
        <property type="protein sequence ID" value="TBU11381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1238p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16952" checksum="DD951872866CE6AD" modified="2019-07-31" version="1">MSLQADLYLRIGNALAFLSLHNYHTSQDINLTFSKIRNNISQESYIITLQAILRHIFSKCIHFSAFYPELFTNVGNFIENISTLTEQWDFLDSRIKILSFKLCLKYAYVLRYLLYSDYQYEKIVLDSSMTQLYNDISSSFNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG6</accession>
    <name>A0A4Q9LUG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1005p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001005">
        <property type="protein sequence ID" value="TBU11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1005p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="423" mass="50910" checksum="34E57350ABF2254B" modified="2019-07-31" version="1">MFTLEKEVILLKKIYRFFLLENGCFEENPNLFLTNNEQPTLTTLYLLYIDIFEGFNVWINTELKKLFSLSGPQKNLKTVEENIIAFENAHFFSFKDYSQSFFGTERYIFYSYDFIGYWRKSILSILEQKNPYIYLILTEFISFEIQLKEQIDYIRLKKGTYFLAIFKLKLLINDPIISKMQETYKNNCKKDLASNSYPKKSLKVFLKQKRKLRKKFMEILEIFSISFEHNVMYSMLFTLERIMYRFYLTREYYRGFFACYRMLNIISDVLFLIDKKDVNNIIMTIHRCFENTSILNLIANPISKFNYIIDNLDVSLKKKIMVLYIRILKYILDKKTDSLTKNQLGEKQFIILIIKNIEECSKNNKIEVKLRNRKKGMEMCFNGNNLLLLESCLIQRIFQIIFRMKCYTNSKNWVEDLFHGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH3</accession>
    <name>A0A4Q9LUH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin-III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0812p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000812">
        <property type="protein sequence ID" value="TBU12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0812p0010"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF3">
        <property type="entry name" value="LD03007P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27285" checksum="A254F8FBD9665200" modified="2019-07-31" version="1">MLQQKPLLRGRIHQLAFYITIILTIFYITISLIKSYKYELTLYIIGQLTLFGISSKYHLTDWKNEKTKKIFQKLDHISIFLLISCTQSSFVLTLLPKIEIVNKILILTWTITLLGILKIICISNEYEIIDVSLYMIHGVSIVPFFHILLKYINISKMFYLVFGGVFYIMGGVVFGMHRPDPFPSVFGYHEVFHVLTVIANTCFMIPLLQWYYGVINGVSLGVDNCSNSSMGVSNMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI1</accession>
    <name>A0A4Q9LUI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1215p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001215">
        <property type="protein sequence ID" value="TBU11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1215p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020236723" evidence="2">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="29812" checksum="7C9F4AE2E0080F9F" modified="2019-07-31" version="1">MILILMYLLMKVCLCALNYPFEKQIDKLNNEKERLESMTGELNKEIKETYKICLIDSLWTMAYKLGNFYQKIFLPRCVSKKNKKFHDKITVLLKTYKKNNDHILHKKYTAEQIKWVKEVLIEYYSALKTFLKINLRKPYYIMIRKYYNDFNESIKENCRSNTNLHSSNIRSVEDIIKTINKLKKHHFSSIGNACDLIESILSGTIDFDKIPKLDEVILISDEIKKQYLEYTTVHRKKWVAFIEKNCALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ4</accession>
    <name>A0A4Q9LUZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0860p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000860">
        <property type="protein sequence ID" value="TBU12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0860p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="28260" checksum="4365DA07318683EC" modified="2019-07-31" version="1" fragment="single">MYFHKFLSKNNYILISGDEKNQKTPEKVSKLSKNCLKKCSTSNTQAGSSSSNPKCKKIDFKKTETKIQSLPMRTPGNLSCSYQCEDERNLDLSTPKSNTIHASDKIHTDIDLARCLKTSNVVELDLVLKNIREYRLNEIYQDISIIFKYNVLFCDAYNTMAVNTFFAILDKLLEMEKSIMNANHFKTIEYKQLFKEKIKGIDISTSRSAILSKVPVHNMLKKHVDIKKNIKGFTSKLFVSIFFALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV07</accession>
    <name>A0A4Q9LV07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0731p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000731">
        <property type="protein sequence ID" value="TBU12499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0731p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="31437" checksum="4EAEEC5D138688A7" modified="2019-07-31" version="1">MNTVSNIYEKRIIDVDLQTGFVVHTFFDFSILEKIEIVPGLSLKFIKYYLILLQKEEFISSGNINQMVFKDVIENLAIEVDNFEKELTKPSDNTLYINMREVFKTSNEFVDSKVLDLINRVVGEYTKAYVPQSITDAAYIMQAAQVCYDEATHKEKPGSASKENIENKISKVLLSKNLLEKAFFECLQKEDKRIICLSFSEVDSIVRFSSEPNPEDFCDSVIEKAVRHTLPIPRLKADGVITIKEPTIKIKEEADIEEENIMAQMVESYNYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV16</accession>
    <name>A0A4Q9LV16_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0761p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000761">
        <property type="protein sequence ID" value="TBU12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0761p0010"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="16636" checksum="4B2BE487DB966B90" modified="2019-07-31" version="1">MIIIILLILITNIIYTRFYTDDFKKDITVEEFNNYIKTNKIVIVGSKTCPDFKRLKKVLSYINLQFKEIDLNSNLNMRQHISLTYNNKEFPVVFVCGEYIGDYHDFYKRYHLDTFFTDMLYKTLALRPVNFSRFNIVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB0</accession>
    <name>A0A4Q9LVB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1132p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001132">
        <property type="protein sequence ID" value="TBU11575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1132p0040"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="372" mass="43346" checksum="B6E0BF0377F30C3E" modified="2019-07-31" version="1">MKIKQKELEKSLLKANKVFRRSIDQRIYGREHETRKIKEFIETGSGILNICGNPGSGKTFCVLKVLKNTNFLYVNCLVEENIIEEINKYKGLMVVIDEFDKFYMNKKGVCVGLLNKLKERMCKVITISNYLLFCDCSVVFKPYSYEDFVFILSKKIEDEIGEEIVEKGVVEVISRKHSHHGDIRKAFEFILKLINKKSKEVECHVINKKGRTCKSKKFNLIHKNKISSKINKKNTVNVDNKINTVNVENKKNNEIYIESEITTNNKINTESEITKNNKYNIENKINKENNIQDKYLNGESSLISICDVMESENKNEEIESNIHKEIIKELIENNYGCSKIEIYKKYLIKCNSLNIIFVDRNDFGLIYELLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF4</accession>
    <name>A0A4Q9LVF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0790p0010</name>
        <name evidence="2" type="ORF">CWI38_1294p0010</name>
        <name evidence="1" type="ORF">CWI38_1370p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001370">
        <property type="protein sequence ID" value="TBU11125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001294">
        <property type="protein sequence ID" value="TBU11263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000790">
        <property type="protein sequence ID" value="TBU12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0790p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1294p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1370p0010"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="13871" checksum="144A3DD1290CDB54" modified="2019-07-31" version="1">MEKKRQKGIVKFFSYKRGYGFLIPEDQSIDEDVVVYLIPNEVLEYDLIKGPRGYLAKNVTCVGNAILTEGISSTKGTVPNLDIYYHYYHSLKKMMYKVIEKEIKKPELNENNTKEQENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ6</accession>
    <name>A0A4Q9LVQ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0628p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000628">
        <property type="protein sequence ID" value="TBU12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0628p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47303" checksum="112EC1DD35587926" modified="2019-07-31" version="1" fragment="single">DCSLIDYEVGVNESNNEQTALTGDNYSTIVEEGVNNTELPLTGDNSLELQQGVNEQLDIEEEPLTGDNCNIEGGVNQQTETTDTLDLLSNTMHNNTPLNNSNDSPRENTPLNNSKDSLCNNTPLNNHKDSPRNNTPLTNAKDSPRNNTPLNNGKDSLVDNTPLNNTKDSIHDNTPLTNNTINSTNNTPLTNSTNITPLFTTLDTDTLISRLLLTLNDTGGMRYNNGCYRSGRKLSIKKVVEYIASGYKRDRIFMRRNKKGGGICKICIFIDNSKSMKDYKEVVFNLLNILINIINNIGCNIEMYRFGNEVISITGKSDMTFTDTVSDICIGDMGDIIDDSVVLVITDGIFRCDEIYENVLCLLIDRVGLRDMDRVSVVGDEVKVVKFLDEFKMKYCVVGEDNFVEGFVEGVREIVRVMRERWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR9</accession>
    <name>A0A4Q9LVR9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_0785p0020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000785">
        <property type="protein sequence ID" value="TBU12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0785p0020"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="845"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="981" mass="116961" checksum="9826E1D1948C6F00" modified="2019-07-31" version="1">MIWFEASSPYLEKLCSFCENPFPTDKCSYCSVSLHRNCIIEHLKVNNECLIVRTCKYCNVDKRCDLELQKNIANSFFNLTNKFENSDFKNKNEILLENTNFDRKKEFPIEIKKLEIYDAAKQIFTNPLKFYSVISNLQNYKETIIEANKEKNERSEFLSSAKISNILQNFSNSIETAICKKCERFFHSYENKIKKEKNIFDICLDCRYCISCNVFSYENVLLFFLGKYIVFCQNCEIIFKKNEMCNICFKEFKTDDFDIEMMQCDFCHRWIHLDCDARISYDNYLLLSKNSYLCVECTEGLGFDYNKIFIGNISNYDSDSEYDVDCNENIESEDINFKTNEMEKTLILNDQVEENKINSENSIESCNYKDKNCDSIDFYFNIPNLNIFENNLENKKIDFPKALDFENQLFSFNEDFTEKDKSSILRKYLIYYKNDDLKCLICCRDLRRFSVHQSTRLICIKNSFPNLYVHICCVFYYWLEFRRIKISVTNKKISGIENRCINYKDIFEKTMDLNCEKNSDCELNNNRIKRKYKKKNTQLLEEAFKKDLESENKHTNNLKIKRKRKIKSVESENIFPLEIIYKSIKSFSCVLCKENGANIKCIDCKDGYYHFDCSLNILFIGQSTVPRCRNHFFVQYFEFGKIVCFKNRKEKNETQKDKNIELGSANATEKNEISEQEIGKIKTKRGRKKKKCLIEERNESNKEKHLNMCLRYKNVIYMNDLWCKIFFLQNTKNFLFFDGFSFWINENKVFFPEISYLQTNSEEITIEDLFLLNEDGYKTFLNVKKKRNVGKRSKHECLDFEHQIIKENYLNSNFSKLIYFFSKYFLLKKFNMTLTYFLNFVELEKGYCLKKSQIQGYGLFANRVFLPDEPVIKYIGEMIDVTESNFRESFYGKDRCYMFKYDDDMIIDATMLGGLAKYINHSCDPNCYSTKVVCGDNIYIFICSKRIITVDEELSYDYFFEIDEFNVECQCGSKKCKKYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVU6</accession>
    <name>A0A4Q9LVU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0732p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000732">
        <property type="protein sequence ID" value="TBU12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0732p0010"/>
    <dbReference type="OrthoDB" id="2196169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="12377" checksum="CC6C54A0F75C303F" modified="2019-07-31" version="1" fragment="single">NKENFKKEVKLNKKINKEGKTDYKVIKEINDLNDKKLGIEISFYPKIYDSIHTSLNNSEFYFSKNISTQIYKLLSTNKMKLEDLKKYICKENCKENCKENDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW2</accession>
    <name>A0A4Q9LVW2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0642p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000642">
        <property type="protein sequence ID" value="TBU12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0642p0020"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="383" mass="44968" checksum="7BD15DC8C566EA48" modified="2019-07-31" version="1">MQFRMRNGENINENDTNRKPTYLLFPNGSNKKIFRQQGIVSSNPFFDRRILHNRFNESFINKRMIPNQCYDFFPGRIVNKETIRNLNERTKPTTVNSLDLRNEVDLLLNFSRSISVEKRIKVRSNSTLNVDSYDARNEFFDSDDFTRFTNSKNLNTFHISDVDQSVCDPNLKDDIAYKRFDLPNDGLSDIKSKLLNENKEVDNFNEYPDQNKNTSTRVFRRKSSIISPDMIVSRKNSELKAIQIPHRENNIIKNTKPEEAISAIPKPKKSKLIEMFNWIQKYDPIYKANSMAKKYLAFLIKNIDVYTNRRKRSKQENLSSEDKKNNHVESEHHRRDAINLGLYALSEIIPGPVSKSKKSVILNAIHYIMKSRYENSYFSKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW41</accession>
    <name>A0A4Q9LW41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0577p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000577">
        <property type="protein sequence ID" value="TBU12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0577p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="548" mass="65286" checksum="F7198DF1E6DFB9C7" modified="2019-07-31" version="1">MFYFPSLSTHIFFHLLYSYIFGAVVYQEGLYPLYMTGNNTTGEEAHQIIDGYLDPMAECYTYQATNNINPLYQSHQYQYQYQYPIPNTAPFLFSFQPYQNGIHPTSVYFLVPSSHCMVYGIPADQQNLPPKLFFPDNYTESPIRANNNFDTVLSYNSNKITIPLLSFDERKKLFKAVLNLDTTKIHSFLPEIRNFLSNDYFFHDFFENNPKIDQVKFIKKNYSTFLKNISWIENVLNIGNFNYSKTNWNIFELVFPNINLFLQGAEILSNFTSLIYLKNFIYYNLISVNQSKRNCITMFIGMKCIESILKLTNDELARLFPRHLKITNAKEYFHAKRTKIKKNSDLIFNIIEQIFSLGLNLNQDFLFVLCIMKIGHNERYKRSFVTRSKSNYYTLDIITDLIFYFNYIDISEIANNCNKDLKNIPNHTKQPTDKKKLIYNVENTFYSQQLLMNSIKYYHMIFQDIQLKFLNTNIENEIIIPNYFILKKKYEYLNLLALNGIDIRRDLHELCYETFYFFHFVMNYCHNHKSCSKDYLEKLKKSFKNYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW59</accession>
    <name>A0A4Q9LW59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin/thiamine adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0728p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000728">
        <property type="protein sequence ID" value="TBU12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW59"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0728p0010"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004281">
        <property type="entry name" value="PRK05690.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="279" mass="31245" checksum="2C2D05056AEF5746" modified="2019-07-31" version="1" fragment="single">MLYTSELTNSEIQRYSRQIILPEISVDGQIKIRNSKVLVVGLGGLGSPVVSYLATAGVGTLGLLDYDVVEFSNLQRQTIHSERTVSKDKTKSAFLHLKRLNSRITIREHSCMIGDDNANKIIAQYDIILDCCDNITSRYSINDNCKLLGKKYICASVLKWEGQIFVFADDGPCYRCLFPDPKNDNMLGCAEAGVLGPMCGVIGSLQAVEALKLILDSCKSFLLTYNGYENIFKKVEINQKSERCLVCTEKKIPPSNFGTCKNQIMRVSIDDKYKIKWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW85</accession>
    <name>A0A4Q9LW85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0962p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000962">
        <property type="protein sequence ID" value="TBU11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0962p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="9368" checksum="339FAA0A105C811B" modified="2019-07-31" version="1" fragment="single">MHRRKRNLSEVYEKQMFTYEIQENNTPLKYKTSNIITNTIKFSIIYIIFMSYYILLIYLVCSLFEFKRFFTFIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB9</accession>
    <name>A0A4Q9LWB9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0886p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000886">
        <property type="protein sequence ID" value="TBU12131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0886p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="20680" checksum="0C50318DF18A5E59" modified="2019-07-31" version="1">MERYLLSLKRRVSDNRDLDSFDSLFLDSLFLDSLYSLVLDSLDIDLDLNEDIDVDSYNDGLDKISDLTSFIEWMCVCGYKGVISRVVEGVIIRVVEGVSNRRIEGVSKMKNRGVLVIRRIEGVSKVLVIRRIEGVSKVLVIRRIEGVSKVLVIRRIEGVSNNRRVESVNNVYYRVLVRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA7</accession>
    <name>A0A4Q9LXA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0800p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000800">
        <property type="protein sequence ID" value="TBU12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0800p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="485" mass="54857" checksum="70958667A43CF206" modified="2019-07-31" version="1" fragment="single">SNSNYNHVNKLSNEQQGVNKSNSNYNPVNKLSNEQQGVNNSNSNYNHVNKLSNEQQGVNNSNSNYNHVNKLSNKQQGVNNSNSNYNPVIDSTDNLHPHNYTSYKQHPFNNTTDNTTFNGIIFDVRDIRKTGCWMHKKILCNSDSVWVLGIRNNTDIIIKLSINKGGVNNNEYDYEGVSNRESITKNKGGVNNNEYDYEGVSNKESITKNKGGVSNRSSEEGVSDKEYDYRGLSNNSIGNTYDVLGEIEGKITDYCLTRDYIVVLMGVNINIYCLKSCILKNVLNTEIGVLFRNIFNLEEYVIIGGDKGYWVYSNLKGVIHMEKEVFYENKGLKGVKCVNGNKEWGVICMDGENGVRVVEMMDGFVLKGVSDIRDKKVKCCCLKGDKCYIGHGCYISVISRSIEYVGGCYIIEVKGVSDKRGVSDKKDNKKGVNYIDNCVKYRVCDKRVLIIETFNKRVLLIRVDNKSVLMNRLDNKRVLVIEFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB8</accession>
    <name>A0A4Q9LXB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0731p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000731">
        <property type="protein sequence ID" value="TBU12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0731p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28385" checksum="788EBAF177CB8670" modified="2019-07-31" version="1">MIVLCFIRSIFFTEIHKSSVQDKCQNINESDDREYRKDDIEKSQEKNSEKRNLDQGYKIRETYVEENKPNQVLRLKDIINIPTDEGNIGKNDLTMNTYNNCEAIPARNTYLFQNNYENSAAYYNQQIYQGQQACSFNMYETSLNRFSHSTSTVYPWFTNYAPSQSSSDISYAYGLKAFVPCIQTDRLLLETELVNYVFTSLNSLNYFTNFRDLLPLIEYHYTFKNIKNASAVILHSRILDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC8</accession>
    <name>A0A4Q9LXC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0430p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000430">
        <property type="protein sequence ID" value="TBU13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0430p0040"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="50713" checksum="5A21507E437479DD" modified="2019-07-31" version="1">MSTMKRRIVIEKIKLNKIGLFSFIRRYKFVMCISDKIGYIFISSDETIRVRIFMDEILLNEFYFEYLCVDSLFSYLEFKDEYKLENTVDNELKNIELKDKLKDEYENKGDNEYENDFDNKLKDELKDEYENKGDNEYENKVDNEIKFVEEIKYYENNFCAFKVYDGRIYYLDYSDLRISWNKIENRFKNELPCRWEMKENKDGNVFYINHNNCTTTWEHPIPSYRMVRVVQKMEKYIFYSKFRDFLYPFNSQIISLSVKRNFYVQSTALKLIESTQADLLKNIFIEFIDEIGEDHGALLREYFYKTSLEIAQDYRIQDVGSFYDVKPMTEQYFKDVEYLITENLKKYIKIKNKPKNKFFLKSEINEYKGENKAENLKNKIGNNYLENSDKYSCEDKDEIKYLENNFQSQKYHSSNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD9</accession>
    <name>A0A4Q9LXD9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0431p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000431">
        <property type="protein sequence ID" value="TBU13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXD9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0431p0020"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="523" mass="60739" checksum="3E7E6611F5044B16" modified="2019-07-31" version="1">MAGHNSDINKVLSNIELQERYSNSNETYNSKDSININKELVIKELPNKERINIRSNYIMNKDMIDGKNIINSKVLNEQSKVGGLPNTLFEVKNNFEVKKFIKDANTNNLYESNRNYNLSDVNNKCDNKSESDIYRIINNFTMEYNKSKEDKVLIRNFIKNNKFEEIINTQDLENNSFTNIYEKDLLNILKSKYEINCTNIEGISDSYFIKKRINLYKTEMCRSFEETGFCKYSERCQFAHSKSELRSIQRHPRYKTETCRTFWEEGTCPYGKRCCFIHMENKSLNKKSESDIKEADTENCDSNTDKNYKEKESNIPDTISNVHKINSEYNIEATESILSSLERNHESISKFCLSKKNEGIKDDNFVAIDNSVSSNSTEIQNSLENQIESFETFGIDINDNEIPDTFLNEIEIKNIKDNSILFGKTQNNNTLSESLDKNESIETSDNQYNETKLSSNIDLQNIKPFHFTNDADIWLNGIPSLCFIKTRNRRYHGVSLQPKAPGEPVMPICDEEVAEFVLKHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM3</accession>
    <name>A0A4Q9LXM3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0748p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000748">
        <property type="protein sequence ID" value="TBU12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0748p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="44189" checksum="9C4398BF6868FF3B" modified="2019-07-31" version="1">MLLQLLDCLEKSKETSTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVKPRDEAVFCYIQNRISFLGAEGMWQHCNQSRKTVDHLATRCEKMLGHDYTRRQNEVVRCIHLLLLNKYKFKSSKRIRSHSVQKILDNEYAEIRVDTRIKTDFKIRNNRPDIFVLDKRRNKITLIEVGITSQYSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVETISFDRRRGLESGLNADESWERLLMGEDGLKTEKKENNTPIISQGGTNNKHKSRISFRRITDCGTRVQRKCIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM8</accession>
    <name>A0A4Q9LXM8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0396p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000396">
        <property type="protein sequence ID" value="TBU13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0396p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21878" checksum="3FBD94008C257A61" modified="2019-07-31" version="1">MKFGKNSSKHYIYLKRREYEYNLANFELRKHYMTEEQFFMESVLLELEYNLFECDEKDVFEYNFEIYGNQIYLFDEYNPDKIKESVFVDDASGTDENLLPENTKKYKKENKNTISSQRRAKIFRCNNSFCNKKYTSSYGLKYHLIHGHGSKTLKKYVCDETGCVKSFKNPNGLKYHQKFGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT3</accession>
    <name>A0A4Q9LXT3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0379p0060</name>
        <name evidence="2" type="ORF">CWI38_0384p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32749" checksum="3435B1EB6D78D59A" modified="2019-07-31" version="1">MNIRNDNLVNSENSKIKHYKNLILVVLLGIVLCFVCIVLACEIFASSGSKKNDVLDDNIICKKIRTEFIKTLKEKYNVGILNFKFDENTTQGNMGLINQDFRRSLVVVNSASSDLLPGESGLNGGITRWVESKDGINDDIWKNFELLKHEEDDDENEDDDENYGYYDDSKDLADSISGISSFQYGFIFHVRAPDASSVGRENRFKDLKELREAIKRIYVDILRFARYKEANTVVFPIFSESFNCNIKASQNFKKSEFLTAIYSGITDFITETDKNEIKIFINVFCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV3</accession>
    <name>A0A4Q9LXV3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0713p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000713">
        <property type="protein sequence ID" value="TBU12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0713p0020"/>
    <dbReference type="OrthoDB" id="2190427at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="322" mass="39257" checksum="1617A9AF8D9B5F31" modified="2019-07-31" version="1">MNKWVNNFLMISQIHPDDSDYEKFYSDILIFLQNNNSNHIEYLKIFTTGVETFHNKTLISMCYRLINSLNKECFESQVFISISLLQKHIKSRILRSHVFTYIFNTNLLENFKKQIIKFLYDPVEEFNGLPLVLQHKYFEKEIDNFLSLNDITIYSKQVFISIKMGVFHNLDLFIYHFGNENNILAFKTYELFYFYIKKATTDTFQNFSIKDNKYICFTKPIKVSSIENFVFHFFDFIEENEILQKFYIQNDYESIKQILKKYLILDKEFKLEQRMNKCFYKKKEFYNYENINDINHNIESDLDYDYLFDRNTYKQKMDCIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW9</accession>
    <name>A0A4Q9LXW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0707p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000707">
        <property type="protein sequence ID" value="TBU12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0707p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8013" checksum="95FC7630D19DBC2C" modified="2019-07-31" version="1">MLDANFQTRLSKGGFSRFLLEIINNYSPVFNLKIFALLYGPSFSDSNFDGLTEHLVVGSSLLKIQEIASTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC5</accession>
    <name>A0A4Q9LYC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0448p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000448">
        <property type="protein sequence ID" value="TBU13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0448p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="33426" checksum="8BC21DF8CF4775D9" modified="2019-07-31" version="1">MENFISLIKNKIEENSKRIREKERKAKEIERRGEGVKQLDNLISELEKENLFADLEDFSKENITNEDIKDHSKEDISKENTTKDNTTKDNINKENTTKENINKYNINKENTTKDNTTKDNINKENITRDVNTTIPTDTSTKEVKNIGSEHLVELRDVFVSVKTWFENNKENKEIGHSEFLNQFVNLKSKHRIITTRIQRMKEEKERIEKEKLEKEKLEKEEKERIEKEEKDKDNKDKEKDNKDKDNKEKEKEKEDIPTLPSEENEVLPPFNETPSFEKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ2</accession>
    <name>A0A4Q9LYQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0303p0030</name>
        <name evidence="2" type="ORF">CWI38_0519p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000519">
        <property type="protein sequence ID" value="TBU13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000303">
        <property type="protein sequence ID" value="TBU15970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0303p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0519p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120568" evidence="1">
        <location>
            <begin position="23"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="561" mass="65969" checksum="4D06DFF8CEBF0BF1" modified="2019-07-31" version="1">MKFLYSLRIILLLNGINLILTAISDSIQVGDQDIILDESLLREIVLDKEEYQRNHSYYNSKKREDEFNNKKGCNTAVRLGCLFRMSTDLSKRHNNDLETNSTASGSIQSKTVSLFVIPYGEQISDHNQYAFEVSQAYLFNPLENPQNEFAYYASDRYPQFIIHYLLPPPSNDYYLGDPGIYFPSYECNKSFTATDMLNLILNRLYFTSNFMNLEDLLPLLQYDYLFTAIANKDTYVEHLITLENISYNEITIKYTTNITEKELEEYWKHFDRKYSSIKIIDYDSPLISYFPGIVHLKEFIYNLLKSLPLRRRNIFSVFVGMKMIESLLVSSKEIISSIIKDYVHDMFSFDSDLKKTLNFHKKILFKIMKVLLSKNFDLSEEFFISLRIVETRCIYLSKDTLYINGKYNSYFLRALIDSIFLLDEQLNKNVFGFFANYIKSVNLKTGFVDHNFIDFAAIYKTELDPEIVLKLIKYYLEMLRKNEFMGCRDIDVFMFNSVIISLTDDAGTLEEILRRKCLGETKMHIDLLLKCINIFNFIIKFGFNRNIHNILYLKSMSEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK0</accession>
    <name>A0A4Q9LZK0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0209p0040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13"/>
    <dbReference type="EMBL" id="PITK01000209">
        <property type="protein sequence ID" value="TBU19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0209p0040"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="14">
        <location>
            <begin position="167"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="34626" checksum="C5145C116FB541DA" modified="2019-07-31" version="1">MTRKEGRAISHPNIALVKYWGKKDIEMNISSNMSVSLTLKNLETVTVVSPSEEKRDIFILNGHERPMKERMIKVIQLFKKRAGDVSYIKIDSKNNFPDSCGLASSASGFSALVKALNNFYDLNISTPELTEIARYGSGSSSRSIYDGFVCLDGVKSFKVSDWDDVKVFVILLEDTEKKVSSTEGMIRCAKTSNLYNLRLKYINYKAQEAMEYIKNKDFTNLAVLTMKEANEIHAIFMDSYPPIWYLNGRSFEVIDKVFELNSKSIKAAYTFDTGPNPFILTLRKDFEEIFNHFKNLGFKVIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZQ1</accession>
    <name>A0A4Q9LZQ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0302p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000302">
        <property type="protein sequence ID" value="TBU15972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZQ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0302p0020"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU15972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="707" mass="81046" checksum="97DBFE4C69D8F811" modified="2019-07-31" version="1">MTNQQKFGISIKKEEDFSEWYCQVVTKSELIDYYTIKGCYIMRPLSLFIWTKIKDFFTKKIQKLNVQEYYFPMLVTKSSLEKEKDHIENFAPELAWITSYGNVLLDNPVAIRPTSESIMYPCFSKWLRSHRDLPLKVNQWCNILRWEVKSTTPFIRAREFLWQEGHTAFLTKEESDKEVLQILDFYSQIYQELLAIPVIKGIKSENEKFGGALYTTTVEAFIPGSGRGVQAATSHSLGTNFSRMYDIKVTSEGNIGNGIGGGEGGEGGEGKNKSKDKNKTKSKSKDSNTNTKDNPNTNNNPNNTNNNIPLKHSSDSFVHQNSWGITTRTIGISTMIHSDNKGLVLPPKVAMYQVVIIPCGITVGRDSTPLFRYIQTITKEFEGGYVGCGCGEGCEDSMDNTYIKDSKDIKDIKDIKDSKDIKDNTKDIKDSKDIKDSKDIKDIKDIKDSKDNTTHTHTHTHTHTHTHTHTHNHTPQPIRYFLDDKTNVSPGYKYNYWEIRGVPLRIEIGFKELNNNTLTVIRRFDGKKIILENKNIFKKIKNELNEIHRLMYLKALKERDERIIRVESYYRFVEEIENGNCVLVPWCCDKECEEELKRRGGVEGEVGMDSNKDSKDISKDNTRDNKNNTSDNTRDNTRDNTRDDTRDNKNTRDNKDNTGDNKNNVLTTVPLGVKCMCIPYDNEDVSDKKCFNCNKSAKSLGLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M003</accession>
    <name>A0A4Q9M003_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0173p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000173">
        <property type="protein sequence ID" value="TBU19920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M003"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0173p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="9083" checksum="42C5E442410C1E3C" modified="2019-07-31" version="1">MSFLYFVVRTTKINPITSSSSFDTCYKQQCGIMVDDMLFRVNKPSVPRDHRDNYCNEIKDKSEIGRKEKEICNKRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M061</accession>
    <name>A0A4Q9M061_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0162p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M061"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="27075" checksum="64612246B30A662A" modified="2019-07-31" version="1">MKDLLIETPKPKYYFKFYTNAIFILNYQIGVLRHKPTDFSTLNDAACLGLVGNIIYIHPGINNSRDNELVDCDEAVFCYIQDRNVFWCTEGVYQYCNTYRKTGVRCKPGLLLNRYHFGSSNRIGSHSYKKLDNEYTEIRIQLSANKFILIYKCILEIISYLLSETVLLTRSFEITQEDCRNDFRAPLGVIKQVEMHKRPVPLLKEVYNEENNIRRNNIKEIKFINLNFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M078</accession>
    <name>A0A4Q9M078_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0282p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000282">
        <property type="protein sequence ID" value="TBU17618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M078"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0282p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="59818" checksum="F8D356166CEE2BA0" modified="2019-07-31" version="1" fragment="single">MGVSICKRRCFQNSIFTNLISIVYILCFFKLVSPLVLSYRLQSIKHSKILIFDEKKQNDLLFDQNSKYLNFYVLNNLESPSCDEITYDFIYSKENFIGFEVFDNFLNSSRMENVNMKIECDFNLTYFLRLTNDITNISSKINYQVFDCLLFAMKSLDVIENKNLKSFFQAILFNFLYFNNNGYFHNNATSFKDPFVSSLLLDIKYILKKNLIFAYLNSLMIKYIFYDENLILLEKNNETYNKKHFDKHIPYKSLLINSYKAFQILENILNNPNILHMLEFLLNEMNIKSIIFDNFQIFKILDSNMKIYILSMNIFKSITISHFKWSSSWLFLRKHIFSDKKNIEFLSLKNLKISKSDLEVICKKQKFKGLVLHNIKILENTNKNDLFFGLGVRLEYINFKNVEIYEGWWKEFFQLVHIRIIIISFYTYSSQEKFIKEFIRVNTLNELLYLELDFCYSSISKDFYNSLHHFKSLVTLKLYGYKFDQNTHFFSHAFESMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M090</accession>
    <name>A0A4Q9M090_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0152p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000152">
        <property type="protein sequence ID" value="TBU20009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0152p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020259187" evidence="2">
        <location>
            <begin position="19"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="757" mass="88803" checksum="7382EADB5842969A" modified="2019-07-31" version="1">MFIYIFIFVAIFLSKNKFTNIPEDSLIEQSMYMSISYNLVVNNNIVEKYLEELNSKIDSNKKNQIVKISSFYFREIQDYTDKSSHEFLIYYTTLICYIIYYNDNCSENYKKFKPELLFNLIAFGRFVEMYKTNNDISSIVKVVFSKFVANTIYCITKGKDYNMLKKGDLGISTAIEESLKQNNQIDEKVVVYSKRLVSDFDREDFANTGALLSNATMEFLFGFFSILKAKFFQQQKFENTKSLHNSNHNKSIKLYSKCIEQNVRALYEDLDAKLNDTHYKKAMAYISEQIIYRVLKDNSTFDKIYEISKKTISFHIKQQDSNFCQVFIELFCEEAVLNQIRALYDFLTAEVKEEWHKYLSAVLSLKTFCLKKEITDKKTMIKKIVEFLFLADVLKKEFEKVEYVEKIKNQRKTFIDILKTIFEQRKIEYDKNTQGDSLDCIKVPKTANLIEIYCFIRLFFNDDYKKHLATQINQNFKQKLNIIGENFNQIKYKYLIYVFDTEISRLTPDQQRILFGPASKKGSNPKSESKSSNNFGLQEILDNEYAEIRVDTRIKTDVNIRNNRPDIFILDKKKNKITLIKVGITSLDSLQIVETEKLRKYDLLAHELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYLQSIVLKKTVETISFDRQRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINEESDLEKETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E3</accession>
    <name>A0A4Q9M0E3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0368p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000368">
        <property type="protein sequence ID" value="TBU13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0368p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15217" checksum="758990F9684EE7E1" modified="2019-07-31" version="1">MPCHDYTKRYNNLYDAYIYSYRSDIILSFQNEFGPKQYEVLENLLGIIYKCTVEIVPYGINWNGIDREISKKVPGIIERGVWPGKKDFYEQLKSKKIGHKQVNLKNIFALILEGCLLRPELLIYFGVTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M139</accession>
    <name>A0A4Q9M139_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0087p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M139"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M139"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0020"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="896" mass="99888" checksum="52765BB7325982B0" modified="2019-07-31" version="1">MVDLSIKKVEEMMKNQLNIRNISVIAHVDHGKSTLTDTLVIKAKIASQESGGGRYMDTRADEQERGITIKSTAISMHFELPESVLKGHLNQKHNGNEFLINLIDSPGHVDFSSEVTAALRVTDGAIVVVDCVDGICVQTETVLRQAVAEKIRPTVCLNKVDRALLELQESKAQLYARFRRRVEDFNAKLQMITLGKEDSRFPIHNLQPELNEFSFCSGLQGWGFTLRQFASFYAERFNVKDKPEGEKRICKMLWANDVFYTAEDPFDTTGTFKKQGSPEKAPFIVFILNPIYTVRDYCMAVQHENLRNFLTKYNVTLPTDLPNEPKTLFKLVMRTWLPAADTMLEQIILQLPSPVLSQSYRYDSLYEGPVDDIVALGIKNAAVDSFKCSDQMSSEMMQKLNIKVDANNNAVDANNNPIDANNYMVDVNNNVVSAPLAVYISKMVPYSDNRFIAFGRVFSGKVTPGMKVRVQGPDYVPGSKNDLFIANIQRTVVMMGRTVKDVSMCPAGNIIGLIGIDDKLKKTGTITNTDVAHNIKGMKFSVSPVVKYSVSPLNPVDLPKLKAGLAKLSKSDPLSVVNFSDNGELTIAGAGELHLEVCLKDLEEDYAGVKIVYGEPCVSYLEGIRNSVLEPKMCKSSNKHNRIYMTCSSLDPAVVENLENGKLVVRDPKERVAAFNSVLGIRDDWIKKIMFYGPEDKGPNLFVDATKGIAYLNEVKEYLREGFRDVTSKGPLIEEKLRGVRFELTDMVLHSDAIHRTGNQITMPVSEVCRGLIMAATPVLYEPIFRIEVNVATEAMSEVIALLATRRGDAEEVKEDGSSRTNIYGILPVKESFGFNAALMKVTRGQASSSLCFSHYEVMPGNLAMEGSLMHEVVTTIRNKKRFGKLKSADEYFDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A3</accession>
    <name>A0A4Q9M1A3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small subunit of replication factor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0074p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000074">
        <property type="protein sequence ID" value="TBU20415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1A3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0074p0030"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="292" mass="34235" checksum="3376B91CA7628CEC" modified="2019-07-31" version="1">MNNTLWTEKYRPKTVESFEGPEYLKKFIKNTEENSFPNLLLYGPPGTGKTTFAHLLIKKDFMELNASDERGIGVVRNKIKVYAAGISNEKTIILDECDSLTNDAQQCLRRIIEDHSKTTRFIFITNYLSKIISPLKSRLLKIKFECKKENVKYLKKIGKLENLDLKEEIYDKIFLFCNYDLRRSVNLLQGIHPLVNENIDFDEFMGIIPKNVINKFFSLRRTNEIKYYVDEFIRNGYSLYQFLFQLADACDGKDEERCMFYKELSLIESRAVLGCSTEILLYSLCCKKLEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E9</accession>
    <name>A0A4Q9M1E9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0066p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000066">
        <property type="protein sequence ID" value="TBU20465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1E9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0066p0010"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="84"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="282" mass="33234" checksum="2565B64700FA4087" modified="2019-07-31" version="1">MKTLEDRIKSTSTLILCFYLHILTQAIYLLPDNWNKAKITYITIFNVSCTMIYIYLCLAHINKGFVIKMSESELYLLGGDIKRNGKFCRRCDLFKPERAHHCSRCQKCIKKMDHHCPWIGACVNHDNLGYFIRFLFFGASSNILLFGYLMCIFVRKINEKKFQFGIFYTGMVFSLLLSFSLSFLLTFFFIFTFRNATKNITYIEKLRYSDLKKYGMDINDNPYDRGAYKNIKDVLGKPKFLFLCGEKQNGIFYEKTYPCSEWPPYKFGRSVDENQIKDSDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K5</accession>
    <name>A0A4Q9M1K5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0154p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000154">
        <property type="protein sequence ID" value="TBU20007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0154p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020260067" description="FCP1 homology domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="56894" checksum="9293A25938EFB337" modified="2019-07-31" version="1">MNGSFLLTLYFLRIYTAAVNKEKTKRLYNDKIRSEMLNDPKHNFLCKIIEEKLDLPYPPIYDQNLNDSFFAHYNLQHLFEYEKDIMKLFIFLRDEESVKWILMFEIRILYTFFSFFKQYLQNYSEKFNEHPCLQNMLKRYVQKNMTIDMKEYDKSFSERRNMEMKILKFDLEAYFEKENAVLASENDQDKTKINFLDKKCSISEDKKTHETENSATFGSPLDSILICSKEQFDRQDFNKENLHANSDSKSYQPSVEINIAADQRDVQILNPGAIDVETDGIQPDILNRIYKSDTKDGLRLYMENIFKNLFLSNSPISSENTEFSHYKKSNAYKRHKEMCKNEKLESTDTIFSFFYKMLFLKYESQWKDLLSFIPATSYMGYTNILAYLDDFILCLDFQKEVTNETFFISIEDSVFPKMYLDEIVLVFDIDDTLFPTSYWTNKYPNFGMDESYESSDSILREIVDDNPKKEDICNSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P3</accession>
    <name>A0A4Q9M1P3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0240p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000240">
        <property type="protein sequence ID" value="TBU18501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0240p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="55655" checksum="4B39BC781E7FC9A6" modified="2019-07-31" version="1">MKIEDINESNINSLLLHISTDKNLYNSCTDTLILYLLYNYNTQHDIILSKIKILLLGKRNKKNKNLHEDRECDRGSDRDEASDEGRDDKKDRKRRRSKIRHTKAKHTNHTSDKEFNISFNSNKIINKIFKIILKIKNKEIEDSAIETSLSVLEEKSLVLRETVYYYFESIYLSCDEVSEYGIEVLKRILSVYKIEFDNKDVDSDNDSRCIDNRSADITNTTYINTNISKIKDTNVNPPFKISKTSQNPSEDGLIDITNMDFDLCKENNVFKLNLKKKGDRDVYIEKLYKLLTVILSGREYKGSIMFLMLILLVNKVEEKKSLRKLIKVFFMGVSDMLEVLRECYKGVGKYGIFILNRVIYECRTRNIKIKYKKMLKMVGFLEIRNKGVISGVDWKDLRLSDMRRVFGKFKKPGVFIDLCKKLIKRENDVKKIQKFKETVISVSEKKLSNYDYKRVNILKDFIDRKLEVCNGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T6</accession>
    <name>A0A4Q9M1T6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0033p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000033">
        <property type="protein sequence ID" value="TBU20694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0033p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6535" checksum="6C940529191F9FAE" modified="2019-07-31" version="1">MLELGIGLTTHPLKLPAKARTRLSKVPYETFSNPQFIYLVILHSFIMMNQSVQLAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U2</accession>
    <name>A0A4Q9M1U2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0231p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000231">
        <property type="protein sequence ID" value="TBU18735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1U2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0231p0030"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU18735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="37672" checksum="D1354E926B9EF418" modified="2019-07-31" version="1">MNEISILEKLNHPNIISGRLFSNRFFYYLEMDFFEYDLLGYVKRNFLSIFDKKIIVKQIIDALYYLKLKKIIHNDLKNNNILIDENLNIKICDFGLACYKSRLDFPFNNISPSALEEYEVYSPELKQSIEYGEKSDIYSFGILTYFIFQEFNYKFETFIPISDSESNNMFLECIEYNPMNRPSVESLLLSAYFDFLYDKMFCFGKLEDFTIETETGSIIKKDKKLTINIKSKRAVEILCCCHILTSLRYTSKAKKLNLTENRDSHSNLDLGFTQLTKKRFLYVDSDRTLKPIQFMTQLDRIEYLDFFYGNENYQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M201</accession>
    <name>A0A4Q9M201_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0156p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000156">
        <property type="protein sequence ID" value="TBU19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M201"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0156p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="613" mass="73602" checksum="CA17FBDAD26573D9" modified="2019-07-31" version="1">MKFGKRYSHRIFFNFSFGFYILFFVYYSSERDIVFNVLIDNKDIYSNSIVTETECLCQIKRGSILDTKVIDCFKKMLFRNENRQYNQYIIKDTDKFSHNFEPFEKLKDMNSNIEIFLCQHIKESDFLIFYSVLISCYLMNEEINIHKFYTILYFIEYFRIKLDNILRNIIKTILYSLANSNNIIHFDVHKKMIYFSKQDYFSHECFKIISQEYLKMLNSRADFFSPFFVKKSYCYIDYKYQAVYTEDRQKILSLGYEFRMLFSERISGNRKSINLFILILNTLDIKYVHISELNETNVTDYCLVLTNIKKKVEEILFFKVYIFSEIIRCIDANLNFINIKKIVFIRSKIENYLILLDYLKKISEFIFFEETRPTKPKTVTQINYPENLKLIKEIEINIQRHGYPEYSLKKLVTYLKNMPLENQNLYVRFFEANENTSKFKLLEVVNIVSKYWKIGCYFDYKGTFYNISITLTNLNLYQFTPKETILEENIKKLRITDSKITSNFVADILNINKLKSLTIKKLTHLNFNFTLPENHIIESEPNPVSLQNLFQNFDLVSIKKLNLEWLSITKSDSHALNNLLNLEQLKIEMICLNNIFFSELFCISTEYKIKECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M284</accession>
    <name>A0A4Q9M284_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0015p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M284"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="23031" checksum="2F10D89FA0A41C37" modified="2019-07-31" version="1">MGKNKKKSKKICSAEIEENFANLLSNNESSSETFNDNYETASNNINLSLESSESFEVFDTEVTTKFSRNDDDLVLKPEGKLRLVEKKDNIQIYSINRSLFDLNDFRPHNNKIKKIKSRKKYDFSCLDKHNNLFKKLGSLKYDFEFNLNETYKSSNIDTNNLNINNTCENFETTTEKKCINRPKTFQFYKKNKNKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M326</accession>
    <name>A0A4Q9M326_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0132p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000132">
        <property type="protein sequence ID" value="TBU20102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M326"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0132p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18745" checksum="70D337C9C5C37B68" modified="2019-07-31" version="1">MLNLLGIKLYKNNNEPPIESSFEKKKELIILKILILIYKEFNELSLIYKCRVEIISYVMTWNGIVTKYHKSHLKRLEIPMNVEAYIMYIVLKKTVERTSFDRRRGLESGPNVKKSWERASMGINNQHSFKATEKPTINANEESKLEEEIEVVEIVERNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M348</accession>
    <name>A0A4Q9M348_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0131p0020</name>
        <name evidence="2" type="ORF">CWI38_0168p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000168">
        <property type="protein sequence ID" value="TBU19936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000131">
        <property type="protein sequence ID" value="TBU20107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M348"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0131p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0168p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036357712" evidence="1">
        <location>
            <begin position="19"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="776" mass="92677" checksum="5F243D9C452C36A7" modified="2019-07-31" version="1">MLSISLLITTYILTSSLTSVTFYILNEENRVKNLINTDLTIDMMFLDENIEYFDKNNEITIFKNNILRHESKFEITSYYIPNTLTLPYSHGMFLNSALLKSLFDSREKNIRVFINDVSYDNFLLFLKLLDNFDALINQINSKAFIDILTIITMLEIKKSKQRKEFIKDLLRSLLYGINIFDFDFKRDYYNCVYNHIKRSILRDLIVFFMEFIYFDEKITKSYIVITDCNKVSFKKDSCSLYENCIKKIQKNKIYLRLNDHNVKKLSKFMVSYNLKNTWIFLFKIIRIDLVYFVFDLEESFEIIFKLLFGVKFYTEKFYFHSFKNATIILLKIRYHLFLKNLNVLKFNFNFNLNELKQILSLYDNVKKITIKTHEINFGTLKFLISYCRDNSYKSFKVVSFSYNSLNTDINVLKNIPANLLFFAGCDNNGVEIKRISTSYMPFMYNNYYSIPQNSFKSCYNIMFWECINVREIKFWYDETLSSAKLDDSIFQSLRYCKTLKKFSVRNIELTDKLLVYILESTTLIFVEIIDYEWLFDDQFFLRTNTLNFDLKVFSFEDSKSLIEPDFMLYLARFRGLSGLKFYYTEFYLRKKYFENFNDKISMFFSKKACNRIYLKNLEIKGSSLHPDTKNCLYFLSDVYDFANLQSISISSYGLTEMDYDFFNKMNKLKVVIIKSIGESERIDFKRLFNNKELFNTVIVINISVSKITSDNIQTLSCFRNLMGLSISSPLIDYATIQSIRRKYFKKTDFVITEPIRKDRSSFINQYLDSEFIYGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3E6</accession>
    <name>A0A4Q9M3E6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0132p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000132">
        <property type="protein sequence ID" value="TBU20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3E6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3E6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0132p0020"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="32190" checksum="AF86144E2E92B1DE" modified="2019-07-31" version="1">MIILNILSKISRVCASFSSRSYKSSSSRVSLHSGGGSSGGSSSSRGSSSGGGSSGGGSSGGSSSGGGSSSGGSSGSGGSSGSGGGSGSGGGSGSRGGSGSGGGSGGSTALVKNLKIRDICNKIGFEDSSMQKDNNASPIEVSLYKEYWKTLNTMTIHNDTNPYTTNITSQCSLTLRKGYILEAIITAIPKVETTNKINYALIESFLKASIEELDYKNIQQNIKTEKLSQSYIMQEKMILCYIKGRNLLTQEILENEHAEIRVDNKIKRNVKIQNNRPNTIVLDKKKNMIALIELGITYRDQLHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Q1</accession>
    <name>A0A4Q9M3Q1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0125p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000125">
        <property type="protein sequence ID" value="TBU20146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Q1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0125p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6093" checksum="2B1F1C7FFDB3F85B" modified="2019-07-31" version="1">MTFMTWQTLLSTSYNTFVNNLAHSVEFAQSFIKSWDISLVKDNDRMTEEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4J5</accession>
    <name>A0A4Q9M4J5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4J5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28732" checksum="C10F5C921683E378" modified="2019-07-31" version="1" fragment="single">FCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIKSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELDGIVTKYYKYHLKRLEIPMNIEEYIQSIVLEKTPRPNTEECYEIADLINNQEDGAKHLKGKNDTPLISERGITVKEPTNNITEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M538</accession>
    <name>A0A4Q9M538_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0133p0050</name>
        <name evidence="8" type="ORF">CWI38_0014p0070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000133">
        <property type="protein sequence ID" value="TBU04454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M538"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M538"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0133p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0070"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU04454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="189" mass="22495" checksum="CED710F81674C88E" modified="2019-07-31" version="1">MKLRLTNLNDLNNQTQNENLEMKYLMYNRTKSALRASDVSKMNQRDVEMIELLLSAENNAYFKKKREKLHPETLLQRFKKDFVKDFSCCTEKFENFDYYAIHLRDVHNIFPEFDSLRPNKFLGDYQEEAFFDALFFFDGFNPNLPISKPQVIKPYACSVIGCEKSYKNQNGLKYHVEHHHKDLFADIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M545</accession>
    <name>A0A4Q9M545_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0013p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000013">
        <property type="protein sequence ID" value="TBU20882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M545"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0013p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="61" mass="7418" checksum="9884B8995891C43C" modified="2019-07-31" version="1">MHIDFHWIANETDFEFKSSDFFLFYKDGYLFQGILLYNTNPQITLKNDRVIFTEYLDDIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5J4</accession>
    <name>A0A4Q9M5J4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0019p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5J4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5J4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0070"/>
    <dbReference type="OrthoDB" id="8949402at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="515" mass="58008" checksum="C8BD5A35497FB036" modified="2019-07-31" version="1">MSIKYTICIYFVFRIVYSKLECKNSNNLKRKFECVISNYIPNKENNILNISYNNCSSIPSKHDTNKKMCKKITKKVITSRSNPSTDRLNNQKSNVTFIPQTNKKLPSNRLAYITASKTGKDNLISKKNLSLKILPSNLEENLRKKIRLGVIPYGILNSNYKNDSKNSKDSIFFEEKPENLFIVNNELNYYYNYNLKDLLNCRGVSGMSGKCKSGNDGVYMVSRCNKASFKDGGSVYKVNSFKDGFNEVDCDEGGVNDSGNFVKVTTLKEGANELGSDVGVNDSGNFVKVTTLKEGVNEGRSDVGVNDKESILKVSTIKEGVNELGSDVGVNDKKSIPKVSSIKGGVKEQRSDYKGVNENGSDFKYNSIKRGVNELESHYKGFKELGSDFKGVNELGSDYGGFNELGSHFKYNSIKRGLNELGSDYKGFKEFGSNFKGVNEQGSDYGGFKQQRSSYRSFKEKRSINRGVNDKYIINNYNNIKRGLKDKDSFFNGNIYRLGKNEDSNWFSDYFNLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWT3</accession>
    <name>A0A4V2JWT3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2176p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002176">
        <property type="protein sequence ID" value="TBU09172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2176p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="22939" checksum="B56873C144314CD8" modified="2019-07-31" version="1">MLGHDYTRRHNEVVKCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIFLNVEAYIQSLVLKKTVETISFDRRRGLESGLNAEESAERGSMGVIMRAEMHEEPTPPLKEEKREEDGVKTENTENILPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY92</accession>
    <name>A0A4V2JY92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0110p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY92"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0070"/>
    <dbReference type="OrthoDB" id="2193657at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15740" checksum="071CE2ED458F9A81" modified="2019-07-31" version="1" fragment="single">MNFEFQPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRKELGRNLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSLIKNFLKIKYVLEEEVTKKKLEEAQLANLYNEIKIRKLHSKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY96</accession>
    <name>A0A4V2JY96_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0098p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000098">
        <property type="protein sequence ID" value="TBU20273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0098p0010"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="2535"/>
            <end position="2690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1934"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2318"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2362"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2987"/>
            <end position="3016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3142"/>
            <end position="3166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1804"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1939"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2318"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2362"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2377"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3142"/>
            <end position="3153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="3235" mass="363758" checksum="987A8D486411BA52" modified="2019-07-31" version="1">MSNIDISLLLKKYKYYSKLSKTHLNTLISSISTQPTHIQHTLSYFILENNTHNNDLNSKYREYINPCHENDIIHCNNTSCTTKDIIHCNNTSCTTKDTYNCNNTSCTERDIIHCNNTSCTDKDIIHCNNTSCTDRDIIHCNNTSYTTGDIFQCNNTPSYNPNLNLTLNKRINIPTNTLLLYIFNTISPIKIHNIIHTHPYYFKNTCTYVSKYIDIRNICPYILKYSSINYKCYCRNILIDLYFKFSTIGLHNFNLENEILLEIKNIIYSYIKGVSNSRDILEGVSDSRDILEGVNNMVYDYKGVSNRVSKLEGVSDSRDILEGVNDRYCYIKGVSNRVSKLEGVSNRDSKLEGVSNSSNNQQGVGNSTNNQQGVSNSSNNQQGVNNKDIQEPFNHNLNTQHPLNNKTLYYHLYTLISHNIEDNNLFKLLYNNTSIYPLIYWLASIDMLLTLSTNEEVLNVISNKIIRNKIEVSNMVKGVSDIEMLEGVSDSIDYYKGVSDWIDNYKGVNISTNKQQGVNISTNKQQGVNISTNKQQGVNITTNKQQGVNITTNKQQGVNTNTNTPVIDLYKSFIYNNPFSINNRGFKLPINILIYSSLRISTYNENNLLSYIFKKEELYEEFVVLLGKYRGRVMYEGKGVLNNSNVDKGVLNNSSIDKGVLNNSGCGYIENKGVLDNSSIDKGVLNNYNNHKDCINRKTINIEKNKKCIKIEKNKDLFYRFKHFSLQSIHSFINENLLILEEVVPFIQRISSFLPPEFPILFFSSTFNNSYKLFYKVFNKMNVIDMNDILFGNENISQYLPFINLDESGNSYRGVNNSGIDDRGVSNNTNKQQGVSNNTGKQQGVSNNTGKQQGVSNNTGKQQGLSNNTGKQQGLNNNTPKQQGLSNNNNTSSLPNNSFINIPLISSLIHHPLFIHLMLTHSYFNKYINNSTFILALPFTEIRYLYFTYKLPLLGYLQNIKCKEYMCIIKGCNYKCKEHLCDKMYFEHDTVCYEGCKCVCSYMGVNDMSMLWGVSNKEILEGYRDKDMLKGIEYITTKLQGVNLNTDKQRDVNYSTNKQRDVNYSTNKQQDVNYSTNKQQDVNYCTNKQQDVNYSTNKQQDVNYSTNKQQDVNYSTDKYHPFNNRDKDNIMLIRNIIPLIDSINNLLNNNTLLLHSVIEKLECLINSLKNNTPLFYYTTNRLLIEHFLLPLILIRVIPLIVDNRCYSYLRFFLENTSSSFIHSMCYCIGIENIDVMSECIGVLSCDVDKVLRHVIEHEKVCECLRCVNDRGISEGVNNRDILESVNNRGVLESVNEQRVLEGVNDKNILESVNNKSVLESVNDKDILESVNDKDILEGVNNTTNTPNFLDNNTHPLTNTPIEGVIPVETLKEYLDSPFSDSFISYISKHYPLSSILLLTPSYLHTVLIQHLKYFPKNNLEIIKYVINNVSVITNNNNLLINSFYIPFNELEIFKYLLSIGNIELLDIFIRQREIYYRDRGLEGEGVLVGEYVSNRDIEQQGLSNKDSEQQGLNNRDSEQQGLNNRDGNQQGLNNKDSEQQGLSNRDSEQQGLGNKDSEQQGLNNKDSEQQGLSNRDSEQQSLSNKDSEQQGLNNRNSKQQGLNNRDGNQQGLSNRDSSQQGLNNKDSEQQGLSNKDSEQQGLSNKDIEQQGLNNRDGNQQGLSKSTIQQQGLNKSTIQQKGLSNRDGNQQGLSNRDSEQQGLNKSTIQQKGLSNSTNTLHPSNTTDTIYNYKLLILNTFTNPTIEEGVILYNIYKSINTTPSIKGNLIHQICTTKYIKLDMSNKVGDKGSSVEGSNETCSREGVNIKDSKDYNKDNKDSNKDNKDDNKNNMDNIKDSKNIYKNNMDNNKDNISTLILTPSIYNIYIISKIRPSDISIYISDILNYLVSSLEETDNNSNTSIITGSILGSSNNSNTPLENSTISNTPLENSIVNNTPSDNSTISNTSLNNSTVNNTPYNNNTISNTPLHTSTLNNTPYTTNTIISSILMIHFSNELTLFTVIDEVLYLLKNKKEVIRYYILKNINSSVIPIEYIYRYIKRVIILFNDTSYRISVISKDILKGVNIMTPEIRSIWYLVVKSMYSSGGLGGVSSNGGLGGVSNKGSRLEGVNISSNKQQGVNTSTYKQHPLNTTSDKQHPLNTNNNNINTLIHTLFNITYNHYWDSVSVTCLLHVLCTYEDKRVYDILKGLKYLCGYDVYISVVEGVIDMLVSRITRIGKEEVLLLESIIKDLKCNECVVGGVSDNRSMLEGVNDKSMLEGINDNSSMLKGVNDKSSKEEGVNDKSMLEKGVNNNSEIKGVNSKTMLKGVNDKSMLEEGVNNNSEIKGVNDNSSEIKGVNNKSSKEEGVNNLSNIQEGVNISTDEQQGFNKPTNEQQPPNNLSNNLPNNLFNVNTNNLSNNNTTNLSNNNTNNLSNVNTNTPLLTLSYKLTPLLDIHNGYNTSLLLTPILTILCKRCKYNLLNNIPLNSMLILSSNSIAIEECYSVIISNISVLYKWCVSSDRRLRSIGWKGIEGVIARGNMLEGVSRDILVGDNSVSVRSEGVNNSSVRLEGVSNSSVILEGASDRSVRLKGVSNSSVRSEGVNNSSVRLEGVSNSSVILEGVSNSSVRLESVSNSSVRLESVSNSSVRLEGVTNNSVRLESVSNSSVRLESVSNSSVRLEGVTNNSVRLGLEGVNNSNARLEGDSNSSVSLGLEGVNNSNARLAGVIIWLVSVTLRSDSEIKREAIEVLYRYISSNGGSNRVISNSNTMSDTISTSNTISNTNTISNVINTSNNTTISISINTLFLSALYVLRNDTHLRVRKRVNELLFTCLDNINTFIKNNMLYVFKCLELLDCKGECAEGCVSEVVDKYEDIIWDIISSSEEGVWGYRDKGNKDMLEGVNCTTSKQQGVNNLTQEQQGANISTIKQQGVNISTIKQHPLNTHLSCDLLIMIIGVLLKRNRKVYEITGYCLKSTNITLIKGLYNIKECKERVLEIIYKIYSEMVGSDSIEDSTDSSDSYKGVSIEGSDKGVSNSRDNYKGVSNTIDDYKGVSIEGSHQGFINSTDNYKGVSNSNMEQHPLITTTNEQHPLITTTNEQHPFNNNNYYYLFVKDILCYKGVSKELYNKYNNKGLLKYIENDSNKGTSNEGVISVSSNEGAIMQSSNEGVTDTSNEGVKDTSNEGVTDTSNEGVILQSSNTPLSYTLEHIQCLMYKVLEQGNREECLDTLEMYCNNNTNNTLLNTIIKECKRIYREDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA6</accession>
    <name>A0A4V2JYA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0077p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13066" checksum="A2A1D118FEE63A6E" modified="2019-07-31" version="1">MKIALNKQKNKNTETFDSLLKITDEIKKRNVSFVSKIKSDLNKIYEEKNAETISLYQSKEEELKKIIKKMKKDVELVLKERKDSLKLLKRKVIEINEKLAEEENKEEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA7</accession>
    <name>A0A4V2JYA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0074p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000074">
        <property type="protein sequence ID" value="TBU20413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0074p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="32167" checksum="BB78B722B7F41710" modified="2019-07-31" version="1">MNTMRAEYQSLETPSIASGEKMKTGIKWYKTWYFATKKFLLDFLSFREVVAIDLIIVCFFEIIFLRTIRIGRLFFVTVAHLFLKSFLEESSHYFYGNIMSGNKDFAYLRILIRVSYFVISIIDFLLKDVLENFYVTNNYFIAFVIYSLWSIFSFFSLLFLVRLYPFCVICEGAPKKEFTFLTLPFFVFIEVSYEISALLAHICSNFEFMHALPSYLVVSVFSCILGIFAAELNDHFIIFCSFMVYTCMNWQFLFNLLKFIWYSFGSHQINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN9</accession>
    <name>A0A4V6MVN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0285p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000285">
        <property type="protein sequence ID" value="TBU17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0285p0020"/>
    <dbReference type="OrthoDB" id="10692702at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1027" mass="124960" checksum="D3FD7681BBB5317E" modified="2019-07-31" version="1">MEEDSSYTITKKYFSKKNYELDIKILTETKYPEYLVPIAYLNIKNNSILHSVPIENFLNNEGVRKRYSTFILIYLRIKPVFYKKESVTFILEYYKENEVDEFFKENIVDFTLNYLQLTNIYDFIFLWKKIDEKEKYLKILLGKYRVDYILEFLLRNICKKTDIKKFKRYFISRNIFEEKFKKNVIYVLSKTIKLLKTSDINCKIKIINENEFPEYFEKIICVNLTIFNFKEYGIRRSNTKLEYKDLENYELSKWDTLDIRDIISFFKKKCYNEEEWQVYFNRESVYKKGFDDFYVHFKLFKTYDLDFYFSKNDLKNVLQEFNFTIKEVLELAKKNSSVKNELKKITENLLNERCKEDLTEELSVMGKSNFIMLFNKYFKVKPIDFLNVYLSEIENEELDFSLFEKEILDEFNRNKDKMKCKELYFEYFTYFNEKYLKLIDKNFIFINPIILKRINYETLVSFYGNLGSIFDKLIENREHFKNYDEYPEIIAYFVEKDEDTLKVPSKKEKVDLKKENVSCKESYINDLLFELKPLEKMLSTFYLPKDLKTKLYFPRFWSVYLRKNRIESLDSLFRKKRGISSIIHLISVSTALFIQDSTSHDTIINYISSIKARSDDLSFYILLFLLYILKNVDISKNYKNRIMNLFEIYFDLSKTDECYFIIKLILDTCFIEEEYKIKFQFKILNLNENKNFKEFYEKNFNLTEFMFDNFESYTSTEKIDIYEAVRILDVNLQKYQENIVSGNLILNKLYLNCVEDPETFLKAFIFLKEIPSYDWSFLENLFTKSENNLQILSKFLSKITKRSNSTEYLTKLLLNYEEIFFKEKNLINFLSEEQKLKIAKETKKLDFFKNLTNFNPFPLLEDQDKFDESTSFDYKKYKENHFLILNEFIKLSMFDILENQNIFYYRDIFYCCFKEYNLTKNSQIFISKIRKIEFCISNIKFLFNKKKMLDFLNQPIEYKDLQNKVILNSLITEYEFTKKKFYKYIILVILGYDRVNGGYFVPLIIKKLDLENILSRCDFLVKYKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTI0</accession>
    <name>A0A4Q9KTI0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1913p0010</name>
        <name evidence="5" type="ORF">CWI38_0594p0050</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001913">
        <property type="protein sequence ID" value="TBT98087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000594">
        <property type="protein sequence ID" value="TBU12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTI0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KTI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1913p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0594p0050"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Cleavage and polyadenylation specificity factor 2 C-terminal" evidence="2">
        <location>
            <begin position="608"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT98087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="678" mass="78810" checksum="7CDEAE5E2B66656C" modified="2019-07-31" version="1">MVECFINFNELVDTRTGIYAHLLEIDSQKILINCGTKTDLDSSWVDEYKDLIPSLDIIILSHLEIAYTGALPKIINSGFYGRVYSTTPIQVLGKYVFKEQNFSNSTFSTSTNQYLETDIDMAFDGIISLKYMQPVEIGSDLYISAYNSGHSIGGSIWKICKDNDTILVCIGVNHRKENHLNGLDISIQNPFLCILDTKYALKPVLNRKERNYYFFGILENAIINNKKVFIPVKYSRMPEIAFLLNEYFETKNEKPEMILYSRYATRYVEMLKTMMEWSCESNQNNFVFENIKIFSKFSLIPEQTDIYIIITENFHDGNFLLFMKLLCENDDNLLVFVDNDISVPGENLGDNILYGIKKNKKFQEKTIQLNLPTFVSLNEEELQEHIASSIKYKTEEEKSIESEEDVWEDEALPDTLRKVAWHEEKTDMWCVSGDEMFPLKMPNKPYDEYGTLVSKTEDKVFEEIKETNDKIKEEIEIIEKIVWEKTALNLNFDKIFIDFEGFSDYKSIKTVLESINPSKLVFINENDEYSNFLYHYCKYNDSFSDVFLQQNKKPINLSSESHISKINLTEDFSKINIKKIGNDFLGGFKGKIIQKDGNYYLEYIGPLENICVGNIQMNVLKRKIVENGFKVEIKGNIMIIENSIKIIKNQNTYTIEGKITNLFIKIRDMFYENIAILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZC8</accession>
    <name>A0A4Q9KZC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor DP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1119p0010</name>
        <name evidence="11" type="ORF">CWI38_0522p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001119">
        <property type="protein sequence ID" value="TBU00076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000522">
        <property type="protein sequence ID" value="TBU13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZC8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KZC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1119p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0522p0020"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU00076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="194" mass="22535" checksum="DC002E0DA913C569" modified="2019-07-31" version="1">MNSSLFSDTFSETKKQGLKHITKSVLNMLESSNGITYTEILRSTSATNSNTLKRRIYDVLSVMRSINIITKTNRRYHISGRDVTTETKMKIEKKKEDVKRMEEMIKAFEFLINKNTGNHTNCEKLYLPFMIVFTDRDSQVQCETNEEKTFFKFKSDKNIQMMDDLAVIKEIQNYTGKSSGKKNTDVNDIFSFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZG0</accession>
    <name>A0A4Q9KZG0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1198p0010</name>
        <name evidence="2" type="ORF">CWI38_0201p0070</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001198">
        <property type="protein sequence ID" value="TBT99840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1198p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0070"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11958" checksum="ACB08A17F6D44970" modified="2019-07-31" version="1">MLTFPGEDTNILLKNGLPIFNLPMPFIGANVTCKIYKVTPFQASARITHIEDQKCYITYRGVFRSLDILANTAEDIYVTDVLKSGQILKALIISYGENNGLILSKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L119</accession>
    <name>A0A4Q9L119_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0931p0010</name>
        <name evidence="5" type="ORF">CWI37_1017p0010</name>
        <name evidence="8" type="ORF">CWI38_0291p0030</name>
        <name evidence="7" type="ORF">CWI38_1145p0010</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001017">
        <property type="protein sequence ID" value="TBU00402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000931">
        <property type="protein sequence ID" value="TBU00675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001145">
        <property type="protein sequence ID" value="TBU11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000291">
        <property type="protein sequence ID" value="TBU17009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L119"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L119"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0931p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1017p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0291p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1145p0010"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU00402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="134" mass="15413" checksum="A6F9FA6DD1E18818" modified="2019-07-31" version="1">MADECIFCMICAKQLNIIYSTDRHVVIADINPLAKGHLLVIPRKHAQYFHELEDQDILPILPLIKMIVKKCGIIKYNILQNNGHIQSVPHVHFHIIPYVNDSECLRITWKVAKVDSDYVQKIIEDSVSKLNAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2G4</accession>
    <name>A0A4Q9L2G4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_0667p0020</name>
        <name evidence="14" type="ORF">CWI38_0376p0020</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="PITJ01000667">
        <property type="protein sequence ID" value="TBU01619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000376">
        <property type="protein sequence ID" value="TBU13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2G4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L2G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0667p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0376p0020"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="184"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU01619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="317" mass="37497" checksum="AC54CA75B3D1B0B3" modified="2019-07-31" version="1">MVRIWIEGCFDLYHPGHVFAFLMAKLLGDYLTAGLRPSDIIEIHKRKPILNDDERYTMLEGCKYIDKTINSRFSVKEMMEDENGKHVNKLFDFVAHGNDPVVCWNGVDCYQVAKERLMYKEFKRLCGFSTTNLIKRIILRNSSILQENDYFAEIDKEILENEECRKFISQIGPQNEENKRVIYISGTFDLFHAGHVSILKYARENNFYVIVGLQKNRFHASQFPTIMSFLERKICLLSCKYIDLIIEEGEVLDPDFFKKYNITYLLRRKNSLCYENINLNEMKLKLLEFSGQFDYLNSKLIQTRIIINKEYYLQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L936</accession>
    <name>A0A4Q9L936_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0162p0030</name>
        <name evidence="4" type="ORF">CWI38_0643p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000162">
        <property type="protein sequence ID" value="TBU04259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000643">
        <property type="protein sequence ID" value="TBU12752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L936"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L936"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0162p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0643p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="109" mass="12583" checksum="0796A848C205CEEF" modified="2019-07-31" version="1">MSREFTTKEKQIYTLLQSKLVLEEAKNTEKFFLDQNETKFSIKSPKIYSVPDTDTFIVFGDLKPIIDLERLRQALSKLGIDQKIIDDTFDKVKSGDMDLDSLKNNDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBH6</accession>
    <name>A0A4Q9LBH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0045p0050</name>
        <name evidence="3" type="ORF">CWI38_0021p0090</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445337" evidence="1">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="437" mass="53720" checksum="7650C26040814893" modified="2019-07-31" version="1">MGGHEFISRIFLSFPLILYFLAEYSEEKMYIAKYRKFFAKKCHKIYKRETKEFVSLPSAIDFAHLIFSQETTKFAIESISNYLQCGISTKYEFRIYNPYETLDRQLYENIFRTFQLNRIKNEWWSILFYSEINALNLDILRKNHIIVRKEFLKYLLKCFFRIYTAVKKQMKYLNINFTRYSYISINDIMNDVSKEISQEYQNIPLYLFPDQYEAICIKIFSQNAISNAKIDKENLINRFNRLFHEYFSRVFYGVYINFIIDISKSELHEGSNLINTIHQTIINNYRLVFDDTQNFENDRMNDLRSERAFLFENSYQVLKFYYFYTTKDTKHSDYKFYILFRRNAKKFEFNYRWYNDFDYQDRIAHPLFYMEVLCPMDLYLIEFVEDECKKSFKIHKIRSPTYKLQAYNNYKFVYRKEIITINCLLDRLIFYQNQNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCI8</accession>
    <name>A0A4Q9LCI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0002p0030</name>
        <name evidence="5" type="ORF">CWI38_0036p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000002">
        <property type="protein sequence ID" value="TBU05547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000036">
        <property type="protein sequence ID" value="TBU20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCI8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0002p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0036p0020"/>
    <dbReference type="OrthoDB" id="2195884at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031494">
        <property type="entry name" value="Beta_lactamase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17030">
        <property type="entry name" value="Beta_lactamase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="307"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="634" mass="74820" checksum="2AD9EE0E61AE15F2" modified="2019-07-31" version="1">MPLINVLKAKYSSSFLIETEETSFLFDIPADIYGCNHSFLDLNNKTKKDIKFILPNVDFENIDSIFISNSRSLGVFFIDKTFKGNIYITDPVYEQLLLRLEELQSYCITYQESDSDLENMEPTGNLDFKENMETTQENNFDKSRILLEIKKSEKKVKKFKNKKFKLVSIREANVSFFKKRVVKIKFNQRIFLDGICIESLSSNTYIGWTNYSMKYLRGCEEKTANSIIYVSSISYNKRFSFDSPKFTGDVIFLNQNDFKTENLFFKPKNTKTEKEIFLGIEIFTQHILNFLDTKKIVILPSEMTTLFLEIIFHIFSILQKKGKNVPVYVISPIFEKFNTVVNIQSEWLNDIFQKTSYLGNEPFPFKHFKPFNVINNFSNLRNLEEPSLVFCSSNELNFLKNNFTIENYIICNVNNAINSDYWIDENFTENLIATDFCKKTGNPEELDSKLEVNKTIPQSYVIPGLNIDLKDCVVQKKKEIKKRENSVVDNSKRIKKVKKDKIKNYEIKLEATLEEIREKNKESKIFCTTVYKNMIYLDTRNSYFVEDFCNFYDLEIEGTTDIYFKDGFAFIDGILTNNDFETQENIKIKIRNTKNFLKQLFLTEKYFVINDWYIFPEKKFKIKLNFDKIFLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH88</accession>
    <name>A0A4Q9LH88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2447p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002447">
        <property type="protein sequence ID" value="TBU07136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2447p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19279" checksum="85EE1E5005D6149B" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPQPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMVLRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI69</accession>
    <name>A0A4Q9LI69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2341p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002341">
        <property type="protein sequence ID" value="TBU07858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2341p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="63" mass="7458" checksum="9B43A18A9F3757C9" modified="2019-07-31" version="1">MAASIGLIGKKSYYEEDAIHKKYFSSYELKKYLENTDLNIKSLVMKIKYISRIKYLIKSILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKG5</accession>
    <name>A0A4Q9LKG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2223p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002223">
        <property type="protein sequence ID" value="TBU08753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2223p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="29941" checksum="DFCE1FC2CEDD3115" modified="2019-07-31" version="1">MKKQFVKEMEVQLAKLYNEIEKRKLHSKLYNVRQNELVSFSGSLRWIKKGNIRLREEDQHCNKSAKNLDYLTTRFEEILRYDCLKLHNELIKLETRIKTYGNIQNIRLDIFIWNKRLNGITLVEVGITSQDCFKTYNTLENELNLIYKCSSIVLKKTFEIIYFDRRRGLESGLNTEESCKSASMGVIKRAEMHGELKPLLKAGKNEEGGVKTENTKNILHSIISDGAITVKESAINIMEESDLIENKYVVKMIENNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPF6</accession>
    <name>A0A4Q9LPF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2044p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002044">
        <property type="protein sequence ID" value="TBU10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPF6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2044p0010"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="103" mass="11992" checksum="7D27594BEDB138C7" modified="2019-07-31" version="1">MRVPTDNKIIIKNHLLKKGCLVVEDNIRAIHPELNIPNFHVMQMMRSFVSKGYVSKVFVWRHGYYFLKVEGAAELKKEMAYEEQDVPVPHGGEKQEQIRARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPQ3</accession>
    <name>A0A4Q9LPQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1775p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001775">
        <property type="protein sequence ID" value="TBU10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1775p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020718222" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7920" checksum="D60C9FD64CEB1665" modified="2019-07-31" version="1" fragment="single">MFLSNLNLILFTFIVYNRYNCTTSNIQQSEDTREDLKQYFKDFIEKNDHSVKINEEYTNNNFIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ39</accession>
    <name>A0A4Q9LQ39_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 10-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1687p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001687">
        <property type="protein sequence ID" value="TBU10548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ39"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1687p0030"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="43694" checksum="23685DB9D6033C31" modified="2019-07-31" version="1">MNCSNLKIIQSFEFPEACIAMKMTEDKTHIITCGSYKPQLRIYDLNELNLKVERHMESEGKKIEILEEDYGKIAILRNDRYIEFHAKYGLHHLVRIPKLGNDLSFNKISAELLICGDSSDIYRFNLEQGRFLKSLISECDNINSIKTNPVHNLICGVGNKITFFDPRSRNCLKNFVSENVEEYSSISFNNNGINFCVGTEDGNIIVYDLRSKKELFIKKHQNENKIKEILYSDKNIYSLDQKTLNVWNLNQDLVKIETGFVQNTFIVDDGFVSIGGDTPEIHCYYSSILGKSPTWCTQMDTLDLNSKNINLDNFVIITKKEMQDYNLQSYLEKGKIFQHLNRYMIDSNLYNSLTNKNTKIETRKTKEIKKNYKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH1</accession>
    <name>A0A4Q9LQH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1552p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001552">
        <property type="protein sequence ID" value="TBU10783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1552p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="20147" checksum="E5E6B79DD8F130D4" modified="2019-07-31" version="1">MLLAIDINEYRLHIGEPPECIEGGNNNGLKYLAETPKQIVSNDDRESIIAKTLEGHYIFAIASNFSNKLQRVNSVVLQYLKTCLAFAKKKERVTLEPELEVDNEDKNFVFLDEKYFGGRINNKYGMNIIRFMRESKIERNSNYPLRRFMKVDNGMECESYLYIDDARIHPIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR4</accession>
    <name>A0A4Q9LQR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1784p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001784">
        <property type="protein sequence ID" value="TBU10406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1784p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13314" checksum="BB95762A693BEB24" modified="2019-07-31" version="1">MALMNDFLTNFIYTCSDFRLLDESDTYFDDHHMICQDMKPYENNECIIPSVCEEFKKCVRCCEPEFQKCFRYCEPEVQKCVRYCEPEVKKCIHYCEPEVKKCIQYLEPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR13</accession>
    <name>A0A4Q9LR13_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1711p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001711">
        <property type="protein sequence ID" value="TBU10506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR13"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1711p0010"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="9">
        <location>
            <begin position="509"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="405"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="697"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="802"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1244" mass="147004" checksum="87658021053DA614" modified="2019-07-31" version="1">MLEKIEVENFKSYNGKCIIGPFTKYTCIVGPNGSGKSNIIDAICFVLCIPIKNLRVSKLSQLINGVNTYMSVTLYINTENELRLKRKIVLREREGKDEKEDSCVVSSYFVNDISKSYSEYLEVLSSLNFFPKIKNFLIFQNDIGCLSLKSSKEILESVEEICGSIEYKPKYEELSKKFNEITLSLGRISDMKKKTLNFIKETKHEQQQQNKIKNLLSLKESRSILLVLANLKIQENSMMNIKEKISELNFEKNILNEKNESKMLEEQKFKTFGLQKEMLKMEEFKNINLEKIKNITKFYEELCGSEILKEKNENEIYAKKSKIKFYLHEKYKEVEKCKNELVYIEESFKKVMENNEEKRKKKEFYIEKYGDIFNECEDLFLQKCRNNLREFKEEEMEIYSLKDQIKKFKIKLEIINKEISKFDKEKDFLGFEENLEEKLNLLKKNKENIFLKIKTDLKKVEELENKEIEFNNQLNILMKKIMDLKVFKIEGDKRTKMRLFVKTLQQINSSVYGEFNNFIEVSQKKYEKGIGLLMKGNEYSVVVENDEVAIDCVNYVKEYNKKYFGTKVGRITFLPLKEIKGRHVKGEFRNLSGAVPAIDTLIYDSKYKNVVEYVFEDGIIAENLELAKDLVYEKKIKTRVVTHDGVLFNLNGTITGSSSKSFFEEKDNSISELLFERNKILDSLKTIYDSKQNLSHIEIFREKINNFDLKIEETEKLILEKNEKRKLETEKINKLNENKKELESLIQEKENSLNLLEHKIEKNQKRIKKYENKIFIPFLEKSKITVEEFRNLQEDLNDFYLKSDYKNKRKEIEIKLDLIKDEINKFQSKLNELENESMFKFIIPQSIIDSVDINQEMEIKTVINILETFISKYQIENINYTTEIQKLKEKFLIEKNKFEFMNKKITDFLEKNKFNRIRKRLENLRMALLDEINIPILEGNLNEYKKDLIVDYSILENELQNSNLKSTQNFDNENFGNINENKIENNKENYENETISTKEIINDTSKYNILKNMLSDELKEITKQLDLFIPLVKNNNSNLESNLSDLNEEHSKIKFEWQKTKEDLKNIKNQRQEIFMNCFNKINNSITRIYKELTKSESEGSAYLILENTDDPFKEGIKYHVMPPRKRFREIKDLSGGEQSIASLALLFAIREYKPSLFYIFDEIDAPLDKFNVFKLSQYFENFPTQKIIVTHKINLFQFSESLIGVYKNKEGVSKTLSYSNKGVLNFSSLIGYTSSSKGVLNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR15</accession>
    <name>A0A4Q9LR15_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1607p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001607">
        <property type="protein sequence ID" value="TBU10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR15"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1607p0010"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="6">
        <location>
            <begin position="225"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="848" mass="100303" checksum="D0E001DA2A79EAC1" modified="2019-07-31" version="1">MGPGLIYISDYQENMHGEISVENINFINFLENTEFPFLTYSYISVKIIRNEIIEFCMKIIYNKEIKNYFGFVKGTNLRENKSYEDFKNNYNQISQFKNEFTSVEMYKNFEQMKLKIKEILISEKVDICIFHNLHENIYKNYISDEIIICDLFVVAPDFIKGRDYSLEEICKTLDIKLPNKNYKKSLEIESFFELERNCGIIIESFKILNILDLYKQMTEISGNLLSRTFQNQRAERIEYFLLHEFYEKEWIFPKKNKLFLNENEKSIFFDSNQENDRNKEEDKGYKGGLVLNPNRGFYETLVLLLDFNSLYPSIIQEFNVCFSTVGIFKFNEKNIENDLEICNNSLNKEVGILPKVLKRLTERRKVVKELILNSKNKNEKKNLNIRQKALKLTANSIYGCLGFVNSRFYNLKMASFITFKGREILTQTKSIAENKFKLNVIYGDTDSLMIDTNLSGINSNYNKSIEICNQLVKSINILYKNIEFEIERVFKKLILYTKKKYACLCIDSKGNSFIETKGLDMVRRDFSKSTFIISTEILNILLMDMEVKENYKLVVGTELENMTENIFFKNNENKKIAELILEKLVDFKDTFEQQSVENFIINAAFSKNPENYPSTVFPHVSLALRLKENGIIYKKDDVISYVIGIGDKNTHVSKRAYLPNERYKIDFNYYIEHQVLPSLFRLLSLYKGIHHENINKIFGVIKPIKYLPTKNITFITKCCETVQEASKNCKSCNKEIHINFYINKITEILRKEISNLYLTDYKCTECNLKYDTYTTVCYNCNFVNKYQPKNYEFDQFLYSVYVTFKELEMNEVSNLVLKCLNFSEYRKIDLEKYFGKEFMNYCENKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR76</accession>
    <name>A0A4Q9LR76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5101 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1424p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001424">
        <property type="protein sequence ID" value="TBU11029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1424p0030"/>
    <dbReference type="OrthoDB" id="2186985at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031492">
        <property type="entry name" value="DUF5101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17031">
        <property type="entry name" value="DUF5101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12510" checksum="E1B19E4CD7B72405" modified="2019-07-31" version="1">MKFVLKDKTNSKENAEMNLKKKEVKNEEKQKVLNVMINVYETTRDYSFKYDLGKCIEIIEGKENQEVCELKVALIDALEENELLFDEKCKLIVENDYLKDILKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE7</accession>
    <name>A0A4Q9LRE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1625p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001625">
        <property type="protein sequence ID" value="TBU10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1625p0010"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="12787" checksum="13ED96A93629FD79" modified="2019-07-31" version="1" fragment="single">MTLEELKGNLYEIQKDFIEKAKCVIENNEIGIFSSPTGTGKTISLLLSVYNYFIPPKEESNKYTYFGLNSENKKLMEQLFGQSDRITKVFYCSRTHTQLNQAINELKRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ9</accession>
    <name>A0A4Q9LRJ9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0405p0020</name>
        <name evidence="7" type="ORF">CWI38_2032p0030</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002032">
        <property type="protein sequence ID" value="TBU10090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000405">
        <property type="protein sequence ID" value="TBU13522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0405p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2032p0030"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="28935" checksum="16570E79FE633798" modified="2019-07-31" version="1">MPPKLPPKSVKEQKKELEEKMFGQKNKKKNLQLKKQMEKLKTLETVSKKKDDKKDERKETVQKVPVGVDPKTVPCKLFLQGNCKKTNCKFNHDISLEPKNEDQQVKLVCRFMLDAMNSGQYNSQWICPDKTCSDVHKLIDVDKENAEITLEEFLELSRQEIQENEKLTEETFMEWKKKKIEEQVEFEKKAREIKMKGTELFQFKPEVFKDDESALECDYRERCYSDEEDIIDKIAEMGIKNSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP4</accession>
    <name>A0A4Q9LRP4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1943p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PITK01001943">
        <property type="protein sequence ID" value="TBU10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1943p0010"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="50572" checksum="2B5FDFE902C76EF8" modified="2019-07-31" version="1">MNLQQKLQNRIKGAKFRIINEIMTKNKKIKLKNTDIKEYHDGYTQQVNKWTYDPIYDIIEYLKQYSNLTIADVGCGQAKISKYFQSNTKKENISEDNNSKKNTREENTREDSNSKDDEDISNEYNNKYNKKDNINNKDKNSINKHNKRDNMRKYNHKILSFDLYPTSKEVIKCDMEDLKLKDKTTDIIIFCLSLMKINIYKTIKESNRVLKNNGKLIITEVLSRIISVKEFICQVENMGFKILKVRNKNKYFINFIFIKIKDILKENVMEEGVSDSDMLEGVNDTNMLEGVSDSTILEGVLECVNDTNMLEGVLEGVNNKKMLEGVLECVNDTNMLEGVSDSTILEGVLECVNDTNMLEGVLEGVNNKNMLEGVSNSNMLKGVSDKNMLEGVSNSNDNQQGVSNNNHNSNTTSNSNTNYRGYITENEGEILLKPFIYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS03</accession>
    <name>A0A4Q9LS03_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1277p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001277">
        <property type="protein sequence ID" value="TBU11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LS03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1277p0010"/>
    <dbReference type="OrthoDB" id="2194298at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="10">
        <location>
            <begin position="623"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="9">
        <location>
            <begin position="727"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1244"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1304"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1710" mass="187442" checksum="9D5ABF55954A4F83" modified="2019-07-31" version="1" fragment="single">DIGSSSNKGNTRDISNTRDIGSRDSSRDISNTRDISNTRDIGSSSNKGNTRNISNTRDIGSRDSSRDKGNTRDISNTRDIDSSSNKGNTRDISNTRDISNTRDIDSSRDSSSNKGNTSKRDSTKDISNTKNPYTTNNNTKNPYTTTNPYTTTNNTTTNTTTTHTTFSTSRYTLPPTILRPIPLYTGKQVIQILIEDSLAPYSNNSRYSNGGDSEGDSSKRDKSSKRDSNSIYRGNSIYKGDNSSMYKGDSNNSRSNNTISNNSISNNSISNNTISNNSISNNSIHTNTTHPHTNNNTIHTNTIHTNNTTNNTTTLLNIYARNKECIKEEYTYNTYNECIVIFKNNYYLYGQLDKSIIGNENKKNSILYKLMCISNICSVRAMNSISRLCSRYIGEIGFSIGIDDVYPSVILQKKKNEIVKKGYEECRRIIEGVVGEGGIEGKGNKQEGVNNNSGNYKGNNNSTNTLHPINDSTNNYKGDNNSGNYKGNNNSTNTLHPINDSTNNYKGDNINTNNTNNISTNNYKGDNICTNTLHPINDSTNNYKGDNISTNNYKGDNISTNNYKGDNISTNTLHPINDSTNNYKGDNISTNNYKGDNINTNNTNNISTCNTNNNTTTITPTNNTTPTTNNNTFIENNISGILSKIREKCGNICIKELNKKNSPLIMQACGSKGSKINVSQMIACVGQQIISGNRIPNGFYKRSLPHFTPMTLIPQSKGFVSSSFFTGLNPIEFFFHAVSGREGLVDTAVKTAETGYMQRRLMKALEDLSVQYDYSVRNSCNEVVQFVYGDDCIDPCLVEEESSVVDLEKVYREVKGEIIREYSMLGVKGDVLESSVLGVKGDVLESSVLGVEGGVLESSMLGVKGSVLEGGVLGVKGDVLESSVLEGGVLESSVLGVKGGVLESSVLESNRLYDNRLESNRLYDIRLYSNNNNIHNTNTNNIHNTNIITNTTILSKINTFLKGKEGDTIFIKGKHIKVVESNSDSKGNRLDRGSKGKGRGDSDKGNRLDRGSKDSKGDSDKGNDYKGDSKGNRLDRGSKGNRLDRGSKGRGDSDKGNDYKGDSNGYMNNNNTTNTTNTNNNNNTNNNNTITTTFAALFTSRVLNRYYDCIIQPGTAVGALAGQSIGEPGTQMTLKTFHFAGVASMNITLGVPRLKEIINATVNISTPIINTRIKGVVESKGGVSKQEGGEEGKNMLEGVSNKSSMVEGVSNRGREVEGVSNRGSIVEGVSNRGSMVEGVSYKSSKQEGDSNRGREVEGVSNRGSIVEGVSNRGSMVEGVSYKSSKQEGVNDKDSNRKGVSYKSSKQEGDNDKSYTLHPVNNTNTTHHPVNTNHNNPELLARCVKGRLERVCLKDVCTYIKEIYGKYEISIEIGVNLNTIKLLCLDIDMVSIKNRICEELKVGKEYVYIKGGVIVMSIRRGISRRYNSVKVGGGVNDSSGNYGGVNYSTNKQQGVNYTTNKQQGLINSTTNYHPVSSTPYKQHPLTNTPYNNNISDYYFMKDIKRSVRNVVICGLKSVQRVVLHKGENINYTLLVEGNGLLGVLGSIGVDSTKTSSNNIMEIQSVLGIEGARQSIINEVEYTMSKHGMKIDCRHVMLLADTMTYRGEVLGITRFGISKMKCSTLMLASFEQTGDHLFEAALYGNVDSVLGVSESIIMGRGISIGTGATELYYEDRGSDREGATELYYEDRGSDREGMGIIINAFFLDLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS42</accession>
    <name>A0A4Q9LS42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1819p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001819">
        <property type="protein sequence ID" value="TBU10365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS42"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1819p0030"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10796" checksum="32CA7790568E170D" modified="2019-07-31" version="1">MSDEPTRQINMQMKTLQTRMKDTIKSEEERGASLQDLSKRTEHLEQRATVFRQEARTTRRRMWFKNFKYYVIGGLFATVMVIIVLRIIGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS63</accession>
    <name>A0A4Q9LS63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1227p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001227">
        <property type="protein sequence ID" value="TBU11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1227p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13445" checksum="CD1C19BE82DD1232" modified="2019-07-31" version="1">MKFEIQLNFFHTIKDTNNENIYLKCFFYYFSFCDNITKYQNINYIFFSIYEFFSILLSLIMSNIEDSNKNKKMRNFLIDEERKNKDIEEAANLVVKNELKEIEAFLEQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS89</accession>
    <name>A0A4Q9LS89_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1211p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001211">
        <property type="protein sequence ID" value="TBU11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS89"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1211p0010"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="249"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="696" mass="78877" checksum="E2A5F1C3B91F8EF6" modified="2019-07-31" version="1" fragment="single">IKLIPLFVNNPFIHRMRHLRSILLSKLTSFSGTVTRVSQVRPELSVGCFVCKACNATIQDVQQYSYYTLPSTCPNHLCTNRKAFSLETSKCIFLNWQKVTVQEDTHQTPPGTLPRNIEVILRNHLIESVKPGDKATFTGTLTVVPEQPGFIHTTLQPTLSGITDNEKKNKNIKEINYRLSFVGESVEIQNEQKNNFMNSDENKKNESIFNEENFSNSILKNSLNDKNRTNNFTNYELGIISHIKNSPDLYNRMSDSLFPSIHGHSSIKKAILLLLVGGTSKVVSGGRLRGDINILLVGDPGTAKSQFLKQCSTLVSRGVYTSGKGSSAAGLTASVVRDIESGDFTIEPGALMLADTGVCCIDEFDKMNYKDQVSIHEAMEQQTITINKGGINATLNSRTSVLAACNPVHGRYDKKKSLRQNINMSAPIMSRFDLYFVLIDNVNYEADKEIAEYILRNHYEAVKDINSKNFEENEFLEKQSINTTDYEENSKNNKKIFSNFLVKENLFDLESVKLYLKYVRGLEVVMEENVKEILVKKYVKLRMDSLVHSNNYRMTVRVLESLIRLSEALSKLHGDVSVKECYVEEAYRLVMSSVVEVKGEDLIVEKEDGNVFRVKDSDYMRVVSVLVGILKMREGCKKEELVELYLEEIENCIGDEGGFYREKSVVEEVICYLVEKEGVLYEEGGIIFIHPNYDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE7</accession>
    <name>A0A4Q9LSE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1195p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001195">
        <property type="protein sequence ID" value="TBU11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1195p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020990418" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14203" checksum="3ED6B17ADD810B83" modified="2019-07-31" version="1" fragment="single">MQGITKFILMSIAYLIVVTSTGNRNDYFRCYAESSSDSREYNRRCRDYSSSSSSSESNCGFNTLVCRDFRCKPTKATKCFTATECVPAKPAKTLDTEIYHIEGIIESAVRNIDPVLNRAAIAFKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN6</accession>
    <name>A0A4Q9LSN6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Muskelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1576p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001576">
        <property type="protein sequence ID" value="TBU10741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1576p0010"/>
    <dbReference type="OrthoDB" id="2188291at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121289" checksum="2EE098C826CB066C" modified="2019-07-31" version="1" fragment="single">STSDIKGDNDSTSDIKGDNSTSDIKGDNDSTSDIKGDNDSTSDIKGDNSTSDIKGDNSSSNIKGDGIKDSNIKGVNNLSSNLDPLSNSTNKQHPLNNSTDKQQGVNSTSNLDPLNNSTNKQHPLNNTKNTNNTNSYTNPFNIQLQHPLLSTLYSHLNNKKFKEAEYLIKNIKNCKYFKDYINKTGYKIIWYKIPYKEIWPGSRGGHHGVIHKGYLYMYGGWNGTQELCDMWRYRIKGDEEGYDSGGGSCKDIKDYNVNTNKDNSIDNPNPNTNPNMCINNGTTIYNPNTNPNPNPNMCINNTINNTNPNPNPNICINNNNSNTNNNVNTSPWYLLSTNTKTQNGPGRRSCHKMCINPLNDSIYVLGRYLPTEYQRESTWLSSDMYRYDIKSDRWETEGEGDSRQQGDSSSNSRQQGDSSSNNSISRQQGDSSSSNSRQQGDSSSNSSISRQQGDSSSITRQQGDSNSNSRQHPVNNSISISSRQHPVSSNSSSTDSLQGVSNSSSYYSSSNSSNTPLSTRTVNNTPINNSSSNSSNNTPLSTSSNNNTPTYTNTPITTYTTRPDNIYDHQMIFYNKITPSFFIYGGRSMLNDTQGYSGLYLYEIISKKWRCIRNDNEQPEFTPWIRGRVGHSVIYIPKGYSSSISSMNGCDFEDMDKDSSKLITTNTDNNLIITTGTNESNTENNTDNTDINLSNNNTNLSNNTNLSNNNTNNNTGTNLSNNTNNNNTDTNTNNNTYTNNNTTNTNIFSCDNSCLFGNFVEYGEVKRAVKLLLKDYDDSLVIIGGQRGKEIFKSMTFYKIESDSVYDVVDMNFIGGDDRVVVRSVLNGRGEIVCLVSNWVEECMDVYVYRLEDGRWCKCEIEDELYDIYEGGDIMDSRDGLDRDKLEDIDKLGDIDDREYIRGRYGKYNKDKRYVRDKQGRCDKDRNNMCVGGKDKVPKARSAHVFIYDKDTDSYYLYGGNVSTENGDKRVSDMWRMKMKGIEMEKIKVRIVFLIRKYKFMCLLGESIEEALKYLRSEVFECVDHSDNEMVGEFRRLCCEIYKPVRSVSVCEVIEEIGLYFNKSMCMPSENIEDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW6</accession>
    <name>A0A4Q9LSW6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1621p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001621">
        <property type="protein sequence ID" value="TBU10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1621p0020"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="224"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="545" mass="65462" checksum="CE483A49B33A088F" modified="2019-07-31" version="1">MKFYLISKYFYSNLNSSDLEIKHFYKEADNFFSLLDQINFIEKYDKSEIIFKFFDTIRKNPLNSYFINSLDIENEIFIFLFDIYIKIIEKCCQIYFTIRQRVFNFKKLKKYKKYFISEDFICFLFEIDHFESKFRNLNEKNKAKIDNLISFFYRIKIIFSNFDKIFFNFRCLSLKTKLLLIPKPDRDQNLLFDSYVFLQIDRNNIIESTIDAFKNFSPEIFSQKNWFVKYSNEEGSGIGLLYEFFNIFGKCIDESVYFAPFKSLEFISICVSSPEEQNKIEQLYYFTGVIMAKSIFMNSVMSFEFINSFYLHLLQEKFNIEDLKDIDFEYYKNLISLRYIENIDPYLTFDISVKIGQKIISENLIENGSEIKVTKDNLEDYIQKMAEFKMFKGMKVYLDKLKEGFQSLFNHCFYNMFTHSDLKIVIEGEKRININEWKAATRYRGKYYTDHQLIVWFWIFLGKSDEITKRKLLFFTTGLSYLPIGGFKSSKFIDHPFTITSDDRKDLFPKSQTCSNLLILPLYDQEDVLLDKIEHAIEVINYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY3</accession>
    <name>A0A4Q9LSY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1073p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001073">
        <property type="protein sequence ID" value="TBU11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1073p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="35504" checksum="DF3FDF41C614800C" modified="2019-07-31" version="1" fragment="single">MNIEMYIQSIVLKKIFETIFFDRRRGVESKRNAEESLKSSEMEVIEIFEVHEGPIRPLRMCVPRKIGLKFLKKPNPISEGVVTIDKPINDLPMSLHLCVPDRIGNYLFPRVGMGVSNGFSLLLNKIQESKEVDTSCDDENTTHVVYCNVSEYLIEYAIYYESRLEAFFEYSRNFINNSHEESNIIASKKFLEDSLKDYLVKYPIDVALGGKMLSQTPINPKRKMKEINEIIKAISENKELEEFIFVQFAHFYVSFFLQVNTGVLGFPPLSRILGSSKLSEARKENKKSEVYFKSIRNIYSAKKWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT26</accession>
    <name>A0A4Q9LT26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1490p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001490">
        <property type="protein sequence ID" value="TBU10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1490p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="49878" checksum="A7ACD3D0D3253439" modified="2019-07-31" version="1">MENPNTVVIPGGKKYEGDIESPFFAESCSLTDTTLYINSRESQSKLNKLTSAWKESMQRKFLDFRSKSLKKIMREFKLNLSNVTNLSETLVNKNECKTVNEKHRIEINKQKLVTNSPCCADVATLLEGIRFYKYLGIIENSRGIPTIERLRRTKLNARNLFQAIYQNIISLLSYHIGVFRLKLSDFSNLDDAVRDMLVKNKIHIRPGFKELLCLPRTELGRGLHSFEFKIKQIILQLLDCLEKDKNTSIRRAAIYKIENNNKSHLALKLEEDQLVNFYYEIENENYIQRSVRPRVKALFCYIRDRNYSEENSKNLAKICEECLAITIIDNTMNHSVQEILYKEYAELRKYDLLANKLGLIYNFSVEIILYVMDRDSIVTKYHKKYLKRLQIPMNVEAYIQFIESRESASFNVILGAETHKQQYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD5</accession>
    <name>A0A4Q9LTD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol hexakisphosphate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1511p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001511">
        <property type="protein sequence ID" value="TBU10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1511p0010"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="829" mass="99550" checksum="F3F6932CADE2AFD2" modified="2019-07-31" version="1" fragment="single">TKNKEKINDFDLKKNEIQIILKIACQGKYRVVENLLSILKNKKAKLNVDIALYNIYGEEDFKKDIIHKYFKYLLYKDTKYLNEAILRLEKYITLILYEEYLFTMKPVFYNIGFQAWLRSNISYVNLFKYISRKKDKSFIFSPLNLLPNINIEFNFLNILKKNKYYILKEHVPFCCRTTADKINFVPNLSEKYILADKKSVWFNLLEEPCIYIKNKFFIYRDYQKYYKNPTFFRGIDCQEIEKTEFEIKNQLLNELKRESKLIVYKEKTDGIKPYEILDIKYEDILTSIEYISKYKKTENFIYLRFPITSSLPLRFETFDKLFEHVSRFEKDSYFYVQSNGRKGRCVYISLLINLIYNWKYNINIETEDSKFHFKIIQRLVSVLENGIEAKNRIDHYFQIYFQESFIQFFLSIDIEKYKIRAIKRYFVLICFSSYLYNQSCKSFEEFMMNRLEILNMYNELNEITENNFFYDLSGFKDESICHVKKRNAHILGSMMILKYDYFIGSNIFSLPNAIKETQNFRYVVTGDNIICGIAMPTRKAIENVLKKMRSLSKNFENNIYWFCLREEPVIYINDHPYVLRNVEKLSENIETRGISVEIVENIENKLKNEILDELNEGMLLVHKEIIKNGEYITKGVWVKVNSVETTKEIFLKNQCIFKRYPITDERIPIPSIIDNIYKFIREIKESKLLIFNCQMGRGRTTTGMVIAKLVCDKDKIPSEKSRFYPPKYKIIELLLKILPAAQLSKQKLDEVIDFFDHLENLRNVIDDYNNGSDERISKGKRYLSRYFYLICFCNFYYQTDEESFVSYLEKRHEISNLEMEIENIGLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH4</accession>
    <name>A0A4Q9LTH4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1488p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001488">
        <property type="protein sequence ID" value="TBU10895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1488p0010"/>
    <dbReference type="OrthoDB" id="7967311at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45453" checksum="EB773F9718AB8C38" modified="2019-07-31" version="1" fragment="single">MLQLKNSLKKLNSNTPRDDGKLILGDINAKVGNGSHNMWYFGTGSNLNIASINFEMQENSYDYIDHVLIDLRHGSDILDVRTYRGADVDSDNYLVVSDRKLSVDKLSNNQETREGYQVQLEDISCEPKIRLEPWFDEEFKEDLEKRRIALNLPHRKLESKTHLNAKKRKSEKKNSSLETFKSWETVYGTKSQKNVEAVEPTFTEVGDIVLKLNNHKVLEAPRDGDMWTISTDLKGLSISHTRSKTGITIVLIYHEKSTAQFVMAPLNVNKERRSRLLGPLKSLRSQLESGSVSYTIMTIDLVALTKVLQEMLVRIKRNTDVYSYVGSYKKKYGCIFSVNINQSRCSMLVRIKRNTDVYSYVGSYKKKYGCIFSVNINQSRCSMLVRIKRNTDVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR7</accession>
    <name>A0A4Q9LTR7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1441p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PITK01001441">
        <property type="protein sequence ID" value="TBU10995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1441p0010"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="817" mass="96232" checksum="3C00834BF1B797A3" modified="2019-07-31" version="1">MGKKEVLKIRKTNFQNNNLERFGLRQIIGFLSHPNILNNLYLVVLVLLESKYQFFDEMVVKYSILPLYGKYGYLVSKIVNGIIAGLADYLIIKLGTIYKADEDTLIYVTALSHGLWLYSPRSHINSFELFMAVLCLYALETFKTPTISLLCLCFIFYLRSSILFLSGVHIFFAVFQKNYSSIEDDKMRKNKKNLPECNNLQQEKLECNETNNNDCNQSKDRTENVNPVTCSKLHSIVNYLKLVKVCCIWLYIIRMIKNKFVEAFFKIRNIFCSKTDSKIDENLKKSANEKNIDFNNYKECFYSEKDNEQLKLADNQVNYKQDNKYNHYEENISYNDAKECYKPEDKSNDYKTKESIKDTKNKDIYKSDDTHGQSKIKGHIDTEVSVINFKINDFEDAEDLDLYNRYGRRVLSNIMVFIKNIPCCLLLVLLMALVDSYFYKELTFVPFVFFNVNVRWSVSEVFGEQHVLSYVWFFIVLTGFTGTFLFLNFNANQNIAISVLIYLIFYSALKHKEMRFIVPVIPFCNLLCAIGINKMSYRNTGGINYIRKKLYSGVLYVGLYITFFIGLYIGLVHQNTFDISFFMKTEVEKILTESFFAANTDLDFYKNKNIKNSERHKIEISVDFQNVLGKDISVVQNTKNIEILYFVCPYSLPVYSFICYENVNIKSVSRNPDITVKMKDLVVCKRFDGQKIIFFEYEMYMDLLEATSESYKTQLESKKDKNNKIDNDKIVDEKVEKEMRNNNNRDDTDNAFIDKSINNSFEGYDYILIYKHIFEKYSNVFYEYEIINTFKYIHVLFEEEKRIYMLVLKSKKYNNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU13</accession>
    <name>A0A4Q9LU13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0887p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000887">
        <property type="protein sequence ID" value="TBU12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0887p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020633764" evidence="1">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="128" mass="15256" checksum="79E6C7CAA5664F13" modified="2019-07-31" version="1">MKNNAKKFFLMILIFFNTNIISTNEHETIVNEIRCVKEKLYEINEIIAYKSRNVNNRKYFFSLDRQKSTKRRYCAQANITTDYSFTSVVSTQDIKEFSSMVKDLKEYLKTNPYKNFILTNQIFSAKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP6</accession>
    <name>A0A4Q9LUP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0960p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000960">
        <property type="protein sequence ID" value="TBU11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0960p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="30907" checksum="13277D1C2C21EFAC" modified="2019-07-31" version="1">MSESKRKRKEIKGIGKKNFDFPGKIMVHIFLYIFFIYFAILICSVVALYFDIIGKRSLKIYIAKYTLLASILNISLILNGKKRIDRLSEYISGSIIFVFIFFTFISEMYINTFKFKGGLASKIVLAVMKVFFKSAYSFYTSFYIAFVILSVFFKSVFWLYISFYFNDCKFIRKRTHWCNILRYLLYIYILIIRETVCQKVFKSKMKLFLFSKLVCYIIVIPISYIFMARKNDFLLGSLLFIYYLFLLISIDFNTMIAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ4</accession>
    <name>A0A4Q9LUQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0956p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000956">
        <property type="protein sequence ID" value="TBU11976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0956p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="463" mass="53112" checksum="84DF2EF5D872936E" modified="2019-07-31" version="1">MGKIKLKVYKHLFSLNTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLIARNAKKIFSAIEQHAISITNYHIGVLRLELANFSKLDDPNKIHLRPGCKELGKGLHSVTLQSEHMLLQLLDCLEKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLCNEIEKRKLPSKLYYARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGQTVDHLATRCEKMLGHDYTRRHNESHSVQEILDNEYAEIRVDTRIKTDITLIEVGITSQDSLQIVKTEKLRKYDLLANELGLIYRCSVEIIPYVKTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPIPHLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPNNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW2</accession>
    <name>A0A4Q9LUW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0781p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000781">
        <property type="protein sequence ID" value="TBU12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0781p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="31418" checksum="D3E78FFA1E938F3E" modified="2019-07-31" version="1">MLKKERYTPEDYMYLEMKILNPIYYVSKGNTLTFTVAYVLLFFIFYTLFLLYYIGIVWFFIVKFECEEVYTVLKKYFVLVNLFTPHIVHHIMFMYKDHDITFLKLSIYNISILLCILSEICIYKHNSLNQEKILPIIIVFIYQIIRLILSFKYFGDFIFFIFKFEQQTVRNTFIFFLKFIMFFIIDAFFKPFLFNSFSEIFFLQSIFLVFKILYVAIFIRKTKYILNCIFGVIFYILLNFIFEWNILQLIFDKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ7</accession>
    <name>A0A4Q9LUZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1125p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001125">
        <property type="protein sequence ID" value="TBU11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1125p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="28752" checksum="30523E6454EB3067" modified="2019-07-31" version="1">MRYEYGNIIINLIIYGFKVNTKKAARIIQEDSKPFEIQCTCISEEDAEKEKKRIAEEENKKKGESKEDEEAGVKEGSKEGGKEEDNEAIDDATVGEKDAAMSNKEGTSEGANCTKNKENKADKPKDKDEDTNKDKKDEESKNKFLKITKTYGGSSKDSVVSLSNFINAVQNLKFKENCSITSKGWFKITLLGSKPYSLEVQPFKNISPKNIQIKDTIKIEFSQFGKLSIKISNKDSFNETVESKIGKEIFEVINGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV79</accession>
    <name>A0A4Q9LV79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0703p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000703">
        <property type="protein sequence ID" value="TBU12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0703p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021028640" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="36762" checksum="16DEED958DA50624" modified="2019-07-31" version="1">MFYLLFLYVVRIWMWCAVRENIIEEISKIFSFNKSDNIETFSENNTKADISEVVQNSVIDKSDNIETFSENNSKADISEVFQNSVIEESIQSQTHNEEVEAETSENLLTKEKEREFNDKCRVFFENIVKSILKEVNSCFFEENNEADIQGDVLLKVFKTIYCSKNNLDAKKDDNCTNSETLECPHQKQKKNKQRNELSERRRAKISGKRRSKCSNFWKSKYKDLKSKNRKVKIVKVFLKDEGIQCDINDPPQNPSFIPPPPPLDNLRNFENKRSESSNVQKELPKKNASGSFNPDLNSALLKKFEELRSKGRLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB6</accession>
    <name>A0A4Q9LVB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein phosphatase 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0723p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000723">
        <property type="protein sequence ID" value="TBU12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0723p0020"/>
    <dbReference type="OrthoDB" id="2195607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="645" mass="76512" checksum="6B7C07B254A430A8" modified="2019-07-31" version="1">MKSNLPASNKKKYRKVNEQRKRFNCRKIENGLKVIEKIFTSPELNNEEVKKETKGSKNEICKKKKETRCGFSYINNENNNCGKIESNLKNYNHNDEENEFGISQKRNEANKYCEEQENKSKYSIPVNQLISKNYYFIEDENKKEHSISVDHFIDNNENIKKEGENQMEQIIEIRKLIKENTNSNEYNKEEESIMVGNFMNKKNFAKQTNQSIENSKNMMRSKSPFKFKKHISSDEMYIVEILKSQNTQQILPILTNIILNVNLSKDLETKILNFLKDKLSKISNNITIPFLFDHQSKDDRFIVFDEWPVFYNSILILKKYLTRNFFSKEIFFQIFTENVISNIFERIVSRDVKERTVVFLLSELIVNRIPEYTKIYLKCLINEIIKIIHSKTATVGIQEILKFSIFSLQNFTDLNIDIFLFECILPLFKKNINQSNGIEFIEILKIFISKKSETIKIILSYIIRSLDSLSGYCKELIVKFLEIIIEYNGNILIENDLLNHFCIILCHSIESSYYSLVESVCNLFLNEKCYLFLKNNSNFILTKIFDSIYNLSKKYWNKKDICQVLNVINLLMVMNRECFENCLRNYNLKKYQEKYPSKFLKENIVLECFKNGLLRNNSETINNVRKKSTVQLNEDVLKNLKRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ4</accession>
    <name>A0A4Q9LVQ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0997p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000997">
        <property type="protein sequence ID" value="TBU11881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0997p0030"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11987" checksum="EA8C1B87D31B475D" modified="2019-07-31" version="1">MLYHKIVDLTNTTKNICLSFIVIKEISVTTTKDKDIVRTYLISDETGSIEYSAWNIQFEDGDLINITGGYTSLFKGKTRLFNSKNSLINRSGKIRKVFSLEPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ5</accession>
    <name>A0A4Q9LVQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0749p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000749">
        <property type="protein sequence ID" value="TBU12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0749p0020"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38361" checksum="653F581B9229456D" modified="2019-07-31" version="1">MIEEIDIENTNSSDFQSYIPKETTKNLEVDDSAYTLLEYISLDWPAQSFDFISDYKLVTGTNPINDNPKLITLDFKKCDFDKNPNLNKNLKIKEHQTNYSFNKIRYNLYTEYVQCISDNNLCFYNSNIKLIKDIYIEQGISYGLTNTDSFTVIGSKCGELLFYNDLFQNITNIKLHNGSVESIVCTDGCIYSGSTDKKVISYDFKSNKPIFELNFDSEINALDFSANTLCVGDDSGIIRLIDIRNTRNIESITWHNTPISSISYVEKDVFISASDEQVALWDTSFEEEWEYHKYIYFVHQGNTFYKDVRVCRGNSNIIFTTALEGITLFSPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW16</accession>
    <name>A0A4Q9LW16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0613p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000613">
        <property type="protein sequence ID" value="TBU12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0613p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020412524" evidence="1">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="25034" checksum="FB72411492F7B333" modified="2019-07-31" version="1">MLLRQKNTFLFYIFIVVCLSSRILSNHYNINEFRDFFVKKSLDLYYKKTKGLASLPRAVDYTFLFCYDSQIEAFANVLSNNLQGKPSNNYEININIPNSKSTRNNERIKLKLFSINRKINDIWSKSSINSKNNYQRRIQRKVHIFAFKNNFKIILDKIFRMHKCIGVITCRFNNFNNHFVSIEDTGKGISKKITKRYLSDSIDILLNSKNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW72</accession>
    <name>A0A4Q9LW72_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component Sec6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0722p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000722">
        <property type="protein sequence ID" value="TBU12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0722p0010"/>
    <dbReference type="OrthoDB" id="2190236at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="32944" checksum="B0DEACE71C2C7DAE" modified="2019-07-31" version="1" fragment="single">MLHSEDEQEREFLFELESINKIGIEIEKDLKKIESYIKETPLSTLEAFKTYIEPKRNLDKIIYFYDLFLKSAENIYKQQEKIEIIKNKEIVKEEFDKEIKIIKCLEKIKGELFNFKKYQDIHAVKKFCDEVNKNVNVNLEMLEKSFFKYIGHQFPNMNYKTKICNLSNFLYLNREKSIFVKKYVDLFIIKYGSRKIENKYIELVNRVICLHEWIEEVKKVNDFLFEEDITGSINKEILEKLMLELKVVISHALMDIDRKNKPENLIYLIKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL4</accession>
    <name>A0A4Q9LWL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0522p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000522">
        <property type="protein sequence ID" value="TBU13128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0522p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27596" checksum="6F675C079BC7E797" modified="2019-07-31" version="1">MTMNENGNLLEINNQLKNINKDNETYGKLIKVKEKILKCYLMHLIVGLEDRELVTDEIFKLNAILQKICILEKKAEKIESEKCEESRENIENKKRICSQEIIKNKSVNSKREKKRKNPKIKSKINAEALFKKTKIEVDKNIDTVQFEIISYVMTWNSILRKYSKRYIKRAQIPMNLEAYIHSIRLKNRDQMPKRAPTCLITRAEMHEEPTRPFKQANREEDAETMVVKEVGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM5</accession>
    <name>A0A4Q9LWM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0513p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="17151" checksum="2280308C5A68B04D" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISFKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX11</accession>
    <name>A0A4Q9LX11_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0471p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000471">
        <property type="protein sequence ID" value="TBU13313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0471p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020383917" evidence="1">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="381" mass="45128" checksum="BCA37377C5D1DBD7" modified="2019-07-31" version="1">MQINFFLLTSLLLFNHVSNCRNSIFLNKFMTTGMLKPYFYITFYFKSSVLTSNPSTAVENMCEDDSFFIKNYIKSAISFYFSYYYFYCCDDETLEEKRRKMVKEKYIEKLNSLNDINEQKKEDLLLNFELDWSQESIKNHDNCFYDGMDYALTKLILHIQKKLNYNRLLYFSVVTLLINQDEFLNVIKSNLSLAKTHVQTLEGEKNQYMTQGIEKHNSQAVESNGDLTCEELKKKFLTSFPNYDLNMYKKIYYVDEDSPIPLLNRSKDIIKEFVLNEITCDDRKMVECIAEFRFKENGLIPSRTRFSLLGYYSGLRLISSEYSGALYRILEKPISENILCWCQLFISGMVFHDISSDLLRYSVYKYCNEMEKKQGKSFKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX21</accession>
    <name>A0A4Q9LX21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0601p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000601">
        <property type="protein sequence ID" value="TBU12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX21"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0601p0050"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="194"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="359" mass="42018" checksum="3A061A4A9C4D3941" modified="2019-07-31" version="1" fragment="single">MDEVWIKIGNITSLTVEQLQKMFLWMYAEGKKPSFVTSLNKQKLKSTNLFFIDEKIEIKIIKKKFKLRNTAYMQEKFDINTLIRTLFRKIERNAKPDLSLITETEVEKFCIKNISKIYVEDSTFVKNSESVEDISTVENLSKNKNLLKQNEIKNEYKIDNKILILKDESENLKFKEYLLLNKEFTIFTDYINNFIVSIDCEMVKTSYGKEVGRVSILDNQCNVIYDKIIKPEAEIMDYLTEYSGLDKDSFEHAVSFLEMKNDLKKIIGKNTIILGHSLFNDLNVLKIYHDSLIDTSHLYKTKDNYKTSLKNLSKKYLNKEIQSKSHCSIEDAKVCLELLALKINEMKDLVENDSANINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX74</accession>
    <name>A0A4Q9LX74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MutL-like DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0454p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000454">
        <property type="protein sequence ID" value="TBU13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0454p0020"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="222"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="323" mass="38137" checksum="9619AB84C7EB1EEB" modified="2019-07-31" version="1">MEHFLTFFKTLKSGGGNFLKMNLYKSTIHIDNTISLLNDNKKISNSIIFLQQPIIYEKFISSTTKTTKHKELIYFTTINDIPKPELSTYKIQKNKSNWNFDNSNIHSSTEYGLTLIYNMKPIFLQKFIFELKLNEIYFENGILFIKIDKIIEKIQNNIFKDNASYFPNFITSEITVEFQVLLDENRNKLNIKYKNQNSKKPYMFHNSNTVNISKYEISKESLVGQFNNEFIIIKNHKSLFILDQHAIHERIRLEKFIKNRNIKESITETELEILKSKACRGAIKFGDNLNDKELTKILEEIKYCDHPFICAHGRPSIRYLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX92</accession>
    <name>A0A4Q9LX92_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0565p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000565">
        <property type="protein sequence ID" value="TBU12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX92"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0565p0020"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="23444" checksum="AFEC60DCDF77A41F" modified="2019-07-31" version="1">MEVPTRLNKEYLLKYRSYKSLNIIIKDKYIEDLNDIQSSTKKFSKSTSSVANKIISKEKSLLNFSKNDENICDQEYLIVSEEESGEITNINLNKRKNKDDHISKKIQDTDTKKKNVNYRTQICKFFISNSCTRGDECTFSHDTSKFPCRAYHLRNSCTRKICLFSHKPISLEELKRMKDEEEGDVSEAINFISPLTNEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE8</accession>
    <name>A0A4Q9LXE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0279p0010</name>
        <name evidence="6" type="ORF">CWI38_0426p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000279">
        <property type="protein sequence ID" value="TBU03535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000426">
        <property type="protein sequence ID" value="TBU13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0279p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0426p0040"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22012">
        <property type="entry name" value="HMG-box_ABF2_IXR1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="173" mass="20278" checksum="D3A7816AEB1BB616" modified="2019-07-31" version="1">MVKKSLKDPNAPKRPGSAYLIYCTKQRELMASELENVPVKDQLKRFGEMWASLDPKEKEIYNAEYEKRSKEFKEAWKEYTLTPGYKEFEQKSKQTTTSKKKKKGTRAISAYNEFTAEQYSMIKSQNPGSKFGSLASTVSAKWKNMSDEEKMVYQKRADERQKRKEQENVKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL0</accession>
    <name>A0A4Q9LXL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0403p0050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000403">
        <property type="protein sequence ID" value="TBU13533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0403p0050"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="631" mass="72670" checksum="0884CE58DFA5CC59" modified="2019-07-31" version="1">MNFEWRNVDIELRNKNKNMAGSHVKLIKNANGVVPKGSLCAIMGPSGSGKTTLIKALAGRVSSGSRTKGEILADGHERSYRNWCKNVGYVDQDDCVYEQLSVLETITYAAKFRLKDKNVDIHQKVEQLLNELDIYDISGTRMCSVSGGERKRVMIAVELVTQPKILFMDEPTSGLDAHTALNLIYLIKKLSKSHNMSVIFTIHQPSAEIFSIFDTLVLLSDSNTVYFGEAKSAEDHFAKYGLKKRDLSSFPEFLADVLKVKKKYTESHENQAIMSQMINDNEKSCNKQFGAIISTKNAFIIDLKPSFKDIIILLHRRYKVSLSRKKIIFSIFIFTFFFYIFCKFVSALLDSTAVKDIITAIFNQYTFYISNTDIKNSIREVLSNIEEMKKVFSRPLAMNFLSFFFAYSMIASTGSFSQEYKMIMRELGVATFSITSYYLSVFLFEAFCYLPMLFCSALFVFFKFGYTYIKWEFYLFFFGGMFCYLPTILFFGSLTKRTKTIYVLISFLALTWILPPTIYTGLYFTAVKYDLNSLHAFIYIVSLFPPLHYNTMCVAVAYKLSRKGVKLFETFPRLKECTDALEKFFTSYLFDSVKIWQMFSFFIVTTSVYTLLSFLFLGIRLMPDMRFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ2</accession>
    <name>A0A4Q9LXZ2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="12">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0358p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000358">
        <property type="protein sequence ID" value="TBU13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0358p0020"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="7"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="727" mass="81871" checksum="1422D45B3B98A823" modified="2019-07-31" version="1">MARIKISSIPIDIPYPPYPSQIVTMTKIISCLQEGCGGIIESPTGTGKSLSIICSVLAWAEHYKRNEIVKSIKKDQEGNISQESADTLQIIICSRTHKQLDQLVNQLRKTRYRPRMSILASRTQYCISPKLVDVSDKNTACCDLLKNKACIYFNNKDRLSKKMSESIHDIEDLRREGKQSTACPYYASRILADKATLVFAPYNYILDPAIRSTLNISLHNTILLIDEAHNVEDTCRSAGSLDLTSNILDILNNELVSSLRKIGMSSLRNELLGILGIIKKIKDYCDNSLKNKENVSFNGAGFNNKKDIRLSAGNIKENTFFNNLPVNNNESYKNTANNDSKNSFANSFYDKKDNDFIYKIKKGKEIVNEFNEIGLDIENIRKLKGHIYALNSVDEGRDLIGLSSSQIIESLLFVADKIMIEKCEGYALVFQRSINGRSGYSLNLWLLDPSYIFKQVASSCRALVLLSGTLVPFNAVMGELGADFKHVVEAPHVISPSNVFICALDKGYSNNSIIGTYGNMASANYLDQISKAISDIKNAVGSKGGVLVFVPSYVFLEKLGTILEKLKFKNLFLEPKIGKLSAFENILKNYKKCVQNKQNAVLLCVFRGKASEGVDFKDDLARAVIGIGIPFPSFKDVQVELKREYNDKFKKMNGRAWYEMQAYRAVNQAIGRVVRHKEDWGAVFLLDARYKEKRSNEFLSKWIRENIKSYPTYEESIKNFKAFVDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY34</accession>
    <name>A0A4Q9LY34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0682p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000682">
        <property type="protein sequence ID" value="TBU12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0682p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="22529" checksum="79BADBC2784246F3" modified="2019-07-31" version="1" fragment="single">NRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYYKSHLKRLEIPTNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERTSMGVIMRSEMHEEPTPPLKGEKREEDEAKNFKPKNKAPFILQGGTTLEEPTNNINKESDLEEETKVVEEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY63</accession>
    <name>A0A4Q9LY63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit alpha of pyruvate dehydrogenase E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0549p0010</name>
        <name evidence="6" type="ORF">CWI38_0467p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000549">
        <property type="protein sequence ID" value="TBU02129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000467">
        <property type="protein sequence ID" value="TBU13326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY63"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0549p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0467p0020"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="4">
        <location>
            <begin position="47"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="375" mass="42765" checksum="838362FFDD214D86" modified="2019-07-31" version="1">MKAENSLIKINIDASKFSFHMLDSKDLNFSLEYSKDEVIDIYGIAYTIRLFELECEKFFNNKQIRGFCHLVIGQENIYAALKKVMHTDDYSISSYRCHGLAYITGSTISEIVGEMLGKAGGNSKGMGGSMHLYNKNFFGGHGIVGAQIPLGLGLAFSQKYKEIANTSFPSESNEKAAHEHSKSNANQSIYNNFPLKNVTFCFYGDGASNQGQIYESFNMAHLWKLPVVFICENNKYGMWTAVDKASADNNFYKRSNYIPGIRIDHSNTFEIIEVLKFARDYALKSGPIIVEIDCYRLCGHSLRDKNELRNINEVEEEKAKDPLILLRKNIMEFKPEEYILKIEEQLKNIVFNEIKNAENMCKPNPEMLYENILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY70</accession>
    <name>A0A4Q9LY70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0677p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000677">
        <property type="protein sequence ID" value="TBU12665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0677p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="27707" checksum="9A24AE5C080D319D" modified="2019-07-31" version="1">MQSLRKKYDVFCIKIFTEVQPIDEHIDEFKTIEIFSNVFAGDINCLYGNYSLYSIDKTRSEIYDAEDSCILKISMKTIINQYILGFRYGYQGNTDRNGILTRSTINFEFKSNNHKTEFHYFYSLKNMKDNDYKFKIFYKHSFVMFEFNFNWYTTQQNIYATLCEDFHIIEMERYIIRKYLRIQKQYGSNTTLADKNDVKMEYQTKFYDLKDLFAYLVFKRKIYIIMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI3</accession>
    <name>A0A4Q9LYI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0323p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0070"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6600" checksum="BCB37A03270026FD" modified="2019-07-31" version="1" fragment="single">SLKEEKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW6</accession>
    <name>A0A4Q9LYW6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0283p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000283">
        <property type="protein sequence ID" value="TBU17615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0283p0020"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="652"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="774" mass="91603" checksum="59D57AFF092ABD4B" modified="2019-07-31" version="1">MKCNINRIEGSFTSTILSDMSETVEYNLCGKYSECEDFGFLESSEVFGVSGCNTSLRFKEDNIFDENNFEENKESFVFNETNFEEKINLEESIFERKKEFFVFNETNFEEKINLEESIFERKKESFVFNETNFEEKINLEESIFERKKESFVFNATNFEEKINLEESIFERKKESIVFNETNFEEKINLEESIFEKKKASLLFKKTNFDQKNILERKKEKSLIFNEKNIFSTQNNFTENEVEQQYNTPYNKCNRKDKNHLPDTSNSRVNISIKDKDITEESYYNDIKSNTLYLYDHINNTPVLSLTNNTINNTYNILINNTPVLSLNNNTHNIRINNTPINITHNILINNTPVLSLEYIFFTLLYNKTLLSYVDNYLKSKMDKNNNFLKNRNKPKMSVKMIETSSPDKIKRKKIVLSEKVLNLRPFTYHWSNSYKNMCKNNLRVFSAPSGPTLDSKLFKETEYFCKNKIDFYSSEIEISSDFEDSILKNKIDFNDCEIEISSDFEDSILKNKIDFNDCEIEKNFDFEDSILKNKIDFNDCETKTPYNYKNSIRKNIMEFNDCKAKASYNNNDCILKNNNFLNNSTKETFYERKNVKLQSCISKKRHLIDFWSLQETGEKHSLPTLGPGKCDSIQRISTEVVKKCVECKYNIKYKIIDCRFMYEYRGGHIQGAINANTTKQVDSLFSQYQGHILIFHCEYSSIRAPRLAKYLRNKDREVNKYPKLFFPEIYIMEGGYKNFYWNFKDFCEPKMYVPMGGNKVTNRIKCVRNKMGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY7</accession>
    <name>A0A4Q9LYY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0254p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000254">
        <property type="protein sequence ID" value="TBU18108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0254p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="742" mass="88658" checksum="3570ABCEF6E32B29" modified="2019-07-31" version="1">MNLEYSVQHKLSYKKYDTSIFENISFSILFGHSIDVPDEFLTDFFQKIFYSSDFSYRNIKFIFQNHVFYNNLIIYNDENIISEFCSKLNHKLLYFLPSKDLYETVTQNLHEHKNGFIGNINIPNLEINILNEVKSIKVKIKNSFSPSYFELPLTNLKEKGMKKVKIDIVTPFRTYKKEIPLKYNRMYKEADNEIFSEFCLKNVNRNLKDIFCQIYSFTLSTINDKLYFKSNEEYIKNDIFEENKIKEWKKEEIYKHLNESLVFNPIEIKTENMKGKKSIGNRLEYKEELRRTNSSIFVKKLEKNVFDFIHTQYTLFISNYRVLPRSLCHSILFFSIFFGHTDKIMFLVESLKEFLENKINDLDVCPSRTEDYLFLYETMVFLIKLFSREINVQSIQNESEKKDKLTKNPKNEQKYNLMEIKTLNFTSVNGNNLLKDLKVSFTNILLENEGIKLKNTEIYPRMLRIYNNLLNCHKKGLLKLLEKEKIKFELQNLYENAKLDSLEILPVISIFSYIKNLTEIDFQIEKNVSKMIEKNVDLFYTSILNEVRNSDVKYDLESKYSVLYIVFSVLEKFLYNISINTVIDKKYMKKTLKEIKNKIEILGIFCSNKIENRKSKAFDNKNVWYLKFNRAIFKMINIFIDKYNDYLEDPINMKSTLLIIEKKTMYSLFEKYKNEIEASLQKSRIDINMLIKMLQYENMVGDLARSYKMNLYAFVIDMVKIKYGEDLEEPLKVVGEVFMSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ27</accession>
    <name>A0A4Q9LZ27_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0399p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000399">
        <property type="protein sequence ID" value="TBU13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0399p0030"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1517" mass="181235" checksum="6D75ED30D5F446C3" modified="2019-07-31" version="1">MNMDVFLNNRKFYTLNAFSAKLHIFLNNINDKNTIEEYFYYDFHLIYVLQLFTLILNHENIFLETSKNQNLNELLNISKETYNLQIIDLVWKLNELLDFKFMYQHKKSFLRLDLMFRKIITFETLILRESLNLDVKIFLSHIYLIKMAIYLKYIEENIEFICNSNIHPRKYELVDRITNLLEYIYKKIIFYFKPKRIECKDTSILFQTLKDYMDRIFLLDNEFISSLIDWVYISCLKNIMKLNEFPAIKNPNNGSKSISFIGFIDKILSDKVFHDQNLISLYSGYLKSLKNTFNQEFKIAINVFQKFLKNLNNYSIRKKIKSNQEATLFSIILSDLFFKVNTLENKDAYECLESILDIMISNSFFITKYDFFYFFTGIIPYLSKIIEVIAKTEFFIKIFDLITKIEINCMNPLRKFFYITEETLLYDFLHKSFFNLYYTNFFIESQKNHESIFFFVYAQIRQIIHPKTYFILPSSDLSDYLKILRVYITLSIAKDQIKEYKKSNLLFCDLTVNCIQISEIFLYLISLVRLSSCTDILTKTEIYDYFPIIDVLKVLNSDLARKSENIDMIMEYAYTYIRFLFEDEFYLICSFVYTINCYTKLPKNIFKYFNQRFIYRPRIGNIKEFNSDLICDQEINFKQRILGDMVNIIRLESYFLKIIALQFLSEIISTFPSLLYFIKPYMLNAYIEGLDSLIILDQFVSIYNWEKWNLNFLYGYFFTVSLFRGNLCYVNDLVENLCSIFKTSNINRSYTLISLIYRILLSEICCCKYIQYLNRENLYFFDENCKNTFQKRLKDIYKIFISNNILELLVNKFEDLYSNQAIIPMFQNQLIDVFNIFIGFIENNNISISEKYLIFSLFRFTLPVSSGLLCPVSLFQFQSLDVFEITSDEKNKIYKFTKIASKQISKFKLVELGYINKYHKSIGICSVYKEIMFTNSIINLLKKNFNVDYLNDIETVIENFSPENLGTEESETCLKRKLNKYNIPECVISKFNLKYVLGRKNPEKYSIDGEVFVMFSYDYIVNKKYAAKRNKIELINPIIVYEKANYTKGLICSVLNVYLYSFEKLKLFTVESFFALDVNTNISKITKFFEEIDSCYDLITENDLHFIQERLENFLYFFEYILEDSLNAFFVIFFDFKNKILFVVFEKCIKILGRCCKLYSLTRKLIFNNEELYKYKDRLIYKDFLCFLYKIDTDRISYQAIIYQRNGNFNNLLRTNIFPFYVLSLEIKLMLTALIYHSSFSHFYDQFLLLVDRNNIIDSIVELFENDLTENFLLNDLKVTFVNENGECIGLLYLFFLLYGKAINENAYFMPFKTLDFACFIAETQEEQAKIESIYYYTGIIMAKRYNYEFGHGTNKIMNLHGSEVDTDVTKENLEEYIRRITEFKVYKGMKPYLDKLKEGFNYINIAEWKATTQYSKEYSDEDQLIICFWDFVEKLDDIARHKLLFFVTGLEKLPIGGFKSSKFLEHLFRIDYTSCKNLLPKAQTCFNLLILPKYDDENTLIKNLKLAMETIDYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ31</accession>
    <name>A0A4Q9LZ31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0561p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25425" checksum="A71225FB486E8847" modified="2019-07-31" version="1">MSHNNSKDSWSDYNFKSSENKSEIKPEKRKISETIDENIFEQKQSDKGDNNDWSTGATYSSWDVNKSSSKDTEKEANTFNDWSVDAQLINEKISEYSQQEGTSTGWNTDQGWSTNQNTDWNTNQNTGWDSNQPTDWNTNQPTDWNTNQATGWNTDEKNEYQNTEQSWDINHNISMHVNPSNEWAIHSTKTLLGVRKYKLDLRSIYDGEKLLTEGKKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE1</accession>
    <name>A0A4Q9LZE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0219p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0010"/>
    <dbReference type="OrthoDB" id="2194576at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="23169" checksum="899E32D3C8C25EAA" modified="2019-07-31" version="1" fragment="single">MIYFATFKTKTIKKESKHYLPTVKDERYDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLAEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE5</accession>
    <name>A0A4Q9LZE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0471p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000471">
        <property type="protein sequence ID" value="TBU13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0471p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="27712" checksum="C402E61E0F2F1879" modified="2019-07-31" version="1">MSSNNTSTHTDNEESEQIKNITLYFNNLNSFDVANVFCRDNLSMISNLDTFSPLHVYICYIESLNHLTWKALVTDTDVLNYYLGIEEMSSEDNYTETVKANREKIIFVQKTNGGYYTFDGLHPNKQERIARLGYYIYNMLEDLRNTSTTYQYIDSSVNDDQEAGVAGSNKNVPNIKIIIFISNSIAGIIESTKIHSFLLDSNEEENNTLVIYTSKNTCSIISENYSNLYQARYPTPMSYSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL2</accession>
    <name>A0A4Q9LZL2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0206p0040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000206">
        <property type="protein sequence ID" value="TBU19517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0206p0040"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="177"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="45355" checksum="F3E362F1158ED07C" modified="2019-07-31" version="1">MQWYELKTNQYINLRLTLFSGQCFNFKEIKKDLFAGVISDDLFFLKELNKTIYFNVFNFNKPLEIYENILNKFFILKIDYRLLCFRWKNYNLIDCECENFLKQNDGKYSNLPPNYQITDYLQPNEIKYEEKENIRADEKCSGFDIYLHKKMFDYCLAEKGLRLLNLDILLTIFSFICSSNNNIKRIEKMVDFLYSKGEFITEMEGFKFYTFPSLQILYSINIEELNVNKFGYRSKYIIDCAKYLLENDFYKIETVFESKIFLKVENIFESKDFEITEEVNISKNFKSEIRNNLIKIPGIGKKVADCICLMGFKFLDICPIDIHIYKWSVKTFEFKFKNLNDKNYSLIQEEFKKYFGKYSGIAQLFIFKSSLDKKVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP2</accession>
    <name>A0A4Q9LZP2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0199p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000199">
        <property type="protein sequence ID" value="TBU19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0199p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="599" mass="70675" checksum="60EAF592616ED2DE" modified="2019-07-31" version="1">MHIFIQFLIVYSTNEIFKTAICNDNIQEEVTVSLDNSNVQLKEKELKSKVDGSDTKMLDNILKNEITGQNDSSEKTKSTESNSKIHSNREPQRTRNHYQRKSTSHGYPSKIREKRFGKGVRRSNPIMKNGGKKLKSVVHLPNMVRHHGNSEKIYQPTNNFIQFSSYSRLDIIEPLVFINLIQKNELKDLIRTIERLIRNNKKIQKHCRRAETWEYIDYLANLIEASDGPLEKLNSNILTKIEVSEVCLQTYDQPKNNLMAIIKWLTTIFNTTKLLKDTSLVKEIFNKFRRGNTTKNELQRLNYLLIKIDNLLKSKELIHNPQIHFDKQQCVRKLKEIFEKEFQKKIYCVFPDLEMVLNSFFGNVEYSIKLSLKSIFPTLCLIILTNFLCEILTEDEFSGKTHFLASQASFPYILLIFLIIRDLFFSLDSLSTILDNEQKILEKYMETLIFLFSNRPVGIKPFQDNSIFLVSLFIYSNMFCFSELNKSHNSKSSRIFYLNLISSINQKVFNYRNDRNKNIQELYNDIYIIVRNNLNSFKNILQKRIYLLQFKSDDSAYQDILCWAYSSDVRVPEFKIIFENILTFYIYSRFIKENHTKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS2</accession>
    <name>A0A4Q9LZS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0472p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000472">
        <property type="protein sequence ID" value="TBU13310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0472p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020723024" evidence="2">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15245" checksum="14E5B7693D32D0F5" modified="2019-07-31" version="1">MNILWGFVTMIPFLLATPNEDDTREIQRIVRDQQGKNRRASDQGTQASSSQEKTRSEVSVDPNKSSGISSQKSQSAVSLDSICSSILDFSDLEDYVKYKRRKKSSVQVKRTRKEIERDAAKGREIYFRQAQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV5</accession>
    <name>A0A4Q9LZV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0316p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000316">
        <property type="protein sequence ID" value="TBU15131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0316p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14661" checksum="EB524E053D425C35" modified="2019-07-31" version="1">MTERSVLERVYIFNQDDRRILVCHKTRWLDGIKEDLSNLGIDEWEKEALDRVTTFSKKVRELDPKKCLCLTTPNEIKSISENHVIQEILENVSAEIKVDTRIKTDILIWNIKPNIYVLYCKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M019</accession>
    <name>A0A4Q9M019_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative subunit of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0265p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000265">
        <property type="protein sequence ID" value="TBU17872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M019"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M019"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0265p0020"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13423" checksum="D97D3B314221B14A" modified="2019-07-31" version="1">MDSEELESLPSQESSYLENSELEIIEDKPTKTSNISPQSRITSPIMTKFERAHVLGVRALQLSMGASPMVDIEFETSPLKIAIKELKVKMIPFIVRRKLPDGSYEDWSIREMYVNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M020</accession>
    <name>A0A4Q9M020_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0167p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000167">
        <property type="protein sequence ID" value="TBU19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0167p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF32">
        <property type="entry name" value="FI05230P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="67450" checksum="DF514B305E84ECA1" modified="2019-07-31" version="1">MIEIFYELNFYYIEDISKGKIGRRFDEKLIEDKKFNISSYIIEKIYENKIKENNIKLLRFLLFFKEIEEIYLIDIDFVHVKKMFCLRKIFSRNIDAVTISQKTKIGLVLLYLNNIAVFKNIKKLEIRRTILTENNMRLLANFTFLEHLILSDIIIDQRQYFFPKYLIGKLKNLKILNISAPFLDLSTDPRLFFPDIEQLYLSSIKKKNFNHFQSLKIPEAYYIIVRKISLYFFSANFREFFNKISNFKNLENISIRSKILKSVSGVNNINYQQYHLTLKRLKLVNLYLDVYEIQCIHNFRNLMSIIYIDCTFLHSDSIIFSECKHVKSLQNLKISNCDNARYIFQSIENYKNLIYLTIIIKDSNKLHDSNYFIINFKNHIKLSSIHLECNKLNKFPIISEKSKILLRKIHLCNCNLPSGSVYMSFPSPNLLSNVKSFNFCASFLSRNDLSYLSFMTNCRHLNISSCKFDNCSFFQLFMPDKSYKTVEIFIFDIILQQCDIFALMKLKFLQYIGISLNFLDSSIMYHFKRIYLKRLQLLEIRASFVPLELKRYLQSEFGEDLQILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M092</accession>
    <name>A0A4Q9M092_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0419p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000419">
        <property type="protein sequence ID" value="TBU13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M092"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0419p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="41321" checksum="FF9CAB87575CFB8D" modified="2019-07-31" version="1">MIFSYKKIDFEINLKPKNTIFNYKNTTNIQKKYIKKKMNLAINKNSKYIKSNKINSSLYIPRLISFSTNQIYKYVTKTIKEHKRFKKLQDKKPFNVKKQYFLIENLQKKKCYFPKLEINYMKSINQYFIKTVKHSFLKFKINFYIKIQRKIQSQFYRNISFIKLHFDILEPKCMNANICENINIQRIISHYEDNIDDNCIYNEYITDSKCNYQNRFIKKFISENSLNINHKSNIKYNRIIKTESENKYKIRKNISDRNYSIEINIFNSKGYEKFMMYIKKEYEIIDVNIENDMIILINKRVALCKKYLNLYEKEVIIDKDIEISFIENIIDLYPSIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D5</accession>
    <name>A0A4Q9M0D5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative biotin--[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0417p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000417">
        <property type="protein sequence ID" value="TBU13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0417p0020"/>
    <dbReference type="OrthoDB" id="2190368at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27010" checksum="8619366E737F5849" modified="2019-07-31" version="1">MEIIKCDKESGIVIKSYNELDSTQMEIKRLINSNMYSEFECIITKCQTNGYGRKGNGWVHLKGNLALSIGYKGKVLENMVCGLLMRLSIVLTKFGVNTLIKWPNDLYISESKICGVLVEQVKEYIVIGIGMNILGDHPSYKSIKDLTGISIDQIELVYEIFKEIKLFSRLEKVNIDISYFQPKYTYLNGLEYKIVDLQNDCLILKSKDSRLVKISPLYFFYDYKNNELIKRTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E2</accession>
    <name>A0A4Q9M0E2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0262p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000262">
        <property type="protein sequence ID" value="TBU17941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0262p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020763225" evidence="1">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="39394" checksum="6411D7523CA198AA" modified="2019-07-31" version="1">MFIKYLLIIVLNKLVIYHSGKNITPSFGKFGRKLLNLERRDSKYKQLTKEKHEGELLKHGAVNEVSSAFKNLACSTNSIQKGKICADVSSKKKKRCGRKPKEYSNNLAQIRNTPLNRRGTLRSFSFAIDIPKSTFFNIFKISSTVKPTLTDKNKMDRLKFCLSKVNLANNGDFLFDDLYDYVHVDEKWFYLTKRFITKIMFMAAVARPRYDAHRNLYFDGKIGIWQFVYKEPAQRNSKNMAKGTIITKNMESVTAVHCKNMMIDNKTIYVQQDNAKPYFSDNDADINIKFKAQPANSPDLNVLDLVSPHIIEELINSDRGNGYKTPHLSKGKLLRKGRLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F1</accession>
    <name>A0A4Q9M0F1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0366p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000366">
        <property type="protein sequence ID" value="TBU13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0366p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="58001" checksum="B99EDC85E9EDF0C7" modified="2019-07-31" version="1">MKFKNQEKNIKFSFLEIIIMLCCFAFKFGNSFSKSFILKQYVLHVACIQNCFLFASSTSSDSEASIGSDFITSSSNSSVISCSNSGEKIKIKIIYTKKRSFMIRSTLVFANTQGNLTYTSDSSTEIYNLENFSNRKNAVNPSIFENPIIFDFSIKGVFEPIDMVATIKTLAFFKVCNDKNFRLFAKSFLEFTFAKLNIYDFYSDKNEYQLENESGKRIALSFLRIFLYENNIKKIGNYELFCKSFKEYKMFKSKNFFMLADKFTRNFYFIEKHKIFFKNVFYCHKKIIHFLFLQKLVSFEKYYIDDFVLNCLYLSDMTIDFCKSTIDFIFEEFKGKKTDLENLPNKCEYKWNRHFLRSSVFVNAVAFFFYNCEIKCLNISIKDSQCFKHDVLVTLKLECVVFKIGICHFEFFIALHSLIQGKRSIKNITLNISRLQPDISIGLNHITFEKIFLPPKFEITLSIFDSPKNLSNQEYANLIKFILQPKNELVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H7</accession>
    <name>A0A4Q9M0H7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0404p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000404">
        <property type="protein sequence ID" value="TBU13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0404p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12461" checksum="2D1100DB398EACEE" modified="2019-07-31" version="1">MYYYPLVPNNETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREEDGAKNFKPKNKAPFISQGGTTLEELTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P7</accession>
    <name>A0A4Q9M0P7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0379p0040</name>
        <name evidence="2" type="ORF">CWI38_0384p0040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21507" checksum="F6801B8414F241FB" modified="2019-07-31" version="1">MDNICLNKEREFSNVEYNCNLCGKRKKSCNYKSNRINLPEKYCFIKYRRILYVIWIIWFIGISVLGYFIIKQKNRTDIKLDTDSNLISLYNNFIENISLYKYISITKIEIDRNTKLGNFKTKEFNEKSFCIVNESDVKFLKISGNGNKIDEFCDVNDGSNIHKWRNFYDPRDGADAQAILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S9</accession>
    <name>A0A4Q9M0S9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0205p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000205">
        <property type="protein sequence ID" value="TBU19520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0S9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0205p0020"/>
    <dbReference type="OrthoDB" id="2193062at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="27831" checksum="D0B7BA31175666B6" modified="2019-07-31" version="1">MKRKNIPPNPRKTKRIRRDRQPSVSRGPVSENINDDFTFELIFFIMPVTGRITANFMLRNNLQIIIEVFSLNPLPPKTVSKVDLEEIPVVKYGKGVIPQTECSICLLPYRVGQRLRSFKCGHYFHCKCVDKWLLGFSDKCPMCRVEICVMKGVEMCVMICVMICVMKGELFCLEKGVEMCVMKGVEICVMKGELFCLEKGVEMCVMKGVEMCVMKGVEMCVMKGINKCKENEKWIGMSKVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M154</accession>
    <name>A0A4Q9M154_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0336p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000336">
        <property type="protein sequence ID" value="TBU13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M154"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0336p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="367" mass="43568" checksum="2CFA97B716D46F63" modified="2019-07-31" version="1">MVSCRRIGTGRRGYGVKRVDWQVLLDLLGVIVDAFLDGPPDKNSISIAPSSAKSKGRVVYLHSMALYIKSYKSLPLKVRNHNEVNSFALFYDKKYIAKILSDKNLKTNIIPRLIFKINESDQNIFEKNNKAIYLLYFTEIHISIESKSPPDFKKSNNYRVFFKGLETCNLFELNPNESIEYGKKGFIDFLNFFKKIKIRSSYDQFEILKSLKNINFFEKIFKKNRSTTFEHFYLIFEIFSELLKVIDRNFDFNYDVHLVFEDLARIDLRDVIKEHYNTHLASKAGSSSRFTTCETRIFDIETRLISMFVMVFRDLLDHIFCDKSPKISKNIENFIMKFHWKIRLRRLFLIYFNKIRCLYAKINLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M159</accession>
    <name>A0A4Q9M159_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZIP-like zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0501p0020</name>
        <name evidence="7" type="ORF">CWI38_0291p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000501">
        <property type="protein sequence ID" value="TBU02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000291">
        <property type="protein sequence ID" value="TBU17008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M159"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M159"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0501p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0291p0020"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU17008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="269" mass="30054" checksum="346A21BA1C7DFB24" modified="2019-07-31" version="1">MFDGSQTEIFLLSVFLFIFTFLFACSYKVFSKTKLSSYTKCLAGGVILSTMIFHIFPDLYEEPNSCLAPLFSGISFLILFSIDKLYLNATQHDHDSLPENVTQAQALIFVIALSLHSFLEGLGIPAKTGQALKWYITGLIGHKWVEAFALGVSIMTAPFPKKVIMSLIVIYSALTPIGTLLGFYVIEKVKNTSSFMDVKLIMTGISSGSFFYIGFIEMLNSEFHFHSNSKNKIRRINMNKICAIFSGFCFMTIVVYVCSLIESGKISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B3</accession>
    <name>A0A4Q9M1B3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0207p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000207">
        <property type="protein sequence ID" value="TBU19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1B3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0207p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="784" mass="93318" checksum="DAF87A2E3209A263" modified="2019-07-31" version="1">MNIWTALWLKAYYKPDRFYVFRFILSMFIRLNFVISYRFTYIFERRRNLEIIFYEEIQNSQVYIEKSEDCFDMKIYYAVDSISLSKTNQVFTYRKENFIGFEILNDFLNANTFQNVHGKVECNFDLAYIFKITKDISELPDRMNTHRFDCLFSICRNLKVIKNRNIFKLLEVIIIKTYFCQVKNYIVYKYRKLEKIIKSISFEKIDFYMKKNLISSFLNILMIRHTFYEDNLILLQNTKLFEISSFYDHIPYKNLLINDYMIFGYFEKMLKNQCLFNILEILLSEINIKSLLLDNIKEFETRDNYHSYSIFSMKIFRSIVISNFSGSPHVVLYELSKAIHVNLEIFGLENIIMNAKYFNLILKNHKLKGLILDNISMNGGGIYYLNDYIKLNNTLEFIDFRNPQNNFTWWISFVKSSNIKKILITFNSLQIEENFIKEFCGLNSEVHILLLQINFCFFAMSKGFCKSLRYFKSLQTLKLYNYESNKDIEPYLLKALNNMKDLTVLEIEYSEFGKKFYNFLSANQKIGGLKINNNFSKHEILNLKPFINYKTLNLLFLKSIRISESGLIEIFKLENLKILSLKACTLTAIGNPKSLNFMSKKLSSLCLQGTDLNLLKYVDMLTHLRYLKNLKLIAKELEMYRLAKLNSLCNVTFNKLFYNWGILDSNDLNRIKSFEVLEVLDLCGCKFIEGSLCDLGKDCKFFNSLQKLNLYFVKLTLDDFIYLRNFKNLKNLKLMFYDLRLLQININLFCLKTCHFSLKKIYDKNNGMSILNYLKEESIDGIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T0</accession>
    <name>A0A4Q9M1T0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0133p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000133">
        <property type="protein sequence ID" value="TBU20097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0133p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="32404" checksum="9D6EE05E737B10CC" modified="2019-07-31" version="1">MLIVSLDDISDRRSKLTLEIKESLQTYVDLECTKTLYELAELAKCTLNVNVSTSTIDRAPETPERRNKLSTIDLRTNYATCFRELEVDNDDKNFVFLDESAYLSVTEARSRNISVVAVMNKYGMIYHKIHERAVNDEDLELSIKEINESYNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENPQLRILICEKFNEIGRTLHDFKLLNLKYYLKFYFLKIIIILSARIMILIETIMILIENYYIDCKDYDIDQKIIIWIARIMILIEKLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T9</accession>
    <name>A0A4Q9M1T9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0170p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000170">
        <property type="protein sequence ID" value="TBU19928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0170p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14567" checksum="8C1E5E39A4791562" modified="2019-07-31" version="1">MDSELQQTLDSLKHKLTTYKRAFINKIRKDYQDFLSSNKEELSKMTLYSFSKSLNKGFLGKKILIKNASKKRDTKNIRSSIAISIGDRQIIYNGNTFTSNLGDEINDPELLNVVNVIRQKFDKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y1</accession>
    <name>A0A4Q9M1Y1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0002p0010</name>
        <name evidence="2" type="ORF">CWI38_0036p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000002">
        <property type="protein sequence ID" value="TBU05545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000036">
        <property type="protein sequence ID" value="TBU20675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0002p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0036p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="147" mass="17723" checksum="327752AAC436711A" modified="2019-07-31" version="1">MKLKVRNIFLEKIISILARENYVGFQLQNRDNLSSVFVTLDPKNFRFMKFNSFFVKLCEKFRSKKYFFPKLLETFKTLETSPKTINSKGLLKQEKKIWISKSQFKRFEFNFFILSDLEIIIYKFTKKNNIGNPNEWVMIKNTIDFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C5</accession>
    <name>A0A4Q9M2C5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0125p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000125">
        <property type="protein sequence ID" value="TBU20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0125p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="194" mass="22495" checksum="375842B01B4EDA5B" modified="2019-07-31" version="1" fragment="single">VDTRIKTDVKFRNNRPDIFILDKKKNKIILIEVEITSQDSLQIVETEKLRKYDLLANDLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHDESTPPLKGEKREEDGGTTLEEPTNNINEESDLEEETAVVKEVEENIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G0</accession>
    <name>A0A4Q9M2G0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0210p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11529" checksum="8FB8EFB890E6B4B4" modified="2019-07-31" version="1">MEMIDMYYTRRYNEVVRFLSHSVQEVFKNEYAEIRETQKLGLIYKCSTYVKRLRIVMNIEAYIQFIVIRIQVYPEKSCTKRLDSEEDGVKKEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G9</accession>
    <name>A0A4Q9M2G9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0209p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000209">
        <property type="protein sequence ID" value="TBU19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0209p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="28622" checksum="DFB56A0E639C54B5" modified="2019-07-31" version="1">MKFNFKDRFFEIIFFIVIFLIEVSLPVVFYTKIYDIDLNSNLLLIIFKYILLMFLYKFSFLFHRSSKRVETEYDIYYVIIFCFGFVFIISELYMNTLNMNTIYVMSSSCVFLYVIFNLITYFSIFLKFNNCKFIKKDVSIRTFISYFCYIYVLIVVDNLIYKIFIITIRELFTFKVTFYIVEMILSFIYLCKRNEMVTTLLLLIYQFVFLFAMELNTLYFFYENFNYLQFPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M4</accession>
    <name>A0A4Q9M2M4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5096 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0001p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0050"/>
    <dbReference type="OrthoDB" id="2195262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031512">
        <property type="entry name" value="DUF5096"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17019">
        <property type="entry name" value="DUF5096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5096" evidence="2">
        <location>
            <begin position="203"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="405" mass="47052" checksum="AB7D287964B1E486" modified="2019-07-31" version="1">MEKYIGKKLIFETKDSTLIGILIEISKKEGKFVIQKEDNTTLSLNTLSLTKIMIHKEEIENLKNKNTTKEIESKKEGIESKKEGIDIKKEGIDIKTDTSNKENRNENINKDNKNNRNENPNKEYINKENRNRRSLKAGLSTFNNKRTPTELENLIKSKSPKKQEKQEKPEISKYEKPEISKYENKEKQENKENKEIHYLSDIRYEEFLNSIFNFYGPPEDGFISIATQNILKIILLTSFKSVKEGKVSILIGKDSIYSRIALNLAKILPLHNIDSQVKFASKENISIKTEIYKYFFINSLGRIVSNIDITTDLLIIAGEDFTFDDTNHFIIKKTVFKDILYLNIPSKKDDFNSKRKCCVCYGSVPEKYKNFDGSVLCLDVCLSEEIYKKFNIDRISKKNIFKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P1</accession>
    <name>A0A4Q9M2P1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0201p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2P1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0010"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11288" checksum="3C4DA9B6926DB57F" modified="2019-07-31" version="1">MNTKYVIYVIDSNDIARKEIYLSVLIQLSQEVELIRCSFLILLNKSELNMHISIDEIEEIIKKSYSKRKIAVFSCTTRKKESIIEAFDWLIKDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3A1</accession>
    <name>A0A4Q9M3A1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0141p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000141">
        <property type="protein sequence ID" value="TBU20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3A1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0141p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="6907" checksum="F0AE4D8636455C5D" modified="2019-07-31" version="1">MQSYNSSQTTNESKNRRQEDLFANENCVKHSSDISDKKIGFEVLKNSFTKRRKRILKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3F2</accession>
    <name>A0A4Q9M3F2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0143p0040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000143">
        <property type="protein sequence ID" value="TBU20046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3F2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3F2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0143p0040"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="105"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="482"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU20046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="829" mass="91539" checksum="C96B0676ED540625" modified="2019-07-31" version="1">MDIDIDKFTIKNSEITEKSGTIYTKLGLKVEILPGELKIYSTKDSVIKSVGKNIHIHIRSIRILESIIEEGFCSKDVHHTMPLEFIDDLGNTITTNYIPIKNRLNIAILTSGGDAPGMNPAIRAIVRTGIKWNAKIFGVLYGYEGLINDKIIEMNWDEVNNHNTMGGTCLFSARSTDFSHPDGRKLATLNLVKRKITGLIILGGDGSLAGGYALFSEFRSNIEILMKEGKLPINTQTYDLKLIGVPASIDNDISYSDATLGSDSALHRVIESVDNLSSTMISHQRAFVIEVMGRNCGWIAMMSSFATGADYVFLPEVPDPKWKKSIVDSINTVKHCGKRGIFVVISEGAVDENGVLIKAETVKQIIEKETNMETRVLKLGHTQRGGAPSAYDRILGTVLGCKTIEHLLSKPVGPPVIVSIIDGEYKFTELSKVIKRNNEIKNYIKNKDFENLLSIRGTFFKRCYLLNQQLRLKNEKSDSKKKIAILHEGKRAAGMNTALNAIIQYGISLSKDIYVIHEGFGGILKNMITKAENYEFYTSMNSGGSVIGTSMCTDIDCKKIYKKLKESKITSLIVIGGSGSLKIVNNLKNMNHKRKDTPMDFVIIPATISNNMPGTDISIGCDTALNCISIASDLLRLSSVSMNKSVFVVEVQGDRCGYLALMGAIAAGAFENFIPERKYKMSHLSDTAERLKVKFRSGHRHGVVLIRNEKTFQAVSTDSFSKMLKADSQGLFDTRFSVLGHLQSGGNPSPIDRVNAIILGIKALDIILGTDKENIIKGSRKPVVGILGLKGQGLVFTPLEECITKFDFTNKRDKNPTWMHFSNICRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3F3</accession>
    <name>A0A4Q9M3F3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0053p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000053">
        <property type="protein sequence ID" value="TBU20548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3F3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0053p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="40124" checksum="5E60EBA29CF12393" modified="2019-07-31" version="1">MIDTYLNPKWKFEKESILLPIYFNIEYFDFFNSLLSYKKISEKFNEDFMFRFCFITDYFLFEFEDVFFEVIFRELFNNCSLFFKNTDERFLFTFIEFLVSVDKILASYIKQGKQAKSIDVFFRIEYIFVEKLDIKLLEFLIEKIPIENMIVHDNLISSGNTFYTSQSSECIDKIMDDLKPLLQHLKKSKLLKYITVETHPLEFLSTEGTVFPYNTMFDFAELRLHHFGSFTNKEKITFKNLISMDLGFSSLHRDQINSQLLNRINLEVDVIFDFSIQNSLNYENLSKIVLKYKDRNISYGVTTITYKIFFNKNRIAHLIHKGSNYFGGEPLNIECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3K6</accession>
    <name>A0A4Q9M3K6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5093 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0119p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3K6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0040"/>
    <dbReference type="OrthoDB" id="2192698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031533">
        <property type="entry name" value="DUF5093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17011">
        <property type="entry name" value="DUF5093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14928" checksum="331E5AF9E0112BA9" modified="2019-07-31" version="1">MESQIKIIFPYKIENRNNSFTIPSKILRKSNIVIIVIPFDLDLYIANTKLIDKRCINKCFSYSFEFLDISSPLVFLKDPTIYVVENFVPTNSTVLENEMNRFMEEYEGNEKKENKEIVDDEGFITIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3U7</accession>
    <name>A0A4Q9M3U7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0115p0050</name>
        <name evidence="6" type="ORF">CWI38_1630p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001630">
        <property type="protein sequence ID" value="TBU10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000115">
        <property type="protein sequence ID" value="TBU20196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3U7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3U7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0115p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1630p0020"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17144" checksum="04B28D08476A5DDF" modified="2019-07-31" version="1">MFSSYRLTKELKNIDLPPNTSLKLNKEEETTTSLFTDILIFKMYISTGLYRNRNLTFKIKIPVEYPFKGPKVFCLDKIYHPNIDFDGNVCINILRDDWTSALGVQIVLYGIILLFDTVTHENALNTEVGDMMVNNYTEFERLARVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4K1</accession>
    <name>A0A4Q9M4K1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0035p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4K1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020321399" evidence="1">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="11806" checksum="B2B9DA6A70B721A5" modified="2019-07-31" version="1">MFLIINIFLHIVIFLCSKKKKVHFFDEISEETKESNALKHINPLPKIDNANFKLPLKKEENIKYHILTRKRYNEIGKNPNLVFINNRDAMNKHGFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWU4</accession>
    <name>A0A4V2JWU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 3-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2158p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002158">
        <property type="protein sequence ID" value="TBU09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWU4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2158p0020"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="358"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="621" mass="73828" checksum="354B1D48D6AEE83E" modified="2019-07-31" version="1">MINISSEILINSTFIKEIPYSLNEKANFLSKYTILAEYIFYNTTDTHNRIISTKTPIKNIFLLSTKSRLNIIFVYRYFRKGISRIFILETKNCKNYFESITISLLLDILQILYTKEQNICLITIKKKIIKSTIDIFEVYYLKKSSNAIYLNKEDNILKIRKKLSTINFILKRNRELDYESNLYLLMTLKYLYSKNLCIPNKKYKLPKNMCQNLLTGILISKIFNIFIIDQIQIINIYFCLKFCLEENILEKNNVKKILNNIFEKFKEKDNYCKNLTVKSTKSKKLLFSKLKLFNKLLNLKKLFKKMNFIYKITEKDSFYSKTSRLDNLKGYLSSNKSFIKEISTVSPFDHKILLYEIDYKNIEIFQSSTFPLIIPFISSKGVYKIIYKKGCDLRNDYIIVSLINYFSSIIKIPLITYKVLPLNINEGIIEYIPETFNIDELILKFSSLKNFLFQSNTNMNLFIESLAAYTIITYLLGIGDRNRDNMLFHNSGQIFHIDFSYIFGKDPKPFPPKIVILPEVSYFFKNNLLLYSKFIDLCQKIYNKLRKNTQKIYFYIQILQKNPFCNYKSEIIFKFLKKYLNLEKDDFQANLHIKKIIEESLKSYKTKINHFINKLGKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG2</accession>
    <name>A0A4V2JXG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1071p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001071">
        <property type="protein sequence ID" value="TBU11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1071p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="14950" checksum="32E68966CF76219D" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDFVKADPKEWPRIVFLRTDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH1</accession>
    <name>A0A4V2JXH1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1030p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001030">
        <property type="protein sequence ID" value="TBU11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1030p0030"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="578" mass="69182" checksum="28E3AEC0550810F1" modified="2019-07-31" version="1">MSDILNYFLNVQFENIKDTEILQNIYNEINKDFKEIILNRESCYRLESLLQKSSCGQLLDFLNSIDIKYFICKKLGSRILEKVFTLLFMHINVHKSIKIEEIEVFIKFLEKNFLKYFYDPCGTFVIRVYFQILCGKFVFYDAAHQKQYGVKDITNCKYRVLKYSNNKSRKYSRIDSRNNKSHELKSHNLNSKSLKLDSKSNSLDSHSPKSKSLKSKSLKSNFHNLDYLYKLLENDISNILSQKHTSLSLLTLLLCMHKKNKIIKKINISYLCVERLKEPVFSYFYETLISKMNQKNLLFFYKKIKPYFIQLSTHPISNYVIQTLINTFTLKYKFYYSQIIKNYQLFNRNSNILLNLVICLQKENKYRKIQKIMQIFYYKNDFFEEVLLIRSNDRYDSKLDFKDDRYDSKLDFKDDRYDSKLDDRYDSKLDFKDDRFDTKNSKLGKKNNLDTNINISDTNCNINSHCTIDSKFVQMTVNFLKSKEENEITKNIILGFKNNFSLKFLENINGLKIILAFLQGNTDLESKRWLVNNICDRLYLLGRNYYGIEVLQCMTLYCDWDMKREIYSFVRKSKMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM6</accession>
    <name>A0A4V2JXM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0762p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000762">
        <property type="protein sequence ID" value="TBU12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0762p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="632" mass="73621" checksum="2AAC28BD1672A30A" modified="2019-07-31" version="1">MDLEWKNVDIELINKNKSSCDEYVRCITNANGFLKSGSICAIIGPIGSGKTTLIKALVGIIPSGSRTNGEIFVNGMTRYNYNWLSCIGYVDENDHIYENLTVLEFLRYSASLRLKYQAADLYEIDSISEDILKKLGISDISDSKIHILSPIQKRLILIANELVTIPRILFIDDVLKEIDDNTASNLFNYMKYLSIYHNVTVIFTIDRPTSKIFALSSHITLLSDSHTVYFGKTKKAEKYFEYYGLKKPESATFPEFISEILKTKNKYSEIKAHQNRLNKIINNVKTNPVPEKMLSSNGNGTKICKSLSVWDISIIANRQCKMYVTYKKIFVFLFLFGFIYLILFKYIFIFMNKDYFGDKLINIYSLVKNYVTDQSVHRFIDLIKIHSSQISKIIQNSVVLQPMGILFAFLLIPSSNIFYFEHQMVKKELAMAKYSIGSYYIATFFSELFFYFPYCFAIQILSGLFFSKKLGWGFHIFLIFGLYAYLPVFLFFGSFIKRTGMRYLIISFLALFWITPPFMYSILRNLYTKKQNLFGLVFLVISALFPPLHYNAFCVALAYKTDSYKSRFLEKNPSVKELSDRFAEYLYSYLFDSMNIWYIVLFFFITSTIYIYFTIYALRKLLTPEHRFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY68</accession>
    <name>A0A4V2JY68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0167p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000167">
        <property type="protein sequence ID" value="TBU19943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0167p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="14479" checksum="F45B09F58D4F674E" modified="2019-07-31" version="1">MEENKSIGKFLKFHFFCRSVLDPDLILIFISSFFKNYDRFNDILKKNATILEKLQFYSSQQKNMAEKKCKPENENESLQILQKIYYKYANYVSNWLKVYHKLTIYLNLTYQLFTTNKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE1</accession>
    <name>A0A4V2JYE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0030p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="319" mass="38113" checksum="30EB34CB345E3ABB" modified="2019-07-31" version="1">MLIIKVFNSLNSKKNINEFRENVYEISLSNFEREESIDQLVKEISEMTVKEENRVILENLDHKFSITLLVFKGINASFCVPIFSCDREELKVCNKENKTEENESIEIIEVQNELKSKNVDIPQFMMFLIYNSQVKDLADKEYEIINLLSDISEDFVEKIFHKFVYLCFPSLNYKFLEENKQVDEVKNLILSFISKKFIEIHNNSKNIFRTIKYIFKNFYFKFWTFYLQNREEFQRFLCNPEEKNESEKTCEEKNSIAADKLREKLCEYLLNNKENMCDLLKKVLGGYVSFDEDKNLGIYEEFDNILNIFFHQTGLFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUE7</accession>
    <name>A0A4Q9KUE7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1755p0010</name>
        <name evidence="13" type="ORF">CWI38_0797p0010</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="PITJ01001755">
        <property type="protein sequence ID" value="TBT98438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000797">
        <property type="protein sequence ID" value="TBU12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KUE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1755p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0797p0010"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT98438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="360" mass="41313" checksum="55BE421DDD7366D4" modified="2019-07-31" version="1">MNKVQIFEFDELELLRYTRNLPQNYNFEIKKTLTTIKRNNSKQIGLQFPDGLLKYSLVLSDIITYFTGASTIILSDVVYGACCIDDISAHSLGCDLLIHYGHSCLIPITSMLIQTLYIFVDIRFNTNHCTEMVKTLIKNQKRITLTGTVQFLGCINEVYKKIKTDKNIQISRIRPLSPGEVLGCTSPKLKDTDIVVYIADGRFHLESVMISNPNLEFFKYCPFTRKMTQEYYGYEKFLEERKNSLKKALQGRTFGIILGTLGRQGNSVIHKNVSQKLKLLGYKIFNFLAPEISNNTLDSYIFIDAFVQISCPRLSIDWGMNFKKPLLTPFEILGNINEYTMDYYSSEGSAPWKNYNNTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXY9</accession>
    <name>A0A4Q9KXY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1199p0020</name>
        <name evidence="2" type="ORF">CWI38_0294p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001199">
        <property type="protein sequence ID" value="TBT99836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1199p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0030"/>
    <dbReference type="OrthoDB" id="2188750at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU16699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="158" mass="18842" checksum="D68B380DA0F5AC64" modified="2019-07-31" version="1">MDLTFEDLENKCLDSIKKNNISTFLHLFPFYQYKLDNYTSSTPIIICFRLLTLLNNDMCMYYQLQETYTTEDPHYEFVFEIEKCLSTGSLNKLNKIASENKYPYFKEIIFQIISDFRKEMLEFANNPPQNLPFINDKESAQQTIIDSIFVIKELSRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0X4</accession>
    <name>A0A4Q9L0X4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0835p0010</name>
        <name evidence="4" type="ORF">CWI38_0446p0040</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000835">
        <property type="protein sequence ID" value="TBU01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000446">
        <property type="protein sequence ID" value="TBU13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0X4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L0X4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0835p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0446p0040"/>
    <dbReference type="OrthoDB" id="2196090at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="712" mass="85118" checksum="CB1E770CDB12D95B" modified="2019-07-31" version="1">MNTENDTINEEIRKFIETTTKPENITYKNVNQDIETKDNEINNLIFVLENLNKIYGKINDALIIDDKDKLKTAVFGTDVKMNMVCESLLKVLRDVCVERNEYKQNKTELLEKIENLENEKDLLKEKLHDFEQKNLYAKNGNNELNRVIKDQKERIKSYRDKANTEKKTCDDIKALNMEIETSKNKILEKNKILEKEISILNSRLKEKEDEISEFKLQVKTKEIKECEFKNRNIEISQELENTKTKLDTKDKALGICNSELVRLISKDKKINRELQTFKDKSNYYERLYQSVSKQNEYLNEQLTRILNLNNIHSITNTINDSMNTEDKVLENKNEENNLNLEKMKENFRKIKRKLKSYKSKYSRKNKEIDTLHENYNKENNEIQRMANEIKKLREENQRVLDKNKKMTENYISKMEDLVEKNKQYQNKIIQLRTESISDIKDIKSEKGNFKYFFDEKPYNFKADDFQNFYNLDDFKEENVESKKTPNFFEDFKFKEKFSDSESFEYENINFNPKKLIDLSIKSIIKEKNNNEYTRMKGALSKDYFEEISDAKIIEEVKEKQFEQNNIDKNQETNNIPKEISTNDKNFTEKINQDSEKQEINEKKQDFQFNNIPSETYKWKDKNNDSDSSDSSLKNPSDFSEKSIKSVHTTSTLKEMIEKTEKMKQKFNELDEKLNSIKNSNKNLPEKLHNQIQEYTNYYYTDFLDLENDPNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2S8</accession>
    <name>A0A4Q9L2S8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0644p0020</name>
        <name evidence="5" type="ORF">CWI38_0118p0070</name>
        <name evidence="4" type="ORF">CWI38_0579p0050</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000644">
        <property type="protein sequence ID" value="TBU01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000579">
        <property type="protein sequence ID" value="TBU12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2S8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0644p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0579p0050"/>
    <dbReference type="OrthoDB" id="2189995at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="128" mass="15781" checksum="4DE9C3F4B8784443" modified="2019-07-31" version="1">MIFDKYDYNDDLSLFMNFLSKIHSQERNSRSNNHQETKNYVTKKYFNSYFVGNNTMEIQNKMNLERKNNFKVNFVPNISYSNYIPIPYDNDKFLCRYCNIRYVYKRCLIKHMKQKHKKHLPRNHSILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6G9</accession>
    <name>A0A4Q9L6G9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0479p0010</name>
        <name evidence="2" type="ORF">CWI38_0464p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000479">
        <property type="protein sequence ID" value="TBU02451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000464">
        <property type="protein sequence ID" value="TBU13332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6G9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0479p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0464p0010"/>
    <dbReference type="OrthoDB" id="2200914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="191" mass="22903" checksum="A6AE26D8321EB76C" modified="2019-07-31" version="1">MDLENTNESVKNVLNIIFILTNNAEDLYLTEDNIPRVIPKQNIDLYQIMNKFIRLNKFENYLEFFESIETIKYGKFNSSLIFYKMKFLEQTFEEKFYDFKKIIESVKNFQKNKLKRKYFNKEIYDCIIRCNDFIGNGMIKDVYIGPFKLALIHKKYNNLKLFDKLMNEALGVAKMCDNSKGVEMCRKHLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBF2</accession>
    <name>A0A4Q9LBF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0045p0100</name>
        <name evidence="2" type="ORF">CWI38_0021p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="366" mass="44029" checksum="DB42056EE66849B0" modified="2019-07-31" version="1">MKNAFFDIKKFSENIEVEYKDEQILEKMHSCIEIGNNTMDLLVSDLNISPPSQWTNDTLLFILFYLYLEGQEYPQTLGSSYYMHYKNDKVTQIYKEITYFCYNATKNIFFDKFLFYVSHQSSNENILVKFNHGFTYSVFLLLQLFKEFTIENVEKVFLEFQKYDLSKIDNFCNKKPSKFLQYNQLYMLHLCESIKPKNIIFVPPSKALKKIQSNIFLMMRYVKSKNKFNFCLKNSKKIRKMLVPLKGLLSDQSFHRIFFTDIILFNKFSLYSQNFYQEFFKLKYILKIYLKHKIIGLNFLKWCLVQKVSENKCLDKFKRRIFDENVFDFSTCDTFLCNLSPDSFIFTYLNKSHSDFIRDINKSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD04</accession>
    <name>A0A4Q9LD04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0013p0020</name>
        <name evidence="4" type="ORF">CWI38_0104p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000013">
        <property type="protein sequence ID" value="TBU05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000104">
        <property type="protein sequence ID" value="TBU20251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD04"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LD04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0013p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0104p0020"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="309" mass="36718" checksum="54F2C964D0A7EEFA" modified="2019-07-31" version="1">MEKNNNLKISYISCFFIKNISELLQLSHTTFCTSVFLFHKFYRKKNFIKYNNLDVAISCILVASKLEEQNCNLKRIICVYNFLKSEYFETKYQNLTVLDASKIKERIVLIEMNILKYFGFNPIIINPLKILHCFFTNNKDICIQFIKNTDFSFVNTPDINTNHISISDSNFKAIESQINISNHIKMKDTVISNCKDKFNDISKYYKEFIYKVTKKLNDLIFCPGIINLDIHLICYIAIYLSFNLDKEYFAKLDLEIEKELNFMYKLYDTDFKERNFFKNKNKIPSDDTNVKKSIEDFLVRENAKKHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDS5</accession>
    <name>A0A4Q9LDS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2659p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002659">
        <property type="protein sequence ID" value="TBU06014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2659p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="14993" checksum="1FFCBCE34E49A498" modified="2019-07-31" version="1" fragment="single">GIVTKYHKSQLKRLEIPMNVEAYIQSILLKKTLETISFDRRMGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEM8</accession>
    <name>A0A4Q9LEM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2679p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002679">
        <property type="protein sequence ID" value="TBU05925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEM8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2679p0010"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21215" checksum="EB2DF5BC201CC2D7" modified="2019-07-31" version="1">MNILFTTFEITTVNKSGFTKPLNDDFRSTIRHICTLKTIENLGYFLRYLKPIESCESVCDINVFKQGIQPLWEDENNLGGGKWIIKLRKEVGHRLLERLIIHLIKGPFSTTDVNGVVASIRPKFYILSIWTRTCPKTNEVKNIIKEIRNLLKVGNEVEVCFKDNDESLRDNSSFKNTTRYTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFM3</accession>
    <name>A0A4Q9LFM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2604p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002604">
        <property type="protein sequence ID" value="TBU06285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2604p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13171" checksum="BA47DABE0C46A5BD" modified="2019-07-31" version="1" fragment="single">MSIAYLIVVTSTGNRNDYFRCYAESSSDSREYNRRCRDYSSSSSSSESNCGFNTLVCRDFRCKPTKATKCFTATECVPAKPAKTLDTEIYHIEGIIESAVRNIDPVLNRAAIAFKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIT6</accession>
    <name>A0A4Q9LIT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2313p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002313">
        <property type="protein sequence ID" value="TBU08044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2313p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="29700" checksum="C204C2041807ADB6" modified="2019-07-31" version="1" fragment="single">CKISTSDIVHPLPNRSTLPGTTDFFKLDYAVRALPTLKAKMLLQHLDCLEKHKNTSTKRAAILKLEEEVTKKKLEEAQLANLYNEIKNRKLHSIVNDSSRWLKNGSIRPPDQASDYTRPKNESIGVKNFFDNERTEVKVNTRIKTDVKIRITLIKLGITSQDSLQIVETEKLKKYELLANKFAIIHKCCIKIIPYVMTWNDVVKRLQIPMNVEAGAPMHKKPTHPLKQVDNEEDGVKTEFRKSLLPLILDSIITAEEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJT5</accession>
    <name>A0A4Q9LJT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SWI/SNF2-like chromatin-remodeling complex ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_2264p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002264">
        <property type="protein sequence ID" value="TBU08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2264p0010"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="85"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="377"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="686"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="867" mass="102588" checksum="D95DBCE7C2B9D074" modified="2019-07-31" version="1">MNENLIKKYREFIGENDFFDSLIGNRTVSKHKKTKKEKEHRRVSKEEADTDISPFVDEAYTFRTTPAYISGTLREYQLEGVNWLINMNYNSINCILADEMGLGKTLQTITFLGYLKFFKKISNPHLLIVPKSILHNWKSEFTKFLPEFRILVFHTSKKELKVNTSSLNEMDYDVCITTYEMCLLAKNSLKNISWNYIVIDEAHRIKNEKSMLSQIVRIFNCEHRLLLTGTPLQNNIHELWALLNFLVPELFNDSDHFEESVMRIDQENEDSVEKLRNVLQVFFLRREKREVEQTLLPKKIVNLYPRLTQMQRDWYKMILERDLSPILGKRDSKSMLMNIVCQLRKCCNHPYLFDGAEPGPPFTTDEHLVENCGKMVILDKLLKNLKTKESRILIFSQMSRMLDILEDYCIFREFDYCRIDGSTSTDDRTAAIDEFNSDGSKKFVFLLTTRAGGLGINLATADIVIIYDSDWNPQMDLQAQDRAHRIGQKKQVFVYRFITEKTIEERIIQRSLQKLKLDEVLVQQSSKTTATINQKELLEIIASGVENIYENDQDTKTGEVIQFNDKNIEDIIKEGEEKTKELSSKLEGINFLESKMANTDLYEWEGEDYSVKNKLENYIGSKIPRKGARTVSLLKKVKPRIYNLPEYQFFPKKIYDLQEKEIKSYDQDEPGLTDEELTLKEQLYSEGFPDWTKKDYYNFIKAMEISGKDNLEGITQHFFFKDPETVKRYYKVFWERIKELSDYEKILQQLNKAEEKSNRNKQIKNILDFKFSKGIHHIKLQYAANTRSKFYTENIDKFLLYSYYRNFNDSNVFEKILWEIRRTDMFNMDYYIKTRIAGDLMRRINVLTTNLLKYESLDDIKSEYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKZ1</accession>
    <name>A0A4Q9LKZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2292p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002292">
        <property type="protein sequence ID" value="TBU08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2292p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="307" mass="34490" checksum="8FC6E3CFE3E4E9A7" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKTKAANDADEVKKSDSEVQKCKLHPPAISLPPSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSAWEPSYDMTSPCTLAIPEGNRLMALRMIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKMKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM33</accession>
    <name>A0A4Q9LM33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PROCN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2159p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002159">
        <property type="protein sequence ID" value="TBU09344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LM33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2159p0010"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROCN" evidence="2">
        <location>
            <begin position="300"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="2">
        <location>
            <begin position="579"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="2">
        <location>
            <begin position="733"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136576" checksum="5CD602B3320DB9B3" modified="2019-07-31" version="1" fragment="single">GVNNSTIKQYPNPTLTLKTCINNNTSYKLQGHNFLRSKNSLLTVRKLNLLIPNTPYTKNPSLSTYNSLPIQTINTLTHSYHKIVYPYLYNNILPNTNIPLEKIHPQLTHNTCNYNYNKDNYNCNNKDNYKDNKDNYNCNDKEFEQENKRIKYNNNTSSDKEIKYLQQHKRINRNNIKEEINRECINRECINRNNIKEEINRECINREEIKEEINSECINRECRNREEINRECINREEIKTRNPPNTSNTSNSTNTSNSLNTSNSSNTSNISNIPSETPLLKHLYTYTTNPLITPISLSLIKHTLKNKKGKKSNKKTIKQILKTKYFHTTTLDWLEVSLSTLQQSKKILTNILRIKNISYLCIDNNFNIKPTRTLTTKERKKSRLGSSFHLLREILKLLKHVTDLFTLYRSNTITWLTLTCNIYYVFSHVGTLTGIYRYKYKAMRQIRRCKYLNAIIKGMVGGSVLGGVSSSVVGGGDSSSVVGGGDSSSKQHPFNDSNSKQHPVNNNTNNYHPFNDSTNNYHPVNNTNNYNPVNTTPINYHPVNNNTNNYHPVNTTPINYNPVNTTPINYNPLNTTTPSLWSPLWRVWLAFLRGHTSLLSTYLSNLSLRMINGRKYNKKKITKQRIESNYDIILRNSIRDTVRRYVPPDVYTECVKSVLSYYSEGWRCYKSNIGFCLGLGVDSIVSNPSLTLNKCINNYDNSKCINNSITPINNPVIDTHLNNSITPINNPVIDTHLNNTITSLNNSITSSNNPLYSIINHFLSLKAINYYNSTVKTYKRILNNKKVDKTDIKKNKGKITRLYLKKEFNRQKMYLEKGPFITEEEGVKIYKLMYEYVRGVNNSRGVEGVSDTRGLEGVSDSRGVGGVSVSSSVLEGVNNSRGVEGVNNSRGVEGVNNSRGVEGVNNSSSVLEGVRCSKEEDVSNSSNKQQGVNISTNKQHLFTDPNTNTNTNTTTNTNTNIPFPTFNTDTDYKLLSLTLSYIKNNYPLNNKDQLFIQECINTPVNTLSLIKKSFLLKRTFTDIKIQLTDTLTPFYTIDSIDLITDTFLEYYLWYKGCYYIPVYYKPSDSEIMGVTVQRYSNTISSIVYGNNVSGSECGSGSGKEYINNLSKDNCINNLSKDNCINNLSTDKCINNLSRDKCINNECINNLSRDKCINNLSRDKSINSECINNLSRDKCINNLSRDKSINSECINNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM38</accession>
    <name>A0A4Q9LM38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2200p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002200">
        <property type="protein sequence ID" value="TBU08966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2200p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15652" checksum="D01D068E366DC663" modified="2019-07-31" version="1">MMTRDGIATKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGRESGLNAEESWERASMGVIMRSEVHEEPTPPLKEEKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNP7</accession>
    <name>A0A4Q9LNP7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2116p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002116">
        <property type="protein sequence ID" value="TBU09787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNP7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2116p0010"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000030">
        <property type="entry name" value="30S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="484" mass="55727" checksum="1CC6DBE4B936DCA5" modified="2019-07-31" version="1" fragment="single">MKQPVIPIADEIVNALIGCSCHLGGTNCTNYLRKYIFGQRPDDKIHVIDIPKMWKKLILAARMFVAVENPKNVIVVSNKNFGRRAVLKFCETTGATPITGRFIPGSFTNQEIKGVREPRLVLVSDPFADKQTVAENSYINTPCIAFTNTDNEISFVDVAIPMNNRSPLAIGAGFFILSRLIGYMQGKISLIEDINNQIELFFYRDPVELEMLVEENKNEESAGVKMQDDISPVDDESKKKSIFILKNIKVQVCYDEATRKEKPRSAWKENIESKIYKLVLSKDLLEKARKQEKLSTSETKSLNKIMREFNLNLSSVTDLSEALVKKNESLNVYKKKITMHESTKQFRKENRMFELFRGRFYRGLSERVEIEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTKFPSLDEIVSIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQVDWFYCGLTYLIPKGIPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNU1</accession>
    <name>A0A4Q9LNU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit delta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2074p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002074">
        <property type="protein sequence ID" value="TBU10004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNU1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2074p0010"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="382"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="848" mass="93440" checksum="6D89AE90787EF777" modified="2019-07-31" version="1">MHTKQSSRTSKILTSNIQAASSLSSYLSTSLGPSSHTKLISTTPPTITNDGATILKSLKFKHPIFPLLTNLSTSQDSNCGDGTTSIVVLTGYILDVLYPLTTDVHPTYISSAIQLAIQYVQHTIHTHSIHISTDPHTTTLLHSRSKIEVDNSKEGSKLDSSKLDSKLDSNKDSYKDNNIRDNIRDNNKDNNKDSNKDSYKDNNIRDNNQYTNNNNNTNNNNNNNNNNNNIRDNNKYTKDNNIRDNNKYTKDNNNNNNNNNNNNPNTTTYFSLGNKILVNAINTSLSSKITPSSILTPIAINSIIKTKGNIKNINIIKKEGGTFEDIKMYDSLILKYKVTRGESIRECIREGGMLECGSNSSKDSSKDSSKDSSKDTSKDSSKSSNNSISNSKDSNKDSSNTNNQYNNQHNNTSTNNTSTHNNQHTTTHNNNNIIRSLAVITFPLSLPKPYTDSKVSITTSNQMDTLIKEEHLYLKNICNKILEKGVNIIIIQKSILKESINDICKFYMERKGCWVVSDVERQDIERICMCLGVEGVSDVEYIEGNVREVEVEVCEGYIRIGGCGGVCGGEGVSGGEGSRECGVSGEGSTSISRDNSSKDIRDNSRDIKDISVSSIEDGVSIEDTNNPTNTTIHPSNNPTTNNNPTTNNNICSILLTGGKDVLEECHRNIIDALSVSKCLYDLPFVVFGGGWIEEVIGEVLIKEGNNIGGSKGLCLVEISKAFKRIVLSIRSSGDIVFMPVKVCMGYICMALECAGVIMRIDDILPGRRVLVIGDSTNNKVGITKSLKVLKYGSKGVNMRVWYGSKGVNMKVWYGSKGVNRYKGVNMRYEGMVVRVLINSGSKGVNRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP97</accession>
    <name>A0A4Q9LP97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0268p0010</name>
        <name evidence="11" type="ORF">CWI38_1921p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000268">
        <property type="protein sequence ID" value="TBU03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001921">
        <property type="protein sequence ID" value="TBU10239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP97"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0268p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1921p0020"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="377" mass="42044" checksum="1613FC5441FB6FC6" modified="2019-07-31" version="1">MTATEEVTALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPKHQGVMVGMGQKDSYVGDEAQAKRGVLTLKYPIEHGIVDNWDDMEKIWHHTFYNELRVAPEEHPVLMTEAPLNPKANREKMTQIMFETFNSPCFYVSIQAVLSLYASGRTTGIVVDSGDGVTHTVPIYEGYSMPHAVLRIDLAGRDLTDYLTRILTERGYTFTTTAEKEIVRDIKEKVCYVAQDFDKEMSEYAVSKGADMNFELPDGQVMVIGSERFRAPEPLFKPSLTGIECSGIHETCYNSIMKCDVDIRRELYSNIVLSGGTTMYPGLCERITKEMGSFAPSSMKVKVISPPERKYSVWIGGSILASLSTFQQMWITKAEYEEDGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN4</accession>
    <name>A0A4Q9LPN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAR-17a/AIG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0306p0040</name>
        <name evidence="7" type="ORF">CWI38_1756p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000306">
        <property type="protein sequence ID" value="TBU03371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001756">
        <property type="protein sequence ID" value="TBU10443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0306p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1756p0010"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU03371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="220" mass="25670" checksum="C16960DC9A7614B6" modified="2019-07-31" version="1">MIDFIVRIFGLFLCFYGVSERTMPLEMASALRMSFGGRQQFLTIIGLNATILTLIFGLVIRYARLDKNGNIFKYVSSFHTFLLSLIIPVEMTITILFWVLYLKDPTLLISKEFYERNIKIRLFSNLCMHLFPFILLIIEIIDTNIKRSNIHLIAIIIFSITYYFWVSFIASMNKRWPYPLLDGLNGIGRLLIFTAVTLLTVSFYETIMYLAGKTKKLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPR4</accession>
    <name>A0A4Q9LPR4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1768p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001768">
        <property type="protein sequence ID" value="TBU10428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1768p0020"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="65536" checksum="6D90B43FF0676646" modified="2019-07-31" version="1" fragment="single">PLSRKLNEEYAKVTIQTEDASYSTNHLLFIDDLKLLDKDGTTLEKMTEEVKMFMKNIGLEINREKSATNDSCCENTATLLEGIGVYKYLGIIEDSRGIPTRKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLINYHIGVLRLEPGDFSKLDDAVRAVLVNNKIHLRPGCKKRLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENDNKTHLALIKDFLQVKYGMAEKVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVGVNYSSRCLKKGSVRPRDETVFFYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVPLCSRNSYFEYAEIRVDTRIKTDVKIRNNRPDIFVLEKIRNKITLIEVGISSQDSFQIVETEKLRKYDLLANELGLIYKFSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGLEASLSVILGAEIHKQPTPPLKEVKNEEDSVKQVNSKNILPHILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQD5</accession>
    <name>A0A4Q9LQD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair and recombination protein Rad51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1679p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001679">
        <property type="protein sequence ID" value="TBU10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQD5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1679p0020"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="103"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="45169" checksum="0A0AE558A2E1B0C2" modified="2019-07-31" version="1">MIETEQTILSEQMKDSEEETLHPIDDLSNFGIASQDILKLKQAGICTLKGLTMHTRRNLIKIKGMSETKVDKMKEAVHKFFDSSLTPTTSFMTASQFNCRREQVLKISTGSSDFDTLLNGGIQTMAITEVFGEFRTGKTQLSHTLCVTVQLLNSTYKAAFIDTEGTFRPERLKEIAIRYDLNPEQVLENVIYARAHNSEHQNDLLIHLTNKFIEEPNKFKLLIVDSVISLFRTDFVGRGELGERQQKLNTFLSRLLRISEEYNLAVFITNQMMADPSATLSFVADPKKPIGGHVLAHASTTRIYLRKGRGETRVAKIYDSPDVPEAEAVYAITVGGIDNAVEYRSYGYRGMDVTVGGIDNAVEYSGYGYKGIDVIEGGVKYKSYGYRGMDVIEGGVKDMMGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ8</accession>
    <name>A0A4Q9LQJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0738p0010</name>
        <name evidence="1" type="ORF">CWI38_1537p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001537">
        <property type="protein sequence ID" value="TBU10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000738">
        <property type="protein sequence ID" value="TBU12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0738p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1537p0020"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="24380" checksum="171E31B59E2CA2BA" modified="2019-07-31" version="1">MLKDEDVKKISESKTNEINRLKQNIVGADGLIRNSRVDTERYRDARNEENRIHLAKNKQSTMAHMELIQKYNTIHRSREMYRNVSDTRRAFITRTNSLINRWSEHFRELRNERGDQADTDNVFDELEDMDNEISSELIKNAGENYIKELTHLLRENEKKRKCLKNGIQQRLTVFEKKILQRIYGFKEENGRWRKRHNSESTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM5</accession>
    <name>A0A4Q9LQM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1706p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001706">
        <property type="protein sequence ID" value="TBU10517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1706p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="546" mass="65276" checksum="E7D1E33AA8092005" modified="2019-07-31" version="1">MILFFLYYYRALFMLENNTNEKENFDLDLSLPKLKRENMNEYNTFFASISQSIDVVTANILTNYNRQVYHRNYFACYLIPLIHFNIVKSKYTVDKEHLECLIVFLEIMYFFKYKEYFGIINTVSNENYFRTSIHFFMEVSHLSEMIFNLYLHSDLRQRTCFFLHFKENIEDFKNTDLTAFDTIDKFIILMTKICEKIGLVSTNWSSIFDRDVEIIVCRIFSLVFNVVISKDFDAISFDEEFCTKVIEDSDKINDVIISYRKLDLTRSFNDYLAHISKISYDRLMAGFINLHPRIILNKHQHIVGINIREMKTEKAINIADTLKNFRDVINQPMHVCKNPIYEKFDLDIIEIICQSIYVNCHLLFCEIEYARVFGFCINKYKRLGYHYMKYSNGDQHTLTYNSTMVLCVEYCIYAEIRNINIFESDCLMFDNIDLLRNLIIDTMNQNSNQVTKLSPENFFPAFVTRNFLFFHYYSNCELIFQFCIKDTSSRIFIERGHFFRVNTIIIGYLLSFCQKEIFSEEFFRKNVQVILEIDNRIRSANLSQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQW6</accession>
    <name>A0A4Q9LQW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1640p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001640">
        <property type="protein sequence ID" value="TBU10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1640p0010"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="310" mass="36874" checksum="019EF2F509BC32D4" modified="2019-07-31" version="1">MEFESSDNFSAEEVNAQKEPNLNINTEAFDVYKLYLDRVVSLPFIKTNQDTLKSDQKQPNIFFKNCKYINYEVLQNDYFENARRCYSTFDKEFYPKYFGKNMFEKYHFYKICVTYMENRIKKLVSYVKSEPFLQFENFNAFLKKFSPHFNAENVTSCGPSFIPISVNYVGGRSQSDEKIFLFDIDDVFEKIVERILDGNHTKLSTVSSHIKFKQELKEVLKKICFANFIDRSAQYIYKEINLLDFFNSVIHIKSINRYTAILKPEESAYKSVEEFLGTSPSNNYFFDNKSKNIDMARERCWNVFEVEIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC5</accession>
    <name>A0A4Q9LRC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1960p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001960">
        <property type="protein sequence ID" value="TBU10181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1960p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="13316" checksum="3C87410FABC1CDBA" modified="2019-07-31" version="1" fragment="single">FNQLQSTNTQEGVNTNTATPTVTPFNQLQSTNTQEGVNTNTATPTVTPFNPIFNNQPNNISNTTQIFSNLNTDTTNIFKKEINSTPLKNETENTVFKPQNAFSKFMSGKSNLFKKYEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ5</accession>
    <name>A0A4Q9LRQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1471p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001471">
        <property type="protein sequence ID" value="TBU10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1471p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="41414" checksum="6240DDDDD7D5AFF2" modified="2019-07-31" version="1">MKKGSEVQKNMISLIFYILNFKMIEIWLSSIEQIPVLDFILSLSVGFCEAVILEITEINSSFIDFLNECSFFKNVKKILIFGGSVSNDFNLNSVHLPNLETLSLFMKNDIIESDKFTKPLKMATEAEIKDSKISPEETPIDNKKEKHSAESDKYSANTSISVFHFMGNKVLLPKNFLTLINVMKNLETLKIEVCDLQFLPIFTDICDVPKKVLKSLIIIVASEFSTMYLYFIRSFLVLESLILKSKVLSKIRYDFSDVPYKEYKFTCIALTGIDILIENVIFLKNLSHLTELIFNNCPFIERSYLSLTKKNFSGLKLLVCNIFFEDSRTFVDYSKDITMFLSTEFSGDVLHVQNVFNHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ9</accession>
    <name>A0A4Q9LRQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1314p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001314">
        <property type="protein sequence ID" value="TBU11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1314p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23044" checksum="0E55D85D7130BD3D" modified="2019-07-31" version="1">MDIKILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITFQESLQIVITNKTNRLGLIYKCSVEIIPCVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFVRRRGLESGLNAEESWERASMGVIMRSEMHEEPTPPLKEETREEDGGTTIEEPISNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS6</accession>
    <name>A0A4Q9LRS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1304p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001304">
        <property type="protein sequence ID" value="TBU11248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1304p0020"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21124" checksum="A52E96BBF323D0FC" modified="2019-07-31" version="1">MKRIDLRNPNKNVQKKNQTLMKLLDEQPNLFSISPVHVLVISLIFIGTVFLLHLYARFGGKSGGMQLFISFCVFVGSVPFLVVSCDNERILQANSVPGMASKIIKEFEKDFKEIAETDIFEKIVDKINASNSALFDIGDYINDFSIFKFNSENITYGRFFEIMEKKKQKEVSAILSKLEISMHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS70</accession>
    <name>A0A4Q9LS70_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0921p0010</name>
        <name evidence="4" type="ORF">CWI38_1440p0010</name>
        <name evidence="3" type="ORF">CWI38_1463p0010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000921">
        <property type="protein sequence ID" value="TBU00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001463">
        <property type="protein sequence ID" value="TBU10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001440">
        <property type="protein sequence ID" value="TBU10996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0921p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1440p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1463p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19436" checksum="4309B07F46480F64" modified="2019-07-31" version="1">MFDIFCRKKSPKQLFREISISLRKQKLYSLKLCNEMTSLYSSLMKSIQNKNIFETQRFSRKIVILEQRIQRNDKICEKLEELHDIVNESSVIASGTLSEVSKVMEKCFKEIKNENTDMFEYNKKRLDVIRNDTDENEEEEVVKKAEEIVVKAKAKISEQQDRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA2</accession>
    <name>A0A4Q9LSA2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1356p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001356">
        <property type="protein sequence ID" value="TBU11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1356p0010"/>
    <dbReference type="OrthoDB" id="2191697at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="23989" checksum="CC04AB9C4C27DC68" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEMTLTKRTNYSDAHIKIRIIKALGAIKPVGIHKHFYLVKILRNMKKPNIITADNIWTFLNTTFPVEKFDEEDFDRIFDNKMSFDKNFEPYVENKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB5</accession>
    <name>A0A4Q9LSB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1252p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001252">
        <property type="protein sequence ID" value="TBU11354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1252p0010"/>
    <dbReference type="OrthoDB" id="2197364at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="46902" checksum="67722FE07A43466B" modified="2019-07-31" version="1" fragment="single">NFIYHEEIIELFKNTFKLKGTNLYRWLIFLKENDFLQSLFERLEKGEEVYNTCRIILSVLNVSCMLLGNKILRIEEWKNVGFLNEISDKSMFLIELFLMQRSYRILNVLYNILALILTYKKNMKICVICMVYQKKLEQKELNFLTNLESSISFFEIMLMIKMLLSKRYTLIRVIYSLKVHVLLVEYFFKHSGHSGYHMCFFNFVRYFFMFPVGLNAKILYDILFQCCFIERIELWTREVLAKEFEKFPAVPPMTSYLIKFYELLFDLKNECEMITKNMPKTDSTKNIEDLYDNNSDTNTDYENERNLDCYVFFDSKLSFLDSEEWISLRELYFDRLNRKLKLSYSDLKEMDCYIEDCIQEPFIRYIFRVLYNDFPSCSLFDENLRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC5</accession>
    <name>A0A4Q9LSC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1246p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001246">
        <property type="protein sequence ID" value="TBU11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1246p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="646" mass="69687" checksum="8F71CFF4FE349875" modified="2019-07-31" version="1">MLEIECRKKCRRSSSESDCFSDSKSSCSSSSKSCISWSDHHEDRRQNSFVNCDSRRKCEPCFPPPKKCFLPKPHKSHKPSPPCPPKPSPPCPPKPCPPCPPYPECPPCPPCPPCPPCPPIPACPTCPPIPACPPCPRCPACPPIPACPPIPACPPIPECPPCPPYPECPPCPPWPCPRPPRPSPRPCPPWPCPPWPCPPWPCPRPPRPSPRPSPRPSPRPSPPCPQWPCPPWPCPPWPCPPRPSPRPSPPCPQKPCRVLRTIDGIIDCAKAKSKCAVSEASCRLQEHIVQIVLRGSGKIVHKINEEFDDVVDCLKFKLSNEAVAITSGALTCGNCNSGAKFDKKKGDSGHESPDETDAKVLNIVKRNSKILKNGIRNIINAESAKLTSDLKDDLAKMSSSEKEEALKSDGYKNIISSAVKNTLSNITASTNVLFENVIQNEKAELTRLYENSAAYNNIRGNLRDKPENPGNGTGNGTGNGTGNGTGNGTGNGTGNGTGNGTGNGTGNGTGGGGGSGNQGNNAFPNSSATAKGCSGALTCAKIIPGHRHAVIGLIESLRRKILCKIDHVIRCEIGQIKCAFKIYKFFLDRKLDRIIWKAGHEIKESVKDAFEEYCCKVRLAPPSPRFEIQDTKEENSPAFEKLADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ8</accession>
    <name>A0A4Q9LSJ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1699p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001699">
        <property type="protein sequence ID" value="TBU10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1699p0010"/>
    <dbReference type="OrthoDB" id="2189986at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="91056" checksum="C08042EFA1913626" modified="2019-07-31" version="1" fragment="single">MVNIPGIKPKQHHIHIVDATDCPDICRIKKIINNLKDSNCIIDIINALLHSNRKIRITALKRLLYLKYEIIYFETNEELSLNNKEINEAPCIINNIIPEDKEFIINKEVNKSQSIISNMTLETNEEYLNKNNETDFNKYLLNEFQINNIIFYMLDDPCHFIREISLENIKFDLNFKKTNNKISNTSKEMLKIDKRISKTNNEILITGSEMLKTNSDENKIFDSNLKKLLKTTFSNNELLNKILALSYDNNTNIRLISIKKLSEGSFFVKNFNSKIFLRFCSLFTDTSVNVRKKVSKYMRKIQITNRNDITNILNKQPSNDKIIKDMKFYNSNGAIIHGLEDENTEVRLNTIKALYNFTLDLDLTTKIFYLILDMLNDDIEEVRRVSSYILVLISKKYKLIFNFQDLKILQGCLNEKCCIIRGNVFRVISHLQYNEGCLDAMEFIIKGINEFGVEIINCKNIDKIGNEIENIVNGDITSELISIKQTNETNKNNEIIKNCKSNEINTNNEIIKNCKFNEINRTEINNEINRENYNLLFDCLKNFVKNNFDFIKENINNVFDFKNNIYREMCLEDKEYLGRLCIIYYLNLESKIDILWYMKNHFRYLEILKFKYEICYEKNENKILYDEINIKVYSLLVKRFIFIIKNIEYFYRMNKGIEEDELTDINGNKFDKEMECIDEEKVFINEETIDENKFIKEELIKEKESLIETETIDREKEYIDIETESIDRETESIDRETEFIKETESIIEKESLIETESIDRETESIDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY1</accession>
    <name>A0A4Q9LSY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1234p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001234">
        <property type="protein sequence ID" value="TBU11387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1234p0010"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="489" mass="56958" checksum="AA17A938AE253C68" modified="2019-07-31" version="1">MSVSYFHTYKSHIKGRWLNKPLQEALSSEFTHRPPSYYTNAIISQAITINDQPTNPDKILSSNDILYHTVHIHEPLPKQLKIIKIESEYLVLEKPFGVPCHPTTEYFHCSVSQSLKQFVYFEIFNNSEFLNKEFQSFNEKRNYLIDKNKNKTNDSESSTDNTNQNLYMKENYLIETNENNIKNSFSSTDNTNQNFNDKENYSINTKDIKTNDSFASTDNTNQNFNTKENYSIYTKDINTNNSESLMNETDHIFLEKKDIKINNSESSINNTNQKFLEKDFPLLLNFNFATFNPKITLSCINRLDLPVSGILIIAFLNSQKYHKIIKNSSTKKFYVALVKGNFPNKISVNKKLKFVKGKKSFVDEQGKESFTDFYGLKRNKEYSLIECMPVTGRPHQIRAHLSSIGFPIINDIKYGYHQIPNESNDISFGCFTPLNHTQTHSKYRFAINNCKGIKSKSFRNYNEYICLHAYKYVFNGNTYECELPEWANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT16</accession>
    <name>A0A4Q9LT16_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1075p0010</name>
        <name evidence="8" type="ORF">CWI38_1283p0040</name>
        <name evidence="7" type="ORF">CWI38_1319p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001075">
        <property type="protein sequence ID" value="TBU00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001319">
        <property type="protein sequence ID" value="TBU11215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001283">
        <property type="protein sequence ID" value="TBU11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT16"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1075p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1283p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1319p0040"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="97" mass="11384" checksum="49962559380ED58A" modified="2019-07-31" version="1">MTKNIKLTSYDGHEFIVPEKIAFQSSTLKFIFSENHPFVEAKCRSAVLPIHSRLLKRVVDFLNFQYNYNNHRTKPSDFEMRDEETLELLDVSAYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT34</accession>
    <name>A0A4Q9LT34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1275p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001275">
        <property type="protein sequence ID" value="TBU11306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1275p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="29287" checksum="E0D106C339FE1183" modified="2019-07-31" version="1">MRSKGHKNQSKTKKKKNGIPNPYNRIKEESHLTEDLDLKCIVSICQDNDLEDLKIFFSRSYIYLDYKKLLKLFPKHMSVSKIETLDSEYFISSIFGFCNYLDIKTNIKNNLVTEIDAILDRLEADHKFEQNMVRYVVSERILNLPINIFMENLKNIEIENYIYIYISKLFKIEEENKNEVFSTFKEFKKDDLICFPDKAEEIFLIKYSLISKVINISNVNFRISVLDHKSMKKYFYKIFEETINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT59</accession>
    <name>A0A4Q9LT59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1581p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001581">
        <property type="protein sequence ID" value="TBU10730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1581p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15812" checksum="5365203423A74082" modified="2019-07-31" version="1" fragment="single">YVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLRKTVEMIPFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPRIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT63</accession>
    <name>A0A4Q9LT63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1260p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001260">
        <property type="protein sequence ID" value="TBU11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1260p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="390" mass="45297" checksum="1FD31B2A30D2822A" modified="2019-07-31" version="1">MSYLCKIFFPITLSIFSFHISRFGYCSIHRDSVIKYTQSNRTDASDFDPLICPNPPFNTKYASSVSHLLPNETDFEFCDHSGNIYNELPLDGCCEHPDNPIFESYKENRDRPEERSYDEAYTLSEDLMPLSYDEKNNFCGKTSSNTINTESEKNDFLPSEEGKIEAGEVPDFECGSQYVKSIFETPVKNPEHKNEDQIFGSRDQLYESISGIYDRKSDNGSEDSSYESCIQFEEHSIESYDEDINKKGDNLLYEAWCQSDEGILEMNDKNSDNGSEDLSLENYRSEIESKNSISDSLKEFLKNHITNQGEPHTDFILNFLLEIFSNAEIKTILTEIIARKKIEIVRDKCTLIQNFFETLKTTDEDQWDEKFAKHKPQYKELKRQYDQLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT72</accession>
    <name>A0A4Q9LT72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1256p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001256">
        <property type="protein sequence ID" value="TBU11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1256p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="26350" checksum="8C06E91498B182B9" modified="2019-07-31" version="1" fragment="single">MITNESSTHYKTFKAKLLTLNGILSKILPLDVLNMHPFDYFTEYTLNISDILDSLIIKAQNDLKKYETQNLELKEEINEMKKYLEKGNLNECSSSIESKEESENIFIAQAFLQNEKQSLSFEVEKVKKEINFLLESVISLETELGRQPHFRDFELTVTENIFLTRDLYLENNFSFKEIKIYDCKNLLERKEIIKMKENYSNKSNINNKEINTFEMIKNINENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD3</accession>
    <name>A0A4Q9LTD3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_2092p0010</name>
        <name evidence="5" type="ORF">CWI38_1001p0010</name>
        <name evidence="4" type="ORF">CWI38_1375p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002092">
        <property type="protein sequence ID" value="TBT97755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001375">
        <property type="protein sequence ID" value="TBU11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001001">
        <property type="protein sequence ID" value="TBU11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2092p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1001p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1375p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT97755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="108" mass="12593" checksum="EE7293BE72143921" modified="2019-07-31" version="1">MKPKVFLTAKDEKENKDTKIVSNKAYETANHIAKTYRDILMDMSGRNDELQVLLRKSSELDIKTSALAKRSGKKRKEMVYKYYKYVIYLVFIILVIFAFSGIYALGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH3</accession>
    <name>A0A4Q9LTH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA/rRNA cytosine-C5-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1123p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001123">
        <property type="protein sequence ID" value="TBU11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1123p0020"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="34093" checksum="99AD13EBF0CA1201" modified="2019-07-31" version="1">MLDSYDPKLKEKLENLFNKKELPIYIQESHKQRPLILRSNPLKIKRKDLARLLISRNTNIDPLEITPYTLIVYNSSVPLGATPEYLSGYYCIQGASSLLPVINMDIQLNHTVIDMCAAPGLKSTHISSLLQNTGVLFCYEINNERCISLRSNLYRMGVTNSLIINSCATNISIKADRILLDAPCSCTGVVSKDMGVINKPLNILVLTSLQKRLILKGFDSLKAKGILVYSTCSVLTEENEDVVEYLLRKRKNAVLQVVSGVGVDGFVSFRGKNYHGNMKYCKRVYPHVHNMDGFFIAKIFKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU06</accession>
    <name>A0A4Q9LU06_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1092p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001092">
        <property type="protein sequence ID" value="TBU11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1092p0010"/>
    <dbReference type="OrthoDB" id="2192635at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="17188" checksum="52A6A6569315FB2D" modified="2019-07-31" version="1" fragment="single">MLYFTDAESHATNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIGLEINKEKSATNDPCCEDTATLLEGIGVYKYLGIIEDSRGIPTSKSFEEVQSKLIARVERLCRTRLNARNLFQAINQHAISLLNYHIGVLRLEPADFSKLDDAVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU50</accession>
    <name>A0A4Q9LU50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0914p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000914">
        <property type="protein sequence ID" value="TBU12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0914p0040"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45574" checksum="04BEAF5534BC1571" modified="2019-07-31" version="1">MILRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYKARKNELVSVSDSSRWLKKENIRPRDEAVFCYIQDRNVFWRADNVCQHCGKSGKTVDHLATRYENEVVRCLHLLLLNRYNFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANDVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESRLNAEESWERASMGVIMRSEMHEELKPYLKEEKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKVVEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU79</accession>
    <name>A0A4Q9LU79_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0853p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000853">
        <property type="protein sequence ID" value="TBU12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0853p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="73121" checksum="45F011BE9334455C" modified="2019-07-31" version="1">MVFGILIYKPKSIYNIQNENVKVNMEYKRVIFLFFCVLNIRCAIKDERIKTFDEIRFEMLQDPFIFYISTYYYDCIRIMVYKKMIDDLFKSFPISEINEVECDLNFFKEHYLTDPIGSDITLYKFFKYFKPKTWEIWSEMFKYRVIYVIFDFFRDYLSEYSVLFNEHPLFRAKTMSFMENSYLKKLEGKGYIKSYGVKELEILIKINTETCDDVTTVLCTDQNTNDISIEDSQVPESNAQSINTPPENPIFKNKTEADSGILPQKQDQTELFSDETTLREISHQNISNPLISSSADVACDNAYKCILLDSLETLFFEVIGFFKKNILHNNHKLLYNFDYTSYKNSNLFETHKNLLKQDTNAKSKSIIFAFFYKKMYGDYQSYLNTMLSHLKEVSSNNFENLTYYFHKMLNSPVYKIGITKDLYYLAIDSKFIPQMNYDEKVLVFDLDDTLFPTTFYLSNTKDFLSSNKNSDFDDSDYVSKLDVKETIEELKTIKLIDHFKKRKKLRWYLNNLPYKKICLTNASKPHAEFALKALDISECFEFVLYKGIDMKKECMKPYKYPFKVVEILLGCDPSNIYFYDDISANCVTADQRNWNAFLINENLIETIEDSLNSRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC7</accession>
    <name>A0A4Q9LUC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1029p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001029">
        <property type="protein sequence ID" value="TBU11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1029p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="699" mass="83750" checksum="63289B464DC39748" modified="2019-07-31" version="1">MFSFHYCLNLIFFVFIRNSKQKDIIFYVAKENKEQISGLNNHESKNECICRIRRKFDDESTEADAVEQIFIRDTNIEYNQYTLYNIEKIEFKFETLDTINEDNQNIEIFLCHHVKKSEFLIFHRFIVSYNSQEESMTIVKFYNILYFLEYLRVKYEDILQKCLEKILFSLAEAQEIRDLDMDKVSSHFPKQELFSIEFCKILFQVYFENFFSKGKNIYSEFFKVEVETFEFTYEKLYTEDSMQCLIINEKIASFIAQNVDINLVNKNLFILLLNTFDVKYLHIENMKDVALEGYCFILENLKKNIDEIVFNNVSISDQLIRSLERNLNFRNLKKIFSKGPKFIFFTGIVFKDEDLPTNSNVSENLNTCKRIIMNSKKGKIMNWLFPPKNVIPSRINVERKADNLYLSLFNLELSEEKIKIFDSLDLIYDNWRLNCYYELNGSFNYVFITFENFKLKNFRISDSVLPENIRKIHLSIKESEIYMENEFKIQKCQHFYKLIKLMVNLKEGHLSYCNYIELRFFKNQKIEVKELYIWDLNTEYFIGVPLKNSPLKSLSCCLFEKYNFSRIKKLYMMEFSIQASDSEAFGDLFYLKELTLQNIVFKNISFSQLFCSDKEYKIERLSFTKIHIDESALKFISKLSQLQFLRLDGCDVHSKASSYITFSSLKHLHIVLWDSNDDQWKKFIQHILKEFGAERITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT9</accession>
    <name>A0A4Q9LUT9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0891p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000891">
        <property type="protein sequence ID" value="TBU12117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0891p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="284" mass="34425" checksum="A6572BC9D7954766" modified="2019-07-31" version="1">MIRDSSDEACELNYTEHLFSRNKEIEISRFELFYSFIIFFYITHEKITIDGFYTILYLLKYFKVQCDNKLRDVLKNIFVSLSRSNDITNHDVTKILFDFSKKEIFSHEFFKKIAEEFFNLFIPDIDYVSSLYLKEQDVLLQEKYYPLYTDNRSENILILLLNTFDLKYLHIQELEYKNLKTLYFFLKNLKKPIDEIIFYKIPIQDQLIISLNTNSNFASLKRMVFLESMKETNMKFSYNLLAVNEIIFYDQFYIYQEDKIVESLILKELNNIKDTIIYSKNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU3</accession>
    <name>A0A4Q9LUU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1248p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001248">
        <property type="protein sequence ID" value="TBU11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1248p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="49598" checksum="8688371FB30C74DD" modified="2019-07-31" version="1">MNEILFETIEFLKQLKNINKISIPYYLPNNINIIEKILELPNYMPATQISLTLTNEIIETLSLLPKEYLNSMTNKNLALHIDFPKNIDILFSKIYKTLNLENFIETLKIGCNENLNKNQAKILSMFKKIKDFSLFFRIIGDSPYYKLQEFDFVSNFNFMKKILIFNSTISLELFYFVFHSKTLKRVYFTQIDISEAMNSNFNFPNFNFCVEKFYLKLINRPFNRNLLEYLQCFKQLKFIEISSIAPQLRIHFDIHFHTTNDKLLEFFNDDKVDSNGFLYIKKLNMCQITFDSELLNGIFDKHWSLKNICELKLASTILYNKDMSFLSSLNLLKSIHFEKVKFVNCFFSDILSNYMLKNITVLYLDNIEFVKNDFIKISQLKNLELFSAYFGDHFSINRIKFVSLNDFLFHLETRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV53</accession>
    <name>A0A4Q9LV53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1171p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001171">
        <property type="protein sequence ID" value="TBU11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1171p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10104" checksum="8998B7962E70138A" modified="2019-07-31" version="1" fragment="single">MSLTVKLFKKTHMNGFNLMYVEDINVFISKKSICGFCISSDEYGFCSEENNILKICKGVHFFSRHQFICPNRNGNKKHFKLTTIMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV61</accession>
    <name>A0A4Q9LV61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion-degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0335p0010</name>
        <name evidence="7" type="ORF">CWI38_0182p0020</name>
        <name evidence="6" type="ORF">CWI38_1089p0010</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000335">
        <property type="protein sequence ID" value="TBU03205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001089">
        <property type="protein sequence ID" value="TBU11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV61"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0335p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1089p0010"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="4">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="234" mass="27065" checksum="86799C4661FC962B" modified="2019-07-31" version="1">MFFDFFRRNRDMYSWKLSPKTFEKGNKNNYGGKVLLPQLVLEDLVTSQILPPYTFEISHNDGVFLTHCGVLEFTSHHETITVPEWMYQQLCMDETLQVVIKYKFISVGTFVKLLPHSVNFLEIESPKIELEKCLRNYQVLTQGDEILCDFEEFGDIRFTVTSVGPAGDAIYIVDTDLSVDFQPPIGYAEKLENERTVMKYVEIVESENGIKYVKMKKLGLCLDFGEIETKTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA9</accession>
    <name>A0A4Q9LVA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0726p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000726">
        <property type="protein sequence ID" value="TBU12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0726p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020720141" evidence="1">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="396" mass="46107" checksum="BED168B44AD69DA5" modified="2019-07-31" version="1">MGTILLTLLIIQFGLLSDRKKTRGITKIFDNTRNQSATSIRKRPSTNSEDTIVKNFETLNTNLNILLCLSQVSNSKKNEYCKEEISGQNIRILSKIFSVEKTIYYSFTKNDMILKAEILNFVNTINEILNKKLYFFMCDLIVFSLINREDFRSKLQEGYILYASFLLEVIESQIEKIIENTSKSIKVPLNSTEKNDNTYKLEKGFLHIRLLVSKILFVMKDNNYSANVYFPQSLLSFFSSLTIQTLDVIESPLFKVFIDLLFPLNFYGGEKFAISSLNAIFDLITKLISKIPTKRTSILQTARNILIGYSDEKLVHFSFETLNFLLQKYKNEVIQDYFSRLNNKYKTLYCEENIPSKESDVKNIYKVLIQSQMCLYSYKVYLPEYSLYLVKDSVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ9</accession>
    <name>A0A4Q9LVJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0649p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000649">
        <property type="protein sequence ID" value="TBU12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0649p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7460" checksum="1D59369DDBFF7DC5" modified="2019-07-31" version="1">MYCTENKLGVSHSDGNFSIQDAKNSTQISNYENPPSLFFECLRKEEYLKMNHIKKQDQMMVAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL4</accession>
    <name>A0A4Q9LVL4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0182p0070</name>
        <name evidence="2" type="ORF">CWI38_0646p0030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000646">
        <property type="protein sequence ID" value="TBU12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0646p0030"/>
    <dbReference type="OrthoDB" id="2191528at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="46655" checksum="48A2F9710BD4DF9F" modified="2019-07-31" version="1">MNMWFSENSMSVSTPFLERSLKKMENICTEKKQTIKERECCAIFLMSLIPLKDSFKKYKNIKLFVRGYQKNENYRMNNIEYAISAKFKGNEFIINEVSKTKQVSFSCYHETCMTIFIICNKIVKCFYCKYNGCKLVRGVPLLLYEVDLFVKNKFYQIASEPSFEIRVKTINLKATNTNMPLHYNMNNEIVEYVKKHNFTYKIDEFEFDMDEIKCVFCFRSYETLENLIFHINHFHLNYYAIQSQNCIIVTLSVDKTKYDVEFCFFSKNYKRKHTTRIFSRYCYEYFESETMEKLGTKKNAIKWWNYLSDKKIAELVDISPSKILLMQNWNNFISDKRIEAKEINYFTCIKEFVLKNEATEDILDFLYILAGKSVISLEELVSIVNEKVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS9</accession>
    <name>A0A4Q9LVS9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0657p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000657">
        <property type="protein sequence ID" value="TBU12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0657p0020"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="393" mass="47150" checksum="AE6C8F79BF995847" modified="2019-07-31" version="1">MNSFRYKLPFIHYSIENFLNPVEYKKISDFYNKLNFSLKYTDLYKFYQTDELTENKNILFFKKKVLKICKEIEKHENIHTLDESEDIMAVNLKINGSEMIRNNLDIFGSFYRADNYLLCHDDCLENRKYAFSYYLEDYETGELALYDNTATTECKRIKVTKNLLIVFKVSKISFHEVLYCVKDGRKAFTGWFHEIQSSDYKSDNQSNINVLEGINYLDSSIFDLKCLEIQVKYKDYYVKNFTLEKNRDIFYTAKTHLNLPNLKEKDIKPILYNRKLIEMEFLDFFAIIFDKKILHLNDKNLKCEKHSFKIQKGDYILINDTLNNPKNIFYFVYFYNCETIKDNLSIVNNKGDISYNIPIDNDRLYFLPRNNISLFLERTQSTFNMIIFSYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT7</accession>
    <name>A0A4Q9LVT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0778p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000778">
        <property type="protein sequence ID" value="TBU12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0778p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020744507" evidence="2">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="19784" checksum="0199501A06B00933" modified="2019-07-31" version="1">MKFVVCFLTFFNFLAFGVLCASVGGSYKQPDDNPVLVSHKRVGTDYEPAIVSDSEKRELRVFEKTESECSETGQSKPGVSEKTVSIAVEKTESECSETLKPEEKGDGKSKIVSNGDVKHRAEEESDEKKVGCFGRCFGKKKNRVKANPKPSTLPPSNLSEEESNPVLKRRNSCDVIDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV1</accession>
    <name>A0A4Q9LVV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0609p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000609">
        <property type="protein sequence ID" value="TBU12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0609p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="27235" checksum="A54738F0DF393FB5" modified="2019-07-31" version="1">MFLFLLITNIFCTKYLIKLKDTDLYLTSTDNKNMSVGSKTEGKKVEFKKSTGKYNEILISDSDNTNNVFDLEGGAGKLILYPMHGGTNQRFTITKDYTGLFRIFSSTQKCLEYSESSNTLNMNSCSDNKNQLYELIGEEGEGGCNCDKMNDILENYGERLHSIQSQVGATHDLVSGMSISRSIGLPPSEISGVGGMGSLTGGLSNGVTGGSYSMSRGYGSPYHPTLLPISSSVRGLLVVVLEGVSDNRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW03</accession>
    <name>A0A4Q9LW03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0753p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000753">
        <property type="protein sequence ID" value="TBU12446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0753p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="735" mass="89136" checksum="1251B6FD7EBC3549" modified="2019-07-31" version="1">MFLCYSSQQNVIFYLVDHQNTDNSLNAKKMKYQYMCDIRRDMYAKTPGIEQNSQLFKRITNRNYIKYTLQDIEKIGIKFDIIDTFISKNTDREIFLCNHIQKFEFLYFLDFLMSYYLPKREMTINKFYSILYFLEYLRVGDDNNLHNSIKIILFSLSQSKDIEYFDLYKVSFHFSKQEIFSEEFLKIISQKYLEIFFAEIENFSSFFLEEMPTFHQYIYEMLYNGDDEDLWILNDENFSFIFQKVSENLNCKNLFILFLNTFNIKYLHIYNFKEKNENALYFFLQNIKKKIEEIVFYKLSIYDKLIISLNNFLKILNPKKIIFLDTYINQDLKITEHLIILNEYIFFDGCMIYDINKIKNENIILKIDSVKDIIMNSQQGEEETQIFSMKNTNRWYENTDEKVKNLYSNLFEMNQIEENVKIFESLNLTYEFCGFGCFYESNGDFHNISITLNKLKLKQFLIKDMQIEKNIKEIIIKDSEIDPNFLKDIFNITELESLTINNSELFIGNDIKLNNKSVKYFSFSPKNDKNCRYFFVLVAFMKNLREIYLKFYNEIVFISSYTQIMYIEELIVQKNEFLVYFIDYFEMRFNLNSKSILNSILDFNRVEVSLNQLFEKNLLKRIYKLTLEDMIVYKKDSGAFRNLSNLKNLKISEIYLSNIYFSELFCNSKEYKIEKLYFYEISIKEIDLEFISRLRKLKDLIFYACYIPKNASFYTKISFLNEIYLEIWYKKNSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA9</accession>
    <name>A0A4Q9LWA9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0683p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000683">
        <property type="protein sequence ID" value="TBU12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0683p0030"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF90">
        <property type="entry name" value="OS11G0565920 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="67646" checksum="0A22CE6BACD77E0F" modified="2019-07-31" version="1">MTNSEYLRHVKLFLPFLAVLYDEVDVFFDSNTKELTFIAKEQNRESFKYEMNFTDDTIIRITPEALNYMQQDDSDGKRELLGLLVSSYKITGIKISSGDKYYTECVSTDFACKFILNNPVIYKMQTSFCSVFGDIESLKINTLKSIEIERLDLLREDVDFFSKFIKLESLSIVKCDFLNYGDFLRKLALMFPKLKILRIVGSFLRSGFLNNLFFTYIEILDLSCCKSIGKISNFPNMQMKALKSLRIDYSSLNYKVIRVMIPSHSLKILSMRGTKCRIFHIFEHYRNLKKSFYYLDFSRIRFNKKLVSFFSVNIEAEILFLENLEHLGDLIRVLRLESLYSSTRTISLSNNSSFNDIFLLSKNFKKLECLKLSGTKIMRLHQFVFDFQFKSHLKDLDLSNNKFSKNYICCLNQFDFLERINLSNCNLESGLMEYLSVMHPAVSLRKINLARNILSKSDIFALEQFINLDHLTVCFQSEIFSYFLKEYGSLRLKNLETLILVASFFTSEIYHCIMRMSSLKNLELQGCHLEKNVFTNYRISYPSFLQKITLIDSKYYPEDIDTFNDLKFRGIEVLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI1</accession>
    <name>A0A4Q9LWI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0529p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000529">
        <property type="protein sequence ID" value="TBU13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0529p0030"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="735"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1034" mass="120410" checksum="2CCEAB1F6E35643F" modified="2019-07-31" version="1">MSNERKRLEALSEIYESEKLYINDLNVWCKDFKKYILSLKSLPPQRKYDLTEAVFSNLESILNLHCRLYEEMTKINIELTENNKFKDNGKYKIMDNNGIDGNNKNTINISVSLELKGIGKEDENVYSNLEYHSIYLENIDTFEIYKYYSGNLSLAEFEMDRELKNNRIFYREVTTFLKEKKISNLGIKHFLYRPSQKMARYDILWKAVLKNEKDEEYKNKISLLIDKFKSVNKIIDGVYGTTNEQFAVFKLSKQLQYKSYITSSAGFCLFQKNRRIIKEGDILVKTDFHDLRLLRVIILDNYILITDLITQPTGDMKYICEDPIPLVHYIASTTKIDEYEEKSPFIKDLFPLYLIDVNGKKIISFYFKETNIRDIYLKDISKAMNEIKSKFIEDISVSKIHEFKLHDIDCISCPDDKYGTKIIAENMNKQLKDTFNQNKIEMKRETSDTNENYSSIQNVESSSFKSETTIGADSNKNDLENKNDKKENLNPLCGDLEHKNDTMRSEDETKEKMMALSESSKHENETDLKNQNLINRINNLRIEEPQYHEVSSDWMISDAHYNSSSGLTLDETHSMYDLSNNNNRNSMIDPSINNVGDKARNEMVQLDEPDPQLFDSEEIKSNTEASSNLNFDTNTNAENKNDYPSNNTSLNPDSTSSLYTKNNEFEKVESEVSNTSKIDSDSNIRTPNRNSEEISQRNEASAENNDAATHHSNRNIINPRKIVGGFFTKKILRMESSLRASTRRSSHNLNEARRKEEGFLLISQKNGVYKKYNGEITKVYEKSVKKMIYDIRMDFLIYQQGDTLLVSILEPESTFLEETIVMDDTDTFFYGMTMEKNYIAIKKLSSDTTGSIYLFEVFQNDGYLKIKLYRRLYIGSHISRVEFLKAKLIIACKDFEIVDSDTLRTQELIDPSDPCTPYLFFLLENSYAKNIFKITNTTFLVCFDSIGFFIDSFGHTIQRNIIFSWHCIPTDFKMFENYLVCLSSDHLSIWDVTNANIVFVKYIRGLRFVEGTTKPLLHDKRSLYLLTLPSKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ2</accession>
    <name>A0A4Q9LWJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0524p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000524">
        <property type="protein sequence ID" value="TBU13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0524p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="631" mass="71378" checksum="402F4CE7E5054BE3" modified="2019-07-31" version="1">MNLEWKNVDIELVNKNKNVKGEYVRLINNSSGNVKAGSLCAIMGPSGSGKTTLLKALTGRIPSGSKTRGKILVDGKQRKYETWSKNIGYVDQDDCIFENLTVFETISYAAQFRLKDKNIDIKEKTENLLEELEISDISGSKMISVSGGERKRVMIAIELVTDPKILFLDEPTSGLDSSTSFNLLRLLKDLSKSHNTTIIFTIHQPSVEIFNTFNQLILLSDSHTVYSDEAQKAQEYFESYGLKKRELSTFPDFLSEILKVKKKYKELPENQAIIAKMVNDNQKNFSQTDAGSFSSSNTLAVEIRPSLGHIYILFKRRCKLYLTFKKIFITLVIFAALTFIYIYFSKLMIGEVPKLLDAIKFILSVAKKVDNMPILETSSRELLAKFDIIKDVLGCIICASFLSILFGYYMIPSTGAFGYEYNITKREIGVATYSIGSYYSSVFIFEFLIYLPLLICSSICAKIFISEAIKWETYFFILGALIGYLPTILFFGSCTTRTKTIYAVLSCLAFTWAVPGYFFAVLNFVAIKTENILARIILLLISIFPPVQYNCLLIGITYKIKSAACKGLQADSKLKNSFDFFAKMFYSLIFESLEVWQACLIFIFSTLVFISISILALGLRLKPEMRYKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK3</accession>
    <name>A0A4Q9LWK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsJ-like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0669p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000669">
        <property type="protein sequence ID" value="TBU12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0669p0030"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="269" mass="31022" checksum="91D3EDB406BC2C3A" modified="2019-07-31" version="1" fragment="single">LKSKEKRDYYYKLAKEQNYRARSAYKLLQIDQEINIIKKCKNILDLCAAPGSWSQVVLERRNNEETKVVAIDVLEMFPLDGAIMLKEDITSELCVQRIQNIMNGEKFDLVLCDGASDSTGFHFKDEFVQNELLLSSLRLSLRTGKVGSSFLGKCFRSENFCKIIKIFYEFYENVKLFKPISSRAASIECFIYGEGLKRVDNCSLSFNLFDFNLDFSEMQKYFLQIQACGTGPDPDISTNDNKAYKESKYKPIDPPYKPSIQIRRNNSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR5</accession>
    <name>A0A4Q9LWR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0819p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000819">
        <property type="protein sequence ID" value="TBU12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0819p0010"/>
    <dbReference type="OrthoDB" id="2191424at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20765" checksum="2B5911F71012CB12" modified="2019-07-31" version="1" fragment="single">PFFSSRNYVYLEKNNSFLKNYDKENWFKENNLNSFNHQYQSNEVNYFKNKDQNIEDSTKRILKFFDWNTPLRLAGLYIYSEILCVDKNFMLKFRFERINGSFDIKKNFVFYKLPSKKLVCRICERNLADIKVLDDPILPENQKIICKNCFEAIYVDNNGDLRYPDIIISKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX70</accession>
    <name>A0A4Q9LX70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0454p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000454">
        <property type="protein sequence ID" value="TBU13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0454p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="810" mass="97098" checksum="C5B534C813A6E565" modified="2019-07-31" version="1">MFNCKIYKERKKNIKLLKISLDMFIRSRNRTFKSLLNIISIGCMFLRLFLTLNSIFCLKVQFSAIIEAEEYISFVENDNYKNLDEKTYYVNENSILIPFNTPVISKYNDNLFSICYPNDISLSFGIFDQLALENEDQVTIYIENEDLYAVSYFFNLLTIDDNIFVTIKPQTFFKILKYLNIFKVMRNKKYKYCIKILVYYSLIHNLDFKNQAFKPILNHLKFNNLHVRDVIECFLKLYMMKKAFIYELFLEYNQPKSISSIFHSKKHKKNDDFLFMKFHTRYLYKYLLKPNFRDNWTSIMHIFWVQKLYLNLCAYGNNFDMKIICSSLPKNFEKIIFVIVEELLPIFDYLLNNEYFTSKDNVKFIIYDNPEYFIDKIFYFKSIKKLTLEINQVYIEHIIKVENLTIYDKIESLKLILYSFSSLILQNSAFSLSGRNKKFFIDLENTVYISDLENQLEFFQTYNFQNYLTKVNLCLFRETYDTTYFAKIFNFNLIKFLKIDLENVQNNFLVSYKFLESFEALRGLSFENIKLTNKLFEVILCSRKLTTVLFDNFMVFDENELINQNLFNNSILFLGFYNLNMSLNSLFFLYLSKFAGLKRIILNLHHNQSLDTNEYCFNDEVRYLNIPKPKNHRYLPSLESLKYGNFFFAKNQTSSSILKILYNLFNLENLIELKYNTGCLYKEDIEIFSNLKSLKYLKLSIQNKSSDVEILRKILRLNISNKIFKLDIYAYKFEISEILSISNFKKLKILKLTFDSDEIIIRKNLGILYRMNFIKLDIYKFEINPLLDSYGYAKKIIFSSSLLNQSHIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH6</accession>
    <name>A0A4Q9LXH6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0766p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000766">
        <property type="protein sequence ID" value="TBU12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0766p0010"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="24543" checksum="466D51E76BE05C1B" modified="2019-07-31" version="1" fragment="single">MANLTQKEENSIPYWKLNANEKEFLYYYCLTKMEKINQQTRYKKIKCFLAKNLCCGKQQIKFPKSKRLEPIIFELIERIVNSEPTVAYLFFHREKLLDNDGIRLYIDTIKQYGVDIYQIKEIANLLISLIKVYDGLFHRELAYPLHKAMFMKPNGKNIEFFLYYMRFAFTEDERKLFTELRRMFIYLSNNNSSIYRSLLIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU2</accession>
    <name>A0A4Q9LXU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0520p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000520">
        <property type="protein sequence ID" value="TBU13137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0520p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="7797" checksum="F3A907F49E46A9D1" modified="2019-07-31" version="1">MDKKKLTIFIVIGVLVFVGIGITIWAIVENKNSLSFGGGSAADAGKEAAEEKKEEDQNNHSTRFLRVFIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW0</accession>
    <name>A0A4Q9LXW0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0712p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000712">
        <property type="protein sequence ID" value="TBU12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0712p0040"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19864" checksum="FCCFC3489AE00167" modified="2019-07-31" version="1">MVKFKIFGSKLPTEEEKEPQIYVANIFAKNDVYARSRFFNLLNTKHKIKSTKACVLKVVPITEDISEMVVKNYGIKFYYRSKRCFHNMYKEFRAISRISAVEKLFSDMGGRHEVKNDMIFIVSVSEISDEEVKRPGVKEFCGDEVMFPLFEKNINKKSCTFVPKDSNIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY0</accession>
    <name>A0A4Q9LXY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative double-strand recombination repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0387p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000387">
        <property type="protein sequence ID" value="TBU13584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0387p0050"/>
    <dbReference type="OrthoDB" id="2195410at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031509">
        <property type="entry name" value="Mei5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17021">
        <property type="entry name" value="Mei5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="17004" checksum="A3341FBD2A078110" modified="2019-07-31" version="1">MVFITEIKEDEKENYEEIIVDTIKFYKRKEITEPSKRKKSITKPKRYSDQFKTPAFLNKDMHRKLCMIEKFRKNKNNLDFIIEKWRNCVEECLNVLITDYFVGAKDIFRSFKLENYGFKYEDYGDLSDYKSEEEQNEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY50</accession>
    <name>A0A4Q9LY50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0683p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000683">
        <property type="protein sequence ID" value="TBU12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0683p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="8251" checksum="60B54F13D4F239A0" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA8</accession>
    <name>A0A4Q9LYA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0662p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000662">
        <property type="protein sequence ID" value="TBU12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0662p0030"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="5">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="4">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="26814" checksum="511B6533A30D7122" modified="2019-07-31" version="1">MIGIIDTSSLIKRNIKIMNYTKFYTTNSVINEIKDNETLAFYNLNSYKIEIMNPSTIYIERIEKINIEKQFKLSNTDVEVVALTLQLYEDNMQGWISIENVNTLESVVCLTEDKSMISALCACGAISDGFNVQRNYKIRCFTCYKIYDNDIDFCKKCGYNTLSRISFTETNEGIKFHFKKNFNYCVKDIKDKYGKPIKSADQRNYEIYKREQRKKEKENKKILSAQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ7</accession>
    <name>A0A4Q9LYJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0038p0060</name>
        <name evidence="1" type="ORF">CWI38_0300p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000300">
        <property type="protein sequence ID" value="TBU15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000038">
        <property type="protein sequence ID" value="TBU20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0038p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0300p0020"/>
    <dbReference type="OrthoDB" id="2201200at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="445" mass="53646" checksum="937CE29DB0C30F4B" modified="2019-07-31" version="1">MSQFFKDFDDEEINEKSKKITKKAFFDEDSSEEKDKISKKEKKKNELQLLVISAEEDFSVKQAENIVKTFKKNSNIFKNDIPRFLKRFFLQIIEEKKSTASLKRQVNEILKKYEKEDTIKEDEVVKTEEKRTEVFENKLLVILEIENYKTKIETLFELSKSKNLQDSELAKIYMSLLGIFNNEIANTKSENTPKKKELLKEIFIVMNFLLEIFFKHDTLFYENIDLKKLFTENLNFYIVKIFDIIDESYFDACRDLLKKTESISLEISKSKSLEFSFFYDNKIIENEIFPFNILYLLRINEYEKSKSLYLESEYIKTPAYFKVISELGIMAFYKQDFIFSFKLLQECYFEANFHNLENYLLIMCVIHEEKVINEIFFNIFLEKIRLLENNKLILKAYDSKLEIFRAYLFLYNFDYKKSYEILKKIEPRLECYDVLKNRVLKELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL9</accession>
    <name>A0A4Q9LYL9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0248p0040</name>
        <name evidence="2" type="ORF">CWI38_0420p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000248">
        <property type="protein sequence ID" value="TBU03702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000420">
        <property type="protein sequence ID" value="TBU13476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0248p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0420p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18715" checksum="D4A4C4038D8AFAB0" modified="2019-07-31" version="1">MYLFFFVLYRAAIYNSKYFIITPAAHPFLHLTSRNTIVRLKNLDSAPNSVKDIDVFELIPSGQKFKITSHNGFDLCRTPELKGRIKGCKNGDENARWSPTITPDGILFRVGKLCLTATKMDTNPSNKGIILEARRCDSRKEQYFDLIPLKDFLPNFNNIFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM2</accession>
    <name>A0A4Q9LYM2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0293p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000293">
        <property type="protein sequence ID" value="TBU16709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0293p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21862" checksum="778BC66F7407C4D5" modified="2019-07-31" version="1">MYVYFIRSFLVLESLILKSKVLSKIRYDFSEFVSDDLKYMEIHNLTFNEKDRFIFTRFVKMWYLKISNCSFKGINFNEMFSPYKEYKFTCIALTGIDILIEDVIFLKNLSHLTELNFNNCHFIERSYLSLTKKNFSGLKLLVCNIFFEDSRAFVDYSKDLTMFLSTEFSGDVLHVQNVFNHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM3</accession>
    <name>A0A4Q9LYM3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0554p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000554">
        <property type="protein sequence ID" value="TBU13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0554p0030"/>
    <dbReference type="OrthoDB" id="2190807at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="13048" checksum="E9356DED7AD14D59" modified="2019-07-31" version="1">MKIVLLLRKLKNQEVKIFTKENTIVEGQLKSIESNMNISLLGVTITKGKHVTKAGLYNLRGTNVRFIELPENFIDESFCDFNEKNKNAEKKSKKKNKNKIDVPSNIKRRKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR2</accession>
    <name>A0A4Q9LYR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0540p0020</name>
        <name evidence="1" type="ORF">CWI38_0660p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000660">
        <property type="protein sequence ID" value="TBU12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000540">
        <property type="protein sequence ID" value="TBU13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0540p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0660p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="41069" checksum="B2AB692CB73B91A0" modified="2019-07-31" version="1" fragment="single">MDKDDVMQTLTAETVDTIDNDDLKAIEIEKTEEYVSQGQNEMGNAYISLSKAHSEVEIALILEVILAHSLKESAAIEIYRRNKLRINYSKLIPRVIRECKNDQGIPQPSSYTPSTIINNTFIPPSEANTNTKAERQEFIRCVFFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAKPLSLPDTARFISLREKYLNNIKKISEEEIGKVAVRTRKLPNELVDGTVLDLINRIVGEYADSHVAMTITDVAQIIQTAQVCYDDETRKERPRSAWKESIESKISVLKLSKDILEKARRREELSSSQTKSLKKIMREFNLDLNKTNDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS2</accession>
    <name>A0A4Q9LYS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0595p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000595">
        <property type="protein sequence ID" value="TBU12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0595p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17434" checksum="B37387E248D66719" modified="2019-07-31" version="1">MMKVKELIQLWENRIQVNKANDKTEYMFSEESSVFIAESNKRSDGLEIKTIDIVFEENHEKIDIDKSTTENLIENTPIQNTRQYSQQDVLDLINEMVIKIKNTRIELTIPEENYKKTKYKKIFKNRGYSGSHYTMIGINGQLYDIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH7</accession>
    <name>A0A4Q9LZH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0214p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12715" checksum="F707FCC6447CAA7C" modified="2019-07-31" version="1">MKLRLYYNLYFLIGILLYILAENIQNYRFTVNISANPIIYTDEYKVDLYNRVSEKLCTNKFCDILQELRNNTKTLEQCREEIGNWEDLLDDEREYIDMLFVCGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW6</accession>
    <name>A0A4Q9LZW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0181p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000181">
        <property type="protein sequence ID" value="TBU19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0181p0030"/>
    <dbReference type="OrthoDB" id="2196367at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="542" mass="64217" checksum="7AE5D7E574F40056" modified="2019-07-31" version="1">MTDDVSKELATVKRKKLKIIIKLKKKPMKSTNESGIIEVDYIKSLSSLNSFFFYYFPHLDPPQIFVTDYKNNKYIARMEMLDTSIEFSNKYNTFETAYNDICNYGLQFLKEFVLETSIPRTYEFKKPLSKIFGENQLNSNPFLGDKKEIKCIEIESIDSKSMNKNNFCSENSMKLVSKNEVVLKEEDKNFNKTDERNLKLNTLDNQKPKVNTGITDRVSEEKNRNKFHKENKEISSFDSTRTKSLEYSNLVKEICVSNRIQFPEYTIEKQNGVFICYASFFEREFISDYFFDKIQAKEDVNRLINEWIVSSKIISNEKNKNPDKKDRRENENKKIISNTNQTNTKKEIPYEYDIEMDLIKLINQTEESMNNKPRVELSTGVPYNIEHQQNHRNFSGKKYSCNQMKNQGSRRNRRRWFWMQRNGINGNIEMSNRNPGSTKLYKKSELSSFWTSDSVYMNSQNVDFSTENNSFENINTNNDLYFQRNTDFNFKNYKNSNGVKYFENTFLENPYLQDNSVNQNTKINNFFKKSSESNDDTNFQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX3</accession>
    <name>A0A4Q9LZX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0179p0010</name>
        <name evidence="1" type="ORF">CWI38_0306p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000306">
        <property type="protein sequence ID" value="TBU15839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000179">
        <property type="protein sequence ID" value="TBU19890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0179p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0306p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="19407" checksum="A31B10664F86941D" modified="2019-07-31" version="1" fragment="single">MQSLRKKYDVFCIKIFTEVQPIDEHIDEFKMIEIFSNVFAGDINCLYGNYSLYSIDKTRSEIYDAEDSCILKISMKTIINQYILGFRYGYQGNTDRNGILTRSRINFEFKSNNHKTEFHYFYSLKNMKDNDYKFKIFYKHSFVMFEFNFNWYTTQQNVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J3</accession>
    <name>A0A4Q9M0J3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0352p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000352">
        <property type="protein sequence ID" value="TBU13721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0352p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14812" checksum="4E1D36904C599BCC" modified="2019-07-31" version="1">MLYYMLLVSIKSTETGPQRDMNCMRNNISTEEMLESQSIQQIDDEKIFFYCSMEELTAFDAKSNSNSSGIDKEVIENMNPSEIKRSCLFISSLDSIKRNSALNPEIPLINIISLIEKKRDTDKSNQNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q0</accession>
    <name>A0A4Q9M0Q0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0237p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000237">
        <property type="protein sequence ID" value="TBU18517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0237p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="18779" checksum="C275988D30838062" modified="2019-07-31" version="1">MTPSTYKDYVIYALENPHIVHLIIIVFSLVLASIILAVFRGIFALLYGILLIFIYKEGFHITAFAELGIQNEVLRGIIFVAIAVFGFFIIAVKLNEVLFALIFSFMGSVLLLITLEAFLKQKWGYESAFRDLKKKVLPEIRSDSLLILSIIIAVSFGIQLSSIIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q2</accession>
    <name>A0A4Q9M0Q2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol hexakisphosphate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0109p0010</name>
        <name evidence="1" type="ORF">CWI38_0514p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000514">
        <property type="protein sequence ID" value="TBU13156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000109">
        <property type="protein sequence ID" value="TBU20224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0109p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0514p0010"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1088" mass="130367" checksum="E6AEEDA4BDF56595" modified="2019-07-31" version="1">MEINKYSRFGFILTSSSILKCELNFSKHTNKSKELENNINTHSTYKNIHGIGQLTISELEIFFEKFSCEEEIFWFNLREEPMIFINSCSFVLKDKNNPFEDIKFMKGVSCENLEIFEERLKREIIYEAEINGGFLQVNSENKKNETTTFFIIPYEILTVKEVFQNFKKKYKNLKYFRIPISSHSYISDTNSLNFLHKILYQSYSNTRIFIFNSKRGYTRVKFAITFCYLTVGVINSNNFLFSIQNTLKMFFEKLKRIIETKNKEKINDFDLKKNEIQIILKIACQGKYRVVENLLSILKNKKAKLNVDIALYNIYGEEDFKKDIIHKYFKYLLYKDTKYLNEAILRLEKYITLILYEEYLFTMKPVFYNIGFQAWLRSNISYVNLFKYISRKKDKSFIFSPLNLLPNINIEFNFLNILKKNKYYILKEHVPFCCRTTADKINFVPNLSEKYILADKKSVWFNLLEEPCIYIKNKFFIYRDYQKFYKNPTFFRGIDCQEIEKTEFEIKNQLLNELKRESKLIVYKEKTDVIKPYEILDIKYEDILTSIEYISKYKKTENFIYLRFPITSSLPLRFETFDKLFEHVSRFEKDSYFYVQSNGRKGRCVYISLLINLIYNWKYNINIETEDSKFHFKIIQRLVSVLENGIEAKNRIDHYFQIYFQESFIQFFLSIDIEKYKIRAIKRYFVLICFSSYLYNQSCKSFEEFMMNRLEILNMYNELNEITENNFFYDLSGFKDESICHVKKRNAHILGSMMILKYDYFIGSNIFSLPNAIKETQNFRYVVTGDNIICGIAMPTRKAIENVLKKMRSLSKNFENNIYWFCLREEPVIYINDHPYVLRNVEKLSENIETRGISVEIVENIENKLKNEILDELNEGMLLVHKEIIKNGEYITKGVWVKVNSVETTKEIFLKNSCIFKRYPITDERIPIPSIIDNIYKFIREIKESKLLIFNCQMGRGRTTTGMVIAKLVCDKDKIPSEKSRFYPPKYKIIELLLKILPAAQLSKQKLDEVIDFFDHLENLRNVIDDYNNGSNERISKGKRYLSRYFYLICFCNFYYQTDEESFVSYLEKRHEISNLEMEIENIGLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T3</accession>
    <name>A0A4Q9M0T3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0115p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000115">
        <property type="protein sequence ID" value="TBU20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0T3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0115p0040"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="605" mass="70150" checksum="11EF8CD729401897" modified="2019-07-31" version="1">MVVKRKIEETSEPLKDTCFVFTGEMEMPREVAQQKVVMLGGRYTSLPSRRTTYLVAGNEPGPSKMAKAKELGILVLTEKQFLDFIESKSKNFEDREVVDLEYKNDDKEPIRVDSKDEDKHDKEYKDIHDKEFKDIHYREFKDLDDIRISSEEPWSEKYRPKSKEELIGNQNIFSQLVNFLKGKTDYKSVLLSGSPGVGKTTAAYLAAKECNLTCIEFNASDVRNKGELNKKIKNNLNNFNLGSNNGLERKVLIMDEIDGMTSDRGGLAELGVIIKKSRIPIICICNDRSNMKIRGVANYSLDLRFRKLDFRQVLGRVREILKRENKNVRDSVIQEVFMQGKGDMRYILNILQVLCLRHVISSEEINLVCKKTFMRNIFDLCADIFMKKKIWEKIDVYFEDYSFVPLMVHENYLKSNLHISEVVISSDSISYGDVVDRIIHGPNQEWGLSGVHAFFSSVLPSNKPLNKKIDFSNYLGQNSKKMKNERNLLTCFLHGYKSYSPTKVSYRMYDSMVFCKKYLRNIYLEKYEDCVKIIEEMGILKEDIENIIEICYLGGLKDVPAKGKSTVTRLYKKLKRVLPYFVEDTKKVKGEIDSNEEEEKVIYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M120</accession>
    <name>A0A4Q9M120_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Co/Zn/Cd transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0087p0060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M120"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0060"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="227"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38206" checksum="031443ED66145842" modified="2019-07-31" version="1">MFCKNICTPTTDKTACRTNSDIKKLIKVLTVVLLFMSLEIWGHWYTNSLSLLADSMHLFVDILGFLVSLMALKWTKKTPNSTFSFGYYRMEILGALFSILFIWGTTGYLIIESYNRYVNPPKINGKIFFFISVIGFFVNIFCVYFLHEKNTAENSYHRNLNIRAAYVHVIGDMIQSIGVILASIITVLYPNFHIVDVFCTMIFSILVLSTTGLIIKDALLILLETTPKDVKIEDLKRDILSLENVHEIIDLHCWSISTNIKSITCHIFVSEILPWQYDSLLKKIKSLLKDVYGFDFSTVQFETQNTRINPTVFSIGGTTIFSPQNLKFYESQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M123</accession>
    <name>A0A4Q9M123_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0090p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000090">
        <property type="protein sequence ID" value="TBU20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M123"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0090p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="48430" checksum="9019713B569DCD44" modified="2019-07-31" version="1">MFLLNGISYTVNDLNEKLMQMTEKIYRCKEKTLRSFSDSDFYDIELETPTLSSEMNQLICDYITSSVTKKFNIFLEYVCNKYRATYVPNNTYFFTLSKLKSNSFLFGIKYKNNEDVSLPGKKIPKVWGKKSLKYLLNCLFSVSLIFRKLYPDLIGSTGLSYKYSFDSYRFMIFDSEFCFENIIALPNKRLISPAYFIRHEKNVFSTKLKVSGKLPVSHPMNDVDLIFKKSFNMFSTLKGKYRIKAAWRFANNSLESEHEKKFNLTTFYTRKIQLLFNNYNILNSEFLSIKEYISSFKFTSSDSSDSSALPVFEREFQVHFNWQKFSYSVQFVLNECDEFTRKYTLVFNIFENYELECEVVSDNKLNIIDIVKNFKTRSSRQNYYEPTDHDIIIMRIFEELICGENNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A4</accession>
    <name>A0A4Q9M1A4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0209p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000209">
        <property type="protein sequence ID" value="TBU19501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0209p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11215" checksum="87B9E1162C57530E" modified="2019-07-31" version="1">MKYKENDLYDLVANELGFIYKCSFEIISYSIVLNKTVETISFDRRRGLEASMCVVMRAEMHEKPTSLLKQASREENDKESELEEETTLVKRVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X4</accession>
    <name>A0A4Q9M1X4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0125p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000125">
        <property type="protein sequence ID" value="TBU20147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0125p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="22615" checksum="1286AED6BB8388CA" modified="2019-07-31" version="1">MILNCLHLHILNRYKFKSSKRIRSHSSGFQDKNRVGISLKDSFQIPETEKLRKYDLLVNDVKIISYVMTRNGIMTKYHKSHLKRHQTLHNVETYIQSIVHKKTVEIISFDRRRGLELEPNAKRAVKVRQWVSQHFTLKEANNKKDSVLQLTSNNITPFISEGEATFEVPTINISEESDFKEEPVVLKKVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M239</accession>
    <name>A0A4Q9M239_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0026p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M239"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="49909" checksum="B37FFEDE12587705" modified="2019-07-31" version="1">MTIEKFYTVLYFLEYFRVKYDNKLRNAIKIIWFSLVKSNEMINFNIEKVSLHFSKQDYFSYDLFKKNSQGYFELVNYKLDESELFFKKKMNIVFLMNLESFCFILKNIKKKIDEIVFKKCYISEEVICSLNANINLENLEKIVFLKSKIDTSLIFSDFLIKINEFLFYEYSHSESLYKVSEIKEGNFNMVENLIKNEKHPYQKSNLQESIRENNKMSRTNKKFYFKLFSKDKFMNKVKICESLCAASYNLKFKCFYEYNGCLINVSIDLESLHLKQFTIRDTIIENNIKKIVISISKMTSGFLKDLLNINGLESLELYNADILEINETYINDSIKYFSFQLKPGNNLKIFFKLIDMMIGLQEISFISFNNLTLNHMLNSEDSSYSLKFLLKNSDLSSIENLSLNEFSVDESYSEVLSNFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M280</accession>
    <name>A0A4Q9M280_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0224p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="38682" checksum="3CA862A6DF2C023B" modified="2019-07-31" version="1" fragment="single">FILQNINHLKEKINEKFFIKNIHLFPKLLEIRTYIDFLKIVFFSEYFRKPHVFLYFGIKKIYFFSIKSYKRFQILNNKYEEIENNTEKVFFGIFLDLIEIFYKLIDPNTKLNTSEKIQIRLERMKYHIRIKLATFLYKSYILVSNKTLRIFKQQISPKIFNFKYFLKTLNYRISQKIDINRIYYEDLVFKTLITIKNIISQQIATKRIFLENLYKEIQKLIFYEIPETTKKFFFYLKNILKNLHQTYKELKNISLKLKLKIKNSEYKIEINPLNTHFLNQIKNKILKIFQKINIFSIEFSYEKENIEENEIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I9</accession>
    <name>A0A4Q9M2I9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CWI37_1079p0010</name>
        <name evidence="22" type="ORF">CWI38_0077p0070</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23 24" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FI-OER-3-3</strain>
            <strain evidence="22">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01001079">
        <property type="protein sequence ID" value="TBU00208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2I9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1079p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0070"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="52"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="19">
        <location>
            <begin position="762"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="547"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="684"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU00208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU20397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="844" mass="98347" checksum="8728D131F2CB9381" modified="2019-07-31" version="1">MSKQKININALIDCAEVVKSQIKNKKTPYTDSQVETLKIYTDELTRTRISDFEIIRSLAKGGYGAVYIVKNKTDGKVYAMKRICKSEVIKQPHTALFMSEKDAMLDAINSEWLVYLYSAFQDKSYLYFVMDFVPGGDFMALLARKGVIPEEWIRFYAAEILLSLEELHLLGYLHRDIKPDNILITASGHIKLADFGSCAKKVDGKAHSSVTVGTPDYISPEVLNSMCEECQYGEEVDVWSFGVVLYEMIFGEPPFYSNSLQETYKRISNISFSLPSEISEDLKDLLKKTICHKDHRLSIQELKKHAFFKNLDLKNIKKMNPPFVPKILDETDISYFEDVWEDKDFNKNEKDEGFLNFVGFTYDLKIMDSFYDLIITNKTDIKDKIKYENFNFKEMHDTLNYTNSIAPGVNYTIKTDKILKDENSLNQTILKPNYSNEDHPPSPIYSEYIEKTFGPVIIEKTSKDSIVENSIYFRSKSVILENIEDIKNIVLKISEIEKDVDLLNQENKYLSSEIFLYRRRLDEMGNLTSMYEAEAKSLAVGVPDISVEEIKKQLRMKKTEIREYQQRLEEEIVQRQRLENELIKIKEEKEKIAKEKGNICTKGIFNVKILQINKDESYENSIIDIEDNKFSFQDKSSNINNVYLENLRNNELYHLTMKKRALIIKITFIKDVEKSISSMSRTSLKRVEQEIDRENQIKKGIEDMIKMLNGQVLENAIKQLEGSKKKIHQLQFELEKIKRCSLNEDSEEEEQPSNIKAYEFNNHRFIIKSFPPHTLCYHCNEVLYGLCDQGYECSECKMIVHKCCYVLTDVSCEVYKAMRKGVSYYVMLRNLEEKEKLFRIVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2R2</accession>
    <name>A0A4Q9M2R2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0003p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2R2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18357" checksum="911AB4E6A2DB0575" modified="2019-07-31" version="1">MFFIYICFFVQISKNTMVVDELEDMYENISDIDEDLISLPKSDFGSTLETISGVCVAVYQIDDNIYFRLKILDYKLKLASEKFRINSLRSDIINLWSAPTEIYKQFFLNKFYKKFLIIKKDLQEKKIDEKNIILYEALMNAIEGYLNVINDYSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2U9</accession>
    <name>A0A4Q9M2U9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0087p0050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2U9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2U9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0050"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="35151" checksum="02F8D5840AF7A924" modified="2019-07-31" version="1">MENYRFLEKIGRGTHGTVYLLESEGYKNKYVVCKSVGFKHKKYAIKEINILSKLSHKRIIKLLDAIIKEPYVFIILEYSNYGNLSTFIRFYKQSECNIPYDLIWSAFAQITDGLNFLHKNNIIHRDIKPSNILVNQNFLNNEEIIEFKICDFSLSTKLLTDEFFFDESLVGTPYYMAPEIIKRIKYNSSVDVWSLGVCMYEMICFKKPFLSNTRKELLELILDKPITFIPNCSDKKLQSLILECLQKNNRIKSYSLLSDEKIKYFLTLVDLKLKELKICSLEKKLKRWKKEGLEIHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Y8</accession>
    <name>A0A4Q9M2Y8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0051p0020</name>
        <name evidence="6" type="ORF">CWI38_0063p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000063">
        <property type="protein sequence ID" value="TBU20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Y8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2Y8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0063p0030"/>
    <dbReference type="OrthoDB" id="2188625at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="546" mass="62561" checksum="4E529808BF7FA4A6" modified="2019-07-31" version="1">MFELHNYQFKYFKKVYSHSGCINALSISQSGKYLASGSDDQKIVVHDLLDNVFCKEVCRLIGHRNNVFSLKFGMSDTEIFSCSLDGFAHVYDTVKCKIKYKTERSSHRCHKIDICSNSPNIFGVASTNGLFMYDKRVKKRIKMLATSQNLTSLSFNPFDSTLVISGNEGKLELFDRRNLSAPLLIYDTNIYKNRNHRLSISSCVFNQNGRYILVSPFYFLPLLYSKEHTSPTHIFYNENVKHVCTMKNYSFGGPSDSFILSGSDNKAVIYWKFPPDPENSFHDFFKEKHNIVKNESSNKNISFNGNINYIEKNSISDLKPYDSTKNINLKSPNLKNNSYTTNTKYRSYNLLDYTVNRNITSNINSFGYENIQYKEQPIFPKLKTYESTINYKDSIFSKYSFKNCNPAIFTDSNVLKGFRGNINTTIMHPLYPYIFCSGIENCFYVYSPFEFTNTNENEEDNENTIALFEMLNDREDVDLEEYSDRIGDMTRIMNMKILIIIIVLILVVLAIPAGIFGWKKIKKGGNSTGSDEESGGKSGGADGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3M1</accession>
    <name>A0A4Q9M3M1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sentrin/sumo-specific protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0045p0110</name>
        <name evidence="7" type="ORF">CWI38_0021p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3M1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3M1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0030"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="131"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="326" mass="39224" checksum="8AA202CBA063EBB4" modified="2019-07-31" version="1">MNDYDFKLSYEDVSESSCDNDFCIKENIKNINITIKEENIQHNIGNDDKIIIIKNEEKISKYFDILNEKYFIDDFIYKFLCLSYSNTKRLVEIYLKEKFKTGNSSFDSYYDLNILIKKMLKKDIFVKKYKMGIYFTDFCTLLPRNWLNDKIINFYFKIIEEYSMKTGKFIKVFSTYFYTTLCEKGIEWVRKWNLNQDISNYELILIPIHKNSHWTLVVVDLYSKSIEYYNSLGFFDIFVCKKIKEYFIATGLPNYNCFGIRNIKNIPKQYNSDDCGVFCCLYARYRIENKEINFVYKKMNSYRKILIHEILAGEILYQIGHKFNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Q9</accession>
    <name>A0A4Q9M3Q9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0353p0040</name>
        <name evidence="3" type="ORF">CWI38_0040p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000353">
        <property type="protein sequence ID" value="TBU03120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Q9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0353p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="112" mass="13653" checksum="674FA193AC357102" modified="2019-07-31" version="1">MSNLELLIDSWNIKISKHIEKMSEFENFKKNVFIKNNSFKQNRIIRYYDKKQNDNICDLDIKFFTFIFFILFIFLCIKIWKVYDALKEKATIFNETNLFSFGFLNQLLLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M628</accession>
    <name>A0A4Q9M628_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1022p0020</name>
        <name evidence="3" type="ORF">CWI38_0001p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001022">
        <property type="protein sequence ID" value="TBU00388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M628"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M628"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1022p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0070"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="393" mass="44407" checksum="AF3CB38D7F67E572" modified="2019-07-31" version="1">MNDDRAIKITKTLTLKYEKAFSSNSIVEKFRFIGDLLRSVEDSSQSMKNVFCMTNPLVDHKNTTKENAVSEIEKACIIFLKDMAKTGKQMLFKDSPCAEAQAYIGMVYELGVFGVKENHKKAYGYYTIAARQNNALGTFRLAQCFEKGIGKTKNNEKALTFYRCAAKLGLIEALHTFGSILIYGDLGCPRDPASGIFYLKLAANRSTSSYPYPYFDLARCFESDNAIKEIISDDRYAFNLYMKGARLGCYNCQYRVARCYEYGNLQNERDMEKAIYWYKKASQAGQIDAQLALSSLYFTGIDNVLEKDNSKAYIWALKAAVKGHTVAAFTVAEFVEAGIGVKKDKIHALWWYTIASVLGHASANSKIDELQRRVQQETKLGEGENFKSRCRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX77</accession>
    <name>A0A4V2JX77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cofilin/tropomyosin-type actin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0152p0010</name>
        <name evidence="3" type="ORF">CWI38_1575p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000152">
        <property type="protein sequence ID" value="TBU04319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001575">
        <property type="protein sequence ID" value="TBU10742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0152p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1575p0010"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="1">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="156" mass="18152" checksum="91732B98EA040338" modified="2019-07-31" version="1">MAHETVGLDEVKRESEKLKRRESIFVIFNIPSFKPVEFAILDTYERTNSSASGDAMDEKEMRKIFDICKSKIKKNSCCYVIYDFGFYRNDRAFRNMVCLITYIPDDHCSANDRVIYSNSGLLLTSSLSISKQMTFNSFEEFTFNNLVERCSSHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL8</accession>
    <name>A0A4V2JXL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0799p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000799">
        <property type="protein sequence ID" value="TBU12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0799p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="15907" checksum="AD725A479A84C6E4" modified="2019-07-31" version="1">MKLICIFREFRFKKRQIRHIENQEDFKRCDRRNILALIFQIKDANPYILDTKQWILIQLCLINIFKICNEKFNSTEEPRISANTENKDYYRCGHQLGCLSDKCKCFLKRDQNNFFDRRSVLELGPNVEIEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN6</accession>
    <name>A0A4V2JXN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0724p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000724">
        <property type="protein sequence ID" value="TBU12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0724p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="22417" checksum="B29C2F36301A51CD" modified="2019-07-31" version="1">MIFNQIRANIYFFILYILLQFLTIQTEIIVRFHLKNDSIKKVEESDRKFIEKKSFLNFCSKFLTVKKECVVKNVKIVKIPLSDLILLNCKEIEFHKKNDGSDIDIDLSKIYYSEFMAFHLYLKSCYFPNNLISFEKFVRFLVALDELKVNFDSGFIKLIDTILFNLYNLFESSKYYLKDSDITDSMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS1</accession>
    <name>A0A4V2JXS1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0590p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000590">
        <property type="protein sequence ID" value="TBU12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0590p0010"/>
    <dbReference type="OrthoDB" id="2186863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="28040" checksum="203DB825A8813172" modified="2019-07-31" version="1">MNDKKILNVLIYCNICYKSYDNSKEEDSNLFISDCMHIVCKDCIEDIDFCKVCGKNNDFKLINQDLKKILTKNPTEMFIKPVDISMFQLSSSLNLILHLKYELNTYKDLLKRAKNELIRFKDAARSKNSKPGFLNINSNQPIQKNRNHISETVNKIYKKNFTIENQNNKTIQRNSPAKESKNILVDLTNGSKIGKRKRTSGFNTVSDLNINEASFSSASTSRLTLSTRKSIFKTPFSRNNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC7</accession>
    <name>A0A4V2JYC7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0032p0070</name>
        <name evidence="1" type="ORF">CWI38_0048p0040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="53649" checksum="F466257FAE1D293E" modified="2019-07-31" version="1">MDPLSRKLNEKCTKVTIQADAESHATNHLLFIHDLKLLAEDWSTLEEMTKKVKNFMNNIGLEINKEKSTTNDPCCEDTATLLEGIDVYKYLGIIEDSRGIPTSKSFEEVQTKLIVRVERLCCTRLNSKNLFQAINQHAISLLNYLTGVLAPEPADFYKLDYAVRAVLVKNKIHLCPECKERLHSVEFKSEHMLLPLLDSAILKVVNNNKTHLSLIKNFLKIKYGLEKDLYNARKNEIVSVSDSLRWLKKENIRPRDEAVFAESKIEMYSAEQKTTRCDKMLGHDYTRRHNEVVRCIHLLLLNKYKSHSVQEIFDNEYAEIRVDTRLKTDTRYNYFRQETEWDNPHQIKTEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIRLQIPMNIEAYIQSIVLKKTVETISFDRRRLFIDEEDLMSLGAEIHKQPISHLKLVDNEEDDLEDEIEVVETVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG5</accession>
    <name>A0A4V2JYG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0006p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21970" checksum="062A839A9C744528" modified="2019-07-31" version="1">MFYLDRSFSSLEKFENGALPPIFIHSMNHTLKIYDRNIVSLNILTRLNLFEINVSQFNSKAEKESKTKNTKYFCTYKFLNLDISIYLIKPKIRKNKNKDTKSDKNILKIAVKSLFEPSSLEFNFYYNEKNSSITEIICIGTCENFQSNYSIKEKLNFILRYLNSMQTLYPENYIFSPIEKRTHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KT93</accession>
    <name>A0A4Q9KT93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2446p0010</name>
        <name evidence="3" type="ORF">CWI38_1197p0010</name>
        <name evidence="2" type="ORF">CWI38_1731p0020</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002446">
        <property type="protein sequence ID" value="TBT97179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001731">
        <property type="protein sequence ID" value="TBU10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001197">
        <property type="protein sequence ID" value="TBU11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KT93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2446p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1197p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1731p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="88" mass="10122" checksum="EF9A14D7A24DBC4A" modified="2019-07-31" version="1">MKLSKLNLFIICRNSTLSDDCLSETIIKVPEIKTNSNIRFGRSIPESNVDYEEEKSLNNDINHFLNGLYSTRNVFLENEVIKAINKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KX02</accession>
    <name>A0A4Q9KX02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1335p0020</name>
        <name evidence="4" type="ORF">CWI38_0918p0040</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001335">
        <property type="protein sequence ID" value="TBT99462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000918">
        <property type="protein sequence ID" value="TBU12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KX02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1335p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0918p0040"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT99462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="111" mass="13076" checksum="0C5E83A7B6CB5763" modified="2019-07-31" version="1">MKIQNKMENREVEIQENEKLEKELEEKLQENENIMLGKEICPFTTAAQDLLKQREISYKYYPKESNPLLTQAISSLHGGKTFPQVFLKKKYIGGLNEMQIYFNADCNNREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4M8</accession>
    <name>A0A4Q9L4M8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0472p0020</name>
        <name evidence="2" type="ORF">CWI38_0668p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000472">
        <property type="protein sequence ID" value="TBU02478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000668">
        <property type="protein sequence ID" value="TBU12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4M8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0472p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0668p0020"/>
    <dbReference type="OrthoDB" id="2196297at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="329" mass="39344" checksum="B47CE7B82C293F01" modified="2019-07-31" version="1">MNFPLDIKIDVFKSIEVDLEPQLETKKPKRRPNDDYDYEDPFIEQLENEYEAVELECNLSSFFIYSGKMPFDRQKVIKKYENEVKKAGTKDRKKRKDIIKEECTVKRCKIMEEIKEGTTELENKFLEIFLLQLIIENVDVNTFLQEMKELNKDINEKWIDKEYLKLKSKEIQCEFERYKNEITSLIGLKCHKHTDDLPVCKKDLFNSVFYDMVVIFIDLSFKLLYLESYLNETKRITEDVAKKRIYNDLYKIFPEGCDCYKSLGYNIFRYKQRKKSDKTTDTDTEMMTSIIGSLDKDSLTKDSEFFDTQIIENKNTEETFETQDDEKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7J7</accession>
    <name>A0A4Q9L7J7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0281p0010</name>
        <name evidence="2" type="ORF">CWI38_0202p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000281">
        <property type="protein sequence ID" value="TBU03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000202">
        <property type="protein sequence ID" value="TBU19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7J7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0281p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0202p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="154" mass="18688" checksum="135FAF57B89BE461" modified="2019-07-31" version="1">MEKEIEMEMNLRANYNKYLREILIGLDETSEVTFFVEMFVKIIQRYRIPMYSTKLVIQKIKNILLSNFIDSLVELWSQIVIIYEDFILLDDFIDMYSMMSEKSIFICKIKEMKNTFGFYYIKFIKDFKKNREFDEMVGELENECNNFVSKSIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9Q0</accession>
    <name>A0A4Q9L9Q0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0196p0050</name>
        <name evidence="7" type="ORF">CWI37_0382p0010</name>
        <name evidence="9" type="ORF">CWI38_0666p0040</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000382">
        <property type="protein sequence ID" value="TBU02966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000196">
        <property type="protein sequence ID" value="TBU04015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000666">
        <property type="protein sequence ID" value="TBU12697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9Q0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9Q0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0196p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0382p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0666p0040"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="6">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU04015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="219" mass="24444" checksum="7EF8D8513A496027" modified="2019-07-31" version="1">MENQSTIARFIQSGIKYAEINEFLSKELREEGFSSMSMNSYNLPIQITIRALKTHEIAGDKKTRIKALQSVIAQRLNVQETDVVIALESVQNKGLCPFIQADSIRQKIQANIPFKRAVNGAIRTIKEAGAQGVMVVVSGKLKGQRAKSVKFSDGVLLHSGQPCEDYVRKGFTSILLKTGVIGIKVYIMLPYDKDNINGPNKEMVDKIRVFDNKDEMIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAR7</accession>
    <name>A0A4Q9LAR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0118p0040</name>
        <name evidence="4" type="ORF">CWI38_0326p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000118">
        <property type="protein sequence ID" value="TBU04566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000326">
        <property type="protein sequence ID" value="TBU14424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAR7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LAR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0118p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0326p0010"/>
    <dbReference type="OrthoDB" id="2191718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU14424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="190" mass="21945" checksum="2229CE7402F961E3" modified="2019-07-31" version="1">MEDIKCNVGVLKDVLGSSMFSFKGTVVYCAVLHMSEPPLRHEDDEKAYVEVKCKTSSHFHSKELERYISNYINKIIHKFCILEADKFKMMQINIFISEKYSNILCCAINSCLLALLDAGIPLRKMFYAVSTCQYEEEAIVFEKEKESFIHIFSHAFGKISADAIQKAKKDLEILEEYILFSLRDKFILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC14</accession>
    <name>A0A4Q9LC14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0048p0010</name>
        <name evidence="5" type="ORF">CWI38_0205p0050</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000048">
        <property type="protein sequence ID" value="TBU05106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000205">
        <property type="protein sequence ID" value="TBU19523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC14"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LC14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0048p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0205p0050"/>
    <dbReference type="OrthoDB" id="2190402at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="273" mass="31664" checksum="6E4961B31392FEC9" modified="2019-07-31" version="1">MSKIFETRYEPDCVLFLNEEVIYVGCYSHLDGKRNGEIISYPEKLFVDTTGTLDLKLSDNKLFAANVSDISIYNADLSLHHSIETTSLNTYIEPYNNLIVSCDINGSLNIYDLSHGNKQSYNLSDNILWVCRKNDNYIYCGGESGTLFIKDIRTSENRNINIENNITFVDIIGNQIYVCSYGNTLKIYDQRNYKLIKNIELDSGIWRIKRTDNHFFVSSMYDGFKIFDTKWNLLNSFKTDSICYGIEVYDKKVAFTSFYDKKVFVLNFNELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEZ1</accession>
    <name>A0A4Q9LEZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2547p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002547">
        <property type="protein sequence ID" value="TBU06573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEZ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2547p0010"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="542" mass="60158" checksum="B6DEE45380AC8F58" modified="2019-07-31" version="1" fragment="single">MDSSTFKDIDITTYINTQIQHPTLYIIKTQQHTHNEILKSLNNTLYTTFITNTSNLIQILSKYGNILIFFYSLKKKTVKYFSKYTLLCNEDFCIEKQLLKISKKQKNIFLQHLSLFIDDMSVFITDYRYFIEEYKVEIVEEGSSIIDKGNSIIEEGNSIIEEGNSIIEEGEESNSIIDKGNSIIEEGGESNSIIDNKESNKSNNNKYNNKDNNNNNKDNNNNKDNNNNNNKDNNNTTHAILIFTNDILIIGTSTSNNKYYLYNAFNYNLLSLSYTSKYITLSIPTKKIIFKSLNSNMIYNTYKSIITLPEYVKVKYLNKLYAYFLYNTVNYKELYNYVNNGYLLDIDLKLEKLTSVDEVITLLKVNKEIHKKIKGYVIEHSSYNIKGSDYKGDSNSGVGLEGVSNSGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGLEGVSNRGVGVEGVSNKDGSREGVSNKDGSREGVSNSVDDYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGS1</accession>
    <name>A0A4Q9LGS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrP8 U5-snRNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2633p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002633">
        <property type="protein sequence ID" value="TBU06150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2633p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="2">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="569" mass="63337" checksum="21E86B69A5BA0D91" modified="2019-07-31" version="1" fragment="single">DKCINNLSRDRCINSECINTNDNTNNNTTNTNNTNNNNNTTNNYILVTSTVSNLYKNIDLTLLYKLLLLIIDETLCDYIISRLRCTLIYKDIKVGVNYGVIKGIPFSCYICCYYSVIVDIMLIGIEGVNSMCNDRGISNRGSVVGGVSNRECMLEGVSNTSGLEGVSNTSGLEGVNNRECMLEGVNSMCKDRGVSNTSGVEGVGKRDSKLEGVSNTSGLEGVSNRDINEGVSNTLDKQQGVSNTLDKQGGVNNNTNSYHPLNNNTNSYHPLNNSTTYHPLNNSTTYDPLNNYTNSYHPLNNSTTYDPFNNYTNSYHPLSTTNNNTNNNTLAHYLRYLDTSYILLRLSDNNIIDLLSNLKIRRRIFKNKYNKEYIIKDKILTALYMEYSSRVLSSVCSIKSKDFSVSKGESLYFSMGGFNCKIVRGVSNKDMLKGVNASRYILEGVNDTSRGLEGVSNMSSRLGDIKGVNDKGRGLEGVSNKDMLEGVSNTTTDQHPYSTSTYNPLNTNTYNQHPLNPNNINTYNQHPLNPNPLNPNNQHPLNPNNINTYNQHPLNPNNINTYNQHPLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHD8</accession>
    <name>A0A4Q9LHD8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_2386p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="PITK01002386">
        <property type="protein sequence ID" value="TBU07538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHD8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2386p0020"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="10">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU07538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="453" mass="50487" checksum="62361033D6D25FB8" modified="2019-07-31" version="1" fragment="single">MMLALQDILMRYYRMNKIPTLYLPGTDHAGIATQTVIEKNLLSQNIHLNLLSKKEKLNLLYQHTSLYQTRIYSQIKRIGASLDFSRQKFTMDSSINKAVIHSFIILYNKNLIYRDNRLVNWCGALHTSISDLEVDNREVTPNTVIKVDKGEYLFGIMYYIDYPITECSVIGSEEGSGVIDISKGNDVIDISKDIVSDKDSYKSYKDSYKSNKDINKSNIDISKDNYKTVSNSTDIQHPFSNLSINTPSNPSNNNTNTNKNTNTNNNTTYITIATTRPETILGDTALCANPSLTHLKGKKAINPLTGKIIPIIFDEQATLDIGTGVLKITPAHDFNDFELSRKYNLDIIRVLNEDNNIEITDIIKEIESSNDRVDRGVGKMGGDSSESNIIEGVNTSTNIQQGVNTSTNKQQGVNASTNIQQGDNTSTNVQQGVNTSTNKQQGDNTTTNKQQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIC2</accession>
    <name>A0A4Q9LIC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2360p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002360">
        <property type="protein sequence ID" value="TBU07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2360p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12524" checksum="3F3C8A543D309FAE" modified="2019-07-31" version="1" fragment="single">YVKRLEIPMNVEAYIQSIVLKKTVETISFDRRRELEELGKTVNEFIERAYMHEEPTSQLTQASNREYGHPYSGRRNEIRKLTININEESDFEEETMVIQEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJB3</accession>
    <name>A0A4Q9LJB3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2282p0010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PITK01002282">
        <property type="protein sequence ID" value="TBU08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJB3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2282p0010"/>
    <dbReference type="OrthoDB" id="2188690at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="651" mass="76141" checksum="7B2E215A2C47CE04" modified="2019-07-31" version="1" fragment="single">MHTPQTCKICFLPSMQNKPLFHPCKCSGTQKYVHESCLIQWFATKSQTPISCEICQYKYRYKASAQYFPSSIFRFLILSVFWIFNIFLSSFTIKEIFLSSYTHILTSESTFLYIFKQICSDKYKIDFKYLERNENTSEFVLNTLPGIFITVISYLLFLFYHRISKCYTKYVLDRLYPPVLNTEYAMKKIRILQENKQGSCLEGAVSLCSNDNSITDIFNDIAFNESLYSKDGDFSGLNKIGAEDSDKISGIFSETKNRNERDKIMVSRKEDEFKRNIFDSKILETDSKDISKHSCLENEVIQDDRIFETAYIHPSPLKNENEFKPQISNHEEIVFENNEEIESNTSEVSTNTRVNEKEFGFGVYPFISLIFNVSILLVFIFPILKINNILESFIRSISTRILLSIFISNSIIYFVLRFLYFKIFKEENSYKNILKISSLCVKVGIFYFLEKIFMPYVLFGVFGWFKNVGKKETFFVYNLVLGHFMASTTNRVLLICTNISESNFYGFLFKSLDDCVLTLSYVKGVGRILSFMFFNCILCGIFGFILRFYFVDDYLSLIGILILLRMKKKHFFYAVKYLYRFFVYAFGNKYNLKKKNGKFNLLFQISVAALCYLVCFSGFIFVGSKGGGIIFKKCEKITIFFEESFLKNKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJL7</accession>
    <name>A0A4Q9LJL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2424p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002424">
        <property type="protein sequence ID" value="TBU07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2424p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6218" checksum="EBF6BA44442D185D" modified="2019-07-31" version="1">MNFIIQRIVPLEMLIQMLDSRGPFEFYIIRCMPTGNIKEQVVLRYLSMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJN0</accession>
    <name>A0A4Q9LJN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2308p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002308">
        <property type="protein sequence ID" value="TBU08086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJN0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2308p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="995" mass="111494" checksum="A839C4917675632E" modified="2019-07-31" version="1" fragment="single">GNTPLGSSNNDYCGNTPLGSSNNDYCGNTPLSNILHILNTFLVTSMDNNNYLTVINTAMLHNIDIIITGCYYYCPYIYSLIKYQMTVKGFNVILIGKDKEGCYEGIYNIIYEEGVSDCIREVISEVYKGVDIIENMLEKGVRGSRDILEKGVSDKDMLENNVKGVRGIRNILEKGFSDKDMLEGNVKGVNDKDMLEKGVSNRSDKQQGLNDSPNTLHPVTNITNTYHPVNERTYKQQGLNNSISNMNTFNNLSNTNTFNNLSTINTFNTSESSLLSGVISLENNLLSLISNNNMEIKGVKSIIECKRVLDIKRKEFKELKDRNKEIRDIENNICYLYESIRKSYYSKYKVYLSNKVFKGVLRYIIKGVIKGFSERVLLEGVSERELLEGVNDRELLEGNFDRELSEGVSHRELLEGVNERELLEGVSDRELLVGVNERELLEGVNERELLEGVSDRELLEGVNERELLEGVSDRELLEGVNERELLEGVNERELLEGVSHRELLEGVNDKSSSREGVINSTDRLEGVSKSTDRLEGVSNSTNEQHPVSNNTTQHPVNNNTTQHPVNTNLNTTIANTLLSFYSYSYMPVDRQRVLNYKELRNEILNIELPFNYLLINLDVTLLKLKYVSVSCGSEENNKRVLDTINRESICIIKNVQFMPELKDMCSNYRGVNYSREVVGGGSREVVGGGSRDILEGVNDKSSKLEGVRGSRHIVEGVSDRDSMLEGVNNSREVVEGVGSCTSKQDPINSKTYKQYPFISSTYKQDPVNNTTNNYHPVNKSTKQHPFKRVIYCMEGNTQHSLMEDCRIIYGEQEYSYNNIYKTYRDIIREEGVSNRSKGLERGVSNRSKGLERGVSNRSKGLERGVSNRSKGLERGVSNRSKGLERGVSNRSKGLERGVSIVEGREGGVSNRSKGLERGVSIIEGRERGVSNRSKGLERGVSIIEGREGGVNIVEGREGGVNSKKKGVSNASIREGGVNIVEGKNRGVNSKKKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLB8</accession>
    <name>A0A4Q9LLB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subunit Snf22 of SWI/SNF chromatin-remodeling complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_2183p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002183">
        <property type="protein sequence ID" value="TBU09108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLB8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2183p0010"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="171"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="684"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="848"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="877"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU09108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125590" checksum="19BF935B50849D8D" modified="2019-07-31" version="1" fragment="single">GLEGVSNSRIGLEGVSNSRVELEGVNNLSNTQHPVNNLSNTQHPVNNLSNTQHPVNHLSNTQHPVNNLSNTQHPVNNLSNTQHPVNTNTNTQHPVNHLSNTQHPVNHLSNTNTPTNTPNTNNTPTNTNTYNTPTIDYFLTAHLISEPLLSQPSYLKGTLKNYQLKGIEWLLSLYNNNLNGILADEMGLGKTIQIIGFISYLTYNKNVKGSYIIICPLSVISNWKKEINKWCPTLSVIEYKGIPEVRKGIQRELRSMLGGGFGSMLGGSSGSMLGGSSGCSNSIYGSSNNNYTNSLYNNNTNNYTNNYTNNTTNTNTLPSNTNIILTTYEYVVKDKNFLSRIPWFYMIIDEGHRLKNKESKLCSVISNKYKSKYRLLITGTPLQNNLYELWGLLNFILPCIFNSNKSFEEWFNMGIGISRGECGSVGISRGECGSGSVGISGSNVSGSSVCGSTNNTGLLGLEEQMLLIQRLHKVLRPFLLRRLKRDVEVLPDKVERVIRVNMSGIQRYLYNRVISKGDNLLGSGNDVLSNSGSNSSNNPLGNSGSGNVLSNSSSNSSNNPLSNSSSNPLSNNNTNTPLSNNNTNTLSNTPLSNNSSSNPLSNNNTNTLSNTPLSNNNTNTLSNNCLVTLLSNITIKDLKGTNNTLMQLRKICNHPFCFEEVEGCINPSKSNNNLLYTICGKFNILNNILPKLKIKNNKILIFFQMTQVMTIMEDFLIMKKYKYLRLDGNIKVEERNILIEKFNNEDYFIFMLSTRAGGLGLNLQVADTVIIYDSDWNPFIDLQAQDRAHRIGQKKEVRIYRLVTSFSVEEVIYDRAYNKIRLDNKVIQAGMFDQRSTQEERDKVLSKEILGYRDREGGSDSRVGDSSKDGIRDSIRDNSSISKDSISKDNSSNISKDGISNTNNANTNTNTNTNTNTTLITTPITTPISNSINEMLARNEEELRLFEEMDKEYKEEGLVECECGKCNTSISYSNDYNRDTNRDNNNDYNRDNNDYSSTNNYNYNICNSSTNNQYTKNPNIHIHALLSDISGLEENGRRRIEIFMELPDKRLYPDYYIIINKPISYNCISKRIGKYRSMEELKEDFYLMFDNAMKYNIEGSVVYRDAYVLKEYVRGYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN09</accession>
    <name>A0A4Q9LN09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative non-ATPase regulatory subunit of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2115p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002115">
        <property type="protein sequence ID" value="TBU09793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN09"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2115p0010"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="203"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="49301" checksum="861392E87AE49D4E" modified="2019-07-31" version="1">MDELLNQEREARSQNDQERMIIVYKKIMENCKSDIERIQICKLLGKRKGLIKPAFKNLISYLIEIFTNQTSSKEILIDLLEKFLSEVINGKIFLEEERICVTNLLKKTYESKKAYLSALNSILIPIETFSTVQEKSIIEYQLEQLRLSNFVQDWIKGDIIIKKIRMRYFKETNDLEMERLFYQRANDFYIGQEKFLEVSEKFRLLKNFKNELGTVNFKINFDKENYENDESRKYKMENVILSSFFCIIALYENERENFYKRREILLKSNLEDDYNLIEIKEILKIFLSSDIITYENLKNIFKIFPFANIYNEKIINSINEHNFFVVQKYFKTISLNQLSSIINMSVEECVSKICFMVNNNLIDCKIDQRKEMVQFKIPKVEWKESVGCVLNRLVKANYLIHNEIIENEEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNZ3</accession>
    <name>A0A4Q9LNZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2008p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002008">
        <property type="protein sequence ID" value="TBU10119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2008p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="22399" checksum="E94175AE7DA3DAD2" modified="2019-07-31" version="1" fragment="single">MTGYIKNTGKNQVGSISNEGIDNNLAERQMRCQFEIEEEVAANSVKKNGLKLRECVETNKSSQKDDFFRNNEFKIMIGLHKNDSGLINKNLPVARFLIKKIMSNEVLEDKRISNIQNISTDTLNGEARDEKSVLSVSEITKKYICPKASVEKIKYFKDKEIEKIPGDSEYHMAAKTTNTFSIVPYKVNKVENQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPA0</accession>
    <name>A0A4Q9LPA0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI37_0451p0020</name>
        <name evidence="18" type="ORF">CWI38_1682p0020</name>
        <name evidence="17" type="ORF">CWI38_1872p0020</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FI-OER-3-3</strain>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000451">
        <property type="protein sequence ID" value="TBU02576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001872">
        <property type="protein sequence ID" value="TBU10293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001682">
        <property type="protein sequence ID" value="TBU10559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPA0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0451p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1682p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1872p0020"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000386">
        <property type="entry name" value="Fibrillarin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU02576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU10293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU10559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="274" mass="30764" checksum="4A5C94726D6A903D" modified="2019-07-31" version="1">MGTNFRQDQKRKGNFRKNDGRRPQSQGRRPSKPVAPKKVIIVPHERFPGVFVSKGKEDALVTRNMNVGFSVYNEKRISVTENDQKIEYRSWNPFRSKLAAGILSGLDNIYIQPGTKVLYLGAASGTSVSHVSDMIGPKGTVYAVEFSQRSGRDLINLAKKRTNIVPIIDDARHPYKYRMLVPMVDCIFSDVAQPDQARIVALNAQYYLKEDGGVVMSIKANCVDSTLPPETVFANEVDRLRKEGIKPKEQVTLEPFEKDHAIVVGVFRASKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPG8</accession>
    <name>A0A4Q9LPG8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brf1 TBP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1819p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001819">
        <property type="protein sequence ID" value="TBU10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1819p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brf1 TBP-binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24187" checksum="51638D472110DC65" modified="2019-07-31" version="1" fragment="single">KENINPNDNTVKNTEESLKSSKENINPNDNTVKNTEESLKSSKENINPNENTVKNTEESLKSSKENINPNDNTVKNTEESLKSSKENINSINKIEENTDENILIKGRDDLFKDNELHSLNCGKDTDSDINNFILSNEESKHREILWNEMYGEFMKQKAERPIIYRKKTYTKRNKNIQFETITDAVKSVVKEKKFSSKINYSVIERMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ0</accession>
    <name>A0A4Q9LPJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0738p0030</name>
        <name evidence="2" type="ORF">CWI38_1833p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001833">
        <property type="protein sequence ID" value="TBU10348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000738">
        <property type="protein sequence ID" value="TBU12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0738p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1833p0020"/>
    <dbReference type="OrthoDB" id="2189782at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="20165" checksum="B2DC9724DEA709CA" modified="2019-07-31" version="1">MNIKVKVYIYLLILILVTYYHFKENFNQEIEKEKIEMKKYFNEKVRKLNTNFVLENDNFKRIQVKIVKSYNRTNPELFIEYYNLIKIMINNLEYFNKKEIKKLLNGNFTEEKYFLAKKRIVYLKNNIDSFSKTIFLVYSWEYNLGIFLPVFLPILINVKRLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPV2</accession>
    <name>A0A4Q9LPV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2045p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002045">
        <property type="protein sequence ID" value="TBU10076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPV2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2045p0020"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="28945" checksum="AF09F443154D8105" modified="2019-07-31" version="1">MSLRNRYDNPIEAGITSHYSLQIVEIEELRNYGLLPNELGLIYKCSTEIIPYVMIWDGIVTKYHKSHLKRLKIRMNLEAYIQTIGLKTIVETIYFDRRRWAESKCTYDKGENGKGISKSTIPYNKIKPSWVTLSPEEIIQEILFLARKGNPPSKIGNILRDVHGIGQVSFITQTKILMLLRMHGLAPSIPEDLNSLLSKCYTMRSHLSNFKQDKSAKYRLILTESKLYRLARYYKRNMALPANWKPNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPY8</accession>
    <name>A0A4Q9LPY8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1724p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001724">
        <property type="protein sequence ID" value="TBU10488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPY8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1724p0010"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23357" checksum="FAFEDDA1340456F0" modified="2019-07-31" version="1">MHELIRNMNRRFVPKTGILEEKKADIFTDPKEIFDTWAKYFESLLNSMEEDKSDKEECYNNSAKGNIEAIEYPTLEETITVIMSWRNHKAPSEDKISAEKISDESNVRLLIPLHKQSAQMKCCNNRRNSPLNTGYKVLSKIVANRLEKCDEGIIGDYQCGSERRESYEYNIPTHQLFLDYKKAYDNVYRKYTFNFLGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ66</accession>
    <name>A0A4Q9LQ66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1719p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001719">
        <property type="protein sequence ID" value="TBU10494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ66"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1719p0020"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21568" checksum="2B9554CA44AB1A97" modified="2019-07-31" version="1">MYVVISGPSGSGKSSVIKLLMANNTNIKFSISYTTRQKRCEEKENIDYHFVSKETFLEMVKQKRFVEYTLYNDNYYGTPFCEEHENEIIIFDLDRNGVKSLMNSGVKCLFIYIHCDVENLKERLYKRLGNSISQENLNDIEKRISRIEKDLEVFRKEDYDLVVENSDLYQTYKTVEEFILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQY5</accession>
    <name>A0A4Q9LQY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1735p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001735">
        <property type="protein sequence ID" value="TBU10476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1735p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="612" mass="73922" checksum="E5AE37AFB87F6608" modified="2019-07-31" version="1" fragment="single">KNNNTFLKHLLVSSITNESFHSSDMFPKLPNSDYDRFQLNLEYLFSVFLKFVFIDKISNYTFLYFKNNSSSKDPLKNLSYRGYIRYKERLGNDNIIFLESHICSHLEKLLKYSWIKNSIICFIRHCNVDLYLIAMKMGKLKPMISNFIDLIKPDSLKKLIITDNVINKPTLKVLIHYGYFPITKFVKIICDLDIEEIHLILRHSQNIKRLIIESKEACYNIFFELKKHAIIHKNLNIKYKCNILIMQCRMNDIFQNLPENLSFYIRKFHISFTHCEFCMMKSLTFFRKVLIKYNTKKKLKKYKNQFYNCINTKEVYISTKQNKPEKIHRKIFKYIFRMEKLESILLENIIIPEILIWHILESKNLISIKLYNSCIPTHFSHDYNILNYILRSITIKESKYTLNDNFFKFLLLFRNLTFLKLYIKDIDSDFEMRNKHCTSRIINTPNENLIVKLEYLKVNIKEETIIDWSILFAFSNFFDISNLNILILPMHELNEKDAFIISNLRSLKEICLSIYRQKTEIMLKRLTKILENKFIKRIRLDICNLNNYMFEYIYKFKNFDMVFIHFQYFEAYDLNSLHRIRCNYPNSVIFLYEYNRLVSSEVKCFLKEHNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR90</accession>
    <name>A0A4Q9LR90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1390p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001390">
        <property type="protein sequence ID" value="TBU11093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR90"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1390p0020"/>
    <dbReference type="OrthoDB" id="2189586at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1035" mass="122191" checksum="3CADF25633A6F89C" modified="2019-07-31" version="1">MQLKVEYLKEIKNRIIGNKLEKIRLFEEGFITNNIEKYKNMKDLEIFSLYSEISSLLTTIKNDEINKTIKEFKIHEIIFEKIYFILKNFDTENKKYFLKLISAFRIIIGNLMPPVSFLMVKVLIIIIENKIEFDFESSYHKNELFRIFEIISENLSILGIFKSKKFIKIVNQSILDNSFNILYLLPFIERIIDKENILTIDMNNLVNRFYKSDIRVKLRIIECCIYWHLVYESIRIKEMMRNKSLIINEVDNLYDRIMNLKDEDLKGYIYFQNSVSDIEKIIESKNSNFCISINKPNINNSINSKNFFTEEFIEENDGSNFYEKIFFQDIDFSISKKFENQFFNVKNDDLTELTDNFDLLDFSDQIEMTESSVHPKDYKLDKPIIGRKGLEKYFKIQMKEKNTEKTKKKLEMLKKILNMLSSILFIERDKSLFLLSKLSQENENVQMICAILNFPDHLIDLFVDINRNNVSYVSVLYSMCAITSKWEENRKSICKSLVIPTIFAILKNKLSEKKFDETFLVIFCLLKSLTRSVTFLRTELPEYRIIEICLETLESIYLVDLNRKKNSSPRKMYEIIGHDSCLDGIKGRFLDSQEILSVSSTTISKKDNSTFFGNISNSNSSNLSFSSLNSESFENKLTINESSNSLNLQEKNHILEINTNFSENKNTLESQNGKSNKQFLDSNELISIESETISNEILSEKPLESDNLVENILVAIKKETFSILSNLLLEFGNYKNKFMDKNGLKIVVQKSENIEFNLFFLLKNFLYESNWDTKTYFIKNTEPDFFTKYIGEPTEDIYKKIISCFKNEIEFDKYYIKYRKLEDPDMISQTNNYLNDDISYIEITGRSNSSRNNVFENLNTSKEKPLNFQQNIPIQLSVPAMEQLMNVLRNLLCGTKEELKYIFRRFNSLLNSIFCYFKKLTSRVNRSNFPIITQIIYIFVNLSANNLKYKKMMLHDEIIDGIIELTKFKNKKLELSILWLIINLSWKEEEGVKNRIKILKMKGLFNWLKFLEYNDPVFTDKVQTALENLSFYESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR96</accession>
    <name>A0A4Q9LR96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1428p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001428">
        <property type="protein sequence ID" value="TBU11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1428p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020670725" evidence="1">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="441" mass="52972" checksum="E9BECFF1ED5F73D9" modified="2019-07-31" version="1">MLLKSFLILVLGYYNFTIQTTSDQEELLSNDEIDNDNFVSEEYLWNQLTDFSRNCLKNAIEKNNIKSKNFLLSMQTSFDKFNERKEPFKVLSNNQLCFVLFFKVNEDFDTNDFSGLIYEVINTSNRYIKDLLKKNPILAKYANSNQLKNSYELFIKEKRKNSKFYLCIGFKKAIKEIINIDRFNKVKKRFFWKKRNCDLEKSFFVVFSDYLNEYDQITLYKAVKRTSRNYDPKCLNLHIFLKKRKSIIDSLSLLFDKSSHLSYYTRFSVFYFGKMELRYHEHIETSLNKNHESICLLETNLLKNSSINSQKNIYKIFSFDVFDKKDFFDLIITNNLIFKSFFNLKFSIFIEKYKTNNRNKVHKEIIFYIVLGLNDIKKYKFTLKLNLDNEIMKFKVKRYLNGETKSNKIKIEQIAEMGLILKEIAYEYEIMPLNISFFQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB8</accession>
    <name>A0A4Q9LRB8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1641p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001641">
        <property type="protein sequence ID" value="TBU10626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1641p0020"/>
    <dbReference type="OrthoDB" id="2190819at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="6">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="535" mass="63040" checksum="4ECE59F73D70A11F" modified="2019-07-31" version="1">MSNFLRNPWIKNGFQFSLHYPARAQIIQILGNNENNTLKVLLSDSTNIVLAVLSKESLERFRETVATPYSEIKGCFITLEDYLYCYDSNTSQPYIFLKEFRYCGSESPIIGEPLDLIYDFDYKIAKEFKIFQPFSISDICIPKEEIKKQITPHNQQYLKEVFSEFYSDCNFLNENENIGCFSYNDGTEKEKNTNILTENISSRLNEIKEVNTSDSVHDSFSSSCPTDLILDSMQSENLFTENEQTNSWLLFHQNSYPLQTCIKHFNKSTDNIENYKSKYFNRICNIEDKKDTKNIPEFEEYLIKYEENLFENDIVDGLETTFIDEEDKNSNFYRFEEKNKTKSKNNKNNSVTIVNSQSSINTSSSEKYFIRQATEKNIFMSSMKRNENKFQIKLNTKNSIFKQKWSLKRNIKIKIKCSHFKNIERKVESFSEKIEESKNLGLENTVDVALDSNCRDFKRNSNKEINQRNLETKNLALDFNCRDYKRNSNKEINPRDLETKNLALDSYCRDFKRNSNKEINPRNLETEFGINENIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK5</accession>
    <name>A0A4Q9LRK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1411p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001411">
        <property type="protein sequence ID" value="TBU11054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1411p0020"/>
    <dbReference type="OrthoDB" id="2188018at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20268" checksum="9202DB2C26C74956" modified="2019-07-31" version="1" fragment="single">EGIKKEGLFRISGKYTYYKLMPGVLAAGKRYDYTELSVHDNASIFKAYIREIMNGIISVQVAERVMKIIKNQTDPSIIEYIVPLIIFSITNENRKMLIYLQKIFRKVNQYSKDNKMGSDNLYKIFTPTIFPNIECYDLQSINLQIEIVKRIFESNLIEIPCFLYEEGLSVAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV5</accession>
    <name>A0A4Q9LRV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1535p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001535">
        <property type="protein sequence ID" value="TBU10816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1535p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="93615" checksum="6B1B4C957ED4A16B" modified="2019-07-31" version="1">MNIRSISEFKLKYTYIYLLYFTIQIYTITACKYIYWFEENEDSEIILYSEIHENKLSGNDQEEKYYLKIIDDIDSTVMNRLNYAFTYDDENFVNFAVFNDFSKENKLKNRNAMIECNFELLYVLKITKNIFELPDTISFGQFKCLLFILRHLKAYENKNLFKLLQGIFSIIYCNKNDKKLINKESYFKEIFRFMFSSESTPNIKKSIIQAFLNILMIEHIFYENNLILTTKNENILETNLINENIPYRNLVINDFKAFCILENFFRNRDISNTFQILLNEINIKSLIINNYQGTEFLDVDFIFLKPLAHIFRSIIISNIFGSSENILNELYNAPNLKLEYFSLINLIVNCNCLTKFLSKHRLKGLVLNNVTMYNDINNFNSYMNSNKFLEYIEFKNIITNFSWLNRFTKASNIEKIVLVFESDVIEKDFIKECDLLIHSINILYLEIWFDRYIISKEIFNFLKCLKSLKTLKLYNYKPSSNIDCNICEVFEKMKALENLVFKNTYLSDKFYNLLFQKKELKFLDLISSLNPKSLLNLEPFNNYCSITHLILRSIKINRYGLLEISKLVNLKELSLKFCDVESVENTPPINFISRSINKLCLKSSNLYNSEFVGILSNLDELENLNLADFLLHSCCLSRLNIGCNTRLKALSYQRGSLCINDLNRLKKLKVLEKLKLYKCKFIYSSFSSLGEDCEFFNSLRHLSLWDIENNLITIQYLLNFKNLQDLELPFIPFNYSQLQISRVCLPKGLFLTEELYKIIKSKNFYNEIYSDNISKYFKEIGIEAVLKCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW1</accession>
    <name>A0A4Q9LRW1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1251p0020</name>
        <name evidence="2" type="ORF">CWI38_1445p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001251">
        <property type="protein sequence ID" value="TBT99689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001445">
        <property type="protein sequence ID" value="TBU10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1251p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1445p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="101" mass="11695" checksum="A6C6F27C0334A4F3" modified="2019-07-31" version="1">MSFGTLLITTNSEPIYVKNKDDINISLIIDFVDSMISVANQFYEDEFFYSEGACVISCFQCPGITKIIWVGSEKKDLKKIYERYRIAKIYNDLELLNDIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY0</accession>
    <name>A0A4Q9LRY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1517p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001517">
        <property type="protein sequence ID" value="TBU10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1517p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16463" checksum="07147CED5998379A" modified="2019-07-31" version="1" fragment="single">CSVEIIPYVMTWDGIETKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNSEESWERASMGVIMRAEMHEEPTPPLKEGKREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETAVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ3</accession>
    <name>A0A4Q9LRZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1267p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001267">
        <property type="protein sequence ID" value="TBU11323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1267p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="269" mass="27338" checksum="BE04EF8C5C95BB57" modified="2019-07-31" version="1" fragment="single">MINMSDILILIKMKPVSGRISTCFTKTGLNGQNKAIETMFAINKNINTENCKQNIMKFLWSAVGLLYLALLDANIIMNPENCKVTCSGQASTNDTSGGHGSSGSGSHQICNCYTPGTGGGGMGGGGGGGSGGGTGGGGGGISYRPLIYTPPSYPPPSYTPPPSYPPPSYPPPPPPPPPPPPPPPPPPPPPSYPPPSYPPPSYPPPPPPPPPPPPPPPPPPPPSTTCSITTIEECEEVPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS18</accession>
    <name>A0A4Q9LS18_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1255p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001255">
        <property type="protein sequence ID" value="TBU11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1255p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28483" checksum="C883EBA3A0B58C05" modified="2019-07-31" version="1">MTGRNQSNIIKPLKHIKNTCLLFVLALIQLISMYLIFMIPFITEILGFSAMAFTKHLTLLFIFLMIRYTYKENIPTIYNSYEIEFSFYFITFISFFIDEYFEKHPLNFEGKNIENFLVIYPIFLVTFHIKILLLLLNIGAMNNINIKHFINLVSSVSVISIAETVLKPIISNTKQLLMPRIFIYLSEFTLSSFILYRYISIFQATLFLIFYISLIFTLDSNLFNHVASNLSYLFDNNEYCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS39</accession>
    <name>A0A4Q9LS39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit p30 of RNase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0219p0060</name>
        <name evidence="4" type="ORF">CWI38_1259p0020</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001259">
        <property type="protein sequence ID" value="TBU11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS39"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1259p0020"/>
    <dbReference type="OrthoDB" id="2194280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="28009" checksum="1528145A39EE21F6" modified="2019-07-31" version="1">MYYDLNIQESFDTSDIQELNQTEYEGFCITRTCDSKTYANKDKIKKFKNLTKKIYSKVEIDIETEDYSTFLYTKIPCYDVISLKISNNTILKSAVKEWHPDIITFDFTNPDLKLHKGYIKEGILKNIFYEIPIRDALYDTKTKINWLKNTNQLLKITKGKNTLFSSNATCFTEIKRPMDIVKLLQSLGISEDQGHKIIQNSEECLKTCAFKRYCYRGISNSLEEGQLKRDFIINQFIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS76</accession>
    <name>A0A4Q9LS76_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1376p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001376">
        <property type="protein sequence ID" value="TBU11117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS76"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1376p0020"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="65365" checksum="46D3757B5E3D5994" modified="2019-07-31" version="1">MFIFKKVINTKNIFTTKKEKIHSTNKYDIYHSTINNQECSIFEYKKEKNYKNKIQENGKACKKQNKEFIDKIKKASDLLKNIKHINIIDVIKVSESKENIILYSKKVIPFLFIYTNELNEFNDYVLYKIGLVLDFLHEKCKISHNNIIIESLYVDFNGNIILGDFEEFSGAEMCSMNDDYMFKELVYKIKKSENIKNNEFSIKGYLNINEERFDKNFYKKFEMNFIKLNILKEFEKYEFIDWIIQNINELIEIYKKIIINFFVNELFKEYKVEYKMRVIKFVFELKIIEYEEYIEQIFSVLDSNIRLFILKNVDGRQIKNWTSNTINNISLGIKCNDNNLRRESINFIGKILYNLNDKNIKVVLKAMSCVTDKEIMKYILQFLNENIDILKSRNEDILKDIYKLVMTYISCEEVRKELLVTIEIFFKYFKLRKIYIELLPIICTMLGDEAIQDSVFDLIENILKFMKENKKELLVKNWNVKSIKGFFGFMKGNKEEKSSKNLTVINKKVIDEGILEKKVANISFQDKEKYNEEDEDISNEWNEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA1</accession>
    <name>A0A4Q9LSA1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1668p0010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="PITK01001668">
        <property type="protein sequence ID" value="TBU10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1668p0010"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="839"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="498"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="594"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="682"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="891" mass="105239" checksum="30827969EE327224" modified="2019-07-31" version="1">MTVKRKINENILKQKILSLTDLQSPSFVVSKIHEHQKEAIYLQMNEYKRKMEIYEKYNYELKTIMDLYEDFILFMVTNKKSSFSIEKLDFDRSGDKKEFVGEILDIFRNSISKRQETNKNKFEEINNEEIEDESEFKKCSSEIFEKGNNKESKDESKNKKISLEMLEEGNNKEQNSENVLNFDLEERQKENEMNIEMNGEESKDKSYGNNEGCGNIFEEENDKFQSKNNFGEESLICKDVKIIEENNKFQSKNNFGEESLICKDVKIKEETDESKLILEENSNFEKKSGFSLNEKNFNEVDGEKFISNGTKNVFEELNTRNTTEENGLNCCKSNLNISEILTEKHFEEQNSSLELQNENLINKNKIHENIKFEENPKKIKTVEIDVSDKSEDLNKEEIFNESFEEQNTNHKYDRISYDKKYRSSVGCNLNYYPLLPNSLINDLRNSVMEKEDLIYNLKKKNERLQIEIQKSKNIKKPEIEIKEGKQIEIDSSFFDKILLSENEEIKRLSCEILELQELLNKKEINLFDTENGSLKSKINILENSLANLESENARLVRESLIQRDEFKERLINREIKKTLNIPCDCKEIQNFKEIFSLKNEIINLNSQISTLKSEIEILEKEKQILKDFSDSLKFRKTDFSFLEKASENELISEIQSLSQGFDDLCTENNKLLEEIDSNIRVKQMLTNEIRTLKNKNEILLLQTENLENERNLNQKKIINFEFQRTQNEKTEKNLKIQIEDLKNDYLERKSAAFFHKRNFIKIYNENSILLSQIDTLKNKFTDLKNKFIQQNETSNKLQSTINILEKDLKNTKNLLLFYFKDSSSEIFNEIEKYKKTIICSACDTNPKNTVIVKCMHVFCKQCLDKRIQLRIRKCPICGESFNINDIKKIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC9</accession>
    <name>A0A4Q9LSC9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1341p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001341">
        <property type="protein sequence ID" value="TBU11177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1341p0030"/>
    <dbReference type="OrthoDB" id="420169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7162" checksum="C87DFB6D76DA07FA" modified="2019-07-31" version="1">MSEHSLIEATYLSQIDLTNGYYQIAMDTVDIKKIAFSKSIIHYEFLQMPFGLSGALRTFQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF8</accession>
    <name>A0A4Q9LSF8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1627p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001627">
        <property type="protein sequence ID" value="TBU10651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1627p0010"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="30036" checksum="9AFE280E0426E879" modified="2019-07-31" version="1" fragment="single">MKIKQKELEKSLLKANKVFRRSIDQRIYGREHETRKIKEFIETGSGILNICGNPGSGKTFCVLKVLKNTNFLYVNCLVEENIIEEINKYKGLMVVIDEFDKFYMNKKGVCVGLLNKLKERMCKVITISNYLLFCDCSVVFKPYSYEDFVFILSKKIEDEIGEEIVEKGVVEVISRKHSHHGDIRKAFEFILKLINKKSKEVECHVINKKGRTCKSKKFNLIHKNKISSKINKKNTVNVDNKINTVNVENKKNNEIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG2</accession>
    <name>A0A4Q9LSG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0027p0050</name>
        <name evidence="4" type="ORF">CWI38_1224p0010</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001224">
        <property type="protein sequence ID" value="TBU11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1224p0010"/>
    <dbReference type="OrthoDB" id="308728at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="697" mass="82656" checksum="499AE4A1748F179B" modified="2019-07-31" version="1">MEKKLIELENQLKSFILENLNGMTKQHSYFIFRNIKTKNGIKNIEKLIEVYEEAKQYKFVNLHLRSAFYLYKCISEEEISLRIEIIDLLLISDVSILEKIKIYSELKLEKECRSLIEKFKEENKIKTEIIGVDARLLKPNIRESAILFLNVESEEECCGKLSKKSKRAEFFTVCIKPLTIKEQIVLLAELEMFLFVENDELILKDIIISYLERLEYKENQKNIIIELNTAFYSTIYDISYESLFSLQKITAKNTKIPWNENIFEINAKFMIEKMRKIAKLNLKLFYFDAALKIFKDLKDLKNSIICLIGMGKEKEAINEALFKIKINTEELEKMQPNDKNRFFKKLEISDCYILLGSLTNNSKYYDLAYDAYKYFEPKKLKALQYFKNNDYENAVKCFEEAISVAPSNTGLLFSYGCALLKNNNLNRAVSIFTEILLKDEKHYKASVNLANCYFELGFHDKGIYILKNALKYNFNDSMARVYFLTSLKYRYYNECIFIMGLIKISESFIEKFINKLLEKEDFVLYNCDACCFLKRSKEEYSTDLNFYKFKRSEMNRNKIYENHGETEKKSSSFIKYNEDSLKVNKLADLLLKYATESKSLVYKYVLFIFSYRFQKPEIDLKKYGLEVFWDFFRENDFERCSNILLRIKNFQISNDVFAFYLKKFESHNTSSSYILAESEYSQRIEMLQNETGVTQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ9</accession>
    <name>A0A4Q9LSJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0718p0020</name>
        <name evidence="2" type="ORF">CWI38_1147p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000718">
        <property type="protein sequence ID" value="TBU01401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001147">
        <property type="protein sequence ID" value="TBU11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0718p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1147p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="113" mass="13674" checksum="43CB5D06DCA72661" modified="2019-07-31" version="1">MSDDDSNLFSTFLNESNASDIEKIMYQKKQKYKDMARSLADECNKKNLDMENYFHKRLESFQKKTICQKCKEFKDKSAETSIKYLQALKEISRLKKKNYELQFKNDYYTKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW3</accession>
    <name>A0A4Q9LSW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1245p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001245">
        <property type="protein sequence ID" value="TBU11367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1245p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="411" mass="44055" checksum="C9D0C3EF98C77211" modified="2019-07-31" version="1" fragment="single">PWPCPPRPSPRPSPPCPQKPCRVLRTIDGIIDCAKAKSKCAVSEASCRLQEHIVQIVLRGSGKIVHKINEEFDDVVDCLKFKLSNEAVAITSGALTCGNCHSDAKFDKKKGDSGHESLDETDAKVLNIVKRNSEILKNGIRNIINAESAKLTSDLKDDLAKMSSSEKEEALKSDGYKNIISSAVKNTLSNITASTNVLFENVIQNEKAELTRLYENSAAYNNIRGNLRDKPENPGNGTGNGTGNGTGNGTGNGTGNGTGNGTGNGTGNGTGNGTGGGGGSGNQGNNAFPNSSATAKGCSGALTCAKIIPGHRHAVIGLIESLRRKILCKIDHVIRCEIGQIKCAFKIYKFFLDRKLDRIIWKAGHEIKESVKDAFEEYCCKVRLAPPSPRFEIQDTKEENSPAFEKLADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY5</accession>
    <name>A0A4Q9LSY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1132p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001132">
        <property type="protein sequence ID" value="TBU11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1132p0030"/>
    <dbReference type="OrthoDB" id="2194483at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23031" checksum="028A43E7ADE4F867" modified="2019-07-31" version="1">MSDTYFKIIQIIEKYDDLERKELIDFYIETCGNEISCKNNTSKNTFILIMDLIKLAEKYNLPFERVKNVVLNAVELKVLHLRAIILDTIEIDYSADIESFYGCEKWMKNIIKDLKHTICGSKEVYTLFCKHFLEECLNVFVSGQNKFGFYGNQLIVNFIYFRKYISKFTDYNFQSFFETLISHFEENKFYGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT71</accession>
    <name>A0A4Q9LT71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chromatin assembly factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1041p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001041">
        <property type="protein sequence ID" value="TBU11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1041p0020"/>
    <dbReference type="OrthoDB" id="2193302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="2">
        <location>
            <begin position="440"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="691" mass="81336" checksum="284F264DB8E030E9" modified="2019-07-31" version="1">MQNHPFSLKKLLAFKKNNELENLKEILPYCLYLRLSYTYDDIETLFFDHVNTLLDKNQRIEIIKNVMNESMEWRFYRFEDSNIYVKSRPTLYHKNLNKRNNGGLWFLECKDIIILEEIFLFDVQKKRKNILEEYKFKYEKYKKLENSESGNLQMIEIDSSGNTDCKNNTEIEESLLKTESQNIICENNLDNKILEKTILEDQKSKSLDNLLNSNKEKEKSLLEDQKKKLLDSLNNDNIILEKIILEDQKRKTLDNSMKDNKEKEKSLFDEQEKKLLNKSSNNNKEIEKSLLEYQKNELLNKSSNNKEKEKSLFDEQENELLNKSSNNKEIEKSLLEDQKNELLNKSSNNNKEKEKTINNDQKRKSTSNSKSSQIKNNQTLLLFAKKENKKESTNTEFKGRFIPLIFDENVTVYKRNDPRFQGQFTLRKPKDIENPKKLTFIKFHDSIRPPFYGFKDKINCKNSLQKLSDSIDYEFDSEIEWEDTEDADDIGSTDEEEEEDSYSNNDWIDSNSESEEEGFIGKKPYLVFPNSIFLKFTEFDQNFLKIPLFEFSKFPEELIPLLKESFIKEEDFKEEDFKEEDLSKSDSSKSGLSKSGLSKSGLSKPSLSDPSINDPPLKKPSQNHPSLKKPSTNDPSPNETSTKDSPLKQIDVFKFAKIFSEKNYIKYQIVIKKIKDLFPEKFQNDSLDLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG0</accession>
    <name>A0A4Q9LTG0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0997p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000997">
        <property type="protein sequence ID" value="TBU11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0997p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="445" mass="52896" checksum="E4EC6FA7CE59FAA0" modified="2019-07-31" version="1">MDGIKNFGRKECHTGIFALYVLVGMMGVLLSYIGGMSNEKSVTVFMTKNSIFLICVFVSILFLTNLCFMVSMMCFLGNIVIFLILIIGPFPFWVLFLSQFRILHLIYLILPVYLFTSILLFYYRYCKYIGITRKYLRVSCIILMRNIFQLFIFFSLVFIIFGCVTVLLFYLICRYKDSLVKYIMFDSIIILFSIWSYFICSFLLSTLVSLYIYYKMSTCLADDGINPLYFTFRNIKNHLNDLFLLEFMNKVRDEDTDVSLVPIRHKLDVFVVWTFVGVICNCMECNINGMDSWPKYFMTFYFLCYFESKKHFKNVFKSINFKNIFMYNRPTLVLRTFQFIVFGLLLVCINSSFKMFYQMSIMERIFCLVFSFVFLDFIVVVEDSIWKCFVVAGCYDKELVDSCLKNSYKNILYVKEKYSEKLFGYLGRKKYFRTSPCMCWHIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS3</accession>
    <name>A0A4Q9LTS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0940p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000940">
        <property type="protein sequence ID" value="TBU12009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0940p0020"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="598" mass="69905" checksum="441C1E9B087F643A" modified="2019-07-31" version="1">MTIISKSFINFYKKNLALENEDFEEFLTFIEKPLPITFRLNTMSSSYHRLRDIVLNISLLKEILPNVFSLQISKNELRKNIKEMNLGENNKLGEENKFGEENNLKENKLEEENNFKEENNKLGEELNYEKNIKNMNIKDKNIEEEYKKLKDILVVQSEVGNLYRQELVSMLPVLIIQPTVNSKVLDMCAAPGSKSSQILEFVAKNWYENSRILKNKNFVKIFKLEENKGIVILNDVRPNRINILMKRIEHLQLPSTVVTQCDARYFPNLPFKFDIIYCDVPCGGDGTIRKCAELWKDWSVNTIFSMTKLQMQIVEKGLQLLENGGIFVYSTCSLNPYENEFVIQQILETKEFEIIDCSEKLKELNIKYRPGLTEWYPEGYLKPLDSPDTFLSKNNPELKKCIRIYPHDQNTNGFFICVLKKISNFTKQNLNKKTKKATNFDFLTEIQTTEIQNICDSNKIENIFSKNTKDLIFVSETLKEFLKNIPSNLKIISAGTHAFTSFHNTYRIKPSVLKYRYLNHLSPHQISKTDALKLINNRSFDLEELQKKNIPKKNIILQYKEFLFCCWIGENKISVFVGKKEKESVLQLIEMSENLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ5</accession>
    <name>A0A4Q9LTZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0945p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000945">
        <property type="protein sequence ID" value="TBU11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0945p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="25251" checksum="31FDF249AB7275D9" modified="2019-07-31" version="1">MGNKKSILTAIAILSLTVILIMCVIAHMEYKKGKKYFNDQILNFIGENKDKFEIDYEFISLNHIECMKSIKLCFYESNEDLSNIEKLFKENVDFKKITDKLDKLKIVNESELPIDALIDKFSFSNNFFSRLGFFMYDKNSPIMKLKGTGNYVFNKTDSNTKYQIWFFILPKNKNVEIYVFTLDKKNVDKNNFTINNFENTPENVKKHLTYLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU01</accession>
    <name>A0A4Q9LU01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0890p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000890">
        <property type="protein sequence ID" value="TBU12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LU01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0890p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2074"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2082"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="2324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2324" mass="266657" checksum="AFEEACE09FDB8221" modified="2019-07-31" version="1" fragment="single">MSKQTNNLNFLKKAFPSFFTKNMLRKLQNKLIDLNKLSNTNTHTDTLSDTNTQHNKDNLNVNNIYKNILIITENEEIKDFKGILPVNSFFIYFDENTFITMNTDTPLFNSVKSIILGVNNITPLVECVEGCYFNEDTNYVIDRCQNNKDVGKDMLNELLKGINISTPNFIESCQNNKDVGKDVLNELLKGINISTPNFIESCQNRNVALGKDTNISTPSLIDRCQNNKNIYNNTVKDSNISTPSLIDSCQNNNTPLSKDIYKSSDINTLNYIDSCQKAYLNIKNLYACINETRTSFQEEKIFWKRFEKTNQILISHYKQHIEPFIPLLESNNQYILANSLKTHFNTSYYTLLSNTFNTFYSKISFICTTPFDFFKTILTLKDSLSLTPLIIKKSIKAYLKPFIINTQRILIITLRNNTLYIKKSLKYLNNTQQILLTLNTLLDERLSINFIIEIYQSFLEKDTFILLIFKTLYLLTRNTYINNRGFNNYSIIGGVNDKDSMVEGVNNKDMIEGVNNSTNTLHPFNTHTDKQQGVRYTSIKQHPVNNTTNTLHPFYTHTDKQQGVNNNTDEQDPLLCKGILKLFKRFKYSKGKFIIENYLTLNYLLYKKYKCKEKYCLTHLLLFSYSFEMKKVERRNNRGVNEKDMSEGVNKNDILEGVNNTVGKREGVKYQDNEQQGVNNHTNEQHGVNNHTNGQQGVNNHTNGQQGVNNHTNEQQGVNNHTNGQQGVNNNDIQQGVNNHTNEKQGVNNKRYRNNKKDYNNIKKRVLNKLTCIYIDNIKEIIKKKIFCNKKVCYVLSWVLKDEGVNTESLKYRISILPLLSSYISYGVTEGVNDSKWDINNIKGNDNIEGVNNEDSNANTPLSTCNSIHCINTPLSTCNSIHCINTSLTTTLHSYIKSNNNTRRIHLFVNKIIKTFFKRNTLLEVKRVLEKVNINYDCNSKIEEIIRILQYIKGCYDLEALIVTNENKIEINFNENLFEIKPLIEIILSNFTYKSKVGVIGSVLEGVSGVNDSSNGYRGVNDTSIIEGVTNLCDNQQGVSNTMNKQHPFSNTTNKQHPFSNTTNTYHPFNNSTSDNTGSIKYPLTENIFNKEDLKEFTDIQYTFYLLKESISTFNILCKKIEKYISINTSYSYFENELEGVNNSSNTLHPINHCTTYHPLNHSTDKQHPVNNSTTYQPVNNTSNKQHPINNTSNKQHPINDATYHPVNNTTTYHPINNNTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTTTYHPVNNTNTTNINLLLEKAFFILKRLVYLKWKYLINNTLIDTFIETVRILEEKFYFLDFLIKKMNKHFIRIFNTQITKNTLSFSFNPLYYIKYFPCYYDTSIVIRSIEISFIKALFQYFKTIKYSLVNKRCYLLKSVHNICLDTLFIEPSLEMCFNIYSVIFKGSLLTKIYNYYRGVKGNDGLEGVNDKDGFEGVSDRDEGYRGVNAIGGNIMGVSNNVDEQQGVRDKDEDYRGVNYTGSNIMGVSNNVDNYQGVNDEDGLEGVNEKDSLEGVSNNVDNYQGVNDEDGLEGVNDIGSNIMGVSNNVDEQQGVRDKDGFECVNEKDSLEGVSNNVDEQQGVSNNTNKQQGVNYNVDDYKDVSNNLYKQHPLINTLIEEIIELVLMGYLQCKDNIEFLRNEVLFNYSYFIEVESQMNKILLKDKSNDNTFTTSTYTPYINTPLSSNTHTLYSNTPLATSTYTPNINTPLSSNTHTLYSNTPLATNTYTPYINTPLSSNIPLPDILLIFLKGVNDLRIILDYLSYINKRCYLYNLINNNEIPLFTFKILNNKISIKECYKNKNMFINRSVNTFIVIYNTLESILREITYEPYNLYVLYDLLEIEDFIYKISVIKEVSSVIIKEIKSGVSHTRDIVEGVRGSRDIVEGVNDTSSKLEGVSYRRDIVEGVRGRRDILEGVRGSRDIVEGVRDKGVLEGTKGVSYKEYELEGVSKGTDNYNPVNNRSINNNILTDYTHVLFINKYNTINTLLITISNRIKKEKKRYFDLFYNNSSNVDNINVNDNTPLSNSNADNTPLSNSNDDNTPLTNSINPNTPLTNSINPDTPLTNSINPDTPLSNCINPNTPLSNCINPDTPLTTITTNNTPLPNTLPTINNTTTLSLPYINTLTFNTTTSYKSIINTLFTYNYNTINNTYEFLYKLKDNLLVLEYKYLIIKKIRNFLRLEEYLLIYRNIDFNTLKYFIYNIYSFIVNIKNKEEGLNEYENNSLRHVSVNYMKGICSDMYKEIKGMGLVLDSGEGVSDNRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA8</accession>
    <name>A0A4Q9LUA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit alpha of sodium/potassium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1259p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001259">
        <property type="protein sequence ID" value="TBU11341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1259p0040"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="22927" checksum="3A1D31F4F5E3B441" modified="2019-07-31" version="1" fragment="single">MKHTTKETEKTMIPIPQTSENTNKEMSKMDKTHIPMEQTSHISQTQSKETNEHTISLEELFIKYTVDPDKGRTAEEIETAKLNFGENTFSKPKKDFVGLKFFKIYFQSFNILLTIASFMSFTIYLLNNKLILNLYLSFTIIIVCLLNTLMEFYQEYKAAEIIKGFNTLVPQKARVIRNGVEEEIFASEIVVGDILLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD0</accession>
    <name>A0A4Q9LUD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1339p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001339">
        <property type="protein sequence ID" value="TBU11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1339p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="781" mass="93063" checksum="A96D1462EBB6A12E" modified="2019-07-31" version="1">MTIYIKVFKKSNVYMKLYAIIFFIIQFFNTVLAQKTVAIHFYENTDSTLKENFLENSQSGIFQATLYKKYQIFSAELSTEYQKTFLIDLDTFYLKFSNEEEILDGKTYNIYINNSLLSYDEFTYFYNIVMSFPSFIDILNEYNYRLIFTIMNIFKFKHDKYFKRFIRLLWVSVVFNPIAMENWYSKISTKNKYEYPSCISKIALVELLKLYRVSEETLEKIEDTSYLLNWTLSFKYDFMNATDEYLYIEPNIINEILNRSKKSKFFPELLDTFFSVHKFKNLFLYNISFKEEHGYIFNLSFFKYNESLVLLFCSNLDILIQKTYQVFNSDCLKAVNIIYSKITTEDEISWLKTQNFKSINYVVDKWESIFQFSITEPTSPGFDVLLNVVREFFTKENNPNIFIHDKIVSCYDFCKTKDLQIYADQSKVEKYHKPGFPLQTYIFIQYSIVYLTLEFVIINFKALKNIYITFTDTDIKDFNIKDKEIIENIVNIQFDRSKVYFNFLSKILSFPSLENLKFFKSSIIFTNTKINLNENQKIECFIFENSSVSHQNIFVELINKMIGLKALDISFSKKFLNPFISISEELNLHLDKLNYLKYHDSESLNYNLLNFSSFCCLSVFEFGSELSSNYPEGTLKEILLNKNFKCVLMLDINSVSVSEREGLALEKCKSLQYLKFSSGCKVSKISFFELFDSNSFYPLIELKLPNFEFTDKDLFFISKLKFLKKIFIKNLTIKTNVLYFLKTFSLFQEIEIYENFVCKKNIMEMFGTKFKHIKFRHQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS0</accession>
    <name>A0A4Q9LUS0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1259p0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001259">
        <property type="protein sequence ID" value="TBU11340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1259p0030"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="12">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="13">
        <location>
            <begin position="347"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="56582" checksum="B3ED5D4F491AA0D0" modified="2019-07-31" version="1">MLSLEDVGKKVDEKEKFKIYKKIIEKLNYPFIETLYAKFFGSHPVTLSNETIELLINRDYYVCEKSDGIRVLLYIYNDNKFVYSFFFDRKNDFYLVNINNNIKIGTYLFDGELYNDFGKNSSEIVFSIFDCLIYEGNDFSFQNLQKRLELCQNFINLYKNVDGFKKYKFKIQVKQMFKSYGFYQVYSEIDNLAHKNDGLIFTPVYQPYVFGRCYTLLKWKPPSLNTVDFLLRKNKEVKNCYELLCFGKNNEMIIFDHFFDFEIEEDRGRNVKESNKIKESNINMKNDLYRGEKDGERDGNQNIIPEDKNKGDMKKDKEDRQRDGNQNIKQEVKNKGEMKKDKEDRQRDGNQNIIQEEENKGKINQNDEEFERKRIKISQDSRIQDKTEEVYDGKIGEFVYLNNSKSIDLNDLSIKDGAWSLLKIRNDKNTPNSFKVIINIMSSIEENICFEELTKYFKNIKNGWNYRILNHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT1</accession>
    <name>A0A4Q9LUT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0764p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000764">
        <property type="protein sequence ID" value="TBU12419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0764p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="26932" checksum="39FF7580DBAE25A1" modified="2019-07-31" version="1">MLISNSTINGSILSLILGCNFLKTLNFFNNAIRFDINELKVDCNTSISKLIFYSKDTLNAEIFLTFVSFMRNLESLSLTFFNGLKNLYLNVDSEISTFNDLYFIQYFVVTESLVFRLKYSRKFQNDFFDLLSDDLTHLNIGNLIFDEENRRVLKNFKNLSCLRIFNGSFKMLHFNELFSSCFEYKLAEIDLNYINITIEDKLFMKKLTHLKKQYFKNLISFWIRICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU5</accession>
    <name>A0A4Q9LUU5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_1154p0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="EMBL" id="PITK01001154">
        <property type="protein sequence ID" value="TBU11531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1154p0010"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="48"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU11531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="39819" checksum="95FA97A867E0DB85" modified="2019-07-31" version="1" fragment="single">MLDMVLSSKDIQSLKRMTVRQILLQFTSACYSIMSTYMVWKLFSIILNNDSPIVVVLSESMSPGFERGDILFLKPFDYTTGDMCVFQFDKKEIPIVHRAIKKFNTSVLTKGDNNRYDDVSLYRPGQRYLNKEDIISCVVGYIPYFGMSSNLKWKGMLLAENKLGAKEHALLNIALNKEYDFNLKATWFDILQRDSPSSLLFVFCIDPLSRKPNKKYTKVTVEIDTNNEKSATIDTCYEDTVTLLEGFIFRLKPADFSKLDDAVRARLYLSRTKLGRGLHSVELRSEHMLLQLLDCLEKSKKNQLDEQQSSVENNYKTHLALIKGFLKVKYRLVEEITKKSLEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV35</accession>
    <name>A0A4Q9LV35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0838p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000838">
        <property type="protein sequence ID" value="TBU12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0838p0030"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42951" checksum="0C22A9AB97FFC8DD" modified="2019-07-31" version="1">MNTQKWSSPFIFNVWSDTTEEWTDQDWRVVGYNSRSRSKSVTYEECKDQDWRVVGYNSRSNSSKDSIINKYTNTYSNTNNTYSNNTYSNTNNTYNILPQLRRLSEPVITNNMSVSDILSLNNNLYIIEFKGGRLDVGYFTGDTDRDTNRDTNRDTNRDTDRDTDRDTDRDTNRDTNRDNDLYNSNRDTNTNQLNTNQLTNQQSNITSHFITNAYVILEADRGEDLGKIKCKTSKEKYKRLLSRIDKNESVREVHPKRIYRLAEGKDLEVIKIKEELERNALLSCKERVRERGLGMEVVECEYQWDMNKLTFYFKSDKRIDFRDLVKELYKVYKTRIWMCAVEKGDSVVWSDGNKVSISNKYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWK9</accession>
    <name>A0A4Q9LWK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0901p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000901">
        <property type="protein sequence ID" value="TBU12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0901p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="491" mass="55786" checksum="BC2F6793EEB48712" modified="2019-07-31" version="1">MNTTKINIMKRRVDILIFIYFYLNLTILKEIVSVADPETGNILSAETLNMVDGKDGGKENETFTRQVVSMATGSPPMNRLLTSGQVVHPSSDNSGLAKIDSEKETDPEDLWSFIPIRGNKVLFVGKENMCLKRNGAQISLESCPKLDKIVPKEFEWLINIQISKEDYDRCKTIVSEYEKSDGGLGGVFKKNSKREPSSDKSAAPGSQQSEPSGNKPTGDKYGDENRQRDMSPDEYSSASIHKPSDSYRPDSNSDKPSNINKRKYSGDKPYTPADRNNQENGFPPKEDHRDNNDNPGDDYSRHRSNGYREGNSRGKYSRRDDDKSIADSQYGDGDRTRDEYLRDKNDISQRDNTLEPRNQPRGSFPKETDGQRDNHTPKDQYRPERDDRLPHHSDREDDIPREGHSISPKNDRYGPPDNYSPHIDQERNSGKRSWYHPSRSEAAYSGRNSKKSKTSGELDTPIDNRSKDENILSTLEALKELFQEYGDSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS3</accession>
    <name>A0A4Q9LWS3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0229p0040</name>
        <name evidence="12" type="ORF">CWI38_0815p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000229">
        <property type="protein sequence ID" value="TBU03807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000815">
        <property type="protein sequence ID" value="TBU12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0229p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0815p0010"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU03807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="469" mass="54210" checksum="B9FF2ED3906AB063" modified="2019-07-31" version="1">MVQSNLHTWLKAAAENKITTKNTWKSNIIEYLADVNQFIENNGLNFQMASSTLDGAVKEFSTRVDDVSENTNKLLEHLDDEIDSDGKDNTKNRQRSKRQNFIEKDVENLNIKLSEQINQTKLFKISCRKTAHRLLLDYIFISSHGIQNLSLDENIFDENVILETKEYPLNLEECDFPICPSIKDIQNHSVKRISTHYTGLENREDLIENKAENVNFENDFQNDFSTEFNNDFNESISETNNPPLITSSNSLNAWAGPEHWKSSISKKTKARKPTQKNLLNFSIKISTNILEKANTIFDASYISRRREDKPLLPNDYKINTEDIYKYAVREGSFYTNNNLEINDTSICGNITTNTEITAVSFIKEDLKEEIVVDIPPTERKDIIENLISKYNRTQKKVDIKKLKDKVYFNVEKNKIARLSDIYSEIKDSYDEIEKKDISVHYCIISLLHLASENSIDIQSGDNDILVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX06</accession>
    <name>A0A4Q9LX06_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0825p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000825">
        <property type="protein sequence ID" value="TBU12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX06"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0825p0020"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="534"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="76545" checksum="2B3AED5CA4F8B8D1" modified="2019-07-31" version="1">MTDNTIPREEKKYKSIYKDLDVKRSLKVIWTNKCKKNEENKYYVSDRSKKSVCIKTKQEMAKKLEENNTFDFSCIHYAADKSDVNFIKENIFNVNLDIFELIMDRLEKEWFFFQQNLVNKVYVPTEYAAHVCNICGKSDSKVGNDTIFCDGCDICVHQECYGLPYIPEGTWLCRLCLFSKKRTPSCKYCTKIGGALKQTADNRWAHILCANWIPSLSFVNTVFLEPIEEIGDELRKYKNSFCIICEQRRGVTIRCTHMNCDISYHVTCGMEANYYFDQANFISYCKNHDPRKILSLFSFGKYRQSLYPDLKNIPDIRPHVLLSLPKPSFIIKVKEMKPILCNHFIDRILSNDLCNIEIETKTVETIGMWWMLKRSFIRRMPLISFLNFEYGSDFGHEWFKNRKLFCYNRFSLDYYKSKGVFYLNDMDLDEEKSEGEIKNKTITDNQDLNCKENESEGFVNSNVKYECQHKAGYEMKEETLKEICDSVVILKELLYNLKEYYHTRSDLTQHNLNLFEMYKNPEKYYMKEFLLKLREVTDFFWFEEPVTEIIAPKYFTIIKNPMDFFTIEKKINEDENYKYKLFLKDLKLIYDNCKIYNKNEVYFQKLLCQFDSVVNELNLKYKEIIYEKISLKSLLEYLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX51</accession>
    <name>A0A4Q9LX51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0807p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000807">
        <property type="protein sequence ID" value="TBU12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0807p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="11963" checksum="9E6CC068B654B266" modified="2019-07-31" version="1">MINTCMWKSQVKMKRSSNIGLRFTGSEMKSNGKMDGQTREKTYKSKEISKQINEGTNSKKFINDNCLLLDTNAALFQIANLKINDSSEISESKQKKPEKLANNIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX68</accession>
    <name>A0A4Q9LX68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H2A/H2B/H3/H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0453p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000453">
        <property type="protein sequence ID" value="TBU13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX68"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0453p0040"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="22450" checksum="7F624076BA1F4242" modified="2019-07-31" version="1">MTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKQASRGEDGEEPPININEESDLEEETIEVEETARKSTGGKAPRKQLATKAARKSSVAPGTVALKEIRRYQKSTELLIRKLPFQRFCRAITQQFKTDSRFQASALASLHEATEAFLVGIFEDANCCATHAKRVTVMSRDIQLVAKLRGRELKAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT1</accession>
    <name>A0A4Q9LXT1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0724p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000724">
        <property type="protein sequence ID" value="TBU12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0724p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24851" checksum="54CAC115E54D5DF5" modified="2019-07-31" version="1">MEFLCNVSIRYFLENSIFASNDIKFLEKSEISFYRFIDNDEANIGIFLLSVFLVKDSIEFRSNCELGKLKDKFSYDGYRNLKSLKIGSVKINETALNVFENLRSLESIELHPNQHIHINFSELFSSCVIYNLKFIILREMRILNDDMLFLSKSKNLERLIFDKCDFSGLSYLTLVKNNFMSLKILKFLTCHYFSSGGLHEFLNEEYSVNILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT9</accession>
    <name>A0A4Q9LXT9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0721p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000721">
        <property type="protein sequence ID" value="TBU12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0721p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15572" checksum="059DFF0829E77E0D" modified="2019-07-31" version="1">MNDYIPAMKVQIIIQNLSRPEVFEGNSKEENGKEEPKEEDIKPEEKEEIKDENKDEKKDEDKVENKDEDEEDEDKSEENDNKKEEDKEENKEILTSDEKTLNPATEDNQIKDLNTKNQDDLPAADQSKESATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV0</accession>
    <name>A0A4Q9LXV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0373p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000373">
        <property type="protein sequence ID" value="TBU13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0373p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="840" mass="97952" checksum="10B5009A3DA32C43" modified="2019-07-31" version="1">MTYFLISVYIERFNCIRITIHFTDDYFMNSMLSSRANSYNSTNSYNKPELDVGYNNNLVCSDSNTKFTSIRTNQEDNSLRYQNVNGDTRMESKHDSINASLNVGLNNNLYYEETIYQKNTQALKSASIRESESFCIDESVDKQIPLLSPNDSILIFDYSYAYMIRSRYFDSLIYSGFTEIILNIKNITKSNIDVIMCKECLNILCYGLNYCILGLNNENFLDFIWFFHDLSCYSESDALDIFYKNLLPFLFSYIEDKSSPNVFNMKDSDFLKYRNIFLPFLTASYDTIDIFFNINTKELMFIEKKGIRKFNLFGLDITEEIVIRTTPKALFLMQNHQINYKQFFLEKIIGSFRIIGMRISGDDIYYSEYKDSEISCSSLKNNSEICNMQTSFCLIFTIIAHKTNEIKLIEFERILLSETDISTLKNIKNLETLILVKCNSEKFADFLRNTVQIFGNLRNLQVIGYTLDNGFFKLIHTTNIEILDLSCSRYGGSTTTLTIGKMRTLEEFRINYSNLNSIILESIIECNSLKVLRMRKISFSKSEGFKNFDNWRKSYRILDISGGIFTDYLLKFFLTNIYCEILILENFCSLCDLIKILDQKSLHLSTKNLNLSKNLISYKVFKVLDKFENLEYLNISNLNKDSLEFYCLDLLIPPSSFDINPNIILDKDNCKTVPELSPNYMQEKYQSIFDYKTGFLECLCATGLSTFLKGINISGNEIDSANILRLEWFLNLDYLIVSFNDRIFSDFLKEYGALKCSKLKTLVLVSTNINNDIYYFVMTLPLLRNFELRECKSIDEILTSNLTLYPMFLETIFVINTEVSSHYRIILNEFSKRGISVIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY04</accession>
    <name>A0A4Q9LY04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0629p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000629">
        <property type="protein sequence ID" value="TBU12791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0629p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="32461" checksum="6958815C98E9485D" modified="2019-07-31" version="1">MWGIMMTNIICTGLGSLFIYMNREYHGSLKHIERDINMWSENKQFGMFFLYLIVFIGYFTTVIIELIRDITLYRGYRERRGGRECIRSRESRSGKYSWLVQWKFFRIINFMVVPVFVSELFYYFRQNGISIANNTFGGFSGKNMKYPDLIIIYDIIGILIIQYTYLVGKNIFILKNYLKSRNSRNIRNYNNQNSRDNKKCKKTYVFMSIIYFIGVTIHLIIFMLGFLKVVVVFSVEFNTFCLFCLTTVLYCIVFLFIEKYTVDSKIYNEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY58</accession>
    <name>A0A4Q9LY58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0344p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000344">
        <property type="protein sequence ID" value="TBU13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0344p0030"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="475" mass="56003" checksum="319EB2EE05277A5B" modified="2019-07-31" version="1">MGIKKKVDSENIKNEKIKAVNKSENSAREIKSCDVDDTTISERLLSQPNIHKTNYQANIARLVFQFTLDSFKAAEQELPRSDLYSTTEIYENAQKWLVCNSEKIGDEVLSASQTKSIGEIMRVFNLDLSKTNDLSETLYVKKFRMNGNRKKLRRKNRKFRLFRGRYNRSEKIYEQYRIRNKQREIKLRNLFQVINQHAISLLNFHIGVFLLELVEFSKFDDAVLCKERLYLLTKEFRRILHSVEFKNENMLSQLLDYLKKMKNTNKSLLALIKGFLKLKYSLTCKILNEIEKRNLHSKIYNARKNKLVSISDFSRLHDEAVFCYIQDRNAFWGDDGMCQQCKQSRKTLDHLANRSKKMLGHDYTRRYNEVYDLLANDFILILCVQDGEYSLYYLKRLQILINVGAYIQFIVIKKTAETIYFDRRRGLDVISGAEMHKQPSFPLKEVDNEVFCEPTTNTNVGLELEEEIKVVKMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG5</accession>
    <name>A0A4Q9LYG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0328p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000328">
        <property type="protein sequence ID" value="TBU14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0328p0050"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="11156" checksum="C1AEB78F4C639AC3" modified="2019-07-31" version="1" fragment="single">MSSRNFLVQPSELNHIIRLFNTNINGTSLVTHALTKIKGIGRRYADAAVKMANIDPSKRAGELNNEELNALQNVITDPLSFGIPEWFLNHQKDYTDGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH7</accession>
    <name>A0A4Q9LYH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0308p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000308">
        <property type="protein sequence ID" value="TBU15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0308p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="355" mass="41527" checksum="7AE7608C2BF8DBAF" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKLKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKKGNINPRNETVFCYIQDINVLLGKTVDHLETRCEKMLGHDYTRRHNEVVRFQEILHNEYTEIRVDTRIKTDVKIRNNRPDIYILDKKKNKITHIEAGITSQDSLQIVETEKLRKYDLLANELGLVYKCSVEIIPYVMTWNSIVTKYHKTYVKRLEIPMKVEAYIQSLVLKKTVETISFDRRRGLESGLNAEESWERASISVIMRAEMHEEEDGAKYFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ9</accession>
    <name>A0A4Q9LYZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0255p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000255">
        <property type="protein sequence ID" value="TBU18013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0255p0030"/>
    <dbReference type="OrthoDB" id="2190805at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="35894" checksum="E413771861871B4B" modified="2019-07-31" version="1">MMKNSDLNESTNQSNIIQRIQHILKETDIIKQKYECLETIIIINSIDSIIIPKLALNMDFIKFLQISYNLLSEDEEYKLYLEILSKCSLIKSKMDEYNLWEYIEEMGKKDVFFEKVVHIKNQACINTSEDNKHVKRRKVGKRVSWSENIAEVKYIPVVDSDKPFRHGGYREKDYREAVVMKVDRTSNEFEDFLWYKPHKLDLENNFIPKVESEEIKIQAERESKNVEIRNSTEYGNKFIPSEVFEEETISNETIEIPIFDLRQKNKMTELNIGNIVLHTNELKITIDEVLNDPNVLQSIFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ08</accession>
    <name>A0A4Q9LZ08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0404p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000404">
        <property type="protein sequence ID" value="TBU13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0404p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="13224" checksum="1D884714E0071CD9" modified="2019-07-31" version="1">MNLEAYIQSIVLRKTVETISFDRRRELESGPNAEKSWERASLSVISGAEMHKQSTPPLKQVDNEEDGVKTENTKNILPLILDGITTAKEPTIYTNEELELELEEEIEVVEIVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ34</accession>
    <name>A0A4Q9LZ34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-alpha-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0367p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000367">
        <property type="protein sequence ID" value="TBU13666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ34"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0367p0010"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="18893" checksum="797956A38C177A06" modified="2019-07-31" version="1">MVEIRKMNYSDLESVQEINTKNLPENYKMKLYYYILTLYPDLSFVAVENGLIVGYILIKLEKEDLDINLAYITSLCVDFEYRNRGIGKRLIENGIKAVKNYLKENMSHINSINLILNVRVSNNLAINLYCNKFGFKNTDLIEKYYHNKEDAYRMVLTILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ55</accession>
    <name>A0A4Q9LZ55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0362p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000362">
        <property type="protein sequence ID" value="TBU13686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0362p0030"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18690" checksum="3AC2CC12031AE209" modified="2019-07-31" version="1" fragment="single">MKVKKLLISLIAMIFVLVIWIIFIISSKRKDIEKVSAEKNRTKVSEDTLLLSERNFVGLENDKYVCYFNSIIQALYVQTDFMNKIFSYKHNQNQKCIILLKEIFSLMLKGQIISTSNYLKQILDLNVDYKSFKFGFFEDAYACLSIIFTQILNEINDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL1</accession>
    <name>A0A4Q9LZL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0217p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000217">
        <property type="protein sequence ID" value="TBU19276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0217p0030"/>
    <dbReference type="OrthoDB" id="5549358at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="293" mass="34387" checksum="AE3F0E439EE4A11A" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRKGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDVEEETIVVKELVQNFIANDMISANTTFLHKEMHEFTRAGPSRNEKSIIDYIMVKRSDHKKPRDSRACDFFETTILNIAEAVCGKYKSNGKNFKPTRWWFEFINTEIKEKKTSFWKKIYQKIKNSYTRFYEMRNTKDCPLKFVLSKERELLGYEKRVMAKKREYFHELLNSSLKDRKSGINNNDNKPKNKENRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW7</accession>
    <name>A0A4Q9LZW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PHD-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI37_0319p0020</name>
        <name evidence="16" type="ORF">CWI38_0283p0040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FI-OER-3-3</strain>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000319">
        <property type="protein sequence ID" value="TBU03289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000283">
        <property type="protein sequence ID" value="TBU17617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0319p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0283p0040"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU03289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU17617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="185" mass="21175" checksum="CF3728440FEE826D" modified="2019-07-31" version="1">MLLKTSLDTLEEIPIQIQQALTKLKETESKIMKYQEEINNKLSKIENDTSDTDKDLNKVNSALLNIYKHEKDIEVHLSHLHMVLDEQMCNLEETCENFKEIVCKTAIPLKNNRITGAFGVSRTNQSEKQDIPYCYCRKGAEGPMVACDGPECSLEWFHNKCVGLKAPPVGKWLCKECQEKTVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ8</accession>
    <name>A0A4Q9LZZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0408p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000408">
        <property type="protein sequence ID" value="TBU13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0408p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="21095" checksum="A692E3B30143DA1D" modified="2019-07-31" version="1">MWFIKESLSDRTLVTVYTPSMNQQTRRFRIMDCAYDKDLDMRTDLENKENWDEIAKENNTKAIRKNMNENALKEECLNQYFLKIHKRIQEKRLQDTFITLISDENDHMSLKNLLNNWNKKPKKQVEHHLEEDNLVLKQLPPPKSNIYTKTGNRLNTESGINTYTCFVDLEKLFYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B2</accession>
    <name>A0A4Q9M0B2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0412p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000412">
        <property type="protein sequence ID" value="TBU13500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0B2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0412p0010"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1011" mass="117416" checksum="32D4108D5553E3EF" modified="2019-07-31" version="1" fragment="single">MYGEVGDKRVLYVWRGVLVNKRVLIIKVGDKRVLYVLRSALWNKRVLIIRVGDKGVLIISQQNKMKKNEGENTGKNLYPEMMQYKDYQHINDKYRFNESVPPYYYQKKEYCDEYNDYPYEYVESDGKRKYSRGPRMSCPAYVDLGNTDDRMDINAMRIVWKKERNRLAAKKSREKKAGHLKELENRERRLGGELQDLKEAIIDYDNVLRELIVYLENAIDSTNRKQENLILLFDCLCRLKKPNGDTGIYIRDVGDIIEKDLSISNERIDAITSKIRASLNDLLCKNKLEEAQLANLYNEIKSRKLHSKLYSARNNERVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHNEVLRVDTRIKTDVKIRCNRPDIFILDKRHNRITLIEVGITSQDSLQIVEIEKLRKYNLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRQRGLESGPNAEESWGRASLSVILGAEIHKQPIPPLKQVDNEDDDVKKENTKNILPLILDGITTAKEPTTNINEELELEEEKNYKTIKTYFFVINTQKDENTMKFIFIYIMVVLSTLKNKKECDSKQYLNKVSQKDKIMKNVVMNNAFRMRKESNDLKEIKEQMKVRESYCFSLKECEDKLKRNKNLLKRKNLLIVNLTTESEIKNNSGNSGSICSIGNIGHSGHSGISGSIGNSGNSVNIVKSDKLKEQKKLNEEISKLKKEKTEFLLKKSEILYSKICATRKIIELSLYFIKNDKFLCKFGDKDISFIKTLRGRYEEFRKECDCDNEVLQTSVQELETLIQNKSILRDEIKKETDFDNKSKLNNKSMNDTSGVVVETNKLDDLVEFDGELDTDLLSNEKIPISPGKFLSSTLRSEESDLEFQSAKENLVSLKPQPIHQSISNEHLNTSLCNPCTSINTENNLRNFKDKSVSTTNLCQNKTVFDNSFRFGGSTEYCFEIKLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J6</accession>
    <name>A0A4Q9M0J6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0120p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000120">
        <property type="protein sequence ID" value="TBU20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0120p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020641050" evidence="1">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="26794" checksum="2018187D0E9BF724" modified="2019-07-31" version="1">MISVIISLLILIACIIARNKSENITVIFKKEYRKSSESFEFNLLAEALKVHKVSAFIQKGFSKKSFGVIYFDNDEAKNKEIIDKLLKSLDSKDKESFPVFTPPRMLFGCEDIDSVSFSKIFGNISVLTRVGFWLKEDPILKTLREITEFIENNMSKISDNGWKYVFICTPDDKTVKLYDLAFPGSGGYGFGPSKEFKFELDNAMNSNAYKYVSFLIEKITDMKSQKPKNDDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q3</accession>
    <name>A0A4Q9M0Q3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0369p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000369">
        <property type="protein sequence ID" value="TBU13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0369p0030"/>
    <dbReference type="OrthoDB" id="2189356at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020758030" evidence="3">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="34385" checksum="4CA18870A0C664FD" modified="2019-07-31" version="1">MKIFLNFYSFFYILFTTAIQPPPLYLSHTMEDSSDNTTYSQDTFEDNEIEKITPDYSSIPRYKPYSGDTDDKEYNKGSKLSQKYLPFNKNTNSFTKPNNFSSKFFNKNLMSKQFTEEKVQGKYDMPVPSSDPFESQDKPEYSLSTNLENEKSLNSHHSLHKSITQGKVKTSPKNLTNLLHHEFDDVSVDLNNKITNTIQNMHSPLFDPHKYKEVIVIRKRILQDGKRKIVNLNVSEHVVPKEVIQSEEEISRDFGLRALLGGIVFLLAGLVFTSTVKMYQQYVKKRYIKINSEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V7</accession>
    <name>A0A4Q9M0V7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0099p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="777" mass="92077" checksum="39612B9942FA4A86" modified="2019-07-31" version="1">MICIQKMEKIQINRLTNFKYVINECFKLIFTEVLLSFLYKIIFFICFSCIYCSIIISYPKEINIEETVLLNPKGINEAVFGIKINDFVVDVCDGIHHLENGKLACSLNSDQHFIFTRIEIDYENYCVLTSKKIQNHILKYTAFEVLKINHVGLLDLTFYLKYISSFDSAIKCFTIKEIYSLFEWFEVFEIQTDNVEFEDCMNFLALNLLESLSKFSPVFYLHKEKFTEYFYSLIFKFLSSIIYFCFSDQRKFLAYENDELQIHNNDRFGSADLTLLCDQSFFDFLVEINLHKLYFDCILDFLLLLEIHTIYLLQNFFILTDICYKKLITIFTSIKRLKIFMNDSEICSMIDYLVLFEPFGNITELYIQASSEQLKYFSDFFFLFPKLTLYRINFTDAGLDTNFIADNFTNINVPTEIQFRLLTDFVYFLSKSKNYSQFLALKIDINANFDIKYAYKLPNLSVIDSKISYIGIRDDNIEMGEYISFINNLANLKELRIECKLTTFNKFDFSKSFEIYNRLRKLHFVCVYVVNSCKDFFYNFNNLSNLIIESYTLLRRIDFDFLKFKNGFNHSIQEIYLENIAVSENIYQFLKNNDTLKVLSLHNCNLASDFFEILSISSTKYQIRQLSVKKGNFNNLQLNFFDHFPYLTFLSLLQCKFRKLFPGEPINSTKIKIEFMAFSISCEACATSFGSLERFRNLTTLYIQMYPTSGFFNLEIFFPKYFSPKISILKFERFCINAEILNPLYQIKSLTRIVFLNSFFLNDIKKISELQKFEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F9</accession>
    <name>A0A4Q9M1F9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0059p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000059">
        <property type="protein sequence ID" value="TBU20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0059p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="53836" checksum="96FA8DA5A0BF4A27" modified="2019-07-31" version="1">MKLLKNKDLFICTKSLKTLKLTCVFTTEELKIFLEHCSNLQRLKICTDLLDFKQLSLLIDFSNKNPKVFSKIFCVAFDSVTTDPCLVKPIPENIVIYLENIQIESNFLEVPTIYKPLFIEYFYRFKYTKNSRFLTDAVSFDISKSKHVTLNFDLYNSPFELDAFIFTLLRCFTSIQYFFLQNIVISNELMSYVLESNSITQLIINKFVCAVNYKCDASKNTIYNQKLKYIYLEDSLSYISMDILIYLQRFKGVIGLKLIKVDIKSTEFDLNSLLDPLQKEEDKIYLTNLEVKTYSKYAKDSNFLHFISVAYNLSKLNEISYHVYNITETDYFYFSKMNCLKDVFISIRDKTNIFIICKLFSNCNSIHNISDLNIEISKITKKNIQFLFKIKNLQMLRISCDEINYETIKCFKKKYFKNVYFKIENPNRKKRSDKMKHYLDLEFSTNVSRIPDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K3</accession>
    <name>A0A4Q9M1K3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0187p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="17077" checksum="B7C943CBFE33B7FB" modified="2019-07-31" version="1">MPHSLLDILTTTLLKTGNKEEIVSVINKKLQEISSVTNRWEDQNNMSEDEYDKIFCQILKLEEEYERVSVSDTSKWLKKENIRRHNKVVRHFPLPLLNRYKFKFSKRIKSHTVKILYNEYTEIRVDTRIKTKVNILDIRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K8</accession>
    <name>A0A4Q9M1K8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0046p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="128" mass="15124" checksum="3C15A100009DDCB3" modified="2019-07-31" version="1">MTDILWDTVTSVFGFNLNINIKTGIIVPILHMIIHLYVSLNYNNCNVIRNKCSFDIFLAHRAFIYFLVLIEGIFGKNFYISDNENFLYKFMSLVPVILIKFIYLIRKKSLIQSLMLCTHYSDIYFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R8</accession>
    <name>A0A4Q9M1R8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0236p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1R8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0030"/>
    <dbReference type="OrthoDB" id="2186978at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="52943" checksum="123B235592CE704E" modified="2019-07-31" version="1">MKLKIYKTFTQENNIIMSQDVLLHLEKHISDTNTLNLVLEKYLELYSTSKADIKKIENIFDLLKSKSEKSLERNYFLIKNNEFVKMNLKNKFNFLKQKIQAEIQPIYSLKENEETIIFGIYYISSTNKQILEDIDNTVELDFKYLNDSICLIENTFISVKGILINEIFQVNQVVLPQILKSKTGDLSLQKNEKKIIFISDFLINKNYLKRLENIILLNSKVNIIVLMGQFKVKNIYEEIKEFTNKFININFIIVPDKNDIFPSFLPKVLPYNLKYKNIYFTTNPTTIFLNDRTIYIIKEDIFRNNKNKSTFLDTNFKSESKSCDTNFKDKTDSLNTDFEDEFMSLETNNKENINLNHEQNIQNKSSFQGTNFNTNFITTYFSQYSFVPSYKEYMSFDNLPDLFIVGQKSFSHCQEIRNVLFASSGEFNKEGGTYILYDALQNKVEIKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V4</accession>
    <name>A0A4Q9M1V4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1769p0010</name>
        <name evidence="7" type="ORF">CWI38_0040p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001769">
        <property type="protein sequence ID" value="TBT98400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1769p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0040"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT98400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="322" mass="37765" checksum="77321CD71CAFFB11" modified="2019-07-31" version="1">MSVTESEQIIKPVIQEIENMAKTDVLLQNSLFNIKNLFNYNVGNGKNIRMLIFKDCFSMLTKSGFNHEILALCIEIMQSVFLITDDIADKSIMRRGKNAWYIENGLNAMRDACFMNSLISKLIKRQYGNTEMTCKIIKIFHNIFFKTALGQLHDTLPKKITNFDEAKKIYCFDNYIPVLDAKTAHYTFYLPTLLAYTLANLPEPANLKEFSTNAGMYIQFQDDYLNFFPNQAGKSGTDLDEKKLNWYLCLFMADIKSEQQKQDFMNYFIDNNTTKIMTYLEPYFKTYSSDEEKFKNKLISMMSDDTRCVYDYCLQKIYKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M225</accession>
    <name>A0A4Q9M225_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0112p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000112">
        <property type="protein sequence ID" value="TBU20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M225"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M225"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0112p0020"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="3">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="39894" checksum="F112B8134F4FDD8F" modified="2019-07-31" version="1">MVKNKNESIEKSKYEKYLHSLSKDQLIKIIFPPVNFIKNKYIKSYKKIALKFSYYGKNFHGLVMQDNKDTVELRILRVMYYNGLINSFISNDISFAGRTDAGVSAKNMVMSVTFPSILTEDENSNILKNTVERNNSNENFILEKNKEYDYIKMLNSGLPEEILIHSYSLVPKDFDARHSCISRKYKYFFRSNNLNINLMKEICKSFFEVKNFENFCKKSKEKEFKKKGLEIDKAYYCRSLTSISIEMVEDSVYCLNIKAKSFLHNMVRKIFWVLQQVGLNNSIDIFYKILNGDVQCGTAKAENLLFYGCEYDENLYFLGSNENKNDYIFEKFIKSEIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M235</accession>
    <name>A0A4Q9M235_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0212p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000212">
        <property type="protein sequence ID" value="TBU19444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M235"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0212p0020"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="1">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="37551" checksum="C949C3843ACFBE00" modified="2019-07-31" version="1">MTFQNLKEINNMLNPGYKTHNISVSIQHWQLRDMLKIHENNLIFAQGDKICGYNPDTKESSIFTENLGFYPTSLCCDHGYLAVGGQKSQLCVVELQSKKTFSTNLQGSINNAVQIYNHNGELRLMVCNNDHTIKVINLSNNENICNISHPFPVNNCQISNDGKLLASVGDTNDVYLYAIEDNNYRLIHNFKLINDGGFKVTWNTTSNLFSVATQDGYICVYDVRNLEKIHVIPTKQTPGLKGACRTVMFNRKRSLDILFYTEHMSSFGIIDTRTFSKRQTVLLSQADRDTQISGAVFSECNERIFVAVDDKILEYTINTPSRRVSSDYSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M256</accession>
    <name>A0A4Q9M256_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0106p0070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M256"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M256"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0070"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="24979" checksum="0D11DEF71485C7E7" modified="2019-07-31" version="1" fragment="single">MNLNNDDKLRLGTTARKIVENGKGILALDETSKSLEKRFALRNVTNTFENRVKFRDIILSTKNLGKYLGGVIMNEEMLNERSELQNKSFVEILQEQAISIGIKLDKGLIEFRDNENVSVGLEDLEKRVKNSKFKTAEFAKWRSVFKVDEVLPSFDCIEENCVVLARYARICQENKLVPIVEPEILWEGEYTLKRAQQVTNNVLSSLISHLNIQGVYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M293</accession>
    <name>A0A4Q9M293_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0020p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000020">
        <property type="protein sequence ID" value="TBU20819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M293"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M293"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0020p0050"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="22245" checksum="D1196697507AEBBB" modified="2019-07-31" version="1" fragment="single">MSIPSQGEILRSVSRTFIKKDTKSQNNKKLTPWRIITYITTFFIPNCILRLFNMSNPAVQQAWREKVTLCFLIFLGCMLLGFITYLMNILICKNNNQYIYSNLENAKLDREVVFINGVLSYIDNNSVDVIPRTNITPFIKQNISKSCRNNVINLKNAILKKDNFSEIGPIHYTYKDVNSLGYIIIDDKVYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2A3</accession>
    <name>A0A4Q9M2A3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0020p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000020">
        <property type="protein sequence ID" value="TBU20815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2A3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0020p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9351" checksum="413F49C52E1E03E9" modified="2019-07-31" version="1">MYLLRNKTPKIIKNIIPVTSRKSYILKIENLENIQVIQVYAPLSSLFLEKERLDNFCVLEIRRINPMRIELEENYISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2U7</accession>
    <name>A0A4Q9M2U7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0001p0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2U7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0200"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="26429" checksum="0BE0324A3CCCB6B9" modified="2019-07-31" version="1">MKYLRFSDFIFTFVYSFITGLFVIGFKLRFNIMYILYVQLICINYINAYLLRKNFGFFQYNIRKSFMYLIVHVSFVITFYINTFIEFPSLFFHSDVYSYIFRYIVSLTFPISSFLTAKIIRKKTRNDILYLIVLNLYFIISKVVHSMFFYKFAVFFPQVVFQSVQFFVMIVLCNLIFNPYDTLMFIFLYFIPYLLWQMNDLVNQYMFYLNNESINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M428</accession>
    <name>A0A4Q9M428_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0062p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000062">
        <property type="protein sequence ID" value="TBU20492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M428"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0062p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8886" checksum="86C29F49C193A60D" modified="2019-07-31" version="1">MRELYLCLPETLKVNFDIFTARLFGTYIIVNEISKIHSNWVSNVLKYSIHAKIISYFIVENKDFKADDKNPFSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4E1</accession>
    <name>A0A4Q9M4E1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0014p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4E1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="94314" checksum="4BD629FA56CB0AB5" modified="2019-07-31" version="1">MKDIPTRKRIFILALLFLIVLFLITCLLKVKIKDKNYCSNLENLSDLSLKKIALNNNSIIHISGTFLKDKCIIMGCDSSITMKDCKSNLKNNNCTYNIDGRKFKELIFKPNIFSLNNFSSAKIYDIKSKLKTCLDIEDDIFTKIGLYIFRRFCIYPNIKNIFKHAIKNESNFLTINIVSFGLKKEKSDILLFRIDLDSNDISELSKISKLCEIFQEKKIIYDLNSIVLFIAYYFDYINISYDINEKIRNIHSLFKKFCLQKNILIIHFQKVILKKFYFPYYFDVIFFLIENLKKNFHYSKNINSDLFEKLLFFKMYFYIKKFQEYFLAFEAGFSNKMKRHDYYSYKRLKNFIILTNEMFNKLYDFKENILKFVLIFEKVLKSVVNEDIKNIDVYYQYLPLKKVFIAKDRLLFYSIKTLIKRKSLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRAELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEAQLAKLYNEIEKQKLHSKLYNSRENKLVSVSDSSRWLNRGNIRPRNEAVFCYIQDRNVFWGADGMCQNCGKSGKTVDHLATRCEKMLGHVTPGGIMKPDIFILYKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHRSHLKRLEIPMNVEAYNQAIVLKKTVETISFDRKRGLDWREPQYKRGGDNDAKNLKAKNNTLLISEGKSTLEQATININEQSVFKEETSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4J8</accession>
    <name>A0A4Q9M4J8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0051p0010</name>
        <name evidence="1" type="ORF">CWI38_0063p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000063">
        <property type="protein sequence ID" value="TBU20486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4J8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0063p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="13623" checksum="F286BE149CAA540F" modified="2019-07-31" version="1">MKNDSDEDLYFSKKERNIYEMEIENKELRENLFENKEIGYTKGMNLQEKYKNIIYVLFGYLHSTYTCKTSVIECLADLIYENENLDFLENRVSYILKNRISDLKEIINLLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4L2</accession>
    <name>A0A4Q9M4L2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0059p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000059">
        <property type="protein sequence ID" value="TBU20511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4L2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0059p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="76553" checksum="86015947F7B6FD8D" modified="2019-07-31" version="1">MNEEDKFSVFKNNIICFQSISEQPKYYIPKIVTIPYNKNALLQSNVLKKNYECNRTDIRIILKDVSYQSLHIFLKSIEHSEIIVNKLRIQDFLDILIIISLLDIENNKKISDFIKELFINLIFSMKNETIPFDFEKYYDSPHFEKINKSMLMNLWILFMNIITFNDKATVRTTVRSELYTMSFKFIDVLFSSKVLPPKSLGTKLYLRLDKTSITHIYKIINVKYLMRTWIFLLKISNLDILYVIFLDQESYEKSVKLFSNITCKIEKIYVVFLKSSIKLFSNINFYIPCKSLKVFKLKYDYFTTDEIKKLLKICDPLQYITIKTKKLDYEKLNLLVDFFKKNPDKFCKIICSIYDILNTDSESLSHIPTNIIFYIDQIKTGSSYEKIPIKYMPFFHKQHYCYKLKDNDVFPNNIVFYECSKFIEITLDFTGSSVPFKLNSSIFTSMRYFKTIKYFFLENIIISDELLLYVLESNTILLLAVQKFCIASNLKFLSRNDKLINQSVNNIVLKDSLSNINCSVFDYLSRFRHCIGFKLVNVYVDYRVSCLKNLYNFFLSSSTIEYDKIYMEAFAFETEINDDRNTSFLQFFSLIYDFSKLYKILYRVYRISETEFRFFSEMRCLKNVHIEIRNRTDCIDFQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4P1</accession>
    <name>A0A4Q9M4P1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0030p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4P1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="661" mass="79261" checksum="E97BCD56EC8916DA" modified="2019-07-31" version="1">MVRNIYYITFLIKYVYSSRYDIYRKPRAYIDGEEDYWYENTQGYQSLQEPKQISLSILFRSPTRETHTTSHLRNESFDDQYMYANRHEYRPQQLFFPLYGEHTYKTSRTHFRFEEPFEYEESSRRKQRNRYLPYYREEKKHRNPGSNFEEMRFSAPRDNSFDYKLKDELNETYEPCKSRNLDERYCTERSDIYIENGFHNTEHKSKFCNPLYKNSNIKDEDYVESYNCTEFRDKNGLKIEKHDSCSTMELYVSKIKTSSKIIDTHGKNYAILENLVTEYIGFSDIQFFIEGDFSIDGYVLKADNALFFELIDHIAANENGFWSQIDSDAMIKYLAEKLKESVERYDFCKPCSPLLSYAKNIVNLKYFIKSIIKEDINLVKNSCLWIILLKTAESLCNVQPNKIVCDKNIIDEVLSKEHKDFDMYNGDKNAFLVLKRLYMVFDKIARKIFRMTKIPENYIYMLDFIFINVIYRNKDIHISQGGYIYLSRVISDCIFQIKPKIIIFFISQLKNLGISKPKKFDSVYLINNLLITLYKNPHKVDSKIRLNFRLMYENMIDSYIELFENEFCGLIILRDTESLVKNELKHIDLIVQKHKNKKIFLERLDLKDLIDVAQDICVMLNHFIKVGLNNEFYSQKYIQKSTKYCNKRLKAIFKILEIYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVF1</accession>
    <name>A0A4V2JVF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0221p0010</name>
        <name evidence="1" type="ORF">CWI37_0294p0010</name>
        <name evidence="3" type="ORF">CWI38_0318p0050</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000294">
        <property type="protein sequence ID" value="TBU03437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000221">
        <property type="protein sequence ID" value="TBU03852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000318">
        <property type="protein sequence ID" value="TBU14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0221p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0294p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0318p0050"/>
    <dbReference type="OrthoDB" id="2190236at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="497" mass="60049" checksum="7E5E26C2A364FCAE" modified="2019-07-31" version="1">MLHSEDEQEREFLFELESINKIGIEIEKDLKKIESYIKETPLSTLEAFKTYIEPKRNLDKIIYFYDLFLKSAENIYKQQEKIEIIKNKEIVKEEFDKEIKIIKCLEKIKGELFNFKKYQDIHAVKKFCDEVNKNVNVNLEMLEKSFFKYIGHQFPNMNYKTKICNLSNFLYLNREKSIFVKKYVDLFIIKYGSRKIENKYIELVNRVICLHEWIEEVKKVNDFLFEEDITGSINKEILEKLMLELKVVISHALMDIDRKNKPENLIYLIKLYSSIKIKENIRDTNMEMLFEFKKECLVLINNLLITFEQNIIHEKKNEKNFLCEQFNKTFLDFCDTFKENNNCLEELIFKFQENFAFENYDSFVNYYGVKCLRKTFDLSENLKGIQKCVYLLNNLDILQEYILEYKNIKIIEYLERNKNDIIKIWKNECEKRKHKESTEFLKLNLSIQRKYILPDLVRENVISQLSKIIFNLVSNSKYREPQDDLKNKINELFSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX83</accession>
    <name>A0A4V2JX83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1530p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001530">
        <property type="protein sequence ID" value="TBU10822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1530p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="519" mass="61367" checksum="9968FCF767DB4BE4" modified="2019-07-31" version="1">MNLFTIFLIQNSLCAGIKNKRSDTDLNTVNDESFHLRFTQDTSNPSVPPALDPFHINITNRHQDVIDDISLVIPYVKVILEAHLEITKCIFEDSIKEAIEEQLNDFKKCPSNPNFRNEKLIYNSILLNFMEIFLKKYIQCCKNQKTLEPNEIIDLTEIFKVSVLSKDFFVKKMLDIIKSKEITEKPLNTKEEKIEVIKSSIKDKAVQKLIFEKLFVLFAANLVFLNQKYTDFSVYIAIKNKEYLNSEIKNNEFFKIIKKIYTKNAWPLPKSYENQIMQTPEESKEELFMGLCGLICENYQNKNYSDKFMKKIFTLIFGDKQDRLTSVIQNVSNNIFPNDDWSSDELLRFKEILEKYLSHTLYISFSLYIEDWLIVFIRQIFSKFKKERFYKIVSEDFPDDGAKRKEILKEIFGEIPEISPFCDDIKPFLVKVKENLKSQTYISFYIYKVEDSIFNDIITEFFAEKKISKTKNFHGRNMSDLDMKIRNNVMCCFEYCFKSTLTSHFGNNEFIKKKTIIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA2</accession>
    <name>A0A4V2JXA2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1401p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001401">
        <property type="protein sequence ID" value="TBU11072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1401p0020"/>
    <dbReference type="OrthoDB" id="10672273at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="549" mass="65822" checksum="D8769204AD047B36" modified="2019-07-31" version="1">MIGKIFIGKLPTNVEKICGYGDEVVIKGKDKLYFYNLVGKIYKDVVCDMEIEKMVVVDEYLVVLSEDGRLYSMVLGGCELEMVANNVKVFKVFKKVYFIWRCGVYRLKITSEGIKKMRICNFEEGITDFCIFENKINLVVKKKVYFGYFDYRKKDSNIFGEASFLENLDVYKIEFCVTGWCVFENQTDLFILSPNCLYSVIKKPEKFYKFFLTKFHIFILSEKVQIYSLLDFKLVRELSLTAFGGNYDNIYECIWLYSNILYEFNINECNNNIYQSLIQNKLFRVAFKCFPIEFKNIFLNYSIYNFDRSIVKNGIKFYVLSGQKINFEQKNIITILRNKKDNTDFYNLKFVFNCKSINVSHRISLKKKNLNLNFILRKRYLIKSNTDLHLIAYYYKKTDFLKLLEFYFETKSFKKFCNLLIKKPKYCTRENLYKYISIVVLFKSKRITKIFSDMFNTHVLYYMTKHKDYRNLFFYLKNHFCFSSDTQLVCKIVITAEQSLKFKILKMFWTKKETNDNYFTFYNTLKFLVFKITNIRITDKSNHSIVLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY14</accession>
    <name>A0A4V2JY14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0293p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000293">
        <property type="protein sequence ID" value="TBU16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0293p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="36981" checksum="4C06083DD66B9626" modified="2019-07-31" version="1">MKKGSEVQKNMISLIFYILNFKMIEIWLSSIEQIPVLDFILSLSVGFCEAVILEITEINSSFIDFLNECSFFKNVKKILIFGGSVSNDFNLNSVHLPNLETLSLFMKNGIMESDKFIKQLKMVTEAEIKDSKFSTEETPIDNKEEKHLAESDKYLAFTISNPSNTTKFDIYLPCIYNHFAYNIFCLLLNNNFVDILRLEIKNLKIETLDSLKTFRNVKINLMCVSDSHINTSIYEKILQLNFLEILAFNNTIIIFEKNNLVIDSNTSISVFQFMSDKVLLPKNFLTLINVMKNLETLKIEVCDLQFLPIFTNITDVPKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY31</accession>
    <name>A0A4V2JY31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0263p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000263">
        <property type="protein sequence ID" value="TBU17922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0263p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="37171" checksum="9DD860ED8BA256C8" modified="2019-07-31" version="1">MRTPGNLSCSYQCEDERNLDLSTPKSNTIHASDKIHTDIDLARCLKTSNVVELDLVLKNIREYRLNEIYQDISIIFKYNVLFCDAYNTMAVNTFFAILDKLLEMEKSIMNPNHFKTIEYKQLFKEKIKGIDISTSRSAILSKVPVHNMLKKHVDIKKNIKGFTSKLFVSIFFALEYIESVIFGLPERINCIIMCLPDLKSDNINFNIHMNLNLMLYTGLAYIVQTNLKKILRYYFHFSEARGNRFIYGRYIFENKDTLYLLDAMFYFDDSDISDIYAFFESLEGKCIYELNLNKETEPIIENLSNKLIYKIIGYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC9</accession>
    <name>A0A4V2JYC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="20702" checksum="C94097831B9ED821" modified="2019-07-31" version="1">MSSCNGDTEKGQSDRFNEKENNDSLEFVFNNFLSYLFETYFVDIQNVIQCKRNKIIGLVDQKILSSEIEEILSRNANHKLTIFKKILSLNHKMDYVQSFSIKLNTENLFNDAKDIPIAFSKREMHFYEMILKVSRMAAKKMRFSLANLLKGILENGISTMQEDLYKIRRICQSCCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD4</accession>
    <name>A0A4V2JYD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0026p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9454" checksum="0A55783E0770477F" modified="2019-07-31" version="1">MEQPKMILKYPLIYINECMCYVCSMTVNKELDLNGVNIVCCMLKVVNIRCFILKGVNVMIDMDEGVNIKENMGEGKNMEEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE3</accession>
    <name>A0A4V2JYE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0018p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="26390" checksum="02203948996C126A" modified="2019-07-31" version="1">MSFKDRSTNIKNEIFEKKSKSNTLSDIEMIKKHKHINNKKCNEICSIGKESKFDIFGNKLSNDCDIDKLNENKKFEFQSNNIYKNKRNKVNLSEDTKKTTKNGKNRQNKKNFKRNAEIDNPDNSDSNLLSFETELENLCPFKCESDIRDKNNILLTLKEDTSNSKKIQSETIKSSEMIDEICLKSNFNKNNIGKCLDRAKCSKKRCSNCKKYIKFIDNLLETNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAP8</accession>
    <name>A0A4Q9LAP8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgin subfamily A member 7/ERF4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0090p0070</name>
        <name evidence="5" type="ORF">CWI38_0187p0040</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000090">
        <property type="protein sequence ID" value="TBU04774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0090p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="3">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="109" mass="12955" checksum="5C3664838A6C113D" modified="2019-07-31" version="1">MEVFYIPRDPRTRKIRFLTGIPDKIKRRISETDWNNIITEINEKLVTKISIISILSNLLIIPILFFNNRNLDKEIINYLESKNTVLRKRGIYICSPSITQYLELKVIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFA6</accession>
    <name>A0A4Q9LFA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2522p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002522">
        <property type="protein sequence ID" value="TBU06693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2522p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16329" checksum="9505159CD588DED9" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKTKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAISEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL72</accession>
    <name>A0A4Q9LL72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2339p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002339">
        <property type="protein sequence ID" value="TBU07870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2339p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="17340" checksum="285F403D8DC1B047" modified="2019-07-31" version="1">MFRSINKKDIFSSLKRINLEKEKIIEKYKSSVKDNTYEQLFEFEIEFPENKKVLNLTKKYALHNYIRKSDSKELEKLLYKNLHLDEFSLFLLIEKIIDSKRYILAIKLLHFTKNNHMSSVKYYELKRRIYKIYFQKEKNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP98</accession>
    <name>A0A4Q9LP98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2177p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002177">
        <property type="protein sequence ID" value="TBU09160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2177p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020935587" evidence="1">
        <location>
            <begin position="20"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="539" mass="64770" checksum="7661E0CC4EF67F69" modified="2019-07-31" version="1">MKHLFLPIVLPLFLLSSNTTVIRRKRVLEYRKIRQTPYIDNINEIKPLETYIKNNRFSKNTGVDDNKTPSILSLSKNNVLVWRNKKEGKYIGSSDMEKKYQIKKEKCLEFKHNKTETVDDFLSSNEEEIERIYDFNDDKTETVDDFLSSNEEEIERIYDFNDDKKHEYFLSKISEILEKKPNLKLARSICNSKAFLTDTTFENNNLKLIFFWLQKLLKELNKINKKNLLMNFEEIILGISAEEIVKYFLIHLKQHISLFVEMNIYNIEDFKSDISEMNLIVSKFLIRIFSINSRKKIFHLFPQFESVLNLMFKSKNSYNFLNFNSIFPTFLLIFIVEDSYKELQGGRKTNIEILYTNKYFERLLIFNYAIQELVCSLDNISDQVKPENLEMIPEFMDNINFFDENKSMLLHPRSNVHILFTYYNFLYSIVFLYIENASSENNDFETSLFNIIDHLNFIFYMYRNDCTLDYPTIFNMIEEMSRKFLKLNPFKNICSRTTELKILNRVFEENHKMSFFNRITRYNKSIRKNTSYLKRKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ56</accession>
    <name>A0A4Q9LQ56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1677p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001677">
        <property type="protein sequence ID" value="TBU10568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ56"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1677p0020"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="326"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="46300" checksum="FE653C22274C3757" modified="2019-07-31" version="1">MRIIIKNLPNKITELQIRSSFSKFGEITSFLLPLNEKEKPKRFCFIGYSKPNNVINIMNNSYINNSKISVEEIDNEKYKKYKNGEPDGINIGSDMTNSRVYVTNLPNTSLDIKDEIYKLFKLYGGITNIVNDSFAAIVTFDTHVSALKSLELNNCEFLGVLIKVRMYNNNIEKRFNTFFFDFKSIINQYKSKDKEVLLNLKDSDLGTNISLLESHLIAKTKDFLVANNIDSSCFTERFDKKVLIVKNYDVMGSISDSFDCRVSVSPFGSMALLYFKDEENARKAYKSLNCRRFGDKAVYCDYLPICIQKKKILEENLEVKQKNSVNKLIVKNVPFQADKNEIKRLFSSIVSVVDVRMPVKGDKTSRGFAFVTLKNANDVTKAIEYLGTNTHLYGRRLVIDKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH3</accession>
    <name>A0A4Q9LQH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1747p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001747">
        <property type="protein sequence ID" value="TBU10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1747p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10705" checksum="B1959A3E9ECB5AA1" modified="2019-07-31" version="1">MYQMCILITVNTHEYTAIYIVDGSKMELNNSCLKMTNEFHTKSLNRHESNTLIKLIKDSEGIVKQVKLTNFLFVLYRLGNLSEPKKTKDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ1</accession>
    <name>A0A4Q9LQJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1733p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001733">
        <property type="protein sequence ID" value="TBU10477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1733p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="396" mass="47113" checksum="6C1B1A9ED6EC03C0" modified="2019-07-31" version="1">MVILHLYKFVCRFLSEILAHFSTNNKIFEFFEDYDLKYLETTEGENSKSIFKRFMIKTRATSYESCFLDNVMCEFSRHIPYFKANKIFFDPKIDIKDEKNFPPGMFNLDSSNIFQISSAIIKEPSAPKEEKAEFSSAKIVSSNHTQISDLVQKITDKEMQPEKNDRNNCSRIYLFLDFKRYFETSFLFKFINLVCDEFEMKNDDYQRILIASRIYLSKNPEVHKNIKEQPEYFNILYKILEKLKEYQFSVCIVYYNKFYVNFSQACKNSNEPSIKKNETSSFQRAKSSLNQGIHTQNFDKAPVNSENKSEKRRLEPQNPEKLKKISEFQKEVLDKLIDEFNIKTYYFFYELFKPSTVDFSSEISAFTRLQIFGCKIEFIFLKNEISQTEEENLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK2</accession>
    <name>A0A4Q9LQK2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2100p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002100">
        <property type="protein sequence ID" value="TBU09871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2100p0010"/>
    <dbReference type="OrthoDB" id="108858at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25975" checksum="02FE98E8261D98DD" modified="2019-07-31" version="1" fragment="single">MENLEGNLLNLERRDSKYKQLTKEQPEFGMQHKLNTKKARYVPMFLQKRKKRCGRKPKEYSNKLAQIKNTPLNRQGTPRSLFFAIDIQKSTLFDIFKSGKYIKRISSTVKPTLTDKNKMDRLKFCLSKVNLANNGDLLFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEENPERNCKSKRFITKIMFMAAVARPRYDAHRKLYFDGKIGIWPFVYQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT3</accession>
    <name>A0A4Q9LQT3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1459p0050</name>
        <name evidence="2" type="ORF">CWI38_1479p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001479">
        <property type="protein sequence ID" value="TBU10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001459">
        <property type="protein sequence ID" value="TBU10957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1459p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1479p0020"/>
    <dbReference type="OrthoDB" id="2199595at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12708" checksum="95B1E41D0E7EE0E6" modified="2019-07-31" version="1">MKEENFENLREQIKGNNTLERLSSYGNLLENIVDYIVTSKINNNDINFLLESIKNQKKIYEFAEKLYEEIQSEEINRDKCEDDLNELKVACSEYKDFYEGHNTLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQU4</accession>
    <name>A0A4Q9LQU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1761p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001761">
        <property type="protein sequence ID" value="TBU10436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1761p0010"/>
    <dbReference type="OrthoDB" id="2233964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="599" mass="69213" checksum="85828068AAFF4DF3" modified="2019-07-31" version="1">MTNPCILAIHEGIMQMALRTIFDSITADPRNGLEFFLQTKKGLNEWLHRYYDEKFGCTVPLKVLKKLAQSEMGSEVKLEENGERHKFLSKTIESSEKDMSHSNASYIIQAAHACCGKITRKEKPRSAWKKNIKSKISKLGLSKDLLEKAQFYLNLSSVTDLSKALVKNNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLYERVESEYVSTMWNKNNDKVTYDDYSIPFVSNNHPTAFPSLDEFHYSRCGLAYLIPKGILQRGSDYRPITCMSNLYKLTTKCVTKVVHLEVERRGLLAENQLGTVRGVQGAKEQALLNIALNKESNPTLISFNNNIEPKKSFLQSINIQNLPRLQQLDSKAKLYFRAVLCFYLPRIELGRVLHSFEFKNEKKIIIRTKEYISVKYQNTHPALIKSFLKVKCGNLEIVQLAKLYNEIEEPKLCSKLRYESCSSIARIEIIYEKRKNVINCDKVGITSEIHSKYFNLKHLENKNLLNTALALSYRVKPKNMSNTHNVEAYIRSIIIKKLESVPNAEESWERASMGVITSAEMHEEPTPLLKQDSNDKVGDKKIKTKDFLFQTEEHNKGTAININE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQY0</accession>
    <name>A0A4Q9LQY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1546p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001546">
        <property type="protein sequence ID" value="TBU10794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1546p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="37477" checksum="4870CC641A03C049" modified="2019-07-31" version="1" fragment="single">MICFNYIRSMVLIDMIRSSNINSATTIRSTDEQLDEKQSPRQESSPISNECYTTPYNSQYYGYNIQNTLPQPEHLQPDKNTMYFYPVPQMCYYNAALLCNNPEFGIAGYILLDKTQPTNIIHVPAVQYDTRLGNEAYNYACFDHGTTSFDVSRDSYKPQKAKDIHLPKDKSDLCRKLLARNYKLHHIASRLEYEVVNAYDACICKTNQYAVFEILQRVCSKDEIYELEYFFPLLENDYDIFLKDIICHINDVFDLTENIKLSVNKLFHSRKLKGNISSELLERFKNNIMILFKTRGMPMIYLKPIFLILPIWIKNTLCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD4</accession>
    <name>A0A4Q9LRD4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1630p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001630">
        <property type="protein sequence ID" value="TBU10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1630p0010"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16696" checksum="EF59A263DC6FAD19" modified="2019-07-31" version="1" fragment="single">MVVKRKIEETSEPLKDTCFVFTGEMEMPREVAQQKVVMLGGRYTSLPSRRTTYLVAGNEPGPSKMAKAKELGILVLTEKQFLDFIESKSKNFEDREVVDLEYKNDDKEPIRVDSKDEDKHDKEYKDIHDKEFKDIHYREFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ0</accession>
    <name>A0A4Q9LRQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1837p0010</name>
        <name evidence="3" type="ORF">CWI38_1899p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001899">
        <property type="protein sequence ID" value="TBU10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001837">
        <property type="protein sequence ID" value="TBU10341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1837p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1899p0010"/>
    <dbReference type="OrthoDB" id="2200886at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14659" checksum="9F918FD0DC6E663B" modified="2019-07-31" version="1">MAFYTKTIQIPIQIHPADLKRPEISINNTLMDCHLKYSYKLQGVLVSFTLLSFSKTGEMPYGTPFVKLLCRIQCLVFQPEIGEILDFCDGFSYGIFKIMCDGNTNGKCIVEYVIKGNDDTILIKGKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT3</accession>
    <name>A0A4Q9LRT3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1804p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001804">
        <property type="protein sequence ID" value="TBU10381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1804p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="10807" checksum="6988D5CD6DD54EDA" modified="2019-07-31" version="1">MPNCRKLFSETKKIMFEYKNNYENSPLEHLNCVKEIKIKIIQLKKLLRKIERCKVKSTKVLNKLSEVIKEEEIVDLYKNYHIFDIDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS48</accession>
    <name>A0A4Q9LS48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1709p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001709">
        <property type="protein sequence ID" value="TBU10511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1709p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13183" checksum="42485BBA7515DBE9" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRRLESGLNAEESWERASMGVIMRAEMHEEPTPPLKDEKREEDGEKNFKPKNKAPFISQGETTLEEPTNNINEASDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS49</accession>
    <name>A0A4Q9LS49_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1254p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001254">
        <property type="protein sequence ID" value="TBU11349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS49"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1254p0010"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="606"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="717"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="847" mass="97013" checksum="EC017EA613AEF360" modified="2019-07-31" version="1">MTLTSIYINFPSYPLSLRKDLARQLQSSTVEDNIRALETIIILASQNQDFTDHLNLISRLMSVTQNKVLKSLFYKFLIMTPKTDSDGRILGEFLIITNQIRKDLTHPNEYLRSKVLQFIATLNSFELVENFIKPIQQNFLHQHFCVRRNAYFCITELYKKFGDTIPNVPQQLYDCLVTETDPNCLKQLYSSLLILDSDLLSSFMKKQDFFSLPPELLEIIIEKNKDLDFISKFLNHSEPTVSYCSALKIISQTNYCVKKDFNLILKCIDVLIPYLSDQDFKFTTLRIISNVNADLSSFVSKVMEFIDSTDIIFSAEILNFVFKYSTASNFSGVSDNLIKNFNHSKKSEFIIFLIENMTRMLKVSGTTSALFLEIACTSLKSENPGLSHAALSLLKVHLKNNFSPKILNFLVYALKDFKFGKIIRQCTDIILEFGEVEDYKKMIEILYSGINFYKNKKKQQTTADKNITSDTYSLITPNSTSRSPILFTLDNPAVPFLGPFFSLSIARMYIKIKNNLNENQKNEIKTKTLALLLEFMKMGEKENLMDLSGRYIITECIRTVINEYNVEKSIISDNKVVQKFNVLAPIKFNISKISSDDLIQPKTDISMSSDLLDYVFQLTGFSDPVYCEANIKISRLDISLDILVVNQTTTILQNCNFDFVTSTNITQNFISAPFNLPEMSVKNILCSFKIHESLNCSISGTFSFSYSGMNRECGSESILNLSEIKFNVSDFLLEKSISEDEFREKWTKLEWENTYCLKFRSNMDINEIVERIRNKIKGKIVSSVGHNKCMAYNIVCGTWKGTLILLNIGIYVENGVGFECRIRSCREDVVKSLSSVVGECLKDLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB7</accession>
    <name>A0A4Q9LSB7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1655p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001655">
        <property type="protein sequence ID" value="TBU10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1655p0020"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21439" checksum="D75FFD8827350928" modified="2019-07-31" version="1" fragment="single">VKSLSSNINNDLFLSSSNDCVNVWDLRCKNSIYKLSVNDSIVSFSSNNKFCVNVGDSLVKQYDMRNVTYGPEKTIYFDGHDEITGIQYSNDSKNIIISSNNIHTVVSAETGKVKYNHCFDKVSYACASPDSKYLFCTSGSHVFVYGIDDKKKVHTFKDSNFEHGLIKCNPAYTQFVTASTSVVFWMPPQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE1</accession>
    <name>A0A4Q9LSE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1421p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="PITK01001421">
        <property type="protein sequence ID" value="TBU11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1421p0020"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16564" checksum="5933A4FC04347B0A" modified="2019-07-31" version="1" fragment="single">TNNTNNTNNTNNTNNTNNTNNTNNTNNTNNTNNTNNTNKNYTESKTHFISEITFEDIFSCPEYSNTAYSQSLHFIHKHKTRSTYRPFQEHSPVLYRLREKSWDAINKGMLSMYDHEVLGAKVVTQHFIFSKYLKEDCYDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL8</accession>
    <name>A0A4Q9LSL8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0928p0020</name>
        <name evidence="3" type="ORF">CWI38_1287p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000928">
        <property type="protein sequence ID" value="TBU00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001287">
        <property type="protein sequence ID" value="TBU11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0928p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1287p0010"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="168" mass="20148" checksum="5EFBFEF35AABBFBF" modified="2019-07-31" version="1">MTNADILNELIIIYRNEKNIKTLLPYQTSIIETIYSLIQSQQTYLNALKKNQIIKNIIEQELDTAKYFLKEYLKIRIKKLQIYFLTSKDLLSSKEIIFQEKIVNLYKEKNIYVESEYKNTEYVGFICLKDIKQIFLDKNPVEIKNDDFFVAPLEEVYEYLYNNDIMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP3</accession>
    <name>A0A4Q9LSP3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1692p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001692">
        <property type="protein sequence ID" value="TBU10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1692p0030"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="4">
        <location>
            <begin position="464"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="878" mass="99342" checksum="BCB3D2F9E846DF7D" modified="2019-07-31" version="1" fragment="single">MEINSQNKRLKQTNKTLLQKALHYKIPINIYGTHPHTLISPHFFTIDLRQYTDLSTLIYTVHLTSTHLQYTEGLLTTACKYGYVTVITHTDTNPSIFDYLKPLFNGLLNISNEKFENEIQDGLYNENNRYNGNGLKENNGYNSNGLKESDNNTSCGNSTYNNTSCGNSTYNNTSCGNSTYNNTSCGNSTYNTTPLNNNNTINTPLTNNNTINTPLTNNNTINTPLTDNNTINTPLTNNNTINTPLTKNNTINTPLNNNNTINTLSSILSPFYNPHPNFRIIFTSSTKLQSNNTVHIGPVTYTLPLTPLISLLNTFYPFNKPPTLQDTYFITRLTNRLQSLSLYTAIQQTYIITLKTLKEQKEVEEKIKGFNIEDIDNNTPLVECTYNNTPLNNRTYDNTPYSSTFITNTPLNNNYINNTPLNNKYINNTPLSTNPINNTPSFAPTSQSLVTLSALSSCILYNEPVLLIGETGVGKTHLIQHLSNINNKYLYIYNMSSDTDVSDLLGFYTSVHPISVIEEYVGNIIKREINETPLCYLERIERYINDNRETEGVNDSSKEEGVNDNRETEGVNDSSSNYKGVNDSSETEGVNDSSTNYKGVNDSSTNYKGVSNGTNNYQPFNNSTNMYHPFNNSTNNYNPLNNSTNYNPLNNSTNYNPLIPYINIPLLLNSIKECKILINKGIPHFKYQQGVMYKAMTEGKWLLLDEVNLSPKETLLFIDSIVERIVKSNYEGSRNNTPLSNSGINNTYNYSIDNKYNTPLNNSTCNTTYILPLNNNTCNNTNNTPLNNNTCNNTYNTPSNRHTTLYNIHYNPLLYNIHPNFRLFCCMNPPGIGKKDYKGILFSKIFMLDFTDSITDINILTHYLLRERNSKITPLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV8</accession>
    <name>A0A4Q9LSV8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1626p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001626">
        <property type="protein sequence ID" value="TBU10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1626p0030"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16816" checksum="7AC504060996AA94" modified="2019-07-31" version="1">MVKISLKKIYATYSWKWDLEDEMCGICQQSFEQMCSECTHPVNCKPCIGSCKHAYHMHCVSKWLQSNKICPMCRKDWIVSEGEYIQKKEIAGILFLRNGIDTLTAYRVSLYILKKFEKIYKNINEESQLEEETTVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT02</accession>
    <name>A0A4Q9LT02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1597p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001597">
        <property type="protein sequence ID" value="TBU10705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1597p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020200504" evidence="1">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21667" checksum="D346F7F9E4887F81" modified="2019-07-31" version="1" fragment="single">MQLFLAITLLTISQSSNIPVRTIKKVVDYENVSKISNFNIPDIKNNKKNKVNNEANGYINASNVIVRKRTRIKWPIHKRERPVSYKHSTRQTFDSSFSIKKARIRTEKYSKIKDVRSYSVGKIDGPFSNKNERKFGFNDDKQHEYFLSKISEILEKNKIFELDSMMHCSEEFLTNGDLKNQNLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT90</accession>
    <name>A0A4Q9LT90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1245p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001245">
        <property type="protein sequence ID" value="TBU11366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT90"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1245p0010"/>
    <dbReference type="OrthoDB" id="2191713at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="442" mass="51704" checksum="66579095215DAC14" modified="2019-07-31" version="1">MRQRFWKSFTALELIGRGSYGKVYKMRNNSTGELFALKEVEISSKEYIEEVFREILPKEINHRNILKYTALFVSKRPSFLEQFHEESESDSRPSTAIDEEWLYDKSKLYDKDSIFFDSRFYSCSDSDSDSDVDISLSQMLNDSLRPGLFYTSSNKNSDIISISLSSSSQSSVVSSSKGYGFYGSFDPTKKIYFYILCDLCETSLRFIIDMRNEQYFRNDNVCKKIINLEGITSKNGNIAILDKKENDIQQSICSEHILLSDFVSRNYYEILSIPNVNRKNIFYVFKDIVRGLSYLHSNGIVHRDIKPANILFYNRNGNFIVKICDFGHMKLVDEVIEEYDSGYGCKESGMYTKASFSSDIYSAALVYFEMLWPMKTVMEKDITIRRMKEYEQVPEEFKSLFKEESYIIEKCLKYNSKQILTCRELMRLLLNYEKIFFGKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF2</accession>
    <name>A0A4Q9LTF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0993p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000993">
        <property type="protein sequence ID" value="TBU11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0993p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="17138" checksum="581CC3B59D92E432" modified="2019-07-31" version="1">MNTKEAADTAAKQECMKTGDSTCRSDNGGNPLALDQSGGANAAERPTVTNETGQKTAPDNSTQSGSFNPLEAAFTLFNDTPAGKGLGFASGMANALFNKPTQDGNLTQNSTVQNQNPDQSVKIIPYALTWDGIRASLSVIEIPKQTINIKEESDLEEDNEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG7</accession>
    <name>A0A4Q9LTG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1202p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001202">
        <property type="protein sequence ID" value="TBU11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1202p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="275" mass="31524" checksum="6370DC83B09C1A7F" modified="2019-07-31" version="1">MQEDRIAAKNILQNKKYIPHTKRISYLSTLLPTHTTQPKKISFTYNTSLSLLQNINLNNTPSSNNLELKKFHYCDSYEFLLSLIKRNSFTQKYQKYFSKKAIITRNTTCKVINCLKLKAPITILPNIEIINKDTEIFSKYETTYTTSLPTENYTTPNLSLTDTYISSASPTSNISLNSSFSSINLHMSNFTVHKRVISHSYWCDKIHTTSSTTPIFSFLTPFKSSNKIFFLSTCLTFIEIEITGKRTVTAIVSLNKFITLIQGKEEEWLKTIGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN6</accession>
    <name>A0A4Q9LTN6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0947p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000947">
        <property type="protein sequence ID" value="TBU11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0947p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50952" checksum="0283FF4AAB82FE2C" modified="2019-07-31" version="1">MLLVQEDGSVYNDVTWAYNRAIHSASNKSAFQPFNDQLVFIIFFFVVFDNGYKRLFSIWELEIDPVIYNEVNKPYYLASYPKTTASEIYKNLETDTEIQKTIRNLLFGDKVLLKGDFDVNTKTKRTPSDSFYDDSVFTVTNIFIGNMIDVSDSSRWLKRGNIRPQNEAVFCYIQDRNEFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLDLLLLNRYKFKSKKRIRSHSVQEILNNEYAEIRVDTRIKTDVKIRNNRPDIFILDKRKNKITLIEVGITSQDSLQIVETEKLRKYDLLANDLGLIYKCSVEIIPYVMTLDGILTKYHKSHLKRLEIPTNVEAYIQSIVLKKTVEIIFFDRRRRLDWERASMCVIMRSEMMQKIKHPLFYKEEPTNNINEESELEEETKVVKEVEETYKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ6</accession>
    <name>A0A4Q9LTQ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0947p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000947">
        <property type="protein sequence ID" value="TBU11989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0947p0020"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU11989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="455" mass="52773" checksum="FABBDFD7D604054E" modified="2019-07-31" version="1" fragment="single">MENKRLNYISSLEQHVDTYVEPNNAEKYFVTFPYPYMNGKLHLGHLFTLSKAEFMARYQQLKGKNVLFPFAFHCTGMPISASADRLKEELKESEIFKDSKNIKVSEKLEEIKKESGSSVSKILTDMGISFSELKNFCDPIYWTKVFPILATKTLKSFHTLIDWRRSFITTNINPYYDSFVKFQFRKLKEANLISFGKRYSIFCPLTNQACLDHDRMKGEGILPVAIDLIKITILSEGDFFGKKLYGRIVFNNRPSKIIINSNDYFVVSKDFIFCKNIYENLKYQGFKESVVEIKGSLLMGLKCKILENEFVITEGKVNGCIVKGSSEQRKISLENESKNANGKIDCCIIKECEDRLFLLENERKEISEISDNKTEISLNFTENLLRFYEPESEVISRSNVRCVVSLLDQYFIDYGNMDLKNKTKKCIEKMIFTKETKEMLIGGLDWINKWGCSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR2</accession>
    <name>A0A4Q9LTR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1361p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001361">
        <property type="protein sequence ID" value="TBU11141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1361p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020519048" evidence="1">
        <location>
            <begin position="20"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="755" mass="89478" checksum="07CD3D5468B019BB" modified="2019-07-31" version="1">MLFLCLLALKIILTQNTIAIHFYEDEGDNLVWKDIDSCIYTEKFRNFSLEKCNSTNINSNIKILRTFIIDLDCFILKFLNDEEIRQGRQNNIFVDNRLIDSEDFAYFNKTVNSIPFFSDNIDESKYYMMFKIMNVFRFIYNKHLVDFIRNILVSMILNTNTIRKNKHLFKKTVAISCPDYVPKIVIVELFKLYKIGVKTLEKIKDISCAVKITKEFRYDFLNLNEEYLFLDADVIQEVIKTNIKANCFFQMLDIMFNIQIFKRLFMYNISYTEKFKYFFNLSLFQNLDEIFLLECTNTDSLIRTLCKTCDSISVKTLSIVYCKFTVNDEISWLKKFNFQNINFVFEIDLSDSYFSISKLKASISYVFLELIDEVNNKENKLNFFVGDSKISCFDQENSYILHFYQPKSKLKYFKIPEATFKIFLYMELLNSFITFTFNMMNFDKLKNIMIEFKNTNLENFSLQETEIYNNIVRMHIVESTINNVFLSKILLLKSLINILFYACKIVFPNEKVAFKENTNIVNFHFACSFFEDHNSGIEFLNKMSAMKILKVVSYNGHTNPFAIEPSNEILRLDNLDSLDYSVSYVLNEQSPSFSFIPRLLYLNFGFNYPENSLYKIFGNKNLNFLKTLRFDTVIIGKKDRQMLVEYTNLLHLRFSEGSKISGILFSELFDLTRTYSFTELILPKIEITYCELQFFSSLKSLIKLYIHEFTLEKDILYFFKTFNLVKKIEIGNTKIFKNETREEIGGRLKNRADNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU37</accession>
    <name>A0A4Q9LU37_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mismatch repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1397p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001397">
        <property type="protein sequence ID" value="TBU11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU37"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1397p0020"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="311"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="732"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="912" mass="106473" checksum="8DC5F59622B019B0" modified="2019-07-31" version="1">MIQQLSTFSSETIQSQQTFTNIFSITKELIENSLDAESTVIKVFIDNLSIKIEDNGIGINTIEKIGIEGFTTKSEQTHYVLGDKPKPKFSFGFRGQAIFLLRKICDIEIISRESSVPYALKYNLSKNTEISKTFKEPGTTIIVTNIFKNCPIRRKIFYSQISKDTEKLISLFKSYCIVYKTEIKLFLKNKLIFDESGFGNIKKYFEINFPEHFNTKNKNEHGNKNENLNKNQDGNIKDGNINEDVNINEGKNNINESKNNINEGKNYINEGKNYINEGKNHINEGKNCINEGKNCINEDGNTKNTKNNFEDEREQNEQTSEFNSYIEFENENFYFLISKISSVSLKSFIFVDLRPVKSKKITKQICQIFNNFSSNFPIFFLKIKEDSDVNVSADKTDFVLANENNIFNVLRDVMERNLCLYKYVSPMNCNYEIEKQEHKDYKEINNELRNDYSKDLIRDSSKYLQTHCCAHKNNDKESNTKTFFYENLEKFISNDSLENEILTKIDENKDKNYKISEKNIFSRILNCKKPKFNDKNSENFEDKKSERSNVLNEKSLNTANNKIRNKKYIRGDNISSSSFTNEYKNEENYNESTEENIFISPTDINLEENNDCIPINHKQAENNCIPPVNQKHEENNCIPPVNQKQGADNRNLVSANHKHDENNNYIPPVNHKQDKDNYKNIISQDIEEQIETPNPFYIEKTKNIFLHFDDPIVSSLNTKIILTKKDFLEMKIIGQFNCGFILTELIKENKKYLIIIDQHAADEIKNFEFLKNNFYLKKQRLIVPLNLKLDSLEEYIIKSNKSVINRNGFEINNNLQIICVPIYKNQIFGKNDFYEILSKLKNTNQSEKYIFCDRIKDIMASKACRQSIMIGDVLSYKQMEEIVRNLTDLNIPWNCPHGRPTTRVLCVLEHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU64</accession>
    <name>A0A4Q9LU64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1005p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001005">
        <property type="protein sequence ID" value="TBU11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1005p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020201242" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15189" checksum="4E57F31B824727C9" modified="2019-07-31" version="1">MQFLFSILSILLIKSNISCSTSIVDLKNINATKNSKKDIPDAKSVNDVCYIFELTKVVETIPEVLPEVSASTSAIKTPKSDSRPRKRKRLAVEKNQQEPGFGIYNDETQKQTYMIASYELKIDKIFENIKAASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC2</accession>
    <name>A0A4Q9LUC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0831p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000831">
        <property type="protein sequence ID" value="TBU12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0831p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="374" mass="44845" checksum="D18BF9374FDB9309" modified="2019-07-31" version="1" fragment="single">SLCRKDEIRRLENFYPLLDHDYTISFQNILDCRKKINNITETIKTLVEKILANRKYEIGFMCYLMKIFRLKAPFIFHARNRPMIYCKPLFLLFPLWIEDTIQKELTLAKHLFNISLILNVTKAIMKYNYECLKPFFDKKLRESMQVGFSYHFCCNKCLMYNHFNLIIEFLGDIFTMLGEETYQKVLKYVSGAGFLSTNCDNVFTKNTSLEIPVILFDVFILLSKENFEFLHSIICDYEVLKESLENKDLKFISYIKKTLNEESYLQNENCRKLYYNLVSIYERVFLGESSCDFIQNPFSINFKVWFRENMSRYRFVICKKLIPKYFDILFFLKTSNLFLHYVCKVILNPSITPRKFEDILVQKIIRCLSAKHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH4</accession>
    <name>A0A4Q9LUH4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0998p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000998">
        <property type="protein sequence ID" value="TBU11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0998p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="16147" checksum="97B5A7614CE3D54C" modified="2019-07-31" version="1">MIINSWPKPPIRKDESPPIIPKEYTCFGVNFIINQDGVPRITENKNIKEIPFKEIKNSIERSLLLFNKVLSKIIKDKDPSKYIKMIRDVHLNINQMISDSRYFEAKESINMLMKEKRTKCKEMEQKINEMLENFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH8</accession>
    <name>A0A4Q9LUH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1294p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001294">
        <property type="protein sequence ID" value="TBU11265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1294p0030"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="410" mass="49008" checksum="E68A1D42FF3AD5D9" modified="2019-07-31" version="1">MEELYSYIYVPRYLETRIFIEMKNETKKFIRKFNNILYTILCLFYKRKCISNVQIIQSFTVLFGFLLFRILNPAEIYHYIRLQGVMKLYVLFNVLEVADKLVGVILNDVTKVLLSISYFNISSTKTCTCMKDSKYRKDCENFFKNNIDIPPMKDNDYNNNTCYKRDCEDFFKNNIDIPPMKDSDYNKDCCYKESEMCVYDKEIYCEKPLKYQNMKEWNLKYLCICSVYFIANIIQTGILYIQYITLHVSINGSRNNLYSLLISNHFVELKSNIFKKIDTKSLFNILSSDISKRFNIFIYLIIILFSNIDDSEVNESVVSSFNRMIYPMCVVFGSKIFIDCLRHCYICRYNNIFYNVYLNYKKDESVKCEQIALNILFLTVLSQVWCFKYLDFKFLVTFFSLSVGIEWFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY9</accession>
    <name>A0A4Q9LUY9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_0865p0010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="PITK01000865">
        <property type="protein sequence ID" value="TBU12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0865p0010"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="770"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="974" mass="110770" checksum="7429388B658FB23F" modified="2019-07-31" version="1">MYDTYNLEGKFFKLSAEDLENIVEKKTIFIPNLINNIEDLGSLLYRNLKNGSLELDKEHLLIYESSLVSKNDLDLSNIEKIYQNYNLYRYGNNENTIENKRSFWSILINNMNDKTLFLLLFASIMSFVVGAYKIINFSEKYSWIEGTSILVAVIVIVLIGTLNEYSQENLFGKMDKKNTDYNVKVFCNNAFDTKKSSKLMTGEIIYLEPGDIIPADCILVSNDKITCDESMISGESETVEKKIKNDIFLTSGTYVTEGSAKALILAVGTHSVKGKIMKNMIKPSKKTPLEVKIEDLSQNLARKAIYVSLLLFLSHTIKGIIFRTSYDLNRIMEILIESISIIVMAVPEGLPMAITIALSFGTKRMLKDNNLVRDVSACETMNNTNYICTDKTGTLTKNEMAVKYIYTDNIKIEITNIYGHQNVSVLRRIEKHTSLNHTIKNIVLNCSAFENKEGKYIGSKSESALLDILKKDDIDYKFIRKRHKIIARHTFSSDTKYMSTMIKYKGKYVVYFKGAPEVILENCKFEMKNDVLKPFYIVSLMDFLEEADRMCYRTMVMSYIELDTFDPQAIIIGKYKTTFLIAIALEDPLRPEVSEKIIQCKEAGINLVMLTGDNLFMAEYLAKKLKILTPSYYCISGEELRSKSDDELERIIHKIKVVARANPLDKKRFVNILQKKGNIVAVTGDGSNDGPALKSADVGFGMGISGTDIAKEASSIILLDDDFSSLIKTVAWGRCINNSVRKFIQFQLTVTITTIGVAIVSSLLSSTTASAFSPIKLIWINILMDTLAALALSTDEPDDYLLRRSPEPKNAPIITRSMKLFIIMSSIYQFLLISLLYYLNLGNTFIFNTFIFVQLFNEINARSLDPFHSPFIGILKNKIFIFTNLILAMLQIIVVQYAGIVFKTIPLTLNEMFATIFLGFTVIPYFIFIRAFLRLKFQRTARDWKSSFRHLSMELRLLEAFSNIGDENCEVFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV17</accession>
    <name>A0A4Q9LV17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0311p0030</name>
        <name evidence="1" type="ORF">CWI38_0728p0030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000728">
        <property type="protein sequence ID" value="TBU12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000311">
        <property type="protein sequence ID" value="TBU15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0311p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0728p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="10143" checksum="B38F660D09A33346" modified="2019-07-31" version="1">MEEGDFEVTFNMSTKNAKLIQEVLDLNPGFDTMIDSQYEVMDDSLFEQFRRAIDCFLLRFKISNDTLVLEHDGPSDTVSSKNDKKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD1</accession>
    <name>A0A4Q9LVD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1140p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001140">
        <property type="protein sequence ID" value="TBU11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1140p0020"/>
    <dbReference type="OrthoDB" id="2191898at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22475" checksum="3AC3A1AE2E6465C3" modified="2019-07-31" version="1" fragment="single">LLITNIEDDIIFKKEFDIMNDKEYCSLFMLGYSSLDIIEEIRFSTVKTFFKSLDTQSKWDVSVYFLPSGFKLIYINEDSEEKRVYDFMSKVHILLRKKMLEIDVQKPEVFNCEILLSADISVSINQYGNGNNTASPFYRLAKFTDVKRQDNLCLSHFEISFIGLSERLLNYNKNKNLDTMEYDDNLPLSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH6</accession>
    <name>A0A4Q9LVH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0662p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000662">
        <property type="protein sequence ID" value="TBU12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0662p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="416" mass="49875" checksum="A796002A93DDA352" modified="2019-07-31" version="1" fragment="single">MKYLKDSMKWLYSKVTDFVLQETTEEDNYDFTSYINRSNDVNKINTTSESPSAQEILNDLFNQGYYCRDEFLERKRKEELKNESKESSSHNFNTKVTKRKRKEELKNESKESSSHNFNRKVTKRKRKEEKIRKKVKIDIDDEYVCRILEFKEKYKKSQKKAFLEANIPYIKRKVEPLSKKKIEGSFVQKKIQKLKRLASIENRNLTNEEIAFVLENSSLLVDDSVSPTQALKIGKIVNYIKNYENKYKPSFTERYRIKIDEPLDRRGIFLDYYQEILEREKKEEKIEEENKKVIFRDQIQFFDELQENDRDSQFNIQLGTNQTDEEIYGIPTYKNTSITHNSINFLEKPSQPFSKYSFFPENISEEKSKIQTQNFTSTEPTEQYNDQTISKNIKEIQNFIKNEGQNEIPYYTKMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ1</accession>
    <name>A0A4Q9LVJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0772p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000772">
        <property type="protein sequence ID" value="TBU12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0772p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="703" mass="84442" checksum="FC18EFFFCDC3F960" modified="2019-07-31" version="1">MEINNNTKCDTLLYQKDLYFLCTKTCSLVSNFEGREFHYDDSCDSHNSMTTFNFIYPNQISLGFDLLDEKILLNKEEIFIGIEKNCFMLFSYFIKFLEAEDNIFSIEPNLTFEILKYLNIFRIKRNHLYMNFIKSLTFHSVMFKEEAFSEKTAEIFLDYSEYNNLFILDMIEYFCKFYFLPKYFIDKTFHKYSPNRLFFRRKLHKKRSIFRNMQIEGIELEIYNYFLNSRFRSIWQILIKIFYLDKLYLDLYTRFNDTNMDIIVSSLPPKPKKITLLVEESHLPIFDKLNKINYFKSKKTVKLIVACDTKYILERIEAFKNQEKLILIFNKIEMKELVCLESSPTFESIKYVKIRFIILTEILSKVASASFQGNRKNIYIDFSENFKISDSENNLYELPTYNFKDYIIGISLKLCKQNYELIDFKKLFHPEYITRLNLDLKNVENNSLSNYFFLESFKALSTLYLSNIKLTGELLKFILRSKELIFVWFKYFVFDENLTCENLDFINKSVIHMEFYDITHHLNIQYYYFITRFIALRYLLVYNMIDASISRLKKPVLLPNLCCFKYTNEVMYQNSSKFSSLHIFSFFVCFNFLEKLVYDADALHLADIDIIENIKTLKCLKLCVFKIDIEFNILEKILRSNIRKTVSKLQLYVNEFTSSELFSILSFKNLKFLRISAMNFEERNKKYIDLLTGMNLINFVAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ7</accession>
    <name>A0A4Q9LVJ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0653p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000653">
        <property type="protein sequence ID" value="TBU12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0653p0010"/>
    <dbReference type="OrthoDB" id="630633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="109014" checksum="6CC8CA3DDA67D4EF" modified="2019-07-31" version="1">MGEEDTYRYMKSSKCMKSNKYERIGGSNCRSVGNIYIMVILFTICGVFSVNVDFIISKNVAYNKYDLDCILCDYMEYLDDEGQYKLCSGYHIGNKECKNEDNEEYKEDGEKNNSKDICSTMNETKDIIYNTPILGNDTIPPVINPNINTNNIKTADFCSAGNDMKKHRSTVTVRIDYDDIKYIKLLYVERIKDMSGSNTIPVYLGDNISYLNLIKFIEMIKYNWLGIKEGIDYLSFYEILKTIKYLKVEEGRGLMALVGGLIRNILGRCVCEEIIADEYRLEKFVWENDFCYYLCLLKGYLYLNECNLEVGNGVVRVFGDLCDERLFFNDEQIGYCNEMCLELYFEDFFYFLRYKSEDEIGFFLWLFGKIGFKKVFFNMGSVGYTGKTWSKKKNETIHFKFESVFNEEFLFKKCSLPLSSNVLGSNNNYLSQTFDRRSGVTEPLHVIIPDNEIYFDDNSLNKRPGITEPLHVIIPDNEIYFNNDFSQESDFIDREIRYDNFIRIWKQNDIKLETIENIYLFNNFNSEDVPLFLENLQIFFPNFNKLKITDFDFDEEIINIIFRFKIEYLSLSRVSLENLKRKFDFDTNISKTIKKFTFKNSYELPKNILEYFLSSETLQQIKICQIEMMVEIPLRNIIFKEFDTLEKIIITDTSIDESLFTLLLKTKSLKHLNISKSKLQIEIANILILESIQKNLKVLNLNNIKLSQKSLKKIQLFEKLESLHLSNSLTCEKPIFINFKSFQNILHLDLSSNRNISLSLSQLKTFKNLTSLNLSYCDLPVGFMSFTKDISFTKTLKELYILGNKIDFTDLMNINAFEVLQNLSISFIKESNIYFKDIFKIKSNFTLKRLAIETENISLQDILSFEVFKSLEHLKFFNSNFLSDSFQYENKNLKYLKVLHFESVTANKKDIEILKNIFGNIFIITTCTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL8</accession>
    <name>A0A4Q9LVL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative diphthamide synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0684p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000684">
        <property type="protein sequence ID" value="TBU12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0684p0040"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="40044" checksum="987157570160C3F5" modified="2019-07-31" version="1">MESYRLNELVKNKTNVIIVHTKEYSYLIPDIQSEIENLNQNCNVFIILQKDLICSQKITAQYDSIIIIGSLCPLHSDFKNSYIFKFELPIQNTSILFNGRRKLFIDKIFRTENTFSNEIQCTNNINLDKKNLENDDILIVSHNQKIFDYFFYEHSSCDPYFTEKITKKDKCRFLISRWSRIEKIKEKNVFGIFFASKEYTDLANEVKRFLLKKEKRVFLFFLKDISSERLTAIDGLECAVIIDCPLFINFDIQCLIPVVTPYEITLAYEEHWDGRYFINRFEVSEELCELEIVKYFDPVNVIVRSDFKGLEYDGEEVNEIEEGRKGIPREYNLDYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW00</accession>
    <name>A0A4Q9LW00_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0590p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000590">
        <property type="protein sequence ID" value="TBU12903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0590p0020"/>
    <dbReference type="OrthoDB" id="2193650at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19035" checksum="F49CE3A953F7A320" modified="2019-07-31" version="1">MKTIAYIFSKCDSNLPQIKWSIKEYIQPQIHQICLLYCLPERWYAINDPRTLLMCTNICKSDYSIRKKKISNYLNDIEKIIIKEFNSDIKVKKLIICGDEKYKLRAVLSSLNVEIVILGPDTLTDGLSKYFKKSLDEFVTNDINIPVLRVPDFRKSKKGGFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW25</accession>
    <name>A0A4Q9LW25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1022p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001022">
        <property type="protein sequence ID" value="TBU11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1022p0010"/>
    <dbReference type="OrthoDB" id="2195422at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="22269" checksum="40752FE820237998" modified="2019-07-31" version="1" fragment="single">MDNKERTEDFITNKSLQTTGNDTIASIKLSYASPDIRTFTDLNLKRSFDKIIEFLQILPKKPNTDCFLCQQLSNQSTEYTVYELIKDYSKAIFCISQHTEKTKDTPQLPKSLILHSIFLEFSVLNEIAEFPLSVQEILNESLNTTFNTSMRDQLVATSKSFVLDTSINIYCEQDIESLTYKIYKKAHIYSETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW87</accession>
    <name>A0A4Q9LW87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0689p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000689">
        <property type="protein sequence ID" value="TBU12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0689p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="645" mass="76654" checksum="5FABDB1E6600DCAC" modified="2019-07-31" version="1" fragment="single">MATQTFDYYDKDFCDSIPEQCENLSTQNHEMESESGSCIDIDELVDREIELQTADNVVSDFRCNNHSVEFNPLESAETTNSIQLTDKNETDTDLSLSFPTLNRESLNETTKLTDEEIHLPIQKPHESRLKLKRILQQKKYKKISQRRTTGQTISDFDQKRAIKYIKDLHSEVKKDISKIEDENNLLDMSEIRYEYSFRIVFKRKIQALEMKRFKRNEDLACELKFAKSIICHEKKFMKNLPLEEKNLLLSIKFKLKNFEENILDLKKYHILSEIPFLMYSYNKGSISLKEDCVFYVSYMFKILEVCYLNSKSFIGLENQFFFEYNHYIISLRLIFFNILSGIKNFECNKNFYIVISSLIYFYDIGGIRKLPLKRIIYYIQLNILLNRVFLNNFDKKEVEKAIEFYESELSNESGSQTSYTEICFKKFFKGLQDIDLLRKYTEICMSSIIQANLSNTVIDTILFKKLDAIFTKYANKKTYTDTKLEYLKDLFVCETIMTRIHSRIIYEDIKLKKSFYNSSISNFIEKLDDTLRQITSDKCKYSSRRLKKGTFCYIQDRNVFRDAESMCQHFNQSRKTFKSLKQIRSHSIQEVLNNEIKIYVKIRFEKEKLRKYDLLANGLSLIYNSSVEIVPYVMTWNSIVTEYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW92</accession>
    <name>A0A4Q9LW92_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0564p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000564">
        <property type="protein sequence ID" value="TBU12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0564p0040"/>
    <dbReference type="OrthoDB" id="10027416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020981342" description="Leucine rich repeat protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="89557" checksum="9B30E20C56C8D63C" modified="2019-07-31" version="1">MIYNIFLLLMTVLTTEIQMFNLIKTKISDIKVKNTDKNNWISIFTYKNISYHYRNADNHIFRYPKDFFVRLYGFERLENIFIKEYNTNQVLYVLNRLKDFDYMNRMINTKEFLVYIDILLLFEVELGRNIKGLIFSQITNLKFINYDFASNYKKFNYNSNVQNLFLIILKQFLKYNLLTKQDIHEFFGKSDIKKNAKKIFEIKKKFRDEIRFVLTDSILQKIYKIANGDTRKQEFIKYIFSNIKIKRLTIMNTQSLNNLLQINRSARLFLYSTINELKFDSVRISSTFLLIFSRMNIFREIETLIFYNTTINSLHFYELNHFKNIKKLVFNNSLKGDYIYEYFQMLNESLPELKVLKIFEFNMKRMFNRNIIYFEKLENLKLKFMTELTDSLVFDKAFIHSFARKLTYFEGRFDFLRLSEIFFSLNDFPLLKTVILHGNQYTYLKKNLNPDISNLRFQKNLKILKISISVIKEYELYSIMNFNNLKTLKFNYCVFDISSEFFLNQNASLSKVKKIRFRYTKFPLNIFTYIIRSESLNCIDLSYSLDILNISICLINFRNKQNIIKINLSGKYLEDLTRNIFKGFSDLKDLNLSNTTRYGGDLIHILNTDICRSLEVFKYDKNTINAEDIRSIEHIKNLKYLSMLRCHFIDNCGFIPACIPIYRTLKHIDCSYSKLPYNFIKSLALFKKLRIFKLLYIEINHRKLKVLQNTSPNCKILTNEQNLSNAKAFNYIKEQFSEENILCANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF8</accession>
    <name>A0A4Q9LWF8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0537p0020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000537">
        <property type="protein sequence ID" value="TBU13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0537p0020"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="476"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="731"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="853"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="892"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="928" mass="107978" checksum="994FE800928D682F" modified="2019-07-31" version="1">MSEIQLNIQRFKKNIQRLREYIPPSSTLFVILGKPEDEQPFDTNSAVFLFLFGYEFPETILLINDSNMTIITSPRKACILEQLYPHTSLTLLVRRKDNSNLNEIKEKISTFTCINVVEKEGLKGSFEQNFDISSYVDIKPQLLHVFKIKEDYQLESIQIASHLASYFVDQAKTFIINSFTNSLKKTHLEISNFLEEIMDKPININLPENLHFEQDKLEFAFTPFIQSGEAINISSFTENPFESSYLELPFVIIKIGVRYDGYCSEISRTFLINPNQERIDYLDSLYKLRDFISSKILPGSDSSVLKKNISEFINSCDISLDGSVFYSIGLLINEGFCINLFDEINEDFKIEKNMTFVININSKNMILSDTIQILEDKIIFLTSKKTKENFILNILLKEGRLKVNEKLGFRVRSKEKEVEKNIQRKEHQKDLMNDLIEEMLEKYKKIKKDNIGDSEIKEEIFIPYKKENLIPRERKLKVDFKHDSILIPVYGYLIPFHISLVKNISKNEDGSFSFLRINFSTESNLQKTEFLKSLTYKGNTHHIGDLFREINELKKDFLIRKEEKKNFKDVIEQDTLVEIKGKKNVLSDVLVKTDFKMGSKKMKPSNLEIHQNGFKYTGDISLEILFSNVKHCFYQEGTLENRTILHFNLNSPVIVNYLNSSKKTKNFQFFKEVGVNSAHDTFKLKNDEFMEMMLDKEEQEKRKLVNDEFKKFCNKLEEYGLVVQILLKNGFYGVPYKESVLLSPTMECLVNLTEFPFFILTLKEVEVVNFERMIFGVKTFDMVFVMKDKINLQTVSIFSVDSSESLNLKDWLDSNNIVFIETSVNLQWNNLLKSILKDPLSFYENGGWVELMENRSESEEESEEESSTVSSVSTVDEEVLSDVSVISSESEVVGEEESDFDSGEEYGASEEDDWEDSEEEEKPKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI3</accession>
    <name>A0A4Q9LWI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0943p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000943">
        <property type="protein sequence ID" value="TBU12000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0943p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="19604" checksum="D32041170AB18CD2" modified="2019-07-31" version="1">MRYYSAIPRIECILQRRWYFSTFHNVWLKLDCLATRFEKKVNNYTRRHNEVYAEIRVETRIKTNNYNVEMIPYMKTRDGIVKKYHKMYLIRCKTLINLEAHIQFIKSPLIDEENLVSLGFIEEDEMHEQPSPSSKQVENKEDSSATQIEKNILQLLLDGLTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL9</accession>
    <name>A0A4Q9LWL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LNS2-like plasmid maintenance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0542p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000542">
        <property type="protein sequence ID" value="TBU13064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0542p0050"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="2">
        <location>
            <begin position="441"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="637" mass="73974" checksum="3BD2DE3ADB6643F0" modified="2019-07-31" version="1">MSFLKKIFTFTSPFKEPMITGSSDIIVIKHNNVYKCTPFHIRLAKPSMFRSQRIRTVHLIVNNRMTDVTMLVNNKGELYFEEIHSTDVYAHKNIDNCINKITEEDFEEDRCFSDTCVLPSTINANTSKNLDILLSNLSLASASTSTSTNINIVPNSISTTTESFSSNPSLTLNTRIKTTQKNLNKFYGINNSEVKYKTREKVRTKNYSLRLYNMKNKAHKFSPFLNIHFSYKYFGRFVESQEYKDHLIKEYHHLFDLLCNSIFPSGDKFTRCNYNNTDSICGTLRYSLCYYQRTRRGLKEAFESCITGDMHDTKGMIVELKGCLECKSVFYFTFKFFNEIFFFLRGILTSTEMKRNSRFSSNTIHQKKSKFKDFLIFSLQKKSWSFFGNKEKPQIHSFTLNSDNLKKLGLRNGKNTILFKVSGIDISVSANCYLWNNSTKIVISDVDGTITKSDVWGHIYSFVGKDWTHVGVAQLFSRIEKNGYKILYLSSRSIGQSRVTRRYIQGVKQNEWRLPDGPILLSPDGLFRAIYREVILRRPEDFKIACLKNVQNLFENTNPFFSGFGNRITDVISYKALNVPLSKIFTVDHTGEIGLEFKKNLSSSYLNLNEFVDSIFPVVKKDINRGYRDTEYWKIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM2</accession>
    <name>A0A4Q9LWM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0519p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000519">
        <property type="protein sequence ID" value="TBU13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0519p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020381898" evidence="2">
        <location>
            <begin position="27"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="500" mass="59340" checksum="12F56A6294E53026" modified="2019-07-31" version="1">MIILNLSRYIIFLNVLNVILTTVSDSLEVLKKANIKEKPDQVLMKNITEDKEKDSTDSKIRENSEKENPSLDENNKKTVKLGNIFNLRRDSDSKNNKSSTVKHTNNSSKTKKGISFIFVNSLDNPKNIFNENMPRFKNAHSFNPLEWQKIFTHLKDLLPLLQYNYLFNSITNTDTLYVHCRTFENISFNEIKIKKDTNITKKELQKNWELFDRKYSEINITDYNYPLLSLIPGISMLKEFIYKLLSNKSLEERNIFNIFVGMKMLESILVFSREIIFVLNPNHKIDIFNCDRRVKNILIEHKKIFFAILKILLAKNFCLSKEFFTNLRIIEIGCVCFHKNRQYWANEYHFYFLRALIDSIFLLDDELLNIVHGVFSDYVLNVSCHTGFVSLKRLNFFEIGKFKIAPQMAMKFIRYYLRMLNKKEFIMCRDLNEMIFRDIIGALTNEAEIIEKNGSTQENEHMDLLFRCISTFHFIIKFGFNRDIHDHYHLKMLSEYIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX20</accession>
    <name>A0A4Q9LX20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0472p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000472">
        <property type="protein sequence ID" value="TBU13308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0472p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="7042" checksum="3AB2A7181CC36A14" modified="2019-07-31" version="1">MYLVAYSQLIVYNETVETTYFDRKREFRASLSFIQAAERDQEQISSLKQAIDQEDFVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX93</accession>
    <name>A0A4Q9LX93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0370p0010</name>
        <name evidence="12" type="ORF">CWI38_0448p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000370">
        <property type="protein sequence ID" value="TBU03024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000448">
        <property type="protein sequence ID" value="TBU13388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX93"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0370p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0448p0030"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU03024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="388" mass="44489" checksum="8A730C519BC65B24" modified="2019-07-31" version="1">MKRVLGSAYFNLLKTILGCGILVYPSLYKNYGIIPTTVLTLISGFFSLSGLFLYVLTNKIINKKSTMSTISRYSIPSLRYVVDVVVILKCFFVTVSYMIFLKEIIPYGFGKLGFEYFVERKELGLLICLLISLPLNLLRKIDGLKFTSVFGIGSVIFILLTSFYRLIRSNSDKKIYYFTDNFSYYKSLGEFVFGFTCHQNIFTIQNEMEGVKIWELNCVMFMAIFTASLIYILFGIINYKIFGELIEGNFLNILDDDKLKIVTVVIYGIMILISIPLQVNPCRLYFLNIFNFKYSSGREFGKIRNIFTVVMLGISYLIAISNINFQKVVGLVGGTFSTAMCFIFSSLFFLYLKATHKNRKFKFLACIVLLWGILVFIGLFVSKLQDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA8</accession>
    <name>A0A4Q9LXA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0561p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0040"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38984" checksum="EC5C431DE4571993" modified="2019-07-31" version="1">MSKHLFRVRKCPLSEKSLEEAQLAKLYYEIEKRKLHSKLYNAKKNELVSVSDSSRWLKKGNIRPRNEAVFCYIQNRNVFWGANGMCQHAGTTRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSDLVQEIIDNEYAEIRVDTRIKTDVKIRNNRPDICILDKKKNKITLIEVGITSQDSLQIYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLELGLNAEEIWERASMGVIMGAEMHEEPTPPLKEEKREEDGGTTLEEPTNNINEESDLEEETAMVKEVEENIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE5</accession>
    <name>A0A4Q9LXE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0549p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000549">
        <property type="protein sequence ID" value="TBU13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0549p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="29854" checksum="CA8852A0F8A7A14A" modified="2019-07-31" version="1">MSFWDTQAFKISAVVVLGLILFALIIIIIGYCLAGNVINNFEDDFKNVSETDRFQDHLSKIINTNIAFFWIVKGAQIVWIVDPKDNVIKIKNKKENLRNGKKIKSLQIDLNITEETLDRANKSFRLFEFDASRFSKILQNFGFLVKFGLMFIKNHPVKEIHAAAKMFDKELNKDSRDNQTKMVILENLDFKNITIYKLRRTEDSEYDFEGAVTYLTFEPFQINDKVCVISDFITYILEKVYKDKNETNYHIQDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF5</accession>
    <name>A0A4Q9LXF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0421p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000421">
        <property type="protein sequence ID" value="TBU13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0421p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="757" mass="89900" checksum="00F9D8FC0778B0D1" modified="2019-07-31" version="1">MVKFIFPPSEIVTASISSLNVIQEFKFSIIDENRTKKNVLAFSSVSDENIFVVPYNGNIQIKFYTIEDLIRINRPLDVYINDIEKMSFIESYILLVCDASVIESVSFNNFCNIIRILDFLKSEITYLFWERLELLYQKLLNTHDHQILVVEMLEYKFKELHYLKNPYLIILLIFFDNISIFPRIENHIIELDSQSYMKEIYDLDLSLNEFIFVITGKALYSMYSRIKEKKNFNVFEWLVKNTRIIEIRMVYMNIKTVSAVFYGIFNTLLGANFDVIHFYKCLIFGEISELIDQRVKKLRFIEVFFFDTDLNDTFERNNMEEFVLQNCYVRNFYDKQKLKNSMDISKMMHRIHIFSMKNIEIKRIKITDAIITKEWCVALSLFTHLKCFHLERCDFSAIEQDFLSSLFLLCFDTLETLILMKNINIEFLLIKLRLFSEIKTLILRGVFKNVDIVELLYISLFMKKIVTLNLNGIFIKNVNSMYMFDYNNLKFLSLNSLNFIYDFEKFTKEFKTPAIQSFNLTNFRVEASRLITFGFMKNIISLRLICCGVNNSFLNILSLLKLDNLELLDLSENVFNDSVNTRILQLPKITTLILKKCNLKRFNFLLRFLKSVLDKITTLNTDSSLILVNNFLNIKYFSNLKELDLSNMNFESRIYASLLKHIENSKLEKIFLRYAYISQCLINVLSRFRNLKYIDLSHCSLTFLRIKITPIIFENLQKLNLSNSIICCEEFKKLFRTHGKLFLQIENESYDYFDKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK0</accession>
    <name>A0A4Q9LXK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0432p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000432">
        <property type="protein sequence ID" value="TBU13434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0432p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="10097" checksum="5040A66EF2F8ED1A" modified="2019-07-31" version="1">MSNIHALEPWNQSTELKKSAKKILLNEEENLADSNSKIPGKKYQWILYKEPKYLGTNTPLIHASNEKDDSDFTILDRGIDNIYTESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK5</accession>
    <name>A0A4Q9LXK5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0409p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000409">
        <property type="protein sequence ID" value="TBU13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0409p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="101880" checksum="0393DF68B21D2858" modified="2019-07-31" version="1">MNYKNWLVLPDTSSNTKKTNKMNIKYFTLNFSKIIRSVSFLPFIILLFNIGNCIRITISFTNEEHPKELPPLQPSSIYPKRRKHNPEISVNRKGQTLSNYKNKYMEQIKNNKYLNTPPSNKLKKSIDNINEGKGIIIKNSSGDGNYACLSTSRYIPWSEIIADDSNLTNSEDNTDISSEEHIDSITFDYSSDFIIRSKYLDCLNETNIEELHLNIKDITECKIDGVLCEMLLFILPSGLDFGFPNLNNENFLEFIWFLNDISCYSKYDALETFYKNLLPFLYSYVTYINRNMPEESREIFSIHKKQLFPFIAVLYDTIDLSFDENTNELTLQKKKENRKTILFIQNISHMFKFRTDPETLNIVQQDDYATQRNILTLIFNSYEIYRIKISVDDKYWAEGTNPVIESNASEKCLTISEIKNGFSSIFFNMNLNQKRSIKSVELERIVLTIKDMEFLNDLKVLETLVIVHCNLDCCMDFLWLLPSSFPKLKILGIIGYTLKNNFFENINLMNIRILNLSKCDYNDNPNNLIVKKNKYLNSLKMNSSCLNQKVFKSMICSDLLIDLSLRAVDFTEIKVDKDCFDRKKTFQFLDLSECKFNDEFLDYFLTDLKAKKLNLEYFPDFQHLIKILDQESLHLSTEFLSLSGNSLYVDLYISVSRFKVLKRLKLSHMNYMICNDFHPKFAFKHQLNAIDLSKNRLNKDSMIFLHQFNNLKELNLSNCNLETGYMEILFTEHLSNSLVELNISGNSFVSSDFFKIVYLKNLIRLTVSFDNQVFLNLEDKYDIWKFKKLRTLILVQTNIEDLLYKSVMTIKDIKIIEFQNCKFEDDVLSKNNNLNPISVENIILINTKISNDDINVLRKFKINGINVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL6</accession>
    <name>A0A4Q9LXL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0400p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000400">
        <property type="protein sequence ID" value="TBU13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0400p0040"/>
    <dbReference type="OrthoDB" id="2190892at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="639"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="705" mass="85226" checksum="D4EF788A4D498D6D" modified="2019-07-31" version="1">MENSFSLHLNPISVTTLKKYEEQLEALKAENFSLKHQLSQYFSDSSATKILQDAQLSLKILEGEKEDLKKQLENLKAQNLQETENFNNLNSSNEKLRKDNLELSEYIVELRRQLSGNDLSKNDLQNKFIQEIEKYKNENFCLKENYEIKVKELNNYFCNQQKKYQEEIVSLKNKYEERVGEFNNQMGSMQQVNQKLNNELNGLFSEKKFLGEQKNEIEKKFEIIKNENEKLRINLNENQNKFQNLQENIEKNKERNLFFEQENESLKRLNKNLSEDLKILQNEFDNYKRNTEESYKKMNEEYKILQNEFDNYKRNTEESYKKMNEEYKILQNQYEFILNNKNSGEIKANKMYLENQNLKLESKKLLEKNIELEKQTERFKKGYEELENTHEILKIENIKLSSALETLNNDLEKTKNYYNELENKFNQNKNLNEDFYLKYKNFFNSIVFILNEIENWVKNVEIKIDGFKKEKISNLNKFNSKLNTAYKDCERRIQEMRNSFEQRNKENEIKNDKNIKEMKERSNEEIKKIKEEFNLFNLTLQEQIRILENNLKLDEENIKFLKKFECREKDLKTIVNVFRKSYTELCSKIGILEKELGEVTYFQENTRNLNHRKILEMAEMFSKEIAEGKEQIIKCNDYLKKKNKEIKEIKLELRNCNSKIEKIELKSQKYKIEKEKALNSYNSIFQKLKDKENFIKKLEMKLYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT4</accession>
    <name>A0A4Q9LXT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0658p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000658">
        <property type="protein sequence ID" value="TBU12711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0658p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="767" mass="91747" checksum="091D48E108A39E1B" modified="2019-07-31" version="1">MFLYNIIYFLNVFGRFDLVTSCKFTYIFKRNLNEEILFFRENIEESVLYEEMIDFFSVTYIFNIESQFDNNMDTVFIYKKDNFIQFKDLNVFLASSSLENKCKSVKIQCGYELSYYLMISKDITEIPDEISNFQFRCMLMTLICLKAVENKNIIKLIRALLCKYFLYQNINKIKNEFLDFKEIFSSGFSKKINFFIKKSLISAFLDIFMVNYEFYDGNLIIFENSKKVYDVSLFDENIPYKNLLINNHTAFCILEHILEDSYILNNFKVLLYEMNIKSLILDNYRALIKPGIDPKFVILCTSIFKAIKISYFRSFSSSFLHNLACISKKDIDFLSLQNIVVSRDTLDLLLKKRNLKGLVLDNIAVDDNNSYFDDYLCLNDTLEYIFFTNVGINYMWWCGFFRRTNPRKIILIFYVSEVQNYFIEAFSEVNTYKNVLYLEILFRGFNISKEFCNSLSHWQSIRTLKLRDFKTNEDNEIFLLKTIEGMKELKYLAIQSNVIGRKLYCFLLRKCNIKVFELETCYLNKEYILFIDFLGNYNSLTKFALKRIKIDLSGLKEIFKIENLLSLALETCIVEPLRSYEPIDFMSESLKSLDLYGMHLNTRWAYDILIRLDNIESLNISYCHVLPDYLENLSEKCNLILKKFYYNHNSLYQMDLNRIKRFNTLEELNFYGCSFVKTNFHKLGQECKFFNSLKKMNLYLVRLTLEDLHYFRYFKNLKNLKLTLFGSGTIILKYSLIYQTMSQYLINNDLFERDRETFFQYLYELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY1</accession>
    <name>A0A4Q9LXY1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0364p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000364">
        <property type="protein sequence ID" value="TBU13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0364p0060"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="19102" checksum="F8BD64B43261A482" modified="2019-07-31" version="1">MYRINYQTVNSIRRDRRLKLTLEIKECLETYFDLEGIKTLLPLHSKAVKLVPEPQDQLRNCFRELVVNYDDKNFVFLNKVGRAVETRPSRGCNKRGESACLSYFGGRSNEQICMIYHKTYERIVNEKNLKLSNKEIYESCKQQKILTSIFVMNNARIQIIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE4</accession>
    <name>A0A4Q9LYE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative replication protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0316p0050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000316">
        <property type="protein sequence ID" value="TBU15132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0316p0050"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU15132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="26233" checksum="27CB46D461990C4A" modified="2019-07-31" version="1">MSYDDGGYIHSSPKREVSSSLRTIRSFTIKQILNSPVEEPSTDYRIDDVEVTNLQIMGFVRTTRVNTTGTIFNVEDTTGSIECAFWPRGLFEEETVGLIEPPNLLKVVGSIRVFNGVKTIGASFISKIDDTNFFIKHFVECIFQHMFYLKTLKLSKNVKKSENKSFAKIKEDIINCYRSNQDERGIHVDIVVGMLKDKYPEQEVRENIEALLNDCHLYSVEGLEYHTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE6</accession>
    <name>A0A4Q9LYE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Dcp1-like decapping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0312p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000312">
        <property type="protein sequence ID" value="TBU15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0312p0010"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="51103" checksum="9FC87062C619FFB4" modified="2019-07-31" version="1" fragment="single">MNDELKKNILKSVLNKKDKLFLEIIFSAEYCAIYNFKNDKWEDVNVEGSLHLYQRKSNLQKALYVFNRKGRNDILLNIENGCSYCLQDSFVIFKDYHYNFTGIWFSKIEEAKNFCENIKIISNENKISTTDSECKLYCPDDVSIRDNHSFNSETFQSISCDNIYFDESNSSKNFCIYENSSDKNDVLESEKAQLAKLYNEIGKRKLHSKLYNTTKNEVVSVSASSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLVIRCDKMLGDDYTRRHNEVVRCLHLLLINRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKNDVKIRNNRPDIFILDKKKNKITLIKVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIVLKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ3</accession>
    <name>A0A4Q9LYJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0319p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000319">
        <property type="protein sequence ID" value="TBU14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0319p0030"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="30540" checksum="49871DF8ACB5F81D" modified="2019-07-31" version="1">MVKNTNNPTLTSIKSFKKRIINVGDCSRLLKKANIRPCGKTVVCYTQDGNVFLRAERMCHGCGWSSKTVDYLAKRPKKILGKDMSRHSNEGINFAQLLFKNIYNFKSLKQIKSDSVPEILDNEYAKIRMDIMDKHVLENTSQYSLQIVETEKFSKYDIFAKIFPYVVTWEGIVTKYHKNYAKILQVPMYVEAYIQSIVLKKATENTNNISNLVLDSITSFADLKICANEDSDLEEGGEVIKTVEKNIKNEKIILPRILLNIMAMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ9</accession>
    <name>A0A4Q9LYJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0623p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000623">
        <property type="protein sequence ID" value="TBU12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0623p0010"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001546">
        <property type="entry name" value="RNase L inhibitor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="75"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="359"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="613" mass="68732" checksum="2F929E87DD7A2B36" modified="2019-07-31" version="1">MAKNIEKSKLTRLAIVNPELCKPFECNLECKKACPINKMGKDCIVVKKDSKISQISEYLCIGCGACQKKCPFGAITIINLPTSLEKDMSHRYTENGFKLHRLPVPRQGQVLGLVGTNGIGKSTALKILAGEIKPNLGKFKETPDWIEILDNYKGSELQGYFTKLLGNELESVSKIQYIDSVPKNLKKEFSNENLTVKEVLAVKDERNLKDFFLSLLSIENIIERDLEALSGGELQRFCVLLTCLKKSDIYIFDEPSSYLDVKQRLLVAKAIRSLSKADKYVIVVEHDLAILDLMCDFGCVLYGKAGAYGVITQPYSIKNAINIFLDGYVPTENMRFRQEALKFNISEKPETSGAEISYNKYDAMKKTWKGNKSGFSLNVEAGSFNNSEIIVLLGENGMGKTTMVGLIAGVIKSDDNNETFCGAKVSLKAQKILPKFQGTVRELFMSKIRVSFLDLSFITDVIKPFGIEYLYDRTVSSLSGGELQRVAITMCLGKEADIYLLDEPSAYLDSDQRIAVSKVIKRFIYNKKKTAFVVEHDLIVGTYLADKIIVFDGEPGIKGNASAPLDIVNGMNKFLKNLDITFRRDPENFRPRVNKPNSAKDREQKENNKYFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM0</accession>
    <name>A0A4Q9LYM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0600p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000600">
        <property type="protein sequence ID" value="TBU12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0600p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="49633" checksum="292452DC43C0BC0C" modified="2019-07-31" version="1">MLCSTKLLLLVQENVAKNRLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENDNKIHHALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDYLATRCEKMLVHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYTEIRVDTRIKTDVKIRNNRPDIFVLDKRRNMITLIEKLRKYDLLANELGLIYRCSVEIIPYMITWDGIVTKYDKTYLKRLQIPINVVAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSGIIGAEMHHQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKLVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA7</accession>
    <name>A0A4Q9LZA7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0346p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000346">
        <property type="protein sequence ID" value="TBU13746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0346p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="8">
        <location>
            <begin position="503"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="566" mass="65362" checksum="B77AD12614F60193" modified="2019-07-31" version="1">MKVEETDKYLKEFKDVLLTVSEDYTKRIDNIIKKYVNVNIDSGLENEKNVKKNKNNFIFKENENNKKVKTIGKGDITNGCGKVKTIGRVNRNIENTGNNNSRLNTNNNNRVNNSRLDTNTNNRVNKMDNSRLNKIENKMDNSRVNKMDNRRLDANNTYNNRLDANNTNNNNRVNNSKNPNNNKENKRLNNPNNNKVNNPDNKMNNTSNNPSSIKENNFDKNLISKSVKKEFIGGGIRDVNKKEKRSVEKVQKIKLNIKTPLKRGSFIDEGVNVDFKENKSSFSILHENIKDFVEEKVIKEDISSECQLDMMTSNNSLNFNENKFDLEKNVKNKLQIENSLMYKNEEEDNSGLTIFDLKNGDLKFDLSDSIVKVNEELDNLLAQFKTEIEDDRVLNVERCEDDKNLVVESTESKGFENQNVFMTNGSKTKNTIEKSSNTTFFSSGSPDSKDSSLIFYKRTPVDSLYKSVIDKQIRNSSAFRNSIRFDLNSYKPKTVVPVVKLNDEEDLLDNFKLPEWAKDTNLNGIVKQQSHIDLEKYFYYLEDLDVKKIFPYCSTATNESPNKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE8</accession>
    <name>A0A4Q9LZE8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0233p0040</name>
        <name evidence="10" type="ORF">CWI38_0359p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="PITK01000359">
        <property type="protein sequence ID" value="TBU13694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000233">
        <property type="protein sequence ID" value="TBU18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0233p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0359p0010"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="37137" checksum="7FA2678DF052B51A" modified="2019-07-31" version="1">MNYDEVNVDTIIEKLLSVKSCKPGKQVNLEEIEIKYLCEKSQEIFMRQPTLVEIKAPVKICGDIHGQYYDLLKLFEYGGFPPKSNYLFLGDYVDRGKQSLETICLLFSYKIKYPENFFLLRGNHECASINKIYGFYDECKRRYDNKLWKIFTECFNCLPICALIDNRILCMHGGISPELKSIDQIRSIVRPTDVPDVGLLCDLLWSDPDSAVNGWGSNERGVSVTFGCDIVQEFLDKHELDLICRAHQVVEEGYEFFASRGLVTIFSAPNYCGEFDNAGAIMNVDEELVCSFQVLKPTPEKLFNSGISAQHSKKQLTPPRPSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH3</accession>
    <name>A0A4Q9LZH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1041p0010</name>
        <name evidence="4" type="ORF">CWI38_0151p0030</name>
        <name evidence="3" type="ORF">CWI38_0324p0020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001041">
        <property type="protein sequence ID" value="TBU00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000324">
        <property type="protein sequence ID" value="TBU14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000151">
        <property type="protein sequence ID" value="TBU20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1041p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0151p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0324p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="162" mass="19164" checksum="838E24E7CDB1CEBE" modified="2019-07-31" version="1">MGSNRNSEILDLQNKEEGSIFEINGSNCIENVNKYKEPYIIDIQSGILVKQIDLLEIKTPYFLKNINENIFPKENEKIENHQSDKKEEIAKDNPYKGHSQGANVNITQYYVRQSTNCYSSFIYWFILFYIFVIAFLMFYLFYSLIQDFSYSPLVYNDYVDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY6</accession>
    <name>A0A4Q9LZY6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0180p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000180">
        <property type="protein sequence ID" value="TBU19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0180p0060"/>
    <dbReference type="OrthoDB" id="2196034at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="45103" checksum="059590074C570630" modified="2019-07-31" version="1" fragment="single">MKNNERRELTRFYDLIKRKDYKKIEMSLNTISKINATAISDPKDLDLLKQYTKNKEILKIIMRNDIKFLLCNKRKIHKEMINTVLYLDNAYIKEIKDIIIDNIIIQKYENYVYSMKSNIRKLCELKKAIDWFENSLDSLRLNESDIPPQWNLEGDFVFKFCVLTKQIICNIIFHNNIDNKDYLDGLKYILEFEKKYCNHIFSDNCCENNNNTNNDKNKKIIFKNTGVELVEDNKSSLNDPLDVETDTKITKKDLEDLKKNCKHRKMLSQIFIPYIEIYVKFLFIEARKIEMDQSKKEMKIVCGFIEFFRIIGEIFLEIQYFESEKIYEYFLAEVNSIAIRFIEKIEHKRNFKEAVLILNTFSYVESTSVDLFKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M038</accession>
    <name>A0A4Q9M038_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0161p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000161">
        <property type="protein sequence ID" value="TBU19974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M038"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0161p0050"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="49580" checksum="186AF727663AC33A" modified="2019-07-31" version="1" fragment="single">MSFVPPVISTTSPPRFIFNIFIAPFIFHSFMFDNPKLNMSENKCLNTFNFIFPSKFFIVINYKNKTISFYLNISFPLKELGRGLQSVEFKSEHMLLQLLDSAILKVWNNNKTHISLIKNFLKINYEREEKVTKKKLYNERKNELVRVNDTSRWLKKGSVRPRDEVVFCYIQGMCHHCNQSRKTVDHLATRCEKMLSHDYARRHNEVIRYINLLLLNKYKFKSSKRIRSHSVQEILDKEYAEIRVDTRIKTDVKIRCNRPDIFISDKRQNRIALIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWESASMGVIMRSEMHEEPTPPLKEAKREEDGGKILKTKNNTPLISQGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M054</accession>
    <name>A0A4Q9M054_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0316p0010</name>
        <name evidence="6" type="ORF">CWI38_0286p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000316">
        <property type="protein sequence ID" value="TBU03309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000286">
        <property type="protein sequence ID" value="TBU17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M054"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M054"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0316p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0286p0010"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="60"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="367" mass="41450" checksum="8A4902F6A2F79782" modified="2019-07-31" version="1">MDRIKEIENEIARTQKNKATAHHMGLLKARLAKLRREQLNLPQNKSTVEGGFDVSKTGIARIGFIGFPSVGKSTLMSKLTGTYSAIADYEFTTLTTVPGVLKYRGAKIQILDLPGIIEGAREGKGRGRQVLGVAKTCSLLLIVLDCTKPLTHKKVIERELEHFGIRLNTKPKNVKINKKEKGGITVIYNYNQSKDEDAVEVEIVKGILTEYRINNAEVVFNEKCSVDEFIDCVDGNRKYVPCLYVLNKIDCIGIKELDLIYRIPNCVPVCAHLGWNFDDLLSKSWDYLKLIRVYAKPRGMAIDYEDPVILREERKKIEDFCNSIHKSIMSKFKYALVWGTSVKHNPQRVGKDHVLNDSDVVQIVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C3</accession>
    <name>A0A4Q9M0C3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0137p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000137">
        <property type="protein sequence ID" value="TBU20070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0137p0020"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="84"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="282" mass="33235" checksum="C0C59B9EBF66339F" modified="2019-07-31" version="1">MKTLEDRIKSTSTLILCFYLHILTQVIYLLPDNWNKAKITYITIFNVSCTMIYIYLCLAHINKGFVIKMSESELYLLGGDITRNGKFCRRCDLFKPERAHHCSRCQKCIKKMDHHCPWIGACVNHDNLGYFIRFLFFGASSNILLFGYLMCIFVRKINEKKFQFGIFYTGMVFSLLLSFSLSFLLTFFFIFTFRNATKNITYIEKLRYSDLKKYGMDINDNPYDRGAYKNIKDVLGKPKFLFLCGEKQNGIFYEKTYPCSEWPPYKFGRSVDENQIKDSDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C7</accession>
    <name>A0A4Q9M0C7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0135p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000135">
        <property type="protein sequence ID" value="TBU20084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0C7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0135p0030"/>
    <dbReference type="OrthoDB" id="2192876at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="27523" checksum="8DB6A75FF9EC4E2E" modified="2019-07-31" version="1">MKILNVNTAVYKHKPNKNSKIKEIAYFMVPYKTDCYICLDFPDDPKILECRHILCEVCMEDCYMFYGFCPICKRTISKCFSVRWLFFTDYNIGDKIKLVKIDSSSLFDVPHIDVYSKKPFYDSYYENITQEDSKSKICKNISSVVSSKNIDIKKVNKNDYKKIPFYQSEDGQLIFLNPKSLKNLIFKHKIFKDLPEYIILKIYYIESYLDSTNYTFLEHLDSKCISFVYGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S2</accession>
    <name>A0A4Q9M0S2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="1">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0361p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000361">
        <property type="protein sequence ID" value="TBU13690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0S2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0361p0040"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="6"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="395" mass="45559" checksum="7F89C80868F07470" modified="2019-07-31" version="1">MQILVLGSELIKLLITQKEYKITLLDYDEIEISNLNRQFMYLKKDIGKNKAEVLCSNLNNRKNKKYKYINTDVLKLKEEDIKHFDIIISCLDNIVARMHINFLIKKSVKNIFFIDSGVENMKIHVKVVKKGFSCLYCIKEMYNTQVNLSFCTIKNIEKNLSKYSRHQIILSLIIQFKEKAKENLSYLSNNLPGDLTKDLSNNLTKDLSNNLENNLSNNLTKDLESNLSKDLSNTLESNLSKDLSNTLECKLPKDLSNNSTKDLSNNLENNLESNLTKDLSNNLNKIISKPNKISIDSNNRNISNFIESVKLKFNELALSNNLKPTNSFEIIGIERDIIPNVCYINSIAASLIFKEIKSIKSNKEYDYIFYNSEYKIYTQKFLLSKSDSCILCNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V2</accession>
    <name>A0A4Q9M0V2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0372p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000372">
        <property type="protein sequence ID" value="TBU13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0372p0010"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="39"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="322" mass="38116" checksum="4FB658D23953977F" modified="2019-07-31" version="1">MSIISIILVKQNYNKDKNTTKDKLESSENILECPEKNIVGLLNHDYVCYFNSIIQALYYQPNFIDKLFSYSSNEHQICIILLKDIFAQMSEGKIVDTSKYLKKIIAVTQWRKIFEIGKYQDASRCLYIIFDQIEKEIINTLPLKYREIVDITKIQSNNFISNFFRLELTYSSYCSYSKETKTYKTNPYFLCLFLDKSVQESINKYFSIHKSVCENHLDESELHCEINRKEIIVYSSNIIIKHSLFPPTTDVLINNKIIIQNFEYIFTACIFHVESVHYYTVVVSETSIYELNDLKVKKLNIQSIEDLESKDIPYFLFYRRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M151</accession>
    <name>A0A4Q9M151_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0081p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000081">
        <property type="protein sequence ID" value="TBU20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M151"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M151"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0081p0020"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="369"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="582" mass="68081" checksum="105DDF36D402CF75" modified="2019-07-31" version="1">MIIISKKHIEVRKLENITTAGLCIKHDQTILVFIYREHSSSEEKILNEELSSYTDANIICIGDYNLEQRANLEQDVLNNHAKYGLAEVNLHTKTFIHNEKSSTPDKVFANCPVITDIKTIENINHKLIVALLPKAQKCEPPKYKINLIKNSDIRNMITKKIEQYTERSINILKFLNVNNKCLLLHAILIKSMRRIERRERLHDRSNPIIQHVRKLRDKARKTNAKEYDELRREVKKLAKRFDNSSLPRTNLRYTSLQASELEKVILFNGKTERKHTKNIRELLDSFILDGNIKETEKTIKEIKNFYGKTNMKHNYNQQDMITSFTLAEVSAMIKNLKSGKSGGITGIRNEFLKICPENFINELTNLYNAILDTQQIPDSWKRHKIKPIPKDKDNFRPIALIEQTRKLFEKLLLTKIDIKLHRQQTGFRAKHSTINHALALDTILRHGNGKYICVTLDIKKAYDSVFRKNLYKKLLRQQNFSIKDTTLIANLIENNSYTICQKNTGNIKFKTAALDRFKKLNKENLRVNFTIFQEIELLKKYNFQNSNKANFERITRILSPFRKEQEISEILNLFQVANIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M167</accession>
    <name>A0A4Q9M167_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0082p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000082">
        <property type="protein sequence ID" value="TBU20375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M167"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0082p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="68" mass="7943" checksum="38389AEE348260BE" modified="2019-07-31" version="1">MHDEPTPPLKQARGTTLEELAININEESDLEEETIMVKEVEGNYKNYREVLIQNFIKKVYLLPDLNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D0</accession>
    <name>A0A4Q9M1D0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0174p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0060"/>
    <dbReference type="OrthoDB" id="2188446at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="51889" checksum="020E6E12BE6E5FFD" modified="2019-07-31" version="1">MAKKIISEYKIIEDKRNIKIFNINDTKDIKDLREVQNINDTNDKLKTIKSKYNDKYLEINTKINKCAIGYINEKMYVGRVYHNQKLIVIREIDGFYFMRPKYCEQTSKEIKNGFVMIKSESKEKFEFRKKSLKYVLDRIENEKPREYKYCRSEDKCDYNAFPLNNNLNDSNYDNITNITHISNINDNSLSITTRNDSFKISQHTLHMKNELIKTIFRLKVINISIIKNIFNNLDGILEIIKEYCMVCRGRYILKDKFYEECLQDNRKIIIQQLKEKGYLETKYITKNNINLVVELCIKKNDIYLLKGEEEIEEIEETNNKDENIIYEIFKEVGICSIEYVIVKSGMEKEELIKILNNLTYKLINNSYVLKEGEENEIRNIFIAIFMKKRSFKRNEIFEEYFKRFNKELKIGVFSKVSKEFCTSKGGVWYLKDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M227</accession>
    <name>A0A4Q9M227_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0214p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M227"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="15629" checksum="04704BF946758FD0" modified="2019-07-31" version="1">MSKEAVKAQGIVVVRVSVRGGGFLVIIRVTSVAIRKCIRFCMEVINKGNLKLYCLEDNTCMGVLIICRCVSRVYDEGVSNSSMLEGVNYINSSILEGVNYMGVSNSRVGILEGVSYTSTIDKRVIVGVSNNVNGYRCVSNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M260</accession>
    <name>A0A4Q9M260_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-like endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0024p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000024">
        <property type="protein sequence ID" value="TBU20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0024p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43464" checksum="0E7B3692D9C46E92" modified="2019-07-31" version="1">MKAVYKYKNLYIFFNSILNCFLITENVLLDEYGKCEGNLLNLERRDSKYKQLTKEQPQGILEKLLQQIEENKLKHGAIKKVSCTFEGKICADVSSKKKKRCGRKPKEYSNNLAQIKNTLLNRRGTLRCLSFAIDIPKSTLFDIFKSGKYIKRISSTVKPTLTDKNIMDRLKFCLSKVNLANNGYLLFDDLYDYVHVDESARPRYDAHRKLYFDGKIGIWPFVYQEPTQRNSKNRAKGTMITENVESVTASKPYFSDNDANIIALGSAEDWNIKFTAQPVNSPDLNILDLASPHTIDDLINCFHYGIHQLEANTLDNVFTTLQACMESIMLADGGNRQLLEKYVHSKEAYNNAKSNSSELININIYFFKFYNIYINIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2A9</accession>
    <name>A0A4Q9M2A9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0219p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2A9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="16099" checksum="3E94D171A16C70D6" modified="2019-07-31" version="1">MQFSNLIWNDCIFQYAYFINCADEQEEPLLEHMESENNHKDDHKYQIYSSIRNFSEVILKKRLHKHEHFIDKYHIHCKMNLNQIDTNSESIRITMNDQIDYSRNYVLAWKLDPQYNMSDFIAEMNHSIFICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F4</accession>
    <name>A0A4Q9M2F4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0170"/>
    <dbReference type="OrthoDB" id="2193322at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9176" checksum="7757144F687DC813" modified="2019-07-31" version="1">MPHTISDDDLSLSLLSSETDTPIKLADSDSLDVSYDICYDNIIKIHEYFDKDLEDQKELIKRLEEFNKKLDKILEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G3</accession>
    <name>A0A4Q9M2G3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA replication licensing factor Mcm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0083p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2G3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0040"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="5">
        <location>
            <begin position="222"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="603" mass="67744" checksum="5531F82395A533AF" modified="2019-07-31" version="1">MENIKDLFGKQEINLIELCNLNPELANKFVLNTSLYKKNLKSKSLYGIPLALLLNVFPKANDISKLVSIKGTIIRSSNVLLKNVEYSIECTECDWKKTVLSETDITNVCETCMSNNCITKQAFDNAIGHQTLRIQDIGNPDTLSDTLEISAEGKWSGRFFPGERILVTGIVKVNMINNKVGEKIKSFLTLHALNIARIDDIVLTFQEEKLFDEFKNYDDFKKRETILKSFGSHIYGYMNVKLGLILAIIGGNNNLGFSENKIEINETENRKSNNIISNDENKEKLNENLNGDKSFVSFKTDRRSSSHVLLVGDSGTGKTQLMGCCLQIIKPAIKTNGLGTSDAGLTTCAIKQGGEWNLEAGALVLADCGLCCIDEFNSLKTNEKSGLLEVMEQQTLSVAKAGLVTCLNARCSIVAVCNVNNNFSLKNNLPEFLNISSPLISRFDLIFGLFDDKNYQNDIKKTDLVLSRFTVHDEKESAKKSNLWSLATIRSYIKLIRNNKIETNFGVNNILLKYYNYKRKTKSNTEIITIRMLESLYRLTEAHAKIVSRNVCTSEDAYISIFVYESGISCNKICKFDSDRIFIEPAYFKGKTNELISLLEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G5</accession>
    <name>A0A4Q9M2G5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0117p0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000117">
        <property type="protein sequence ID" value="TBU20188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2G5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0117p0050"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15306" checksum="53629E5DC8ED4E8F" modified="2019-07-31" version="1">MVISHGYGRVGKHRKHPGGRGKAGGLKHLKTLFERYHPDHFGKVGIKIFHRNKNAEFSPAINVDKLWSLIPEDVLPEFVGNESVKAPVLDLKRFGYFEVLGRGDLFYKKPIVVLARRFTKQAEEKIVAAGGKCVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3B2</accession>
    <name>A0A4Q9M3B2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0060p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3B2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0080"/>
    <dbReference type="OrthoDB" id="2217172at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="157"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="295" mass="34018" checksum="2EA4AC3DC0FA9C68" modified="2019-07-31" version="1" fragment="single">MSNSFLGKNTKKNKYDFHVGETPECTECENDNVVKCLVETSGSNDENLFITTIPTRRKQKVSINDQERIIEKILEGYSMLTLEIKESLQTYVDLETTKTLMSWQNGTIDRALREFHYTPKRVKLVPERRNTLSTIKLRTNYATSFRELEVDNDDKNFVFLDEVGFAVVTRPSRGRNMRGASAYLSVTAARSRNISVVAAMNKYGMIYHKIHERAVNGEDFKLSIKEINESCQRQGISIPIFVMDNARIHHYRGLNDDEEIASYRLKYLPPFSPFLNPIKNVFSVWKNKVIRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3N2</accession>
    <name>A0A4Q9M3N2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0980p0010</name>
        <name evidence="4" type="ORF">CWI38_0128p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000980">
        <property type="protein sequence ID" value="TBU00515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3N2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3N2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0980p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0050"/>
    <dbReference type="OrthoDB" id="2190652at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="103870" checksum="613F1DF574BEC1B6" modified="2019-07-31" version="1">MCKHVLELLRLKETITEESNSKTKYKMFSYCLEKLFIDSLNSPMVVKLHTLDPLINYKFTHLICVSTKDILESFQNKYSYLSMVYGESIYFYKNNDFPLIDFLKWKLQNSLTDTELSRNKYAYSKFIMFNYDEVEKLYSFLAEQTKVRITIDKIYFNINQDIVKVGNSNRFLVKNYDEKYLCLKNTCFSVKQFVFPLPNAFKNIEVLDLSGNFIKEIPRDFSEFRKINYLNLSHNLLENLPTFLSDFQFEELNLSNNRLSKIPFLNSKTLILDNNLIEYFQQRDSIFDKISLKSNPVKRFFSKAKYLDLSFTFIKNIHVTFGEDIVEHLILEGIKIDYFKGNFSNLKYLNMQNCNTSVFSIEAPHLSKLILRNNLLTEFPFFPNLEYLDLSGNLLTFIESKILNLKKLKILDISRNDIINPNAYDWKWLEKINILYNQNNTNNEVLDVIKLETYYMNERNCILKETSNKHINHSFEYVKNNNRYSIFLQGNSETVKLIENNFEKYFFEICLDKDFMINTKCFYNHIENILIKKCLDYNFNIVIIFVVNNCVRISKKGNFMVIFYDSMFFKALSSKNNQIKYNKEYCYIMNDTMINNTKIEYMRFETVTDYKILILNDHWRNIIFSKELKQINLCKNLSENISMIYNFLIYTYPLDKNKPDDIFIAMKTSSSPIIFKDVLFTAEPIIVYAYLDKVPGFFKSASLEFYSLCRFIQSYIVNINGRFGAIQIKYEGDLCICYFRNSLDAIMWSVNLDYFFSSKLWKDDFLKRNPNSITEHKLNDNFLVRIGICKDIGFFDRNIEGDVDWYGQVLNKSARLAKLNTDINILISENIYTEIVHLNLSQIEFKKYENYQLKGFTEMENVYGIVKINIKSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M595</accession>
    <name>A0A4Q9M595_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0026p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M595"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12971" checksum="FC5DAB486DF7FD4F" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5M1</accession>
    <name>A0A4Q9M5M1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0013p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000013">
        <property type="protein sequence ID" value="TBU20881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5M1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0013p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20324" checksum="D7F419B2DC314685" modified="2019-07-31" version="1">MCFEPRDEAVLCYIQDGNVFWESRKCKMLDNDYTRRLHETYDIYTYSYQIDIILIQEILYNEYVEIRVDFRIKTETTPSEIGITSQDSLKIVQTQKLRKYDLVANGLGIFYKLCGDNSLCGGPETVFSERASLSVILVAEMYKQPISALKQVDMEEDNLKYTDHPQYTHLGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW45</accession>
    <name>A0A4V2JW45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2555p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002555">
        <property type="protein sequence ID" value="TBU06542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2555p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="21872" checksum="87CAE5AD36987D4D" modified="2019-07-31" version="1" fragment="single">FILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVENISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDVEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX91</accession>
    <name>A0A4V2JX91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1523p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001523">
        <property type="protein sequence ID" value="TBU10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1523p0020"/>
    <dbReference type="OrthoDB" id="2195775at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="355" mass="41128" checksum="31D98882879E51D2" modified="2019-07-31" version="1">MEKYCLILIICIKHIYTSELEYFLNTDIKIMFSAYEHFHLALKTADSSKYPFIGISRHLNAKEYNFDDRARITKNSDRYEISIGEEMLCKEKKTIIKCGETGNSAWSIDKRDFGYTISQDKMCITKKDSDEIILSKCSDTEDQLFDFKRSAGIGKCSENQDVSQKNEKMSKQNKSDTSKKSDNSKKPDKSKKSETKKKSYTNKRSKKADEESTSDSKDQEDSKISEEKDQTKISLSLDCKGDECKFRRISGNKNNSKPDFNDFRSLEDSNSFQDLLIPIETPRNTLLPGIQNPYRPNMESYLIPNNQNFIQENVSLYTNVPRPFKSHDVSNLKYPLSSSEIERGMKKFDSFFFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD4</accession>
    <name>A0A4V2JXD4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1243p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001243">
        <property type="protein sequence ID" value="TBU11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1243p0030"/>
    <dbReference type="OrthoDB" id="2193727at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="78048" checksum="ADA0F0B38703AEC0" modified="2019-07-31" version="1">MKVKEIKTKVTHKRKQKNKNEVKKHKKNSENRDNRTKEDRSNRGDIIKSRREDGRQDKQSKERHSKERHIKDGHNIQRHRKEGHNIQRQSKEGHSNERQSKERHIKEKHTKDTSKPSKHNKERGNKDKHTKDIPKPSKHNKDEKTKENRKKNSNESLDDVESDVKKEWEKARLKNISSSERNISINLIYKKMKGKFSKASRRRDFSKLIQSLIKYGNVEIYTNIFEEIKDKIIELTCCRYGRFIIEKFITRNFKIREKIGNIFKKNCKILICDRIGISIFNNLYLSLKYHERNEIIKSLMGNEINLLFNKNKLDEIPIEKIKLNEIYYKITRKGITNYQIAHDIIFYHLKTLNENEQEAVLKELKEFMVDLLHTRSGIKISDKILLKSFDKKEILKNLKPYFNKIVMDSNGVIFYLRVMSICNEKDLQKYFYKNLRKNFKELFLHKNSSLLYFYILNKEKKYFPMLFNEIQSENEIINFEANIFNKSNNKLESKEEDSKAKEINDKEIDTNEINDSVINSKETEVKDKEINNKVTEVKDKDTNEILKKETDTNNKISKNTTAFLIQKMEKYVLKNLKNCILNERFIIVVELCKRNEEIFKEVIFILKEEINKNILNDNYGVMFVAALKKVMNLEIKDIIDSKWNERFPFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH5</accession>
    <name>A0A4V2JXH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0993p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000993">
        <property type="protein sequence ID" value="TBU11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0993p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="11055" checksum="FD535014DA09B02A" modified="2019-07-31" version="1" fragment="single">TISFDRRRGLESKPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ8</accession>
    <name>A0A4V2JXJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0914p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000914">
        <property type="protein sequence ID" value="TBU12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0914p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="11365" checksum="D2E00B5E49BE5065" modified="2019-07-31" version="1">MRFVEFDLTEYQIIHNDLKHNNILIDEYLDIKICDFGISCYKKELAFPFKTLPPTDLEKYIVYSPELKKSEEYDEQSDMYSFGILIYFIFNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK1</accession>
    <name>A0A4V2JXK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0893p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000893">
        <property type="protein sequence ID" value="TBU12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0893p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="57752" checksum="C0F515813B3BCE0E" modified="2019-07-31" version="1">MGECFEDEINVLFESDSKEMPIYSYKKYGKLLRIESSIIEKYKKEKRPYYNIDCIYYYYIHNNRVIKNILKDIFIRIFQIGILIILIKIFNIDSAIKSKFMVKMVKIILFIFQTIVSVVELVEYYRKFMMFYTGYVYFKYILKIKPNHGFKKILKNIIHIEKKINNIDLTEEEIRRMLLRKYYFYRKFVANSVFKNVFYKNIFYTKFFKNIVQILVSKNEMSKSRNDKIDIHYLAILKKRFILFSFILLVISPVILIYNFIFYFVKILRKTLNNSNYLIEKKLICKFEEKESYNQKLYHEKKNKIKRKKIIYKKWVNQRYEYKYECLYYFVSNFLQLFVIFYMYDLIRCLFLYINEFHPNVNKQTAIFGNYISDRLLLRFLFLILTIFATNRLKNLYEKQKINKYSKKSKRFDSSKYMFRFNLVILFIELIAPIIVPLLMLIIFLKKEQYNAFLQEYLNYTYKANINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL1</accession>
    <name>A0A4V2JXL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0873p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000873">
        <property type="protein sequence ID" value="TBU12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0873p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020775458" evidence="1">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="38356" checksum="D457D218DEE33779" modified="2019-07-31" version="1" fragment="single">MVIFYWIVFINYMLSAARRNSKPTKALNKTTPPKPKTKSRITYLHDIAIYLKGCNSLHFRIENHKELNSIATLFAEKYNLKEKIIPRLIAKVNEYKDIIFEKDVRKFYLICFIEINIFLKEQKEELFYKKTDLNTNMFYDKVFEFLKNFTFSNLDDIETNLPEYVYNQMERVLAKSVGQKINSEFVESFISKLKYIDSDENAVIITYLFNKYTKILFKILKYFDEYHKARKFLKNGESISLSTTCGINGQITFNKAIFNAEFLEKGYDNLVLLDKLTALICNSSVYLSEKICFNGLNKQANHDQFDLFFDGFDTYNLFELNTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV3</accession>
    <name>A0A4V2JXV3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0501p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000501">
        <property type="protein sequence ID" value="TBU13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0501p0020"/>
    <dbReference type="OrthoDB" id="2195270at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="179"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="312" mass="36358" checksum="37A0C231D1B888E9" modified="2019-07-31" version="1">MSNYFSSETPECLKRENDNVLKCLVKKSGSHDENPPLTTIPTLRKQNVSINDRERIIENTLEGYSMSSIASMYRINYQTANSIVRRYLKTGLVFVDKRGGDRRSKLILEIKKSLQAYVDLECTKTLYDTIDRALREFHYTLKRVTLVPERRNTLSTIELRTNYVTVFHEFEVDNDDKNFSFLDEVGRGRNMRGASAYLSVTAARSRNISVVAAMNKYGMIYHKIHERAVNGEDFRLFIKEINESCQRQGNLTSIFVMDNARIHHYRGLNDDQEIASYRIKHLPPYSPFLNPNENVFSPQLRKLIYEKFNEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY9</accession>
    <name>A0A4V2JXY9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0967p0040</name>
        <name evidence="12" type="ORF">CWI38_0379p0050</name>
        <name evidence="11" type="ORF">CWI38_0384p0050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="PITJ01000967">
        <property type="protein sequence ID" value="TBU00568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000379">
        <property type="protein sequence ID" value="TBU13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0967p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0379p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0050"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="4"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU00568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="325" mass="37248" checksum="FDC95ADEE7E42034" modified="2019-07-31" version="1">MTILKEKHIEFLTKETQTRNFLYFSTKPLRLATIYWTVCALKMLKKTDILKEKRNEIISYILSCQNTDKGFGASKDFPSTILSTFNALQIFYILEYLYFDKKTIKYILSNFDSSDGSFKNDTGGEKDTRFSCCAILSLHLLFLFNKYGKFVFKKKLNQPIDYKYIKYLEGKGFNVEKFVQNILNCCNPDGGIGSKPGSESHAAQIFCCISSLRSLNLIDIIDLEKVKKFLIFRQTENGGLNGRPNKKEDVCYSFWVFSSLVMINSDDKIDKNSLKEFILTCQSEEGGFSDRKGHEPDIYHTMFALAGLYLLGNTDLESIDPGFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY51</accession>
    <name>A0A4V2JY51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H2A/H2B/H3/H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0204p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000204">
        <property type="protein sequence ID" value="TBU19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY51"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0204p0020"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="30873" checksum="60AFD8A9CE562C40" modified="2019-07-31" version="1">MITLIEVGITSQDSLQMYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKLHLKRLEIPMNVEAYIQSIVIKMTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKQASRGEDGEEPPININEESDLEEETIEVEETARKSTGGKAPRKQLATKAARKSSVAPGTVALKEIRRYQKSTELLIRKLPFQRFCRAITQQFKTDSRFQASALASLHEATEAFLVGIFEDANCCATHAKRVTVMSRDIQLVAKLRGRELKAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD7</accession>
    <name>A0A4V2JYD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0033p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000033">
        <property type="protein sequence ID" value="TBU20693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0033p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="35861" checksum="E3E6D1E27C0E9F67" modified="2019-07-31" version="1">MLEEMTDEVKKFLNNTVLEKPNIVSHKGLVCFSYLGIIYDSRGITTCKSFEEVQGEMILNFISAINQHAISLINYHIGIIRLEFADFSRLDDKLQTAGSLYLSRAELGRGLYNVELRNGDMLLQLLNSWGKCEENLLATLFNEIEKIKLQSNLYNARENELVSVSESLRWLKELKCDHVMKQYSAISRIEMYSGAQNPRYEKMLGQDYIREKINLSGNWIKIDVEIWCKDSIYLFLMEQTQYSLIEDDLGGIGTKYYNSLLRRPQIVHNDGTVETLSSYRRRRLDLQSSLIGNIKKAEMQNNQYTFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG8</accession>
    <name>A0A4V2JYG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA replication complex GINS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0003p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0080"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="30756" checksum="1B03039F4D850E80" modified="2019-07-31" version="1">MEPDTLKLIAHHNYYIQIETTANIPPIHLLSYTIPPLKPLSTYEVPLYIALSLKNSNMCKIKLPSSLSLPHLLSTLQFEISNTSEYSTLHPYFFETAYTIITNSYNVGHENGSTEEFREIKSYSNNNSNNGLNTNISNNGLNTNISNNHTSNISNITTHYLYKLVLDIKDIRFSKTYNGIHQIDTNSLNLNNLTIFEFNEIKHLLLSNMEIAKRIKGISSSRGLVSISSSRGLVSISSRVSGLNSKGVLVVGGSSSSKGLLGSSSSRGSSIGKGVAVVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL1</accession>
    <name>A0A4V6MVL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1338p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001338">
        <property type="protein sequence ID" value="TBU11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1338p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020833931" evidence="1">
        <location>
            <begin position="16"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="638" mass="75851" checksum="013DB2103CBE983E" modified="2019-07-31" version="1">MLILYISLLFETVLASHTMMSRGIVLCGRRWPMNFNNRNMRFCQITKPLYSGNTKSVGTFQEKKPGDMFCGRIETVESMTEKEHIGGNDPEDSYKKETESFESITENEIGLKNIKRRNIMFWNSVLKLKFNLNISYNLISRKEEINTLKNLEKSIIKLFFPYQAFTMDINKDKDILKNKIFKFDKKIFCKIEDLKNKVDYFITEEKLISKVNDCMNISENNLILKNYIEGDKYFLSFEKLPEVFNKLEFTDPLSWAEFFHDCDDFDLFLSCFYFIKKSFLVDNKFEEKICLTDSDFKDMKKFISDLKSNIFSDFDFKSVSTFKYKKEKKESVDSKYGVSNDEYLVIYILESIRTNKFVYPSEDRKKEKDLSIFEKYSKNLIGLNFQTCLAIKNFVENFLFEDKNIKKENIRKIMDLYDLIFVINCDKYDSLGYSNVGLFFINFYQNIHESISTENRNFFYSFLEICSNFRRFDSLNLNFNLNNKKIDSLFHLSMIIISLNIDETKMTETFLRNLKQDLISCFYLFYGKNGVSSSFDTVNNTEIKIDNQSSFNLQLKNILEKNKIFGKNIYENIKEISMLNEHNNLLNIFTVKNELNVEEILKNLKNIEIFENFSFENEEKVKKIIEKIYGNQMRNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP5</accession>
    <name>A0A4V6MVP5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0155p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000155">
        <property type="protein sequence ID" value="TBU20003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0155p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="90524" checksum="E40BF2AAD89EE769" modified="2019-07-31" version="1">MTGYIKNTGKNQVVSISNEEIDNSLAERQMRCQFEIEEEVAAKTVKKNGLKLRECVETNKSSQKDDFFRNNEFKIMIGLHKNDSGLINKNLPVARFLIKKIMSNEVLEDKRISNIQNISTDTLNGEARDEKSVLSVSEITKKYICPKASVEKIKYFKDKEIEKIPGDSEYHMAAKTTNTFSIVPYKVNKPEEIVGLKENVKPENKKSVDSGSIPLNRNENLQKEEEFVHRNVSGELEKGRENNNYTIQKFFIKEAKKINIKKEYNNWDKNHSDKQEMESDFKIRSNEAKIVPIEDEGIEGSQTEKIIQQNKERMGNLGCKIINELEETKKVLSIVHLNLDQNKESNECKKAFENFESENKNSNEGAFIDKILMINSSNIIALSKETDSKQCSDNNFDGDYSKKECLINVINEKTKLVDVQAELKEEYCIGTEKDTNKETEYEFDGSECKMNKNSCLEVENFHQPNNREIIPVDSFVKCEYTGNEKSESKNMIRRSEKQEILYKRVLKQIVSRENVYIPPYNKKRMLKKNILTFKKSDVMSVDTSLLDREDRIKIEEHYRKLLDRKIEQNESGVKKWFKSLFGCYRIKRNRIVNSIDNFIFKLIDFLIMSNISCTYGFIKEINNADVKEKIKKIEKQEYYKIEETNVLTNLGVVLFYIRERMNGIIPHHYRKILLNKKLKNDKKKLDSILDLMKFAIGHERIKMIEKIKNLIMNMKCNSEDPKLVGHLIDIFSKAIFPLKENANLKNDIHVLNVINFIFQSDLRSISLCTYYEATKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KW45</accession>
    <name>A0A4Q9KW45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1704p0010</name>
        <name evidence="2" type="ORF">CWI38_0621p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001704">
        <property type="protein sequence ID" value="TBT98550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000621">
        <property type="protein sequence ID" value="TBU12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KW45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1704p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0621p0020"/>
    <dbReference type="OrthoDB" id="2189043at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="736" mass="86283" checksum="F9C0A39237E78ECF" modified="2019-07-31" version="1">MEKLLNDLLIPSKKIDAENELEKLISTSNGQEELKTLLKENCTLAYVYIKNITSIWLTTNQQSKVVSVVLPLQDTLYCCVAIANDVNFNILCSYLEFLSKKEFLNKNFAFLLIEQLSIHPLKDIKFRRCLKALRAIFKKYEVLSRSDDLYSEIIRTVTLFKGAIFNLLIAKLSNDPDIVIPSLDIFYSLVFQDIHPFFEENSEKFFNTFFILFHSEIYQSRLCDIFKIFILKYADCINIETLLEVLLNNTHSYEYNQYNLILLLIKRRQIHVLRKNLQQIIYVISVGAIMSKKEMTVLYEDPISYIRSVQVLKQDSFRSVIFDICTCMTLFLKDEFIIPFLKSLNLEKDPLKQERDIFLCMVMSKYTGNLNNTIYSLLNGNTSDNSPLVVTCLRYLLLIENYEILDLSSVLKHLNSSFTYYFCILFLTKYLKNGKDRFINQENKIYLSNPGVINVVENKLENLDEEFSCEFLLQLYYVYKIPYFCTKNYLIFLIEKLEKNMLNVGSYTAYFNLFDLIGLFLIRGIFFYDEIQLFCQKILSKEVTELYSMTFCLLSILIRRSKKKLTYLVDLVCQKQLWLSKELIFSLSVLCVALYDDKMIDKNFIESLVKFLLETNSLYSAFFILYRTQIPNCLEWCDLARADIEYKTVLAYKIYKKNIITKNTFISILHEFVSQINNRPVDQHICGIVRNVLKDVVDIYDIGSTLKTDCLNIIGRCNENSDLPGVMICVVEEYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXT5</accession>
    <name>A0A4Q9KXT5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1231p0010</name>
        <name evidence="4" type="ORF">CWI38_0221p0010</name>
        <name evidence="3" type="ORF">CWI38_0820p0030</name>
        <name evidence="2" type="ORF">CWI38_1405p0010</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001231">
        <property type="protein sequence ID" value="TBT99743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001405">
        <property type="protein sequence ID" value="TBU11064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000820">
        <property type="protein sequence ID" value="TBU12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000221">
        <property type="protein sequence ID" value="TBU19103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1231p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0221p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0820p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1405p0010"/>
    <dbReference type="OrthoDB" id="2186488at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34775" checksum="9BED47AE5776183D" modified="2019-07-31" version="1">MSIDKSNKEKRKKSFLTKFIKNRICCNSQTSLDNFDESIFRSDKIFKNIYLQTKDSTIIGAWLISPIEINQNTKYAVLLHGNASNRRTFCENFEIENFIEMNYCVIVPDYREFGDSKGVFTVEGVIYDLERCIEYMYKTYNTDSVSIISYSLGTAVTLEFYKYFCTKYLESKENENNFYSIELPKIVLISPFSSTIKILQESRLWNFINKLFPKTEDKIREEFNFNSIDNIKCVDKRNVIIFHGSEDIIVPFSHGLELSLRNGCKIYRCNGDDHISIMLNPNVWNNINLFLREENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3W0</accession>
    <name>A0A4Q9L3W0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0538p0010</name>
        <name evidence="2" type="ORF">CWI38_0056p0050</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000538">
        <property type="protein sequence ID" value="TBU02168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000056">
        <property type="protein sequence ID" value="TBU20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3W0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0538p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0056p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="121" mass="14666" checksum="57488F8693D391B9" modified="2019-07-31" version="1">MNDGINNNFGNDFQNSTFYLKQRTKKPRGNNNHTTKQSKAKRNFIFNVRNYEEIVVIFHEMVKDTILFEKNALKMEYGMQQKIFPLLNKAKKLLYLYYKKYLYTIDRTSNIYLESLFSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L581</accession>
    <name>A0A4Q9L581_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0440p0010</name>
        <name evidence="5" type="ORF">CWI38_0128p0070</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000440">
        <property type="protein sequence ID" value="TBU02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L581"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L581"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0440p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0070"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="78" mass="9098" checksum="B77B4A120966BB17" modified="2019-07-31" version="1">MANNAKKRELIYDLQKYLNKNIFVKFIGGREIIGRLTSYDDSQNLVLEEPDKRNNEWFYNSRVVCLGNSIISISLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8Y9</accession>
    <name>A0A4Q9L8Y9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0160 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0172p0020</name>
        <name evidence="3" type="ORF">CWI38_0224p0060</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000172">
        <property type="protein sequence ID" value="TBU04187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8Y9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8Y9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0172p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0060"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="301" mass="34932" checksum="D57C7BAF8EDAD1C8" modified="2019-07-31" version="1">MLLATHNGLFHYDEVLATAILKKIYPDAKIMRTRNIKLLSTADIVYDVGDAYDASRHRYDHHQISFDERFSEKYTIKMSSCGLIFKHFHERLLEKYGLYLDSKYYNFMVDEIYASYFLYADGMDNGIDIFDNSIAVRTFSNVMYELAKLNSNYNDGFYEALSVVSKDLEQFLTFKIKYWLPSLEILVSEMEKQSGDIFFTKQNDFSTETAFVAEKILNKDFKFAVCEVESNNFRIYAFQVERYKFKSKIALRKEWRGLRGAELKNVCKIEGCVFVHATGFTGGNETLKGAIKMCNGSLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA26</accession>
    <name>A0A4Q9LA26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0209p0030</name>
        <name evidence="4" type="ORF">CWI37_0220p0020</name>
        <name evidence="6" type="ORF">CWI38_1999p0010</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000220">
        <property type="protein sequence ID" value="TBU03861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000209">
        <property type="protein sequence ID" value="TBU03928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001999">
        <property type="protein sequence ID" value="TBU10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA26"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LA26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0209p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0220p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1999p0010"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="327" mass="39415" checksum="357BB2C0723679CD" modified="2019-07-31" version="1">MLKILFYLLQIVCSKENAVILVLCRNSDLKGIKKTIINFEDTFNKQYNYPYVFLNDKVFTEEFKNGIKEATSSLVEFGQISSKDWNPPPWIDMEKVKYGIEKMKKTNVPYADSLSYRNMCRFFSGFFYRHPLVQKYDFYWRLEPGVTYYCYLDFDPFKFMREKNKLYGFVITMVDFLESIPTLWQTTSEYLHFYENYLPNIFIESFIFDENLNYNGCHFWSNFEIASFQMYRNTTYQTYFDWLDRSGGFYYERWGDAPVHSLAACLFLGRDKIHFFNNIGYKHGSFIHCPPQEIHSYRCTCKPEKSMSFKMDYSCLKNYLYEIKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEN6</accession>
    <name>A0A4Q9LEN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2577p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002577">
        <property type="protein sequence ID" value="TBU06437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2577p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="12985" checksum="A2E3564D5601EDCC" modified="2019-07-31" version="1" fragment="single">MEIKEGREGNLILPVIFKLATTNNSSKGFYTKNWCKKIEFERLKSLEKGKNILKNYSEKTSDYSRKINSGIVEIIRDISISKIIFDLRKSSYNLKILVTMAKGTVKLYFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG35</accession>
    <name>A0A4Q9LG35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2484p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002484">
        <property type="protein sequence ID" value="TBU06927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2484p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="38577" checksum="3B17AC15DA4CB004" modified="2019-07-31" version="1">MYIYNILFLFGSAFGANLLYKSQRAYNYRKMYYKNHERIEYYNRTDIQFSENPTFVRLYFENITAKIDETSGEPNINGDEPEKKNKKINERTGIFVDSPEFFHREKKMQAVVSLSKDDIEYTIIKNKCLTQEIFDIIPDIIKYLRGYLPEIYKYAYILKYNIKISFDKLYSQIKDIFETGLLNGDLKKYKETLVIYKIKYKSNDEFFPQIEYEKISKNGVLIIIAEEIPKIEYQIAYFLTIFKHIFTTEHNLYFFISFKYSIVDENSYARLPVRIRNKVLVNVNFYRSWIESLIYQHTVATLLKLVEYPSRDIIIDEYISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN36</accession>
    <name>A0A4Q9LN36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2156p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002156">
        <property type="protein sequence ID" value="TBU09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN36"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2156p0010"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19444" checksum="0EFA4A2981CF481F" modified="2019-07-31" version="1" fragment="single">MSKLQKKSKEIKTEEYNKLQNYVKDYKTVLFIKLDNYSTKSLHYFREVLKENAKICSFKKTAVLRVFKNVSEYFSNGIFLLFTNLEYSEIVEILLNLKDKNWIPNGVAATVNITLPKGILCHENKVEVNVLFHKKLKELGLPAVIKHDKLELNEDYDLIKENEVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN54</accession>
    <name>A0A4Q9LN54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2155p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002155">
        <property type="protein sequence ID" value="TBU09386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN54"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2155p0030"/>
    <dbReference type="OrthoDB" id="2194544at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17699" checksum="2762D4959BC73E15" modified="2019-07-31" version="1" fragment="single">MNKTNKDNFSKNNSLFYNNRGMVSRKTISLLETYFKLSCLPENYGILNSKPQRNNNDQINMVEFDLKIEGTEITMKEKIRKIKNIKKELSMEWIEHFEYMSETNGWGDKQMGLIAYKLIDDEDYKESLTKTSYLKLKKEILEIAYPLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP24</accession>
    <name>A0A4Q9LP24_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1983p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001983">
        <property type="protein sequence ID" value="TBU10149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1983p0020"/>
    <dbReference type="OrthoDB" id="74210at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="4">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15631" checksum="C137617D01744522" modified="2019-07-31" version="1">MIQQNPFVIQCKSCKTILGDSFTLLNYKNNTLIFSTLATTTNILPTNIVSNNTLDKDCTYNIIQCSLCNSFIGKKYIVVNFIYKEYLNRYCIEKDKIYSYQLGCEKPIDEIGVSELSEEISKLQKFCVYLFKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP28</accession>
    <name>A0A4Q9LP28_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2187p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002187">
        <property type="protein sequence ID" value="TBU09080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2187p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020567979" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="28468" checksum="E676F99BC4F5E593" modified="2019-07-31" version="1">MNLIFFIFLKNIFATMSFINYLPEDYTVNQITDLFISTNNLFFIFGNFNKDEEKRINGFKDGDYNSFNCFIAHILDKVYKNAHIYTTIDSLKNRYKENLLTENEIIASILDPKYNNIGVLILEKKNILYFLDLIKENKKRCIFINTNIKTVPPFYFKEDLISYTNNCNNQGIVSVAGKKYFCKCNMDYCGVGCEKKKNHILLNWCIFILTFFFVLNYFYRSNKKSEMVKSYLVVRKEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPV7</accession>
    <name>A0A4Q9LPV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1700p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001700">
        <property type="protein sequence ID" value="TBU10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1700p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8335" checksum="6D7881619047A91D" modified="2019-07-31" version="1">MVETEKLSKYDLLANDLGLIYRGLESGINAGESWESASIGVFKRVGMHEEPTPSLKQDRNDEYGVKEIKAKKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPX5</accession>
    <name>A0A4Q9LPX5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1684p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001684">
        <property type="protein sequence ID" value="TBU10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1684p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14624" checksum="596B3EABA51F39D6" modified="2019-07-31" version="1">MCDFSIDNSNVKTFSNLTNLKELNVHSIKFQNIYFSDLFCTSQKYNIKRLEFNKIKIFKRDLIFIANLEHIKELKFLICDIYQETYQNIKMLFITKFYIELRYYGGDENISEEFIQSLKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ08</accession>
    <name>A0A4Q9LQ08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2132p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002132">
        <property type="protein sequence ID" value="TBU09631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2132p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17070" checksum="0DAF8346EBEFE47B" modified="2019-07-31" version="1">MKENSKLNTAGNNEVVKTLENEYAEIIVEPKIITDITLIEVRIYSQDSLRIFETREPGKHDQLTNQSGLIYKFSVKVIPYVMTWDSIMPLCHKTYIKSLQIPMNVEPYIQSIVLKKTVEIISFDQRRELESGFNVEESCDRASLGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ97</accession>
    <name>A0A4Q9LQ97_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1700p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001700">
        <property type="protein sequence ID" value="TBU10524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1700p0020"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020891351" description="Leucine-rich repeat-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="82680" checksum="303E8D67B1CAE4CB" modified="2019-07-31" version="1" fragment="single">MKLFLLCFGLFRSDPCVYVSVRTKNLRKAIYFHENKCFATIVGLFDSNDNFLLYYDERNKEHSKSILKNYHFNEIKYEDLCVLRFNIPLFLKNISKVLNKHLRLETRIQPFYLEKITTCDNFYIFSLFLSKENALEIVSCKNTLIDIFKLLDFFLIEDTIPNIFFYINFVKNLISNQIYVPNKFTIQKSWTINNIRKHLQIFLTVLLSIDDINNIIRKSNNDCNMVNEFLQRKLKEIFVENDSLFIDEHVFDLILKKIGNIAFIKFLRFNIFFLEIKKITILAEKLDLKRSGLFNNISDTFISEELVLEGSDFYKVIPYIIDGRGIDKIKILKIIGTEITKGVIFSLNKLKNICSMTIISSELRANILVFNKGLETNLKYLDLSRSKLRKNDIQNFADMTELNTIIFNDSFHENNTFAGLKHSRFKNKLKWLEIKNSSLSSEDFNTILLFQNLENLNLSGTIINFEREYKFRASNFNRLQYIYLVGIPLNDIILGVLNSIKSAKKLNISTTHIESDTFPENLYKNSNLTLSSLNAGYNKISYQELQRITELQSLYELNLIKTTLNDSDLEVFRNSKLNETLRILVLSRTNIKGEGMLSFTNYNYLEVLDISFCDIRNLYFLKTNYFHLNLMKLNLSNNSLGNFNLSILGEAKKLKFLDLSLNNIKGGSLSILKNTLLASTLKVLRYIRNELNYMDIQTLETFRSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ3</accession>
    <name>A0A4Q9LQJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1636p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001636">
        <property type="protein sequence ID" value="TBU10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1636p0010"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="305" mass="35953" checksum="3D592147CB6EF8E3" modified="2019-07-31" version="1" fragment="single">RPGCKERLYLSRKELGRDLNSVELRSKHMLLLFLDRLEKSKEISTRRAAILKVKNNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLYSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGMCQYCGKSGKTVDHLATRFEKMLGHDYTRRHNEVVRFLHLLLLSRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRVKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMAWDGIVTKYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT4</accession>
    <name>A0A4Q9LQT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1769p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001769">
        <property type="protein sequence ID" value="TBU10426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1769p0010"/>
    <dbReference type="OrthoDB" id="2201363at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="24446" checksum="D4B9957D71004DC3" modified="2019-07-31" version="1" fragment="single">MVKKWRFNYLLYPIIIIFISLMSYEWIQTYKYSNRLHEYKNLFENNKYLISHIEEDTEDFFKSQKTASLKKINFIQMAICIFLMKFLFVLSFLNKSLRKKVENFNEKYKLFRCSFQSFTSEDLNIILKYSIVNTFINIFLEILFKMQSNKINFLLLILHIIFNILGQYVLLITLNAIIVKFGKKVFIFALIILVLLISPIHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQW2</accession>
    <name>A0A4Q9LQW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1747p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001747">
        <property type="protein sequence ID" value="TBU10456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1747p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="16808" checksum="464882A03D7934E0" modified="2019-07-31" version="1" fragment="single">MCKSCRKTPNNFYPRSNNDTYNSVQGSILRSRYDGNEVLYGANIYDTLYQATSSMSNSETENIYYPVITNPTALHSQPQTLYFNPQAPGTLFTSGLREYQDNFYNNRQLNQTQGDFVINPCDSHSRQLNTSNFDSDIASSHDSISRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR83</accession>
    <name>A0A4Q9LR83_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_1419p0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001419">
        <property type="protein sequence ID" value="TBU11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR83"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1419p0010"/>
    <dbReference type="OrthoDB" id="3240828at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="15">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="244"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="430" mass="46093" checksum="CF40794021AFA759" modified="2019-07-31" version="1" fragment="single">GIKGIKKAFLLNYKEEWVLQTEGSNLWEVLYHKWVKGFKCYSNCIIEVVEVLGIEGGRECVLRELKGVIESDGSYVNYRHLSLLCDVMTLRGVLSGITRHGVNRGDNGALIRCSFEETVEILLEAALRAENSVCRGVTDNIMVGQMIPLGTGNMDLLVDLECLKEAIPLIKGVFDFEKVENEYLDVKTPEIMSPVSEVSGSPVGGCWSPVGLMSGGSYYNPGSPLCGTASPSYRSGFVSSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSRAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPKSAFTPNIPVLTPGSVMPSPALNTFTPVVPDLLPGNEGTYSPDRGGVEDECYSPLNTRKSNKKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH4</accession>
    <name>A0A4Q9LRH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2065p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002065">
        <property type="protein sequence ID" value="TBU10050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2065p0010"/>
    <dbReference type="OrthoDB" id="2191713at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="33879" checksum="67158E823296F4A4" modified="2019-07-31" version="1" fragment="single">KKNIKKYRNSEKSDLNYKIEISDEKYMKENRLNFYDKNSYEKSNNSYETIIKSYDKMSLCDGCNNIKKQDYYFYLLTSYCVCSLRNLIEERNLVYEQKSLKEIVDSKDKIEFNLTKYDINGIFKGIIRGVLFLHKNNVIHRDIKPENIFFIEKEFYVPKIGDFGSCKIFTKSENSSDDDILMTEGIGTAWYCAPESTNSFYSEKIDIYSLGLIYLEMIYPFITSMERAIIFNYIRENGKLPNWLKNDFKKESIIIEKCIKKNPIERISALELFSLVLELTETNKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ7</accession>
    <name>A0A4Q9LRJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative S4-like small nucleolar ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_2090p0010</name>
        <name evidence="11" type="ORF">CWI38_1351p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002090">
        <property type="protein sequence ID" value="TBT97757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001351">
        <property type="protein sequence ID" value="TBU11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2090p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1351p0020"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="106"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT97757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="178" mass="21153" checksum="E4D8CE31BDCB7F18" modified="2019-07-31" version="1">MRKLKYHEQRLLKKVNFLQWKSTNTTREHILSTKYYLQDREDYNRYNKIVGNIRKLTNSLIRLKETDETRQYLGKLLISRLFSIGLIQNKKLIDCNKIKVSNFCERRLSTLMVRNKMVTSVKDASKFIEHGHVKLGSKIVKDSGILVSKIMDNFISWSESSKIKKSILELENKYDEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ3</accession>
    <name>A0A4Q9LRQ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1316p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001316">
        <property type="protein sequence ID" value="TBU11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1316p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="25162" checksum="55BBF1BA68635B65" modified="2019-07-31" version="1" fragment="single">VYLTIKSKKPMYIPNSNHWMINLNNNIYLKSIHIELEAFDKLPVIRNACNAKLHYIKLANCNLPGKSIILSFSSPYMLKNIKIFNYFGNFLSKNDLFYLSFMTKCKSLELSFCKLENCTLYDMFAADKLYIIEELYILDIILGKYDFLAIQKLKYLKYIGISLFRDSLSFIYYFKRMYFKRLRSFGTLKPAISLQERNYLISEFGSALDIYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU7</accession>
    <name>A0A4Q9LRU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1894p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001894">
        <property type="protein sequence ID" value="TBU10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1894p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1483"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1527" mass="171862" checksum="5B4F9B61ED7CEB41" modified="2019-07-31" version="1" fragment="single">KKLKYKLSSLSISLNNKLPSIILLDEINLTPSSVIEGVNSLLDYRREISVEGFKICNYNSFIFCSCNYEGEGRKSMPRSFIDRFVVIDMESYTEEDISKIMGCYNTSDINYSRGYNEGVNDSSSVGVNDSSSVGVNDSRSSVGVNDSSSVGVNDSSSVGVNDSRSSVGVNDSSSVGVNDSSSVGVNDSSSNRCVDNTLLNNSTFNNTLLTTKPSNNTPLPTTPSNNTPLHTTNINNTPITPSNNNTPPFNIMSLRTLYNLSLRDCLKIKLLNHNYFSINNPKYFIRNNTLYIGSAILPLNLYTNTYTLLHNQLNSLETIINCYNRRIPVILLGCSRYSVIRFISYVSKHKVSYIYCYKGTDTNDLLGTYGFSKLEGDNHSDYMGVNESIGKVEGDNEKDSDYKGVNEKDIYYKGVNKSTSNYHPVSNTTDKQHPFNNTTDKQHPFNKSISNYHPVSNTTHKQHPFGDTTHKQHPFNNTTNKQHPFNNNPNSTSFTWSDSSLVTSIINGNITVINRVDLVDKGIFDRLCSLFEFNRSLYITERGFININKDTWLVSIVDDLKGVSTAMKDRCVIVELKGVTDCIDVWKMHSSVKSSNKGGDKGYVGDKGVLNISDRNNTPLDIDSNDNTPLDIDSNKNNTPLDIDSNKNNTPLSNSTSNTVNNTPLINYSSSHFYNTPLINYNSDNTPLPLSLPLYDVPFPHILDLLSNNTSYINTPLWFNNTLIEEEIKGYSFPYKVKGFNYNNIGNIPLLTVELYKILYYIPIGVNDIEKLDILINNRGSDNDMLGSDMLDSGLEGVNNKNMIEGVNNTIDSYHPFSNSNSKQQGVNNSINDYHPFSNSTSKQQGVNETNDSYHPVSNGTSKQQGVNKSIDGYHPFNNNLYTHNPVNDITLFKRSVIFLSNSVLSVCKGYSVLELKINFIKKFIGCSVKEYKKLKGIYNKLKGVENFKMYKCSSVDIIGGDIGRDILGGVNNSTNEQQGVNNSGNTYHPVNDSTNEQQGFNNSANTYHPFNHSTNTYHPFSNSNNTQHPFNKNTNTQHPFNNTPYTQHPFNNNTNTYHPFNNSTNTYHPFNHTPTLLHTTNTIPSCLTFIINIILTYNIDPLNIIRNNLINNYNDMINKYKNILYNEFIKGYKYGESNEYTFYCKEFIVIYKEYIKRIEDIEKRIESRNIKGVIEEYKRVRGVSDKDRGVSDKDKYRGVSDKDKYRGVSDKDKYRGVSDKDKYRGVSAGTYNYNPVNNLSNKQQGVTDSTNNYNPVNLNTSKQQGVTDSTNNYNPVNLNTIKQQGVNNTTMNYNPVNNFNIIDFSDWLDSYYTGLFNDIVLLGMLFKKEVLIEVNDIHRLLDYCYISSKVKGVSDKDKVKGVSDKDKCLNVTTDVQQGVNNCTNEQHPLDISTTKQHPFNNTNIDIKSLIDTLIFNTPYSYTTSVISKAIYLLYYNRGVNIEEIVLECIKGDKYIEVCDKGCNRYSKGRCVDNTPLSNSNIYNNNTGTTGTENNTSISNNNTPLSNSNIYNNTGTTGTENNTSISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS07</accession>
    <name>A0A4Q9LS07_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1259p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001259">
        <property type="protein sequence ID" value="TBU11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1259p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18745" checksum="07A416A0405821DE" modified="2019-07-31" version="1" fragment="single">NYINLKKLKLHNCNLSCGFFKINPFKEILKSIEYLYISKNSLNLNDINIIFSLRNLKCLDISNCTFKDFNINSIILRLIIYSPNDRNYSDQNFSSKDKLLYFYHFEELKPIIILDLNKHNGINSKIFDLFTSKGIIQNKYYKIFSNNIEIIVELEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA3</accession>
    <name>A0A4Q9LSA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1222p0020</name>
        <name evidence="2" type="ORF">CWI38_1423p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001423">
        <property type="protein sequence ID" value="TBU11032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001222">
        <property type="protein sequence ID" value="TBU11409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1222p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1423p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="13937" checksum="6A01C3F57B6C6934" modified="2019-07-31" version="1">MDKNLTALRNFLVEFSNSYADKKFGASEESNLHESVKFLRNKILTELPRNKDISKIIGDCIQVFLDNFDDSEDAEGSGANVSLNAHGSSSISSNTDDSDEIVKKILYELVSEGILCITRFLMCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA4</accession>
    <name>A0A4Q9LSA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1257p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001257">
        <property type="protein sequence ID" value="TBU11344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1257p0010"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="966" mass="112891" checksum="D600C264FC8F9E89" modified="2019-07-31" version="1" fragment="single">FYPLLDHDYTISFQNILDCRKKINNITETIKTLVEKILANRKYEIGFMCYLMKIFRLKAPFIFHARNRPMIYCKPLFLLFPLWIEDTIQKELTLAKHLFNISLILNVTKAIMKYNYECLKPFFDKKLRESMQVGFSYHFCCNKCLMYNHFNLIIEFLGDIFTMLGEETYQKVLKYVSGAGFLSTNCDNVFTKNTSLEIPVILFDVFILLSKENFEFLHSIICDYEVLKESLENKDLKFVSYIKKTLNEESYLQNENCRKLYYNLVSIYERVFLGIPYRGSEYRLIPFNTKCVTKVVQLEVERRVLLAENQLGALALLNIALNKEYRNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDRILKFIKKIYRGILQGDSLSPLLFVLCMDPLSRNPNEKNTKVTVQTDAEINSTNHILFIDDLKLLAKDSSSLSAMTGEAKEFLEVIGLEINKEKSAQMNRVCVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERFCHTRLIAENLFSAINQHAISLINYHIGLDDVVRAELVKNKIHLRPGCKECLYLSRTELGRGLHSVELRCEHMLLELLDCLEKVENNNKTHLSLIKNFLKIKYRLEEEFTKKKLEEAQLANLYNEIERRKLHANLYNARKNELVCVSDSSRWLKRVNIRLRDEAVFCYIQDRNIFEPDCVCQHSGNCHSVQEIPDNEYTEIRLKRKTLKYDLLAIKLGLIYQCSVEIIPYVMTWDGIVTKYHKSTLTDCKYLIVRVEIILFDRRRRLEPGSKVDRANDENDDKEIKTKNNTPPISKRGTGHKHKSRVGFRRRDGCSKRKTNLPLLSNFSISNFAEQPLSRYNTNDTALGSYNHQVVSEAINSCQESPSNNHAGIITPEQDHMQNHSASIHTYMVLNKDKEVVFETKNHAIFKIIGSLCRKDVIRRLEYFYPLIEGEYTISIENILHYRKRINDISDAIKSHVEKLSNIRNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG8</accession>
    <name>A0A4Q9LSG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1623p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001623">
        <property type="protein sequence ID" value="TBU10661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1623p0020"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138159" checksum="35159730A6F440DC" modified="2019-07-31" version="1">MNNNIKEILYKLCGIESTNDSTNDNMYDTGRDIDNRDIDSKNIDNRDIDNRDIDSRDIDSKDIDSKDIDNTINTLISNLHYIMLKVSTNRFITNPLTSILYSVIEEVIDIYLKGISSIIKGEYGLGGVTYCRDMLEGVSNNEYRLEGVTYCRDMLEGVNNKEYGVEGVNDNEYRLEGVNDNDLRGVNKEYRLGGVNDKEYRLEGVSNKEYGGVNKEYRLGGVSNKEYNYRGVNNTTDLRGVSNTNDLKGVSNTTDLKGVNNVIKEDIFEEDVISIIGCYYSVMYEIRVLIDSELDIKGIRDRGEYYLEGYESNKYSMGMGMCNSSNNPYNYSSNYNYSSNNYTSHNYNNYNPYNYNPYNYNNINPYNYNTYTPITSPLNTISPFTLCSAFYSTLLSRISLNIKEEIKEWLLYGKCYTLIRERNSEYGYEECWYNGKYKVISIPYFLEDKWSDIYICGVLVNMIREICSYDYRDYKDYGMWGYRDYSSSVSNSVSSSVSSGVSNSVGSTVSNTVNSDPYTSYNPYTNPNPNTCINNTNPNPNICINNTNPNPNPNTCINNTNPNPNTCINNTNPNPNPNTYINNTNPNPNPNTCINNTTTLSGVKYRIYNNYLDTYTLSTYNILLKQEINNLILKEVLYDLNIIRSIILLMDTSYLTDTFEGVNVKELFCNGNGNGYEGVSIVERINSNINKRYSSRIDRRDVGGVSNSSSNYKGISDKDMLEGVNNSSSNYRGVSDSSSNYRGVNNSSSNYKGVNNSSSNYKGVNNSSSNYKGVNNSSSNYRGVSDSSSNYRGVNNSSSNYKGINNSSSNYKGINNSSSNYKGVSDSSSNYKGVNNSSSNYKGINNSSSNYKGVSNSIDDYRGISNNTNNPYTTYTNNPYNNISNPNPYTTHYTNPYTTLPNPNLSNNNPYTTPYTTITVTLSDIGVLERVGKILGIKRDWLDIGHLNKIIIKYECKGVLGMFISKKIKSEFELIYGFMVLVYGVMYSLRRIDNCLVGSVLGDVVEYMWCWMCYCVMEKYGRVVSGGGIGSGGGGSSGGGSSGGGSSGIGGGSSGSDGIGSGEGNSSKDNKDNSSNNEGSNINTKGNKDNTKGNSSNTNNTNDIRDNTKDNIRDNIRDNIRDTNDGVLGLEERLNGFCRGCLQGFFMLDSCIFVEVCCLLEMCCIYIKSGGVICMEEVIRVLKRMKVLFDSRCGFDFMCYVLEKIVYDFMCYVLENIVYCSEVKGVLFDSSIVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX1</accession>
    <name>A0A4Q9LSX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0711p0010</name>
        <name evidence="2" type="ORF">CWI38_1523p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000711">
        <property type="protein sequence ID" value="TBU01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001523">
        <property type="protein sequence ID" value="TBU10831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0711p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1523p0010"/>
    <dbReference type="OrthoDB" id="2186204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="203" mass="23277" checksum="5390DB89C8B0BB91" modified="2019-07-31" version="1">MFLFISWVSCGLTQIFLNRLNKFSEYDPGMLLVNVDMPDYALKIFDFNILTSKELPVAMAKLKEEDLPYMILHSYYEGNSKNFWLEMDNQYGIKISLSGNLLQASRFDIGGKSKLIAAKVLGTKNVLLMHNNQCLTVDAEQSKYREGYPIRLKKCKRDEPKQLFRFVSALKGACVLNMPVCPGLEILTDVERVIEHRISHFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX6</accession>
    <name>A0A4Q9LSX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1616p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001616">
        <property type="protein sequence ID" value="TBU10675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1616p0010"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8240" checksum="FC5A2D99820B2296" modified="2019-07-31" version="1" fragment="single">NCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHISKGKLRREGRLLEKYVCSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX7</accession>
    <name>A0A4Q9LSX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative M48 peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1075p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001075">
        <property type="protein sequence ID" value="TBU11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1075p0030"/>
    <dbReference type="OrthoDB" id="2201363at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="222"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="414" mass="49279" checksum="6CB9CB600BBEFDC4" modified="2019-07-31" version="1">MVKKWRFNYLLYPIIIIFISLMSYEWIQTYKYSNRLHEYKNLFENNKYLISHIEEDTEDFFKSQKTASLKKINFIQMAICIFLMKFLFVLSFLNKSLRKKVENFNEKYKLFRCSFQSFTSEDLNIILKYSIVNTFINIFLEILFKMQSNKINFLLLILHIIFNILGQYVLLITLNAIIVKFGKKVFIFALIILVLLISPIHINFFENTQIFEFINIDIHLLDKKIQNLIVSMGMETNIYKEVNPGETSNAFTILGFTSCKIYLLGRRILENKYISGTIAHELGHIKIGLKYRFLDWFCSRLLKGIMYLFIYFHLTTKIKSEKTSKMIIFVILVMIYNNFFKYSFVFLSVLIQQLEEFKADSFAHSEGFGISLIRVLCMINSSNWPLYNSKIFSMFFMSHPTLFERIENIERTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT08</accession>
    <name>A0A4Q9LT08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp90-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1062p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001062">
        <property type="protein sequence ID" value="TBU11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT08"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1062p0010"/>
    <dbReference type="OrthoDB" id="2196062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="818" mass="93063" checksum="06CD107871A2985D" modified="2019-07-31" version="1">MNPQKNTNTFLKHLKTTFITLIYLHLSIQTQHEFTLDTNLFENISSLLLQNQNSFIKELISNSIDANKKLVSETGIGDADINKHILITLNKKENIFSIRDRGIGMSYEELTNYVGKVGASGTRANKKEDSDFIGQFGVGLYSTLSVADGVEIVSRRYNSDQGYKFTFQKGSTKYTLDPVTSPIGTTVTVKISPKHQDKITQDTVTKWVKENLLRDPSSARFKVQMKVIDKEGKVVIRETDTSKQTEEKGEEKGEIDIEDKGEKEEIESTNESSNQDNDNDSDGVYDLEMTPWSYSKDLEELKIIFKKCFDSSSSTLLNAFNVKFSISQTNSEDVIVPVNFEALVFMPEISDMRMFGMENKGAVRVYVSGSMVHDPRLKSVPELLAPMYIILRSRDAQLTSSREEFLCSENTIKSIYSNLQTKVVDTIKNMSGKVLESYNTHIKSGLLNAKKENNEKLVNKLAIILPFETVDGLVTLGKFNEGVTGDKIYYTSIPISDYKMRGGLKHPLFDGIEIPFFFLNGLNDEQVIQAVVKFDNKELCDIVSYGVEKTKVKYDKEGKEDEKEEKSSGIDFIDFARKVLKSDCSSVVVSQRLKECPFCVKMESRRMSAGMKSVLGVNTIQKSVFRQMFEVKPIFEVNMEHEEVKRLDELSRVDEDRAGVLLKSYFLGTSVLCGVDVYDKVGSYLGLVNNGRVGLGLEMVKDEGMVETGAKITVGEDKDQKGYGFKEEEDEMDREDKDKDNEIEEKDREEEYKEDKEYKEYKEDSMDREEEEYKEEIEEGDEDSISKEVIQEDKKEDEKEEVKDVPKAVVEEELKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT22</accession>
    <name>A0A4Q9LT22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1584p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001584">
        <property type="protein sequence ID" value="TBU10725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1584p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="20152" checksum="F3DCD0F60827954E" modified="2019-07-31" version="1">MGSNRNSEILDLQNKEEGSIFEINGSNCIENVNKYKEPYIIDIQSGILVKPIDLLEIKTPYFLKNINENIFPKENESQKETSMILEIENHQSDKKEEIAKDNPYKGHSQGANVNITQYYVRQSTNCYSSFIYWFILFYIFVIAFLMFYLFYSLIQDFSYSPLVYNDYVDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT77</accession>
    <name>A0A4Q9LT77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1030p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001030">
        <property type="protein sequence ID" value="TBU11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1030p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="115" mass="13111" checksum="4963197E2E38AE75" modified="2019-07-31" version="1">MGVKYKIVINSVKNMSINLRGSVKYESINLRGVKDFKYKSINLRGVKYKSINLRGVKGVNYKSINKGILTIRVLIKRVLNIDVVIKGVLSIRVLINRVLNIRSNKQKGVNQVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA4</accession>
    <name>A0A4Q9LTA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1016p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001016">
        <property type="protein sequence ID" value="TBU11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1016p0030"/>
    <dbReference type="OrthoDB" id="2190823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="984" mass="112365" checksum="5F7F5B6FD826F2BB" modified="2019-07-31" version="1" fragment="single">MKISNTSSIIAHIDNKNNLQLYNLDTQISHLYTHTYKSPPTCVHTVPTHIYIGTLSGDIYLHDFITQTDFFICKFFSSVRCIAIQDSLLYAGDESGTIKGILISTVDRMDGMDRSDGMDRLDGMDRMDRLDRSDRSDVLDSSLYTNTQNTTQNTPYAFKHLISYKQSSPILHISTSPTTLYVLEQKGRLTLLPSKISFDIFSNFMIFHKYLFIIENNFLYCKTKQAFAVIFTYKKRIKQIKFNKNGTLMFLQVGNSIKVYDFNNKILIKEIDTTKELDSNILNSKDGCDNIKFNNSDNTICDNTICDNTIICDNSNNIDNNNIDTNTIDTTDNNIDNNTTHITNNTYNSIDTIDTIDTIDNYTTYNLINFIFDEDRNRLLIFKDKIYFYKINNLEGEMTNIKFKESKMEIKKVFVEQKEEKSKKKRYVEDEYGESGEDVISSSSNKGDISNKSKGDISSKSNISTKSNISTKSNNKHTNNKHTNTNIKHTNTNIKHTNNNKFIQDECEDSSYNSCDSTDENNKFTIKNKSRITDISEKYKGDHLNLFENECSSDIRSLVEYNSEIDEREEREDIEGRDIEHPSYISPNTYDKLRLPITKNGISLIFYNEVGYVIQIKEDKYIDCGDGVDYGVDGVDGGKEIEEDEVYNKSVYNNSNNKSTNKSTNKSTNKSTNKSTYNVITEVIYHNSKRPSRKFKEKINKIDFTENRIVISNENILKVFMNGDSSRGDSRGYGGVGDNRDYNRDDIISNPYTNTNTSTNTYTNTNTYTNTYTNTYTNTYTNNISCNDWSVSTLGVITEITVSNRFIGIVSKLEGVNYIISIYMLKGKKIIEIGLVNIKGVNSYEYKLGVIYNTNILKVLDIRTLKSKNINLLYNIERCYFSEEGYIFVWGNGFLYKVVDKLCVLLQRIEGVVLCVSGGCCIVYGKGMCVYPLEVEYIRIVDERLAGNEENILKEFKNIIEGVGVGVGCDVGVGCDIKDIKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF9</accession>
    <name>A0A4Q9LTF9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acetate--CoA ligase</fullName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1520p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001520">
        <property type="protein sequence ID" value="TBU10840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1520p0020"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="115"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="747"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="854"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="925" mass="101689" checksum="66752F04FEEB528C" modified="2019-07-31" version="1" fragment="single">KGVNDKDTSYKGVSDKDSNMKGVNDKDSNIKGVNDKDTSYKGVNDKDTSYKGVNDKDSNIKGVNDKDSNIKGVNDKDTSYKGVNDKDTSYKGVSDRDSNIKGVNDKDSNTTTKTTNNTSNKYALICTDNDNRVTTYTYKQLYDNIIQISNYIDSLSLPSNTSITVYMPMSQLPVFVTLACARLGITHNVVFGGYSAESLALRISDSNSSLLVSIDKTRRGTHSIDFLKNIRVALDILKKEGNTTLKHVLIFDSGEGGIEGDVIEGCNRVDGIKDISNRDISNKDISNKDISNRDISNRDSIKDISNKDISNKDISNTKDTNNLTPNTNPTTNNTNPTTNNTNPTTNNHISVAYWSSIPKNNKHIPCVPVSSEHPLFYLYTSGSTGKPKGIIHSTGGYLLYVLLTTKYCFNVNKSDIFMCTADIGWITGHSYAMYGPLLLGCTTVLYNGLPIYPSEYRMFNIIEKYKVTHFYTAPTVIRILQRVFNNGGSVSGVEGSKGVSDKLEGKDVLKGVCSNDSVIGSVSTSESSIGSISSVNISANEQQGVNTNTFKQDPVTNSTNDYHPVNTNTNEQHPVTNTQPSCIDDFDLSSLRVLGTVGEPINTNAYKWFSRYFGRDKLPIIDTYWQTEAGGVMISPIVNVSTNIPECAGIPFLGMEPMIIKSNSSKEKIVQAGIGEMGALVFKGGWPGIARGIVKDKSRFEESYFNKYKGYYYTGDEGYKDSEGNFWIRGRVDDVLNVSGHRLSTAEIESAACSDKCISEAAVVSVNDSITGQAIVMFVVRRSKNEEGGNKEGVNKNKEGVNKNKEGVNKNKEGGNKEGVNKNKEGVNKNMEGGNKNMEDKNKEEYKDLDEEDVVKGLKQTLRNRIGPIIHVKRVIFCEELPKTRTGKIMRRVLRSLLTGESVGDVSTCSDKDVIDKIRCVVNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU45</accession>
    <name>A0A4Q9LU45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1070p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001070">
        <property type="protein sequence ID" value="TBU11716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1070p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="50888" checksum="92CCB0DE9498DBF5" modified="2019-07-31" version="1">MLITTFCTKNPTKTSKCNIKNLFNIINKKIYELYTEKTKKYDEICSHEFLFLESSNYLLKESSDEIIEFLLAKKSKKIHIIVSLINNTEMENGTVYYHSLTISYRYFMIFRFRNNRRPVSNANILNRNYSTNSKPAEKEYYLQKHSSKFIFWHLNIFKRILTKIILKDKQFSFVPIFSDLAFLKATDHDFIFSMLFKQTYKYNNDYFLLINDLKINKHYEMNKKNNKKILEYAFTSAKFELIKNISFERKDRVTQSSKGCLFKNVCNKLVVKEICLCGYKKYLNVNEVYISSLREDKKQDSINKGILNNFGYISSDIDIFTSVTEDKDNTLNASNKSKKPKKNKKILQETCYLTIFYRETSTEYIINFLYNVLNYDLINIYITRSIPGFSCDMPLKEKISFVLVLVKELERFDFKLKYWNNFKSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB9</accession>
    <name>A0A4Q9LUB9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1323p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001323">
        <property type="protein sequence ID" value="TBU11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1323p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="9382" checksum="17A3A252DF66E73E" modified="2019-07-31" version="1">MKTVETISFDRRRGLESGLNAEESWERASTGIIKKSENMKNQILQCSKHLKTKNITSLFSKRGTPCEESAINIRKNKVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF0</accession>
    <name>A0A4Q9LUF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1310p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001310">
        <property type="protein sequence ID" value="TBU11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1310p0010"/>
    <dbReference type="OrthoDB" id="2194559at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="222" mass="25871" checksum="A1117E4B65B8120A" modified="2019-07-31" version="1" fragment="single">MNTIRIFIISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPAGFSKLDDAVRAVLVKNKIHIRPECKERFVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKLKYRLVEEVTKKILEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQRFNKSGKTVDYLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP1</accession>
    <name>A0A4Q9LUP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1277p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001277">
        <property type="protein sequence ID" value="TBU11300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1277p0020"/>
    <dbReference type="OrthoDB" id="2194154at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16172" checksum="B95DA97FFFDCD8C7" modified="2019-07-31" version="1" fragment="single">EIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVIKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR1</accession>
    <name>A0A4Q9LUR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TB2/DP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0920p0010</name>
        <name evidence="3" type="ORF">CWI38_0772p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000920">
        <property type="protein sequence ID" value="TBU00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000772">
        <property type="protein sequence ID" value="TBU12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0920p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0772p0020"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="192" mass="21529" checksum="43C7FDA97B289B36" modified="2019-07-31" version="1">MESLKKLAVKFPVLAQLESKTQGKMKQEYSVVVAISLVVIIILSTPIGGILGSLCAVLVPMKETLTLLKQVNPKKEEFRHAVIFWLFFSFLLFLDAYLAFLLAMIPLYTILRFIFLLWIGPCKFGGTAFLYENILAKIPEKFYSYDTPEDAIKSAAKVAKDAFNSTAKNGTSKIQEEGVKKVIRPEGDKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS8</accession>
    <name>A0A4Q9LUS8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1166p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001166">
        <property type="protein sequence ID" value="TBU11511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1166p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020577054" evidence="1">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="315" mass="36930" checksum="DA222FAC42BF26A5" modified="2019-07-31" version="1" fragment="single">MLILKIKLLFLLITYTSGSSFFQSFLENNLESKKQKQLLNEFHEFQESQLGKLLKDQYKDNKDFGFVMIYITDDISSLLELLRKRSYVEENSQNETLKKVSEWIERLNLVVLPFIFSLDKFEKFTSEYSPDISAQAIRCVTEKLNVIGFLHKFGTFVKECKNHIEMFGLLNVSFNDSLLNITLEKYINHDFHTVKSFQISLDHSDPRAFFVFILYKANIFDKNHVYDSFLKKIYPDTVLKQIIGDALAAEIKTVDGMKEFLPAYIPKIEEIKEKLNAIEKRLKNIESLGWVQSALVNLSLWYWKTLVSILIEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV09</accession>
    <name>A0A4Q9LV09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sphingomyelin-like synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0727p0040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000727">
        <property type="protein sequence ID" value="TBU12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV09"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0727p0040"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="30069" checksum="EEA953FC58CCFA46" modified="2019-07-31" version="1">MLKKILKRYNINSKNIFVLLSVVGFTIFTLYMMNLMSNVASFWSPNNKAYEPLPDLFFDLFGYKNVEKIVDTLMYMMLISTAIAILIRKDAILIFFRLATCISFSYLLRMTTVGITNLPDPNLDCFQVVEDTLTEASYRRCGDNIFSGHSIIILMCTFVWTKYDFFNNELYWLIMSVFVWIICITNLVCILFARYHYSVDILLAFYICSSVWLIYDLIWTKYLIKNAYIASLIKQEDRNNQLVNSLTEYEKETKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV91</accession>
    <name>A0A4Q9LV91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_2345p0020</name>
        <name evidence="6" type="ORF">CWI38_0701p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002345">
        <property type="protein sequence ID" value="TBT97333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000701">
        <property type="protein sequence ID" value="TBU12599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV91"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2345p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0701p0040"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT97333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="109" mass="12636" checksum="26F3CD9E9A102A9F" modified="2019-07-31" version="1">MLRHIQIESKEQYFDILKKNNTIGFVKMYATWCGPCNTMSKELERYSLPIPVNLYEIDIDKVSELAVEYKIRNIPALLVVTAEGKQIDLLLGYKDVNVFESLVTKHLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV99</accession>
    <name>A0A4Q9LV99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0697p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000697">
        <property type="protein sequence ID" value="TBU12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0697p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14306" checksum="7EB9B61CCFEC8D93" modified="2019-07-31" version="1">MIDKYFFTAFIEESLQKYTIKPLKDKKKYDIKLFCSSFLPKILSTKNISLKTNDKGTYIIITDVLPLYLEYKNNWSLIHSKMLKVRCLGRKVESVVNISEVFILKSKLICRYKNTILNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB3</accession>
    <name>A0A4Q9LVB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0852p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000852">
        <property type="protein sequence ID" value="TBU12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0852p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020188116" evidence="1">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="41307" checksum="76450BDEE6AA15B0" modified="2019-07-31" version="1">MIFSSKIVLKILIFVFLIEKANTPNNNCENEIFELKQLEPAGKYYLNMISYYITRLVLNGELNMNRGSELDYILNNVIKRYPRNVENHFVKFMNLEWNEKHQAYKSKKFVGENCFWKFLPVLIYKLKNTVLKSIIDKYKITSDYFSKEIENTPQWKSLDRNDFIDNKIKKVREKLSLFIRNSGNNPNNSSSELIYDDKFCRNLNNREYLFENQFLTENAEMNSENLELLYSFELNEMYEKNLLNDLFSKFKQNFYFKNILVDVFQEIGISSYVFTYDLSRKKKRKLQNSIAYIYTHDKYFQECFIIYLSNSLKPHLEKYVKAMFRTIEEFNLTNIFLMENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB5</accession>
    <name>A0A4Q9LVB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1150p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001150">
        <property type="protein sequence ID" value="TBU11540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1150p0010"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10191" checksum="3173BC6699525691" modified="2019-07-31" version="1">MNVNICKNRPKITFIKAGIKSQDSLQIVETEKPRRYDLLANELDLIYKYPNAEESWEERTISIKKVSTKEEGLNILKQKITHYFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX8</accession>
    <name>A0A4Q9LVX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0634p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000634">
        <property type="protein sequence ID" value="TBU12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0634p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020501518" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="23048" checksum="83A992C696C2BA40" modified="2019-07-31" version="1">MLFALCFFFYESLINCASGSDMLDKKEELIESRSSIDSLNDVGSTLDSAAFAHFNKYENSSLTNGEISNESTKTSLNANEAILSYIANTIFEKFKGHKPVSISSSDDSMSEVNPLASERSDLGNERYSFGENKRSQKPIISENLRDKEEVESSGTFDLLIMEENEAIANEWPTIKCKKYDCVVEIGEVLENESTIENLGAVTEKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE9</accession>
    <name>A0A4Q9LWE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0137p0020</name>
        <name evidence="4" type="ORF">CWI38_0566p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000137">
        <property type="protein sequence ID" value="TBU04422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000566">
        <property type="protein sequence ID" value="TBU12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0137p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0566p0020"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="356" mass="42107" checksum="E8CCDE9CE1BF3F6D" modified="2019-07-31" version="1">MLLEVIRKITVALLEYLLNSRLIAYLFHLFSKNFILRKIKIGKNLSISFIMDGNRRYAKKSNQNDIWAKQNGFKNMLCLMRYCSEVGFKEISFFALSLSNLQRDKNELEGIYKLIIENKNKLMDKKYEVRVVFHGRFDLVPIEVYNVFKEVMVMTKDNKKCIVNIFFAYSSTDVIKRNYEATRNNIFNDDILEVKKNVKRGSDFQSINIVEEGLKQRKNNSQTKFFKEKSFDDSKKENMKNKIKESKNKNIEVYCKNIYQQKRKISKDTVKNIEKSNKGGNGDNPEDIYTCLRFNDDRSTDIIVRTSGELRLSDFRLEDCAKGANIFFCKVFWPEFTVFHVFLICLKYKFENKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF6</accession>
    <name>A0A4Q9LWF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0563p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000563">
        <property type="protein sequence ID" value="TBU12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0563p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1065" mass="125640" checksum="6E12B4C441003FF8" modified="2019-07-31" version="1" fragment="single">MDNTSKENLNEVFWEDPIEWSSDSSKSTEKNEFSNLRTYEPTNNEREEEKKEKKDNCCKEEFVSTKEGNEGEQSKVEKKDNCCKKESVSTKEGNEGEEENERSEEEKNDSFEEEFVSNIEENSKEKDIETDNFEDGFVNSELENLPSEETKNIFIENQEKEFESENIKMENKNLKDEFSTDIEDNEESKFIEKYSTTDGLETTKEENIYKDENINEDESIYKEESIKEDGSINEDEELSTKYSTTDGLEIKEEDNNKEENLNLFDYKMKDEINKDLFNEIDDDLENLKKDKIEENDVNFKDKEREKQVICNKDMNIAKSIENNNIRDLFTFDSNDWNPEDLLQQENSSDNNLTKEKTESEDKNILEDKLEEEFERIVENEENILESEDRNISEDKLEDSSDVLNKEISKNILESKIQAFKEKEENSSELFNKEKNEENILETEIEEFKRKDETEENILETEIEEFKKKEDFDFKEYKKTEENTDLENNLIKNVSENIKEEELSNIYEKDNINIKFNTERVLSIENEQISNISQLDDGIESKNTCEVFTDEINESEFLESKKSSDIFLEYSEEKQYFENETEETNKNFIDKSYFQVNENIKEENVLEKQEFKNEIFEKVETLNESFDSDKKTEDPNLFGIKEKEITDYFTDSEDCNELIFFKEKNLKETTEYLTTEDAMNNEIIIEENKEIENLRIDEDAINNEIIFEENKEITECFTVDEKLNKEGNDELIFEKNEQKTEYFTTDDYTNKEGNNELIFEENKETTDSIEKEDLNNKIIVEEAKQITDYVTHENIFLDSFITPKEELKDLEISKSPQKNPEKIFDLPDDLWGDEENTDLKFIVKKVENISLETEKDEKKCTTQNITAYPHKDKDICITDTSNVFQEYEEQPISQNITAYSNEFKDICITDTSNVFSRPIKNFTSTKNIKEFNEETPLPSKKETLENKSLNNLSTTIFTDENKKIDFERKKSIFEKPEKEKYNLKTHEVGKPIYLPKQANILDSKEQITPLTTHEVVKPIHLPKKANILDSKEQITPLTTHEVVKPIHLPKKANILDSKEQITPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR7</accession>
    <name>A0A4Q9LWR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0633p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000633">
        <property type="protein sequence ID" value="TBU12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0633p0010"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20174" checksum="CF7F003357DF6209" modified="2019-07-31" version="1" fragment="single">ELQSVSENNLLVKNQIKNVNGEFSELDSVKLTRLQREVLELNMKKTKFISKPTHFLCNAFEIEDLNEFKSLELNANSFYCYLYLASKNLYSLDLLPIFENKREKLKLLYNYIHYKGGNSKSTDSVNSTGKKLSEKDVKTALKLLKINKKFDKKPNKLFERRLKLFIKKIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWV2</accession>
    <name>A0A4Q9LWV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0630p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000630">
        <property type="protein sequence ID" value="TBU12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWV2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0630p0030"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="9">
        <location>
            <begin position="286"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="512"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="648"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="12">
        <location>
            <begin position="722"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="868" mass="100558" checksum="AF08FE176C4A8CF7" modified="2019-07-31" version="1">MTLCETENKIYSLINDGIKNNYRSVFVVLGSNCNEVSIKLHHILSKTRIGIKPSVLWCYKREMTGKNYKKKKMANLSNQVKSGMVVEEDAFEVFNSSTNVDYILYGECDRVLGRTYDMCVLQDFDCITPNIMAKTVETVCGGGLIIFLLENIYKLEDAFEMKMDIHKKFGDLENEKMRFNKRLFCSLKKSKFTIFLNENMEVLNISKYKSKKNELIRKENIEMENKSKKCKESSSGSKKYKFMNGLITKDVFKENEKIEKTKEQRNLLVELEKLYSDRNNKTIISVTAARGRGKSALLGFSISDAIKNHFGVINVVAPALENVKTLFLFVENGLKELNFEKNKDYQIYFTKINNKKFVSKISITKYFKQVIEYVDPRIGLKLYPDLVVVDEAAAIPMSFLKPFLECNVVLMASTLNGYEGTGRSLSLKLFETLRKNSKSKDSYIFKEFILNESIRYSRNDPVERWLYDVLLLDAQPPKITFCPPPENCELAYVDRDILFSYHSASEIFLNEIVSLFVASHYKNSPNDLQLLADGPKQGIFVLLTPLDNKSVEGKENANCSILPKIICAIQVTLEGKIKNTQTVSKDGNLIPWTVYEHFIDTEFINKSGIRIVRIAVHPDFINMGYGSRALDLFCRFFSEQNSSENNFFIPKNTMKKSLLYSLKDILIPKIEWIGSSFGVTSHLLFFWKKLNFLQIYLKQTPSKITGEHSVIVIKDIHDNNTWIYDYYNIFISKFINLLSYNYKDLDPVLSLSLYYDKNLTKFKDENIKIKNYFSCFDIKRIEIYCKNRIDIKMIMDLLPIISFLYFKGKFTFNLDILQESLLLIVGLQRKDLCFASSIFKLDSSHINSIFLKIISLLFSEIFKMYQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX14</accession>
    <name>A0A4Q9LX14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ring finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0821p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000821">
        <property type="protein sequence ID" value="TBU12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX14"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0821p0010"/>
    <dbReference type="OrthoDB" id="2196293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF9">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="300" mass="35947" checksum="7AA82C3F58F04F78" modified="2019-07-31" version="1">MLREGFWLIKYIIWYLVNDNYGKLFSNIPGLEEIEVTVINCVFFGSNGEKCPIVYPKPRDMYLLHNWNIRNMTLPEKVNLDFFNTFYVPKAVIIDCKYWDLAYVEKLLEKFYCIKFLVILSYTKKGYGLKEILFDEQYSYLSESKHNIFFIDDHQSNIFRKFYGSQCAINNAYLKGYEMHSTVYKTIEKFILYLFYISLIFFVCISFIILGMWLRIRAKRDPIITSSELNSCPVRFYKDLVDKNMFDSCLICIDLFNDFSKCRILHCGHYFHKECVDPWLKFKSSRCPYCRKIIKKEPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX23</accession>
    <name>A0A4Q9LX23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0817p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000817">
        <property type="protein sequence ID" value="TBU12285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0817p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="550" mass="64500" checksum="F6A63C24BAFF84BF" modified="2019-07-31" version="1">MYFRKILLYDYYSLIIFLFLTCKSSNNSGHVNEIHRRVGDRAQRIRYDLQHARHNNLPSKRYIRRYNPTGSGSQSFSCSGYINRNMPFQESSSQVFETKSGPRSINPPLLFSTNAPHQYSQMQFVNATSNLNSIHSVSALPNSSFFPPGRFNSTQNTLHMASGSTYNHNTINNLCFPPPFINPLPQTLFLKKLYDVIIKVLKYPTLGKFSDISIFFTSEYFFEDILNRSCLIGYFRTLKNLVAIEKEIININSEKKKEFEQAFLINITKIDLEGANTNILFHVPMLITLKNFISKQLERNTSDKKYHVSIFFGLKLIESVIKKTHLAIYGTLNSPENIQLSFDPYRNNFIRTNSNIILEIIDWIFTLSFSFNETFKNAFVSIINMQKNKSLDVLNNPEGLFGIYDLSFLPDIFFLLEESEIKEIYEFNRLVLGYCNDDSRAENHGPIDLLRRNKFAIENERIIKMIGYYFIIFENFEIDFFKQRTSDNLVMNRYELLKEEFQEFKQKKMPLNPREILGLRKLFYATHFLFYDVIAILYNRNIYTTIIPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX53</accession>
    <name>A0A4Q9LX53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0459p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000459">
        <property type="protein sequence ID" value="TBU13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX53"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0459p0030"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="631" mass="72606" checksum="2C4380C490F99FD3" modified="2019-07-31" version="1">MNFEWRNVDIELRNKNKNMAGSHVKLIKNANGVVPKGSLCAIMGPSGSGKTTLIKALAGRVSSGARTKGEILADGHERSYRNWCKNIGYVDQDDCVYEQLSVLETITYAAKFRLKDKNVDICQKVEQLLNELDIYDISGTRMCSVSGGERKRVMIAVELVTQPKILFMDEPTSGLDAHTALNLIYLIKKLSKSHNMSVIFTIHQPSAEIFSIFDTLVLLSDSNTVYFGEAKSAEDHFAKYGLKKRDLSSFPEFLADVLKVKKKYTESHENQAIMSQMINDNEKSCNKQFGAIISTKNAFIIDLKPSFKDIIILLHRRYKVSLSRKKIIFSIFIFTFFFYIFCKFVSALLDSTAVKDIITAIFNQYTFYISNTDIKNSIQEVLSNIEEMKKVFSRPLAMNFLSFFFAYSMIASTGSFSQEYKMIMRELGVATFSITSYYLSVFLFEAFCYLPMLFCSALFVFFKFGYTYIKWEFYLFFFGGMFCYLPTILFFGSLTKRTKTIYVLISFLALTWILPPTIYTGLYFTAVKYDLNSLHAFIYIVSLFPPLHYNTMCVAVAYKLSRKGVKLFETFPRLKECTDALEKFFTSYLFDSVKIWQMFSFFIVTTSVYTLLSFLFLGIRLMPDMRFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL2</accession>
    <name>A0A4Q9LXL2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0403p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000403">
        <property type="protein sequence ID" value="TBU13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0403p0010"/>
    <dbReference type="OrthoDB" id="2195662at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="517" mass="59626" checksum="F9B7AC698A58D545" modified="2019-07-31" version="1">MNSETVDGKTYKNYFEAARAKGLTTDKNVWNETLNDAVTMKIPKNIRDLFAYIYLFTYVTDISKFMTNHKDNLIEDYCHFHRHPVEEFFELCVSYALNNISRILNTHGKRCRDFGLEDPLTSLLPLCATFDEEENFNYEETLNEEQRIAFEQIMTTLNNSNNEKSFFLDGLGGSGKTYLYKALYYTIKRRIAAKLLHKGRTYHSRFKVPLILNETSVCAFALQSIDRLLRDIQYKSRVSFGGKVIIKGGDYRQCLLVIPGAQASDVVQSSLKNCSLWNDFKILKLRNNMQAKDKPYKETLIEILSHMISKDIFGEVQFVNTIYKFSKKVILTHTNEEVDKINQSEKTYLSTDSLISDDTDDVTNYSIEFLNSLTPFGTPLHALYLQKGAIIMLLRNLNTESGFFNGTRLIVYYIFLQRIDLTSDAGLPFQLKRRQFPIRLAFAMIINKAQGQTLYKVGIFLPTPDFGHRQLYVAFSRVRSLNDVKVYIKDTAEQGKILPGSDKIFTKNVVYKAVFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY39</accession>
    <name>A0A4Q9LY39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0687p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000687">
        <property type="protein sequence ID" value="TBU12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0687p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="277" mass="31382" checksum="BF7C084E4A5323CF" modified="2019-07-31" version="1" fragment="single">MQFTSLLFFFSLDKCSRRLIVDRKKVEHVLNDFVSMIHIERKCLNLSPRNTNSHKVCIANKYISDLDEINDSKKISKEFYEATNLTFDEKFSKDSKISSKEYFCNFQSLIENDCLDIKSFMTNRPQIFKVFGGTNPNTLEWPHIAHTEQLKSFKRPPPPKKKHLKQQPSAQQTAGQETAEQPIAEQLSQGKPPIPPKPEHLKKKPSAQQTAGQETAERPIAEKLSQGKPPIPPKPKFEKKTLATPGEPINTPITTPGQPITTPDQPITTLDQPITTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB3</accession>
    <name>A0A4Q9LYB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0587p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000587">
        <property type="protein sequence ID" value="TBU12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0587p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="334" mass="40775" checksum="71760B2489126BFD" modified="2019-07-31" version="1">MEIELIKYLFDKENGIEYDKYIFEDIEISCLKFDIFPNLDIKNSTQEIFLCRHITTSDFEIFYRFIISYYFLYEKMTIESFYTILYFLEYLRVQYDNKLRKVLILIFLSLSQSTELENDVVDKIQLHFSKQKIFSHAYFKIISQEYFKEFKHENNFEPWIFIKEKNFVLFEKYESFYTANRKYLLLLKGNFFEKFSKKITRNVKRKNLFIILLNTFDLKYLDIHDLESKYLKICCFILDNLKKTLDEIVFYNICVRDKLIISLNTNQTFIHLKKIVFLKSKIKTKLKFSNNLNKIEEFIFNDSCIINKQNSISEYQILERLEDIKNIIINSQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG0</accession>
    <name>A0A4Q9LYG0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TEP-1 C-terminal beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0312p0060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000312">
        <property type="protein sequence ID" value="TBU15423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0312p0060"/>
    <dbReference type="OrthoDB" id="544788at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056828">
        <property type="entry name" value="Beta-prop_TEP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25048">
        <property type="entry name" value="Beta-prop_TEP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="TEP-1 C-terminal beta-propeller" evidence="7">
        <location>
            <begin position="512"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU15423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="614" mass="69353" checksum="920353C55D79F20E" modified="2019-07-31" version="1">MSQQVLIEFYDTQNNKIRDKLHVPLSITRKHLLSLLNQPTPSNLYLNDQEIRTTLQDVTDSQKICLEQILKIKILPSTDTLPIQTTHCSSSYSGHESPVLCIKYSTCGAYIYSGGGDCTLRVWHALTKTQVKVNKHHTHWVLCIDCSIYTVVSGDMSGTICTYTVTGDFIHTHQIHKNAITALILHHDRIYTSSRDKTVKISTLTGTILYSYTHTQPVTCIALNTYFFISGSTDKSLKIYTHHFKHLKTLTNHKNRINCIFLNNKFILTTSDDHTAHLYHIEGLENTNFEKLDNKLENNLDGNKEGVNDKEVEEGVINSTNKQHSDINEFGEQQGDIKESNTSTNKQQGVNNLSNNTTNKQHPLNNSIDKQQGVSNLSNNTTNKQHPLNNSIDKQQGVNNLSNNTTNKQHPLNNSIDKQQGVNNLSNNTTNKQHPLNNSIDKQQGVNNLSNNTTNKQHPLITIPSSFITLNHNSIITTASISPNNTIIATGSFDKKVKIWNTTGTLISEYLHLNSIYKVHCTNTSIISASKDGIIKIYSYYNKSIVNEFICKNEIYCFDIYNSQLVCGCKDKKGRVFRERSDRIRDTNTYHPVNNNTILIPITLLIRILVNNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR8</accession>
    <name>A0A4Q9LYR8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0278p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000278">
        <property type="protein sequence ID" value="TBU17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0278p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17661" checksum="5D5F18D16CA459A5" modified="2019-07-31" version="1">MDAKERFKKLNKENLRVNFDIFQEIELLKKYNFQNSNKANFEKITRILSPFRKKQEISEILNLFQVPETLRDSVFMYSDDIIICNNNLQNIQEILKGVLKHADENNYNLNPKKCFYNAAKAHEIIIHDTIITKKTLLITPDITLITGVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX7</accession>
    <name>A0A4Q9LYX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0518p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000518">
        <property type="protein sequence ID" value="TBU13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0518p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="21955" checksum="7D1D67549A2B0C1C" modified="2019-07-31" version="1">MCNSFSGKNTNENKYRFQIGATPGFIEYGNDMRLECLYVKRYLKTDLVFVEKKSGDKRSNLKTYVDLECTKTLHYLSEIVKSTFNVDVSTSTIDPALRVFHYTLKIVKLLEVYDNDKNFVFLDEVEFRGRNVRCEFKNLFVTAARLRNISVVAAINKYGMECHKIHERAVNGEEFKLFINEINKSCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ33</accession>
    <name>A0A4Q9LZ33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1144p0020</name>
        <name evidence="7" type="ORF">CWI38_0504p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001144">
        <property type="protein sequence ID" value="TBU00005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000504">
        <property type="protein sequence ID" value="TBU13201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1144p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0504p0010"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="154" mass="18079" checksum="A896DE620A8B618C" modified="2019-07-31" version="1">MLTPARRRLMKDLRNIQETIDQKLYATPFEDDLLMWIAVIYGPEDTPYEDGTFTLLLMFDETYPQNPPEIRFLTKMYHPNIYQNGDLCLDILKNRWSPTYDVLAILLSIQSLLNDPNVSSPANLEAANLLIKDEKMYYKKVREIVENSWVDGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ50</accession>
    <name>A0A4Q9LZ50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0537p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000537">
        <property type="protein sequence ID" value="TBU13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0537p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20390" checksum="997093799EE29E9A" modified="2019-07-31" version="1">MNRNSILNNVVTNESFMLETEDDEILTTDVNGSSRIAQSFTNSNIFVTNSSSNQQTVPPPSSMQTLDSDNNIQNLNHEPRHIHRHQDFVLKLEFKYIFTLFVENTFFLCLSVVSDFKNIFKTLFSLYYLIILYLFYKYMRGSKGYNCLLTCISIFLILINIFFAQIYLKFVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE2</accession>
    <name>A0A4Q9LZE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0509p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000509">
        <property type="protein sequence ID" value="TBU13180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0509p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="782" mass="92588" checksum="8655E971EB901472" modified="2019-07-31" version="1">MIKLFIKEKMFFFQFLINHLYCICSPTISFFIANEGNEVREFIGSHEKEENSVKFHNTICSSNDYKVYVLRNEILCFESPQKPIKYFKPEIITVPCAKMLQSSNLIQKSLNYTQNNINIFVKNVSYTAFLLFLKAIENPDGLISQMELVDLLDILKIITTLDISKSFERDFFLKNIIKNILFGLERHSNIFDFLNKFNEFSLNEIDRFLIKDMLIFFINIICFNDKSAERFMIVSTNKGLNLKNQNHFSPYNWMKKVTQTKFYIKFIGRDIYNLYKMSPLPFFLGTWKFLLNIATFEYFYILFQNKRSIEQAIVLFQNTKLNCIRIYIIMKVNYVLIADFFTTIFSNSIQILKISANISAGNVKDIFEVCSNVQKLTIKCTIVTFEFLSLIIKVARTNSTKAYKIRCIYYEFENTDLNSLLNMPINLLFYVDLLRIDTKEVFIVKNLIPFMSQYNLSLTETDIMISYNIFLFDCFKFKELTIVITDSISFVDLDKFTISSLMNFKTLKYLTIKNIKVTTELLMYILESNILVYLNISNFITQIDFKKILEINTQNFKLRYMLLRNSISCFKKEILWYLSRFVHLVGLSLEDIEFRVTKSIIEYFFAYLHSLFKKTPKKISLKRLEIILQSNTEKEADILASLSHIYELSKLNELIYKVYRISNADFKIFSQMNALEAIIIQIYDSDGFCLRNTLSNCQLYASIYYIDLALKKIREDDIIMIKKFYKLTVLFISCEQIDYETIIKFKKNDFKSTKFVLKQPSREKRSKNINDYLDSEFIENFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZM7</accession>
    <name>A0A4Q9LZM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0446p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000446">
        <property type="protein sequence ID" value="TBU13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0446p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="21679" checksum="696509E79579D4F9" modified="2019-07-31" version="1" fragment="single">LDKKKNKITLIEVGITSQDSIQIVETEKLRKYDLLANYLGLNYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIRSIVLKKTVETIFFDRRRGLESGLNAEESWGRASMCVIMRAEMHEEPIPPLKEEKREEYGVKILKPKNNTPLISQGGTTLDEPNNNINEESDLEEETAVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ9</accession>
    <name>A0A4Q9LZZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative IKI3 IkappaB kinase complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0447p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000447">
        <property type="protein sequence ID" value="TBU13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LZZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0447p0020"/>
    <dbReference type="OrthoDB" id="2190800at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1761" mass="201446" checksum="73F556DD41B03AB0" modified="2019-07-31" version="1">MENFFIRNSKIVELKSKDFLYSNKAILIDNKILSISDLEIFCDLETFKSTIIHSNNSQKEIKNENSKISEIIKSKKSYEENMPNTELNSSLKIEYFFNSKYFYFLISNTNSIFLIHKKLNKITEIGTFEHKIILCRFSPSQKYCVILLQNKEIYLLNENFDILKNTHILSDTILPNKYIDTNHIFTTEETFVNLEWSDQNKFAIIFNTQILIYNTELENISVSLNFKPTGSISWNSKYNTFALSSPEIIYFIEPNGLLHHSPLKTHNTHISYIDSNLLLVFNHLKEFNEFKIFFLSNFKWYLKIHKFVPKTQKFLSIHKNIIFLKSENKIIKYYFYKEITSQDTQFGVINGKNIYFYNYQNKIIPPPFSSSSISLSYNVIDICFSNHKIFVLTSTINSEDSNTKYELDSNNPLSIPFVAAINSEDAKTKCEVDSKTKSDSISSVSTINSNDQISIINSKDSKDISDSVLINSSSLISPKISYFIETIKIENDTLSIDSIITIPYTDPCSCQIINISNKKINCNCNSTQKSFTALKHPIITQKIPNTDKKNISNTFSQLLVIDDTIYLKKENSSILKMFNFQNSLSLLTTNHLFMHKNISFILPCIKTMHFQIYLHKNVLLALINNQLHIINIEANTITNTPTSSTIINTQITTTFINTPTTAHISNTPTTSLLSNTPTTFTSDNTPTATLIPNTLSFITNNTYLITSSKHTYSIYKLDPLNLIETLPSDNTPYILCIRNNTTLISYIIRGSIESLTPKTLVTEKIKNYILKNKYEAAITLINTYSLNYSVLFNNNINIKELLFSCRIVNSKCYYTSDKDSLMVNSLITDIFLEIYNMLDKKNNTPLCNDCLLGVIYTDYSSMNNRCGGVNDKGVDIKGVNDKGSDIKGVNEGEDMNMKLRGVNNKDSDIKDVNISSNKQQGVGNSSNIKGVNTTSDEQHPFNNLSNNYHPLNTSPITQHPLNTPYYTSLYITPFTDINLFIFKFLLNLNKIEDFNSIIVILHFIGKVDTALIFSYKLKKLKNCVKILSSYLSYHDIFREGMGCYNKRLVIELAEYCNEYPLIYNEVLKGNIDMVEGVNNISSVVKGVKDKGDCKGVNNTTNEQQGVNNLSDIQHPFNKTTNEQHPSSNTTNDTYCSSYEKFLINDYLGRKEISLYYLLLINDKIKEQEYIKRNNLYISSLKYDSLYNEVGDLTGDNDIGDCKGFNDIGDCKGVNDKEYDIKGVNNSINKQQGVNNTSNCAHDQQGVTNNTPYKQHPLNNSTNEQHPLNNSTNEQHPLNYNTIQHPLNNNNEQHPLNNNTIQHPLNNTPYIYNPLFPLCLKKYFNHSFYISPCNNTPPFINREPGYFYNLYANTLSKEDSYKIYFKIKNLKKTFILSFENSEENNNNSNNISNDNISNNINNKKITNSNNNINSSNITNSNNNIDLPFTFVKVCYSNEDIQTYSSLINLPLNNFLCLLISYLLNNKKYEGVGYIMKRYFNDKEECVYYFNKAGKFMESYYIIKGYSYSREIEGVNIDSSNYRGVNIDSSNYKGVNIYTNEQQGVNKPSDKQYGVNISTNEQQGVNNNNSIQQGVNIDSSNYRGVNNDNSNYRGVNDNNTIQQGVNIDSSNNRGVNDNNTIQQGVNGISMERFVVELKGYFSKSVEEIEKIRISVNKVVEKVDRLFERIQKGIEMGIGVDDVSISSFSGVSEGGRKRGIGGVKKRVDECVKGIIKWKNEWKDLIEVMGVLKMEKEFNLIEGIIFEVERGIKRSEEVLSRIEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M053</accession>
    <name>A0A4Q9M053_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ING1 PHD finger-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0441p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000441">
        <property type="protein sequence ID" value="TBU13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M053"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M053"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0441p0030"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="16881" checksum="B7727A19259800BE" modified="2019-07-31" version="1">MSKTPYETYDSILTEIQSFPLDFQHHSKKIIEIEKIYKRIKITKEISEITKKYLNIIENKMSTNGVENDNLPTLQQNISSVIKAGTFQNSDKNKKKKYCTCKMPSYGDMICCDSLECKIKWFHFECVGIVTAPKSKWYCNACKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M062</accession>
    <name>A0A4Q9M062_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0284p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M062"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0030"/>
    <dbReference type="OrthoDB" id="2192730at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="589" mass="67670" checksum="25B752903B4C8312" modified="2019-07-31" version="1">MDNLPRKRRADFQLSPYAENTNIKQTDTSINKPTDTNQETQRKRARARPLNEHKDIPTLKGIFKNINIPSEINMMESVKGSVNENIEEGMKENGKENRIAGLNKSFVRALEYVINVESSKNLIFLFEQYKKFLKEIENEIFTNPKEKPFSELKDEKKSFFSTNNVTDSVQKKDNINPFSNLLPPSVDRKDSKDSVKDNINPFSNLLPPSVDRKDSKDSVKDNINPFSNLLPPSVNNSDKNDSVKVNINPFSNLLPPSVKNSDKKDNCNPFFNLLNHNSPSTDLSILKEPEDSSKSSFCDQNIFQSDSNKIDSNNFQNPIFSPGLNKKTENKNLNDEKFTENITRPDKKRVSFDLSRNEELNNSTFHDSSFMKSDDSFSLTKSPQNNIFISSSPKTLSNTVTQPFTFYDKHNVKDILASSLRTNPHTTPNPFTIFDKHNTKEDITTTSSPKTTPNPFKFYDSQNTKDILSSNMDTPDIYLQPTNEYLLNNKLQSQNISLYHLNNTKTNNEYILLGKPYIYLKNNFLTIFYSKNKDSIQLFKNKEIQNISIKYTNGDQFIVIGVDNDLNLYKIFFDNFKDISVVLENLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M063</accession>
    <name>A0A4Q9M063_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0155p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000155">
        <property type="protein sequence ID" value="TBU20004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M063"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0155p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="358" mass="41402" checksum="AACAD7B0750EA3EF" modified="2019-07-31" version="1" fragment="single">PCYYFSIGKYINSKNEAFRSMIVKSYGNVITSTSVEIFNSEAEDLINFLSVFPNLNELFILNRGPIKGSEDLSFKFLEEYRIKSLKLQNFVIDSRLLDKILNTSILQNLTLIECQIQIDGDLFPNPYICNNSLDTLNIFDSSFTPSLFYNNFVYKLKNLKKFDYSGKYMIFKVTSQDSKLGGEIVNSDFSLRSSNQEKSGLSNLDPNNLEFSLVALYFKNSSFPTFTLKDVELNLDEVLAFKSMNNIVNLTLNKIKSTESIHLLADILQNRDLSRNIKSLCLINMDLDLNDVKSLNFLSLLENLKLLDIYKDDSKCYFWAIKRCHLRKLKEINIIGEISKNNVNYLKEEFPLRMLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Y9</accession>
    <name>A0A4Q9M0Y9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0100p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000100">
        <property type="protein sequence ID" value="TBU20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Y9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0100p0040"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="30784" checksum="7D3A34D27AE9CA3A" modified="2019-07-31" version="1">MENVEGNLLNLEKRDSKYKELPKEQRQGILEKLLQQIKENKLNHGFILMGKLEYGHLFIKNQLKKITKNRISVRAVHCKNMIIDNVILAIKSKFPPAYKKKTIYVQQDNAKPHFSDNDADIVALASADDWNIKFKAQPANSFYLNVLDLGFFNSIQSLQYEASPHTIDELINSNTLDNVFTTLQACMESIMLADGGNGYKILHLCKGKLRRKGRLLEKYVCSKEEYVKANQILNELLILIYIFFKFYLIFTLIFIKTFEKGNIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M124</accession>
    <name>A0A4Q9M124_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0083p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M124"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="10900" checksum="31F3E0BF498A8BB1" modified="2019-07-31" version="1">MNIILKDCKTPQYRGNHSVHSTQENSRNNSFDRRRGFESGLNSEESRERAENTKNIIHLVLDDINTVKEPTINKDKESCLEENKQVIGNMQEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M135</accession>
    <name>A0A4Q9M135_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0084p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M135"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="59203" checksum="201D44433E6A4B2C" modified="2019-07-31" version="1">MKQKIFSLLENNENEKALSLIENELKLNNSEFYLSLKGYVMFLMNREEESFNTLKMVAYRYPSYSEPYKYFSMICEKNKKYFEAFQTLKISYILGGKTQYTVYKLIGIGIYLKKYEEIFYVVCDYPGFDENTRNIYISFFYFLIKDTKNSIKFCNKIGDEVGDELKAKKEEIKKLINNLNQNTEKLHENKLETDEIPDLNLKKDRIINNKIQRTESTFNETLNTDFKSIFNTNFLNKKIEKFNCFSIEIQPEINKDLFKYVCSEEIVKCSSEEEFILKNVLSGRIFKEIYFYDKKAIKCLSECNIINTDINNKYKNYQNFNYWIYKNDYKTAFHHIKDLNNNRTYKQFILECINMEYVIILFNLCVSLYFNSNCHLSLHFANILIEIFEQQNIDKIELYIYLFEKKRFLDIVNIKQINKKDKSIYLATKQICLNIFTKHKNIDTNNLYCNCGLKDINLKDENTIFFKELIDSKIIINEVIKKFTELEILIINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M155</accession>
    <name>A0A4Q9M155_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0073p0060</name>
        <name evidence="7" type="ORF">CWI38_1130p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001130">
        <property type="protein sequence ID" value="TBU11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000073">
        <property type="protein sequence ID" value="TBU20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M155"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M155"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0073p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1130p0030"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="223"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="32135" checksum="64F1C04CC5F0961D" modified="2019-07-31" version="1">MRYQVKFRRRREGKTHYRHRLNLIRQDLNKYSNAKSRFVVRITNTKVICQIFKAYVEGDRLVASADSTELKKYGIEFGLTNYSASYATGLLCARRALKLLKLEDSYGKGDIDGEYEVVENKEDGPRAYVCYLDIGLARSTKGARVFAAMKGASDGGISIPHRPSKFYGYDEENPEDFDAESLRNRIFGKNVSEYMISLRESDPEKYKKQFSGYIKKGIDPSAIEGIYEAAFAKINENPEKPKKSNGFDYSEFKRFIKPKISLDERKKKIDEKLASIKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M190</accession>
    <name>A0A4Q9M190_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0072p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="975" mass="112358" checksum="2FAE4D4CF59A0F5E" modified="2019-07-31" version="1">MKEEKSFAEDQLTFFKKKMGNTCLGMWSDIPLVKLLKVLFMNECTLRITSLVFWIHILSFSSVRCAAVDIPEDIVGDKCNIFYFNIINEYSDVNISEFLTQSNPRFALRTEGGTFEEKKDICSGTHVDSEDDFCSNKIPRSDHIPIVVKEYVIEGKYDIEFSTIEMMSNMMCNPLSSEGFARSCYMNIVHGISAEQFDILEKFMLKDYDVTMLDITKADFCPMWYFIDMLQIKPSLGTDWFFVKFFKKSVLLSEIYKEYFLERNPEWLSFFSGVDLDAKDENGILLWNKILEVSPCPKTEEDCDFPDEVNDNRSEEVRRYGGNQVVNIDANFGRMFGLLFAAIIRSFYMHLSYSVSNKEFVLENFTDQCYSENMMEDCFKIENGIKLRIVTDVIQKLHAFCSFRKYKHILAIFLGSRLYNSLEVTNVDFEPSKEYRSPAYKKERINDTFNFDGPEPPSTHNTLRKVFISDSFKRIKELKLNMVALGELDPNRLYDLRHLEKLEILNPNCKEVQRCVTKVLRCNIRLKSVKLFQIKISQWFLESISKITPEIIILKKCTLESEGGNNQIDTLRILPKDAKFIPVLKKFVLEGEKNYFFGLLEHISLYENLEFLSLINCFGGNITKDFMDKIALLKNLKVLRVTGNDLNMDINFEFLNNLVNLKEFRIANCDFSLSRLFILGDKQAIQNSLTRLAFRGLKLEDIQYFKCISRFEHLESLDLRDCSCNFSTPFNSEEIYLPPSLKSINIDNIKFAPPTIINIFNGLDKLESVSMKGFEFSKSDSMVRFLNCLNSVINADFSDCCFEGVGVFFFKSMNSLTCLRLFGAKFSSDLNVWKCLNCLPAPYILRALCLGNVVFDSPIVYSTPGANMVNISSLVDTESFLSKASKLNTVSLHLVAFGENSLSKPILERFHKLKRLYVGYDVIFNQSEQLNILKKEIPARVLKIFKCSKTGADVFKDTTDEPIDDSDRGDRAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B4</accession>
    <name>A0A4Q9M1B4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0275p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000275">
        <property type="protein sequence ID" value="TBU17649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0275p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30128" checksum="DACDB32551388E7C" modified="2019-07-31" version="1">MLDKTSEISGKLNLSIACNDLIFHIKNRSAMLEGIISKTETTNNIKDMHDLITSTLYNILFFSDSKYFPEGVSNTMHLIQVDEGIFLDKMRKECHKISNCESMELETLQSALKFAEELIELEHRIYLPPSDNIMASKAKLIGFSNSFHNLLEDCKHMHLTELIKLNNLNNDYNVITIKKGFRLYYSFLSEIFCSQFKRIFDRYDAQNKVFCLRKVLNEYDSYVFFKDVFLLQTFFLRILGSLEGLKIKKSHMEFQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C9</accession>
    <name>A0A4Q9M1C9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0059p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000059">
        <property type="protein sequence ID" value="TBU20514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0059p0060"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21051" checksum="3B30004D7380AC6B" modified="2019-07-31" version="1" fragment="single">LGLIYKCSVELIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPTPPLKEEKREEDGEKSFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEITPTTLTPLYILEYLTLLNSTPLNNRITHTNYLNPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F2</accession>
    <name>A0A4Q9M1F2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0295p0030</name>
        <name evidence="1" type="ORF">CWI38_1739p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001739">
        <property type="protein sequence ID" value="TBU10470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000295">
        <property type="protein sequence ID" value="TBU16696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0295p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1739p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="16878" checksum="39E2C948386C34EC" modified="2019-07-31" version="1">MVNPVMSDSGDYEDEWKNYFKRIISNNENYIKSLELFNLEDIILSHNTESSKAEDFEYFLSLFDESKENSISSVIYKGIKYIYVREIRDDNDSNVLIFMTTENNEEGKKTCAIFNYIVDTDLLIACCNSTDLSLVLKAISDASKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N1</accession>
    <name>A0A4Q9M1N1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0272p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000272">
        <property type="protein sequence ID" value="TBU17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0272p0020"/>
    <dbReference type="OrthoDB" id="2195868at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031541">
        <property type="entry name" value="HTH_micro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17007">
        <property type="entry name" value="HTH_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="863" mass="102594" checksum="FD99D717E2C3EB21" modified="2019-07-31" version="1">MQDLKQKLFSFGIYGTKISELTQEEIILLLEKTWVEIVSHNEIKNLQASFTLVSLPNERLTAYNHYTKNGFDLFLLNFLKNKYIRMETVAWKDYLTNGAFNFVSKEYYLFINLLLSKNEFVHSSELKSALNLQPKKLFYLVKKLASLGLLEKKSYNNGYLVKLIRDENGCILTLKNNQPNINIQPSVRNQLNTDLNTHDLSKNELRFDIPLYEQIRRLVFQSAHGISSHDIFQKFGIKIKVGLKLLTKLSKINEGKIISRDEFDGKIKRTKFYFIEQLEKCKNKSEIFTSQEEPYSGNKMITVEDRIHAIECLIDQKGSFLLDRDNVDELKRILGVKYDLDRRTIINSAIKGGFNVCKSIIKDNNIRYVISDKNAKEDEQIFNKISQKESFEIKKLSKFQQNIYRYFVIYFKFLEKDNGFISDKNIRNKYFYLFLRNISTQKQQERFVFDHLIINEMPLYLILALLSFKKPNFKNFIIEEIRKSLFNGNLNVKKLKTEIFERKIFENEIEKENILFSNIEMEYKNSNNLKDLEKENILFSNIEMEYNNSENMKDEKEMGILYGKVRNFLMESSYGTYVNQKVEIKAFDGYFMDLEKMGFLQVFRSNGCVEIKLLRKEFKEENTIFTFLKNEPYISLKKRENFFYYVKDFPEDDFYDKCYTFIKENYVDEDQLALEGRLMAFKSYFPSISQSTKPTDNIFGKRLENLYIKIKEMIIFHNKLIDLNFKGFSILDLKKVLSLLTSQKIIRNYSSFKNLHLIEGTDFFKKKISFKLENHSFFESSNFLEMILCTVEHPNEYYKCFFSLIYHILMINGSMEWNILLKNIGIMMDFELSNFFEIYKSVFEINTCEIVRFVSIRIKDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M209</accession>
    <name>A0A4Q9M209_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_0218p0060</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000218">
        <property type="protein sequence ID" value="TBU19128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M209"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M209"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0218p0060"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="473"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="19">
        <location>
            <begin position="802"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU19128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="957" mass="111746" checksum="99F198D61E2BA624" modified="2019-07-31" version="1">MNSVLKFSLLFLISILAFVIRLTGIFKYEPILQEYDPYFNYKCVKHLVKHGLLSFIRWNDMTVWIPFGRKIFNTSYPGMMICTYLLYCISNSFLFLLSHLCISPLTLCIYFPAICSIPTTFSMYMLCNTLFDRSSCSLLASFLYALCPAYISRSISGFYDYECFSMLLILLSFNFYIQLFCIKTEKTVYKCINKMHKQKKKKNENELEEYKESKEVEEIDKSKEECKAICKEEYEDKCKEEYEIEKSKAICKEESKEECKAICKEEYEDKCKEEHEIEKSKAICKEESKEECEEKYKIVESKEKNKCKSMNFLTNNFKPYFNTFICFIIFYQILCFSWGGYTFVINLISLHSLALIVVGFIYTVIDRYTFKGRVKGVNTRDSYKEDVKGVNNLDSNYNGVKGVYDKNSNKEKVKGVNTKDSNIEVVKGVSTSTFKQNPLSINTCKQDPLSNTNNHNSVLYNNTLLFIDNPKGYSEINYWVFTCYFIVSTLITYLVPFIGSKALFSQEHLFPLTVFILHQIIKGMNIRKGNKILFSVFLLSFLLIFFKKITFLIQKLFLGRGRLLDLILRKKGTSALVNSVSEHSPRSFYGFFLDFHFLILIFPLSLKKYLYEHKIGVKSIFVLLYSLVALFFSTRMLRLVLLLGPIVCITCSYYLIYLIKKCQKNLTGNISDIVKDGNKCDMSEDGNKSNMREDGNKWDIGKDVNIDDNGNISNNGNMSDINDSANTRNGYLTDMTDIGSSIFNIGSLFVLVYLLFLYCLHSVWITSNHYSVPYVILYNSRNEVMDDFRESWSFMKNNIKNENVLCWWDYGYQISVMGEVNTINDNNTCMGERIALTGKIFLSEEKEANLLCKKENIKYIYCVVGVSNWYSSDDLNKIGWIKRIVSETFGESYLSINRDTEEYKNMLLYKMSYHKMENVVGNMWDSVRRSRFDKCEIKYFRNIFNSENYLIRIYEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D4</accession>
    <name>A0A4Q9M2D4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0122p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000122">
        <property type="protein sequence ID" value="TBU20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2D4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0122p0010"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18137" checksum="DF89771EBD741B5E" modified="2019-07-31" version="1" fragment="single">MQQPPPQNHPLNVLIANLSSSTPDPYLLQLYERIKQYLKENGSKLFLTEYVPLLLQHPFCNVNTYGIHAVNELFKILQYLTPQHTDIETLNLLRWTNHYIPLNKYIINTSNKDILKGVNYKERETNMKECINKEIIEHKPVPNPTPTLNNCINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M9</accession>
    <name>A0A4Q9M2M9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0197p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000197">
        <property type="protein sequence ID" value="TBU19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2M9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0197p0040"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="114"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="35718" checksum="C69FE7D4E4492578" modified="2019-07-31" version="1">MISFIIKKANEAFESLTGMKFTKCSRSPFDINTNDENQTNQSEEIIPKKIEYMVPFNVKKSYSFFIKYGNLTRSERIYLSEYCFINLNNISRCISVTKIIFIVKGFFTKRKNFISLKRKINPFVFELIDYLKKDGTDKIGIFRIPGKSNIYNQISKDLGEGKTYHIESYDINTNASILKAYIREILDGLIPIEVCKALFEITNQNDQEKISKVREVLPFIFLEDYRLLIIKIIDLLKTIDSHSCINKMTMSNLLIIFTPTFFPKSVTNSYEILALEGKILEIFTYLDFENISLVLLLEAKKYFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T7</accession>
    <name>A0A4Q9M2T7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0001p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="300" mass="35396" checksum="20AF4FA876EC79B7" modified="2019-07-31" version="1">MFFDYGIFYYKKVSIINLRSKIIISNSDVKVVPFNIKINDLHGILHEETSNLGKIIEKPSKILKMEGDAKNNLKIFLGLTNSYIPSISNPTELQKSILEILTENNSKYESITDKKIYGHLKFSKKKNKNIFDSQNDKICLYLYSKGEKVELSEQNKFINNFHNEFCTKKAIENSTLELEEEYTEMLNNIYRVIESPEIEIFSNNENINFLDFLLEKYTKLRNIENIVSLYKENLKLCSINNNHYPEVSVYNHFVVYLNDRTDINLCKIKDFWFEPTTCNEKGILRFIEDSLFKLNKKDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2U0</accession>
    <name>A0A4Q9M2U0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0088p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2U0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="544" mass="62115" checksum="EBD422D1CED08279" modified="2019-07-31" version="1">MKTSFKKNVSDSLRYEAEDCYIQDRNVFWGQMFGKTLDHLATRCEKRLSYGYTGQHSEVDRYLYLLLLNRYKFNLQKELGNRNNRAGIFILDKKKNKITLIEVGITSQDPPQIVETVKLRKYDLLANYMGLIYKFSVKTIPCVMTWKVIVIKTIGHTPKNCKYPSIAPMGVVERADMLEKPKILLKQGIKKVDVVKYEPTLNLNEESNLEEEKIVVKKIENSHVYKDIQHNTQMLLLYIIIVSSINIHDFLDKKVIEGSVVPNNIDNVYINKVDNNMYNVTVGGVRICQKKSKTKPLADCLQGENVKLTWYIKPKKDGFAFKGDYILWPLDIRRMCITRDGNTLTLEKCRKDYKNQIFHIELQTDGKKPSNDLKKKEKKPSSSSSSSDSDENKKKGGHPSSSKPSHEDKKEPEIYDPQDPKDPSYIEAHKPTPDTPKDPTNPQQPNTPTDPSHPQPKPDVLKDPEHSPPIITKDGDRVDLSGIKSPSGKKCVRKVINNCKESKPGSGKPHISYKAISKPSNTYQHSSYSGSYPSGYSYSHYYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M335</accession>
    <name>A0A4Q9M335_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0072p0040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M335"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M335"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0040"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="39884" checksum="503BD2DFEB7E7D33" modified="2019-07-31" version="1">MVSDEKLFLIKRNLQEILSEEILTEKPKNEKIKIYWGTAPTGRIHVAYYVPLLKIRDFLIAGCDVKILLADIHAMLDNLKSKFEVVGFRTQYYENCIKAMLANIGVDSENSSFGKIIFIKGSDFQTSSKYVMDLYKLSSITTERDGKKAGTEVVKQVSNPLLSSLIYPLMQALDEEYLDVDAQFGGVDQRKIFTFAMKYLPQLGFKKRAHLMNPMIPGLNSEKMSSSDKYSKIDMLETKENIEKNIRKCFCEEGNKETGLLYLIRHIIYPIFEIKNLKVEIFIKSLNKKNFYEKYQELENDFVEKIIHPQDLKKSVAEMVEIIVGPVRKEMEEFQELIQNAYGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M338</accession>
    <name>A0A4Q9M338_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myb-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0171p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000171">
        <property type="protein sequence ID" value="TBU19926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M338"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M338"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0171p0040"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF274">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="554"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="5">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="606"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="611"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="664" mass="78411" checksum="4EF6289CB742DFD0" modified="2019-07-31" version="1">MNNSNTIFSIDRAESKQEPMPFRKAMNHRYTAYLKTLAYDKPIAFLHKEVCDNGEIRENTDLSNYASLDKNQILRNGAENKNSVRCTALKADTMIQNSKEVKNNVWYGKMLEVLKKMKSQVRTMCYTPIRNFVVEKILNNNIFMKDNATTNFDGYAFFNIDDLKLPKKYFIEDNNLINESEASRYSKSNEIDLKKELLERHAKMIDSEFMVLNILYIIGFDEWKKIHLRCDTCLLLLGFIENWKKHYDFSRCYSIYVGDLKTSLCLVHRTDGCFKKLKRKSYEYPSKRVKIYTDEISVRRTPKRKASLPQTNPNIKNKKKNIESIMKNESNSKRQMLNDKFLIRDNFNKRVKTNNYSVEKKEEITKEFPMIDTDEFESDNINTSKIYSPNDVIFDTESNNKQIKEIIPNLENSFKMEYNKIEPSNSLSSSIIVEENTELKDSEYKVFKDLSFFKKNFSDSHDTCDLCTNSFVKLKINKEILEKEKERLYEHGIFKLSIDVKRIENTEDNEKYIGNYQARHENIDDKVIQTKNSPNKPLFSNNQEQNAESNTESKSKHKTGKWTADEDKKLLDLVQEYSYENWAKIAKLIETRSGKQCRERWKNHLNPMVTKKPISEEEASIIFEAQSRIGNKWCKISELLPGRSENTVKNFYFSYQRKHKKQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3X0</accession>
    <name>A0A4Q9M3X0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUBPL iron-transfer P-loop NTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0092p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3X0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3X0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0020"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="26877" checksum="C140AB2351BD1E21" modified="2019-07-31" version="1">MRKIAIMSGKGGVGKTSFTSLLACILQEKYKVLLLDFDICGPSLIFPFGVSGKVKKNENGFIPIKLAENLDILSMAFMIKESDSVNWRGPKKNILLEMFYNSRFFKDYDFVVVDMPPGISEEHNFLIGKDFEAVLVTTSQNLALNGVIAAYNFCIGADIKIIGLIENMSGLVCDECGTVNKIYSCKGGSLVAEQFNLIFFGFLEFEVEMFNFIDSGKLLCEYKKLKSYNKLEEVIERYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M418</accession>
    <name>A0A4Q9M418_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0098p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000098">
        <property type="protein sequence ID" value="TBU20276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M418"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M418"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0098p0040"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="24138" checksum="C4E1747CA5DE4D2E" modified="2019-07-31" version="1">MTKEHNELIDNTFKQLQKYDNILAYDSEDVHMEKLSTLVNGEYILVDLRVSEMLKNKFLSFYDVRELPCYISYGVRIYDDDDFEENVKKSLENEGKFLENKIKNIIETDKITIFIKGTPLRPECGFTRQLIEIFDEFNFICGKDYVYFNIFSDNRVRERLKVVNKWPTFPQIYVKEEFIGGLDVLKKMKKTGEFQRKINFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M492</accession>
    <name>A0A4Q9M492_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5090 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0080p0060</name>
        <name evidence="4" type="ORF">CWI38_0001p0080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000080">
        <property type="protein sequence ID" value="TBU04852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M492"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0080p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0080"/>
    <dbReference type="OrthoDB" id="2190291at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031539">
        <property type="entry name" value="DUF5090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17009">
        <property type="entry name" value="DUF5090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU21037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="201" mass="23295" checksum="C7D788E9621F15CA" modified="2019-07-31" version="1">MSENKTDKYKETAAAKAAEAEQKVHGTVEKVEKSSYGKKIPTSFEKVKFINIIKANAWINFIATIPIYIFIVEDTNKASKFKYVTKFLKYLFLFGGLIPVVLDVIAVYLKMPFLFKFIILSKTIKAVLIILSMLVIAFGALYVRLLAYFYMMMVILLDFLFVYYIALLFKRIDSEEYDNEGEKIVRDQPKEENKTEQKTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4A9</accession>
    <name>A0A4Q9M4A9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0082p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000082">
        <property type="protein sequence ID" value="TBU20376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4A9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0082p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020523786" evidence="2">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="585" mass="68785" checksum="AB06DBE900722412" modified="2019-07-31" version="1">MSFLVILQLITNFGISATAPQTPPVAQPQLNQEKVCSLVATFEQQDPLTNRSFQLLYLPTIDYNLNCDISIIISEMFPNTDFDAVFNKKIEPLVRFYFSYAMKVTEQYCHEFLKRFIAFVCYLTYFDEFLKKIDQPHIEFCPNIELLYNIVAFAAAYNLSKSNKEFEEKFTEFEINTIISFDNSFRLGRDYEPERNEEETEDFLRSRSISIGINDINADIVNQKDVECFSKEKTVFYDINTNKWAHFILTSSFERLFSMFITLKHIEFNRPEYSDDYGYLGKKCKPIFLGLFVFLEKTAIWMPDFSFLTLEIDEVKAFYNKFLNLYDPTANRGDLAVDVFIDGVLDKSMEKNTNDEFFSQRLIKQCYGDLSADDLEKMRNFFNILCGINNKYEISVISALLSLKTSSIVTSDLYEKIIRMVFEMLFYIKTYSEVQMKSYFEPKIKRCVHFVKKELIAKGYKFDNIEDLADMNREYISDTELEVICRAAVYSNGFLFCKNSFAIETIQLLPKLAYTESWLNEAILRFITTGESSEYPIHEPIMDKNTVKKQNQTNWFRIGVFTVLLGYTISLVIYLYFVIRYFYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M517</accession>
    <name>A0A4Q9M517_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0016p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000016">
        <property type="protein sequence ID" value="TBU20852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M517"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0016p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="103" mass="12494" checksum="B9F7F582D32227ED" modified="2019-07-31" version="1">MLGKRTNSKERKSKLGNRKLRYGKKNQRKKLITHLKRVSKEENENCLRKYFFIKKKIGECNSCRTKHLIKKEKNSSGKENWDRENKGLWKKILLSNEKRQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M575</accession>
    <name>A0A4Q9M575_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0028p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M575"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M575"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0030"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="250" mass="29368" checksum="441703F074F9DED5" modified="2019-07-31" version="1">MMKYKNKKDNKPCTKDDIEELGSFKHKCEDLIIISVTNANIPYPNSMVFSKKLEQIGKIDEVLGSFDDVYVSIAPTDNKTEKFKEGTVFYCDKRKLMPKSRFISRTDTEKIKEEKDKRKNNDSYKNRNSSFNSKEGGGYRNKTNDSYKNRNYSFNSKEGGGYRNKTNDSYKNRTSSFNNKEGRDNSINRNSNFQDKNNRNQFNKNSNRNYSSNTSNNTFSRNNDKSKYNLQKRDKPMNYNKDLDKRKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5K1</accession>
    <name>A0A4Q9M5K1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0015p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5K1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="721" mass="83208" checksum="8E322FEB86FEEF43" modified="2019-07-31" version="1">MKNNILKRYFVLGMLVMFESMKTAQLFYFNEGKSDKKVYTDSQNNFRSTRNDLRGCNINGNVYIYPIQTTVSLSVTVLVFQMKNKQSIRNENEKRSIVKNDEHSRTRRESTSYLETNTRQYDSQARIDTSCRRKETKNESKTTQDLSIFCDKGISRNEEEMYQGSQHTGIKNQLFSHEKEKSKSEINWNKTVTKKENFNYNVKTVTSEDEPLRNRDPSPESIASIECLNEELYGSLQEAFSESDEEIGKLMPSLNLDSFITTISDNKKPLNLRKENFIHTIHPYIKEQSDTRSYSTAIQQDITQENLFDRNNGKSKKELKPESTLLVKSTSRMENNEINDILQPVKNNKTSASPNIKPILTPHESGKDKGFIFPSSDDKTQTCSKEENIGDFRFKNKNKKQISWEIYKLESVYNTPAPIFLQNESENLLKSSKNCLECGHSSGNENGNHIFTSIRISSNDYPNRKYLKASRKTNGRRKPVCLQTIKCVKGKAKENDMGGLPFETNESISQTNPFYKQSKEMSKKNYKTTKEEFLGINDNRSEKFDAKGETSVEVTDIKMNTQFDELNLDQENPKRVLTTQEFPNPNPVPPNSIKNQNDDTILTREECNLADLGFDQVCPSKKPEKTQIKKIEDGLKKCTSLFRQFGLKDHCKPSNSDAFRSENLFVSKPISRCKKRFINICSNQIYLVTERIERFGKIIESQIDYCELPVTIVRSFLDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5W6</accession>
    <name>A0A4Q9M5W6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_0005p0170</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5W6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5W6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0170"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="396"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="817" mass="93070" checksum="2462E4489E2F8043" modified="2019-07-31" version="1">MPKRRITDSSEENENIFNNRNPEQLLSEDSQGEDLFEEDYEKDYREMPELDSYDVSDVTDEIEPLTMEQVQFVNEQLDEQKRRTDRLINPNVDDQEFELNTEQLLADAMASKDFMDKDFFISNLTNLLIKFLSTFHEKKYVKEIKKMCSNNQESLYVSFEDLNLFNSDLARLLNVATERFLQIFDKSLVVVVVQHFPNYLIIKPKLHVRLTNIPVLENIRNLRNEHINTLIRVTGVVTRRTGVFPLLSLAKYTCHQCKAVFGPFTVERNDFKPNICLECQSKGPFSVNSIETIYKDFQKITIQEIPGTVPPGRLPRHKEVLLFYDLIDSARPGEEVEVIGIYKNSYSYSLNIKNGYPVFFTVIEAITVIKKEDEFAFKMTDEDVKEILKISKHPNIKNIILNSIAPAVYGHKDLKRAISLAMFSGVQKIMGNHTVRGDINVLMLGDPGTAKSQLLRYVETVFHRAVLSSGQGASSVGLTASVKKDSVTGEWTLEGGALVLADRGICLIDEFDKMNDGDRTSIHEAMEQQSISISKAGIVASLNARCGVIAAANPTRGRYNSSLTFGQNVNLSDPIISRFDILCVVKDVIDQAEDERMGRFIIKSHAGSSVEEKEKTDLENKEEAYDSVTGTLSQEFLKKYILYARNNVKPILKEIDLEKITNLYSDLRKESISSGGIPITARHIESIVRMSESFCRMGLRSIVSQEDIDQAISVVLDSFIGSQKYSVMKNLKRKFRKYLENKEHEVLIFILNEIYKDKLRGLGERTSSVSFNSVDFERKVKSNGLKIDSLFYDSESFKDAGYSYVVNSKRIIRNVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWI1</accession>
    <name>A0A4V2JWI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2312p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002312">
        <property type="protein sequence ID" value="TBU08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2312p0020"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="12943" checksum="4250907D27A7C2BB" modified="2019-07-31" version="1" fragment="single">KLHYWTYIPISEQHMLENIPNKVRKKQPAYINNIPMYQMPIFYNNYNPNDPSHMIPQNTYQYNYPTYPINYTIDELYQRNYYPFYEDSILNRFNENENNEENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA8</accession>
    <name>A0A4V2JXA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1407p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001407">
        <property type="protein sequence ID" value="TBU11062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1407p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="347" mass="38858" checksum="3F1E958981510B4F" modified="2019-07-31" version="1" fragment="single">MQFTSLLFFFSLDKCSRRLIVDRKKVEHVLNDFVSMIHIERKYLNLSPRNTNSHKVCIANKYISDLDEINDSKKISKEFYEATNLTFDEKFSKDSKISSKEYFCNFQSLIENDCLDIKSFMTNRPQIFKVFGGTNPNTLEWPHIAHTEQLKSFKRPPPPKKKHLKQQPSAQQTAGQETAEQPIAEQLSQGKPPIPSKPEHLKKKPSAQQTAGQETAERPIAEKLSQGKPPIPPKPKFEKKTLATPGEPINTPITTPGQPITTPDQPITTLDQPITTPDQPITTPDQPITTPDQPITTPDQPITTPGQPITTPDQPITTPDQPITTPDQPITTPAQPITTPDQPITTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU0</accession>
    <name>A0A4V2JXU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0531p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000531">
        <property type="protein sequence ID" value="TBU13102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0531p0020"/>
    <dbReference type="OrthoDB" id="2194310at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20069" checksum="E91B70DA7ACF2D96" modified="2019-07-31" version="1">MERKKLSSEDIENMKTILNPYPVVVENFLDNIENLTDLKEKLEEIEELSSIMVAIDVCGNPDVMNKFERIMKMMEQKELYGAICRLFADCCQNFDVVQAKLVKIKIFEKIKYNWSLNDSTYLLFSLCMNNPAITKLFFSKYYRPDLFDPGNDRIGRLIEYYGSLEATTNALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY50</accession>
    <name>A0A4V2JY50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0206p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000206">
        <property type="protein sequence ID" value="TBU19516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0206p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="33988" checksum="583316A52934F79B" modified="2019-07-31" version="1">MKRFIEVIDSKNNSKYKNNLCNKFKSLSMRLSEFQDLLLPIIFILLVRSTHNRLLNIFKFMFLLHSGYKIYRKSCEKNGKKYIKDNNNLEKMFLIVCSTILCYHITKNMFTMFKMKEYLNIYTKALIYKDANRLNYSFIMKFILIFGFGLYSVLSPIIEFIQKPEYTFENIRLNFFNGKLFIHEKDKKLRKYDLLENKTVLCQNKTRYISKSINQSIVLKKINQISKRTGKESKLEPTPLLKQASNKEDDFKHLKQKIIPLILVGVTTLGEPTIKIKEIRIQNRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVF8</accession>
    <name>A0A4V6MVF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2687p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002687">
        <property type="protein sequence ID" value="TBU05882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2687p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="18116" checksum="FB9BBECC8F79D9BA" modified="2019-07-31" version="1" fragment="single">YDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGPKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVJ6</accession>
    <name>A0A4V6MVJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0446p0040</name>
        <name evidence="4" type="ORF">CWI38_0808p0030</name>
        <name evidence="3" type="ORF">CWI38_2128p0020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000446">
        <property type="protein sequence ID" value="TBU02606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002128">
        <property type="protein sequence ID" value="TBU09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000808">
        <property type="protein sequence ID" value="TBU12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0446p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0808p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2128p0020"/>
    <dbReference type="OrthoDB" id="2189693at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="194" mass="22811" checksum="19423F5A8882B644" modified="2019-07-31" version="1">MFDEALFKNLLNETSSLIKNLEESKDIEMEDRISCNVLALKVLANDIEDEDLKSSVLKKIESIYNTGIYMSDNINNEYQIKGDKETKIREKSKNDKEMANIEIRETDELRNRLETDLLNYSKLLNQKVKNFKTKIDEDTEVLQNTENIFSKNLFGVEDGVSRLRKQVMGGFSPLRMLFLSIFIFLLMYFFIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK8</accession>
    <name>A0A4V6MVK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0071p0030</name>
        <name evidence="2" type="ORF">CWI38_1496p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000071">
        <property type="protein sequence ID" value="TBU04927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001496">
        <property type="protein sequence ID" value="TBU10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0071p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1496p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="143" mass="16969" checksum="F4B0FC029025E702" modified="2019-07-31" version="1">MMKVKELIQLWENRIQVNKANDKTEYMFSEESSVFIAESNKRSDGLEIKTIDIVFEENHEKIDIDKSTTENLIENTPIQNTRQYSQQDVLDLINEMVIKIKNTRIELTIPEENYKKTKYKKRFKNRGYSGSHYTMIGIKWATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KQN1</accession>
    <name>A0A4Q9KQN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2607p0010</name>
        <name evidence="3" type="ORF">CWI38_1211p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002607">
        <property type="protein sequence ID" value="TBT96958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001211">
        <property type="protein sequence ID" value="TBU11430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KQN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2607p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1211p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT96958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="73" mass="8304" checksum="88086258462751DC" modified="2019-07-31" version="1">MGVIMRSEVHEEPTPPLKEEKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYQ3</accession>
    <name>A0A4Q9KYQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1100p0020</name>
        <name evidence="2" type="ORF">CWI38_0227p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001100">
        <property type="protein sequence ID" value="TBU00137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000227">
        <property type="protein sequence ID" value="TBU18862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1100p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0227p0010"/>
    <dbReference type="OrthoDB" id="2193888at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="78" mass="9269" checksum="4481F8B5F304ECF6" modified="2019-07-31" version="1">MTKRVKHKRRIICFRMYVISNLGRLASIDTTIARFQFVSILTNNLESSVRNFSLEEYIFQQDIDSKYTSKVTVEFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L657</accession>
    <name>A0A4Q9L657_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0376p0010</name>
        <name evidence="3" type="ORF">CWI38_0093p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000376">
        <property type="protein sequence ID" value="TBU02994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000093">
        <property type="protein sequence ID" value="TBU20297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L657"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0376p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0093p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445385" evidence="1">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="238" mass="28122" checksum="B96D1A9918D52509" modified="2019-07-31" version="1">MRIILLVLDLLLQLKKVSSWSHPVFPSKFITARMMTPVFYCTFYITSTISTSNPPTKIENLPEDERSFPKTYIKKAISFYFSYYYFYSCDDENIENRRKKMVKEKFMEKLDSDNGLDESIKEDCELNFENSWSGLRFKYNDEIFGDSISKLPNITYQVFFFCDLIDSALIKMMLRIENELINDRLLFISLVESLCNSDLFIKSILPSLLYAKTHIEPLNDEENVGLRKHIEFNNSKWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LB28</accession>
    <name>A0A4Q9LB28_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="4">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_0166p0020</name>
        <name evidence="15" type="ORF">CWI38_1006p0020</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="4"/>
    <dbReference type="EMBL" id="PITJ01000166">
        <property type="protein sequence ID" value="TBU04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001006">
        <property type="protein sequence ID" value="TBU11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LB28"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LB28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0166p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1006p0020"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="2"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="13">
        <location>
            <begin position="82"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="490" mass="55525" checksum="A8CCAE6B254AB31A" modified="2019-07-31" version="1">MKKVCLIVIDGWGINRKKVKYDAIRAACCTNMKRLSTIYPSFLLKAHGKDVGLPKNMMGNSEVGHLTIGSGRIINQDIVRINKSIKTREIKQKLSPIIEDTNTLHLIGLLSDGGVHSHISHLKSILKCLKNSNRKVYIHMIADGRDTSPTSFLKYYDDIKHFIKKIKTGSLVSVIGRSYAMDRDGDYSKTDIAIENMVSGANVSKSFKYEIKKMYAKGITDEHLLPVFVEEDGRIKPEDSIFFFNFRPDRMRQIVSRFISRQNKVYTMTHYFDSIATVIFDIEYQKKTLAEVISDKNLNQTHISESEKYAHVTYFFNGKREEPFPKENRIHIKSPPGPFDKCPSMSLNQVTESVINEIKNGTDFVMANFAPPDMVGHTGSYEATIEAVKATDEAIGHVYNLCRKKGYVLVITADHGNAEIMKDEDDEIVKKHTKNKVPFIICQGEGTGKYKDLGHSLVDVSPTILNIMNLDVPKEMTGRNVLNDYENNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCQ1</accession>
    <name>A0A4Q9LCQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muskelin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2734p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002734">
        <property type="protein sequence ID" value="TBU05637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCQ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2734p0010"/>
    <dbReference type="OrthoDB" id="2188291at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU05637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="35258" checksum="FB903F09913F167C" modified="2019-07-31" version="1" fragment="single">MFTNRFLSHKIDYTIHSYSSYSSTYYPSNIKTDLPHDPTSRWSSSSNDQKQYLILELNKPTIVTSITFGKFSKIHVCNVKEIKVLSSPFRVDGGNNSKDTSNYFSKDSRDTSKDNNTSNTNTYHITNPNPNPNTWINNTNPNPNICINKDIFSLPFIEVLHTSLYNDTEKETFLLKVTNKNTFILTRYIKIIPLQAWGMNFNYSIWFIGLYGIDMCKCVIPLQLQYKQYQSVRLILKYLQRNEVKGFGDISRDSVRGDNDIGCDIKGDNNSTSDIKGDSIKDSDIKGNNYSTSDIKGDNDSTSDIKGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCV0</accession>
    <name>A0A4Q9LCV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2725p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002725">
        <property type="protein sequence ID" value="TBU05688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCV0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2725p0010"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="300" mass="34044" checksum="656D3BEB33AA5346" modified="2019-07-31" version="1" fragment="single">SERDVGDKNNKRNRSNKDEISERDVGDKNNKRNRSNKDEISDNIGNSNKGDNNKGITNKGISNSTNIRDKYDFCREYDLPVKGMDTGYRLYKHLSRKGYSNRGRGVNNRGILEGVNDIGNRVEGVSDRGIVKGVIDKSSKEEGVIKSTSKEEGVINNNIKQHPLNNNNIDKHPFNNTDTLTLHKVFSKAFNYNISLRQKDGSYICIRSGVKVYIHPSSACYNKRYKKIVYVDLYGGDRIYTRIVKGVDYNNDVLEGVNDREGVDDNGLMIEVINKRVLMISKGVNYNIVYYKGVNDRGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDS4</accession>
    <name>A0A4Q9LDS4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0038p0030</name>
        <name evidence="4" type="ORF">CWI38_1049p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000038">
        <property type="protein sequence ID" value="TBU05201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001049">
        <property type="protein sequence ID" value="TBU11764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDS4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0038p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1049p0020"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="458" mass="54785" checksum="BC9EF9AA9EA0260D" modified="2019-07-31" version="1">MRRRNYDQRYMDEPIINMKYLLEQPFIITEKELKHLLPEVDYSTYLKSFYSKKIHKFYNSFHEHEWFKERYIYDDYNIEKTKEFLQNYVEFTEKIVKICWDNTNEEIKINVPILNEEYFVDPELINVPKYNIIMKNISSLVPISLIQSLALKCPNSTKFSVLQSDDRESYKRSCIISLQNENNIDDSVRSMRNKSSPSCEFYCDKFILNENNMSFANVSFSQKDILFAKKIIKSLSDRYSVPDVLETIQSDLQSFFVKYIEKNLGENEKMKKDAIFKFDKSEILDFYILLLRYVFHYCFYCCRMFGSHMEMARCCGKYHIRSHAKNRDFFTRKLKIYTMDKDFSFMKDIKEEDGMIKHIIKIDEEQYKCNSCIKVFAQAHNVANHIKRKHPELIESIKKDMEIFSAFINKLDPFVLSIIEGINDTHLPSYLLKIEEDIIPVKYDIPKVFSGFLDKPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEZ3</accession>
    <name>A0A4Q9LEZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2727p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002727">
        <property type="protein sequence ID" value="TBU05671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2727p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23624" checksum="92FD56508C591B17" modified="2019-07-31" version="1" fragment="single">KLPKFQNINDYNSVLKEKIDLFSTLKKNYLIKAYWRFKSRVAENKNQKINTEVYYFQLEAFYSNCIQELNKSTDLDFINLISKKVYSIEYKSHCEGSFDSTHYSREITIYFSWHYMRSYFRFYREENSTKYIFKSSLFNHFELFEMIFDGYLNITDVKNKVKKNIIWKKGLIIDRYENICYEFLNELCCRIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGR8</accession>
    <name>A0A4Q9LGR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2482p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002482">
        <property type="protein sequence ID" value="TBU06936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2482p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020749484" evidence="2">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="456" mass="52690" checksum="AA61A92895781302" modified="2019-07-31" version="1" fragment="single">MKKIVLLLALEFLIQTETFHQSQSNNYFEDELKIERIKDHENILESSKSLGTNNLYEDNQQTDPNKEYEANKNHDSNLKNNNDFHLEDAQFDAEPFEAKHLIYEENSVEKPENTSMNSIVADQEDKNFESICSPKNKHEEINHDKDINEEVLKVEQFNEEKQKSFLENEIVLSSKMGRMSLDKNERILIEDETDLIDNFNENDTGFENDKAGRPSIASRLSNEKRPEEEQYFERNDSTDRDLDSDQKNSVDHENLDSMKIVEKTEEIDVENIILVPENNKIVNNKNTDVSLDFSFKESSLGSINLGDNDLPSQNCFLVDSNKNEEMNDSTSKEDSDGWECTEYCLEDKKEDSENNEISNTGKLDRNFDTENSVLEAKSNISEEKQIKDCTSKSKNKYSAFAFIDNIFSVDSKETIIKENKENTKDSILLEDCLFENNNFVNEKPSLQNISIISEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKL6</accession>
    <name>A0A4Q9LKL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2223p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002223">
        <property type="protein sequence ID" value="TBU08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2223p0030"/>
    <dbReference type="OrthoDB" id="2188448at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25730" checksum="ADC0AE2BCD5FDB68" modified="2019-07-31" version="1" fragment="single">MKDNSTTSINTENTEIVNNDSSEKNTNSLELSSTIIQLLIELNERDYDSSFNQIIEYLETHDSNFVEILIQIIVEVPYNFYLYSLLIIDISSSLKSFGIKFSEKINFYHKKLVKDNDALLLVSFYRTINILEFVGFFKPNQVKKFLNDEEYNQISLFVTGCKSIQHSLKGMDFEENKNFEFDLENDIFYSDELKKELINLQKYKKFMEIFGIENGDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL87</accession>
    <name>A0A4Q9LL87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1025p0010</name>
        <name evidence="3" type="ORF">CWI38_2230p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001025">
        <property type="protein sequence ID" value="TBU00381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002230">
        <property type="protein sequence ID" value="TBU08686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1025p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2230p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="87" mass="10583" checksum="917125372821809B" modified="2019-07-31" version="1">MSSEGFWKKIYQKIKNSYTRFYEMRNTKDCPLKFVLSKERELLGYEKQVMAKKREYFHELLNSSLKDRKSGINNNDNKPKNKENRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM71</accession>
    <name>A0A4Q9LM71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2148p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002148">
        <property type="protein sequence ID" value="TBU09448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LM71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2148p0030"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU09448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18379" checksum="01D2D322E64F6B61" modified="2019-07-31" version="1">MASVIMRCGEGKVWIDPNEFTRISNASSREQVRDLIKDGFIIQKPQVVHSRFRARERQKEKAKGRHMGIGKRKGTANARAPVKEIWMKKMRIMRKILREMRKSGKITPTEYRKYYLQVKGNTFKSQKILVESIERQKLEEVKMKELSEQAQALKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM90</accession>
    <name>A0A4Q9LM90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2146p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002146">
        <property type="protein sequence ID" value="TBU09469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2146p0020"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="11484" checksum="E0C80BC29470EB82" modified="2019-07-31" version="1">MWWRYMVEVVGMVVGSGYGSSVSDKDILEGGVSKCIDYYKGVSNSIDYYKGVNDSIDYYKGGVNDNTNGYKGVNDNTNGYKGVSNSIDDYKGVNNSTNSRVLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNB9</accession>
    <name>A0A4Q9LNB9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2098p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002098">
        <property type="protein sequence ID" value="TBU09879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2098p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="26911" checksum="B7790038097FBC98" modified="2019-07-31" version="1">MKKYINDLSNSTEIFQESKILTQLYDSVKDIFKIEQKNITEKYIARLWLQIYEILTCLVISLIFISKKARKIIFKKLNESNTTEISFLTLKKSEILYFTLFVILIFISTIIKYLLFGCRIGFDAFDFRSRIKQDIPIIVIIPYSSLFLASLFLKFWKRKYLYILIIGLIIYTPIVRNFKKMGDPTIAGYERIDPTTLDIQIQEAITKCELGNDIFVKKTGSFLRMVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNS4</accession>
    <name>A0A4Q9LNS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2133p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002133">
        <property type="protein sequence ID" value="TBU09616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2133p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="46602" checksum="977CD868B441DBE9" modified="2019-07-31" version="1">MKKNIIHAIKEYVIIFFYLQTIFSGTHSTNNFSCNSNDIAQNTSVSNKNSQIPGQKNGEILNAKRKNTGSAACSEPETLFKSSQKKLKSDGISKHTFRGNHSAYELTPSNQSNPGLTKNNISNNKQNNENRDVSNKKRINKAMICTNTFLSLEPYNKPLDLTAKEPSSQYNMFHNKDSKTREISDTKSTLLSNIPVKNSTFIPPNPEINNVANLSNQNDEISGFLDCKRLVSNLENISKNLQFAITYLNVLNSSVSDETRNTKFDSLNKQAQDLSIDVKCKNFYISTLTSWNLVIKDPKYQKNHPYLNSLYCFLKESRDSSKRASDYLRKMCYLKLIDSYLKKEINSLNGIKLLGNYDNMTDIDILTIEFLGVTQILCRNRFLAFIKSYREDEGFRKVVDYCNVQFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP07</accession>
    <name>A0A4Q9LP07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2001p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002001">
        <property type="protein sequence ID" value="TBU10129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2001p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020299454" evidence="1">
        <location>
            <begin position="27"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="456" mass="52912" checksum="BE8B1FBE711F9795" modified="2019-07-31" version="1" fragment="single">MCLASYKKIIFFVLWSFIFCSQDTQTNRNLTNTSIESTAKRIYFTRVVLRTDLQAKDRGCGNISVSWQPLGIQITDEINPNEAQRSSYNSSHGINAGVRAHVFDSNVNAFPKSGELMRTSTGVPRHCNHSTDKQSYIKSLKKPLVSKNFPPKEFRKQSSLHQTLQGVFKSVLSFKDDSQSDLPQIHMFLNNQYFLHVFFEQNTEKNYTEFIKNICFIERQLIETQPNFSASFRMIFEEEIDKISIFTKNDEIIARSTFLISLKRFFKERLESIDVSKRCFISVFLAMKSIESILLLTRERLYTDNLRLIKKSNHSIYKTLNDVLDKNSNTIIEIIFVVCSFGLNLNDDYLKILNIMSIGIKRRNVNSIVSKLKSSTNLDIDFITDLGFLFESNEIKKIVRAYNSTASFDRNCLNTETFSQNFSSELEKILNEKNFIIQIIEYYSGIFSDTKLQFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP61</accession>
    <name>A0A4Q9LP61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit of adaptor complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1947p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001947">
        <property type="protein sequence ID" value="TBU10199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP61"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1947p0020"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="1">
        <location>
            <begin position="110"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="44642" checksum="FB5A195445F5AD66" modified="2019-07-31" version="1">MYQDICIVDKNDILIYGVRRIENPTKVIYHDDIKIYISSKCHSIIQNYLANEFIETLASVIGNLNSKTLKSHFFDLLTLKSEINTNNLLENIKNNIDRKIETVKKFTNNESEIMLDVIEELNVIMDIKGNILRNNLNGKISAAKSKKTKNYFYLNLSVPQNLEFINLEDNIDTNSEKMGITENCFRNEIKEYGNNCNDLESKNGSEDKKPVLDPILNNVVHLKQNTYLNANKIFSESKFQTPITLKCSDQCLIRYKSIPPNPPIQLTLEKNYILLSCRMKEINNINIKILLPYNSHSVSSSSENGKATFFEKDSIIIWNVTNIKNESAKLILNYQSFQNQKLRGILIDFECLFFSCTGLTIKDVGLKEKTAIWAKYLFKSGRYEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPF9</accession>
    <name>A0A4Q9LPF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1860p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001860">
        <property type="protein sequence ID" value="TBU10309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPF9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1860p0010"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14320" checksum="3E637E1CD2F2A34E" modified="2019-07-31" version="1" fragment="single">MVLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPL3</accession>
    <name>A0A4Q9LPL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1816p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001816">
        <property type="protein sequence ID" value="TBU10369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1816p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="450" mass="51150" checksum="FF293E88579F786B" modified="2019-07-31" version="1" fragment="single">QKESGTSGKKIARWNFKRLKYLLPWYNRNTSRTRRYIRKNFPVSSENRSISLGLNKIEHNSSISVNSDSDEIKFKVISDSNSNRKRIVKSTPLPKGVEQNSLIFSDSNSNALTSQIDSDQSSCIDRSMVTETEQISIDSRDKTDNERNSFLEPKDIRIRAQAICINKAKRSLFPEEKTKSCNFMRPRALDIDKPGFGEYMRSFYGKEYTNNSDNSSPKKMRFLQKKLSSSSKNASDNISMKHNSGVFTINSNISSNDRFYQTRLPQGTLESNNASDSNSIPKNSSDNDSISKNSSDNDSIASIQSNIFDLNDEITKNIYPKTSSPKTKGSHNNLPSLYFTRVKHADKAYGDESNLLEGAVDYDCTNKKKSSKNLLQPLKTGNNCTRVNGEIIQHCSQDTGNNHFKSAYQCTNPDCQKFFLESMKFITKFRGKIQEMRDEIRDSDYKTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ30</accession>
    <name>A0A4Q9LQ30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1742p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001742">
        <property type="protein sequence ID" value="TBU10464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1742p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020479484" evidence="2">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="24262" checksum="D3A0A06CF821B79C" modified="2019-07-31" version="1">MEIFYLYLYIVVAVCGIKTNENKSGNSTENVEILFGFGTDGYIVSQEERHRQINHPRFNDMCIITFLSEANPVVLVDQYKKYRFLEAEKNHTDLYESSDNYTEINQSSKNHTAKINSSKNNSDKIQSSRNSNKIQSSNNYSKKKNVNESYFDELQQEENHSDEIHFKEDPVYEIQSDEKHSDEIQFKNDDIDEIQSEEYSFDETNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ34</accession>
    <name>A0A4Q9LQ34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1642p0010</name>
        <name evidence="3" type="ORF">CWI38_1695p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001695">
        <property type="protein sequence ID" value="TBU10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001642">
        <property type="protein sequence ID" value="TBU10623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ34"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1642p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1695p0010"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="21287" checksum="866C0511CD0088B7" modified="2019-07-31" version="1">MILAVLSVETTSNKIKREAYDLSSFNYFTRKCVREMIQLTAITLTKKIQNKSFQKIIQEITNGKTITFYIKVYEDLMYVMCVKEEYPEHIALIFLNEASLETKDYKILMAEYQDYKSKDVLMSVNKELEETKYILSDTLESVIGREEMLDDLVKNAENLSQQTKQLFLLSRKQNRCFCSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ63</accession>
    <name>A0A4Q9LQ63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1650p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001650">
        <property type="protein sequence ID" value="TBU10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1650p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="16273" checksum="775A7911EBD57A0C" modified="2019-07-31" version="1" fragment="single">GGSNEYYRGSKGNVLKVGDRDSKGRVGGSNEYYRGSKGNVLKVGDRDSKGRVGGSNEYYRGSKGNVLKVGDRDSKGRVGGSNEYYRGSKGNVLKVGDRDSKGRVGGSNEYYRGSKGNVLKDSKGNVLKELGINNSNSNNSSISNGNSVVIKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL5</accession>
    <name>A0A4Q9LQL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2127p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002127">
        <property type="protein sequence ID" value="TBU09690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2127p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="818" mass="96341" checksum="03E28EA7455A85E3" modified="2019-07-31" version="1">MIEEISIFKDTRDIEETEHIYKLFSENINIISNEIKRILAFINCNTYSEGIGIKDICTKYKGRGDIENEEDCIDLSKFVIKIISVELKRDMEYFFRLLSVQDFSFCNVNILIDIIYWIQILDIPMDFNLYRFFKLLIFNLIDSNEFVKEYINHGDINNVDHNINTAKESPKDKTNTNSINYRFDNNVYNLILLYEFLKNNITDKNILHIMFEFESNTVIEFKNNNLIICNSFIRFTDDILFYVLDLLKVNKFRKIFSYLLNMCQIPEIIFNFINFRSYIDNLNLLIDVLPESIEKISLNDVENTEVLFLHLKSTHSKQNIKRITIFDRKFLLPYVFYLRDFLNIEEIRISSVNKSPNDFDCLNIIDHIFAHLKVLYLSVRWLPDTNFFKIVSDFKSLTDFYLSINIFISYNDFLTVLVNLFYGNFLKSLKICIFKTNITNIFIYLKFFNKLENICLECNETNNSRSFTHISQENSFFQSSNHSSSPPVSEYLKNPSNHSYSQPSTNSSQTLNPLQISSKLNHSEYFSIKKLEFVNLRLNKKEYLFLFKLPNLSKLSLKHCHIQDFDIKTTILTTISSPVNIIQLERTNIPNNFYKILQKCTSITEIHIYETILPTIFLQNTYLINFTNTKIIKIFDCKIFGTHTFISSFPNLEHISINIPLYMSQMSFSQYFHILDPLKILSFSYSNHNISQSDTTLLSHFKNLKSLKIISPNFQHCTLTDIFITDFGHNLQELLLIETQIPQPVLHYIFTLHNLHTINLSLSTIHNTKPLILYTSSCLATLIISGINTTYTSYNYILEIFSPSLIFLDFPINYMPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQS8</accession>
    <name>A0A4Q9LQS8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0780p0010</name>
        <name evidence="10" type="ORF">CWI38_0635p0010</name>
        <name evidence="9" type="ORF">CWI38_0714p0030</name>
        <name evidence="8" type="ORF">CWI38_1521p0010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000780">
        <property type="protein sequence ID" value="TBU01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001521">
        <property type="protein sequence ID" value="TBU10838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000714">
        <property type="protein sequence ID" value="TBU12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000635">
        <property type="protein sequence ID" value="TBU12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQS8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0780p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0635p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0714p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1521p0010"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="48"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="350" mass="40523" checksum="2DB39406143007B4" modified="2019-07-31" version="1">MHRNSKKFNRFSCIEFFTKENPPNTDILINYKESLKEPKIYTQPLRKLTVPGLADDFYSNLVDWSDNYILYAVENRIYLFNYYSSKNTLLYSLNGLMVTSVKFNDKGNTVAIGTSTGILNILDISTQKIQNYQQHKSRIGVIEWDENRIITGSRDRTIKNMDIRIEDSPDVLTFHQQEVCGLKISKNKKFIASGGNDNKLFVYDTRNLNNYFHKYTEHKAAVKAIAWSPIKPSLLLSGGGTADKSIKMWNTMNINNSPVKTVDYNSQICNLYWTRNNTVISTHGYSQNDARISQAPTLRVKKIFYGHKNRVIHFSVSKDEKYFVTGSSDNILTFWKAEENFEHESFSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR37</accession>
    <name>A0A4Q9LR37_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1588p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001588">
        <property type="protein sequence ID" value="TBU10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR37"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1588p0010"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020870652" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24881" checksum="3B9DE9A8188EF912" modified="2019-07-31" version="1">MVMLLIFFTILKFIRNLKKEEMIFNKRNDIYMDISYVNIESKERVTERIIIKLYYDDVPRTCLNFYKFVEGFEVEEEDGKIKNLRYLNSTFHRIIKDFVIQGGDVVRHDGRGSISIYGKQFEDENFMYKHDRVGLLSMANHGPDTNGCQYFITLGKAEWLDGKHVVFGEVLGEYLDVIKRISMVETRGRDNRPTSMVSVVGCGFIKKSGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB0</accession>
    <name>A0A4Q9LRB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1645p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001645">
        <property type="protein sequence ID" value="TBU10616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1645p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020530251" evidence="1">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="549" mass="66177" checksum="A8895885CD01ECEF" modified="2019-07-31" version="1">MRGTLFVVGLISLMIERTTCISYINVGCNTMHILCSVVCSGRSQKKNMLGAKNDNFKDSINDTKIRDCKEKNPYHSPMQRQGKRFCLITTNSMEDSFDFHYIMEPGFRFMKESIFDTIDFLTTEEYIKDINERNKEYLKNKKLDNKFVGKIISNFGSVVKKKMIDFLKNRFSQPINSDKINADFFDDAYLVFKEEIKRFIVEFKRDNEIDLKEAACRDNAKEKIISNILEVMKSKFFLYDCVEKLVYKFYQSLYLKFQKEIYFRFFGKTKEECIEIEKEKNKIYKRLQIMKEKLQFDTELDNIFVPFSIREKHLNFTSFFSLLCEFCAEVRINFKKAKKNKRIFFVTILTDEFQLFKPEFLFAQNSLYFYNFYFDNIKDLFQKYGGENVNFHIIHMSFIDLKDFLFEFLVNYSDDFIYSQNRLSFTEIIHKERESISDFTKSLIQQMSPCCRLWFSFLLEIYRLYLRTEYFKCELTIFAFEISLVSFQEIYNDFLEKLETNKKMFLIGQEEMEACRDFFLKCVLFRIKHLTEKFDKRSILSIDFEIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF4</accession>
    <name>A0A4Q9LRF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2026p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002026">
        <property type="protein sequence ID" value="TBU10095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2026p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="29417" checksum="35C0F1F87DB9CE0E" modified="2019-07-31" version="1" fragment="single">MNLSASVCSIDIYTSFIICGVLLSKTRYIYSLDVNFPNEIELEINNSNKLLKKRNQLGKGTYGHVYHYTERIEMAIKGQSLDGQCFEEELELCQKLSHPNIIHVLFSFKMNKSGYIAFEYFPRTLFSILNEEKICLRDLKIIFKQLLDALLYLEGEGVIHNDIKLDNVVVDSDLNAKLIDFGLACYVNRPRRIFSPQNPVSEERKNLFPYFSPEVLKGLDQGFKSDIYSWGFMLRNAASGILFINPGDFHTDVTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT5</accession>
    <name>A0A4Q9LRT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1300p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001300">
        <property type="protein sequence ID" value="TBU11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1300p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="35258" checksum="4237D593315008A0" modified="2019-07-31" version="1" fragment="single">MKFYVPALMVLFFQSYDGFYDKFFHLGKNDKMKTTTDKDHKDKVVIFESNNRAFNKEIFEDISNSRIILKDYIKIYYLEVESDIFLETLFSKVENAITDNNLNNNGFEIEKYEFTIIKTIFDEIFNLFEKDINSIGIEYREECEEIVSELKEFLTMKFKAKMDKNPISSLVKNKPIGKISIDSDEIKFKLSVYFKTFILNYLKNLFTYFGNFKTFAQEVILKNHSISYYYKTSEFKKLNYIFTCLKYETLDIDTLSINFLFNCNNMNRLEEIIKVAYAEISNNCNDLMTEKSQVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ7</accession>
    <name>A0A4Q9LRZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1505p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001505">
        <property type="protein sequence ID" value="TBU10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1505p0020"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="20890" checksum="4B5E6F620455CD69" modified="2019-07-31" version="1">MEKEISKEEVELYDRQIRIFGFETQKKLLNFTVLILDQENKNRFIAGEIIKNFVLLGVKKIGYNKYAFDSFEKLSPIKITEINENIICDIVNHQNVRYNDYSLTVFIDLKPEVSVNNCVFICSKCFSFYFLDQEETCKENCGTKESSVANDCLLGAIFVQEAVKKIKGDIYLSKYTLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP4</accession>
    <name>A0A4Q9LSP4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1116p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001116">
        <property type="protein sequence ID" value="TBU11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1116p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="26175" checksum="017B4A45BF11DC27" modified="2019-07-31" version="1" fragment="single">FKSSKRIRSHAVQEILHNEYAEIRVDIRIKTDVKIRNKRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESELNAEESWERASMSVIMRSEMHEEPTPSYKEEKREEDGVKILKPKNNTPFISQGESTLEEPTINIKKMVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT54</accession>
    <name>A0A4Q9LT54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1265p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001265">
        <property type="protein sequence ID" value="TBU11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT54"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1265p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="460"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="936" mass="109351" checksum="179153E64F38D5BF" modified="2019-07-31" version="1">MAMNSIVENSSKNLINLDFIDENTAEIICTENNKQVLINVLTSLSATLLQQSPEIDRNKIFNNKNFKLRMEKILKRKNNQNVKLKKLAVKLTTLEDQKINKINDILNLQKFDILALAETWRDDLIFLNKDYKVVAQKAPVAVQNRSSMTEGMIIVAKKQKIVEILENNIIVVGDYNLVQNQSLEQDVLDNHLQFGLSEIYLHSDTFRQNNRSSTPDKVFSNCPIIVETEEIKDINHSLIIIELPSLTGNVPPKFKINLLKEKIIATKIAKKIQSLTTKHKNLINNLNVEDRCNLLHHIILTATNSLRIRVRKQDRLNPIIQQIRIMRDEARENNNVDLYKELRRDIKRLKKRFNTLDVPLEKILKFHGTEQPKTNQNYKELLDTFILDGNLQDIEQTKEEISDFFKNTLKERYLNMTNIIKGITDNEVIKVIKTLKTGKNEFLKICPANFIHELTTLYNMIILTKEIPSVWKRHRIQPIPKDKGEFRPISLIEKTRKLFEKLIFLNFIPKLHKQQAGFRPQYSTLNHALTIDTLLRHSNGELTCVTLDIKKAYDCVDRKFLYKKLIINQNFSLHDTILIASLIENNEYTISSEKDFNTYKTAPLGLPQGSIISPTLFNIFIDDIIDYVPETLRDSVFMYADDIIICNNNLKNIQEILKGVLTHADENNYKLNPKKCFYNAAKAHEIIIYDTIITKQNPLKYLGYYFNNRCADVNMTIKIIRQKMTKAAAITNKSMLRNIYTSNDKLYQLKLRAYIAYVRPHIDYHAVLLGCNKTFNQAADRIQKGILKYLFKIYYKTPSKIIYALFPVENITQRAEKLRYAAAIRFSTNTDTIIGKFYARFESKNMLNYKIIVIAVESRYPDDNFKMRYEKLKKENLKLNLLIFDRIPQLKSYNFKIQTRMSFGIFLEIIRPVHKRDEMDEIINLFSAVEITQYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP1</accession>
    <name>A0A4Q9LTP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1469p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001469">
        <property type="protein sequence ID" value="TBU10930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1469p0010"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="302" mass="34419" checksum="6AED38EA73F6269E" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQKEKIIKAANRASEVDGVIRECKNDQGIPQPSSYTPSTIINNISIPPSEANTNTKVCLLNTIHSPSNPMHSSTVTPRPDIAAGWPNLCTIPISERLVVLRSILRSIEAERQEFIRCVLFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDATRFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDSTVLDLINRIVGEYADSHVPMTITDVARIIQTAQVCYDDETRKERPRSAWKESIESKISVLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU48</accession>
    <name>A0A4Q9LU48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1013p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001013">
        <property type="protein sequence ID" value="TBU11847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU48"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1013p0020"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14557" checksum="1AB15492DD93DC19" modified="2019-07-31" version="1">MRAGICVYSGHSIPKGKGLLRVGLDGKQIFLRNKKVLSFVTRKISPRSVRWTQACRIQHKKGLSRKTGGVRSVVRPMKIIRGFDNVPSALVKKEKEVKEEGSDVRREKIQKVSGDRKVYRSSNLGRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU60</accession>
    <name>A0A4Q9LU60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0910p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000910">
        <property type="protein sequence ID" value="TBU12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0910p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="165" mass="20212" checksum="CCA2597CD78541EC" modified="2019-07-31" version="1" fragment="single">MKLYNINECLENNQENIQNRRKMYWKTKEALRRADRTKIDLKNIEMIELLLNIEKNVYFKEERQLETYPEFMQRCKSNFLKDFICCNNIFTDFDTYVMHVQKYHQTEIEAENQSSINNYENFQLLNYDFSNFQIPELNLLNEKPYFGIKKPYPCKVKGCYKSYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC6</accession>
    <name>A0A4Q9LUC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0876p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000876">
        <property type="protein sequence ID" value="TBU12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0876p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="490" mass="58440" checksum="828CD7661BBDAFA7" modified="2019-07-31" version="1">MKIICSSLPKNFEKIIFVIVEELLPIFDYLLNNEYFTSKDNVKFIIYDNPEYFIDKIFYFKSIKKLTLEINQVYIEHIIKVENLTIYDKIESLKFILYSFSSLIFQNSVFSLSGRNKKFVIDLENTVYISDLENQLKFFQTYNFQNYLTKVNLCLFREKYDTTYFAKIFNFNLIKFLKIDLKNVQNNFLVSYKFLESFEALRGLSFENIKLTNKLFEVILCSRKLTTVLFDNFMVFDENELINQNLFNNSILFLGFYNLNMSLNSLFFLYLSKFAGLKRIILNLHHNQSLDTNEYCFNDEVRYLNIPKPKNHRYLPSLESLKYGNFFFAKNQTSSSILKILYNLFNLENLIELKYNTGCLYKEDIEIFSNLKSLKYLKLSIQNKSSDVEILRKILRLNISNKIFKLDIYAYKFEISEILSISNFKKLKILKLTFDSDEIIIRKNLGILYRMNFIKLDIYKFEINPLLDSYGYAKKIIFSSSLLNQSHIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG8</accession>
    <name>A0A4Q9LUG8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1298p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001298">
        <property type="protein sequence ID" value="TBU11255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1298p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24132" checksum="C0DB96363C72875F" modified="2019-07-31" version="1" fragment="single">LTHLEIEKILNFSRLENLKLHTCNLDSSHLLNLNKLISKKILRRLILTNNKIKNIPITCKGMFNDLEHIVLDRCGLYAGSVSLFFNDTKSNKISFLDLSHNSLNRTDLIVVSGLIKLQVLKLNGINLQEDARLNNLTTHGLTKHLKFLEIKELTISAKDILFLSKFKVLEKISLSESSFKCLKITKVRICCSNFDVDSVLEIETLSNKEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS7</accession>
    <name>A0A4Q9LUS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0762p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000762">
        <property type="protein sequence ID" value="TBU12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0762p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="470" mass="55692" checksum="5C33AEA163511F4F" modified="2019-07-31" version="1">MQNSCSYYYISHEHYNISQSYPQPSLIFSHNLIVQNPVDLYGSDNYSYLFAHGSTLIQNEIQNPYLPVTPIPSQVYPTIDSFFYLQQNENVPMTPQSSYKKLKKTFEAVLLFTSDSDSNLPAIEIFLDNNYLLYELFKINSKKSYLKFIRNIFIIENRLNENRFNFSRNTWEVFVNELNNIDIFAKSNEMLLRNTFLILLKNFVKDKLQSMPLKKRCGIFMFMAMKSIESILILTKREKEIALERRGADTINSIFTNINSILRNNSNIMMEIIVEIFNLGFYLNENFFLVLNITKIGINLRSRNSFVTRFNSTRSFSIEFITDLIFQFDSEEITKIASLFNLSNTTSNQFTNMNMCNPENFLALEKLMSEKYFVIKTIRYYFSIFQDAKSKFLDTNIAHRFVREQYHSLITRFKALISENCPNVEQDLHELRLDTYYFFHFVLNYCHNHSESSEKYLKALREPYSRQIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV3</accession>
    <name>A0A4Q9LUV3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0883p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000883">
        <property type="protein sequence ID" value="TBU12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0883p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="59541" checksum="BAF1A66310A757F6" modified="2019-07-31" version="1">MTDISGSNVFNMTNEVFIKYRKYFFPFLIVLYDSTNLFFNSNTKELLFMVKRTNNKCDLVGINSTKEIAIRITPTALSLIEEDNIKDKKKLLFRLVNSYKIDGIKISSDNNYFVESRNLDIKFEFANDNSDIYEMKASFCSVFCTPKSLRKNEIKSIEFERIFLSVLDISFLYELINLESLILVKCEFIDSNNFFLRLSSNFQNLKVLRIINFNIQNGFFNNLRLKNLEILDLSYCKYKGNCGQLNLEKIKLTKEFIVENSLLNYKIMDSIIINNHLDVLSMKGINFTAVKFFGNCANWNKSFRLLDLSGCLLANKFVDFFSTNLKCEMLFLETLYGYKHLNRILSQNSLHTSTWILSISGNVLNSETLTNLYKFERLEYLNLSNMPRLDIKGFDFEPCKFKSHLIAINLSKNNLNKECLASIGHFNRLESLNLSECNLEAGFIESLCCNNLLVSLKRMNLTRNKLIRSDMETIEAFVNLIFIIISSDSEEFSDFFINYGRLKCPKLRISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX0</accession>
    <name>A0A4Q9LUX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1218p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001218">
        <property type="protein sequence ID" value="TBU11415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1218p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="669" mass="72654" checksum="97067AF9BDDE9D5A" modified="2019-07-31" version="1">MLEIECRKKCRRSSSESDCFSDSKSSCSSSSKSCISWSDHHEDRRQNSFVNCDSRRKCEPCFPPPKKCFLPKPHKSHKPSPPCPPKPSPPCPPKPCPPCPPYPECPPCPPCPPCPPCPPIPACPTCPPIPACPPCPRCPACPPIPACPPIPACPPIPECPPCPPYPECPPCPPWPCPRPPRPSPRPCPPWPCPPWPCPPWPCPPWPCPRPPRPSPRPSPRPSPRPSPPCPQWPCPPWPCPPCPPRPSPPCPQWPCPPCPPWPCPPRPSPRPSPPCPQKPCRVLRTIDGIIDCAKAKSKCAVSEASCRLQEHIVQIVLRGSGKIVHKINEEFDDVVDCLKFKLSNEAVAITSGALTCGNCNSGAKFDKKKGDSGHESPDETDAKVLNIVKRNSKILKNGIRNIINAESVKLTSGLKNDLAKMSSSEKEEALKSDGYKNIISSAVKNTLSNITASTNDLFENVIQKEKAELTRLYKNSAADNNIPGNLRDKPVSPVSPVSPVSPVSPVSPVSPVSPVSPVSPVSPVSPVSPVSPVSPGGGGNQGNNAFPNSSATAKGCSGALTCAKIIPGHRHAVIGLIESLRRKILCKIDHVIRCEIGQIKCAFKIYKFFLDRKLDRIIWKAGHEIKESVKDAFEEYCCKVRLAPPSPRFEIQDTKEENSPAFEKLVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV39</accession>
    <name>A0A4Q9LV39_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0888p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000888">
        <property type="protein sequence ID" value="TBU12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV39"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0888p0040"/>
    <dbReference type="OrthoDB" id="3691720at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="240"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="517" mass="59381" checksum="0E45551A99F93201" modified="2019-07-31" version="1" fragment="single">MTALNNSNNEKKCFFLDEPRGSGKTYFYKALYYAIKRSGRTIIVALSEIAANLLHKGRTYHSRFKVPLILKETSVCEIHDSSLIIWDEAILATAFALQSKDRLLKDIQCKSRLSFDGKVIILDRGYRQCMPVIPGAQASDFVHASINEWLIKLGNRQLMNTDCLEKTLIEISSHMISKDIVKDIFGEILFVNTVCKFSKKVILTHTNEEVNKINQSKKTYLSTDSLNSDDTGDVTDHSFEFLNFLTPSGTLPHALYLKKGAITMLLRNLNTERGFCNGTRLIVYYIFLPRIDLKSDAGQPFQLKRRQFLIRLAFAMKINKAPGRTLDKISIFLPTPVFVYIKDTAEQGKILPGSDKIFTKNVVYKAVLENCAYIKEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV59</accession>
    <name>A0A4Q9LV59_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0625p0030</name>
        <name evidence="11" type="ORF">CWI38_0706p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000625">
        <property type="protein sequence ID" value="TBU01800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000706">
        <property type="protein sequence ID" value="TBU12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV59"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0625p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0706p0020"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU01800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="151" mass="17571" checksum="02B7BE53415B149A" modified="2019-07-31" version="1">MDFTSELIFQIESILKEGKSVKPRDLTKIKAITDNPISKLLISLYTKDGELNFAGMVSELQNFVSKSPLDSKLFLIFRIYDTDKDGKISKKDLTTMLKILSNDNIEENKINDIVEKTFKFEVNDSEFIEFQEFCKIIKSRNNNLHLFFRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH3</accession>
    <name>A0A4Q9LVH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0825p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000825">
        <property type="protein sequence ID" value="TBU12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0825p0030"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="8">
        <location>
            <begin position="508"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="715" mass="83399" checksum="7AB7175D25427989" modified="2019-07-31" version="1">MANDSNKEKEPSNKEKNEKSKDEKKSNDTKDKDGDVKNQDKEDKNEEVKEEDVIQDSMEEDSKEGNVENPEAVKEEENLDDVTSAKADNVIEDIMAQEEHNEMEKQEELHKKFKKREILKQKTYSIGNIDEYFHEKYSNINIIFRYAIEMAIVLILFMSWSILLSLICRDPNTYPIFKTLTSDKKINETAEFIRESFFVSLVYIIFVSVTLFIDNLLYIVVYFLTIFGVEVVGIVAELLHILRRSRHHLKNSIVAYLVFVMANFVLANYKFFAQKKDFTYIFLTGIFWFGCLSAILFAESFLMNILTSELRNKSFKGRIWDANYKTFIFKKLAAIAEATPYGKHNVNVIISKMNVDYDTGFYLKHNELDLSEPGAVVESILGYLEVDQLESEDIKRFFPNNSDEVINYLYGSVPESECVSISYEVLKKRAEDLYQERTDIMRSLYDRDNILRKLNLILTTLGFSLSIIIFMILLNLNYKVYLASIGPFIFGFGWIFQDSIKEIYRCFVFLLINHPFDCGDRIILDNEELTVLRIDLLYSTFVNINGRVTYIPNGAMFLKKIDNVRRSDLQAEDIIIRVDISTKYSQIIELKTQVAEYLNKNAKDFTGKIFLKNCEPEETNLKIILSIEHNSNFQDPFPKYVRREGFIENLEKCVIMRSEMHEEPTPPLREEKREEDGEKKNFKPKNKALFISQGGTTLEEPTNNINEESYLEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN8</accession>
    <name>A0A4Q9LVN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0634p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000634">
        <property type="protein sequence ID" value="TBU12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0634p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="80" mass="9667" checksum="AF49E7D133049F04" modified="2019-07-31" version="1" fragment="single">YSIYDPLRRRVEYDCIQHNNIYSNKSKLALGDMVYVKKYLSTKLDKKYVGRKKVVWISKKGYWVRLDGDKHFTHIKNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVU3</accession>
    <name>A0A4Q9LVU3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0610p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000610">
        <property type="protein sequence ID" value="TBU12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0610p0050"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14808" checksum="EC1D8BA1B4BF0041" modified="2019-07-31" version="1">MIIDNVIPAIKSKFPPAYKKKTIYVQQDNAKPHFSDNDADIVALGSADDWNIKFKAQPANSPDLNVLDLGFFNSIQSLQHEASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGEDAIKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX2</accession>
    <name>A0A4Q9LVX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0596p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000596">
        <property type="protein sequence ID" value="TBU12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0596p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30098" checksum="BA265FB1CF2557F6" modified="2019-07-31" version="1">MSTEYKIGFPLNCLHLVKKIYSGTEKTILLIFINSISVYMMVLGVSTLFVSLSFLLNLYLFTEFRNLIIFIENSKNAKRLILKIVSLSIFTNYIESVKNHSIGFWISIFVLSFCISYMCLRIKKLILILSYLILISLIYKNFNFFDDIEFLETSMLLIIGVLGYFLYIYVYRYILALVFAVVGTVLSFVTFEELFVIAENSYEKFFEQFFSFTLEKIHNRMLISFVFTVILSYILQIVFYIMFIPSKKIDVADSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB1</accession>
    <name>A0A4Q9LWB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0558p0010</name>
        <name evidence="2" type="ORF">CWI38_1918p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001918">
        <property type="protein sequence ID" value="TBU10242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000558">
        <property type="protein sequence ID" value="TBU13018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0558p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1918p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="31139" checksum="19C778F305E9F5EC" modified="2019-07-31" version="1">MESRGMNGSKLLIFKFNIINCSLIVALLGNLKKSFNTPFEYFFEICFLVFSIFLMTIGAKYSAVSLTGLLILILNGYFFNFYNKLQNTVKENEKLLNFIRPEFCEKIVKLIEENPKVVWIILFVVCLIIAVLLNFVFKMNHYVIFGILTIVAYREIFHKKALIKFFIEKNYIRWILFIPFVIFAWYLSASVPILLLSIICCYFGSLLFLSTLELLLNREWGFKNAILNFNIDQVSVIGWRLSIIWFILFILALSFQVSTNISKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD9</accession>
    <name>A0A4Q9LWD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0547p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000547">
        <property type="protein sequence ID" value="TBU13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0547p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="575" mass="69244" checksum="AD4801762C3245B6" modified="2019-07-31" version="1">MKLILKLWLGHLSDNFQERDRFEINEYSNTFSSESLFLIDEEEYNDPNLESGFENYSYTYDEDFSTSEIEKYNVDYSENSVQPNNTSSDNTLQKGKTSITNKCILKNVLEGKVEYVQVSNKQSHNYYSKSDLTHKIPQENENRKENTVCGEDIEKSKNIRFLQKNEHNQKKRKDTLLNLNVKQNLNKRHKFPPISDSDKIKAIRNIGYLHETIEEIISKNTCEDISSNFLRFAEERCFENLLSQKIHSMQNKRIKRHEDLIPYFEFAKKIICFEKKNMKNLSNEQMNNFLRELDLRKFEENISNLKKYRILNEIYFFIYSYNKGSIVVKKNHVVYVSFMFKLLEIWHSNLVDFVGLKNIFCFKYNSFVFSLRFIFYNLLFGIENFDSRKHFYIIIGSLIYFNDIGGIKRLRHKKKIYCLQLNILCQCVFLRDFNNKYATSAIEFYKSNVMSSSESSFSNQKYFFKKFFLNLKDMDLIRQYIGTYNLMKKISNFSKIYSDFNEDLIKISTNYDNKEKIEIENEEFIEVLFRLETMIKWTHSKIIYSHHKLRDNFYLERSRKILKYVHYLLMKLFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT7</accession>
    <name>A0A4Q9LWT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0517p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000517">
        <property type="protein sequence ID" value="TBU13144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0517p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="496" mass="58758" checksum="979105CE9FDF72DB" modified="2019-07-31" version="1">MNFKTAIFHTIPSKNTELRHFLSQILDSVDKVIFYKLSIDKKPISFLNKENCFNNLTTVYFFLPELQSNILSFINYLLNISEIFIEFDECFEESEYKKTNMNYQVVIKVVRYRLNRLVILENFEFLDIKNYILNSVFEIKSINDFEEQFRFLNKIFELHNVRVFLYGIIPLATINIIETYIWCTSINLILDFKNEIYSFQIIPFENVKTLKIRNTLINTDFIGCILNIPGLENLYLFDCGITEYNETVSYPKNDSITSLNLYGKEMISIGFIYKFLSSMINLENLALFNDNLSVLLDSDQKCKFSAKIELKVLEFCCSFKNSKCDCFFYFPFFVNHEISFEQGFPPGTLKKIFSIPENTNIKKLSYLDNYLDYSDIGALENLKLLENIEWTGNNSKIRFYMLFNITKTYNIKFLDLNEVELVRKDIKFICSLKSLEILNLTICSFKKKCYRMIRRNKLKTLKCFYFENFFSTKNKKIKMHLQEEFPSSILSISLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY8</accession>
    <name>A0A4Q9LWY8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0831p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000831">
        <property type="protein sequence ID" value="TBU12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0831p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="71522" checksum="3CCECC7D3DBEB59C" modified="2019-07-31" version="1">MGLFNNSLMGQYSNEYRKFNYKKFYFGDKLKPVITNLVFTCFLQVYLLGLKDLNIFYFFDQDNNASINNDLFANLVLQFKNKNLASILKYWVEKKSFHFIEHYIARIYIKRIEIGKLTSDISDDRLLIFIEYFLLKIKEIELIIDENNVKILELIKCKKLRFLKTKILSISNINIKDIFILLQFPKLEHIFLKVEVNSDKNHMVFDGRNTSQLRFFKDIFLFSNQKIIDKIFEIFVELLKCKDLKVIIRKEIGLFEVKILRAINFIDSNLEYKKGNHLFDLTDTNIYSKIISLDTIMIKYWNPRYKSFINIFDYQEIQNLNVFRSQLCVFLYTEIISLFKHPKIKKIILNDCTILKSKDKIKTEDFENSALETLKTQNTGFSKHFIRLLSGFINLKTLSLDSFIKKTEDINILKDIKFPKTLGTLDLKNNNFEVLNERVRFQCQNLKIINLSNTDIPKDSLFYLISFKDNIESFYYSHNRIHSSDFNLFCQMTNLSCLFLSHSTFKNITFSDLIVQKHLTTIKVLNLSHTTLYPQDLFKISLIQTLEHLNLFSCRFKNHSKFFFEPNKLPKLIYLNIEINYFTDSEIQSLKETTNQNVLHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX85</accession>
    <name>A0A4Q9LX85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0447p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000447">
        <property type="protein sequence ID" value="TBU13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0447p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020377264" evidence="1">
        <location>
            <begin position="28"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="394" mass="46119" checksum="6AFBB9FE2D2EC170" modified="2019-07-31" version="1">MKINFKKMCMEHSFMFIFLLKCIKLAAFESEDEYLNQILREFGELSVMEENQFISENIHNKSDIALLIFKVKDASFCVPLFIFNKEDADFLNEKPSYAVESKENDSQNLLLKTLIEILTKSDLNIFPEKGTSNLQKNILLDFIIEYINKIDEMFSESGCDIVFVKHTIGSEASEINMKSLSGEFEKKEYFDIKKQEISDFFSDVLNEILLKTLNQYFQFLGLNAVEYYNQQINQAIDMVFGVSISPGNLLEIFKNPKDIFQREEIKNIIEFLYIFVELIPQELFLQINTILEDTYNEFIREEPDKTLEEKKIIAGNHIRDIFCNEILSNKDNPISIVLRQQIACFFSFVTHGTLEHTDEISEIFYESFSNMGFYQNLLHNLMKLYIFAWGVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA1</accession>
    <name>A0A4Q9LXA1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing ubiquitin-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0785p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000785">
        <property type="protein sequence ID" value="TBU12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0785p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1776" mass="211868" checksum="33EA59D9CBF22936" modified="2019-07-31" version="1" fragment="single">MEILRKSLSLKEKNQKVKFFVNSLLKKDDLSDLFSDTDDPFSLSKIGKTCLLQWNTILEKYEGILKAESHKYFHNLFQVKGFEASLKSRLILLFKILIYIMRNTHNHELYIIDSTHANFLYSSDTDISFYSFLFHNEFYNDFTHPHNTMTINYFNSLDFSFFTKKKYEISSEFENDIIDIKFTYKEKFITDFQNEVQKNIQNNVFDVLLPIFYELYSKYSNGSLLCSQIFKYEFYKNSESQKLLSIEILANLLYLKIYSKIQLEIILYSVYFFCTNSLEDCFLDSLSILSTNIFLIAKYHIETEETVFLKNVIEHISLKLDSCSNILQNEIYSWLKTRFYILLNFLNKDFIKKQKPINLFLEMDSKNIFMYICHILYDQSIFIDFMNGFISNNTSQILNDFYFKIFHEDTNYEIKDVFGVYCRNHEDYSEYKILFYQIFAKIINYFAENPHLNEHNGIIYPFCEYFYRFTENISLYNSTSIDQVCKITLAIFSHSGNNNVLFYKFPILKNILKYYFYQSKNDTTVFLIHNIIYLIRLNANYYLFYNDSLFLENFIDMCFKNAEFSVYLLLFPLEKYMMLTYIQIYLNNQNIYIFNLDLLLCHLNDMNTISNVDMNVFLNFKKYSVPFSFTSKYFDFLKSINEYNIVETCSCYDFHYKHVLELSEMILNSVYLKIKYETEIDIYSAIQIEDYHYYCTDVCFLMKINYLILKKLASNLSEKFLISESIHRFISNIEIEILLDLVSLDKTNPNCYKKISKSFVFLKHLEENIEHVYSIEQHISRYECIKRIIGIVTLIYKRMFLSIKLPIISISSDEINIMDLDSKLNVLNNSDMDIISFIFEQNYVLILKLLLRFQKFPRIIPPEDCNKSIGFIYFIHKISSDMVTSDPNLISIYFRYINQNIGILYEYEYTELINLLQILINHSVKYYSTYQIDLQSVKNKILKILRSLVNRINIFNETKIYEFIDLTFEFLEENISLLSLEDFLLFLNELSLSSEKIERIISELKLFSKILVLIAKFDNHCVNDLNNTVNILENPFLHPFLNDLFLNLNFADFFKEAQKDQDSIFFFICEHINLIEDPKVYFDKNASKIDKYLKILRYNIVTNINNNKSMEYKKSSLFLPNLNVDYKEESDVFIYLISLVRLSNYSNIISKSEIYTYFDISKVLAFSEIRCKKNPENKDLILDCAYTYLIYLFEDELYLVSSFIYVIHFYDHLPSNITEYFNQKFIYTPKIQKKDSIYSNPIKDDDIKLKATILHDIINILKQEVYFYKIFALQFLSELIATFPSLLNIIKNDIHKDFINRLEFTYLLGIEFGRSNCRDWDLCFRFGYFITVSLYRGSLNYAKEMIEKICSVLNESNQHRSINIISLIYKILASEICCCKYIQYLNIINPKFYDKNCKTNCEKRKNEIFKIFLSNNILNILLLKGKEIYNEEIFRSNYINVLTDLWDAFFEYIKNGKIKIDKKYLICCLFQFYVPNSSDILFPKCLIKYKNLKIGSIKISSKSEFQTFEKLNLKRLSKIKTVDFGYVLKCDHEIWNSRDYECIKFFDPKLKSSNNFYAVNINGIETIAIDFKSKSFQNNQIIDRLKRKLKLYDLPEEVYKVINSKLFLKEATLDINIGCDHHNDIFNLDNIMSDIYANVLLNTNLVDKKEYVEPQLSIVEGNFDENVVLKGLIFLCIFSKPEDFIEMIEIIKKILDTYSNLECLERYIESIAHEIEDTKLNEGNEIYFGKLEGFKKIATFFMSNKYFIKEDLLFELLFLELFFFDENERYFSGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL8</accession>
    <name>A0A4Q9LXL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Leucine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0522p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000522">
        <property type="protein sequence ID" value="TBU13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0522p0010"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="185"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="634" mass="74338" checksum="CCA39492908B0B37" modified="2019-07-31" version="1" fragment="single">IIKECEDRLFLLENERKEISEISDNKTEISLNFTENLLRFYEPESEVISRSNVRCVVSLLDQYFIDYGNMDLKNKTKKCIEKMIFTKETKEMLIGGLDWINKWGCSRTFGLGTFIPWDNRYLIDSLSDSTIYMIFYTFKHFLFTDLEGKEEIFPVKFLNDSIWNFIIYNGSLEDILKNNSAEIKNYISILSECKKSFEYFYPLDLRVSGKDLIKNHLIFFLMNHCALFPEKYWPKRIFTNGHLMLNSEKMSKSTGNFLTVDDCISKYGVSASRMCLAICGDFNEDANFVESNANAFILKIFNFIVQIENLKDKISYFLSNCKNKNLEEIKDFEEKKLEEIKENKNSEEITERFVKISINANKENPDNGDIEYLNSAQFIKSILSTLSVSSLTYQEKFLLQSLNNFINLVDSNYSDMAYRDVVKYGFYEILNLKETFISLGGNSDSDLIILLYLCILLLIYPLIPSLSISLLSKFFKINRFSFPSIIFENKLSQKDEIKNISGIIQDKDSIIGIEYLKKIIKNIKFKASKVNKKNKKIKTVRLSIFNENSLEFWRNEIYAVRNKEDICLFLSKNDKNDIKHNLWADECFKWIEVNEIFVVKEFSKYIENKCGYSVRIVLGDKGIPYEPFIEFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ5</accession>
    <name>A0A4Q9LXQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit Rpc34 of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0168p0060</name>
        <name evidence="9" type="ORF">CWI38_0382p0060</name>
        <name evidence="8" type="ORF">CWI38_0512p0010</name>
        <name evidence="7" type="ORF">CWI38_0898p0040</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000168">
        <property type="protein sequence ID" value="TBU04219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000898">
        <property type="protein sequence ID" value="TBU12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000512">
        <property type="protein sequence ID" value="TBU13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0168p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0512p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0898p0040"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU04219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="234" mass="27088" checksum="935A976CB300D55F" modified="2019-07-31" version="1">MKNLLEFIATAEDGLTETDILAGYPNATQEEIAKNLNILLKKKQIDIFNDGHTLKYKASLSTMKDEEKMIHTLILESGTKGCLVRDIKNKTNIPQNFVMKILKILESKKLIKAIKSVKSNLKFYISYDQNPSEELTGGIWFNEADIDEEFVIELTKLMYVYLSKKTLWNNQFSLSKIEEFPCLETIHDHIEKTGISNVGLSLENLYTLLQVMIYDEKVEKIFYKDKYVYRALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR0</accession>
    <name>A0A4Q9LXR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0726p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000726">
        <property type="protein sequence ID" value="TBU12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0726p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="29596" checksum="047B458D2AB0D611" modified="2019-07-31" version="1" fragment="single">QDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEESTNNINEESDLEEETTVVKQPSKEEVAGLKLLAVLNSLKKITVKIENVSNVIIEYTDKRVEYEKAVVKAIVMNKEDMKTPVAYIISGIAKNVVIKEEKTDYRNTYSSLIEDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT0</accession>
    <name>A0A4Q9LXT0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0168p0080</name>
        <name evidence="5" type="ORF">CWI38_0382p0080</name>
        <name evidence="4" type="ORF">CWI38_0898p0020</name>
        <name evidence="3" type="ORF">CWI38_1051p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000168">
        <property type="protein sequence ID" value="TBU04221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001051">
        <property type="protein sequence ID" value="TBU11758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000898">
        <property type="protein sequence ID" value="TBU12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0168p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0898p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1051p0020"/>
    <dbReference type="OrthoDB" id="10252174at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17000" checksum="03CF2F6975B5830A" modified="2019-07-31" version="1">MPGIAYELGNPLFMRTSIKEKINSIQALIDKMENKKNFSLIEILKEEIIKLKNLNDQYKSYIDTKKVVHTDSLKNKTRYHLKDGSTYVVNKNGKYRYLYDASTKIITYEFSNGQIEKTFPGGIKEIRYPDGTITIRNGEKDYDCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV6</accession>
    <name>A0A4Q9LXV6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0500p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0020"/>
    <dbReference type="OrthoDB" id="6744471at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20776" checksum="F70F2552B5499971" modified="2019-07-31" version="1">MDTKCFKDQGLTWIHSVEEILDNEDAEIRVDTRIKTDVKIRNNRPDIFILDTKKNTITHIEEGITSQDSLQIVETEKLRKYDLLANELGLISKCSVKIIPYVITWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMYVIMRAEMQEKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY15</accession>
    <name>A0A4Q9LY15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0505p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000505">
        <property type="protein sequence ID" value="TBU13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0505p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="748" mass="89187" checksum="370BAD66E06D55A0" modified="2019-07-31" version="1">MFFSIQNTDDRIDYIESEEEEVFEFKIQSKYILDTFTSVYLLKNTYLKCIMRNGSRKYFIPQISKIFDSEDIILSLSIIEDEQNDSPTNKYFLGQISNDFLLRFTKYVTKEDFFVNTISFIDLINFLRVLEILGFQRTKNNTDFLKHLLVKSLIDENFNFKSYKKLLDSTEQNMNIYNLNFEYFFSVFLHFVFIKKTKNYTFLFFKSNNSMHDHKIILSYKAYIWYRERFYNENVFILESETILHLDKILSLKWAIDCILFFIRSCKIDMFWFAVTENLPSEKIFNLISSIKPKNIKKLIIKDDLMGKNTFKCVLANAYFDTASHVKISCNLNIEEIRNVLVNSKNIKKLEIGSDDAHSDILAELNKYALSHKNIYLKYKCYTFVMDCNRYSFLKNMPENFIFYVQKFHDSFLHCDFCHLQSSKLFRKIITRLNRDTSLKEYKKMFSNCLNVKEAYISTVNNELMEFRHLELIKYIFQIPNLESISFENVICIKILIRYILESKKLISLKFYNSSFLSESFDKCNIKNFTLRGITIKKSRFCLNGDFIKFLSSFEKLIFLKIYIKDIDSGFKKLIVESASNHPKEKFNSKLDYLKITLNENIAKDLPILSVFSYFFEISNLKVLILQINKIEEQDASVISNMKYLKEMHLTVYQNKNKIFLQRLTKILENKTIKLIKIEVKYLDINILNIFNIFIYFEEIETEELYSIYKMKLNYSSSITLNCKNDQPLSPDAINFCNEYNIEFSEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY77</accession>
    <name>A0A4Q9LY77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0600p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000600">
        <property type="protein sequence ID" value="TBU12871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0600p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="616" mass="74235" checksum="141B017D7A74BA4D" modified="2019-07-31" version="1" fragment="single">MSEEFYLSKSKKLFVRKLSRYKFIIFIGFFWSVYSTSVSFFVINEENCITDSNIDNSILEATESENYSVECIYEQEEIKVLKNNTICREYTPNQFKYYNPNIFTMPYRKNMLLNSNFLKTAFESKQTNIRIFFRDISYNALLLFFKLIDKYDIIVNQIKTQDFLDILLILSVLDIERTKESNHFIKELFSNFIFEMQNSNHVFDPQKYYNSYHYKYIKKSILIELYIILIDLISFNDKIGHRYTVHHETIASNFKKTITAYSFNNMHPKSLTSQIYLRLNNISISSLHKIINSEYLMNTWIFLLNITKMDLIYFIFSDEETYNKSIKVFSNITLHAEKLYIHFFQEPMKFFIKKNVNFFSENLKVLKLRYNFTTEELKNILRFCNRIERLTIKTYYIDFERLSLLVNFSMNNPNISCKILGFVYELPDIDYEFINNIPRNILFYFENSNRNVEYEEIPAKYMPFFQNYYFHYKQILNSRITIKPELLEFFRVKSVTLDFESNSSPYKIETSVFNMLRCFKTIKYFSLQNIVISNELLLYVLESDTIKILTITKFICIDKFRYISENETLFNRKLVDFLLFDSLTEINPSIFIYLSRFKNVSGFNFTIINENRTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY78</accession>
    <name>A0A4Q9LY78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0335p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000335">
        <property type="protein sequence ID" value="TBU13811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0335p0060"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="19556" checksum="63180C7FC62947AF" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLTSPNAPVPSSVEVSACEPSYDMTSPCTLAILEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY83</accession>
    <name>A0A4Q9LY83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0354p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000354">
        <property type="protein sequence ID" value="TBU13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0354p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1579" mass="184584" checksum="A4601631BC7CDE3B" modified="2019-07-31" version="1">MNFMWRRGFLSGVYKDVSKLSEPRSMKAILGYTVLVCALYVFKFFLYAKSCMNMNNFVIEKISYDFEKSNLIRFDARIKNSKMPISCSVTEISVDVYLDNCDQKIVTLKMKDCFLAKECEIKYKDFIVLERENNFDFKKITSWSENKGGLIFDVSNVFKRKILFWNFKYKIQRKVPLKIFGDENFEPFDVKSIKVLQTKDCLILAPNFCVLTFPSFLEMRIPSFEFAVLANEIPIFKIKLRNSGIKSEKIINCSLIFDREYLENLKSFITSTIDGNGFTLGFGNFSYMNHHSHTLLYLENFLKAFKLKNQSKKEIFFTNNVPFTQLCVKSVNTESITGTLEIHSTFLDNFLDSKHIINKIEIPETFFDVDVGETNVGNLVAKNIKKPEYLQFEIILYPKDLNLFFNTFIMPEDSTLRIHSKQVSFIGEIISNVNFLWDFRTNIGLNKINFTEDFHDGNGMKPNLFQMKMECLNDDKRITEWEMNLLLPEILNNRERVKLKWCDLNLNFTVAEFNFDFFISSNEVIFIKDFRSKSEICRGNSPLNIHLKLENTVNYQGCTLMYSTKQFIKKYQNLKENKFKKNRIRNFFRSRRNNQHNDYYRDSSFEGIFINFLEHIKPKLCFYNTETENLSLINSYFDKILSEKHIKFFGIESIFCEEPNFNLEKIMKKAKFKFNDLESLTKASFLVTLLGKIEQFTDYNIKFEIIFKELNFLICDNSLEETSNKPQTHDINNNILANQFNSLRITIPSLILSFNISDSKLNNLKFVDEKNENSFLTFFEIFLNEKDIFIPEKISFCSENNFNYFSNFLSKIIGCFEFIRPKSSQINFVKRNLDPITSFTEENMYVCLHVIYNSLDNVNPLHPSFGLTNKCVFKGTFFIVLPEDSITERNKATQNEFGFKWPGFEFSVYDENEISDISKVIVSPGSIILRKEGDENKSVQKMRKFTISFEIYSKIYEGNNFILSFKKMDSSFEKFRTKISKNKIKTLTNLLLKGRDATFSSENEDLGFSKYFKELKEILINFLNDETIDINLKNSICDTKIKVESAGDTNLDCVYKNMKVYNYFLRNQISKRLAVLLSKISLEKYSKNIIFNVHAELLKPLDLNLGFLQKKIKDGKLRIGVIQNIDYDSLQSSDEEFVTAREESGISNESFVTAREESGISNESFVTAREESGISNESFVTAREESSQDFVTIREESNKSFATSNEGSQSFVTAREGSQSFVTARDESQSFVTARDENQSFVTAREDNELSNESFVTAREELSSQTIIDDYETIRRTTDNETPRNLIFDRQSLSRNLNIGGSLITNKNSETDIFFTPNSQTDFEEGSSTDSENTPNRPPLNDSFTDEPNLLFSIFIYLHQENNSLKIKIPNENNLDSSNELSYCQSKLLAACSTLLNICKSFNPTFSLDIKKRIRFTHFKNKNILFRIEHEGKTMVESVLNEWETYINHTKLTFKIDPYFFENIMNIQEFKIIIFENKNVIFEQNIEIDQLTKYRLLTFSLKYIFKFIKAYFPKLNRTSFFNGLEYLKNGTVNAFNYTFNKNNWENIKKIGNNVVNSTFYRNKLDYLKSVGNRFLSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA9</accession>
    <name>A0A4Q9LYA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0347p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000347">
        <property type="protein sequence ID" value="TBU13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0347p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13531" checksum="C0CFA5C1FF2E2ABA" modified="2019-07-31" version="1">MTNIVNGSEVFKEIIGFHMHKIVKDICTKKLLEIPLCRFFHCGYNEPKDLTKTETMNRGKKINRIEKSNSNENQKDKFIQFLRDNKSKSRKKSGMEPLYIYFSICKRVLSKFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF8</accession>
    <name>A0A4Q9LYF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0641p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000641">
        <property type="protein sequence ID" value="TBU12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0641p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="481" mass="57508" checksum="C10DF3CE7A4B5E27" modified="2019-07-31" version="1">MKFYVPALMVLFFQSYDGFYDKFFHLGKNDKMKTTTDKDHKDKVVIFESNNRAFNKEIFEDISNSRIILKDYIKIYYLEVESDIFLETLFSKVENAITDNNLNNNGFEIEKYEFTIIKTIFDEIFNLFEKDINSIGIEYREECEEIVSELKEFLTMKFKAKMDKNPISSLVKNKPIGKISIDSDEIKFKLSVYFKTFILNYLKNLFTYFGNFKTFAQEVILKNHSISYYYKTSEFKKLNYIFTCLKYETLDIDTLSINFLFNCNNMNRLEEIIKVAYAEISNNCNDLMTEKIDFSKNFKNIETKFLTLDKKTFPLTKKTIKMYKMLDMVLILDLESIFLEFFGKTYKIIHLIGNRKIFHFKKPFQSLENTDLSKFNRFKQQEKKQIFKIFNKTILKTIREVYFKTVRISISVFIDKSDSFLSIYSKDFYYSNAGSNYSDSQKQIVRFLLSNNFFNGEFLRLTKEYLNFSNKSNIFVYELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ84</accession>
    <name>A0A4Q9LZ84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Sec8 exocyst complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0231p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000231">
        <property type="protein sequence ID" value="TBU18733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0231p0010"/>
    <dbReference type="OrthoDB" id="2193852at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="761" mass="90841" checksum="74DD62870E475A89" modified="2019-07-31" version="1">MDDIPSLIRELRVDWEKTLDEDFNPLPCALALSDSDSQKSATFKDMYHKLDETMTNIIEKNYQGFSDFVLLYGHAFKLNQECYNTLQMIIKDCQIIKNTYSEDFSHLSKEKRELLDQKKILEIYKALDTVKNISNFLNEKIERERFQEASTDFLNIYDLTNEYDLKSLKCYKNLSDDIISLKTSLLNNIFKKIKKTIFSGEEVIENKALLQKEDLEDEYIDTLGCLIRLGELKELDIYFYKNFSNFFFEDMQKIIYSCMESDDKVTCLVKKSVLYILNILKTFEVLISLIKNIDKTNINLIQNQENYFEVEIDDEYHFFGKNGTIKLEDILIIETKKFLEFYSKIKDYDQPESIFSLDNVLDTVDYSSIFQKKYAVSKRMENNSKHDFKISYNKYFSIFKPRPEVLFLFYENIGVEFPKLKENIRIYITEKYIKIKDKELSSKINDIILSEHAFYCDFKNQKLIFFEKLVEIVKKWCNEMKRIGFFDNWNVINQIFVSVLKKYKECFLKIFKCNLIIKSIFKFDSNGNIDENIILERNIRNEINEKEEGIDKLTRFLMIKSIYKEDLIFKKNEYLKILITIDTFNKLYDLYKETIKGFEKNQVIPELEALSHEFEATIKIFILALNFELIVESMYFYIIFFRECTYDDSCNETLQKIFDIFKEIKNAFKIVQINLDILWCLNPILEIFSKYSIRYVRYLNVNNLEDLNVYIEKIELIEEIFYGLGSTTGMTEWLNILKSTQNNKSTNEEEKILIDKISRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG1</accession>
    <name>A0A4Q9LZG1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0218p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000218">
        <property type="protein sequence ID" value="TBU19125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0218p0030"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU19125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="38187" checksum="DC9CDE6977C7346F" modified="2019-07-31" version="1">MTRFNKSKTKKTITKYRQNKKFETIYGTKSLDQIQKDIKNNTTELNENIYYCIECSRNLNTERDFMAHKKTTTHKRRVKMLKEIQHTQKDAEMAAGLYYCGNGRIFFLKSILTYKTRFLSPKNKNLLQARLMHQQRLRHEKGNFEMIPRMFHSSNQLVFRARLILRRFEIEFLYLLPVSRINILIKILFKLSKLSISPAQQNTIIERMNYIKNFFCKESGKFIPSNLVMKTPAYFEKYEIGNNNDLLELSENLLHKKSRLFVDKTEDLMELADSKIEKEMPNQLEYDEKSDEKFILKLERFYHIFIKIKELQDWIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL5</accession>
    <name>A0A4Q9LZL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0450p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000450">
        <property type="protein sequence ID" value="TBU13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0450p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19550" checksum="187631C63E58AD6E" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKETFVLEEKVVRKQNKYVLTPKSDNLKGKDNKASKKNKKFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR8</accession>
    <name>A0A4Q9LZR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0296p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000296">
        <property type="protein sequence ID" value="TBU16548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0296p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="8572" checksum="9E131201ED0F8CB3" modified="2019-07-31" version="1">MVEAEKFRKNDELENESNPVYRVMTWDGIVTKYHNLYLKNCQMVSFDHQRRLEGDRNYSDGVIKRAVIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU0</accession>
    <name>A0A4Q9LZU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0189p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000189">
        <property type="protein sequence ID" value="TBU19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0189p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="13608" checksum="06C18D6AC337419C" modified="2019-07-31" version="1" fragment="single">SSNINLNRITTLFIFIARCKLFCFIEIDCFGLKIKRSLKFNVNSEKEVPIIRENILDIFVKRETIYNEMLLCLQKKSLEFHRFELFEFLNGIISRDLGRYENNYKKLKKILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M115</accession>
    <name>A0A4Q9M115_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0179p0030</name>
        <name evidence="2" type="ORF">CWI38_0306p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000306">
        <property type="protein sequence ID" value="TBU15837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000179">
        <property type="protein sequence ID" value="TBU19892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M115"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0179p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0306p0010"/>
    <dbReference type="OrthoDB" id="2426083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="533" mass="61123" checksum="85B45704DB7B0EE3" modified="2019-07-31" version="1">MVDSEKPKNNKLKVPEDANEIKQTKPSYDMTNPCTLAIPEGNRLTALRTIFDSVTADTKERLRIVFLQYTKGLKKCREMAENRERRRIATCILVSKIKEIDSKFLDLIDRIVGEYAKAHIPEPITEAAYIMQAAQVCYDEATQKLSALKIKSLKKNLREFNSNLSNVIEFLETLIPKNESLNVYEKEITRSYRGLYERVESNHVVSSNNDTITYDDYFFLFLLDNHLTMFPSLDEFVTVRIDNIHNFFIKKLTNLSKYLCDIVKSSRYEKTLQANWFYCGLTCLIPKEFHREALTTVNDIVRNENRSTCSGKARDACRESNKSVTVQTDAESHSTSHLLFINDLELLEKDSSTFNKSAKMLSVTLSHYIKCKKFIFYNQSTFDIVNHLTIGVLQIEPADFSKLDDAVGAVLITFIEVGITSEDSLQTVETEKLSKYSLLINELSLIYKCNGIVTKHHKSQLKRLEIPMNKAETTSLDRQRGPYSEQMPKKARNVCHTVLLRDVIGVKTTNQKNTIPFFSDGIITSDLEEENGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A7</accession>
    <name>A0A4Q9M1A7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0069p0070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1A7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0070"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="39382" checksum="3D4AF41BC296AE16" modified="2019-07-31" version="1">MNRPGDFSEIFDKNNRFEYCGHIGKGTYGSVCLAFDRFKKNYIAIKRVNFYNSHVLAKRILREIRILKHLRNIQNVNLLIFIQKKDQIYINETRYILFQILQGLAFIHKAGIIHRDLKPNNIFLDCNLNVKIGDFGMARSNFYSDRRDIKSTYVTARWYRAPELLFKYPHYSYKIDMWSVGCILGEILFQKPIFASNTYYDQLKIIFEWNGTPSNDYIRNYASTSMKNLIYRVPLYSKIPFEAKFATIPSQLADLLEKFLEYDPETRIDTADALKHDFITECFLSPEININLYCPVPDHDKTFNEFRENFRDEASELLCEELIEKSLPLNPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G5</accession>
    <name>A0A4Q9M1G5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein Msh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0052p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1G5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0020"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03243">
        <property type="entry name" value="ABC_MutS_homologs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="807" mass="94544" checksum="29096BCC4497B487" modified="2019-07-31" version="1">MEKEFLTFYKSLEKNTFKMFYKNNFYFVYEDDLEQLTKNAINLFGCTMTPTRKESILELKITKQQGELLIKYFLTEKKLSVQEYIFLNNDFILNREGHPGNWKDFNEILISTEQTPYMGAVYQINKNTISFSFIDSLDKTIFYFTFQDDDILTNLFNFISEINISEIICCQNSILRNLNNMGITVNLVNPKGETNISPSASILIDFLKLKTYKLKEYFPESIMRVDNSLLYALNIYSLENKLLSKEFLNQQTNFDYKNYVEHNFKDIFSTFYCQTNQGSRLLHKFFKFPLRDLNEINKRLDYVEIFTKLNLNLKYFPDLLRISKRIENERISLQECLRLYQIIFKIPELLQSLIKYEILYQDFIFPLESLKEIFYDLIKEIERVIDLEKANNNEYCIRANLSCNLEKLQNDIFKIKNEIKLEYERVLTLNKKIKLEFSGTLKPSDILNSKSSTVCDDEIENIYFNKDINIAPKSEMGFEEYNSYKSTKNISIKDIHFSFKLSRIDFRSFQNEFKKNRFFEISFLKSGIIFTSKKLYELNLNWDKIIKEIIKEERTIKKELKLFLKNYISHIEIFNHVIAMIDVFSAFALKGKLNYSRPIFKENYFEIRKVFNPLLENNGCVLNSFKLEDRKICVITGPNMGGKSTFLKSCGIVSLFAQMGCYVPCEFACIPIFDGIYCRIGANDCTFKGLSTFMIEMIDISKICKSATSKSLVLIDELGRGTSAIDGLSIALSVSDYLWNLKCFSIFATHFPELCTEKVVSKRVKVHKESRDIVLTYELEDGVCDTSLGLFVADLVGFPQEVLNLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I1</accession>
    <name>A0A4Q9M1I1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0296p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000296">
        <property type="protein sequence ID" value="TBU16547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0296p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="670" mass="79805" checksum="9DC65F02B966E1E1" modified="2019-07-31" version="1">MDWSSKLVEHMANNPPFKPPCYEFEKVNKPTGKRPEGGITEGDYGSLMAVALDDEFIEVKHIEHIPKRDPNTEYNQYILYNTENIELKFDNFDKIGNENLNDGIFLYKSMTIEKFYTILYFLEYLRVKYDFTLRSCVKMIWNSLDQSKDLENLDVDKVSFHFSKQKIFSHELFKILSKVYFERFLSKEKNIYPLLFGIDNNSLEYTYEKLYTENNMQCLTLNETIASFITRIIDNGLIDKNLFILLLNTFDVKYLHIINMPPKNLQSYYFILKYIKKKIDEVVFKNVSINDELITFTGPLFIFYTGLDINKKDIITDSSVIQNLNTIKNIINNSMKGKIENWLFPVKKCIPSGINEQRNDENIYLSLFESDKFREKIKIFDPLNLKYKKWNLNGFYELNGDFYSFILTFRDFCLNRFEIKDIIVAKNIRKIEIKNSKIHIGFLKDIFCKSYINHLSIIESRIIMKENLKLKNSSHLIYKNDIILRFKNRKFYIKESYIFKISEKNFKGLPKNELSYNIIPNENNTGNYESYIGSLKLLFVKYNFGRINKLGISAFPIKKADFKAWKDLLCLRNLTLERIRFEEVCFFELFCPDEEYKIQSLDFTEISIGELVLKFISVLTQPRYLRLNNCQYFWSKFIQHIKEEFDAEKITFHQLEAHGIYILNEIQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T2</accession>
    <name>A0A4Q9M1T2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0314p0020</name>
        <name evidence="10" type="ORF">CWI38_0041p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000314">
        <property type="protein sequence ID" value="TBU03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000041">
        <property type="protein sequence ID" value="TBU20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1T2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0314p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0041p0040"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="269" mass="31795" checksum="ED339457F61EEC2E" modified="2019-07-31" version="1">MQRKYNNSKNKKNVDKTDENINKQKKNQRGYYIYQKYNDWIITDYSLQKNREISKFYYRRHFLFSKIESGIIMDYESWFSVTPEFLVKKVINIFNQLLNSKKEVICGYCGVGGDTVVFLKHGFDVYACDILYSKIKYLKINSSIYKKEQDKKYIYGNLSCEVSDFLTLNVDRKYEYGFLSPPWGGMDYKNSALFDLYSIDFDKITTKSQSIIKNCVYFLPKNCNPRQIEDIIKDSITVNIMFQERILGLVVFHGDDFLANKEAICLAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W9</accession>
    <name>A0A4Q9M1W9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0028p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1W9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0060"/>
    <dbReference type="OrthoDB" id="2193130at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020466124" evidence="2">
        <location>
            <begin position="20"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="665" mass="71981" checksum="4BE4C7E62EAAB764" modified="2019-07-31" version="1">MLYFIYITLIPLLCITTQPAEVDLSENRIVITNKGVYISKQNKDGDTENKGNKNVSNNTNNNKEESVNNKDGEKGANNNDSKEEGVNNKNNNKKAVNTSTSEETVNSSTSTESVNTGKDGNNKPLCVIPEIPSNNNKENKNGNDKTNNEDFMECSVNKSTIEGVSEDIKECIRTKGAGNSQNNNNEENKENKSVKGSEGTNDTIEKSSIRSGSIVSSSSSISPNISTRIGTGPTLDSSKSSNTTLISITSTNLTLTPNTSINTNVSSINSSPLIDTDSSDSDIEIYTSCTTIYESTFPNDRSSRNTTNINSISPVITINSITSSSKAVNTLSSNTSPSITITGALQSASISKTSSSTPITVTPSSSTINKASSSSLIAKTLQSGSISKSLLSTPDNKTPLTTSKTNSSQSTHVKTTSLPSQIKSLGKILSTHSINTLPGSHTSKPISYTPSSTQSSTISSTIASNNTSNSINNNLLIKHANDFKSLKYGMEIQCIISQNITFLKKDYDSTIPKIKNVLIYKTSDNKYKDYWNILIFTKGTDNIYIDETKYFEGILVSSYEDIPVQGKLSPLGLFQSKMPILDYIRDIQSIKLLILQIANTKGVSATDIVNTKCNLSLIDKIVFKHMYKEMDGVKEDKCVFVCVCGDSFCKAPCVEVKCVDRNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M267</accession>
    <name>A0A4Q9M267_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0017p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M267"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0050"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="25729" checksum="1E6E20BDC5120FAC" modified="2019-07-31" version="1">MIRETMKKMPMGLKTIQGNPIYCNEKTRCTIEKNGGESLRRPELSKSLGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQAIVLKKTVETISFDRRRGFESGLNAEESWERASMGVIMRSEMQEEPTPPLKEEKREEDSAKIFKPKNKAPFISQGETTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2A1</accession>
    <name>A0A4Q9M2A1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0198p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000198">
        <property type="protein sequence ID" value="TBU19802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2A1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0198p0010"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20769" checksum="3E09BA4CB771BDF4" modified="2019-07-31" version="1">MNYTSALIYMFEEDRRDIAMEVNIKKNSIIRGYFISMVETYGSFSAYIEIKNEFLLNNSYMKFNDEIHFSFSSKDKPSDFIPRIEFTYETSEDTFDKINAKNVSIDPAIKTLSKLRNQLHDVAKETKTVMKCLNEYSINFENFVVVSIYISLLAFLCSSFVYAIRIKNFFKRKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I5</accession>
    <name>A0A4Q9M2I5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit 10 of transcription initiation factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0005p0100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2I5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0100"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12698" checksum="C463A9D4ECD47857" modified="2019-07-31" version="1">MDDESFNKFKENLEEFTPLIPDVVIDHFLERSGIEHCDENVRKMISLMTQKFITDISTSSFQYHKINQKAASKDKRIPKEKKPTLQVADLEKALEEQGINISRPYYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L4</accession>
    <name>A0A4Q9M2L4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0004p0030</name>
        <name evidence="2" type="ORF">CWI38_0002p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000004">
        <property type="protein sequence ID" value="TBU05520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0004p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="122" mass="14954" checksum="7CEF9A0BBEB2BC58" modified="2019-07-31" version="1">MNDRRTYKNKKFEQNERILIRKVTKRILDEDNRYLNEAMLKKTNIFLFSTLNEIIPVFLKIVRDTIIFERKAIKLGNITYQKIFPLLKEAKEILYNFYTKFLYFQIDLDSNYYLKALVSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2S3</accession>
    <name>A0A4Q9M2S3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0159p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2S3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2S3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0020"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="19384" checksum="744C1336061DED32" modified="2019-07-31" version="1">MKNKYSVKIANFDGVKACVNKAKVSFKNTRETSRPLLKKSLEDALKYLADVENFKKCVPFTRFNGGIQCTSQAKGLCKPNKGRWPLKSVKLFKGLIDNLVENAKAKSMDPKVLVITHVQVNKAPKVHGRMHRAHGRVSPYNKSPCHVEIIATKQKVDVPLEDEDLKVEELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T9</accession>
    <name>A0A4Q9M2T9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0190p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000190">
        <property type="protein sequence ID" value="TBU19836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0190p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020260995" description="Macro domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="153"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="40028" checksum="706C4ECD2C45B82F" modified="2019-07-31" version="1">MIIAVILIIGSLGLIQFIRTRSKDGSSSNDKKNTAQENEKKSDNTKKQMKTHEINVEEENPLPEEKNVPPKEEEKKQEEEKQEEKKQEEKKEEVKQEEKKQEEEKQEEKKQEEEITQEKLDKQFDLVNQFRGMFLSNISLPTLKTEFKAMIVNTLGLRVSNIKMNSKLKYKDLIKAFNLGLDKICIVNAANESYHIDGDGLNAGLTEFAKSNGGLNLEKNQWKNLTDKDNKPVRVPVLSGSYAISDFNNGIIIHGVGPKACEVGKTPKEPKNLLEVKHRITDLYNNIYIEALKRGSVLIIFPKISGDIYANPGKDQSFTKTTYLNAVYSGIIDFLKKIKVEDRKILVFNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2U5</accession>
    <name>A0A4Q9M2U5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0001p0060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2U5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2U5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0060"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein pyridine nucleotide cytochrome reductase-like FAD-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU21035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="241" mass="28075" checksum="E398ACB9412FD4D6" modified="2019-07-31" version="1">MENYLDSYQIIEKYNLNHNTIFITVKKENIPEPQKTPVSHFFYIYNDDYSIKRPYTPIQNTPNSLSFAIKIYEKGNISKYLNSKKINEKIKLSKPIPKRKYNINEFKNILMIAGGTGITPMLQILEYSLNSLEDKTIFNLIFCNLSEKDIFLNNKLIEYEKSNRCNVIHVLENKETESKHIKGRININIIKKYSNFDFCYVCGPPPMIKDVCGSKGENNSQGSVEGMLKELGFYSENVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2V4</accession>
    <name>A0A4Q9M2V4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0058p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000058">
        <property type="protein sequence ID" value="TBU20517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2V4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2V4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0058p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="28201" checksum="7365CA4CD580A9BA" modified="2019-07-31" version="1">MNEYIEIEKRKHLSMLYNTRKHELLSVSDSARWLKKGNIRPRNEAVSCYMQDRIVFQGADGMCQHCNKIGKTIDHLATHYEKKARPDIFILDKRKNKVTFIEFRKYDLFANELGLVYKCSARFFIYVMTWDGIVTKYQKKYEYIQSILLKKTVETISFDRRRGLESLPNAEESWKRASSSFILEARMHKQSTPPLKQADNEEDDVKMENTKNILPFILDGITTAEQPTTNTNEELELEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2W2</accession>
    <name>A0A4Q9M2W2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0179p0020</name>
        <name evidence="2" type="ORF">CWI38_0306p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000306">
        <property type="protein sequence ID" value="TBU15838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000179">
        <property type="protein sequence ID" value="TBU19891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2W2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0179p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0306p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445382" evidence="1">
        <location>
            <begin position="22"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="443" mass="53786" checksum="E2C4C6C4A25CDDAB" modified="2019-07-31" version="1">MVNINIKILLVLCKFISFCMSTDCNEIYYNIDEYKKYFLEKSLDLYNKETEQLPSMPISIDFANLMFYENRVQTVSGLISNYIESKSSKAYNVNIHTADFSTKYPYKQILFESFRLERVYDHTWSLFSIRYLPLSTAKKPLRHSHKLIGQKGFKCFIFLLFQMYKCLRKMYNNYCNDLCYISIEDISNGIPKNIPEKYQKLDSWLGRNIYVVFYVKIFTEIKIFDKNIDKSRMIELFNGAFGMKAYYLYGSYNLYIIDTIKSNLYDKNTSIQKTTKKTIMNQYILSFDLEYPPNLYFGLNFLYPERSFGFYSYSHSTEFYYFYLDKYREENEYKFKILFKHSYISFEFNFNWYNSEQEIKNTRTSSTFYLRVITEESNDMIVILRSMDQKYFIIENVSSSNYQLCRPYFFDKKRNIHHQDKTYNLKEFFDYLVFEKHIYIFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2X1</accession>
    <name>A0A4Q9M2X1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0177p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000177">
        <property type="protein sequence ID" value="TBU19901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2X1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0177p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21047" checksum="F95BE82EFDCB4294" modified="2019-07-31" version="1">MYDCGCYGVCAHCKPCYSNPSLKKSKRKKISSKKSVKFNIITPQDIKREACTGVHKSTNGSEHGICNQTKNEQNLITLSKLNEGNICIHMNLAGFGGKQRKKVPKQKKKERIPQESESESKEEEEEDQEEVEDQEEEEDQEEEEKEENGEQSVTTVHQTFQASKTISNVGESPSTTEAQISSRAGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M365</accession>
    <name>A0A4Q9M365_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0164p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000164">
        <property type="protein sequence ID" value="TBU19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M365"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0164p0040"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="362"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="570" mass="65863" checksum="54FEB5DFF2FF6F91" modified="2019-07-31" version="1" fragment="single">MISERLPPPPTFHNTNHQAVVARLQEWPRSGILAVQKRFERMPRNSLPATLRYYNEKFSCTLDIDAQEENRERRRIARLVVRTRKLPSELIDSKILNLINRIIGEYADSCLPMTRTAVARIIQAAQLGFDEATRKEKPRSAWKANIESKTSKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSETLVKKNESLNVYEKKITMHETRKQFRKENRMFELFRGRFYRGLSERVESEQVFWSTMWNKNDKVVMIDGYLIPSVSDNHPTTFSSLDELIMCLEGTPQADWFYCGLTYFIPKGTQRKGSDYRPITCMSNLYKLTTKCVTKVVQIEVKRRGLLAENQLGAVRGWDLQGDSLSPLLFVLCMDPLSRKLNEKYTKRTVQTDAKSHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSAKNDTCCVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVKRCFHTRLNAKKLFNAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLCPECKERLYLPRTELGRCLRRVELRSEHMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4R5</accession>
    <name>A0A4Q9M4R5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small subunit of replication factor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0050p0080</name>
        <name evidence="6" type="ORF">CWI38_1414p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001414">
        <property type="protein sequence ID" value="TBU11047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000050">
        <property type="protein sequence ID" value="TBU20571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4R5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4R5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0050p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1414p0020"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="35624" checksum="40DD7EC58F68DC6A" modified="2019-07-31" version="1">MVLPLTEKYRPLILTDILGNEEVMYSLQLLVQNKILPHTLFYGPPGTGKTTTIRAISHQLYPSHTKSHVLELNASDERGIDVVREDIKNFASTVSLQGGQKLIILDEVDSMSKDGQNALRRIIEDFSENTRFCLIANYQSKIIPALQSRCTKFRFSPVCSDKVHDRISFICHQENIKITPDGLSALLSIFDGDMRKLINDLDGIISCYKIINKTHVHTVTGSIDKKEYINIYNSLISDTFDISYSTITHFKILHSIDLQSIIQEIVEVLINENIKNKFKILKNISDIEYRLGQGCSEDIQLRAFISCFKLNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M560</accession>
    <name>A0A4Q9M560_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0031p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="75764" checksum="D162C7827700D45E" modified="2019-07-31" version="1">MRLTIKVAFAISEFIAYLFFLISIDEVTANKVVFIFSEFGKEYSIVEKNNLERNFKSETTFPKNSYLDKKRRSYNINASKKIKLSNKIFVVDNIEKYPLRFLKITDEIYNSQKKINIFLNNSKLAEYIQFDNFMKTYYSPQKSFSVENFMYILYLLNYLKVEFNTDLKKIIYSLINNLKNLCFKPENCFDEIICKFIITDEFSFTLFKFVLSEFKISYFYENELLLTFFYETVDYMLPNRNNYFFGNENKRILFYFVTKPQNIDSVILYHVEINESLIFQRFSYSFVETLYQPFDDKLFGKLKENRPGEDEMGNERSKFLFLKNFNPKETKFFKTEDNNLYELNIEFINVIFDKFIVNNEYLNKNINILNFKNSKIDYNELLEISSVLTLKEIEKTKCEIIESKKIRKLSQKNFSVTSLQIYDTRISNMNKIYDFIHSLKNLNYLDLSNNTSKNFVENIPNSISRTEKNLDVFFFSNMLRAVWEIKEVSYFFGSKRITLGKISIPYFFKILFLNEELKNLDSLSLSECDFTHDDKESFCFTNINEIEFFNCKIHKLEFHELFSRNIKYSINSVTINNLDHMSFENCSLTAPAIFAFNRCDFKHLRFFTIEYSNDVGLSAEHFIHIYEEFGDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVU7</accession>
    <name>A0A4V2JVU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0011p0040</name>
        <name evidence="8" type="ORF">CWI38_0746p0010</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000746">
        <property type="protein sequence ID" value="TBU12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVU7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0746p0010"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033454141" evidence="5">
        <location>
            <begin position="16"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU05452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="427" mass="50731" checksum="E65F18795C4E8166" modified="2019-07-31" version="1">MKFFLFTILLVKCSEDTVLKLNTKIRIEFDDKSYEEYIVEEKLGSGTNGNVYKCKNQQSNEIFAIKLSNSDIYKRSIENEKHVYTNYSNEKILKFYKCGMYKWHISALILELGEKTLYQYLKNTLLKDKEKAILIRQVVLALSYLHLSGIIYNDLKSKNIMIFGKTKCKLFDFGLSIKARSKPELAFIYNDDPKKYFYLSPEFKKNINIDFKTDMWSFGVLICRMYSIEIIKNKPVFRTSDEDLKDCINICLQKDAKKRPSSSLILYHIFFDRIFTFLDEIEHIKNTFITIGTENILKKELNSIYCKYKNHEITLVFDCTEYIDSKIINRLTKDNITEYLERIRQLKYSFKVSKYVTYMIKYNSNPMIPIIELEYNCVSVIEKLIILLKLNFEDINLIKNEIESLDMKCFETNFQEIFQLKNNKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW19</accession>
    <name>A0A4V2JW19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2610p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002610">
        <property type="protein sequence ID" value="TBU06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2610p0010"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14544" checksum="E6B99D3381FE666C" modified="2019-07-31" version="1" fragment="single">MILENAALKKKYDICQHCNESGRTVDHLATRYEKMLDHDYTRRHNEVVGYLYLLFRNKFKLNSSKRIRIYSLSLDTRIKTDFKICNNKPIYSLQIVETEKLRNVETISYVMTWDGFVTKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW26</accession>
    <name>A0A4V2JW26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1900p0010</name>
        <name evidence="2" type="ORF">CWI38_2615p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001900">
        <property type="protein sequence ID" value="TBT98113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002615">
        <property type="protein sequence ID" value="TBU06222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1900p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2615p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="117" mass="13592" checksum="D1BCACA8509FD720" modified="2019-07-31" version="1" fragment="single">MLNSSANEEKCQLEKINKNTNNDTSEFLLEELLDYLFETYYIYIKSIIQIQSIEIDGSNDKASEIMSILSCNAHQKLVIFRKIASLNLALTYYYDFNKNHNKESLFSSVDDIPLAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX48</accession>
    <name>A0A4V2JX48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1773p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001773">
        <property type="protein sequence ID" value="TBU10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX48"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1773p0020"/>
    <dbReference type="OrthoDB" id="2374117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020837786" evidence="1">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="275" mass="32461" checksum="C507E45DB67769F4" modified="2019-07-31" version="1" fragment="single">MHFFCKSFLYLLFYIIRLIKASDKLPKPNTMIDKYKVIKEITSGTEGTVFLAIDDTSKYFAIKVYKKSVDIDRLFDLNKYNRSQLKHLNILLPIKYIKTADYTVSIMKYYTYDLFKYKRTFQNLTLYEIRIIMKQILDCVNFLKQKKVLHNDLKIENILINNLDIVIIDFGLACSESYPFRLVNSKITSLEKKEYPYFAPEVLNGELVSHKSDIWCCGVIFYDLICSVSFNPENRMLGSNDPECIQFYESMIHNRPSLRFDADILLLNSFFAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE7</accession>
    <name>A0A4V2JXE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1139p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001139">
        <property type="protein sequence ID" value="TBU11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1139p0020"/>
    <dbReference type="OrthoDB" id="2199512at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="128" mass="14715" checksum="8782E3CB2F384962" modified="2019-07-31" version="1">MYRLNPQKVIDIVKRCLKIDLVFVEKNGGDGVDSECTKTLYDKGRNMKGESAYLSVTAARSRNISVVAAMNKYSMIYHKIHERAGNREDFKLSIKYIYESCQRQGISTPNFVIDNARIHHYLGSNDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI7</accession>
    <name>A0A4V2JXI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0973p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000973">
        <property type="protein sequence ID" value="TBU11932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0973p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="61" mass="6948" checksum="8AF1351F65345507" modified="2019-07-31" version="1">MRASIGVIMRAEIHEKPTPPLKEEKREEDGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS8</accession>
    <name>A0A4V2JXS8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0584p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000584">
        <property type="protein sequence ID" value="TBU12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0584p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="279" mass="32712" checksum="A4B3FB79164CABFD" modified="2019-07-31" version="1">MFETLKQLSENEFCVFYKMIGLEINKERSAINDMICADTATLLDSNNNNRGYPTRSLFDELEEAIVRTELARYIDSVELRSERMLLQLLDCQKKCKEISTENTNNKLHKSEKEPEEAQLAKLFNEIENLLKKGNIRLRNEAKCKWGADGSRKTVDHLVTQSEKMLGHDYTRRHNEVIRVDTWIKTDTRYILFRLEEETITLIEKLRKCVLLANELDLIYKCSIEIITFVETWDDIKTVKIISLITEEDLRINTSSKHAIKKEDWAKQFNTKNNTLLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT6</accession>
    <name>A0A4V2JXT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0557p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000557">
        <property type="protein sequence ID" value="TBU13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0557p0010"/>
    <dbReference type="OrthoDB" id="2201046at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="594" mass="69640" checksum="654E90F6C185A762" modified="2019-07-31" version="1">MIVLCFIRSIFFTEIHKSSVQDKCQNINESDDREYRKDDIEKSQEKNSEKRNLDQGYKIRETYVEENKPNQVLRLKAISNIPTDEGNIGKNDLTMNTYNNCEAIPARNTYLFQNNYENPAAYYNQQIYQSQKARSFNMYETSPNRFSHSTSTVYPWFTNYAPSQSSSNINMQRNWSLFTEKFSKIKKIDYDSPLVSFFPGIIMLKDFIYKLLLGKVLQDRNIFNIFVGMKMIESLLFSSKEMISSFCNENSLDIFSYGYSITNIIIAHKRIFFTILKKILFKNFNLSKNFIISLRITEMGCVYLSDDKLYLNKAYKCHFLRTFIDSIFFLDDVLMNTVSNIYEKSIIDVDLQTGFVVHTFFDFSILEKIEIVPGLSLKFIKYYLILLQKEEFISSGNINQIVFKDVIENLTIEVDNFEKELTKPSDNTLYINMREVFKTSNEFVDRKVLDLINRVVREYTKAHVPQSITEAAYIMQAAQKPKSAWKENIENKISKKIVYALFITFSVDIIPYVMTWTKNIHKYCDIYAVDSIPNPEDFCDSVIEKAVRHTLPIPRLKADGVITIKEPTIKIKEEADIEEENIMAQMVESYNYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY01</accession>
    <name>A0A4V2JY01_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="4">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0352p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000352">
        <property type="protein sequence ID" value="TBU13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY01"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0352p0030"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="2"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="52696" checksum="896B59CD2C784CFC" modified="2019-07-31" version="1">MNVLIIGCGGIGCELLKQLYLSNFKRITLVDNDTISFSNLNRQFFFTRKDINKYKSEICKKKFIKKFPDAEISVIKNSIMDYNLEFFLQFDVVFNCLDNIEARSYVSMRCVFGNVLLIDGGTNGLKGQSEVYGKIGCFDCVEKEVIEYPVCSIKTNPTKYEHCVVWAKEYFFKEVFSNKIFDKNTLLKIITNQNTENISEDTFPESEELNDSKKMKIESTENISDGKFYKYEEPNNSKKIKKNTEKLYKNLYKNNQSDCKKLIDTVNHLLKNKISDFDKDNQKIIDFIYYSAKLRSKYFNINSKDEFETKSIAGNIIPAVCTTNSIISSLMMFSLKSKMNYYIVGNRKLISKVNCYQNKECICTYKKAIIFGDKIKISMIIKKINELFEINDLKIYDGDYLLYDKYFKDFLENEIEFQENKFLVVKNCQTGVLLYTKNGDKFDIREVEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY27</accession>
    <name>A0A4V2JY27_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0272p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000272">
        <property type="protein sequence ID" value="TBU17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0272p0040"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="35536" checksum="ADFE73F097125638" modified="2019-07-31" version="1">MLLQLLDCLEKSKEILTRRSAILKVENTNKTHLPLIKGIIKVKYKLEESVTKRNLEEAQLAKLYNEIEKRKLDSKLYNVRKGELGSISASSRWLNKSKIMSHNESTEIFSGDHKVLIQCIHLLLLNRYKFKSSKQIRSHSVQEFLIMSDKNDVKIRLGITSQDSLQIVEIETLRKYNLLANELEIIPYVMTWDGIMTKYHRTNVKRLQILMNIEAYIQSIVHKKTVETISFDRRRGLESRPNAEQSWKRASLSVILGAEMHKQPTPHYRKQIQGMKEPTININKKSDLEEDNEVVKRAEKMIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY46</accession>
    <name>A0A4V2JY46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0214p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13352" checksum="B4476CD8E6D2C3D6" modified="2019-07-31" version="1">MDREDQNYYKPRTNQRYSKESTTDTRKNYPTNTTYRYTRDTSKEHTHPSPYDRRRDNESMYPRNINNSYGRRYTRYGSSTYNKGVRVVRKGIPTREELDEQLIKYMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY73</accession>
    <name>A0A4V2JY73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0169p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000169">
        <property type="protein sequence ID" value="TBU19933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0169p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="22292" checksum="B91BFC4C1639A723" modified="2019-07-31" version="1">MVNMNLVDLKVEINEMEKQLNKNARKIKNNTKAILPRELVDYYTSESIKYKELITRLKIFVSQIEKTKLKKNLNNLITNIRLKKYDEIYKKLEEFEIELKMMDGIVPDEESDIDLFDDILKDIITKRYLVAIDKFMNICLENGYELFSTDLIEKCKNEQCLICKSRLKYIGMLSITGDDIKDIEYIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY98</accession>
    <name>A0A4V2JY98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0091p0070</name>
        <name evidence="1" type="ORF">CWI38_0140p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000140">
        <property type="protein sequence ID" value="TBU20057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0140p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="586" mass="69476" checksum="9B855553AC081B43" modified="2019-07-31" version="1">MLVLLYILFVQNSNIIRRLPIKSYIARRGFAFSNYRSNNDSFDPEIQKNNDIENKQKMKQLLIKCVDSNPSYKNIFENLDKKDYKSYFSFLKSYITDNMKTNLQIKKDEIFPLEMKASMQVLADRANYNPESALNPDSNDYSYELHNIGMKFNIVFNILYSIFLFREMNIINAINQYFSSNSQYLTSNKMKISIFSYYQFFSLVASRFNKIHFENLSIWKYYLKKNNSENLFLIIIILSKYVTHELYCNSNFVILSSLLEEIEEEKNILQDILYENGCSNILEIFRLDLCPLNIFIDDEIQIKSFLSAYLKESYRNIASNGNIWIQNNLKKEYHGIYFHVKNFFKEKMMKSLETKYSKDTIQILLHYADMMFLLNSNSCLSIKDYFKILSFIFFNHLNIKEENLLDSDGSLNVEEFLKLNYNCKTYFDICGNTFFEIEMLDNLLDVMTLIVVALSNEKLDVKYVKKQISLSFLVGFMDIVPTKIHKSMYDIFHINAWYFDPIGMATIRILYFNDYKILDNISNLKNAGLEKQIYHTLLLFKKKDGPFTINTENIVILNDTRKNLEMLTSIEYKNLLFFINLFMSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP6</accession>
    <name>A0A4V6MVP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0132p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000132">
        <property type="protein sequence ID" value="TBU20103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0132p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020840674" evidence="2">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="12870" checksum="2A487770ADBA5F0E" modified="2019-07-31" version="1">MNRKKLFLWIIQLTIILNFIKRVSKVNAGYSRRSYSSRNIRRSSGCSGGRQGGGGCKGGSCSGGRQGGGGCKGGSCSGGRQGGGGCKGGSCSGGRQGGGGCKGGSCSGGRQGGGGGCSSCGGGGCSSCGGRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3Y1</accession>
    <name>A0A4Q9L3Y1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0693p0030</name>
        <name evidence="4" type="ORF">CWI38_0992p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000693">
        <property type="protein sequence ID" value="TBU01511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000992">
        <property type="protein sequence ID" value="TBU11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3Y1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0693p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0992p0020"/>
    <dbReference type="OrthoDB" id="2186004at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="301" mass="35563" checksum="E7ED5674F5B1C1AF" modified="2019-07-31" version="1">MNEEIKRNTNRITIPLPDALRNMVKREMNDSDEYKRICCVIEETVAENDENDCYAALLEKIEPYLKDKTRNFVGKLFMFKKRICRDGERCKRGDNCIFLHENEAEGADYKNIEARREVFNNNNNIRKREFETEPNKRIKNDTKFSNKEVILNNLPEDLWDDVIISDYCKEFGSVSEVRMLKPGKYLIKFFDPSSAYKFISSTEKTFGRENIKKFYNKFVRKGKEEILQDLFDEQKCLLQEMQSIVGSEASFVRLRAICIKIRSLVNSEENSDRENKNINFKDNGINKKNSVYFNSFFNPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9H0</accession>
    <name>A0A4Q9L9H0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DUF4451 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0145p0050</name>
        <name evidence="3" type="ORF">CWI38_1307p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000145">
        <property type="protein sequence ID" value="TBU04369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001307">
        <property type="protein sequence ID" value="TBU11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9H0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9H0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0145p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1307p0010"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF2">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="1">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="189" mass="22659" checksum="444EF38F21B5E393" modified="2019-07-31" version="1">MKNTNYTYLDDFINLEFRNLDSSFNSLELESTDDIFHFQEYLLDKKTINEYYHSAIQSLNNEVFLPTIDTSVFKETSKSVVNDTNKSDKKNYSPKFVRGNGIMREGYCEECDKWFRLKTSSYWYHMNYKHGVNSSGQKYPHPNIQKNCGYYEALCESCQKWVYLGKKNNNKSINFCWFKHWQKDHDKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBX1</accession>
    <name>A0A4Q9LBX1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0033p0030</name>
        <name evidence="11" type="ORF">CWI38_0045p0050</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000033">
        <property type="protein sequence ID" value="TBU05234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000045">
        <property type="protein sequence ID" value="TBU20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0033p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0045p0050"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF8">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU05234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="88681" checksum="E86C7B5354FAD359" modified="2019-07-31" version="1">MLFIFYYELIYAISQKFEFVFLKKDIFTVKYWRIHECIGVFDEYQNFKNILKIGNENNSLDDKKIYFKKVVVLKFHIPKYILSQSDFLKTYLETSLNRNPIYLSNIISLEGFETFISLIHSRKLFIYFINQKIFCGIFRLLDYLQISESLTNQYFYVNLIQSVVTSKIIFDEKIICELFASLPNNFLLKNFLILFSYLVRSIKILDLRNDKDINKYSLGILKIHENVNNNRRILILKDNDVVYIMNNVENIWYRNIFKQFIHILLSVQIRIQINVFHVYTPSKLKLFSELFSVQELQIEGYYSYIFVPYLIDGPCKSTLRVLNLCGSRISERIFCNILKLKILQHLFLISCSITNVCYIPRFRHPNTLHLKYLDFSRTHITIKEIYQIYNLSQLEKIEMYGSNLVAGTVGFLKGCKFKSSLKHLNLANNFLNEQDISVIFLFSNLYHLDLTGCNLIDSNEIIYDNIACTNLKFLNLTYVNLNENLMKALNCFKSLEILTMNLVHYNGVIFKELNTCYIAETLIELNLSHKCLIVSDFHKIFLMKNLKRLNLTCTVYHSQENEIYSNLDLPDNLDVLDLRNNDLKNGNVFNFQNLEHLKELNLNFCNLSSLEFFEKSPFLFKNLEKLSLANNSFSETNLNILKKFKMLKFLNISKAYLKNWRIANLKDSLISKTLEYFDFRENGISYDDFLAVKSFKNLKNVRLFYCKMTFRDLNDQDILFLRNVCSIEIQNILYIDGNIIFHETSKHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCE5</accession>
    <name>A0A4Q9LCE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0001p0030</name>
        <name evidence="3" type="ORF">CWI38_0177p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000001">
        <property type="protein sequence ID" value="TBU05553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000177">
        <property type="protein sequence ID" value="TBU19900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0001p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0177p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="100" mass="10695" checksum="DDE265C9C2F3180C" modified="2019-07-31" version="1">MSCGHKSPGCSEQKPVEPAEPSGGNICIHMNVIRDPTALSGEESEEESEKEGEAEDEIEEVVTIYVTKKAVSASSAKSRKSSKPGKSKKSGKSRKSSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEB4</accession>
    <name>A0A4Q9LEB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2679p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002679">
        <property type="protein sequence ID" value="TBU05926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2679p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="5656" checksum="98C08FA65E9DE91C" modified="2019-07-31" version="1" fragment="single">MEVKGYLSKGVSIVFYMEGCILYGGRKGVNLEVKGYLSKGVSIVFYMEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHT0</accession>
    <name>A0A4Q9LHT0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2463p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002463">
        <property type="protein sequence ID" value="TBU07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2463p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="52110" checksum="4352A54DE874E6C7" modified="2019-07-31" version="1" fragment="single">FSAINQHAISSINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRAELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRYEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRTRSHSVQEILDNEYAEIRVDTRIKTDVKIRNYRPDIFILDKKKNKITLIEVGITSQDLLQIVETEKLRKYDLLANDLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLRRLEIPMNVEAYIQSIVHKKTVEMISFDRRRGLEASMGVIMRTERHEEPTPPLKEAKTEEDGAKNLQPKNNTPLISQGGTTLEEPTNNINEESDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI11</accession>
    <name>A0A4Q9LI11_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2351p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002351">
        <property type="protein sequence ID" value="TBU07788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2351p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="605" mass="68624" checksum="6908C9200DC93F68" modified="2019-07-31" version="1" fragment="single">MKYFPTLKNQILTNLTLAIIPTAIFIKFAIVFLRTYHLLFCKYNISSLKYSFTQPNIISLSYQHQGSTIPLNTSIKDIHIATQSASDTFTDQKFISTFASSNIFLKRRQEIKFESNLKITSLNKQNVLNFLKKRNHLHFTIKCKVILHLFSFEFSFNKESTFSIPPPASEQKGTYKVTEICLKNVINLDNPSLTPQKVVTLIDNTDIYQQKIVNFDDFLTQKNTTPAKSDNTKNMTEESERSDKNPIITQNQPQNTNNLTAECLTSDKTSNTTQNQSTKTQTENNTTDKTPNTIQISISPNNLQFSPFISLYLQPLCITINNTPLFTSNITITKGVLHPFKIYIPFISYKISLSIIKGVLFKRLIINSIKGTLNNTIKTLFNNTDITHMIPNTSNTTKRNNNNTYYKIPNIRFNLHSIKDNNIVFSTFIHNNIIPLDISLITNTKNVSSEISNNTKIKVANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI66</accession>
    <name>A0A4Q9LI66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2435p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002435">
        <property type="protein sequence ID" value="TBU07205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI66"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LI66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2435p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="575" mass="65802" checksum="D213ED36315EBE12" modified="2019-07-31" version="1">MYMAYTSLKNKNTNLDLKNLNLEFYNVCSVIIDEIKGRESVFIKYEKIRNNKYVKSYVVENNIVYHKYKDIVYENMDYSNRDMDNSNRDISNMDINLDNSRDISSDINLDNSNRDINLDNGNTINNTPNTNTHPLSLLDSALSTADESNITTIMYNRSFFCTKQENINILKELLKKENKIEYLLRLGYLEQDIEYYKECCSNETVYGFNAMASVYIRDSYCMARRVLECSKGSLYGCILLGYIGIVSGKDSVGGGSRGVGRDSNSNSISKSISSKYSSNHPNTNNISLALDWFLKGLKYNSKSPYCCLGVGLCLVEKGFKKEGIDILKGCYREVREVSYNLGKIFYDSKDYKESLKWYIEYYRGINNTTYNNSKDSDTTYTNSKEINTNVTYNNTNTTNTNTTNTNTNVTYNKFLRCLRDRIIVLALRLGEDTSNNKANGNIVNSMANNSTYTSKGNTYTNHTTGVGSVEYLLDGVLECVGMEEEVLICKIRMMVERNELEIKKYLKYLSGDNKRRVKGNEEERNRVEKKEENEESIGVVYVELEKYMSSISSRKSISIIQIISSIVKEFIVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJY8</accession>
    <name>A0A4Q9LJY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2343p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002343">
        <property type="protein sequence ID" value="TBU07845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2343p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="400" mass="45660" checksum="DB1AB3A4CFD99C21" modified="2019-07-31" version="1" fragment="single">SPNITSISISPSNTHIICTTITNELLIYNTYYKKNTHLFSVYNDGIFLPTEEDILLVTDNSCLKTLKLNKSKFEAIIERPRCLKNVVGINYIDGGVVIASKQGILYYSLIKEEQSYFAKIKIKLDVNEDNSNLKYYNGMEFTDLAPLIFNSFGTTGFIVLNSYIYKLSSKKLSYFLYEPSLSSINISKCSNFIIIGTYKGSIYILTIKSKSIMSEFSTTNSPIKYASMCIVTDRIILCYKNILEIRNISGELIYTKDFSCVINITSNYSFIAIGNCNGIDILCYKTGKLCRSLQIKNIKSIEFSNLNNYIAVMTGKFNIECCKVSKFTEADHDFVSSHNNIFILDILSGKVLQKIFLNNEVEYLKWSSDDAFIIIKYKDNDEIFIYLYILIMKYLISTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLG6</accession>
    <name>A0A4Q9LLG6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2176p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002176">
        <property type="protein sequence ID" value="TBU09173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2176p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26944" checksum="F42BC8F325F2ECEE" modified="2019-07-31" version="1">MHSKNKIGKILKLFFTFLQSLLFITGISISLIFITLYIKEHRLLEIPFKLLIYVIVIGVLFISISVTGIIISTASSIRGEGNSNKDNSIDNSNKDTKDKDTKDKNINTTHNTHVLNTLYVILSLTLLNILLINIIKHNKSISKIRGYASGRWNRLSERQKVFIQNRLECCGYSNSSDRVGGKGCVSSVGCGDRFVKIGESVKLAVQRIWVSVFFIVDSVRYYIRVRVRWFDCLDKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN90</accession>
    <name>A0A4Q9LN90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2105p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002105">
        <property type="protein sequence ID" value="TBU09849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN90"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2105p0010"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="912"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="264"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="912"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1218" mass="140200" checksum="75A73CF5324A5381" modified="2019-07-31" version="1" fragment="single">IDNSIDNSIDNSISSNILDNSIDNTIDNSISNPTNPTLSPITTSNPTNPTPPTSITPPPHINEINELEISGMLYGLGLQGKLDTINHTFIYNIDTTTYQLLTITSIISICISKRSTCDPLLTKYLKNIIFSKPSYSLKYACCIGLSFLFYKSYNKSIFNILIKECNRYGCYYSDMYNKGNKIWYDEYYRVGIGLAMSLVFMRESDLDNSNSKDLDYSNNRDNRDLDNSNRDLDNISNKDLDNSNNKDNCNISNNKDNSNRDLDSSNNSNNSNNSNNSNNSNNSNNKHLDISNNSNNSNNKHLDISNNSNNPISNNNNPYTNNTYTNNTYTNNNTNNNTPTSHTPTFFNYFTLKNNISFIPLKDSLCELLVNGLIFFKSNKKKIINYLKRSDNSKLQEIFYSSFFCKGICFNEEEEDILREVESIYMFSCSDVEMYRISGLLLYIGIKVWSKIGSGGGDVGGGGSDSDVGRDKYRDKYRDSRYYSNNKDCSNKGNNKDTNNTTNNNTTYTNNNTNYTNNNTNYTNNNTNYTNNNHQNTNNTTYTTNIKNRLIAICLFAEERVKKNNIYKILLDSSLLSLVIILNGTLDLEVLRILRRILKKLERSKYLNEISDFNIYENGCGYEVQYGLRYGDIIKYKMLLGILCCGMGMYRMRFSCFGVFCVVCSFYVLFPVSVCEQEYFQMYRYFIVMCFEQRYYMSGRECGRDKEYTKDYSSSNRDKGYISNKDYSNMDKDSNKDKGYISSRDKDSNKDYSNKDKGYISSGDKDSNKDYNISTRDKEINNSFNNHTNINTNTNTNINTNANTNINTNINTNTNTNNIQDNNNLTTDPYLLHFNTFNINFSDIDGLNNNNDNFIEDYLNESLCDLEEEEFNFNENMKGEEEIEMYENRSVFRNIKGNDRYSNGSKVEICEFSKSGDRDGGDSRGSKSGDSISRDSRGSISRDSISKGSISRDNKDNTNKSNTNNNIITNNDTTVNTFDYKQLLVVKNGFYLLKSVLVESSKGFLKDFLRLESYKKKIVLDILSNYYEENGQKYYSMEIEILKELMCYTLCRDIVCFIIYMFYYMFFYMSFYLFYIYSCHTRLNAKNLVSEINQHAISLINYHIGVLRLTPADFSKLDEAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENSNKTHLALIKGFLKVKFRLVEEVTKKSLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNV7</accession>
    <name>A0A4Q9LNV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2130p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002130">
        <property type="protein sequence ID" value="TBU09656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNV7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2130p0020"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU09656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="413" mass="47440" checksum="47F79D7AB0676F55" modified="2019-07-31" version="1">MSSFTSILLMYFPEKQAFEMLTSIISNNNLHSLFDKTLSKLNLILEIQIYIFKKNIPNIYKHMSYNKIEPSLYIYGWYLTLFTRFPIQLVLRIWDIFLFYGFPILLVSASSILKEHEILILESQEEQLIEVVNKIEGLSFNVERVIKNLKVFLKQLDMSEIRRKLGIDYYKGVNNSIDYYKGVNNSIDYYKGVNYVSNTIRSLLFITGISISLIFITLYIKEHRLLEIPFKLLIYVIVIGVLFISISVTGIIISTASSIRGEGNSNKDNSNKDTSNKDKDKDTKDKDTKDKNINTTHNTHVLNTLYVILSLTLLNILLINIIKHNKSISKIRGYASGRWNRLSERQKVFIQNRLECCGYSNSSDRVGGKGCVSSVGCGDRFVKIGESVKLAVQRIWVSFSHTSNTKDEVVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP45</accession>
    <name>A0A4Q9LP45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Symplekin tight junction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0235p0050</name>
        <name evidence="2" type="ORF">CWI38_1961p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001961">
        <property type="protein sequence ID" value="TBU10179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP45"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1961p0010"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin C-terminal" evidence="1">
        <location>
            <begin position="442"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="601" mass="71401" checksum="3143C95C40805C8F" modified="2019-07-31" version="1">MKNEILKILYIPEYEIADILAKARKMNPSDFLLLLSTLYRIINKDNCKIIFPFILDLSENPLELDPIYHRSFSFHFKCLLTKIKYILPESFTFLYENIENIKFKTKKISEANIKTEKKFLPFEFIYNIVLEALVTASSKEIENIIDCYFGSSKEDLMFKPNFISEILKNMVHLKEDKNINNCIKYIANILTKDDTNQLLDFLNQNYSLCNIFFLTIFLYNFDVYKNIEEVVLSTQKYFNFEIITALIEIDIQKVFNFIDESKNEDIKIPLLKNFIENRPKNENEIIQYLKENKIQKDLLVEFFKEYFCHFKSHINEFEFTLEEQLSIAECDDTLFYDIYSNNLNELNKTMKYLTSRNDEFIFSFFSEICSQNTNFNKNTIDESIIWFLRYKKLPENLKSLFVKRLSDNSAYFFALIFYLEKEQIMSLMELFLVDQTSLQMFLKVLSSKDILLNIHFFSDLKKTAHSIQLCLNNKDIFNEHVFIYVITTLEDGTLPPLFMRTVVLALNEFPNLKKFIFSLLFRLSRRKIWQFPKLFEGFIKCLAGMGSSSVEVIMTLPEDIAREIIFQNNKLRKYTEDYVSSTSGYKKKSSWILKNILKSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPK7</accession>
    <name>A0A4Q9LPK7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0347p0030</name>
        <name evidence="3" type="ORF">CWI37_1104p0030</name>
        <name evidence="6" type="ORF">CWI38_1239p0020</name>
        <name evidence="5" type="ORF">CWI38_1823p0010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001104">
        <property type="protein sequence ID" value="TBU00122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000347">
        <property type="protein sequence ID" value="TBU03149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001823">
        <property type="protein sequence ID" value="TBU10359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001239">
        <property type="protein sequence ID" value="TBU11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPK7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0347p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1104p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1239p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1823p0010"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="101" mass="12226" checksum="F5F92CFF2A492026" modified="2019-07-31" version="1">MNQETQFVIIKNIKPEKVYELFSTYGKILIAYIGIEENSESALVAYEKIKFAKEAIRIMDGYFCDGKYLDVKYWQYLEEYKKRQEEKRKNDYIKLKRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPQ9</accession>
    <name>A0A4Q9LPQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2143p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002143">
        <property type="protein sequence ID" value="TBU09505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2143p0030"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="80" mass="9017" checksum="38FE5049248E8662" modified="2019-07-31" version="1">MGVPYVDIELSANPLLYDLMTIVYGYKYVPAIFLCGEFIGGYDKFLEKYNLTTDDNSVFDNTFNVKKPMIQTGVVGCTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPT1</accession>
    <name>A0A4Q9LPT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1753p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001753">
        <property type="protein sequence ID" value="TBU10448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1753p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="357" mass="42545" checksum="45AD8060444E91E0" modified="2019-07-31" version="1" fragment="single">ECEITEICEHSWLFGFLISEENLHNVMHFRCKNLYWSISGRICNFNKLDKLKIKLITLDINELIFFDKFSHQFAILKLIYSKIYSNVLNDILSLESLEYLAFSDTKIVMNNNASFSTFNYSIKYFEYHGSLFHNFYMIFEFIRMLVNIKTVVLNLTEDFVPLQYEEKFIPIKKIENLIYKNFNAQINHSSAINQFIATNKLSLCFQTKYEFLRDIFCENNFDTIEYLEVENIFCRIYDKNILANLNQLKEICFKKIKLQGLSFCDLFDQTMNYNIFSVALWNIFISDNDIRFLNNLKKLINLKFYDCMFNSHLIECIGKCSFPNLKYLLLRISEDTVIPEYVLYLKEIFPVGILSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN0</accession>
    <name>A0A4Q9LQN0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1512p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001512">
        <property type="protein sequence ID" value="TBU10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1512p0010"/>
    <dbReference type="OrthoDB" id="2142724at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="33197" checksum="D6125E6D9341E95D" modified="2019-07-31" version="1">MVSINDRECIIEKTLEGYSMSAISSNYRINYQTAKSIVRRYLKTGLVFVEKRGGDGRSKLTLEIKESLQTYGNFEQWVKCTFYVDVSTSTIDRALRELHYTLKRVTLVPERRNTLSTIELRTNYATSFRELEVDNDDKNFVFLDEVGRGRNMRSESAYLSVTAARSRNISEVSAMNKYGMIYHKIHERAINDEDFKLFFKEINESCQRQGILTPIVVIDNARIHHYQGLNDDEEFSLIRGGARTESQLRILICEKFNEITGEHCSSFYRKMLGYLQKAEIGQVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQP3</accession>
    <name>A0A4Q9LQP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0334p0020</name>
        <name evidence="1" type="ORF">CWI38_1602p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001602">
        <property type="protein sequence ID" value="TBU10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000334">
        <property type="protein sequence ID" value="TBU13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0334p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1602p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="20266" checksum="D23813ED3BFEF78D" modified="2019-07-31" version="1">MYIRFEYGITKKRCPDIFKDKKIMFKEHDISFLPDILLYLKESDIIEIIAFNERKILTLNVKHSHRSPVSVNFITQNEIVLSKELLIKIIACYFLIFEDDEINFLEAFNYVDIVKHGYKILEKRFEAIKRDFILFDTCDRTLLRRLLYDTFYFFHYCNAIVIILDILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR07</accession>
    <name>A0A4Q9LR07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1434p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001434">
        <property type="protein sequence ID" value="TBU11003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1434p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="20853" checksum="AB06B798FE1D6BB3" modified="2019-07-31" version="1">MIQLEPKYLFKEISKITDYIMKRYKFKCYQKQIVYVSDDIKYILVQSDLTMYNDIIFKICFYSTRNVILTLLGFKAYRKIDDFSLSSILRYKSLISLLSVEKLTHILKKLYLLQNKEVMMDYLLEINPLKLRRILVLASLQEKGFFDELSQIYKKKEFLESYFVDTLRKIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL2</accession>
    <name>A0A4Q9LRL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1980p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001980">
        <property type="protein sequence ID" value="TBU10155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1980p0010"/>
    <dbReference type="OrthoDB" id="2190075at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="481" mass="57210" checksum="FFEC085CE82B615C" modified="2019-07-31" version="1" fragment="single">TRNIYDEIEKIFFMFYGTISETESKDINIDESKNLSNFNSTLLMEDIFDSKNSEFRAPSISINANKKENRSSVNNMEATENSFDNILNRNLLESILVFMKKIEIEFSYLSQNFLELFLQNDNSNLMKWFIQYFDVTEKLNNNYDSISLCYGFIWLIIKEKYEKIKELNLTKFNVNEFSYLIDFLILFKEYGNVKIENSLNNNLNEDLLFDSPSIEIETVEKIQNILEEDILPEKIELPKIILYFDGTNVLKNIFSKCFLKLLKFLMNNKNEIHESFKILNSEEIESKENKNEQMIQTNFKLKEKSNNLIISLFKLININIFSEISYLLYYTSPDIIKEIIIRINNKEAIINGFFFYLEKNIELFKSNQNENNLNKKFAKRISLKKQKDLQNKINNFILISKFLSTKMKKENLIFKNIKRFYDKGYEYPSLNDVFKYFISNLDENECIVLESMTKDDKFKRILSKKCNKKSKNESIKEVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT9</accession>
    <name>A0A4Q9LRT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1455p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001455">
        <property type="protein sequence ID" value="TBU10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1455p0010"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="10957" checksum="921CC4AF9E1C9226" modified="2019-07-31" version="1" fragment="single">MQNAEEKVISVWIVPSRQQKHKKQTLIKGIPTEQQQNTLRVLKKEMSCVGAIRQEDGGTIELNGNFSYSIENILKNYFSEYSVNGCYKGEGVNVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS47</accession>
    <name>A0A4Q9LS47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1237p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001237">
        <property type="protein sequence ID" value="TBU11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1237p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18724" checksum="1A300B7A754B8867" modified="2019-07-31" version="1">MKSCQNFDFDTDIIEIYLWTLSLYGFHIGKNDKKMLGNLENLISFDLINCFLLENSFSELFDEEKKYIIEDLVLNSIDITTHDVFFISKLKSLKNLTLLYCEFINKSYESLRGIYFERLEFYRFAAIDSCHDDAQIVHFTEEFGPNIFSQQTEELSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ8</accession>
    <name>A0A4Q9LSQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1564p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001564">
        <property type="protein sequence ID" value="TBU10761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1564p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="340" mass="39650" checksum="050C6B6DCBC482FB" modified="2019-07-31" version="1">MNQVSICIGLLSASFCVLLIFVSVYIGKKMKNQLLEEFKIFGKSQFATLLKEQFKDNNNFGFTNFKMKDSNVLGFCYSCSQNEKMIAVIIFFDKISQKNNAKEDKLQFYVIKKHADNIKDTNLVIPPYIFSLKKLKEFKDKYNTGVLTRFGLHLTLNTSEINVINKLVTLSEELASEIEVFSFLNANLQDKSIQISIAGDKLKNGTKNDLNLFQSSTNISLKRNIISDDSLREILLAFISDIYMYFVKFEKYSFYHNYKIEVFLRKLEHIKNYLKSKEGLEWIQYETLISIFIEQKNDIMKSFDDIETFLGNFKSFISIQDKDSLVLKIYENIEGKYNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ1</accession>
    <name>A0A4Q9LSZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1227p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001227">
        <property type="protein sequence ID" value="TBU11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1227p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="798" mass="95716" checksum="561189354EA0445A" modified="2019-07-31" version="1" fragment="single">MKLGMNIYNDFFLIYLIKFSINLILNVNIGKESIVFTFFVKFVLGREIILVAKEDLNNSSDNFTFIDENFIFGYKKNDTTVLCPCNHEIFTIGIQCSENIKYFHFKLRKIIIQNPDEYILNSELIRKINDDFSMSNIIILDMYSYSKVKEYIKYLQNIDLAMSDISINQFSKIINFINELKFIDCKHINELISFIAFNTFIVRKEELKYDLKDLENIEKEYFSVKFVLKIFKYCFKFYFRNIEAIKKTIGINTESKNSLYTKLIKYHNKNEIPIIFSKETSNLLYKILINRNLYSIIAILFNRLNVKCLIIYGDNLHYLVPNYIFLGILPNRINKCRFIIIEQRIEYLQNYFKKFFNRTSLKKIELTVNYLTEAFIEALGNLQNLDFLKIGIFEYNNVILNSILKLLDRSTTIFIELTLRNIDFHDIFDSNTYKYLEHYQERISFGIFTKDLRNLKIKFKEIGKIHLITGLKVFLDGNLAKNEKYLTKLFSLKTLSINFLFKNQFFIKSKFLFLSKLDKIKSIRMSNIRINNNLLKYILFSKNLKRIYLKNVTFSTKINFLKYERYKNYTLEEFSLDKTENVPSGFFSQYLNRFPTVYFLNYVLIQTEKLILKFTLVMNNLFDSFKPDTKNISHQEYTFFPQKLHLNKVFFDSELFERLFMTDWNIIYLEEIYLEDLKIYRENLMHFTKINSLQIISLHSVIFADSNFSDIFLQISNLTIQVIILKNIEIHEVDLLRLNKLINLKILEINFCNFSAKYIKLLRYSHFRTLSRFYFRGYLFSKKLRNIFDENFSSNVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT05</accession>
    <name>A0A4Q9LT05_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1500p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001500">
        <property type="protein sequence ID" value="TBU10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT05"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1500p0010"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="285" mass="33829" checksum="0F3B1DE160E9FB5A" modified="2019-07-31" version="1">MKNIRDYKNLEKYKLEFFEDKVIFGFKNNPIFFKIFDGWFIYKDFLIFKNIFTKKEFNKIVNKNKIKIIKRFKMDSKKYFNSEEDKAIIHNYNTNNILEMTKNSKNATTEQIKIPLFLKYIDMKSFVHLYLKNSSIHGRGLFANQDIPPNTRIIEYIGELIGERMADKREKTYIENGITSIYLFRIEKDIIIDATMKGSLSRFINHSCLPNSFTKKVYENGISKIIIHSQIEIFKNEEITLNYNFSSDKSKTKTSCNCKSINYDAKIENTKNIIPLIFNERNQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF5</accession>
    <name>A0A4Q9LTF5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exonuclease 1</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_1043p0030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="PITK01001043">
        <property type="protein sequence ID" value="TBU11774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1043p0030"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0228">DNA excision</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="7 12 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="138"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU11774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="45583" checksum="CF496942795AA551" modified="2019-07-31" version="1">MGINGLLPLLKNHLQRKHISCFKNKRIGIDGHCWLYQIIPYIAEDLFYNVPNKRYVKAFLSKIKSILSHKIIPVVIFDGDHLPMKEHTLNIRQERKQKAKQEAMDALKRNDISRAKELMKQCVNVTREMVNDVIEELIKENIEFIISPYETDAQLTYLQNIGFVDCILTEDSDFIVYGCSSILYKFDGEFVSLYEREILKKVKDLFFYENIQKIAIMSGCDYIEGIKGLGVITAYKTLKKIGSEGLLSFLKQKNLDENFLKKMENAIKTFNHQVVFCPIQQKRINLNPLETNLYFLGDLIGNNVFSKNLNTFATKNLLKYKNTESKNETKRVLTDIMDTPESDDDLNDPKQDVKENSILRISLKNKKKETNFKKKKIVFEEKTSKYFKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM9</accession>
    <name>A0A4Q9LTM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0043p0080</name>
        <name evidence="3" type="ORF">CWI38_0964p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000043">
        <property type="protein sequence ID" value="TBU05163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000964">
        <property type="protein sequence ID" value="TBU11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0043p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0964p0050"/>
    <dbReference type="OrthoDB" id="2188797at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="310" mass="35587" checksum="1A41BDECF6C46512" modified="2019-07-31" version="1">MLLLYLIARYILCEDSNIEIDKSNILSNFGNMLRAGIHKKYGLDMFKGEKIGMYTSQPSAAANPAPGCYIVYQNQNPQYPTQMCPGMPGYNPAYAYQNPSVPTAPNNYNSTTTVTQQPAVKSTSTNPPQTVQVAPSNPNATKKVTKVSVSSKPEQTELEKFIEKNPEVGKQLAKIFEYNGIMEPWDPVKDLLDLKQQRLPDPHTLYDRIRNMLKVFETLKELISDELVKIEIYVKRAKTYYKEDHDTLARNLAKLKKYMNKIKESHNHEVKTDYASKFNEVQNETNELMKRSQKLKQWLTTTLQSFKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP9</accession>
    <name>A0A4Q9LTP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0996p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000996">
        <property type="protein sequence ID" value="TBU11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0996p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020709717" evidence="1">
        <location>
            <begin position="17"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="424" mass="49618" checksum="9AEAF1BA2462CD35" modified="2019-07-31" version="1">MNILLVTVNIILCTQSLDRIYEEIEPKTLDDVYDSVKNLCGDLMQRIGKLKCESLKKICVLQCADTIGSYIVNDLISSFVEENEHKLNVVRVGLKSSGLTAEKRHSISDEIAKMIFKWQRNSIKKIPAVQNLDVLENIDFFESENRHKMQKVESLSKFISKDTFHDASDDFSCMDMRKCTYFIVFAGMLRRMEIFALREIINFMAKRTIFADKKVFIFINDSLQKSVENHFKTFSETPVFLDTFYSFETIQLNSFSAHRCPLVSNEDAFVKRDVYIIGLDQLKIHEDVLKANQDKKEISIRKINSRNEIFKNIIFKYELKWLTKISLINLSNNSTLLFFYVYTSLQRGFTVKIICENVQPDSKKIFINFFDSINDINNRLLFVLGNSNYEITQINEKDRFEGQVIFRDFRKRIEQYISNALMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ1</accession>
    <name>A0A4Q9LTQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0030p0010</name>
        <name evidence="3" type="ORF">CWI38_0943p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000030">
        <property type="protein sequence ID" value="TBU05248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000943">
        <property type="protein sequence ID" value="TBU12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0030p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0943p0040"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="91" mass="10253" checksum="4B2CBD2A38870B7E" modified="2019-07-31" version="1">MAFKKSESIKRCGGILSKNRAMICDKCSTMCCICKDFLSTSYKAYICENCASFSPSCVICGYSIADNTAYYCFQCKTLEKDRDGCPMRHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU07</accession>
    <name>A0A4Q9LU07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit Rpn10 of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1031p0020</name>
        <name evidence="4" type="ORF">CWI38_1076p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001076">
        <property type="protein sequence ID" value="TBU11698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001031">
        <property type="protein sequence ID" value="TBU11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU07"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1031p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1076p0010"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="23873" checksum="670A95CF475D7EF8" modified="2019-07-31" version="1">MPIAVMVVIDNSMYMQNQDYLPSRFMTQKECLNTYISTTLNDSVDSAVGIIPTCQYVPNIMITPTNERFNLNQFLHKLPLHEDFDISKSFKLAYLALNYRQLEEKSILVFLGTEIPTKLEDEMIKSFIDSICVALELGITVSVVFFADGIKYSEWVNEEIESNGFKSVVVKEKESFYDAVCSLTGCKSEEFEDDPELALAIKLSLEEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL1</accession>
    <name>A0A4Q9LUL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0797p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000797">
        <property type="protein sequence ID" value="TBU12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0797p0030"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="167"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="36075" checksum="0A001234C92028D2" modified="2019-07-31" version="1">MTILEYKIYVKNKENIEKMLSYSVTNSMKILLIIQFDCEKHHIIRKYYHLIFLLKKKNKSKSVIFIGFDENKETDKLKLLDISNIEDYINYNISEYYNSECEDDECEDNSTANYIDYKHDAAIVNIAKIDANNITSCDTTNIFESNIFRKANIDCKLYNDEKYSSVVVGGTFDRIHEGHFLLLSTAFLLVKEKLTIGLTTEVLHIKKAYKEIIQTYKERKEIVIFFCKIFGIKKAVISPLSDFIGLTDKENFDCVVVSEETYKVSLILNEIRRKKNLALMKIVVTPMISTKTYRISSSELRRKELSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ0</accession>
    <name>A0A4Q9LUQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1256p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001256">
        <property type="protein sequence ID" value="TBU11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1256p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="607" mass="70322" checksum="5AC4E0C8BD402A83" modified="2019-07-31" version="1" fragment="single">KNLQNLHEIQPSIAENENEILNKYFNWYKKNVNEDTQYNDILYVLHDPTQNEALMNHNIDINTIVDQNGNPIPDAKSKREILVNFLLYYKSFVNPNGQDRHPHAKKRHDISKKTYAISDINKNFKEDVNQNIQKPINYSDLDSAETHSNEKYDKFVQIFQNQENTETLNSLNNNDFNENHDIFPPQYFSNTYPGATEDKIDFYPNTTESNMTKSKYPDNKSYMPGVHSNIYRFSNTDDKIYDSGIPYVFDRNNLESNVMFREEGADSHSNIGSEYKNPNVSYTNYFNILSGLDSNTTKNTKNTDKAIKKFDIAHQKTHLGTPNMSESEYFTYGNPNIGVIKEQGENNDAGIVGNIESGNTLNRNPYYNSLYHDINSNTTKDTNEFNNAKKPGIKYGTNKTESLNTFKGNGRYDENNISKATDYMPRDSESNNVQRKTNIFLIFLKQIHIKEKITNNNTCYLSIRLLNSMLYEWLKKGNIRPAHEAVFCNTQDRSELWGAEGMHQHSNNSINFENDYAEIRYDPCLVDELGIDLKFCDNLSCDQMEWYSDNDQKSKPRSDLKTEKCWNRVYICVIKQPKYGVKCVRTNNIGLFIEAAGTEDKDKRNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV80</accession>
    <name>A0A4Q9LV80_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0700p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000700">
        <property type="protein sequence ID" value="TBU12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0700p0040"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12884" checksum="F5E9760B6D1CADBA" modified="2019-07-31" version="1">MFNWIQKYDPIYKANSMAKKYLAFLIKNIDVYTNRRKRSKQENLSSEDKKNNHVESEHHRRDAINLGLYALSEIIPGPVSKSKKSVILNAIHYIMKSRYENSYFSKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVF9</accession>
    <name>A0A4Q9LVF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0671p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000671">
        <property type="protein sequence ID" value="TBU12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0671p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15914" checksum="19A00B0E456FC8EA" modified="2019-07-31" version="1">MSYLKEIELHYYDDLICFGLGNPKYDFKELQISNLYVPWYFLDIFKNNLYFDFIPVENHVLNYICLSSLQILFKKYKFSRLKKLSLYKLPVFQEDSESLSNLSYIEELKIYKIYSKNITFLNYFVSQKNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG5</accession>
    <name>A0A4Q9LVG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1122p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001122">
        <property type="protein sequence ID" value="TBU11600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1122p0020"/>
    <dbReference type="OrthoDB" id="2201204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27995" checksum="CC11E92EC24F4CAC" modified="2019-07-31" version="1">MSTKRKLKSVTINYTRFSSLDNLIEIINNSSHFQIQILTLEAFETFSEYLKYKSIPYKPIYPSLTNMYDKKILNIIFEHPNTNLVNYKIILFNKSIHLDFIPYIFTISQSEKLNYLKHKYSQNLISEIKKPLFLEKNIFQLSNHIKFINFPICTLILTYLEKVILFALNITNRYEYLFKTVKEIDNNLGNSFLIKVTLNSLVNKNVIIKRGNIYSIIVDRKTIEITLKSVGFDINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG8</accession>
    <name>A0A4Q9LVG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sad1/UNC-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1038p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001038">
        <property type="protein sequence ID" value="TBU11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1038p0020"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="23972" checksum="04F0D6F603BAF16A" modified="2019-07-31" version="1">MSSDHIKRAETILNTKNDNYLMGKCKESFIIVRLCDEIKIKLIILQNLEWQASFPKRVKFSILNNQNWYEIGTFELLKKRSPQSFTLNSPHFSNILKIEILDFNGKFDIFTLSSLKVFGTTMMEDFKEKEFIKTQGMNLYDIFSSKIIKLEKYNELKENFIVFELEKQFLHLKKVVYKLKNCVLLILLLLLLSLIFILIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ3</accession>
    <name>A0A4Q9LVJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0655p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000655">
        <property type="protein sequence ID" value="TBU12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0655p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="10211" checksum="40428EC434635B57" modified="2019-07-31" version="1">MTFQRAKERNFDAKEKPSEGMCQFCNQFIKKSKRFNDEFQEILEMDIQRKNDTGMTSLKKFRTIDQMYLFYKEEIKYTLNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK8</accession>
    <name>A0A4Q9LVK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0810p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000810">
        <property type="protein sequence ID" value="TBU12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0810p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="343" mass="41598" checksum="E39F8C015A96C747" modified="2019-07-31" version="1" fragment="single">FSVNGIHFYTLISHIKFYLKRLELYERFYCRSSSETDLAWIFDETKKLILFQWKDFKRSLYISFFPELFGFGTFINDKYLQSDLKSFHLFRNLFIIHIICSRSRETIEEEKIYFPNKGRLYQKKNCKIILSDQETILSFLILFFESLKTDDIFIPIYLSFRSKLVSKNADESRFTNIPLKKVYFDLFFMLDVKEYVKIHVFLWNNSVDTISNKKIFAQISRYLGFGRLSFTRLDTIKWIIMYKNILTELRFYIQEINTKIAFTLHQKEFLLYYDLFVKCLIKILANEFSLDSMKILRISAKFYKCAIRFLWNVMFEKINFDLAPEFRNEINNLLNKNAIFNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL0</accession>
    <name>A0A4Q9LVL0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0765p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="PITK01000765">
        <property type="protein sequence ID" value="TBU12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0765p0030"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="19969" checksum="9B9E3BC572AA9529" modified="2019-07-31" version="1" fragment="single">MVSDEKLFLIKRNLQEILSEEILTEKPKNEKIKIYWGTAPTGRIHVAYYVPLLKIRDFLIAGCDVKILLADIHAMLDNLKSKFEVVGFRTQYYENCIKAMLANIGVDSENSSFGKIIFIKGSDFQTSSKYVMDLYKLSSITTERDGKKVSNPLLSSLIYPLMQALDEEYLDVDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP9</accession>
    <name>A0A4Q9LVP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1062p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001062">
        <property type="protein sequence ID" value="TBU11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1062p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="18612" checksum="163B3C885C05DB1C" modified="2019-07-31" version="1" fragment="single">KLRKYDLLANYLGLNYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIRSIVLKKIVETIFFDRRRGLESGLNAEVSWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEAEEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT4</accession>
    <name>A0A4Q9LVT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0617p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000617">
        <property type="protein sequence ID" value="TBU12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0617p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="13358" checksum="B1EDA7836EB416A0" modified="2019-07-31" version="1">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTNPCTLAIPEGNRLMALRTIFDSVTADPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA6</accession>
    <name>A0A4Q9LWA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0558p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000558">
        <property type="protein sequence ID" value="TBU13019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0558p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20495" checksum="853172064DDFF442" modified="2019-07-31" version="1">MGHNWLEYFPSNPLLKQAFFETLKSKQSHWKKTSGQSHTVQEIFDNEYAEIRLDIRKKPMSREYDLRANMLGPIYKCIDCVVAKYHMMYLKILQIPMNVEAYIQSIVLKKIVETVSLDRRKWLEASLSVIEGPEIHEQPTSRNYSRTESTKNTFPHYLRWPNHSKRPEKNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC9</accession>
    <name>A0A4Q9LWC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0548p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000548">
        <property type="protein sequence ID" value="TBU13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0548p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020403616" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16780" checksum="D0CE6FF43DD0E627" modified="2019-07-31" version="1">MKQLFILFSIFLRLYCSQNHPLYKENDISLIKESEDSEKSNTSEAVTERLLMIALPIKWTKATHYKFLDWIRILPFKPSSNSNVDTRSNQKGIISGQRDSLSANPLTNSDSLQHGSDVIYGIGVSIAITKYSSAWWQAESEYSNTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWS2</accession>
    <name>A0A4Q9LWS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative Sec24-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0505p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000505">
        <property type="protein sequence ID" value="TBU13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWS2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0505p0020"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="11">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="12">
        <location>
            <begin position="163"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="14">
        <location>
            <begin position="424"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="13">
        <location>
            <begin position="541"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="88112" checksum="5A30388DC3BC9919" modified="2019-07-31" version="1">MTHTYYRSSLKKIPKNNIIIKKSKLPFIINITLQDYNKENIIYSEEDIIRCEKCKTYINPYVEIIPPGHQWKCNMCFSINKVTQPFYRSGDSMGGDGLYNTTSSPYINSSSPYTTNTNTNTNTNTSTFNPLANYSNNKHYNSLELTHTVIDVLASPNYILKSPSPPIYIFIIEASVISFKNGMIDVFIRSVLDNLENVPNVNGRAKFMFMFYNSKLYIIRRGEGEGEGGGSKDIGINKGSNNEEYTNNQEYNTKNTPSLTVISDFSEMPLVMENDFLFSFEEIKNINFNIFKEILLCDNEVLNDLGGVLKFVNFFLEKSGGGGSVLVGMCSVPNIGCGCIDVKDESFLCKNTFYKEIASEFSRNYISISYFLFPNLNMEIPSLSVLSRYTGGVMHYFPNFSCKDELHSCKVYGDMGRFLSMDVGFEGVCRVRMPKECVFKEFYGNFHLKKPDLLSFSNFYACHSFSFEIEICGDLNVNALCVQVACLRTVNEIRKIRILNFCIPVDLKNSVGDFYKNIDFYALVHGYVLKGINNILKNKNEPFEFINKTVKEIYKGYLNNTGKNIGNGKLPEELEEIPLLLLCAYKSVALRTSNYTPMDYKVFYSYLFTVGYPKFIDLLIYPNLIGLHLIYEEIYLNGMDVPVNYDKYRCRLSLDYLEISGFYLLDTGVNIFFFVGSECNNEMVEMLFDSELKSGRINVGIKDNNFSKIVCKMLGMFICGRYLSPNYFYVRDTGESDIYKDIFFSYFLEDSVHGLPSYNEFIKNLRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW2</accession>
    <name>A0A4Q9LWW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0612p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000612">
        <property type="protein sequence ID" value="TBU12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0612p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="701" mass="84076" checksum="27AEECB3E48F3FB2" modified="2019-07-31" version="1">MKSFRHFFYTYATLIHHILFLISQSRERDVILHFVKSHIESSSNSKEIQRKCFCQKKRATTDEEIEFHCIEQMFAESKTTEYKKFVLHDIHRLSLKFEVLDKAKVENSTQQIFLCHHIKKHEFEIFYRFIISYYMFRDDTKIDEFYTILYFLEYFRVKYDNMLKKALMIIFISLSKSKAMKILDLEKMAFHFSKQEIFSHEFFKKISQVFFDLFLPRIESCYRIFSVNEHYLLQKYEMFYTNDRKYLLILKGNCLSSIFRKISSNKTIKNIFIILLNTLDLKYLHLYEVGNNNLKAFIITDKIIISLNTNLNFRNLKRIVMLKPTIQAKKKFSKTLSNIHEFIFYDRSFIITENQIEEEKVFEQLNSIKELINNSQTDKKIQISSFSVKDIGYSEEILSYNPNLYTNLFEGHFLPRKIKIFRFLNLKYKPWEISCSLGYDNRFYNISITFENLNLNKFKATDFNFGKDIRTIIIKDSKIYSEFLADIFSLNRIIKFEIVRSDIIIQENIKFRNDSIKKFIFYAKNNENCPYFYEIINSLINLQEMFFWFPRQTDFNFFAPLNLTIRQLNLKTISFHKNFIEQYEFMLLSNLIPSEKVSLWGKCDPGSIKYLCPNKNYCNVKKLFLFPLSIDESDIKALKNLFKSDPNAEETRKKSSKEQDDAIHAKSKTNTSLILDREPGIIIKEKSNIEEEIKEIIEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY3</accession>
    <name>A0A4Q9LWY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0506p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000506">
        <property type="protein sequence ID" value="TBU13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0506p0030"/>
    <dbReference type="OrthoDB" id="6819241at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="20910" checksum="BBEEF7D162E154D9" modified="2019-07-31" version="1">MKVGNKIKVENKIRVGNKMKVGNKIKVENKIKLENKIRVENKMKVGNKIKVGNKIIFIVILAIGKVETDSRQYLNNREIEYETRKAGLCINDNYKTILRLIVMYGCKTWILTKRNEAIHRRIFGAIRNGKELYVFNPDDRRLPGCTKTRWTDNIQNNLSNLRIDEWKKRHLIVTDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX24</accession>
    <name>A0A4Q9LX24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0494p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000494">
        <property type="protein sequence ID" value="TBU13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX24"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0494p0030"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="17914" checksum="C3B249D20AAF9095" modified="2019-07-31" version="1">MAEQKQDDGTKYVAIRCVGGELPGATLAQKVGPHGVQAKVLGEEIKKATAEYKSLKVNVQLAIKDRKATLEVTPNSSTYILKALREPPRDRKKEKNITHHGNITMVDVVDVARKIQHKSNSKEFSGTIKQVLGTCVSIGCRVDGKSPKEVIREINDGSLKVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB5</accession>
    <name>A0A4Q9LXB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0464p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000464">
        <property type="protein sequence ID" value="TBU13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0464p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7487" checksum="FA1E4B83F98B45BD" modified="2019-07-31" version="1">MLKDSNIYKYRGSDSVDSIRKILGSLSLCVIEGAETHKQLTNFKQLNNEEDSVEKENTKIFTLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK7</accession>
    <name>A0A4Q9LXK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0430p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000430">
        <property type="protein sequence ID" value="TBU13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0430p0050"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="500" mass="59678" checksum="D547ADF1F71587B7" modified="2019-07-31" version="1">MVTKKNRGHVSFIRCDHCSRACPKDKIIKRFQIRNLIEQAAYDDIKAASIYETYEIPKLFSKQQHCVSCACHMRIVRCVKTWDLSIYTVVEFEYDSRYGYKSEMINAYLKPNGFTKETILFPCFFNVKYFNLFKNLLNYQKISEKFNKDFMLKFCCIIDHLLLEFEKGRLEVLFSELFKNCSCFYEFIPKYNFSFYKEISECFPERIRSDKRFSTTFIKFQESNYLLDKMRKSSIPKVNIWKMIKDYYSLRLPLEGIKNLRIYNCEICHIWSLMIHFEALEHILINRSDSTKRIILDFSIFNKFKDTLRILEIYSFESFTNSTNIRFKKLEIIDLGIIENTIGASTNVDFLERIIFNKSISVILNISSAFYFKYLREFTIIQGKIFKESYTSEFERIILIVGEITSQYSLQIVKTEKLRKYNLLARELGLIYKCNIEIISSVVPGDGIVTKYHKMCLKKLQISINRDIYTIHIRMEWKRASIDVIKIAEMHKNRTIYKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP1</accession>
    <name>A0A4Q9LXP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0391p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000391">
        <property type="protein sequence ID" value="TBU13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0391p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="647" mass="77537" checksum="859A591B0979989F" modified="2019-07-31" version="1">MHINLSKEMNVVFNILHDTKETASELMYKEFSTKCLCQIKRDVLNERDESIYIEKMAIRNVNWQYDKYTIKNFERIGFENVIKIIWYSLVKSEEINNFDIEKISFHFSKQDYFSHKMFKKISQEYFKVIKFEMNTINSFFSKKEINDISNKGKGLYTREGKHVLTINNSEFDLFISEKVDVHPKSKSLFLIFLNTLDIRYLHFCDLYINDSKAFCIILENLKKRIDEIVFFKAFIYDETIISLNANLNFVDLEKNIFIYCNIDENMVVFDFLSKINELVFYEDNILSKKYLRHEIKDKENHNIVENIIEILERTYKKSTPEESVRQNKKITEEYENFYLRLLNEKKCKNKQRYIIDKNIKRIEITSSKITSKFRTEILNVNGLARLEINYSDILFESDICVKNKSIKYFKFWKNKGEIFGYFFELLNMMVDLKEVFFMSEETLKLSRSVSQIFYITELNLLNVNRMIDFLKILANNKNFDLTAAYNDILDLECPSDSVKFLFKNYDLSSINELSLYDFSIDKSNLKAFSNLLNLKELNFFRINFENISLSELFCASQEYKIKIMKLKEINISEKDLIFIANLKNLKKLEFERCYIQQKTYIHSIKMLFINEFYIELTYFKRFGQLSEETIQFIKEAFGVKNSEINVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY2</accession>
    <name>A0A4Q9LXY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0361p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000361">
        <property type="protein sequence ID" value="TBU13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0361p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="762" mass="91501" checksum="6275BAB6195087D4" modified="2019-07-31" version="1">MYLNIYLEDLQSISINCCAYSINIEFLSVNETNKADLYSNQVENYFLNKENLEYSENITPRKRIEMKTPKLFTFLYPDDTFLKLGFFEKLINENKTEIQLLVYEKEYFNILYFFTIARNKDKIMMIDLEMFFHILKYLNIMDVDINKNYHEFIKSLVFYVKNFNEEYTRKFGLEKLLDYKRYNSYHILDITKCFLKFNLFSKYNSYLTFHEYNKILFSQSRIISDNLKQYKKFITMQITDCNYIAYTRSVSSIFNSTLKFLCRVLYFDKLYIGLSFIHGQDIDTNMLVCNLPKNIRKIDILASNNISLVDKLYEFGVFTTIKNVKIIQNASLNSFLKRMNYFDQTQMLKFELNRMSFMEINALEKINLPQSIKILKIIICKFSEFRNRTPNHYLLGNIQNLVIDSSSSIEISDDETNFAKLSNDGYYKYLIGADFFFYKNKFNLHDYKDIFKIEKIIRLNLTLLSAKDNFLEDYSFLRAFKSLKNLYLENFKLTNELLKAIVNCKKLVSLYFMTFEYDESIDAMNLNVCNNSIIYIKIKCPKNVLDCRFIYLLSRFTFLQHLIFRDVSFSNKEPEKFDQTKNPIELNLLSSGSAREKLKTLKIKNNPTFANRNTFSILNIYSKYFNLQYLNHLTYEVCSFYKEDIYVFSSFKQLHRLELNVKRRDSISNILKQILRTNIKHTINRMLVQLDKFIDREFLEILYFKKIKILILRIESISETDKKYLNILYNMNFNRLEVYIFKNENVENSISKTRKLIYKNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY19</accession>
    <name>A0A4Q9LY19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0352p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000352">
        <property type="protein sequence ID" value="TBU13723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY19"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0352p0040"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15324" checksum="53629A1D8CED4E8F" modified="2019-07-31" version="1">MVISHGYGRVGKHRKHPGGRGKAGGLKHLKTLFERYHPDHFGKVGIKIFHRNKNAEFSPAINVDKLWSLIPEDVLPEFVGNESVKAPVLDLKRFGYFEVLGRGDLFYKKPMVVLARRFTKQAEEKIVAAGGKCVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY20</accession>
    <name>A0A4Q9LY20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0375p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000375">
        <property type="protein sequence ID" value="TBU13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0375p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="30378" checksum="4EA52F0897FC6E04" modified="2019-07-31" version="1">MNRYILECLKNPKLEYGTVFLFMEKKLPIQYFKEENTYTLSGKNFVLDIKNDISKIFFVEDSYNVHFEYLEFYFNKLLSKKDFFTFFFAFKYFLYFDYSSKNDNNSNILKLHSGLWFCECLFSENPCIIYDIHQLVKMSEKSENRNAFYNIFTHRYEIFYEKYILPVFDKSINAETIDYKEKIKNIYFYNLSGGNYTYPHECIEINLNSKVYKICKNLDVYVGEYKIPELSFLLKCGKGLQESCDIISKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY23</accession>
    <name>A0A4Q9LY23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ThiF-like ubiquitin-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0479p0050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000479">
        <property type="protein sequence ID" value="TBU13286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY23"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0479p0050"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="643"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="789"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="9">
        <location>
            <begin position="881"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="950" mass="106120" checksum="58C4E95C497A2E15" modified="2019-07-31" version="1" fragment="single">MPQNKKTSQKPNNLDESLYSRQLYVLGTDTMSKLMSSTVFIYGMDGLGQEIAKNIILAGIHTLYIYDPLPVHPTDLCTGFYFRTEHIGNRRDFSVLSSLLQLNPYVTIQIHNPYHNCCDGSRLDSCRDNNTNKDMNTNNIDNHTTNTPTPNANLIVCANLPLPLSLHYNTIARKHNTPFISCQIQGLFSQIFTDFGPSFTTYDITGEPLLSGPINDISQEGILTTADNIRHELEDSSVIQIYDIPHLKDIKFKVKVLTPYKVKLEVTGCDKGEGDISNKDIKDNSKDIKDIKEINTNPPTTNPPTNSNTKFHFGIVEGGTFEEVKVPKTFYFQSLSQSLLTPDILTLPHSTPERDLILHKCFLTLNTYMSRNEIEGDSNRDMLDGSNPLDNNPLDTCNNPLDTYNNHLDTNNPLNNTTNNYNTLTLTPLDTNTFLKMYEYEYGNIDKNEKLIKLFCKQCCGSLMPMCSVIGGFVSQEVIKGCCNKYYPLHQFLYFECSMEGDSGVGLESVNDSRIGLEGVNDKYSSVKGVNDSSDILEGVKDSSVVLEGVSYKYSSVKGVNDSSDILEGVKDSRDKYKGVSNSKDSNYHPVNDSINEQQGVSNKDSNYHPVGNTDSNYKGLTNTPTTPNNNTPINRYTPLVTLFGSKYLSILHSLKIFLVGAGAIGCEHLKNLIMCGIGVNGNITVTDMDSIETSNLNRQFLFKKKDVQRMKSEVAVEESLRMNSDYRKVGSDIDSRGGDRDNKDMLDNKNDTIPNHNITIDNSNPNLSSNPDPNPTLTLNKCINNSIVHLPLKVGKETESVFSDTFLTNTSLVVNALDNIEARLYVDKRCITNKIPLFESGTLGTKGNVQVVIPYKTESYSSSRDPPDKSIPLCTIRNFPHCIEHTIEWALSEFKSNFEEKIISISEYIKGDNYRDSKLEGDNDSSSNYKGVSYKDMGQDPVNDSTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE2</accession>
    <name>A0A4Q9LYE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0470p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000470">
        <property type="protein sequence ID" value="TBU13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0470p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="674" mass="81158" checksum="82BB8AC12EDA2D7B" modified="2019-07-31" version="1">MCIKSKNIEILEYIGLNQSNVVQSLEFMSKILSILDKFSTEEITIFMATYEYKDTKIKYKNEEIMSLSEIFRKIPTLKNFTSSETFYDFDINILNDTSKLMTISIDSIEYLSFLRAKIKDRNVEMLCKKYIYSQNIINTTVAIFSIILQINKPLKIYNLEYNKILELICKKCIFDFCMNQPEFRKGIVLFFVKNNLFDISIFKVLKDEFIPFNWFKNVETSNSEGKELQYNDLYSLNYKSKINITKDLDENGIENQDTYFLNSQSKIINNEFIEENDHKTGDLYPPNYKSKIIHKENLNEKNHKSEDLYFLYLKSKIIIKEDINEVIKNKIFSDNILLLIFGKKVDFNLFNSEEYLKYALRWEESEIFEYIFEKYLIFYVKYEIKPKREIYRKKYEIFNEIYKFLNQEIENPPILHKLNYFSLEERNKLLEKYIKLYNINEIIETFFDVEIYSNVLKEYLKLNVYKIAKPINFCIIISRIAYSDVNEDLLMEKITSLTKKEMNKFFTLKISLLPFKKWIFSQETLPKRYIEDFFEEIVDKLDFLESELLKSLNFVSNNFLINIFTVFFKSSFCKSVQASIIIKFLEEINLLKNPHKKFTNFVIESQKYYLNEILTDDFFQKEDIISCKKFLDNIFIYLNYTHNLEISTFYDEILIKLKRWCSYHNEVVTIKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG1</accession>
    <name>A0A4Q9LYG1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chromatin elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0463p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000463">
        <property type="protein sequence ID" value="TBU13337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0463p0030"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="629" mass="71611" checksum="6AE18E714EB03042" modified="2019-07-31" version="1">MPKNKHSEFIDIEAEESSSSSYESTYSTPSSPVATRDWTHFTDQLIKKYQDVDEELEEGEVEEEYVESEMAQQNLLPTKTSPKLWVIKVKPHKEKRILQQLMVKFANSPILSLFCRDNLPGYIYIESYSKQHIQEHIRSRITLVPLEEMVDALSTATDENVVFKSGMYVRIGKGKYKNDIGQVIGVQGPGRTKIRLVPRLPTKKMFDPTEFPNEVFKTKDYFIYKKEIYKNGFLEKVFDSTQLTIIEPSFSEMSMFCENGIMSGERIRVLEGEMTNSVGIVESVSGQELFIRTINNNQTDKNYLKRNSNNLIQVHSSFVKRDFKEGDLVVFEQTPGVILNVTNSTAVVAFNNFTEQKSVKIDFLRLANTVPTIIKNSSVPRQRLKRDPFLYKEVLLQEGEFKGYKGVVKDCYGDTFRVQLNSNLKYVNIGRDKVQKVGGFEGSKNYIFNEKYGGTPGYKTPGHMYGQTPGYKTPGHRYKEKFGETPGYKTPGHRYKDKFGETPGYSTSNKYTGETPGYSTTNKSLGSQTPGYSNKFSNQENNYKGIILKTDDGFDVVEKLYKSTYFTRNGKEFDISDVEYAPPVVFDRCCVVETNEKGIVLSMKGDVCIVRFGNGSVKEVSVDKLAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH2</accession>
    <name>A0A4Q9LYH2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0460p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="28932" checksum="C2C1B42746E56028" modified="2019-07-31" version="1">MLQLLFLHSKIIFRYRSDCIILALFYFCTLLAQTSVILIFQVSDTRVDSTETNFMLNKITSEKEIMNKIEQTNIRTKTNENFVSKKKFINQMTFVINNMEKYFLMFQEFKKLQSNSQKEIIFILNSIKYSEFVNFDYYIKTYYLPPENFCFDHFHSMLYILNYFKVEFDLNCKNIIRNLLFNLNYIINTFENFLNEIKIKFIIEDYFSFKLFNLVFEEYCFLILNEKNYYMIFFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL0</accession>
    <name>A0A4Q9LYL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0314p0030</name>
        <name evidence="2" type="ORF">CWI38_0335p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000335">
        <property type="protein sequence ID" value="TBU13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000314">
        <property type="protein sequence ID" value="TBU15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0314p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0335p0030"/>
    <dbReference type="OrthoDB" id="2192753at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="13947" checksum="735AB194A68DB0B1" modified="2019-07-31" version="1">MDYDIPYLCPILVPKLCFTTFLCPCLVSSIVYARIFKNTNFSLFALICIPFSAYGIRRFVQNKLKYQEDHEVSILKSCFYCSSLVQDIHEMEIRRIGIYKYYDEPLVDESTEECENIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN1</accession>
    <name>A0A4Q9LYN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C13-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0308p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000308">
        <property type="protein sequence ID" value="TBU15712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0308p0020"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU15712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="31406" checksum="310C77F0CF606C70" modified="2019-07-31" version="1">MKYKIFFLIKYVLTKNIAILINGSRYFHNYRHTSNILAFYFALKQNGFEDTEILMVSYEDITKDPRNIYDKIYFNPKKHFEKIDIIPFNLTINNILNVLYCKNSKIYDLDETSNVFIYMCGHGGEGYIKLCNREYLLYPDIKKAIMYLCKRVGKVLFINDTCQAESIFDGLYQIDNLYLVASSERNEPSISTQNCSIIGPSLIDNFPYKFLDIIDNCIDLDLNVFFDLFDFESVMSHVIHSNDSRFKVKDFFVQRNENELFLFMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ9</accession>
    <name>A0A4Q9LYQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0584p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000584">
        <property type="protein sequence ID" value="TBU12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0584p0020"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="37445" checksum="D284F2A4F0EC0A66" modified="2019-07-31" version="1">MYDLCKKYVIRKEIRDMTEKEWMKYKDALLKVYKEGLIEEITKIHVFVDDYAHNNDRFLPWHRMFLLYFESILQFISNDDSLCVPYWDWTLDAENPSDSIIFSEKYLGFNECLKLYFPSEHCLKRKEGIINPFYNKSKINKLLKIKKDYKEFREALEIVPHALVHAFVGGEDGDMSMMYSTNDPIFWHHHSFIDYIWHKKQKNDKNYNYNGKDNKGNKVSKEDILFPFNKKVKDILKLEDCCVKYKEYNHVKIQTYDDLNIYRLPESYIKRHKYSLNKVRKIENSLQEIKRQSRLKKIFIFLKKLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT9</accession>
    <name>A0A4Q9LYT9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0531p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000531">
        <property type="protein sequence ID" value="TBU13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0531p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27748" checksum="098A423EC898A085" modified="2019-07-31" version="1">MFSFYVCPVLKFIFSFVRSSKRGDELENDQSILLGSESVCHLQDTVSLVRDNSMNKKKFHFRRKKRVKRKRSLSKSDLNFTDEETSLNGKISDIISIINDIRKEIKDGSDIKSLLIKLQELITSIFGCREGFIDKKINLNIICPDLQKSIEDHNKKLNTIETDCKAIYEKIRIINAKIYENNLKNEQELIELLQKFLGYTNKMILVFEKLQNCFAEYRMIKKSITITESFKNVQNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV2</accession>
    <name>A0A4Q9LYV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0287p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000287">
        <property type="protein sequence ID" value="TBU17347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0287p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="498" mass="56925" checksum="1384F536672C8D54" modified="2019-07-31" version="1">MGRKKNVSSEILKNTKIKAANDADEVKKCDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTNPCTLAIPEGNRLMALQTIFDSVTTDPKEWPRIVFFAVQTRFERMPRNGWTELYRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISMNEIGKVVVRTRKHPNKLVDSKVLDLINRVVGEYAGAHVPESISEAAYIMQAAQICYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSGALVKKNESLNVYEKKITMYESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIQKLTTLHKYLYDTVKVICLEGTLKDIGFTAGLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY5</accession>
    <name>A0A4Q9LYY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0512p0030</name>
        <name evidence="4" type="ORF">CWI38_0277p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000512">
        <property type="protein sequence ID" value="TBU02302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000277">
        <property type="protein sequence ID" value="TBU17635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0512p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0277p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033829804" evidence="2">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU17635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="207" mass="24268" checksum="88D2514E04965F1D" modified="2019-07-31" version="1">MEIFYLYLYIVVAVCGIKTNEHKNGNSTENVEILCGFGTDGYIVSQEERHRQINHPRFNDMCIITFLSEANPVVLVDQYKKYRFLEAEKNHTDLYESSDNYTEINQSSKNHTAKINSSKNNSDKIQSSRNSNKIQSSNNYSKKKNVNESYFDELQQEENHSDEIHFKEDPVYEIQSDEKHSDEIQFKNDDIDEIQSEEYSFDETNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY9</accession>
    <name>A0A4Q9LYY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0409p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000409">
        <property type="protein sequence ID" value="TBU13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0409p0010"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17401" checksum="C257F6141E964BFB" modified="2019-07-31" version="1">MSSRNFLVQPSELNHIIRLFNTNINGTSLVTHALTKIKGIGRRYADAAVKMANIDPSKRAGELNNEELNALQNVITDPLSFGIPEWFLNHQKDYTDGTTSHLIGNQLDADIRLLIERGKKIKNVRVCRLAAGLKVRGQRTKSNGRRGRTVGVSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD6</accession>
    <name>A0A4Q9LZD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0223p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000223">
        <property type="protein sequence ID" value="TBU18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0223p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27343" checksum="FB64F32F552CB1BD" modified="2019-07-31" version="1">MSFWRTKTFRISTIIVLGLIIVGLLIGGIGYYKATNAIKDFERDFKNVSKTEQFKNHLSKVKNANIAFFLILEGFKIFWIVDPKDNIIKIFKKNEALGTDKTPKQFQINYSMDLQKIEPKIGLKFKRKHSIKDIYNAVKIFDNELNRQLNFKQRTFLVLEIIDVKNIIVYKLHMKHGENTFLGVSTSLTFESLKINDEVYYVSDFITYIAEKVYKEATTDAILNEFKKIFNINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI9</accession>
    <name>A0A4Q9LZI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0350p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000350">
        <property type="protein sequence ID" value="TBU13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0350p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="717" mass="84172" checksum="380C5732F4D98FB3" modified="2019-07-31" version="1">MFLISSLYFSFSFCIDYLPIAFKLNLNAHLLVFLDGIEYNVFDAYFDKDGIYERINMENTEILVKSETSRHIEKVIVLYINYEDAFKVRFEFFDSYLKHNIFIQSPIYLDEIISMKLFLFFLNSVTRFHIRKLQKRISFYQFIDILQFISFLIPKTEGDYSIIVFCLLKRGISGQLTTHKIEALCCICRTTFNDIFLIRLLIHFFESLEIAMLFKNNEITLKNNKFASYNYAQRRQNISYFQSFDLSIDISILKPLLRYLNNKDSIRVFDLLLTINNITIITLTNYYLANDLYICLYDSSCARCSITTRFFSLLNESIYKNYLKKLVMHDIEVMEENYKFLNDFQNLESLNISYKTFKEHSFISISHSFGRLKEYKIVNTKISAETLCLIFNSNLEILELKMSEISCDGFNLDFEYPIFAKCNKLYIFECRFDISFLKLLWKFSSLECISIVDSFFGVSNNYPKPEISFFKNLKNVSIKNVNLSISRCFFSNLHESCGLKVLNVDIGFHLLPHFIKLLASNIANTVEELFVSSKMLHETVFSKILKFPNLKILDLVDFKIPKESLLQLYSSSASKTLEFFRICDYSIHSKEYGIFSRVSNLKSLHLHSSILYSKLHLIFGTLSQDRIIECIHIENSNVSESDIRYISTLKIRSLILINTQSGLLKVFYNLKNEIIKETLVNLNIAFEEDATIVEKNIFLDFFFGLKSLIINNYECIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL0</accession>
    <name>A0A4Q9LZL0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0344p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000344">
        <property type="protein sequence ID" value="TBU13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0344p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="94798" checksum="2B29AA8CF81BD302" modified="2019-07-31" version="1">MNSKSESGIYHAASEEIEVYERNQFCINKTPTYVRKNEASEDNYTCNKRFKVSENVETISNIKITSMYYDLSNNLFQKSDTHQEKPVISKSSEGNRWCEDNIENSVNKNSFLFQNPSPILIFEYSSSYMIRSKYFDGLKFSEFTEIHLNIKDITKSNIDIIMCKECLNILCYGLNYCILGLNNENFLDFIWFFHDLSCYSESDALDIFYKNLLPFLFSYIADESSLNVFNMQDSDFLKFRNIFWPFLIAYYDTIDIYFDLNTKELMFIEKKGIRKFNLFGLDSTEEIVIRTTPKALSLMHIHHIHNRQYFLWRLISSFRIYGIRISENDKYYSEYKDSEISWDSSIYSLEVYGMQSSFCSVFTIVEQKGNEIKLIEFEKFHLTDTDVSFLYSNENLESLIVVRCNMEKLANFLRTTVKSFFKLRILQIIGFNLKNWFFDTLYAMNIEILDLSCCRCIESSNKCTNRKMGRLKEFRMNYSDLNHDIIESIMECGSLDVLYIQKINFSKFKGFKNSVNWQKSYRILDISGCILINSLLEFFSTDIKCEILILEYFCNLFDLIKILDQKSLHSSTKNLSLSKNSISYKVFKVLDKFENLEFLNISNLDKESIYFKISDVDFPTLSLDIDSDRMLDEKKTKTILELPPSYRKERNPSNFDFKTGFLECLCATGLSTSLRGINLSKNELDSANILRIEWLVNLNYLIVSFNDKIFSGFLKEYGALKFSNLETLILVSTNINNDIYHFVMTLPLLRNFETRECKFVEDILVSNLNLYPMVLEKIVFTNTIYSSYFKSVLEEMHAKRINVIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZM2</accession>
    <name>A0A4Q9LZM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0203p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000203">
        <property type="protein sequence ID" value="TBU19780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0203p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="14410" checksum="4D7179B546EDCF4E" modified="2019-07-31" version="1">MEKMLDEEGYSTSENIRKVFYDLASIYGKLFQEKGYCDFIQNPFSLNFKLWFRENMAGLRRMLLRNIVPKYFDIRNFLTSCNIFLNYICKVTLNPDITPIGFEDILSEKIFRFLQVKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP0</accession>
    <name>A0A4Q9LZP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0305p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000305">
        <property type="protein sequence ID" value="TBU15842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0305p0030"/>
    <dbReference type="OrthoDB" id="2189782at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="20193" checksum="2113ABD4E1A5F618" modified="2019-07-31" version="1">MNIKVKVYIYLLILILVTYYHFKENFNQEIEKEKIEMKKYFNEKVRKLNTNFVLENDNFKRIRVKIVKSYNRTNPELFIEYYNLIKIMINNLEYFNKKEIKKLLNGNFTEEKYFLAKKRIVYLKNNIDSFSKTIFLVYSWEYNLGIFLPVFLPILINVKRLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M050</accession>
    <name>A0A4Q9M050_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0160p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000160">
        <property type="protein sequence ID" value="TBU19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0160p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17030" checksum="5D73B350DF30618C" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVTSSVEVSACEPSYDMTSPCALAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRASRYYNEKFGCTETLEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M052</accession>
    <name>A0A4Q9M052_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0163p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000163">
        <property type="protein sequence ID" value="TBU19959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M052"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0163p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6092" checksum="F533A4374B91897E" modified="2019-07-31" version="1">MPNRTNQHLLYNKPVTTKMMEPTININQDGFERRNGSSKEVDENTYENGKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B6</accession>
    <name>A0A4Q9M0B6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0154p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000154">
        <property type="protein sequence ID" value="TBU20005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9M0B6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0154p0010"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1293" mass="146335" checksum="6EAB9A7FCBBBAA03" modified="2019-07-31" version="1" fragment="single">MNIGRKQISPTEFDNLWKTIEREFTKLTTHSLCNSVLVYNCVYDICTCVNNKYDEKLYWRIGDFLYSQARNHRTIIMQAIGNRHERVDKGVDRINSGIANGINNGINNGIGSSTYTNTCTNTSNNNDIPYTTNPCSNPYTNTTTNPYTNTTNNPNPNLTLNTRINNLSTNTPTYTTNPPYTTNPYTTNPTYTTNPPYTTNPTNPYTTNPPYTTNPTYIPNTTNNNNHYIPPYTTNPTYTTTINTPYIPHFHAHNILQSFSHQFSLFKRNTLSISQMCNFLNETLVSSKTARKIEDFAFLLWERCVIQHIDINFIVNLLISCIDTPTYIRNILLCFKSVIFDINNPLLYYKEVYEERVIKHITCKYSSIGDSKGGSMCGSKGEGVSKGEGYEGVSRGGSMSEGLEGVSNSVDNYRGVSNSIDKQQGVSSKEGSKEDTKLEGDNDSTTKQQGDNISTTKQQGVNISTNKQQGVNNLSNTLHPVNNTANNTLHPVNNLSNTLHPLNNTSTKHPLNNTPHTTFLNYLTYVYNTFKYERSRRHLLFLEESYNELDISLEKVLIIKEECYIKEEIYKVLEGVLGGGSWCDLEGDLEGDLEGDSNNSYKDSNSSNSNNNSNKSNKDSNNSNNSNNSNNSSKDSNKSNNSNNSSKDSNNSRVNNNPNNNPYTNTNNPYTNTNNNPTNNPYNNPYTITNNNNNTPTPNNNILLTVYNILSYISPYSLSLLLTTYSIYINNILKLNIKNIFKIKNNLLFFNNLYNTYDSNISVIMYGMKDDSEFKEIFNKAYSEYINRDYVGGSNRLEYKLEDRLEDRLDNTNTTNNNIHNTYTNTTNTYTNTNTNTNTTNHPYNHHTNTTTNTLTSRISLYTHYVLKYSTTFSKDISNILTILPLIYKKEEFSISYLYFYSKRLLNYNCNYFKEESVLLKVRDVIGDEVYRKGVRMYKDIRMSIEFNKEVWRDMGVGLGGEGGLEGGLEGEGEGKEGKEGKEGSGSGKEGSVLDGKVGDRGLPKTNHNLIGIGTIGSISDNPIRSNYNPNPNTNPNPNPDNPISSNPLPKTNHNLISISTIDSISDNPIRSNYNPNINNTNPNPNINNTNPNPNINNTNPNPNPNPNPNTCINNTNPNPNPNQHTNPNITNNPTFFLSILTNCIWPFNYNTLLPSYTDMLKGNMKKWLENIKKKYKKKYKNRKLLFISDKGYIECIVYSNKEYKVRMSVYEYLLIEILIEKGSIKVEEYIIKGGSDVSDVSVLDNSNNIKDILDSNNIKDNKDTKDNKDTKDNRDTKDNKDTNNLHTTNTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F8</accession>
    <name>A0A4Q9M0F8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0134p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0040"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="437"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1119" mass="128178" checksum="C943AA9EA7641561" modified="2019-07-31" version="1">MIENIRNEKIKAVNNLVNSAGEILMCDVDTTTSTDFHNTTHQPPSSSCQTSPVCLVDTIPSSSGTDATAFGPANGMTNLNTDVILEGNRLMVLHSILDSVTVVKQEWPISAILAVQKRFERMPRHGWPATLRYYNEKFSCTLDIDAFKKLARNEAEREIRQEENGERRRIATCLTESCTLTDTTEYINLRDKFLSKIKEISMKEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKDRKQEMLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVEFEHVVSRDEIVSFWSTQWNKNAKLVTYDDYLIPFVSDNHPTTYPLLDEFINIINWLPNWKAAGIDKLTSLHKYLYDIMKVICLEGKPQADWFYCKLSGSDYRPITCMSNFYKLTTKCVTKVVQLEVERRGLLAENQLGAQALLNIALNKEYGNNLIATWIDIIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKATVQTDAESHSTNHLLFIDDLKLFAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCVSVYKYLGIIEDSRGIPTRSSFQEVQSKLISRVERLCHTRLNAKKLFSAINQHAISLINHHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGPHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLIEEVAKKCLKEDQLAKLYNEIEKRNLHSKLYNARKNELVSVSDSSRWLKKGNIRPRNEAVFCYIQDRNVLWGADGMCPHSGKSGKTVDHLATRCEKMLGHDYTRQHNEVVRCLHSLSLNRYKFKSSKRIRSRPHAEIRVDTRINTDVEIGNNRPDIFFLDKKKNKITLIEVGITSQDSLQIYDLLANELGLIYKCNVEIIPYVMTWVSIVTKYHKPHLKRLEIPMNKTVETISFDRRRGLESGLNAEESWERASMGGDGAKNFKPKNNTPLISEGETTLEEPTTNINEESDLEEETTVIKEVKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I4</accession>
    <name>A0A4Q9M0I4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0402p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000402">
        <property type="protein sequence ID" value="TBU13535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0I4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0402p0020"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="635" mass="75331" checksum="7306DC457B987AC5" modified="2019-07-31" version="1">MEIFGVSKTYIYGLIKNNTLTIPHKQCPFETEFCISQPIPLLFDEKYKIFYKNKIFNSYVLSEEENVYLLYSVDNKTTMVDKKVILESNTIYTFNITNENEFTRRVELYENNEMFPGIVLKGQVFNDTVMTKYGNGKCIFLDNHPNQKIISVLLYKISGKTYNFIEKVESKDKKHKRIKKAHFLDGSEFKVVAECKNFYLVEKERIRGILLKDMIKNYLNDFVKIKVKDQEWGYVFTRYEIGTSKSKNTELYEGMVGKGVIAKICNFGAIVSVNGFKGRLVVSEISSNYIKNWKSHLENIISEKNELTGIIYNVDFEKNRFDFSLKKYELQEKENELNSGIKLQVPFNDKQNIKETEIEVKINEKNKDLSLKSEENKKVDFCTETKRDILKTEEDYLMEIKNMPKSALPIIKYISFKIERNEDVREFYKEFIKKMEGKEKMDLCVSYINYLIFINEENIINEIKRCYTICDKSKNIDFIDIVIQNIKEIKNDLLKLECFKYYFKIKETNKSFKILVEFLLKNGKIEEGFEIIKKNINYNSIGIDLLYKFKTKDLRVRIENLVCGVDGWVSYLKNEWNDIEYVRRLFQRVVDMDWKIKEIVIFYKLWIEFEEENGGDVEVVKSIAREHAERLKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N1</accession>
    <name>A0A4Q9M0N1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0343p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000343">
        <property type="protein sequence ID" value="TBU13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0343p0020"/>
    <dbReference type="OrthoDB" id="2192581at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="20226" checksum="82BEE92E332B9FEF" modified="2019-07-31" version="1">MIKLIKNGDIVFEIQEDFVDPLTFDSYPQIIDEYIKNEKEQIFAMLLCTKKKFVYLSESIINLRYDKCILGEPLTVYLLDDPISRLSVTDIEYYILKNKIDGVNFIAVYLCNEVELYTYSEFRTIVFKPESPRYVYLVLKIGVMILLLFFAIMFISTIFIFIYLNYFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V5</accession>
    <name>A0A4Q9M0V5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0097p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020760262" evidence="1">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="537" mass="60929" checksum="46DD99195BACEF7E" modified="2019-07-31" version="1">MQKPAWHLYILLFILDRAFAASAFEQHDGRELVVTSPMITESVNSTQACVRKKPYKQRRNRYSDSERVYGSLYRNVMPFNESFSSFRTRLRINDGESYRPVKNNSRKFFVTKPKSFVSKFSLSNKSTLGQSLQTKNATLSSSLPEPISCQNIKCDKAEQNFSVPIGNRFSRIPLIRKNGAQENRSSDSNASESTIPCDICPKLKKGIPLYANASYSQRPPPPMFSKPDQDIPPSFTGPPPPMFLQFIQDNPSSFTQPPPPMFPKPDHDIPLSFTEPPPMFVKMDHNIRANYSSPNTFCSQSSHGILLNSHAQPRMFPKSFHNNTRNFTQPPPIYSRLDQNIPSNFTEPPPLCSRLENDMSLNFTEPPPIVPHFSQNNPKYFTEPPPLISQSCHNIAPDFTEPPPIYSRPDNNIPLNFTEPPIGSQLCENIPLNFTKPPPIYSRLDKNFPLDFTQPPPICSGLDHNIPLVLINPPPLFSQSSNNVPLCFTEPPPIYFRLENYIPPNFRELPPSNFQLHPNPSGILFDHLPSVNQIDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V8</accession>
    <name>A0A4Q9M0V8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0094p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000094">
        <property type="protein sequence ID" value="TBU20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0094p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="30487" checksum="427D19CF631EE14E" modified="2019-07-31" version="1">MRRYIPETLYFLDTVSETKTTHEPISKSIPESSTLHKPIPKSIPESSTVHKPIPKYIPEFNTVHEHIPQTIPETTPATVPLPVFDKKNLRKSPKNQNQKLPLSSLHIKPENSLQRPSNLKPKKENNVNKRENITRKDEDKNQETQKLNPPKKRHNLMHQQKRTRIKITPRKFFILKPRKPTNNDISEENRLILHSILDYVYKGLERMRRNIWSVISSYYNEKVGCTLEIDVFKKVTQKEAEKEMKQEENGEKLIIYISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X3</accession>
    <name>A0A4Q9M0X3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0365p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000365">
        <property type="protein sequence ID" value="TBU13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0365p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="316"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="384" mass="44783" checksum="3695AEFB92A1313B" modified="2019-07-31" version="1">MDIYNEIMKLTAIYSFYDSNFEEKLLNISENDTKFMFLNRNTHSNNIYQETKKKIHKILKIFSKKQTAVNKSEADKNTIFYEPSDVDENTVIDINTDIDMNTIIDEQRNLATNTTTDKNTNLEVNTITDKNNDLSNCTDKNSEEILNTNTNRNLDALRNSNTNKNTIKQTTNNIITDKKIFNSVFNKILNKLKKPKRLISTTKTPTDFNTFKILKTLKHDNMYFRAQTFYEIVTNTKPESIQQTTHLDFTQDCIFCQRTFKIEEIDSHIKQELESINSKNKELESTDSKNQEIESINNQTTNSTEPLEIQIKVFFISLKLPNINTDNISITLKKPVTVYKLKQKIFEITNLSISKQKILIDTNVLRNSDLIENNIVFLKLKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M157</accession>
    <name>A0A4Q9M157_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0078p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000078">
        <property type="protein sequence ID" value="TBU20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M157"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0078p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="328" mass="38861" checksum="6AF70ABDFACDBBA7" modified="2019-07-31" version="1">MGCRFKFLKKKLRCMKVRKQFQKYAIFELVESEHLVNSEEIINKNKSATNDMCCEDFSTLHEGIIEDTKSNQTRSSFEEVQSKLISRVEKYSDFSKFDDVVPGVLVKNKKHLRPACKERLYLYRTELGRELHSLEQRSEHMLNSKDKNTNKMHFSPIKNLLKAKYRLKEELLSVCDSSRWLKKEKIWPSLSTDGIYQHYNKSVPKNSVEAISFDRLRRLDSRRNVEEREKHVEPTPFTTANYQARWLEPKISINEEFMIEENIEKCENCSEFITNIDHMEEIKVGPCEEELGRISKRLIKKMCYQKNMLSLLMTLNETVNTKKIINIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M158</accession>
    <name>A0A4Q9M158_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0003p0070</name>
        <name evidence="3" type="ORF">CWI38_0073p0020</name>
        <name evidence="2" type="ORF">CWI38_0238p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000003">
        <property type="protein sequence ID" value="TBU05534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000238">
        <property type="protein sequence ID" value="TBU18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000073">
        <property type="protein sequence ID" value="TBU20420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M158"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0003p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0073p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0238p0030"/>
    <dbReference type="OrthoDB" id="2190924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="219" mass="25803" checksum="0522F817B1BC866D" modified="2019-07-31" version="1">MDILLKRPYHMDDRIRKLKKMRIFDLIEVSKFGHGSFIRKNKESRSSTIIDINITEAHKLKKDADKIIKNDHNEAVKLYVKSLFRYIRGFVEVENEKSCLEAIKGWKSLCMFITSICSLMNVESDSKYLAMFQYVLYIVKYHYLALESSIVLRKVKGTKDVNFNKDFLYFLTEYTSLHEISSLSRIKNFNLVSVKNLEEFVKSDLEFIVGENDFHTILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M191</accession>
    <name>A0A4Q9M191_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0313p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000313">
        <property type="protein sequence ID" value="TBU15321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M191"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0313p0040"/>
    <dbReference type="OrthoDB" id="2190938at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="43649" checksum="82BEFE581DA72AE5" modified="2019-07-31" version="1">MDEINDLYNFFNLFESENLNGNDFLSYFLQYDGIQTLKYLNPKFDFVKEIFQTKITNKSLNIHKFLEILILLERKHLQLFSNDPEFVLKIIYKFTNQELKEILLNIYKITPIIIEILKVLDDSNDLNRFLINFYIFLQTTKMDFKEAFIYINNHKIDVKILQNSLLNSSFVEIRNLYHLFVNYYPETLTFYSFIDKNNRELIFENPLFLLSLLNTNSCNTTKRNNKLNCFNYKLIRTYIDCINIYLQQTKKDTKNMDILLKTIIFYKILNFKNICCRKLGYKKIIHPLIIECPILVNIIVSRKFNENLMKEIIDFVPSFHISFDISLKFVQNSIFHKNLCNFLLQKYPVPENIEKAKKYKIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L7</accession>
    <name>A0A4Q9M1L7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0054p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000054">
        <property type="protein sequence ID" value="TBU20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0054p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6280" checksum="96A9309035AC29AE" modified="2019-07-31" version="1">MYIKEPIRHQSAQLYILPFSLDSIPFTSQKVLIPHKVELVLGLDIFAEGIVIPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V8</accession>
    <name>A0A4Q9M1V8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0030p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0040"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="163" mass="19425" checksum="691A16ADF6B5E7A6" modified="2019-07-31" version="1">MIENKEGKYKRNEVDFPHPVENLKFIIYYRHVLVPLCLRFKESLYLPGTKDRKYIYSVEPKKETNITQLFNCFENSKGALEIKIKLPKIENTRKIKASAGFKTCRSFVEIEKRKLHSKLYNAKKMRLYVFSTSRNAQRKGIIKQNDELSFCYIKDINVFCRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M278</accession>
    <name>A0A4Q9M278_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0022p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M278"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0050"/>
    <dbReference type="OrthoDB" id="2191859at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="17010" checksum="7E842918E5DFCE7E" modified="2019-07-31" version="1">MKKVKSTEILIKRKSITKRKRHPLSVKETNISYETIPNKEKYNEENHKYNCTEDKENFYEGKENFYQDKENINEDKTNNNNYNNKNINYKSEKSIDAETINSSIKIETPKRKIIILTPNAYCEIKGSPEYKRYQCVRKIDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E7</accession>
    <name>A0A4Q9M2E7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0119p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="299" mass="35529" checksum="D9B7C1511CDA1910" modified="2019-07-31" version="1" fragment="single">EPNCNQRHVFTYKKGNFINFDLLNQILQSNTNENSQQCGIIESDFELSYFLKLSKDILEISDNLNNFKFKCMLTVLKCLKAVKHKNNVKLLQAFICTDLVFKDLSNSKNNYHSSEFLLELNSSIGKNIEFLSLKNLLVQNDSLALLLKKKEELDGLVLHDVKTVENFRFIDECLNLNEKIDYVDFENLILKLGYGSQNFIDEFIKLKSSIYISYLSLDLNYYSMTEEFCRSLMLFEELETQKLYDYKVKEYTESFFIYTIERMKYLEDLIIPRSSYEVTDDFKFYLQNWEIRTFHLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M8</accession>
    <name>A0A4Q9M2M8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit Spt3 of histone acetyltransferase PCAF/SAGA complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0263p0020</name>
        <name evidence="8" type="ORF">CWI38_0071p0060</name>
        <name evidence="7" type="ORF">CWI38_0343p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000263">
        <property type="protein sequence ID" value="TBU03628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000343">
        <property type="protein sequence ID" value="TBU13762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2M8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0263p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0343p0030"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU03628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="235" mass="28371" checksum="BD3B084D368EE428" modified="2019-07-31" version="1">MFYDTEIQSMMFTFGEVKNTNHETIEYIESIIRSNIKSLLSKSRKVQILRKGKYLSVEDICFVLRRKVYMVNRILQFLAFRETRKKINEESVSLYEEKNCEKMEFDWFNHKSEVKDKELIERLRIIDEVTQFMDKEEYLNFCECRQASFTYRKYKKFKEFIEFSNLKDDVIDILGYICYEMVYTLTVNAFKTKKNFKFNKFAKKDLFNFEQSFSLSVKDINAGLFLILKENGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2W3</accession>
    <name>A0A4Q9M2W3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0057p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2W3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0070"/>
    <dbReference type="OrthoDB" id="2186513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="28086" checksum="2BF0DEF9E105E22F" modified="2019-07-31" version="1">MISIYDGLCRSKEINDQNDQYSWILNVIDTHTKHLWCFKRINKTSKLVRDALKFLFDNLGVPVAIQSDNGREFKNTLLEAFSTDHNIKIILERPRNPKAQGERRNYSKQGEECGFNILIMLFVHITEQYIEASIIMPSIDIDPDIVLVEENAADTQWILEIASDSKIRSDQQSNEFKKYLSIGDQVLIKKNLDMNTKTKRAPSDSFYDNSVFTVTAILMNNMIEVKNNDSDTKTVFRSVIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2W4</accession>
    <name>A0A4Q9M2W4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0145p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000145">
        <property type="protein sequence ID" value="TBU20032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2W4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0145p0050"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="443"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="842" mass="95987" checksum="594B9C05056A7AD6" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANNGDEVKRSYISKQKCKLHLPAISLPSSSYTTITPPPPSQTCSKMQNSGLYTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSNEKFVCGLDIDAFKTLAQNEAEREIRQEENGERRRITTCLTEPSTLIDTTEYINLRDIFLSKIKEISENEIGKVVVRTQKLPILDLINRIIGEYADYYVPMTITAVARIIQAAQVCYDELTRKEKPRSAWKENIESKISKLVLSKNLLEKARRQEKLSTSETKSLKKIMGEFSLNLSSVTDHSGALVKKNKSLNIYEKKITMYVGRKQFRKENRMFELFRGRFYRGLSEHVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFISDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTPQADWLYCGLTYLILKGIPRRGSDYRPITFVQLEVERRGLLAENQLGAVRGVQGSKEQALLNIALNKEYGNNLMATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIERGILQEDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFVDDLKLPAKESSTLSAMTGEAKEFFRGDWSATNYTCCEDTATLLEGVSVNKYLGIIEDSRGIPTLERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEDAHLAKLYNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3G2</accession>
    <name>A0A4Q9M3G2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0051p0030</name>
        <name evidence="4" type="ORF">CWI38_0063p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000063">
        <property type="protein sequence ID" value="TBU20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3G2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3G2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0063p0040"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="47475" checksum="2C3F1A23D99597D0" modified="2019-07-31" version="1">MESKENIKISKIPTHLPKSNILVLIWQDVGSLYSIFGDHKKSIHSYERALQQNERNAIIWYKICVEYIILSNYELAIKNSYRLKEFDSNGLYFNTIIGHIYLKKGDIKKSYLSFEAAVLSKNEIDPFLAYSIGLFYESVGLFDIALKLFSKSLKKYFYHDFIVDLVYRTGVMVKVTNSGYSIRVFSVLLRERFYSRLEKKSIKIQIAHLLVLIGKYKDALDLITDILKIDQRYIFALRLRCYIFYKMNDLVNAEHSCVFTIRDLGVGDAYIWYILGLCKRESGNFEAALDHLVMSSRKDTNNWWLWNTLGILYSKIGQYSEAEKSFNSAIKTNPLFSEADYNLNILRTGNMASGDMIDLFADISETSFLSAPAVFDYPTHYHLRYKYYNGSNKVLTEYMPFESYFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H2</accession>
    <name>A0A4Q9M3H2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0138p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000138">
        <property type="protein sequence ID" value="TBU20066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0138p0030"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="461" mass="55154" checksum="57A88B2587531C9A" modified="2019-07-31" version="1">MDRIENFLNKRVQKNKRRVTYKGKKYEITKEEVKKVRLVRNNYCISSLNMYEPLSTKFSGEKLENGIFLETKNSKNKLCRFKKMEYYLRERYEEEEEIKDIWEEDSYQVNIDDINLNVFNKEQYDNFDDLKLDKENLEVILETLHRKYFVPFKKIIPISQLIPKKEKVNADFTSEILKIYNFDHELDSCYFDNTFSFSCVVKEFTMYIYYLRNLSLIFTKRFETKIRKILILRNGIICVLLTNEIILINNMSNIKFQNIENENILKININESILDFYFDENQNKIFLIGKKNLFGFDMQNYAIERILTVKGHRLVSINMIKDYLLIISSTIDIKIVDVSNKKNTGTLVSSFPHAIFIKILNSKYIFCANNNFEIHVFEIENVKNNKTIKFDSSIYDLAVNSFLNLFCVCFENEMVIFEIKMEKTFIITPIKKFKGEYRNCSFYEECSLIYCRYEDKIIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5W2</accession>
    <name>A0A4Q9M5W2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5W2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="24962" checksum="5288512E96D751AA" modified="2019-07-31" version="1">MFDRDLNRQYEQHCIEFIERIGLKFDIFEKFDKMNNNIEIYLCHHIKKSDFLIFYEFIISYYLPVHEMTIEKFYTILYLLEYFRVEYDNKLRNAVKNIWCSLVESDEMQIFDIENVSFHFSKQDYFSHALYKKISQEYLKLLNNGKERKFLCFIKEKEFYVYDGYKGIFTYDRKHILVINYKFDTFFYKKVVVNHKSQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5W8</accession>
    <name>A0A4Q9M5W8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5W8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0190"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11999" checksum="9AFE5E07CBB8FF8D" modified="2019-07-31" version="1">MHIFPFYSSYTGEININESDLDSNEKVIRGILCKKKKFDNCIPVYRNGKEVYESIYIWYPVDEIKSGFEEKVNLIKCLKENKSEMIISKNKNIKKYFKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX20</accession>
    <name>A0A4V2JX20_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1982p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001982">
        <property type="protein sequence ID" value="TBU10152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX20"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1982p0020"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="21635" checksum="2A76E83053C30E49" modified="2019-07-31" version="1">MDSLIGIKGNDFVLIASDTVTKSSLLLIKDDENKFYKINSHLIMAYSGEQGDSFRNCSFTAEKVKFECLQNQIHATPSVVANVLQKKLHTALRKQPLSTSCLIAGKTPESFSLYQVDTYGAISSSKYFSLGASSYFTYGILDKNYHEGITLEQALSTLQECVNVLKKRFVLDIPTFIVNIVRDSGIESLSLKPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX29</accession>
    <name>A0A4V2JX29_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_1976p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PITK01001976">
        <property type="protein sequence ID" value="TBU10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX29"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1976p0020"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="43565" checksum="EA2BA601646FCB8D" modified="2019-07-31" version="1">MVIFLSFLSRILYLSITYISSLIFTPYDRSTSLADENNIFEFMLRWDALYFNEICKNGYYNEHMTAFLPLYPYMVKEISKIFKISCLSAGILLNNTIFILNSIILYKITSKRYNERMAFLSSIFYIFNPASVIYSSTYSECIFMFLFLIGFYFLENRNFFKSFFFFGLCGMCRSNAVLFNVFVFFLNIKYWLRGLLLINIFFGLVQGYWYLKINPGENIIFIPYSYIQKKYWEQGFLRFYTFKKNIPNIFVGFPFLVFCLIICFRFLKNNFTNILNKSYSNQRMRNTTALVLILVIQCIITILFLHWNMFYRFVSYNPFIYWALVSLYEECKDQMWFLLLMFGYFNFSILYCILFGSYYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX37</accession>
    <name>A0A4V2JX37_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1866p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001866">
        <property type="protein sequence ID" value="TBU10302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX37"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1866p0020"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="26400" checksum="96F21F6B7D68D26A" modified="2019-07-31" version="1">MSEKPVSKLLKLSDHPVSENIKFKEVFEMILEKYEYYRESKKDGNCFYISFIYKLLEISKTISNDIFLNFMKSLEECNETIKSTGIDEISFIDFYERFIEILKDSRNNNFDFENIDQTDFNEIIAYFKILISSILRTNKEIYQPFMLDTTVDNYCKRHVEVFYVETSHIEIEALVKELPISIEIINIEGTKQFFIHRFGNNEFKISILFTPGHFEPIYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD1</accession>
    <name>A0A4V2JXD1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1276p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001276">
        <property type="protein sequence ID" value="TBU11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1276p0020"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="58"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="334" mass="39362" checksum="7F6BDE241973936F" modified="2019-07-31" version="1">MPKIVSCKNTKEKEILTAYLKTVNIMMALIAQKYYGIPKEYIKEYVKDCEACGDCNIKTIQPIYINHITKKYDLFMMDCVDLRRYSDQNDTYSWILYVIDTYTKHLWSFWMIEKNSKLVRDSLKFLFNNFGVSVAIQSDNSREFKNALLEAFLTDVNIKIIHKRPRNSKAKGQVERVNQTIKRWLAKKLHETGGRRWIEHLNKLFVHIIEHYIIQQTNLHLCFSSDNQHNNENEASMIVPAIDIDPDIVLVEENATDTQWILEIASDVHEEFTETVITIIADDLGSERKIRSDVAKDFKKYRERIIESNNSNKPKRDLSIGDQVLIKKRLRYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE2</accession>
    <name>A0A4V2JXE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1214p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001214">
        <property type="protein sequence ID" value="TBU11422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1214p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="369" mass="43798" checksum="D16EA18B90C508FE" modified="2019-07-31" version="1">MHISVATKILLFFFSSYLLKSLLIKWMTNEINRYGQRKSFFQTTYNPKKYTRKVEIKNENLVVYDSFKCIAEIKHEEIPKDSYLFNLFLFHSFKEGNIYDGNIRLDISKDVLRIYSSNYTLSPTYTFLLREKPNLTDKSFLDGIKELESLIIFQETFQRKNENETEETEKDESEKQKPKMPKIPENSDLNKKSPKFEYVNQENEKLLQTLRSLIYLGLNGCFAGRVFVINNNSINLYHQGKSRALIFIPKEYLIEEFKKLKAFEQIQKYFDENIIFLFLPDQIIIRFVSVENDATEYYIALDKRKVLYKPFLIFFNKRIKDVRVEKIILKYYNSCIYTLNVEGSENSFSMIQDALNSEKTSAVKSNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM0</accession>
    <name>A0A4V2JXM0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0822p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000822">
        <property type="protein sequence ID" value="TBU12272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0822p0010"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="87344" checksum="1C99C3373A807BE8" modified="2019-07-31" version="1">MFYNDLHSKIKEIITTNSTQPPNKRESEEAQAYISEKAQEYISEEAQEYISEEAQAYISEEVPDNTQCNIKPHHLFNNTYYLQYVKYTHPTLNESEILSLIKNEEILSVIRSNRNKARIEYDIGHEGCDSDCKRCDNEYNRCDNEYNRCDNKYKRCDRVCNINNNSVYLVSYRKVPQIQLPSYFLTERQKELFKEAFIENGKNFDKIIRYINSNIECKESNLNKFDLPNLSNTNNSNYIGSYNNSSYNNSNININNTINSSYNTCNTINSSYNTCNTINSTCTNNTINSTYNTNINNTINSTYNTNINNTINSTYNTNNTITSNNTYTNPHTLPITPLKIHQGVSYYYDNKKKLKYLMKKKVGRMTDIDIKHIIESTWTYKDKNLFNHFYTIYGKMWHLYGSSIPCKTEKDIKMYYRYYRKYGNVVGGESSGGGDSISVGGSIDVVGGNNHRLDNNCNVYNNCNNTVIEGKPFRDTMDNTYFFCSSDVLSIRMAIKRYKEGCVNNGNEREKPYDFKRIIENICKETYSSIKFNGGEGDENTVVGDIVVEDVIVEGGDKNVIEVIEENKEENKEDIVENKEENKEENKEDIIEHCKNEDKKDLIDDKELNNTNITKTLQHATPRRKRVKRILPVIKRGFIKKISKRDILSKWSINNRQLFAIYFPYFNKNWVMMSEYFSDKKAGDLRIYYRHYYKNLSMNEQKLELSLREVERDLDRESVSDVGVSYCRRESGVVYLDMCGIIFEGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY78</accession>
    <name>A0A4V2JY78_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0130p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000130">
        <property type="protein sequence ID" value="TBU20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0130p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020653445" description="Spindle pole body component" evidence="1">
        <location>
            <begin position="21"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="78737" checksum="EE1BF74BE0B9D648" modified="2019-07-31" version="1">MLRNTYYLFFLLYFVFSSRYHDDMNSHFFKRINENNDYRPLIEYNSEVLNSQNVISLKHPVKSESRDPDIFSYQEASSLSIGSIHETTRMLPSENRFSIHDEESYLISRNCLSAMKPISDRDEMIKETNNRYFPYNRKEIERKNRDYYSHNTHFYSVRKYTLDAYADSQRTEGHVCDLYSRPRRYDRDMRYKSHKNNKSVNKLHIMEDVSSRYTRFPKRYLDFESPFAFMKSPKAYIPQLELKNHRNTEVYHPRLRSFSRMLDTRGKNYAMLVRLQTEFIGFSDITFFVENDFSIDGYFLENEYHSFFDLIDHIFIMEKTFWSQFDSLTMLKYLSEKMHESLLKYDFCNINSPLLSYFPCLINVKYFLKNIIFEDINLVKSSCLWILLLKAANALCNVQPNRVPNDRINVGEVTVEKYKDFDVYNGDKASFCVLKRLYVVFYRIARKIFRISNISREYISMLDYMFNNAMYRNKDIHISRGCHLNFSRVVADCMFRIDPKMISLFILGLEAQKIANIRDHDSLLDINCFLLRIFEGSCHLDIDVFSNFRLFYQNLIESYIDFFEIELLSLYVFRGNSIVKNQLNHIDLIVQILKSKAILLSRYRIETLMEISEALCVIFNHFIKVGLNYELYTKRYIEYSVNYCKGKIEALLRIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK9</accession>
    <name>A0A4V6MVK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1447p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001447">
        <property type="protein sequence ID" value="TBU10982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1447p0010"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="54" mass="6592" checksum="372F8AC457F58973" modified="2019-07-31" version="1" fragment="single">GDFKFAIACYLSVRRKFRKIMEISNEEIIKRLEGKRKFEQIFLYNNDCKNMEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYU3</accession>
    <name>A0A4Q9KYU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1090p0020</name>
        <name evidence="2" type="ORF">CWI38_0427p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001090">
        <property type="protein sequence ID" value="TBU00173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000427">
        <property type="protein sequence ID" value="TBU13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1090p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0427p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="140" mass="16114" checksum="93E6B1085DAFBC3A" modified="2019-07-31" version="1">MPLVIYTLKSPYTHVINIFFPSTPYISTISPIALQKLSTHVYAVPNSPNTKYLEYYATVIYKCDYNTLTVIDKAKRTVIYYSINRNIDGSIKEYVLQNKTPTETTSFNNKTVQNKNLPYLKVQEGEEVIFPEEGEESDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAJ0</accession>
    <name>A0A4Q9LAJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0151p0010</name>
        <name evidence="3" type="ORF">CWI38_0017p0090</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000151">
        <property type="protein sequence ID" value="TBU04325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0151p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="121" mass="13693" checksum="2DFAEF702392A4D7" modified="2019-07-31" version="1">MSSNYGLCHVPLDQMDIFSHNCIMFEANTLYSNDESNRYNNINESNDINEFDLIKESAGKDTFNGINETYGTNKTDGINETQVTEEFISANESDNTTEFNSTNESNNKSITISNNESNFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE45</accession>
    <name>A0A4Q9LE45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2632p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002632">
        <property type="protein sequence ID" value="TBU06154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2632p0010"/>
    <dbReference type="OrthoDB" id="2195620at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="47015" checksum="1A4564E2E324CAA1" modified="2019-07-31" version="1" fragment="single">MKVDDSFDFGIIGTSISGLIQAQKYKNKSIIVLDYQDNYGTTCTKYSDLLLYKNIKNVNIRIGLDTLLIETQPIVVRAFDKIFKFLKKYKLLKCVEFDFVSEHFYVGVDGVWKIVPHSYNEISFCTYLSNKEKRYLARVAEGKCEMYEVEHLFEVGNYKVLFEGITGREYVRGELVKCEVKEVVGCRVGSDEGSNGYGRLFIREMGSLESLNETIKPDNVEIKNGDGYRSGSEDSSSFYSGKEASPITEVVTEFENEKDEVKDEMKDVDNNTGNEKEMQVKEEEKEIVKVDDEKNEAVEVREENEAVKVDEKGVEEMKVEEKVKEEEEKEIVKVDDKGVEEMKVEEKVKEEEEKEIVKVDEEEKEAVKEEEEKESAKVDEKGVEEMKVEEKVKEEEEKEIVKVDDKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LED6</accession>
    <name>A0A4Q9LED6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2598p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002598">
        <property type="protein sequence ID" value="TBU06318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LED6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2598p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="544" mass="63645" checksum="98403C3EBC05826A" modified="2019-07-31" version="1" fragment="single">MPHLINTHIHLLTLSTSQNKEINKIIKQLTFPPTNTSLNNTFINLISIKKYNNEDITQILTLLNEYINRIPYIKRTVTTKYYNNIDANSRDMESEGSRDGDSSRIDINPYTNNPYSNNYTNNYTNNTITNDPYSNPYTNNPYTNNPYTINTVTNNTTINTTINTITNNNHPYQHTPNNNQSNNNTFLSTLTPLILTLKISRFDKDVELTLYIYFKTLYTLFTTKITPSLQKDIFFKFYFFLKEKIVKKILLLQINNLFIKIIPFYFNMFIDNNLYIGYPYLSSIISSMVYGYSGYDNRYSGYDNRYSGYDNISNRDIDNHSNRYIDNNNNYYISNRYIDNNYISNRYNNNYIGNIDNNRIIYNNLTNTISDIHCVKLYFYNNDSISNYLLSYLTPLNTYLLYNNILISNCLLPVNLYPFILLYFDLNYLFKNICFDVFINDISNNTIDTFVRVINDIKEGYRRCSGGYMYVGGVNDSSMYVGGVNDSSMVEGNNNMIGGVNYKDNKQHPVNYKDKEQHPVNYKDKEQHPVIDSNNTLHPVIDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEJ9</accession>
    <name>A0A4Q9LEJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2657p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002657">
        <property type="protein sequence ID" value="TBU06026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2657p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="26644" checksum="4C26AC436A95E700" modified="2019-07-31" version="1" fragment="single">LNRYKFKSSKQIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIYILDKKKNKITHIEVGITSQDLLQIYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLELGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILQPKNITSLILEGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFK9</accession>
    <name>A0A4Q9LFK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2503p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002503">
        <property type="protein sequence ID" value="TBU06813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2503p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11442" checksum="81BFCB9870B693DF" modified="2019-07-31" version="1">MNEEKDELLDKMPEKVISYFYETEILKDADELKECNQRLNELESFHIFKEIKNSEVKKKIESQDPALVKAYMEDLKNNKSTTRKNNKRGKKGMQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG30</accession>
    <name>A0A4Q9LG30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2465p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002465">
        <property type="protein sequence ID" value="TBU07029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2465p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="25455" checksum="CFC51C2899B82479" modified="2019-07-31" version="1" fragment="single">MKLVIIKLISDTFCYLFYDDQEAFIIDLYDDSIIDKLLSSEMNKDFLDEKDIEALNKKNKERKLIFAFFTEPSMEEERIKTYLKTKYGDSTKVFLPEANNKKEVTIKHMKDGTIIKCIKTPGHSLYSKCFFVKLNDNSKAYTAVGNLFSFLGCNVSHIFSKEMYVKKIDKESIVLYKKDEKAKNLAFIKNNKYEISDIISKKSFLKCKDEIMYNPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG81</accession>
    <name>A0A4Q9LG81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2631p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002631">
        <property type="protein sequence ID" value="TBU06161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2631p0010"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="39627" checksum="D743D153CD094756" modified="2019-07-31" version="1">MKVKNLIICLVAASFALVILILTIVFLNPKKHKEESFDVNKNKPSENKLILKEYPVVGLINDKNVCYFNSILQALYSQRKFLGKLFEFKHNEDQKCIIILKEIFDQMLAGKIVNTSKYLEEIISAAGKSKNFIVGQLQDAFDCLGILISQILKELNGNPKTGVFPQKVFKKFHRQNFIVELFYNQGKETITCDFCPFKNAYIRNYYAFVFYFENSIQESIYNRLKTSYFDCFPGSLQNKYHQAKNIFEFIRLPQIFIIKNTRSDIYKKILIDNKMCVQNQNYTFKACIFYINSNHFFTVAVHNGILYEFNDVVVKKLNIESIEDIETHGMPDILIYEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG96</accession>
    <name>A0A4Q9LG96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2455p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002455">
        <property type="protein sequence ID" value="TBU07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2455p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="24580" checksum="D873F4A235C949EB" modified="2019-07-31" version="1">MLSITLVTFQTVKNLDDKDEFLINFDSYVSQHLSDDFKRKIEICESCKEQSNPNKNIKELYIYDFLFGNTETEYKFDNETQDTVETNLRRKNLEANGFENIFNYLEKISSNFVYLGAFLDETTYVSLSNTRIASIDYKEKVLVFDMDNTLFPTKFIKKELEKNGLSQTQDDIGKLREDFLYQKFRGKYRLPKSRCKDIVQRTFKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJG6</accession>
    <name>A0A4Q9LJG6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_2402p0010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002402">
        <property type="protein sequence ID" value="TBU07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2402p0010"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="566" mass="63499" checksum="FAB29DDDF022739E" modified="2019-07-31" version="1">MENRFKVLLLSSLTMFGFFYAYDIPAALNTHMKLGPNKVILLYSAYALPNMIVPLIFGWSSYIRSSNISIFLCLGICLGHFIFTVGLYLNIYGLMIVGRVVMGIGGESFTVIQNKVISQNFRGKEVSFSMSLFSCISRLGTVTNFIVTPYVALRIGSIFSSVIGLFLTLSGLSICMFLNKRQKVPIFKSLHPQNQEVANMRPFREEPEIYENINQNTNQNNNYNQEINEISNKKVPVGFYENENYQINLTSVDPSYSAWRHNNPSPQSLEFNGLPDFSENEQICARDTTNSNETPVTETQSEIIKNQSDFSTNNSLLTHLKYIPHDIANKTTINNIEHENKLYPATLRKMAEFNKPDPINQQRTSLEAKNSYHSTFSLLVVISFMFAVVWAPFYNIATMLFQKRYKVSGIVAGRFMAVIEGMGILNVLFVGGLADIYGIKLIFITIGSILLILGHTLIFLNKGSAYIPVIILGLSGPFIACYWPCITFLVSPDSLHTGFAIISCVLNIAYTFSPVMVSILISHDPSYDTVEFFILTVSSLAFICIVVLSILNRKMSIGLNKNICTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJV5</accession>
    <name>A0A4Q9LJV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2253p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002253">
        <property type="protein sequence ID" value="TBU08508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2253p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="26383" checksum="AC642587B2308BA8" modified="2019-07-31" version="1">MALDRKKAMIIASGLVISMLFIFAIICGLGYNKAGNVIKSFEADFKKVSATAQFKFITNDLNKTKLGDFASIKGKKVFELPFSSYDSAKSLIKALDHKKIEKVQVYTNINIDETIQIDASKFINIVGEIGFLVKIGFWFKGKTAIRSICAISSFIYKAIKDDLKEKEKVFVILNLEDEKNVKGFYVKTDIDGKIKTICSPKTFKFNDSKNGLEGKSHDFVAFIVEKVRKASNSIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMJ0</accession>
    <name>A0A4Q9LMJ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2143p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002143">
        <property type="protein sequence ID" value="TBU09504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2143p0020"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="16594" checksum="4103E487D1BE6C38" modified="2019-07-31" version="1">MIIIALLILITNIIYTRFYTDDFKKDITVEEFNNYIKTNKIVIVGSKTCPDFKRLKKVLSYINLQFKEIDLNSNLNMRQHISLTYNNKEFPVVFVCGEYIGDYHDFYKRYHLDTFFTDMLYKTLALRPVNFSRFNIVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNV5</accession>
    <name>A0A4Q9LNV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2041p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002041">
        <property type="protein sequence ID" value="TBU10079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2041p0010"/>
    <dbReference type="OrthoDB" id="2189043at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="247" mass="28838" checksum="304500D9D08472DE" modified="2019-07-31" version="1" fragment="single">MEKLLNDLLIPSKKIDAENELEKLIVTSNGQEELKTLLKENCTLVYVYIKNITSIWLTTNQQSKVVSVVLPLQDTLYCCVAIANDVNFNILCSYLEFLSKKEFLNKNFAFLLIEQLSIHPLKDIKFRRCLKALRAIFKKYEVLSRSDDLYSEIIRTVTLFKGAIFNLLIAKLSNDPDIVIPSLDIFYSLVFQDIHPFFEENSEKFFNTFFILFHSEIYQSRLCDIFKIFILKYADCINIETLLEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP30</accession>
    <name>A0A4Q9LP30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2027p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002027">
        <property type="protein sequence ID" value="TBU10094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2027p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12674" checksum="D1226EB0C2941732" modified="2019-07-31" version="1">MIIRDVIVTVTTNHTYKTANAHEFRGLYRSKCKRKQQKQFLSIDEEDLTLLGVIEITEMHEELQFMVLNNLQQKIFNPYYRKKAKLEETIYHKHKRSSKLEEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPH5</accession>
    <name>A0A4Q9LPH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1916p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001916">
        <property type="protein sequence ID" value="TBU10244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1916p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="28577" checksum="206EEBD6F23913BC" modified="2019-07-31" version="1">MFYILENILRWWYFDDKISISVVTQDEMKMNFTDLKYSVEFYRPNEKNEGHKYPVYGFVNKEEMYWFTTYDGKKISKEMLEKCVKDIDNHLEENIQLKMNKIKKIFLYFMVGICGIIFGRNLLNGFRSKGIVGIGTRFMEIFMYFMISGGFLNMLSGYYGVSSVFKYYQSSSYQFVDEKYVFICLMFFFSSFFEKCFEPKKHKIMYFVWLLGVMGLFRYVLYIINVKGGSYPFYFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ81</accession>
    <name>A0A4Q9LQ81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1657p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001657">
        <property type="protein sequence ID" value="TBU10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1657p0020"/>
    <dbReference type="OrthoDB" id="2196200at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="343" mass="41473" checksum="2D5996DDE76AC35F" modified="2019-07-31" version="1" fragment="single">SQTRIFSLFYFVDTKFISTLRIFDYKKIIFCKKANQNIYIFLNINNFLEIRIFSIKEQKIINSKLYNEKLHNPILNINDLEIFNQSIEVTDILHISARFLNTDLLISVTTKKYLFFIFKEFLIRKSNIKKAFKTDLKLLKYFYFGSKTLESSCLCGFLIFFIFYLDIEILQILDIFKCKYENIIYELINLSNINEEYFLQIIKIILKFSYKYENLITCIYRRCDKKENLLNLISFEYFKNIKSPESLRNIIVFFPDLLEKYIELCIFNEKEFLIPEIIDYLDKNGDIKGKNCIEKVFLKYNCLYLLKMCKQEIIEDLKEMNVILKIEEFNIQIQKYNNKKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ9</accession>
    <name>A0A4Q9LQJ9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1560p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001560">
        <property type="protein sequence ID" value="TBU10769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1560p0030"/>
    <dbReference type="OrthoDB" id="2193035at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="26812" checksum="FC29CCE5AD836CCB" modified="2019-07-31" version="1">MYWRNDKIGWEKIQDDIDISTHVLISHSSDYNRKSFETGNFVGERSKEGNKGSFLFTAPSHGYYMFSLNVKGLEEIYGDYNNNKVDNNNNVGNVDNNNNVDNNNDSNNNNLQNNNNKFAIRTRIYEGRQSDPRIVSQADTQIKEVEKQIALSVDYSKQISEEHKLSEEVDKLFSKNVSKIVWLVVLSVGFKILLMVMGVFFHVRLLVGVSSGKVLVVVSVKVVNSKVVVIVSVNSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL1</accession>
    <name>A0A4Q9LQL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1834p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001834">
        <property type="protein sequence ID" value="TBU10346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1834p0010"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="36739" checksum="539BAD657154D8A6" modified="2019-07-31" version="1">MVQKRKKSRRLTIRRREGLKRKVRDTKRKEIRKLRKLEKLKEKVPTSLLRTDEDILLLNQIKKNTEMRQNNPTVINLKLDWCDLLEKCDVFLQILDSRDPEGSRNYEIENEIIKNNKKMIFIFNKTDLITEEVKEEWISNYTSKGITCISDLDISFYINNNGFNESIFCIIGEKNVGKKKILSYLLSENISIENIHLYETEVKEKNILSSLRNPKAANIFEIKECLNYFIKNISVEKICQFFKTEKFENIEEFFEIIAKENNFYKRNGKLCHKKAMQFILGFFDTNKILFYSSFDINGSKLYNFKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQZ9</accession>
    <name>A0A4Q9LQZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1055p0010</name>
        <name evidence="2" type="ORF">CWI38_1443p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001443">
        <property type="protein sequence ID" value="TBU10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001055">
        <property type="protein sequence ID" value="TBU11747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1055p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1443p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13072" checksum="CB1EB2A762B5A860" modified="2019-07-31" version="1">MFLFCIFFLQIFTDNIEVDIRKYKKIKLNGKVIDLPKNIENGILRIHYPGYNKFKYFKNENNDLEIISDTNNILFKYEKSEILPLICFVVFIFSIGLIPYLLIIKRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA6</accession>
    <name>A0A4Q9LRA6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_1976p0010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="PITK01001976">
        <property type="protein sequence ID" value="TBU10161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1976p0010"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="206"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU10161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="416" mass="48933" checksum="DE8323746072C81A" modified="2019-07-31" version="1">MLDKTILIGFFISFNVEIILKARQLLKLITSEQTDMTKKIVTDEEFEKMKLYNSDKLYFSIFNEIIGYLRNIFVVKWSLLLGLYFYLESTFPGLKSVIQQVIYMIFVINISRILELPMDLFYTFYIEEKHGFNKSTLKIFFMDFLKSTIIIIVLLGFVVYGMLYIIDLFPKSFYLYLWTFLSVFQLIMVIAYPILIQPLFNKFQELPEGDLKSKIEKLAEEVGFKAKKILTVDGSKRSGHSNAYFVGITKEKRVVLYDTLLSQLNEDEIVAVLAHEFGHWHFSHTLKQILFGLFMQFFYIYAFNFVVKDTKFNEMVFKTTNVPMIVTLIYFSFISNFLGIVLTPLQNYFTRVMERQADVFAVKKGFGESLKNGLIKIHKENKSNLCPDNWYSVYYHSHPTLVERLCLIESEMKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB3</accession>
    <name>A0A4Q9LRB3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1403p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001403">
        <property type="protein sequence ID" value="TBU11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1403p0020"/>
    <dbReference type="OrthoDB" id="4691307at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020868564" description="non-specific serine/threonine protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="795" mass="92818" checksum="F2A43B10DBB86B34" modified="2019-07-31" version="1">MFLYIFVYIVIANCIKVLFRAKNQNESDASVFRFVNSLYGIFDENNSFVDISSDYTLDSNVMILDSLNPKANHYVLLEYMFFDMTKIESNLMTFLFYYKDNFKDYIYLGDIISMDNFIFLLYLLNLSFVYSFEYDSNTFFEILNAIEYLDLFGNSRKIIINNLIKYFLLADKSMEILFTENYISPQFIPNIYNIYNEILLEGINLFNGKCIFRNSSLFILHEKENIDYKSLLQTEGVHIFPCMLKLNVLNKFRMYFFSLIGFYMKMSDYAVLNLSEIDFLTENDTKIISCFSNVTEITLSSCFIKNSFIKIIPHSILCLSLDILKFSNILFDSKTFSEILNFRLKKISLDTCKITDGNFFTDLNLKESSKSLNSLILTGILLEQHDVEQISGLENLSELSINNSSICSTLFEYLCKNETSKLKTLRFFSNIYSFLDIKFVFNLTKLEEIDFSRNKFFYSPFKCNLSSEFKNLEQLKILRLCDVYEFNRKNICGIICLKNLKELIISKNNFIDKYFLNFQGTLKLEVFKCQNVRLLSMDLDFFSCHLDLHFLNLKDNDINSSNLHYISKFKNLYKLNLSMNKCISEDNFADFDLRRIQELKLNHCLINGSLSVWKINIDVLENLSLLSLSGNTLNISDILYIFNLKNLISLNISQCNIKKGYISSTENSQIQNLDLTGNILNENDLLALFKIKKFKTLNISRCNLTKNTFKLLNEISQDSNIEKLEILQNRLSKRDINFISNLKKLNKLNVSSCFLEKSSLSNLKNLSKYKNLETLDISSNNISTEDISSILRIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE4</accession>
    <name>A0A4Q9LRE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1945p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001945">
        <property type="protein sequence ID" value="TBU10201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1945p0020"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18450" checksum="37EADD84271ECE13" modified="2019-07-31" version="1">MAIVRKKNDRIFKEIKEMARDPPANCSAGPISDQELDKWNATIIGPEGTPYQDGIFELEITLTPNYPFTAPIVKFKTPIFHCNINEGHICLDILKNEWSPALTISKVLLSISSLLHDPNPNDPLNRKAADLYINARDEYNRNAREWVKKYATGARNDRTKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE8</accession>
    <name>A0A4Q9LRE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1398p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001398">
        <property type="protein sequence ID" value="TBU11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1398p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="39437" checksum="2F0B3192BDEC6A75" modified="2019-07-31" version="1" fragment="single">KITPVITTDSIPVTNTLCLTDTITDNITRTRTKTVIKTITDRERESSEIPTNEKKKYTKTIATTVSRSDMTPLIETVPQEKECLECKHVTITTYLDKRKKKRKTVVNTIYAKESVSSCNKKDKSICLDEKGKEIVTTIYVGTNKKFKIEHKDIKREYNDPKKSELKNMYNDIVECIRFFENEKNEELLEGGNFRFFITYNSRQKTPKKENGSYVQPYTDKNFEFSNKLIQFKQSECGNFIEDDNKILVQEIELKNKFNNKLSNKNYLVLQDLMVFSFLYKDNFKSNLKFGNVLLAAFLFEVIEIELDKIIWIFESKAQESSSFEFQINILYLRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH7</accession>
    <name>A0A4Q9LRH7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1429p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001429">
        <property type="protein sequence ID" value="TBU11014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1429p0010"/>
    <dbReference type="OrthoDB" id="2193092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="11">
        <location>
            <begin position="166"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="33466" checksum="115202F48C3D40FE" modified="2019-07-31" version="1" fragment="single">FLTNQKNLISNIKERTENEKFKEIVTFETLQTVLPRGKCDYIFYDNHFKIVGSTYEHKVFYSSVKGIFYLEKYDFDQNDNKEYFLALNVDPSIRQGQTRYSFIVINFYEVEEEEFTLNLTEEDKIKHKDLQAEYTGPVGSSFLKIMKILTNSKVFTTKDFVTKEGNRSLKCASKAYEGYLYPLSKSLLFLPKAIYMPHGDISLVEFSRVNLSVLTAKTFDMKIFTSEGQFTFNSIQKEDFGPIERYFSEHNINVRSEVIDDQDEYSEEEDEEDTTDIMNTSDGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ1</accession>
    <name>A0A4Q9LRJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory subunit of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1356p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001356">
        <property type="protein sequence ID" value="TBU11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1356p0020"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="30543" checksum="BE4E06D53ADF79AA" modified="2019-07-31" version="1">MIDNNITVHPLVMASVVDHYRRCDSKRVAGIVMGKIDERLFVTKSYAVPFSEDDKGNWFFDTSYSDKMYALLNKVDSSEKILGWYHSGPSLHKNDLDITKSFMRDLPNPLLVIVDVKAFNISEQVQIFRLVDDKSGKKNDKKFKYISCVVEGEEAEEVGVEHLLKDIRDCSVSKYFTNVKDIKSSMEMYEKSLTVIVEYLQKVKNNEIRVDQKILRYLQKCLNEVPIVSEDDDESKMALFTSLLANAVVKITDLVLSRKESVSEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL9</accession>
    <name>A0A4Q9LRL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small Ras GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_2294p0010</name>
        <name evidence="11" type="ORF">CWI38_1345p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002294">
        <property type="protein sequence ID" value="TBT97396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001345">
        <property type="protein sequence ID" value="TBU11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2294p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1345p0010"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT97396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="205" mass="23554" checksum="58A1C208C452CEBC" modified="2019-07-31" version="1">MTKKRITKKITIVGEGACGKTCILVKLTKGTFTTDYTPTVFQNSFAAYEIKKQVVELWLWDTAGQEDYNRIITLTYPDTDLLIICFSIDDRNSFEAVKNKWMPELKFHCRNVPYILVGTKSDLRRDSDRLEHMVSHGSIPVTTFQGMDLANEIGALKYFECSAKDGIGLDNIFRFAAEYLHNEHETKKGFSFKKFFEKLFCGICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP7</accession>
    <name>A0A4Q9LRP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0065p0130</name>
        <name evidence="1" type="ORF">CWI38_1318p0030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001318">
        <property type="protein sequence ID" value="TBU11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1318p0030"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="32232" checksum="745A0CDB157B0A3D" modified="2019-07-31" version="1">MNKNRWDLFEERIYKEKDIDNTNIDKDIINDAALPQFLLTKRKIKNKVNNYEHSKSLEVENCNFPYLVTRIRTLIELDELYGVEILKRGTLSPLKLQTETTDNLLCLEVTGKYLHNIDCAILKLKEIMKKGELALSFKSGEVRNVYNGYKNIISCKIEVGIYEIKNNFSIKEIVIFHLKRISEDLSKYRNKNTNFLEMIKFGEYTNEFVILDNLVIRLRGRYSGTIEICLDSESNDPCYLQVLATDLEYFKKGEYICKELIKKIKSEYFNIKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRU6</accession>
    <name>A0A4Q9LRU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1540p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001540">
        <property type="protein sequence ID" value="TBU10806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1540p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020798222" evidence="1">
        <location>
            <begin position="18"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="475" mass="56525" checksum="946ABE6792F99E72" modified="2019-07-31" version="1">MNLLFLSLILLFCLSKASNLANPLDIDTSGTRNAMNNCKESNKSKDIETEECLNVILSNIPFFTISFVLFWCFTAFTEYDLYYSTTKSILRYFRRWIINEAIDSKVFDGNENNILNEILMKDDIFEKYLEEVVQEKREILKWLENMQIFYYKEDYLEILRNSLHCIEFSRFIRTESLLIFKEIFILLFVINNSSISILSQECPPECNDFKVKENYFINILRRSYNRNKWKSLKIFQKREICERIDSNTLILITGLDVMCKIFSDKMDPNNLNKNTFSRICYLKGTVYPTLFRSNEIKMYLPHEYDQNFIEYLQKFLSKSESKIIFVTLFFSYTDFIVACFLKEILSKFGEKEFYDFFTSDAVKTNEYMKNKAFNDTIHEISTKTSIYEEITTYFIHLSQSMKTQLFLKVSIIKNEEINFLKIYDDILPSISSWNLRNNIRNDVFNSKMTTVFLYSLRCCIKQSIKRIMVPQCSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE8</accession>
    <name>A0A4Q9LSE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1178p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001178">
        <property type="protein sequence ID" value="TBU11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1178p0010"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="422" mass="47570" checksum="57BF0D4FD5FDB5E9" modified="2019-07-31" version="1" fragment="single">MNIGRKQISPTEFDNLWKTIEREFTKLTTHSLCNSVLVYNCVYDICTCVNNKYDEKLYWRIGDFLYSQARNHRTIIMQAIGNRHERVDKGVDRINNGIANGIANGINNGINNGIGSSTYTNTCTNTSNNNDIPYTTNPCSNPYTNTTTNTTNTTNNPNPNLTLNTRINNLSTNTPTYTTNPNTTNNNPYTTNSYTTNNNHYIPNTTNNNNHYIPTYTTNPPYTTNPYTTIPTYTTNPPYTTNPTYTTTINTPYIPHFHAHNILQSFSHQFSLFKRNTLSISQMCNFLNETLVSSKTARKIEDFAFLLWERCVIQHIDINFIVNLLISCIDTPTYIRNILLCFKSVIFDINNPLLYYKEVYEERVIKHITCKYSSVGDSKGGSMGGSMGEGVSRGEGYEGVSRGGSMSEGLEGVSNSSSNYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG3</accession>
    <name>A0A4Q9LSG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit of transport protein particle complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1745p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001745">
        <property type="protein sequence ID" value="TBU10460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1745p0020"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17323" checksum="0FE792CDBE3A9622" modified="2019-07-31" version="1">MCGYLQQILESKGDCEKKLEALGKDIGMKFLEIYEIRRLNKIVDILESITYTFLPKIYTSNRYVEKSKDFENVFLIIEDTPFFGKYISAPKRCEGFCADSITGGIISVVLTSFGYKNTVTACLSPSKNILTKVVYVIKINTEDLQREKRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ4</accession>
    <name>A0A4Q9LSQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1114p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001114">
        <property type="protein sequence ID" value="TBU11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1114p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="26019" checksum="E4F6E1FE120DCECD" modified="2019-07-31" version="1">MNLRMVLNISTSLCCRNIEIDSLDFNNYLVFEQSYLEINQEFFKTLEETQDKIYILLQIVSPTLSKILSDTNLVISKSLELIIKSEIVTYLSKYNYSEIYTDSVLILESIKSISRSKISEIQLLNKLFNGNEKRQKPITNIFRLIFRQPKYTINYQRVELLRSSSNLLLSICNHLAISEFLFSKNDFSKLLENFFLILQKYYLVKESLKELDSLPIICRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT10</accession>
    <name>A0A4Q9LT10_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1217p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001217">
        <property type="protein sequence ID" value="TBU11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT10"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1217p0010"/>
    <dbReference type="OrthoDB" id="2195518at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="18850" checksum="D097535ECE256A1E" modified="2019-07-31" version="1">MTLFKNLKVVGSHVMGGKEKKSMMQKYGGSSFLSVENTFIVNKCKDKKVVITQENKPIIFIYNNIYIPTLQHIKMEPDVLKKTIFLDEGAYKPLCSGAAVMAPGIYKYRHLITTEIFLNDIVKIDILNKGCIAVGIALMEINKIGAETKGQAIEVLHIEGDELDLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT13</accession>
    <name>A0A4Q9LT13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1591p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001591">
        <property type="protein sequence ID" value="TBU10715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1591p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="393" mass="47963" checksum="7D53F5F9B9447EB6" modified="2019-07-31" version="1" fragment="single">MYKMNTIDTENKRIRFSVGCALECSMYYLNIFMVSYIRFSVFAILFSKIHICRLNVKILEIDENKEFSSLQDYQDVHFLCMKTCTLLHSTQENCFKRYLTSYNSTNMFQFSYPNDIFLEFEFFNEKLIEKKEEVSIYIEKTDYRMFICFLKLLETNECTMKIEPVVFFEFLKYCNIFRVNRNNQYKIFIKSLVFHSIMFNEDYFARISAIFCLCHREYNNLHVRDVIECFFKFYLLSKKFIYELFHKYNPMVVSSRIRLYKKYKLVKNFISLQIEEFEFHFHNHLLNLKFYEIWKIMIRIFYIDKFYVDLVILSDDLNLDLVASSFPKNVKKASFLIYEDYLPLFDILNEINYFDSIQRLKLIFFCFTKHVVKILGFLKSLDKLTLILRKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT76</accession>
    <name>A0A4Q9LT76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1419p0010</name>
        <name evidence="6" type="ORF">CWI38_1082p0010</name>
        <name evidence="5" type="ORF">CWI38_1364p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001419">
        <property type="protein sequence ID" value="TBT99217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001364">
        <property type="protein sequence ID" value="TBU11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001082">
        <property type="protein sequence ID" value="TBU11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT76"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1419p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1082p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1364p0020"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="107" mass="11727" checksum="7B699233BDE59757" modified="2019-07-31" version="1">MARKKKIVEGIATKLPLAIKTGKYTLGYKSALLSLLNQTAKILVIASNFPSTKRRLLEYYAMLADNTPICIYDGNNNELAKTCDKGFRIGVVSVLDVGEADMLLAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU26</accession>
    <name>A0A4Q9LU26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1402p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001402">
        <property type="protein sequence ID" value="TBU11070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU26"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1402p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="383"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="896" mass="103870" checksum="B7A3AFD9B753BACB" modified="2019-07-31" version="1" fragment="single">MHSSTVTPRPDIAASGPNLCTIPISERLVVLRSILRSIEAERQEFIRCVFFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEKNGERRRIATCLAEPCSLTDTARFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDSTVLDLINRIVGEYADSHVPMTITDIARIIQTAQRPRSTWKESIESKISVLKLSKDILEKARRREELSSSQTKSLKKIMREFNLDLNKTNDLSEALVKKNELITVYEKKLTRYESRKQFRKENRMFELFRGRYYRGLSELNRDEIVSFWSTMWNKNNEIVTYDEYLIPFVPDTHQATFPSLDEFVDIINWLPNWKAAGIDGIYNFYIKKLTTLHMYLYDIVKAICFEGTLQANWFYHGLTYLIPKSCVTKVVQLEVERRGLLADNQLGAVRGVQGAKEQALLNVALNKEYGNNLKATWIDVKKAYDSIDHAYLTQVIENLNLPDWILKFIKVTISKWKIDISIDKGILLGDSLSPILFVLFMDPLSRKLNEEYAKVTIQTEDASHSTNHLLFIDDLKLLAKDGTTLEKMTEEVKMFVKNIGLEINREKSATNDSCCENTATLLEGIGVYKYLGIIEDSRGIPTRKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLINYHIGVLRLEPGDFSKLDDAVRAVLVKNKIHLCPGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENDNKTHLALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDFTRRHNEVVRCIHLPLLNKYKFKSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM2</accession>
    <name>A0A4Q9LUM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1270p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001270">
        <property type="protein sequence ID" value="TBU11315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1270p0020"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8579" checksum="A5DD5BC543A7EEE4" modified="2019-07-31" version="1" fragment="single">DKRRMNVGLTRAKHGLVIIGNPFTLSGCKHWEWLLKWFVDKRMVYEGAVSDLRRGVLFKKGVFDLRAVSESIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU9</accession>
    <name>A0A4Q9LUU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0755p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000755">
        <property type="protein sequence ID" value="TBU12439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0755p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="41441" checksum="4103561E29FA8E35" modified="2019-07-31" version="1" fragment="single">DKIECFYLKKCSLEVYIFSVNYFKFIDDVKTTYIRKIFLYDKLLSVLIDKLFIFSKIFRIFSVCFSDFNYTYFRFMIYDVKFSSEYVLNLPDKFLEFVTDTYAFSITASIFYTRIILSSKCYKNLNNLDNKTFYEEQIDYFNGIILKYQIEFYWRYEYALNHDQNSYSFKIRKNYSLKIVSLEISKSLKNDKINITTYISIQDRFFSYENIFFYDLAKTRYKTLILLNDYRDNSEYIYFECYFIGYDFRSKTAKYIFKSIFFEKKDKIILYVDENLKIVNILQYKDINNAYATINLENECIENIIANLFKWLIVKLFLPNLNFTQQIFINMLYENIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW8</accession>
    <name>A0A4Q9LUW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0611p0010</name>
        <name evidence="3" type="ORF">CWI38_1232p0010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001232">
        <property type="protein sequence ID" value="TBU11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000611">
        <property type="protein sequence ID" value="TBU12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0611p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1232p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445347" evidence="2">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="21040" checksum="291FE53CA381EF62" modified="2019-07-31" version="1">MKFAAIAKRIILILQLICFKCAIDELDSICCSPYDTNLIESSNAQREMISCTQALLFTSATSNEYSKSVCAVTLKGNPDESCEEIDDNLIDKIEHKDEISEKSDEMSSEADEYLENVPNKALVTNIKTQDSGSLLGKLPKRRIYKRHTASKIYPELEAYSAFLNPLASPENSEISGESDSSSGLSDILTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX4</accession>
    <name>A0A4Q9LUX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polar tube protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0745p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000745">
        <property type="protein sequence ID" value="TBU12469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LUX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0745p0020"/>
    <dbReference type="OrthoDB" id="2190813at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020386403" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1535" mass="157674" checksum="2E569F43B25AF0CE" modified="2019-07-31" version="1">MFLLFLILTSFIYTHPYAGGHLGSLDELGAPYGGMGGRHHGYSPFSGRGRRRRHESPEAAAGAAAGAAAAGNAGELAHMAYEGGHRGRAAAGALAGMEAGGGYGGAASGAAAGAAGGSMHGAGGAGMNNAAAAGAAAGAAEGAMRRGASPVGAALAAGEAEDAAGGYGGGAAGMGGAGYGGLAGGYGGGAGGNGAGAGGYGGGAGYGGGAGGYGMGRRLPSPEESARMNEAAAAAHENEAGAHRKAAAQDRGMAAGNLGGQSPQGGRGYGRDAAANQAAAAEHAGAADAHKRAAAYNQKRANELEAAEYARNAKAAADEGDQAGAANLMAAARLAKGGNHGAAANAAGMGGFGAGNAARANDMLGRAVAQQEMMNELGGGGAAEALGGGSMGAGGIGAGGLSSGGLGNAGLGAMGALGAHNPHMAADIAHAAAAKHNPAIAAGLGGVAGAAAARNANLAAGLSKAAALHDAEVASELDKAAQHHDNSIGNAAKGAMARAKAREILAAAPNGDVDKPISETPELKGMTYRQAAEEELENAERAEAHARNGDLAKMEEAAAAMGREAPRAGEAGLKAALEAKANGATDVEAAAAARAAAERENRRAGAKYNPQEEEDAEKALEAAKQARAAARAAGASDAETAVAGERAAARVAAEARARDAAKAARDAAEDAARTQEALDMAEAAEKGAAEGQAAALAKRAADHEQAALDAGATKEQAEAIGARVAAESAVPVANELLPVPFVEPPLVPVLTKEPIYIPDEEAIALEEAAREAGLAEAARASQEMADRDEIAARAAGAADRRMNELLADKERQKAAEIAAQINMANEGVPITPRPLIPPRPEEWDKEIESGIAADLTSNDIPPPLLDKNTELGIIGTVPDDTSSVDIRNGKMDFPLKTFNDPPANNEVEGAAKRKRNQLKDDLRNKITKKKFDSPLNVVEGEDGNLNIPESAEKIDIEDGRVYFDESAKPDMEKDNIDTSKLVHMINTGERKDIPIGRGYYVADASGTEMEVPSPRNADPVHMLVDKNGNKLDISRATGLDIAKGALKMEPWSKYSKRLRPTINTPVRVQRSADPEVNELRKKIAQLDNTTAEVITNPSGRSYVKLVPPYGVAEQVPLSDALVNITHVPEKVVKEAGQEGVGIIQGTDTLPLEEKEEEAKKSTSLNITEGKPGKESYEEVISKKGLEESVTDPTTSEIINVRNAFNHLPVESKEIIIASASRPLNDEDVDTIKNKQLVTQKVVSVGDTVIDGLKHKKQDLSKSLNIGEEEFESKVSGFDKNIINTFIKTYNTPDSYKNYLNLKEEISRVFGDNSSYIESMVLYLIGNTLGQTITVPAPTKKKVTVTETKYVMQPRQINKTVYMPVKVSEKRTVENHPGVKGLTSKITGKRTKDGPITKTVKQVGKGGGKGGVTYTSYTVPKGGVGNTYKVINGNTNPQSVKVSNKVNNVPVTRPATSTTPSVTTYQYAGGNGYPHSVTRVVTPYNVSTPTVKGSYKVPGKIRSIVNGTPKGVNNKDSNIEGVNNKDSNIGLLRGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ5</accession>
    <name>A0A4Q9LUZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1216p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001216">
        <property type="protein sequence ID" value="TBU11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1216p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="28602" checksum="918351C099B55F34" modified="2019-07-31" version="1" fragment="single">MHNCENIRNEKIKAVNNLENSVGEILMCDVDPNDPVCLVDTIPSSSGTDAIACRPANGMTNLNTDAILEGNRLMVLHSILNSVTVVEQEWPRSAFPSVQKRFDGMSRNGWLATLRYYNEKFGCTLDIDAFKKLAQSEMGMEVISDKNGERRRIATCLTEPCTLTDTTEYINLRDKFLRNWKSGGRTRKHPNELVDSKVLDLINRVVGEYAGVMYLKKPRSAWKESIESKISKLVLSKDLLEKARKQEKLSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV74</accession>
    <name>A0A4Q9LV74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0705p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000705">
        <property type="protein sequence ID" value="TBU12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0705p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020379170" evidence="1">
        <location>
            <begin position="16"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="422" mass="50416" checksum="4C0564E993E6C0FE" modified="2019-07-31" version="1">MKILWYFCITKYVLTSSYLETLSDDKMNVYTIHTFIDNYIKEMYNNVSESVLQSNDKNHLLVGYTETINSNEISRLSDFIVEREFKNMEINFLMVKNNEEVEKVFTIPFLILKREKCKKTKLTVLKFVETVDENEKDSYNYVSAGTFRNTKFIMKMLVFYLIILQKTVFKCSNPTENIGLIVYYGKSQDFLLNNFRNDYVANLVQNNVSASNLNLLVGNDSIFNIKKGNLQKFINFCHKNFDTNRFTSIKIFKLQKNEERTYSLENSMESGKLDLLVDSYELHFVPQISTKVVSYFIPYISFKIFTEKKGKIRNKIYKFESNLYKYTYEVENLSLRLKKEEENFNGSITRQDNNSSNIYILYFKYKSHSGKIFWADFDRKLFSGNKHTEEQNDKFFMFKNLLYEMIDLYFCCKKWYVFQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG2</accession>
    <name>A0A4Q9LVG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GRASP55/65 PDZ-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0784p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000784">
        <property type="protein sequence ID" value="TBU12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0784p0010"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="632"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="966" mass="112012" checksum="379089B6F6DF404A" modified="2019-07-31" version="1">MGATTSNLKSFQILKIQNNTAAHKHNLLPFFHFITEINNQPIKSPSDIKRLSENWKNNSLKLKIFDARTEEFFEIDLKHLDGHIGGICNNSNVCNNSGICNNNSDICSNSDIFKNNSDICNNSDICNNSSDICKEEVKNNNSIGMSVKMYEGEPSIFSLRIITTFPNSASSKAGLISEQDYIIGIENVQTKDDQEFYEYLFKNREKEVVLIVFNLGMQSVRRVILVPEREELLGCEIATGVFNLPPSSKMKLFFDFEMNTARKGINEEKLVEKMNGDNDEAKFVGEKADENKNENQNEEIEGEEMKGEKKNENMNEVKNEIKDEKKEELKDEIKTDIKDEIKDEKKDEKKDEMKTDIKDEIKADIKAEIKDEPSKTNIKDEKKDEMKTNIKDEIKYENICIEKNNSIDFFEETILENKNEISDKKNLKNGNVSKEDLIKEENNNKTQEIILDDKKRFENTDFKKNILNENKNDFADFKNEIKDKNITNYTITEEKEDGNKIEEISIDSETKKSEDLRVERENLHEDIISETKKSEDLRVERENLHEDLISDPQNEQSTSNYSLKNIAMGLFEKISSLSLNEDENVDWSSEKIGVESTECKDLSDKVTMENEEFKEIKATNEKQDLTDNFLGNENFNKKFENEELKNSNLKEEFISQKNLEIDCKNVQEKYKITDEERNRDIKKGEILDDENINANDISKVTDCTSSNIFHRPEEKSIDLNRLKIFFNEEVKSVDSNENKYEESKKSEILNENKMARNLENISMGKSRTDDGLDKYFSEGETTEESKEGFLLKDIEPLRMDGPNSSKSIFYVENNQIKNDFLKELSGFEETEKNNEEIFELEITEKNSENIKKNALLENTKKENTKDENKKDFIEKSSQVKLENIDDSYSHETTNISVQLDRPHSDEGYLSESDERMNTPSLSDPVTYDDSYNVKKENIVTEGDSIFQEEKNEFNVFSKNAIKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH2</accession>
    <name>A0A4Q9LVH2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1102p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001102">
        <property type="protein sequence ID" value="TBU11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1102p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="49098" checksum="8BB5FBA3A020A6C0" modified="2019-07-31" version="1">MRRKNEEVKEIVLKNIEKNKLQFNKISKINLNTDNAKILNVWEYSYNDFLIFINFMESFYLPVEKFFLRDFFQIISIFEYLEIELNWHLEKIISILIYKLFSVLECDRKELKKEAFEIKKEFNLPLQFSEIICKKIKRIVFSENFYDEDFLEYNLFPLLTKEYTIEYLDNNLFFYTHPDIETCLSVKNYRNSTLFFNIHFFFFEFFPLPNMLFFSHNTDYFLINASKNLFIDNIYEIIISSKINFNCSSNRNIQDGYFLPDNNTILDLSLPFLLKSLKNLEKVYPNGDHIYKILFLKNFIQFIATKTFKVVSIISKYSMKSCQNFDFDTDITENLCLGNNFPDGTIRNIFFKKRMIRLKTLSLYGFYIGKNDKKMLGNLENLISFDLINCFLLENSFSELFDEEKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI1</accession>
    <name>A0A4Q9LVI1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0821p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000821">
        <property type="protein sequence ID" value="TBU12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0821p0020"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="357" mass="41956" checksum="236ECEC8D21ED02D" modified="2019-07-31" version="1">MNHFYFIFLLYKIFTTTRNYSVGFIYEISQNRDFFVKKPINEYSKKYLLNEKCVYETLNHPYILGMRSSNFEMNEVSELQFEIYDFDLKVGIDCKCFNDFEKIAILRMLLDVVNYLHANKLVHNNLVLENILIKGKQLKLSNFAFSAFTDQTKERIYENLDTIGFYHNEIVFNSKPEISDDIRNLGCIIEELFQLSTYTYEEIEKSFTLKEARKLVNKMKNYDLSEMISVEMALKSKIFRFHYGFIRCFCGFPDKKIITHTGIYEKCGNSLSKIFLNKRIDIKCDCICSSSAENKTQKSNTILKQLMSGLSRGCRCCRAEPKNIVVTINGISNCLLDLIYDDLSIVEETYNKFFLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN2</accession>
    <name>A0A4Q9LVN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1070p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001070">
        <property type="protein sequence ID" value="TBU11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1070p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020943652" evidence="1">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="51727" checksum="BB1772B7697D7FF5" modified="2019-07-31" version="1">MAKFLKFLFLIFVTALCTKNPEKRKRYYVDTLIDIIKKEIHKNYIEKIQKYNKICSYEFLFLESNNYFNMESADEIYKFNFAKKPKESHILVGLVNKKEIDCGIVCRHSISLTNDDFFSFIFQDKYYQVRYKNIFPGNYSYHKTRDIREYFIKKHILRFIFWHLNIFKQTINKFISDRNSYSFVSIFSDMIFFENTDYDFISRLLLKQTYTREKNYYLLINDLKINDEYYESTTIKNILDYTFSNTIFDSIKNLSFERKDELNTIPNNNPNYNYHTKIVVKEVHICDCKRYYNLYEIYISSFQDEIIRNQETEAINIFGYSSVNVDIITFIKSNKSKKVQKSIPEISYIIIRDRQLNMEYHIAFTYKNHNYELVDISVNQNIPGFAEAILLKEKISCILGFVIKYRQYFFQLVRWKQTKSNSFEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVU5</accession>
    <name>A0A4Q9LVU5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0648p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000648">
        <property type="protein sequence ID" value="TBU12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0648p0030"/>
    <dbReference type="OrthoDB" id="2196332at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="41152" checksum="861CD08AFD76FC89" modified="2019-07-31" version="1">MDKKNEKTINIAKTTHSDSSLILIETPFKVNEEDIKENRKYISKFDINLLDENKIFDEIEINEIKKTVKNSESEKNFNFEIKQNEDSNILFHKTEGCCIDPLFYKYKFEIPNLLKKIVDSVVNKNFRYFYSENNILLLRNVLDNSILFSALVCEYERLFDLKDEHFSTKIIFILGREKYVKKLKTNQRLEYKKALEEHKTHDFFDKVKDLRKKTFMFQLKFHVNFIFIESNEDILREFKVMIKFLETPKVFIPKVKKHKADQKKEFFKYILTKIPGISITVGIALSDKFSSLKEFVIFLNSENSQSLINFMIPNENKTGHRKLGQKQYQIIYNTFLEDNGDFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX4</accession>
    <name>A0A4Q9LVX4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U3 small nucleolar RNA-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0598p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000598">
        <property type="protein sequence ID" value="TBU12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0598p0020"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="88627" checksum="ECFCB403BA3A5BEF" modified="2019-07-31" version="1">MNEYSHSFSIPCKSDSKGLYYNNNKMYFTSNNSIFILDTSTWEYSHLISLPKQLKNLVINKLIFTSTEDRIYMIGKRGNVIGTLKINSSIFNISPSSKYLAVGNNNVLEIWKIPSEYNFTLFQLERRIVGHYDRITSINYINSDCVLTTSLDCTVRIFDLKKGKSVIIRKFRDPQISAYFDIDTLIFVGSRGKITFLREVTTIKFILDILEGKNIFEEEIVECGSEGNFKNDVIMYGSEIEINKQTDAIKFKKVKREIFKNKFNEPEFVDFTVENYNLRNKENRKVGISETLCIGKDVLDSSYLNGSLYISGKTKEEYFLVQIDDEFLEKKLETEYFEIYKLENFVCLKGTSNLYFTGIKEFKLDFPDICSLDIYRNYVIVGSSDNKVRLYTNFKQFGQLEVNGCFGVHAAEKVIISVSLNGKVDALDYKLFKFRSFDLETKISKSAINEDGSILFLAEYETFNILVVDIKRSKIIETLSVHQGPITCMKFSNNFLFSLSLDNLLVQWNVFQGTYNSLEILGASNFCINNRMIAVSKHNEIQILDLQMNILKSIDFKENIEDISFSIDNSLILVRTNEFLRILHYKTHVCIQSIKLVIPDNTIPILLHYFDKKSFILALNDIKIYEIKSFEINPIELEIDTTFENLQKYLNDKNYFSSLSISLKMNNFELIQNILKTIPQKEVENIVKLLPRNLVIILRKNIKKIVKTDPFICLEWLKNCVVYHKGTCLEGSEVDILRVEIEKYLEDGYRNYYLDEFIKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY6</accession>
    <name>A0A4Q9LVY6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0597p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000597">
        <property type="protein sequence ID" value="TBU12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LVY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0597p0040"/>
    <dbReference type="OrthoDB" id="10692967at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2527" mass="285674" checksum="77A5F94DD6201DA6" modified="2019-07-31" version="1">MLNIDIQYLSTTLIQLQTETKKKHPKISEACTEALQLLSTNTSINTLLSSPILLNPFVLTVQLKQKIPLNILEVIYVILQTQCVNNSKGGVNNEDMLEGVNKEDMLEGVSDSKDMQEGVNHKEYKLEGVNNSSNEQQGVINTTNEQQGVSDTTYNYHPVNNTTSKYHPVNNTPNNNPPLINNTLYNNMDTTVNTILSSLSSNTYLTPPHNIKILQYTLIFLKYPLKIETLSLIFNTLLSITNNSNQQVSVTAKAITYQFISLIPETHPSFMYTLVTYICDILKTPKPFYYDILCTTLKVILNNTETNPKVDSTDISSNISNPTLTLNKCIKTNPNPTLTLDTRINNSTLTLDTPFNTINTNNTNTLDIISPISTLLINKLNNTLEEIELLKCLEAILIILNNNYTNNTTITSFLSTILNLYKHSEYKNAIIKFFLSFPFKYPFIYHILLTLYTEVFNSLDLSLYSTFNKDCLEYCCKIKDFLFIDNRSDRGYGVYSVVEGVSGIEGVSGYGGVSGYGGYRGSGLDGVSELEDISDRSSRLEGVSYKSSKQQGVNESTYEQQGVNNSTDNYHPVNESTHNYHPVNNSTDNYHPVNESTINYHPVNNNISLFILFFYKYMLEVKKPIHSNYQEQISLIFNTIIEYLIISNVNIDNKKSNKECNDNGKGDININTTLTLETCINTNPNPTLTLETCINTNPNPTLTLETCINTNNITNKNTNNNIITSTKNTNTNNIITNNINNTNTLINLISLYTSLSPLFLYNCISLCIKHKNNIHYTIWTIIITKITTEQETCWEYIVNSSDTFNTNEIYCLFKGICYTLINNKDIDINFKCINEDIYYSDSSSEIRGDNDSRKVEGDRDSREVGDDRDKSNVLKGDSIVEGKLGGDNDRDMLGGVNDSNMLGGVNDSNMLGGVNKLYDKQQGDNKLSNEQHPFIDLSNEQQGVNNNTNEQHPFIDLSNEQQGVNNNTNGQHPFNNNTIEQHPFINTLYNNEQHPFNTTPYNTNTHHPFINTLYNNTQHPFNTTLNLLRLKQLFLKNITLISNNIYLLELTLSVIYKLNSIDTLYVLVLEYYKTITYKEGSNSRLDSSDIKGRLDSSNIKGRLDSSDIKGRLDSSNIKGNTMDNTIKDTIKDNTIKDTMDNTCSVIPLYYIYKLCNKHINNTYSNIDSNSVSDIDNNNNSNGSGNSNTKGSGNSNTNGNNNTITNTTNNNPTNNTNPTITTNPTNTINPTNNNTLVKVLSLLSELIGISSYYFKDEWGVIFKILNITIKQRGFNDSNYDILRLIVDNIGFISDRGVKECIEIIRVLCYSGIVEGGVRGMLEGIKGDRGMDEGVKGDRGMLEGVKGERGMLEGLRDKDMLEGVKGDRGMDMLEGVNNSIYEQQGVNNSTYEQQGFNNSTYEQQGVNESTYEQQGVNDTTSNHHPANNTTNNLHPFNNTYNYLPINNTLLISNTSKNIVLNCLYLLDDISFHINNTDSSLFYCYFDCLIHFIRDKRCDVMDTAVKCVYNNLRGCYSKEMWIYINNRVLFSILEVSDIILKGVSIEDSNMGMFEGSKGGVNDLDMVGGVNNRGMLEGGVNIQGSKRGVSNHIDKQQGVNDTTNEQQGVSKTPFEQHPVNNTTVIRRVNSLLFIINETNTFITSTPYSYITPFIHKYIYFIQRGLTSLYNLHNKDEIAGVLIKGLECILKTVNSKEGVRDIDMVGGVTYKDSKEGVTYKYNKEGVTYEDIKEGVNNSTIKQQGVSNSTYKQHPFKNTSYKQQGVNNTSYKQHPFKNTSYKQHPLNNTPYTHHPFNNIPSNIFNDNLYTLTCSIINIIGNISNDYNEEVYINIIGVIYNIPLYVIIPVSDKLLNNISNILFLDIEDDSNRGVNNREYDIKGVNNRGYDIMGVNKVSDIQQGVNYSDKYYKGVNNSTNEQRGVNATIDEQQGVNTSAHEQHPVNKTPYEQHPFNTNTTDEQHPVNTNTNTDEQHPFNNTIYTHQGITPLQLCILRYLEYLGINNNIFNNNRVLNYCKWLDMCNYSMCCYLMNEISRIITSNGYNRSIKDSTDKSITDHVLNTNCIVSNMNSKTTVDIKSNPTLTLDNCINNSSLTLDTSVNNTTLTLDTCINNSSLTLDTCINNSSLTLDTCINNSSLTLDTCINNSSLTLDTCINNSSLTLDTCINNSSLTLDTCINNSSLTLDTCINNNPSYVISTVIKSITSLMFTKNIHWERGMICLKRISNCITVNEYKDYLDCCYKIFIEDKVKGEVSFERKRERILIEYIGVLEGVIYRILDCYKEKEVRGVNDIRCDVKGVNKGSNKQQGVNISTNEQQGVNISTNEQQGVNIITDEQQGVNIITDEQQGVNITTNTYHPLDISQDEQHPLDISSNIYHPLNTNTTQHPFNNNNTIYHPLNYNYNLHDDVKRTFLLLDSICEGEVLFRDKLSLRVIGVLFNHTEILEVREMVCRRVSRVLRRYVKCVVNQSMSYKVRDMCVRVLECMESVKDKSVIECVKKEVLDCLVGMEWRVVDCVRRVLSIMFSDIMFSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD1</accession>
    <name>A0A4Q9LWD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0550p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000550">
        <property type="protein sequence ID" value="TBU13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0550p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="21487" checksum="49E7C09CC9FFDB87" modified="2019-07-31" version="1">MSSVQNKLEFLEVLNHTKSDLQGVYIYPLSKKIFRCYIFIRTGIFHGNGYCFTITKSNTEWILGGSSVIEQIKEYIKDGDVGESSKDGSSVNGGHITYSDNILISTFTTSNTPPTINANNPSVLYFPTSLTLYTLLLKIRSILYVTTPLSPIITSIPSENFRKAILSKLNSFIENKSKSCLKYYVRNEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI9</accession>
    <name>A0A4Q9LWI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0853p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000853">
        <property type="protein sequence ID" value="TBU12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0853p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19682" checksum="121253E8B2627C37" modified="2019-07-31" version="1" fragment="single">DSLQIVETEKLRKYDLLANELDLIYKCSVEIIPYVMTWDGIVTKYHKSHLESLEIPMNVEAYIQSIVIKKTVEMISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPTHPLNEEKREEDGAKNFKPKNKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP1</accession>
    <name>A0A4Q9LWP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0884p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000884">
        <property type="protein sequence ID" value="TBU12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0884p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="288" mass="34279" checksum="5742DFD9F49669A2" modified="2019-07-31" version="1">MKSNQQEIVKIFDDFAKNQRISQLIFSFFCLYWDCFLSPVNEIYSIEPSRVLELSKRQNRTSEKYNNDEFFKNLELIYKNNERKYSPFFFSNTVSLDAHHEFENTIFSDIRPVKSDSESIVDLNNCHEINFSIILESEYLIAVFICDFIQNIIDESEFSTMFSSENFSKNEQLALKEIYEKIESIDELKPFKSEISGSLTHYLNIFKKDAHLVFAFRKLDERLFSFIEEESLNSVVSVFTKQHIRDKLFGNQKIYKVLFDLYKKYLKRSAENSKKIKCVKSINYMDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX37</accession>
    <name>A0A4Q9LX37_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0465p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000465">
        <property type="protein sequence ID" value="TBU13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0465p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27999" checksum="5FD2A8E4BEBE03DF" modified="2019-07-31" version="1" fragment="single">WLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKNKNKITLIEVGITSQDSLQILGLIYKCGVEIFPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTRAYMGVIMGAEMHEEPTFTLKQASTKEYGSDLEEETVVVKELKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX95</accession>
    <name>A0A4Q9LX95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0441p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000441">
        <property type="protein sequence ID" value="TBU13403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0441p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="31606" checksum="90E794A82BEC75BE" modified="2019-07-31" version="1" fragment="single">MRNIEKYQKKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTIKHPPPSQTCSKMFHSGLDTLSSPNATVTSLPRTLAIPESNRLMALQAIFDFVTVEPKEWPQIIFFAVQIRFETMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENEERSRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATSKEKPRFAWKKNIESKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB1</accession>
    <name>A0A4Q9LXB1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0781p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000781">
        <property type="protein sequence ID" value="TBU12375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0781p0020"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="190"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="47784" checksum="8823399189A9AA61" modified="2019-07-31" version="1">MYNIPLNSFSSSSKQKQSDRYTPPSLTICTTQLSSSTRTSRLNTRYIDTTPYKILDAPGVTDNFYTNILDWHNNTVIVALSDTVYTYNTDTKKVKEMVCVDTDSYVSSVKGCNGTVCVGSSDGNLYFIDISTNKIIHTLSVGSSSNIGSGNSIGSGSGTGSSSNIGNIGNSCIGSSISNSSNIGNFNRDSKNQLISNNCNRRVRIGTMDWFDNNTLTCGTKDGNIYNTDLRCKKIINNVQHGDEVCGLKWSTDKRYLASGGNDNIINVWVSGSCRVRDRLVGHNGAVKAMDWCPWKSGMLVSGGGNNDRSIRYWDVNSGGCLGVTQCQSQVSGLIFSPKYREIISAHGFSDNELVVWKVSKMKKVSVFGKHDGRVLGCAVSPDGTCLASVVLENYGHEKVYVLDDKGEVGLRGVNSIVQCLKGVKINVVCLMGVNDKYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE7</accession>
    <name>A0A4Q9LXE7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_2438p0010</name>
        <name evidence="6" type="ORF">CWI38_0197p0030</name>
        <name evidence="5" type="ORF">CWI38_0429p0030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002438">
        <property type="protein sequence ID" value="TBT97192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000429">
        <property type="protein sequence ID" value="TBU13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000197">
        <property type="protein sequence ID" value="TBU19810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2438p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0197p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0429p0030"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT97192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="242" mass="28983" checksum="27C026F38610BB6B" modified="2019-07-31" version="1">MGNILSRKTSIRKILFTMEEKIKNTETYLKGLKQKKETSRKNFYYLTIYIGIPFIAYIYISNKNLFLNLFIFLLSFFVLRFILFQFFDRKINYNEKLLGTLKETQKKRIEELKKESLYLETKELVEKYDVKEKEKRNTSQQNLQNITPVKNICKTKRGIVDKFADFIIGEDPSSMYALICEKCFSHNGLSHPLEYNLMKFRCFNCEHLNDKTVVLKNEPRKEEENKGKNKEKDKEKDKENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXP7</accession>
    <name>A0A4Q9LXP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0729p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000729">
        <property type="protein sequence ID" value="TBU12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0729p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12581" checksum="79BE6E96865F0DC8" modified="2019-07-31" version="1">MVIHLAGSEKVFDIPENGNYIATFPESGSYSQLFNIRYIPAHKFKIMSYGMCLEYDLKCDCVMRKECSNKNLQYYEVEPTEIFGFELPDKFKGRPIIYYSSLSYLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR2</accession>
    <name>A0A4Q9LXR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0420p0020</name>
        <name evidence="2" type="ORF">CWI38_0525p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000420">
        <property type="protein sequence ID" value="TBU02757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000525">
        <property type="protein sequence ID" value="TBU13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0420p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0525p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="830" mass="96744" checksum="6B2A84CD68F5D323" modified="2019-07-31" version="1">MNILYTEIFYSLSIICSKRYRNGSKKDSTEIAFSSRSDIIEKHDEEKTFEKPLVKCLSHSETFGAAVADTSLLGICDDRANKKTKEDAISDSVEVSSQINVHSFTATNKDKRNRQLFTRKKNKNSLQSSGNTAKIINQKPTYVPKTFRLLKIFESRKSEDSSILSISESSENSTQLFHKNKSSSKYMPDSHPLRGDNLKYIIADKNTLADPNLNILKTNLSPNSYKTESSCSKISNKLQFGLEFKGTNKRMRLDISQELPPNANNYNISENRSCLCSNKPKKQKQTETSCGKNTIANKISHLCKKNVNERSNNTLPIYLSSKIINKKLLKEIIPKKFAKKIRKKSSNSKNITLKCLDKKCFEPNKRPIMHSDDLGNQKYNISALDPLKYDEYIEYISNLSLAEIQKIVALLKKNIHINPRKIKNSVENKKPILYYSNKIRNECEEIVTDISEEKIPRLNRQIDDIIYKTTNIDSFVDLLLNEMNKLGSLDLKDANSLNILFTTFQEIMGYEKNIYKKIQVDEILRHINFLDINHSLELIVKNSRYMMLPETFYILSLYDKDIKDFIKEQNLVHVSFLLRIFALHIIKILPNRKVQFKRKYIKKENLYRSQYFYKIFNLRKIMYNIFLGIKEFNSKANLYQLLNIFDFKQKIIYRNHIFEEYLLFRLQLNSMFILILCPEFKVQNNIFIRKVIAILGITCFSRSPDLKRLNSKLHRICNDRKNIPKILKSLCHTFLQKDMSFLNAPSSSSHSDTSDLEYKEILDFYSKTNGFISEPSKAEEDIFKFLFKLEFEIFKFLDIEKFGTEGFNGLEELLAKKYHDSNPCNSGFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY86</accession>
    <name>A0A4Q9LY86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0330p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000330">
        <property type="protein sequence ID" value="TBU14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0330p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="778" mass="93605" checksum="B5E9779F5FC7299B" modified="2019-07-31" version="1">MREGNQIVTNRNLNLNSLLFVLLITLKVIFPQKTIAIHFYGSVETKIQRDSLNNYIYSEVLSQSTLEKRDISLFDIKNKISQIFIIDINIFPLKFLNEDEIPENQQYNIYINNNLLNYDDFVYFYNIVMSFPYLIENINECKYLKIFRIIDIFKFKNDKLFIDFIRYMLASVVFNLVDLEKWNVFSKTKNVYLVNDAISKKVILEFFRLYFIDNRTSNKIRDISRILESIKLYKFVIINTKEDFLYIYNDILQEILKIHKNIKSFQKIFNTIFKIHIFKRLLLFKINYNCKYNCLLDLCLFKNCDEIFLLECLNTEILIQKIYEFRKFIRLKTLSIIDSKFTIKDEISWFETLNVEKFYYVVSKYNSVTKSSKFGPESPLCNIFYKFKEQIYNKENESNIYYRDSDCPCYDQNTRIDLKCHQEKSKIERLINIKFPFQEFFYMEVTNSFIKFSFYLMNYKEFQNITIEFSDTNLKDFNLKKSEILNNREIFTNIEILTNIVTMRIIDSIVNDIFLSKVLLFPSLKRLCISKSEIIFSKKKVEFDRNSKIESFFCYESRVNNKKCVFDFIYKLDALKEFEISCYTQITNIFEPKFYDENLIMINVTNLKYSVKYYNNDYTPFYSIFPNLLHFNFSFECSEGTLYNIFFKKNFVYLRSLTFNDITVGIKDANALKDLRNLTLLYFNENCKFTEISFCNLFDSNNSYLLEELRFPNMEYTYCDLQFLMRLKFLKKIYVHGFINKNNIIFLLKVFSSGVKITIKNVFQFKNQIVEGFGLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB7</accession>
    <name>A0A4Q9LYB7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0475p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000475">
        <property type="protein sequence ID" value="TBU13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0475p0030"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020651970" description="Trehalase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="509" mass="60559" checksum="CB81B2DC4C4E9BAA" modified="2019-07-31" version="1" fragment="single">MRFYCFNSLFLFFNRHILAAKEEMEVSQMQNVVDKSENPMLSRVHEKLLSDKSSKPEDNESFLYQATEDISGSLERKKDFEYGICLSKSDSIDEMEKYTHLELFIALNVLEVEDIKTLSDLVYKFDTKKNFLHFKENLKIVSKAISSFKTLKEYVLYILSLYMPYKEQIETFYRKNFYLPENNLENVNLNFNRSLDRFENLKNKDLKRVASHLLERWKFLCKKHVRPFDVAGREKTYSTLVLLPNNFVVPGGRFLEFYYWDSYWILRGLITSRLMVQAFEVVKNFIWLINYFGFVPNGTRKYYNRSQPPFFVLMLLELHKTGDKSARKLIVEEGIPAAIKEMQFWRENRKVEIKINGHVFTLNRYCVETDYARPESFMKDIRDFEKMQTDDKKVENKFYTDIKSAAESGWDFSTRWFSNNASLQSICTSDIIPVDLNTLLFASEKNLDFLIKEHNFLNQSGIDFGDLSKKREEAINSVLWNPFEKSWNDYNFKKNTFTQDVFYFSNLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG6</accession>
    <name>A0A4Q9LYG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0859p0030</name>
        <name evidence="2" type="ORF">CWI38_0638p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000859">
        <property type="protein sequence ID" value="TBU00922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000638">
        <property type="protein sequence ID" value="TBU12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0859p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0638p0050"/>
    <dbReference type="OrthoDB" id="2191220at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="125" mass="14830" checksum="58E4904005BF3D4D" modified="2019-07-31" version="1">MKKDVKENRTVEDNKTKRYNQTEVYKTFLSSNNGISFIIDKAKEVSRKNKESNGRYEGLGLNGEKIRSKEELYKSVENIVDFYLTWVSLCPGRKFLKMNKYDFLCEIENFCSKSEIKKFFSYLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG7</accession>
    <name>A0A4Q9LYG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0434p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000434">
        <property type="protein sequence ID" value="TBU13426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0434p0020"/>
    <dbReference type="OrthoDB" id="2187276at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21306" checksum="CF8E78E752A3E657" modified="2019-07-31" version="1">MDKRTLGGYKKYVFEPKIPTDNEEFSFSSEKNEIEPDLNSKATKTGEISKKEKKTKNVVKIKNPGIIAHSESKKSTNFDQNVIFEDLNVLEEINFSKENEPKLISQNEKAQDINLLDDVLFIFNFGHGFTPKSILLYDDGSICAKNDTEIKKMVKRNVENYLAVEKEEDFVEVGQIAGIFTACKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR3</accession>
    <name>A0A4Q9LYR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0597p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000597">
        <property type="protein sequence ID" value="TBU12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0597p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="611" mass="69964" checksum="1DE58097F71D6106" modified="2019-07-31" version="1" fragment="single">MGRKKNVNSKISKITKIKASNDADGVKKSDIGIQKCKLHPPAISLPPSSYTTITPPPPSQTCSNMQNSGLDTLPSPNTPLSLRLKSLRASDPISESNRLMVLRTIFDSVTADPKEWPRIVFFLQMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRGIATCLADTCTLTDTTKYINLKDKFLSKIKEISEKEIGKVVVRTRKHPNKLVDSKFLDLINREVYEYVGAHVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLYKDLLEKARKQKKLSTSETKSLKKIMREFNLNLSSNESLNVYEKKISMHESRKQFRKENRRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDIVTYNDYLIPFVSEDHPTTFPLLDELLNIINWLPNWKAAGIDGIYNFFIKKLTTFHKYLNDISFKWKSEGRGLLAENQLGAVRDVQGAKEQALLNIALNKDYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSFRKLNEKDTKVTVQTDAESHSTNYLLFIDDLKLLAKDSSTLSAKTGETKEFLEVIGSEINKKKSATNDTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU1</accession>
    <name>A0A4Q9LYU1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0590p0040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000590">
        <property type="protein sequence ID" value="TBU12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0590p0040"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="169"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="55388" checksum="3F4C15FF50540E60" modified="2019-07-31" version="1">MEQKMDALSIRPCQNINQLFFDIKNPIVRLRGFVYNIRVRGKRSFLVLRQGIETVQCIYSKGDGCDDTLDSESYKNINQTPLESFVEVFGKVQITEIKIESCSTKNMEILLLGFKIISKCDTALPFTVKDASQPISGKGYDPSTPKVMYKKCLDSRCLDLRTLHSQSIFRVIDSVMFYFRSFLRKKEFLEIKTSKLIESASEGGANLFEVNFFKKKAFLAQSPQLYKQMAIIGGMKRVYEIGHVYRAEESNINRYLSEFIGMDIEMEINNTYMEIVELIYEMFIFIFDEINKECSAEIENIRKYYHFENLRYKKQPLIFSFKECVAMLREENVQIQDLEDFSRENEKRLGNIIAEKYNVDFFVVKEYPYCARPFYTHQSSEDPLYSKSYDFIMRGEEILSGAQRISDYTQLKENAERCKVDISTISGYLDSFRFGAPMHGGCGIGMERVLKSFFNFNDIRYFNMFPRDPGRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ57</accession>
    <name>A0A4Q9LZ57_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0236p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11340" checksum="BB9C1A6B28E47117" modified="2019-07-31" version="1">MIGIIKGIESYRGVRMIRRIKGIESYRGVRMIRRIKGIEVRVLVITEEMIRRIKGIEVRVLVITEEMIRRIKGIEVRVLVIREVDRDKRVLISTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ94</accession>
    <name>A0A4Q9LZ94_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0233p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000233">
        <property type="protein sequence ID" value="TBU18638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0233p0030"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25550" checksum="8EB1040EE8C4476E" modified="2019-07-31" version="1">MINWGIRSHSVQEILDNEVITDVKIRNNRPNIFILDKKKNKITLIEVGITSQDSLQIVETEKLTKYDLLANELGLIYRFSVEIIPYVMTWDGIVTKYHKSHLKRLEIPLNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPKPPLKEEKGEEDGVRILKPKNTIPLISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA0</accession>
    <name>A0A4Q9LZA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sec61-like protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0535p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000535">
        <property type="protein sequence ID" value="TBU13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0535p0010"/>
    <dbReference type="OrthoDB" id="2194864at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="99" mass="11132" checksum="0653286BB0C172C3" modified="2019-07-31" version="1">MSDTKKKTNKSSDIFFYATSSRKFLRKCVKPSFKEYVRLFYVHLIGLGFLGAIGYGVRLIHIPINNIIVNTGKIRLIKGGVIIVRRGKGVISILSCNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB8</accession>
    <name>A0A4Q9LZB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0226p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000226">
        <property type="protein sequence ID" value="TBU18874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0226p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="455" mass="54164" checksum="FCE14E2ABBC43BCD" modified="2019-07-31" version="1">MLVCYLSAKRTNDIFFKKYVAFKSETRNVELIKIIDLTDEISLDLYPISNKDFIGPYSFIRNAEKLQSDILGEMIAFTMNIDFDVVKMIENIVIFGFPDIFSFKKVTNLYEKYKPNIFAKIGFYLMRRNIEIGFLYKFYSTLKNIRIQDDQVCNVLFRKKHFLSVEFRISKIEQKDLPRSETPVESKIDFDLREWRNFILFLLISEFSTDFSITDEEFVDRVSLTCRKDNVEQFSKRIDSIITYLGFCFPGITETLQFIQNKKKENEEQNKKDNYKNTYYILTNQTNTYLNHLINDVIIANRFKIEQFFQNIDIGIKLIIDNIIRSFEFPQRDAIAKILLPIGNISFITDTRANNMITFVKICLEFICQVYKCEGIDLDTRLKIISDFLIKRIQEEISKDNDIFLEFISFINSHRNLISNETFNHLFLGLIIDLRVYKNFTKILKWKYTKHFEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ7</accession>
    <name>A0A4Q9LZJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2453p0010</name>
        <name evidence="3" type="ORF">CWI38_0349p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002453">
        <property type="protein sequence ID" value="TBT97172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2453p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15575" checksum="5746BC3BE50083B0" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKILEIPMNVEAYIRSIVLKKTVETISFDRRTGLESGLNAEESWERASMGVIMRSEMHEKPTPPLKGEKREEDGVKFLKPKNYKPLISQEGTTLKEPTNNINEESDLEEETIVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL3</accession>
    <name>A0A4Q9LZL3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0215p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000215">
        <property type="protein sequence ID" value="TBU19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0215p0040"/>
    <dbReference type="OrthoDB" id="2195025at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="217"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="722" mass="85210" checksum="1568F96904A3A5ED" modified="2019-07-31" version="1">MTPAPIPMTDLKYSRALKNENIKNGQKWYAVNKEMLKGEKGKSKFVKNSYLVDQNGRINPKYKKGVDYDFVSAEDWEIFKKNGFEVEIERKVIETEKGFVLEENPVLVTFYFEKADLNVFENCNEDVEVSDRFVRKCTLVSSEDFIFSVVETLFLDKMPLQEFKEKYEVRKPNSEKICPEQKFKYLNSDEIKLIISSKRKNLNTSLIFLKQKGSGLCGLFNLGNTCFMNSGIQCLNVYEEFIHYFIEESYKMHINKENPLGSKGRLAIAFSDLLREMWLENKTVVMPGAFKRVLGNETGKFVDFQEQDATELLDYILNFLHEDLCYGTNSKKEIIEENPKEYWKKYLEVNRSIITELFYGQVLSSLECMECGEVGKKYEPFMYLTVPIPEKKKFHFGVFLSFDSDNRIPIKILAEIDWTVEELKKAIKLRYATKLDILCVSVKNNKIVEILKESTKLSSIKTNIYCYEIDKEWSPENYIWLNIKILAYIFLNYNFNFIFLLKLENNTVEHIYEKIVSKIEPFINSSNIVFGYEKWKDKFEVKFSKKEKNINNFGFVTAFFKDSEFTDLFGKNFNIEKNLVNETEKNLNIYDCIELFTKKEILKGVEAVFCEKCNKSTNRSKKLDIVYLPKYFIVHLKRFCYYKGYEEKIGIFIDFPLEDLRIGNYKYNCRAICNHYELGAGAGHYTAYIKREEWYCMNDSIVMKINDVKKENAYILFYEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN8</accession>
    <name>A0A4Q9LZN8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0497p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000497">
        <property type="protein sequence ID" value="TBU13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0497p0020"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="61"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="40182" checksum="FC00C045D0D21269" modified="2019-07-31" version="1">MQKNGNLHIMKSKKVLFSLLITLIIVQIFVLIVLFKKQRKINNEKNQLNSKITSSSGKIIVGLKNENLVCYFNALLQAFYFQNNFLEKLFSYKHTQDQKCISILKEVFNKMSKGIIVNTSKYLKQILDLDAQNKSFKFGHFEDAGTCFNIFFLRILKELNNGREVICSEITDIEQFKTNCFIGELYFYQLKRTYYCSICNETNIEFQNNQTVCLYLNNSVQESINIMFNTECFECYQSNPEEGVHFATNIFEITSLGSNIIIKNTHFPMKNANVLINNKITIHNQEYIFKACVFHIIGLHYYTVASLESVLYKLDDLSVSKLNIKSIEDFGFKHLPDILIYEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP8</accession>
    <name>A0A4Q9LZP8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0333p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000333">
        <property type="protein sequence ID" value="TBU13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0333p0020"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="17926" checksum="DFC66E286EF66725" modified="2019-07-31" version="1">MQCICNLFIEKIDYKGQELAKKIMMIVYILGYTMSLIAGYTLGDLKYVLYGGIATVILVVLLVVPSWPFYLKEIFENEIKTDVNICKNRPKITFIKAGIKSQDSLQIVETEKPRRYDLLANELDLIYKSLMCIVERAEMHEEPYPLKKLVPRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS8</accession>
    <name>A0A4Q9LZS8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0188p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000188">
        <property type="protein sequence ID" value="TBU19840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0188p0010"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="10">
        <location>
            <begin position="564"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="777" mass="86502" checksum="92B60F6488E7371F" modified="2019-07-31" version="1" fragment="single">MENQDNFSSAFSYEEASQDIISINYTPSQTEPSSSLYSQPLIETERVKVIWGTNINVQEVSDTFKEFIRTFTDTSSSCRDNKCNIGDGDSNNNNNCNNNNIDNNCNNGNNCNIENNNNIDNTNTNNHPNPNTNTNTHLNNYTYLDQLHSISLTHHNIFYLNCTHIKHLPLHTQLLTYPQEIIPILQHSLQELLYEISPNTCISIILSPYNIGKLLNIRNINPKDIDKIVEVRGMVIRISNVIPEMYKCVFECVVCQRVVVSDSEGSISVVGNNNIFSTSVIDSTRVIDSTSVVGNISNNISNTNISNISNNIYTNNNTNISNTNTNNNTNIYNNIPNNNISSGKNIAHPTDCVCGSRFSYKLLHNKSMFSDKQIVKIQEHPYNIPHASTPLTVTLILTNNLVDSLLPGDKVIVCGILRGTAVRQVNGFKMNSVFRCYVEVLNSGVKGVGMLGGDSKECDNNMDSRECDNKGDSNMDSRECDNKGDSRECDSNIYTNNNMDSNNNNMDSNNNNMDSDISSNPVYTNNPVYTNNNISNNHTNIYTNNNNNISNNHTNIYTNTPPFTYSTLYNSIAPSVYGLENVKKALLLQLFGGVTKECLNTRFRGDINILLAGDPGVSKSQILSFIHRISPRGMYTSGRGSSAVGLTACVSRDIDTKQFILEPGALVLSDLGLCCIDEFDKMNESVRSVLHEVMEQQTVSIAKAGIITTLNSRCSILASCNPVDSKYNCKKSIVENIHLPCTLLSRFDVICVIVDKYEEENDRRVSKHILEMYSDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX5</accession>
    <name>A0A4Q9LZX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0310p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000310">
        <property type="protein sequence ID" value="TBU15615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0310p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15349" checksum="FC13BE93EB465AD8" modified="2019-07-31" version="1">MSDETIKSIKKNSIVKFQNEKILIELDSASENCRKENTSDPWRKLTLCMCIFLCILNFVWCISNWGENNLWIESSTIIGFSLSLYCIFELVFGDITDRLRVILILIFAALVIFLYIITILTTLLILKNDSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M037</accession>
    <name>A0A4Q9M037_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0091p0020</name>
        <name evidence="1" type="ORF">CWI38_0261p0060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M037"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10650" checksum="B03170CD2442F9E3" modified="2019-07-31" version="1">MHLARIKNFLRIKYGLEEELYNARKNELECVNDSSRCNILLYLDRNVFWGAEGVCQHCNASRETVDYLATRCKKMLDHDNTRRHNKECDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M3</accession>
    <name>A0A4Q9M0M3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0116p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000116">
        <property type="protein sequence ID" value="TBU20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0116p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="22881" checksum="FE63A11D4D113A29" modified="2019-07-31" version="1">MKVTFFSLHLHILNRYKFKSSKRIRSHSSGFQDKNRVGISLKDSFQIPETEKLRKYDLLVNDVKIISYVMTRNGIMTKYHKSHLKRHQTLHNVETYIQSIVHKKTVEIISFDRRRGLELEPNAKRAVKVRQWVSQHFTLKEANNKKDSVLQLTSNNITPFISEGEATFEVPTINISEESDFKEEPVVLKKVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Y5</accession>
    <name>A0A4Q9M0Y5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0089p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000089">
        <property type="protein sequence ID" value="TBU20324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Y5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Y5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0089p0040"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19866" checksum="45FCCBC9963EA854" modified="2019-07-31" version="1">MEKEQEEIINWINTLLTETNSPSSLQDFLKDGIILCKLANKISPGTCKYTESRMKFKQMENINAFLDSARKLGVPEYELFLTVDLIESKNIKQVVNCLYSLSRNVQKSGIFDGPFIGPKLYEKRNIEFSQEALDRGNVSVYKQMGSYVDFSKYTLTDGVRRQITDSLKKKPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M112</accession>
    <name>A0A4Q9M112_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0341p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000341">
        <property type="protein sequence ID" value="TBU13783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M112"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0341p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF35">
        <property type="entry name" value="RX N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="778" mass="91813" checksum="68A846BFE68669E8" modified="2019-07-31" version="1">MNICALPTTKKNSYYIFFSNCIRIVSTLLIFRLIISERCRYYFSTNENSEILFFREENSTIDIVDHEFNLILFSNFNSRSLNKKNLVFRYKKGNFLQFEVLKNLLLPNNIKNNNGTIECGFELSYFLKISSDLEELPNKPNSDLFKCMFLTFKFLKVIENKQLLKFLQALILLISIFDKNKTSNFDFNIKELFNSGFLTELDSYIKKNFIFAILNVFMMKYIFYDENLILLENINNPNDVSFFNEHIPYKSLLINNYNIFCRLENILRNPNISFSFLYLLNEINIKSLIINNNRGFIIPDSEFYFSSFSHNIFKSITISNFNDSSSSFLLRFNAFIGNNIEYLTLKNILVARNILNLLLNKLNLRGLVLYDVNITGFPICIDDFTYSIKTLDYVDFSFVDISNTWWNDFFRRVNVSTLILFFRSKHAEENFINEFMKIDSMINISYFSMQFYFRKIHPGFVRALSHLQYLKTLKLKGYLAFENVETNLYKAVEDMKELEYLEMCQVNYNIKSLDLMLQAFKIKVLHLENIVLGKETLNLNFFCNHKSITKLVLRKIKICAFFLKEIFKLENLKTLIIQFCVFEPILDSESLIFLSNNIYILDLYGTNLELIKDYDILGKLDNLEYLYLSFCKIFPEYLSNLSVLCNSRLRMLNFEHGALYPSDLNRIQELEILEELNLFCCSFINCSFGKLGNNCKFFKSLVNLNLSFVDLTIEDFIYCKNFKSLKKLSIELPAFNLIAIRKCLLCLPLEELATNYIAANDKFKNFCHYFYERGIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D1</accession>
    <name>A0A4Q9M1D1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0059p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000059">
        <property type="protein sequence ID" value="TBU20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0059p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="19128" checksum="35D713332C2A2628" modified="2019-07-31" version="1">MDNQDNIANKIKIQDFLDILLIISILDIEKSKERNKFIKALLIHFIIEMPNLKQTFVFDKYYDSYHDKNIRRNILMDLWIFLLDIITFDDKVISGYILQTKKKLLIDFERPMIDLSTNILFLKYFPSKICLRLDRSSLKSLSKILHFEYLGHFWTFISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F0</accession>
    <name>A0A4Q9M1F0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0264p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000264">
        <property type="protein sequence ID" value="TBU17877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0264p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="50" mass="6002" checksum="7848934151A07A45" modified="2019-07-31" version="1">MLDVWLKTHSLKPPCYETLKSKQTHWKKTGGQAVMRRMNECYDNQKHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I8</accession>
    <name>A0A4Q9M1I8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0159p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020179896" description="Lipoprotein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23269" checksum="B2B4F8D87697AF3F" modified="2019-07-31" version="1">MKLSVIKKTLTFLCLLQSSGCSTGYVKDTMLSNSDNDKEVNYSVEKHKNKDGVILLSACSNPDKLQLKKDFVPCGTNRKEKQPGSSSSQSLEDYSEDISGNGSGEKEYLRDATSYYQTCFLRNPREEKTFREKFSELRICGTSESSQDIRLETLDAEKNPDLSPKKESSDSSTNIYFFPASLNDYDNLFRDQFLIPEYWIDDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q4</accession>
    <name>A0A4Q9M1Q4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0138p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000138">
        <property type="protein sequence ID" value="TBU20067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0138p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19107" checksum="2D2B19BBBA94BBE7" modified="2019-07-31" version="1">MGDLLFELGFRVENPKTLPGSLNRITLIEVRITSQDSFQIVKTEKLRKYDLLTNELGLIYKCSVEIIPYVMTWYGIVTKYHKSHIKRLEIPMKKTVETISFDRRRGLEASMGVIMRSEMHEEPTPSLKEAKREEDGAKNLKLKNNTPLISQGGITLEEPTININEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R7</accession>
    <name>A0A4Q9M1R7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0037p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000037">
        <property type="protein sequence ID" value="TBU20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0037p0040"/>
    <dbReference type="OrthoDB" id="125932at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29328" checksum="158AF24F7D8D6406" modified="2019-07-31" version="1">MENLEVNLLNLEKRDSKYKELTKEQRKGILEKLLQQMKENKLTQGASTNFLLPFKISSTVKHTLTDKNVMDRLEFCLSKINLAKNEDLLFDDLYDYVHIDEKWFYETKTMITKNVEFVTAVHCKNMIIDNVIPASKSKSTPEYKRKKIYVQRDNTKPHFSDNDADIVALASPHTIDEFINCVQDALHHLEANMLDNVFTVLQACIESIMLTDEGNGYKIPHLSKEKLRREGRLLEKYVCSKEAYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z2</accession>
    <name>A0A4Q9M1Z2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0120p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000120">
        <property type="protein sequence ID" value="TBU20167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1Z2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0120p0040"/>
    <dbReference type="OrthoDB" id="2507248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="674" mass="79137" checksum="17EED6133626112C" modified="2019-07-31" version="1">MRLITPRENISEEETLRENKSEEERNAEVLRMRALRENESEEERNAERLRMRALRENKSEEERKAEYNDYRCNEVAIVFASRDVETPVDRYILGHLRLEDTVIPKTRRIDYRHRNLNALSYPPLFSYREQTYAEISDAMAMVRKCGKLDLFISMTCNPKYATIFENPDANEKHENRPDLPDRSLDKNISELPNAHILITLKGYNKPRDAALIDKMNSAEIPNKYTHPELFSIITKNMIYEACGFTSYSHYMVENICSKLLPKIKSIHGLKSDGYPLYRRRKKDLVKIGKNHVDNSCVVPYNPYISLKYNFHINVDICASFKLSSLRRTKYIFQPAEQRIKESISNNIDSTLTALFEVYREYTQYCHLKSSEIPENLNLTHDYGELRVMLLKNFVIAYIGSHLFRIFEDRNGKTYKNFFKAAIAKELTTDENFGNETLNDALTMKIQKNIRDLFAYICLFNDVAYISKLWTNHKDNLIEECRRFYEHAVGEFCELCVSYVLNDTNMILNTHGKRCRDFGLEYLPTNLLLLCATFDEQEIFNYEETLNEEQRNALEHIIIPEITKKAYLYKALYYAIKRIERTIISDVIQSNLKHCFLWNNFNTLKLRNNASERQAGLEETAIEILFYMISKDIVKDIFGEVLTILHTICKFSKKVILAHTNEKVDTINQSVLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M253</accession>
    <name>A0A4Q9M253_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0139p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000139">
        <property type="protein sequence ID" value="TBU20058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M253"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0139p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020595793" evidence="1">
        <location>
            <begin position="19"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="764" mass="90497" checksum="20434DBB0B452F54" modified="2019-07-31" version="1">MIIGLIFVIIHFLTIISAQRTIAIHFYESCKSSVTKFAINDWNFPHKYLDSVNESFVELGLDLQNTNLKVFIIDLDTFLLKFFNEEKILEKQQHNIYINEIIFNYQEFVYFYNIVMNFPYSIENINESKYRLIFRIMITLNIKDNKFFEEFIRVLLASLLFNTNSINKCSVVEIPNICSISGYISKKIIVELFKLYFFTEKTLKKLENISVAVKLTDDLNLNFLNLNENCLYLDSDILEDVLKTQKNSKNFFKILDIIFRIHTFNSVFFYKIFYEKKYNLFSGLSLFESLDEIYFFKCSNTDILIESIYEIRGSKPLKTINIIYSKFYVKDEVSWLETLNFEKLNYIAIKSESVSHLDNNSSDSLFGNIFSEYIEEISILEKSPDILYLHSDFSYSDEKATIDLKFYQQKSNLEKLRTLRSRLVSFNYIEISNSFITFDFYVLNFKEFKNLEVEFYNTDIKDFNSRESEIYNNVVHMRIICSKVSSVILSRILLLPSLKKLFFYLCIVTSSKGEVIFIENTKIENFFFMACSSDENNQHLSNFIIKMVALKSLKILCYSRNTNVFVDKFEATNTNFIDLSTLFFWITYYTDSLLTHFGKISNILKFHFGLNYPEGTLNVILSNNFFSGLQKLNLNKINIGREDKYALRKSTNLLRLYFSEGCKFDKISFSDLFDSNTKYLLTKIKLPQIDLTYCDLNFFANLKSLKHIYFYSFTLETKIDYFFRAFSSVKEIELEHILISKNEIIEEFGGRLNRFYYRDNRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3C3</accession>
    <name>A0A4Q9M3C3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0058p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000058">
        <property type="protein sequence ID" value="TBU20518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3C3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0058p0040"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="508" mass="57740" checksum="132E63576B8AB4EB" modified="2019-07-31" version="1">MNATACEPANGMTNLITAAILKESRLMALHSILDSVIVESTNGPICSIAQEENGQRRRIALFSDREEIGDVVDRTRKHLGELINFKVLNSLDRITGEYAESNVPMTITDINVERNHEGDLCVTDLSEALVKKNESLNVYEKKITMHESKKQFRKENRMFELLRVICLKGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSKLYKLTTKCVTKVVQLEVERRGLLAENQLGAVRGVQGAKEQALLNIVLNKEYGNNLKATWIDVKKAYDSIDHAFLTQYIENLNLPDWILKFIEVIISKRKIEISVGLEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRNLNEKYTKVTVQTDAESHSTNHILIIDDLKLLAKDSSTLSAMTDEAKEFLEVIGLEINKEKSATNDKCCVSVYKYLGIIEYSRGIPTRSSFEEVQNKLISRLDGAVHAVLVKNQIHLRPGCKQCFYLPITELRKCLHSVELRSDHMLLQLLDFLKKHKDTSIRRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3J8</accession>
    <name>A0A4Q9M3J8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0046p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3J8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21171" checksum="7F84C80C400009BC" modified="2019-07-31" version="1" fragment="single">KKNKITLIEVGITSQDSLQIVETKTLRKYDLLANKLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPTPPLKEAKREEDGAKNYKPKNKAPLISQGGTTLEEPTNNINEESDLEEEKIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M455</accession>
    <name>A0A4Q9M455_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0022p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M455"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="9960" checksum="813B85BB2B241AB1" modified="2019-07-31" version="1">MSSYYNTVSIISNTVSNSSNSIISNTVSNSSNSIINDIISVIISNTVSIISVSNNPVLYQITFFIDALKFLASKWTEFKRLCENKVLFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4H8</accession>
    <name>A0A4Q9M4H8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0010p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000010">
        <property type="protein sequence ID" value="TBU20908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4H8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0010p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="31628" checksum="3D95DC53271C3355" modified="2019-07-31" version="1">MLEEMTDEKNQILSAIKDSCCKDTDTLFGGIGESQPVNRILRLEFADFSKLDDTVQTAVYLYLYRAELGRGLYNVELRNEDMLLQLLNSWGKIAISKMENINKTNFVLIKGFLKVKYCSEKGVTRRKENELVSVSESLRWLKERKGAETVFNPAINQNNSRSFSLDMKKCLKLRKYDLLVNELDFIYKRSVEIIPYGMTWATVETLSSYRRRRLDLESLLIGIINNMGLKSKLKTKYDTHILEDKYSEGYKININQESDLEKDNEGLNLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Z6</accession>
    <name>A0A4Q9M4Z6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0040p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Z6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="12500" checksum="85DB8A318FCB7B93" modified="2019-07-31" version="1">MNLEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQLILPLKQVYNEEDDVKTENTKNILPLILDGITTAKEPSTNTNEELELEEEIEVVEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW92</accession>
    <name>A0A4V2JW92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2489p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002489">
        <property type="protein sequence ID" value="TBU06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2489p0010"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="30997" checksum="34978474261B4B32" modified="2019-07-31" version="1">MKGQIGIYNKNKNLIYFSSNKNSNTSIVFISGMYGGLFEPVYTKEIYKMCRKKQINFFQPRLSSFPNFGLFTLENDALEVLESLKYNQSENIILIGHSTGCQVIMYLIENYGEDFKERVKYCILHGPISDRNYEEHVNRDLPKIIKEVTNKSESEVFVYENTMYKKERFLDLYRIGGKDDFFSYDLENTFFENLNKIEFKILFIISGNDKFTKESNLNKLKLIKGGEVKIIKEADHFLKQKKYIKKFLNIITKKISRLEKNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX10</accession>
    <name>A0A4V2JX10_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2047p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002047">
        <property type="protein sequence ID" value="TBU10072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX10"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2047p0010"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="241" mass="28068" checksum="DE4F1754AE3C2724" modified="2019-07-31" version="1">MKQMLDVLNFLRVQKIVIGDFKFDNMMLAENLKIKAIDFGHAVFEKKQKRLFSDKDIKNGKNNHKKYLYIAPEIRNGQSCSSIADIYSFGYSSQKYINGITLKDDKVNDFFEQCLMSDPKNRISADLALIHPIFNPLYDFVFCFNSTKNFEISDNNTKIKLHDRVVYYEHPEYSFELHCCSSKNKREFSTFKLNSNEKHLLRKTANQEEAEQRAYGLLGFRAIVGNVVIPIQHLAFSYLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX17</accession>
    <name>A0A4V2JX17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2029p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002029">
        <property type="protein sequence ID" value="TBU10092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2029p0010"/>
    <dbReference type="OrthoDB" id="3047174at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="526"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="939" mass="108123" checksum="E057B9534C683C86" modified="2019-07-31" version="1" fragment="single">RKKQEIYEKHLQEIKKQTEIEESKKHIKIRIKEYEIQRNNLIEEKYKLDSDNFNSIIEAVKKIPISHQTFTMPISLISLLNQVQVNLPKNYQDIDRCIEELFKKKEEFEKKIEPNMLRLNKQIQEIDEKIKEEYKVLEGMPPTEVKVYKEKKIVGVLVGSRGRRVLLGSSNSKTYEIVGSSKTYEIVGSSRKKVDSENIKNEEMKAVNNSEISLKEIKTCDRDVVTIFETLPSQPTIYNNNHSPSSNTFQVTSISLLDSALPSSCLDSSASGISEVQKGLRECLETGGLQFFGTIMGNWVGLEIRQEENGERRRITTCLAEPCSLTDTTLYMNLREKFLCKIKELSEKEIGDVANVSDAARIIQAAQVCYDEITRNEKPRSAWKENIESKISKLVLFKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDISEALKKITMHESRKQFRKENRMFEFFRGRFYRGLSERVESEHVVNRDEIVITYDDYSIPFASDNHSTTFPLLDELKLTNLYKYLYDIVKVICLEGTPQADWFYCGITYLIPKGTPKTGSDYRPITCMSNLYKITTKCVTKVLQIEVERQGLLSGNQLGAVRGHGNNLNAAWIYVKKAYDSMDHAYLTQCIENFKIDKGIRQEDSLSPLLFGLCMDSLSRKLNENYTKVTVQTDAESHSTNYLLFIDDLKLFAKDSSTMSAMTDEAKEFLEVIALVIYKEKSATNDTCCEDTSTLLEGRSVFKYLGIVEDSKGIPTSKSYEEIQNKLIVQLDDAVRAGCKELLYLPRKELGEGLHSVEFKSEHMLLRAAILKVENINKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKNGSVRPRDEADRNVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHKEVYDVYIYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB5</accession>
    <name>A0A4V2JXB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heavy chain of myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1330p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001330">
        <property type="protein sequence ID" value="TBU11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4V2JXB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1330p0010"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="1"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1353"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="729"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="848"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1356"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1619" mass="187120" checksum="015239324231DA51" modified="2019-07-31" version="1" fragment="single">AILHLGNIEVLQHNDQAYINNTETVEKVCNLLKIETKKFLSTLLHPISMAGTEKVINMRNKNQVINIIEALSRTLYERLFDTVIDRLNYTLNSKLDSNKFIGVLDIAGFEIFKNNSFEQLCINYTNEKLQQFFNHHMFVLEQELYKQENIKWDYIDFGLDLQPTIDVIDKSSPIGVMSYLDEECVIPKGSDKTFLEKVISGIKCSGGDSSSSRDSSSSRDSNYKGDRDSKDYRGVNNLSDKQQGVNTSSKKQQGVNTSSKKQQGVNNLSNEQHPVNTRSDTLHPVNNNHIEQHPLNTIKHPFNQYGNIFGPLRLKNGFFIKHYAGKVEYLVDGWIEKNKDTYFDSLSTLLLTSTNLFIKDLFDCYISSTKKGFFRTVSQRHKEEIYSLMTQLTNTSPHFVRCILPNIYKKNYNFDLSVVLQQLRCNGVIEGIRISRLGYPGRMTFIEFKKRYSVLIRKRSKIVNSDRLEGNSNIVEGDMDIVEGIVEGVNNSTNKQQGVSDTTNKQQGVNNSTNKQQGVNTSTSKQHPLNHTTSKQHPLTNTTTNNTTTNNTTNHLTLKDSVFLILSTLNIPTNSYRIGITKVFFKQGVLGDLEDIRDNIIISLSKEIISLYLKVLVIRKNNKKKKNEKNIKILQKNLKILLNIKRWKWFKLYIKIKPLFVVTHYELESKKLKDIIYNLNIENNNYKSYNDKLNCNICKIEKELESSNKLVEEWKDKLLYLRGEYESRIVLLESREKEYESRIMLLESREKEYESRIGEYENSNRLLESRIEDHTNTIKEKDTLIKEKDTLIKEKDILIQDLNTNIEDHIKIIKDKDTMIKDRDTIIKDKDTMIQYLNTNIQDYTTSVNNLQLLLNDKTSELNTIKEKHNLTLKELKDKEMGNKIVEYENKIVGLENRIVELENKIVELENEIVEYESSNKEYEDSNKVLEDKNKELENSNKVLENTNTSLSNTNISLSNTNISLSTQLSDLSNTNLSLENTNISLSTQYSDLSTQVTSLSNTNTSLSNQVTDLTTQVTSLSEVNKELKNNYNFICDLKGEEVEEVKEENKVLNKRCNDMKNKVIELEEENKRYKDIECSNRGVISVLECKVDCLERRCLVLSSRYGSGNRLDNESNTNLYNNTNNNLYNNTNNNLLNNTNNTLYNNTNNNLYNNTLYTSVLGSVDRCLRVVEKWVGRCVRGYEEVYRRVLNEYRERVGVLEKEINIMKIKVEGVNKENSRLRVLISSMNLSSVLRGVSDVYKCYIELEVLISRYVKGVLSIEEECKVLGKEVCDKRGVIIELESVISKMERGVSDMVSMEDSVEDSIGMLSVLEGGDKSRGMLGGVNDNYMLGGVNDKSSVLEGVNNKEYDYKGLSNNTDTYHPVNNQSNEQHPLNISSNDYNPHSTSNTDIPNNNISDISNNYIRDNNNNIRDNNDISNLLYNHQPSSNTNTNTNTNTNTTTNNIFVLLGIERENTKILEMKNRRLSEYCMRVVKENEKYKNININILIREVLISRNIIRGKSITIKNMKNDIEVLRRENIRNKEYISEIERDMCIKDGYKSREGDYKMLYFKMCGDLRVMREEREYMKGRVFCMEEDIYRMRMCVVEGEGRVKGLVREISEEKEYNEFLRKIAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF9</accession>
    <name>A0A4V2JXF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1112p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001112">
        <property type="protein sequence ID" value="TBU11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1112p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26100" checksum="8B0796A850E9E16E" modified="2019-07-31" version="1">MVSKRNKIRIALGVVGSILAIFGIICVVGYIKAGNVIKSFEDDYKKFLDLEDDKKFTSLVNLYNYGYFYSDKVVSFFGFVVKEHKESAVKMAKEALEKKHTKKKEELMESFGFHQHLIDISRLEKVVGDFGLLVRLGFCFKGYHPIKPTYALSAFIHKTIKNPTKDEVNYAVLDIVDDSVVKVFDVKYDDKGPKSIPSAKKFKFEASKNGISGKAADFIAYICYKVKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM4</accession>
    <name>A0A4V2JXM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0774p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000774">
        <property type="protein sequence ID" value="TBU12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0774p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020516783" evidence="1">
        <location>
            <begin position="31"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="461" mass="55428" checksum="1AAAB11CC11F1546" modified="2019-07-31" version="1">MGMFNQEPRKPTLLFVILFILVCCLKPIQNNSLDTQEIIHLAKEKRTEIENLIHFEIEIRPEEIIYEEIDTYLEYETKLLECINSNAFESYSKNLNEKSLEYMYESLDFIIGNRKIFLLRNNTATEKYNEAMTKIKAELELLVSYISYFLSSNICNCTRSHFKIINEIQHLINYLKLIYLRIHDSMKKVLDCETKYKKLLENHHFLLFISSRKVHNDKIREFKAKIEKIRVNYDDIKDEAARAIITYRNYNFEEIIIMQYSQNNFYALFITNEIFSNIYSYIEIYEDKNLTNKTIFKEEVVKFYGLLGYVRIYISTYKIFRSNFVELLDKTTKCKKYISNIYARIEKSTNSLQEYAEIYEIDEFKDRFKGFLYTTKQELADKISEIMNFEKEQLAKIQKIIDYNNLILKTYNNLKKNHRLINIQKKISVLEVFQQEHTDFVHRMQKNLNDILSYALEHGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX5</accession>
    <name>A0A4V2JXX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0428p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000428">
        <property type="protein sequence ID" value="TBU13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0428p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="18597" checksum="A8C5782F8AC0D4B2" modified="2019-07-31" version="1">MPNSGLDTLPSPNTPLPSLVEVSACKPSYNKTTPLKLFFCSTDKAHNEKFGWVLSLDTLKKLFKSLADAVDIVQAAQVCFDKQDKIMREFNFVLYSFNQGKEVFEYLREKNQMHKVGSNSEERNLSERVASQHGISRNKTDSFRSKLATKTMTQSCMPIIHSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY7</accession>
    <name>A0A4V2JXY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0360p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000360">
        <property type="protein sequence ID" value="TBU13692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0360p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="51294" checksum="D99C13B0EE08CFF1" modified="2019-07-31" version="1">MRGSVRRLQNYSFIFYLLAMFILRGNLYTIEEFDKAISTKFKEMYQVNEEILKYFSDSDFYDIRIKDCCMPSELIELLSDLIRSSNTTFFNIFIEYRCGMLRSSKNPENENIFELKKFGANNFAFGINYIDKKNRAPLYKRLQIGVSKKYLKHLLNTLFKVTLVFRKFYTNIIEFANYCYRCSNANYRFMIFDPELGFRNIVGFPDKKILGRYKKSNITYKQVLHTKLKFSGKLSRHSGGMEDVESILKEKNEIFLKLQGKYDIKSYWRFLNTLPNAELSVESNTDIFSYNLKIFSSLARQRPCKEVAVCFIRELLVEKDYFIECRLLSEESIKDNDFQREYTYNSNFNDQICILKLYFLQNNNEEKIFRLYSSLFKTNEYFEIFTDGEYNITRVVDNVEKSWPSERNASLNEYEWALIVILGEIWLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY23</accession>
    <name>A0A4V2JY23_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0270p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000270">
        <property type="protein sequence ID" value="TBU17670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY23"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0270p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25846" checksum="A9077D20738C4807" modified="2019-07-31" version="1" fragment="single">LNEQQFYDTLRTLKIKGTPLTHLEIEKILNFSRLENLKLHTCNLDSSHLLNLNKLISKKILRRLILTNNKIKNIPITCKGMFNDLEHIVLDRCGLYAGSVSLFFNDTKSNKISFLDLSHNSLNRADLIVVSGLIKLQVLKLNGINLQEDARLNNLTTHGLTKHLKFLEIKELTISAKDILFLSKFKALEKISLSESSFECLKNTKVRICCSNFDVDSVYELEMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY35</accession>
    <name>A0A4V2JY35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0249p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000249">
        <property type="protein sequence ID" value="TBU18229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0249p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="9052" checksum="60C157D645452538" modified="2019-07-31" version="1" fragment="single">MFQLSETQPQQTLFNIYKGIKEFLDPERQKISMLFIPAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL4</accession>
    <name>A0A4V6MVL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1185p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001185">
        <property type="protein sequence ID" value="TBU11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL4"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1185p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="52188" checksum="35B8895EB28B0026" modified="2019-07-31" version="1">MYFRDRKLNKLILKVLSFEILLFYVSYSLSSLPNPITLIQDGFSETYKTIKYLGSGVQGSVFLVRNIRNGEEFALKIQPINARYDCHRIAELFKNYLKHENIVEFYAYGKDKRNEYLLFEYLPITLEKYLKEGNVALINFLFIMKQTFDVLNFLQSLKIIYLDSKFDNIMICEDLKVKLKDFGLANFEKDQRNFFSSFDMINKRHETYRNRDLAPEVRNRQRYSCNADVHCFAYICRKALKNITIKNYQIMNDADDFFKKCLKEDPSKRITADLALLHPLFNILYDFLICFSNLEDLEISKNETKIRIKDKILYYEHPNYGFELHCCCKNEKIEFTKLELPSKQTHAEEETGNESQTKQRAKRLLDYRVIIDKEVLPIQHLTFSYYNELKNIFSGLRVEQKQKSNRGMWKYIIGISVVVLILGAGLSYYFFFHKKKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L5Z9</accession>
    <name>A0A4Q9L5Z9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0369p0030</name>
        <name evidence="10" type="ORF">CWI38_0807p0010</name>
        <name evidence="9" type="ORF">CWI38_1392p0030</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000369">
        <property type="protein sequence ID" value="TBU03028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001392">
        <property type="protein sequence ID" value="TBU11090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000807">
        <property type="protein sequence ID" value="TBU12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L5Z9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L5Z9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0369p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0807p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1392p0030"/>
    <dbReference type="OrthoDB" id="2186857at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="141" mass="16894" checksum="6B6F01A4B079177E" modified="2019-07-31" version="1">MILKILGFNRKKEIRITRTYFKISIDDKTIIKEILLLKEPDKIIKKEKFTILFEKFASIILCFVVDNSENLFYISNAMNTFVIVLDKYFKRVCELNLIYSFDKVHYLLDNYICNGKVIETDEITILNKMNIFQEKILNEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBV5</accession>
    <name>A0A4Q9LBV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative pre-mRNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0027p0090</name>
        <name evidence="10" type="ORF">CWI38_1553p0030</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000027">
        <property type="protein sequence ID" value="TBU05288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001553">
        <property type="protein sequence ID" value="TBU10781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBV5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0027p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1553p0030"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="262" mass="31376" checksum="B78B5F2B0FACC556" modified="2019-07-31" version="1">MQLQIKGFSPTLGHKDIREHFTKFGRLSDIRLKKTYGFLEYEDSEVTKQVLNEKHIINGFYIHVETCDSNAEFEGRREFEGRREYEGRREYDGRREYDGRREYDNRREYDGRRHDRYEHDRYDRHDHRYVCDRCHPPHKENYRSNSDGYYSHPGNKYKIVLDDINPKTTIYDLKDLARSYGLDPVYTRVSNNRKHGIIEFKNTEEKEKGLRILNGVKVTGSVVRAREYRSSGGEVYEGEESERRYGREGKEVYEGTTNNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEX6</accession>
    <name>A0A4Q9LEX6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2571p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 9 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="PITK01002571">
        <property type="protein sequence ID" value="TBU06464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEX6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2571p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="40"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU06464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="25212" checksum="A1DF1226B52FBF94" modified="2019-07-31" version="1" fragment="single">CESMQFMAICALITVCDKNCGCTGCEGILNESYSEKNNSFPKNNNILIDESCEDIFAAKNLPGKSMNTKNLNGCDICKGLSNSNTENKFKVFAVHGGLSPKYDQINQINKFNRMLNHSNLHDLLWSDPSEEPGYKKNTRGAGYLFGEDIVNKFCKNNNISLIVRSHQLVQDGFELKFDGKLANIWSAPNYCYMCGNLASVIVLKKGGFEEIIYDKCDNQLGNNIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFN1</accession>
    <name>A0A4Q9LFN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2511p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002511">
        <property type="protein sequence ID" value="TBU06764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2511p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8735" checksum="0FCCD04B1436AAF2" modified="2019-07-31" version="1">MSSRNFRSKKDRNYHNFETDQSKEMDVIPDFSSRPRNICTKSNGKLSSLKKIFFSNSKSRCPKSHFKRTVFIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGS9</accession>
    <name>A0A4Q9LGS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2420p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002420">
        <property type="protein sequence ID" value="TBU07303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2420p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="26035" checksum="5C01BFFCAAEC0BA7" modified="2019-07-31" version="1">MLIKGEFKEIKFYVNSDIDSVNYKNKKEVESFKINVSDNDYRGSSNYRGNSKEGENSRGGSDNKGSMEEGKEEVDNNYKGNNKGNEVDNKGNEVDNNKGKNININKGNNSINTPSNTSGNEDVDCFGINNVHINEIVLRNSKYKDCISISLLLNGNENSKLYYLSFKGEKGNEMAKAVVTKYEARSYEDITCKDKGDKDSRLKVGGVSDKDSRLEGNRLGYDEDSRLEGNRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGV7</accession>
    <name>A0A4Q9LGV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2441p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002441">
        <property type="protein sequence ID" value="TBU07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2441p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8624" checksum="4A8ACBF64C2674EB" modified="2019-07-31" version="1">MHSVYSTERTVETISCDRRRRLEASMCVIMRAEMHEEPTHSLKQASREEDGAKNLKAKNSAPFVSEEGTTIENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHL0</accession>
    <name>A0A4Q9LHL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2375p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002375">
        <property type="protein sequence ID" value="TBU07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2375p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12896" checksum="C901492A920F23FC" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESLERTSMGVIMRAEMHEEPTPSLKEEKREEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETAVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIM8</accession>
    <name>A0A4Q9LIM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5094 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2314p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002314">
        <property type="protein sequence ID" value="TBU08039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2314p0010"/>
    <dbReference type="OrthoDB" id="2187979at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031519">
        <property type="entry name" value="DUF5094"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17015">
        <property type="entry name" value="DUF5094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5094" evidence="2">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="341" mass="39112" checksum="C0DC655D24D18D8E" modified="2019-07-31" version="1" fragment="single">MKTPRSRITFKTPKKRNIKTPLSLKQSRGSRESKESRDNKEVKERRDNRDTSLSLKHKDNHTVLTENKKLDSSIISTENTLSSLLESYREENKFLRNLKNDSLIFQRLIGLSIKEVEGKYECTHTVTVKGVTRYIVFLLIPDTSSYVYKPVSSCNVSLPEYLSDSICFTEEHIQMGVRDVLEDMLQKGVSYKESNGIIVKGVLLIKSNIEGVIKVVLVIKSNSIVVKGVLVIKSNIEGVRSLGRTVPKLVNKMDADFYEIDRVGNSLLEVTLEAVELDKVFDIEGNNKRLIYYPLHGYNNQQFQLFLDYSGAYRIMSNGLCMEYNELELAFMRETCRNDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ11</accession>
    <name>A0A4Q9LJ11_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2393p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002393">
        <property type="protein sequence ID" value="TBU07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2393p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10641" checksum="C0BC4BB72ACC94C6" modified="2019-07-31" version="1">MSLLHCNLILNDLNIIKNFEVLEDLNLTGCKFSNFGFFRLGSDCAFLNSLKILNLSDVEINIIDLSYLRNFKNLIKLSLKIHGSYYLQKRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJR5</accession>
    <name>A0A4Q9LJR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromodomain-helicase-DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2302p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002302">
        <property type="protein sequence ID" value="TBU08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJR5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2302p0010"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="446"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="868" mass="99754" checksum="37F13AFA69D3A9A7" modified="2019-07-31" version="1" fragment="single">MTSTASTNSDQSEETSISSDSVSFHSSSSPQPSYGLPTLKKRGRPRKSQCSNPALYNSPLGYNYNLRSQYLYRQVSSYPYPYPSSMGHSNPSYYGNIFHNTPYQYNYPPMYNNTPYNTPYRFPPYYSPYPNYQIRPPPTPPTHTTTPPHHQNPTTPTPTHPQPKKYIPVSPVRGRPKRTRKSAYIPSQPPLKIQEEEEIELEQISDTSSDIEKLLSHNPSQDTYLVKYKNKSYIHCSWVSKNTILQTRSGSIKIRRFRPKNIPFDPEYLIVEKILLFEDTRCLIKWKKLSHELSTFEETEKVKNCENYTSALTEYNRRVEKAIKIKRSRNNRYESNIDSSISNRIDSNIDSRFDSTNNNDNNLYNNNDNTNNNLYNTNNTINNLYNTNNNLTINTTINTINTNAFSYKPVNYRPPRDEMLRFEKSPSFKNNNTLRDYQLEGLNWLLNRWYHRQSCIMADEMGLGKTVQSVVFTNTIHTIHKNPGPYLIVAPLSTIIHWEREYLCWTDLRVLVYHGSASGRDVIRNYEFFYKEDITLPLFDILITTYEMCMSGLNHLKDINFCVGIFDEAHRLKNINSKASISVRELNIDYRILLSGTPLQNNLGELWSLLNFIDPYKYDDCTHFLMTYTMNKSEDVERLQSVLKTLMLRRMKDDVEKSIPVKEETIVEVELTMIQKRFYRAIVEKNIEFLRKGDNAPNLLNAMMELRKCCIHPYLILGAEEKILGEWIYKQRSKVVEVEGSVGKGMLEGSVGKGMLEGVSDKGIDEEGVSDKGMLGGGVGSVVEGVSDKGMLEGVSDKGIDGLDPINNTTNKQQGVSDNDSELEGVIDKDSRLEGVRDKDNELEGVNNSTYNQDPVNTNTYNQDPVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK62</accession>
    <name>A0A4Q9LK62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2363p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002363">
        <property type="protein sequence ID" value="TBU07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2363p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="18475" checksum="FD29252063FD35E9" modified="2019-07-31" version="1">MGESIGSGIRNGYMGEYIGRSIRNGYRGESIGSSINKVCKNGIKNVLRNYIRTNIKSTLRTPVAINSTDSQVYEPDPLSEPSKEKRKGIYNTTFAKFWGKMGDAINDAANRNKNSAKKMGRGFKRRYKKAETGVSNKIAAAQGNVKKYIKSKAQKASDGIKQKIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKN3</accession>
    <name>A0A4Q9LKN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2260p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002260">
        <property type="protein sequence ID" value="TBU08456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2260p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="47412" checksum="DC5810FDBA8E6037" modified="2019-07-31" version="1" fragment="single">DNSIDLDIKNNNQKSNKTLDQKFSIAQSKSGSLENKIFINNNEYKVIKKFLILKNGVVEVDFFTKDLPYLVYLDKEIKEESNGSNEENIISVIVENVSAMKILKRLYPSINIRENIISGPSELFLDSVFCDINKMGINCKIIYIFNKFKETIKSKKICITAKFSIFIEPISDDKNICFDFENNKLIMTKETIYNHFLNSLNESDNNIESNKCQDKKNLKSCELTSNINEESKNDKIRLQTYKGNNLYYEIKNTDKVITQASKNLSKLFKNFINQGPIVFQEVFGVNISVNFSKNTSKTGIYFHKECKKLFRSDFKILEPIFYIEILIQKHHLNFIKSFITSQKGKINDTFDVPYTEYNIIRGEISAFNSFGLEAYIKNTAFCHIEKIIIGYSEVPYGFEEYKKLNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL07</accession>
    <name>A0A4Q9LL07_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1426p0010</name>
        <name evidence="10" type="ORF">CWI38_0313p0060</name>
        <name evidence="9" type="ORF">CWI38_2242p0020</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="PITJ01001426">
        <property type="protein sequence ID" value="TBT99197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002242">
        <property type="protein sequence ID" value="TBU08586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000313">
        <property type="protein sequence ID" value="TBU15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL07"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LL07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1426p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0313p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2242p0020"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT99197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU08586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="168" mass="19658" checksum="6CF7F844C6EB9275" modified="2019-07-31" version="1">MRKETLYIRILLTSICLWLAIITLKSYLKRTNKNPRLVKNNVKDNQSYAFTESKVHTGAMTKQEIRKRLGNSTWVLLHTMAATYPAFPTQEHKKDVLKFLILLTKVFPCGDCAKHMQKMFSDYPPRISSHDDFVQWLCECHNMVNERLKLPQFDCSKADEIWECGCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LME9</accession>
    <name>A0A4Q9LME9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2142p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002142">
        <property type="protein sequence ID" value="TBU09519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LME9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2142p0020"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15499" checksum="40C4552419E40460" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPIPPLKEEKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMR2</accession>
    <name>A0A4Q9LMR2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2224p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="PITK01002224">
        <property type="protein sequence ID" value="TBU08741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMR2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2224p0010"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU08741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="20007" checksum="35B73814C846639B" modified="2019-07-31" version="1" fragment="single">MTKKDFPSKYIYGLYSKFSRNISQTPMKINGKLLYEKSISDFCKSIAEHFKAKNVKFISCGREDANVRMVGKRPFLLEIEGGVYNEEKMNINLDKNIKIFDLVWMKDEIKFIIKNAEMNHYKVYRAMLFIKNLNIHNVESNIPPINLENDNQFSYNKAILNMKEKVETFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNT0</accession>
    <name>A0A4Q9LNT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2018p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002018">
        <property type="protein sequence ID" value="TBU10103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2018p0010"/>
    <dbReference type="OrthoDB" id="10624449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="32058" checksum="62648C470F295DB3" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQKEKIIKAANRASEVDVVIRECKNDQGIPQPSSYASSTIINNTSIPPSEANTNTKVCLLNTIPSPSNPMHSSTVTPRPDIAASGPNLCTIPISERLVVLRSLLRSIEAERQEFIRCVFFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDTARFISLREKYLSNIKKISEEEIRKVVVRTRKLPNELVDSTVLDLINRIVGEYADSHVTMTITDFVRIIQTAQVCYDDETRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP77</accession>
    <name>A0A4Q9LP77_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1989p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001989">
        <property type="protein sequence ID" value="TBU10144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP77"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1989p0010"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="46164" checksum="6B7C243751F0D340" modified="2019-07-31" version="1">MASLTLKDIKIQKSHQLISEPIKFDLIFDCHREIQDDVEFTVIYNGDAETEEYDQVLCNELVGPIPKGKVGFSLETVPPVVDKIPVEQLFGVTSVIIIGKYHEQQFIRIGFFVNVEYPSIPNSELTFYEENEEESDLEELSEESSATEEEENIPDLVADEKENNFEEEKEKNEENLAEIIEEIKNANEETKNSNLQIQSEISNMNEEVIEKMKEEKLVSDEKSINPEISGEVEESNLKDILTENLSPKDEAKTEEIPIENRISINNHVLDKTLIEIELVEPPLKTVFTIKWSENDESLCESSIYDESVHTEENEYQIDENSSKESEENINEESHHSSEKQPEENITEDSEENQTEKSKNTNQISKESKKSIKTEKNKSKDQNLKSTKRPNKNETNKKSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPH1</accession>
    <name>A0A4Q9LPH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1847p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001847">
        <property type="protein sequence ID" value="TBU10328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1847p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="549" mass="65500" checksum="23713EA76BEF2842" modified="2019-07-31" version="1">MNGDSNFFNEYNKNVVLSHNTKKNDHSDMTFDSSRTKEDINREFDDIKLKICGECCDIYQNLRIYNKYFGEEKCIACNKTERVCLNHLLVFHSPKTELLFKNEAAKSSKKESKASDDMPFVYNITCRPDSEMYLYISYFLNKSQKLKDLLKKNPNMPITFEELKLLNPSLLNALIEIIRIIQIENLDFVIYEKELTFKHMTVNKTLNNNLLSTELYVNIIVSSFEEFDLNKFREILNEISYFIYKIQSDWMDWGKEERLIRKEIENFLNHINSNIETDFFLKIRTFIHSIYYDIFLSNRKPERLIEKYVLLSSLMACESIYIRNHHNYDSLTNQDCQLDIKNNKLDLAKKLNEIMFRIISCVTYDTSYYISFNLLAYILNDLTDIIHKEQNEELRNACEIIKDFHLMFFFLPRIFIEKFTNLTGIIIYMIIIAHRENTFKFGFKDYFNDNFCSLSLKDCYDLVIAGYISFLTNCKLLVHIKRTDSDNIKFKYKIALKILNEKIEKENIIMLNNTKYIKIYKDTSREVFRSIKEYINSNFQCIRSINIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPM4</accession>
    <name>A0A4Q9LPM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L18A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1984p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001984">
        <property type="protein sequence ID" value="TBU10147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPM4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1984p0010"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="4">
        <location>
            <begin position="539"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="629" mass="73109" checksum="6FA058EFC18F9ED9" modified="2019-07-31" version="1" fragment="single">ISLLNYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVGNNNKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPRDEAGFCYIQDRNVIWGAEGMSQHCNQSRKTVDHLAMRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIKVDTRIKTDVKIRCNRPDIFILDKRQNRITLVEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPFVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETIFFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPSLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTTEELELEEEIEVVEILQEFKIFGSKLPTEEEKEPQIYVANIFAKNDVYARSRFFNLLNTKHKIKSTKACVLKVVPITEDTSEMVVKNYGIKFYYRSKRCFHNMYKEFRAISRISAVEKLFSDMGGRHEVKNDMIFIVSVSEISDEEVKRPGVKEFCGDEVMFPLFEKNINKKSCTFVPKDSNIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPV4</accession>
    <name>A0A4Q9LPV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1733p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001733">
        <property type="protein sequence ID" value="TBU10479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1733p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020282709" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="16880" checksum="85D00EE81CFA88D2" modified="2019-07-31" version="1">MFFKFILISNFLSEYFRGVEGVCQHCNPPRKTVYCLATRCEKMYGKAMLDGIIKLYMHTLTPIKKISFYLRMDTRIKSDEKNKITLIEVGITSQALLQTVETEKLRKYALLANYLEDGQNNSFDRPRGFIKLISFVNNSINQHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPY9</accession>
    <name>A0A4Q9LPY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1705p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001705">
        <property type="protein sequence ID" value="TBU10519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPY9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1705p0020"/>
    <dbReference type="OrthoDB" id="2190092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="23845" checksum="AE54AD680CFD905E" modified="2019-07-31" version="1">MIIFNSKAKDFLCIILHGLNSSSSEISYSFTSIAKKLEFVKFIFLDSDRKKVRIYGNEIVNAWYSLNSYSIFDSSDINGFQTSKNRILFEINSHNFHPSKVVLVGFSQGAAMASYVALNTDFVFKKVIMLSGYLPMKLEYSNTTKQNLMMIHGLFDGQIPYFIGIYSRFILRYFYKQNVEFVTFFGTHVIPKKIEKIFLGIFKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ38</accession>
    <name>A0A4Q9LQ38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2130p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002130">
        <property type="protein sequence ID" value="TBU09655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2130p0010"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="19280" checksum="64A588485794520C" modified="2019-07-31" version="1">MCQHCNQSRKTVDHLATRCEKMLGHDYTRRHKEVSQLVQEILDNKYAEIRVNTRIKTDVKIRCNRPDIFILDKRQNRITLIETVKTISFDRRRGIESGPNAEESWERASLIDNEENDVKIENTKNILHLILDGIITAKKPSTNTNEELKLEEEIEVIEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQB0</accession>
    <name>A0A4Q9LQB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2119p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002119">
        <property type="protein sequence ID" value="TBU09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2119p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="163" mass="18667" checksum="60B5F0782488A8A5" modified="2019-07-31" version="1" fragment="single">FISTDGIYSIWKSKILEIFNNAPLFLYSILPEILSIKNLVKEDSKSIKPQGGNYLVTLLIFEAIVGNPSLNNEKINMKNQKIEGFTDLTICSQSLSGISAYLRMLLEDIERMMEILKELKNTYLPKESYHSLLHSVEKDIESLKKSIFENCEKESLESNKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQS1</accession>
    <name>A0A4Q9LQS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0414p0050</name>
        <name evidence="2" type="ORF">CWI38_1524p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000414">
        <property type="protein sequence ID" value="TBU02792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001524">
        <property type="protein sequence ID" value="TBU10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0414p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1524p0010"/>
    <dbReference type="OrthoDB" id="2194671at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="465" mass="55632" checksum="93815A4554FA0D15" modified="2019-07-31" version="1">MGYLETSKTKEIIELLKRYSTLKIYCTNNCHSISSVHILISILKRELIKFEVNIVTSHSDFPKENTEFKIIIDIPVNVNYECIGIGKVIGDENMIILKCEYSECSCDIKYTDSLQTMYSFAQKMNYLNNSILWNSLVIFNFYKIYFYEKVRNFDFSEKENYYEDYDEDSSYESAHDIENEMLCLVCKNFYKELIIEIKKTNQKNSLEKIFYLRKVDIPFIESNNIFESLSFFLDFILVKKLYLKSNIFKDYKIYEFLAKLGISIKESKDCSSNMTERSQNLIKENINQNYIYEYKFNYDFKISLLESFYVLTSTMYTSKPLYSIFCFSNPKYIDVNSVFNFYKSINYLLRINIHRLKQVGPFRLLSIPYLNNEILENYDNLSWIKIFHDLIKIFLQKSKRANLEIIILIEKYKETQSLLYLPNKKKKYLLRNIENESLDIENTIFIVQNGLLKYFFENLFGINYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQW7</accession>
    <name>A0A4Q9LQW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Man1/Src1p histone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1486p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001486">
        <property type="protein sequence ID" value="TBU10899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQW7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1486p0010"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="466"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="783" mass="91184" checksum="6AA9699D022907A8" modified="2019-07-31" version="1">MRKHHTNPTKQEYLNKDFNYKNLTKNQIASILSECNCTVPNIPTTKKNEFFKIYKTEIFDRIEELKSKYLNVKPDGRDIERVDKVRGDSVKEDRDRRDSIKEDRYRRDSIRNIANTGDTGDSRNIANTRDTGDSRNITNTRDITNTRDITNTRDTRDTRDIQNTNTRDLYKSGNESVFTEDNPFQSETDVSKTPNRSKLGNNFVRLSVNKEKRHKKREENEESEESMSSSSKDYDSNSSRDSYKESKDYSSSPLIKKRGRRVKNVSPLSNKSGDKRVSLSKSPLKYKRESLGRLGDRGVNDKEYDYKGVSDRYVDNPLTSNKSRRSIDRGVSNSIDDYKGVSDRYVDNPLTSNKSRRSIDRGVNDKERDYKGVSNSIDNNTPLPTRRSTTPSNTINNPYVTTPLRTNKSLHSISQHSHPIFFRNPQVRKSKRNIFLFFLFLIFLTCYLYVKHFCKYCTDFEEKNFIKNFCVPKPKNLILFENEFVCKKGYIYKKKYFCRNLCVKDLSVVNKIRKSVDFIVGELQICNWKYIHGIVDSNKVSIEEIKNMCDMIFGVFEGESNNSRDNTKSSTRDNIKDNTKSNNNNTIKDNKDTNTKDTNTNNTKDNKDTNNTINGNIPFNDILVELEGRKGFLRENNNFYTFDVKVPIGLFIKFYILKIFKILIIPIFTIFLIYLIFKYEIKKRKKNKKNKEMADLLVKDILEALSLQLLHNSKDKSVISCVALTQLKDYFGIEDDVWVEVVGKIRRNSNVRENMSVVKGEEMRVWEWIGPIIGVHGKRMSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR56</accession>
    <name>A0A4Q9LR56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1578p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001578">
        <property type="protein sequence ID" value="TBU10737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1578p0010"/>
    <dbReference type="OrthoDB" id="2192717at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="18022" checksum="EBFC94B091900DBE" modified="2019-07-31" version="1">MYYGDQKALGHYYNRRYNELVRCLEFRLLNDYKLKSSKRINSHSVQEILENEYAKIRITLIKVGITFQDSLQIVRTRKPRKYNLLANEKIHSIDCTQEEGRKERQYFLLKEAEMHEEQISPLKHASNQEDSLKTKNNTPTISEGETMLKKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA0</accession>
    <name>A0A4Q9LRA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1474p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001474">
        <property type="protein sequence ID" value="TBU10924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1474p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12490" checksum="A89B97EC7FFDEE8A" modified="2019-07-31" version="1">MDLDDSSYNIAMTNRISEFTRKNLKISQAEITQKLEALFNYNDNDQTIRNPQIKEILLGLMHVMRISSDPGTVTSSCMHPMENKKSYTTENMNGCYGKGSEMFNIISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD0</accession>
    <name>A0A4Q9LRD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1527p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001527">
        <property type="protein sequence ID" value="TBU10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1527p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="24100" checksum="6DA99A6DF34408F6" modified="2019-07-31" version="1" fragment="single">QYFQITDFFARIKKEICKISFLCSDLNWETYMKPKNIFDDSNSYKYYSTDLDYKYQDTILKMKIYKFSVVKDFAVITSIQNIKEIGLCRFSTNNTSKKNGKHVQSLCLYLFLYKIDISKSYYPSFPYISLQIEYDLKIVVNINEKMYPDDIIYKIKCLRNIATDSYSIKSIQSNVELENITSEKRKLIEIFQNITAEQERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK6</accession>
    <name>A0A4Q9LRK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1880p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001880">
        <property type="protein sequence ID" value="TBU10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1880p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="15508" checksum="00163611BE6430A1" modified="2019-07-31" version="1" fragment="single">MGRKKNVGSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMTLRTIFDSVTADPKEWPRIVFFAVQTRFERMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK9</accession>
    <name>A0A4Q9LRK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1351p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001351">
        <property type="protein sequence ID" value="TBU11159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1351p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10095" checksum="72ABFD5E884743ED" modified="2019-07-31" version="1">MVESILVEEGVSYKGVSYKESEVIEGVSYKDYKDRGYKGDRVVDYRVLVIIIVTCYKGVSYKDRNNNNSNVKGVSNNNSNVKSVSNTTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS64</accession>
    <name>A0A4Q9LS64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1280p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001280">
        <property type="protein sequence ID" value="TBU11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1280p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="10782" checksum="269B376A31ABDB1F" modified="2019-07-31" version="1">MLEGIESNNKYIYRGVNNRDNNKYNYRGVNNREVANKRVLIIESNNKYIYREGVNISSKGVSINSKGVIISSIVANKRVLNISSSKKEGVNISSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS90</accession>
    <name>A0A4Q9LS90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1266p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001266">
        <property type="protein sequence ID" value="TBU11324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1266p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="291" mass="32609" checksum="BF184A14D524EF5D" modified="2019-07-31" version="1">MVSKRNKTRIALRVVGSILAIFGIMCVVGYIKAGNVIKSFEDDYKKFSDLEDDKKFTSLVNLYKFCYFVSIKEESAFAFVVKENKESGVKMAKEALEKKNTKEIDDLILSPYSMKGTGMDISKFDKVVGDVGLLVRLGFWFKGYHTIKPTYALSSFIHKTIKKSKAKEESFAFLDIVDDSVVKVFGVKCDANGLKSISSAKKFTFEASKNGISGKAADFIAYICYKEIFENEDAKIRVAIRLKTDVNIRHNSSDIFILNKSRKGKPKLERLESGPNAEDSRQKAVMGVIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS91</accession>
    <name>A0A4Q9LS91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1208p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001208">
        <property type="protein sequence ID" value="TBU11433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1208p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020462910" evidence="1">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="39028" checksum="DA93D56BF3FBF162" modified="2019-07-31" version="1" fragment="single">MKFNQWCCFIQLFRKTLILNILVFINSSNERDIIFNLVKDNKESDFKLVIDETKPKCMCQYQRSSILEEKNEKKNQKIQNNTYIISNFEKNLFKFDKFGNLNDNNPSIEIFHCHHIKEADFLIFYDILISYYLQDDKMTNDRFYTVLYFLEYFRIKQNNKLRNVLKTILYSLAKSDDIKHFKVDKVSFHFSKQEYFSHELFKKISQEYFKILNFKTPSKLSLFIKEKEIYIPNQYKGLYTEDKKYILMINNVFYSFFKEYIAENQKKPNLFILLLNTLDIKYLHVHYVRKTNLKVCCFVLKNLKKPIQEILFYYSPIYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS99</accession>
    <name>A0A4Q9LS99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1206p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001206">
        <property type="protein sequence ID" value="TBU11438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1206p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="10523" checksum="33FCD0AD6E1D3A56" modified="2019-07-31" version="1" fragment="single">MSRTIISDVDSIASDSEDGEIGGDTSSDDSIIITHRRKRLRIESESSISSSEAEETPTFTNIPPTNVFSKATNNFFETPGPRCAPPPDASPVTYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD5</accession>
    <name>A0A4Q9LSD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1240p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001240">
        <property type="protein sequence ID" value="TBU11374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1240p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="248" mass="29312" checksum="68E8B5FD6D52988B" modified="2019-07-31" version="1" fragment="single">MITNESSTHYKTFKAKLLTLNGILSKILPLDVLNMHPFDYFTEYTLNISDILDSLIIKAQNDLKKYETQNLELKEEINEMKKYLEKGNLNECSSSIESKEESENIFIAQAFLQNEKQSLSFEVEKVKKEINFLLESVISLETELGRQPHFRDFELTVTENIFLTRDLYLENNFSFKEIKIYDCKNLLERKEIIKMKENYSNKSNINNKEINTFEMIKNINENNKETPVYTFPIKPSLSTIRFLKDRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG7</accession>
    <name>A0A4Q9LSG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1727p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001727">
        <property type="protein sequence ID" value="TBU10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LSG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1727p0010"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="321"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="816"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1377" mass="154021" checksum="D5249810B64276E8" modified="2019-07-31" version="1" fragment="single">MFLTTFWSPKCYIAVSLTSVSPNSRGDNNTDDNREDNSGYICGDISSDKNNDKYNTNNEKYDNEKYDNITNDNSNSKQNTNIKLTNNNNKHANTNIKPNIKQYTPTPEYIFFKNNLYKLFKSNFKNNIFTFSHNKTPFIVEFNKKDYKITKIKVETTHPFSFYTTHTPILSPLLLYHHPPNIFTFPHPSFTSLFLEHAVSPFFVFQMFCSILWCLDEYVYHSLLTMALLVIFEITLVFQRLRNLKEFQSMNHETFEVKAIKQVKCNEDGNMVDSNMLDNRDRDSISSKKNKNTSKKNTSKNSNKNTSKKNTSNNTSNTSNKNTNTTYVNTANIYPGDIIVIDNPCQVPADLLILKGTCVVDESMLTGESTPSTKLSISDSDRVSSSVVSSNSIDTKIDTNASDTNASDTKMDTKMDTNASDTNTNTNTNTNTNPNTNNHTTNTNINDSLCLRNHKKFVLFSGTKIIKCTSLTLYVLRTSFSTQQGKLIKKMTNTEIRHEKEPFFFILFLLFFAIISSIYNIYNSFNIKNNYKLFLETIIILTNVVPPELPLELSIAINNSIQSLILKGIFCLEAYRIPTAGKVDVICFDKTGTLTETGLRMCGIVVGGGDGSSDGGRDSGRDISRDMLDNKDIKDNKESNRDIKDNNTTLNTTLNTTLNNNTPSPINTTLITNNNTPSPINTNIAKVLATCHSVVDLEGTLIGDPLETTIISYFNMYLSKKGVIYNNILYKIIKKYDFCSELRRMTVIGENEEGNVYVGMKGAPEVVKCYLKEVPVWYDSVYEEYARLGYRIISIAYKDICGSGRVCGGRVCGGSGGKDISSKSSSSKSSKSNKDISRDKSSRDKSSSSRDSSSKSSRDKSNNTLITNTPTITPNNNINITLSNYNPFNDRSYLESDLNFCGFVLFESKIKEGSERAVENLIKGGMKVVMITGDNKMTACCVARKLGFYNGNVCDGEEIEEVLKNNNFLSFSVFSRADPKHKEGIIERYKKEGCVTLMCGDGTNDVGALKCADIGVALVECYSSGRDGSGGVGGGKDGVYKDGVSNREGGVSNREGGVSNNPTYTNTYTNTYTNTNNNPNNNSNTNNNPNNNPNTNPFVQGDERKVRLGDASCAAHFTAKTNSIGSVVDVIKQGRSTLVTTIQMYKILALNSLITAFGLSFLDSMGVRFGDVQMVISGVLIAFAFMFLTRSKSLEEISVERPVCNIFNFYVMGSVIFQVLVHILSFLVVMWESEKYEKVVYNEKFVPSLMNTSLFLISVYQQISTFIVNYIGRPFRESLSENFHLRNCLVGVSCVFVMLLFRVNEDFSRYMEVVRIEDSFRNFIFFVVCLDLFLCVLGEKGISSILLVRLVLMFYVVSTLCSITLCSMLLVLYVVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSU0</accession>
    <name>A0A4Q9LSU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1636p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001636">
        <property type="protein sequence ID" value="TBU10635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1636p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7628" checksum="11B3154F9B59E4BD" modified="2019-07-31" version="1">MDVEAYIQSIVLKKTVETIFFDRRRRIEVIDKNIRAESDLEMECIVVKDIVGNIQKNDNLCSRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ9</accession>
    <name>A0A4Q9LSZ9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1065p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001065">
        <property type="protein sequence ID" value="TBU11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1065p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22448" checksum="8AB5908499D374AB" modified="2019-07-31" version="1" fragment="single">LNFLNRLRLSNLSLFRISELLIDNSVLQCLSLNSNLTHLYIYNCPIKRNYFIDMPNYGSFFKKLVHFSFICCDITIQDTFALSHLTNCETLDFSFSRFISCSISNIFKKENTYKVKNLNLKYLFLLYEDSTAINRLKNLTFLNLSDCILYQNTLCTLKFNGLKNLQVLNLSGINIPRNIKKMLNEEFTILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT35</accession>
    <name>A0A4Q9LT35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1485p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001485">
        <property type="protein sequence ID" value="TBU10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1485p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020246659" evidence="1">
        <location>
            <begin position="18"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="424" mass="50490" checksum="2CB908CEAD1594B1" modified="2019-07-31" version="1">MFFIVLAVIYIICATNPKPTDDMLLNHFEQINNVILSSVQDAENEFIESLDQEVHRINIGSNNHRKEIIDGILETFPEKSMKVCFFIMLNSHSSYLEEYDAFLLHRINSGLILRSIKKDNLNSKENTKTILVINRKPFLNFVIKFISNMKNVLRNMGNNSINPILSSIGFLMKDHKNMTNHFLTGIYKTYYDRSQFHLDIILVTQRYKNIVFLDLEKIDEGLKRSINFYKIYRLDFEKIKDYFIELNLKTKYFFLNQIISTLGNEIDYYENEEPVFTQFEKSNVDFNAMKIYSKKVIDITGNSKMFDLENIYFCKIAMKKQNLHAFMPEKHFAHIKLFHFKIIIYTTKPEIFNIRFYTKKTPLQNIIFLLRVSSIFNQQKHNHPFLKIIIKINKMNRTQKVLNWKEFLLNIKDLLQYNGMNSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG2</accession>
    <name>A0A4Q9LTG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0985p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000985">
        <property type="protein sequence ID" value="TBU11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0985p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14669" checksum="E573436495FF6586" modified="2019-07-31" version="1">MMTWDGIVTKYHKSHPKRLEIPMNIEAYIQSIVLKKTVETISFDRRRGLESELNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGGTTLEEPTNNINEESDLEEAAAVVKEVEENIKKIVKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTI5</accession>
    <name>A0A4Q9LTI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1484p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001484">
        <property type="protein sequence ID" value="TBU10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTI5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1484p0030"/>
    <dbReference type="OrthoDB" id="2194544at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="15005" checksum="CC9C590E9415B0A8" modified="2019-07-31" version="1" fragment="single">MNKTNKDNFSKNNSLFYNNRGMVSRKTISLLETYFKLSCLPENYGILNSKPQRNNNDQINMVEFDLKIEGTEITMKEKIRKIKNIKKELSMEWIEHFEYMSETNGWGDKQMGLIAYKLIDDEDYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL0</accession>
    <name>A0A4Q9LTL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1015p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001015">
        <property type="protein sequence ID" value="TBU11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1015p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="361" mass="41505" checksum="500A6266095C504F" modified="2019-07-31" version="1">MQEKFVALHPNPVTHHPTDSHFSKNQGTILDQGEAKTCLRVESTHKKPYSSYKIDDGSNFGDNSSFSTPEGVSHKISKNNNAPCLVYSHFISIDSPPEKLSSLELKNLLNHISNYSENMAIPDISIILDIDVLFDDILKEGIFAKYFLLARNLLIIEKNIINIDAIKKKEFEDLFKKNGKNMDLAVPETSIFYNIPLLFHLHKLLEVEIYSCTPHVKYYVRIAFCLKLVKSILIKTSEMIADILDPSKSTYIENIYFDRNFHKNFRIYNNLTVIIKIFTIICVNKSEILQGYLELFSAARECYKAKLPNNSCSEKNVFTDKNIWYLFDVMFRYEYFDISEIQFCSCIINPISGASNPSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL2</accession>
    <name>A0A4Q9LTL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1467p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001467">
        <property type="protein sequence ID" value="TBU10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1467p0030"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6640" checksum="5FB043B18D468D14" modified="2019-07-31" version="1">MDTQIKEYHAEVQQLFSRSGPGGALTLCHLKLLDTGRIRVGDIITLLDCEREHKRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ2</accession>
    <name>A0A4Q9LTZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0896p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000896">
        <property type="protein sequence ID" value="TBU12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0896p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="671" mass="78052" checksum="9DFFC5CF38DD5B48" modified="2019-07-31" version="1">MIYYGDNIQNLEEPDVDASFEILADSENENSLLFQIPVDILIFEYSNSYVIRSMYFDNSNSSEINEIYLNIKDITKGNIDIHMFKECLNILCYGWNYGVSGLNNENFLDFIQLLSDLSFDIFFTSNTKELVFIEKNEIRKLYLDGMNSSEKIIIRTTPIALKFMYKDYSKDKKIILSKLVFSYEILGIRISSDDRYYTAYKNSDIADLFLKRNAGICDVKTFFFSVFYTHDFKKNERIKYIEFERIDLTYDSRILGFGFYYLETLILVKCKFNKYPKVLSNVSFYFPNLKILRIIGFRLTNRFFNNLNYLKIETLDISGSNYVGSNLKFCINLPKLLKEFRMDHSYPNYNILNSMILNDNLAVLSMRGVDFTCLKNFTSFRNGQKYFHCLDLSGCILDDSMLNFFSINIKSKILILEGFANMNHLQKILNQESLYASVKCLILSNDSLTLSIFDFLCKFKILEYLKISNLSINLLAPFVPDCRCKGYISEIDLSENKLSNFFLYFLCQFHQLKRLSLSMCNLETGFMEILCSTNLSTSLKNLNIAGKRMSELDIQQIALLKNLNILFVSFDDSVFSGSLRKYGALKSPNLEFLILVFTNVNCDIANFVIMLSSLKSLNFVKCKLNDDVLIINFNLYPPSLKSITFTKTFIPENERFFLDVLRNFGIQVIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU52</accession>
    <name>A0A4Q9LU52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0868p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000868">
        <property type="protein sequence ID" value="TBU12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0868p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="54506" checksum="508AB14C187B31BA" modified="2019-07-31" version="1" fragment="single">MIWNKLMFLPVCFSNLKEISEKIWRLYIQSMLNTTKLSFFFLYLLTIGFLRPLRCVRITLNFINEKYDESIATCHASSYNHIKFHNKIDSHVLELDMTHNNNKIFSEPDIAMSIDTNQKNIIIGDQNMKSDTSVESQNDSIDASSNEDLNNNMYYGGEGVEYQNNLEILKATNITDKESGSIDETTDKQPPSFSPNKSSLIFDYNDAYMIRSLCFDGLNNERLTEIHLNIKDITKSNIDIIMCRECLNILCYGWNYCIPGLNNENFLDFIWFFHDLSCYSESEALDIFYKNLLPFLFSYIADKSSLNVFNSQNFDFSNYRNIFLPFLPVVYDLIEVSFDLTTKELVFIEKKEFRKYNLFGLESTEEIIIRTTPKALNIMQEADASNIKYLVCKLVCSFQIYGIRISGDNIYHSEPKNAENTCNFLLEHPGIFEMKTDPFSAFGIKESKINKEIKHIELDRISVPNIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB0</accession>
    <name>A0A4Q9LUB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0841p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000841">
        <property type="protein sequence ID" value="TBU12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0841p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="621" mass="72815" checksum="BDD13ED77509580E" modified="2019-07-31" version="1" fragment="single">DKIMVSRKEDEFKRNIFDSKILETDSNDISKHECLENEVIQDDKIFETAYIHPSPLKNKNEFKPQISNHEEIAFENNEEIESNTSEVSTNTRVNEKEFGFGVYPFISLIFNVSILLVFIFPILKINNILESFIRSISTRILLSIFISNSIIYFVLRFLYFKIFKEENSYKNILKISSLCVKVGIFYFLEKIFMPYVLFGVFGWFKNVGKKETFFVYNLVLGHFMASTTNRVLLICTNISESNFYGFLFKSLDDCVLTLSYVKGVGRILSFMFFNCILCGIFGFILRFYFVDDYLSLIGILILLRMKKKHFFYAVKYLYRFFVYAFGNKYNLKKKNGKFNLLFQISVAALCYLVCFSGFIFVGSKGGGIIFKKCEKITIFFEESFLKNKNHNFLNLNSQKTKISNIPVNTSVNTSVNTSVNTSVNTSVNTSVHTSDNTSDNTSDNQVKSQKNYRLNNSMTKECNNKAERSSNKKPIVDQKITNEVLNNRYPDKEKNSLVFLFLGIYCFMWTISLIKLLIFYKGILHIIRKAYCFLSNVGTFICSYILLCLILCCLFDRIIMVSRVFVIWMIVYIFIYRFDFVKWWWMLAVFFDWYLFLSVFGILIILCLKKRDVKKILEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH5</accession>
    <name>A0A4Q9LUH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Large subunit of DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0811p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000811">
        <property type="protein sequence ID" value="TBU12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0811p0020"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="8">
        <location>
            <begin position="231"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="399" mass="47094" checksum="98C7751F150ACA1D" modified="2019-07-31" version="1">MKRIKNIETPFILNFYTSLNVKTLNFNDFNDFVTKRLKTLRRIESSLTDLRLLDIKDAMEDNLSHFLCRLVCSQAMWSLIWFVNHETKLFELKMQSLNDNQITDFFFNKFILYLKNLQINGEILQINKNSELSDQKMTEIRVPRNGKIYFSKIHDLIANRRVDIIKGYTDLTIDTIKSFMVNEFRNFLENKMNSLYLQMLREPDERFFHIFKLHFVQPNPVISEFSSLKENETFFPPCMFGIMKRLTSTKHLKYNDRQSLILFLKGIGMPVEKTIEFLRNSFNLDNEVFNKEYLYSIRHNYGLEGKRANYPPYTCSKMGSLCNNNSVGCPFLGDKTYVKDFLNIKNINLDLEDLIKSHPGQKACSKILNVLIEQEAEPLITSPVNFYNLFKNKNNKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI5</accession>
    <name>A0A4Q9LUI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1288p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001288">
        <property type="protein sequence ID" value="TBU11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1288p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="21127" checksum="93669D1423C53F0F" modified="2019-07-31" version="1">MIRKYIFLLIYLYRLLVVLISNTGLYLFYINYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKHKYTSTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQHANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGMCQHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ6</accession>
    <name>A0A4Q9LUJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0801p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000801">
        <property type="protein sequence ID" value="TBU12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LUJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0801p0010"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2178"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2145"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2178"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="2360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2360" mass="269820" checksum="16E72A79D0AC08D1" modified="2019-07-31" version="1" fragment="single">MLKEILQSNEDFKKKIENFETYVNTPQYLQEIYKSTDFTDTFLPFAIQVLEAHPPDKANTRTTQIRTTVLRTLFRTKPKDSLDTHQLYRLLSHTILHDTLHNSSLSIKCYVSILKKLRIPDDCTLDLLNCLYILITEIATNILSNTDTLIFSSFYTLSEAIPLLILLLKISKTPKDPLIKIIDILTQFYKIFVNDLPDTKIFLSNEHILIEVISLFSKILKLHSEILLISPKHDWSFKSIFPEVCIFQITFCPDDAIDLKKEIFHQISYLTTKFKDVFQQYIEIIISEDLMIKSSTPYLRVLGLTVLTDIAFHYKDRLSKEHIYKIANTATNFLDHELSVFFLPTYSLSNTFTIYPTTISNTTISNTTISYSFPNSFHLTPNQTNKEYEEVNQYFKSNNLDNIDNIGNIDNNTYNNQSTNQPTNNTNQYTKQPTNTYNTNNNTYNTNTLSVVDEDTFTTIKYIINTLYQINDIFFTLKHSSYEKTAFYIKNLHTLTRIFNITPYLLQQDISQTKIISRSSIKSIKNILHYLSYKEPYIFNSEENNSFSLLYRTGLFIYTKILEEKDILDEFCSIFLYLEEKVFLDIFNVNVYYLLTSTMFNNNLFCIWRFYLSVQNISAKVSYYLVSEMKYCLSCLDNKVFEGGDNDSREVGGSMDRGVSNSSKDYKDINRGVSNKDMSYKDINRGVSNRDSDRDSSYKDINRVVSTRDSDRDSSYKDINRGVSTSISDYKGVSNSSSNIKGVNNNTYEQHPFTTNTYEQHPFTTSTNQHPFTTNNIEQHPTNPSNTPLYNITPLPLFFLEAFKHIFKSLLIYPLDMEIYVIAYLHTILKTLITEDPHRMFYYKILKELFIYLGISFGRYNGVYRYLFTKLPDIIYALRDMMHKHYDQDIFIELILNVPISLSVLIPCIRDLAEPLCKGLRGNIDLQFRSLRTLELCLDNLNLEYVESITEGYMYEIVCILMEMMDRKETNSIAARILGKLKTFNRKFLESTQTYIHKSYNKGMFDIVCGMIGVSNGLEGVNDSSRVEGVNDSSRVEGVSDSSRLEGVNDTTYEQQGVSNTTYEQQGVSHPSHNQQGVSNNNTVNNNTINYNTINNNTINNNTSNNNTSKQDPFINSIYTNNTITPTSIITLPLDTALTHAIQYIIGISIKESFIGSVSDIHTFKNTIKIPFVSNTLLYNSYILIANFIYEAAGWSVLENGEVIEKACKHLRIIKKERFTNFLRNKYQSALNFTHLKRLKGISMESIINKKQIFYDSILSLFECSNFSFENNSYFILKRLATQVVVYKIIQRFKLFSLKTKIHFDYTPFIDALIESFGSTNKTLLIAQKILKRINTSIFKICETTLNCSKVDLYDEILKKLCSLCSYEHKKKRKAGINGLIYFIKNIDLGDVWLFSKRCDILSTLLFYVRLSDKECNSVRDLIFYILRRTFDSGGGGEGDICSVGGDVGYSSNNSNKDSSSSSNRDKDSSNKDNNPSNSSNNLSNNLSNNPSNSSNNTPHTTPHNNTPHNNIFTFHLLSNTYDKITYDKDITVLLLGGITSISNKVREISQSSLEYLSELKGLSVNELLEPYKDLIRNTIFKGESYFRNNNEQCAKLDSLSYILGLRPPLFIENVYPLYDIVITKLNRNISGMGVGMGGSVGVSMGVGVGVGVSMGVNVSGSVGVSNINSNISNNSSNISNSVNNLYTSNPYTNNTTSNPYTNTHTTTNPYTNNTTSNPYTNNTTSNPYTNNTTNTTSNPYTTSNTSNPYTNTHTTTNTTSNPYTNNTTSNPYTNNNTTPYNNTPTDSDVSIYSYKYLLSLITLSNNKENNKEILETIIILFYKGLYSNITDIIELCKQGLRQCLIHYNNLSKKLLLNLQKVFFSKFMVERLDIQSISFLINLLEIYDGHLDNDMLTEVVVSRVVEIFKVEEMGVWGVGVGMSVGGSISVGGVSGNSISGNIGSNIGSNIGSNSVSNIGSNISSNNSPYNTNPNTNTNTNTNTNTNTNTNTNTPHNNTPNNNTPNNNTTNTPNSFDLLYKGFELISILKFKVSFLEKNKHLLENIVKTFIILENNYKLLTNYRLLRLFKEIIERNVILSNLLFKHMNYYSTFRLFIYLYSNSSIMSKYFKENVNVFGEIFFVEVMQVGVGGSGGRDGGSVGSRDGGSRDGGNRLDIRDNIRDTNRLDIRDNTRDTNRLDIRDNTRDNRDNIRDNTRDTRDNTRDNTRDIRDNRDNTRDTTNTNKHLADKIPYSHTFIFLDILNYKFKENEIHYSAMLLRECVNRNKDTSILITFLRSKVGVMSVETINYLFEFDYSFILNDYSRVRDKNVNERLKSMTIEVIRRRLRMYCNMGRLGGVSDSINTLHLVNNKYSEQQGVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT8</accession>
    <name>A0A4Q9LUT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0761p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000761">
        <property type="protein sequence ID" value="TBU12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0761p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="15815" checksum="26F95D5183FFB29B" modified="2019-07-31" version="1" fragment="single">MYIRFEYGITKKRCPDIFKDKKIMFKEHDISFLPDILLYLKESDIIEIIAFNERKILTLNVKHSHRSPVSVNFITQNEIVLSKELLIKIIACYFLIFEDDEINFLEAFNYVDIVKHGYKILEKDLKRLNEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD2</accession>
    <name>A0A4Q9LVD2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0842p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000842">
        <property type="protein sequence ID" value="TBU12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0842p0010"/>
    <dbReference type="OrthoDB" id="6510183at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53714" checksum="E8C3727EA8846226" modified="2019-07-31" version="1" fragment="single">MRELNLNLSSVTNLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFEFLQGRFYRGLSERVKSEHVVSRDEIVSFWSTMWNKNDDTVTYEDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQADCFYCGLTYLIPKGIPRRGSDYRPITCMSNLLKLTTKCATKVVQIEGAKEQVLLNIALNKELLFVLCIDPLSRKLNEKYIKLTVQTDTESHSNNNFSFIDDLRLLAKDSSTLSAMTGEAKEFLEGIGLEINKEKSATNDTCCEDTATLIEAVSVYKYLGIIEESRGIPTRSSFEEIKCKKFIMQSINMRYLLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRAELGRGLHSVELRSEHMLLQLLDCLEKSKEISNRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI7</accession>
    <name>A0A4Q9LVI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0699p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000699">
        <property type="protein sequence ID" value="TBU12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0699p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="386" mass="44506" checksum="16EACFDDA76DABCC" modified="2019-07-31" version="1">MSVVLKLINRNMLTTNIISVPKEFTEQNMTDYLNKILRKNATYTYFRDANSPSISDLNMEDDCIIYYLENRDVSRSLDVNNVLSLCYSNDKKLVVCKSDGEIIVFDIESKNIKSYTFEYPIIFLGKENFVGNNTDLSKKINIYDTNSIQMNYKYDFEKETLNENNILSKLNVDYIVTINNIIITDKIKYSNKSLISCCFYKGNLLIIGCADGNILIISNLIKQYSIKGNICNVSILNESIVYCCVNGVAGMFKYNQDNENLDKLNSDEDIQVICNFDKKEINCNEILCGMCIHEGEIYVAGIKGFVFKVNFDENKLKKIKKYKNCDFIKSENGYIFCCAEDKIIFLDEKLSEKLVLNYNSVIRDICFSHDYIYFADKEGIFGNQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ5</accession>
    <name>A0A4Q9LVJ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongator complex protein 3</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_1027p0020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="EMBL" id="PITK01001027">
        <property type="protein sequence ID" value="TBU11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1027p0020"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="16">
        <location>
            <begin position="77"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="557" mass="63806" checksum="C9D100A5F6D24DD5" modified="2019-07-31" version="1">MADYLVACNEIANLLVKFHKENKKTNLSSLTTEISKKYGLSQQPRLTEILSCIPSHESQLISLLKAKPIRTASGVAVVAVMCKPHRCPHIALTGNVCIYCPGGPDSEFEYSTQSYTGYEPTSMRAIRHRYDPFQQARSRLLQLQSLGHSVDKVEYIIMGGTFMSLPDSYKNYFIMSLHDALSGHKSSSLKESIIFSQNSKIKCVGITIETRPDFCQRTHLSKMLEYGCTRIEIGIQSVYEDVAFNTNRGHTIKAVKDTLSLCKDTGYKIVAHMMPNLPDVDIYRDMAQFIEYFENPDFRSDGLKIYPTLVIKGTGLYELWRNKKYQNYSPDDLINFLVQIFDIVPPWTRIYRVQRDIPMPLVSSGVEKGNIREMVLARLKDYNMRCRDIRTREVGVKEVGIKNSRNIKIDFQKPSQQKTHVTLVRRDYVANNGWETFLSYENMENDSLIGMLRLRKLSTDTFRPEVVGKNIKHNFLNDNASMIRELHVYGSSIPVSHKDGTKYQHKGYGAKLLLEAERISKEEHLSSKIAIIAGVGIRKYYEKFGYFLEGPYMVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ8</accession>
    <name>A0A4Q9LVJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CSL zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0814p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000814">
        <property type="protein sequence ID" value="TBU12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0814p0010"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="63" mass="7555" checksum="BACC236082A121CF" modified="2019-07-31" version="1">MAENIFLDDIILQIENTEDFNFYDEIDIKQFEYDDETKLFSYPCPCGDKFEISIYDLLNNEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM7</accession>
    <name>A0A4Q9LVM7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0681p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000681">
        <property type="protein sequence ID" value="TBU12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0681p0020"/>
    <dbReference type="OrthoDB" id="10670831at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="66844" checksum="6DB735C7C7DD912B" modified="2019-07-31" version="1">MEFYKFLDELDHRKIILTLEKEKHSGAKALINTPYKGTMYISCLGEVKRMNAVQYLIGRMIQNNYELSSVESTNSRENSSDINDELFRAIMILLRKSDKDVLNYEDSGKNNVLHYCAVLGNYDMTKFVLESGVNISKNGMSLYAYSVCENKKTENLLKNWTKNREKAGKISEERIELEKDFSNYKKIKISSSDSLDSTLADKCESTNEQKSFQVNISEKGAKPEPGTNNFEQVRKTFDFSSVEDTFYLRGNIKSRTELDDGYKVVHLDTENALKKKIHENVTNEITIKRFPGKLFFYLQSINECLIGWENVDLVLVKINVNDKIFLTREFSPNKNILINQMFIIEIPKKQDVNIKLTVLIKERNNEKTKYSNLDAPTRKIAIGTQEIKTTQLINYHNKIQTNTIKLQKYSPGGIFEALSSLFSKELPTVSHIDTQMVILSEGEIIHVPFNVPTSFNELVSWFKRRNYTYAFWFKGYINIRGNKRNIATQLWKRRFIYWYGYSMIIYNVYSGSLIANLDLSKLKNVIFADNSDSFISTKYFKLVFDDGDVEIHIDKNDKFEETYKALYYLVDSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW9</accession>
    <name>A0A4Q9LVW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0765p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000765">
        <property type="protein sequence ID" value="TBU12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0765p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="964" mass="111257" checksum="B8961A026055266A" modified="2019-07-31" version="1">MKEEKVLTEDQLTFFKSKMGNTCLGMWSDIPLVKLLRVLFINECTLRITSLIFWIHTLSLSSVRCAAVDIPEDIVGDKCNIFYFNIINEYSDVNISEFLTQSNPRFALRTEGGTFEEKKDICSGTHVDSEDDFCSNKIPRSDHIPIVVKEYVIEGKYDIEFSTIEMMSNMMCNPLSSEGFARSCYRNIVHGISAEQFDILEKFMLRDYDVTMLDITKADFCPMWYFIDMLQIKPSLGTDWFFVKFFKKSVLLSEIYKEYFLERNPEWLSFFSGVDLEAKDENEILLWDKILEVSPCPKTEEDCDFPDEANDNRSEEVRRYGGNQVVNIDANFGRMFGLLFAAIIRSFYMHLSYSVSDKEFVLENFTDQCYSENMMEDCFRIENGIKLRIVTDVIQKLHAFCSFRMYKHILAIFLGSRLYNSLEVTNVNFEPSKEYRSPAYKKERINDTFNFDGPEPPSTHNTLRKVFISDSFKRIKELKLNMVALGELDPKRLYDLRHLEKLEILNPNCKEVQRCVTKVLRCNIRLNSVKLFQIKISLMFLLSISKITPEIIILKKCTLESEGGNNQLDTLRILPKDAKFIPVLKKFVLEGEKNYFFGLLEHISLYENLEFLSLINCFGGNITKDFMDKIALLKNLKVLRVTGNDLNMDINFEFLNNLVNLKEFRIANCDFSLSRLSILGDKQAIQNSLTRLALRGLKLEDIQYFKCISRFEHLESLDLRDCSCNFSTPFNSEEIYLPPSLKSINMDNIKFASPTIISIFNGLDKLESVSMKGFEFSKSDSMVRFLNSLNSVINADFSDCCFEGVGVFFFKSMNSLGCLRLFGAKFSSDLNVWKCLNCLPAPYNLRVLCLGNVVFDSPIVYSTPGANMVNISSLVDTESFLSKASKLDTVSLHLVAFGENSLSKPILERFHKLKQLYVGYDVIFNQSEQLNILKKEIPARILKIFKCSKTGADVLKRYNRWTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP2</accession>
    <name>A0A4Q9LWP2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0511p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000511">
        <property type="protein sequence ID" value="TBU13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0511p0020"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="912" mass="105511" checksum="A36189DFB83B36C8" modified="2019-07-31" version="1">MLFFSLYLAICLANTDDMIDSVDKISEYTDFNMMLAVQVLLPKTDSKDFVDRPTKKPLKEVVKAFRKIEKRLGIDKIKGHFDLYNFINKPYLSAYEHEPQTVKLLEDFLNQNFLPVGSDIEAHPATDYNESPRFLQNLTNKNLISVSKALNNTWKELSRKKVKNPQVHNSSLFDLPFPFMIPGGRFREFYYWDTYWILEGLLVCDMNKSAENIVRNFMHIIDKIGYIPNGTRKYYSYRSEPPYFGLMLLKLLDYENGIFNDLVLGDGLRMLEKEYEFWDKNRKIRIDIQLGSVSNDYNTIVKDYEYETATTKEVSNPENTATASAYKTSVYLNAYHVTADFPRPESMSEDLSTYKKQNVLNETQMYSNIKSGAESGWDFSTRWFGDSTDIATITAYDQIPVDLNALLYRNEVIMSKLFSRKGNEEKALYYYRKSIDRKSAMNLVLWNQNEGVWNDYNLKSKSFVNSRFYFSNVMPLVYGIEPVNGSNYDILKKYSKEIFGYKGGIPASGYGKGGQQWDFPNVWAPHQHMMVELLINMKEDAMAFHVAKSFFNSVYVGYKNDKAFFEKYNCLKVGFTGAGGEYAPQTGFGWTNGAMLSFILQYGDKIIEDYDHEKGYNDILVYLNKELTMRNVESAETSERNNLLNANNIEMINSDGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLYSKLCSARKNEHVSVSDSSRWLKKGNIRLRDEAVMCQHCGKSCITADHLATRCKKMLVVRCLHLLLLNRYKFKSSKRISSHSVQEILDNEYAEIRKLKKYDLLANELGLIYKCSVEIIPYVMTRDGIVTKYHKSHLKRLEIPMNIEAYIQSIVLKKTSGLNAEESWEKASMCEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW0</accession>
    <name>A0A4Q9LWW0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0800p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000800">
        <property type="protein sequence ID" value="TBU12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0800p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="42173" checksum="09AFFC7C01EEAC2B" modified="2019-07-31" version="1" fragment="single">MYFEKKFKKIYLLYSIFIVWISIYLYEISETIIYTRKIKSRINPFKEHRMVTECIKEDENVFYNVQNELSRYKIFYLNRFILTEIIMCLILTLFINDKFRNKIIAFVERNKIFEENRFFIRSLDLNCITLISFCVFLIDYIHLLNKYGIPDSFIDQAFYVKYLISPLLYIISYKIFNKFGRLPLYILIGFLLLFLQPKILIPLVLNMNRLLKGYEKFDINLFDDRIKRKLIEFNIEDNVYISKIPDSVKNMGVFKYFTRILVLIDGSKREYENNPKMLNSMFSHELGHVSRGYKDMIFISVCEWLLDILIIFLIDFFSFRSRKSSKLSRFTNFFIFCLVYFLILRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX03</accession>
    <name>A0A4Q9LX03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0478p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000478">
        <property type="protein sequence ID" value="TBU13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX03"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0478p0020"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="341" mass="39296" checksum="8F2B3F81B6C0C429" modified="2019-07-31" version="1">MSQIVQEIKDNEIKTDGKIRNNRASILFLDKKKNMITLIDVDITSQDILQIFENKKFSKYDLLANELGLIYKCSVEIILYVITWDYCDKITYVTPKKIINTVEAIFFDSIKGIKSRPNAKESCKNASMGITKKAEIPGKILPYMICDSNEEYGLDLEEDNEALHISNLKGGVRNKVVKRAARLLLEKHYSSLTYDFYINKRVVQEKTNIQSKRLRNKVAGYSTHLMSRMRKGVVKGIFIAKHEEERIQKENFIPKEKILDSEKVEVDDLTLNMINQYGFKGNFTPFVLINKSDFYFKKTVILYYGSINYHPLSTILLINTPLFSIIVIIPPLTTIISITPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX13</accession>
    <name>A0A4Q9LX13_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0603p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000603">
        <property type="protein sequence ID" value="TBU12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX13"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0603p0020"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="295" mass="34679" checksum="169B56ADA74E3188" modified="2019-07-31" version="1">MYHSFKRNTNISKYFQQQKTVNFGIPSLDNLINGNIQEGSLILIKEDKDSKLHLFIQNIFIAECISNEYEVSIFSRDVEFPCIPDKITENELINEKEEKMVFAWRYNHLNPPITKMKYDLTKKMNLNDKKKFKIFYDTKLLTSTILENIKNVNRNSVISIYSFLSPLWFHFDKISDEEIYKFLFSLRKTIKETKSVCLVSIPSFFKENIHFNLYFDIIFNLKSFLFTNICPNYSCILNIEKMVPPFGLKENDLDSLKYGILIKRNNMVVEKVVLPPEDIVGVETTSCSTNITNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX81</accession>
    <name>A0A4Q9LX81_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0795p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000795">
        <property type="protein sequence ID" value="TBU12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX81"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0795p0030"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="301"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="44842" checksum="CFABC9046E23A228" modified="2019-07-31" version="1">MHDQIKEEIEKSEENLNICKKNKKEKSFDISSDEMDSLEKLKKDMEVIGNKNNINSTSNDEESNKEYCEESNKEYCEEFNEESNKEYCEESNKEYCEEFNKESNKEYSDCKIENNNEFKDISFDKQRIKNTDEIFDESKIKNNLSKITETKIDSIETENKKEEIFSSLENIKNNQIQTEISFFKKSETKKTKNKSKLNINKEMLDNQTETTIKEKRSKKRIESEKEDKIFKKTKKNEISEEEINNFVNKFKKEMLNAVNKDNQSNKEKKPSFEKVNMVDSVSKALLNKKYQTSFLDSDVLSVIRMWLEPLPDKTLPGYKIKSTLLELLLVVPVKKYHLIESKVGRIVFFYSKNERENKEIKRMAKKLVYLWTQVALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE3</accession>
    <name>A0A4Q9LXE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0721p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000721">
        <property type="protein sequence ID" value="TBU12531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0721p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="571" mass="68270" checksum="5FD4FB92896C994A" modified="2019-07-31" version="1">MNFFIFICKIIYASEFEYTLNSEDSLSIHDNYLEISYEFKADDQVKKCFDKLEFEIEDERKEKLVKITSFYYKKIQEYTNNESDTFLAYFTTWICYFVYNPDSEIDIQKYNPEFLFNLIRFKKFFEFCKEDKNMKSNIKDILVKLTTYRLQGKNCNYNEWWKQNYDSLKEKYPEICTNIENSSNRDNKIDIAVLENLVLCLNSHEYSSCIFSRSLINATHEYQFGFFLCLKCMFLLGKKNEYFTLKSLTEKEIINPIEISAFTLDATSYIDESFKNIDFESYKKITKYISEPIFRKILKVNEDGFEKIYEFSGKNDLSNIEAGDSNSSLEFIEYIVERKEINYINALYVFLKNISKTEYHEYISAVLCLKAFCFKEILTCKQTMIRSIVEILFLADVLKMEFENENKNASAINTYRVHFIAVIKNYLDEQRIEYDKNLVLNTFNHFLLPRTSSILKTFIYVELFTNSIWRDDYNIRLEKYCNENQQEFDEKLLVNEENIFFDVFRQEFSRLSPEERKKIFTIPVTKAQTSDNKNESKEFGIIDFLLFVLIPIVFIGGVILGVYWYIYKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY88</accession>
    <name>A0A4Q9LY88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0658p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000658">
        <property type="protein sequence ID" value="TBU12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0658p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1050" mass="125600" checksum="94B6D470456519F0" modified="2019-07-31" version="1" fragment="single">MHNFQTNNQQLKDFISNILSKNLSKESILNQLKSEMFLNISKVSLCRWSKLLIWFEDELKKYSFEFFRNKIQHKAFDRFFFEINYNDDTNIGILDEVKTILDGFSKKQSKPNIFKILEDTSNLSLQISKIIKYEFYKEYYFQRLLSNDILVFNIFMKISPIKNINVIKAGLLFFTYDDSNEVFIETLCQIFSKFPFLSHKFTFFLEDLKDCHFLRDLTLDHSIISNTGLVQKQKFVYGILNLFKSFLYSDTAEVMHKKIHDKRNSKTFNINEIYQVLFLIHHKSENLTSFIITLENCHLKCFVESIIELLEVHLKRKKTCFIFYQSLEILDIFDITLFNNFRLLTSIIGIYFDSNKLDSALKVVDSLIVVFIFIVENETSFEQNLIDLLISTLLDVFIKYFAKITEAQYKIINNKITTLYFIKEISVSIFRLKNIEKYFKALRHFYKNNVVKKIHEFLESKDTIAIDYFFYQEFHIKQLLIFLNNILSKTNVHLYIDNHPLIENLIKFPEKLYFSENKLLIWDLAKHIICKVSYNSDNALFLKRLLLFVTDALNQHSLNKTSYSESNYIKLYEKLCLVVNFLSYINENIDIFYKISCMNIRKNIFRCNEFDQAAIFDRIFNLESKNIFKQNFHKVFYSNSDILTGFYEICYISLMGCILRFNLTNTLNEFKLYEVNCLFIISFGQNKLAFYLFNLSKKYFFIFASKYICDKLQPFERLCNKELLNCTQNNLQIKYVFDKIFLILEYFMISIDSLGDFSDGYKLLEFILNFLEKNLHTWAYESLINFFKNTISEFFHLMKILNNLEIFSRILDLIAQLDLNSVNPLKSSSIFLFVSNELNSYKPLERVFDFKSSEDKRISFYRIIASNINLNIDMNKKFAYNKEILFSFIEIYDSFDDEKIFSYLICLIRLSEYSGLFTKKEIYKNFGFKNALHFLSKDRRNIFSSQSILIEYAYLYLYCLFEDESILNYFDLKLVYKDDLRSPENRLLKNEEIYVKKYIFYDLLILLQSSKSFQETIITLKFLTESFYNFPLILNLIDLKILLDLFYKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYC1</accession>
    <name>A0A4Q9LYC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0319p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000319">
        <property type="protein sequence ID" value="TBU14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0319p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="20938" checksum="013E193A7C76E12D" modified="2019-07-31" version="1">MLVSDYQKNPRVFEKNIKSIYFCKIQITMKRVKDLIIFWENTAKPMNDQSSNVNTSKALDNHCKHNYTKPLNIYNNIALIFAKTSLPFKDNVDNYFHKKKEAPVYITMAQVYVASKNILKDGIKNDGVNFLNNSSANLNNESIIRQIEEEKITVKKIKRKKRWEGISDSKERLKNLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYD1</accession>
    <name>A0A4Q9LYD1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0581p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000581">
        <property type="protein sequence ID" value="TBU12931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0581p0010"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="73"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="30137" checksum="34A154136EF1E4DB" modified="2019-07-31" version="1">MEDNDSIHDINNSKQIIRKNSERIEFVNDNGKVTFSDVNIRLVSKTEAENNLREYFKSVRSCWNVWNECFKFLYLNNKKFDESQGVILEIFNYLLQNGLLKSIGLFRKACLIEQMKIVVENIKQGKVFDFRKFTEFELCNGIKYFIRVEMDGILGLRIYENLLNADSFCIERNPRLLLICIASMMKENISFFFLSILRILGCVARYDTNRMDSKALSIIFCPVLIGETILKKMSVEHIRKFSHIFESFIEIFDVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB2</accession>
    <name>A0A4Q9LZB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0480p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000480">
        <property type="protein sequence ID" value="TBU13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0480p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="27429" checksum="C19275A81971289E" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNEEIKAVNNSEISLKETKTYDRDEVTISETLPPQPTIHNNTHSPSSTTLYFTAVSLLDSAPPSSCPDSSACGPANTMESLNAPAMSEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKFGRTVDIDVLKKLTHNEAEREIRQEENGERRRIATCLAEPCSLTDTTLYMNLREKFLCKIKELSEKEIGDVVVRTRKLPSELVDSKVLELIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG6</accession>
    <name>A0A4Q9LZG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0515p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000515">
        <property type="protein sequence ID" value="TBU13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0515p0050"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="27544" checksum="15FE0BCB7F70D0B7" modified="2019-07-31" version="1">MSNILDFGPIYTSTGTILQINYAQKCADNGSTCIAIKTKQGIVLAVEKPITSPLYTNKENSRIKKFTDTCYTTYSGLLTDGFCIYNLVKKECYSYIEDVEKDISPAMVKKLLSSYLSFFTVYMGCRPSGCNFITVIVYNNEPFILGSQSSSLTSYYKAHAIGKGSARCKTELEKLDFQNMSVSQMIEHAVRIMYKSYDPLKDKEFDIEIIYAEEKDKYTFKEVDGNTLSEIVEKYKNLSVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ7</accession>
    <name>A0A4Q9LZZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0207p0050</name>
        <name evidence="4" type="ORF">CWI38_0173p0030</name>
        <name evidence="3" type="ORF">CWI38_0178p0050</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000207">
        <property type="protein sequence ID" value="TBU03943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000178">
        <property type="protein sequence ID" value="TBU19899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000173">
        <property type="protein sequence ID" value="TBU19921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0207p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0173p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0178p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033831993" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="107" mass="12691" checksum="884E0BB0F1FCC1E9" modified="2019-07-31" version="1">MNILFVSFLSRLVKLTGINSFSSNINRDNCYRKFCHLVIDEMLAKRGKYRDENLEELESSIKIIPINKKDELCFKIKENTKAGRKMMKCCKEIENRSPNVWIKEIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I8</accession>
    <name>A0A4Q9M0I8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0387p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000387">
        <property type="protein sequence ID" value="TBU13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0I8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0387p0010"/>
    <dbReference type="OrthoDB" id="2192425at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="775" mass="88952" checksum="F4F19D73DEFF0042" modified="2019-07-31" version="1">MNISSENKDLFQKIYEIQNFSCGDCENKIKNILKSTKGIKNTYFNIFLRQIKIIFDRNDISEKQILKKLKDNGYIVLRNKRFWSTIFYIVTLLYVPQLFSHFFLRKDKKILFIEFILALFIQLIVFTNISLINIRKNISVENLVFLGSFLSFAYAIIFIAIDYTNIKEISSMLETSSMICFFILFGKFFRENIESEVNNFVQKLPVSHYKFYETDLQKFLPIDEIKVGDIIRIENKMTLPIDGIITNGVTHIDESNLTGESFPKKKEPGMIVYCGTTVIGKGILVRVTKKGKNTFLSEILQLIKNSQFDEKYSLIRKNRIVNIFIRSVLGISLICFLIYLILGILNIKPKILYKTNNSYVIFVAMKVALNVLIVACPCSLTVSAPIALSIATQFLCKKGIIIKNIESILKVNSIKKIFFDKTGTLTYGNINVTNYCIFKNISEEIVLNILSKIEKDSLHPIGKALYSFTKETFDRRKSKLYKNIFYNRNETQNYENSTDKSTNNNYSSNYLKKYDFLNQEDIQINKTIYISGNGIKSTIIHGNKKFVVKLGKKDFVSDYSDKEANKFEYKKYLNEEKINLEIFMSFNNEIIAFFILDDQIKSEAIAVIQRLNDLNIQSIILSGDTLENTHKVAKTLGIPTFYSNLTSKSKLELISVFKTPFTSVCMVGDGINDSAALKISDIGISINNTLNITDVYINSDNLLKILDFILFSKKVTKRINANYIINIVYNITILPISVGLLIPFNIYLSSRISCLSMFISSLCIIISSYSLKNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J7</accession>
    <name>A0A4Q9M0J7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LSM1</name>
        <name evidence="6" type="ORF">CWI38_0399p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000399">
        <property type="protein sequence ID" value="TBU13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0J7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0399p0010"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="12243" checksum="0A8E6283D582E2A0" modified="2019-07-31" version="1">MNNNENVLGTTDFEEFLDKEIVIMLWDGRQIYGILRSFDQYNSITIQNTREIYIHEKLYSEKDIGLVIVRGENIILLGTYKGFLNNFNKMDYLKFCEMTSAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P0</accession>
    <name>A0A4Q9M0P0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0239p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000239">
        <property type="protein sequence ID" value="TBU18507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0239p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="54092" checksum="65B6F71A26D7E203" modified="2019-07-31" version="1">MINELDLAINHNLEYFCLKNMDIDDENFGYFLQKWKLKGLVLDNVETNNSFIGAYLTTNKTLEYIEFKNVEMSFSWWSCFAKKQNTYKVIFSYNSNFEADNFIQEFMKLDSPVVVSHLEINFHRYKICKKFGRILQYFPYLKILNLSFYQSEIDFDKNLLEAIQKMGNLESFSIDIDRLNCDFFKYMFQNKKIEFLHFNNSYSHRQSLDLDSINNYKVLSELYLNILHISENTLREICKCENLELLEVKDCYIGSIAGLRPIEFKSKNLKILHLDISNLKIFSDLDILSEVNCLEGLSIFGSKSYFCGLAYLNKNWDLKLRTFSYRNGILQINDLNRIKQFMVIEKLDLYKCKFVDSGFCKLGEDCKFLVSLKCLNLEYVKLNSNDIQYLKRFINLKILSIHFSEYHKIRADFISIPLKRFHFSSKKMFEKTNIKNLLRFLREENIIFDIINIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M150</accession>
    <name>A0A4Q9M150_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0075p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000075">
        <property type="protein sequence ID" value="TBU20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0075p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="779"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1280" mass="149751" checksum="E018D2E73AF0E7E2" modified="2019-07-31" version="1">MKIENDCFHEACSSMKNIVIYNSDHSNLILSIENYKNIDYVISAYKRYSNKILLQSKIKSNLLPKIIEILNNQRSNQNIQTSNHIYEKIIFELNKIVQNYKIEIFYSFVDTFTNQVFDKIFIELENSQIDIKNRFLKRKAGEINYLIEYPASAFKTDKDREIYIDGYIKNLTNVKSKKYLFITSYLAFILREILFIIISLCKNYGEVEMFLRSKNSKHLVLKNVEEIQITENWLNKLNDFEKVKTSILYKRLDLKFCENLENSQINKFLGFLYEFKELQMYTNEILEMNLGSFFVIKNETLTEKILQMFEIFIEKNLISEIEGFRNKISNIYIIIEDHKIFENFIDCIIKFTINIAKDYSIQKMIKIVENIEFYKNEMNKEYTELKTRILSQITIFRDYLIIIKASYNIIIILESANQLYFLEKLKAFQKNSICPERSSDECPQTNDGNNTAMKFIELCFNLCHKIIEEYFHNELKCKSGYKSGIVISTKNCARIIQAAQVCYDEETRKEKPRSAWKENIECKISKLVLSKDLLENARKQEKLSTSETKRFNLDLSKINDLSEALVKKNEDLNVYEKKITMYERRRKFRKENRMFELFRGRFYRELSGRVESEHVVHRDEISEFWSTMLNKNDKVVTYDEYLIPFFIDIINWLPNWKAAGIDGIYNFYIKKLTSLHKYRYDIVTVICLEGTPQADWYYCGLTYLIPKGTPKTGSDYRPITCMSNLNKLTTKCVTQVVQVEALLNVAINKEYGNNLKATWIDKIDISIGPEKIISKKIDRGILQRDSLSPLLFVLCMDPLSRKLTEKCTKVTIKTDAESHATNHLLFIDDLKLLAEDGQTLEDMTEEVKKFRNNIGLKINTEKSATNDQCCVYKYLGILEASRGIPTSKSFEEVQTKLIARIERLCRTTLNARNLFQAINKHAISLLNYHIGLDDAVRAVLSKSEHMLLQLLDCLEKHKDTSTRRAAILKVENINKTHLSLIKNLLKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSAKNNQLVSVNDPSGWLKKGSVRPHNKAVYVQHCNQSRKTVDHLVTRCEKMLGHDYSRRHNEVVRCIHLLLLNKYKSHSVQEILDNEYAEIKVTTRIKTEVKIRCNRPDIFILDMRQNRITLIEVGITSQDSLKIVETEKLRKYDLLANELGLIYKCSVEKIPYVMTWDGIVYIQSIVLKKTSGPNAQESWERASLSVILGAEMHKQPILSLKTVDNEEDDVKTENTKHFLLLILDGITTAKEPSTNINKELELEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M2</accession>
    <name>A0A4Q9M1M2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0275p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000275">
        <property type="protein sequence ID" value="TBU17648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0275p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020365246" evidence="2">
        <location>
            <begin position="23"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="463" mass="52907" checksum="0E51AC77517B8129" modified="2019-07-31" version="1">MKRIYFILKVLSFYSGVTLLAANAQVEHGSIIKFIQNESNASEKKKICVEKKAVIETKNVFNFFLNENDVLQMESNDFNQLLNADSENDREKLDESDDFNLNLSEHFDLDLSSYDKDLSKVNEFLESDDKPSINCITTHSVQSNNYLSEKETADSNLDEITIAHPEIDNNFLHSGDLFHAEIYEAVSYCDTALSGTNYFGEVINKSVEEPMSNVIHDFKVGIFDAFIPIDGTDDNTFASHDSDSDLPEIWLNSNQSTGNIYLENAEHNELRSFGKFDNKFDDSIINSNCFPLSVQIEDAAAFDLNSNNSYYSQQDIFESTFFSPLYETQNLSGVQIETEQTLKISEESKKENSQEHEEASITDNELHRVINFDNHIVDRENPKQNYASCEQAILGYKRVNPDIECLPYELDDVLIPNNKKTYPDKQTNFHVEKSLLKEKTCVVQNLQNHLGKESIPTKEYFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M6</accession>
    <name>A0A4Q9M1M6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0245p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000245">
        <property type="protein sequence ID" value="TBU18340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0245p0030"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6624" checksum="CB5CE28C919EA4F8" modified="2019-07-31" version="1" fragment="single">MEIKEGREGNRILPVIFKLATTNNSSKGFYTKNWCKKIEYERLKSLEKGKNILKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P1</accession>
    <name>A0A4Q9M1P1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0270p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000270">
        <property type="protein sequence ID" value="TBU17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1P1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0270p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="88484" checksum="EEF764FA540EFF45" modified="2019-07-31" version="1">MKYYHFCSLFLELISEGICTARTVTFFFSKTDSEFTGETLFVEELRLSNEEKELFEKLRPYRAIANKLKRTTDIPLLTTNTQNNSIRIIYPGNIKFKIGRIENIIDSKKLAFYVGHLITKEVFEFFIEIICDLTDINFYLPGFLYIQLMNCILCLIPETNIYFRKLLSRLNYWAFTGKYLNEIIKNQYCLIFTDAFTQRYFYITALISYLNFINISVTFDNSKIILTTMNIHNHDVYPPEEGLHQELSLTFENRSLNIFFASINENNNMQLYDWIFNGIKTIETIIFNHCNFSNLININESINCLIYKDFMFLKLKNCLNVKNYISNINEFRINKLRNMKLQNIQLSSLDLISFIEFKKIAKIKLENCTCDDDEIYTEKTLVILIIEIKNMEMNKLIHSFLKKTQFKILELKNVCLIYPYSLANISPLEDNKFSGKIKLEAVKTNENFFELLNNFKYLLLMEMKSVKNLSFRIKKNVNLNFLKLEELALKDFSLPKKIHNIQFLPNLEFLTLYRIQNISSLFYNLNEQQFYDTLRTLKIKGTPLTHLEIEKILNFSRLENLKLHTCNLDSSHLLNLNKLISKKILRRLILTNNKIKNIPITCKGMFNDLEHIVLDRCGLYAGSVSLFFNDTKSNKISFLDLSHNSLNRTDLIVVSGLIKLQVLKLNGINLQEDARLNNLTTHGLTKHLKFLEIKELTISAKDILFLSKFKVLEKISLSESSFKCLKITKVRICCSNFDVDSVLEIETLSNKEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T5</accession>
    <name>A0A4Q9M1T5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0233p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000233">
        <property type="protein sequence ID" value="TBU18636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0233p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020466579" evidence="1">
        <location>
            <begin position="16"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="386" mass="44639" checksum="D01CAB0847168139" modified="2019-07-31" version="1">MYLIVFLYLQLYLLADSTCESNICFYDIDICGHQASSEKRSSMSAFETNRSRKAKTEALKRLCVRGDGYNSSKKSKKFRERQQNSDSVCNPGILVSSQIVSSSTDKETTQLVENNRLNSTDLEIPASKTTSFPELERQKAKTKLRKLFSYLLKDNKKKIFKKKRKPYVRIELNSKQKEIVNQNFSNACDEIKKYITDNILTQKDEILDPTDFEYFEKKEKEILNLRIPKTNRILFISTDGIYSIWKSKILEIFNNAPLFLYSILPEILSIKNLVKEDSKSIKPQGGNYLVTLLIFEAIVGNPSLNNEKINMKNQKIEGFTDLTMCSQSLRGISAYLRMLLEDIERMMEILKELKNTYLPAESDLSLLHSVEKESMEQLRRRNNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2A4</accession>
    <name>A0A4Q9M2A4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0013p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000013">
        <property type="protein sequence ID" value="TBU20880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2A4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0013p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="53423" checksum="1A7A4D748BBF6216" modified="2019-07-31" version="1" fragment="single">MNFIDFVFKFFPVRFFQFSELNCRRNFKPVICTSIIILTIRLCSCSNRVTFLLKTPFIGEKIEYNINDKSFCFGYKTENHILICPGNHIIVNNCIICTKFDNNASHILLKKYIITYPDDFPLISKFIEQSIEETDGDDVVISLEYYYFDDFLYILNILKNPDNIIGSIEVMNIAFILKFLMKFEIKYCKYLNSFLKSLSVYLFLHYMSSDKPSRTDFSIIINGERNTGSIVIFIQKFLNLFYVNFERLNYFFSKKNSYFPDLKKGTMENFFSEKSRIMISPLNIAIFKYFLEEKILYNFLNLLFNAIKVRKLSFNCLTTKLNWNQTKFTNLIPFSCIEIEISMYYLDNSFIKYIYPLLSRFTTKKFKISVTEICLKTFEIIKILHNLQILCISYDSNTQSDRILKNIFQLPSYMPTTHISLTLSDSVLKDLYSFPSLLDNIKLRTFSFHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E0</accession>
    <name>A0A4Q9M2E0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sugar phosphate/phosphate translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0949p0010</name>
        <name evidence="8" type="ORF">CWI38_0214p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000949">
        <property type="protein sequence ID" value="TBU00618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0949p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0040"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU00618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="205" mass="23155" checksum="1EDA2CDEF093DCFC" modified="2019-07-31" version="1">MVKSSAPVFVLLSGFVFGVEEPSIKTFLTIFTIGSGIFLTTLTNTSFDKYGFFLISFASFMAGFRWAFVQFLIEKKKLQKNNILNTIRDLCLPICLLLLSLSLIFEGYTNIFTSEFFNTPNAIKKNVMVILGSGVLSFCLLCSEFLLVSYTSVVFLSVSGIFKELVIVFYSVCRKEVTMSRINYGGLFVSMVGMLMYNYCRKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M0</accession>
    <name>A0A4Q9M2M0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0072p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17042" checksum="1B0ED0CCD9F50CE9" modified="2019-07-31" version="1">MKENSKLNTAGNNEVVSCSAISRIKLYCGNQKKIEDHSATRLRINSQDSLQIVETERLRKYDLLANELGLIYKCTVEIIAYVMTWDGVVTKYHKSHLKRLEIPMNVEAYIQYIVLKKTVETISFDRRRGLESGQNAEESCDRASLGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N4</accession>
    <name>A0A4Q9M2N4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat stress transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0245p0040</name>
        <name evidence="10" type="ORF">CWI38_0099p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000245">
        <property type="protein sequence ID" value="TBU03722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2N4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0245p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0030"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="192"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU03722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="321" mass="37203" checksum="DD730E57C7F0727E" modified="2019-07-31" version="1">MFGDKKNYYKFKSDSVPSMHKPIAEFVDKLYNMVQDNLNEPYIRWNSDGKSFIIIHPPEFARCILENYFKHANLSSFVRQLNKYHFHKIKSSENIIEAFGSQVWEFRNPDFQKNRPDLLTRIKRKRSSNERSFRSYYDTGSNIVDQTSMMQDQILGTLKVITRYFQVIIEDLNEIKKFILHEKGLQPTIFANILLAEDNVTCSTYASVILKKIGCAVTIAESEDDIMEKLSGDKFDMVIFSLGLPNINSVVRSLRQYDNSTIIIAISEGLSKEECVSFLSLGINEILIKPYHHDALVQLINNYCNPKRRTGAVWKQYGISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N8</accession>
    <name>A0A4Q9M2N8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0001p0210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0210"/>
    <dbReference type="OrthoDB" id="2193164at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="39592" checksum="AC52D36FDA02A398" modified="2019-07-31" version="1">MIQCEISVSKNNIAGFISSSEIKLNKKKFSSEESIKLQIIKFQILGKFTVGEDITIFLQSIPLPILVNDIIKLPITYNIEFILPENSPPSIYTTCFSVTYEISIEILDFSNISYIFRNCFAVSTQKIINLEFFFSNLLIVPHNMIRIVGKGSSTIAKAIKNLRYLEFADEDKDIKDIIDKIKQLNFIETIKNDYINSLNKFDNDLVLLQQYTIQPDISRDKKRFFVTKNDNKICEIEINKLHFKDDYIKFKINYIVNIKITKIEIYRNILSSIGNNIHEKIEDDTIYSDSCLYCEWKGAIDHKYIFDIKCYDFVVSHFISFEFDSFKIQIPMVILKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T4</accession>
    <name>A0A4Q9M2T4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0061p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020683341" description="Lipoprotein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18995" checksum="CCAD1A3612EA24D0" modified="2019-07-31" version="1">MKLSVIKKTLTFLCLLQSSGCSTGYVKDTMLSNSDNDKEVNYSQPGSSSSQSLEDYSEDISGNGSGEKEYLRDATSYYQTCFLRNPREEKTFREKFSELRICGTSESSQDIRLETLDAEKNPDLSPKKESSDSSTNIYFFPASLNDYDNLFRDQFLISEYWIDDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3D0</accession>
    <name>A0A4Q9M3D0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0111p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3D0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="799" mass="94869" checksum="F1F071DEF1F1C93D" modified="2019-07-31" version="1">MPQYIYFKNAKSLNSEKTYCNSFVFLIYFPCWVYATTVSFFVFNNENSIKNVNTGSSSSYIIELQPKPTDWFIEEDKISLFKNNILCFKSGEETKYYNPTILTIPCPNKILLNPIFSKTSFESKQTNIKIFLKDVSYSALLLFLKLIDHPDIIINQIKIQEFIDILMIISVLDIEKSKERNIFLKELFRNFMFAMENGNEYFNFEKYCESYHYKHIKKSVLMDLLILYFDLITFNDKSAERYIVLSGKKLGFNCDTKYFTSYNLFKKAIKDEINLCLDEISLQILFRMMNIKHLMNIWKFIVNIIRLDLLYLIFSNEEICNKAILLFSYKIFQTEKLYIRYNKNLSNFLFKQTKINIFWENLKVIKLESNFTIEELNKVLGLCGYIQKLTLMIEPLNFEKLSLLVDFTVKNPDKICKAIKSNYDYINSEHNSLLLIPNNLLCFVKIIEDGSSNTVTPQFLHRHEYNYTHIEDTKFATNFLLFECSKIRSLKLRFQNNSVPFKFRKLDFTSLRYFKSIKYFLVQNIVICNELLMYVLESNTMVLLKIVGFVCAYNGKCFEKNNIINTKLQSLCLINPLDFIDTSLLIYLRNFKSVADLKFENVFVESSPSYSKRIYQYIFGSKEKIDKKIEEKINLKRLEIIDVLVVDNSNILYLLSKTYDFSALIKLTYRVNILIETEYFFFSNMERLEVITIDVRNPNEYINLKRLFNNRNLFSTVAMLYVYVSKIQKEDIEFFKSFRNLTFLCLSCAQMDQEIVSKLKKNDFFHVKLKIILPIQNKQLQEIKNYMETEFGIYSLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3I8</accession>
    <name>A0A4Q9M3I8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0047p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3I8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3I8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0010"/>
    <dbReference type="OrthoDB" id="2191622at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="101"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="420" mass="49592" checksum="9208463A79F670E5" modified="2019-07-31" version="1" fragment="single">DNFISEKQSVTILGTIWYLNQFVIKFYENLNQENKIFSLEESFYEEKDDNSEDKSSSISCETTIIRSNDYGNFRSGIRRRKTITIDEESEGYSVFGKKPDYVSDVLKENKLEDKILNENILEEMEGELNVLIKICTYVFYKVSEKEQFEETYREFLGNRLLGKKFVNLQIEDKIIKGFKSLIHKHYTHKMEVMVTDFKNRKTFLNSEILEMKMCRWPEYENCDTVWPSELLKLEEKYTKKVNKEFPRVKFTWMNCLSSCIVAINNFEIGMSVIQYLILKKISEKKRISKLELENQISIEFFDQNFCKMCDANVILEENNEYFVNFNISTNLNIIPTNFKIKMTENESPDENEFETQKLKTRLNSIIMSKMKSQKILQKNELINQCSETLGCSNEQCEETIEILISKGYLGLDGNILNYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3R3</accession>
    <name>A0A4Q9M3R3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0084p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3R3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0060"/>
    <dbReference type="OrthoDB" id="2188144at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22582" checksum="FB2164D88A838309" modified="2019-07-31" version="1">MKLFFLFFFEYCFCWRNYIIIDPKTTETFYEQVKSDDLQLTIDMSLISKGTLNYRVRRPNMVLADKDFKTATRGSAILKYSGAGPYAIDIFNPDDEPIYMVLGSYVDKEFEVDEDTAYIKSILEKLKSDLRNIYNQNMRIKEIKEENLRNLKKAKFKAYFLFVIALLYILVAYIKLRVVKSFFVLKKGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3U2</accession>
    <name>A0A4Q9M3U2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative subtilisin-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0077p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3U2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3U2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0020"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020457483" evidence="7">
        <location>
            <begin position="19"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="240"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="534" mass="60436" checksum="16D6655294A55A83" modified="2019-07-31" version="1">MILLFFLQILIEIYEIQARNFSSNIDIKSSIHDQDLDVHKPIIKEIRVEPLINDYKIDYDDNIQSLDKIINEKLVTTLPENSKEVCNLNTENKENSTEESILNTENCTDDFGDSIEKCYIVKTKSSDITKNQELISFLKSNNIKPTKTYSKLFGGFTFCTKNPNLSKKIKSLSIVSEIEPDLEYKINSVQSKIPFYMFLMNNLDNTIFKNYIINNRLFDLLGINTIFNYLFGSYTYNFTGKNIEIYVLDTTVDINDNEIKGRVSNLFKNDLCNTHGTNVVRVIGGKNMGFAKDSNLKILNVVNCSGIVKLSEIIAGLEKIPKNLKKPTVLYLSINGPKSNLFNRIISKITENNVIVVSAAGNNHDIACNYSPGSSENVINVGSINQDGDISKFSNFGGCIRIFALGEEIDSNSNLGNKLMGTSFSAAIVTGAVAIYLEKFPNATQTEIWNYLNSNSIWNKNGYLALKIPQLDKETDSIESTKNIIPNQSTYSFKTMCLKYYFIGITIPIICITFLILIILYFIRRHRTRKEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3U3</accession>
    <name>A0A4Q9M3U3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0099p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3U3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020975452" evidence="2">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15474" checksum="CBF961510631459D" modified="2019-07-31" version="1">MILIYLCLIFSSGIELMRKRSNEYDCKQIVSKKVKTDDKPFVPNESNGQSYNIDENGAPHDTEEIKIKAGTSYQMDNEEGLRSDSSESSFSNDSYTKADTISMDSASESEKIFDEFNNESEKVLSNLQGCSYENFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4H6</accession>
    <name>A0A4Q9M4H6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0040p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4H6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="54095" checksum="3636EFF3A3780D31" modified="2019-07-31" version="1">MIQIILFDGKKHLIFYIYLLFFTFINNSSENYDIAEYRELYVKKCLDLYNGEAKQFESLPKSMEYAYLNFYENRLGLAADAISNYIHSKTSSKFEISIYGPNPKRDYFSEPIQFKAFRLEPAGKKFWSISTLGINTSLGFKDSPRINPKMVFQNQLNMFLKHFFQMYRSIQKIILMRDNPEFAYISIDDTNNNVRKRVPKKYTDIKFFLLNNIYKVFCVQIFSDIEILDTNINKSRMKEVFTQKFGEMTYFFYGCYDIYVINISNDELHEYNYIKKIFKRFSIYRFRIKFDIGLPPQKHGNLILYPACPSFETAIHSTEFDYFYSTINVQHEDYKFKIFLKYSDKLFEFNFNWPEKHKLFENYVKNSSVYLYALSSSYESYGIEMMRDDDLKCFKDKRAAFSSDDFYLDCCGKIEYKYDRYYEYDEFFDMMIFHNKHNIYWNIILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVX0</accession>
    <name>A0A4V2JVX0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">CWI38_2722p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="PITK01002722">
        <property type="protein sequence ID" value="TBU05702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVX0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2722p0010"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU05702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16283" checksum="B8A9984DF2EA58A0" modified="2019-07-31" version="1">MKLLVTVGSTSFDLLIKKIVENIHILQKKFTKIFIQTGETNEKFNKIENVTIINYKYPLPIDIYDVILTHGGTGTILESLFANKSTFVIINENLKHNHQSDFVKRMEAYIHIVSLQNVIEMLIQDNLLPKKKLLPSKEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWW6</accession>
    <name>A0A4V2JWW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2139p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002139">
        <property type="protein sequence ID" value="TBU09552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2139p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="324" mass="37984" checksum="F1005C02B0743B2C" modified="2019-07-31" version="1">MNLCILLYVSETINSALRPIQKKELKIDFVYEILCKEAYRQYKEKVLGMHIVFEYNFLILEVIPNFVNECDLEVFNYLYREKLENTFLYLTTLIKEKYCTNPTLQNFLLSLIVHFNLQISCYHSILITKKGKKEISCKKNLANVLKNAFTSLFYVKYSYYKLEKEEYGSILERFESISNHSLRIGALNITSVGTNISSNKYDINVSALRSWIDKEPRNNIIRHSCIFRSLDLNISIKGPEFNDFQLKLVIKSSSNQNVTFDIDYNRKNNSVSGIACIEDCENFLIDAPVGEKLNFIIRYLNSKLDAHFQTNNYRLFQTEILFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWZ1</accession>
    <name>A0A4V2JWZ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_2132p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="PITK01002132">
        <property type="protein sequence ID" value="TBU09632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWZ1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2132p0030"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU09632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="39111" checksum="2B8246D98309BB7F" modified="2019-07-31" version="1">MVSDEKLFLIKRNLQEILSEEILTEKPKNEKIKIYWGTAPTGRIHVAYYVPLLKIRDFLIAGCDVKILLADIHAMLDNLKSKFEVVGFRTQYYENCIKAMLANIGVDSENSSFGKIIFIKGSDFQTSSKYVMDLYKLSSITTERDGKKVSNPLLSSLIYPLMQALDEEYLDVDAQIGGVDQRKIFTFAMKYSPQLGFKKRAHLMNPMIPGLNSEKMSSSDKYSKIDMLETKENIEKNIRKCFCEERNKETGLLYLIRHIIYPIFEIKNLKVEIFIKSLNKKNFYEKYQELENDFVEKIIHPQDLKKSVAEMVEIIVGPVRKEMEEFQELIQNAYGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC6</accession>
    <name>A0A4V2JXC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1280p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001280">
        <property type="protein sequence ID" value="TBU11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1280p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13274" checksum="464E06BEB36D24FB" modified="2019-07-31" version="1">MGVSYRIVNYKGVNNSTSNYHPFIVKEGVNDTSSNYHPFIVKECVNNSTSNYHPFIVLEGVNNTSSNYHPFIVLEGVNNTSSNYHPFKGVNNNRVIITPLGVNNSTSNYHPFSNLYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC7</accession>
    <name>A0A4V2JXC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1272p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001272">
        <property type="protein sequence ID" value="TBU11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1272p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="22199" checksum="04C167B5059F7E1E" modified="2019-07-31" version="1">MINEAINDIQDFSENIETTAIRGVENFEMIDSEETSFVSALNEENFVNVPNNIANTRALNGKDKCGGFFIPGLGFKLIDANSPLFPIHQRISRIRIEIDLFNKIVRDISKKIQQKKLKFAFSDFIINSLKVVGSFSESSIHSFHIFIVKTENILKACGASRIIFSLVLKFADNHCQDFESTIGMLNDNLKMILDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD3</accession>
    <name>A0A4V2JXD3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_1247p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="PITK01001247">
        <property type="protein sequence ID" value="TBU11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1247p0020"/>
    <dbReference type="OrthoDB" id="2195076at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="213"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="55655" checksum="930D6F4667F185AC" modified="2019-07-31" version="1">MKPVEKSESSSNWFPDSSLSQLKNKSKSFSMGSMKNTNFKKIAISNNLTDLREEKVKIVNITQRPSKFPYSKAKMVISKQNIMTKLFYNAMQDIGNMNLQIRNSLHEILEEIRKLKTPKKIQAIFMRTDYLLEKTTGEMKQVETNVIACCFIFLGPLLNKTHSLFYEKVLISDSNKKFINFVVTIFEAQDKNYLKNKNIGLMIDNETSIHCANFHDKIEFIKGIKEKGIDVFHVKVSDLQENIKIKLKNGETKNILNFIENKSNWREWNDCEIFFMDRKVSFVYYRWFYNAEHFDNESIIYRTLFEISDCVNLPSVELQIIGMKYFQILFKDKNILKKYLNIDEIEAIYSNFGDFKKLENFNFDDQFDYILKSDLEGGGHNIYGEDMLEIVKRKDEKYFLMKNILSPSFNNKFIDDKEERQVVCEIGIMGCLISSNGEIIDQQDCGYICRSKDVCSKECGVSCGYGALDSIYEFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD5</accession>
    <name>A0A4V2JXD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1220p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001220">
        <property type="protein sequence ID" value="TBU11412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1220p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="38828" checksum="6EDE260B19F75E65" modified="2019-07-31" version="1" fragment="single">MENLNTTSILEGNRPVIEFRPGCKEALYLLDKEPEVIYIVLSIKRIYKCFLTLRFLGRINDTSARKAACSAISKIETYSGVEDVCQHCNTPRESVEHLATRCITMPCHDYTKRYNNLYDAYIYSYRSDIILSFQNEFGVLENLLGIIYKCTVEIVPYGINWNGIDREISKKVPGIIERGVWPGKKDFYEQLKSKKIGHKQVNLKNIFALILEGFYSEDCLNGFMPNSSDSYPLESNIKENSGNNDQKLIFQSTHYTLDLNNVQIFENEQNEDRNMEKRYPRLYTDPKLLKNTSDNSLDEISSTVHFDSHISHDTLQNYKESYDFKLDCNLDDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK0</accession>
    <name>A0A4V2JXK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0881p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000881">
        <property type="protein sequence ID" value="TBU12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0881p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="79487" checksum="473C0E0F7DEF898E" modified="2019-07-31" version="1" fragment="single">MYEDNNKKSLNEKSNNRKNMDENESQEDKKDKCGGECKHDNTKCKECCGKSDSKLNNINKNNVVKKVCDDSKDSIGTSKVKKKRTLILTCKEENLVLDSEETNVENESDQSCSKCGKEKTKNKMCCKCMKKVEKRVIRAALSTPKLKKINDDFEISAKKKLYETFVSESSSYEVSEIHSSDSEEWGLDYIEECIEKIKPKKEKIKEKIITKKTDVNEDKKFDEDTESFWQHSDTSKIFSSFSEEEEEAEIRSRSKASTDPEISDLLRGENIRDDVFTSSNLSTQNPIYQSKESEENRSFESLEEVDVESFTGKNEKEEESLSNNKTPNIILYGSENLKIQDKKDTESDHDLTSTKENGERLKNEKEVETIKTEKKEEKEEDDAKDDSKNNVKPEEIIFIEENGNGKILGLESDQENENTNVITRNEGFSGIFTSLGLFFAGASIATTAQKNEHHKPSRDTQSSPELLDLLDSDSLAQNSDENNSNNKNIAEEISSSEKSASGANGSDENISTKEVSVSMAEVKKEPGELLKNTNIYENVDGSSLSDATKSSKEISNGGSTKSKENVKYDPFSTLSSEISENFPVQKGASFSKYHVENPNPTEAFSENEVVKDEKISDAFESKSKPSEDNPVDSREDKIIESNDPNKKVLDDRRTDNKGLTDQSIDKSDISSIKSSRESGHLSLERSDGNQNFSKPEEEKSSNERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR9</accession>
    <name>A0A4V2JXR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0602p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000602">
        <property type="protein sequence ID" value="TBU12862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0602p0020"/>
    <dbReference type="OrthoDB" id="2192975at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="738" mass="83406" checksum="36B8835801AE7A09" modified="2019-07-31" version="1" fragment="single">MKRDCTSEKDKKNISTKNPKLNSTLNHISNPSQFTPPRNKIIAYFFSFFLFLKNKFNFHKILTSIIYILFPRLKQFNKLVSPRPIQPLYLHSPSSSSSKNTLNREIIKEQISQNNHSKTLSRYRLNKKSGEIKIRSYFIPTNLIPSPIIFLISIFQIFAAQDFLNQCTLYNIPMNDCLSSHYYPSQQFDNFVHSFNLPIFKDPTCNTRKCYLLINNADPHTCKGSECNNSITLTPCKGQNCPTPPFDSCQAPNCNNNTPTNTTPNTPSNTPTNTCQGPNCSSIVTVTLYQTKTVTIDTPFTLFREITSTLTAEHLITRYKVTTLTSTQFQTVNNTLTDFKTTTDFKTVNNTLTDYKTTTDYKTVDNTLTDYKTIDKTITDFKTVNNTITDYKTITDTETDTLTTTITLPKSITKVKHKHITHTVNNTLTETVTDYNTITDYKTVNNTITKIKSFTDYKTVDNTITKVKPSTLYKTVNNTISISESLTNTNTKNNTVDYKTVNKTIIKTNPVTVNNTITDYNTVTDYKTVNNTITMIRPFTDYNTVTDYKTLNNTITEIRPFTEYNTVTKIKPFTDYMTVTDYKTVNNTVTDYKTVDNTINDVITEIKPFTFTVTEISSVVKTVPKNKTRYNTRTVTKGVTVVKTVPVISTVTESVIKENSKITPVSTSETMPMANTFCQTCTVTDITPVSTQADVTSINTLCLTESSSKITPVSSKEKGTVTNTHCETCTVTKITPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV0</accession>
    <name>A0A4V2JXV0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_1204p0010</name>
        <name evidence="10" type="ORF">CWI38_0494p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="PITJ01001204">
        <property type="protein sequence ID" value="TBT99820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000494">
        <property type="protein sequence ID" value="TBU13232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1204p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0494p0010"/>
    <dbReference type="OrthoDB" id="2190092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT99820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="215" mass="24798" checksum="B17CFB97B07DF493" modified="2019-07-31" version="1">MYISMKNPIILNPLATEYLLIFLHGLGDNGENISSIFESYAKRYRNTRMIFPTAMKRKIGICANMEMNAWFNIQSLDLEYEDYDGYRESMENIMKIFNEQNIAPTRTIIAGFSQGGAMSLYIALNEIRYFKSIICCSGFLIDRTNAKNIVKQNITMIHGNKDIVVLPMFGEKSFEILKNKYKQNVKLIKFHGDHTIPNIAFDTIFDGFNDKDLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY52</accession>
    <name>A0A4V2JY52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small subunit of replication factor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0210p0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY52"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0050"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="47580" checksum="E1FDB851AADF4543" modified="2019-07-31" version="1">MSLLVEKYRPYSLTEVIGNKEAINTLKLVLSSNTLPHLLFTGPPGTGKTTCAKILGNRLSKDLLELNASDDRGIDVVRTKIKNFTLRKVDPKNNLTNKTNPNPSLTPNTRINSYKIIILDEADSMTTAAQQALRRIMETSKDTRFILICNTFSKIYEPIQSRCAVIKFERISDTEIQQRLSFIIEKEKIQVEEGVIQTISDLCEGDMRQAINTLSSVVFTKQHPIEKPLKEKENIKATNITNKEDTTNIEVPIITPSKDDNENHSKLTHCNYNTCNLTPSKDNNELDSKLTHVNHNTSNLTPFKYNNENYTILKPFKVTTDYITKITGVPSPTKVKSILNLLLQKNEEEALKEFEEIWNLKYDPVDIISAFFRTAKYLENYELIKAIGMCHVRINEGFNSKIQFYGMFYDILNIKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN6</accession>
    <name>A0A4V6MVN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0364p0010</name>
        <name evidence="5" type="ORF">CWI38_0364p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000364">
        <property type="protein sequence ID" value="TBU03057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000364">
        <property type="protein sequence ID" value="TBU13682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN6"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0364p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0364p0050"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="199" mass="22750" checksum="0B4C92D3DC2CCCCB" modified="2019-07-31" version="1">MIDEALKTTSSEEDTFEVQIALKGYDYNKDVRFDSNVVLPHPKRKNEKILIIADKTLEQKAVSLSLPFVNYESVQGASKERQKLKGKLCRRSHSLIAESTFNKAFEMRIINRKRKPLFIIKNVGDLQNFYNDVSKTVKFKLRKENTLSFPAGYAEMGSEKIVENVYLGLTHLLGLLKKGMRNIDSIFIKTAKGKPVKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUN5</accession>
    <name>A0A4Q9KUN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1711p0010</name>
        <name evidence="3" type="ORF">CWI38_0019p0060</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001711">
        <property type="protein sequence ID" value="TBT98538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1711p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445299" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="107" mass="11890" checksum="ADCFDFED555900A9" modified="2019-07-31" version="1">MKVVLFSAITFFLKYQIILSNPDTKSIKTFLTENMQNSTPLGGLGSTRNSLKNSFFKEGHLTTGLGRFLLSNQLKNNPQLRSRINKLNMGLGNSSDLVSKKTAKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUZ3</accession>
    <name>A0A4Q9KUZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1653p0010</name>
        <name evidence="5" type="ORF">CWI38_2298p0010</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001653">
        <property type="protein sequence ID" value="TBT98668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002298">
        <property type="protein sequence ID" value="TBU08157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1653p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2298p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120543" evidence="3">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT98668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU08157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="102" mass="10661" checksum="21858E1F1CCFDFC6" modified="2019-07-31" version="1">MNKYLLYTLFIVSVFCSKGNSKSEDDNPTNPSKATTSGDSANDTKKSTATSNNTDEEDNQDNTDNTNDNSNGKNRDSSINGVGGACVGISLVMLLASLAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KV42</accession>
    <name>A0A4Q9KV42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1749p0010</name>
        <name evidence="5" type="ORF">CWI38_0381p0020</name>
        <name evidence="4" type="ORF">CWI38_0474p0040</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001749">
        <property type="protein sequence ID" value="TBT98455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000474">
        <property type="protein sequence ID" value="TBU13301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000381">
        <property type="protein sequence ID" value="TBU13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KV42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1749p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0381p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0474p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445328" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="106" mass="10601" checksum="8ECD4B5F6DD4246D" modified="2019-07-31" version="1">MQKICRVFLFIFLCVINIVFATPDKSSDKSSSSESKTSEKDAASGTNSTTGDNATSSNSTSAEGNATGAANPVIGGIGGIGGISSEGGAGNATKANFSRAELILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KW42</accession>
    <name>A0A4Q9KW42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1814p0010</name>
        <name evidence="4" type="ORF">CWI38_0110p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001814">
        <property type="protein sequence ID" value="TBT98299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KW42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1814p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120544" evidence="2">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="322" mass="33874" checksum="E008BCF51B4002F6" modified="2019-07-31" version="1">MIFIILQIFLSKYIECGVACGSSRDANAYYIFSEEPAVIEIPNQGQEVMFSQPSSNVYEYSYKDPNTNSWSQPVIVNVGDYPSQYSNPSTTYQQPTQTWTQPAQTWTQSAETYTQPTQTWTQPAETYTQPTQAWTQPTQTWTQPASTSTQMTAQAWTQPAQTWTTPTSTSTQSAQAWTQPTQAWTQPTSTQTWANPMPVYSDIQGTPMTSGANGEIVSVADSNTSAAIVGVGAGTAAGVTAAGASTSGGSSAAMDSAAAGGNGSSSNSTSDKNGNKTKDKNSTKGGGSKSSNGKNNMKSKNGAGSAVIITGLLGMIASAVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L087</accession>
    <name>A0A4Q9L087_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha,alpha-trehalose-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1170p0020</name>
        <name evidence="2" type="ORF">CWI38_1926p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001170">
        <property type="protein sequence ID" value="TBT99919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001926">
        <property type="protein sequence ID" value="TBU10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L087"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L087"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1170p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1926p0020"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="493" mass="56970" checksum="31DB19F570AA72A3" modified="2019-07-31" version="1">MRLIVVSNRLPVKVNKVDNNFVYKQSSGGLATGLICLKNTTDFIWVGNMNLKDFSEEEKVVVEKDCWEKYKSIPLFLDPELDEKYYNGFCNCILWPLLHTFQDEVTFSLANWEAYTKASEQICEKIASFTEDGDIIWVHDYHLMILPRLIKEKIKKNIKIGFFLHTPFPSSEIFSVLPVRKDIILGLLSADLVSFHSYEYLTHFINTCEKMFPKIENFCNGTDFKALKIISDENEDIKKLKLIYEPDNIQIGHKTIQVAVTPIGIDPKMFTDILKREKCRARINELRRIYKNKFVFLGIDRVDYIKGIPNRIQGVERFIQRYPEYIDNFVFLQIGVPSRIDVVEYESLVSVINMKISELNSKYGSVDQTFFYFLNKSVEQSELCALYALGDSCVITSLRDGMNLVALEYISCQEDNKGILILSEFAGAMQTVPGALSINPWNIDEIADAMKNAMVMTQQERKERYDINKIGIEKFTAAKWAKDNLDILMDLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3A4</accession>
    <name>A0A4Q9L3A4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0838p0010</name>
        <name evidence="5" type="ORF">CWI38_0689p0030</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000838">
        <property type="protein sequence ID" value="TBU00990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000689">
        <property type="protein sequence ID" value="TBU12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3A4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3A4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0838p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0689p0030"/>
    <dbReference type="OrthoDB" id="2194947at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="405" mass="47371" checksum="283734722CAE4547" modified="2019-07-31" version="1">MKNIFEEVLKINMEKDTLLRKQKVIRICNEFIDFLLQNKEEENYLLYKKIACRLVEYCEMFKNIKNPFLGKTIIEEVKNILEKENGKFICDERKIHKKVEINCGKNGTLEDVIGLEKVKTMFFDSIKLPILHPELFIGNRKPPRCILLYGPPGTGKTCIVNLLGSILSNLKIIQFSASDIFSKYVGDSEKQIRNIFETAENNMPCVIFIDEIDFICQERINNTNECNNRIKSELLIRLNELDTKKNIFFVGATNFPWSLDHAFIRRFHKKIYIGLPEVEDRIKILKFYLSKNSNKLAEQDYTFMAENTNCFSGSDIKNLCENMLCLTLDELKKCKKFIRENNIYRPWKHGDSDPLICSFEEIPGTILEPPLLLTHFQEAIKNSKSSIKKDEIIKFIEWTNIYGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3R1</accession>
    <name>A0A4Q9L3R1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0550p0020</name>
        <name evidence="2" type="ORF">CWI38_0495p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000550">
        <property type="protein sequence ID" value="TBU02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000495">
        <property type="protein sequence ID" value="TBU13231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3R1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0550p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0495p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="272" mass="31973" checksum="47D32943069AEEE8" modified="2019-07-31" version="1">MQEWKCFDDNQLDEEIMKATKINFLISNRESFKELCVILSNAKYEFFFGFFTTLKIDFVGKAGGYLEFFVKSTSENLKIFSEFLEEINNTVEILNKNIYSESGDHQHKDILEYISKPIITKVLSDSIQFNKICEFSNNMGTFQNETEDLNFPRILIEIFYEENEVNYIKTLYEWLMKKKEYHKYISAVLCLKAFCFKGKFSDKNIISRILIEFLFLADVLKRELHKTGNVEEINKCREVYVNGLKAQIEFSNKKYADNTPVGYLGDSKVLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L858</accession>
    <name>A0A4Q9L858_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0281p0030</name>
        <name evidence="6" type="ORF">CWI38_0202p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000281">
        <property type="protein sequence ID" value="TBU03526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000202">
        <property type="protein sequence ID" value="TBU19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L858"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L858"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0281p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0202p0020"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="210" mass="24763" checksum="B1FFF4C7C3B110ED" modified="2019-07-31" version="1">MAILYTQLLKPSDLQILACSFSVHGRVLSSEKKILLELRNIIQKMPDRVQNVLYDYKYGDIAIFYIYIINDVIYALITDKNDDAESVMKYINRIYSLFTKFCVERGSKPYTSFEEVLRAQSDIFNSKSDVFETEEELKMAKDVCIQSLDKVFKRGEKIDNLLNLADRLKVAAQSLQRNTRRMYYQNLLEQYSLYIVFALIILLVFYFFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE76</accession>
    <name>A0A4Q9LE76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2611p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002611">
        <property type="protein sequence ID" value="TBU06248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2611p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="16369" checksum="D69891014E420163" modified="2019-07-31" version="1">MTAISVEDIRKKYGDVREYVTTKAMCAKKVLNNTYHNYKVYPMAYYSWMKSYIKKKYQKEEKPMELEPTKQQEEKSIDFESMPEYQELLKFLASLEQKGFNNTEKGKEEDKEICEEEKVESKSGSEEEEEEEREQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEC6</accession>
    <name>A0A4Q9LEC6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2600p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002600">
        <property type="protein sequence ID" value="TBU06308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEC6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2600p0020"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17128" checksum="2BA4261246045F90" modified="2019-07-31" version="1" fragment="single">MFYSQKKEDEVTWQKINMSFERSKTLTESDFLQFLIQTKDIIIRSMASERSKLSGTTLSLLNNAIIIISKEKNNEIVTKIFSFLDSILPTLIKLTGKSNKVICTRAECTLIEMGKVLSLTRHISLLKDSLSSISKNIRLGVYKLLESNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LER5</accession>
    <name>A0A4Q9LER5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2644p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002644">
        <property type="protein sequence ID" value="TBU06096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LER5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2644p0020"/>
    <dbReference type="OrthoDB" id="2198700at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17474" checksum="AD1B45C98E7E5E48" modified="2019-07-31" version="1" fragment="single">MIFGENKNNERTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEADRNVFWGADSVCQHCGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF36</accession>
    <name>A0A4Q9LF36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2539p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002539">
        <property type="protein sequence ID" value="TBU06607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2539p0010"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="22718" checksum="13DEC17CDCC523B4" modified="2019-07-31" version="1" fragment="single">MMGRRKKVDSENIKNDEIKAVNNSEISFKEIKTCDRYVVTISEALPPQQTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGKFGRTVDIDVLKKLIHNEAEREIRQEENGERRRIATCLAELCSLTDTTLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF39</accession>
    <name>A0A4Q9LF39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2613p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002613">
        <property type="protein sequence ID" value="TBU06236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2613p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="607" mass="67611" checksum="07675E35E358D910" modified="2019-07-31" version="1" fragment="single">TTNTLLHSSLTFKYLQISPTLYNITDITFISYSLHPTLAFLYNNKILITSYNYNTFIILSTHTLPLYTFKLLYSNEVLSCIGNNSVVFICKGGVRTVNINQYSRGLDKGVLDREMDGGLGKGVLDSSNDGTYDKGVLDNSEDSTYDKGVLDNNNITYDKGVLDNSEDSTYDNTPYTNTTNNPYNKTTNNNTNNTPLTDTVIYNSISTFINNTLLIFIPGITLIFTINKEYNTIKDIITNKIKGCYFPTCISNNNNYIIIGSNRSNMYLYGINRRRGVNINNVSDILKYYEMKGGNGGGEFNNSNNSGSNSDRCDTNTITDNNTALIDSNNIDTNNPNPTLTLNECINNNIGNTNSNTNLLDTNPTLTLNKCINNNINSNTPNNPNPTLTLNKCINNNTNILISISLVKVYETFGCITSSVMTGGILNMEMIFSSENKKVIKVFNRLEFAVNRSVKVKGFNKVFVCDRVVGGVNNNVYDYKGVSNRNNELEGVSKRIDDYKGVSNRIDDYKGVSNRNSELEGDNKRIDDYKGDNNRNNELEGVSNRNNELEGVSNRNSELEGVSNRNSELEGVSNRNNELEGVSNRNSELEGVSNRNSELEGVSNRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI76</accession>
    <name>A0A4Q9LI76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2340p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002340">
        <property type="protein sequence ID" value="TBU07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2340p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24188" checksum="58CEF96DDABE90BF" modified="2019-07-31" version="1">MLGHDYTRRHNEVFKSSKRIRSHLVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDMKKNKIALIEVGITSQDSLQIYHLLANELSLFYKCSVEIILYVMTWDEIPMNVEAYIQSLVLKKTVETISFDRRRGLESGLNAEESWECVSIGIIMRRDEDGVKILKIKNNTSLISQEGTTLEEPTNNINEESDLEEETVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJG5</accession>
    <name>A0A4Q9LJG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luc7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2297p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002297">
        <property type="protein sequence ID" value="TBU08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJG5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2297p0010"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="29051" checksum="B4D1475ACAF9A8F6" modified="2019-07-31" version="1">MADRARLLLDELMGKDRDSIHKITEEYSFNNTNICKYNLVSFCPFNILKNTKACSNTCKYTNHEEYYVSLYNKNGEKYRKKYEMEMLNLLKEFIFNMEIRKSKNQDILDEKNINNYKSYESSNKSNNQTINVENVDELKERISIAEKKMSEVLVNVKNLFMVNKVSEAYECLLFLDKIKFDSEKLYEKLDSNEQRKNLSVCEICGALINMKGIQSRLNNHFNGRMHKGFVKIRNVLADLLIKYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJV4</accession>
    <name>A0A4Q9LJV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2261p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002261">
        <property type="protein sequence ID" value="TBU08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJV4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2261p0010"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="36460" checksum="B50DD33ECFBB2DEE" modified="2019-07-31" version="1" fragment="single">VSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVNICSIRQHPVSDSTNNYKGISNSSNEQQGVSNSSNEQQDVNISSIRQHPFTNNIQINYLLDLYLTIKMYLPLEYKFLLTNILGDGNRSSVEGGYVRGWWGLEGMEKGVITKDMLEGVSLLEGMDKGVITKDVLEGVSLLESMERGVITKDMLEGVSLLEGMDKGVITKTSNIRGVITKDMLEGVIYRICVSDTGSVDVLYLSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK35</accession>
    <name>A0A4Q9LK35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2-like putative regulator of chromatin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2239p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002239">
        <property type="protein sequence ID" value="TBU08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK35"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LK35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2239p0010"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="111"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="376"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="546" mass="62839" checksum="A6A824DE998F1CD2" modified="2019-07-31" version="1">MPSIPVVNKPVKMKLKEDGSIEVKPSNKIISTILTSFPNKKSTYILETNSWKINIEIYEDFCIKLKQNKILYEEIPKGVINVLKKNIKNEFYDLKNGIYSYLLPFQMQGVNFALNRKGKILLADDMGLGKTIQALAIAYYYKLEWPLLIIAPASLLYNWAESINTFLKMESTIIRKMSDFGEKISIISYDQASKNSDLILKLKHQVIIVDECHYLKSQQSKRTVNLLPIIQNSTRSILLSGTPAMSRPLELFSIISAIDKFIFPKFYEYGKRYCNGRKVGHWYDYKGSSNLEELNYLLNKTFMLRRTKECVLNELPNKFRRHVILNLDDSKTENKDSTSLNKILNENKKNIDENLTEVSDNIMTLYCEAGKLKANKVIEYLSCLIEKQIKFVVFAHHGFMIEQISKFLEETGINFIRIDGKTPVNHRQQLVNKYQNNANITVALLGLTACASGLTLTEGKAVVFSELYWNPGTMLQAEDRIHRIGQKDSVDIHYLIGKNTIDEYVWPKILKKLNVLESLGIGTNDLKDIGPFDLKQKRLENFLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL76</accession>
    <name>A0A4Q9LL76_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_2188p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="PITK01002188">
        <property type="protein sequence ID" value="TBU09069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL76"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LL76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2188p0020"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU09069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="370" mass="41950" checksum="2A54BB29517DA70E" modified="2019-07-31" version="1" fragment="single">MSENQTNQKFTDLPLSKETLAFLNENGFDEMTEIQSKSILPILSGVDVLASAKTGSGKTLSFLIPIVEHLKMLDFKDKHGTGALIIAPTRELAIQIFNVCSKLIKYHNLSVTIVIGGINKKIEDENLRKGCNIVIGTPGRLMDHLKNTEKFKISNLKILVLDETDRILDVGFEDELKNILKLLPENRQTLMFSATQTSKLEDISRLSLKNKPLRIFANPSNHDDLICDNLNQFYILATESKRLAVLYSILKRFKNEKVMVFFSTCNSVNFHSQLFHFIGFKIISLHGKMNQIKRSNSFKNFEKEKTSILFCTDVAARGLDFSNVSTVIQYDVPVDVKEYIHRVGRTARAGKNGNAILFLIPTEEKYIKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLU3</accession>
    <name>A0A4Q9LLU3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2206p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002206">
        <property type="protein sequence ID" value="TBU08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2206p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="35057" checksum="60780B3AF3F4A3D4" modified="2019-07-31" version="1" fragment="single">IRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSIQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANEFGLIYKFSVEIIPYVITWDGIVTKYHKSQLKRLEIPMNVEAYIQSIVLKKTVQTISFDRRRGLESGLNAEESWERASMGLIMRSEMHEEPITPLKEGREEDGAKNFKPKNKALFISQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMB3</accession>
    <name>A0A4Q9LMB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2235p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002235">
        <property type="protein sequence ID" value="TBU08645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2235p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="40169" checksum="C26590FF777AE811" modified="2019-07-31" version="1">MVDVRDFSLFEFLYDNKVGYTSSVIEKHISNSDICGFSCLFEFGSEYKFSTNEYFLKKVFYFLEKLSFDFEEQFSDYFFYKIIKNCLFLVVDEEISIEWLRGRYSCVDLSGGGLLGFSICLLGFLAKHEELFLYIQNSVFWHDFYNLFDENTKENVFSMNLTTKFLEISSLDCSRQLRFKNYNREIVAMMYNLRHVESMEFFGIEECTTEIFVLKKFKNLKNLSLQFEDNSKERTFDLTLISHLCDHFKNISHLEVTFNNLNFDFEDYSQIVFYASENLKFLKLKGISFVQDIKKLIEKSVNLETVILIGKYKFLIIQILKELFCKPNFKNLFLDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMN3</accession>
    <name>A0A4Q9LMN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_2131p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="PITK01002131">
        <property type="protein sequence ID" value="TBU09643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMN3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2131p0010"/>
    <dbReference type="OrthoDB" id="2194727at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="304"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU09643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="661" mass="75048" checksum="FB33E257FCF1EA97" modified="2019-07-31" version="1" fragment="single">MKKTLSSYNTTSTKIKEIKFKIFSTDQINRLSVLKLTKKEMYDSTTKQPMPNGVLDTRLGISNKTGTCSTCNQSIKDCAGHFGSYELILPVFHIGFFKHTCHILQCICKNCGNILLSPLKKHFYTQKVQSLRNNIIFYKNILKKIMEECKKFHKCYICEYINGNIKKGTGFKLYHEKNVIFKDLEGNSSYRDVNNLLSTRDNSYGNNSYGNNSLSMSRNNSDKIVNNKLSTRDNSYVNNSLENNILETNSLQKNKTLKTTNNSLKTTNTKEKIKEELNPQTVLNLFKKIPLSDTNLLGISFPPKDLLIQTILIPPACIRPSVATETENGSNEDDLTVKLSEIIHTNQVLIKGLQKGNQLSIISEDWDFLQLQVSLLINSDLPGISNNTQIKPIRGLIQRLKGKHGRFRGNLSGKRVDFTGRTVISPDPNLSIEQVGIPIQMAKTLTIPETVTKYNIQHLKSLIIKGPHTHPGANYIYNKKTEFKRFLQYGDRKKISENIFPGDIVERHLQNGDIVLFNRQPSLHRLSIMAHHVKVMPYKTLRFNECVCTPYNADFDGDEMNIHVPQTLEAQSEAHTLMRVRNNIVTPRNGEPLVAATQDFITASYLLTSKDRFFTKQRFSQLICYFLGVDICNTRDIGSSSNKGNTRDISNTRDIGSRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNT5</accession>
    <name>A0A4Q9LNT5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2043p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002043">
        <property type="protein sequence ID" value="TBU10078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2043p0010"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10275" checksum="7BA0234298924E29" modified="2019-07-31" version="1" fragment="single">RVRENIALQINELGQVVSDISLHVSMQGENLKRIDDLMGDSRGFVQKSTHEINKTWNMIRNRRNTFIKFFGFWIFLAFVFWILKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNU2</accession>
    <name>A0A4Q9LNU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2175p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002175">
        <property type="protein sequence ID" value="TBU09185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2175p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="52262" checksum="841B8F06F26DA23B" modified="2019-07-31" version="1">MYLEIPYEIGENDEVKECFDKLELDIKDQRKEKVIQITSFCYNKIKEYTNVKFHPFILYFTTYICYFVYRDMQFDVKKYRPELLFNLITFGRFWNKKDYNILKEKHPKICRNIENSLNQDNKIDIFVLENTKFIKGYSSEASKSKISINLANATVENYFGFFLIINQRFFKGKEYRVDITRKSAINKSTISFLELKIMLEKTTGCINLFSVMIDFESYKEIAENISEPIFRTILKDSNFSLEFIENIVKKKEINYIKSLYVFLKNISKTEYHEYIAAVLGLKAFCFKEILRSVLEILFLADVLNIEFEKINNNPSIINTYGVPFIAVIKNYLDEQRIEYDKNLVLNTFNHFLLPRTFSILKTFIFVNLFANSSWKGDYNKELKEYFTKNKKNVDEEVVVNEKNIILYVFEQEFSKLSPEERKKIFTIPVTKTPISDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ89</accession>
    <name>A0A4Q9LQ89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0589p0030</name>
        <name evidence="3" type="ORF">CWI38_1499p0010</name>
        <name evidence="2" type="ORF">CWI38_1634p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000589">
        <property type="protein sequence ID" value="TBU01960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001634">
        <property type="protein sequence ID" value="TBU10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001499">
        <property type="protein sequence ID" value="TBU10872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0589p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1499p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1634p0010"/>
    <dbReference type="OrthoDB" id="2192252at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="182" mass="21509" checksum="9AF13A77AFD985E1" modified="2019-07-31" version="1">MSKKIQFNDISDLNEIFNVIEEILPPKKEEDILFLKKLRSILKANSSFTKEEPKDTILSKIAEKEEERDIKMVDLAFSRRDLPLQLSVEYQKNIQAVKNQLQEFKEQKSINETTSRKSSHKSLFPPEYYNNILKDILHIKNQIPVYKTKLDRTKEIILSEQTEPKSCKRSMFDTINNIFNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT5</accession>
    <name>A0A4Q9LQT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1665p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001665">
        <property type="protein sequence ID" value="TBU10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1665p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="18046" checksum="A0C0ABEF8D5878A8" modified="2019-07-31" version="1">MFAFFIDLYIKKVVIIKEKYLAALKQNLALFNLIEPNYRLYENYGYEKHTTGKFIMLISLMTGFKYFYSSDMLQIKLENRTLPTVVTGIFYFLIIDVIISLWVLFVHIKRNMALTFVDSSLNKEGKGELFYNSLRVLTTKDGFYLDKLTIWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR71</accession>
    <name>A0A4Q9LR71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1244p0020</name>
        <name evidence="2" type="ORF">CWI38_1401p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001244">
        <property type="protein sequence ID" value="TBT99710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001401">
        <property type="protein sequence ID" value="TBU11073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1244p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1401p0030"/>
    <dbReference type="OrthoDB" id="2158148at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="179" mass="21244" checksum="9D157750BCA0114A" modified="2019-07-31" version="1">MVLHNSDIDNTVCHMDETYDANFGEWIRNEENARIVGCNLKKYINEYQIADFVVVLKWIVKDWTLRSIIVLVKKMIVDDLYRSSKTEYKRRIQLIKELICTWNPIFICEFILSVTKNFTVSEKVKFITHLLSSIEKQKSTDIIYHLIDKLDPKVKNMIRRTLVDRTNNTKRNKEGCRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR93</accession>
    <name>A0A4Q9LR93_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI37_0030p0050</name>
        <name evidence="17" type="ORF">CWI38_0190p0020</name>
        <name evidence="16" type="ORF">CWI38_1478p0010</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FI-OER-3-3</strain>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01000030">
        <property type="protein sequence ID" value="TBU05252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001478">
        <property type="protein sequence ID" value="TBU10914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000190">
        <property type="protein sequence ID" value="TBU19833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR93"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0030p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0190p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1478p0010"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU05252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU10914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU19833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="264" mass="30729" checksum="81A88CDC3A62AA53" modified="2019-07-31" version="1">MDESAIKNVWRDNLEDEMAKIRNLINRYKYVSMDTEFPGVVAKPMGNFKTTSSYTYQQLRINVDLLKLIQLGITLSDSDGNKPSPVCTWQFNFEFNLEKDMYSQESIDLLIDAKIDFKKHEMYGISVEEFGELLITSGVVMSEEIIWISFHSSYDFGYLTKILTGNPLPENEEGFFQYLKALFPNFYDMKYLMRTSKYLKNGLQEIADDMKIERLGTQHQAGSDSLLTCFTFFRSRDNMFNGNIDESKNLCRLFGIESKKYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF0</accession>
    <name>A0A4Q9LRF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1353p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001353">
        <property type="protein sequence ID" value="TBU11153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1353p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="27737" checksum="988A65075BDBAF0F" modified="2019-07-31" version="1">MKSAKDSKMESTMENAKDSKTESKIECKLNSKKNLRIECKIESKIESKIESKIESKIESKQKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASMGVIMGADMHKEPTPPSKEVKTEEDSVKQVNSKNILPLIIDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW7</accession>
    <name>A0A4Q9LRW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative spore wall protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1297p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001297">
        <property type="protein sequence ID" value="TBU11259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1297p0030"/>
    <dbReference type="OrthoDB" id="2191916at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="26301" checksum="DBD02B534E949B99" modified="2019-07-31" version="1">MKDRFKGFLRQMSTMDYKYTKVSEEHEKLEQKYRLLRDFLTVYEASCDKIMTYEHGGKTYKNVMEALEVVGERVNLQAFKVNNIYEQASLVVEKMADIHATDALNKTASDYSKALGEIGHKKTIMNGKFEDQMMELQKIKSRTAFIDKQRNITKNIRFDLEKAYKNDPDGVNIPEDLKNSFQAHLTDTEKYMREFVENKDVIGVINGCVEAQKTFHSAALEALKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD2</accession>
    <name>A0A4Q9LSD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1599p0010</name>
        <name evidence="6" type="ORF">CWI38_1748p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001599">
        <property type="protein sequence ID" value="TBT98785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001748">
        <property type="protein sequence ID" value="TBU10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1599p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1748p0020"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120575" evidence="4">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT98785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="322" mass="38553" checksum="FDA2F4F09C87E0F5" modified="2019-07-31" version="1">MFLLLYFILQILTKENAVIVILCRNEEMNQISESIKNFEEIFNKQYNYPYVFLNDNDFTEEFKSKIKSVVSSTVEFGKINYPMWGPPKHINMDKAKENMKSLESQNIIYGGSLSYRNMCRFFSGYFYRHDLVKKYDYYWRIEPGVKFFCKMNYDPFKFLRESKKEYGFVITIREYMQTIPTLWDATKEFLSLHRNKINIPVLDFIFNDDLSYNGCHFWSNFEIAAFSFFRSDIYQKYFDFLDSKGGFYYERWGDAPIHSLAANLFLGKDKIHFFEDIGYEHPPYQHCPKSPSRLTECTCTPNNSIDMAQYSCLKEYFVSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST5</accession>
    <name>A0A4Q9LST5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1328p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001328">
        <property type="protein sequence ID" value="TBU11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1328p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="383" mass="45022" checksum="2B549E64305BC24F" modified="2019-07-31" version="1">MFYDKVFEFLKNFTFSNLDDIETNLPEYVYNQMERVLAKSVGQKINSEFVESFISKLKYIDSDENAVIITYLFNKYTKILFKILKYFDEYHKARKFLKNGESISLSTTCGINGQITFNKAIFNAEFLEKGYDNLVLLDKLTALICNSSVYLSEKMCFNGLNKQANHDQFDLFFDGFDTYNLFELNTAEPAENFKQKFIDFLKLNTIKKFEKVKNDISRTKIYFVLNYINILNNIKDMDWIKKFLDEPFSSGFVDIIQVLKTISNSLQLINEISSSDFDLYLVFEDISRFDCDKIFQKYELPLDLSRDLSPNQTTMSRDDIMEKFKKASFSIFIFLIRDLLNNNSCYKSAGFSIKAANFSNEWTLVQSFDFFVRMKKGMSIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST9</accession>
    <name>A0A4Q9LST9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1096p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001096">
        <property type="protein sequence ID" value="TBU11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1096p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="23439" checksum="C50B4869CD0D79C3" modified="2019-07-31" version="1">MVILELLEENARLDKRKFMESQPVDYTLTDNTLLCVTPEISYFLFLNSYFTSPYVDRPCEGNLTFYSPFKTINRYISLLFIKMHILNIESLCVEPGVLSTFLNISLSTTSTANFINPSHLIHSLSYFLNNLNFKIVKIFPYFFISVNQHLLLDPVQEEYVNRDYRIFCVTNEDKDILFFEKNGKECSFKEILSVMEIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT44</accession>
    <name>A0A4Q9LT44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1269p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001269">
        <property type="protein sequence ID" value="TBU11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1269p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="349" mass="41389" checksum="ED950043BD1937DA" modified="2019-07-31" version="1">MPPYIFSLYKLKKFKSKYNPSFLARFGLFITKNSSEINFIHKLENLFKELESNIKNFGILNATFNHSLVDITLTKPNNNNFDTFKSIKISLNHNDPKVFFIFLLHKANIFDKKNIYGSLLKNIFPDNVLKQMLINILNFYVKMADEIRDSLSSYIHRIEEFRDILNKIKQRLENEKSLDWVQKELESLVFWYIKTILSILIDQKDDILNYLDNPKTLFDIFKKLISTQEEESTKILEIFDEFQNTNEEVIIKGLSSVKKFLLNFYKDYSDKKFGTTDESNLRGSAKFLQTEIVKKIYEDSTILDLYTNLITIAMKKTDNYSEEIILIVCQIIREVFLFYIRLYEAIFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE8</accession>
    <name>A0A4Q9LTE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1575p0010</name>
        <name evidence="2" type="ORF">CWI38_1213p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001575">
        <property type="protein sequence ID" value="TBT98830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001213">
        <property type="protein sequence ID" value="TBU11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1575p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1213p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="162" mass="19226" checksum="3B0E3F328320A287" modified="2019-07-31" version="1">MLEEFEDFRIIKNETMIFNKKNCIIFNKKKQNNEKNLNENLESLMKNYNENQMIKSEIDDKISIETEFPFNPILKSNKIGGHISTELYYKYLIVKILKILDIHINLKIIVLSEVCEIQDFFEGFFIFLEKIEASKSKCEFICQNDKEIILINGLVVYENNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN9</accession>
    <name>A0A4Q9LTN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1456p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001456">
        <property type="protein sequence ID" value="TBU10965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1456p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="570" mass="68100" checksum="331E8F56F39B9876" modified="2019-07-31" version="1">MNFFIFFCKIICASEFQYTAISEDSLSIDHNYLEISYEIGVDDQVKKCFDKLEFDIEDEKKEAMIKITSFYYKKIQEYTNNESDTFLAYFTTWICYYAYRHDTIIYKQKYRPELLFYLIRFKKFFEFCKEDKNMKSNIKDILVKLTTYRLQEKNDNYEEWCKQNYDSLKEKYPEICMNIENSSNRDNKIDIAVLENLELKKNSYEHYYYEIGNNLICATHEYHFGFFLSLKCMFLLGKKNEYFTLESLTEKEITTPHDIFEIFKLAISHIHESFKNIDFESYKKITEYISEPIFRKILKVKEDGFEKIYEFSGKKDLSNIEAGNSNSSLEFIQYILERKEINYINALYVFLKTISKTEYHEYISAVLCLKAFCFKEIVTCKQTMLRSIVEILFLADVLKIEFENENKNASAINTHSTQFIGFIRKYLDGQRIEYDKKLALNNLNHCLLPRTSSILKTFISVELFTNFIWKGNYNRELKEYLTKNKNNADKEVVVNEKNIFLIVFEQEFSKLSPEERKKIFTIPVTKPLTSDNKNESKEFGIKDFLLFVLIPIVLFGGVLLGAYWYIYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW4</accession>
    <name>A0A4Q9LTW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1114p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001114">
        <property type="protein sequence ID" value="TBU11616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1114p0020"/>
    <dbReference type="OrthoDB" id="2190329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="405" mass="48398" checksum="AAEDC056781A6B2A" modified="2019-07-31" version="1">MIFSFLSKNLNFFTFHERKIKFIILIFTLYFSKIKRSEDSVLSKESLYCRINCIDSILMDYKDIEEVREGEGDCLKYVLNDLSDNQSIYIYIKCKNANKYLKIFKSLQFLGEKFNILFKENEKFKEKNIFEKIEYFKEKVEDVCVSRENILGIKKDIDESNSKVVFMVEKVMKCMDDLKDDFTFCNYLKMVSSVRNMKCKVKNIKIILCSEILKKKGDSFLDINLCFGAETFVKIYPFLNFQCNSDILNMGKYFFESKVFYKFENKFNLSNKIDICLSEEMKSGKIFLCFLRALNNMHSHSLGSYFYIPFENYCVEMVSLFPFMVLNMVYCLVVYFFGKKKEFKFSYFHVLYIAYPFFPLICVFFLFSEIYLQGIMCVLFGVLNFSVGIIYNYVVFYKNLYEFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU10</accession>
    <name>A0A4Q9LU10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0888p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000888">
        <property type="protein sequence ID" value="TBU12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0888p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="14226" checksum="A72CB4F9216F94DF" modified="2019-07-31" version="1">MDLKLEKIKDKCFRENKSEEERKAKLARLKALRENISEEERKADLTRLIAPRENKSEEERHLERLRLQNLRKNRTAKNASKETQRNKNSHRISRKRLMTEQPLCIALNELTEFDEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU14</accession>
    <name>A0A4Q9LU14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0890p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000890">
        <property type="protein sequence ID" value="TBU12119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0890p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="47168" checksum="80453E49758CEDC8" modified="2019-07-31" version="1">MLVHDYTRRHNEPVRCQNLLLVKRYKSKYKTNLKPLSARNSSKQESGDNLDKKKNTITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLKIPMNVEAYIQSIVLKKTSGLNAEESWERASISEPIPPLKEAKREEDGEGTTLEEPTNNINEESDLEEETKVVKENRIILSIAEIQTQSSSKEPKKTLETAIKRKTSTENHLVINMLFQGFSNLIADIICYFPNFEDLYKFLEDNDEKKLEYRTDLFSNRLIFSPIKSKYRMESIDDLSFKNLNLRVLKIFSKYKASKDLPDSNIIDSLCDTEVATNKFTEFLKKLEKIGFKQKDEINNEKEKNDETLENMDSQRFKPLTHGKCMLWYLFILKILILLLKHKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU99</accession>
    <name>A0A4Q9LU99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0986p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000986">
        <property type="protein sequence ID" value="TBU11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0986p0010"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1102" mass="129022" checksum="C2D6361106AFAAED" modified="2019-07-31" version="1">MPRINKISRYCKPDKKRKIENETEKHHFSEYQGSIKLITLLILFRSLFKPCNCFRIEVMFPNEEGKRQSIRNDSTSYVFEPIGENQLIPSTSNQAFSNTTKNTNYIQEVNIVDIDQEFDKNKKTEHTRKRKFDDNILPSGSCLSAEIHSDFDDSQPLDLSCKKKFKSSQIIEDKDSEWIKKSNTSISFDYSDKFIIQSRYFNNFRESKPDDHKFNISEIASTNIDIQTFEIFLYVLHFGYHKKCLDLKTKNFINFLEAFTYLSCYTNSSVMYTLYKNLTPLLVSYMNYVKLKLPDETVKNTLFKNSMLFLPFLSTIFRTVDVKFDKNTDELLFSKKSNQFEIFFFDTKTIQKLIIRATFDALILITNEPNIDTELFSWLIHLYIINTVKISHDNIYYSEAYENDKNYISKKLPSGEVHSNLNIFFFDVLKDILLTNRYDTRFLELERIALSSYDWNVFTSFGNLESLSLVNCIWPTNIHFFSKLYFNFPRLRILKLVGLKLNEIFFNNLIKIKIEYLDLIDCYYKCRNDKLIIWDDDNTLRGLRIDYSKLGYECTNFLIKSKNLEYISLRHIKFPCNKSGSFLLGRKNFNSLELSGFNLLEYISNFFYADIEFENLSLTDMSSIDLKCILKQKTLHKSTKSLDLSGCPLDSVEIDFLKQFEKLEALKLRNLPSLEQSLTDLDFSFKNTLISIDLSNSKFLQKDLAFLCQFNCLKELKIANCDFKPGFMRFIKFGFSCSSLQKLDISENQLDIHDIYSLSLLKNLNYLSITVDDRIYMQFVARYGNISFSKLSTLVLLSTSTTKIPMQFITAQLSLINLHFINLTINDGILSYLHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLKEISTIRAAISKVENNNRTHLALIKGFLKVKYRLVEKVPNKSLEEAQLAKLYNEIEKRKIHSKLYNARKNELVSVSDSSIWLKRGNTRPRNEAVSCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNELVRYLHLLLLNRYKFKSSKQIRSHSVQEILDNEYAEIRVDTRIKTDITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC4</accession>
    <name>A0A4Q9LUC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0829p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000829">
        <property type="protein sequence ID" value="TBU12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0829p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17658" checksum="BC803B9DD343B2E6" modified="2019-07-31" version="1">MKFLYAQACAFKLKESDFITTDVKNRILRIGNAYYITNYDKLLPQIRDNRLILEVLFNLFTIQVIHLQNIDRIRSEVENILSLVLNKLEKIVFFNLKLDNIFIDFINKHKLFRRTKALEFIACDFKDIVFIYLKKLKIYLGFHSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI6</accession>
    <name>A0A4Q9LUI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0843p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000843">
        <property type="protein sequence ID" value="TBU12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0843p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124975" checksum="8F8ABE795E5B2DB7" modified="2019-07-31" version="1">MDVEWKNLNIELKNKNKSIAKKYVKLVKNAYGEAKAGELCAIMGPSGSGKTTLLKALAGRIPDGGKTTGIVTSNKLERRNRDWINNIAFVDQDDCCYENLTVRQTITYAAKFRLKDKSVKINDKVDTIISNLYLKKIANTRIKSISGGERKRTMIGVELVTDPKIILLDEPTSGLDSSYALDLIRLFKEIAEKKLVTIIFTIHQPSYEIFLLFNRLVLLFDGNTVYNSTANEFKTKAESFGFLKREFCSEPEFAIDILKFREEYNEIPENLTNVNEMIKQTLENQEEFKITQPSTSNMFYNGFFPNFYHIFVLLERRFRLYFLGKKGLKYLLYFLCSMILFSLFNVESIYYKWRIFGVNALMNALIQIDETKKINFTWFLKDNSEPLIKKEFQRIIITLLMINAQLVFSSIFNGSVSHSFVEERDRVKREIGVQSYTTISYFTSIFLYHIFLNVLSSILFIVIFKIHFGDFLYNDFYLFSSLSFFGLLPLLLLYGTMANNTAFASILNIVMAICTTVSPQILALIHFYLKEKVKFKGIKVFRMFVFFPFYDLRYIFSIKFFDSIDTNIFSDSKHLPFLQTTLSDLKYILGNFFEIEDISVGFMSGVFFLMTASIIFISIILLNQFLRPEMPKLCATPCDKFPPSSSYTKTTQLPPILTCIKMQNCRFDTLPSPNTPLPSSVEVSTCNPSYDMAKPCTIAIPDGKASNCFFALHMYYNEKFSCAVLFDVLKKLEKIIGQTRKNPNELVEFKVSELINRSITDAAHIVQAAQVCHDEAILTTQTDTVFNSNNKLLFIDNHKLFALDVQTFEEMTEKFSKEKKCIYAQDIKNIYSFHIKNFEEHNLELLELPGKHKDSSTRSVAILKLRKKWEEAQSDKLYKEIKKRKLHSKLDDAKNNELIAKKGSVRLHDEAVFCYIKDRNSFWSAEGMSTRFAKMLVQEILDNEYADPKVEIGIKTELGLVYRFNVKDNSVSDDLKSFETIYIERRRGHEYRTNAEESYDVTDMNKRHTPLLKQVCNEEDGVTTKDAKNILTLIFDYIAATAKKLRINSNEESYLEKAVQGLKVRNNYLKVINLIPKNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI9</accession>
    <name>A0A4Q9LUI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1210p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001210">
        <property type="protein sequence ID" value="TBU11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1210p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="614" mass="70988" checksum="B3BA73FBC32FE867" modified="2019-07-31" version="1">MEKKTKKILFAIVGFLSLLVIVVFTLIYLNANQISKKFMKEFEDFKKSKEGATILREFNDCESISTLFTKTESNISVPPISFCIKNIESIKEIIKMIYFPTRDAVITPQAALQKCVTFFENSKIVFLPYFIEVNQLKAFMKSYEPSSFASMGLRFVKNGNAIRFLQKYIGSLEKIILNFKIPFGYLEQCISNNTVHIKSTHIPLSSPTETLKFLTENNSTVKIDFKNDKRMDFLLFFMYKSRKSNIKECFLNFTDWVVKSKGLPNILNFFVHFIITETPDFILLPITNFISSDVDTFLSSLFCLKQQMISSIEKTNDLQPILNLGISMLSSACDALWKEFYENKDNILKDLENRKPPLLILKSMFENLSNKTNIFNISNSLQIDTGIDSEYERLLEDRKEKIRKKEAVTTTSSDTIDEYIEEFLINFIKEYVPELVEKNNEPLIETEADALLKGKVNEFIGKFLTDFFKQYFPQLVQNKDEPLTKTEAVSLLEGKINECIENFLTVFIKEYVPKLVKNNKKDLDKTKAVSLLKNEIKSKLISLSGESIGNFLEFVISTLLKLYEEDINRSRKDGSDPSQENDNEIFEKQLLSALIRVLKKVVGQNWHIFTSFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK0</accession>
    <name>A0A4Q9LUK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1204p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001204">
        <property type="protein sequence ID" value="TBU11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1204p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6849" checksum="A9D63C6D5CB15E9A" modified="2019-07-31" version="1">MYKNDIPEAAIPPFRQASNPKMNLTEIYKKDLDEEELIKEVAEIYKSVQKQFKNNSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP8</accession>
    <name>A0A4Q9LUP8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0779p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0030"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20935" checksum="E76ED6B4F83F7E59" modified="2019-07-31" version="1">MDDKACLICKDDLVLPHKLPCNHIFCYICIKRHLTFRNFCPFCYKFPFHTTDLEKLDSNVVNTTLPNIKIPLFKHMNEVLLKKELKKYMLNQDGGYQQMLWRMKEFHLIYSAEKMKTKSLSLTGIARVVSKNEKIFFHKKNDHNCPQFLEKQNRSIQKLKDIIKNSKNSHTRESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT5</accession>
    <name>A0A4Q9LUT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0759p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000759">
        <property type="protein sequence ID" value="TBU12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0759p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="235" mass="28260" checksum="6A9D479D66D4BEF6" modified="2019-07-31" version="1" fragment="single">FQDEIECKSKLIKILNEKFQKKIYCEFPELEKIICFFKRRYSSDKINFKCILPILCLIQLNNSGCKKYEGHANDYFLLGGRYRIFYIVSYIQVIRDLFFSLSPTQDILPKNQNIIKSFMENFSFISSSQEIIEDSCVFELCLFIYSNVFCFVETKELNDWENEYLNLLNSINEAVYGYKIDDKVDIQELYKNIYIIFEQNLSIFKFLLRKLILFHGFRSDDPRYKIIINWAEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX8</accession>
    <name>A0A4Q9LUX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP binding subunit of chaperone protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0916p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000916">
        <property type="protein sequence ID" value="TBU12056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0916p0010"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="169"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="569"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="8">
        <location>
            <begin position="735"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="411"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="838" mass="93891" checksum="AB9F2A155C5F57E2" modified="2019-07-31" version="1">MQKNYDQETKKLLDSAFTLAYENNNSTVEPEHLLRVILEEKQTTLKPEDKRIISEILLTKIHAFPKQQDAPVPNIGTSLLKVIMESEKIATTRNESVTPTHLLSSLLEIPKIKTIFTSKNIELPSLVKSDALSQFSVDMIEQARQNLLDPVIGRDEEIRLVMEILAKKTKSNPILVGNPGVGKTAIVSGLAQLIAKNKVPTLANAKIYNIDVGAMVAGTSLRGAFEERLKKVIKEAEKSPNIILFIDEIHIVLSAGSTGESAMDAANMLKPSLASGAIKCIGATTFEEYRKYIEKDPAFARRFVQVTVKEPNIEDTVTMLRGMRERMELHHGIKISDDALVFAAKCAKKYIPRRHLPDSAIDLIDTACASMVIDLEGEPQELLNIKGKIWSAELEKAALELDLGRIKNQQDNIIEERLKETETKIQRLNNELKPLEENFYKGKGRILEIKKIKKRIDDLNSKLSNAERDRDIYTVVDIQQNILPILKEKLEKLEKESIIGEIIGPNNVAEVLSRWVGINVGRITLKENERLLNMGDRIKSRIFGQDTAVDTVVRCLLQNRVGLSVPNKPIGTFLFLGPTGVGKTELAKALSYELFDDEKNMVCIDMSEYGNEMSVSKLVGVSAGYVGYGEGGVLTEAVRNKPYNVVLLDEVDLAHSRALNLLYQILDEGRVMDGKGVVVDFTNTVIIMTSNIGQNEILSSKNVEEVKGIVENKIVEKFGMALFNRMDGVVYFNVLTIEVMSKIFDYNLNQMNKRLKEKKLMLKVSDRVKDDVLARCFNQFYGARPLKRYMQKNFMDGVTRLILSHGSEIEKGIISCYCDDEGIIGEIVGDYVYVLNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUY5</accession>
    <name>A0A4Q9LUY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0913p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000913">
        <property type="protein sequence ID" value="TBU12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0913p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="49702" checksum="F0A72469CAB36290" modified="2019-07-31" version="1">MDKNTKDNEKEKKLKPKNQSESLVENKNTIIFNKDNTEIILDKEKGLHKDGHKKQYNDISDTFETTELIPNNKVNTNYNQSANVPEASDLLCKEKLILNNKPFDNLSDNLEANIFQNRYKNKYKILFDIENIKKILFLENDKYFFCNDYTVFYKIDQNLMKYEFVNKIFTIYFDNKNIFVITETCKIIVFNVEEERVLCIESGIGKKLHLSKRFHRKIYFVFDDGTLYSVTFDDIKMVKIQFENRKIQNNTFYLDSRNGENDSSDSTDKSDISFEYELESDNSILGKNIFVKNVFVNNNIYISDLFGNVYILENEITFLYSHFSDVQCMKGNDKILLTYSENFLVSIYDIENNKIMYKNKFDVPIFIINLEYYVKEYTICNFSDQEIQKDLPKYNFIKFNKNYFCIVTKENVLVTGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV38</accession>
    <name>A0A4Q9LV38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0718p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000718">
        <property type="protein sequence ID" value="TBU12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0718p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="17433" checksum="832BB3C42F434D08" modified="2019-07-31" version="1" fragment="single">ELGLIYRCSVEIIPYVMTWDGIVTKYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV63</accession>
    <name>A0A4Q9LV63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0824p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000824">
        <property type="protein sequence ID" value="TBU12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0824p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="277" mass="32977" checksum="54533F3C5C3D3CB7" modified="2019-07-31" version="1">MNNLLNILITEIKESHEVPLVIEWCEEFIRNYYKNNEYFESMLVFYKKNQVKCSEKHEILNICVNLFYFGYDITNNICYNKYTDLDERSIHVVGSMVCWAAIGNILRKNFNDDLYLQLTEIFDDAGLYLNLPNNRNICLNFNMSKLRLNFYTKVYLPLKIKDALNCENNGNNYNKYENIFCFSYLNKEFRLKNLKKEELFDNFSEYLKFFSEDIDLGIIMDKIISGLYIRELELPEIKIHLKTWKNRPDIFILATKTLVDVGITSQDSLQIIKIEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI5</accession>
    <name>A0A4Q9LVI5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0661p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000661">
        <property type="protein sequence ID" value="TBU12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0661p0020"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="315"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1149" mass="135670" checksum="90E6869FE9E2DE8C" modified="2019-07-31" version="1" fragment="single">MHCSYRKGNILSLKLRNFQTYSEIKFNFGPNLNFIAGPNGSGKSSIANALVFVFGGTPKTIGKSKNISDYIKFDTVDGYVEAVIKISDEEVCTVKRTIRAHSNTSNWFKNNIPVTKIEIQSLVQSLNINVDNLCQFLPQEKVSEFSRLSPEELLQETLETSTDKIIISKKENLKLLENNLIKIENNIDVVDKRKEGIEKVMNDMKRDVEKFVEKEKMEEKIKLMKIKKEWIIFEINQKNYTEIGNKIKVLKEKIEEENENLIEINKAIEEEQNDSQFINFDGKLVDFKNRNNKLDCKIKNISSKKQTKDLIEIDKVSLEKKINSRNSELKNLTKKIEDLKNKLNKISIPKPIEINENDKNKIDELEEELSNLKREMMKIQNESVEISKEIEDLTSKRNLLTESDSRKLEQLKKYHNDTYQAVVWLRANKNIFKDEIIEPPFLHINLKDLKYSQEVEMFLNFSILSTFICKNFEDFEKLTSFLKDEKKLKINVFEKITSESKSKYTLEEIKNLGFDGYLIDFIETRNEIKEFINIMGHFNEIPIAKKSLNENAIFKTHDFKRMVINKSYFEIKRSKYNSEDFIIIQNRISSKNFFDTKLPQQEISEIEKILKSKDLKRKDNRIQYKIIMEKINEKDDFLNDLYSKRSEYKARLMEIENITEQKKYLSNNIKDLEIEFKKLSDFSKYEIEEQEIKEKIKIINIEIQNSISEVVKNVKEENFYEFFTDLYFLHQEIKQKELKILSEKQKLKEINISIEEYNDLLKKFISSKSELKSVLKKSKKEILENKLSPLQTQVLNKLPDKIENLDKEIASESAKLTFFNIDTEFIKDFTSKENILNEINLKKSNFENEKRSVQIKIDSLKNDLIIKIQEIIKPINEKFRYFFKKINCEGKIEFHEKDLFSSKWGINILVKFRENENFEILSSFRQSGGEKSVTTILFLLSLQESSPAPFRLVDEINQGMDRYNEKLVHDILLEISEQPNSPQFFIITPKIVPDLSFSRNMKVIIVYAGMFENLERIFENYKHNVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKFYSKLYNARKNELASVSDSSRWLKRGNIRSRNEAVFCYIQDRNVFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW02</accession>
    <name>A0A4Q9LW02_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1009p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001009">
        <property type="protein sequence ID" value="TBU11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1009p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41975" checksum="276014D2D022AA12" modified="2019-07-31" version="1" fragment="single">VTEEMKEKRKQRKDRKALREIEEDIKIFKELLSGDEFSDREEFVSISSENLNPFVRNYEVLKQRAERKNRILKNPKPIPLPGESTESECEISCESNSEFLSCTSGSERSKKVEKGKNIVEVVLTSPDDIKKTDNYLVRAFKKIKEKYINFCYLPAFFLKKGMCFFKDTPYDSGESTNEASEINSEFDEVNSDSSEAKIVSRRDVLNFLNRNCEDKDLRKILEKEEYFIKIKNIFKKEILRNKKISNEFFLSKLEHVFKDINNFIVNDQFYSVQETVCSSSEVTSEYESCISQFKDRIESEEISSFFCSLSTNSTNYDLKPNDNSNNEVEPVKKDNVSIYLKVSAFCTFILSLIGSGLYFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW30</accession>
    <name>A0A4Q9LW30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0118p0050</name>
        <name evidence="2" type="ORF">CWI38_0579p0030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000579">
        <property type="protein sequence ID" value="TBU12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0579p0030"/>
    <dbReference type="OrthoDB" id="2196277at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="51930" checksum="621A8B920FDC773B" modified="2019-07-31" version="1">MDTSSDDIIEIKSIKKVTNKRKIEASDIYHDKSSDSDIIFVKAEKNMTAEKKFICTDQNRVNQDNILNGNEKNENAKKEKVVSKNGTQQKDLPNTSTILEVTKETDKDKYVGSIKSNCEFDRDISAEIEECKRLVPNTSNIEEINDISAEIEEIKSLTPNISNTQDGSDISSEIDGYESPKLDILNNEGKDYKSETEDDLDSIFNLNKNTIFQQYDNSKARKKTSIEGIKNTNCTSIALNESINVHKKDGNCNVNETKEISTGYKKDTPIKNYNKLKCIDIKNYSSIILDVPDNKETIRKKEKDLTKIFIKENGNLKKYFFLSKNQTFEEIYKEIIGYDLDKKIFYKNMAVSKYSTLENICYNDCDNIFEIINVNKNENNLQEIEIKVNYDFNKTVSVQVDRNQKFKDLLQICTILCPGYNFKNVMMNGDTFDMNEIISNYLESNDVIDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW53</accession>
    <name>A0A4Q9LW53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0573p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000573">
        <property type="protein sequence ID" value="TBU12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0573p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="614" mass="70977" checksum="B3BA7034C230EAB7" modified="2019-07-31" version="1">MEKKTKKILFAIVGFLSLLVIVVFTLIYLNANQISKKFMKEFEDFKKSKEGATILREFNDCESISTLFTKTESNISVPPISFCIKNIESIKEIIKMIYFPTRDAVITPQAALQKCVTFFENSKIVFLPYFIEVNQLKAFMKSYEPSSFASMGLRFVKNGNAIRFLQKYIGSLEKIILNFKIPFGYLEQCISNNTVHIKSTHIPLSSPTETLKFLTENNSTVKIDFKNDKRMDFLLFFMYKSRKSNIKECFLNFTDWVVKSKGLPNILNFFVHFIITETPDFILLPITNFISSDVDTFLSSLFCLKQQMISSIEKTNDLQPILNLGISMLSSACDALWKEFYENKDNILKDLENRKPPLLILKSMFENLSNKTNIFNISNSLQIDTGIDSEYERLLEDRKEKIRKKEAVTTTSSDTIDEYIEEFLINFIKEYVPELVEKNNEPLIETEADALLKGKVNEFIGKFLTDFFKQYFPQLVQNKDESLTKTEAVSLLEGKINECIENFLTVFIKEYVPKLVKNNKKDLDKTKAVSLLKNEIKSKLISLSGESIGNFLEFVISTLLKLYEEDINRSRKDGSDPSQENDNEIFEKQLLSALIRVLKKVVGQNWHIFTSFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ5</accession>
    <name>A0A4Q9LWQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0876p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000876">
        <property type="protein sequence ID" value="TBU12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0876p0020"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="434" mass="51814" checksum="AAA9568BC29BEB7A" modified="2019-07-31" version="1">MLIKETNENSKKPIFKNKDPDIIWKQISRKKLIMYDQENQMQNNFLDEIRYDSEEIQFVQNTQDFSFPKYLNNSSKFYSDNCKEKSKQKIFDKNINPSALNSNNIYEMNNNIYDTNNNQRNLSKNIYESNRNISTNIYDTNNNQRNLSKNIYESNRNISTNIYDTNNQRNTSSNIYESSKNHKNTSTNPYESSKNQRNIYDTNKNQRNIFPNWYFEKYKNIENLQSNNYLFPFFKFDNSLIKTSEIFSEHLKTVDEEFYKNNFETFEVQNTNLSKYKKNGINNFSMQLSDYKIDVESINRSEDTRKTCMIKNIPNKYTQKMLIDLLNEDHYGTFDFVYLRMDFRNKCNVGYAFVNFIDYKTIPSFYNKINGKGWKKFSSNKIAELTYASIQGLENLVIKFRKSSIMNEVESFRPKLFHSCGPFKGQEKKSFDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW4</accession>
    <name>A0A4Q9LWW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0485p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000485">
        <property type="protein sequence ID" value="TBU13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0485p0040"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18294" checksum="12D589BA255C2437" modified="2019-07-31" version="1" fragment="single">RKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSPLKRLEIPMNVEAYIQSIGLKKTVETISFDRRRGLESELNAEESWERASMGVIMRAEMHEELKPYLKEEKREEDGAKNFKPKNKAPFIQGGTTLEEPTNNINLKSDLEEETAVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX49</accession>
    <name>A0A4Q9LX49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0827p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000827">
        <property type="protein sequence ID" value="TBU12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX49"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0827p0020"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF25">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="330" mass="37573" checksum="4F005FF353421AB1" modified="2019-07-31" version="1">MQITLKLNNKKITLEVDSIEMSILSVKKKFEEVLEEGSKIPAEQQKFVINGIFLDNKKTLKDYDITESSVIHVIGTRRTINVPSKKDSSIGQTNQSNISSNPPSHPNIPNIGNQPSYPSNPNIPSNDSFNDVISSQLDAFINNPSIMDQQFGSFMGNMNEEQKSAWKKVMTEQLKEIKKNPQLLRQMMSQFSGMGDPNYMAQQPYGAPYGAPMQSPYNIPQPIPQPPMQSPYNTSQPPMQSPYNIPQQYNTPTIPCSHGFYPLYFINYLSSINKKQPEITNYEEFFKEQLKLLEEMGYTNKQVNLEALKECNGDINDAIDWIIRWNSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI6</accession>
    <name>A0A4Q9LXI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0764p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000764">
        <property type="protein sequence ID" value="TBU12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0764p0030"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="191"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="384" mass="45345" checksum="3F75DF5F204D6293" modified="2019-07-31" version="1">MIGKIKNFQVVQGKFNAEKKHNKNKETPFTSSELLQLMSNLKKTSSKQQNILPVYRHLQCHIENHSQVRKECKNTNSCFQIVKKESLVFKYNINNNYLYALIENTYSRTNIDQKNKITVQNIQKNDRIQYKKPIKALEFKPENKIYYSKLSNDEKESLKKYCRYMLREKPKKSSGCIINMIKGFFMGKKRSEVANKKDINPFIYNVGNYILKEGIKTEGIFRISGRSSLYKSVPYSLKENCGYKTSEYTIHDNASIFKAYIRDVLNGLVPEFICKELLETFKGSRNAKSIEEIVIYTIFCLDDMERELLLYLRRMFREIENYKDYNKMTMENLVKIFTPTLFPDFKPFDLTMIDKQIDFIKLLFESDFEEVPIDLLNAAHPNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR5</accession>
    <name>A0A4Q9LXR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0731p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000731">
        <property type="protein sequence ID" value="TBU12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0731p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12605" checksum="09C5C0D336833DC1" modified="2019-07-31" version="1">MQRNWSLFTEKFSKIKKIDYDSPLVSFFPGIIMLKDFIYKLLLEKVLQDRNIFNIFVGMKMIESLLFSSKEKISSFCNENSLDIFSYRHGVKNIINVHKKMFFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY40</accession>
    <name>A0A4Q9LY40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0368p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000368">
        <property type="protein sequence ID" value="TBU13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0368p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20895" checksum="02B0F6A198450EDA" modified="2019-07-31" version="1">MRKDYQDVAFYGMPYFFEMKRLKTFFSKYNADIFTRIGLFFNKNKKIIEFLAKYVKILEKSISRQTDDIGMGWLRQSFDNTSVKFYTGNLSGKSLDSIDNSLFRMQGIPETVIRFENKDKLNIVMFLFYKSHKVNFDENDLILFDDAYTTGGDKYIEALEPRLKYFHMSAENEDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYD7</accession>
    <name>A0A4Q9LYD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0648p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000648">
        <property type="protein sequence ID" value="TBU12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYD7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0648p0040"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF827">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="262" mass="30726" checksum="37216D888DB55B0E" modified="2019-07-31" version="1">MEDKILFLNMEKHENIEFSIFGIFDGHGGYEVAEYCKENFIKFLKKEISNVTRNNLHVYNWESIFKKTFIEIDNSLLKEKYIYSFTGTTALLLFINHNKPMNEFYIINLGDSTAFKCNETRYTVLNEHHNLRNSVEATRLRNTNINIFGGRLDGKLDVTRSLGDFYFKKNENRNLDSCDKELSPVPECLRIKFAKEEVLSIMSDGVTDGIDFPSLHKIIIQYSFEKNQLNFLPKRIFEVCLMENPDKQRSEDNMSIIIIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG9</accession>
    <name>A0A4Q9LYG9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0569p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000569">
        <property type="protein sequence ID" value="TBU12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0569p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="289" mass="33776" checksum="51372C73E54C9036" modified="2019-07-31" version="1">MLLQLLDCLEKSKEILTRRSAILKVENTNKTHLPLIKGIIKVKYKLEESVTKRNLEEAQLAKLYNEIERKITFKLVNIIAPSKWLKKGKIMPHNESVFCYIQDRNFSGDHKVSTRCKKMLGHNLIQCLHLLLLNRYKFKSSKQIRSHSVQEFFIMSDKNDVKIRLGITSQDSLQIVEIETLRKSYLLFILEIIPYVMTWDSIMTKYHRTYTVETISFDRRRGLESRPNAEQSWKRASLIGANQINSINIISLILDGLTTVKEPTININKKSDLEEDNEVVKRAEKMIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP2</accession>
    <name>A0A4Q9LYP2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0305p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000305">
        <property type="protein sequence ID" value="TBU15840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0305p0010"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU15840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14780" checksum="E76B4F0E691DB526" modified="2019-07-31" version="1" fragment="single">MPKKIKVCIRIRNTYDDSVWEINNTILYQKIDCNKRLAFDCFQGLFFRHTNLNIFDECLIELLDEFLSGINCTVFAYGQTGSGKTHTMLGTEMENGLIKLSLVYLIQKTTSKQLKASYIEIYNEKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR4</accession>
    <name>A0A4Q9LYR4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0275p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000275">
        <property type="protein sequence ID" value="TBU17647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0275p0030"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU17647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="11499" checksum="002AD745DCC705F0" modified="2019-07-31" version="1">MPSDFDTKKVVLTKKIPSKPKEIKEEGETEKDFVGKEIGRIIAVKREEKKMTQKQLATRISKPSSLVSEWEHGIAVYDDKIADKFEKVLGIKIKRSNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ6</accession>
    <name>A0A4Q9LYZ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0558p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000558">
        <property type="protein sequence ID" value="TBU13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0558p0030"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="92836" checksum="1FD85AA2A288BF53" modified="2019-07-31" version="1">MVDSTNSFNPTNINNSKESFQAESFISPHNRCSSSATPNCSSEDIQHKEYDSNKRRRLDDANKTENTQCHFTGQTSHTTNDVCTGGVINQNSPAIFSFWNRNTIENAIKFPGDIQIVLPLEPINIVRFDYSENYMIRSMYLDEFNNVKTSKKEINIQDITNSNIDSSLFEECIYVLRYGWNCNFLGIKKENFLNLISLIYDLKCYSNSDALLTLYKSLLTYIFVYLENRSFNDTFDLTKDDFITHKKHFLPFIYVLYDSIKVTYDLDNKELTFIEKKNVKKEISIQYHDVDEIIIRITPRALELIDQERHTNKSTILNCIISVYKTKGIKISSDNSFFYESKNSDSVRTSAINKLQIENMNTSFIFLFNSMKFIERREVISIEFERIVVSKIDMFFLGRLIYLKTLTLVQCTFKNFKAFYRAVSSKFPELQNLRFVGLNLLTGFLNNLCYMKIEILELLFCNFTVDLRSFKPRELIKLKKFKMNYTSIKFRIIESMMLSKTLEVLSLKGVAFTNYKYPECFENWQKYFRSLDLSYCKLCYTSLKFFSENIKAEKLYLNYFQIESQIVNILNQKSLHISTRKLSLCGNRIDSKLFYIITHFEVLEYLNLSSLKENSYNFYMSEHKFYSKLVDLNLSGNKIKEISFGFAKQLDRLVGLNLFNCNLKPGSLSDFCLGFMNTSLKRINLAGNVLHLSDIIQIGLLINLENFVLSLDNKVFSEFIEKYSALSFQNLETLILILTNLDDAIINFIISQPSLKSIELRNCTIRDKHQIDCKLTPDGFKRRISEDSEITIIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZZ0</accession>
    <name>A0A4Q9LZZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNF2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0412p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000412">
        <property type="protein sequence ID" value="TBU13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LZZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0412p0020"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003398">
        <property type="entry name" value="Mot1 helicase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2613"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2641"/>
            <end position="2666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2678"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2706"/>
            <end position="2728"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="2055"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="2412"/>
            <end position="2577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1487"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1788"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1990"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2212"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2330"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="787"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1347"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1510"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1788"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1805"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1828"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1861"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1878"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1993"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2028"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2266"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2330"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2346"/>
            <end position="2365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2729" mass="307651" checksum="88BC4BA7E2F48272" modified="2019-07-31" version="1">MNQLEKIFSNILSSTNKYHKKLLITDLTLQIKEYLDFTTPLLQTTYTLLTSEVWDDRILGATLLGSLYPSHIKYKIDFKDLPSFSLHSHSFFSTRITSYTECSVSFQEQQNLITKKLGLTPFEPDNSLITKKDVITEEIKIDNKRGVSKEARKRGVSKDNNYRGVNKDLDSYRGVNKDIDSYRGVNNSTYKQQGVNNCTYKQQGVINSTYKQQGVNNLSNEQQGVNNTPSNTISNTPPILSKREELAQKRKNKLSYEKEENETEEVKIQNTNHFFIKLYENLLSVEWTKRHGAFLGFCSIFMQLKMTPLNLYNEMHKQNKYKYNQTPEKHKNKEIVEEEEEEINKNSNISNKDNTKDNISNKDNISNNINNKEINTLDHDIDNTHSNNTILLNSTLISSILQILYHDKFNDFISDKTTAPVRESSAHLLSLIFPFLSIKLQNYIFKILFSFLENTDWQIQCSALNSLILLKEFIIYNKNTNNSVFINKMVCLMKSEDEDVKYLSADLIIPFIDMLCKIKGDKDNSRLEGVSDIKGVGGVSNSRVELEGVSRTTDEQHPLNNTSYEQHPLDYLPGEQHPLNNTLYEQHPLSNNTGEQHPVNNNIEQHPFNNLSNTYNTSIDSSINNSIDTPFISITTLKDNTLLTNISYTCWISLQNENEIALSKTSILRLITEIYKLGILKHFDLNKITPCFRSPLIDVRSSVISMMECIIKGVKYSGSKKEGVNYSGSEVEGVNDSVIELEGVSNTNSKEEGVNDKSSKKEGVNDRVGVQEGVNEIIVEQEGVNHYTNTYNPNNSTSNYNPNNNTSNYHPVNNTANDTNDNTNTYNPNNNTSNYHPVNNIPNDTNDKDLLHLYPINNTLLSRDSLITIFKLLIHNILIEDNTSLKERSFLLFKLLLNNNNWLSKYLKPFIIGIGQSCYDYYTFYSYESNSLYFNSGIIIIGRESVMDGKVMLLKGVIGCKGIEKIEEEGDLYRRVIIRVYNEIGEVSMLRGYNNKWLEGDNKSIDSKQQGVTNINTKQQGDNNIDKQQGVNGIHTKQQGVNSIDKQQGVNGIHTKQQGVNNIDSKQQGVNNSIDKQHPFNNLHYEQHPFNNLHYEQHPFNNVHYEQHPVNITTLPDNILSLFTPFNLPVNLILKKINTPLKCTTLEMDSIFIEYIRLTCLTYYNTNDLLLLHRIDWSSSFCELITQLYKLKGVNLLEISYSIYRVILEGKKEGVSNGISFFKVNKDILNSDVFIRGVNYTGSNYRGVSNNIEQGVSNSIEEGVSNNIEEGVSCIEDKYNFYGKVIQFCDLKKVEFIFYEILRNNTLYYNGSVVGDKGIVGGVSSTNNSHNKQEGVNNHNNKQEGVNNHNNKQEGVNNNNNTKGVNNNTDNTSNIKGVSNKKSNVKNPLNNSSCLEGVNDIFDINNNNDKTPFNNSINTILTHFISNNRSYLEDFISFMLEDLNPIQLYPLIDLISIEYLCMLVKPLLRIINGSNIKGISDSNRLEGVSDTSRLEGVNDSSRIEGVNDTSRIEGVNDKGNKLEGVSDKGSNYKGVSDQGNNYEGVSNKDYGLEGVNDKGSNYKGVSDKGSNYKGVSAKGNNYEGVSNSKDSREGISNNTNIYKGVNTTTSKQDPVSNSTNTLHPLTTSDYRNYALMCFSKIIPLLVISIDINKVSNTFKQRVLENKRDIDELIFNKEITPYKIEVPINVVLRDYQLKGIQWIAFMCKYSCNGVLADDMGLGKTIQVLTYIANEIYKYKKVKGVNDKGMVEDMVEGNDTKVGNVKDMVEGNDTKVGMVKDMVKDMVEGVNESKEGNVKGVKDKGSKQQGVNNSSSNIKGVNKPSDKQHPLSNTPDKQHPLSNTPDKQHPLSNTIGNLNGVIKKTKIKPVKSKNTKQKRSNPISSNTSSISSNVNPIDSNIVVSSSNTSSTTSSTITNNITTTNPNTITTTNPNPNPNPNIITTTNPDFITTTNNNITNNNYKVLVICPSSLTGHWLSEVNNIFPTLTASLYSKGDSRDSNKGDSKLSGSSKDKDSNKVSKDKDNKDNRNPTTTNPTTTNPTTTTTTTTTTTTTPSDITILSYDAYRNDYLNISKTTFYFIILDEGHLLRNRDTVIYKRILLLKSTYKIILTGTPIQNTIEDIFSLFNILMPCYLGTEKEFNNKFKNINYKEKSEEEYFKMEKCIEELHKKILPFVLRRMKSDVLKDLPPKVIRDIVIEMSEYQREVYKGIEMGDLEGDMGEGDRLEMGEGDSELEGDRLEMGELEGDSYSIDDYRGVSNKSTKEEGVSNNSSKQQGVSYKSIKQQGVINSIDKQQGVSYSIHKQQGVSNKSSKQQGVSYSIDKQQGVNNLSNKQQGVNNLSNKQGVNTYTTTNTYTTKHTKQTNTSKKLKLSYSSVDKKSNTFLKLSKLLKVCSHLSLIGINTSYTNSCKMKALEDLLNLCGNTDMRNKVLIFCQLRNTIDLIIKDLLLINYKNMYCRLDGSVNIKDRNKTVEEFNKGSKSIMLLTTSVGGLGLNLTSADTVIFYEHDWNPFNDLQAMDRAHRIGQKKTVNVFRLVVKDTVEERVMNLQAFKIHVAGSLISQQNTDIERMETCGDSLISQQNTDIERMETCGLLERFGLYTGNRVLFKNVILKGVIYSIVAIISYKGVIYSIVLIISYKGVIYSIVAIISYKGVIYSIVVIISYKGVIYSIVAIISYKGVIYSIVLIISYKGVIYSIVAIISYKGVIYSIVAIISYKGVIYSIVLIISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M022</accession>
    <name>A0A4Q9M022_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0164p0020</name>
        <name evidence="2" type="ORF">CWI38_0585p0020</name>
        <name evidence="1" type="ORF">CWI38_0618p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000618">
        <property type="protein sequence ID" value="TBU12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000585">
        <property type="protein sequence ID" value="TBU12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000164">
        <property type="protein sequence ID" value="TBU19954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M022"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0164p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0585p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0618p0020"/>
    <dbReference type="OrthoDB" id="2200790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="22161" checksum="B11896DCF3C903B9" modified="2019-07-31" version="1">MLLFLLYFYLNDCIFVKFNFIVNEKVYISLNKSYGDYPGEIIGITDTWQSVLTNYCNVAEMRHIDENVYDIFFCGFKLCYDEENNILQGCIGDEYLTKWRLDELNEKEKVYRLRNNGHCINLSGNSILHMSSCDKNYKPNELLKMKIYLPPSPFEKNFGGSQAFNNSLFVYNMSNTENLHRLRSLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M030</accession>
    <name>A0A4Q9M030_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exportin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0436p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000436">
        <property type="protein sequence ID" value="TBU13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M030"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0436p0040"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1045" mass="122637" checksum="F86B764B6110293E" modified="2019-07-31" version="1">MESILNFSEDLDVNLFDSIVKTALDSSSSEKSKAETVLVKFKEHPNAWTRVDYILTTSSYTPSHFVALQVLETQVKTKWVLFTEEQRNGLKSYVVQSVIKRSEQQDQIILNRFDIILVEILKKDWPRNWPTFISDLITASQNSSMEVCRNSLEILKRLNEEIFMFGEGNITTVRKRMLQNQLKNEFIHIFQLIKTILEYSKKMNITDKLLDTTLSTLQSFSKWMPLQFIVDTEIVELVVSFINTSHSIACLKCLYEIVKRMVNEKVEISSQESKTVDEKILLINFSLIEFLNLYFSKFGSEKLSALYFNLDRMEQDFILSASFLLSLIYSNKMDLLENKSLKEFLKGLEYLIRITEIEDKKIFVSVLECWSSFVFCLYNEYPYFATSRVSLRRDKYTSILEMLIQALVDKMPRPEEVLVIENEYGEIVKEKLTETEAIDFYKEMKRTIFHLSSLTGERIKSFFIKKLDKQLDGSEWEIKKLNKICWSIGCVSESFSKDEESLFFVDVLKNLLALCEMKVSKDDKAVIASNIMYLVGQYHRFLVSNKRFLKTVVKKLFEFMDETHEGIQDMACDTLLRITNKCPHEFLIQREENDVYISYILKNLCRITKSLEFYQKRIIYECMCVVLQGMNTEMTKKSGVSMNNVEYYKKLEYINLLTSSFSDTNIFQEKIQEKLSELIINRDFVRIVSHVLKSFSLVYKNLPESIITSFQNVFPFLFSMYERLDLIKNGQINSLANKNIILAKQEIIEVFTNVVSVLENLNDKFITKEMKSNFLNNLFQKIIFDYKKSFKDHTLLLLGGECFKSIDFSGEEDAFKSEVFILNTLIEPSIPLILKSEENNDIQTAYYRLLDILIIKRFDSFFPLIFSNSDTFNSIFDSLLYGFICRREISELCLSTILTTFKKCYEINNFLFFQKYFLNTMTNILGIIFDKDKDYGFELQCQILSFLLKICDKLPLFDQTVNNNTFIRNHINELFASTLKNITGESLEIFIVGMFELCRDDDIFREHVFDFRVKVYEYGCNDDLNMEIELVNERKQRIPAGKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M034</accession>
    <name>A0A4Q9M034_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0292p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000292">
        <property type="protein sequence ID" value="TBU17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M034"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0292p0040"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12779" checksum="F594A9F13DEC5FA3" modified="2019-07-31" version="1">MDTNSNLQNDLRVIQFKSLFNYVCVIRVDTGIKTDVKIRNNRLDIFILDRRQKRITLIEIRISSQDSLQILEKKEPRENDIVTKYHKTYQKRLHILMNVEAYISSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R5</accession>
    <name>A0A4Q9M0R5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0380p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000380">
        <property type="protein sequence ID" value="TBU13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0380p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020469863" evidence="1">
        <location>
            <begin position="16"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="529" mass="62568" checksum="76D3D04ED96EF4D6" modified="2019-07-31" version="1">MQLFLAITLLTISQSSNIPVRTIKKVVDYENVSKISNFNIPDIKNNKKNKVNNEANGYINASNVIVRKRTRIKWPIHKRERPVSYKHSTRQTFDSSFSIKKARIRTEKYSKIKDVRSYSVGKIDGPFSNKNERKFGFNDDKQHEYFLSKISEILEKNKIFELDSMMHCSEEFLTNGDLKNQNLKTIVFWLVTLSKRPALVAKNTSLIKFEAMIMSMSAEKTLYSCLTFLKEKLSRVSKFDSYNEIESEMPLAEINIVTAMYLIEIFLKYFNDKIYHFFPQFAIVMNFIFNSKNSSNLLNLDSMLPTFLLMIIAENTYKELQIISKDTKDILYSNFYFERLLILNYLIREIFCSLNNISYKVKPENFKRIAEFMEHINFFNENKNKLRQNPISEEYTLFTYYNFYYSMLFLYIQNKETKNSALELPLFNIIGRLNHVFNVIRKKNTLNYSMILNDIEEKSVYLIKLDAFKITSRGNFGSKPIFYALSLLSQFFDPSDEITVLDRINRFNELFASHFELETDRTNRMLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W2</accession>
    <name>A0A4Q9M0W2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit of U2 snRNP spliceosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0108p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000108">
        <property type="protein sequence ID" value="TBU20235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0W2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0108p0060"/>
    <dbReference type="OrthoDB" id="2196406at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="917" mass="108922" checksum="6CDC6E1E7087B2E9" modified="2019-07-31" version="1">MKNGKSEFLIKVKKKDTKSEWEDEVEEVGVVEKISQTPRTTTQTKRMMWDQTPVGRIKNGNFDTICSYGLSSKWDLKPNSDKFFIKENVEFNLKEIIKIVPRDIFKVLEPPLWYLDNKKEENFITDLELPCYKAEDYQLFNQLILNIGSESFEIEILKNLICLKNGEKKEVKNAKKKLLKIYGKNKFLYEKITSILISSLLNDIEKLKYLEFLKILIEYSDECFFLKDFMIIMATFILGKYFRLHKICIEIFYLIFKKHDHNFVLLIFEDEIKCKNEIYTKNISFIIYLMINFYDLKSLTLFFKSLNKSKYSKANELLAEIFVQYTLKHRNIDFKFLVKVILKLLKKENEFLKVKGCEILNLAIYKSTDSDIFLDIIDYIFRECHNVSTKVFVNYLNVLATFREKFEIENFKIEIFFRINKLIYKRFYFEKCLEIYRKICLIIEKEDSFYFLQKHFKLILTTKKIKNLQLLLEKVLKNPKNINIVFEMYRNESEVLRNLISKVIVKIDDLYIVDVQMNDYFDCLNFSLSKNDIFTIKNLEILIKKSNYQYVWIKKFFEIFISEFIQRDYQIKIYGTQKVSKIIAFLEKDDILLLYSLLIENLKDENSEIFLESILNCLLKICQRKIQNTKELVLNLTILIKNRNKNVQENILKILKFLCKEESNECENIHSKEWLRIVYGIIDILDSPSKNIRVLASECIGYISINIGPQDILNILMNSLKTLDRNQRNTTCLAISILADYCGLFTVLPTLLTDYSIPESIIQHGILKSISMIFARVNIKGRDYIPCLINIIEDSLSEKDIVHRQLGMICVKSIVLSCKSPNINQDLLIHLFNYVFPNIFETSVYLEDIFFQCMEVFCLKMDPLILIQYLVQGLFHPAKRVRNKYFKILEMVEKYRPDSFITAFSYDEDAFLNFEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W8</accession>
    <name>A0A4Q9M0W8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Noc2p-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_2476p0010</name>
        <name evidence="5" type="ORF">CWI38_0320p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002476">
        <property type="protein sequence ID" value="TBT97137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000320">
        <property type="protein sequence ID" value="TBU14827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0W8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2476p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0320p0030"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT97137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU14827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="241" mass="28251" checksum="060E52425088020C" modified="2019-07-31" version="1">MSLTIKQIYESNNIEENIVKYKKDISISKLKEEIMYLQSEEIKRENLFLFVFYCEILCDLVKNKNLIREFVDTIITMIECKTKIKNCIFRIRLINVLLKCGVFSGICDLVFKTIKTITNCKISNNLDKKRTFTLDDIKVGNDTAQSPEYKDYVIRECVNSLTKAFNLISNTMGFPEISKIVIENIKNNKYDEDILIKEFSQKLESHSQYIKKLRKEYEGKAVSIKDLEDFEKKCKTLLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Y4</accession>
    <name>A0A4Q9M0Y4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0189p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000189">
        <property type="protein sequence ID" value="TBU19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Y4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0189p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="510" mass="59299" checksum="BE63474814558019" modified="2019-07-31" version="1">MSHCESDSEESPTKNTSENSKECIFNNEFKNILNNLFETYSIYIQAIVDLQSGNNHEPRYISKNELIEILISIAEFKLLCFKELHFLEPITKYELNFCVNINCKTQCSSQDLQSIYNVFNERELMYTEMLFRFNKLAIEMNKCELCKFLNRTISENLEFQSVNITLIEVGITSQYSIQIVETKKLRKYDLLAKYLGLIYKCSVEIIPYVMTWDEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMTAEMHGEPTPSLKEEKREEDGAKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETKVVKESSKRIRSHSLQEIRDKEYAEISVNTGIKTDLKICCNRIDIYIFDKRQNNITLIDVGITPQDSLQIVKTEKPRKYDLLENGKGLIYKCSVEIIPYLMTWDGIVTKYHKHMLKESQIPINLETYILSIPLEKRDLSLAQMLKWLRERIITSDEYGETGDKNKKSVGFRQDDEVIEMVEEIIYSTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M138</accession>
    <name>A0A4Q9M138_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0256p0020</name>
        <name evidence="7" type="ORF">CWI38_0077p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01000256">
        <property type="protein sequence ID" value="TBU03664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M138"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M138"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0256p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU03664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="197" mass="23050" checksum="906346C763C1DE5E" modified="2019-07-31" version="1">MREKIFYFALGVLFSYGAFYSKHSPLSHVFAMEAFLFFIFQLYGDKIKKHPLFVPMPFDINEYKFLLGYIASEYLFFSYFIPKFRYNIIQKSGAILLLIGFGLMLYIIYSLAFECNKMLYGGLYAHARHPFYVAAFLHLVGTLLYLGNTTSPVVVLYVLKNKFAHQLEEEEGVLLDRHSSYKEYKNNTPSGFFYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M174</accession>
    <name>A0A4Q9M174_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0214p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M174"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="24370" checksum="A006460D62ECC9A8" modified="2019-07-31" version="1" fragment="single">VSEEEEQEVSEEEEEEGKEEEEEGKEEEGKDKEKLIEEVSKGESKGEKKEEEGEEEEEQEVLEEEEQEVSEEEEQEVSEEEEEEREEEEREEEEREEEEGKDKEKLIEEVSKGESKGEEKEEEGEEEEEQEVSEEEEQEVSEEEGEEEEGEEEQEVSEEEQEEGEEEQEEGEEEQENKLTKCFHSVELRSEHIILKYINFYNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D5</accession>
    <name>A0A4Q9M1D5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0301p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000301">
        <property type="protein sequence ID" value="TBU15976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0301p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="753" mass="88935" checksum="38AD5C561671F8FB" modified="2019-07-31" version="1">MMCEAILKANNIKTNFTFWSLCILSISEVILTQKTIAINFYETKEIQLTENGTKNCDYFDEFSYFDDQKPVLYSLDSNSKVLQVFIINLETFFLNFSNEEEIQENQQHNIYININILSYNEFLYFYNIVMCFPFLIENVNEIRYQLMLKICDILKIKTNKLFEKFILISTSKSYRCSGIISKKAIVEFFKIYFISEKTQKKIKDISRALYLTADFSFDFIKLTDDFLYLDDDILNEILEKVKKSNDDLKIFDYIFCIHEFTCIFLSEISYTDVYDQLFDSSLFKNLNEIFINRCLNADVLIQKIYNSCGSKCIKTLNIIESDFTMKYEIPWLRKLDFEAVNYIVGNYGRLAIFYNSDASPLVQNIFSRFIDEIYEENKPNIFVRTSEVSCYDQDKKFFVQFYQERSKLENFTTPNSPIQTYIYTELINAFLSFNFYIINFSELKNIKIHLSNTCIKDFNIRESEILNNISTVSIVDSTLDAIFLSKILMLLSLKYVIFMKCIVTFHKNVIDFNVNRKIVKLYFGNSSIDDQNHFFKFINHMVGLKILDIHSSSCCKNSNIFAFKTDSSTLDFSNLKSLRYHVFYFNKDIKPVFPKFLQLLQFDFGVNYPKGTLNKIFYNNNFSCLEKLNIYGSYIGKKDELAFENYINLLSLCFFGYSECSEMNFCKLFNSNNIYSLKKLKLPDIEITCLDLEFLSKLKCLKNIYIYSLAPQVNIFYFITSLLFVQKIEIAKKSNYINEIYEEFGKKLKSNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E4</accession>
    <name>A0A4Q9M1E4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0201p0030</name>
        <name evidence="10" type="ORF">CWI38_0201p0060</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1E4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0060"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="8">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="22861" checksum="8CA441FC0CBBFB36" modified="2019-07-31" version="1">MTHFMVGKFIVVEGIDKSGKTTVALKVKEYLQKYKKSIHCMSFPERTTEIGKILNKFLSKKIKLPNETVHLLFSANRWEFAKEISEKRKDQIILCDRYYLSGLSYSIVNGLDEEWCEFSDKGLPKPDLTIFIDIKPTQVVCRKGFGEEIYECSEYQKKVYEVLKINVLKSKEFMIIDGNLSIEEIVENISLSILNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M200</accession>
    <name>A0A4Q9M200_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0118p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0020"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="62517" checksum="911B02F763012C64" modified="2019-07-31" version="1">MGGDLDQINVEKSSFEVRNETIKNLRNLKTTQSRPFQRTMDSITIDYSNIFIIRSHCFDILYRSKLHETNINIKDITKSNIDCFWVKKCICILYYGFDSQIDGLNNNEFIDLIEFLNDLNCYSNTDALYILYKNLLPYLCLYIVNENCFNLLNMTNSEYLRHVKLFLPFLTVLYDEVDVFFNSNTKELKSFKYEMNFTDDTIIRITPEALNYMQQDDSNEKIELFGLLVSSYIITGIKISNGDKYYIECVSTDFACKFILNNPVIYKMQTSFCSLFGKIESMKINTLKSIEIERLDLLTEDVDLFSKFRKLESLSIVKCDFINYGDFLRKLALMFPKLKILRIVGLESLYSSTRTISLSNNSSFNDIFLLLENFKKLECLKLSGTKIMRLHQFVFDFQFKSHLKDLDLSNNKLSKNYIRCLNQFDCLERINLSNCNLESGFMEYLSVMHPAVSLRKINLSRNILSKSDIFALEQFINLDHLTVCFQSEIFSYFLKEYGSLRLKNLETLILVAYFFYKRNLSLHDENVFIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M292</accession>
    <name>A0A4Q9M292_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0230p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000230">
        <property type="protein sequence ID" value="TBU18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M292"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0230p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="424" mass="50714" checksum="FAD65B3F15E8FF94" modified="2019-07-31" version="1">MLYTECIALFTDEMYDVCLYLDIFNEKTLLRIKDMLLQIQPGLEDLYFINQLKNLKKWDSKKLSVEENQPEIFKVFDEFLSNEIILQYFFSQFCLFWDCFFAPKENYSDIMNDSCIFKSKRVQNYYEQVISYDDYFENIKKIYKSMNWNQIIDFILEDQTNILEFNHELLDFIFPNSNIFGKNPDSNIIGRLNNCKSINFSIMIESEYLIAVFIKDFIKKIGEKNFLQMLCMVNFENKKTNFYQNLEYLNMLEPFKTEFIVNLSCSLEFLKKDVHIVVRPLDEAVFCYIQDRNVYCGRRYVATCNQSKKIVNLLAMRCEKMLDHGYKRRNNKVLRFQKILDNEYAEIRLGTGIKKYRRFVGLNYKCSVDIIFYVVTWDGIITNTHKYRDIYTIHSTQKDVSLSVILEAEMHKQPTPSFKQVDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E4</accession>
    <name>A0A4Q9M2E4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0219p0070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000219">
        <property type="protein sequence ID" value="TBU19122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2E4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0219p0070"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="12">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="13">
        <location>
            <begin position="347"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU19122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="474" mass="56526" checksum="9B20ABF4BB752116" modified="2019-07-31" version="1">MLSLEDVGKKVDEKEKFKIYKKIIEKLNYPFIETLYAKFFGSHPVTLSNETIELLINRDYYVCEKSDGIRVLLYIYNDNKFVYSFFFDRKNDFYLVNINNNIKIGTYLFDGELYNDFGKNSSEIVFSIFDCLIYEGNDFSFQNLQKRLEVCQNFINLYKNVDGFKKYKFKIQVKQMFKSYGFYQVYSEIDNLAHKNDGLIFTPVYQPYVFGRCYTLLKWKPPSLNTVDFLLRKNKEVKNCYELLCFGKNNEMIIFDHFFDFEIEEDRGRNVKESNKIKESNINMKNDLYRGEKDGERDGNQNIIPEDKNKGDMKKDKEDRQRDGNQNIKQEVKNKGEMKKDKEDRQRDGNQNIIQEEENKGKINQNDEEFERKRIKISQDSRIQDKTEEVYDGKIGEFVFLNNSKSIDLNDLSIKDGAWSLLKIRNDKNTPNSFKVIINIMSSIEENICFEELTKHFKNIKNGWNYRILNHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T1</accession>
    <name>A0A4Q9M2T1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0184p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0030"/>
    <dbReference type="OrthoDB" id="10601311at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21852" checksum="F03E71CD1C3661FB" modified="2019-07-31" version="1">MFSFLNSKNSMKPKKINIEEIMRYINNTLIVLKREISFQDKNLLELKTTVCRLYKEKQFESAKRNLKMIRIIENTVERLQNQVILLETKRMACLQEIGNREIYNVISLINHEDSRNGINTIKLETKTYKHIDILSKRDYNEEFLFNTNETVVSIDEDLEKFVINTFEHEKDFNRKNLEEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3M4</accession>
    <name>A0A4Q9M3M4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0044p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3M4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="14087" checksum="AEB0F04141EFB00A" modified="2019-07-31" version="1">MNIKDRFNTYKYFNDLWVQDVENKVKKAYEKIKSKSDTDFENNMKIKRRNKATQKTKKDFMSEFKIYENDSPTRNKDNRNLSINKALTEDLTFGEKWVPSGKLIKNDLKKEILVSPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3R9</accession>
    <name>A0A4Q9M3R9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0017p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3R9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="68" mass="8141" checksum="6C4241F287EE703F" modified="2019-07-31" version="1">MNQTHIFNDHYFFNNINMNTEPQNIISPKPNIENTNEKIQNQTQRNAIKNNKKRLGSYKTSPERLFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4D1</accession>
    <name>A0A4Q9M4D1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0046p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11485" checksum="107E8BA6EF569922" modified="2019-07-31" version="1">MKSYDDLPFQKLNSKVIKNSEYLKNWTFYKKINKFSDICPEEILEMPLNRFFGLGIKILQIKVNPDSSKCPIKGIFRSDLADINQIEDADNIEKLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4D2</accession>
    <name>A0A4Q9M4D2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0015p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4D2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0060"/>
    <dbReference type="OrthoDB" id="2194154at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="715" mass="82391" checksum="EB3DA8063A43F7AB" modified="2019-07-31" version="1">MFKKEYKINDINCILILIINWQALLNVAIDKEYGNNLKATWIDVKKAHDSIDHAYLTQVIENLNLPDWILKFIKVTISKWKIDISVGSEKIMNKKIDKGILPGDNLSPLLFVLCMDPLSRKLNEEYAKATIQTEDASHSTNHLLFIDDLKLLAKDGTTLEKMTEEVKMFMKNIGLEINREKSATNVSCCENTATLFEGIGVYKYLGIIEDSRGIPTRKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLINYHIGVLRLELGDFSKLDDAVRAVLVKNKIHLWPGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENDNKTHLALIKDFLQVKYGMAEEVTQNKLDEAQLANLYNEIEKRKIHSKLYNARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRSNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCGVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWESASLSVIIGAEMHKQPTPPLKEVKNEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKANKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4E2</accession>
    <name>A0A4Q9M4E2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0074p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000074">
        <property type="protein sequence ID" value="TBU20416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4E2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0074p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="688" mass="81957" checksum="8A8F710CB73B1912" modified="2019-07-31" version="1">MEKNNLNLDKRGARKTRIDEKKTQQTNINKLVSVQDENYEIDENNPPKRLKVTKSYGIDDIDKYPVKFKIISELKKTENEIAVPIKEISLEQFIHFHNFINSFYIFAEELSFENIYTIIYILDFLGTEDILLIENLMKVVFLKLNTKCNNFDSFNENYIQLGYGIHKKISFVLCKRIFVQYILLLHAKKCENNPFHYNKNGYLLKEKYSFLFNEDRKTILDLSKDFLDEYLKYIRNILQRKIIMNFIMIIINIQTIYIRQYSTYETDKLKFFLSKFFFPFESIIFLNPTFDRSLIDYSDISDELECIESLQHAFINNIVVGNFRSKEDVKNLSFSCPEYSLGSGLNPKEFESSNGITKKMEYYIFFEYNYLFWEITGIITEDESINNLHVDLQDCRIINLDFNEEFILENMKSIVFTETEIDINVFVSFLNNSKLESLILNNIKVINPGMDIKFASKNKSIKSFKIIKPKQKFKNLNISFDEECLESEYREKYQRTDIKTLKELKFSNKKHRDSDISFLKNLEIIEQLILENIKDPDFFLQIFKDMVMDKIKCIRFLNYEIYKIEKDISIFESVETIGFNNCVFKGTEICNFFPSNICKKITFFEFRGIKITQSDLEYLTLLENLNCLTFSFCIFDEDTIYDFPAGSFKNIIVIYLEYHNKGNNKMIVQGFREKFSENILRIHFFNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4G4</accession>
    <name>A0A4Q9M4G4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0040p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4G4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0010"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.440">
        <property type="entry name" value="Killer toxin KP6 alpha-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="824" mass="94198" checksum="74A8B6295BEA71DE" modified="2019-07-31" version="1" fragment="single">MRKPKNKRKEKLELNCSNTSSDTYTGDGYTGDSYTEDSYIEDNYTVDGYIEDTYTEDDYFVDDYTENSFISDNTFFDNHNTIHNTIYDSYTNYIPTLYDNDSLSNKLLTSSPQNNILQSKEEEINLKIKEEIKEKIKEKEINLKIKERGETQQIQEETIQKIKEKIKNKKTLKITDIHFLNQCTYTDNQWLYKLFMSYFSYINTIHHLEKEKEILKYIKNINELFYNCNDNCYSTDMIFKEIKNINSNIYSSYSNLYSNNSNSITNNSITTDNILYSNNSNSNNLHITNNLHITNNLHISNTTDSNLYSKNNNTTTTNISFYDTLLCKTLFYILYPLPLNTTYEIIINFKDILTNKILIFLKEYIFKEKLIKKYKEIENSSLYSNLYSGCSNSSLYSGCSNSGCSNLYSNNNNLDRLDSNMDNIDNIYSNMDNIDNIDSNTNIYINNKINNKTNTNPITNIWPFFKRFTEYGLEYIIEDLFKLLFRNNLLSVNILEEIMEKYKNKLKKCIFIEIKGYISIYLSKDKEMKNIGYFKEMFKNVMGYSLYVCGSKRIKIFKGIFEIIMMNVYKCMEGYKGIINEQQGVSDKSNELEGVSDKSNELEGYSNSSSILEGYSNSSSILEGVGNSSSILEGYSNSSNEQQGVNICSIRQHPVSDSTNNYKGISNSSNEQQGVSNSSNEQQGVNISSIRQHPVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKGVSDSSNKQQGVSDISNEQQGVSDSTNNYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4S3</accession>
    <name>A0A4Q9M4S3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0003p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4S3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020431350" evidence="1">
        <location>
            <begin position="26"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="850" mass="101774" checksum="CB0CF9085FDC25FA" modified="2019-07-31" version="1">MEYTISIFNLYFCCFLLVRFNCCLCSLNVNISEINIDDECILCAENTGYFFLYRGESIILNNCKPKTYEENTCAEAHTLLYPDESILKFELFEIKIVELQPDITIYIKAGEYIDFRSFLKSTASHDSIMVMELNTFFSTLKYLSILKPERNEEYYEFIKSMVFRVKNFNIEYIEKLGLESLLNYKSYDVFYILDVVECSFRYYMLNKLTSYITFHEYDQIFLNSSKKRQIKHKKYKNLTTMQLIGLNLLPYLRFIRSYPDTSWRILRKLLYIDRFYLRDSKDVFNILKIDAFLHFLPENIKKIAIFASENVSLIDKLHSTGLFQLVTNIKIIVDFSFKIFFDKIDTFKGVRTLKFDIFEMETDELMFKCIIPKNYCKKYADKKKPLIGNKNNLSIDSSNQIEIFKDKVNHRELSNDGYYKYLIGVDFDFYTNKSDIFYFKGIFRFEKLTRLNINLFNTKEKALRDYSFIDSLKSLKNIRFINLKITNKLLKNILNCKKLKSLYFKTFTYNKKIDPNKFNILNTSIVYLNFKGLKNSLDRRFFYFLERCKSLQHLIFTDIFIFNSLEKNIRGIEKKLGFNIHPYMSKKPELKTILFIFNSELSYQNGVSILNIISKFFNLENCERLSYYGDSLYHEDLNVFLKIKRLFVLELGIKRNEPTLNIFGKLLETNIKNTVKKLHIHIDVFHNFEFIKLFQFKRLRILELGTASDSDKLRKYIHLFENMNYTKLAIFEIGILLITSVPRMVRKLKKLYDDKTERKIKFTKKRKIKRKNSENELKIENRNENRLSYLNDSKKLKRRICVEEKISKNYKICYNLRQRACHSPYDLKYNDLKSHKKVNSCFTKNICTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4W0</accession>
    <name>A0A4Q9M4W0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oligonucleotide/oligosaccharide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0001p0190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4W0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4W0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0190"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCA2 OB1" evidence="5">
        <location>
            <begin position="413"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="75303" checksum="D4D1FB896264B535" modified="2019-07-31" version="1">MSIPDSIPDSLPSELQDSELLSSDILTDEIIESSFSSNISLYSMKSESDDLLNKNVSNFQSVNIEKKNELEKIQKNNSKIEKEVFEDFSLNGSDSLDISTFTDIISEGCNEQKHVSSSVSFESDDFSDELTIESKKSNDTIIYKNKNFEIDFSKNFNSVILTGFSTGNNKKIAVKEETLKRVSIELEKEDETKSKNKDNLLKNEETKRVNTNSQKKNINTSQNKDDGFLQNESLEKINIDLEKKVENIKKIKIENLPEKNIKKEFSMKSNNLIKKGNKNESFNISGSKIENTFLQEQVGNENRNIIKNTNVRYVKPIRMYNKPEKGHHSTEKRYLEKMANTFKKIEEKYKNEEKEWIFQNFKWTWMSLFVSKWKKESLNGTQIIENQIIDLEENILFEMLDKKINLKKRKEYSILRRICEGDDISYKYMILLIVGIHKNTVELYDGFYSVECIYDKEIEKRIISQKIKIFDKIKIFGAELLEEPKSFFERKGVLLRLNANGFVPTSLNKKLGYQKKVGFVLGMNKICKTGGTVGCVEIKVKKIVEEKALIRHKGYKKEVKIENIEEEVEKVYNMAKKEGVNIEINDINISKNIKIIAECLISGFEALITIWGCEYLKIGDRYRFIFLKINEKATGLHLITFNRSVVQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5E3</accession>
    <name>A0A4Q9M5E3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0045p0070</name>
        <name evidence="2" type="ORF">CWI38_0021p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5E3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5E3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0070"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="173" mass="20240" checksum="A85AA360E9078A40" modified="2019-07-31" version="1">MIRRIRLNPEDAGFYPADDLPEYVEKLEEQFSLCPTPPYRKDLVKGNIVVVLDGEFISSRIIFLKQLPNYMALCIGPFNINKVPLFKIHEKYLLKTSTILDIRCEFHVRENEIYESKVGNKKQFNSNEHVQCDQEKEIQEYVMRSVDNFRGMKGYLAAPFKLPKGFSIPDIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5E9</accession>
    <name>A0A4Q9M5E9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0005p0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5E9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0180"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020587144" evidence="2">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="12342" checksum="59BEE1AD6B5AD3A8" modified="2019-07-31" version="1">MRIKIHIGLFISIWSISFRFSRAEYVGQGVEHTNTANNTSAQNLQKPESKGNTPEQNPRIQAAFGRAVNAFQDAGRRSAERRNQNATSNPGIGNVFEKVQKMQEKPKTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW27</accession>
    <name>A0A4V2JW27_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2596p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002596">
        <property type="protein sequence ID" value="TBU06332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2596p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12918" checksum="BB36F05845FA542C" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPLPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPSTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWE4</accession>
    <name>A0A4V2JWE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2379p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002379">
        <property type="protein sequence ID" value="TBU07592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2379p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8239" checksum="A3785F76FAF38145" modified="2019-07-31" version="1">MGVIMRSEMHEEPIPPLKEAKREEDGVKTLKPKNNTPLIPQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWI2</accession>
    <name>A0A4V2JWI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2311p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002311">
        <property type="protein sequence ID" value="TBU08062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2311p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="277" mass="32464" checksum="9DA05EE2F54B55BE" modified="2019-07-31" version="1" fragment="single">ILLENSKDSYDISFLDEHIPYKNLLIKNFKLFCCLENILNEPYFLNTFKVILNEMNIKSLIINGNIACIIPYKKYYFRILSFGLFKSLVIANFDSPPRSFLYELDSVIDKNIEFLMETLLMKEKHKGLVFNMVQSTENHIESSISVILTCGVAKKIIIEFDNLYTEKNFMDEGVLNLQIRFFDVKILTDFCDSLSNFNDLKTLKLDRYEIDKETYGYLLRMVESMQQLENLTLIQVINDAKYYNFSLKHSNIKSSHLENNSLNKKIVLEDFLALLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX46</accession>
    <name>A0A4V2JX46_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0976p0020</name>
        <name evidence="4" type="ORF">CWI38_1787p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000976">
        <property type="protein sequence ID" value="TBU00534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001787">
        <property type="protein sequence ID" value="TBU10402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0976p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1787p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="178" mass="21505" checksum="F9486694BDA8EEBF" modified="2019-07-31" version="1">MIKFKLKEENIEVRRKKYFLLKHAFTKLDKNIMRSDYTCMISALLDAERETYFKEENGGNNSFFDTIKRVKDRFIRNFSCCGCTFTDFDCYVKHTYEFHDNRSEDLKNEIDKDVLYHAHKSNNLSFDIKKNESADLYSNQEMKKKYPCLIKDCYKSYKNLNGLKYHMIHHHNNEEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB0</accession>
    <name>A0A4V2JXB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1372p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001372">
        <property type="protein sequence ID" value="TBU11122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1372p0010"/>
    <dbReference type="OrthoDB" id="8049952at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="33638" checksum="86263934577A020B" modified="2019-07-31" version="1">MNAKISNDSVCSSFVNYSLHEEHSENEFRPINFAISRNLIFGGTVFNHKNIHKSTWTTLDSDTVNQIDHILIDKFHSYSLLDVGVHRSANADSDYLLLKIYESKTNEINMLKQNVVKAECASITKDKNETYNLMIQKKHIEMREMSNNRTTMMTQIELIQKYNTKLLSREMFSPVNEPDELSFLKQIAVEVKWSDHFRELLSECGDQADTDNVFDKPEDIGSYEDIVPSYEKVNKAVEKPKNIKAAETNGISTELIKNTRGNCIKELTYYLGVIWKEEKMPKEWDKDFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB3</accession>
    <name>A0A4V2JXB3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CWI38_1365p0010</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="PITK01001365">
        <property type="protein sequence ID" value="TBU11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1365p0010"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="181"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="537"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="749"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1121"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1276" mass="143343" checksum="74EB4EC60BC6E9A1" modified="2019-07-31" version="1">MTLQNKDIRSVISSFFQDKVLVSQQLDSFDSFVKSTMQEVVDENATIIIQSTPTADESTRKITIKFGQIYLSKPPIITEPDGQTSTIFPNEARLRDLTYSSPLYIDVTKITENENNNVDEHTYIRVPIGSMPIMLRSSFCVMSDLQEKDTNALGECNYDQGGYFIINGSEKVLIAQERMATNMVYIFPKSQPSPYHLYGEIRSAPHTGSRIPSPFTLKLLRNTKLIRAVLPYIKQEIPVIILYRALGFVSDKEILQHIVYDPQDKEMLDLLKGSIEEAFVIQDQNIALDYIGKRGAAVGSTQEKRIKFAKDILQKEFFPHISQKEFCETKKAFFLGYMIHRLLLVDLGRREVDDRDHYGRKRMDMSGPLLASLFRTLFRKLCNETVKHMQKCVEQGREFNIALGLKTSILTSGFRYSLATGNWGEQVKAMQSKAGVAQVLNRYNFVSTLSHLRRVNTPIGKEGKLAKPRQLHNTHWGMVCPSETPEGQACGIVKNLSLMTYISVGSSTFQILEIFEENGLISLEEVSSIDFLNSIKVFLNGNWIGFVKEAESILKVLKEMRKSGEINKEVSIVRDIREKEIRILCDGGRPCRPLFVVRNNKLISEELRGVKWEELIRKGIVEYLDVEEEETSIICMDVGRLQGSEIKGSVFMESDTDVLGLGGGSGSVVGGGVSSSVGGGVSSSIGSSISSSIINNTNTNTNTNTNTNTNTSTNTNTNTNPTLKRYFPLPSNVNYTHCEIHPSMILGICASAIPFPDHNQSPRNTYQSAMGKQAMGIFATNFLLRMDTLSNILFYPQKPLVVTKCMEFLRFKELPSGQNAIVAIACYSGYNQEDSIIMNQSAIDRGLFRSFFYRTYSDQENMTRPGLSEDFVKPIRSEVIRMKNLNYDKLDVDGLIVPGLRVMGDDVLIGKVVPILDPERSTKNKPVYLKKDSSTPMRSTESGVVDTVLVTNREGYKFTKVKVRSCRVPQIGDKFASRHGQKGTIGITLRQEDMPFSKEGVIPDIIINPHAIPARMTIGHLIECLLGKVSALKGREGDATPFTNLSVNDISDMLVGSGYNKRGYEIMYSGLTGRKMKMQIFMGPTYYQRLKHMVEDKIHARARGPLQILTRQPVEGRSRDGGLRFGEMERDCIISHGMSAFLKERLLDVSDSYTVSVCDLCGLFGIYDGKGYFECKGCKNTTKGSLVTVPYAFKLLCQELMAMNIGPRLRLEEDVRRLCVGRVEEGGGEGRGCVWEEKEQEQEQEEGLFFKDFLKYFVSKWISIFKGGVNFFITCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR1</accession>
    <name>A0A4V2JXR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0635p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000635">
        <property type="protein sequence ID" value="TBU12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0635p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="517" mass="60846" checksum="76458D6E990C3A09" modified="2019-07-31" version="1" fragment="single">EAIGISEKNSAISNGLSGFRKYIFRDFKFPFDSERSSTLGILNREKSIIFFNNEFPDYIFPDKNIFPSDPVIPDFGTLNKFKRANISIILESEYLIIIFIKDYIEKFGEECFYLNFSLENIFNENSENRKILNNVFSSIQKIEPINSEISENLYITLSHITVDVHIAFAFYKLDTRLFSFVQNEILSVINSSDLKEKVKEKIFIHPDIYYVFFDLYKLCFKKATIKYKALRQIKDISFMDLSDYANIYYNLYNFYYEFVNCGKSGKTVDHLATRCEKMLGYDYTRRHNEVVRCLHLLLLNRYKFKSLKRIRSHSVQEIFDNEYAELRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITCQDSLQIVETKKLRKYDLLANDLIISYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVIKKTVETISFDRRRELESGLNAEESWKSEMHEEPTPPLKEEKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXV8</accession>
    <name>A0A4V2JXV8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0485p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000485">
        <property type="protein sequence ID" value="TBU13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXV8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0485p0030"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF155">
        <property type="entry name" value="EARLY GROWTH RESPONSE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="394" mass="46474" checksum="A33B6FA5AD718CBE" modified="2019-07-31" version="1">MVRNRVRKKNDDTKKILPLENRIESIFQEINNSTNIVNEIILKDEQSNSTFKFIIFIVNRNYYLPFTDTVNLIKYFLEKDGFLISKNLYEEIESRIVCSEMGDIYEDFENSELKVVLLNLLNQKFYSEIIKLQKKVRNEYLDISNINTPLINTNTGSQKNISLQDKNIQPIKKEKSDILVKKYSISRGRPKSFKYFKDNKIMSDISLNNIEEHKQTTNHNTSFNDSSLMNLEPTDLILEDTDTVNTLHPFSNDWDNEYVESVVEKVVKNAHKNINSNTIDFCDDFYLIHPDRIETDSNYKNEKIKFQNINQNTGQSSRPFICHYKDCNSAFKRFEHLKRHYRIHTGERPFKCKFPGCYKTFARSDNLNQHLKVHNSGSSSNDKIGSMRFINERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY62</accession>
    <name>A0A4V2JY62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0174p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12805" checksum="CC0B385B1D0BCB15" modified="2019-07-31" version="1">MVDQYILIISYFVRTAIYDKYISKNENFKMVLARNMHNIYHPIPRATFQRSLKNEADLTNENDSNINYQINSPEGENLDKKIKNIENKWNLEYIKGLPPSLRKGKQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM6</accession>
    <name>A0A4V6MVM6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0670p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000670">
        <property type="protein sequence ID" value="TBU12682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM6"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0670p0020"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="18952" checksum="274CC2EFFB18B0A3" modified="2019-07-31" version="1">MGNTGGKKRTYCKKRKHSLARQTSSTRIGEERIKSIRVRGGNEKLRALRLNNGVFTIKSHDFTFDAKILQVVYHPTSNELMRTNTLTKSAVLQIESPEAKQFIEGVGSKEPTVKELDPFFFESNEKGNLYAIVTSRPGQVGKADGYVLQGNELQFYVEKLKKKKSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KRK6</accession>
    <name>A0A4Q9KRK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2750p0010</name>
        <name evidence="2" type="ORF">CWI38_0436p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002750">
        <property type="protein sequence ID" value="TBT96770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000436">
        <property type="protein sequence ID" value="TBU13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KRK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2750p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0436p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT96770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="104" mass="12579" checksum="F69B9E98D76EFD0A" modified="2019-07-31" version="1">MKNSLIEENIKKINLAIEKIIDGLAEIFNVLKITETDEYSELRDMFIIKRRFIEVFDMFLSIFHHLVELKFLRYKEDEKKQSEEVLSLDLFKEMCDKLKNEVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L397</accession>
    <name>A0A4Q9L397_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0589p0020</name>
        <name evidence="2" type="ORF">CWI38_1499p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000589">
        <property type="protein sequence ID" value="TBU01959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001499">
        <property type="protein sequence ID" value="TBU10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L397"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0589p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1499p0030"/>
    <dbReference type="OrthoDB" id="10530539at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="108" mass="13043" checksum="A959C3353D9436DB" modified="2019-07-31" version="1">MDDFKDLKRFENDNLIGCKERIFKVEEIFPFKIYFCPNNIGVVTLLNKNMKYSFYGVEINKKVKKNFEFIEIENKKYGLPFKCKIIELQENNNEYFTEYIAIVLRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L682</accession>
    <name>A0A4Q9L682_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0417p0020</name>
        <name evidence="9" type="ORF">CWI38_2172p0010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000417">
        <property type="protein sequence ID" value="TBU02776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002172">
        <property type="protein sequence ID" value="TBU09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L682"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L682"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0417p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2172p0010"/>
    <dbReference type="OrthoDB" id="2194948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="319"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU02776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="600" mass="69155" checksum="6C6C39566455FEC3" modified="2019-07-31" version="1">MKIKGGSFSSMGLNKKLFYNIPYVHPTPIQRKALPLVLEGTDVMCISQTGSGKSLVYILPAIQRAIEGKRTFLIAPTRELCIQIHKMFKKLLIGINVNLYALTGHSDDKKHCKSNIVISTVGKLKYCLTELKEIVDVDLLVIDEVDRILEEGGMRSDLIDILKWIRKERQTVLVSATLPDECVVVDNEEDALFNENICSNNFFSGNKKSNLDENQDFSKTDETSNLIMEVESKNNDEKENKKVEKISELEKKTKHIDKYQKNFEVDIFKKLKYTQSVIFSDIFLQPLIENPVLVKIDVIVSELVKNYFFYLPDVCKEAAVVFLLKKITDKKTVIFVSTKHTADLLSAIFEGLSLKYVSIYSSMDIEARKINMNKFVSENVNILIATDLGGRGLNIRNLDVVINYDMTDSKNFVHRVGRVGRNGREGSTFNLVSPEDLCFFTEVKNKLYDTECEIGKIPQKKLDEISEKINDLEINHLRRIAIRGNKKAKLFRKKIKVEKENLDIKLHSVFENKTQDSLFNTSEISEVKREILNESNVIDFEKILDTHLNRNHSNTFKTELDTEKYRDQFFIPYGPNNEKKCTYSSYDIIHRKLNKKRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6F7</accession>
    <name>A0A4Q9L6F7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0179p0010</name>
        <name evidence="4" type="ORF">CWI37_0332p0010</name>
        <name evidence="3" type="ORF">CWI37_0520p0010</name>
        <name evidence="2" type="ORF">CWI37_1018p0010</name>
        <name evidence="20" type="ORF">CWI38_0007p0130</name>
        <name evidence="19" type="ORF">CWI38_0028p0010</name>
        <name evidence="18" type="ORF">CWI38_0057p0010</name>
        <name evidence="17" type="ORF">CWI38_0131p0050</name>
        <name evidence="16" type="ORF">CWI38_0254p0010</name>
        <name evidence="15" type="ORF">CWI38_0261p0010</name>
        <name evidence="14" type="ORF">CWI38_0410p0010</name>
        <name evidence="13" type="ORF">CWI38_0705p0050</name>
        <name evidence="12" type="ORF">CWI38_0852p0010</name>
        <name evidence="11" type="ORF">CWI38_0885p0010</name>
        <name evidence="10" type="ORF">CWI38_1452p0010</name>
        <name evidence="9" type="ORF">CWI38_1467p0010</name>
        <name evidence="8" type="ORF">CWI38_1631p0010</name>
        <name evidence="7" type="ORF">CWI38_2301p0010</name>
        <name evidence="6" type="ORF">CWI38_2364p0010</name>
    </gene>
    <organism evidence="4 22">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 21 22" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001018">
        <property type="protein sequence ID" value="TBU00400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000520">
        <property type="protein sequence ID" value="TBU02259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000332">
        <property type="protein sequence ID" value="TBU03219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000179">
        <property type="protein sequence ID" value="TBU04136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002364">
        <property type="protein sequence ID" value="TBU07695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002301">
        <property type="protein sequence ID" value="TBU08131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001631">
        <property type="protein sequence ID" value="TBU10645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001467">
        <property type="protein sequence ID" value="TBU10933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001452">
        <property type="protein sequence ID" value="TBU10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000885">
        <property type="protein sequence ID" value="TBU12132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000852">
        <property type="protein sequence ID" value="TBU12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000705">
        <property type="protein sequence ID" value="TBU12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000410">
        <property type="protein sequence ID" value="TBU13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000254">
        <property type="protein sequence ID" value="TBU18106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000131">
        <property type="protein sequence ID" value="TBU20110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6F7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0179p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0332p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0520p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1018p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0131p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0254p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0410p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0705p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0852p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0885p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1452p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1467p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1631p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2301p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2364p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU02259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU07695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU08131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU17970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU18106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU20110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU20521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU20729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="114" mass="13016" checksum="A84778714BC58F64" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA73</accession>
    <name>A0A4Q9LA73_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0103p0020</name>
        <name evidence="2" type="ORF">CWI38_0310p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000103">
        <property type="protein sequence ID" value="TBU04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000310">
        <property type="protein sequence ID" value="TBU15614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0103p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0310p0030"/>
    <dbReference type="OrthoDB" id="2200790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="22127" checksum="B5F29232172303B3" modified="2019-07-31" version="1">MLLLLLYFYLNDCIFVKFNFIVNEKVYISLNKSYGDYPGEIIGITDTWQSVLTNYCNVAEMRHIDENVYDIFFCGFKLCYDEENNILQGCIGDEYLTKWRLDELNEKEKVYRLRNNGHCINLSGNSILHMSSCDKNYKPNELLKMKIYLPPSPFEKNFGGSQAFNNSLFVYNMSNTENLHRLRSLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBJ2</accession>
    <name>A0A4Q9LBJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0168p0070</name>
        <name evidence="4" type="ORF">CWI38_0382p0070</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000168">
        <property type="protein sequence ID" value="TBU04220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBJ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0168p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0070"/>
    <dbReference type="OrthoDB" id="2190565at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="335" mass="39231" checksum="A22CCAE9030C1616" modified="2019-07-31" version="1">MRVSILTWNINAKKSAFSDLKSIIENEMNADILFIGLQEVYFTFMSTSDLYNRVKDCVGSYNIIGFERLFGIVSFVLSKNNLQSESFRMGLGFLNNGYKGFTSHYIQFSDTNEKNNILFVNTHLTAHEKNLDSRMKQVSECFKAISSAYDIKEIDTIILSGDMNFRVSGIDRQKVYDLIIEKNYEEILKNDQFNNFSEKYPRFKEGNINFQPSYKYIAGTDDFEVKKYRVPSYCDRILCNSKYKHNFTEYKSLENIRTSDHKPVLLRMEFEPIILDNSELLSDIADKNYIYKLYASEMFNFFHENIFLIGIMTGIVASGSYLHFKNKIKQFFEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD00</accession>
    <name>A0A4Q9LD00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1523p0020</name>
        <name evidence="3" type="ORF">CWI38_2711p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001523">
        <property type="protein sequence ID" value="TBT98955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002711">
        <property type="protein sequence ID" value="TBU05758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1523p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2711p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="53" mass="5828" checksum="18BE96EB500254B7" modified="2019-07-31" version="1">MEGEGGVRDSGDSSVYDEGVINKSKGVINRDSKYWGVNHTDSRYEGVNQYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHI1</accession>
    <name>A0A4Q9LHI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2482p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002482">
        <property type="protein sequence ID" value="TBU06935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2482p0010"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="29211" checksum="79FFE265AD74B0F5" modified="2019-07-31" version="1">MFVSQNSCKIRKDENLKKTNEEKNFRGENINKNISLNEKCKYDTRKQLFEGKFAVMNKNVKHVMPYSPFKKQPKIVTKRENNFQNFEFKKKETGEHAEIDSKPFNNFSNHLSLIKSEKNVSNENKQVAVSELSFKNYESGVDRQQSIHSFSNTNDSQKEEKLSKVEKKSDKNIFNKFISDNALNKETEGNDSFAEMKSFKLKNYLEDFENDTDDKKLNDSIYEKFGIKVDFQKNPEASDSFINEEEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHU5</accession>
    <name>A0A4Q9LHU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2550p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002550">
        <property type="protein sequence ID" value="TBU06560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2550p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17342" checksum="A742768C1F02C691" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIH5</accession>
    <name>A0A4Q9LIH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2324p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002324">
        <property type="protein sequence ID" value="TBU07979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2324p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="21522" checksum="A21F797F43DB905A" modified="2019-07-31" version="1" fragment="single">MVSKELKNIMEFESSDSVSAEEVNAQKEPNLNINTEAFDVYKLYLDIVVSLPFIKTNQDTLKSDQKQPNIFFKNCKYINYEVLQNDYFENARRCYSTFDKEFYPKYFGKNMFEKYHFYKICVTYMENRIKKLVSYVKSEPFLQFENFDAFLKKFSPHFNAENVTSCGPSFIPISVNYVGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK33</accession>
    <name>A0A4Q9LK33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex exonuclease Rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2239p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002239">
        <property type="protein sequence ID" value="TBU08609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LK33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2239p0020"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="57"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU08609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="25305" checksum="D8E5AB2C3B27E90B" modified="2019-07-31" version="1">MTKFLPGEKMPTIEGYINGHGSYQENDGLYSSLYGNLVVIDKLMTVQPVIDFRYNPEVGDVIIGRITMIGNKKWKVEMNSKAESTLQLSAINLPGSVQRRKMFSDEMKMREYFDINDILVAEVQKINKSGNISLHTRNEKYKKLTNGLVLEVPAMLVTRYKTQFLKIESIEIIIGVNGFIWIGSDDLNYENMKKILIIANFIKNIANQNKVITDTELLKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNN6</accession>
    <name>A0A4Q9LNN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2063p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002063">
        <property type="protein sequence ID" value="TBU10053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2063p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="815" mass="98068" checksum="06F857C8A60D133E" modified="2019-07-31" version="1" fragment="single">MKIHENVLTNYSENCFHNKIQNESFTEKSKIMFLFKFLTYLMKYTFNHELYVIDNRLSNFLYSSDIDVVYSSFLFYNEYVDSENILRNMRMAKHLSIIDLKIFELKHSILNEKKKDNIDFNSVTAKDYSEETLFFYHQIYLYEFYFKKKSNKIISIEILAGCLSIKLGRKTNIEILLFWIVLSNLSLCDTHLCTCLEIFFKLIGNCIEQQILIEYFANNFQKYNISSHTVNNYLSSHLLKNDCFSGHVLQFISNQAISYIENNKGFILNIEIQSDVVLMFICAPVFLNSKNPVFIKKMESSINNESRHNLIVNFLYAKCFDLTLLYTNLSSDILENIIKIMLEFGLKYENQDLKVRYLEDTLKFYRKNKITLQINTLYNIVSIINIYRENSMKIKIYHILNAVIIIYFRNIEIAYIWEYFNDILSLLATNLNNLLESNEECMDFKVDFIIKCIFENIEYRKKDIEDFRQMSENFSISITRFKFQNLFISADYHQAIDCFWYNEIHLWHFLRLVYIISSQKNIKFISVSKLYSLLVSKPNNLFFSNNIHIIWEISINFMKNFDVDLFREIFLSSLSDELKMFEMVQADKRSIVFLNHLGYFISFLCFYQSKKDYFIIEENFKDRNINKKLLSVFEEAQKIIRHMDYTIENTEIFLNSTHYDFVLNETNCISKNDKLENCLIERFHFLFWYSISQTLSFIVQPFPTKNDAELFFSFYEIFLDYKFDINLLENLRLFINKNLSFLENMIPRMCEIINKIFEKYITLHDLQYNQSKDFQDVMNSIFFNLTELRYKVNIHKYITVYLEIIKILDKYHHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPM6</accession>
    <name>A0A4Q9LPM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1763p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001763">
        <property type="protein sequence ID" value="TBU10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1763p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22159" checksum="E750DC280AEC0608" modified="2019-07-31" version="1">MGHALIKLMVRFEEQLKYDRLLYLSFEASLLNHPGFLNRIKSNLLLAKTHIATLKSQNHRYMKQDTKKYNSQAVESNRDLTSEELNRRFLTGIQNYDLIHLKKIYYMNENKITEFVLSKISKDDSIIVNCLADAFSNTESLIPYGINCGSNGNLFYDVLRFSIRYLKIDSGNKKENRHEESHSYNIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPR9</accession>
    <name>A0A4Q9LPR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1758p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001758">
        <property type="protein sequence ID" value="TBU10439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1758p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021009703" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14650" checksum="09B9C15CC4D7F340" modified="2019-07-31" version="1" fragment="single">MKSFVFIKNFLFLYFFFVREISTSDIQISFLLEKEVKSTFKKIFKQSDNQKIYGKFDLYGKLLSINHKKIVSTEIYNEDEFIICELKKVTLNYPTDFSVKFEYLDILLLKKYKTSNEIYIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPT8</accession>
    <name>A0A4Q9LPT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1745p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001745">
        <property type="protein sequence ID" value="TBU10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPT8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1745p0010"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="368" mass="42824" checksum="86A99449D6F13BFA" modified="2019-07-31" version="1">MYFIGNDRVGFYYPFDYSTTGPMIVDYNDINFKNVKSFSSNQTNEVKVEKPGHLNHDNYTNNGKSFENCDENKIENRNILFKRKLNLSNTNFQMNEKNMEIRNILNSEKCTNQLIKETQTPRFKLFQNYFSNELSSSMVQDIRNQQSNNYFEKDIFKNDSTLQFYSKERGKPIACINPKVIADETEVESKINSEKPPYSYAQLITMALKKGGKPQLTLNEIYTWIVNNYEYYKNADGVWKNSIRHNLSLNKCFVKIARSKGSPGKGGYWALDPNIVSDNDEPRKKKPKKITDSPIFNTDSMNGSHSYSFINLNSINKDEIHDFYKRFDSIYSKGGGLSHRKIDSSNRRYDYLDQVNNFLNVNNLGTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ17</accession>
    <name>A0A4Q9LQ17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0064p0070</name>
        <name evidence="6" type="ORF">CWI38_1654p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000064">
        <property type="protein sequence ID" value="TBU04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001654">
        <property type="protein sequence ID" value="TBU10603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ17"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0064p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1654p0020"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="3">
        <location>
            <begin position="224"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="497"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="863" mass="102023" checksum="11896E7500A54AF3" modified="2019-07-31" version="1">MDQNFTKELIQKENTLVKEKLQIKNTILDRINALAKASSSFIDKPITISNKTGQSRIDFDNSIKYDFDMSFLTENILVIGQCWNNVTEKMSGRNNHKDIKAFLDKKYKSFYTVWRLNTTKDDIFRNCQYFELTDYNLSTIVRICKSIKGYLSFDPKNVVVLEHKGTKNVFALLVSCILRYCKIVSNTNEALNLYLQTTNQQFISNTLNRYVQYFDNFYKRRENYFKKQLHQIIITTLPKIDNARIDNPMIVIYQNGEFLKTFTKNDIIIDQFYIILTVEAFFVCGDLKIALFQSDKGKTIQILELYLNTYDYGHGLYRFLLDDLDFNTNKCLPRKKFEDDFSIDVVFFEDETKISFIYNLEDNFINNLNILNEHFGRNIDVEVLKKLNDDGYDRVLSKTCLYLGFGIEETKKIIDHFYNKGAIKSLDMKKEEIEIFVDRKIKEEDTHQKNTLNFYIQNSGLENLSNYTYLETIPDKIEFTNEFLQSKKTKSLPPKAKKKPLENFTVKKPFHWVTIPKSPNSIFNELENISINIDYTKFEEWFCEPANTEIFVKELEKDVSVLKDTRRIFLVSLSIKSLEKRKIDIYNLSNVIYKNSNQLEYEDLLNIKTILPTEKEKNIMSSYKGSFNDINEVEKIMFKIDDIDLKSVIDILIFERKFYEDNKTVENILLDTKIVYEKILNSNNLRIILKAVLELGNTANYKYYNRKKAFGFKITSLYILQIFKGKKSNQTLFSFLVNSLIKQKPEIFQITKELSLIHKIKNEDIFTTKDRINAFINDYNNCIRIFKCINVDEKDLLIHINQFLSYSYTFLKDITVKYKEIYVYSSIIKRKFGENEKESITDILNVLSSFLLKLEDEYLSFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ40</accession>
    <name>A0A4Q9LQ40_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoplasmin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1637p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001637">
        <property type="protein sequence ID" value="TBU10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1637p0010"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoplasmin-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="23046" checksum="06E73965F765F15C" modified="2019-07-31" version="1">MYEFFCVKAGPDIKTISLDQTCNLLHATLDINFETKNSTSVIIEYDDRSFILCTLTPEVCENFNFSLELPEKQTFRIFTTEKNSVYLNGIYTNNISERKSKISIFYLYLKPYEESTLNIPNDVEFTVATLDNKNTSLSRTSVIVEIEECDVTLCTLIPYNLNNTSFSFAYKSNNTTKFKLIGQDNVFLIGKIITYEEKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ42</accession>
    <name>A0A4Q9LQ42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1737p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001737">
        <property type="protein sequence ID" value="TBU10474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1737p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8453" checksum="70E781C3487F526A" modified="2019-07-31" version="1">MTWDGFVTKYHKSYLKSLQIPQNVITYIQSIVLKKTVESIPFDRRRGLESDRMPKKAGKVRTTAPLKQASNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQA5</accession>
    <name>A0A4Q9LQA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1624p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001624">
        <property type="protein sequence ID" value="TBU10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LQA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1624p0010"/>
    <dbReference type="OrthoDB" id="2200980at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1588" mass="180293" checksum="1046CA54A87FA8F8" modified="2019-07-31" version="1" fragment="single">MPSNFIHPTQIYKKNKKHYTSHTFITHTTTHNLPFTPTHIFPPYILTIINTTLSIYNIDTHLTYNIPFTSVPINCTIITNTHIYQYPLLLVITPYTLYIYSLSDTPLFVTNCSVNIPTDKRNLEKKNKEKDLEDRYDSSRGDSRRCEEYDTEYENTSNTDINTNINTNTSNTNTNNTNTSNTNTNNTTTSTNNTISNTTFGFPYLLIDNTLYYIRIKNAFFSPLKVSLIPYNYSKLYFIFPFLLNSPKILHFSAYDSYLVILTIQHIQLYKERVNICTITPRRKDYKAIGIIGDLEEDILVICALNDGSRDIYSTRCYIRTIPPPLYHPSDSYDKNCSNNRICSIPPSLYPSSDSYDKNSSNNPTGTIPPPLYPSSDIYDKITTFFSYSDISYVNNTEYPNPSLTLKRCIKTNSKISLIPVFIRYSNNSVIISYLKENQLYNYDINQPIENYQIFNTSSNIKNIFIKNNIKYFNNTSITTPYCTTSTTLYILTGNKLYIYNRVPLHKYLLQSKPEELYLLSNAYTHKELQLCYLTLISEKEDVSGIQHYFSDVRVSYSTLISEKEDVSGIQHYFSDVRDYILEEWVYRLVEPLLKRDLMVEEDVDGYVVEVEKCIKLISNVVLYSTKSKGGSGNSSSVIGGLSNRSSVVGGLSNRSSVIGGLSNRDSQQQGLSNRDSNQQGLSNRDSQQQGLSNRDTKQQGLSNSTYEQQGLSNTTNNTPNTPNITYSVNNVLTTLTFIKVLLSYDTNTLLDTLSTLYPSLTLQSLLISQIETVISTLISNNILSCIILDTLLNNSMFRNSTLLRKKRGFDLISKRSKKSMEESVNVLIEWIKSGIDINELKGVINMYVNNRYYSGGGVIIREWYKTVKPVISYNMLISLINSVLYCKGALKEFLFTEKEDFGCAVLECVLQELKNNKCLFFNTECLCCVRSERVVCMGVSDIIKVSELSGYSSCKKERDYGNCGNNSGNNSRDSGNNSRDYGNCGIYNDFNSNYSRNSNYENRNNNNSTINNINRNLNYNSNINNINNSNNSNSSNINNRISNGNENKFISDPFFLQTFFKEKMHLSVENEESDLLWKYYCYRNDRRKAIEVLLQRIESVELEKKREYLKICSTVEKSKKIEFMAICCDIQIEAVRRIKNNNLEMNMCGIVGGGVGGNRNNNLEGNMSGFVKGDSLMGGNRNNNLEGNMSGVIGGVVGSDSSMISKGRFNVKTDPCFTNTAFLNFNLLSPQPLFSDVCYFMKYYDLSIVLGYKVEIEKEIIRKVWNEVVKKEDWYKILIYVISKVGVMCSEDVVEALVCNGYVKGDGNLIKKLCDLGLKKEEVLVCMGGCIEKVGCPGSKRMVMMEIEVCGGRGIGEKYGVDGNIRNEKIKAVNNLENTTVEILMCDVAMLSERLPPPPTFHNTTHQPPSSSCQNSLVCLVDTIPSSSGTDATAFGPANGMTNLNTHAILEGNRLVVLHSILDSVTVVGQEWPRSAILAVQKRFERMPRNGWPVTLRYYNEKFSCTIDIDAEIRQEENRERRRIATCLTEPCTLTDTTEYINLRDKFLSKIKEISEKEIGKVVVRTRKLPSELVDSKVLDLINRIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQB4</accession>
    <name>A0A4Q9LQB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1619p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001619">
        <property type="protein sequence ID" value="TBU10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQB4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1619p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="37513" checksum="684E339C384605D2" modified="2019-07-31" version="1" fragment="single">MNLICFWFIRGLYFLEVLYAALIPFSNINGRKKIEENYLHFLSCEIHKYYSYTDIEYLSSGGYGHIIKATDIATRETVVIKVAKSNEYQISLTNEKSFLDKLNHLNIIKYIREIKINNKTCLVFPFYENTLESAFLHKFFDDNEIRFILKQILDALRYMHNKGIIHNDIKPGNVLLQGKGCVKIIDFGISCNVNRPIKIFEGYGKSDIDQTFEFYSPEIRRNDLYNEKSDMWSLGYIVKYLKEKIRWSSLYEEMFKSSDYSNFVSCFLNNEAEKRISASTALMSNFFEGLNEFMYCFCKIKDQSFSTPGYTFFKLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC2</accession>
    <name>A0A4Q9LQC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1585p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001585">
        <property type="protein sequence ID" value="TBU10723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1585p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="19007" checksum="4A5695E0A6540A68" modified="2019-07-31" version="1" fragment="single">MYFHKFLSKNNYILISGDEKNQKTPEKVSKLSKNCLKKCSTSNTQAGSSSSNPKCKKIDFKKTETKIQSLPMRTPGNLSCSYQCEDERNLDLSTPKSNTIHASDKIHTDIDLARCLVSHLSYSAPVLETSNVVELDLVLKNIREYRLNEIYQDISIIFKYNVLFCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC7</accession>
    <name>A0A4Q9LQC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1684p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001684">
        <property type="protein sequence ID" value="TBU10554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1684p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="19544" checksum="2CECDA9CC1ED7FE2" modified="2019-07-31" version="1">MNYMHKNSRIKIIFLKKDIKEIVIENSKITSGFLTDVFNVDGLESLEISFSDLFIENKICDKNESVKYFRFTPKNIADYHYVYELINIMVCLKEVYFDAIVNLKLSRSVTRIFYITELYLRNVGRTMYFLKLSENNQNFDFRTTNEDNLDSECVLYSLKALFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQI2</accession>
    <name>A0A4Q9LQI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1587p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001587">
        <property type="protein sequence ID" value="TBU10718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1587p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8150" checksum="FCACE65DC07D8902" modified="2019-07-31" version="1">MQFGESVIIFIEGAEMHKQLTPNLKKVNNEDDSIKQLNKTKVLSPILYGVTTVKEQTKNINEESDLEEGIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQI3</accession>
    <name>A0A4Q9LQI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0803p0010</name>
        <name evidence="1" type="ORF">CWI38_1740p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001740">
        <property type="protein sequence ID" value="TBU10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000803">
        <property type="protein sequence ID" value="TBU12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0803p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1740p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22403" checksum="8CA0B3EF5F6143DB" modified="2019-07-31" version="1" fragment="single">MRYNSQHFLLDEETLYADSDTKKKLLPKSRIEKAWDELSDYYAKRLEDTNRDIIESTKLSNKISQARLEMETYRSVDDLISQNILKEYICAEKPVKNLQGSIKPKICKMCISIADKYLKIFDEAVECENKINNILSKYNRYCSDQDNYTQKSYKIILSDGFIKIFVTQQIYILLNKNCEFIYPEKWLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN5</accession>
    <name>A0A4Q9LQN5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1610p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001610">
        <property type="protein sequence ID" value="TBU10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1610p0010"/>
    <dbReference type="OrthoDB" id="2193727at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="93435" checksum="F88B4EF9109BE4C9" modified="2019-07-31" version="1" fragment="single">MKVKEIKTKVTHKRKQKNKNEVKKHKKNSENRDNRTKEDRSNRGDIIKSRREDGRQDKQSKERHSKERHSKERHSKEGHNIQRQSKERHSKERHSKERQSKEGHSKEGHNIQRQSKERHSKERQSKEGHIKEKHTKDISKPSKHNKERGNKDKHTKDILTPSNHNKDEKTKENRKKNSNESLDDVESDVKKEWEKARLKNISSSERNISINLIYKKMKGKFSKASRRRDFSKLIQSLIKYGNVEIYTNIFEEIKDKIIELTCCRYGRFIIEKFITRNFKIREKIGNIFKKNCKILICDRIGISIFNNLYLSLKYHERNEIIKSLMGNEINLLFNKNKLDEIPIEKIKLNEIYYKITRKGITNYQIAHDIIFYHLKTLNENEQEAVLKELKEFMVDLLHTRSGIKISDKILLKSFDKKEILKNLKPYFNKIVMDSNGVIFYLRVMSICNEKDLQKYFYKNLRKNFKELFLHKNSSLLYFFILNKEKKYFPMLFNEIQSENEIINFEANVFNKSNNKLESKEEDSKAKEINDKEIDTNEILKKETDTNNKISKNTTAFLIQKMEKYILKNLKNCILNERFIIVVELCKRNEEIFKEVIFILKEEINKNILNDNYGVMFVAALKKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIETKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQZ2</accession>
    <name>A0A4Q9LQZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1541p0030</name>
        <name evidence="1" type="ORF">CWI38_1773p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001773">
        <property type="protein sequence ID" value="TBU10421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001541">
        <property type="protein sequence ID" value="TBU10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1541p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1773p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7562" checksum="500AB11671BD2572" modified="2019-07-31" version="1">MNVEAYIQSIVLMKTVEKISFDREEDLKSWERASFNVILEAEMHKQPHLEPTININEESNLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR06</accession>
    <name>A0A4Q9LR06_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1615p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001615">
        <property type="protein sequence ID" value="TBU10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1615p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51009" checksum="AF5BEDFD8033AAB5" modified="2019-07-31" version="1" fragment="single">MGRRNKVDSENIKNEKIKAVNNLKNSAGEILMCDVDVAMLSEGLPPQPTFHNTTHQPPSSSCQTSPVCLVDTIPSSSGTDATACEPANGMKNLNTGAILEGNRLMVLHSILDSVTARMPRNGWPATLAEREIRQEENGERRRIATYEFLSKIKEISMKEIGKVVVRTRKNPNKLVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLDKTRKQEKLSTSETKSLNKITREFNLNLSSVTDLSVALVKKNESLNVYEKKNSKHESKSNSEKRIICFSSSERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYDFFIKKLTTLHKYIYDIVKVICLEGTTQADWFYCGLTYLISKGILQRGSDYRPITCMSNLYKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRF2</accession>
    <name>A0A4Q9LRF2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1381p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001381">
        <property type="protein sequence ID" value="TBU11109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1381p0030"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45636" checksum="CA60E27D88FC25CF" modified="2019-07-31" version="1" fragment="single">MDSNIFVGVKINKEKSATNGKCCENTTTLLGGVNVCKYLGIIEDREEFQHVSLLQLEPTDFSKLDDAVRAVLVKNTIHFRPGCKERLYLLRTELGRGLHSVELRSEHMLLQVLDRLEKSKEISTRRAGILKVENNKKTHLALIKGFLKAKYRLVEEVTKKNLEEDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGYDYTRRHNEMVRCLHLLLLNRYKFKSLKRIRSHSVQKILDNEYAEIRVDTRIKTDFKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGFIMRAEMHKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS06</accession>
    <name>A0A4Q9LS06_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Probable phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_1499p0050</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001499">
        <property type="protein sequence ID" value="TBU10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS06"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1499p0050"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000178">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="215"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="480" mass="55820" checksum="B2C41D61E9072056" modified="2019-07-31" version="1">MDEEIAKLILNKLYISSSITSKGISEDGKSITGTLMSLESKGLIKYISNDEYYYVLSDEGNSILENGSHEYIFYNLISSKGMEIEESKKYEIGKLNAFKKQWVVKRGDRIYKNVCEITDDVCESLKEINCNNFSKKISNEMLNSLIKRKLIVKKKKIEYSIFRGVNYCNEIEKLETDLTHKMVLDGSYKAKSFKSYNFDSSGILPMAGELHPMMKIREEFRKIFLEMGFEEMPTNRYVETSFWNFDALFQPQNHPSRDSHDTFFTTDEFTDEVVPEKYLERVKNVHMRGGYGSSGYLYEFDEKETRRPVLRTHTTASSCRLLYQLAAKDFVPGKYFSIDKVFRNESVDATHLAEFHQVEGVVVGKNIGLGHLMAIIKQFFRKLNMDRIKFKPAYNPYTEPSMEVFAYHEGLKKWIEVGNSGVFRPEMLKPMGFEDNVRVLGWGLSLERPTMIKYNVSNIRKLVGHKVEFQFIKDSKICYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS66</accession>
    <name>A0A4Q9LS66_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DIS3-like exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1381p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001381">
        <property type="protein sequence ID" value="TBU11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LS66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1381p0010"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1281" mass="144376" checksum="E6718B8407BBC366" modified="2019-07-31" version="1">MITHTYTRKISNRKKLKKTILFNHTRYIDLPHIDHTHDTVPYILPTSTLLLYVDINKLLKISKNIIILQSELRKIQNINLKRFYRIKQYISYTGVIYILDLFDINVVGVKYLNSYQLGVNTFYLNSLECIYNNCNNTTCICSIKGDRERGESSKLEGVSNTTNRQQGVSELSNELEGVSNSTNGQQGVTKLSIEQHPLNNNTIQYPLNNNTTQYPLNNNPIQHPPNNNTTQYPPHYNILRVITYLKNIYPLSSYNILTLPLLTYKTPLIYNAITPYTGYIKINNKKIQIYDNNGAIDNDTVSIRDSKIISVINRTDKEFVCCFKDYIFYNENSSLDDEIEENSSDRGILESVNNKDSNIKGVNNKDSNIKGVNESSNEQQGVNKLSNEQQGVNNNDRDIKGVNNNDSSIKGVNENTDKQHPFNTTNITDRTYSIVVPCDLKIPLIRIKTVNYKELLNKKITVRILPYLSNKRIYGKIINVLGNVGDMFVETQCLLLKHCIEYDSIDIERIRRGCTQIINTINRDKNYIDPNPSITLNTPIKPNPTLTLNTCINTCAISSNKTVSYFDLDVYESSIPFLKGSNVTDSKREDLTYLNVFSIDPLGCTDIDDAISVRILKDNSSSVNTLLSSSSINTPLDNSSIINTPLDNSSIVNTLLSSSIVNTPLYNSSIINTPLDNSSIVNTPRNISTDTNTPLSTNLITNTPLTNTTTVEIGVHIADVSHFVQSGSEMDKRAMRRGTSVYVEGGRVDMIEEWLSGDVCSLREGCRRYAYSVIIEVECYNDIKGVGNSGRELGSVNDMGSKLEGISDKDSKLEGVGNKDNKLKGINNMERKLEGISNSTSKQQGVSNSTNKQDPVNNLSNTLPPFNNTTYTNNNLSNTFTSVRISNVRFTKSLIKNTKAFTYEEAFENIKNIKNKYSKDMNLLWKIVEIIRNERKKEAMDLSVGGILTNFLVEEIMVLTNSLVGKELIRKRGKGCLLRIHTESEAIRSMCTEGVTYKDSSIKGMEGVNYMDSSIKGGVGVNNKDSNLKGVNYKDNIKDLKDTKDINNISSKHHIIRPSNVDIKVWRSYMARCMDRAKYFINNGNIKELKHYGLGLDVYTHFTSPIRRYADILVHRQLYEVCSNNSGCDTINTEISNNRIENHTGSSITSRFDNNNDSPTNNNKNKNSSSSTNNTNNTITILSDCTVNRLNDKNYSAKVVSRESRMLKIYYQVSGSVMEGCVIGVKDNGVIIYIPDCDVEGFVKVEEENKYKLFDNIRVKVGGNDKKFFSGRGYDFEIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS75</accession>
    <name>A0A4Q9LS75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5097 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1239p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001239">
        <property type="protein sequence ID" value="TBU11379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1239p0040"/>
    <dbReference type="OrthoDB" id="2196404at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031511">
        <property type="entry name" value="DUF5097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17020">
        <property type="entry name" value="DUF5097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5097" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="12881" checksum="10886C2E3DA60E70" modified="2019-07-31" version="1" fragment="single">MIESISIKKYIAQYFLENSVQPITETVNQIVQTLSANFINDETVFVKSKEMTGRILSSYQGTYIVGLHYENKMETDKILYKDLMRRDQITKNEVMNYLQNITNETPFGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSB1</accession>
    <name>A0A4Q9LSB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1351p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001351">
        <property type="protein sequence ID" value="TBU11157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSB1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1351p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="51183" checksum="091B0E6B6D06112C" modified="2019-07-31" version="1" fragment="single">NRISSIRNNLYIFSNLFNNIRYLNLLNRISSIRNNLYIFSNLFNNIRYLNLLNRISSIRNNLYIFSNLFNNIRYLNLLNRISSIRNNLYIFSNLFNNIRYLNLLNRISSIRNNLYILSNLFNNIRYLNYSTKLYNHTSIIISHYSKHFLNIKFFLEFLPILIINLDNILLNIEINKFEKKIILQNIIVSSRIQNIFNILNTITHFIPKEYQQVFRKYISYYFIYISFILQYFSNLEPNTILTDIKSSKSNNMIDSNTNSNRDSNSNRDSNSNRDSNMFDSITNSTNSTNSTNITTNISITNNSNISITNNISTYLRINNHSIINYFYNFLFHSILFNLDNIYYTQGIIYEYTTKSFNNIMISKIIYLMNRIVIKDNYLLIYILSIYFIYVSINIYLYLFIFILSLIIVFFIEIFLHSNSLLENVKEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG6</accession>
    <name>A0A4Q9LSG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1169p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001169">
        <property type="protein sequence ID" value="TBU11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1169p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="38921" checksum="F7AAE1D96DBDA2BF" modified="2019-07-31" version="1" fragment="single">MSRRKKVDSENIKIEKIKAVNNLENSAGEILMCDVDVAMLSERIPPPPTFHNTTHQPPRSSCQTSLVCLVDTIPSSSGTDATAFGPANGMTNLNTDAILEGNRMMVLHSILDSVTVVEQEWPRSAILENGWLATLRYYNEKFSCTLDIDAETKQEENREICRIAIFLTEQCTFTDTDKIKQISQKKIRKEVVRTRNLPSELVESKVLDLINRIIVARIIQAAQVCYDEATRKEKPRSAWKENIESKISKLKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKIAIHESRKQFRKENRMFELFHGQFYRGLSERIESEHVVSRDEIVSFWSTMWNKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR3</accession>
    <name>A0A4Q9LSR3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1110p0040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001110">
        <property type="protein sequence ID" value="TBU11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1110p0040"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="36174" checksum="257E73DF3B1AE70B" modified="2019-07-31" version="1">MSENQNQDEQGNNGEGKNWLKIILTIVLVIIGISILGFIIYYLMVKYGSSSSAGGAALAPKSKGSTKEGKESKESSSKDNSSKDNGKDKESALIGEPLKQSAESMAYSSFHPESNIASKEEKSEKKKKGAKSALHEGFDIKNDLFAQKEVYQPGSVSVTKTLLYNFSVIKTPLYNFSVTNTLYIPLTLLFITTVSKTLYITNTYLRPLIQHYYKLSPPYLTLVLLRPFITHYYPLYNKYVSKTLYLTLLLLTSFYFLFLKCPLKMLYHYLEDNIRKYTLKENNNTIQSHPCKFSPVDELSEYRVVIKKRFKIKPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH0</accession>
    <name>A0A4Q9LTH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0984p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000984">
        <property type="protein sequence ID" value="TBU11913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0984p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="22895" checksum="F8FD00E4E34301AF" modified="2019-07-31" version="1" fragment="single">MWIKKNSRREDDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR1</accession>
    <name>A0A4Q9LTR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0935p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000935">
        <property type="protein sequence ID" value="TBU12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0935p0010"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8386" checksum="84A1CF026B2B45CE" modified="2019-07-31" version="1" fragment="single">SVGCPFLGDKTYVKNFLNIKNINLDLEDLIKSHPGQKACSKILNVLIEQEAEPFITSPVNFHNLFKNKNNKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS4</accession>
    <name>A0A4Q9LTS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0983p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000983">
        <property type="protein sequence ID" value="TBU11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0983p0010"/>
    <dbReference type="OrthoDB" id="410381at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="702" mass="80069" checksum="7DD5EBAD628EAEAB" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNIKIKDANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSRLDSLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFCSTDKLHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSDENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVGSKVLDLINRVVGEYAGAHVPASITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQENPSTRKRKNEALNVYENNFTMYENRRKFRKENRMFELFRGRFYQGLSERFESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPPPAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTPQADWFYCGLTYLIPKENPQRGSDYRPITCMSNLYNVQLIVERRGLLAENQLGAQALLNIALNKEYGNNLKATWIDVKKAIYSINHAYLTQCIENLNFPDWILKFIKVIISKWKLIYQKKIERGILQGDSLSPFLFVRNLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLSHTRLNAKNLFSAINQHAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU3</accession>
    <name>A0A4Q9LTU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative U3 small nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1128p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001128">
        <property type="protein sequence ID" value="TBU11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1128p0020"/>
    <dbReference type="OrthoDB" id="2195826at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="386"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="709" mass="82446" checksum="A82CCF7DDA40886C" modified="2019-07-31" version="1">MISILQIDRSFIPISDTPYFYVNEINFYTIFDSSIRITNLTTFKVKEIKFSKKILLFTIHNNKIITYDSALNIIDLFGNIIYKNNIQNYTILCMKGIEDFLIFLCSDKCVRRFCFTTRKIEILFKNKNSYKFLEIKNKKIFVVDEIGTVLYYDLTSNILKTHEFNEPIRSIYCAENTVNPCITVYISFVSGKLFIYEFITSSVIETLELKKDFLIFNYENQLYGINNIKIYFLQNDRTPKKLLNVYCEIIKAEIYFDNLILVTNEYDFIVVDLKDFKIKYILTGNADEITDMKMDNKKRIFISTNSEILRYLDLNDFNENGKFACKSYLLKGHRDAILSLDLSDEYLISGSRDKTAIIWRIEGKKIKKIKKLKTHTDSINGTAIFKDLIATAGKDKTLQIFKIKNDKIKTIFTKQVHSKEINSLEISKYRKMIATGSQDKSINIFDFNGTILKSIKSHTRGIWSVSFGQNILASSSSDTTVQIHNLDTYDSQILHGHTTAVVKCLVFNNDTQVISSDLNGIIKIWDTKKLKCLNTLDTQNTKIWSLFYHNGLYTGTSDGQINFFIDITESHQTAIKKSKENLIQTNFLIQRSIEDKNYLQTISLLINKEILNNSDYTVIYSILEDNFCSEILSEIIEIIFTRKEAVINAINKFIISFKSVQIIDLLLRCLIDRKMLNEEDCFKIQKNLQKQFKGILDLYSNVICYDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU7</accession>
    <name>A0A4Q9LTU7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0926p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000926">
        <property type="protein sequence ID" value="TBU12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0926p0040"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="33369" checksum="C458D8A4A7BA1DEB" modified="2019-07-31" version="1">MSDRLPQDINNIEIPSRGRPRKKEIHLDGLTDEQRMEYFNAKGISPGQLFGDDTGMRDRRTDFNTFDYGGPQPMNNNPQQYPQPYTQPPYSQPYTQPYNSFYPEYPFYQPLNDNPWMNRKKRKNNPLLWQYIKHHQDFYPNILHPSKYSSLDFIQGTDKSQKMYIGTIKRAPPFIEKNNHNSILPLYLNSAHPTEQQHIDEFKKISTNFLNKTVELDYENVTVQQLKAIMKEFGLNHTGKKIDLIDRVKTTITKIEERKRKDKKQSQEIPEDDKDLNFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTV1</accession>
    <name>A0A4Q9LTV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1123p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001123">
        <property type="protein sequence ID" value="TBU11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1123p0010"/>
    <dbReference type="OrthoDB" id="2195910at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021006009" evidence="2">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="265" mass="29629" checksum="20E85EE9929EFFB8" modified="2019-07-31" version="1">MNYRAFIYSLLLMEITLCTVCNDINDVIMGAGIYVPDNKSCTSHTSVANSGSSGAGTYSSNTPVTYQSGAGSYPSSTTPLSHSSVPQYPSMPQYPSMPQYPSLPYPMASLNTNMQPSSQFNTLSPTMTQPLCNEKDYSSMCDNTSERDKFKKCVSDALRKLRSVIDNCKKTLGDVSECCINEECLESLKTKKKEECKDSLGSFISFLKKKLNRIQRKKSFKKKSKRGRFGRESEESGFTSDYESDRSEGQKEKKEKKKECEDPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW3</accession>
    <name>A0A4Q9LTW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0778p0020</name>
        <name evidence="2" type="ORF">CWI38_0915p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000915">
        <property type="protein sequence ID" value="TBU12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000778">
        <property type="protein sequence ID" value="TBU12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0778p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0915p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="224" mass="25610" checksum="274E4D18705528CD" modified="2019-07-31" version="1">MQGYLDENGEEWTENKDIVVTNKVPKIFESSGLDKSGYIFDSERYYDARGDLSDEEYYSCSANSESFKGNREFLNEKNERAVSFRKTPINESTEPNDKQAIVMNDTSKPFGVIKNSSLSLITRGKISNFFENEFNMIRDKLISRRESKKSETLIGNSPSLSNFPLKRDENYNENERRKAVKTPTFNSKISFLSLNTRKGSKRNSKKNNETGKSTDAVSNNVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU55</accession>
    <name>A0A4Q9LU55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0865p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000865">
        <property type="protein sequence ID" value="TBU12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0865p0020"/>
    <dbReference type="OrthoDB" id="643377at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="606" mass="71825" checksum="9E0487EA8CF5CDC8" modified="2019-07-31" version="1">MTEKKTYENEVSKLKTRITISKKFKDIIFERLYSASVSFTSKTISFLENDFMNFLLIDQNVEFSNNDLSLFSFSDYSATLIKEISKNDDTILQFFYCFFALFDIRKFVLYSSSVEFDKIYSILESIIKNLDEIIFYNQLIQNNMIICFMNNKMFRNIKHIHFIATKFQGERKFLTNIFPNLEIVSIIFLVNRQLEIEIIKNSDINAIIQVLKYKFVKDFDDNIYRLIGAGCTQKNNENSEFYITKNTRLSELDNLILFKNEIIKIFVCFKNSVTSEILNLFDSFTNLKNIEIHCKPIENCEKFLREFYIFKSINKILLRRYKIEKHIVQGILNLFNLRILIVEQCEFIHIEDNLIYSINNEIKDFDLIHNFQDENINILRFLNTLKKLESLIINSTNLSKILSKNEFKNFISNQNFKTLTLSSDECNFFEIPYSLSCRILKDFHFSGKFSSGTTNGLFSGMKITDLKQLSISYCYINQKDSLVLEQLNSLVYLDIDNCNFQNITVTELFCLEKEYVIQEMILIGVKIYINDIKFISKLKYLVDLTLNNCKFCDKSFLHLKGSCFYNLEYFFISYSNATEYDEGIDYLTEEFDKSILTITWDIYDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG1</accession>
    <name>A0A4Q9LUG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1226p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001226">
        <property type="protein sequence ID" value="TBU11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1226p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="541" mass="64309" checksum="1213DB7A647D6C70" modified="2019-07-31" version="1" fragment="single">MNNNIEIYLCYHIKKSDFLIFYEFIISYYLPVHKMTIETFYTISYFLEYLRVDYDNKLRNSIRNIWYSLMESNKMNNLDLKRYHYFSHDLYKKISQEFLKLLNIKKNSRFSFSSKENESYIYDEYKGLFTKDRKHTLLINDKFDSFFYSNWTHTNNIPSKNPSKKMQKIPKETKDFYLKLLKEVEFRDKVKITECFQFKNHDLPFKCFNVYKGCFNNISITLKELNDKQFFTTENTILEENIKSIEIYLSVMKSDFLRDILKIKGLESLGIFYSDIIIENRKTNKEKSATNDKCCEDTATLLEGVSVYEYLGIIEDSRGIPTRSSFEEVQSKLIARFERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLELADFSKLDDAVRAVLVKNKIHRRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEITKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL4</accession>
    <name>A0A4Q9LUL4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="11">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1291p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="11"/>
    <dbReference type="EMBL" id="PITK01001291">
        <property type="protein sequence ID" value="TBU11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1291p0020"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="13">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="470" mass="52066" checksum="B5AB220AE90E606D" modified="2019-07-31" version="1">MIFDLGKSIASSLNSLLKTQVTDSKIEATLHDICNQLLSSNVSPKYVDVLKQNIRANVFSKEIPAGVNKGKLVYNAVYDELLKMLDPKSAPIKLERNKTNVVVFVGLQGSGKTTTVCKYANYYKKKGFKTGIVCADTFRAGAFDQIKQNALKIKVPYFGSSDPDPVKVAVEGFERFKKDKFDLIIIDTSGRHTQERELFQEMKNIITKVTPTKIVLICDAGIGQSAEIQAIGFKNEVDVGSIIITKLDGAKNGGGALSSVASTGCPIEFVGIGENMDDIESFDAERFINKMFGLGDVEGLVETVKKLNIDEKEMMKKIGSGNFTLGDYYDIFQQIMSLGPMSKMLSMIPGFSNVPIPDEKDFRKMIYIFDSLTEKELNSDGSFFEKQPSRIFRIAKGSGTSVENVQNFFVQFKTINSVMKKVGNNPGMMDLFNMDPTKMTTTQKAKLRQKANGVLPKDMVDQLNMFLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ7</accession>
    <name>A0A4Q9LUQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1268p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001268">
        <property type="protein sequence ID" value="TBU11320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1268p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="366" mass="42357" checksum="304097DCE5E33135" modified="2019-07-31" version="1" fragment="single">LGRGLHSVELRSEHILLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVYHLATRCEKMLGHDTPGGIMKSHSVQEILDNEYAEIRVDTRIKTDPDIFFLNKKKNKITLIELVITSQDSLQIYDLLSNEVGLIYKCSVEIIPYLMTWDGIVTKYHKSHLKRLEVPMNIEAYIPSIVLKKTVETISFDRRRGLESRLNAEESWERASIGVIMRSEMHEEPKPPLKEEKRKEDVVKTENKKNNTPLISQGGTTLEEPTNYINEESDLEEETEVVKDVKVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS2</accession>
    <name>A0A4Q9LUS2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1172p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001172">
        <property type="protein sequence ID" value="TBU11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1172p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39981" checksum="CAACD5B0F5B5EBE8" modified="2019-07-31" version="1">MMQFDSSVFRFEFSVSNSSHIPKEISIIIQNICIKGFIIENAGIYKNIRKICIWDSTLTNKFLADILIFPNLEDINISSCKVLSGQKILYKRHENMKILFLCGTFIDNSKEIIDFVNCMPNLKSMDLRKNTNLNIFDHHSQNNKITLNYLEKLYLFDENEYKNDIPDISNLKSVTSLHIGEEYNYGSIHKLFYNKNLKNLKNIQKLSITQFEIDKSDTYSLQECKNLIYLYLDNCKFTDISFSQLFDSNKSYKLENILLKKMFLTATDIKFLSKCIFLKHLELQIYNVPKELIEWLKLLRLDNSKPILELVIHISSKFWIEIGLLKEYLHPNTQKLYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX5</accession>
    <name>A0A4Q9LUX5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0744p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000744">
        <property type="protein sequence ID" value="TBU12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0744p0030"/>
    <dbReference type="OrthoDB" id="2193727at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="93914" checksum="33EA3DCA64B4313D" modified="2019-07-31" version="1" fragment="single">MKVKEIKTKVTHKRKQKNKNEVKKHKKNSENRDNRTKEDRSNRGDIIKSRREDGRQDKQSKERHSKERHIKDGHNIQRHRKEGHNIQRQSKEGHSNERQSKERHIKEKHTKDTSKPSKHNKERGNKDKHTKDIPKPSKHNKDEKTKENRKKNSNESLDDVESDVKKEWEKARLKNISSSERNISINLIYKKMKGKFSKASRRRDFSKLIQSLIKYGNVEIYTNIFEEIKDKIIELTCCRYGRFIIEKFITRNFKIREKIGNIFKKNCKILICDRIGISIFNNLYLSLKYHERNEIIKSLMGNEINLLFNKNKLDEIPIEKIKLNEIYYKITRKGITNYQIAHDIIFYHLKTLNENEQEAVLKELKEFMVDLLHTRSGIKISDKILLKSFDKKEILKNLKPYFNKIVMDSNGVIFYLRVMSICNEKDLQKYFYKNLRKNFKELFLHKNSSLLYFFILNKEKKYFPMLFNEIQSENEIINFEANIFNKSNNKLESKEEDSKAKEINDKEIDTNEINDSVINSKETEVKDKEINNKVTEVKDKDTNEILKKETDTNNKISKNTTAFLIQKMEKYILKNLKNCILNERFIIVVELCKRNEEIFKEVIFILKEEINKNILNDNYGVMFVAALKKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIETKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ1</accession>
    <name>A0A4Q9LUZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0769p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000769">
        <property type="protein sequence ID" value="TBU12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0769p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="269" mass="31527" checksum="D7C2C5D84CD0AA83" modified="2019-07-31" version="1">MYYLANRCKKILGMDIPKRINLGIGFPHLLFINIYNLKFLKLIKSDSVPEILDNEYAKNNSPEILILELEYQKNDILAKVLRFIYKCNVEIIPYVPTDVEVYIKTIVLKKETKHFVLLKQRLVSQLNAEESYERANMCTINENEKLNLEEGGEVVNTIYLEYEEENQMKDFNCLGVPCKDNVYNYFYNKKEAPVYIKMAQVYVASKNILKDGIKNDGVNFLNNSSANLNNESIIRQIEEEKITVKKIKRKKRWEGISDSKERLKNLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA2</accession>
    <name>A0A4Q9LVA2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="2">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1135p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001135">
        <property type="protein sequence ID" value="TBU11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1135p0010"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="3">
        <location>
            <begin position="236"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="501" mass="58682" checksum="0A9047D186301017" modified="2019-07-31" version="1">MDLKNFFLTKIQELYKYSKNKNIGSHFNYKKILNNISELESITALSDLKQIKNIGSKTFIKLKRMLENKIADEYKNECDEKNSILTKYSNFIDEDFIKKIHCNSNTKVNKENISNIDILSIKEENVNLDENHHQINNFNYIPNYRTGGYAILKVLNKEDGISKRKIILRAQKYCDSEFDCTARYSAWSSMKTLLNKNLILKEKNPTKYFLTNCGKSLCDQLFTENSLILTTNEEITLIIDSREIKNKKDRNYFQRRFENLNIKLQTRNLEVGDFLWIKKSSFDEKILRYIIERKKGADFCSSLFDGRFKEQKHRLIMSGIKNIIYLVEGLKRQQMLNIGIEFALSNLSFTKYEGLIVIETENIDETVIFLESIDKELRVECVNTQDKSLNAIEGEADLNLHREKYDFTLEKRSSLINYDDFADKSIKTKNVKIENILYSSLLSVNGINHEKAKFFSEKYLSFSKFMYFIAQDSFINEAKDFVVNGKKLGMKLAQNIKSLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC0</accession>
    <name>A0A4Q9LVC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0684p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000684">
        <property type="protein sequence ID" value="TBU12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0684p0030"/>
    <dbReference type="OrthoDB" id="2188726at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="23747" checksum="405DAD6B074BDD7A" modified="2019-07-31" version="1">MQGYENTNNKYTTCSVKPDVLDSTEVCDSNTNIFFVSDIDNTELNNKYKIHFTQYKAINKTKLIVKISDDLEKVCNFIFRILNYRKYNYLNVMVKYKYFHKFDINIMEKFTYDCYNIGYNILFSYNCKNKILEDDFINCKKEWHPSRYETRMKVAEAEEKEAGNELVKERRRKNYLKEQNINDEGRMAWMLDDFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE8</accession>
    <name>A0A4Q9LVE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0674p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000674">
        <property type="protein sequence ID" value="TBU12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0674p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="344"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="531" mass="61110" checksum="3BB5EE5F104D9C66" modified="2019-07-31" version="1" fragment="single">MTFYSLTADLQELLRIVIFIVQTRFERMPRNGWKELHRTIMRNSAAQVVKSEENGERRRIATCLTDTCILTDTTEYINLRDKFLSTIKEISDKEIGKVVVRTRKLPSELVDSKVLDLINRIIGEYADSCVPMTITAVARIIKAAQVCYDEATRKEKPRFAWKENIEIKMSKLVLSKDLLEKARKQEKLSNSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERSDEIVSFWSTMWNKNDDAVTYDDYLIPFVSDNHPTTFHSLVEFVNIITWFPNWKAAGIDGIYNFFIKKLTTLHKYIHDIVKVICYDGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVGRRGFLAKNKLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNLLLFIDDLKLLAKDSSTLSAMTGEAKAFLEVIGLEINKEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR2</accession>
    <name>A0A4Q9LVR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0994p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000994">
        <property type="protein sequence ID" value="TBU11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0994p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="26577" checksum="F2D31AAD46ADA16B" modified="2019-07-31" version="1">MTKPIILISSSLLAVLLALGIFGFISYRSANKFIENLESDYKKISESVTFKNFAALLKKEKIAMFTPNDDKINFNVLLTNDENDRNALLEALKAQKIDDFVQIKENLPKEDPNDVVTMEKPSLPDDPGFFAKVGLLLKKKQTMVSVKKLTAFIKARLDVPHDENNTWIVFLNILDKIAVESFCVEIENKKVKSISKSLSFTIDRLDEKNTDEIADFIAYIIEKNRKKDANEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD4</accession>
    <name>A0A4Q9LWD4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0969p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000969">
        <property type="protein sequence ID" value="TBU11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0969p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="76394" checksum="0D8F1494C5278DC2" modified="2019-07-31" version="1" fragment="single">TPRSHTSQISSTETPSESDIETTGFLTPRSHTSQISSTETPSESDIETTGFLTPRSHTSQISSSKSKNPSSLVNRNFRNPRLFKTKHRNKIRSESRISRCKSIHFSTNTPINSTLNHGSFVTSEDTIKTPFDLNKTINFTSAFENFLDGKAISPEKTRIIEDEIEGENGVGNNKRNASKEEDENEEEDKNEEEFEGESKVLVKDRNEIEDEIKDGGIDKVENEGDSTDIEDEDTLCESVDYLTCNDLSHDDSSDFSIYLSSLSSSENPSLKNIRNEQHNKGLESTIESTSDSIFEITSESKEKEESFVTEEMKEKRKQRKDRKALREIEEDIKIFKELLSGDEFSDREEFVSISSENLNPFVRNYEVLKQRAERKNRILKNPKPIPLPGESTESECEISCESNSEFLSCTSGSERSKKVEKGKNIVEVVLTSPDDIKKTDNYLVRAFKKIKEKYINFCYLPAFFLKKGMCFFKDTPYDSGESTNEASEINSEFDEVNSDSSETKIVSRRDVLNFLNRNCEDKDLRKILEKEEYFIKIKNIFKKEILRNKKISNEFFLSKLEHVFKDINNFIVNDQFYSLQETVCSSSEVTSEYESCISQFKDRIESEEISSFLCTLSTNSTNYDLKPNDNSNNEVEPVKKDNVGIYLKVSAFCTFILSLIGSGLYFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI8</accession>
    <name>A0A4Q9LWI8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0532p0040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="PITK01000532">
        <property type="protein sequence ID" value="TBU13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0532p0040"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="373"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="841" mass="100708" checksum="995F25F7B8256804" modified="2019-07-31" version="1">MVGMRFNLKEEECEFIRCKGYISLYEYLEKYKNIKRSEFIKNIYILSHNDVKINCYENNLTVTEIINKCVVYLLEFDKENLMCSGFVKDMKGYGFRCVYPNTTNTLFKMRGWVDIIREMGDELTFYLFTRCSLIQNVGGKCVMLSGNVGSIFGGCRKGVVRVVDRGCMFYAHKRLIEINLDKLKIAIFGKKENFNKNEVYMVGKFEIFVRRMAKVSVKSIFGKYFKEENCLENKVKIMDCAVDCKKIQNFLFCLCKKVLGSVFDFYNFRILKGKLGILLKRNRFEIICKNDLISYFKINNLKIFEFRKCLRSEYLQRCRYFCGLMIFLFNNVFIPIVSQYFYCTETSFSKYKIFYFTKKTWDFFSKKYFLNNLSNFEKVNINCEEYSPARLIPKKDGFRLITNMSYSVAGKRSMNSKLRSIYDILKNDTIDSLKNSVIKKKQIYQKFSSYTKNIEKDNFILKIDIKSCYDNIPLKFLKKILNISFKSTKYCIRKYCTISKSDKEYKIRTHRICGKTRLPFLELIKNKTFKKNIIFYDNVFDEEFDKKKMINFILESMNKNIIKYRNKFYLQKQGLPQGCILSSLLCSLYYDWLDEKFINKVFEKGVLIRYIDDFLVITSDINEIINFLQVTQNMKEYGIEFNFGKIDSNFGIENLIKENFLEFEKIEKLRNINAINRNRNTNEQGKLEISEIKYSKENISNTFVSWCGYKINSNLSIIFDIDYDYFTYSLVYNFVKPGLSFKNKIYFYFNRHSSEIILNQNNIFLKKNIYDIFYNFYKKIKLFLQRADFINSRFLKNLRKTSIYIFYKILQRKNVNIEYNCFYQIALYAYKMARIYQNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR2</accession>
    <name>A0A4Q9LWR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0507p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000507">
        <property type="protein sequence ID" value="TBU13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0507p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="295"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="694" mass="80475" checksum="5E235EAB386C9E6B" modified="2019-07-31" version="1">MIPFRFEISFFYKSNSVTFIFLTIQTRFERMPRNGWIDLIGYYMKNLEVKPEEDGERHIITTCLTDTCTLIDTSVYINPRDKCLSKNKEISEKEIGKVVINSESHKSSTAYIMQDAQVCYEEDTRKEKPRSAWKKNIEIEISKLILCKDLVEKTRKQSKLFTSETKSLRKIMRKLNLNVKSVTDLSEALVKKNESLDVYEKKITDHESRKQFRKENWMFELFRVGSIHVVSRDENLEFILQCGIKTIKSKRCARSERTGSTQYALNKEYGNVKIDISVGPEKIMNKKIDKEILPGDGLSPVLFVLCMDPLSRKLYEKYTRDTMHNDADSHTSKHLLFIDFIKLLATDNSILSTITDEAKEFIEVIGLEINKEKSAILDTCCDDTATLYEGEDVYKYLGLIGDSKSSLTRSSFDEVQSKLIARVERLCHTRLNAKKLFGAINQHTISLINCHIGVLRLESTDFSKLDDAVRAVLVKNKIHLHPGCKEHLYFPRTEIGRGLHSVELRSEHMLLQLLDCMEKSKEISTRRAAILKVENNNKTHFAPIKSLLKVKFRSGEELYKSRKNELVSVSDSSRWLKKGNIRPLETRIKVEAKIRNKKPDICIFWIDNPLCDDLGHLKFPGTNRHRYNPLFKKKVKTISFYRRRGLEASLSVIIRAEMHEEPTLALKQANIFKSVLNILKEKTLFLLFQKRNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX17</accession>
    <name>A0A4Q9LX17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0775p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000775">
        <property type="protein sequence ID" value="TBU12391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0775p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="750" mass="89577" checksum="AB40D4FF1E690A14" modified="2019-07-31" version="1">MLSGIKTNNTIILYFYENHDYILPATDFNSNESVVYSEFINEKYKFPGFCTCKQYSEMFIWNRAEILLKFKDPLESKENSPYKIYIQSSVLSYQEFIYFYKILCEFPCLIDNFSYKKLLEVLQIFDIFKFIKNEFFDDFIRFILTSVLYSLNDDFIYNSNENVKDMILCVDLSRIVILQLFKLFICKNICLIQIGKNSKVIYSLDDYHKKILSINENFLYLDVIIILEINRMCVCCSKLRVLLEVLLSRLAFQDLFISKVSGKYFVSKNTISIFFAKLNEIIFYKCSEIEFFLKALKTSNSIHTCKSIGFIECKFNMMEEYLISELKSVKRYIIYHSLFLQSQNLSDMLPHYKYLEKKITKEIFNPYNVKNFTDRRTSEKLNMRPLTFQQNFMNTTNLFNFNFSKYPFFIYLFGEIRNHYIDVIFLTRDSREILSIELRFKKFFITGFKLSNSEIYDSILDISLSYMELNDKLLTDVLIFPKLENLNILNSNIIFEKNSLMFKENENIINFKIINSTVSKEKCFFGFLCAMINLESLNISSHRKFSIFNQEYNNICSFKFLKRIKYNVSYILTQTIPDFSSSYPIDEFTLGEDFPGGTLSKIFEPSTFNLVRILTLDRISIDKNDKLSLCKFKSMHTLTFISCKIKELNFYELFNTQENYIIENLYLKKLSLRILDLYFIRKLKSLKRLSLSIFEPYHETYKILKEIFFMNYKNLILHLDALNTSSQMDFKYRFHEEFENDKFSLVIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX56</accession>
    <name>A0A4Q9LX56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0460p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000460">
        <property type="protein sequence ID" value="TBU13348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0460p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="50" mass="5885" checksum="F957075E6061AA58" modified="2019-07-31" version="1">MDVPNELGLFYKCSVEIISYGITLYRIGTKYHKSYLKRLQIPMNVKAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM2</accession>
    <name>A0A4Q9LXM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0538p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000538">
        <property type="protein sequence ID" value="TBU13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0538p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="31622" checksum="91A4BE79FDD1CC0F" modified="2019-07-31" version="1">MYIVYTLESLANIEQKDYNDLADGLYCTEWSQHAFIKNEVVGNFKTKDDAKNLSLEQPVYWLHHEENLENDHGFATNVLQYNFSEINYLFRQLTGFITENELLENNYYFKDCRIVNIGYKKENILDNPQVYDFVDLLEGLGNIKISFGQEYHESEDRIRDNYICYLKTLEIIENFCIRFLNWEIYKIKNDILKFANIETMGLDNCIFKDTQLYNLMPLDICEKISHFEFKNIKITKSDMIFLAVPKNLYSLKVSFCNLDDDAFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE9</accession>
    <name>A0A4Q9LYE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0645p0020</name>
        <name evidence="2" type="ORF">CWI38_0649p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000649">
        <property type="protein sequence ID" value="TBU12730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000645">
        <property type="protein sequence ID" value="TBU12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0645p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0649p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="294" mass="33339" checksum="2DC5C1DC0EAE9F4A" modified="2019-07-31" version="1">MIFIFYCFLNKNLVKCAHLSDILDTSVDQNKERSGIGPFNEVSTVNIDEASDKIRDYEENPMITDKTLPEGMTSMPSVEFGKNITLLMKKTDIQEEKDNTSDILNSADYVASGSSIKPKCNYSPETCEAIEFLSRNLIMVIFGDGKQLTKTGEDEECQCTGHLDTKEEEGNADDISVGKDRSIKSKKAEKILKKNEGGFPDLAEILNKIEELKVSRESETSEYQGEDVYEKIIGEGENDCYERNNESEKTEEECSSTNEKDDSEEIEGPEEKPQTFFDWIYSFFFRLGSFFGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP7</accession>
    <name>A0A4Q9LYP7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0281p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000281">
        <property type="protein sequence ID" value="TBU17620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0281p0010"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="523" mass="60658" checksum="4A1132DD6D4B0F7C" modified="2019-07-31" version="1">MAGHNSDINKVLSNIELQERYSNSNETYNSKDSININKELVIKELPNKERINIRSNYIMNKDMIDGKNVINSKVLNEQSKVGGLPNTLFEVKNNFEVKKFIKDANTNNLYESNRNHNLSDVNNKCDNKSESDIYRIINNFTMEYNKSKEDKVLIRNFIKNNKFEEIVNTQDLENNSFTNIYEKDLLNILKSKYEINCTNIEGISDSYFIKKRINLYKTEMCRSFEETGFCKYSERCQFAHSKSELRSIQRHPRYKTETCRTFWEEGTCPYGKRCCFIHMENKSLNKKSESDLKEADTENCDSNTDKNYKEKESNIPDTISNVHKINSEYNIKATESILSSLERNHESISKFCLSKKNEGIKDDNFVAIDNSVSSNSTEIQNSLENQIESFETFGIDINDNEIPDTFLNEIEIKNIKDNSISFGKTQNNNTLSESLDKNESIETSDNQYNETKLSSNIDLQNIKPFHFTNDADIWLNGIPSLCFIKTRNRRYHGVSLQPKAPGEPVMPICDEEVAEFVLKHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS5</accession>
    <name>A0A4Q9LYS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0402p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000402">
        <property type="protein sequence ID" value="TBU13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0402p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21387" checksum="26366366AC456588" modified="2019-07-31" version="1">MIFIRFNFKDNRKTNETDAKIRNNRSYIFTLDKKKNKITLIEKRITSQDSLKIVQTEKLTKYDLLANEFGLIYKCSVEIILYVMTWDGIVTNNIIHKKTIETISFDQRRGLESRPNPENRYERANQHFFKQAFREKDGAKNSKQKINHPLFQKEKPKININEEADLEEETTVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYY8</accession>
    <name>A0A4Q9LYY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0574p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000574">
        <property type="protein sequence ID" value="TBU12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0574p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="370" mass="43990" checksum="EF73E7F04FAB9FA0" modified="2019-07-31" version="1">MKSKTILYIFLGILLSIGGVISVLWIIYNEINLVEKEVIEQLRKDTIYVKNKFDNQKEYSSHGSNCFDISPLQTKIISFLKFTNDQIIYITDQNYEKNDYDAILFCTDSNIRYLNDLDKLKNERVKRFFLEKFIYNIECQSIIGLKNSYEPHYKSAMIFLDQHILKPFKFNSTFLKLCEKFRGKRYIFSRFLEVFKISEISEKTGEGNIFIHHKEGRIHGPYYSQRNEFNFIVFFDYEIFIYKFSREKNTEDKFEKHRNLCFFKDLYAILQINLHSDLEEETKVVKEEESFSKLVSNIRNEEAYEPELNVAGLKLSVIGVFERAGCINNHTPFKAQRHPLESKTGLRIPNEKSSQFSQICCLFKKIKHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ30</accession>
    <name>A0A4Q9LZ30_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0243p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000243">
        <property type="protein sequence ID" value="TBU18379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0243p0020"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="2053"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU18379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2381" mass="281723" checksum="024C65D81A25D73F" modified="2019-07-31" version="1">MERLTKSVSFIERNQGVKKIVNTLITKDDITDAFLQNHDPFSLSEIGKTCILQWNPLLLKHESFLNLTSKVHFNEMLQIKPFEADVKSKIILIFKYLIYIMRNTFNHELYIIDPSHANYLYSYDLDISYHSFLFHNEFYNDTRYLYNDRTVAYFKSLDLNLYAKKKFEIFPVFDSNKLNLEYSYEEANLMKFKDMSRDYIKDEFINNNILDIDKFHYSLEFNLIYSEILKHEYYINSEAKKLLAIEIMANLLLAKTHFCYKTEVFLYFMNMLFSLSDLDEYLVNSLSMFADNILLLARYHSEPEECFSCKKIIKDLHDRLGSTDFAILYPTNMRIKNKLRIFCNYLYKDLCKKKEITKILQELDISNIHKIYPYACNIFYDQSFFKDFVNALLKSNITQSFNTSSLNSNFTAIDNCFKSISYENFENYEDYKKFIILMVDVLAKTMIYTFKDMRLDEQNDFAVSAYKYLYEFTKNIITLDFLVIDHIITKILEVFLYDNNAHLSDYRSKIYHNISKYYFEERKGITVESAFNIMSLISLGSGKNIKLDYPLFLKKFVLICSKNPEISLFLHHFPYIEKDLHKHIEACLSESYSLNVGSVMQMINSKDHITKFDMLCFDNLKKFFALNNFNTSLLSYLKDTDELCTIEFWYFHTFHFIHILSLVKVILNQVNKGLAKISGINNSTEIKIEDNHYLLTSIDIYYDLKRLILNKTVNNLSEIACRVKIFASFSNEIEIMCSTSVINLCELTPTFLKLLIKVNFYLEASQEILKSVLKSEDNSQEYEFIKKIIDNVALIYTKLFTTPLIPHLNTKNMSKLSKKYLCYKYESVLNSEKSIIFRLLDANYLSILKITFALFNLPTLNNPSKSKESLNFGYFLRKIPDYTTICDPNFIWLYSGSINAKTKIFEFYTGQELIDILQLVTNHLVGYYSSLKLNIEEVKGNILMTLLILLKGINSYNNCLIDKYLEMVFAFLGKNIEIFAYEDILKFLKDINASLPNVENIISKSTLFSNVLNLIKKFDENSKIPFIDIFLNDKENSLVYSFLEYLFSEMIYVDFFIEVQKRDYPIFLFVRKQIRKIGSPEAYFIEDVSKLNNYLKILRVNIEANIAYRRSVDYVKENLFISNSYLNLRASEVLLYQISLVRLSNYSNIISKKEIYSKFKILDVLKFIALKYSDHTENKNVIMEYAYAYIRYLFEDRFYLMSSLVYVFEHYDGLPGNISEYFNQKFIYTAETQIDDNTYSNLINDEDVRFNAEIVNDIIEIIKRKQEAYSLRAIALQFLTELVATFPYILHIIKNDIINSFIEDSDFMHTLSDVFTGSNCKEWDLNFRFGYFITVTLYRGSLCFTQELIKRICSIVKEKFDSSFKNYISLIYKILSSEICCCKYIQYINKSTPDFYDKNCKINLEKKKHEIFKSFLSNDILNILLLKFKEFSLTSNEDFAYFKNRVINLINIFLGYIKTGATIRIGEKNLTNSIFRFYILGSDSFMIPSPLIKCKFLEIFEIHELNKKHVEELYEHDINHFSCFKKFDYAYMIKYHNGIEGLTNSKEIGFSNPEISCIVTNFNSDYIYDIKMIKNHFSFKILDHFGQKYYVFKKASKIYCKETLIRVLLKDFYKVESSVTLDTIFTTFYEDIFLSDNFLIRKYKEILSTGESYEEYTSKKLSDIPVNYSVDPIFIYKALVYLCILPDEEYFFETIEQIKKLISFLCLKEMSSEIFCIIFDLEILTFGFENIRSSYFEKLEYLKKIIIFLIDKKTYMLDDLFIDLLFFEAIFVEKTQHCFLNSIFNSLQSNQNNPIRSLDSSEMNNAYSVSSFINRHKNTRGCILGPLLSIFTVYIEKMKIFLVKTYFEESEKLTIINCFYRELDTFLNSLDETNFYNPPENVKCMLEFFSIIKKNPMKYIFKDFLETENKFYFKVFENYIKMIVKCCQIYSLIKEKIYNDIDFKEFEQNYMWEDFICFLYNIDYSKRHINEESIDIHNNKLRHVVDLFNTIRKLSENDMGIFLKLKCLSTNIKAQSLTNITEMFWEDDLKFVLDIDRKNVIKSTIHCFVKPNKGDFLQNYWKVKFKGEEGRGIGLLYDFFGSYGKALIDEDCFEPFRTLDSTTIIVSFETEYKEILEKYYYTGAIMAKSIIYNSPMGIGFNDYVYLYLIEKTLGLEDLKIVDPTFYKNLISYRTHEDLDSQDLDFTATASVKGTNKAFDLVENGSSMQVTKNNLESYIQKMTEFKIYKNMKPYLDKLEEGFKLVFENDFKELFTPLDFRNILEGNEVVDVDEWKSYTKYIDGFDVNHQVIKWFWNFVEKTDTVTRKKLIYFITGLERLPIGGFGSDKFRENCFKIASVEGTNLLPTSQTCINLLILPLYEDENTFIEKLTFAIEYRGYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ36</accession>
    <name>A0A4Q9LZ36_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RuvB-like helicase</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0559p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000559">
        <property type="protein sequence ID" value="TBU13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ36"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0559p0010"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 10 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="56"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="48410" checksum="E00C89CF68FC50E0" modified="2019-07-31" version="1">MSTEDLKRISTHSHIKSLGLNSVGEPIDIECGVVGQYNAREACGIVVELVKNKKMAGRSVLFVGPMGSGKTALALALSKDIGCKTPFYTISGSEVFSTEVKKTEILQEALRKSILIRFKEIKEIYEGEVVDLNVIEFEDPIKFYKKTIKEIIITLKTNKGSKKIKLSPSLYETIEKQRISLGDIVYIESNSGIIKRLGKCETHKRNYDIEAECFIPLPKGEVLRRKEIIQEVTLHDLDISTSKPNGNDVVSILSQIFNPKKSEITEKLRNEVNLNVNRYLECGNADVIPGVLFIDEAHMMDLECFTFLHKAIESPFSPLIVFSSNKLKSKIRGSKNIENHFGMPKELLDRLVIIPLQKNTREINKKILQIRINEECINVSSEALTFLSDIAESKGLRYVLCILPVLKVFKTKIERNHVEEVTSLFIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ42</accession>
    <name>A0A4Q9LZ42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0501p0010</name>
        <name evidence="2" type="ORF">CWI38_0728p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000728">
        <property type="protein sequence ID" value="TBU12509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000501">
        <property type="protein sequence ID" value="TBU13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0501p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0728p0040"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="17750" checksum="633D691BB742768C" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ82</accession>
    <name>A0A4Q9LZ82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0541p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000541">
        <property type="protein sequence ID" value="TBU13065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0541p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8837" checksum="C7C14206D2E48DD7" modified="2019-07-31" version="1">MECVNIAYIQSILIKKIVEKKSFERQRGLETEPNAEEKTKTFFKTASRDEDIFKCLKTKNITRLIPKGGTMSEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZF2</accession>
    <name>A0A4Q9LZF2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0507p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000507">
        <property type="protein sequence ID" value="TBU13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZF2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0507p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="30409" checksum="8339750AB5FC9E07" modified="2019-07-31" version="1">MNGSKLLIFKFNIINCSLIVALLGNLKKCFDTPFEYFFEICFLTFSIFLMTKGAKYSAVSLTGLLILILSGYFFGFFNKLQNTFKENEKSVNLILPEVCQKMVNLIERNPKVIWKIIFVVCLILAFLLNFVFKMNHFVIFGILTIVAYREIFHEKALIKFFIEKNYFRRILFVLFVIFAWYLSALVPILLLSIICCYFGALLFLSTVELLFNRNWGFKNAILNFNIDQVSVIGWGLSIIWFILFILALSFQVSTNISKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH0</accession>
    <name>A0A4Q9LZH0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0214p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48386" checksum="D29C922AECCF69E0" modified="2019-07-31" version="1">MNNSPTNSTSPSTTNSTPQSQQQSQQQSQSQHTQIQTQINKKLKKALSLTKKHFFPFSLIFSQDYTSAANLYNEIANSYISINNPLKSYKYYNKASTCYLLDNEKGLSMHCLIKAGEIIYKKNKILSAYTYIKGGDIGMEIGSYCISGGRYLEAGRIFLEIHKSIDTGGDIGYDIGCESEGYESDNNNNNNDISSNNINNTSTTDNTNNPSITNPPHTPSSITSTNHFLFKSLLAYEKGVMAYKLANMKNNLRGVLNELIIILLKLKKYKKAGNIFIKMICDERKYNNSFYMLCSVMCYKVSKSGVYCENEYVCNGSRERGSILDNGKDYSKGKDYIKDRGSNNIYKDTYTDIYKDNADIYGDEEVDIGGCVLQLEEEELKVYESLGTESYEEVCDKYFRCRKVDEEILLLFEEVERINRPENDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP5</accession>
    <name>A0A4Q9LZP5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0201p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12659" checksum="68279EB70B79DBC3" modified="2019-07-31" version="1">MVLLCGKKKKETIIKVKNKKYEENTSIKVHRSKTLGGNFENIALCWSYSEDEIIDTYPDICNFFHTVDRDRIERVQQTIKNCEDNLVTYDNYFIPEVSEYHLTFSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX1</accession>
    <name>A0A4Q9LZX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0339p0030</name>
        <name evidence="1" type="ORF">CWI38_0470p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000470">
        <property type="protein sequence ID" value="TBU13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000339">
        <property type="protein sequence ID" value="TBU13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0339p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0470p0010"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18450" checksum="4AEC0656E1E56CA5" modified="2019-07-31" version="1">MDQIELALNKEKSDINDQCFEDTSALLEEIDVYKYLGIIDDTDKSQDLDDSMRGMYKVFVPSCQRLTYAFATFLVPGKINKASAKRPAIIKKNLEEAQLAKLYNKIEKQKIHSNVSFRELKKANIKPHEENVFCYIQIELSHLVQEILKNEYAEIKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D3</accession>
    <name>A0A4Q9M0D3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0147p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000147">
        <property type="protein sequence ID" value="TBU20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0147p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16854" checksum="3B1ADD959434D3E7" modified="2019-07-31" version="1">MNRFLTSKEYKENKTSVIDRKTKLIILNHSGTGATGRNQLSGSNQAGLWVVTSKGLFYDEKCVKMYLNQRFQFVTYHMGYSPLNKIHSQHVGTSFLLKHTRIDNIETEKRQQHLLMLFGTKNEQNFYYLRLSTTTLKIIIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G0</accession>
    <name>A0A4Q9M0G0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="16">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">DNA repair helicase RAD25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RNA polymerase II transcription factor B subunit SSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Suppressor of stem-loop mutation 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CWI38_0364p0040</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 27">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="PITK01000364">
        <property type="protein sequence ID" value="TBU13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0G0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0364p0040"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="212"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="24">
        <location>
            <begin position="428"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TBU13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="656" mass="75705" checksum="4293B885755171A8" modified="2019-07-31" version="1">MKEMYNMCPLYVNYDGLIILETFSPLFKQATGFLIAISEPVSRPSQIHEYRITAYSLYAAVSVGLTTNDILTTLERFSKNYLSNGLIKYITECTESYGKAKLIMKQSRYYVECLNLEVLRILLKDAVISSSRLKNQKEISTEDNFATEEENFKLFEILSHDIEKVKKRCIEIDYPLIEEYDFRNDARLPDLTMDLKQSATIRSYQEICLNKMFGNGRARSGIIVLPCGSGKTLVGITAMCTIKKSCLVLCTSAVSVEQWRQQLLFFTDINADSIARFTSEKKERFTSVGGIIITTYTMLAYSGKRSYEAQKTMDFIKNTEWGLLVLDEVHVVPAMMFRKVISLVSHHCKLGLTATLVREDDKIEDLNFLIGPKLYEADWQDLSTQGHIATVECIEVWCGMTAEFYREYLQQSSRRRRVIATMNPTKFQVCDYLIRKHEAKGDKIIVFSDNVCALKAYALKLGKPYIYGPTGQTERMRILKQFQTNPKINTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKKRNDPGFRVFFYSLVSKDTDEMYYSSKRQQFLVDQGYSFKVITRMKQAEENIDRVFRSKNEQRELLATILLTSENEMESEESEDTDRAYSNKSTLKNISGGENMAFIERKKNDRHFLFRKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K5</accession>
    <name>A0A4Q9M0K5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0119p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0K5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0030"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020555469" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="286"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="437" mass="51075" checksum="C2885EC3BDF1DA3F" modified="2019-07-31" version="1">MIFFILFFTFLQTETPNIYSYKQINLDNTKDEPLKANFFDCKNTKHEKCDENNILIEHLGRTFTLKPENEKVLPSIISLLNKYKAPPQNIKEIVENLTSLESKEDPEIVSIRSGARSFAIYFVDSNEVDKITPSTLPNISIFLSSDKKLAETLDTPFPGIYGFNASERTHYRMKPTESYLSNIYTILIPILEEVTSETIKHYELCQLPVFYIFVSQKDSESLMKDLKPIFLKYKEKAKGAVVFYKQEKTNLKHFGISEEQLPAMINLTNKKKYKQVGLTKENTENFLENYFSESLTPYEASGEVPEDNSKRNLKVIVRNDYKKYYEDIKKDIIIVFHSPYCRYCVELKPLLEKLADLYNKYASKKIVIGTIDMVDNDMPEFTIHGFPTIYLLKGKTREAILFDQQRSFNNFIEFIHQNGYNKINLNKYLDKKEKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M143</accession>
    <name>A0A4Q9M143_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RdgB/Ham1-like purine NTP pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_2139p0020</name>
        <name evidence="5" type="ORF">CWI38_0076p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002139">
        <property type="protein sequence ID" value="TBT97671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M143"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M143"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2139p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0030"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT97671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="244" mass="27509" checksum="DE6430573A60E3B8" modified="2019-07-31" version="1">MKIYFISSDIKKYKEICKLFPFEIFHKKMDIIEIQGSMEEIVRDKAIRAYNSILGNKSSKNVGNSNRDNEDGNRDTENNKDKNIRAKDIDIGNINTTTSIKNVDNRDGEEDFAVLVDDVSLEMKGLNDFPGPYVKYFLGIGLEKIQKIAFFYGTECTAICSLGLVYKCGGNVCVITSEGRTEGNIIVSDDLGTNEFGFDGIFQPKGYQKSYGEMTVEEKNEISHRAVAVMHMVEKIKDLGIFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M152</accession>
    <name>A0A4Q9M152_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0293p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000293">
        <property type="protein sequence ID" value="TBU16707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M152"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0293p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="244" mass="28873" checksum="33E110FD62E99306" modified="2019-07-31" version="1">MFCASMKDKRFLKVSKYSIFLSFILCSMMFCFPIGRKIIFYQLDNATDGHEYLNSTVFTNCRIESHLIKLKPNELYYENNFERRCIFNCLKDSIEITIPNIETSPCNFKENKESEIETITPNICSIDASAIKFLEGFLSSYHLLQENITLKYFFKLLYLFEARNIRFDQKFVKIIEILVLSLLKTGKSDADNFQEEMVNGFRIDLLSEECSFFVFKILFEFLFPSLKIKDIDRFSSSTYMHIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M179</accession>
    <name>A0A4Q9M179_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0327p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000327">
        <property type="protein sequence ID" value="TBU14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M179"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0327p0010"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="40156" checksum="20FB58976ADD8558" modified="2019-07-31" version="1">MKVRRAYFTLFIIFLISELFQKILLFYSQKNVITECTETKNYILYEKRYESAKRSIVGLKNDNFVCYFNSLIQALYFQNDFMKGLFLYEHTKEQRCIFILKELLEQMLNDRIVNTSVYLKEILELDSNMEYFKFGCFEDAGTCLDIIFLRILKEIDVKKFSDLNNVTNKYFPINLYLFQMKTTYLCVECLEKNIIYGDNYNLVLYLENSIQESINKSLNVESIQCYKNKFKDEIHYAKILREFVNLPSSIIIKNTHDPSSNGNVLIDEEIIVQNQKYSFKVCVFYVKDLHYYTVAVLGNNYYELNDNSVKKLNIESIENLGFSDIPDILFYEKLNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M185</accession>
    <name>A0A4Q9M185_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subunit 1 of chromosome condensation complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0067p0050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000067">
        <property type="protein sequence ID" value="TBU20464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M185"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M185"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0067p0050"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="871"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1044" mass="120086" checksum="B1468FDB75AB3F98" modified="2019-07-31" version="1">MNSSQEINSLLKNLTISSKHTETLTYLKENYNPDTLLLLCHKLPPTNIKAFQYIISITKTDIFLPKIIFCILERTLDGSINGSINRNIDGNIDGSIVSNNVNKASKVSNKTTGGDYELRILCQQKLITYIQSNENINDTIITHIVSLLGHEKSFSLVLDLLLNLPFLSFNFIISYLFNTSNNIFIKNMCLLLPSLICHQLVCIKDLEDLKFSENCSLRGCYLECVYEELKIKIGNKKCFNKESEIVDDTDDRIDSKIYSKIVNRIDSKSELGNKINNNITEDNTINDIITEDITKDNISDNTYHYLQILYESLHDTNFLIRSKVISIFCYIPYSLLCKEYMIRICERIKDRTVVVRKKAILFFINILKNIKNMGGVVEGGLIDFISVSVLPNINYILLCTLKPEIEDILCLLELLSNYTKSVKFTYGVLFRELQNFKENKKIIGALNKLLQEKSNFQIVEFLSGFVGEGGCYWLENVIREIRGVNTRVISYLINECKKILEKNENLNLCFDRSFFELTYLLSVFVYSKPNLLVDCYGILVVKISKVLFSSADVSSLYANLCVYKNILRMFMHLPCINEETLVLVSKNLYKMNFFDYQVVDLTLCVIYKSECPEKYVKKALNWLVKKESDSLKILYIIGSVSIKHSKYIEGVITNDSKIKGMGVNNSTDSKLRGTSNTTGVNNSTVKQEGVSNSTNEQDVVSNSTNEQHPLTNSTNEQHSLTNSTNEQHPLNNNYIEQHPLNNSTILDPNLSILSASFMEENMSFIDPDLTRRRKSIQRKKPTNEIPEYLEDLIFYLKEKEIFFGENVFLNQFIKKILKIIKNHQNLPETPYTTHFINTTHLTLFKCMTVSSELFLSNLPFFINSLSHKNFLVRNNALVAFADYIIIYNSLIENHVYLLYTLLSDTVSVIRKNCLLVINYLVNNEILKIKGYCDIISQCLIDSNLEVQKVAEKVLNEICKKESIYGMIVVECVFKNMDSRIYKFLGKIECKERIREGVLERIKGKGGEGENILSIYFYISTTIWIVNNTNLSNNIREYFNTELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S7</accession>
    <name>A0A4Q9M1S7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0235p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1S7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0040"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="241"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="44193" checksum="FC2B82E5D0BD1169" modified="2019-07-31" version="1">MNPFPDTTLLYILSQSYGQDFFDYQKIAIKLNFLTVSYEMTNLLLSFAISAFFLSNFFIDFILNCGEKLFQKSNKKDIFGLPIKEIFLIFVLYIFICFKFLIIFIIRYITGNLFSETATEYLFEEINIFYFFFPLLMAIGVLIPKKFHKILIICYFVIPLGFNIHDMIKKNDVNLNIFEKVDIEKLEKTLKDTVNKYNLNGKIYQEKNDTGLPNGKTCGHFNKYIIFLYGRDPEDTSKICHGILAHEIGHVEDVSCLKKNCFNIFTTLVECSVALLTYTNILPLYSDKISEFTAFSILSLIYIQTLHQIIETSHNLVARRTEVNADKFAKNLGYGENVIKELFYLEHKSCLYPWNSNLYCLLKKVHPSLYSRQKWLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V0</accession>
    <name>A0A4Q9M1V0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0228p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000228">
        <property type="protein sequence ID" value="TBU18859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0228p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="93253" checksum="73D2888DA150FB96" modified="2019-07-31" version="1">MFKTTSSDIKIYFNTICRVPNIFLCFYMFKYTMANKKYILHFYNELENISEFLNDLKLHEAALSKFINKDYKCYQHTIFTNCYKIEIFSENIFPLRFNSKDSDTEINNIYIKDKILNHNEFIHFKYFIRQFPALKENLSLVNLLRFIRIFDVFEFENDKESKLIIEQMIEILLLSIAYNISFKGVSKVSEEVGINFSVSFLKRFFYKILEIFLFNREFLNTIKLKNEIDTNICDVNLKGIFDLNDFLWFDTELFREISKKARISIEFKNLLTYFFHYFSIKKVVFSGIHEYTNDYLSVCLLLLPSINEICLVSCSDITFLKFLNKYEVFKSIKTLAIINSRVDICSSDFSKLIILFDTIIFLNSNFFKSISINENIFSMTEIITKFSNEISNNNKRSSFFHLRNNTKYEINTKDYKFSYLYSPTSFKNLDIKVKKDSVRIYYSVNIEYDLIKFYLVILNFEEIIYFDIYIENISIKRLIFKELNIKNKIKNIYIFNSKITESFLNDVLFFPNCIGISFEMCYFEFDNLDFHFKKNLSIIYLKIDKKCEINYFEKILEFIDVLDNLESLNLNYNDLHLLCINLYGNSKFSWKKIKRFELYEISNDENILPNFSFFPNIQELVIGKNYQDGMISHIFSYKNMENIHNLEIDSYAIGLKDRAALKNLRNLKNLRLEYCDFENIAFSDLFDIKDEYFIENLKLSEIILEKRDIIFISELKDLKSLKLNFLFFKNFSYLTLKMKCFKHPTKLELEINIYWSLKNKLCYFMEEFGPKYLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K0</accession>
    <name>A0A4Q9M2K0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0004p0070</name>
        <name evidence="12" type="ORF">CWI38_0006p0060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU21000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0060"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="380"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU21000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="624" mass="73475" checksum="4BA9F200DFB5169D" modified="2019-07-31" version="1">MIFYFQYISTRSGKSIFLVFEQFRYVFNIFEGFQRVSIESSLKLSKLTAIFLCDTNNVPPAVALHLTLLSNIPVICSSKQEILFRFSKNISDSAKNQKLDFICSDIYDDGFLKAIKISFDDQNTYILQLPEIRGKFLFEKIKKYKIPQNLYSKLIEKGKIVYQEKTYFSKDFLEESVIPKNVCILFCNKNIQKFYEKVIEFKVDIFICFFEESLKYFMKRINGEFYLLNDNFFVEFPSFYDVQLSLNQIDRNFLLPVFCKSNLKMKKKLKQISLENQMKTELDEKKFHTKYQYEQDFDSNANDRIENTRKFNANTTYYQIENRSTKEILESNDKLIFQKNNSYEVKKNPQIKYKEAKNVQRPHSILFLGTGCAIPSKYRNVSAIIFECKKSAFILDCGEDTLFQIMRIYKNLDILKKIKAIIISHPHADHYLGIISVLRKMKNVLIFGPKFLSDLIELYFEKHTFEIFDIENFFNSSLISSPFKSEEFELTFSRADHCKNSYSVRIYTEFGSISYSGDTRPTKDFIFLSQNVDVMIHEATFGEEEKHLALRTKHSTLDEALDVFQQSGAKKLLLTHFSNRIPKHVECIGINSIICFDFYRHIINEDNNNVSQKVTKFFKSLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Q8</accession>
    <name>A0A4Q9M2Q8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0096p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000096">
        <property type="protein sequence ID" value="TBU20288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Q8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0096p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020420467" evidence="2">
        <location>
            <begin position="20"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="518" mass="62199" checksum="AAC3D468558CD86A" modified="2019-07-31" version="1">MHLFLFLFFLISLCFGSMSEDPKTNNEACHSKRDTSDSGKKNKSEYNISKDFHLIVMTDYQDAIDTISLKVPGLKDILRSYLEKMEDLILECINKTLNNQIEILKKPDNPNISKSKIYEAFYLDFIENLIFDLSSLTEKSFYSKEDLYDFKKTVGGVFKQIKHKIHCEMPYDIARIKAANKAHVYNETKKEALKLVSNIGKNNDTKKILIEKSFEIFKSSLYLLNKEILGSLFFKSKINDDFINKEVENNKFLKNIRTMHEKNGWPIPNYYTMSPLQKNKEVFDLFFEMLFKFMTEYYFNKMFPDIFTHKRLFLFWAHNGSEPGVPLSIKTRDNSFLPVVFYDREREYLYLAFDVAFCRNLYLYFYFRIEEWLFIFIEQLHFCVGKEKFVEIMKMDLPADIVERRKQTNTVFEKIYKDRKIFCGEIKSFLIKFMIFFRYYTYVSFCIYKVQDIDLSDISNKFFKKHLKNKFNSEHEEVRFISKMKEIVLIYFMNFFELIVEECLGDDCVKEKMVYWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M313</accession>
    <name>A0A4Q9M313_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0048p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M313"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="258" mass="30212" checksum="0D169D286B2D38F5" modified="2019-07-31" version="1" fragment="single">MSVESDKLVEALRCLKLDLLDKKYKYEKILKSIYLLSNHKFKNKNTEEYSPKNLKSNEKFKFYREINGVLVSSDCDDIVSYCKNRIKEMDNELLKVDELGLGMCVIKSDEMPEESLNKIKTYCLLKFWGADGVCQHFGKSGKTVDHLANRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDITLIEVGITSQDSLQIVETEKLRKYDLLANDLDNSYVMTWDGIVTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M355</accession>
    <name>A0A4Q9M355_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0128p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M355"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24412" checksum="D8D9750080252AC5" modified="2019-07-31" version="1" fragment="single">LDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDEELTNNINEATDLEQETVVVKESTTYFTEESSDFFTNEDDLVYDIISKPHFICEIEPEEEEDFLDQIIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M368</accession>
    <name>A0A4Q9M368_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0151p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000151">
        <property type="protein sequence ID" value="TBU20011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M368"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0151p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="574" mass="66300" checksum="B9D47653EB97FB91" modified="2019-07-31" version="1">MEKKTKKILFAIVGFLSLLVIVVFTLIYLNANQISKKFMKEFEDFKKSKEGATILREFNDCESISTLFTKTESNISVPPISFCIKNIESIKEIIKMIYFPTRDAVITPQAALQKYVTYFENLKIVFLPYFIEVNQLKAFMKSYEPSSFASMGLRFVKNGNAIRFLQKYIGSLEKIILNFKIPFGYLEQCISNNTVHIKSTHIPLSSPTETLKFLTENNSTVKIDFKNDKRMDFLLFFMYKSRKSNIKECFLNFTDWVVKSKGLPNILNFFVHFIITETPDFILLPITNFISSDVDTFLSSLFCLKQQMISSIEKTNDLQPILNLGISMLSSACDALWKKFYENKDNILKDLENRKPPLLILKSMFENLSNKTNIFNISNSLQIDTGIDSEYERLLEDRKEKIRKKEAVTTTSSGTIDEYIEKFLINFIKEYVPELVQNKDEPLTKTEAVSLLEGKINECIGNFLTVFIKEYVPKLVKNNKKDLDKTKAVSLLKNEIKSKLISLSGESIGNFLEFVISTLLKLYEEDINRSRKDGSDPSQENDNEIFEKQLLSALIRVLKKVVGQNWHIFTSFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3B0</accession>
    <name>A0A4Q9M3B0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0139p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000139">
        <property type="protein sequence ID" value="TBU20061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3B0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0139p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="772" mass="91366" checksum="C23A33EF54F2049E" modified="2019-07-31" version="1">MTFGVVLKLLNIEIGNYIRLILFLLTAKIISMRMAIEIHFYENSECSLPERKIYNPFNSAIDLESPVKKYKSFIFDPNTKILRTFLIDLDMFFLAFLNEEEIHEDQQHIIYVNNNLLSLHEFDYFYRIVISFPCFVDYVDVRTYQLIFKIMNIFKFKKNKFYQRFIQFISVSLIFNPLVTKKWNFLLTSDICSHSSVLSKKIIVELFKSHFMSDKTFNKITNISHAADLTENFDIDLLTPNQDFLYLDGDIIQKIIEKSRNSTNIIKLLDAIFRIHIFKSVCLFNISYTKEYNKFFNLYLFKNLDEIFLLECSNTDVLIGNIYNGKSLNCIKTLSIINSKFAIKDEISWLKTLNFEVLNYVDTKRDFFTLFTAFESDSSVQSIVSIFKKEIYNKENESTIFYKNMNKTCCDHKTRIYLKSNQDKTKINKFKNQSFPFELFVYMELSNSFISLNFYVLNFKKIRGIEIEFTNTYINDFNLLDSEIFNNIVGMKLVNSTISEAFMSKILLFTSLRKLFLYSCTIVFEGDRIAFSENTQIKKIFFGVSCVKNNQKFFQFLNKIVELKELIVLCFAIDTNPFWSMIDPRGESLCKLSILRYSVKYNLSNAIFKFPLLPNLLNLYFGYEYPEGTLLRFFLNNHLNNLKKIKLDRIKIGKMDRQALGNFTNLLYFYFSDGCIISEISFSDLFDFNNEYSLKKIRFPKIELTYRDLCFISNLKSLRNVYFESLELKNNSLYFFKTFSGMKKIEIGNIQVFRNKFNEEFGAGAKRSHYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Q6</accession>
    <name>A0A4Q9M3Q6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0018p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Q6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="736" mass="86073" checksum="F8C74DAC8011F213" modified="2019-07-31" version="1">MQLNNDSDLEVHFLLEQHDLEGFVSAVRFVIRNMLNIASVQLNFRIEIHGVIFNIWGFTFELPIDAVKATHDFSVATLTDSIKDPRLLIQNNCFNSFKKLSYYCLSMGVWSYFENNKEVLYANCFKYNVKCLKMLYSNNIFGDDSKFTEFKNEATSAGYYDAAWDMEHEIISVSSSDNENFTEGADNLHRSGRENKNGFLRKNRYRPYVTHGRQHDSQRTFSENRDTERSSVFLAPSGSNYIEKQTDLGINTYESGCWNRSPNKHGVISDNETTSETSIKSEVDDRSIPIHSYSDYIENPKESSCKKMPRLSELQVETTNESFEFKLILKKREYLQRNINTKGESYAVFMDTNEDICFADIQAFISGDFYIDPRASLNDLRPFLEILDFVAEKEERFWNRPENTRMMNNLKEKMLACISKINFCNDDSPILTFYTGLIHIKHFIRNLICDDINLVKNSCLWILLLKFVHSLSIIPIKNIYMNSRSYVGTSYLKYIDFEAYDGNTHVNYLIKKQYEIFDAIARHVFLKTKIFPESIFMLDYIKNSLWFCNKDIHVALGKYIGLCRVITDCILRLDPRVICMYILRISEQKSIDWNSINFRASISSFFINLFSGSINNGENNLIRDFKVIYKAIILGYVDFFRQEALQQEFQSSKNASFLKILDFEIRKFLKKLEIKRLLFGCTAVKHLENISEAFCVLFNYYIKIGLNNQAYSERYMKRSLVICEKKIIFLNIKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3T8</accession>
    <name>A0A4Q9M3T8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0117p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000117">
        <property type="protein sequence ID" value="TBU20186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3T8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0117p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14823" checksum="52C50B38822C5D0F" modified="2019-07-31" version="1">MLYYMLLVSIKSTETGPQRDMNCMRNNISTEEMLESQSIQQIEEEIIFFYCSKEELTAFDAKSNSNSSGIDKEVIENMDPSEIKRSCLFISSLDSIKRNSALNPEIPLINIISLIEKKRDTDKSNQNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE1</accession>
    <name>A0A4V2JXE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1199p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001199">
        <property type="protein sequence ID" value="TBU11452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1199p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="74642" checksum="C3F9AD4F4AD0F355" modified="2019-07-31" version="1">MPQEISDIFIYKESLLKSNILGSTIFKSYFVTLTNTSINFYSLIDFTKIITFPLIKNIENKNSFISSDNEILISSEDLNFIYKMIKIDLKYKLGNVFTQCSFTDRFFITAVDNTDIFFYDKFSDFKEELIYKSKNNSISSLKAISDEIIIGTNDGKIIILNFKFDSNQNDNKLAITNNKMLKVDEEYVITGIEHIEYNYYCCVSSSGRAFFFDTKLCSILQTITVSKGPLRCLVTGNDFIYISGDYTGINAYSRVFDYYESTENSKIRKYRFFAKIDTHYLPITNLIYNNERIISVSQDGLINLHWLCEDKFLFRKYYFGKKICFSKKYFTVQNNKKINFYKFLLPNKVQNNKKTEFNLINLSNKNIRFDVKFKSKSNIIDYSYYKKYLVISQNDKSKLYKLKDKKFKKVKSFLPGYQVSFSENLLVINTFNGYIIVYCLKSKKEICRIILDEYEKVLYVENEYVVTKSKIYFINQELSENSKKIKNNENINYICDYSSLLDKEYEMDLFFNHKNYKIIIYHLKNYSYETKYYISIIKSTKIKNDEIFKLELKNIYKIDGGFYTENGVYFYNHSYLFYCRIYDDRIDEFKRIYVGEILEGITIINNQVVGIKSSYTKIFEGIKEKYGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG8</accession>
    <name>A0A4V2JXG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative IKI3 IkappaB kinase complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1050p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001050">
        <property type="protein sequence ID" value="TBU11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1050p0020"/>
    <dbReference type="OrthoDB" id="2190800at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="52959" checksum="6DFF15020B60BC56" modified="2019-07-31" version="1" fragment="single">MENFFIRNSKIVELKSKDFLYSNKAILIDNKILSISDLEIFCDLETFKSTIIHSNNSQKEIKNENSKISEIIKSKKSYEENMPNTELNSSLKIDYFFNSKYFYFLISNTNSIFLIHKKLNKITEIGTFEHKIILCRFSPSQKYCVILLQNKEIYLLNENFDILKNTHILSDTILPNKYIDTNHIFTTEETFINLEWSDQNKFAIIFNTQILIYNTELENISVSLNFKPTGSISWNSKYNTFAVSSPEIIYFIEPNGLLHHSPLKTHNTHISYIDSNLLLVFNHLKEFNEFKIFFLSNFKWYLKIHKFVPKTQKFLSIHKNIIFLKSENKIIKYYFYKEITSQDTQFGVINGKNIYFYNYQNKIIPPPFSSSSISLSYNVIDICFSNHKIFVLTSTINSEDSNTKYELDSNNPLSIPFVAAINSEDAKTKCEVDSKTKSDSISSVSTINSNDQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI6</accession>
    <name>A0A4V2JXI6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1002p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001002">
        <property type="protein sequence ID" value="TBU11872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1002p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="87149" checksum="0081A1B63A6854E1" modified="2019-07-31" version="1">MEKNEKNEEEEADEEFEEDYEIKILHGYENNYYDISKPFFIYSKENLVNFEVLDSILSLNMSENKPKEGIIECRYQLSYFLRLIRDVTEVTNNLNIQQFKYILMTLKFLKAVENKNITKLLQVLIFNNFFYQKDYKLRNYNLHLIQILNSSFFTQIDFHLKKNIMSSFLNSLMIRYDFYDENLIIFKNSKELFDYSMFSEHIPYKNLMINNFDAFCSVENILRDSNVLIIFQILLKEINIKSLILNNFFRHLDPDENFAFLISKIEIFKAFTISNYKIPASPFFLFCLIVSINNNIEYLRLENISYCRLNLRGLLEGKKLKGLILSKIGLTENASLINESRNVYETIEYIDIQGVFLNHSIWHEIFQYTNSSKIILHFNNSDIEEIFINNLKKFEIQKNSVLYLEIKFNSSVLPKGFCNSLIHFKNLKTLKLDGYIIYEDTESLLYKAIYYMKELKCLVLCQNCRNKKPYIFLLQNPKIDCLDIQSTSNNNDAIMIEFFKLHKSMTRISIKDAKVSSLCLKEIFKQKNLIHLCLDIDILPPQVDQESLNFKSKNIHNLDLCNNTLKYIEGVDILSKLYRVHTLRISKCNPPPGYLSKLNKKCNSYVKILTYEYGILDFDDLNRIGKFENLLNLSLLGCKFEGCSFFDLLVTSCKFFKSLKTIDLLNSNIRMKDFQCMKQFTKLKRVGCSFTGFNLLTLKNSLASLQICKLKFHTMLEDSNYKEFCLYLNESNIYILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK7</accession>
    <name>A0A4V2JXK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0840p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000840">
        <property type="protein sequence ID" value="TBU12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0840p0030"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38361" checksum="53529EB07988D40F" modified="2019-07-31" version="1">MIEEIDIENSNSSDFQSYIPKETTKNLEVDDSAYTLLEYISLDWPAQSFDFISDYKIVTGTNPINDNPKLITLDFKKCDFDKNPNINKNLKIKEHQTNYSFNKIRYNLYTEYVQCISDNNLCFYNSNIKLIKDIYIEQGISYGLTNTDSFTVIGSKCGELLFYNDLFQNITNIKLHNGSVESIVCTDGCIYSGSTDKKVISYDFKSNKPIFELNFDSEINALDFSANTLCVGDDSGIIRLIDIRNTRNIESITWHNTPISSISYVEKDVFISASDEQVALWDTSFEEEWEYHKYIYFVHQGNTFYKDVRVCRGNSNLIFTTALEGITLFSPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR4</accession>
    <name>A0A4V2JXR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0624p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000624">
        <property type="protein sequence ID" value="TBU12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0624p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020612891" evidence="1">
        <location>
            <begin position="19"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="607" mass="72639" checksum="0D54797E757B66BE" modified="2019-07-31" version="1">MKLILKLLLIFIPKKTLCSWLGHLSDNSQERDRFEINEYSNTFSSESLFLIDEEEYNDPNLESGFENYSYTYDEGFCLGSEKTEPDPLFADVLVDFSTSEIEKYSVDYSENSVQPNNTSSDNTLQKGKTSITNKCILKNVLEGKVEYVQVSNKQSHNYYSKSDLTHKIPQENENRKENTVCGEDIEKSKNIRFLQKNELNQKKRKDTLLNLNVKQNLNKLHKFPPISDSDKIKAIRNIGYLHETIEEIISKNTCEDISSNFLRFAEERCFENLLSRKIHSMQYKRIKRHEDLIPYFEFAKKIICFEKKNMKNLSNEQMNNFLRELYLRNFEENISNLKKYRILNEIYFFIYSYNKGSIVVKKNHVVYVSFMFKLLEIWHSNLVDFVGLKNIFCFKYNSFVFSLRFIFYNLLFGIENFDSRKHFYIIIGSLIYFNDIGGIKRLRHKKKIYCLQLNILCQCVFLCDFNNKYATSAIEFYKSNVMSSSESSFSNQKYFFKKFFLNLKDMDLIRQYIGTYNLMKKISNFSKIYSDFNEDLIKISTKYDNKEKIEIENEEFIEVLFRLETMIKWTHSKIIYSHHKLRDNFYLERSRKILKYVHYLLMKLFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT0</accession>
    <name>A0A4V2JXT0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0550p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000550">
        <property type="protein sequence ID" value="TBU13042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0550p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="61463" checksum="82586221552A0EF8" modified="2019-07-31" version="1">MSNRTVNNKIHLRLGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKSKETSTRRAAILRENDNKTHLALIKTFYNVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWRAEGVVNTATPTRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYNLLANELGLIYKCSVEIIPYEITWAGIVTKYHKTYLKRLQIPINVEAYIQSIVIKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKEPTPPLKEVKNEEDSVKQVNSKNILLLILDDLTRPEEPTIDINDKSDVEKENKVVKVMEEISQPGRVNQTIKRWLAKKLHETSVRKLIEYRKNVVYSYKRTINSFNNTISGIIIVENEASTMMPAIDIDPDMHFKNYREIIIESNNSNKLKRDLSIKNQVLIKKNEFDRNTKTKRAPFDSFYDNSVFTIAGILMNNMIEVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU8</accession>
    <name>A0A4V2JXU8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1144p0010</name>
        <name evidence="4" type="ORF">CWI38_0504p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001144">
        <property type="protein sequence ID" value="TBU00004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000504">
        <property type="protein sequence ID" value="TBU13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1144p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0504p0020"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="185" mass="22008" checksum="9101AF43505FF2C5" modified="2019-07-31" version="1">MKFGKSGIELLNDCKMKVLTPINKISLQKIESENNLLEEKMKEVREKAERNEVSEKLSTDYFLLKKFKERNERIRIAYQFSRCIKIQNNYFKKDKIQHLLSDEENKHSFQSKQIFDEYFSEFGILDFIDEDPPLNNFVQILTLDNCGVVLDGNDFLEMKKNKLYFVKKKNIKHLIDQGLVKMINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX1</accession>
    <name>A0A4V2JXX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0430p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000430">
        <property type="protein sequence ID" value="TBU13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0430p0030"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="17289" checksum="05437EED1ABB0E11" modified="2019-07-31" version="1">MNKYDIYEDKYEDEDNNFIRYKNLNCNNKNVKFKNINDYEEDSKDIFDENYKNNCEEINYQNKNVKDERKKYVQSLIYERLFESKKLPYNYIRKAFFSIISYEFKEIFSCSDISQILVEIYVLFDNCSLNSKEIFFYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY45</accession>
    <name>A0A4V2JY45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0222p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000222">
        <property type="protein sequence ID" value="TBU18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY45"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0222p0010"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="228"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="58131" checksum="E1F63AE07028A2C7" modified="2019-07-31" version="1">MIIAMVCDYFFPNIGGIETHIMCLSKELVKRNHKVIIITHSYDNYKDIHYLKVDKYNYIKVYYLSLPLVCQNTTFPSLFSNFKHFFEIFVSNEIEIVHGHQSMSNLSIEGVSHAITMGIPTVLTEHSIFETGGIENIIVNKLCEGILKNIGAYICVSYCCKENLIERFEIKKENKIFVIPNGVKSKNFRCKKNRNKIQRQKCGVTNFIHKNSKKIAEPFELIKHEDNFKSFFGEFEKRIKIAVVSRLVYRKGVDLLIEIIPMVCSMTKNVDFVIVGNGNKRENMEQMIDDNKLHNRVLMLGELDNKNISGVLQRCQIFLNTSLTESFCMAIIEAVSSGLIVVSTNVGGIHEILPDEMIELRMTSCEDMVEGILKTVKKVEEGEFGCGNCNKLKNINEIFENDKCSLEKLRPNDFLQSKEIIYCKKCSPIRFHKFVKKNYNWKRIARKTENIYINAFKNNELNHAVTYSDTFGSLFRFFFRFLIIMEKLIYFYLRWKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY75</accession>
    <name>A0A4V2JY75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0139p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000139">
        <property type="protein sequence ID" value="TBU20063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0139p0060"/>
    <dbReference type="OrthoDB" id="407509at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="385"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118462" checksum="E58CBFD530ECFFD1" modified="2019-07-31" version="1" fragment="single">MFQPPVHTMPVYINAENIKNEKIKAVHNLENSAGNILISDVRLPPPPTFHNTTYQPPSSSCQTSPVCLGDTIPSSSGTDATAFEPANSMANLNTDAILEVNRLMVLHSILDSVTVVEQEWPRSAILAVQKRFERMPRNGWPATLRYYIQKVGCTLDIDAFKKFAQNEAEREIRQEENGERRRIATCLTEPCTLTNTTEYINLRDKFLSTIKEISDKEIGKVVVRTRKLPSELVDSNVLDLINRIIGEYADSCVPMTITAVARIIQAAQPRSAWKENIESKISKLVLSKDLLEKAREHEQLSTSEMKSLKKIMREFNLNLSSVTDLSEALVKKKESLNVCEKKITMYKSGKQFRKENRRFYRGLSKRVESEHGVSRDLTVILCLEGTPQADWFYCGLTYLILKGIPRRGSDYRPITCMSNLYKLTTKMLAENQLGSVRGVQGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIERGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNPLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLEIIEDSRGIPTSKLFEEVQTKLLARVERLCHTRLNARNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRGVVLSFEYMLLQLLDCLEKSKEISTGRAAILKLENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLTKLYNEIEKRKLHSKLYNAKKNRLVSVSDSSRWLKIGNIRPRDEAVFCYIQDRNVFWGADGMCQHCGKSVKILDHLATRCEKMLGQDYTRRHNEVVRCTHLLLLKRYKFKSSKRIRSHSYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQTLETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVIKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY79</accession>
    <name>A0A4V2JY79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit Rpc8 of DNA-directed RNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0246p0010</name>
        <name evidence="6" type="ORF">CWI37_0969p0020</name>
        <name evidence="8" type="ORF">CWI38_0134p0080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000969">
        <property type="protein sequence ID" value="TBU00557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000246">
        <property type="protein sequence ID" value="TBU03711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY79"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0246p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0969p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0080"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="5">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU03711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="176" mass="21048" checksum="AF6FDFC09185E76A" modified="2019-07-31" version="1">MFIIAQIEDVVKLTLDDLDLNIKIIQELNIKYTNNVINNIGLAISIEKLRKIYHYKIVDGYLHASVKFDVIFFKFFENETIYAKIYKQEENGIWLALPFFMNIFVKEENLPKDSSKTFTNSKNNRKNVLWYWMYKDSKLYFKNNETVRFKVTKIEFSPFLVYGRMNDPGLGPISWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE2</accession>
    <name>A0A4V2JYE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0015p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="47231" checksum="844AF823AE613A8E" modified="2019-07-31" version="1" fragment="single">MQNLYKEIKINILKKDYSYALQQCDIGLSISEEDELYFLKAYILAERSDDLNDIEESIELYKKLPLQEKYLQGIVKSLNKKFLLTSEKVEEENLVYYKFLCDKYFENNKIEKYQELIKKTLEQLSEGEKYVEFLCDIKIEKERYFGEYFIKIKEIYTKFCYEIYKKRVLFSEKEIKNKIRLEKERIKIDLVAENINQEIFYFDILKLHIADIYLEFDKTKKEKIDNFIKSGNKNVSIENIINLYRMDFGENRSFQPFFIDLNTEYLIEQSLFSMCLKINYTIQQKDLKNISVIQPIIKYYESVDCLKFKTSRIYDFLVKLYFDYKMFDEINDVKNKVSFEDLETLYMIIFALNECVDFENSLEYIFQNNIDEMIIFNLENNYLDCNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP0</accession>
    <name>A0A4V6MVP0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleotide-sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0259p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000259">
        <property type="protein sequence ID" value="TBU18001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP0"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0259p0020"/>
    <dbReference type="OrthoDB" id="2191964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38080" checksum="5E004F383E35E25A" modified="2019-07-31" version="1">MFLVFLTDSLTIIMNASIMKAERNKYLQILQKYIAIVPIFIQATINGYVIRKFTGRKSSSKCLPILMVELFKLIISSYMKTKQPVDYNLDIFTMGIITFCKSILMWNFVYRLHPMYFSVCYQSRIIFLCVISYIVMKKRFFIYQYWGQGLIFIGIILPEILKNHIKSKSQNVEVITCLAIITAGFLNSFGSVFFEVKIKKKVQNFWDYTFQYSVFAVIITFIGCLVEFYVKEIDIISNFESLFFWLAIILNSLGSMVASYLALILCPLTRTFLMILSSAMSTTVISLLLQNKIQPINIFSLIIVYTGTMIYEIGNTKTVNNKKNNHDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXT7</accession>
    <name>A0A4Q9KXT7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1220p0010</name>
        <name evidence="13" type="ORF">CWI38_2637p0020</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001220">
        <property type="protein sequence ID" value="TBT99776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002637">
        <property type="protein sequence ID" value="TBU06132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXT7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1220p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2637p0020"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT99776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU06132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="105" mass="12527" checksum="C97BFFAE81A58CA9" modified="2019-07-31" version="1">MLFCPDCENILTTERIQERLSLICMTCDYRYNIEKPFFKKTNYKTKVIDDVYDENESFKNAATCEKKCNKCDSNSAYFIEMQTRSADEPMTIFYTCVKCKETWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYA6</accession>
    <name>A0A4Q9KYA6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_1149p0010</name>
        <name evidence="11" type="ORF">CWI38_0564p0020</name>
        <name evidence="10" type="ORF">CWI38_1848p0020</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001149">
        <property type="protein sequence ID" value="TBT99987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001848">
        <property type="protein sequence ID" value="TBU10325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000564">
        <property type="protein sequence ID" value="TBU12991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYA6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KYA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1149p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0564p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1848p0020"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT99987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="202" mass="24044" checksum="AE00A0B7BE9B34D1" modified="2019-07-31" version="1">MNKRTTQEEKRQKVLDFFKEKKEFFTLKELEKLLPKAKGVVSQKVKEIIQSLVDDDLIKQEKIGISHYFWCFPSDTLHTLELSLSKCENENKKMKEEISQKEKELKKMCKLRQESDIRSDMIVQWNSLKDTVLQQNKEINMFSECDPDLYNKNLNEISLMKESINKITDNIFTLQSYVSDKFNVERVDFNNNFSVDDDMDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L195</accession>
    <name>A0A4Q9L195_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0970p0010</name>
        <name evidence="5" type="ORF">CWI38_0940p0040</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000970">
        <property type="protein sequence ID" value="TBU00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000940">
        <property type="protein sequence ID" value="TBU12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L195"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L195"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0970p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0940p0040"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="63" mass="7321" checksum="ACFA32EF83471008" modified="2019-07-31" version="1">MVDIKIKENEPSGYMSHNKPFGPGSRRCRACHTHKGIIRTYGLNLCRRCFPEYANDIGFKKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE50</accession>
    <name>A0A4Q9LE50_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2610p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002610">
        <property type="protein sequence ID" value="TBU06253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2610p0020"/>
    <dbReference type="OrthoDB" id="2201422at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25509" checksum="F0385503541C1321" modified="2019-07-31" version="1" fragment="single">MKYGIKTIKPSNSVICATRTTFKNIECVAVSKGKRIDLYNYELKQIGTIYTHTIITHMTSLKIKEDFILLCFSNRNNFSLFVNGNFLMTRFLISSWRDLGFTNDHSEGNELNEIDESTYEYSIGFSIPVKVRSSSSIIVVVLKNNQVLVAYPSVKSISFDTPVISQLSLQIIDFVLLSSKILFLTKDHENKFFLQEYSTVNLNVQLESSKDLGKEFLGIIPVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEE9</accession>
    <name>A0A4Q9LEE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2607p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002607">
        <property type="protein sequence ID" value="TBU06274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2607p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19176" checksum="3D20970AA3EA2BC0" modified="2019-07-31" version="1" fragment="single">KTDVKIRNNRPEYLFSKKKNKLTHIELALIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGTNTPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEAETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ57</accession>
    <name>A0A4Q9LJ57_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2296p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002296">
        <property type="protein sequence ID" value="TBU08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2296p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34434" checksum="E9CAE8A0A0ADF7B9" modified="2019-07-31" version="1" fragment="single">MTNEITKFINNIGLEKNKTNSAPNVQCGGDTATLLERIGVYKHLGIIENSRSVSTSKKFKCVQIKLIAQVQRLCRTRLTTRNLFQAIYQHAISLLNYHKGLDNAVRVVLVKNKKHIRLRYKERLCLPHKELEEKNMLLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEVTKKKSEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPLDEAVFCYIQDRNVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJI0</accession>
    <name>A0A4Q9LJI0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2271p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002271">
        <property type="protein sequence ID" value="TBU08369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJI0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2271p0010"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="455"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU08369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="604" mass="70159" checksum="F500960C5F71D46E" modified="2019-07-31" version="1" fragment="single">SISHLNRILSLTKCKNCFKYKITKMKIQCRHLLCSECDTLSCKICSKHSIGIDIHVYTFLHDLLSRNCNELNEFKIYRKKEDIWVESQEVFEENICVKNNLYKYKYESEKEGKQEFSDLKGEILNLKNMFFGEEKNAVENRKNNENETISTLAESSFAIPFTSPVSTQKSNNESKFTQFVSSDISKEKEIKNKENLCVTGFDKNMNLRDKERTLRLIKESKYDITGKKISNKNNENIDKISTNFTEILNKNNENIDKVGTNCTEIIEKEKQNPNKNNQIVDKMNKNGREIIEKNEKQISKNRFDSIKINKNETNPIITTVDHPNSESKILKNIKNSIEDKNIDSHKKTKHEISPKKSSKNPIISLTTKSWKNKITKNENSTENQNNFLPNLKSEPPKNIKISLQNSPNQVIQPEIQNQTNLDAFVFLTSGLSSEENIFISKTFWSLQNKLNIPIEIKSEYSSSITHLIVNIDKNGCCLRTLKYLLCILNGVKVVSYSWYKKLIKVPSVEEKDYFIKGDNISGGNNVPYQIYKNAQNGIFYFNKINFLIQKKFITKDLRKVIKNGKGKINENNFEFTNLKVQNEKEIYNFISNGTFLNYKSDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLA3</accession>
    <name>A0A4Q9LLA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2184p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002184">
        <property type="protein sequence ID" value="TBU09099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2184p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="7902" checksum="F804F55C5046448E" modified="2019-07-31" version="1">MSNLYKITKKSIKESFNIKAKADNILEAPRYMYVAEELGSYEYSLSSVQIKNQDNMDFTKCAIILTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM63</accession>
    <name>A0A4Q9LM63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2197p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002197">
        <property type="protein sequence ID" value="TBU08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2197p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8180" checksum="5AED8EC36A23874A" modified="2019-07-31" version="1">MNKNSILFLFSKIITIFMILKNFMNLNEMEGMVDVKGVGVTDVKLAEVVAVDVLEAEVVNVTAAVVDAVAAKFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNT1</accession>
    <name>A0A4Q9LNT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2176p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002176">
        <property type="protein sequence ID" value="TBU09175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2176p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="10130" checksum="A1488DC3983F69EE" modified="2019-07-31" version="1" fragment="single">MGVCVGGGMCRWDGGLQIRTRFCISGRVVCHGKLVSMPFTGKFCVVGGVGGCGGEETVYVSRERGEWFVGSSVIGGEGCGIGEYISCSFRIYFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNY4</accession>
    <name>A0A4Q9LNY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex exonuclease Rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2002p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002002">
        <property type="protein sequence ID" value="TBU10128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNY4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2002p0010"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="55"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25073" checksum="B1443120D9F14CCE" modified="2019-07-31" version="1" fragment="single">KFLPGEKMPTIEGYINGHGSYQENDGLYSSLYGNLVVIDKLMTVQPVIDFRYNPEVGDVIIGRITMIGNKKWKVEMNSKAESTLQLSAINLPGSVQRRKMFSDEMKMREYFDINDILVAEVQKINKSGNISLHTRNEKYKKLTNGLVLEVPAMLVTRYKTQFLKIESIEIIIGVNGFIWIGSDDLNYENMKKILIIANFIKNIANQNKVITDTELLKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP47</accession>
    <name>A0A4Q9LP47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2164p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002164">
        <property type="protein sequence ID" value="TBU09281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2164p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="291" mass="34317" checksum="08BAF0003D3C0E8D" modified="2019-07-31" version="1" fragment="single">RLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLSHDYTRRHNEVVRCLYLLPLNRYKFKFSKRIRSHSVQEILDNEYAEIRVDTRIKNEITLIEVGITCQDSLQIITLYEMTWNSIVNKYYKSHLKRLEIPMNVEAYIQSIVLKKTVETIFFDRRRGLESGLNAEESWERASMGVIMRSEMQQRIIHLFISEEVTTFEEPTININEDSDLEEETSMVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP83</accession>
    <name>A0A4Q9LP83_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2161p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002161">
        <property type="protein sequence ID" value="TBU09321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2161p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="559" mass="65414" checksum="5026722EB7BDF4EC" modified="2019-07-31" version="1" fragment="single">VTYNDYLIPFVSDNPPTTFPSLNEFVSIINQLLNWKAAGIDDIHNFFIKKLTTLHKYLYDIVKVICLEGTPQADWSHCEHVCYDMKASNLYINHWMERLEVSKAFLEFYSPLSVSVLFIFRQKVCERKIVSGTPITWRRYDVSLDYVLSAKEQALLNIAPNKEYGNNLNATWINVKEDYDSIDYAYLTQCIENLNIPDWFLKFIKPEKLMQKNIKKGVLQEDSLSRLLFVLSDEKYTKGTVQTDSESQSTNQILFFDDLKLLAKDSSTLSAMTGEAKEFLKVIGLEINKAKSATKDTCCVSVFKYLGIIEDNRGIPTLQILCQPVLRLKPAEFSELDDLVRAEFLRSEYKLVAAIHKVENNNKNHLALSKGFLKVKYMLVEEITKKSFEDAQLAKLYNEIEKRKLHSKLYNVRKNELVSLMFCYIQYGDCGMFGKTVYHLATRCKKMLGYDYTRRYNGVFRDLRNNFFDRRRGLGNRHPLLRAAENEEDDVKEFKTKNIPPYFKSRNHIRVTNIKYKRRFGVGRRNNYGKIGRRKYMKMIKKSYNTEFINKMEKGELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP88</accession>
    <name>A0A4Q9LP88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1926p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001926">
        <property type="protein sequence ID" value="TBU10229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1926p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="29417" checksum="81227461A7345728" modified="2019-07-31" version="1" fragment="single">KDYPHRPSSPIKENFRKESTRNGESKDYPHRPSSPIKENFKKESTRNVELKDYPPHGPSSPIKENFKKEESMRNVEIKDYPPHRLSSPTRETIKEESTKIVAPKNYSTHRPSSPIRETFKKENIKILESKSSENSTHRPSSPIKEKENPQINSDSKSSDKSISSISTEKEEITVKDKISESMVPTKKISYGKPISRTFKNFKTFIEAVTSKFTYSFKPPTSWGCGEHYTEYKENKSESAVRPSIIGYGYSNYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPF0</accession>
    <name>A0A4Q9LPF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1867p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001867">
        <property type="protein sequence ID" value="TBU10299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1867p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="21609" checksum="77E1B984A316B13C" modified="2019-07-31" version="1" fragment="single">MQIHRLPFKSQKISNLTEYHLSNPTFKRSKQIHESLVFSFYKKICISTDLCGFKFLSKCSVVSKGGGVIGSVYVPFYDSKYSILKGVENVSKDMNKLKDMDIVEGKLEGVSDKGRVEGVNNTDNVEGVNNTDNDQGRVEDINKGVSDKGSMVGVNNTDSDQGRVEDINKGVSDKGSMVGVNNTDSDQGRVEDINKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU6</accession>
    <name>A0A4Q9LPU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1739p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001739">
        <property type="protein sequence ID" value="TBU10469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1739p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12916" checksum="2E0D90370C9F8A50" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWGRASMGVIMRSEMHEEPTPPLKEAKREEEGVKILKPKNNTPFISQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQD6</accession>
    <name>A0A4Q9LQD6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1893p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001893">
        <property type="protein sequence ID" value="TBU10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQD6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1893p0010"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM OB" evidence="11">
        <location>
            <begin position="98"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="34480" checksum="F3A8374A6CE2282C" modified="2019-07-31" version="1" fragment="single">MTDPSEELQSLFYNFLTTEPYKTKIKSILLHNLPLDIHTVPVSLTDIQFYSSDLYSLIVQTFSATSTLLISTFNTIFNNSTDIKLIPLFVNNPFIHRMRHLRSILLSKLTSFSGTVTRVSQVRPELSVGCFVCKACNATIQDVQQYSYYTLPSTCPNHLCTNRKAFSLETSKCIFLNWQKVTVQEDTHQTPPGTLPRNIEVILRNHLIESVKPGDKATFTGTLTVVPEQPGFIHTTLQPTLSGITDNEKKNKNIKEINYRLSFVGESVEIQNEQKNNFMNSDENKKNESIFNEENFSNSILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQD9</accession>
    <name>A0A4Q9LQD9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1574p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001574">
        <property type="protein sequence ID" value="TBU10743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1574p0010"/>
    <dbReference type="OrthoDB" id="2189624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="37355" checksum="DCD0D652F929371D" modified="2019-07-31" version="1">MNKLQPTIKILETTYFSSDISKNDKFVVFTDSYQNISILNTQTLQYHKIVTDTPTITSYSNTYVKYYPSGNTLCSTTDTHNGLRLYDISTSKNIFNYKKDTLFTHCYSINNTLAAITPSGIKFYDLKYRYSNMFIPIKEVTCIEWKGLYLYVGTDSGIYKYDVRNQQAIEKIDLNENNIREFDISNIKIKNSNISSNINTEMKVTDILSSSSYDFCTLKINNKNYIKLLNTSIIKECISKKMYKIQDIQFIIAMYCNSLLKLYSYTSELEIKFKDIKSIKGIEYCRSRNVLYIFTDTEIYYYEIDKYIDMKRLAYRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL4</accession>
    <name>A0A4Q9LQL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1565p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001565">
        <property type="protein sequence ID" value="TBU10758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1565p0030"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="46722" checksum="AC75ABBBB644052A" modified="2019-07-31" version="1">MKFIFIYIMVVLSTLKNKKECDSKQYLNKVSQKDKIMKNVVMNNAFRMRKESNDLKEIKEQMKVRESYCFSLKECEDKLKRNKNLLKRKNLLIVNLTTESEIKNNSGNSGSICSIGNIGHSGHSGISGSIGNSGNSVNIVKSDKLKEQKKLNEEISKLKKEKTEFLLKKSEILYSKICATRKIIELSLYFIKNDKFLCKFGDKDISFIKTLRGRYEEFRKECDCDNEVLQTSVQELETLIQNKSILRDEIKKETDFDNKSKLNNKSMNDTSGVVVETNKLDDLVEFDGELDTDLLSNEKIPISPGKFLSSTLRSEESDLEFQSAKENLVGLKPQSIHQSISNEHLNTSLCNPCTSINTENNLRNFKDKSVSTTNLCQNKTVFDNSFRFGGSTEYCFEIKLRKREKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQW8</accession>
    <name>A0A4Q9LQW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1556p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001556">
        <property type="protein sequence ID" value="TBU10774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1556p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12258" checksum="00B4801653E3BEA4" modified="2019-07-31" version="1">MFIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR10</accession>
    <name>A0A4Q9LR10_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1470p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001470">
        <property type="protein sequence ID" value="TBU10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR10"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1470p0010"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020285618" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="420" mass="49846" checksum="9952FA47373ECCE9" modified="2019-07-31" version="1">MIIFLLSFIEFISLSPEYNPMSVFETDFPKTLEITRGNEVKVYIITDNYESYGRSFYRRLGYDKHTNEAVIISKESYIEDSESKTVKTVKNLDHENIEKLYYSTKINGVEYCVFEYIPETLESYCIKNEIKLDGFIFFVKQILDAIYYLYSNRIAYKFFSMHHIRITSDLKIKLVDVLASEFNTSGCSHDFSNDCNVSEYYEIYCAPEYYLKNPCKCKVSIWCLGILLRENIIYIPKIDDLEKHVRLYNCWYDFESILLNFSPIDRPWPLRALLHPIFDNLFNFLFCFESIENFIYNIEGVFITKNDKTINYKKENINFSIFCCCVDQKLVKSCIIVSPPDEHYDFCDLCQRFPTSRKIKFKIEINEKIIPVQLVSYNIYYELKNLFKILLTEFKHIKRVNCNPKVLVSKIPRLLSSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR25</accession>
    <name>A0A4Q9LR25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2048p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002048">
        <property type="protein sequence ID" value="TBU10071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2048p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19698" checksum="4A252848BFBC8EF8" modified="2019-07-31" version="1" fragment="single">QDSLQIVETEKLRKYDLLANELGLIYKCNVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIKVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR51</accession>
    <name>A0A4Q9LR51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1438p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001438">
        <property type="protein sequence ID" value="TBU10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1438p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="33606" checksum="9FFD720674E5E06D" modified="2019-07-31" version="1">MYNNYFNDLCYISIEDISNGIPKNIPEKYQKLDSWLGRNIYVVFYVKIFTEIKIFDKNIDKSRMIELFNGAFGMKAYYLYGSYNLYIIDTIKSNLYDKNTSIQKTTKKTIMNQYVLSFDMEYPPNLYFGLKFLYPERSFGFYSYSHSTEFYYFYLDKYREENEYKFKILFKHSYISFEFNFNWYNSEQEIKKIGTSKTFYLRVMTGKSYDMIEILRSMDQKYFIIKDVSSSNYELRKLYFFDENRNIQHQDKTYNLKELFDYLVFEKHIYICMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR86</accession>
    <name>A0A4Q9LR86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1432p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001432">
        <property type="protein sequence ID" value="TBU11008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1432p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127784" checksum="126A83ACE1972324" modified="2019-07-31" version="1" fragment="single">MNIKLHPTLTFTLKNKYKITQTLTSISTVTTTPLITIPTTVYNTPTHIHISPSLPSYPYIHTLSLCITNLTFTFSYNCIILSKPFTSTHKTVFLIEPYTLRNMKRRECNNNKDSKEDSKDNNIDDENINNGTFTNCNCGTNNYSNYSTNNNNNHSTNNYSNHSTNNYSNHSTNNYSNYSTNNNSNCSTTNNSNCSNDNCNNNTTNNSNSNTIDNTINNTNNNTNNTNNNTNNSNNNTINNTNNNTIDNTINNTIDNTIDNTINNTINNTINNTINNTSSSTYPNLFFDIPINYSSHTIYPFIFFYSNTDLIISYYNNNRVLLYSHINNSSKVIIYNKGVCSVSVEGVIRLYLVRGYLYVIRVPVIPMEVFMYFSDLLMFVDNTMYVYRGVIKTSKEEGNIVEGVSKESNSKESNSIGGNSIEGNIKEGNSIESNSKEGNSIEGNIKESNSKESNSKESNSIGGVIPNNPNTLGFTVDNHKDILIFKNIFMSNPSKVNIAQVGKLILLSVPEDSTIYMLDNTYTLVEPIDEINSICVRMNEEYEYCVVNSVLCDNKRIYLYDNDNVVCVWEYRGDNNTSDNTIESKGNNTESEEDNISDNNSVIHNIKAPNYNTSNTTDNVNNVTDNTTDIRVYGKGVILCKELLDLGFTVNNSSLVFNKDIIRCSVIPLINATEEDVCGVTPLDEEGYGLKGVRNMDILEGLNDSDSEQKGVSNNTNEQQGLNNSTNEQQGLNNSTNDYNPLNNSTNEQQAVSNTTHNYNPLNNSTNEQQGLNNSTNDYNPLNNSSNKQHPFNNTTNNTANNTTNNTINNTTNIKDEVDEEIRRIKESIMNIKIDKKNIRTYSYFVEEQMGRVDTVLQRMYKKMVKCEKIQENGGYFNKLVGILRHKIISYTFLSIKSVRNSVEYFENKIFGRSCCVYEEGIIYGRENRGVVYEEGVSFKTDGVSDNVVVDIEERLKGVSIGEDIGSIGGVNTKGEYRGVNTNGNDNKGVNTKGEYRGVNTNGNDNKGVNTNGNDYKGVNTKGEYRGVNTGNDNKGVNTNGNDYKGVNNNTILEDKLKGFNITDTEDNYKGVSSVLPTSSLKGVNTNTSLPTITPFNQLQSTNTQEGVNTNTSLPTITPFNQLQSTNTQEGVNTNTATPTVTPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA9</accession>
    <name>A0A4Q9LRA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1467p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001467">
        <property type="protein sequence ID" value="TBU10934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1467p0020"/>
    <dbReference type="OrthoDB" id="2189453at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="28259" checksum="0EA6FE441BCA92D2" modified="2019-07-31" version="1">MNKGVFQTIKDSNNDISNPITYSNSNNKPTENICDIIEDIKKYKEIEIFGNIFRKQIQTLGKLNSKNFTRLKCMINTDEMFVLISFLKDMTKSECIVVGRAYMKTKVNDIDKNILFHIFRGFLNINEPSDTYKTIFNDFQILNILKCGDSDNLNDLSANELSEYSNNTTIILTSLLCKRKKICVGKYLTVYLSKIIRQNITVSHLRLLLVVSRNYKECFSTEITDFCRNYKHPIINEILKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC3</accession>
    <name>A0A4Q9LRC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1533p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001533">
        <property type="protein sequence ID" value="TBU10817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1533p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="555" mass="65811" checksum="423806559C3A2DA5" modified="2019-07-31" version="1">MFFYILFSVAAFPPDNDFTNLSEDPITGDHIRLEMPYNLQAKNTEIENFIYLFFSLGTKENMDGLIRIASFYSSELKKYTIKEIHPFLTHFTTFICSIVYLKKNYGGFEKFRPDFLFNLISFGKFIEMYKTNEATKMAITDLFGNSLDNYIDLKSVEIRDWGSPPINHMYNAIKDMFRHFFPGLHQKNAHVKHFVYMLNFRKLQYSLSRGTFEFFLCFFYSLVRFKAFEGEYTENCSVKYMLPSRKTVEKIKEDVAKLSRLTHNNNNNPEYKNILEYIFKPFSKNILKKETGFFELFDHSENFSLNNKLEDSKFSQDFVEVFCNEEELNKIKCLNKFIKEKTKEEYHDYISAVICLEAFNLKRNFSEGNDITRIIMDILFLTDVLKTKFEEIKAAENRRQFRKIFFEALIKELGKRGIKLSPDTEFDFLNVIKLPRTSSLLEMYYFAELFYGNIARRNFSCSLQEKLNQKLNTKEKDSDFTKTNYLLYVFNNEISGLTQEELKNLFSAQTPETPVSKTTNSKNFGFDKIFFYIVLPILCFCLIIIGAYWYIYMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC8</accession>
    <name>A0A4Q9LRC8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1365p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001365">
        <property type="protein sequence ID" value="TBU11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1365p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24319" checksum="AA046C86D9482435" modified="2019-07-31" version="1" fragment="single">LLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNTVETIYFDRRRGLESGLNAEESWERASSNVIMRSEMHEEPIPPLKEEKREDDEEPTNNINEDLNLEEETAMVKEVEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD8</accession>
    <name>A0A4Q9LRD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1452p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001452">
        <property type="protein sequence ID" value="TBU10974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1452p0020"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="299" mass="35433" checksum="B649696A8273F125" modified="2019-07-31" version="1">MTEEVNEQYTIRNKQREIGYKKPVTKENSRGIPRSMSFEELDYAVHALLDVNNVYTFPVKNYEEVYIKSLKEAQLAKLYNEIDKQNFIQRNIRPRNEAVFCYIQDRNVSWGAEGMCQHCKQSRKTVNHLATRYKKMLGHDYTRRHDEVIRFMHLLLLNKYKSHSVQEIFDNQIAEIRIDTRIKTGVKFRKKRLVVFVIDISKKRITLLELRKDDLLANELGLVYKFGTFETILVNRRRGFESELNAEESLERASLNVMLEAESRNNQYFFNASIKCGIMKEPTINIKGKLGFRRRNDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG3</accession>
    <name>A0A4Q9LRG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1434p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001434">
        <property type="protein sequence ID" value="TBU11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1434p0030"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="528" mass="60982" checksum="3CE7103178983C9B" modified="2019-07-31" version="1">MNQNRCLILYGITADSLTSALQMIEDVSKGKVIFKETCSIFENGVLMTYLCDNIDMAGICKILCSKGIKIMEYEKYDRFKDFSKNKYEDLIAISENELFKWQRDLKNEMFVIRNNEKIVLYENCRGENIKIIFECEAWQVKFSEDGKFMVVNKGNSILLLGGESYGIFCEIPVKGVLLGFGCQGRFCVIRDAEFVYFYDVTVMKELYRFEHEGSEVIWTEDMRYLKFLNFQETFSIKDCNIMQIDNICGINCEIIEKVSFKNDMTAIITNEKIKNVIFCVQDNIVSKKNYVNFENSNIFWSENGVFVEIVRKLDNKTVVSLEIFKKDGTVLIVPLDCSISDLIAGDNSFFIFDTEKKLKFYQKKISTFTLLSSVSLSNKVILSKSSAADIFAIYDYASDSVEFYEDGKVISTAAHTSCTQIKWSHSGIYCSTISSGAQLGGLVQVFDIDGKLIWKKVFNRLQDFHWRPFIQFTDKEYLECNFEKLTSEIKNLNDEIQEESENIPKKQLISEWVGFLQRKKALFLNLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH9</accession>
    <name>A0A4Q9LRH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1919p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001919">
        <property type="protein sequence ID" value="TBU10241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1919p0010"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="26711" checksum="FB4B3D355A39EF90" modified="2019-07-31" version="1" fragment="single">MPINICFILELEEKILIIKIYKKNKLKLIMMKGEESKQNKILVIHCGGTFGMVSSENGFTVKKNNVYEIFKKNFESEKSNFKKNIFDGEIREKNKSYVLYKKTFLLKNSYLEIEFKLCELNKIIDSSNVDISDWSMLCNIIDTCRYDGYVVIYGTDTMSYAMAAVSFAIKNTKSPIIFTGAQLPVVIDLKGMDNLIGAIEICGLMLEREMKCNVWLYFSGFLHSGVKARKITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS85</accession>
    <name>A0A4Q9LS85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1681p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001681">
        <property type="protein sequence ID" value="TBU10561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1681p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="285" mass="32809" checksum="6D4EA32397CED4E6" modified="2019-07-31" version="1">MGVLRPEPADFSKLDDAVRVALVNNKIYLRQRCKERLYLLITELGRGLHSVELQSEHILLQLLDGLENSKEISTKLATILKGFLKVKYRLIEEVTKKSLEEVQFAKLYNEIEKQKLHSKLYNARKNELVSVRNIRPRNEAVFCYIQDRNVFWGVDSVCRHCGKSGKTVDQIATAQKCQVMTIQSGIMKSHSMQKILHNKYADIRLIYKISIEIIPYAIPTNCIYLRILNGFPLSAKELESYQNQKRAANAPFKLSDDRGRGGSTLEELTININQKENIQRCENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS95</accession>
    <name>A0A4Q9LS95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1227p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001227">
        <property type="protein sequence ID" value="TBU11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1227p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020221653" evidence="1">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13122" checksum="46294C7EC04B5573" modified="2019-07-31" version="1">MFLIFFVCIFTSPNIFTESKNESVQHVEGAQNLPENSYLNPRRYRKLKCSCANFLAEEKIKIENSKAKRKIDFGSQSSEYTNNLQDILRKRLNESNNLEEDSKNKKILKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE2</accession>
    <name>A0A4Q9LSE2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1638p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="PITK01001638">
        <property type="protein sequence ID" value="TBU10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1638p0020"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="113" mass="12692" checksum="95450C51F7CDB440" modified="2019-07-31" version="1">MTYTIKKIHHDAKVPHRQTSGSAGYDLYTCTSGKIAPETTTFIHTGILLEVPYLTLILPRSGLASKHLIDVSGEYIPPNKLQEIVVCVTNYGKEEFIYNVNDRIAQMVFTFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ3</accession>
    <name>A0A4Q9LSJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1604p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001604">
        <property type="protein sequence ID" value="TBU10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1604p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="325"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="924" mass="106542" checksum="2CD29042DA46C3D4" modified="2019-07-31" version="1" fragment="single">MGRIKKVTSENIKSEKIKALNTLKNSAGEIKTCDIEVEMIFERLIPQQTFHNTNNQAIVARLVQSAWFSPYPRFLVPMPLRVDQPTALKNPNIDAILKGNRLIVLHKILDSVAAVEQEWLRSVILAPANLRYYNEKFSRTIDLDVFKKLTQNEAERKTRQEENGERRRIASCLTKPCTLTDTTVYISLRDKFLSKIKEISEKEIGKEVVRTRKHPNKLFDSKYTDSYLPMTITAVCYDEATREEKPRSASKENIETEKALTSETKSLKKIMREFNLNLSSVTDLFEALMEEIPKRGSYGYLTVLNEHVVSRDEIVSFWSIMWNKDDGSGTPQADWFYCGLTYLIPKGIPQRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGWLSENQLGAVRGVQGAKEQALLNIAINKEYGNNLKTTWIDVKKAYDSIDHAYLTQCIENLNLPDWIKIERGDLQGDSLSPLLFVLLTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLSFAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLLILDCLEKSKEISTRRAAILKVVNNNKTHLGLIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSNVSDSSRWLKRGNIRPRNKAVFCYIQDRNVFWRTDGMYHLATRCEKMLGHDCTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDKEYAEIRVDTRIKTDVKIRNNRPEIFILDKKKNKITLIEVGITSQDSLQIVESEKLRKYDLLANELGLIYKCSVEIIPYVMTWDRIVTKYHKSHFKRLEIPMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP6</accession>
    <name>A0A4Q9LSP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1133p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001133">
        <property type="protein sequence ID" value="TBU11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1133p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="31263" checksum="8C64D812E166FAE0" modified="2019-07-31" version="1" fragment="single">MKPSNNNTQKNTSSLEKIINHITSTTTIKNHILESIITSHTKKAIIYLPDPSDLLTTIKTISIIPNTGNILVLIDDTHFNERFNQYKIKFPHILAPSEKLLTYLPHKIFPLSYTNILCVQNNSKFHELQENHPKIISTLVLDDIKNIRNFLGLVRKLSNSLLNIQNIICLTTSPFLFIDYFHTKDHLFQCITPILYDKPTSFFYKKLLELSEIIYYKPCKEISSSNNTENNNNKLDNTTNTNNINTDSKLDNNSINTNNINTNINTNINTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV4</accession>
    <name>A0A4Q9LSV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1318p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001318">
        <property type="protein sequence ID" value="TBU11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1318p0010"/>
    <dbReference type="OrthoDB" id="2194902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="37976" checksum="D5DD0CD3EC66EFD7" modified="2019-07-31" version="1">MFVLTNYNEKEPLEIKSKNPLILHKKVENITYQSTEVESKLNFYICDSKDTLENFIPVTLHRINIITDENFKKEDYISNCCNIDKNAKIKNEVPKNSYSKTVSVLNQPSKYIQPVLPPKNENFKFYDLENLFPKEIIQQFSDLNTHLSHLEPIYLQLYHKELIKIKNADKKNQECIEKIKKPKIEKFECIFTPETLKVHILILDCLHKLLTMEYHRKDLIIKNFPKKFNFFISYIQEFISNNRLIGLNKDKFCVIYYILFLKVNNFVSNLKEMPFYDNKEKKVIEMLRIIGCIVKNNEVKMCREPIYEVTRRDRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT79</accession>
    <name>A0A4Q9LT79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1039p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001039">
        <property type="protein sequence ID" value="TBU11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1039p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="597" mass="71055" checksum="84EB21EF081E1B85" modified="2019-07-31" version="1">MKIAKIMEEDRRSVKDINGYKNNEKYNLTSFNCDNNRIDMSRTYYSSIREKYKHIYKIILLVVILVFVSIFTSIYIISLWHINKDIEKFSSNIENAKKDSVFLYLRSNLSNILQKKILFIELNKDIKLKRNIFYRDTVSSNKEILNKDILKCSNFLYLNLSILKEKIELSFFSKIGFYFKKKNSFTLFINLTEHIIKRFKDTQNESKKETITDKNTGKTKKFGKENKEKNTNRNEGNANIKTRSDVSNEENPETNGMNKTFSEQLYIDIINQKIIYLSFLSINDSNNRRHQDKCVLSDYDCKYSIVDILAYIEYISSCNTEIYDKIKNSLRKYKSTDHYDNTNRHKNRLQYFIKDNKEGINKKSDLGNTSSEEETSEKETIDDNREMKEKIEEKNRSAKKNIDDNRAVKEKIEVKNRRAKKNIGDNRAVNEKRNMEDKKDTRNKRKIRVVTGMKYRQNIGNIKDRRNIKDKKKESNVKGTKDSRNIRSLKNKKIQRTMKNRRNRKNDRAYKKKNIKNTRNIIDIGSNNDKNVNDCNSNAYKNKYEKSDLQNMIENFNNENTYALYPETVANLKVLKEVREAFFQIHKKFKKIYSNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT98</accession>
    <name>A0A4Q9LT98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1018p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001018">
        <property type="protein sequence ID" value="TBU11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1018p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="796" mass="95323" checksum="EA0A69B06B054F49" modified="2019-07-31" version="1">MSFNFNIGSIMKPNSKRASRNLYFLLIYFSCWVYLTTVSFYVVNDENRIKNFSTINSTSRIAEIENKLTDWFIEEDKISLIENNILCFESGEETKYYNPTILRISYPNEMLLNPIFSKTSFESKQTNIKIFLKDVSYSALLLFLKLIDNSDIIVNQIKMQDFLDILMIISVLDIEKSKERNIFLKELLRNFMFAMENGNEFFNFEKYCESYHYKHIKKSILMDLLIFFIDFITFNDKSAQRYIVSAERKLRFKNITKYFTSSNSLEKSKINGINLRLDDTTIRKLYRIMKSRYLIITWSILLEATNLNLLYLIFWEEEIYIKLVGLFGITRLHLDKLYIYYYENPMNIFTKKQTDIFTKNLKVLKIEFDSTPDELKKLLSLCCNVQKLTLSTKKFDFERLDCLINFSLQNPNINCKIYCLKYEFIDTEIDLLKRIPNNLVCYVDYAKRQASDIEIPIENLPFLCQYYYQYPDAKESSILSKHFEIYETIRFKALGLYFVHDSSYITHRDTIFLFLKHFNTIKYFSLRNIVICNELLVYILELNTIVCFTISNFVCAFNLKCILKNNIINRRLRSFKIENSLGYIDSSLLIFMSRLECMQYVKFVGIFVKNLTSYLERIYRYIFGSEKQIESKIYIIRLEIIEAVLANKSNILNFLSKIIDFTNLVKIIYRVNMITETEYKFFGQMRNLETVYIVIRNMNEYIDFKKLFINRDLFNTVSSLSICVSKILKEDIEILRLFKKLFFLSLSCEEIYYETILNIKKEHFKNTQFRVNRPIRYERSYEVNNYLDSEFNLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM1</accession>
    <name>A0A4Q9LTM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proliferating cell nuclear antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1464p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001464">
        <property type="protein sequence ID" value="TBU10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1464p0030"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="14689" checksum="495EB0A65A00A2F2" modified="2019-07-31" version="1">MSDVQYEAEIEMPTSRFLLLPKIVGTFAEYIVFEADKDKISFSQSGEMTESCLTLKPHQFTESESNSFSVTSHVKKEVAMKYLNCCAKSASLCERVKISLGNRTPVFLDFSLGDLGYIRYYIAPKDDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN5</accession>
    <name>A0A4Q9LTN5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_2074p0010</name>
        <name evidence="15" type="ORF">CWI38_0395p0010</name>
        <name evidence="14" type="ORF">CWI38_1164p0030</name>
        <name evidence="13" type="ORF">CWI38_1681p0010</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002074">
        <property type="protein sequence ID" value="TBT97785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001681">
        <property type="protein sequence ID" value="TBU10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001164">
        <property type="protein sequence ID" value="TBU11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000395">
        <property type="protein sequence ID" value="TBU13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2074p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0395p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1164p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1681p0010"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT97785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="163" mass="17252" checksum="F132CED099A95FB0" modified="2019-07-31" version="1">MAESTTTDNSAIYFPLIRLAALLVGVLPSFIGVGKGMQEAAVGICTSASIRLDLSITIIPLAFISASLIYSVLIFFIFAKYKVEDYSNGFQLLTACFMTGIGGMVASIATGTIAKSATVTRAQQKNFTTQFLLLMIFAELIGLFGMILALAHGYEVISSGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU76</accession>
    <name>A0A4Q9LU76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1373p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001373">
        <property type="protein sequence ID" value="TBU11120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LU76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1373p0010"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="9">
        <location>
            <begin position="188"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1461" mass="167582" checksum="45BF715128978DF3" modified="2019-07-31" version="1">MEEHEKNTTRNRKRKEEEENKGNDKSNNNSNDKSITQDNSPNNISNNISNDMSNNISNNISNNLPHNLSHTISNSLEISDLKTKNLNSKEENKEEDPAFLYEQSKEEFKSALDFSTPTGIFTFIKIPAMFFFVGFFSYLIGKFNFSIFFLFFILYSSYFVINRHLKRFEKSMKALIFKQTRKQQTLYTKESVEWLNYSIEKIWKVLEPNISQQLFRTINPILVEKCPPFLSQLRLTHFTLGSQPPQILNIEKITTNVRPNTEESDFEDSDNEDSDNEDGIDNKGSDINKGSDINKNTNKEYNNNKGYDINKGSDINNKGSDINKGSDINNKGYDNNINNINNINNKEYKRNNKEYKRNNKRNNKEYKRNNKRNNNTNNTKSHDSLQDTIILDTNILFIPCEVSKDTLYYINKNPSFTWNSKIILVARLGKNISLDLPILVKEISFQGHARIIIKLQHEIPLIDSIEFLFMNSPHIDFDLKPLKAVDLMDIPLLSNWINLTIKNTLETLLVNPNSIKIDMKQLQIEKSYFIGIIKIRIHRFIGINSEGGVGIIGGKNSTSNKYDKNSTSNKYDKNSIINKFDKNTTNTNNNNNNTNNKITNNNTNINYDFSPLKIEPDKLSVNIGVDNKLLFTTNQKKYSRIENILNFNEYFYFLIQNTDDNLNFEIRIGFNKIGSGNLNVKKVIEMGRGVVSVKVKHKGILVGIVDTMVEFYRIGGGGGGGSGGGGGSGSGEGNKSRDGNNKSRDNTNNNKDKDNSNKDKDNNKNPNNNNNINKPDSAIVTLKVLHVEDMLGLNTSRRKIYSSFCSFIISDRKCCKSGDKKKGFFNPFSLVTGTASVLGNTLINAGNALGMGIGGEEVDLSVLSRATPYTFYSFETKHSVETNSPAFNQEFDFYARNLKNDFLFMRINELGTENVIGKVEIPLNEITDNEECWYKLKESESGRIKLQFKVKPIENTTIKYFNNNFDTFRDYKYFIKIEILNFSNLFLNGCYSLIVKNNFNIFYFNSFFIGKYKIEKNIFIPICDFREFKVFLYKEIDNSEEFIGEGTIELRGGGGSGDGGINDGTDNNNTNNNNSITNNNSITNNNSITNNTTDTNTNTNTITNNTNNNNSIINNINTTTNTTNTTNTTNNTTNTTNNTTNITAVSIEKSDVKITDLNISWIISPLYNYKGHSENPSKFKVIQVKFKEFYNIGCDFYCEFMSKNYILDRSVVSKNNILNGVYTLRVGSEEIRAIFRSADLGTNKILGECLIPKRVMNERVYLDEERFWVDCEIRVNVGELDVLEMKCGWIKICIKNINLKKLIDPLFSVSKNENKIFKSKVLERNLNIICNEEIVMWIDGWSDSVKIEVFEYKRIETNRVVGSCEIEMNFLSKQKRVIRWVYRGRYCCNDFRWDRIVEDIVRGRYCCNDFRWDRIVCSIGEGTVVMSIELEQVLNRVVCRGYIKRKDIVRGSVSRFIRLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU96</accession>
    <name>A0A4Q9LU96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1042p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001042">
        <property type="protein sequence ID" value="TBU11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1042p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13576" checksum="F6AD042DF7062BFA" modified="2019-07-31" version="1">MGTNPCCRKPEVRNYFLSSESLCNDNSEKESLNVNIVLSQEDKKEECACKQKSPSCCSEQKPIAPPAGNLCFHMNVIGDSAGKPEEEEPEEEPEEEDEAENPGSLKNLEINHMEQQYDKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA7</accession>
    <name>A0A4Q9LUA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0884p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000884">
        <property type="protein sequence ID" value="TBU12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0884p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020718674" evidence="1">
        <location>
            <begin position="27"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="344" mass="40676" checksum="77A32494BC70E001" modified="2019-07-31" version="1">MNLSYFFQTFLFQIFIYLKLECIATSRIPESNAYPGENTGHIKFSNYPKDLLSFAIHHIPNFEIFCKFLGEVLIDSHTSIIQKSLEKLQKAMFTCSKNLKHDEFQLGVMYYRACIDVFKDILYNMFKDVIGSKYTKPEEINEDISVFANKLNDRIFMNKLKEMKQWNSKKLTMKKNKYDIKKLIKDISEHEKISKFVFEQFFLFGSCLESEFIDSLNNCDEIKFSIILESEYLISVFIRDLIKKIGETNFLQMFSSENFSKNEQLALKRIYKQIESIEELEPFKSEISGSLTQYLNFLKKDVRVVFAFRKLDERLFSFIKNEILTSFVSKATNESICNKIFQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD4</accession>
    <name>A0A4Q9LUD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0826p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000826">
        <property type="protein sequence ID" value="TBU12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0826p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6763" checksum="DEF634BECDD1E292" modified="2019-07-31" version="1">MIFRCITKVKDSKFAKNIQMAEISKPTCEHIKMKAIIGKVYVNYKIYDTKYHLTDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG5</accession>
    <name>A0A4Q9LUG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0816p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000816">
        <property type="protein sequence ID" value="TBU12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0816p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="16542" checksum="F4F8BD0064418CAB" modified="2019-07-31" version="1">MFEVANSEIVKLRFMNKEVYTLNSEDTFENTLRKIFNEPVESYLTHDPTLFKDVEFNYDTTNGYKSEKIKKYLKSIDWKKETILLPYCFNIEYFKLFESLVNFRIILENFNGDFFLRFYFILDCFWFEFEYDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL9</accession>
    <name>A0A4Q9LUL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0791p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000791">
        <property type="protein sequence ID" value="TBU12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0791p0010"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="27501" checksum="BF738F0322BCE0DD" modified="2019-07-31" version="1">MNSKAEKYKNLATTCLSKKDYKGYKTNLKYVYDITQNEDDKIMLEKAVKMYQIYLDIQEFLKIDQKDYYAVLGLESKATHDEIRKAYKKLALKYHPNITKLQESNEVFGRIQMAYTTLKDEKTRRDYDFSRIYSRNTTYNGSERITPEHSFASGFHSTTQNPYGYPSFHSFSSTGFISPNEYDFYRAFYQMTNGPTFSTFHRPRRNNTQPIQQNDFKVIIFIIIIFLFLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP3</accession>
    <name>A0A4Q9LVP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0632p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000632">
        <property type="protein sequence ID" value="TBU12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0632p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10767" checksum="A7C074D6F5693F3B" modified="2019-07-31" version="1">MSVIEIPVKVYVYISSIQHNKTIKTISFDQQRELELNQNPKKLQRSTPSCVIEGAKIHKQQTHCYKIRKTKNGTRQMNTKHILPNYVTELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP7</accession>
    <name>A0A4Q9LVP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit 1 of eukaryotic peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0631p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000631">
        <property type="protein sequence ID" value="TBU12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0631p0010"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="2">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="270" mass="30840" checksum="8520A3244835C7A3" modified="2019-07-31" version="1">MCDSKFHVDDLLRQYEDESKFGIIVMDGHSTLFSTVQGNVKTILQELTVDLPKKHGRGGQSSVRFARLRLEKRLNYIKKVAEIMNGIYLTDSKINVEGLILAGHSDFKNELKTCDVLDHKIREKIVKIVDVNYGGENGLNQAIELSEDVLKELKLSKEKNILKRFFEEMALDGKYCYSIKDTIQCLESGCIETLIVWENLADKKDEEDFVDWISENYKEFGCELIFVTDKSAEGTQFVEAFGGIGGILRYKVEGINDFSDYESIDDNEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ8</accession>
    <name>A0A4Q9LVQ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0626p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000626">
        <property type="protein sequence ID" value="TBU12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0626p0040"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOG1 N-terminal helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar GTP-binding protein 1 Rossman-fold" evidence="3">
        <location>
            <begin position="242"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="528" mass="61249" checksum="7DA6BB1F8F46E038" modified="2019-07-31" version="1">MTFIFKSIPPVLQHTELIDTSLNKTQRQTPTMIHKTTPLPQIRRFYSTKIKTAASNFTSHLSSILTSFPHIDNLHPFHSTLLSHFYNKDTYKIHLSHISTTISYINKTASHFLSLINHTTTLFQSKTLKKAALGKMANHIKKLKNTLQYLETIRQHMSRLPQINPTTRTILLIGHPNTGKSSFLNTLINISGKNDEYKNIAAVHSYPFTTQNLTLAHFVYNTLSFQLLDTPGLINSTEKNSIELQTVIALLHLKSVVLFFIDLSESCGYLVEDQILLYKNVESLIGNNVIIVLSKNDLEECKKYENNVFKEFIENKKYISISTVSQQNIEDIKKMACEMLVSSRIEEKKEILEKSSNRLIMKGNSKKEKSLCCLKKEGEIKEEIETVDVVIPEFLQGKNFTDFIDRHEEALNYLKNGDFDVIRREYDLLSFEEKEMLKDIFNEKKKRIILHLEKSRSKLPEKWKNIPNNSENIDERIEDDSNTRNNGTDVLDIVRDNNKENKTGEKLRKENEYRMKHHTSSKAKHLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS5</accession>
    <name>A0A4Q9LVS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0617p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000617">
        <property type="protein sequence ID" value="TBU12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0617p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="24488" checksum="2D474DE0CF12B7A9" modified="2019-07-31" version="1">MIKLFNETFGRNTYYLFGNYNLYIIDTIGSVLYEEDTLIRKTTLKTAMKQYIISFGFSCDPALYEYIIMSYPLRNFEFKSFSHNTEFHYFLSLKNKKDYDYKFKILLKHSYITFEFNFNWCNAEQTVNKWKPKSFFYLCVTNKNDYEMMEIVRKSDPRYFILKNVSSNTKYFLDFCLSYNNRERERVDLERAELRYSFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW71</accession>
    <name>A0A4Q9LW71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0568p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000568">
        <property type="protein sequence ID" value="TBU12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0568p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="760" mass="91272" checksum="AE5FA670D9B74DEE" modified="2019-07-31" version="1" fragment="single">SFFVINEENCITDSNIDNSILEATEYENYSVECIYEQEEIKVLKNNTICREYTPNQFKYYNPNIFTIIYRKNMLLNSNFVKTAFESKQTNIRIFFRDISYNALLLFFKLIDKYDIIVNQIKTQDFLDILLILSVLDIERTKESNHFIKELFSNFIFEMQNSNHVFDPQKYYNSYHYKYIKKSILIELYIILIDLISFNDKIGHRYTVHHETIASNFKKTITAYSFNNMHPKSLTSQIYLRLNNISISSLHKIINSEYLMNTWIFLLNIAKMDLIYFIFSDEETYNKSIKVFSNITLHTEKLYIHFFEEPMKFFINKNINFFSENLKVLKLRYNFTTEELKNILRFCNRIERLTIKTYYIDFERLSLLVNFSMNNPNISCKILGFVYELPDIDYEFINNIPRNILFYFENSNRNVEYEEIPAKYMPFFQNYYFHYKQILNSRITIKPELLEFFRVKSVTLDFESNSSPYKIETSVFNMLRCFKTIKYFSLQNIVISNELLLYVLESDTIKILTITKFICIDKFRYISENETLFNRKLVDFLLFDSLTEINPSIFIYLSRFKNVSGFNFTIINENRTSFLKKIINHFFGTANKKYTKTYLNCLRIETNLNYIKKINFLEFFSEIYDFSKLCKIVYHVYEIGDIEYSIISKMTSLKFISIGIYNSKECINYEKLFNNGELFNTIEYVGIYVSQIRKRDIDILKNNKNLKTLRISCETIDYDTILGIKKNDFKNTMIIFENPVRAKRSVEINNYLDSEFQINFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW90</accession>
    <name>A0A4Q9LW90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0586p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000586">
        <property type="protein sequence ID" value="TBU12914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0586p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="6958" checksum="12C7B37C2E37A382" modified="2019-07-31" version="1">MDGISTIYHKMNPIFIYESVVLFSIGIFENTKAIAFVRQRGLEFEQNSEENWRLNPHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU7</accession>
    <name>A0A4Q9LWU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein Msh5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0493p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000493">
        <property type="protein sequence ID" value="TBU13239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWU7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0493p0030"/>
    <dbReference type="OrthoDB" id="2188923at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="47669" checksum="A90C180F92D36F46" modified="2019-07-31" version="1">MNDLDSELGDILTQIYDIELEILNSIRNKIVKERRRLDSLIDYIAIVDCINSLATSVIKYNLKKSDITDKNIFEFKDLRCILNFDFYGFDFTLDTNCILTGPNSSGKSSLLRTIGISIILNQIGSFIPCKQASMKLFDKIFTKMASNESLNCNRSAFASDMSLVREALNYGSSDSIFLIDELGKGTNIIDGTALFLSICKNLKDILVISTTHLMGWLIDNFNENKTIEVLNTKETPSNASDQNTFNTKYAVSSDENSKSTSIEVLNEIFNCKRTKIETENNRNTSDSSSQIISKDKELNNLELSYINESACFKNKNIFITKSKDDLSGILIQIFDNYCFKMLEKQTSSKKYTIKDGICTESLGLELMHKFKYPGSFYDECIELKKKLSQKYFKNLNMQENDNNWAVEIINDVIFNAKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY2</accession>
    <name>A0A4Q9LWY2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0479p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000479">
        <property type="protein sequence ID" value="TBU13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0479p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020914239" description="Leucine rich repeat protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="90949" checksum="59A197D0CC3F8D27" modified="2019-07-31" version="1">MKFNLCFHFITLLYKPLSFVFIYYSSKRNIIFNVVNENEESYIALGNNDLKPKCLYQIKRDETNANYEKNCLERMFVRDSNRQYEQYCIEFIERIGLKFDIFEKFNNMNNNIEIYLCHHIKKSDFLICYACIISYRLPVHKMTIKKFYTILYFLEYFRVEYDNKLRNVIKNIWCSLVKSDEMNNFNIEKELFHFSKQGYFSHALFKKISQQYLKLLNNGKDLKFLFFIKEYEYDISDEYKSLFREDKKHTLVINDDQCLFLMFLNTLDIKYLHIKYLNRANSKSFCFILKNLKKKIDELVFFWCYISDDVICSLNANLNFKNLKKIVFIESRFNTSFIFRENLANINEFIFFEGYIYDRYTLDEIEEGYLNIAKFIIQSLKHIHPQHSIEKYIKENENIPKANKDFYLKLLNEDKFRDKVKITENFECKNKNLEFKCFYEYKGCFNNVSITFEKLNDKRFIITENTILEENIKCIEIRSSAIKSGFLRDILNIKGLERLEINNSDIFIENEIFINESIKYFSFSHNNSGSFCSFSSLQEIYFNKTNTIKLNRVVNQIFYITELDLWDINEMIDFIKRSEKNEKFDFEATSKDEENLKLSSSPLNNLFQNYEMWGIKKLIIRDFSIDNLDVKAFSNLCNLKKLNIVRINFRNISFSELFCASREYKIERMEFDEINISEKDLIFIANLKKIEDILFRSCDIQRKVYRWIKFLFNNEGYIELKYIFEADNLAAETIKFIEEKFNTNILLQSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX15</accession>
    <name>A0A4Q9LX15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0497p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000497">
        <property type="protein sequence ID" value="TBU13224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0497p0010"/>
    <dbReference type="OrthoDB" id="2199399at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="50" mass="5946" checksum="80B06738F421B8C9" modified="2019-07-31" version="1" fragment="single">MVYLLISFFKPFSFLEDLHSVELRSEHMLLQLFDCLEKSKEISTRRAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX22</accession>
    <name>A0A4Q9LX22_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0468p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000468">
        <property type="protein sequence ID" value="TBU13323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX22"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0468p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8246" checksum="CAF1881B72C674BC" modified="2019-07-31" version="1">MEVKGSLSKGVSIVFYMEYCILYGDRKGDILEVKGSLSKGKGVILEVKGSLNKGVSIVFYIEVKGSLNKTINKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX65</accession>
    <name>A0A4Q9LX65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0370p0050</name>
        <name evidence="3" type="ORF">CWI38_0458p0050</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000458">
        <property type="protein sequence ID" value="TBU13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000370">
        <property type="protein sequence ID" value="TBU13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX65"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0370p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0458p0050"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="849" mass="100275" checksum="B879AFE24A1F6EF2" modified="2019-07-31" version="1">MFISIDEIHEVKNFYASKIKYSDTIIIDNGSYLCKSGYSNSDKQLVFKNKYYKTKTENSIEHVTHASVKSMFDGDIITNFETAECIFDKIFEFLECKNVKNLILTECLNNPYFSKKNLIEMCFEVYNVEKLQIGHDFIYSYLFNRKRFVKSEKCVLIVSMGHFGTDVVVLREDRIVEKYKLNYGGKQCSEYLLKLLQIKNTNLNLKLSLKHTNYLLKYLRCALDYEQETLEMYKNLQEGKEESVVIGKPERIQTSNFDKIPKKIKKNSKFGKSKEKIIETSSVETTSSSISEESDSDENIEEEESEITEENYEEEINIEEENIEENIEESYEIIRENIEESNEKIEEKTKEDEKEERKNRMLYFSGIYRFKVKIEKCLKTLKSNFENLSEEYEKLSDINGYIEKIRNKYSKIKKEIKFRENIRNQLKNKKSREYNCKFKISYGMEFNGEEEETLAMKIVESEDMEMESVLTNEIQKYINILMEYDKNFKPFEYNVIEVLKGENTNLNGLFINIERLKAVEILFEPGIVNLTQPGLIEIFEHAFSKFEIDKIFVTGGFSKIENIEKRIYNEARKVGFNDIQVIVSEDPQYDSLKGACFSDIFPVITKEEYFTLGLDAIMENEHMLLQLLDCLEKYKDTSTRRVAILKVENDNKIYPSLIKNFIKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLYSNVNDSSRWLKKGNIRSRDEAVFCYQDRNVLWDADGVYQHFGKSNKTVDHLATRCEKLVIHDYNRLHEQEILDKKYADISDLTQRVETEKHMKYDFLADDLGLIYKFNAEIIPYVMPWNNIEYIQSIVLKKTVETISFDRRKGLDLEPNAEESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ8</accession>
    <name>A0A4Q9LXQ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0670p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000670">
        <property type="protein sequence ID" value="TBU12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0670p0010"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6443" checksum="D479F7E7C1670F6D" modified="2019-07-31" version="1">MVKAVRGCLIKTEPSVKEVILKISETEHYVIEDINETTLFVNYDCLDTLKSRKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV1</accession>
    <name>A0A4Q9LXV1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0645p0030</name>
        <name evidence="3" type="ORF">CWI38_0649p0030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000649">
        <property type="protein sequence ID" value="TBU12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000645">
        <property type="protein sequence ID" value="TBU12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0645p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0649p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445401" evidence="2">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="463" mass="52820" checksum="B1E4AC7F8FEE6AE2" modified="2019-07-31" version="1">MMLVLLYLLFNKNLIKCAQANEKVDKEVDGMKKRESLSGIRDSDYTEVLDVPESKPVQVSTNQLLMIEEGEKAATGGEIYENPSVFKGKEAVTGLILSENPNEKSGKHPVPTPRSNIVIQTTEALNDVKQDSSEVSDVFLGDDSSPKNSIRIEDNQILVKEGNSSKRGSISIKDEKIEDPENLQTREPKENEVKGGAKIENVGSDETNGAKISKEISEKDSDDIGGVDVVDNNKAKLKKESETDKGLNEEKLFGLVSEEEKEVVSEEEEQEVSEEEEEEGKEEEEEGKEEEGKDKEKLIEEVSKGESKGEKKEEEGEEEEEQEVLEEEEQEVSEEEEQEVSEEEEEEREEEEREEEEREEEEGKDKEKLIEEVSKGESKGEEKEEEGEEEEEQEVSEEEEQEVSEEEGEEEEGEEEQEVSEEEQEEGEEEQEEGEEEQENKLTVIFNWVFSPFFKLLSFFRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW5</accession>
    <name>A0A4Q9LXW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0368p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000368">
        <property type="protein sequence ID" value="TBU13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0368p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15138" checksum="0B7B8040C1FDBC03" modified="2019-07-31" version="1">MFIDSNQAKIVLWGIISYVMTWNGIVTKYHKTYVKRLEIPMNVEAYIQSIVLKKTVETIFFVRQKGLESEQNGTESWEKTSMGVIMRTEMHKEPTPPLKQARTDENINEELDLEEETTVVKKVEENAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW7</accession>
    <name>A0A4Q9LXW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0643p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000643">
        <property type="protein sequence ID" value="TBU12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0643p0010"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11462" checksum="BAB9A9B118BDDA25" modified="2019-07-31" version="1" fragment="single">MNMAYLSDNRDYLHQNQSNDSHYNEYNLQSGYPYSQLTNGMPTYIQNLNPVLGQRTSNNRSQPYSLPLRPQARYQHSGFDYPTYMGHPTYMGHPTYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX5</accession>
    <name>A0A4Q9LXX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0494p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000494">
        <property type="protein sequence ID" value="TBU13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0494p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17761" checksum="ED6E82CF14221725" modified="2019-07-31" version="1">MPKGISGIDPSDNIDAIKLSLSDNQKWMVFEFNTGYMCRANSKRGVVGCANKKENSKWMINKTDRGYSITYDTKMCLIKGGFDNRLTSMGYFVKLGKCETVDDDKYFLIEEISSRSKFSPSGYKKSLNKDSIEDKEHHMQDKYCPVLGTTHKQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY74</accession>
    <name>A0A4Q9LY74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pyrimidine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0013p0050</name>
        <name evidence="7" type="ORF">CWI38_0357p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000013">
        <property type="protein sequence ID" value="TBU05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000357">
        <property type="protein sequence ID" value="TBU13704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0013p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0357p0030"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051793">
        <property type="entry name" value="NADH:flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917:SF2">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(2E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="377" mass="43642" checksum="DA39A67A24EC8838" modified="2019-07-31" version="1">MRVCIIGGGPSGLFLAKELLKNNMHVHIYEKENKIGGLYTSSFLPEYKKTNTFFSEILNSKNIKIFDSHEIKRSDLFYLQNYYHAIVFATGSDKSKQLSIKGSKYCMKSSDITKWYNGFYKNIEIGNKICIIGMGDVSFDIVRYLLDSKNMFGTPESKIQADKVKSVTVIGRSTPFKSSFNNYSLSRIYDIQDLKIKTNIKSLNKNFYSKNMLKNAEIDHKKSNESTINYFDDYNNKDMNTFENPSHPSNNANIDKYFNNEEYELSVKKHMRRKKLLNTVKDIGSKILNLNFGCKPIKIEKKEDKYILKYNCNNRIYKKQYDTVISSIGNIKKNISDIKLKIPIFRIGWCVNPNGNLSQMKESAEIISKDILKELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA6</accession>
    <name>A0A4Q9LYA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0478p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000478">
        <property type="protein sequence ID" value="TBU13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0478p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="26360" checksum="C49EB3266CF23E55" modified="2019-07-31" version="1" fragment="single">VNTSKYLEEIISLAGKSKDFIVGHLKDAFNCLGIVISQILKELNYNPETGVFPQKIIEKFHKQNFMVELFYNQGKETITCDFCPSKNASIGNNYAFVFYFENSIQESIDNRFKTSYFDCFPGSLQNKYHQAKNIFEFIRLPQIFIIKNTRSDIYKKILIDNIICVQNQNYTFKACIFYINSNHFFTVAVHNSILYEFNDAVVKKLNIESIEDIETHGMPDILIYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR6</accession>
    <name>A0A4Q9LYR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0404p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000404">
        <property type="protein sequence ID" value="TBU13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0404p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="27169" checksum="A6BA949919F11C58" modified="2019-07-31" version="1">MLLQLLDCLEKHKDISTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEVTKKKLEKAQHANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKASVRLSDEDRNVFWGEEGMATRCEKMLGHDYTRRHNEVVLCIHLLLLNKYNHSVQEILDNEYAELRVDTRIKTDVKIRFNRPDIFILDKRQNRITLIEYDLLANELGLIYNFSVEIIPYVMTWDGIVTKYHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW4</accession>
    <name>A0A4Q9LYW4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0266p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000266">
        <property type="protein sequence ID" value="TBU17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0266p0010"/>
    <dbReference type="OrthoDB" id="10022853at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020344354" description="Leucine-rich repeat-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="107951" checksum="F4BAD5A88E354886" modified="2019-07-31" version="1">MIGTILRLSILLMNVGIFQINNSMYLRNVGVMAAVFSEPSEDKSDGPSMEGTGLDVDTDQEEKKPLVFEFIFLKEEKASEIDSEERNVTNINDRYGVADENTYLFRLCNGTHEIPQHATTHSNQEFINSNENKIECSEKIPMDDHFLLEIHDLSYHKDIIRFNTLLNIVKNLKLKIERKVFLHEYIVYRNFKYIIKLSDSQDDSFYDIPLNCFRQIIDTLNFLDPEPSKNLDEFLTKFYFKTKFFYKNREECFTNENSPLLNFFSGYTLRKCYQTEDEAGHANINDGFEETKQDSSGINSTNTADEFMLKKYCYDWPLGAYLSRYNLSLQYTDGVVTVEKKTTQVFTRDLAGKLIADNFYFRLIKGSFFRFNHACIFDENIVILSFFFTKRNILGLELSDLEYEPTIEERHPEHDHQIIKNASTSKNIEFPPENDTRQAVFNLMKIIPAFREIKTLKIKNVELDLFDLNALSDLQSLTNLEITSSKEIERILGKIILKNESLKNIVLESVILEENFFDSLKLISPEVLVLKNCKPPKECQVLNFQSEKIFSLFSDQASIFASKLHKFEIVGEKNIDPNFLKFLKKLKVLKLISCFDKILSVEFFEYISKIQDLEELNLSGNEFYSYFNVKIFSKMTSLSKLELEDCGIDFSSTVPSNLDKKEFKCALKELNLSKNKSENVFLFVNWFPGLEVLDLSEFCVEGNPNRTTNQVEVSLPENLKVLKLKKVKNSFFKKFKIQFHKKVESLYLRDSIWDFRSSPWCFISTKTLLKLDLSFCTLSATDVNELKCLDRLTHLFLYDTEFQDIDLYKFLDLISARYLEEIYISKEDLKITNVRLMTLLKKFSNLKKIFLYSVVIPEGSFDREELDQFCNLKLFFVGYVEKNAHESETEIEILNSYFKPGIVKTFKINATNGCENGNISIPNESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ48</accession>
    <name>A0A4Q9LZ48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0239p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000239">
        <property type="protein sequence ID" value="TBU18509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ48"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0239p0050"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="19442" checksum="D10F625D93C19206" modified="2019-07-31" version="1">MTERCIELCEISKDHLILDLGCGTGISGCVLSQYEYIWIGTDISHSMLKICKNKEFAFDLCRSDIGTNFCFKKNTFDKIISVSVLQWLFHSYSSTHEPFLRINIFFKNLFFVLKNHGQAVLQFYPENSKQTDIFIKVARKVGFQGGLVIDNEGTKNKKYFLVLRVFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA3</accession>
    <name>A0A4Q9LZA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0224p0030</name>
        <name evidence="2" type="ORF">CWI38_0483p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000224">
        <property type="protein sequence ID" value="TBU03836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000483">
        <property type="protein sequence ID" value="TBU13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0224p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0483p0020"/>
    <dbReference type="OrthoDB" id="2193787at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="255" mass="30421" checksum="24D3F2A4A0E51A1C" modified="2019-07-31" version="1">MFFGDPSKEEIDLYLSDIKYSLINNPNLKNEIITSQKSFGNKKIERKNNFFDKIKAYEFTEPNVCFKNIKMNFDIKKTRNTSVEDIVTQDISSEIIEKMEKEFSSRRKSKKKRKIFGNSRNGILQPKNLNVPFRIDKSKMKELRDLTRKNTLKNTGYKFVRLESKLRTVFYSYEDFEHEKNKNIEDFVFKKRKVRFIDRNTNRLYHNEGDPIPIILQPKEKTEFVEPDTIETVFIENILTIPRKVSAGEFIFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZM0</accession>
    <name>A0A4Q9LZM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0503p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000503">
        <property type="protein sequence ID" value="TBU13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZM0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0503p0020"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21788" checksum="3E3A84DE0426676D" modified="2019-07-31" version="1">MQKTKTEKKRLKRLQVRKTPVTKNIYRVGLFDLFTKISDNTDCEVIKKIAHRLRMSRSNQHPLKVSNIVRQLDGKSDKVAVVVGKVLDDERMIEIPGIRVVALEFSRTAQKKIEKFGGECFTLDRLFKVVKCMEDVVLMSGDRTNRKAFKYFGVTGEKYSKVYPRVCGKKRQGKERRINYKPEPVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR1</accession>
    <name>A0A4Q9LZR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0194p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000194">
        <property type="protein sequence ID" value="TBU19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0194p0030"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="40948" checksum="D50D6B8AB8E98F81" modified="2019-07-31" version="1">MDQDIIEELGDYKIIKVLGRGSFGTVYEAERKDNRSIYAIKAENMHAHPDQSMLKNEYTVYNEMKGLDGIIDVYYLGLSNDIYYLVMDKLGNSLEQIYEERNRNFSLKTICMIGKRMIDIIKGIHEKGRIYRDIKPENFLLSLDKKNIYLVDLGMTKRYVDLYSGKHIKLEINKKLTGTARYASINTHNGLEQSRRDDLESILYVLIYFSVGSLPWMGIHASTGKEKYQLIGKKKNEISPETLCKGIRGSKYFIKCLKYIRSIEFEEKPDYDRINFYFDSLMTSKNLENDGIYDWLVGYTEYETLNMYEDKKDVEICNIQGGNNRNKKKKKGFWKKLKSFISECGSSNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M045</accession>
    <name>A0A4Q9M045_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0165p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000165">
        <property type="protein sequence ID" value="TBU19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M045"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0165p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63078" checksum="9F61F6B52A75F543" modified="2019-07-31" version="1">MSKKIDRGILQGDIQTDAESHSTNHLLFIDDVKLLAKDSSTLNAMTGEAKEFLEVIGLEINKEESATNDTCCEDTATLLESVNSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINLHAILLRFEPADLFKFNDAVRVLLVNNKIHLRPGCKERFYLPRTELGRGLHSDCLEKSKEIYTRRAAILKVENNNKTHLALIKSFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAEFCYIQDRNVFWGADGVCQHSGKSATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNRMTLIDDGITSKDSLQIFGLIYKCSVEIIPYVMTWDGIVTKYYKLCLKRLEIPINLEAYIQSLLLKKTIETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPTPSLKEEKREEDGAKNFKPKNKAPLISQGGTTLEEPTNNINKESDLEEETEVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A7</accession>
    <name>A0A4Q9M0A7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0157p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000157">
        <property type="protein sequence ID" value="TBU19995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0157p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17309" checksum="2105ABA33AAF7C05" modified="2019-07-31" version="1">MRAEIEMQIYKVIFLSKSKILTTFSDIEDNWKCKSQGHNLIDFRTGYIENLLIFESIFGEILVHGRKYIIKGGKNKEQEINIRLDKYKISETKNVYERNNDLIEEKETATSEATHAKTPNSRMSQNNLMRLVNIGSQRRTYNFKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B4</accession>
    <name>A0A4Q9M0B4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0271p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000271">
        <property type="protein sequence ID" value="TBU17665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0271p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="235" mass="28055" checksum="560188654905A85D" modified="2019-07-31" version="1">MIATMKCISNMKINCGTMHIIGRMVYGAMNKEKKQKKQWEDDFTHSMIEHRMSIILQYNLNPHYTRQIEQNCFVTTNTFEDFFDFHYIIEPGFRCIKESIFDTIDFLTTDEFTEDIYKRTKEYFKKENNESENLIDEVISKFNSLLIEKLKSYLQDKFAQAIKRDKNNADLFEDVFLALQERINTFIVQFKSKNNPKLIEAVQDNKKMAIRSNILEVLKSKFYLFDCVENLISQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0B5</accession>
    <name>A0A4Q9M0B5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0138p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000138">
        <property type="protein sequence ID" value="TBU20064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0B5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0138p0010"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="822" mass="95217" checksum="E8BB7A7C9520316F" modified="2019-07-31" version="1">MNMAYLSDNRDYLHQNQSNDSHYNEYNLQSGYPYSQLTNGMPTYIQNLNPVLGQRTSNNRSQPYSLPLRPQARYQHSGFDYPTYMGHPTYMGHPTYMGNPTYMGHPTSMGHLTSMGNQTYMGHPTSMGHLTSMGHLTYMGYPTYMGNQTIFQQDPRYDYIWYDPLTGAHFESRGPPNLNQSNSIISDTNATIARNENPTNGNIPISNSGLHGTDEEGNGAVDGEVNSELEEGIRGRTDVTDELSTSHNKIALTPSGYFSSGQTPDVEVHTIQQNATEPDIIVTDSDSLSKINSTPLPFHALKSQIIISKVKPTRASRNKNQTSSKRHSHKEDINENLKDLFLKIEKYVATADNSDLLWSSISEDKQIMDWAKIKKYLREYAITKFQNNNEFCLITIKKLQSHYEKILKDINESSKWVESEREGKIFKIILNKKKSKWKQKMLQINENKTSIFQLIFYNLNKILMNLSPPRTSTTQTEARSSDFEVSIEKLEDFLNQEIRNLENLNTEISDFSKICSSFVHYERTIFLNKDKNEIVNSFPILKIEETLSKLETCMKRNIVYEILAFIYLHKAEPLKSIKKYHVISTYFILKALYIHLDKLRYLDYYTHSTSPKAPNSRYMMGSKIFYIGQLFEKLLRNLENSESKADSYGILNCLRFLFTVTRIGGNNSGMLKLQITTVIAMVIDESFSFDKNKSIEFAAFALQIMDITTNKNGYFHNNKFEYFLEQNFSFFKNIKADERLYCVKDIKIVKSIADSWNDLIGKFRQILDQSLENETNASRSLRFKEIYIWQLYWIVINRNRAQVFYMDIAKRMQKVKLLLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T5</accession>
    <name>A0A4Q9M0T5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0230p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000230">
        <property type="protein sequence ID" value="TBU18741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0230p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020671257" evidence="1">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="452" mass="54201" checksum="6A9F74489F733A64" modified="2019-07-31" version="1">MKFLRKFYCLVLLYLVQFVFDSSLFNDPHIDYLYGEISKKIKLIFEKVLPKYITEYTNNELYTINLFGLDLSLNRFYIPDYISSQMYSESRIFFTEFICSKEGVLIENRNKLLFEILKSYRNEQKKINLRAYNQINGRDLEFEFISKTNTFEIVNSKPSISDLRNEILEKLKKYESHVSEHIKNKIFKIYIITPFVLKLIDTKVLEYTIKEFLQVHVIEKDTVILFSRQINDVHMSINKNISYNHFYQLLRKVDSPSNFSVNIEKRILFNKNTCEVYQDNVSDQNDIQNGIIDDLKSKNISTISNLDLKDPMSLIQPVSKPNSDAQILPFLDQSLSFLDLSSSEERRIYREFSSFRINYIFRIFNTEIFRIKLYFQMEQNGRFRYFTLDPIFPRTKQFNQVSTIQYELATQNLQFKYYDGINHRRDSIAIFFYALNHRFEDEIESLIRLSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X6</accession>
    <name>A0A4Q9M0X6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0103p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000103">
        <property type="protein sequence ID" value="TBU20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0103p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="22006" checksum="C4C14D528510DF1A" modified="2019-07-31" version="1">MYDCGCYGVCAHCKPCYSNPSLKKSKRKKISSKKSVKFNIITPQDIKREACTGVHKSTNGSEHGICNQTKNEQNLITLSKLNEGNICIHMNLAGFGGKQRKKVPKQKKKERIPQESESESKEEEEEDQEEVEDQEEEEDQEEEEKEENGEQSVTTVHQTFQASKTISNVGESPSTTEAQISSSSGSSLISVPPTPPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Y8</accession>
    <name>A0A4Q9M0Y8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0093p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000093">
        <property type="protein sequence ID" value="TBU20299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Y8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0093p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27245" checksum="2EFDE20094DD0D80" modified="2019-07-31" version="1">MTNINITDITEVNLLVLHTVLTMSQPKIKSEEDRERQGIALSCIGFEKVLVKSKKKFEDENRKSSDPNTKTDESKITELVPFKDIIEKPIDEKALLLRLESADFSKLGNTFREVLIKHKSASILRIEHRRNLHNLLDCAGENKELYARRSIRPKMGNSNKIHLAQIKGFLKPKYKSEEKPRRKVWEAQPIEIYSEIENTKAPLKVILSRKNELLFEPSNKPMFCYDDIYHSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M114</accession>
    <name>A0A4Q9M114_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0351p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000351">
        <property type="protein sequence ID" value="TBU13725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M114"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0351p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="297" mass="35443" checksum="93240A0E2A03164C" modified="2019-07-31" version="1">MTLIFRKFYIDRAIRTYGDLRFSFSNYRFMIFDPEISFENVIDLPDKILVFNHSRNWPRLISTANTKLKLSGKLPKISCIEDQNTILKEKVMIFSQLEHDYHIKSFWRFKNICSEISHSDEPNKIIYFYSIMTFKTDFILECATSCTSSLSSELIAKEYYVRHIITTYASIESLEFRKEIIIDFSLEPDQFLITFFLKENTQFEKKFALDFSLYLSNESFEISSDHNLNITNIVDKVNKFEKDNYEFSFETASIDDYKKIFEEFDYEAININKVLVCRKKKSLSYKSQFKRDLNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M163</accession>
    <name>A0A4Q9M163_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0749p0010</name>
        <name evidence="2" type="ORF">CWI38_0072p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000749">
        <property type="protein sequence ID" value="TBU01292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M163"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0749p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="239" mass="28392" checksum="6055F476A7BD6772" modified="2019-07-31" version="1">MEKLLEVFIKEIKESHDVDIVVEWCNKYVKEYYSKESFHYDLINLLKSKNVNEKDKMEILNICINLFHFGYDITNKVCHNKYTNSDARSINVVSSMVCWGIIGKILMKYFDDEFYIKATEIFDDASFYFCMPNKRNDEMNYFQSKARLHFYTKVYLPLRLRDLIIGTNVTNNYLENEPAFVCKYLVDILKENNIKEENNFNDLISYFGKLRFEEMNSIFKGVSLENLKADGKKNLSAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M206</accession>
    <name>A0A4Q9M206_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0031p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M206"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0010"/>
    <dbReference type="OrthoDB" id="2186070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20912" checksum="6AF6092694A178F5" modified="2019-07-31" version="1">MTATQILKTQYLKDIVIYNLLTNGIYNTNEIVNIIEINEYLRDIGYEAIYWYDKSCIILKNTLFNSEHTHEYLKSNQIEEIKDFFKNILISDLSETNYKKYSMAKFLIQKRWIEIINGKAKMTKMCLIQNTEYLISITDKCTKCSLCDIIVLNRNTHEYCERIYNERICDNIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M275</accession>
    <name>A0A4Q9M275_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0099p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M275"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M275"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0020"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="831" mass="97698" checksum="615AE4C11DAD3523" modified="2019-07-31" version="1">MDNDFIPDFTLKHSLGEIVNKKSVIQWDGTAVLISLYNRLVMWDTRKFEIKYTFGDSFKYIITSFCKVELNGEIFYYIGYEDGTLKVFDSENNKTGHQKLFNKKIVSIVFANPYIFIASKEMKILKFDIQNEKIVASYSQIMSPIMKLAISENYIVTSHTDKYIRIWEINDTFPYFIYMFDNEIHDFEVYKHFIIVFLKNGSGFVINIFEKSIISWQKFKTFKRVKVFDDKLSILAKNKIFIYELSIQKNISKEIENKEIKNTSIYIENEEEKLENNDFETLIKKLKKEETKENLNIQDCKIEKTILSIKDSLNKKVSENCADIVFCNNNTIMLTTSNNMFLSINILEDRTSSFNFHTKEIIGLEIYKNSIFTLSTTEIIKWEIENEIIYMKNIINLEIQAKGMCILQEVLFIWCEEGILGFSTNNFELLYKKKLFTTAIFSRNNYLLVGSGSHLKILKLKKSKNENLKDNKNPKKVVDETCNKNKNLKDSTNLINVAKETWNENENKINLKDSTSLIKVADETWNENENRINLKEKESINVLESICCIYMSKDETLIGVGLMNTQIYIYDFKTLERKVSLYGHSLPVRNFSISEDNKQLISCGSDKLIKIWGIEFGECRKSFIGNSSNVEFLYNDTRRFIFCDENIKYYNNFDLLKEFRSFDNQLAKISKEFMIVCGKFSINLYMMNDYEYLPVESSNEEEDLRNEMKIVNVKNYEKFYDFIEEYEENKTKENLERLCKFLKKIPLLEIEKYIQHLDSFGVNLILECCILIVNSNCVIVAKIFNSLIRIHKNTINKELSDKLYKEILKNICSLKDSIGSTLSFIDYTINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J7</accession>
    <name>A0A4Q9M2J7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0009p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="671" mass="79217" checksum="F5CE2141D00F8A77" modified="2019-07-31" version="1">MVFDRNKEQNNSVLENNNCMFSFAKNNESNTSLRFQSTIEVCNSTFPEERYNPRVFTNNSCIFSDCTYDNISERPENSNYGNNQRHSRSTSHPNLFFDCEKRVNSAYYSAHDPNIASAEISRASENFTQTLNPTVSTPLNYRYIPIYETRHKSFENKFSQKYLDQRMMPYQKSNESDSTSYTCEPYVQNQKLTIPFTSEKKTDSQKRKRQIISLDPSNIKKKCDGLHSNSEPSNQLDSLSPVMLFMSDENLINNNSNEIKFPYYELAGETLSIFMDKKNKKYCENYEYFLSFIPGLFLEIETVSEEDFLFNQIHSNSILSHLSSDNWNKYIDDKIENYNFISIDSEVELKKISTFSEGLIFYEKNVPSHMKNAHLMPLYEKMTFILLKMKSEDSFGLFYELIKFETYYETNLYNYIEPNHNLYVYYILSIILKQLKHINSHVFSDSNIYNRKKILCRQPFNSIQKQEYNKKLFVQRLFSKLLLGMKNGRLRSKFYNVALILDISSEKHRRKYYFNQTSYFIFFLRVFTSFVLEPNFNSNAESLDKFCRLSLDIINLSRSLGDRFLEKLAFMMENFNSGVFTVKTNIKLIRKFWGCDKDRIRLNDKLIYLYNKNNVLYGSPSIPHMYFSINDIFLSEICLSACLSRIYSGICFDEGVNCYGLKVILEKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Q6</accession>
    <name>A0A4Q9M2Q6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0162p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1383" mass="159560" checksum="D57105F835368071" modified="2019-07-31" version="1">MGFLICLGDKDYNCVYHIKGVKGYLVWDIKSVSSIEGVSDKDSIQQGVSNNIDEQHLFINNPYKQQGVKSSTNKQQGVSSNIDEQHLFINTAYKQQGVSNNIDEQHLFINNPYKQQGVKSSTNKQQGVSSNIDEQHLFINTAYKQQGVSNNIDEQHLFNNTPYKQQGVTGNLFLTHKIDGYFAIKNVFLNFSEKSKNIFLTKKGKFYKYLLKSPLIRTEDSIISFINTVYNKIDRSKDIDMGIVINRDIDNNIDNNIYIRDINTNIGTNVNSKGINTNIGYKDTTTNIDTNTNNSKGINTNTNINTNIGYKDTNTNIETNANNSKGTNTKDTNINTNTNIYNINTTSPLKNIFFFTDSFIVVTDTSIKYFENNFLKSFSLKFRKNIKEIKKIKDLIIVLTSKEIDIYLDIEKERDRNTGIRDISNTKLNTSNISNISNISNISNISNISNISSISNISNISNNNNINITTNISNTNISNTNISNANNNILTIDILYHCYTSTDTSIVLSYNNKIQIYFFDTNIEEKYILKTINVEFKIIYIQIYYNYLFLCTGLSVIRIFNIFSKKYVFIQIFKNNIILIKVINNKLYVVDDKGILHIINISMNGDKNGDGDIGSRDIGSRDIGSRDIGSRDIGSRDIGSRDIGIGDIGIGDSYNRDIGIRDSYNRDIGIGDIGIGDKTLIDNKFTGKKSISNNLTDTYKSNNITLSLPRSVNMCNITNIHNYGAECLLVGKNIFYLEIENEFKKIKIEFEKVFNFNGKIVVLKDNLLVAYVVRRIEEYVLSSVGGEYVGGEVDKIDNSDKIEDKVDEIEDKDKIENEVDEIDNSDKLEDKLYEIEDKVDRIEDKVDEIEDKDKIENEVDEIDNSDKLEDKLYEIEDKVDRIEDKVDEIENKVDRIDEIYDIPDKKYIPDTPKISYDTPLYRLVGECCMVIQVSINKCEIMCFDREKEKFCKNVNFYKENIFIEDFIDINVVDEHTIVLYRDSSGVSNKQYEARKYKDREYKDREYKDWDFKDNIFMIRVYKEKAVLFDYKINGECTSMCCYSNKIFIGLKEKVENPCYRILSNIMGDKNHRDGTDVNTPIARGIHNNTPIGDSITTLNNTPLATDLPNPIPNPNPLLQKHFLHLFEIGKKSLLLKNRIYLKSEIIIIKTNVKYIFIVTKRNSLIVYDINLLTPVIQDILHKHIIYLECINIDTIFMSDKLGNIFICKIGFGGNMNGGSSRDNAKDKTNMFNTDMTTNHNTNLNTYPNTYLNTDITTNLNTNLNTNLSFTTLISYYIGDIVIKIYLTKYKIYYFTSFHKFGCLYYLNEKEFNLYEILEEEILKRQKCFNNYNEYYNRFYCRKNVIDKEYLKKFYRFEEKDKLSVQSVLGSKEVGCMEMLIDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2S6</accession>
    <name>A0A4Q9M2S6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock factor-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0193p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000193">
        <property type="protein sequence ID" value="TBU19826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2S6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2S6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0193p0040"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24913" checksum="DD04A967958277A9" modified="2019-07-31" version="1" fragment="single">MKKSFDLNLKINKIPKFIKRLYKVVNEPTIKEIYWNDNGNSIIIPKKEEFIKNVLCLVSKTREYSGFIRQLNNYGFTKVRGYTDECEEYFNKNFLRNREELLNLIGRSKEKSGSTADIMNSYRQECYSLRNNVEYLNNSNYMLTKEVENLKARMEKQDRTMNGLIEVLTRAFRFGMKNENPQLAFSENKTHSELDKFLSEDLVDSSYELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T0</accession>
    <name>A0A4Q9M2T0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0002p0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0130"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="5956" checksum="92000F5D5A661F95" modified="2019-07-31" version="1">MGVIMTSEMHEESIPPLKEAKREKDAEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Z5</accession>
    <name>A0A4Q9M2Z5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit of adaptor complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0078p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000078">
        <property type="protein sequence ID" value="TBU20388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Z5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2Z5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0078p0040"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="1">
        <location>
            <begin position="110"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="387" mass="44684" checksum="3AE26B8784F6D99E" modified="2019-07-31" version="1">MYQDICIVDKNDILIYGVRRIENPTNVIYHDDIKIYISSKCHSIIQNYLVNEFIETLAGVIGNLNSKTLKSHFFDLLTLKSEINTNNLLENIKNNIDRKIETVKKFTNNESEIMLDVIEELNVIMDIKGNILRNNLNGKISAQKSKKTKNYFYLNLSVPQNLEFINLEDNIDTNSEKMGITEDCFGNEIKEYGNNCYDLESKNGSEDKKPVLDPILNNVVLLKQNTYLNANKIFSESKFQTPITLKYSDQCLIRYKSIPPKPPIQLTLEKNYILLSCRMKEINNINIKILLPYNSHSVSSSSENGKATFFEKDSIIIWNVTNIKNESAKLILNYQSFQNQKLRGILIDFECLFFSCTGLTIKDVGLKEKTAIWAKYLFKSGRYEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M324</accession>
    <name>A0A4Q9M324_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0163p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000163">
        <property type="protein sequence ID" value="TBU19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M324"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M324"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0163p0050"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="374"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="578" mass="65917" checksum="B6878652F080CFB0" modified="2019-07-31" version="1" fragment="single">KQQGVSNSTNKQDPVNNLSNTLPPFNNTTYTNNNLSNTFTSVRISNVRFTKSLIKNTKAFTYEEAFENIKNIKNKYSKDMNLLWKIVEIIRNERKKEAMDLSVGGILTNFLVEEIMVLTNSLVGKELIRKRGKGCLLRIHTESEAIRSMCTEGVTYKDSSIKGMEGVNYMDSSIKGGVGVNNKDSNLKGVNYKDNIKDLKDTKDINNISSKHHIIRPSNVDIKVWRSYMARCMDRAKYFINNGNIKELKHYGLGLDVYTHFTSPIRRYADILVHRQLYEVCSNNSGCDTINTEISNNRIENNTGSSITNRFDNNNDSPTNNNKNKNSSSSTNNTNNTITILSDCTVNRLNDKNYSAKVVSRESRMLKIYYQVSGSVMEGCVIGVKDNGVIIYIPDCDVEGFVKVEEENKYELFDNIRVKVGGNYKKFFSGRGYDFEIGMEGFLVEEDFYTEVFIYKVRIQRDLHVGETPECIECENDNVLKCLVEKSGSHDENLPLTTIPTLRKQKVFNNDRECIIEKTLKGHSMSAIASMYRINYQMVNSIVTYLKTGLVFVEKRGGDRRSKLPLEIKESLQTYVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M396</accession>
    <name>A0A4Q9M396_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0159p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M396"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020250355" evidence="1">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="21528" checksum="CD339304BC1D08DE" modified="2019-07-31" version="1">MNTKWTPILLTILKFIICSLNRKTKSIRSVKETNFNESTYIRYETVDDDVEISSLEIDKYSSPYSETKSDNISYSRDVCSSKDQINLSNNCRCRHLTSELYTIFEGKKIESCKDKNEPDKQKFARIRPKSESDLLQSSPWDLIEDFSDASTISDVSNKSVLTDGIIGEETLETLSPCQSPNSFIYQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3E8</accession>
    <name>A0A4Q9M3E8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0108p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000108">
        <property type="protein sequence ID" value="TBU20232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3E8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0108p0030"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23352" checksum="519F0DAEF0D5ECE9" modified="2019-07-31" version="1">MGTCSNRRCKRNDEDRFHDSLEDIYDKSPRYKIKIVIGDLNAKIYTEPYYRITIRRDRIPLESNNIAKKFIEENNNLIEGGETTVPEPLLGETIDGIISLKKNNAPGKDKKVLLTGNISSDFSINMGRQAKKIDSIIFNGIPQYIAYTDDLVIVGRKQEDRINFKNISSGIMKSRLKINERKPKYMDMSSIHEYPRNSFKIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M483</accession>
    <name>A0A4Q9M483_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0002p0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M483"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0110"/>
    <dbReference type="OrthoDB" id="2192420at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="717" mass="81481" checksum="6536EB27C12FF559" modified="2019-07-31" version="1">MIYLKNTENMFLTNIKNNLCLEKSTLDNIKWQNVVVHKRKLFFVTDSVYYTVAMSYKDIHVRIVEVKSFQEKRIGMYQTKKIVDLFGLNKKEESNANNGGGNGGGSGGNGSGSNNPGANPGSNSNPNPGANHNSIFNPTPSSNTNSIPGSVFNTNMGSNDSQRSITTQRTNNRLFSLNSNNMRPPAVPTITSYTQITKTKEKKPSQPKDNDENDEEDRNDRRLKQRKKKKLREDFHVDSDSSLEEYENGCVYKDAKIKEVDGKYFQLVVNEEFCVTRFEGKFIFAPCSENDGQYFSMARGNEILTQLKKQKENEMFLEVSKVGLLDNVDRNVERFNDFIKSKNLSDLIGKTDTLNLLKNQLLRNSNSLPNNLPNNTNSLRNNLPDTTDRSLSTDDLLRSANTLSDNTDSITRPNTPPDITDRNIYTEERSGDDTKNKMSLQNTQRLKQLLKTVNPDISDEVLNKILKINKNEPERQPEGEKENTFGFINNHNNEKINSYSEISNIKKDGNEITESIFNKESTINNKFTDRTGNSDDKTGKFDSYKINTGTDFVYPYNNSQPRNTTTPTYYNSLYKLPDKEITKEVKNKETVKFKLKDLSKRPSFYTTQKIEGKPMDTKPNNSAPLNLSKLITSPQKSLKNTEFSKNKTNIISNSYNKDKSKSNIVSDDFDSTFGNLKEDIAKTESMFGNLRSDTLEGSSDKEDFISKLQKTFKENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX87</accession>
    <name>A0A4V2JX87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1513p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001513">
        <property type="protein sequence ID" value="TBU10852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1513p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020701362" evidence="2">
        <location>
            <begin position="24"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="712" mass="81886" checksum="AD95D2C91136C3B8" modified="2019-07-31" version="1">MIISWLSLYLLFTYVMIVKPNESDSIQAPGSYIYTLYGNLNTDEGPNSGSGFTRTNSGGNGMDNSPVNGFNAHSFTNNYFPLDNPSVIGLWFGLNDAFETVAPVSMDQTNGTNDLADYTPNDSITFGNNGIEESEIMDQTNMDTNSTYQSTMFCGNGDSVALGSAAMEQNIIDEDRNSDMLVENQNHDNPLFLGSTVDEATKNGRQLYTTSLSDKDDLFFLDELDLVFISDAIESKIKDLGFFSFDFFMREIFSEGGDDVTESTDSQAIPKAESIFHKDQSGNSLLFSSNLSTMENNTLKESGNSTAVKSYSREFKAKLSSFLENIPEIKICSNYEKFLNMIPNLYKEIEDSVETNISIMEIWNVNDDDVLTFENYEDKIKKEIEKSKKIVLETDIFPEQISKFANKLIIFEKNNAKNINFPEQIQLISTIMEKIKNDKNLVIFYEILKFVYYYSQNLQNCIESGYILYVQFFLSVISERLDSFDNSFSTEYKICHHTLENKCEPKFLNEYLKKIFVQKLFCKLLLGMKNGKMRSRFYNVYFSHEICARTHHNSSAFYNQSKIFKFYLRVFISIVLYPDFNSEIEYLEKFIDLSFDIFTTNKFCKKAFTQSLEHLITNTSIKFYSMIKTNLEIIKPLILITAKNNGEFIINSFSELENKLSKNEILSMKYVFESEVCLSWYLNKQYQKHAFGKAENYTSWSTIEKSLFESCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA3</accession>
    <name>A0A4V2JXA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1461p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001461">
        <property type="protein sequence ID" value="TBU10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4V2JXA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1461p0020"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="5">
        <location>
            <begin position="1119"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1331" mass="150653" checksum="FFE8E814F2634DB7" modified="2019-07-31" version="1">MEKKTQRVKSVAFHHTKPILLTAHHTGTIKAYDYQTSSLIHEFNDHEGPVRTIIFHPFINIFVSGGDDCIIRIWSYNERKIITKLKGHTDYIRSLDFHPNLPWILSSSDDQTIKIWNFQSYKLLATLTGHSHYVMSAKFLTQDYIISASLDQSLRLWDCKSLKTPKNKKSIDILKVPEVIVRQILDGHEKGINWISVNPNTTMFATSSDDRQIKIWELVGEIVKERDVFHHHQGNVSSVLFVKNLLISNGEDGILCIYDLKNKKSKKIVIEDRFWCITTNRDNTLFCVGHDTGFKVFSVDRQTPLFSTLYTPTFSGIFYFSGNSLKFNNLKTERNIFTTKKEVTSIHSLGSRDNNEIGTFNNNITNTDNYIASTDNISNTISNNISNNISNNISNNTTDNITDTISDNISDIRLIIQYNNTFDVLKNNKLIFSGNGKAFLSKHGILTHYNTKVSLISNEGSIIKDSILFTEEEIIFKDENIFIILKNKSVSFMILSDSNGDSQNISNNILDISDSKSNTKYNKSSKYNTHNRHTDVCFIEKNISLNFKPIYCICKQDRVAVLGNKEVSILKLKEENLSTPISPVTISISIISTTVEPVGINYGFFYKEGFIYSTKRHLKYLLNSSDTGILKSLDKQIYVFYMCNDFVFYLTSRSSSSNGYISSGYSSSKSNTNNNTNNNDFIIENTKIDFTEFEFKLSVNKNEDKKILEIIRNGKLLGLSFLSFLIKNNKGVLVLDSVSNLEQKIEILLSVGRLEECLDIIREMGGKDKQEGVNNLYNKQQGDNNSTNKQQGDNNSTNKQQGVNKSTNKQQGDNNSTDNYHPLSNSTNKQHPINHTPTNYHPLNNSTTYITLLRRVLKEAFKRCNFTVCEKCLLLLNDTHGLFMLYICNKKINLINKIKNKNLEILVFLGNKREIERYIGSENSEGEDIGEGSNIVEGSSIRENNIVDNNIVDNSIDKTEDTNVGDNSIEDTNTDNSIVDTSIEDNSIDKTEDTNIVDNSIDNTKGTSNVNINSDCICVDRIDKSLLKNINFKEEWEIAMNNTTEGKFNVALQGLRVMVHNLAHRMVSGSNIYDSNKYSKDIKGGNDIKDSNDVYIENDITNINNNCNTPLLRLRLGAYISGLGVEKKKKKCLEVERCMEMSCYFSRLDLLEVHKVLALSNYMMVCFKNENFTMAKEVARELKGIIDGEGVSDKDRVGGVNNDTSKLEGVNNSINKQQGVNNHTNEQHPVNTILNKQQGANMSRLEKSVKRVLMSEKSGDKYFIGKGVFCYDLCCYKEEGVCCRFCGVYSYNEGVCECCEVGVVKRSMLEGVSDKDDSSIKGVSVVISKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH0</accession>
    <name>A0A4V2JXH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1089p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001089">
        <property type="protein sequence ID" value="TBU11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1089p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14025" checksum="72CE58102183C20E" modified="2019-07-31" version="1">MTVFSNSVKKRIKEKNNSECLKNEKLNSVNNSKKKIHEIKSGNTDSISKREKTLSPMAIIKLSNYDLKYLLVSKSLSHKNNLDVAQLAELYGKIEKRKFHIKLYSIQKKEVNVSDSTRWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH8</accession>
    <name>A0A4V2JXH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1043p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001043">
        <property type="protein sequence ID" value="TBU11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1043p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="33573" checksum="452878B867B868B8" modified="2019-07-31" version="1" fragment="single">VLSEVFFFFTLYPEKISNIIRQNNFIYVSFLLRIFALQIIKVLPKNQDDFESRYKFKNNLDNLIFYCEIFNLRKIFYNILLGFENFNRKAYFYQLLNILDFRQKLSLENYEVEEYLLFKSQLNTIFFLNLSPRFQIEDDVRYRKIIVLIGIVCYAKALNLNDLNIYLLRLTFSNLTNIFSILKNLSHVFLDKKHNIFYASLRESCERIYIVTRKEKIEKYSKAGESFPNPVSTEKYIWEFLLKLEQAIFKNYETNELNMEITDDLIEKVNTRISLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR5</accession>
    <name>A0A4V2JXR5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0610p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000610">
        <property type="protein sequence ID" value="TBU12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0610p0040"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="58470" checksum="B70E109A5B8D286C" modified="2019-07-31" version="1">MVLPLNRRIRRQNLFSDPMPFIYAIPYLDDILESNIYISKEDTQYSVLTNLLKLKRTDKDFCYSIYADYTNQAIYNISDEIKLNKLKEILDKNFTRYKINFPYLYFENIQDAIKCLFLSNSIFSFYLSKFFKNLPADSNILYCKFFGNKFVKHVVHDRDKIIIGPIDIQTDVLRDLINDISEIEAFSEYYFIDNYKIYNNCSIIKSDTETSFYISQSSNNKIKTGEICNNSKEIDEPNKKTKHFIEVTELNEIEDIEEEVKKLKYINEEVKEINEIEDIKEEVKKIEDIKEELNEIKYIKEEVKEIKYIKEEVKEIKGEIKNILKSKKNNFYCLSFKNKEATNPFLEILSNIEVEGIPLIAKRAIDNCYVLSFSQMIPEYTFISNTITTSLIKTRFVQILNFFDFNENLNFNFIETKIYNLCSQITEVKSIKIPDINKEGLLSHIKCENKGKIFVECISIEGAENICKKIGGSVFENRLIICSFYSELLYICNDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS6</accession>
    <name>A0A4V2JXS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0184p0020</name>
        <name evidence="2" type="ORF">CWI38_0572p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000572">
        <property type="protein sequence ID" value="TBU12962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0572p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18822" checksum="43267FBF663AAE52" modified="2019-07-31" version="1">MLFLICFRKNKKIFYISIFILVCIILTIFGFIYYLANCVQVCLEHTNFIQNLKNGNNMLDTKFNFQNNSVFDLSISDISIEYKNNVESEDVYIFNEQNNKKLFIEIKIPSKATLEKRIQFIIERTIDKNELKRSKIIVAIKKWKKTVLKISIPLEEIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY77</accession>
    <name>A0A4V2JY77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0137p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000137">
        <property type="protein sequence ID" value="TBU20073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY77"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0137p0050"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="19593" checksum="0D5D2FA2E1C1DAA2" modified="2019-07-31" version="1" fragment="single">FLNENIDILKSRNEDILKDIYKLVMTYISCEEVRKELLVTIEIYFKYFKLRKIYIELLPIICTMLGDEAIQDSVFDLIENILKFMKENKKELLVKNWNVKSIKGFFGFMKGNKEEKSSKNLTVINKKVIDEGILEKKVANISFQDKEKYNEEDEDISNEWNEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB0</accession>
    <name>A0A4V2JYB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0084p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="12058" checksum="8241145A879802DB" modified="2019-07-31" version="1">MELEENKTELFKEFIKVASSSEVLRYARKLNNEELKSFIQILEERNNELKNKHSSLLEDLEVSKNLVSQYLKVLWRRVPTEIHKHLADKFYSIHNEINDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC6</accession>
    <name>A0A4V2JYC6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0691p0020</name>
        <name evidence="2" type="ORF">CWI38_0040p0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000691">
        <property type="protein sequence ID" value="TBU01522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0691p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13771" checksum="287BD4E38D976CBF" modified="2019-07-31" version="1">MIEELESTEQPCVNKIINGDGYTYIIKIPNKIKKENIKVEYDKCSFKLKYKKTNRSDSEGAICSVKNEGTFYRKFDFEIKNPNIEYKDGEVYFKFSKGNELSYENKEDRKVHKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVH8</accession>
    <name>A0A4V6MVH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2337p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002337">
        <property type="protein sequence ID" value="TBU07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2337p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020869706" evidence="2">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="30029" checksum="2E960A0E013C121E" modified="2019-07-31" version="1">MLHLFVAIIFNGCGIFTSDTPSTTIEEKSHNERGNGKESLVKAKTGYTTERILYSIHNSRKTSVSESENLIGNKTQAQPSSNTKTHKSIFKGTIDGTNAANPLKSSKIVTFNEKEPSQIWIFESLNESSTDFNKGNLSAENKDTMPAKHISPSFSQQKIPDESKESSTDRVNQVLSQSSCEFFTHTPSTVIPVYKIKQCSSHVEEPIIVSKKRNPSNVHYKNSPNPQQKSKPKFNSENEYGKFNQDLKNHMNNFLNRKPEAKRTPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTG8</accession>
    <name>A0A4Q9KTG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2389p0010</name>
        <name evidence="3" type="ORF">CWI38_1755p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002389">
        <property type="protein sequence ID" value="TBT97259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001755">
        <property type="protein sequence ID" value="TBU10446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2389p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1755p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="93" mass="10126" checksum="13060202A096BA36" modified="2019-07-31" version="1">MSRTIISDVDSIASDSEDGEIGGDTSSDDSIIITHRRKRLRIESKSSISSSSSEAEETPTFTNIPPTNVFSKATNNFFETPGPRCAPPPMLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUA1</accession>
    <name>A0A4Q9KUA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1796p0030</name>
        <name evidence="3" type="ORF">CWI38_1817p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001796">
        <property type="protein sequence ID" value="TBT98346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001817">
        <property type="protein sequence ID" value="TBU10368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1796p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1817p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="90" mass="10294" checksum="BAC7EC70961BD5E9" modified="2019-07-31" version="1">MSLLSTSLFFTSGLYLSKYIIKKRINKVVPCIGGMSLIYVGSMVEKDNLITNKEINYKRPGYWLIGSGIAFFGITYGTLVHRVYQRFLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1W2</accession>
    <name>A0A4Q9L1W2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0720p0010</name>
        <name evidence="3" type="ORF">CWI38_1039p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000720">
        <property type="protein sequence ID" value="TBU01393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001039">
        <property type="protein sequence ID" value="TBU11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1W2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0720p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1039p0020"/>
    <dbReference type="OrthoDB" id="2191625at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="319" mass="39010" checksum="174C2356F15D041C" modified="2019-07-31" version="1">MKILRKELDRTVDEIYNEYEDLALSEQKLSKFNSISEEIENKIIEKEKIEEELRIIEDQIKPFDFIDFLQNQTEKFKNINFETIITLFEEIKTANDFFIEQQDEEYISKCNNLNTELKNYTLQSIFDVIHHKPTTFFKNQFILKTFPYFTFEELNKIKFKYLRMRKTKCQEKIQYFREEIAILLKHTIKEEFYLYYKIFEEELPYTIKYLYSIEDTNLYSDNQATQNIFECFVFSVLRDFVSNLDKEILEKFILENQNEIISIRKSEDTKIKSEIFKIDEMSEIERYYYSLIIFNVSLSKFYRLFDQKEDSINDSVFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L577</accession>
    <name>A0A4Q9L577_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0424p0050</name>
        <name evidence="7" type="ORF">CWI38_0123p0050</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000424">
        <property type="protein sequence ID" value="TBU02729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L577"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L577"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0424p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0050"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU02729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="138" mass="15009" checksum="88E886FEA008C31B" modified="2019-07-31" version="1">MTEEIVEQPVKQLNFGVAHILASSNDTFIHVTDLTCSETICKVTGGMMVKADRDESSPYAAMLAAQEVVNRCKARGIDAVHIRLRARGGMRSRVPGPGAQSAIRALVRSGLRLGRIEDVTPIPTDSTRKKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7Z5</accession>
    <name>A0A4Q9L7Z5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0292p0020</name>
        <name evidence="3" type="ORF">CWI38_0854p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000292">
        <property type="protein sequence ID" value="TBU03456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000854">
        <property type="protein sequence ID" value="TBU12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7Z5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7Z5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0292p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0854p0020"/>
    <dbReference type="OrthoDB" id="2188827at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="308" mass="36039" checksum="4D008F525857359B" modified="2019-07-31" version="1">MKKENSTEKSSQKETDYKKGDYKETDSKKGDYKEGDYKESDYKESDYKDPLKYIKDATNTVDKYPEGYYGQYGENTNYGALEDFLCNLCQGNGSINVLSSDTDQEMGKKFTTFECKMCCIEDANNKNLPGKDFKGLLYITCHFDNKKDLERCILLKEKSRVYFTMNNVSYKYEPDSDMVTTVEKLIRQASDKISFKYNLYYPKYKDPKESYPHIDEKTSSGDQLYSDMKYDSKSGQEKETEQDMYKDSNAYVDFFDKILKDGCLKLTIKDKTGLSRVCPPHKKILDSKYYDIDSYNEEKICHNLYMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9U5</accession>
    <name>A0A4Q9L9U5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0125p0010</name>
        <name evidence="11" type="ORF">CWI38_0166p0030</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000125">
        <property type="protein sequence ID" value="TBU04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000166">
        <property type="protein sequence ID" value="TBU19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9U5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9U5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0125p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0166p0030"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="178" mass="20883" checksum="A24AAF4912290E99" modified="2019-07-31" version="1">MEQLKKKFSRNPIKAEIYKLSDIKVALDDLLYQFLKYEMKYKQCNFVSNLRIFIGMISVIITVIIAYLSVNQDFKDYKQLCVAGVTTYFLINFLGDFIIRITGCSKYIFMGGSTEENFKISSFTDVENATYNLLIYKDAIEVPRKYVKKVNELFYKDGAMIHEIFLEDLKNLFVEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE75</accession>
    <name>A0A4Q9LE75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2708p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002708">
        <property type="protein sequence ID" value="TBU05775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE75"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LE75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2708p0010"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="48429" checksum="DC07775A95536461" modified="2019-07-31" version="1" fragment="single">NTHTYTNPYNNKTFNLNTTPLTNTLYIYISKGILFESKINYFISDNLYEEFKIKRKSKGITYCEKEECIIIAGVEETRFRGSDIKGDGDISNRDISNVDINNVDISNVDIDISILDSNRDIDSNNNTNITTNTSFINTNINTNTPPTPNNKNNTNNNNNTNNNNTTNNTLPLTYSYSLDLYRCNTLIDSYKLQLNEYICMVKYMLLNNTQEVLPYIIICTSYIKGEDNICKGRLIILKIKSVIPQINKPLTTLRLGVIAIENTKGPVICCDVLRYKIVVCIGTKVFVYEVSPIEGVSAIAFHDMHVMCSSVCCFKNYVVVGDVCRGVSMFYYQSRPVKMYLLGVSEAVGVMGVIYVMRIGMLGGVSNRVLGGSSRNMLEGVSNKEYNYKGSSRVGLYDSSKECGYKGVSNKEDNYRGVSNTIDKQHPVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEH4</accession>
    <name>A0A4Q9LEH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2592p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002592">
        <property type="protein sequence ID" value="TBU06358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2592p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="22259" checksum="DD113D9AAEAD071C" modified="2019-07-31" version="1" fragment="single">NILFLLRYSVLDNLCCYNLIVIIEGVIYLNNNFKSEKEKIKFKKLNIISNKGYGSNGYGSSGYDSSGYGYDNGYGSNPYGSNPYISKYIDTNTINTNTINTNTTNNINNVYVQCFVVSVMKREKRLSVKCLKDKVISKVGCSVSKVEEIIGVLVEKGIIENVVGSVSKVEEIIGVLVEKGIIENSSSIGGGECICSIEIVVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LET4</accession>
    <name>A0A4Q9LET4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2582p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002582">
        <property type="protein sequence ID" value="TBU06414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LET4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2582p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="152" mass="18175" checksum="85956D3B3C62A800" modified="2019-07-31" version="1" fragment="single">MKTIIKFKNIKPKLRHLKSKVQLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNTVDHLATRCEKMLGHDYTRRHNEFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEY8</accession>
    <name>A0A4Q9LEY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0594p0010</name>
        <name evidence="1" type="ORF">CWI38_2548p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002548">
        <property type="protein sequence ID" value="TBU06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000594">
        <property type="protein sequence ID" value="TBU12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEY8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LEY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0594p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2548p0020"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11684" checksum="B03FAC318C3921FB" modified="2019-07-31" version="1" fragment="single">MNFSENLIKSYKEAKVFQELSQLNCIDYLYDGTSFGVSTNDTLKIYCPIRGILYNTIHIPQLRKFIFLFKNTILHSTENYIKYLSLYDNQYIRSFKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF30</accession>
    <name>A0A4Q9LF30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2539p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002539">
        <property type="protein sequence ID" value="TBU06608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2539p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="9409" checksum="89D2E554E7D4B270" modified="2019-07-31" version="1">MKHICNGKGVIKGMVRGVRDKDSKEGGVSNSSSYKDNKEGVDKDSKEGGVSNKDSKECISNSIHDYKGVSYIINSNEINGSIIDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGL3</accession>
    <name>A0A4Q9LGL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2432p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002432">
        <property type="protein sequence ID" value="TBU07223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2432p0020"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="123" mass="14374" checksum="9A7B85AD5429E7D6" modified="2019-07-31" version="1" fragment="single">SNEEDFRFAIEQAKSNQNIEDPPLELPKKKKRIPKNNKENNTNSQSNTNKLKETLNNILLNYPQNTEMAENTFQELESLSSAQLKTLNIYNEVYLLSNLTFKTDPLSLKERSKNILERWNTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGL7</accession>
    <name>A0A4Q9LGL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar import and degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2456p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002456">
        <property type="protein sequence ID" value="TBU07087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGL7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2456p0010"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21920" checksum="5BCA94770B61CDE4" modified="2019-07-31" version="1">MGMNYLSGIENGAFYEGEQMTPTGPFKIDMKVELIQLRQGFLCGVFRIYNLTKEHDLLITYFEGEIMGTYTNPFLPALTSEAEDDILHWNKFPEWELNYISEPESYDYEANNFLYIKIKERFLLPDPSIKNIPGASIEGLYYCRYSKQKDFFSGFYFYKNYTSNTSQHLKLQRTKKRTAEYYEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLE1</accession>
    <name>A0A4Q9LLE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2208p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002208">
        <property type="protein sequence ID" value="TBU08897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2208p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13064" checksum="EF8B7CEB76ED4CE4" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESRLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEEKIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNB6</accession>
    <name>A0A4Q9LNB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2148p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002148">
        <property type="protein sequence ID" value="TBU09446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2148p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26906" checksum="4C0A8C6C4E8EE9D3" modified="2019-07-31" version="1" fragment="single">EVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLDVILGAEMHEEPTPPLKEAKRDEDGVKTENKKNNTPHISQGGATLEEPTNNINEESDLEEETLVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP76</accession>
    <name>A0A4Q9LP76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0189p0030</name>
        <name evidence="2" type="ORF">CWI38_1895p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000189">
        <property type="protein sequence ID" value="TBU04060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001895">
        <property type="protein sequence ID" value="TBU10263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0189p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1895p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="455" mass="53788" checksum="CBF34C9D60A8B16A" modified="2019-07-31" version="1">MNFLLIDQNVEFSNNDLSLFSFSDYSATLIKEISKNDDTILHFFYCFFALFDIRKLVFYSSSVEFDKIYSILESIIKNLDEIIFYNQLIQNNMIICFMNNKMFRNIKHIHFIATKFQGERKFLTNIFPNLEIVSIIFLVNRQLEIEIIKNSDINAIIQVLKYKFVKDFDDNIYRLIGAGCIQKNNENSEFYITKNTRLSKLDNLILFKNEIIKIFVCFKNSVTSEILNLFDSFTNLKNIEIHCKPIENCEKFLREFYIFKYINKILLRRYKMEKHIVQGILNLSNLRILIVEHINNEIKDFDFIHNFQDENINILRFLNTLKKLESLIINSTNLSKILSKNEFKNFISNQNFKTLTLSSDECNFFEIPYSLSCRISEDFHFSGKFSSGTTNGLFSGMKITDLKQLSISYCYINQKDSRVLKQLNSLVYLDIDNCNFQNITLMNCFVPEKNTLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPS6</accession>
    <name>A0A4Q9LPS6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_1400p0020</name>
        <name evidence="13" type="ORF">CWI38_2067p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001400">
        <property type="protein sequence ID" value="TBT99279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002067">
        <property type="protein sequence ID" value="TBU10046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPS6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1400p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2067p0010"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="9">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="11">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT99279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="264" mass="29842" checksum="3AF112EF68A533E2" modified="2019-07-31" version="1">MLDKLGGTFAPRPSTGPHSLKECIPLCLLLTKKLQYAENSKEISIILNDKQIKINGRVRTDKKFPVGFMDVLEILKTKESFRLLYNTNKKFLLHRITDEENNIKLCKVVNKATLSGDIPHIYTDDGSTFRYVDPSIKVGDTIKLDLSSRKVIDFISFGIGKTAFITKGKNLGCVGTIFQIDEKEGICDTIHLKDSAGRTFLTQKSNVFVIGDENNVLISLPEEKGVKISEYEKSNLRYGELIERNEGEEEESISEENNEMEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ84</accession>
    <name>A0A4Q9LQ84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PIF1-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1611p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001611">
        <property type="protein sequence ID" value="TBU10683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ84"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1611p0010"/>
    <dbReference type="OrthoDB" id="272985at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="12618" checksum="C73625A9E976FD64" modified="2019-07-31" version="1">MVILEQTNTSRRTRKKNNDQKIDEDWFDVVVRAILADTNNYVNFIDFKVLNLITGEIKTYNSIDTGIDKEEVAYQTEFLNLLDFPGTPLHVLKLKIDVSIILLQNFVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG3</accession>
    <name>A0A4Q9LQG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1754p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001754">
        <property type="protein sequence ID" value="TBU10447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1754p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="120" mass="13982" checksum="6069C27E6964A4A4" modified="2019-07-31" version="1">MKNLETAAILEGNRLLKSANNNSCCEDTELFLKKESNRRGILTLMSFEELVSVNESLRWFKEGSIRPRVEEVLCYIQDRNVFRGKKVSVNTAKRVYNCSLNIYQFKHSKRIRGHSVEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQN3</accession>
    <name>A0A4Q9LQN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="3">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIF6</name>
        <name evidence="4" type="ORF">CWI37_1394p0030</name>
        <name evidence="5" type="ORF">CWI38_1698p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <text evidence="3">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001394">
        <property type="protein sequence ID" value="TBT99298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001698">
        <property type="protein sequence ID" value="TBU10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQN3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1394p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1698p0010"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="241" mass="26770" checksum="3506AA32DA4FC975" modified="2019-07-31" version="1">MSSRIDFEGSNEVGAFARLTNTYCITGRSSNKNFYNEIFDKVNIPVIETTINGIKTVGSQCQGNKNGLLVPITTTDQELYFLRNNLPDTVKVMRVEERLNALGNTLICNDHIALLHPDVDKETEEMINDVLKIDVFRHNIGFEPLVGTFAALNNVGMLVHPHVTDEEMEELANMLEVQVIAGTVNKGSGCIGGGMIVNDWISFCGIQTTNTEFLVIETVFKLSDSDLFDSKKEFFIDGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ6</accession>
    <name>A0A4Q9LQQ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1540p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001540">
        <property type="protein sequence ID" value="TBU10808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1540p0040"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="9859" checksum="1A00CCAA528061F5" modified="2019-07-31" version="1">MQCICNLFIEKIDYKGQELAKKIMMIVYILGYTMSLIAGYTLGDLKYVLYGGIATVILVVLLVVPSWPFYRKNLVVFGDKEKEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR6</accession>
    <name>A0A4Q9LQR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1489p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001489">
        <property type="protein sequence ID" value="TBU10893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1489p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="32582" checksum="7818864C69163319" modified="2019-07-31" version="1" fragment="single">TKTAINILIEVINDFDHDKRLKILEYISEPIFKDVLKNQSELNTIFDFPRNRITSYSDPKVSRFPGVFIELFCQEADVNRINVLYDFLIEKTKQEYHKYISAIICLKAFCLKDGILEQNKAIRIIMEFIFLAKVLKIESEKTVNVKEIQRYRNAYIDAMKKAIGIQNMKYAINTDTGFLDESKVPRSSILLEIFVLVDLFSNDEFKKFLNTEINKKLEGNQNKRPGNSDQVKTDYLIYIFKHENTRPKKNLFFYTTSNVLAVSVLFVGLYFFSARKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR39</accession>
    <name>A0A4Q9LR39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1512p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001512">
        <property type="protein sequence ID" value="TBU10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1512p0020"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="361" mass="40168" checksum="B368CC6B8282D67A" modified="2019-07-31" version="1">MDIVEGVNNSRDIKEGGVSKGSMLEGVSSMDIVEGVNNSRDIKEGGVSYKDIVEGVSSMDVVEGVSYKDIVEGVSKGTSNYKGVINSTNKQHPVNNITDTYHPLNDSTDTYHPVNNTTNNTPSYTWLFTYYDILKDKLKGKEYEIINNKEITSKNKKDYKGFTNKGLDSHDINKGFINKELTSKSNKDTNKDTNKDNKGLINKELTSNYNKDINGFINKELTSNDINNQSCKLSPFSIKVRFYKAIVVEEGVNYSNIDNVCYLLIKEVNSSNKKEWVWVVNKGVIDKVYVSSIKGCYYSVVEGVIVFRSSSDKRGIKGVIVFRSSKGVIVLRSSIVVVVGNKGCYSIIGVVVVISRNSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC6</accession>
    <name>A0A4Q9LRC6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2054p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01002054">
        <property type="protein sequence ID" value="TBU10065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2054p0010"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="247"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="546" mass="65456" checksum="3BB9E5A7A7996D14" modified="2019-07-31" version="1" fragment="single">KTHLRSLISIFLSENISNENSFVEFLLLNMNQINEKHLSLGFYFGLKTILFFVEMMKDKICKIFLPFDNDKENNLDFFVFKERLIDYFIKLSQEYLASIFIELFKDGVVAIEYIFKLYMDVLFKSSRLYFYVRKEVSEQDKFERLRNHLILKYLMAFIFNITYQTFYETINEDNDCIEVEDLDRELSKLYNFKLFENLLQNIFHYTDIETKKLILRNKFNRSEYYFRGINFKVTRSVIFNSTINILSQSNLMEIRYSMWFITFRYESGQGIGLIYDFFTLFGKEVNQNKYFEAFRTLDYYDISNLNNENENFIKKAYYFLGIIMAKCVAMNYVLGLELIDSFYLYSLKDKVTFEDLKYLDYEFYQNINKCNLSDDIDSFGLYFTVNIDNLDNEYELKPNGSNISVTTSNLKEYLHFLFTLDELKLFIEGERAIYIDEWMSSTNYIGDYHKDHHVIVWFWKFVKSSNEEIRKKILYFVTALEKLPIGGFQSQKFILKGFSIESTPCKELFPSSQTCVNLLILPCYDDEETLIKKFMIALENKEYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT4</accession>
    <name>A0A4Q9LRT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1297p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001297">
        <property type="protein sequence ID" value="TBU11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1297p0020"/>
    <dbReference type="OrthoDB" id="2187509at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="23267" checksum="E7884A1E01EB062A" modified="2019-07-31" version="1">MERYSNFRDPFTGINPFLNPKRKSLRFFDYIIAVLKIPLLLFLPFFIDYFIKIKKKSEWKGEKCNVVCNNVSFLDKIILKKIFKNVDFLYYNDDINRKSSKLVKVIFPEECRSNGKALLRMKEVKCDYVCGLRYNDESVFLYGNFLYFILQFLASKNHVEIDIMKSVSSKDLAKATGLLPINMGKKEFDDFLKILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW8</accession>
    <name>A0A4Q9LRW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1440p0020</name>
        <name evidence="2" type="ORF">CWI38_1463p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001463">
        <property type="protein sequence ID" value="TBU10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001440">
        <property type="protein sequence ID" value="TBU10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1440p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1463p0020"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="41142" checksum="151552E0FB36B38A" modified="2019-07-31" version="1">MNESLNKENYLENKKKKFDFIFANKIINKEEIQRLSWGGIPNEYRGILWRLLLETSTLNLNLYKNTLENKRDKYFYEFLQTEKSMEFCVSGFSKINSNEDKKMENLIFNFKNCNFKISGRSKRQIEIDVQRISDEQKIYSKIDLSYIFKNILSLTAQRKPAVGYVQGMADILVPFIHTFATETSPIDLQITESSSYFCFTRFLEEIQENFIDLQPGITKSIEEFKNALEAIDPELFLYLQNINLQSDLFVFRWFNCFFLREFVLKDSLIIFDTLFSYKNINFKQFSIFFGISLLCFFRNEIFGKDFCDTLLFLQNINQKKWKLSEIHVLLSTTYVNQHIYNKQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY8</accession>
    <name>A0A4Q9LRY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1510p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001510">
        <property type="protein sequence ID" value="TBU10856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1510p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21281" checksum="90588EC9E0ADA6F0" modified="2019-07-31" version="1" fragment="single">MNKNFYFSPIKMTDENNFFQKNIPTFTEVSSHFPGMGTLLIKGESLIHHIKNQYSLTYTHLPLLTYKHALKILFENLFQANFTDITVIFFLDETEDIYIECIKEFTKKIIKKNKKLKMHEIFFKDFTDFLSEQRVALTLTDTDISSLNYLKHCLNIDIYTGLMINMEFKVSSVSLFVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS69</accession>
    <name>A0A4Q9LS69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1219p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001219">
        <property type="protein sequence ID" value="TBU11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LS69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1219p0010"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="2">
        <location>
            <begin position="796"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1725"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2123"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2123"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2137"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="2222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2222" mass="248011" checksum="F088DE9602144BCD" modified="2019-07-31" version="1" fragment="single">MDKPIIFSQKLVFFLNHNNHRTSAYTEIHLITPTPTITFNINHLEITNLIITEDNQKYSLQDNKKGRNRYNKDCNKDNKDTYNSNKDTSKDSNNTMLNNSSGNNTLLNDSSGNNTLLNNSSGNNTMLNNSSGNNTLLNDSSGNNTLLNNSSGNNTLLNNSSGNNTPLTNPHINNTLYTLINNKSLTLPINTPLKITIEYEIPINNPAILTHQIDNHIEILGTNTHTSLFPYINTPTSYIITYVIPITPDLTLVSPGVLQGTAVHTINKASDKTKDENKDKRVLDTSSSNKGVLDNSSSNKGVLDNSSSNKGVLDNTANNTTPIHTNTTDNTSFNIYTYKIPFTNPTHISFILGTFEIHDISTNIYLYIPLCLINKIKDSLTEITGDILNIHKITETFTQTTIINNNTPLFNSTNNSINNTPLFNNTNNPTNNTPLFNNTNNTINNTPLFNNPTNPTNNTTFSYIPFKKLSLIFPMSFITPFVSHESIYINTSYLPISTSSYNTSNDINNKHIPNTLTLPPIEHLYSLKYKLSKMYSILILQHPYNIQDSFIYKGLQGYIKDNILRIILGNTSYIYNIYKYKEYVISKDIKEYPLYSVKRNNYSSSFFLTKSTLFFHVLENNLSRAFMQRIVNRIIMFNNTWVISGVMVGGVSNRDNVLEGVSNRLEGVSNKDMLEGVSNSSKDMLEGVSDKDMLEGVSNSNNGYKGVSNSNKGYKGVSNSSYEQHPSNYSTNEQHPSNYSTNEQQSVSNNNNNHTNNNYISFSNTSATLSDFYKILKDVCGKDCRSLIDTYVLHSGILKITIFMRINTKKNKIDLCIKQKSTSTLSTSINKTENTTTTIRCYETEGVFDHIIPLSGTFSFYYHTRTKKSVDKSTDLSVLWIRIDPDMLYLHDFTLLQPDYMFVEQLLSDRSVFGQMDALKGLKYNVSELTVNALERVLNNIHFYYKIRVECMYILTHCNVGGGEGVSDKGYDYKGVNYKGYDYRGVDDKGLESDTNDYKGVGDKEYDYKGVNNSTNDYRGVNNSTNDYKGVNNSTNDFRGDNYTIDEQHPLNHTPNEQKGVNEEYTDKIYNTYDTNTYNNDSPYTNTYNSTNTNNPYTNPYSTNPYTNPYTNPYSTNTNNHHNPYTNPYTNTNNHHNPYTNTYGTNTNNHHNPYTNILTTNLNNTYNNNISINNNNTTNYPLDISSCSSYDNYNTITPFSSGYMRLLQFFIRKYCYLSSTIVKSNDYNSFTSYFIEKEIIRSISVSNPYILRSKNINSEITLSFIINLLKYNDNSSNGYSDSYYIGSLVECIGLPLCSMGKGYVSDKGVEGSGVEGNEGVRYNGLEGVSNSGLEDNGLEGVNNSRVVLEGVSNSIDKQQGVSKSGCELEGVSNSSNDYKGVSNSTNQQQGVSNSTYEQQGVSNNTNNYHPSNYTTNEQKGVNTNTNNYHPSNYTTNKQQGVSMSTNNYHPLNTTTNNNNNNNNNYLLQALQIIERIRRMDLLFPSTCNILTCVSLLLYGRLHKYKLIDLELEGVISYLSSDNYIGVRLIAIEVLLCIGMSNSKVRGVIYNMIENEERGVRMYIIKGLYYYIRSIENKGGDSKSMLEDIKGVNNSKSMLEDIEGVNDTKGMLYDIKGVNNSKGMLYGIEGVNDTKGMLYDIKGVNNCKGISEDIKGVNDTKGMLEDIKGVNDTKGMLYDIKGVNNTLVVEGGVNDRGYVGGVNDIGYVGGVSNIGNIQEGVKNRGRIEEGVNNSTSGTINNTTNTTNTTNTTNTPSHNNTPSHNFNTSDPLSSLPSLRHYLSNLSITYYYDREFIELIEMCLETPEKEKENMKIKLIIKREIGCYLYKIKRITEYKYNRYISRNSRVKGVIDKLVGVKGIGGVSDKGSIIRGVSDKLVGVKGIGGVSDKGSIIRGVSDKLVGVKGIGGVSDKGSIIRGVSDKLVGVKGIGGVSDKGSIIRGVSDKLVGVKGIGGVSDKGSIIKGVTDKGSKLEGVSNSTYKQQGVTDSTYKQQGVSNIIDYFNPVSNIIDNYNPVSTSIDNYHPVSTSIDIYNPVSTSIDNYNPFSTTTSNIKGILGVNISTFNNTTTINNTINNIPNKKIRIKVINQPLGVIKLSLKQSFNDPFIIQYNSIINNSLYSTKVEGDNKGDNKGDNRGDSTNTSSITNNTNNISTNNTNHTNTNTTNTTNTTNTTIIMLSILNRLISHKGFNQVESFIEEHKSNFFTFKVLTLKEIKRKVINNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN5</accession>
    <name>A0A4Q9LSN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1679p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001679">
        <property type="protein sequence ID" value="TBU10565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1679p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="41560" checksum="A5C29C3F1D718974" modified="2019-07-31" version="1">MQLSLVTFKISKQFHPFFLFYSLLGTLLLFLPLTPFISFLIVNTLLLVSTLIDNTPLLYLTYGYTLSLTYLTVTNLSITTLRKENINLLTRIETITILMSLILPYNNKTIFIVYIFIQFLNIKNLTFPPVISYHNTVAIERLYITLCMLYGRNSYNLITEEYKTVLDFYYNRKQEIPFNVTLSFFYLLTPLLLINTSSIVKYAVTFNILVNLQLFELASYCCYLMCILRCYLFAALFGLLGRVSGLFYVYENNVVINNKRSSREVVKDCSDIIKNCQKTSIDKSEINKIQTNNEYLSNKIQTKNKYILNKIQTNNEYLSNKIQTKNKYILNKIQGSNEYILNVNIPTRNKLMSSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC3</accession>
    <name>A0A4Q9LTC3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1007p0040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001007">
        <property type="protein sequence ID" value="TBU11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1007p0040"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30077" checksum="B6C22CCAB017D8FE" modified="2019-07-31" version="1" fragment="single">GEGSDAASKLKDISVSHDEFQSIYLQCLEIIKNLYRKAKLIHADLSEYNLLYYQKKVYTIDVGQSVDIYHENGISFLIMDIKNINAFFSKKGCEVKEINDFFEEVTGFILPECLSDIEINHKCFVPTCLNDVFNTEDCKNFTSQSFDTKIANIKSQEKNLEFSTENTQAESITMEKDKINKIKTTYLDINIDSENITIEEECKNETKLSRKEKWMLIKQKRKQVKEEKRIRRIEKTKKTSKKCKPKHKNNKIKILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG9</accession>
    <name>A0A4Q9LTG9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1515p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001515">
        <property type="protein sequence ID" value="TBU10850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1515p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="364" mass="43324" checksum="B1F78E8451AC56BF" modified="2019-07-31" version="1" fragment="single">KETPITKFDFNDLKYQIDSYYWITFTIMFITFDIFIFNYKNLGFLNIYIENVSMDGLFFTNTLIVQNIRKIFMVKSTVGPNFLKDILLLPKLKDINFINCKFNFTEIRSKFCRNNSIKLCKIKNSVSNNDQEILNFIKKLNNVEEISLKNNENIKWFDENFVSKKNQFENLFSLIHMNSNSTEFLPNICLLKSIRILSIGKKYKEGSLSKIFNENVLLKISELRFKEFEIGSKDKLALRNFIGLKLLHIHSCKFKSCLFSDIFDQKKEYFIEKLFLKKLVLRILDIFFISKLKYLMNLQIDVMHIEDTNILLFTMSRFLFHNSLNINILTASNSKSILNLLKEEFSKENISIYFFYNLDEWFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ3</accession>
    <name>A0A4Q9LTJ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSD13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0980p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000980">
        <property type="protein sequence ID" value="TBU11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0980p0020"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSD13 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="349" mass="41233" checksum="4BE31636F7FBB9DF" modified="2019-07-31" version="1">MNQIETYFSQKKWYNLALSIEENLEKNKLVKEILLFIENKIFPVSKSFYPTTFASVVLSTIKHRDSIDLIEKAQELLRNDLLETETHFLAVDFLEIYRLEFMLLNGDKCHTQVYNFLEKKLKDAHNKKMIANLYRLSYEFYEIIGKYEEAYSYLIKYVEICGMPDYNERNYNISDISPKFLAEKMARLSLLSKDIHNYNTFYTSPIFPYLENKELSDLYINTKQANISFLKKTNLITKYGLSIDGLIEKAHLISLLNYFFTLKSHRVRFDEAAKLLNIPKNNVSSIFLKSLSMKIVKGYIDCEKEEMVFTLLMCKILETKDIDDMINKFDSWRSKVRNVINTMDFGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR8</accession>
    <name>A0A4Q9LTR8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0934p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000934">
        <property type="protein sequence ID" value="TBU12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0934p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF35">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="97190" checksum="CDFFCA3B99C738B0" modified="2019-07-31" version="1" fragment="single">MNYKNWLVLPDTSSNTKKTNKMNIKYFTSINFSKIIRKVSFLPFIILLFNIGNCIRITISFTNEKHSKELPSLQPSSIYPKKRKHNPEISVNRKGQILSNYKNKYMEQIKNNKYLNTPPSNNLKKSIDNIKEGKGIIIKNSSGDGNHASLSTSQFIPWSEIIADDSNLTNSEDNTEVSSEEHIDSITFDYSSDFIIRSKYLDCLNETNIEELHLNIKDITECKIDGVLCEMLLFILPSGLDFGFPNLNNENFLEFIWFLNDISCYSKYDALETFYKNLLPFLYSYVTYINRNMPEESREIFSIHKKQLFPFIAVLYDTIDLSFDENTNELTLQKKKENRKTILFIQNISHMFKFRTDPETLNIVQQDDYATQRNILTLIFNSYEIYRIKISVDDKYWAEGTNPVIESNASEKCLTISEIKNGFSSIFFSMNLNQKRSIKSVELERIVLTIKDMEFLNDLKVLETLVIVHCNLDCCIDFLWLLPSSFPKLKILGIIGYTLKNNFFENINLMNIRILNLSKCEYNDNPNNLVVKKNKYLNSLKMNSSCLNQKVFKSMICSDLLIDLSLRAVDFTEIKVDKDCFDRKKTFQFLDLSECKFNDEFLDYFLTDLKAKKLNLEYFPDFQHLIKILDQESLHLSTEFLSLSGNSLYVDLYISVSRFKVLKRLKLSHMNYMICNDFHPKFAFKHQLNAIDLSKNRLNKDSMIFLHQFNNLKELNLSNCNLETGYMEILFTEHLSNSLVELNISGNSFVASDFFKIVYLKNLIRLTVSFDNQVFLNLEDKYDIWKFKKLRTLILVQTNIEDLLYKSVITIKDIKIIEFQNCKFEDDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT1</accession>
    <name>A0A4Q9LTT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0926p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000926">
        <property type="protein sequence ID" value="TBU12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0926p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="6801" checksum="17D4A05073474DC1" modified="2019-07-31" version="1">MDINQRGVSDKELVIGVVSQKGVNYKNIYCKQRGVNDKELVFVVKVVLLLKLTVLKNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU12</accession>
    <name>A0A4Q9LU12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1389p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001389">
        <property type="protein sequence ID" value="TBU11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU12"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1389p0020"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="528" mass="60958" checksum="B3FAFD8E78B3169C" modified="2019-07-31" version="1">MNQNRCLILYGITADSLTSALQMIEDVSKGKVIFKETCSIYENGVLMTYLCDNMDMAGICKILCSKGIKVMEYEKYGRFKDFSKNKYEDLIAISENELFKWQRDLKNEMFVLRNNEKIVLYENCRGENIKIIFECEAWQVKFSEDGKFMVVNKGNSILLLGGESYGIFCEIPVKGVLLGFGCQGRFCVIRDAEFVYFYDVTVMKELYRFEHEGSEVIWTEDMRYLKFLNFQETFSIKDCNIMQIDNICGINCEIIEKVSFKNDMTAIITNEKIKNVIFCVQDNIISKKNYVNFENSNIFWSENGVFVEIVRKLDNKTVVSLEIFKKDGTVLIVPLDCSISDLIAGDNSFFIFDTEKKLKFYQKKISTFTLLSSVSLSNKVILSKSSAADIFAIYDYASDSVEFYEDGKVISTAAHTSCTQIKWSHSGIYCSTISSGAQLGGLVQVFDIDGKLIWKKVFNRLQDFHWRPFIQFTDKEYLECNFEKLTSEIKNLNDEIQEESENIPKKQLISEWVGFLQRKKALFLNLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU62</accession>
    <name>A0A4Q9LU62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1061p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001061">
        <property type="protein sequence ID" value="TBU11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1061p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="31235" checksum="42B4B6DB2210603A" modified="2019-07-31" version="1">MTPHHDKINIFTSIKQPIALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLYSKLCSARKNEHVSVSDSSRWLKKGNIRLRDEAVMCQHCGKSCITADHLATRCKKMLVVRCLHLLLLNRYNSHSVQEILDNEYAEIRKLKKYDLLANELGLIYKCSVEIIPYVMTRDGIVTKYHKSHLKRLEIPMNIEAYIQSIVLKKTSGLNAEESWEKASMCEDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU95</accession>
    <name>A0A4Q9LU95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0846p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000846">
        <property type="protein sequence ID" value="TBU12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0846p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="564" mass="67572" checksum="577AC3D36BB3C94A" modified="2019-07-31" version="1">MINFLFALISSSDTDIPSYNEMRIPQVLYTSNRGNHYEYFTNEIMNKDTSCVPYRCNPQRSIRFGSNYCNATNEETLISTYESTSCASVPNVNHQDLNMANITTLALPIFEILELSAKTKTLISHFIQEKKNDQETSYIIRELIYTIFLLENFYSDSNRNLSINTSAISTSNFKHGLFYFQIYSEQYRFVESTTIIFDFHHLISNLIDEVRYLNSFHYNEEMISNISKYIESIENKEAEYIAMFPRNYDGFRNVWLTEIENILTDNDASILMQLFPEFNGLKAYILKNQNTVPNRNNYHVSSLLLLKYLFTNKYILNIKNEFLAYKKNLDYNKYWLFKYLCDKKIIFEILHLFIRKTVSNLNAINISLIIYSTERIILFKNRKRMIYDVLNNINFIRSVIFLVDDNIIKDFHKIYYLILNNVLFYNNNCIRERTDYKMFEIEKLFNNENLLKILEYHLEIFYSNHSIFKKKYELSKSKYRYAFRMYKNLDNFDLIKQKIIKKNILFQFDLKDGNYIFGVFKMILMVKSINDRLCSFISGDFQIYSLRNEMNRLKSYKLFVNKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA3</accession>
    <name>A0A4Q9LUA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0846p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000846">
        <property type="protein sequence ID" value="TBU12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0846p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="23503" checksum="87DB0E459BE792AE" modified="2019-07-31" version="1">MSWDRIVTEYHKMYVKRLEIPMNVEAYIQSIVHKKTVDTISFSQEEHWTFRLNAEESWGKAPIMHEEPTPPLKEAKRNEDGAKSDLEEETKVVKESLVQEILENECAEIRGGIQNNRHEIFILDKNDRLANKLGLIYKCSIKIIPYCANTYGIKGMRSVDRLKKTVKKISKSVLMSSIKSGQKQEETIHSLKQAINEEDNVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB4</accession>
    <name>A0A4Q9LUB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1712p0010</name>
        <name evidence="3" type="ORF">CWI38_1035p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001712">
        <property type="protein sequence ID" value="TBT98535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001035">
        <property type="protein sequence ID" value="TBU11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1712p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1035p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="171" mass="19806" checksum="4AC948371DC2E776" modified="2019-07-31" version="1">MRMENICTKSNKKTMHSAHLLFEKKKKEKFYYVAACKKMNKIIEEQENEIEVEDEDVNKTAEEIIKKRKKTEYKGFLRMPTEEEICQDIEEIHGNKDLIKIFEGVLTIGENEFIKGEKIKINLHGNVFSASIVQIGNTEISIKAKDGTRTKIQLVGLKGKGIKIYKIKQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK9</accession>
    <name>A0A4Q9LUK9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1199p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001199">
        <property type="protein sequence ID" value="TBU11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1199p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19328" checksum="AC9411962FF7C6AA" modified="2019-07-31" version="1">MNFSYYIYSYIFVFVCFYFDTKNIETKYFGYCGSRLHCDHTYAKSFTKATNEREVGSFPQEMEENEEEDGSFPQEKRKNQGGNNLICFTCTKSVGSLIRKQQLPSKTGESSGNKQKDTDDSKKDILYARIISLKKNRVLNPKVRLDRIKGLETRQNTSEKTEDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ5</accession>
    <name>A0A4Q9LUQ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0776p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000776">
        <property type="protein sequence ID" value="TBU12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0776p0020"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020518057" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="35878" checksum="03E12F0BE1DB647F" modified="2019-07-31" version="1">MLSLILSILLLINIIQAECVGQAIISYDEGPTDKIVKILEISENLNVPIVFHFCTDSLKKNLDVFKNIKDKNVEIGISITDDLYALDIDLIKEIIISRKKEFEELTGYTPILLRLPRSFHPSESKQIAEDLGFIVTDPLIDSEDVETPNYICLVKNEILQLDKNIENFSIVFRERIDTSVSELENFIEMLKDKEFTLTKYSTLLNRNTDLIPIIKKNEEDIEEEEFKDEGSKKAKNNLEKSEKNKNGDDKVKTDESDDFDPVFPNPGTNVDSESNIEESDSLVQAMDSNNEKNSCYGMNYINGFLFLLISLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX6</accession>
    <name>A0A4Q9LUX6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1226p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001226">
        <property type="protein sequence ID" value="TBU11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1226p0010"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="54583" checksum="2A3DD3A237A0119B" modified="2019-07-31" version="1" fragment="single">MSETLPYYCHECGTTVQIDDNFECIECGGRFVEIYDENEHTDYNMYIDSFESIRQLTDELHEVPQPGSNFFAAFEERLRSLLNNRRGSSSSIASDRRNYAIGPELDNIIAFLLETEGRNTSLQPANEDFIKKIQILQSKSNGECSICLNRYNEKDWGVYFKCGHFFHQECAFGWMKVHNTCPNFILSDSKSTPLSGSDFVQLEVEKRVLLMETSWEQLEQALLNIALNKDKNIERGILQGDSLSPFLFVLYMDLLSRKLNEKYTKVTVQTDVESHSTNPLLFIDNLKLLAKDNEEKEFLKVIGLEINIEKSATNDTCCEDTATLLEGVSVYKYLRIIEDSRGIPTRSSFKEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGIGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV69</accession>
    <name>A0A4Q9LV69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1085p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001085">
        <property type="protein sequence ID" value="TBU11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1085p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="50611" checksum="F43DFAF9B5B1D583" modified="2019-07-31" version="1">MYFTKCISNDNFILMTFLFILCSNASILIKENGKNSEIKTIPETQESKHDTIKPGKLDDSSDSVSTYLNINISKNQQRRNSTNFFRLRKLPNMNFSLYNGKEEQDTETEPMQTIKIPGMHFQEGNFSSLPDSISPPSIDIPKCSMEEVANNIINYSEKSKLPEILILLEDGYLIKNHISTLGTKKYFLILKNLIKIENKILELNAEKKQDFEDHFQKNIENSDLSAPQGSILLQLPVFIAIKKAIEERINLAKSDIKNYVTVFFGLQGIERYIKYTDKEVKKILNAPTATDSCNTSDVLPKYLELFSDAKTLIGEKSESVSSGAINNISDKISPVLLAVMFYFDEEEITEIYTLYGSFNTSSSSDSKFLNKKEQEKTIFSNHLIFKIIKYYFDIFDTLYMKKPFKFSSFASNQTKYESLKKRFDRLSKDEAYFKKNILIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV72</accession>
    <name>A0A4Q9LV72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0821p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000821">
        <property type="protein sequence ID" value="TBU12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0821p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020194846" evidence="2">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16753" checksum="D8C13E1270B90E28" modified="2019-07-31" version="1" fragment="single">MNNIFLWFAAIFGSGSSINREVGSEINQLPNEESEKRTNKEDSLKSESSEMLSTENSTGGARVNYKKSNNLFSSEPFCHELNEGFSRLKTSEEKYINPNRNFSFPSQNHYSETSCHESNAQFTCPKSSPNHFRYDTDTKSLFDSSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD9</accession>
    <name>A0A4Q9LVD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1050p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001050">
        <property type="protein sequence ID" value="TBU11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1050p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020331262" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18042" checksum="6CCFAE8A67EB602E" modified="2019-07-31" version="1">MEHSFMFIFLLKCIKLAAFESEDEYLNQLLREFGNLLKDASFCVPIFIFNKEDADFLNEKPSYAVESKENDSQNLLLKTLIEILTKSDLNIFPEKGTSNLQKNILLDFIIEYINKIDEMFSESGCDIVFVKHTIGSEASEINMKSLSGEFEKKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM5</accession>
    <name>A0A4Q9LVM5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1074p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001074">
        <property type="protein sequence ID" value="TBU11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1074p0020"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="5">
        <location>
            <begin position="78"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="484" mass="56509" checksum="A4D0358BA53ED22D" modified="2019-07-31" version="1">MKKIFEEKPFLQIKATNKTFLIEFPKNLIDTFNQAIDDEWIQITGIFILEKYKITITNDSKIEYTKYQIKKYSNPTDYVALNKMEMNKYCNVIGIVVGYLEPKQSKGSDWVSTIIITDESMETNKIFVKIFSKTPLFPFGFNNGDIIKIKNIKLIKPNIAITGKQNEVKLIYNFFTNNLYTENIYEENRITCLRNIYLENNQKYVRQLKICDLKETCYFDFCGLLINRQIEKNNLVILTLIDYTVNCNIKNVICDEEFANNMILYVKAWDKHAEMAKSLEINEIYLFKNLRLSDKDFILIAHMSELRKCTILNVDNGHVLRQSIYQEQEIYKESFLTSILSNDEIPYGLSSLQTVPIYNIKISGLHRIKATVKFHFPFGILCLYFCRACKLTDINKNSIEEHVFQNSNCNIDKINICRFILKDTSGSCVALCRGKILEYFFRDENFSIHSTKPLDILIMSVSSDEGFKHHILDAIFDIKNSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS2</accession>
    <name>A0A4Q9LVS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0620p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000620">
        <property type="protein sequence ID" value="TBU12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0620p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="50827" checksum="2862E1F024E39DC6" modified="2019-07-31" version="1">MNQIIQFIFLTNRYVALKGNNKDYIDNLRIEICRFLDLYVESVKNQLLESLLYDLHVMIIDEKNRTEQTCSEILKCIPKNSLDFNFVILSYGLNPFVSNFLVFSLHKNETHLLINFISNEKISTAFKENLLLLNPRTTYLFILRFIFFFEKCFKFLNRISTKYDRVFIIQPKQSEYYEKNTLIEILRKHESYFSLKLVIMIEKRFTNIIKNRIACLEDSIIENIQQYVICALEYEFILELIERAKQKIQSISFLYSDLYSVFKRDLNENSKSNVSSKNILNKLNYLKNESVKFRINKYIIIKNHKISTGLQKVKEFVFYCIFITRRYKIDDKIIQAYSLDLFLYTLEIKRSLQFSNLTLNNKIKYDLRIIIKKQINFDPDILMFKIINICDLTRDFYDVKKVLLNLTATSPSEFKEIIKTITNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW05</accession>
    <name>A0A4Q9LW05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0711p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000711">
        <property type="protein sequence ID" value="TBU12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0711p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15652" checksum="3884FEF97B5966EC" modified="2019-07-31" version="1">MQDTRTIENLKEILSRYNDSLIEEKKELFTPKKILKEINDSRKKMKEVIKKEPLNIKKVLEESLNKIKVIKNEKDAISFKEIDDSLVVLSLIRKEIEELQNRSEFLKNIVKYFFVFGITLLSVYIGYSYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF7</accession>
    <name>A0A4Q9LWF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0928p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000928">
        <property type="protein sequence ID" value="TBU12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0928p0030"/>
    <dbReference type="OrthoDB" id="2189981at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="301" mass="34373" checksum="236BD3B786808DF4" modified="2019-07-31" version="1">MGKTEILKFISGQVLSLILSVAALSASFLNTNTNFIPFYALSMAYIVIHIGGHVLYLFQPANGFFKINIFYYVVAGMTDFFGGYFQLRAYKELSSYIVVMLSQMNTPITMILESFVFKTSEFDYILFIEFFALVIAILCINYFTSVIPIKISLLGIFYILLSDLCCVTNGFIQAKIIPEVGIGNYLKGFTLFGFLTGFMMTGYFYRDYVFNIRWSLNFYSKNYVYLFLYTISLSTFYLSASKYINSFGLVAFTASLISVSLYFGNFERLIQKEYNLLPILGSLVCIIFNAYIVYSTKNPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN3</accession>
    <name>A0A4Q9LWN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fam-c protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0060p0030</name>
        <name evidence="3" type="ORF">CWI38_0915p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000060">
        <property type="protein sequence ID" value="TBU05008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000915">
        <property type="protein sequence ID" value="TBU12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0060p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0915p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120563" description="Fam-c protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12604" checksum="109347B51E43EF5E" modified="2019-07-31" version="1">MKLFFGFLIFFNFLVDNIFCAISKNDDNDALLAKTSSYVSIDEEREDITDSKKYLGNKDTESEDEQAGCFGCCWSKKKKPSKTKNEYKESDQGSFQTYRRAASFDDIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX39</accession>
    <name>A0A4Q9LX39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0462p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000462">
        <property type="protein sequence ID" value="TBU13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0462p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="225" mass="26407" checksum="978B75D1893E068C" modified="2019-07-31" version="1">MCNNTPLGVVMYIYNEEGVIYDLKDDSNLTPIGSCFIYLHCGIVEILFLADVLKIEFENENKNASAINTHKAKFIGFIKEYLDEQHIEYDKNLALNNLNHCLLPRTSSILKTFIFVNLFAKYILECNYIRQFVKYCNENKQKFKNSLFYAEDNIFFYVFLQEFSRLSPEERKNIFIIPVTKAPTSDNKNESKEFGIKDFLLFVLIPIVFIGGVLLGVYWYIYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX78</accession>
    <name>A0A4Q9LX78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0449p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000449">
        <property type="protein sequence ID" value="TBU13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0449p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="40455" checksum="B23599C62464B7B0" modified="2019-07-31" version="1" fragment="single">MMYFYKLKIYKIFVSLLEYLIILFNIFPKCHCNEIYESSFIISENRICFYNFQVIFNEKKYTYGVRCIFDTRNEPENIRNLSFICIYNDRNYINFDYLDALIVDNILNMNISGKFLSKFNLIYYLKITQTNDSFIENLNLKDLYNLLLVLDELKAKQNKNLKHFTLAVVFRLIYGNDFRSNLLLFRNKLKKICCINFYIANQVLIGFFKFFFVNISLFEGNFVASFSKYENFKFKPKNFLPENIYFAIIGNEIIIKVERILSDKICFIFFQFLSIKMDINHLVLKNIDLGDDNISRTKFKIFKIESFIIIKIWNVSGYSSHFFSKLNTAINSRIKFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB6</accession>
    <name>A0A4Q9LXB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0796p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000796">
        <property type="protein sequence ID" value="TBU12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0796p0010"/>
    <dbReference type="OrthoDB" id="2191863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="509" mass="60042" checksum="EEC6A3BC8F915FD3" modified="2019-07-31" version="1">MFIDKMLLGKNVPEYAEEAVYPSTTFRRLRCTKKHCSDVCVYNKDMRSKNNEWEFWAFLLSEKKMDGCYVLKQIGEINDELRFSVWIKLSGARYIKSEFDFSYIIGTENDTVSSEAKKCSTQKNTDSILKIDQMAVKNILASNKISKNDNEREVFCIYKNISKYIEITDKNDLNYLLRFIAYIFDHSHSTQNNSFYFIYILLEKYNMKYIFLPAKYTFDELKKNIKKDYDFIYENGLNFIREFVLKCISENKNIFDKILDLSVCLKENGLFEIIQWIIDQSGISLKEIKTNETKNDNKEIQKSSSESTNVKNIKIDSKITEKKDSSKENNDKSNVKTQDTNENTTKKNNLETNNQKQNISDIIKQNVKELIEFVTKDLFTLFQKLQTHLISIKEINDNFEIISPKDTKEETYFDFLVIQEQCLKAQEAMKTEMEDKIINLTTENKSLNNKNTNLTERINNMEHEISYYQNNIVTDIKKRLQESRKKIDDLEEENLNLKAELVKVKKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC1</accession>
    <name>A0A4Q9LXC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0436p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000436">
        <property type="protein sequence ID" value="TBU13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0436p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020920517" evidence="1">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="22854" checksum="FFCDCB89C991DBE3" modified="2019-07-31" version="1">MIFTSNLFFCILCVFSLKSIKELENKNVIISMYDDPQIKLRINDSLVRFKQTKRVSDEDIAVFRSIDTENYKILFGTIGLCSDSDTYQVIGCTLPKDTSNGWRVVSLTNGFQIKNENNFCLSKDIKTSNLLESIPTWKVYVFPCSENNENQRFQINEEANRNTDSTKSLSLKKNQNISTKIVIPSHDCKSSFSPVILYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ6</accession>
    <name>A0A4Q9LXJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sporulation protein Rmd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0760p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000760">
        <property type="protein sequence ID" value="TBU12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0760p0020"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="114"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27531" checksum="E26399FAB46E5EAA" modified="2019-07-31" version="1" fragment="single">MDDHKQFRQKISLHNTTQDIPVGKKQARIELRAMKDALPLNILPETQSKESVKIEADLKRVTAYCTAERINLKDLYKNINQNEIFNKATMYFGECLYASIRLPISPNEEQSFDIFYYDYGVVVCWGLQQNNETVVLNHLKKFEENKYEVGKVEVESFRYGIVRENPMVLNDIIYLNTEDFFNKMVISNAIAQSVKLDYFENLVDMTVDTVKDLPEEVENEGKVGKTRKDILKLVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXM9</accession>
    <name>A0A4Q9LXM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0520p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000520">
        <property type="protein sequence ID" value="TBU13136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXM9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0520p0050"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="128"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="42268" checksum="780CAA2FA9FEDFC2" modified="2019-07-31" version="1">MEILVVETTCNNLKQKSVSKKLIGKKVFLESKLTKDIRICELYQKNILKSCGEYEINAETKIILHKYSINNEESFNDYFKKCKIPNMEFEKIWNQIFLENEIKFKILSYYTSMLKLIEKKIDLSHFCLNKAILIYGPPGTGKTSLAKSIANKISIRDKNSFHFLEIDCSSIFSKFYGEGPKILDKIFIEVNELSIKNKVILLIDEIESLMVSRNITMSKNEPLDSIRNVNTFLVCLDKLKANKNVFCIFTTNHIKFLDEAFLDRQDVCIEIGFPNLKNVYEILKNIFEILMKKNLVEYHQILGFQTVINLNEFINEEHKLLYDLTKKMTGKSGRCIRKKTFEAILHNDNNFKSILTYLINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY31</accession>
    <name>A0A4Q9LY31_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0615p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000615">
        <property type="protein sequence ID" value="TBU12821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY31"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0615p0010"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="84"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="272"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="48287" checksum="2E2EC9D765804224" modified="2019-07-31" version="1">MNNEVNFQTEKQVAFELFEELSKDTEIIKSSIQASLNNWEIKLPKNQNLIVKEKFSEMELDDYLLDSIYEMGCEHPSIIQAASIPTILKGDDLVVQSKSGTGKTLAYGTCLLQKCVSKGGLQAVILTPTRILNQQISDVIAKLGAPNNINVYTVKPDVKYMNQEIIVGSPGGVLKLFNMDKENAQTVKIIVIDEADAVLNLDSSMGSNAYVILKILEKSQKIYFSATFYPQIKKVIADYSPKAICMYEKENLKPEKIKLYYLETERKEKMKALKSLYEYLSVGQSIIFVATKHMVEVLKKKLEADLHETACLHGDIEMAANEKIVEDFKTAKARVLISTDIFSRGMDIPQVNLVINFDLPIVKGIPNLETYIHRIGRSGRFGRPGFVVDLVSDSNDLKALVKFQTELKSLSKKFSIKALEEVYEENMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY93</accession>
    <name>A0A4Q9LY93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0328p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000328">
        <property type="protein sequence ID" value="TBU14295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0328p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="33424" checksum="52462B04DA2D3881" modified="2019-07-31" version="1">MVSFIKAKAITNNYWNIVIDILECSLYTYEEFNSYSEEIDRLILKNLNKKIGVDQSFETNASTQCFFREDLYFKLTNYKNLLVHKSERYKDYLYILSRIHLKLFIPTKSENEIAEVYQNIENNICKLIVNHVSYNAVLFNKNVEIIDINREDSKINLDKFNQNSKLHIPSFVIRQLFLNDSILASGYHIKVKYLNGTIDSVPTISLEDSNNKEYKYILIKMTNYFDLKIKIENLPWEFNNNDEFVNEFKNKEFNLIFMFKTNNIIEVSDVDWLRMNKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYA2</accession>
    <name>A0A4Q9LYA2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0325p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000325">
        <property type="protein sequence ID" value="TBU14446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0325p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="92223" checksum="7D9CEF010756A382" modified="2019-07-31" version="1">MVVGAFLEAKNLDLFWYCRILSIIVTIYSIMARRTIAIHFYEDIENILASNDSTEYIYCDACLDFFEVKYKPCSPDLEKRILKTFKLDIDNFLLKFMNEEKIEGGKQYNVYINNSLLKFDDLAYFYNIVLSIPCFMDCMDGSKYLLICKVMNIFKYINNKFFKDFIRSILVSMVFNQIETKNWNLSSPNSTEFCFPRYITDIFILELFKMYRVSEKTQNKFGEDLHEMIFDEYFTLYYINLREDFLFIDDDIIREILKLHKKLKNFLKIIDIVFRFHTFKSIFLYRISYIKEYDNIFDVSLFKSSEEINIIRCSNTNSLIERICRISRKKQIETLNIVHSTFNIEEEIAFLKKLCFRRLNYVILKDRYSSSFTNADSDSPVQFIFSRFINQIYDNDNKSNICVRKTRVCCYETEKELTLNFKHHQRKIVTFQKLEFPFLTFVFMKLVNKYISFVFYLINFKEFNNIEMIFTDTSLKDFSLRETEILNNITRIKIVSSTLNDIFLSKILLFPALRILFLSKCSIFKSKDEIKFEENTKIEKLHFGNSLVDDPEIFAGFLSKIVTLNTLEIFCLFGDTNIFLLKSIEKIVNLSKLKRLELSDTYHADRGIPFFPMFSNILYFDFYFNCPKDTFYKLFNSVNFRTLKFLNLDGVILGVNDKLALEKNTNLLRLKLSKNCKISGLAFSELFNLQNIYSLTEIRLPEIQFDMCDFLFFSKLKSLRKLYILSFTLKFDIIYFVKMFNQVKEIVVEYKIPLKDKFLEEFGSRLKGFALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ2</accession>
    <name>A0A4Q9LYJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0301p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000301">
        <property type="protein sequence ID" value="TBU15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0301p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="498" mass="59112" checksum="25DE52F88D4C3B45" modified="2019-07-31" version="1" fragment="single">MNISFGMFTYRMNKKVLNIEVIFSWINILSTFIFFNSVDSYSFTYVFRRNGHSQILFFEKQQIEVLICQESNNDFEVTYLTQHHDNFFGELKLMFIYDKENFVKFEILNDFLSQNPLKNEYVYGIIKCNFELSYYLKISKDITEITEYLNFFQFDEMLTCLSLLKATKNKDYDEFIRALIYKNLISKNIDTIFKQESLARIDVSMKKDNFISAVLDFFMIKYDFYDGNLILLDKKKDIYDVKNFDKHIPYKNLFFNSFKIFCRLEIILGNFYASNLFIILLNELNIKSLIISNKDNYKILDKQFNFHILSTKIFKSIVIINFKDISSLLFLSKLNLAIPNNIEFLSFRNLVVPVNILNSFLESRKLIGLVLNEMKFTGAFPFIKDFYDSNETLEYINICYADINSTCWNNFFSRTNVRKIILSFSSSSAEACFLKEFYASAPYKSVRYIEVRFHRASVISKKILEFLKHFTILELLKLHGYIIEKNAEFHIPNAIECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ5</accession>
    <name>A0A4Q9LYQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0278p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000278">
        <property type="protein sequence ID" value="TBU17630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0278p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="479" mass="55804" checksum="AB82297E9D8946CC" modified="2019-07-31" version="1">MDLLNDDTMEIICREDRKDILIETISKLPATYVEKSPEIQDNGKIDTEKLFERLKKIIERKSNTNKKLLKFAVELTTTKRSKLLECLRSANIAATEIIHILTMIKKIGFLNVGGLSGLKINRINEILQKENLDIIGIAETWKDSVTYLHKDYHVIHMKPSIPVTNRPSNKEGMMIIGKNGLKVKLINGVTEMELTIKIDKYVFIFINRNHFSKIPNVLLPGLGTHTNNKIIQKPALEQDILNSHIENNHILHNEKTSTPEKIFSNCQIQIDTEYIANINHKILLLTLPIIEDIKRPKYKINLLKDTIIADNISKRIERKTFKAKPLLDKLNVNDSCNMLHYIIDQSFLYIKTRTRKAQRISPIIQRVRLMREEARNTNTELYETLQKEIKFFQLIDKYILDKEVILTDNVIDKIKIYYEKYKHSKNFNESNTINLFELNEVKYMISTLKSGKSGGRSGIRNEFLKNCPENFIYKHTQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ00</accession>
    <name>A0A4Q9LZ00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0254p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000254">
        <property type="protein sequence ID" value="TBU18107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0254p0020"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="228"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="338"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="439"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU18107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="651" mass="75853" checksum="3D1CF25ABF958EF9" modified="2019-07-31" version="1">MDMNRQNKYIDSLIFPLKQELKFLEREDDVLNFYRAKVMKKEESTHGDIITFIIVQAFDHNKNPILRKFDFERIFKEDESIKVLFDLKKTPSFCFQTKILSVNEKRYTFLTIIESLPREFYLRLDGSIFTTYKTLQRLKKIRKDGKYLDVNILNIINSIEETTREDYQKSDYNETENFSSSPLKYSEDFVDIFKNLKLEDKNLISMEKEYKDFIKKIKKLGFLIEYNKLNNSQKESLLFSKKNKSYRIIGPPGSGKTKVVVEIVKTLLYAKKSVLVCGPSNISVDNILSSIIDSEYYKKIKPKLYKLGSFLKTSKTLSCYHIESMANESVLPLLEKLNQAIDNKSDQKTIKALRKKVSEKKKEFIMSTIRCTDLAFATLFSSYKMKDNKYFDWIIIDEACQARESESFLSVLLAKKFILVGDPYQLGPTVKSETVELKSTFFDRICNTPTFFLNEQYRMSKLLISFSNSYFYSNRIISSKKTKFKFFNRSEILFIDTSNHNSKESKLNSSIKNTFEAEITIKIIKYLESKQNIYDVGIITPYSQQAFLIKDILPKVSFPIQVSTVDAFQGQEKGIIILNFVRANKQQEIGFLSDLKRTNVALTRCIHGLIIVANSATFLQDEFYIKLFGHLDAYAYCINPAIFDIILFKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ16</accession>
    <name>A0A4Q9LZ16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0250p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000250">
        <property type="protein sequence ID" value="TBU18156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0250p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12029" checksum="AAACE4831A04DB29" modified="2019-07-31" version="1" fragment="single">MKNGKKGEYVVVVGGVSNNTNNTSDKIYNTNNKSNNTNNNINNHTSDKIYNTSDKRYNTNNKSNNTNNNINNHTSDKSNNTNDKIYNNKSNNTNNNINNHTSDKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI3</accession>
    <name>A0A4Q9LZI3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0510p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000510">
        <property type="protein sequence ID" value="TBU13175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0510p0020"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="5">
        <location>
            <begin position="78"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="484" mass="56602" checksum="EE05399EB2443E6A" modified="2019-07-31" version="1">MKKIFEEKPFLQIKATNKTFLIEFPKNLIDTFNQAIDDQWIQITGIFILEKDKITITNDSKIEYTKYQIKKYSNPTDYVALNKMEMNKYCNVIGIVVGYLEPKQSKGSDWVSTIIITDESMETNKIFVKIFSKTPLFPFGFNNGDIIKIKNIKLIKPNIAITGKQNEVKLIYNFFTNNLYTENIYEENRITCLRNIYLENNQKYVRQLKICDLKETCYFDFCGLLINRQIEKNNLVILTLIDYTVNCNIKNVICDEEFANNMILYVKAWDKHAEMAKSLEINEIYLFKNLRLSDKDFILIAHMSELRKCTILNVDNGHVLRQSIYQEQERYKESFLTSILSNDEIPYGLSSLQTVPIYNIKISGLHRIKATVKFHFPFRILCLYFCRACKLTDINKNSIEEHVFQNSNCNIDKINICRFILKDTSGSCVALCRGKILEYFFRDENFSIHSTKPLDILIMSVSSDEGFKHHILDAIFDIKNSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI4</accession>
    <name>A0A4Q9LZI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0500p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10612" checksum="FED3B3DD9B51D699" modified="2019-07-31" version="1">MNYYSDELGLIYTFSVEIIFYIMNMDGIGTKYHYIDSIDNTYEDRKNVIKRAGMQGKPTYLLKKAILYEDSIKHVKTKSNQLFISKEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M013</accession>
    <name>A0A4Q9M013_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0166p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000166">
        <property type="protein sequence ID" value="TBU19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M013"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0166p0010"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="29995" checksum="9D51A29D5AD315CF" modified="2019-07-31" version="1">MEISNILEKILNKEKVISIKMNLERNYSLNESVEEMSDNALLCMSIYFIQGYLISDTDKEECIEFYKRYCEEVEYYRIINKSLIKIKENTVKQRITRDQKLFLYNFKKEFREIQRIWDNREYIFSVLKYLYILAFEEIYFLLHEREIIKALKEEKEEFQNKEINIIRVDERGKRSSVMVNRNKPTMDLDEFADREILRMRENSENQKEIQKNDSESGEEENLEELRRLDELKDEIFNKRGNTYGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M091</accession>
    <name>A0A4Q9M091_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-c protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0144p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M091"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020732029" description="Fam-c protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32985" checksum="2D0E3BF24B07606C" modified="2019-07-31" version="1">MYLERNIKCSNRLLVIVFIALCLNRICGNDITLDITGKSKCDTISNSNEKDNSVFRSRMAENVERRCIEGGEIKKLPQDITLNRNPNFDAKVKKINRNIYRDMGHLSNKKILSSDFMERKKVFENPSSTNPRFICKQSYITPFGKRVFYKKESNVTGNSTCEQNTYCDLKKEENISQKEEKINNQFEQIKLTSKTGNTEQKIFSQKVAEDEEITNQKNEKNIEVTKQRRIPKNKGYRVQENEFASFMKALKNHIEVFRKVPEFEEKYSEELKQKSKETKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M096</accession>
    <name>A0A4Q9M096_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0430p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000430">
        <property type="protein sequence ID" value="TBU13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M096"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M096"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0430p0060"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="36629" checksum="89C3834B0EB8FB9A" modified="2019-07-31" version="1">MINYNKETNYNKTYSNEKLEKSNESININNYNTIPFKIALLAATFYYLKEFDKSILLFNFIQNNFPLNLDFYDLFSNILYIKNDIKQLASLTTKCVELNPERPETMCVIANYYSLKGNHENAIEYFKKAITFSPTFTSVYTLIGHEYMELKEYNMAIYSYNKALKYNKTDYRAWYGLGKVYLSLSLKEYSSYFYIKASELKPDDSYIWLCLGQVKLLCNSIEESVSCFLKATTLGDIDGYLMIADLYKNEKRYYEAVIYYEKYVDECKERKEDIYKICVFLCEYYNEIGNTKKVEFYTKMMEEYEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A5</accession>
    <name>A0A4Q9M0A5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0273p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000273">
        <property type="protein sequence ID" value="TBU17655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0273p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="683" mass="80940" checksum="B70443971EC091B8" modified="2019-07-31" version="1">MKYIFTKKNLYELFVRIFFVCRIYSSLVTNNSARDILINRKDRAVIESKNSKNSIPLTPSLSEYSDVYASVLSQPRKEERNISVPRENYCSNEHINYYGTHRFCENTKSDVQLKNGSDESHQNFSNIQYSQNHCLERWSQNQFNGDNGMFYGSNNMPMLFPMRLESLIPIPYQYIDRSVSTEYESEFQNFKPGFNEYSGNKDPEVCLDQNTVAYPRYVDQQYIDLPSNVSLNRQERSSNSEITKRHDLPKRKRNDTILDSSNPKKICTELNTNFNIITHLQPSAAISFTEKNNQINNESVETESKYYQLAIKTFYCESYKYFLSFIPCLYQEIEFESHEKSFDLINTNPIFSHISRNNWNTYIDAQLDNYNSIIVDSENEFNRILEFGEGLIFYEKYFPSHVSPTQLICLYETMLSVLLKIKTESNFGLFYELIKFVAYYEYNLYDHVDLHHNLYVYFILSIISKQLKNIDLSIFLFIKVEKCTKDIICQPFDNKRCQEHRKYFYLQRLFSKLLLGMKNGKLRTKFYDIVIILELSSLKHHSKLFFNQTVYFRFYLRVLVSFLLEPKFNSSLDILDKFLQFSIDILNLKRDFTVTFSKEIKSMIEKFELGAFTVELNLKIIDEKFLPSSIETSFTDMFLSLNDIIMSEMCLSGYLSKIYECVNFDLEVMRLGLKVIYERRLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I6</accession>
    <name>A0A4Q9M0I6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0355p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000355">
        <property type="protein sequence ID" value="TBU13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0I6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0355p0010"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="327" mass="39159" checksum="E93B2DF87E02E14E" modified="2019-07-31" version="1">MVQKRKKSRRLTIRRREGLKRKVRDTKRKEIRKLRKLEKLKEKVPTSLLRTDEDILLLNQIKKNTEMRQNNPTVINLKLDWCDLLEKCDVFLQILDSRDPEGSRNYEIENEIIKNNKKMIFIFNKTDLITEEVKEEWISNYTSKGITCISDLDISFYINNNGFNESIFCIIGEKNVGKKKILSYLLSENISIENIHLYETEVKEKNILSSLRNPKAANIFEIKECLNYFIKNISVEKICQFFKTEKFENIEEFFEIIAKENNLYKRNGKLCHKKAMQFILGFFDTNKILFYSSFDINGSKLYNFKLKFNYSFLFKNRFNFSIKSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K0</accession>
    <name>A0A4Q9M0K0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1673p0010</name>
        <name evidence="3" type="ORF">CWI38_0132p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001673">
        <property type="protein sequence ID" value="TBT98617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000132">
        <property type="protein sequence ID" value="TBU20105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1673p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0132p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445378" evidence="1">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="204" mass="24217" checksum="3FE43C27A2F5F323" modified="2019-07-31" version="1">MKNNAKKFFLMILIFFNTNIISTNEHETIVNEIRCVKEKLYEINEIIAYKSRNVNNRKYFFSLDRQKSTKRRYCAQANITTDYSFTSVVSTQDIKEFSSMVKDLKEYLKTNPYKNFDFNKSDIFSKKMLDIFNSLLNIVSLIDCTNKDFNLKKEELNTYVCYLIDKYKTSLNLNCCGLLLEIYFFTISKFLIQIEILIVSLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N8</accession>
    <name>A0A4Q9M0N8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0113p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000113">
        <property type="protein sequence ID" value="TBU20204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0113p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13668" checksum="6BE5F60954F0AD10" modified="2019-07-31" version="1">MGFVEFRQIQDIFEKALSMNEDKEMCIKTKKLLGINVNFMVGILVEKKGQRGCLGWLIKYIKTGMWIESKENTFSKGYINVGSMRGGIIFFGRERFNIRQKVGIKLDLYLRKVYIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V4</accession>
    <name>A0A4Q9M0V4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0225p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000225">
        <property type="protein sequence ID" value="TBU18878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0V4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0225p0020"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU18878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="996" mass="112918" checksum="DA4BECC6138EC8C1" modified="2019-07-31" version="1">MLKNENTTDKTLCSEEIESAKLLGFKIVKILGTGTYGKVALCIKNSEINTCYYKDSDYHYTVGNKTDSVNDLYSNNGFLSKSIPFNTSTVNNTPNTSTVNSAPLNNSHPNNTLLNTNYTNNTHLNTGTFNNTLLNTNYTNNTHLNTSTFNNTLLNNSHDNNTLLNTNYTNNTLLYNNTNTTLYYALKFIRKDTKDLKVHFDRIKSEVQLHSLLNHSNIVKLYYSVQTKHHIVLVMEYVKGKELFYHIQQNTKLSEEQSRYIFNQILDALEYLHSHNIIHRDIKPENIIIGYGNSSKGVINSRGVLYNDKGVLETFSNKGVLDTISNKGVLYHNSNDNTLLDTSTVNNTLLNSSNVNTLLDTSTANNTLLDTSNDNNTLLEPDIEDDTSLNNSSYNNTLLTTSTNYSTYSNTPLTTTSTTSYISTPLTNNTINNTPLTNTTTPSINNTPLTNSTTTSITNTPLPTLSVKIIDMGFATLYDPKTTIKNYCGSPYYSPPEMINGSRYIGPEIDIWSMGVLLYNMVEGKLPFDAKSLNTLYSKINRGSFKLSNNISSSLKDLLKCMLCVDISKRITLKGVKTHVWTKGVCVNYCFERISYVDPLIFSKVVEYFSVCGRFLYRKGRVNNRDRVVERIKGVSYRGIDGGVNDRDRVVERIKGVSYKGIDGGVNHNGEGMEGNYKGVNERDSNYKGVNNKDSNYKGVNNSTIQEGLNYDCCMCYTGTCWDNTLYDLNKPIQLSNGTVNTLFNKLYRNNSTETKIYTLLQNKMICGVSLREVGIIRNVCFDSKMCCPILYSERGCMKQNSINFYAEKKCFIGECINNLIRNKGVNDSTVNNGYKYIDMNNSIIYDGGVIYNNGKGKEHINEILMDKKKNKPMCSLGWVFDKIKGFFKRKNVKKQIHHKTTLTCTNIKEIIYDLVKSYEYKVSRDNKVLSLLIHEPECVLIDIIVNGDFRIFKVEILYVNGCRDTFDYFCFRLMKEIRDMEDGRIVGEKYRSATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W1</accession>
    <name>A0A4Q9M0W1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0224p0080</name>
        <name evidence="2" type="ORF">CWI38_2483p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002483">
        <property type="protein sequence ID" value="TBU06931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2483p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15536" checksum="A64D3F38CC53FF1C" modified="2019-07-31" version="1">MTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPFISQGGTTLEEPTNNINEESDLEEVTKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X5</accession>
    <name>A0A4Q9M0X5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GATA zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0317p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000317">
        <property type="protein sequence ID" value="TBU15081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0X5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0317p0020"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU15081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="534" mass="64776" checksum="66A88D98B9A2D0A1" modified="2019-07-31" version="1">MIEDKSQEISCSNCKTRVTPLWRRSNDGSYLCNACGLYYKIHKSNRPHELKTESFRHRQRTRRSTSPMEYCDRSVSSERECVYESEKRYRRENDNFYDTENRECVYDSEKRYKREEECLFDKENRECVYDGEKRYKREEACLFDNDNREGTYDNQKKYRKEEEKHFYENRESNYDNQKKYRKEEEERNFTDTNLYFSRSKKSDRFFDKNFCDSKDFTGKKNDTVKKQNNEHLIESPLINPAIQKSMNPSLTLGNKKHNSNEYKYKSSNYSDDQDSHTEYPTKEYKDFTKEYTKEYTKEYIKDYSKGYLNDYTSKDYITPLDVSHTSLPLRISTTENITDDSYQYDRGLKRQGIDVIDRFTKINKGESVKYMKGGSKDYMNCGDENTFYGDNDWNKKEWNGKFSRRDMKRDEYIGEFSSRDRNKEDYISDWKRDDNKREDYISDWKREDIQKDELERKNTKNNKFIGSVSRVEFEKSTACINDLYKRVNYDKEIEYLDVLNNEKSFSEEKEENEKYFDELEYLAASVLISFMKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M107</accession>
    <name>A0A4Q9M107_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0354p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000354">
        <property type="protein sequence ID" value="TBU13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M107"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0354p0030"/>
    <dbReference type="OrthoDB" id="2190150at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="26347" checksum="5D08B069D0B931B3" modified="2019-07-31" version="1">MNSDFYLVRKVQEATNCTKEVAEKALLESKNDAEKAITAIKKKKGNDLYVGGYRSGLMVEGGDKKKIKTITVYKNGILVEDVFYDYKKKENRDLKKMLDNREFDRNILGEDGETAEVVFNDRENEEYKVKVEHFTGTSHTLSGKKEKEIECPDSIIVDEDGDVFFKVLLSGRRIKIQISSKKTVNDFIIYMKKYTEKEYELYDSETLVERKSEISSVKNSLVTMKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M109</accession>
    <name>A0A4Q9M109_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0086p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M109"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0070"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="215" mass="25005" checksum="1229A129955F0A00" modified="2019-07-31" version="1">MCQYCIKSGKTVDHLATRCEKILGHDYTRLHNEVVRCLHLFSNLIGHTVQEILENEHAEIRVDTRIKTDVKIRNNRSDMLIFDKKKNKITFIELEITFQDSFKYTRNDIVTKYHKPSVKKPKIPHNVEAYIQSIVLKKTVETISFDRRRVLESGLNAEESWETASMGVIMRAKMHEEPTPPLKEAKREEDGAKNLKPKNNTPLISQRNHVLGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M146</accession>
    <name>A0A4Q9M146_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0086p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M146"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0020"/>
    <dbReference type="OrthoDB" id="416119at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="427"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="73136" checksum="98DD6EB09BCE6C4F" modified="2019-07-31" version="1">MVDLKKYLTKNKRKLIIIKRKNVSSEISKNNKIKAENIADEVKKSDSGVQKCELHPPAISLPSSSYTAITPPPQSQTCSKMQNSGLDSIPSPNTPLPSMVMVSALMALRTIFDSVTADPKKWPRIVFFAVQTRSFKGTIWKFGCTLDIDAFKKFAQNEAKREIRQEENGERHIIATCRTEPCTLTDTLEYINPRDKFLSKIKEISEKEILKLVVRTRKLSSELVDSKVLDLIFRVVGEYAGAHVPESITEAAYIMQAAQVCYDEETRKEKPRSAWKENIEKKARKQEKLSTSETKCLKKIMREFNLNLSSVTDLSEALIKKNESLNVSRIKLRCMKVGSNSEKRIVSLTFFEIDSIEDYPIFGQQCGTKMMTRSHNHPNTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIEKLTTLHKYIYDIVKVICLEGTPQADWFYCGLTYLIPKGTPKTGSDYRPITCMSNLYKLTTKCVTKVVQVEVERRGLLSDNQLGAVRGVQGAKEQALLNVAINKDLDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVRPEKIMSKKIDRGILQGDSLSPLLFVLCIDPLSQKQCEKYTKVTTHAPLRNIRKILAYFDHIRHGHVKQQAEMFFKEPIVLNIIVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M176</accession>
    <name>A0A4Q9M176_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0078p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000078">
        <property type="protein sequence ID" value="TBU20385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M176"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0078p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20259" checksum="30A76A3028EDABF1" modified="2019-07-31" version="1">MPSSSDKSDNMPEEMNIENIYDHQVEMELKYLLHTVFETYFIYSQAIVQIQNKRIEGLSEDQSSDIVSFLMELSEARLMTFHKILGFGLTNIHNFEFNINLKTENLFLDLKDVPSVFTKRETFYNELLFSMNKKAAEMDICELVEFLNSLIPQSVISLQDDYKRIMKLCHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R4</accession>
    <name>A0A4Q9M1R4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0044p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9394" checksum="3845B42F72209A1A" modified="2019-07-31" version="1">MSIQSIVLKKTVGTISCDRRRGLEASMGVIMKEELHEEPTLPLKGAKRNKDGVKISKTKNNTLLISQEGTTLEEPTININEDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U7</accession>
    <name>A0A4Q9M1U7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0168p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000168">
        <property type="protein sequence ID" value="TBU19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1U7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0168p0040"/>
    <dbReference type="OrthoDB" id="2400393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="151"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="49765" checksum="5493A6B8B077DD5D" modified="2019-07-31" version="1">MSKKIHIDSSDDDFTNFVDDNENEENDNDFSSDSDIIVNKRSRTIPLPSTSSSEEDVSETRDNRPWKDVTIEDNPPKRFDFISCVTNEGPQIHVDCTKPLDFFKLFFTDELIEKIVTEINRYARNKITQKRLSKRSTWHSNFRLSLELYYLDFLDERFKEHFVPSREISVDESVVGFKGKISFLTYNPNKPTKWGIRMYVMADANTGYVYSILPYYCSLTSEDLIRPDLPVSTRIVLELCNKLLDSNPGNTGYDIFTDRYYTSLPLAQELLKLNIHFTGTIQSNRKFSENNTFACRSGNILLSAWKDKRIVLALSSWDVSGTEPVNLIHKPHIIVNYNKYMGGVDRADSYATSYCFLRKSLKWWRKLFFWGLEASSVNAYLLYKIVQTRQNKRPINHLKFVREIVDKLTQNYREGSKTYGRPSTTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M274</accession>
    <name>A0A4Q9M274_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0016p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000016">
        <property type="protein sequence ID" value="TBU20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M274"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0016p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="6925" checksum="FB04FBA077A9458C" modified="2019-07-31" version="1" fragment="single">MNIYNTGWQLKKNISKNFEARKKKIAPWLGLGLGLGLGLGLGLGLGLGLGLGLGLGLGLGLGLGLGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I2</accession>
    <name>A0A4Q9M2I2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0112p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000112">
        <property type="protein sequence ID" value="TBU20208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2I2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0112p0030"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="31258" checksum="2A6A11B9B5711D85" modified="2019-07-31" version="1">MEFKDKFDTFIMDWKTPVISSFLYMAYVQYENKRISQVTPPQRKKFSLLTLMMVLHNLILCVFSGIVFYKTYNILLDCYKKSTFYNFLNDGNKFLYKKMIFWTKLFYLSKYYEIIDTIILHVNKKRTSFLQMYHHAGAIICCWMLAKCESHVPWIFVVLNSFVHTIMYAYYSLTCLGIKTKYKHLITKMQMTQFVMGNIFILIHIFKGDILKNENIFTSFKVLALLSNVFYVAVLFGLFNQFSKQTYSKRIEERKKPIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N2</accession>
    <name>A0A4Q9M2N2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0001p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19917" checksum="6015B6566394F240" modified="2019-07-31" version="1">MKITEYTTGYLIPIKISIPLFSFETKFVYNIKSSLNLETFIDILLVEFKSSITRRTIKESSLKNVKELLKYQISHQIHYFNSLINNPRIRDTSYDVPLKISIEKESISIKENIVLPSFINYEIEIFCNDFCIENNVSTEFSGEMSFSLREQIMCFFANISQEMSENTSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T2</accession>
    <name>A0A4Q9M2T2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0158p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000158">
        <property type="protein sequence ID" value="TBU19992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0158p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="25520" checksum="16D95FA4D3837966" modified="2019-07-31" version="1">MKFYEETNPHLQRLSSRFYDLSKETDFIAEKERQAYTFIERNLIKDTSIDFATVFEERKLERSYFEYYNNENNYFEEFAFTAKVYYDSCIQNEFYAIPEKESPIKAVLTKLNSKLESLMKKMYINKVLLKILIDIFHGNDILYYISTEDQSFYTYNNLLDTNQRIGFFIDNFVNHLYFILKEKFEGLSFPKCKKKLKFKGIDILLKFLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Y7</accession>
    <name>A0A4Q9M2Y7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0081p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000081">
        <property type="protein sequence ID" value="TBU20378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Y7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0081p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="351" mass="40614" checksum="FBB2A7BA0219C4CD" modified="2019-07-31" version="1">MAISNFYSSNRILRKRGRPRLVVKIREPNEETVPTRPKVPIKIPTICCVCKKPISAPLTKFEKGERAQWYCEECKNAIIKEGPKRINTYGELNKKQKNETVGLQKALNQLIETKTKSIYDESYRQSMLRIEKEINKLKVLNNIVHKKIPIAMNVNETKVHIKDHKPKTVDKPRQHPTNHRPFSKLSHEQILQVLDGKSPFTPSRYIFIYINNIKVNKIKFYKLAIESLSEGTSRYIINMDFINDETAEIICREDKKEIINEAFIKLSGNLLSRSPEIDDNGTLHIGMLFERMRKIINRSTNTNSKLRQLAVSILYTKRSELLDVLKSVYIEANDVNMEPRSGSLSDNHING</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M357</accession>
    <name>A0A4Q9M357_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0069p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M357"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0060"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10424" checksum="4D01F5D3FFFCA56B" modified="2019-07-31" version="1">MNYENPYTKSKPYFTGNRRFKATKDLLKNQKNLKMEKVIINKSKLDEEGWYNIKTPLLTEQVENDLYYIKNRDILGDGMFHLGKYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3A4</accession>
    <name>A0A4Q9M3A4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myb-like DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_2475p0010</name>
        <name evidence="15" type="ORF">CWI38_0036p0060</name>
        <name evidence="14" type="ORF">CWI38_0909p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002475">
        <property type="protein sequence ID" value="TBT97139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000909">
        <property type="protein sequence ID" value="TBU12076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000036">
        <property type="protein sequence ID" value="TBU20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3A4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3A4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2475p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0036p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0909p0020"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBT97139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="368" mass="43178" checksum="B5A6E268CAD52DA2" modified="2019-07-31" version="1">MTIHQKDKIWTNLEDQILKAGIMKYGINNWSKISSLLTHKTPEQCQHRWNTYTNPHIKNTPWTPTEDTQLLNYIKVFSYHYTLISQQLNRTPQQCIDRYNTIRNTSRSSDTSRSSDKLQSSHTSLHTSLHTPDTHTSLHSHISQPDPIDFDIDSQQMLNITKNRLLNTKTRKQKRKEKLKNQKPNKNKEFDFLKNAPTLQPLPGIFITEKEKNCKTYTVESMNNKSDNKFDNKLDDKESNCKEISFNAELNCKETELKEEKGLNCKETEIKELNQEIKETEIKEKQLNTKINSTDKYPSPLNITPLLFNTPPNLHLKNKKIFFLKEIFNNFKLPPLNTIKHPLKINLNIKNILSQIPPTNQSFLQFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3T3</accession>
    <name>A0A4Q9M3T3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0101p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000101">
        <property type="protein sequence ID" value="TBU20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3T3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0101p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="40216" checksum="3F3AF41FF6F7C378" modified="2019-07-31" version="1">MFYSECVRYFPDRLYDLLNDINLFTGLSSEKIKGSLSNLNVFGKDEYFINPLKTLKQWNKKKLTMKSNQQEIVKIFDDFAKNQRISQLIFSFFCLYWDCFLSPVNEIYSIEPSRVLELSKRQNRTSEKYNNDEFFKNLELIYKNNERKYSPFFFSNTVSLDAHHEFENTIFSNIRPVKSDSESIVDLNNCNEINFSIILESEYLIAVFICDFIQNIIDESEFSTMFSSENFSKNEQLALKEIYEKIESIDELEPFKSEISGSLTHYLNLFKKDVHLVFAFQSLNSVVSVFTKQHIRDKVFGNQKIYKILFDLYKKYLKRSAENSKKIKCVKSIDYMDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4U3</accession>
    <name>A0A4Q9M4U3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0046p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4U3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="26556" checksum="4DB1F2C1E54CA2FA" modified="2019-07-31" version="1">MESVGTIKKIKEKKKTNNKWNEIRTSYACVPDNEYNLNSFYTPQFDDDSLHELTSDEIEMIKRWKDDPLPIVDKNGSLYLTYTNTSVNDEIISENNDSKPILPLSAFDTHLSQNETNNDKELIVSKKWEISSVDNSKSDLEPVISIVNQKGKIIGIKNTVYNLLILTLFTVLIFSWYQNIQSVHNYVYTAFKYDSYSRFAHLSIFVQKIIYYIQYIINNLKKYALYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5X5</accession>
    <name>A0A4Q9M5X5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0003p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5X5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5X5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0060"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="436"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="709" mass="81063" checksum="60766A895744F28B" modified="2019-07-31" version="1">MSHFESQKVHTFYKNNHTHFSNTRYIIWPYIRTFLSTTYNPTHLILDNGCGNGRCIMYNNIIGMDYSRELLQHITKGNSSRDSSVYGSGSMYGSGSRDISRDISNKDNNYISNTNISNTKDNSTSNPSTINPSTYNPSTYNPSTYKTNNTTTNKTNNNIPSPLDLLRGDCLYIPFKNNTYNIIISIAVLHHISTLERRIIFLKEIYRILKYKGICLIGVWSIKHRNNKRFIECSGVGGSVGEGGGEECGMDKGYVNTSNTSNTIRDTTDNIIRDIKDIKDIKDNNNISNIKDIPFSYGDVYATWNNVSVRYVHLFNIKELCDMCVSVGFTIEENKEVGGVTIEENKEVGGVTIEEVIEEHETLYVRVRKREHLIKAVFGFETALIKKIIQTKHAVAHIGVNKMMALIVQKYYGIPKAYIREYVKDCEICSQFNSLKTIQPVYINHITKKYDLFMMDCILNVIDTYTKHLYCFKLINKTSELVRDSLKFLFNNFGVPVAIQFDNGRKFKNALLEVFLTDLNIKIIHGRPRNPKAQGQIERVNRTIKRSLAKKLHDTGGRTGIEDLNNFIYAYNRSVYSAKNKSLFMHFFEQPGFNNPLSRSIIVENEASTIVPAIDIDPDIVLVEENAADTQWILEIASDVHEEFTETVTTTTTIKADDREIDSNIRSNGAKHFKNYRERIIESNNSNGLKKDLSIGNHVLIKKTLRYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW62</accession>
    <name>A0A4V2JW62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2514p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002514">
        <property type="protein sequence ID" value="TBU06742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2514p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17357" checksum="1B757DDF3D174B0B" modified="2019-07-31" version="1" fragment="single">IVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERTSMGVIMRSEMHEEPIPPLKEAKTEEDGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX51</accession>
    <name>A0A4V2JX51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1722p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001722">
        <property type="protein sequence ID" value="TBU10492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1722p0020"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15601" checksum="EB12B0B6604118F7" modified="2019-07-31" version="1">MTWDGIVTKYHKSYIKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPTLPLKGEKREEDDAKNFKPKNKAPFISQGGTTLEEPTNNINEESDLEEETKVVKEVEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX68</accession>
    <name>A0A4V2JX68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M48 peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1618p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001618">
        <property type="protein sequence ID" value="TBU10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1618p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="177" mass="20309" checksum="D17826E3DDA3ED67" modified="2019-07-31" version="1" fragment="single">LGNDIFVKQTGSFFTNGFFAINFVTKHIILDGGIFKYKYAIEGIISHELGHAMEARFILFATLTLQILTFVSILFIIDCLVSKYFVDENVSRDCSSIILYLFFLSYFKVCSKPMDNILSQIFEFRADSFAKSLSQHIPLAHSLFFISFNKAPFVSSKLYSTLLYTHPSTYDRLKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX70</accession>
    <name>A0A4V2JX70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1643p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001643">
        <property type="protein sequence ID" value="TBU10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1643p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15664" checksum="B1A6D9BC46C8C216" modified="2019-07-31" version="1">MLKYVFQDGNLILLENSKDSYDISFLDEHIPYKNLLIKNFKLFCCLENILNEPYFLNTFKVILNEMNIKSLIINGNIACIIPYKKYYFRILSFGLFKSLVIANFDSPPRSFLYELDSVIDKNIEFLSLRKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE3</accession>
    <name>A0A4V2JXE3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannose-1-phosphate guanyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1179p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001179">
        <property type="protein sequence ID" value="TBU11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1179p0010"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="157" mass="17854" checksum="F80FAD38963D3012" modified="2019-07-31" version="1">MRVDSGYYFQINSIEAFIKASLAKKQSSFIPQWILNGEGEIFEYKNCCRQTLKKISFKDQNEDVRNIVGKKFLPGDFYLYNSIIGNNCRIGKGTRILSSIILDNTKIGENCLIQDSIIGESVVICDRCFFKTCKIMPKYVFSEAIKASSEIFSLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW0</accession>
    <name>A0A4V2JXW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0468p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000468">
        <property type="protein sequence ID" value="TBU13322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0468p0010"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="29707" checksum="84D5CE72F63D06B4" modified="2019-07-31" version="1">MNILFTTFEITTVNKSGFTKPLNDDFRSTIRHICTLKTIENLGYFLRYLKPIESCESVCDINVFKQGIQPLWEDENNLGGGKWIIKLRKEVGHRLLERLIIHLIKGPFSTTDVNGVVASIRPKFFILSIWTRTCPKTNEVKNIIKEIRNLLKVGNEVEVCFKDNDESLRDNSSFKNTTSWERASMGVIMRSEMHEEPIPPLKEEKREEDGAKNFKPKYKAPFILQGESTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB8</accession>
    <name>A0A4V2JYB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0067p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000067">
        <property type="protein sequence ID" value="TBU20463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0067p0040"/>
    <dbReference type="OrthoDB" id="5570375at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="411"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1019" mass="117455" checksum="E7611881C4A8F447" modified="2019-07-31" version="1">MGRRKKVDSENIKNEKIKAVKNLKSPGEIFMCDVDVAMLSERLPPLPTFQDTTHQPPSSSCQTSPVCLVETIPSSSGTDATAFGPANGMTNLNTDALLEGNRLMVLHTILDSVTVVEQECPRSAILAVQKRFERMPRNGWPATLRYYNEKFSCTLDIDSFKKLAQNEAEKEMRQEENGERRRIATFLTEPCTLTDTTEYINLRDKFLSKIKEISENEIRKVVVRTRKLPSELVDSKVLDLINRIIGEYADSCVPMTITAVARIIQAAQKPRSAWKENIESKISKLVLSKDLLEKAQFNLNLSSVTDLSEALVKKNESLNVYEKKITMYENNRMFELYRGRFYRGLSKRGESEHVVSRDEIVSFWSTIWNKNDETVTYIIIIFHFWLSNGKAAGIDGIYNFFIKKLTTHHKYIYDIVKVIYLEGTPQVFGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWLLKFIKVIISKWKIYISVGPEKIMSKKIKRGIPQGDSLSPLLFVVCMDPLSRKLNEKYTKVKVQTDAESHSTNQLCFIDDLKLLAKDSSTLSAITDEAKEFLEVIGLEINKEKSATNDTCCEDTATFLEDVSVYKYYRIIEHSRGIPTRSSFEEIHLRPRCKERLYLSRTELGRGLHSIELQSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVNYRLVEEVIKKSLEEAQLAKLYNEIEKRKLYSKLYNARKNELVSVTVFCYIQDKNVFWGADGMCQHCNKSGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEIKTDVKIRNNRPDIFLLYKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELCLFYKCSVDIIPYVMTWDGIVTKYPKKYVKRLQIPMNEEALYNPYILSVILRAEMHKQPIPPLKEATTVKEPKININEESDLEEDIQVVEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM1</accession>
    <name>A0A4V6MVM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0862p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000862">
        <property type="protein sequence ID" value="TBU12182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0862p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19765" checksum="41DDD61E76006E71" modified="2019-07-31" version="1">MNSNNKETDKVLGMEKYIIATTDSKIGTINFSNEQNISITGDLRQIFEINHENINIKELNEANYLCKNADIMTKTMKYDISLSYLPISFKLLFNFLVVIYMLTRTVFNLCLILYSLFFHSLLILFISISLNQLLIFYIFFQIYFYSNFNFILSLFTVFASSSCFIADNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVQ4</accession>
    <name>A0A4V6MVQ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0011p0140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVQ4"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0140"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="3">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="339" mass="39965" checksum="DB5D8789C214C1AA" modified="2019-07-31" version="1">MVKNKNESIEKSKYEKYLHSLSKDQLIKIIFPPVNFIKNKYIKSYKKIALKFSYYGKNFHGLVMQDNKDTVELRILRVMYYNGLINSFISNNISFAGRTDAGVSAKNMVMSVTFPSILTEEENSNILKNTVEKNNSNENFILEKNKEYDYIKMLNSGLPEEILIHSYSLVPKDFDARHSCISRKYKYFFRSNNLNINLMKEICKYFFEVKNFENFCKKSKEKEFKKKGLEIDKTYYCRSLTSISIEMVEDSVYCLNIKAKSFLHNMVRKIFWVLQQVGLNNSIDIFYKILNGDVQCGTAKAENLLFYGCEYDENLYFLGSNDNKNDYIIERFIKSEIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KY49</accession>
    <name>A0A4Q9KY49_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1185p0010</name>
        <name evidence="6" type="ORF">CWI38_0581p0030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001185">
        <property type="protein sequence ID" value="TBT99873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000581">
        <property type="protein sequence ID" value="TBU12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KY49"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KY49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1185p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0581p0030"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT99873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="619" mass="74077" checksum="715D7186E3E9848E" modified="2019-07-31" version="1">MSDDSNYIPPFVLPLPTIYNYSQFISNLVVLRNKYDPKVTSSKYFDELTVEDTKISKLSLFVPKKIYDDISITKVSSGFLQARLTNKMISINKETVSFVRKSLLKKICDLKSKKYELKSFYKKISSEDLNNLETFFDIEPPKEIFSSSSLYQIYSFLKERTEINEGFEAEISCLEYQYLSFLNRFLKENSHKISDKCITLEDKVRIFCLLRFDKNQKNLEVYHKRYLYAEIFVYFRMGKIMEIKNLFRENLEFFSHISNEFDKMFVEWYEFPQKRKNIRAKSMIMHDKLKTENCDAFRLFFYRLMAQLDILKCDSIVLNTFEDFLWFELINFEFINSRKKIISLFASLPVVPTFFVTTMMKYYEKSLDMILLSEFNLCDCYYISKELGKFVNYKTFVELVFFICIKFKDVKRTVKILKKLKEVLDQNTYIDVISENIIKNDLFEILIGENNEMVFEDEIYKRITEKIKDRNETSLLLKIYYLFEDDTLILNTLKNILQDSILNEASDQIPFADIIRYYEKIGVTSEWRNVKILKDFLNFKLNQTDETFNQLVFFRDEEIEKSFIIEAKYVFEKIVMLVSSYIQRHHRNDLARKVFIISGELGLSEDCLEYVRSKLVLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L030</accession>
    <name>A0A4Q9L030_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0933p0010</name>
        <name evidence="2" type="ORF">CWI38_0144p0070</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000933">
        <property type="protein sequence ID" value="TBU00668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0933p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="248" mass="29218" checksum="624B2496C462C168" modified="2019-07-31" version="1">MKDRVFINDLSKICSVNLFEEIGTKDFDDLLPVDYYYAIPHTHLYAAKCFLPNNSKIISTDIDMSLDSHILGAINIYNLDDIGINMTIINIRFENNILQGDYNRVIQKIYDCKGYYFRFFIRIINTYTETVRILDPRLILENIKLLFESEILTKETPVDIIYLPVLKIDKLVGSMKNDFSIICDGLRYILDEYRNKGRIIYGKHLENKKLKEYIENGFIDGVMSDEIISFKEFVEYNNLIYKYEIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3N2</accession>
    <name>A0A4Q9L3N2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0561p0010</name>
        <name evidence="3" type="ORF">CWI38_2609p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000561">
        <property type="protein sequence ID" value="TBU02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002609">
        <property type="protein sequence ID" value="TBU06258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3N2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3N2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0561p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2609p0010"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="392" mass="46596" checksum="135ED7F7EDEE2926" modified="2019-07-31" version="1">MTENTQQRRRVPGIKEHLDAISRINSEINSIVETVKDYESKVSTEIALQRENSPRTQLYQKKDQLETDHKATLSIRNTLISKKQEILPTYTSLKNEMHSEKKKLHIDNFSQLEKQESDLKSHLLKKKVTAQEEKMIASQLSEISRKKRSFGTIKTKEEELSKYEEKLEKLNKELNEIQTQIKTEKEQILSIKTELEKLKTQGKTKSNSIIDYENKIEDLNKKKKDLMSKRKEQNEEIRKKQEIYEKHLQEIKKQTEIEESKKHIKIRIKEYEIQRNNLIEEKYKLDSDNFNSIIEAVKKIPISHQTFTMPISLISLLNQVQVNLPKNYQDIDRCIEELFKKKEEFEKKIEPNMLRLNKQIQEIDEKIKEEYKVLEGMPPTEVKVYKEKKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4Y3</accession>
    <name>A0A4Q9L4Y3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0446p0050</name>
        <name evidence="3" type="ORF">CWI38_2128p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000446">
        <property type="protein sequence ID" value="TBU02607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002128">
        <property type="protein sequence ID" value="TBU09681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4Y3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0446p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2128p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="269" mass="32425" checksum="C5C32FAFF8E2C106" modified="2019-07-31" version="1">MNVILLFLNNFSHQINHKEKNIENIIDYCENEIKSQFLTRSTEMDSLLEREFLFLGLYKNLFNIYYYEITNFIMVNLPILLNFYIFIIYTNQGTKCVKVSHKILSISYQTIIIKTKQNKYSIEIENLFRFYVLNDKYSQKYILKKFLAYFLRKLFLIQQSIDYILSITITGRCFIVFTDIPPKNFRKTNFMFISLFLHSLHIDNNYLHILIINKHEINIYYDDKNPQRGIIEFSFSNELYVMIANFSFSRSKIDENFLKNNFTDIISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6B4</accession>
    <name>A0A4Q9L6B4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0346p0020</name>
        <name evidence="5" type="ORF">CWI38_2247p0010</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000346">
        <property type="protein sequence ID" value="TBU03157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002247">
        <property type="protein sequence ID" value="TBU08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6B4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L6B4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0346p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2247p0010"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="338"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="432" mass="50270" checksum="44FB216448A37D97" modified="2019-07-31" version="1">MSGETETSQTVEKNTEWDTKKDNEKKSDTSKENSTYEGRESRWDTDSRSKRDGDNDYSQFDNQNERSMGRSEGEVKRNIDDADVPVIKGWGNDDGDFSSNKKKYESDRNDNYGRSDRRPPRRFDDQRNNSYDTGRGRRGDSYDGERAYGGRNKERWEEGRPSRRSEGGERERRQDDGKWSSEGRERKTGGWDGERNNRSEYPRKRRLNDEYAEDRERGFDERKPPRRYDEDRSFGDFRPEDDRYERNTDFRRGRPGEEGSYGREGGRDDFRRGGSSYKREGYGTEGRRGYRGRSEGRDREAFYEDSIDRRDSRRGRSGDEFGNKRTKRPVPVNPPPSKVIGLFGLGVQATIEDVKDFLMENIPDVAYDNVHLVKDRETGDSRGFAFVYFSSIDASISAKEGLLGKSILGREVRVDYSISDAPRPSRFNEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEF4</accession>
    <name>A0A4Q9LEF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2589p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002589">
        <property type="protein sequence ID" value="TBU06373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2589p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="25290" checksum="721D2567F4F9DF45" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPQAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLTSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCSADTCTLTDTTEYINLRDKFLSKIKEISENEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEU4</accession>
    <name>A0A4Q9LEU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2661p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002661">
        <property type="protein sequence ID" value="TBU06005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2661p0010"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="15074" checksum="FDBF1C3161EABA4E" modified="2019-07-31" version="1" fragment="single">DGIVTKYHKTYLKRLQIPINVEAYIRSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILSLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGZ8</accession>
    <name>A0A4Q9LGZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2408p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002408">
        <property type="protein sequence ID" value="TBU07383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2408p0010"/>
    <dbReference type="OrthoDB" id="2198700at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12441" checksum="42A4EA902DFD8CBD" modified="2019-07-31" version="1" fragment="single">MLLQLLDCLEKSKEISSRRVAILKVENTNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKHHIKLYNARKNELVSVSDSSRWLKRGNIRPRNEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJB6</accession>
    <name>A0A4Q9LJB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_2377p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="PITK01002377">
        <property type="protein sequence ID" value="TBU07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJB6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2377p0010"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04100">
        <property type="entry name" value="Asp_Lys_Asn_RS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="155"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="53250" checksum="B0EB0244EAAC65F7" modified="2019-07-31" version="1" fragment="single">MTEKIENQIMDLSIQEESIAYKKVQLTDLSKDFIGQKICTFGWVITCRTTKAGMFIDLYCGFKTIKCLYPREFEHKSISKWTSLTIYGEVKENYKHSKDSSEFEVHIDRMEIFGGKQSPPFPINNETLPFVKLEKGHLNLRTEERIFFLKARSCLMRHFRDFYYKNNYIEITPPTIVKTQVEGGSTLFNLKYYGSDAYLTQSSQLYLETVVPVTQKAYCIMPSYRAEKSNTTRHLSEYTHVEAELADLNFSDLLDSIEKLVSYVISKFYEEMRKDILILNPNFEFLKVVEKPFKRIRYTDAIEFLRNMKYLKEDGTEFVCGDDIPDAGERFLVEKYGEGLPVFLTHFPVSFKPFYMRKEDEDNTFTESCDLLFPGIGEILGGSMRCEKHSELIEGFKREKIDTENYFWYTDLLLYGPFRHGGYGLGFERLLMGLMRWESVNKACLYPRFLTRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKE8</accession>
    <name>A0A4Q9LKE8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2349p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002349">
        <property type="protein sequence ID" value="TBU07801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2349p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15541" checksum="DC928EE891DB680E" modified="2019-07-31" version="1">MNIGEKCLIEIFNLESLEALIFESCVFESITDLHLFNSKPKYLKFLAFYSTNIVIIDKLDILSKLDFLEKFELSYCENNLGFLTKLSSMCNIRLNIMSLLHCNLILNDLNIIKNFEVLEDLNLTGCKFSNFGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM73</accession>
    <name>A0A4Q9LM73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2155p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002155">
        <property type="protein sequence ID" value="TBU09384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2155p0010"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031544">
        <property type="entry name" value="WD40-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17005">
        <property type="entry name" value="WD40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="11007" checksum="DF542F62A7BF1C1B" modified="2019-07-31" version="1" fragment="single">MKFDENNTEYNLSKLDEETYENKIYAIDCNIDRSLMIFGGIKNILWIKHSQTEDITAFEKYSDSVIFCKFVDKNTFLVAILNGEIYKYTLNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNT7</accession>
    <name>A0A4Q9LNT7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2060p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01002060">
        <property type="protein sequence ID" value="TBU10059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNT7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2060p0020"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="57"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="375" mass="43637" checksum="50F0E459BAC24027" modified="2019-07-31" version="1">MLPPECSHSIRLGNLCVNCGKEVPNTELYSTLYTNSFLKATKKGIKKITEKHTTEMLKSKKLALVIDIDQTILHACPGHVMFGSILPEIHHIFVNSSPITIKLRPNLDLFLSSLSKIYILHIYTLGTREYANKILELIDPSSFLFSNRVMTRSESDSTYKDIQKIFTSNKLHTVIIDDRADVWNYCNNLFLIRPYKYFEYGDINEPISVSTIPDTSVESNTEINLSTNKIAEEKNKIEQNSFISFQEKDKDLFLILNILKKIHKKFFFNCKKDVRKIVKKYRNKVFGGTNIHLCFNNLEFKNFIEILVEFYGGKCVDLRSANIVVGNNGLDYKWIFESIFCYRMVDYDKYKSDTVSNRKCSCNDWEEEIDKEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPI1</accession>
    <name>A0A4Q9LPI1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1839p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001839">
        <property type="protein sequence ID" value="TBU10338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1839p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25401" checksum="BFC8F25AE40C8228" modified="2019-07-31" version="1">MKFTQTLLKCQANEWKEWYIAYQKLKEIIKKEPEIFKQSLLNELNRINEFYIFIEKRALEEKEIVFSSVLGDAHSDILEVQPFRNEESSCDKCNDSKDKSNVKGSVQGKENNINEVFNSNITDINDSNINNHYTDTDINNNINECNIVSNPNLTLESCINNSPNPSLTLNPCINNNNNTNDSPVTFLKINSFFKKHSLHRKREKLLIDFISTLSTIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPP4</accession>
    <name>A0A4Q9LPP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1971p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001971">
        <property type="protein sequence ID" value="TBU10167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1971p0010"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="24838" checksum="EC7357456396FB6A" modified="2019-07-31" version="1">MPKIVSFKNRQEKEILTAYLKTGQNSAGYSKEAKRLLRHKAEHFTSFGDDIGFKRRDQIIRAVQSQLECVNQTIKRWLAKKLHETGGIRWVEHLNNFVYAYNRTIYGTTNKSPFMLFFRQPVENDARIIVHFINIYSDMILEIASDIHEEFTETVTTTTTIIADDLEIDNKIRSDVAKHFKNYREIIIESSNSNRQKRDLSIGDQVLIKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ20</accession>
    <name>A0A4Q9LQ20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1987p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001987">
        <property type="protein sequence ID" value="TBU10146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1987p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="17002" checksum="7C2F88EC2D446DA1" modified="2019-07-31" version="1" fragment="single">IYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSKVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ44</accession>
    <name>A0A4Q9LQ44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1663p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001663">
        <property type="protein sequence ID" value="TBU10589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ44"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1663p0010"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10728" checksum="63CC7E49FBA84855" modified="2019-07-31" version="1" fragment="single">TKCVEERWDTLLPINGNKNEDFRIKSENVDLQEISDDKEDQTALSFFQKIYEKSSDDVKRAMRKSFLESEGTVLSTNWDDVGNKKVDPASKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQP0</accession>
    <name>A0A4Q9LQP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit alpha of pyruvate dehydrogenase E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1693p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001693">
        <property type="protein sequence ID" value="TBU10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQP0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1693p0020"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="4">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="25692" checksum="D81A2CAD16E422DA" modified="2019-07-31" version="1" fragment="single">MKAENSLIKINIDASKFSFHMLDSKDLNFSLEYSKDEVIDIYGIAYTIRLFELECEKFFNNKQIRGFCHLVIGQENIYAALKKVMHTDDYSISSYRCHGLAYITGSTISEIVGEMLGKAGGNSKGMGGSMHLYNKNFFGGHGIVGAQIPLGLGLAFSQKYKEIANTSFPSESNEKAAHEHSKSNANQSIYNNFPLKNVTFCFYGDGASNQGQIYESFNMAHLWKLPVVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQP9</accession>
    <name>A0A4Q9LQP9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1687p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001687">
        <property type="protein sequence ID" value="TBU10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQP9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1687p0020"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17706">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="301"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="730" mass="82184" checksum="5F45EEE4639EFC0C" modified="2019-07-31" version="1">MSDNISSFLSSFTSYITNLKIQPCPRLVLNLDAFRTFSKEFTSYLINNPLTLIPHVENILSSYNIKHIGTTGSLPSSILTPRTLSSQFLSKIVCVQGIVTHITPVQPKVVLSVHHTDTTNDIVFYEKEYRDSTMLSLLPPTSIYYPIKDHNNTPLVSDFGLSSYMDYQSIKIQEMPENVPPSQLPRNIICILSDDLVDTVKPGDRVLVYGVYRCMSQGSKEIPNYFTTVVLVNNIKLLSFGNKNCEKENEEFKENSIENLRNENIENSTNFNSIKENDIDNTIETSNTNIFNSYSIVSPIPLQNIYNSIAPSIYGHSTIKKAVSLLLVGGNEIKMKNGSKIRGSLNLLLVGDPGTAKSQFLRYVNSVSPISVLTTGKGCSVAGLTCCIKMGEDTVIEAGAMVLSDMGVCCVDEFDKMSAGDRVGIHEVMEQQSVTVAKGGIYCILNARCSVIAAANPVLGYYSEKMSVGENVGMGNSIISRFDIVMVVKDTNERDREIAHHVLNNRSGKIQSKSNYNISNDCISQEELKKYFKAAKEIRPVMTKEAGDYISKYYVSTRQSKPDLTPRFLETLVRLATAHAKLRMCHRIEEEDSISVVEMMEEIMSEESKFKGSKKRKIETRKNLVNEEIILEEINERDDLEERKGDFGDKSNVEKPGDGLRDFKDIEKQRVFDFLHKMWLNDKSTFISVSDLKIRMGEPFIDDGKLMEILKIMEREDEIIVVQEGYIFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ1</accession>
    <name>A0A4Q9LQQ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1598p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001598">
        <property type="protein sequence ID" value="TBU10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1598p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="454" mass="51739" checksum="281642A6D95F88D5" modified="2019-07-31" version="1">MFFLSLHYNFFLICTNCSNNQRREMYENVLGYSRHSNDRLSIRHEEIRRRQQYSNNIDSYSRNLSGRDNLRLNYNRGENYSRINGNGSAQRTNILLNRRSIHMQDNSSDIIIPMTAIDTNEHTDPVTPENIRQIEFFNSNFTLADLPRPPRQPRPFPVQHTPLPTEPFPVQQTSVQPLTFRSTPFESTPLQIIQFQPTPSSIQQFLRTDTSLQNTQLYPFLLQTPPLQPFSYAQLPSQHFLSPHPLIEPTPYQQFPFILFSFQQMTFHSTPFQAISSQPIPPQPIPPQPIPPQLILPQLILPQPILFQVISSQPIPPQPIPPQLIPPQPIPPQLIPPQPIPPQLITLQPIPFQPISSQPLRPQSIPFQSIQFQSIPFQSIPFQSIPFQSIPFQPISSQPSLSQQLPFQPIPPQPILPQPMSSQPISSSSILSSFSISSPSISSQPISSQPISPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR03</accession>
    <name>A0A4Q9LR03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2089p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002089">
        <property type="protein sequence ID" value="TBU09935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2089p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="16007" checksum="D5DE523CE68A6716" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR91</accession>
    <name>A0A4Q9LR91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1658p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001658">
        <property type="protein sequence ID" value="TBU10596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR91"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1658p0010"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="20478" checksum="0E8144A7C7C23CCB" modified="2019-07-31" version="1">MDKTSADNAAKKRIMKEMQALSKEKSDPKNMAKDTTFRCFEIQPSGNGNFFEWDAKLIPPEGSFYHGGIFNLRITFPADYPFKPPKIIFLTKIYHPNINSNGVICLDILNDSWSPALTIQKVIISLISWLDEPNPKDPLVPEIARTYVNDRELYRQKCKECLELEEEIEVVEIVEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH3</accession>
    <name>A0A4Q9LRH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2010p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002010">
        <property type="protein sequence ID" value="TBU10115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2010p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9183" checksum="431D69F6EB373DA9" modified="2019-07-31" version="1">MNVEVYIQSIVLKKTVETTSFDRRRGLESEMHREPTPSLKEAKREEDGAKNLKPKNKATLISQGGTTLEEPIININEESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL3</accession>
    <name>A0A4Q9LRL3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1345p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001345">
        <property type="protein sequence ID" value="TBU11169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1345p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="16164" checksum="19F7027CE781E786" modified="2019-07-31" version="1">MRRKNFFEPLFENEKFENDKMNITFNLPEGVDPNNVEIKHEKNAYHMKYKTEKKDEKDGVSFSSSSYGYFSRSFPFEIKNPHAEVKENKLFFSFDRGEDTSGLKSIPIKNGNSKEKIVTNKKETDSNASCSSGKCQHCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ1</accession>
    <name>A0A4Q9LRQ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_1572p0010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001572">
        <property type="protein sequence ID" value="TBU10746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRQ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1572p0010"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="845"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU10746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="981" mass="117114" checksum="52C749B64B200569" modified="2019-07-31" version="1">MIWFEASSPYLEKLCSFCENPFPTDKCSYCSVSLHRSCIIEHLKVNNECLIVRTCKYCNVDKRCELELQKNIANSFFNLTNKFKNSDFKNKNEILLENTNFDRKKEFPIEIKKLEIYDAAKQIFTNPLKFYSVISNLQNYKETIIEANKEKNERSEFLSSAKISNILQNFSKNIETAICKKCERFFHSYENKIKKEKNIFDICLDCRYCISCNVFSYENVLLFFLGKYIVFCQNCEIIFKKNEMCNICFKEFKTDDFDIEMMQCDFCHRWIHLDCDARISYDNYLLLSKNSYLCVECTEGLGFDYNKIFIGNISNYDSDSEYDVDCNENIESEDINFKTNEMEKTLILNDQVEENKINSENSIESCNYKDKNYDSIDFYFNIPNLNIFENNLENKKIDFSKAVNFENQLFSFNEDFTEKDKSSILRKYLIYYKNDDLKCLICCRDLRRFSVHQSTRLICIKNSFPNLYVHICCVFYYWLEFRRIKISVTNKKISGIENRCINYKDIFEKTMDLNCEKNSDCELNNNRIKRKYKKKNTQLLEEAFKKDLESENKHTNNLKIIRKRKIKSMESENIFPLEIIYKSIKSFSCVLCKENGANIKCIDCKDGYYHFDCSLNILFIGQSTVPRCRNHFFVQYFEFGKIVCFKNRKEKNETQKDKNIELGSANATEKNEISEQEIGKIKTKRGRKKKKYLIEERNESNKEKHLNMCLRYKNVIYMNDLWCKIFFLQKTKNFLFFDGFSFWINENKVFFPEISYLQTNSEEITIEDLFLLNEDGYKTFLNVKKKRNVGKRSKHECLDFEHQIIKENYLNSNFSKLIYFFSKYFLLKKFNMTLTYFLNFVELEKGYCLKKSQIQGYGLFANRVFLPDEPVIKYIGEMIDVTESNFRESFYGKDRCYMFKYDDDMIIDATMLGGLAKYINHSCDPNCYSTKVVCGDNIYIFICSKRIITVDEELSYDYFFEIDEFNVECQCGSKKCKKYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV4</accession>
    <name>A0A4Q9LRV4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1342p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001342">
        <property type="protein sequence ID" value="TBU11174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1342p0010"/>
    <dbReference type="OrthoDB" id="2193909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="36842" checksum="15A35DB2826DCA22" modified="2019-07-31" version="1" fragment="single">MHLSVIISFCICSANIKTDKKSEKFNLTLVEKQYLDEKENNLDFMIEDPKLLCPRNTSTPKISPATSECSRESSYLDSINRPVKSPKKNIKNIERRRSLRSIPKTNIEPTLISSNDEKSDYDARHPTRNIRKRRFLSIRTPEKFNNRTTRLKENATYNLMDSILRRKEKKTKKAKCLGINFEPMTHGLENKNAMRNATEIPVPITENEIKLLKKNKFASHMFELTHSTPSDTTYYSCKEEDKTTSSEIPKSKTLCYFNESDVLKNKIKEFLYEFMNTLISYYKETNLNNLVVVALQSMRNSDLFSEAECNIYEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS19</accession>
    <name>A0A4Q9LS19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1732p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001732">
        <property type="protein sequence ID" value="TBU10481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1732p0010"/>
    <dbReference type="OrthoDB" id="2195759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="580" mass="68912" checksum="E2B4255F1983641C" modified="2019-07-31" version="1">MSSTPSKTLSHDCFIKIVQKLCNKEYEEAINYILTLQKEYNDGLLEILHAYILTELERYTEAREIPITVPTTKGYYYYITSVFKNLNKTVEFKNYVKIFGKSEEDLYEACILNGDFKGSDEIGIKMLRKSKTFMIFSCLCHIIILKENKQEKMLELLLKDEKVSLEVLYFFIKNDLLTETVQNKLFTFEELNMTYFFILKELFIKGYEINKFIEHGKSINEEIFRKCDTVNVFDFLLDYTDDWKIYQKAINENIILKPRNSLNYKFYNLLNTKSDDIGREIIINSNCFSLILKTCEILNFKKIQDLPRVYEIFIENIKNIETEKLTDDINNFTIIKEMFDIYTKEKSLINIKILLSLLIGSRNEKMLILALYVSFIHKDTFETNYEIKLIYMFICRFFCFYSEVTKMFKELSIRNIQHENLCFLWSDLNIILNLNDKNMEKKYKNFYFDTQKNFNNAVMPYLIKQKYHFAIELLEMKKSFDDSLVFKEVEKNQILAENSKTMFSDILGYKCEYLFSKMTINSRENKFIGFSLGTIYNPKISGENGINLLDNGVVELGEDGVFIELVKDIYKYQETIFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSA7</accession>
    <name>A0A4Q9LSA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1790p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001790">
        <property type="protein sequence ID" value="TBU10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1790p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="18189" checksum="77F8D4EAFAA82DEB" modified="2019-07-31" version="1">MKIIGHEYNRQHTEILKYLTQIMSHFVLEILNMGHMKIRDDTRIKTDIKYGNTLRILAKYHKRYFKTPKILMNTVEIISFDRRRELESGPNAEEIWVKVLMGVIKRAEIHEEPMPPLKAASNYEDDVKEKKTKNNAPLFQKKEPTINKVNIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ0</accession>
    <name>A0A4Q9LSZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1298p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001298">
        <property type="protein sequence ID" value="TBU11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1298p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24408" checksum="979BC4AC523B73BA" modified="2019-07-31" version="1">MSDSFSGKNTHEKKYHFYVDETPECIECENDLLVLEKYLSNNDQERIFANTFEGHSMLAMASMLRINYRRLINGSTATFNVDVSPSTIDRALRETNYATSFRELEVDNDDKNFVFLDEFGVAVVIHLSESAYLSVTPARSRIYHKIHERAINEEDFRLSIKISTSIFVIYNARIHHYLGLNDDEEIASYQIKYLPPYSQFFNLIENAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT30</accession>
    <name>A0A4Q9LT30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1599p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001599">
        <property type="protein sequence ID" value="TBU10700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT30"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1599p0020"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020715324" evidence="4">
        <location>
            <begin position="16"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="707" mass="80058" checksum="5A06CC363124DF85" modified="2019-07-31" version="1">MKLLFLLSFIFSLENKNDNKAVAVGIDLGTTYSCVCVFDPVANKPTIITFPNGKQTTPSVLRFEQFEVDGKKTALPVTGWNAFYENQKKPNKSNYLYAFKRYMGLSKADEKKILEYKHLVSYEMELIKSGDGSSVMMYTKDENNNIIKKVTPVDASRYILEGLKRHISESFDNVGKVVVTTPAYFTTNQIEATAKSAALAGFRTEYNCAEPVAAAYAYQMTKSGDKLENYLVFDFGGGTLDISVLEYEDKLLEVKTYSGDNYLGGEDVNDCIFSHFKDILKKKGVKFTDVNDELRLRAFVEDFKLSLCDKQNKSDEKDFKGVDCSHKDDFFYEGDKFVSLSLKTSEFNKICQRVFDKVTKYLSETDSEGILYKYKKDENGSSSNISKVLLVGGSSRIPKVRWILADIFGKRKIDHSLNADTVVAEGACWYAAYLSKYIAKDDLIQLADVLPMGIGICVDEDIFVPLLKRNTTIPSNGTKVFTTAVDNQPAVSIKVAQGERTSFKGNHQLGSFVLNLPFQAPRGVPQIEVTVRIDTNRTIHVFAKELSKNVEAQIKFDKHDYSLNEETIAKMLKEKEENEHLDKEVYDRYMAKNELVSYIDSVKSRMNGLSESVKNNVESAIVNVETWLEAEKNSADKEMFREKMETLKGVVEPMLSDKGVPKGEMESMESGKEMGREEDMDIGYSDRIYIGYRVRIWDIGLGYRYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC1</accession>
    <name>A0A4Q9LTC1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1228p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001228">
        <property type="protein sequence ID" value="TBU11396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1228p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1594" mass="186491" checksum="961DC40700995AE1" modified="2019-07-31" version="1">MMCEAILKSINIKTYFTVLSLYILSISKVILTQKTIALHFYEAEEIQLTENGTKNCDYFDECFYFDDQKPILYSFDSNSKVLQVFIINLETFCLNFSNEEEIQENQQHNIYININLVNYKEFLYFYNTVMCLPFLIENVNENRYQLMVKICDILKIKTNKRFEEFIRLMLVSLIFNPEVKNKWKFISNSKNYQCSSIVSKKIIVEYFKMHFIPEKTQKKIKDISRALYLTDGFSFDFIKLTDDFLYLDDDIINEILEKVKKSNDDLKIFDYIFCIHKFNCIFLSEISYADGYDQLFNLSLFKNLNEIFIYRCLNADVLIQKIYNSCGSRCIKTLNIIHSDFTMKYEIPWLRKLDFKAVNYIVGKDGHRTIFKNLDFGSLVPNIFSRYIDEIYEENKSNIFVRTGEVSCYDQDKKFFAQFYQERSKLENFTNTKSSIQTYIYTELINAFLSFIFYIINFSELKNIKIHLSNTCIKDFNIRESEILNNITKMIIVDSTFDAIFLSKILMFPSLKDVYFNRCCVKFLKNEVVFNVNKTIEKLYLGNFSVDDQYHYVKFINYILNLKILDINIYSSSRNSNIFSIETDTFDIKLFHLRSLKYSATAFSDFAEPIFPKLPYILQIELGSNFPKGTLHRIFYRNYFGSLKRLKFDRANLGKEDEFAFGNYINLLSLCFSRNSKCLEINFCKLFNSNNIYSLQELKLPDIEITCLDLQFLSKLNCLKKIYIYSLASQAHIINFFKLLLFVQEIEIEKLSVYGNEIYEQFGTKPAHLIWMNDYENLKYLSRCPARFCTPSSCPDSSACRPANTMENRNAPAIPEGNRLMQEWPRSTISAVQKRFERMPRNSWPVTLRYYNEKFGCTLDIDAFKKLAQNEAEREIRQEENGERCRIATCLNEPCTLTDTTEYINLRDKFLSKIKEISEKEIGKVVVRTRKLSSELVDSKVLDLVNRIIGYSEFHVPKNVSDASPIIQAAQENIESKISKLVLSKDLLEKAHKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVEKNECLNVYEKKITMHERGSDSERRIVCLSFPKLNLSWHVVSRDEIVSFWSTMWNKNDDQSPAGIDGIYNFFIKKLTSLHKYLYDIVKVICLEGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCATKTSWEQYEQALLNIAWNKDYGNNLKATWIDIDRGILQGDSLSPLLFVLLTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVGVYKYLGIIEDSRGIPTRSSFEEVRCELISRLDDAVRAVLVKNKIHHRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENSNKTHLALIKGFLKVKYRLVIEVPKKSVEEAQLAKLYNEIKRKLHSKLYNARKNELVSVSDSLRWLKRGNIRPRNKAVFCYIQDINVFWRANGMCQHCNESGKTVDHLANRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSLKRIRSHSVQETLNNEYVEIKVDTRIKTDVKIQCNEPEIYILDNRRNKITHIEVIIPYVMTWDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN1</accession>
    <name>A0A4Q9LTN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1092p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001092">
        <property type="protein sequence ID" value="TBU11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1092p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="14801" checksum="3BAD642046B5C315" modified="2019-07-31" version="1">MIIERADRNIQTAPLFKGVKNEKDSVKQVNTKNIFPFLSDSVTTVKPLKIHEERRASMGVIMRSEMHEEPISPLKEAKTEEVCAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVGKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS6</accession>
    <name>A0A4Q9LTS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0928p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000928">
        <property type="protein sequence ID" value="TBU12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0928p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="288" mass="34620" checksum="70AFB784F0374B49" modified="2019-07-31" version="1" fragment="single">INNRIKKISNDENIVCSLCKSKFQEDHAWVSYKEKYFYYLINDNLIIKGFSTFKLQENFYYIFGLISRKYNGYPFLNILNFHCISSTEINERIRSNDLFEELSKRVFKNVSCFENAKKLMLILGFVNFKSSKIIIYCDDILSMERLCKMVFSFFKWEIPVIFEIKNAFNDSSFVIIQKYKKKRNKLLNFDSFYIPNKKIIFDYSYEKNDIRKVFLKTFNSNFGDLLEENQDIFLRLRRHFKNKVKPSKILELINDLLISIQFLSQKEIIKKEELILIGNFIEDTFLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM6</accession>
    <name>A0A4Q9LUM6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI37_0544p0040</name>
        <name evidence="15" type="ORF">CWI38_0790p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FI-OER-3-3</strain>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PITJ01000544">
        <property type="protein sequence ID" value="TBU02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000790">
        <property type="protein sequence ID" value="TBU12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0544p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0790p0020"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000215">
        <property type="entry name" value="Cyclin-dependent kinase 2 (CDK2L)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="295" mass="33998" checksum="99F6072EFB9AE9E9" modified="2019-07-31" version="1">MVDYQKIEKIGEGTYGVVYKAKDKNTGEIVALKKIRFENENDGVPSTTIREISILKTLKHSTIITLLDVIYTNSRLYLVFEYLDLDLRKYLDMIGSQNKTLSDAQLKKCVQQLITSVHFCHSRGVLHRDLKPQNILVDKNGNLKLADFGLGRIAGIPLRTYTHDIVTLWYRSPELLLGCKHYSFTVDIWSMGCIIAEMFLLKPLFPGDCEIDQLYKIFRVFGTPNDSVWPNVTRFKNFQAEFPNWEGVPFEELVPAIDDFIDLLLKMLVYHPIKRITAKEALKCKFLEGIPPIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS1</accession>
    <name>A0A4Q9LUS1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1246p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001246">
        <property type="protein sequence ID" value="TBU11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1246p0030"/>
    <dbReference type="OrthoDB" id="2191713at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="25035" checksum="3BFA332604DEF50A" modified="2019-07-31" version="1" fragment="single">GITSKNGNIAILDKKENDIQQSICSEHILLSDFVSRNYYEILSIPNVNRKNIFYVFKDIVRGLSYLHSNGIVHRDIKPANILFYNRNGNFIVKICDFGHMKLVDEVIEEYDSGYGCKESGMYTKASFSSDIYSAALVYFEMLWPMKTVMEKDITIRRMKEYEQVPEEFKSLFKEESYIIEKCLKYNSKQILTCRELMRLLLNYEKIFFGKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV4</accession>
    <name>A0A4Q9LUV4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase</fullName>
            <shortName evidence="5">UDG</shortName>
            <ecNumber evidence="5">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNG1</name>
        <name evidence="8" type="ORF">CWI38_0786p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000786">
        <property type="protein sequence ID" value="TBU12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0786p0020"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="7">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="31986" checksum="D1D49D9808324790" modified="2019-07-31" version="1">MTKELLNNSDEIDRKKNCSHTCKICKLKDYISEDWRKYFESESIDEILCSIIKRLHSTQFYPSIEDIFRFTHFFPLEETKVVIIGQDPYHNQGEATGLAFSVPDTHKKLPPSLRNILKEVSSNFPNEVNINMRNTLNKYFKSKENKEKINHKINSSVDKPLNGCLIRWLQQNVLLLNSTLTVAPNKPNSHFGYNWHIITDNLINKISENCANVVFMLWGNYAIKKEILIDCKRHLILKSSHPSPFSADISFFGSMQFKKANEYLIQNNKKEIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV8</accession>
    <name>A0A4Q9LUV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0753p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000753">
        <property type="protein sequence ID" value="TBU12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0753p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="48941" checksum="FBECB70056443441" modified="2019-07-31" version="1" fragment="single">LINYHIGVLRLEPAGFSKLDDAVRAVLVKNKIHIRPECKERFVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKLKYRLVEEVTKKILEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQRFNKSGKTVDYLATRCEKMLGHDYTRRHNEVVRCLHLFLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVNTRIKTDVKIRNNRLDIYILDKKKNMITLIEVGITSQDSLQIVETEKLSKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHRLHLKRLEIPMNIEAHKTVETISFDRRRGLESGLNAEESWERASMGLTNTPFKRSEERGRLRTTLQESTNNINEESDLEEETVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW5</accession>
    <name>A0A4Q9LUW5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0748p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000748">
        <property type="protein sequence ID" value="TBU12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0748p0010"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="291" mass="34372" checksum="CB44E6C5AA76C77B" modified="2019-07-31" version="1" fragment="single">MVYGKTDLVRIFCCLKFIVCYLTLEDLPSQYLNIKHGNFSRRYILETELGKGAYGTVFLASSESTSKNFAIKVQRIDFYNIFKYSPDIQFTTILRHENIVEIFEFKIIQDLEYAIYEYIPLTFCDFFRTHSVEFETFIYFIKQILDALNYLRIKKIVYLDLKDNNIMITKDFTCKIIDFGIATFEESQNNIFKCADTSIDDVNDTRYSFYAPEIRACKKFNHKADIWSLGQIFEEYFEGYKETIKSKEYKLIVADFISKTLDPSPKNRISADKALLHPIFNILYDFVFCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUW7</accession>
    <name>A0A4Q9LUW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0749p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000749">
        <property type="protein sequence ID" value="TBU12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0749p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="12600" checksum="A5200A315D386B9A" modified="2019-07-31" version="1">MFYRRSLNQVNSYEFPPSDPFGNYLQNRFMSFASQYEIPQILANSPLAQLKPFKGLIDKIPTNQGIIEAEVVDLGVLDVLPVIADALSEKERNIKCIGTAKDILICLKNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV15</accession>
    <name>A0A4Q9LV15_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1204p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001204">
        <property type="protein sequence ID" value="TBU11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV15"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV15"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1204p0010"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="575" mass="67417" checksum="DF2E1E189BF10338" modified="2019-07-31" version="1">MQNNTHISKKIYTTDTDTKNINMQNNTHISKKIYTTDTDVLTIKLFKNYLTITILNTETRHTYNEYTKKLINCINLNKLHPDLFDLLKPGSDHCIVDIYDMRDGRNFKVILKPDPTLISNESVHLDLNPSTKIFQEYKLKEYNLKKYDFIKFKENKNKDLFKLICGINELRRVYKNFPNEVFGGNRKDLVIKDSKLYRTLKFKGHGWFFSMNAFLFSKYFEVIFRKGREIDTHKNGTMIKSKFATIKQVNDLFEQTKINYKKNITDFEIIVEFTDIQMAKELISPPNVRFSPQQTPKIMSNHTTPILRNNDFQSPKGHINYGLQDLRESRYYTSPYVQKGHQTFTNMQSVRQLSANQNLKSSATNNSEGPTIPQPNMPQTRQISANSNFKNMETINYERLTIPQPNMPPTRQISTNQHFKALDTNIPERPIIPQSNVPLNRQIPVNQNFKSLETINYERSTIPQPNMSQNRQIPANQNFKSLETINYERSTIPQPNMSQTRQIPANQNFKSSIKINMEKPTIPQQIFKNQTQPLKDENLDDKKQKLNRNQNPNPPNSNPRTIDGFFFDWKNNTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV40</accession>
    <name>A0A4Q9LV40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0377p0020</name>
        <name evidence="2" type="ORF">CWI38_0754p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000754">
        <property type="protein sequence ID" value="TBU12444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000377">
        <property type="protein sequence ID" value="TBU13627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0377p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0754p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9385" checksum="910F16B142169B44" modified="2019-07-31" version="1">MKEDKTIASEKKINSPNISEIPHLNVNKPIEIKDDNLEDPNCKNTDFFHHILNRRYEHQNGPMQLSEYEHKNKSKKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV44</accession>
    <name>A0A4Q9LV44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0831p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000831">
        <property type="protein sequence ID" value="TBU12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0831p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="399" mass="47180" checksum="335FA47AA604B73A" modified="2019-07-31" version="1">MILNRDNECFIETNQYGIFEILNSLVRKRNILKLEYFHPLVKYHYKITLKNIFEYQNEIEDICDTIKMHVERLSSSGNYGIGFSYNLLKHFRYCVLSIFYSNDLSIVYLKPIYLLITIWIEGVIQKDISLAKNLFYISWSLKVMKATMEYNYECLKPFMNKDVETDEQGAFSSLFCIDNDGIHKFSRLVVDIGKNIFEILDKKIICKIFETTADMIVWPSHSDSIFSTRYTPPGMPGILFDVFLFLSEENLNVLNSMICDYKEMKQNSENIDLEFKLYMKNRLNLKNYSTNVKVRNIYYDLACIYEEIFLHKFFFYNCVKKSNFSNLDLWIHTNILNLKQKIANNIVPNYDDYIGFLETCNLFLHYISKVVLNPGLTPIRYADIISKKIISSLEVNHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV77</accession>
    <name>A0A4Q9LV77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-actinin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1152p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001152">
        <property type="protein sequence ID" value="TBU11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV77"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1152p0020"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="573" mass="67311" checksum="C72472D512CAFA6D" modified="2019-07-31" version="1">MVINTEEQDWKKIQTKTFTKWINTKLNEGSYPTVTNIFENIRDGTVLAHLLFILTEEKFIYNKRPITRFQKVENIQQVLNFIKQKNITLINIGSPDIVDGNEKLILGLIWTIILRFVVTEGVQSDSSAKSALLSWCRACTASYKNVDIVDFSKSWQDGLGFNAIIHKFTPELIGDYNQLSKKNKIENLRKAFDTAENKLGIPKLFDPEDIAHSIKPDEKSIFTYVSQYYKKFSEMEKMDSAKKRLSDFLSIVNNSIKIKNEYEMEAKKFIELKNEFENNYSEIENLIETLNIKLGVRRTLSNEMNHKYLLLNSLLGNINTINNFYKIKKYEPRDEYKLDFLQKNILNPTYKSYKSYSSLMKEFEILDNQNMEYIKTLPSKFRSEEDIESQLKAVKNSLEEIDSILKQTFNNKSIDNISLNEFETKKSLEFSKQIFLEKYEILKIISIKRTEHTNLLNEATMMFKKIDRQKTGKINIIDFHHCAKVLGLITEDKDICLEKDTLLTLEEFLKCITFLYDQTFSLDRITKNIKIKNNQDFYSPENKIENIHIDELKEMIDFNLSLENGDIRKVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV81</accession>
    <name>A0A4Q9LV81_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0704p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000704">
        <property type="protein sequence ID" value="TBU12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0704p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23321" checksum="E8E0FD8ABDD62091" modified="2019-07-31" version="1" fragment="single">TDVKIRNNRPDIFILDKKKNKITLIEVGIISQDSLQIVETEKLRKYDLLANELGFIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPINNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB1</accession>
    <name>A0A4Q9LVB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0806p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000806">
        <property type="protein sequence ID" value="TBU12317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0806p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="23032" checksum="DAB906C3344F3E9D" modified="2019-07-31" version="1">MDRLKFCLSKVNLANKGDLLFDDLYDYVHIDEKDNDKKKCGICYSSHCINMIIDTVIPAIKSKFPPAYKKKTIYIQQNNTKPHFSDNDADIVALGSADDRNIKFKVQLANSLDLNVLDLASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLTDDGNCYKILHLSKGKLRREGRLLEKYVFSKEAYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD7</accession>
    <name>A0A4Q9LVD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0683p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000683">
        <property type="protein sequence ID" value="TBU12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0683p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="23780" checksum="8D63094152BB587D" modified="2019-07-31" version="1">MKNILCSFFLFVFFGINNCIRINIFFNGIDRSFDSTINLYDFNDLHNLIGRKRILETETTFIEPNNHSFRPNKNRYLEHNQSKESSVRNKKPRLDIDSENKTNITPKYFHTNVKCNMGGDLDQINVEKSSFEVSNERIKNYGHLKTTQIRPFKRTMDYITIDYSNIFIIRSRCFDILHRSKLRETNINIKDITKSNIDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE2</accession>
    <name>A0A4Q9LVE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0679p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000679">
        <property type="protein sequence ID" value="TBU12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0679p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="379" mass="43938" checksum="CCCFB1673DD63FE2" modified="2019-07-31" version="1">MKAADQSGCLSSANYSLVEAAENSNKSNTNNSPWSKSCLGAFGEIREYFKSLGSKKSDARPKESSLPPIQFSEDVVSKPIVSYKDVSQSDLPRIENFLNNHYFLAKFFKNNTEINYKKFIKNICCIEQKSMETQPGFSDSNQEIFERELGGIKSMFSPTYVSKKCYISVFLAIKSIESILLLTDMRLRNDEIKSMRIDHTFSLKDRINNVLDNNLNLIVEIIIVVCSFGLNMEDDFLKILNILNIGIRNWGFGSIDSKFNSPEISDTNFITDLVFSFDTNEIKKITNTYNSTETIKDTNEKEIVIQVIKYYLIYFLILEKEQYISLETQFRKIIPREDQNSEIFFQDLRKLRFETYHLFHSVFNPCCNRLLHDSEDQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT1</accession>
    <name>A0A4Q9LVT1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0610p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000610">
        <property type="protein sequence ID" value="TBU12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0610p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26543" checksum="CBB31D50BCEF776D" modified="2019-07-31" version="1" fragment="single">NLNEQQFYDTLRTLKIKGTPLTHLEIEKILNFSRLENLKLHTCNLDSSHLLNLNKLISKKILRRLILTNNKIKNIPITCKGMFNDLEHIVLDRCGLYAGSVSLFFNDTKSNKISFLDLSHNSLNRTDLIVVSGLIKLQVLKLNGINLQEDARLNNLTTHGLTKHLKFLEIKELTISAKDILFLSKFKVLEKISLSESSFKCLKNTKVRICCSNFDVYSVLEIETLSNKEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY4</accession>
    <name>A0A4Q9LVY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0718p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000718">
        <property type="protein sequence ID" value="TBU12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0718p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="50691" checksum="914AEFDF7F560B0A" modified="2019-07-31" version="1">MYFTKCISNDNFILMTFLFILCSNSSILIEENGKSSEIKTIPETQESKHDTIKPGKLDDSSDSVSTYLNINISKNQQRRNSTNFFRLRKLPNMNFSLYNGKEEQDTETEPMQTIKIPGMHFQEGNFSSLPDSISPPSIDIPKCSMEEVANNIINYSEKSKLPEILILLEDGYLIKNHISTLGTKKYFLILKNLIKIENKILELNAEKKQDFEDHFQKNIENSDLSAPQGSILLQLPVFIAIKKTIEERINLAKSDIKNYVTVFFGLQGIERYIKYTDKEVKKILNAPTATDSCNTSDVFLKYLELFSEAKTLIGEKSESVSSGAINNISDKISPVLLAVMFYFDEKEIKEIYALYGSFNTSSSSDSKFLNKKEQEKTIFSNHLIFKIIKYYFDIFDTLYMKKPFKFSSFASNQTKYESLKKRFDRLSKDEAYFKKNILIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC1</accession>
    <name>A0A4Q9LWC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0213p0030</name>
        <name evidence="2" type="ORF">CWI38_0551p0030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000551">
        <property type="protein sequence ID" value="TBU13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000213">
        <property type="protein sequence ID" value="TBU19301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0213p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0551p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="68" mass="7668" checksum="7EC8DC8A1066AA22" modified="2019-07-31" version="1">MGVIISAEMHEEPIPPLNEAKKEEDGVKILKLKNNTPLISQRGTTLEEPTNNINEESDLEEETIVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ3</accession>
    <name>A0A4Q9LWQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0510p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000510">
        <property type="protein sequence ID" value="TBU13178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0510p0050"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="31816" checksum="0C8E9E6C22ED28C0" modified="2019-07-31" version="1">MYLQKKNVFGVAIIVLYQIIFLYSVNCTNISLPNPVDLDVNGVSDKYKPIKLLGEGAQGKVYLAENMRTKEKYALKIQKIQLSAFFHTVSLFKKYLKHENIVKFYASNKDKTYEYLLFEYLPITLFAHLKKCKETVGNFMLIMKQMLDVLNFLQNQKIIFMDFKFDNVMLEDDLKVKVIDFGMAVVTSEDTDYSYLPKIDLKKNPEAAYLAPERRNREKYGCNSDVYSFGYCSKMYMNNILSQNDSFSRDGNDFFKKCLEDDPEKRITADLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU1</accession>
    <name>A0A4Q9LWU1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0886p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000886">
        <property type="protein sequence ID" value="TBU12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWU1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0886p0010"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF15">
        <property type="entry name" value="OS01G0568000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111664" checksum="103050359E741D2D" modified="2019-07-31" version="1" fragment="single">MSLKCQLCSYISPTKNSLLIHYKSHDITPCYLCIYNRKEFPYEYPLYYIRSKGIGSIGGVSSKVSSLKGFSSKVSSLKGYSSSLEGVNVIGSGLKGVRDSIKGVSDKGEFEGVNNSIDDYKGVNNSIDDYKGVNNRIHKQRGVNNNSNQQQGVNNSIDDYKGVNNSIDEQRGVNNNTNEQQGFNNLYYKQQGVNNNIDEQRGVNTNTNEQQGVNKSPYNYHPLTPTTLTNTPITSHIISHPKCLFCKKYFYDTSKILNHMTHYHYLCTLCDRMGKKHQYYNTYDTLQLHYSTNHYTCKYKECIDSSCYVFCYKVEMYEHVVNYHNENIRYQDIRSIDNNSRLEGNGYVSGGEYVSGLEGVRDTGLEGFRDTGLEGFRDTGLEGVRDSNILEGVRDTGLEGVSDSNILEGVSNSIGRLEGFRDTGLEGVSDSTHTYRGVISTTDTYRGVITTNNTYSDSTDNTPNTLIIPFINSSAYANEQGYGRVTIGSNVLRITRSNTNRKITINKIEKDRTEDTINNTSYDSISSSNKDSSSRGNSNNTLINNSNKTLINNTPSIIPINNTYHNSNIINTPSNIPSNNTIPSYMDRTQSFIRNTNNINTYINKYYNIHNIYLSEQITLLHLNEISVEECCERICKKLGEKEFIRFFEGVICYIKDDVKGCVLKYVSCIKDRVLFPRFSNLKGVNNRGMLEGVNNRGMLEGVNNKVSNIKGVSTSSRDSSLKGFNNKVGDYNGVNNQVSDIKGVSTATRDSSLKGFNISSNRQQGVSTATRDSSLKGFNISRDIKGVNTSGKDSSLKGFNLSSNIKGVSNSSSNIKGVSNSTYKQQGVNNIKDVQQGLNHLSNKQQGLSNSKDVQKGLNNSIDVQQGVNNSIDVQQGLSNSKDVQKGLNNSIDVQQGLNHLSNKQQGLSNSKDVQKGLNNSIDVQQGVNNSIDVQQGLSNSKDVQKGLNNSIDVQQGLNHLSNKQQGLSNSKDVQKGLNNSIDVQQGVNNSIDVQQGLSNSKDVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX82</accession>
    <name>A0A4Q9LX82_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0812p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="PITK01000812">
        <property type="protein sequence ID" value="TBU12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX82"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0812p0020"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="55772" checksum="258A35698BFFD540" modified="2019-07-31" version="1">MKIAYMFSKQVGLHHYGQGHPMKPHRITLTHSLVHSYNLDKYLDVIIPTQLTLGSYHNPEYLRDIKRSDEICNVEYDSNKGSVVGLEGDNDRVYDYKGVNNSTNEQQGVNKSTNEQQGVNDSINEQQGVNDTTNNYHPFNNSTNTYHPFSNSTDTNTTNNTPCYGDDCPLFPNLYDFCTHYTSASLLCARLLNSNTYKTTINWSGGFHHARKNEPSGFCYVNDIVIAIQELLKCYERVLYVDIDIHHGDGVEEAFMHCDRVLTFSLHKYGDNYFPGTGGLYSPGSINRGCSRVESKGCYTTDLINNTPLTTSTNTNTPLFTSSVNNTSYTTNHTNNTPFSYIVNVPLRTGIDDPSYMYIYEPILKSIIRKYNPSCIVMQCGADSIMGDRLGCFNLSVKGHGECIKMIYNLNLPTIFLGGGGYKMKNVSKCWTYETGLLLGVDMCNDIPKNDRYYEYYGSDYTLHGGLVKKYDNMNSKGYLDSVMGYILKEVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXS4</accession>
    <name>A0A4Q9LXS4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0407p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000407">
        <property type="protein sequence ID" value="TBU13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXS4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0407p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12724" checksum="5FE4962A70422758" modified="2019-07-31" version="1">MKSRIETSLIFQDHLSKINEFIFYEKTASIEKYEVPEIRKIENVHIIEDIINNIKNVYQQSSLEDAIRCNTNIPERNKDLYLKLLKKDNFKDKIKIFEFLILYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX4</accession>
    <name>A0A4Q9LXX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0709p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000709">
        <property type="protein sequence ID" value="TBU12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0709p0020"/>
    <dbReference type="OrthoDB" id="2195427at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29142" checksum="26ABF9B441C2CCB1" modified="2019-07-31" version="1">MLIFLFIPGFLFIKFRLKRLNHPEYIGVYEKTPGLVKKKDALHFHLEKQGTHKVGLCSSAGCLTEKNSAAIFGPNGTAVLMIRNDDGTVTFMLNDKCLAADRTGLAFLKCGEYDKFEKITDKLLRIKGNNHTKSDELHDRKIEKEHISNPSETNHHHHHHHSNMSENPELIERTEKEHLKHLGKHKSDPNYTTDQDTARHHNSHVHLVGETSNRAFYTFYSYHPSDRHSTWAFHAYHHGIPLRWADEKTRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY30</accession>
    <name>A0A4Q9LY30_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0689p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000689">
        <property type="protein sequence ID" value="TBU12625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY30"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0689p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="98999" checksum="8DA22F31268E7F61" modified="2019-07-31" version="1">MYTCQSKENHKNVEELVEEMNKNPFILFISTLYLENIIQKRKTVFNSYIDNTILEEREVMKKEKTIFKDYIDNIICEEKGETREEKIFFIFENEIIKYFTFLNPNYYNEWVDIFKYRIFYEIYCCFLSVFDGMEMKFNEHKFFLERMKVYVRNSGFYSVESILSCNKSIIVSENDYISEFIDITMKMNNNLPQKENNQIKTSILPNLLDKGLYDGILLEEKKNDRNLQEEKSYEEKLQDEKFQDTNLNEAESQEKDVLADNSLSKNHRNTFHMKLNDSLREMEITNLRKLIELYTGHIQYILDQLKSHAYIGSKTDQKESEICEIKCTKDFHFNYCTCKLNKKRKQVSTACNTFSSISKKTKRKESTHETLENELSNRNTDKICLKNEGNFPLYEKELLDRNTSGIFCKDKGGIPLNEKELFENKSTNRNKAINRFKNTKSTKNRIPLDIFQSIQLDLKKYFGKIFDSNEQKIKRFSFLKIYFESKLYKLYNILLRESLTEDMKKIIFKSIYFLFYKTYTEVIRNSIDNIKSLELKNFKSTNCENIYSYFEQILKMDEFLIGSEKATGFIPLNSLIILSINYNQIVLIFDLDNTLFPTDEIEKNGVSLNNTDIYSIGDSLRKYFLESNSSNDKYTGSINDPESLIMRKNDSVNKASICSIIDKNVSLDNLKMENNLSFNGTSASSIITTEESFEELKMKNEHFIDQKQLPFLKITQHIIYKERLKIFLTNLPGKKICFTNSRKHHASYILTLLNILDCFDIIVHRGDIEDTKYIKPGVQSYIFMEKLLGVPPNLIYFYDDDYINYMMAKQRKWNSFLIKDSLEQVVTESLESYNGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY82</accession>
    <name>A0A4Q9LY82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0314p0010</name>
        <name evidence="2" type="ORF">CWI38_0335p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000335">
        <property type="protein sequence ID" value="TBU13806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000314">
        <property type="protein sequence ID" value="TBU15246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0314p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0335p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="46531" checksum="04F93D6A8AFBDDD1" modified="2019-07-31" version="1" fragment="single">DTATFLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLNCLEKSKEISTRRAAILKYRLVEELYNARKNELVSFSDFSRWLKRGNIRPRNEVVFCYIQDRNVFWGADGMYHLATRYEKMLGHDYTRRHNEVIRCLHLLLLNRYKFKSSKRIRSHSVQGILNNEYAEIRVDTRIKTDYDLLANELEIIPYVMTWDGIVTKYHKSHLKRPEKPMNVEAYIQSISGLNAEESLERASMGVIIGAEMHKQPTPLLKEEKREEDGAKTFKLKNKAPLISQGGTTLEEPNNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY90</accession>
    <name>A0A4Q9LY90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0329p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000329">
        <property type="protein sequence ID" value="TBU14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0329p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="50141" checksum="903FC5B190AB1678" modified="2019-07-31" version="1">MRNKNDDTVTYNDYLIPFVSDNHPTMFSSLNEFLNINCQSLECLTSTMLTTNYVTKVVDLEGEKPKVACRKSIKVVRVLSSMSLNEEYDIIRMRPGNNSKQEKSYTKRLNKDTARKESVTIVVCVVYGFVEPHPKLEIDNDADFNTHNHLLFIEKFKLLGIDSFTWTIIEDSRGIPTRSSFMNERYFHTKFNAINLFSAINQHAISLINYHIRVIRLEPPDFSKLDDALYELHVKNNVHAFPEEECQIVLILLRIHASVSFGLPRKSKEISTRQAAILNVENTNKTHLALIKDFLKVKFRLEEEDRSVFRGADRLCQHRVKSSKILDHLVTRCEKTLGLEHKRRHNEKPSFSSRNFENEMLSRFLQQEENTIIIPKRLEMTINEKATTQYIVLKKTFLEGMSICVIKRAKIEETSKLPSLQASNRKTVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF7</accession>
    <name>A0A4Q9LYF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0330p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000330">
        <property type="protein sequence ID" value="TBU14198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0330p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="774" mass="92818" checksum="0A70DA1E7F9D2C9B" modified="2019-07-31" version="1">MKFLRTMRGCILNVTYTKYNVHCGIFFILYINRIIFAQKTIAIHFYENIEGSLLENKVNNNKNSNTSSNFPNINYISGKYNLKNKDFQVFIIELDTFLLKFLNEEEIIEGHQNSIYINKSSISYEDFLYFYNIVMCFPYLIDFMDECKYLKILRIINIFKFKYDKSFEEFIRLILVSLMINIKPTSKLNGLLKANIYSFPGYLSKRIIVQLFKLYLFSKKTLNKIKDISIAMTLTKYYNLDFINLNEDYLYLDNYIIDQILEKYLKIDNFSKIIHIIFSIHHFRSIFMYKISYLSRFNTFFDLCLFNNLDEIFFFECFQTDFLIQKIYTLDIATNPKILTIIHCKFTIKDEISFLRNLKVKILNYDATKHELISIFMNLGVESLFQNFFSRFEIEIYNKENQSWILGRDTNLPCIDWHTEMNIIFYQELSIIEKLKIIEFPFNAFIYVELTNPLISFEFYTINLKDLKNITIIFTDTYIKDFNLLDTDLFSNIIHMRLVRSTITDIFLAKILLFPSLKSLFIHDCSIIFNDREITFSENTKIEKLYYRVSLIDNKDYFLKYIFKMIALKNLEISCNLKDKNSLFSKLDCMNSSFINLTQLKYSVKHYFTDSLPKFSIFRNLSEFNFGFEYPEGTVYKIFHDQPFVNLKKMIFNGIKIGKNDYLALEKYTNLTHIYFSLSCKIKVISFSEIFDCKLKYSLQELRLPDIEFNYCDFLFFSKLKSLKKVYFYSFRVKIDIIYFLKAFSSVAEIDIEKFLEYKTLIHEEFGLRFSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK8</accession>
    <name>A0A4Q9LYK8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0423p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000423">
        <property type="protein sequence ID" value="TBU13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0423p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="29783" checksum="512BA8EA57359363" modified="2019-07-31" version="1">MKFEEARLKNLLNKIVHNAFQNYKIQEKEIFTCDSNYSGRLKKENIKPNDEGIFFYAHDRNVFWRAEEIFQFRNQSNKTARRDNKNIGFLYLLLLNSIPKNSVSRMEFNDEIRNITDFLVSAQDKKYIALMKHSIQGNEPYEELIHIETNNRQRDRVRQKIPSNMTSNEKNMIELAKYGGKDAPEERSEKYIGESSINIYENVKEKKNPQKTHNNTTNTNEEKRISKVTLNYYETPKTNLFSKIQNKFSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ7</accession>
    <name>A0A4Q9LYQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0407p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000407">
        <property type="protein sequence ID" value="TBU13516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0407p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="21654" checksum="206939158642619B" modified="2019-07-31" version="1">MKNEIIKLFVYIRTSIPEEILSLFDIFLNLKSIEIYNFPHKIAKTSFSELIVLKFIDKLILQKCRITEDFINLFVKNCKYIDIKNTLFYESGNEIEEFNIIHDFEDNHINVLLLLQLLDNLKCFAIPGKNISKILFTNELRSFLSNKTLENFAINSIESSSVKTVFFIACKIVEKFHFGSGFSPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS7</accession>
    <name>A0A4Q9LYS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0275p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000275">
        <property type="protein sequence ID" value="TBU17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0275p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21180" checksum="347572B7EB0891AD" modified="2019-07-31" version="1">MIYIFCLPLFFLNSYNFKSSKRIRNQSVQEILDNEYAELRVDTRIKTDIILIELGITSQYSLQIVETEKLRKYDLLANELGLIYKCNGIVTKYHKSHLKRLEIPMNKTVEIISFDRRRGLESRLNAEESYERASMGVEDGAKNFKPKNKAPIISQGGTTLEEPTNNINEESDLGRRNGSDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ46</accession>
    <name>A0A4Q9LZ46_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0365p0040</name>
        <name evidence="1" type="ORF">CWI38_0632p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000632">
        <property type="protein sequence ID" value="TBU12780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000365">
        <property type="protein sequence ID" value="TBU13676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0365p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0632p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25242" checksum="A5DF4D1F7B52BD04" modified="2019-07-31" version="1">MRNTLHSFTKKLNLSRCRLDSCIVNFLSKFKKLETLKLCNLPPFAKILSEKFLSSNIALRSLDFSSSESLQNDMIFLSQFKFLKKLKLQKCNLKPGFMEYISTDSLYLSLKKLVIFGNQFEINDLLILSRFKNLENLSITLEVNIYRDFAAIYGNMYFPKLNTLFLVGSYITKDTIQFIITQSSLLNLHFVNSAIDNNVFSVNSISTLKYLQKIKFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ69</accession>
    <name>A0A4Q9LZ69_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0250p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000250">
        <property type="protein sequence ID" value="TBU18157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0250p0020"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="433"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="571" mass="65893" checksum="16AA4992EB9924D5" modified="2019-07-31" version="1">MLSFLKKIFKKRKAEDFDKPKLISTDFTLLYLCDTEHKRKTDFIGISSDKKTLISYSYSRINFEYKITTNLKISEDDVYFIIPCDFTCDSLLDFLIICKKDNKYKMKLWSKNTYLEIPDGVRMPVLFTYSLNYRPALLIQTENGFIILHSFSDTKYEKIDSKITGNLSENHSSAFIDVNGDLKPELVLIMEEENKNRIEIYKFEKGDFNKIESKDIIVNKGGPMVFADFTRKGTNDIVFVTKEENFWFLNILINCRTPLKTKTYKQGLNWDMIGKEVENWGYKTDDPLFNIKINLEEMFPEMVPVIEIEMIENSPSGIFIGDLDMDGLPDILLIMEKQGNRYVKILQNTGESGSKMFKPAEFATEIQKMTGIISVSPCDPENTGRTGIMINHLVDGKPRLSFSQNNFSVENLKLSALTISPDTKKRSYSSGIPGISYLFTNADEKLLWFGCQMPQSSFLHLQSPNVYWGLGNMNLLVDKMYVTGSQSSKYQSYQINNNFIPNSDLVFRPITPSKIEIDLFLNLGMYALFVSIVVICVMVINIILVFIFHFREKRKIKKLEKAEESIFFRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ72</accession>
    <name>A0A4Q9LZ72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0544p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000544">
        <property type="protein sequence ID" value="TBU13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0544p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="411" mass="47393" checksum="595D88BCB0E9BB73" modified="2019-07-31" version="1" fragment="single">QQGTSNSTNKQQDVTKSTNKQQGVINSTNEQQGTSNSTNKQQGVINSTNKQQGTSNSTNKQQGASNSTNEQHPVNNNLIEQHPVNNNNIEQHPFNHIDPHIPDYSVMTRQDIIFKLFLEIKELEIKNFILRVLIEKKVLNKEDKDLLIEYISKCKDISTLNVILERCDMLFGDNKEYYRDVICRIAMMKGVSKRVRGVLFSIVDGLKEFYISLLAFIEAQLAKLYNEIEKAKFRAKWINAEKKGLLNKGNIGPPKGMCQHCGKSSKTVYHLETRCEKMPDHDYIRRYNEVVRYPHLLLNRYKFKSSKHIRSHSHTEIRVDIRIKTDYLNNLFVDDLARYCGAYIDLIVLKKTDEAKASMVLLKKPDTRRTNKTLMALSINQYIAISEGGTTLEEQTININEESDSEGNYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR7</accession>
    <name>A0A4Q9LZR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription elongation factor S-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0204p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000204">
        <property type="protein sequence ID" value="TBU19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0204p0040"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="7">
        <location>
            <begin position="79"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="26916" checksum="AB80F7D6791DA6D7" modified="2019-07-31" version="1">MVKEIEEFKRLILENDIVAIKRKIKNVEDPKICNDILSMTSSKEITDIVKDWMYSISSDSGVSKGDINCINKYFGADQTKNKIISLFFEAISNNIDSPDYEKVAFVSIKLEAVISSLNKSKDAKLVRSKYLNLKDKSNPILCKSVYEGIISPEKFISMSQEEMKSDLLKEKEEDFIKKSLFDSQIAKKEAETDMFFCTKCKQRKATYRQLQTRSADEPMTTYVYCVCGNTWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M009</accession>
    <name>A0A4Q9M009_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0180p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000180">
        <property type="protein sequence ID" value="TBU19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M009"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M009"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0180p0020"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1028" mass="121961" checksum="1381C352C78730A9" modified="2019-07-31" version="1">MVVEGNIERKSQILNMKSSVEIGLYNRHYYNTEHKNYISHLEILGPLVICIRVEKYFVRGLIKSVFGINEFKFLKSQNLYKLDEYIFGLKCCTTAFFYEIIESSNIKYEEKKEVAKSSIFGFFNVKKIFGTNKSLKFTNDSSKGNTYSDIMSVSSKFTCEISNNDIEKIRDKISLNRTSFTFDKIANKFIELDEDKKDYLKILDENIEEELIFDIILNESQNKEFIISLLGQKIDKKDFVLLKGTKRIDSLIFETSLINIKANKNEMKLKMAVKEFLEIHKNYYTLLLSSYTDVVLGFYIKNWKLDYQEKNAIFNNCFADFLQLILHESSFLEKIFKKIMEILNLDMENTEKHSLNVDKNYDFLILREEKKLFEIDKNIKEIQSKIENMYFLILKSFDKKNIFLLVDCFYDVLDTELRNVESVYVNFSKEYDIFMNNITTNLKFYNFENIGNIKFTFYEIIKRMTVINSFLCKISEYYGDSLEENFRRMKIINTKYKIITQRINDERDIICMHKRIFEIQHKIINTPGSLINNERRFIKVINCKVYNNIIDYTLFLFNDVIVFTKRIGDEISNLDLDLKNCNLFFIKMVNLKDIRIKNYRKGFFKIIVSELVTDEKHKSMPGFVHTKDLHYNIESCIFVCNDQDIKKQFVQKVYICQNDLRVMASSADLYLSYSDPPIFYFVYDFEKNPKNLECGKYLMIFSDESTEDSVKNHRWMDYLLDSDRSKKIEIKFTICLGKKVKIKIDNFINNEFKEITMKKENFEQNFSVYFKNFLSTVNPSSQNKNETSFSLINDLKVLYDLSLKDKKNKISLKKNVGKDFFVTEKVELFKLLFENIEIRLKLLNSKNLISNVKKSQIKKSNNNSDEYTDTDSFRKTTIIQVLKEPNSELTVNTNDLYNINSIYILEKIQEMISTKVNFDTLNSIDIIVLTSIVSTFFKYSITQIFSYNDILELHKICKNRDTKTSEIFLNSLKGNRKDIFLMFIHHFRDVSKIISTSFFKDLIFFLFGNFIKKEEFDDNYVEILLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M071</accession>
    <name>A0A4Q9M071_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0164p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000164">
        <property type="protein sequence ID" value="TBU19955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M071"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M071"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0164p0030"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="44976" checksum="73A17DA100C042B9" modified="2019-07-31" version="1">MENILLKGIKQNTKAEKIERIQRYEITGKKLEEIKSFELLNIELQNKLNKSGFIKPLLIQRLVIPYFINKRSIIVNSHTGSGKTLAFLIPILHLKKKSLILVPNSILQEQICSVIEMIKDENLNILKIKNSKDLKSIDNKRYDIIVSTPEILFETENIILLKNIRNLIIDEADLIFSKNNLKNLEKLFSLIDLKKVCLSVFSATINKIVTEISCVFDVTKISVFSLNAINHEFLFCTTNSLKQISLKTRVDEGIPFPCLIFVKKEETAVELSKRFEKSAVFFKNDQKVLDDFRLKKIWILFCSDRLSRGMDFYNVKSVINYNFPKSKTNFIHRIGRVNRNNFCDQKVITLFTKEDFLKLDRVITVLKENKSEIPESVINIATKAKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0A3</accession>
    <name>A0A4Q9M0A3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0415p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000415">
        <property type="protein sequence ID" value="TBU13490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0A3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0A3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0415p0020"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="324" mass="36531" checksum="31B3026357628E9E" modified="2019-07-31" version="1">MEKRKIPISSKYINSSGINNFKNAIGIDIGVNIIKIAFLSIESNNLYFELISFKSKNLDLLNQMLMLENKDVKIYLTEGNFHKYIEKLKLDTNNIVIVPKIKAIYKGLECLLENNIGNFFLYENNKKKTVKTKGPCLVVYIGTGVSIIKTDVDGYTNIASLPIGGATFFGLAKLFIKDVEFKEIFELLERGKNENVDLGFSDVFSNQNNLKETELDNSILISLGKLSIDQKSDFRNDDILSSILHMILNNIIYICLNEYERTNSSSLVFTGYFCTEDCIIKKISEITNKLSNQKVNPIFISNSGFISSIGAIISGINGYNERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L2</accession>
    <name>A0A4Q9M0L2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0246p0040</name>
        <name evidence="9" type="ORF">CWI38_0248p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000248">
        <property type="protein sequence ID" value="TBU18233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000246">
        <property type="protein sequence ID" value="TBU18336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0246p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0248p0040"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="430"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="574" mass="66075" checksum="4B40D4E7BD21342E" modified="2019-07-31" version="1">MKDKLKNVFKTTSNSSFGIPYTICEDFILLAYGDVENKRKTDFIGTSLDKRTMMVYSYCRNSNTYKKILQSKVFDDEIEHIIPADFDMSGKISFLLIFRTGILYRNKILFQEKAINNLPNTERIPILFADLELQPCLLVQINKEIKLLHKITKENFKIEKFLEIEDLSLSHSSSFVDVDGDLKADLIFVTNENDNNKIVIFTNSNMNYERSPNEILIGKTGPIVFGNFVGDGSNDIAYISEENKNWYLNILINKKLKFCSNKNKEKCIDWQENIGTKATDWGFEKDSEYHIRIPLKRFYKDLIPITFLKEIGNIPGGITVTDLNMDGRPDLILTFFDKKLNSNVFRILENTGEFGENLFRPVTYETFLYKMKGILSVSSADPENIGTEGLVINREYDGTYILEYSRNYLGSGNLKLSAITILPETSKKAYGSAIPGVTYFFELYETSDIRIMTQMSQSSFLHLQHPAVFFGLGTLNLLVDEIFISLPMTSSYKNIYSIDNKIIPNSDLVLKPENTKIAVELFLNLTKYAIYTSIVVIIVLIINILLVYIFYRSELKYFDKIKKSEKYAFYFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M194</accession>
    <name>A0A4Q9M194_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0211p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000211">
        <property type="protein sequence ID" value="TBU19450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M194"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0211p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="623" mass="72368" checksum="265A9D7361B2457B" modified="2019-07-31" version="1">MLENANGFIFTRCINENKKPTQNISTSSFTTTPPYQNTDESFLISTFTNKKTKTFPPTTTTLPSFYTQHNSKEKNKTTNIFLNPFTDIKKNKTKIKTNTNNKDNNRNKKDSNPFKDNNKDNIRNKKSKNDSNPFTDNKTNTNNKFNNQYNNRNKKFKKNSNPFTDKTKQNIINKYSNPFTDTTLLPTNSINKNLNNSNLNKTNPSSEIKPTFIFEFVNKKNIKNSKFKENSKDNKKVGKNIKDNKEIGNKNIKNNKDNKENKEIENKNIKNIKDNKEIENIKNIKDNKDNKNNKEIGNKNIKENKEIESKNIKDNKNNKEIGNKNIKDIKELSKEVRNKNIKNIKDNKEISKENNKELSKENNKELSKEVRNNKYYIINNTSNIPSNISNIPSSISNPSKFYERLDSDENRNEKILKILSWGTKYLNEKEGKNEYGDKLMGLFKGSVVFKENNSFLGNSCLILEEIENEMKEIENEMLKWKNIYEEVYIENVRYVDIKKDIMKGEKEGVNNKDGVWGVNNIDSVWGVNNKYAIEEGVNITTDNLHPLNTPNLTLDTCINSNSILYKNMKEKLDRLLLIKKVVFNILNNNKNIAEELLKSILSYVCVDKGVDILLLLRAFSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C2</accession>
    <name>A0A4Q9M1C2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0061p0080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020404151" evidence="2">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="23643" checksum="CE90F9DF022F557F" modified="2019-07-31" version="1">MNFFRINKIISFLCLLKVSKSSVGACNRVSTSKDPELVNQHDETSSREASYLGSVLDRPRKFTKKDILVCDSGNIMLRRNPVSGWDIYESLDSSNDSKAMGDRQDKSVETEGARIFKSSLGERELRESQSSSERFPVLEVNGRNEISADNLFSLSGAQEYSNFLNYEQLSEDSDYSDSSSSSSTSTSSSTSSSSSSSESFEFFSEYDGASTMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C4</accession>
    <name>A0A4Q9M1C4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0272p0030</name>
        <name evidence="2" type="ORF">CWI38_0569p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000569">
        <property type="protein sequence ID" value="TBU12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000272">
        <property type="protein sequence ID" value="TBU17659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0272p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0569p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15778" checksum="0DE23230362B71DF" modified="2019-07-31" version="1">MSFFKTKGFKIAAIVSGCIIVLCLMVFELGYNEVTNIIKEFEKDFKLVSETDEYKNLIVELKKTEIAGAGCGKQYKVFTIIKLNHKINRQQFLEIFEYKKNSEVEMALSNINQIKSFVIELSKFSNIVKNDTFLAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E7</accession>
    <name>A0A4Q9M1E7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0057p0100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1E7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0100"/>
    <dbReference type="OrthoDB" id="2196240at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="399" mass="44707" checksum="DF7B340D2EE4729F" modified="2019-07-31" version="1">MEKEKNLNIFRRWFLDTNAAIQFSAIIAGLCAFSIGLNMSILDSAAAIFMECSEEDSNLKRCVQCTKNEWSFFVSILSLGAPFAIYLSKYTSLSKKKFLLIANALYIIGFSIIAFTYNYLSVVLGRFIVGCGVGLCSVNVPLYISYLSKNKLIINYNQLFIIVGIFSGQVLSLGFTNVDNWKIRLYINLMFLLCHTFLLLLIKNVEFSVESTKKSIFSIFTSKEGRKAIFPALSIHIGRQLSCVNNVIQYSTMLIASSLSPAQIVLSISCVMMLCTILHFYLIATIKRRTLLLISLLITSFGLFMMSSGKFIEFTVAIYILGYTIGLGPIPWNILGNIFPPEYKEVGSNIAVGVNWITCFAFSYIFPIIFTNMGKMCYTIFGSIIFVLAIYISIYGKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J6</accession>
    <name>A0A4Q9M1J6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Di-sulfide bridge nucleocytoplasmic transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0156p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000156">
        <property type="protein sequence ID" value="TBU19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0156p0010"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="2">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="26155" checksum="FDE69897D0CBF8E5" modified="2019-07-31" version="1">MKEVPLNVEMELKWKNMKQKEIILEKCKYLSPIKKRKIENTFPLYLPDYKIQENERNVEKKVESEQKDRQKWKFSDIKPYILNAPFVIISYLHLFFNILIITILSYTLVAIAFGIQKDVRNRIFQRKIQISKIIEESKKNYFVNKCHPSTRVPALNKLCMEWECNMQRGIDSAEFTRIFVEVLGDVCDAFVRKFSFKTTSIFAGFFVLFLIFRNKNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q6</accession>
    <name>A0A4Q9M1Q6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0039p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000039">
        <property type="protein sequence ID" value="TBU20660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0039p0060"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="24138" checksum="9DD2EC275EF92446" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R5</accession>
    <name>A0A4Q9M1R5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0136p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="635" mass="75984" checksum="BE58F71DEB9E9826" modified="2019-07-31" version="1">MNLQEIYEKNDVIMKFTRENKKHSEEKSFELHVYLFTTINIHLEFKYDIKENYKKNNEFVTILKNIDIKHIINFCCFLKTYYIPTNNIKCIDFIVYIYIFEKMNLNLLISFISYPGRNNIKEFPGSSSYFKKYTISKSFFVFIFNIFEKIYFVSQKSLKILIFQDEYYSNVYEYEILSCEILKNSFVVSQSLVEGINYLILKDENFKYIFTIFFSIYDFDTLLIYDVNVLALESIAFIFSILQRDIRNVIFYHICFKNELITFLNTLLNESINPKLSNFIKQYFRLISNHHINLTNIKILMSGFCFPSPEGSENMFRCLISNIKHQGIKYYCFLRLKSSIINVDGIVENFENILYQKWSLLETEIKSFNFNDRLLKLNIHEIQLKNIALNTKDLNKLFILDNLKKIFFIDSTLIDASKIYIDKNKSIKTVKFITKSFKINTMLLEFLKSLQNLDKLSIYTDRIISDRIENYTTSKNFIFLKHFKIYSKTLPKCSNSFFSMLRISHIVSIQTKSEMTIFSSIFKNYCAFKLIEIQLLKILITQTEQKLLKYSRKLVILDISECTFKNISFSELFNLQDRYDIQFLVLKEIWLIKKDFEFIIKLKRLETLKLLDCSYDYECMCYLQLNILCKLKMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y3</accession>
    <name>A0A4Q9M1Y3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0160p0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000160">
        <property type="protein sequence ID" value="TBU19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1Y3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0160p0040"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="143"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="374"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="484" mass="53837" checksum="940E429D8A2C0A50" modified="2019-07-31" version="1">MFKNLFENEILEPRLTYRKITGVNGPLVILDGINYLKYAEMVNLTLPDGTVRCGQVLEVSGKKAVVQVFEGTSGIDVKRTQVTFTGDTLKLPVSEDMLGRVFNGSGKVIDGGPDIIPSQILDIQGQPINPQCRIYPEEMIQTGISAIDVMNTIARGQKVPIFSASGLPHNEVAAQICRQAGLVKKKGVIDSSEENFAIVFAAMGVNLETAKFFETSFKETGSFERTVLFLNLANDPTIERIITPRLALTTAEYLAYETEKHVLVIMTDMSSYADALREVGAAREEIPGRRGYPGYMYTDLSTLYERAGRIEGKNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYIDRQLHNRQVYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGKDAQAMKAVVGEESLSNEDKISIEFLERFEKEFIGQGHNESRTIEESLDLAWSLLKIFPREMLNRIPSAILDEYHSKPVNTDMTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M264</accession>
    <name>A0A4Q9M264_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0236p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M264"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M264"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0070"/>
    <dbReference type="OrthoDB" id="2186843at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="428" mass="51102" checksum="22F3F2025112A100" modified="2019-07-31" version="1">MVVRGYIIPDQKKYVSKTLIKGKFKIDEDSFNELCILSNIYPKLCKRKQKYDKRNDIYYLIADIKKIYLSDLHRNIKINQRIKKMRYKYLKREEIFREIKKDLGDGRFKGEERIGEMRDGMVVGEEILESKHIDKGNIEDGNLEKENSKVENIKKNELDENINIRDSNISIPYKTDKVYKFKKYNFAEILKNKYPSLLDSMKGLKESLCTIVLCKTVMKYECTEIINKYKNFMIKHKILKKTFIGKTGIYYLLSFDGLEIVWIYSYDYENENKDDEIKNMNVLKYLYGICNAHLKFLLFKLEKIYSVKENTNGVFKNFKFYILDEKFKEHISFVVMAGDGNISNTKEESDYVIGISTTQELFVHPQFVFDSFNANKILDHYKYMSPNNLPDHKFPFDYNFYENITELQTMIMSKNTKERIKEHDKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D5</accession>
    <name>A0A4Q9M2D5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0015p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="623" mass="74582" checksum="AFE3DABACFC18610" modified="2019-07-31" version="1">MIKFIKKIFYTELNLNKAILSELEFENSDYINIEFISTNISIKETSFTNKIDIYSFYKNKTVVFIEEQISIISDEECSSEEYKKILIIYLNKYISKLIADIKKDKYNEEFFYLRCAEIYIKLNLLKMCDDVIRIGFKLAKRKGFVDLKYNLIEISIFSQIYKLTKIEYLNIENIKNIVKIIKNFRNIQREIHLVTDLLEYMIFSDILFILKHINVEIYSYNERIYFFYKLASALDEKGFKRLASMYFLKTFLSIQDCTNLEFKNYIKCKIFDMITEKNWKKIFESIHKYVISEDYQKSGICYKFYTDKLFRSVEYLKYEESSFLIKNIEFSGEKNVFLDRNETFLFEAKKNDNKNEIYFLENVKIEIELYSTGEIEILAILGKKIVKNKSVEPNLENISESIIKIDIFKKLKTKNVFNINIPVSIEIQNILFKKNDKLFYTNIKNVKLEKIIPKFKLKLLNYKQFISLFVGETVINKIKFKTEKANDFIPKMIISGLEKYDSDFHKKEIFYLFKKIEPFKGNDISVIYWINEDFYEKILINMNTIVEKLFELEILAENRSNSQIRICTWITPLISFEAENSLFKYNFYIKKKQKVVLIGSDNLVILKWKIKGREGSINILEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G2</accession>
    <name>A0A4Q9M2G2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0007p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="7096" checksum="B08491B42E69F544" modified="2019-07-31" version="1">MENNLHENYVRNISDEITLCIQKIKNKQDNMEGISKEDKPLVMINYDCRMIEQVVQLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2R6</accession>
    <name>A0A4Q9M2R6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0065p0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2R6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0090"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020278601" evidence="2">
        <location>
            <begin position="25"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="332" mass="38423" checksum="1038B71129FC6FBD" modified="2019-07-31" version="1">MFPFISFEYLISMILLLYFSKCLDTSVSISSFLLISEALVVVDEASYQNSYTSLYISDAISKFYLVYPESGLFDVNTSELISRHNELVRCLHLLLLNKYKFKSSKRIWSHSVQEILDNEYAEIRVDTRIKTDVKIQNNRPDIFILDKKKNKITLIEVGITSQDLLQLVEIEKFRKYDLLANELGLIYKCSIEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRTGLESGLNAEENWERASMCVIMRSEMHEKPTPPLKGEKREEDGAKNFKPKNKAPLISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2X9</accession>
    <name>A0A4Q9M2X9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0182p0060</name>
        <name evidence="1" type="ORF">CWI38_0646p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000646">
        <property type="protein sequence ID" value="TBU12742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2X9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0646p0020"/>
    <dbReference type="OrthoDB" id="2196034at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="560" mass="66916" checksum="5441AAFF5D939484" modified="2019-07-31" version="1">MKNNERRELTRFYDLIKRKDYKKIEMSLNTISKINATAISDPKDLDLLKQYTKNKEILKIIMRNDIKFLLCNKRKIHKEMINTVLYLDNAYIKEIKDIIIDNIIIQKYENYVYSMKSNIRKLCELKKAIDWFENSLDSLRLNESDIPPQWNLEGDFVFKFCVLTKQIICNIIFHNNIDNKDYLDGLKYILEFEKKYCNHIFSDNCCENNNNTNNDKNKKIIFKNTGVELVEDNKSSLNDPLDVETDTKITKKDLEDLKKNCKHRKMLSQIFIPYIEIYVKFLFIEARKIEMDQSKKEMKIVCGFIEFFRIIGEIFLEIQYFESEKIYEYFLAEVNSIAIRFIEKIEHKRNFKEAVLILNTFSYVESTSVDLFKKIYEKNNKICCENVIQKELRLKEAQEYTFIDKYYQKYFKQLELSDKNLKFSEFLSNFLQNEIFGADLLGISEDVMLFLLELSISFIFSKIMFLKLNTSKAEQLLFEVSDFKNIHRNKLIYVPLISMLEKYLKIFLCNPNDTETFITNFFHFSSGSFSFSQIISVLEDAKNNVNLFVRYKVRVKDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3G3</accession>
    <name>A0A4Q9M3G3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0091p0060</name>
        <name evidence="1" type="ORF">CWI38_0140p0050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000140">
        <property type="protein sequence ID" value="TBU20056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3G3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0140p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="406" mass="48753" checksum="0F28C1C7B81E7E01" modified="2019-07-31" version="1">MDIAKKQKFFAKKCLDIYKRETTAFELLPKAIDVTHLLFYQNIPELAVKSISGYLQSGISKKYEFLIYGTTKYSDDSVREITFKTLQITQLNKKNWFIFFSNIPLLNKLSIQNHSHNIIGNKCLTYFLKYFFMIFKVIKMLMKYQNGTLRKYSYVSIDDITNGLSRKIPDCYQNIPSNLKYDTFNLLCVKIFSENVISEHTIDREKMINQFNRLFDESKSKIFFGCYNYFLIYKNNSEIHEETDIHKLSYKTIINVYQIVFDDLQILEDGAKNLILSERSFCSKNFSYDFEFMYLFTLKNTKDSDYKFFILFSRDSKKFVFNYKWFMNRAYNDIIIESSFYLAVFAHFKLYLIEFIEEENPRYFKIHRVKCSDFRIKIFDEEKISYLGNLMSINSFIDMLVFYPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3N9</accession>
    <name>A0A4Q9M3N9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0020p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000020">
        <property type="protein sequence ID" value="TBU20817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3N9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0020p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10058" checksum="D757D6A7C9FB8927" modified="2019-07-31" version="1">MKRVLFVVIYRGSGRGVLFIRVVGVIYKGSVLEGCVSSSSSVLEGNSRDMLEGVSNSSSVLEGVIYKIILKRVLIISKNTNTLPLTLQSPNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3T0</accession>
    <name>A0A4Q9M3T0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0037p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000037">
        <property type="protein sequence ID" value="TBU20668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3T0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0037p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38602" checksum="748FF31BD73ADE42" modified="2019-07-31" version="1">MQRTPIPSTVEFKSEHMLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSPIKNFLKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYNARNNELVSVNDSSRCLKKGSVKLRMCQHCNQSRKTVDHLATRCEKMLVVRCIHLILLNKYKFWSLKRIRSHSVQEILDNEYAEIRVVTRIKTDVKIRCNRQDIYILDKKHNRITLIELRKYDLLANELGFVYKCSVEIIPYVMTWDGIVTKYYKTYVRRLQIPMNVEAYIQFIVLKKTRASLSVILRAEMHKQPIPPLKQVENEEDDEPTTNTNEELEFKKEIEVVKMVEIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3V1</accession>
    <name>A0A4Q9M3V1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0097p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3V1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="741" mass="87631" checksum="B154F75A4FA28D98" modified="2019-07-31" version="1">MANRRLTNIFFYYLIGYGNAAFLPESESFLYEDQDNKALRAGNLNRDNNSQESYEYIRQSNVSENHLLSIPSTSSNRFQPYYKPHKSQENGVYGSENAFFNNQPENFPVTLHPGQSEPQYNIPGNLFPGIYFESYGVSSSNQNETYGYVSNPMTVTQVHTFTYQEQQSTSPLIYQNLTNKQNQWNFIESESTGFTSDVVTGLNSAILHPGIPECQYITSDAKLFNRPNKISAAKSISETQNTGDTEKVWNEMINSKQTSIATADNTDLLSECTLEDKKIMTSFKFRNYFVEFSMTRFKNIDSAVFIKLKHMQEEYRLIREFFDIDANISSNNKKKIIARIVDSCFENIDFFKKSENETQIKLYISYIRWDIERIFQNIFLEDDISNLNTEFYVKNNLSTSKELERIFLKEIKKLENSNIDITYLSNLCTLFVNFEKSYDDVNLNKMWESLSITTLPEVLLKLKNCMEENMFYEICRFLDLYQHNLENHIKKHHRISTIFILDVLHIHIDRIADIKFIHKESQNNFFDSKFTVSYNIYRVGKIFEELLKNLHNNEMRAYCYGMLNVSRFFFWVYSFRKKHGTLLFLQISCLIGMVLDIEFEFNQTKIKEFVVFILFIMKKTQHQQPEFYNDKVQYFLEINASIIDNIINFNIKKIREYDVSVRRNPHPNKRVNIFHTYFSYQAILGNITPNKDEIFKKLYTSQLYLIAVLGNKYTMHLHKQDHIFDGHTDLYKKINKFYTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3X9</accession>
    <name>A0A4Q9M3X9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0010p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000010">
        <property type="protein sequence ID" value="TBU20907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3X9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0010p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6198" checksum="9A71C7E293E60E8B" modified="2019-07-31" version="1">MDFRRSVIPSEKSINFIFKTSHANKTFLFMSVKVSVELFMDTNFTEYIERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Z3</accession>
    <name>A0A4Q9M3Z3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0029p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000029">
        <property type="protein sequence ID" value="TBU20728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Z3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0029p0040"/>
    <dbReference type="OrthoDB" id="3693100at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="787" mass="91351" checksum="16CAEC918A9326B2" modified="2019-07-31" version="1">MLMMQLESSRRPRYAMTRKHKARKQERLSTSETKSLRKIMREFNLDLSKINDISEALVKKNETLNVYEKKHPINESREKFRKRIVCLSLSEVDFIYADGIDCISNFYIKKLTSLHKYLSDIVKFMFLEGTPQADWYYCGLTYLIPKDTPKTGSDYRTITCISNLRKLLSDNQLGAVRGALLNVAINKEYGNNIKATWIDVKKAYDSIDKAYLTQVIENLNLPDWILKFIKGLKKIMNKDINKGILQGDSLSPLLFVLCMDSLSRKLNEKYSKGTIKTDAESHATNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIGLEINKEKSATNDPCCEDTATLLEGIGVYKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLLNYHIGVLRLEPADFSKLDDAVRAVLVKNKILLRPGGKERLYLPRKELGRGLHSVEFKSEHMLLQFLDCLKKHKDTSTRRAAILKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVKVFCYIHDRNVFWGAEGICHHCNRSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKSHSVQEILDNEYAEIRVDTRIKTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKSFYKCRIEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKIVETISFDRRRGLDWERASLSVIIGAEMHKQPIPPLKQVDNEEDHVKTENTKNILTLILDGITTAKEPITNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4C3</accession>
    <name>A0A4Q9M4C3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0047p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4C3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0050"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="133"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="300"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="488" mass="55205" checksum="7FEE093E78F5B72F" modified="2019-07-31" version="1">MIGSDTGKDAYKEEENVYTSIYENMKNNVFTKQDKVVNKMRNGYIGILCDKTARIIENDPLVELVERDREVVINSIVDSKVPYFKVKDLFFESKNDEDEIILTQMNAPWGITRISDGEKYSFKSLYKYPSSAGEGVDVYIIDTGIEIDHPEFKGRAKWGINLIEKSPDTDENGHGTHCAGVIAGKNVGISKKANLIAVKALNKAGIGMISRLLLGIDYVIREHSKKIDEMSEITRKKFLNSVKIRNRNPKMFKKYRVPVEIDESEEYQFIKEINEADFQVIEKDKDKFLTSLEEYMNIEEIKPKTVVSMSVGGLRSKAMEFTIDYATMLGIHFSVAAGNDHEDACLYSPGSSKNALTVGASTQYDKIAFFSNWGSCVDLFAPGFEILSSWINKDYRVVSGTSMAAPHVTGVMALYLGENSYSPKQLYNRLIRDSYGVIEDEDAEITSFQEIWPISLLFDKENTNNFPLVSTKKLLGRVNKKKLQKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5K0</accession>
    <name>A0A4Q9M5K0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0001p0230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5K0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5K0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0230"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="407" mass="45378" checksum="19CEC3724C81D495" modified="2019-07-31" version="1">MKSFIFYIGYLVKQVAVVKCQYSNDCSSYSSNISEPRKDGYLLAGDKHVNLSYRHRAFKRNKNHSPKDKKNKFDEAKDFLEAFYVQNKSSSLFTIFDFMYVCDNNIPNHVSVCGNKTGTGYIERDFDFLVDILINLRKNILDVKACRWFLRRFYTYINDLAQHTKKSPAINFTSSMTIQQMFDKDPVGLINGLMQDSDYRKYFGRFLRDLSSAIKKTHKPKQCKPKEKSSKKQKCECEKILKNSNNNQELYYNVIKSMIEVLENKIESCIKKEKSDLAKMKFTYVLYIPGGRENDGKITPDRYIKVFPVKKKDIKDPEEDKPEDKPEPAPAPATPPAPAPAPATPPAPAPAPAPAPAPAPAPATPPAPAPAPAPAPAPATPPATPPAPATPPAPAPATPPAPDPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX16</accession>
    <name>A0A4V2JX16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DSHCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2072p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002072">
        <property type="protein sequence ID" value="TBU10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4V2JX16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2072p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1292" mass="145157" checksum="6E9C3634F7709D2E" modified="2019-07-31" version="1" fragment="single">NKVSYKQQGVSNSIDNDPLINSTDKQQGVSNSIDNNSIINTPYTIPLNNTLPSSDILTLPQFILFKSLALRGIATHHSSLIPFIKEITEILFNKSLLKIIICTETFSMGVNLPVKCVIFDSYYKQGKLLNNSEFVQMSGRAGRRGIDDKGVVIINGIRGVRDKGSNIKGVSDKGSNIKGVKDKVSNKKGIEDKGTNIKGVNDKGNKDKGVNDKGSKDKGVKDKGSNVKGVSNMGSNIKGVKDKDTKDKGVSNKGSNIKGVRAKGTDAKGISNSTDKQHPLNNSTIKQHLPNNNTSKQHPLNNINSKQHPLNNSTIKQHPLNHTPYTYNPVTTTYINNTLTVLRDIIYNTSNTLYSCSSFKLSYNMILSLLINNINIMDFLKRTFMEDKVQREYKSDMCVIKKEEDSVKRVECSVCGVIGREEIWGIILRIMGDNIEGKLEDGLEGVNNSIDYYKGVNNSTNVYHTVNNSTHTYKGVNNSTSKQDPVNNSTHTYKGFNNLSNNYHPVNNSTHTYKGVNNSTSKQDPVNNSTHTYKGFNNSTDNYHPVNNSTHTYKGVNNSTHTYQGVNNLSNNYHPVNNSTTKQDPVNNVSNNYHPVNNRICKQDSVNSTNHNYIPVNNSIGKQDPVNNLSNTNNLTPPLLNYLYLLYEVCYCYNILITKEVLFIGMGVVIKNGNLYGIIKDIKGDNIVISNKDIYTDIGGVSYNEEGVSDSIDKQQGVNNKSSKEEGVNKTYKQQGVNNNSSKEEGVNKTYKQQGVNNNSSKEEGVNKTYKQHPFNNSIDEQHPVNTNAYKQHPINNTKNITQHPLNNSTDNNTYSFTLPSYPHMYIFPVKEDLIITIKDIFYITNTCSNKDNNYGLSNCYIDFTINSIEGVIVKERLKKVLVRLTGVNNSSCSLKGCYDHIDSNKEITGVNNNSCSLKGCYDHIDSNKEITGVNNISCSLKGCYEQLDSNKKITGVNNTPEYLKGCYNLLDHYKVLLQSFYSLKNIYFLFNKHSSKHLSLISEYYMRIRVLKYIKCINENNRVLLKGRVSIEIRSCYDLIGMCLIFNGVLSNISGEEIMSVISCIIEGVNNRIYEGSIMEGVINKDSGYKGVSNSTTRLEGVSNCINRLEGLNTSTNTYHPLSDSTDKQHPFNNSTNTYHPFTTSTPYITYLYPFPKEKQNIFINIYNIVNNTYNYITNIMKSFNLQPMYTPCYYYILPIYDWCIGKDLLYINNTYNIQEGDIIKVVLRLIEVCKELKGVSVLIGDMVLYNKIEEIEKCINRGVISIPSIEEIEKCINRGVISIPSVYHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX66</accession>
    <name>A0A4V2JX66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1696p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001696">
        <property type="protein sequence ID" value="TBU10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1696p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="542" mass="65050" checksum="3E5E374456E6DAD5" modified="2019-07-31" version="1" fragment="single">MNVYRYMRMNMVFNGYIFIWIYIWYKIISFEQINARKFRYRFKRNENSEILFFCCEKMSNEVLNEDYEIFFFADANLESYSEENPIFIYREDNFIQFEVLNSFLVSSASENEARNGMIQCGHELSYFLKLSKDITEIPNNLDNHQFKYMMILLKFLKAVENKNFFEFYQALICQYFFYQNTGARRNEYFDFEKIFNSNFLTRIDFSIKKNIFSTFLNSYMINYEFHNGNLILFENSRKFYDVALFDENIPFKNLLITDFRVFCILENILKDTNTRKIFKLLLNETNIKSLIINSYKGCEIFDRNLHFFILSIHTFKSIVMANFIKFSSFFISKVKAVFELNIEYLSLKNIVVSKSILGLFLKKGGLKGLVLYNVNIMEHYGFTDVYSASNETLHFIDFKNVFIGVNWWNNFFSSANVSKIILLFRSIIAEEYFLQEFKNLNRKMNVVYFKAQFCFRKISKSFIKCLNNFEHLKTLKLKGNLTVEKDKLYLCQVIENMKKLQYLEICQLSYEFESFSLLLKFSKIKALHLENIFFDNDTLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX75</accession>
    <name>A0A4V2JX75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1585p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001585">
        <property type="protein sequence ID" value="TBU10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1585p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020840974" evidence="1">
        <location>
            <begin position="26"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="555" mass="65102" checksum="F143361AF3C416C4" modified="2019-07-31" version="1">MFLSRLHSLHYFILKTALIITFTSSSSSRNKAETGSKIINEEGTSENILITNEQEKILPLQHNHTLTKSQDNSLGHNLLNFNSNNLQNPESEKQNFQHPAHSICVQRFFELSSSYNRLYRYEFRSDSPSQNLDPGYCVYNPSVSSYSDQGIEYQSKNTLIGNNVLHNLSFDKNLLIPQPMSIESQQIRIAIIRILEYPSAGIYPDILILLTQAYFLDDILDPGCLHKYFLVLRNLVEIEKQIISINPRKEREFEQVLHANMENVDLSGSNTFILLYAPTLISLKNFIERKLELYTSYSKNTISIFFGLKLIESVIIKTHKAISMILELHTLNNFSNATSYMNIILKKNSNIIYEIIFQLFSSAFGFNEHFKTIFQLIIDLQKKKCADILSAKKIIFDEFGLSFLPDIFFFLEESEINEIVGLYLKKTNFQSLTGITENHRPIDSINYEIFYLKNKTILKIICYYFMIFEDFEIRLFKDYFLYSKLNNQYLILKRRFEGFKHNLFLDDIRNGNNLRVLLYDTYCFFHYCIVYCYNRDVLPEDYLTKISNIYLIKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA5</accession>
    <name>A0A4V2JXA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1417p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001417">
        <property type="protein sequence ID" value="TBU11042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1417p0010"/>
    <dbReference type="OrthoDB" id="2190427at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="322" mass="39284" checksum="7CF91EB78DEB410A" modified="2019-07-31" version="1">MNKWVNNFLMISQIHPDDSDYEKFYSDILIFLQNNKSNHIEYLKIFTTAVETFHNKTLISMCYRLINSLNKECFESQVFISISLLQKHIKSRILRSHVFTYIFNTNLLQNFKKQIIKFLYDPVEEFNGLPLVLQHKYFEKEIDNFLSLNDITIYSKQVFISIKMGVFHNLDLFIYHFGDENNILAFKTYELFYFYIKKATTDTFQNFSIKDNKYICFTKPIKVSSIENFVFHFFDFIEENEILQKFYIQNDYESIKQILKKYLILDKEFKLEQRMNKCFYKKKQFYNYENINDINHNIESDLDYDYLFDRNTYKQKMDCIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH3</accession>
    <name>A0A4V2JXH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1026p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001026">
        <property type="protein sequence ID" value="TBU11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1026p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="29173" checksum="AAC6755F4072311B" modified="2019-07-31" version="1" fragment="single">IYKTYYDRSQFYLDIILVTQRYKNIVFLDLEKIDEGLKRSINFYKIYRLDFEKIKDYFIELNLKTKYFFLNQIISTLGNEIDYYENEEPVFTQFEKSNVDFNAMKIYSKKVIDITGNSKMFDLENIYFCKIAMKKQNLHAFMPEKHFAHIKLFHFKIIIYTTKPEIFNIRFYTKKTPLQNIIFLLRVSSIFNQQKHNHPFLKIIIKINKMNRTQKVLNWKEFLLNIKDLLQYNGMNSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK3</accession>
    <name>A0A4V2JXK3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0889p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000889">
        <property type="protein sequence ID" value="TBU12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0889p0030"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="31245" checksum="638CADEC72BAE5D4" modified="2019-07-31" version="1" fragment="single">DHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKAHLKRLEIPMYVEAYIKSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXS0</accession>
    <name>A0A4V2JXS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0118p0080</name>
        <name evidence="1" type="ORF">CWI38_0579p0060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000579">
        <property type="protein sequence ID" value="TBU12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0579p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="50674" checksum="5F09B6442D3DFC3D" modified="2019-07-31" version="1">MNVFFLLYFYKAITAIAKSTKHTKYTIDNIYDIMCKEMYRQYKSKVLEMNDVLEYNFLVFETLPEFFDVCDSEIFNYLYQKRLKKTYSSLICLIKSQDCFLQIKTDLIFKIKGNFCIVFNSRNIIGIHIDSILYFIKRNCYLRKSEGFKKERYIYKFLNSIVNHLKRIIDIICKQKNIIVIKAISDNQLCQSHALQNFMLGLLVNMKPNIDCDYSIIILKKEKTTITSPYNIAKMMRKAFTSLYYLEISFSLLQKCENNYLPPIFTNSLNHVYKIYIRNIVLFEMVARANLFELPISCFKSLLDENSKTKSIKFSSVYRALNLAITITLIKPLIMRKKTKTTEQNENFLKIEIKSSSEPVQEFYIYFNKKKFFPTKIARNETFEINPLYDSVEEEINFILKYLKSKEDDHFLVSLFCLHEKEVILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY84</accession>
    <name>A0A4V2JY84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0123p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0040"/>
    <dbReference type="OrthoDB" id="2190306at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="12017" checksum="FDF70C3F6516F2C6" modified="2019-07-31" version="1">MNLNEKYLLSLLSKYYFMGNEKYILSRLRLIEVSMQTQSIFCCTCLYLYIPSVNCKIYIDSCIFEVVCYGCNGKLRINLEKLDASNVLQVSNEKIKFNDFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK6</accession>
    <name>A0A4V6MVK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1612p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001612">
        <property type="protein sequence ID" value="TBU10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK6"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1612p0010"/>
    <dbReference type="OrthoDB" id="2189670at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="31751" checksum="B903658ADB389E31" modified="2019-07-31" version="1">MEKYLSKTIKGEYGNEISKLKDFFSLKNGHILVASMDIYLLTEVIKISLSNQQKYKKSIEENNYFDENIDFSNSYLVYYLDKKKSTSELYFLLEKSKTQDDFHLILTTISCMALENLDKRIKSRLNHNIIFLPVLPYKSVKQYVNEKAHKIDPRFSALLKNNLMQKYKINFDFESLFNILNSIHISLLIMILNCNIKNHKMIEQYRKFVFKHPELRNIKDKDISDALGDLLDLGFVDKKYNYVFSVDELKNYISKNRPFYLKRLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL2</accession>
    <name>A0A4V6MVL2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1284p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001284">
        <property type="protein sequence ID" value="TBU11282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL2"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1284p0010"/>
    <dbReference type="OrthoDB" id="2192975at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122311" checksum="0A7590659FB4147B" modified="2019-07-31" version="1">MKRDCTSEKDKKNISTKNPKLNSTLNHISNPSQFTPPRNKIIAYFFSFFLFLKNKFNFHKILTSIIYILFPRLKQFNKLVSPRPIQPLDLDSPSSSSKNTLNREIIRKQISQDNHSKTLSRYRLNKKSGEIKIRSYFIPTNLIPSPIIFLISIFQIFAAQDFLNQCTLYNIPMNDCLSSHYYPSQQFDNFVHSFNLPIFKDPTCNTRKCYLLINNADPHTCKGSECNNSITLTPCKGQNCPTPPFDSCQAPNCNNNTPTNTTPNTPSNTPTNTCQGPNCSSIVTVTLYQTKTVTIDTPFTLFREITSTLTAEHLITRYKVTTLTSTQFQTVNNTLTDFKTTTDFKTVNNTLTDYKTTTDYKTVDNTLTDYKTIDKTITDFKTVNNTITDYKTITDTETDTLTTTITLPKSITKVKHKHITHTVNNTLTETVTDYNTITDYKTVNNTITKIKSFTDYKTVDNTITKVKPSTLYKTVNNTISISESLTSTNAKNNTVDYKTVNKTIIKTNPVTVNNTITDYNTVTDYKTVNNTITMIRPFTDYNTVTDYKTLNNTITEIRPFTEYNTVTKIKPFTDYMTVTDYKTVNNTVTDYKTVDNTINDVITEIKPFTFTVTEISSVVKTVPKNKTRYNTRTVTKGVTVVKTVPVISTVTESVIKENSKITPVSTSETMPMANTFCQTCTVTDITPVSTQADVTSINTLCLTESSPKITPVSSKEKGTVTNTHCETCTVTKITPVISTDIIPVTNTLCETCTVTKITPVITTDSIPITNTLCETCTVAKITPVITTDSIPVTNTLCLTDTITDNITRTRTKTVIKTITDRERESSEIPTNEKKKYTKTIATTVSRSDMTPLIETVPQEKECLECKHVTITTYLDKRKKKRKTVVNTIYAKESVSSCNKKDKSICLDEKGKEIVTTIYVGTNKKFKIEHKDIKREYNDPKKSELKNMYNDIVECIRFFENEKNEELLEGGNFRSECGNFIEDDNKILVQEIELKNKFNNKLSNKNYLVLQDLMVFSFLYKDNFKSNLKFGNVLLAAFLFEVIEIELDKIIWIFESKAQESSSFEFQINILYLRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXX6</accession>
    <name>A0A4Q9KXX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1205p0010</name>
        <name evidence="8" type="ORF">CWI38_0014p0130</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001205">
        <property type="protein sequence ID" value="TBT99818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXX6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1205p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0130"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="17"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="433" mass="48723" checksum="48419EA70BADDAC5" modified="2019-07-31" version="1">MHGFILACSLVSAFILLFGLVSLFVKEKLYLSETLLATAIGIFYGPSVLNKINIAPSLSDDFMFQFSRLVISLQVVAVGIAVPKSYIRKEWKSLFVLLFPLMVLTWLISSGIICLVTKLSFLKSLVIGACVTPTDPVLASTVLKGKFANRYIPVHLRNLLTVESGANDGLGFPLLTLPIYLLTHSSVFEALKKWTYHTWVYEIFLAIAIGVFFGYFGRILLKASKARNLIDKESFLVFIIALAVTVTGFTALIDSDDIVAAFICGMVFSWDKSFLKDVKDSHLLDVIDLLINLSYFVLFGSILPFTDFKAEYWWCAFLIILFRRLPLFFIFRKFVPELRCNREAFFAGWYGPMGVGAIFFAYFAKQKLPDFLDLVPLVQCVVLSSVIMHGSTAPIIHVHLRKNKSNVQYVDMESNITEFESTSRVVNEHGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYU6</accession>
    <name>A0A4Q9KYU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair and recombination protein Rad52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1093p0020</name>
        <name evidence="6" type="ORF">CWI38_2056p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001093">
        <property type="protein sequence ID" value="TBU00164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002056">
        <property type="protein sequence ID" value="TBU10063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYU6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KYU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1093p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2056p0020"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU00164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="203" mass="23304" checksum="31C7DE987EE2B24A" modified="2019-07-31" version="1">MKKEKNNDSSISLSRRNKISKELEKRLGPEFISYRPGFGGSKVAYIEGWTAIALANKIFGYDGWSSEIKNMNIDYMDVENKKVSIGVSCVIRITLQNGNYKEDVGFGSSENQRFKSEAYQKAKKEAATDALKRALRQFGNCLGNCCYDKEFLKDIQKITKQENHKIDTNNLFRRYEFFKYEGLNTKENSSDMSFEMGNLDSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L5W6</accession>
    <name>A0A4Q9L5W6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit Sec6 of exocyst complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0523p0030</name>
        <name evidence="6" type="ORF">CWI38_0728p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000523">
        <property type="protein sequence ID" value="TBU02241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000728">
        <property type="protein sequence ID" value="TBU12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L5W6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L5W6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0523p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0728p0020"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU02241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="706" mass="83516" checksum="B35F5D02F43628A1" modified="2019-07-31" version="1">MHETLENVNDTLKYPSDLEDKLPSILSAYEKHVNEQEEYLKTKIRNSRDRINNSINLQQKIKSDIEIYKSNFKKLDQIYQSFPKVVNNYENIKIIAIAHQNFHKSYEMHKKLVNISNATENILKMIKNEENIENIHEEVFELEKFKYEIHFFSKNITRDEFLKLNEIINEIDRVLLEFENMFLLKTNNLINQLEINKEYLNQISKIVKKEEERDEITIKVQKGKHSHDAILHEIYLLNKIYFDREIKDIKNKTIKAIKYSINDKFPKLQNKDFNIQELNFIIEDMKFISETVNDKDLFIDLRFIYEEYHLQLKNFLDLNKNNLDASQILFLLEFINNYNENIEKNLNMQPETLGESLLGDSESELINKYLQIASEKLVSWISNITVIEVEKFNLRTSQPTVDENDKYISTGFINLLQIIKQQMEPITFNKHIFLQITSIVVENCHYFKNEIIKAMKKDFKPSVTLKSVPGYEEYVIMIGNSGLKLTQYINSLPLCQKTEVRELGNIFLEILKSSNTLLSEFIITTCGPILDKVFTDSWYEQDITKKLIITLEDFLGDYKITMADYSFITFVFEICNSLVFCYVKQITRKRAKILEDCSDKLKSDEKRLIQTFCKFADPQEVKNSFMPFDKIIPLLTTKNDDLFVVELKSLILVYPDIKKEFIKSIIKKRTDLNDSDKKNLIERLKECFGEEPKHNKKTLFSRLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDG2</accession>
    <name>A0A4Q9LDG2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2671p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="PITK01002671">
        <property type="protein sequence ID" value="TBU05957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDG2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2671p0010"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="30382" checksum="0A29E1FE1F7A169C" modified="2019-07-31" version="1">MEDRNTIFIIVGMAGSGKSTFCSTLLEWIHEKYRKEDLDTEEDKDDLVHTINLDPATLSENTYTTDIRDKINYTSVMQKHELGPNGGILTSLNLYLLEFHKIMDKFTEKFIIIDTPGQIEAFTWSSPGMALVSLLKNIGSTDNGEFKPLYDIKLLYIIDAPLSHKHDIFMSNMLYAVSLKCRFDLETICVFNKIDLSEDTENIIEWIRDYEKFRESLPEDEMNTPILSSMCLYFEEFYKNVKCACVSSLDGTGKEDFFRVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ14</accession>
    <name>A0A4Q9LJ14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2465p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002465">
        <property type="protein sequence ID" value="TBU07030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2465p0020"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="133" mass="15214" checksum="47F2D07FEFC2AA37" modified="2019-07-31" version="1" fragment="single">MNTLQSLIQNKDHKAISLLPSPTYDVYKGVACIHMEKYNEALNFITKNSYEYAYCLYKLKNYKKSIRILKKLENTPKVMILLSQCLYYLGYYNGAYEILSGVSSDDEIVVNISAIKSMAIYSSRGSINERLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL42</accession>
    <name>A0A4Q9LL42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2221p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002221">
        <property type="protein sequence ID" value="TBU08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2221p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="28676" checksum="B46248C8447CD754" modified="2019-07-31" version="1">MRFSRIKTDVKIRNNRPDIFILDKNKNKITLIEVEITSHDSLQIVETEILRKYDLLANDVEIIPYVIIWDGIVTKYHKSHLKRLDIPMNVEAYIQSIVFRKTFETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNKALISQGGTALEEPTINIIEESDLERKKNGGVCDMSNKINKDDYSTYKNNSLNNNRGTVSGKTIFLLETSSNLAPFPKITAGVVIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LM98</accession>
    <name>A0A4Q9LM98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XPGI-like DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2144p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002144">
        <property type="protein sequence ID" value="TBU09493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LM98"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LM98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2144p0010"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09900">
        <property type="entry name" value="H3TH_XPG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU09493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="27955" checksum="6ED8EA145972D827" modified="2019-07-31" version="1">MRHIEDITHEPKDRNDPNNLISKTSINIDSLQNTEILNQTQVIPENGITDIKISNNLIPHELNFAIAVQSILKAFNLPYIISPMEADSQCAYLNINNIVDGVITEDNDVLIYGANKVYRNFFKKNKVPTCYSLQNIQSKLNLNQLDLIKLCYLLGSDYNIGQKGFGIVKSLQAIKNNEVADSSIEFLKNIYLNSNVTEVKEYEIFPTNKISRKNDIIIKVKKVLNENYVDEQNINEIIKLIVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNF6</accession>
    <name>A0A4Q9LNF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2090p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002090">
        <property type="protein sequence ID" value="TBU09928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LNF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2090p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1290" mass="148976" checksum="DF42311EFEB9C98A" modified="2019-07-31" version="1" fragment="single">NPNLSSNPNLSSNPNLSSNPNLSHNQNLSFVSKQTHEKLKLFVYLNYLVIYNQNTKHLNNKTPLFFINLFNIFSIKNEVKRKKIDLIISVQIPTPIFNHKILKIYTSENPIEFLLINHSILILYTQIICTNFPFKKTNFKQNYYVLKPIKSKFILSILHLLNTQEQILLFKEIFNQQNIRKEKNIKTSCIEKNNCIKKEVKKNIKDNTKIDNTTIREDNKNTKIDNTTIKKNIDNNIKNNTTINNTIIENNLLISILKTKNISKLLQIFNFVIFNSINIKKEILRNIWFIKSFNLKDYLLLIRNKKKLKNCYKKLPFILYKNKIIPNKIKRQNILDLKYHRIFFYNKNILEMSMNKENVDTKNILEIYKNSDNKNSDNRDMDKKNKNNKNSDNRDMDIDIDNKNIDNKNNKNMDNSENINSKYKNYFGFNNNFINENIKFKEKEKEFLNMSRITHSRTHHTHKFFRKENFLKNKKEIDLNIFNNQENFLKDFLIFKNNSNSNKEGNNEGVSEGISDNTSNNKGISISKGNTSNSKRGSKRDSNSKSNNNIITNTRTNTNTNTNTNTNTRTNTNKKTIFQMTYEIIRKEIFPFKFLYKTEDPFYITKSEKYASSFQKAIKNHLGDERWSEVETLASTNLLVSFPHCDTDFERKRETAFVLRQSACIGTSFIYFSLNFSKINFIPKLEFQVKRKNKIENLFLPLKSKYSWSDFHHSCCYFLSIPLTDTNFDPELFIEQKLSFFKIKNQPTPDIPIFSNRHINTTSVTGREIRNNTVTGREIRNTTERDIPLSTGNIINVNGSISTNSNISVNSNISASVSISNVSNISTNTSTNTNNTNNTTNTNNTNTNNTNTTYTNISNIRESTVRDITGVRITDLRIDSLPNITGGINTSNRERDTRDINSSNRLYSNRDISNRLYSNNPTITTTITTTITTTNNTFNNPTNNTFNNPTNNTFNNHTNNTSNNPTNIHTNTPTYNPTNIHTNNHTNNNTNNHTNNNTNNPTNIHTNNHTNNTFNNPTNTPTYNPTNTSNITVTEYNFNEINTLDSYNEPGNDIDMDTDRESNNATINSYNELESNTSSIDNSIDNSIDNSIDNSIDNSISSNILDNSIDNTIDNSISNPTNPTLSPITTSNPTNPTPPTSITPPPHINEINELEISGMLYGLGLQGKLDTINHTFIYNIDTTTYQLLTITSIISICISKRSTCDPLLTKYLKNIIFSKPSYSLKYACCIGLSFLFYKSYNKSIFNILIKECNRYGCYYSDMYNKGNKIWYDEYYRVGIGLAMSLVFMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNX4</accession>
    <name>A0A4Q9LNX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0066p0060</name>
        <name evidence="6" type="ORF">CWI38_2022p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000066">
        <property type="protein sequence ID" value="TBU04969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002022">
        <property type="protein sequence ID" value="TBU10099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNX4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0066p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2022p0010"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="120" mass="13810" checksum="F37BF5280A6C1928" modified="2019-07-31" version="1">MLEEEKKIEVEYTQPETSYDVSVQLATTDKKLIQKACADFYTFALTHMPEMSKAIKLPTEKASITTRKSPCGEGTNTWSKYKMFVYKRVFHFITGSHTLEEIARFFNNSNVDVRVTLKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNZ2</accession>
    <name>A0A4Q9LNZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XRN-like 5'-3' exoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1994p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001994">
        <property type="protein sequence ID" value="TBU10138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNZ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1994p0010"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF71">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="663" mass="77316" checksum="D5131D7DDB444965" modified="2019-07-31" version="1">MGVPSLFRWLVEKYPDIIEKAPSKEQTDGLYLDFNGIIHNSSKPTAKESPKSENEIFENIFKRTSTMVEIVRPIELLYISIDGVAPRAKLYQQRGRRYRSAIETLESGKRFFAQKRDSNLEAAVQEAMDTVKSADILTEPIETEEIESSKNNMSFEHIKEELLDISSEDQEIFDSNAITPGTDFMENLENKIKKFIQYKISTDELWKGLTVIYNGSYVPGEGEQKIISFIRSQKKLRKNFRHTIYSPDADLIFLGLLLHEKNVKILREDVFYQEKEKKSFCRNCNNKGHSFSNCGSADFKNYLYTFVSVLRRHLETVFKEHIKRSFDCHRIIDDFVFLCFFAGNDFIPTLPCFDIRFEAIEKITQMQINNFQKYGKYLTNKSLVDFETLRTFLVTLAGEEDELYIKKTSYISMLRKKFNQPGIFERISLNTSKGRMLYYKAKMKVTNDSEIQQACRNYIEGLAWVFGYYYSGVKSWDWYYSYHFAPLARDLSRVSGFSPKFNLGKPLRPLEQIMVVIPPMSKNIVPEQLHTIFEDNKDMFPTTVKIDMFDKLLPWQGVVVLPFVNINSILQQVSKKISELNLKDTLRNIEGNEYIFIGDKNIFYTILDEMYTKCKLSADFGQRGFTGRAFPYCYSEFPGEKLTLIEGTEFENHAMCAIYKMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP08</accession>
    <name>A0A4Q9LP08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2046p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002046">
        <property type="protein sequence ID" value="TBU10074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2046p0020"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="54" mass="6514" checksum="00877760D5556A0B" modified="2019-07-31" version="1">MYINTNKMLDKLYTDELRECEMYLFFARSERSFLNLDEEIGSIDDEIKIITNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP41</accession>
    <name>A0A4Q9LP41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1931p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001931">
        <property type="protein sequence ID" value="TBU10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1931p0030"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15619" checksum="64560ACE2DED2C53" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKNKASFILQGGTTLEEPTNNINEESDLEEEIDVVVEMMERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPI4</accession>
    <name>A0A4Q9LPI4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1903p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001903">
        <property type="protein sequence ID" value="TBU10254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1903p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="27351" checksum="C267EDC4EC568A88" modified="2019-07-31" version="1" fragment="single">MCLIFFIFMKMSSTVKLFKKTHMNGFNLMYVEDINVFISKKSICGFCLSSDEYGFCSEENNILKICKGVHFFSRHQFICPNRNGNKKHFKLTTIMISFPNNICLKPSPNRLFLISKVPKRIYLHQNLYSIDFKYCLKTFSDFDYMIANLTIYKFLDLIYFSYIIDIYKDKNFYKVLKSYMIHIPGNILYHGINQVILYKERFDSTYFEWIISRMLDAYFEVNFFCVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN8</accession>
    <name>A0A4Q9LPN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1855p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001855">
        <property type="protein sequence ID" value="TBU10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1855p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="619" mass="72389" checksum="7D4312B6C6EFBBA1" modified="2019-07-31" version="1">MPKKENITSPVNNNNATNKKNSSDDKNSMIEQQSESDIKEDKKNQNSEEKSDIKKDVNITGKTIINTKKNINDEDINNQEIQPSEYQNENPERKLLFENIVAQNDPIINIEYNNCSDIDNEYSNISSSNIDDEDDKSTYIEEETYNEIEYLSPEILNNCHNEDSNLSSSHERFFRERRCRVRTLTNMDTRDSLFNININGFFQRSNFSSRVYPESTIEPFSSPIEERELSDINLSSEHEPPIYSNTIENQSNNNNIFETLPQSIRFRTNRNIRNREHIRSRILNYFDRSISNRSLANNRRNRNTDEDEQNTFIPYISRLQNNLDNFYRSLDSIEGKYKNKFSGNSVFVNICESESDEYTKVRHPRRQKKANSLPAKNETNVSNQSGSFEVEDSSEGCMRQYACSNCCNKKVSDEKYKYNDQHKNDMEEHIDHDEMIDSDSEYSRQIHLWEYYRKYGKFAPEDNPSDISSNKNNQTQNNFDCKKDCTTPESKEISKPFSNNQSNSEFNKQSPKKQTWECSKKENEMTNDSSNTKKNSKQTKQNEKKKQENSETNQGDFNMPIHNMTWDNDITEIATEPQNNSDPCEEESEECSEFNEDSGYDAPNTDFDSEGEYYAGDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPV5</accession>
    <name>A0A4Q9LPV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1802p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001802">
        <property type="protein sequence ID" value="TBU10384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1802p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="24150" checksum="00160F5F399BEF8B" modified="2019-07-31" version="1">MLYKLIKEQYIGPQINHHYNFLMANWIYNLLSGNTVTEELKDDLVFVDETIHMNIETDTEVNLLIGDKVLLKNNFDMNTKTKRAPFDYFYDDSVFTVTNGFSSNMIELENVNAKKEFPSLPFLLKSLKNLEKVYLNGDHIYKILFLKNFSQFIAPKTLKVVSIISKYSMKSCQNFDFDTDIIEIYLWVIIFQMELLEIYFLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ92</accession>
    <name>A0A4Q9LQ92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit epsilon of translation initiation factor 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1809p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001809">
        <property type="protein sequence ID" value="TBU10377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ92"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1809p0010"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="551" mass="64099" checksum="38903E3BEE984641" modified="2019-07-31" version="1">MRRLKNNSVLLICDYYNEHVIPIEMINSKKNIALFPISNVPLIEYIVKMLEDSKFTDVYLAAGVSLPVLCEYFKNSKNRCINIKFVSIDGKNFADFMRELDEKDVEVENLLVMYANHFTTLNLKKLFTFHKTAVMKDSNVLMTIFLSKKENTDKKMVMLGRTQEKGILFYDRVTNNCDFTEAFYGAIEAHTHLDFCTNFNSPGIFVIDHRFFPLFTEHFDFKTIEDFLIGILAFNVYEYKILYYECENTHVDSLEKISNLSLKNSVYSKVISTVEDYFQFNDDIRKGKVHSFELEKFIISSNQDNILKYKKNNGNYILENFYENKTNVVDSVIGFQTKIKESSLVNSTVFGNNCEFEGKADKCIIWDGLKFSGEFENSILVCKEDSSLVQFSRDYTVEIIEQEEDITEKNPKSFFDDFLTYLDINVVAVDLNKIDFEDARKQISLLRIVWNASTFDILEGFGMFFVKLLDVNDVDNSTIAASFLFPLLYGWTEGPREQDALLASIFELLKEGDREIRKEVIIKYGFLLMEDGFVSRDVVKKYRILIKKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ0</accession>
    <name>A0A4Q9LQJ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1582p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001582">
        <property type="protein sequence ID" value="TBU10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1582p0010"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="48803" checksum="703278C10FAF7714" modified="2019-07-31" version="1">MEKLAIDTNADSVYTNNSLLTDNLEFFEPFEELNSNFLILERHSRTKYNVNIILQYPHAISIITNHKEKRRKGTGLSGWGLGRKIDIVALQEMRWTGKRIMNKKEYSLYYSYTTEEEKEAFYDPLGKLYDDCFRNDIKFLLEDMNAKIGKDSAYHSFRLLDVSVNRNVNLDNDHFLLVARLKARTSHTRNQKRIRSVRYNTCMLKKEKRKKIYESKADEIPVFPLDLSEVLEEMKGLMKNNEAYNLMIQKKRDARNEEKRIHRAKKRKSMMTQMEPIQKYSTKHLSREIFRTMNDNRRAFISRTKNFISKMDEIINQVDKDNVFDELDDTDSYKDIRPSNEEVHKASDMERRENSCLFDSQNGNTLNCENYRGKSLLNTTYKVLSRNIFIRLLFMREHHRRIPIRLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK4</accession>
    <name>A0A4Q9LQK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1571p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001571">
        <property type="protein sequence ID" value="TBU10748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1571p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="17585" checksum="2854D13A709B1A56" modified="2019-07-31" version="1" fragment="single">IFTEYQSRIYSKHHDTIFSTKNQATECFNSENNFNFVKSVNGINITTLYSEDFNKEIFFRTNLLNYEIFCIKIFEIASQNNTILSSYFFKNNLFIRILEIFSRNYTKRNSLYSYISDIFINSDKKFLEKLTNLYYNEVNRILNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQU5</accession>
    <name>A0A4Q9LQU5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_1497p0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="PITK01001497">
        <property type="protein sequence ID" value="TBU10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQU5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1497p0010"/>
    <dbReference type="OrthoDB" id="2196365at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="349"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU10879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="675" mass="79945" checksum="50F8BF0E4F6C78F3" modified="2019-07-31" version="1">MKLFGTKKISERKLFRILVWLSITTRFFFITFPFSLIQEEAYFIKLARGLIERQFKYDLQPPLGKLIISFLLFWGKSNFSVLSEIGMPTVFHKASYVLLRGVSVILSIFVILMTYKILLRILEPWKAFLVSLLVLFENLYQMHFKFITADPYSLFSMVCSFYFFSEFYYERKYVYLFLVGIFCGLNISSKLIGISFWLAVSIYILVEIFTAFYNPDIKFRSIFVYFMNFVFGMIVVPFLIYIASFYIYFLFQTEFTNEARNLSLHFQSDLKNFPIEQVDKYVMDHSILTLINTENKVYLNSSDEYLTTGSKQQIVSGDQNKDEYALWRIMKVHNIEESNQEPNNEGIDSKFIKNGDSVKIIHLMTDKYLHSHEINTENSKDKKFFEATAYGSGSKNMTDENDYWVVECDTEFLQCRTSLLQLKHHMTHSYLGIRKLENNTYEAHTSRDGRKGMRNFYIEDNRNEEIHKISKDIKSKEKIENYKNLTFFQKFIELNSKIFEQTNNLDNKNISIISPWKWLFSIKGNIHYFLKTDHYSLDMTNNNKNVLIVPYNILTHVFSSIIAILFPLFLFFNHISLQRYRKGIFINFFIIFIYISYLFNYLPFIFTSSQYYHTNYLFSLYFSLLLIGISISIFGENLLLIFVISNSFVFFNNLNVNGTIISYEECLRQEICSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQY6</accession>
    <name>A0A4Q9LQY6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1487p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001487">
        <property type="protein sequence ID" value="TBU10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1487p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="346" mass="39127" checksum="B2F7F32E44D7BBAE" modified="2019-07-31" version="1">MDKVKAIFTEFKNVKTFDNYLNRGSLEEIGERLSDLKRRLSWVERFIDNPPVRRHRSVFAETLEARGSKGTSVKRVIQREGRRRLDVTVESGIDPETSVRICTESYGNLRLLTLNVNSYGSKREEILCLQETLRYTGSSQNEEKYDRGLILAVRRKLDLTLSSVEVHPNFLAGSVCGKKASGGWFKLLVVNVYIPSKCSLYGNRAETLEALGSFLVSENKKNSLDDILVMNDWNMILEEAARFLTKWDISDHLSVTVDGLNYRVPSLLFADDTVLFGDYVAALQLKMRINIDKCGFLIIPCLTGNVIIGEKAVPVLAAFRECDIQSLYEKAAMSRRERGLLKPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRH5</accession>
    <name>A0A4Q9LRH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1368p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001368">
        <property type="protein sequence ID" value="TBU11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1368p0010"/>
    <dbReference type="OrthoDB" id="2201046at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="13946" checksum="43EFF051D926BF4F" modified="2019-07-31" version="1" fragment="single">MIVLCFIRSIFFTEIHKSSVQDKCQNINESDDREYRKDDIEKSQEKNSEKRNLDQGYKIRETYVEENKPNQVLRLKAISNIPTDEGNIGKNDLTMNTYNNCEAIPARNTYLFQNNYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI9</accession>
    <name>A0A4Q9LRI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA polymerase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1498p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001498">
        <property type="protein sequence ID" value="TBU10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1498p0010"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="353" mass="40666" checksum="6AE0AFC848570552" modified="2019-07-31" version="1">MIIPVRCFTCGKEISSKWEPYVDLLGQGRTECEALDILGLGRKCCRRMLLCHEDIIEKVLNYDVFQNLSQNSNVFAMLSKNQIFELKEAFGLLDTNNDGIISKEDLKTFLSSIGDPFTESEIDEMMEEAGNEMSFMMFLTLVGEKLSCTDEESVILHAFKDFDENRNGFVEEKVLKKWLTQEGDKMCEEDVDFLLKDCCENGMVDYKKLTEIIKHGEVLKKEEILGLIYMCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESCERASMGVIMRAEMHEEPIPPLKEAKREEDEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP9</accession>
    <name>A0A4Q9LRP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1935p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001935">
        <property type="protein sequence ID" value="TBU10215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1935p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="35665" checksum="0553B1E2EF15AE78" modified="2019-07-31" version="1" fragment="single">KEDRGNKENKKIKEDEKIEENKKSKENRESKKIKKDREITDKKDKKNSLFLENSNLLFNKEGSNLNNEILFDPMERKTKGVEKGKSNKKKIDDKKVEGDIKTDETVETSKSITKKGGKKEKTNASNTVKKEKKELKQNLVEEKKEDENKESKKKSNETTKTSKKAKSTDENKDSKKAKSSSKKEVNELNTKTEEETKNVKSKPVKETKKKSNEPTKEPKNVKSTTTEKKNKKEGPVIEKVTLEVAEVVSVPVKKVDPTKKEAKKAGEHKNEKAKSESKKTASTGKEKKKVSDDNKNKVIDSSKSKKEVKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS53</accession>
    <name>A0A4Q9LS53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1234p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001234">
        <property type="protein sequence ID" value="TBU11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1234p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="45728" checksum="D5922D231AFB4569" modified="2019-07-31" version="1">MIVYIESDDRYFEAEVYGGEVSKYKVNIGNMEGSVSKGKINRSKDKDGRGSNKGKGKDNTFLNFNIINNTPLNIYANNKPPLVNTTDIYTFLVNSTDDNTPLITLPIITPFFPTTHIINSPFPSIPYSIDNLEINSNICYNRNNRRDMCDSKNYSIEDTGNNTIDTNKSSTNTTINTNTTTFTNNTNNNNTITKILLKSDDKSEISRYYEDDCSIEDFVNELGVLSKEIMRWLLKSFYVEIQSLKNIVMSVVDQILLIRILDMLSDWENIGFRFIRDCLRISYLEKVGYIKLLNNFPLFFFIVHIYRIYSYYYIMYLKGLQIPMNVEAYIHRIYSYYHIMYHKGLQIPMNVEAYIHRIYSYYHVMYLKGLQIPMNVEAYIQNLWLLSYDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS88</accession>
    <name>A0A4Q9LS88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1805p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001805">
        <property type="protein sequence ID" value="TBU10380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1805p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13718" checksum="35474C6FAD32CB71" modified="2019-07-31" version="1" fragment="single">MEKINDMEFNNDLERENKFKEIVSKHIKTLNLEKPNYENKEMFYTKEEMDRFNNIVLKTNEEKKQKEIARNDKNYKKNKENKSKKNKKYVQIDDYVEGSSKNEIKKQKDKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC0</accession>
    <name>A0A4Q9LSC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1346p0030</name>
        <name evidence="2" type="ORF">CWI38_2013p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002013">
        <property type="protein sequence ID" value="TBU10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001346">
        <property type="protein sequence ID" value="TBU11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1346p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2013p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120565" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9192" checksum="E0237D610F6390B4" modified="2019-07-31" version="1">MNYISFIVLIVLVVSKPECIGSKTCKTKECQTPSTGTIVVQASEPKSKNTCESNNSDNDKCKPKDKCKIVSKNDCYEDIPLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP5</accession>
    <name>A0A4Q9LSP5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1667p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001667">
        <property type="protein sequence ID" value="TBU10585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1667p0030"/>
    <dbReference type="OrthoDB" id="2194264at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="Zn_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon 15" evidence="1">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="12793" checksum="6A1F15D94473850D" modified="2019-07-31" version="1">MCGVILCGITKKSKILSIPPTNFPSAPSNVICPFCTFRGNLVYRRNDVWYTFFFIPIYPVYFGDPYVSCVSCQTQLGGAGASFCKKCRSATPLGFNYCVMCGDSLEKQRTALVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY2</accession>
    <name>A0A4Q9LSY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1305p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001305">
        <property type="protein sequence ID" value="TBU11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1305p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020736917" evidence="1">
        <location>
            <begin position="26"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="539" mass="63236" checksum="9813246B5FD672FA" modified="2019-07-31" version="1">MMVLSSYKKMLFFVLWSFLFCSQDAQNNRKFRSASKKGKDERIYFTREFWRTGTQFSDRGGNRSGSPQLLSIQIEDGVYPKEDQRSSYTFERGSNAGVSADVFDSNVNTFLKSGELVGTPNGVPRHCYHSTYKQPHIKSLKKPLVSKNIVTEEFRKQSGLHQTIQGVFMSVLSYKDDSQSDLPQIDMFLNNQYFLYVFFEQNTETNYTETNYTEFIKNICFIERKLIETQPNLIASFRMIFEEEIDKISIFTKYDEIIARSTFLISLKRFFKERLESIDVSKRCFISVFLAMKSIESILLLTRERLYTDNLRLIKKSNHSIYKTLNDVLDKNSNTIIEIIFVVCSFGLNLNDDYLKILNIMSIGIKRRNVNSIVSKLKSSTNLDIDFITDLGFLFESNEIKKIVRAYNSTASFDRNCLNTETFSQNFSSELEKILNEKNFIIQIIEYYSGIFSDTKLQFFNSTVRPKYVDKQYNSLITRSKELFRRNDQDTDSIQDLQKLRLHAFSLFHFVLNYCYNNDINSKNFLRLLETEFKKLMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY4</accession>
    <name>A0A4Q9LSY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylinositol 4-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1609p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001609">
        <property type="protein sequence ID" value="TBU10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LSY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1609p0010"/>
    <dbReference type="OrthoDB" id="10550081at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1358" mass="159446" checksum="06834A680AE6189C" modified="2019-07-31" version="1" fragment="single">MQFDEYKEYKSTLNNQKISINFRFNKKVTTDDLKSALNHFTYEDPFFIFLLLKNTLYTTDTQMLQTTDKNLYQIFLDSFTLLLNTHLYEIIINDILTLSFTTPLCYSLKSALLEIFISNYSFLHIEEFTSLIETLSTTIKSSTFNEIINYQNDEPLMNAMLDTFLLTLSLIAKYLETRKILDLSITNHHLYSFSLSLYNEMLMLLNTSNFMEKDIVFIFINSFIINTFTEGTCINQIKDILLSHNLMIGEDSMIEIQYRIIYTMGCLSPKDFLYVLDLIFTTDCIIFMAKRKAHSLINRITNLFIITEQENNYKTYKGCKKNHNILTDEEKEAKDYETIKEFKEKLNLKLKQEISKEIKNDANYEENEKTKEEIKEEIFQKNEKQFEIPLCIKSKLKNKNFTKKCIKTENIKEELLLCISSQNLFTIYRKAFFYISSLTKYKNLYSQNFLYFISLKPLPFHFPEINNFFLKLTTQTSPEYYANFLLKNEFSFPLYTFLNSLPPEYPLNFYYHVFKNLKKDNLPVTDTPFNNTLYIPTKTDFHILDFLNFFLEKRDKILIQLLNTLPYIPPYKPFYPVIYDVWIFILKHNFLKNMTFFFLKTPALVKMADSLQHPSSKLQIKIPFILKKTPKPPHLTFLTILYFSEKNKISNFNYTGVIEYITDDKTLRFLKEEVEELIEQIHLEEGVIKGKFNFIDKEGLEALEREKGCYTVIKVNNTTTYNNTPINNPNITNTSDNTPITTTLINNTPVITFAFNNPLPMPFNLSYAYTLLSLGTNTSSYKTTLIISLKILKILLCKDNTLLYNIKLHIYFSEIFKTLKARNQFKDTEDVFISYLSFYKTILSEISGNSPIFYNYVVLFIADITLFGKDYLTLGFTSFKDLYSYVEITMKKIEDFSNEVCELRGVKDSRYVLEGVKYSRYVLEGVNDSRYVLEGVKDMVWELEGVNKYKDIQQGVNNITNQQQGVNTLTNQQQGVNNITNQQQGVNNITNQQQGVNYSIDVTSDIFFLIDVVYLNLYNSNTLLSVIQLLKTLLATTFNYKTLYVLVRICNTLYLPKSIVLPYLKRVLRVDIDFKIDPVIFRKLSIETEGFFKFFFDNICVTTGESITNNNTTYNNTSSLWYNRYSGYKGVNTGNRIIESITLDNWYSYYKRYPLNINLPMTNNKTPLITNIDFEASLKHTVNNNTLDDKDLTLIYNMYRRKGVISFIRNNSKIFNYLNYSIFVDNSMSVMDCITVIYRSLNREHIKIALEVLKTKQNIRFYIPQLIQVLRREEVRCDVFILLIHLSNNNILCHELLLNLKCNISEENGNKKNLRGVHTNKSNVFKKCMDDLILGIGEKEVLLYEKQVKFYKNLNSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT37</accession>
    <name>A0A4Q9LT37_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit epsilon of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1060p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001060">
        <property type="protein sequence ID" value="TBU11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT37"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1060p0010"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="745" mass="84119" checksum="2374F91969683BB2" modified="2019-07-31" version="1">MINILTDDLGRILTLPKEEQEFQIMQGKEVTKANSLVIKEISALLSTSLGPNGLDKILQSKDGDITVTNDGATILQNMEMTENPISRLIVQLSQSQDEEIGDGTTSVVILANALLTQALLLIEKNIHPIRIIEGYEKACEMVVEYLEKISDSILDNPYFYMSKAASTTLNSKIVSKYNDYFSKIAVNTILKVCDMKRRDVDFDLIKISTKIGKDLGDTILVDGVVINKEFSHLQMRKEIKNAKIALLSCPFEPPKIKTKHTLEISSPESYKKLQEYEKETFLEMISSLKRCGADLVICQWGFDDEANSLLMENDLPAIRWVGGSEMELIAVHTRGSIISRFEDLRPEDLGRGSVKELSLGTENEKIIVIENNAKKNHSCDLTKEFDGEDENLSNKIDTALKNKDLVQETATDSVKQNTVTILIRGCNKMVLEEAERSLHDALCTVRNLLVNDKIVYGGGSCELACSLFLKKKSMESSDILFDILEGFSVSLEEIPMCLARNSDLDAVEYISDLKKKQRETGCVSLGVDCMGNNEIDMKKNFVFDSLKSKSHLFRMATQMETNSSNNDRESNCKDYRRLFYTLDCLNVSNKLPNVKRGADRRSKLTLEIKESLRTNVYFVCTKTPYEPAEWVNCTFNVDVATIGGDNNDKNFVFLDEVGLSVVTRPRNCFVSKKYLPPYSPFLNLIENAFSVWKDKVIRGDARTEPQLRILIREKFNEISVEHCSSFYRKMVGYLQKAEVGQVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT68</accession>
    <name>A0A4Q9LT68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1032p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001032">
        <property type="protein sequence ID" value="TBU11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1032p0010"/>
    <dbReference type="OrthoDB" id="2194933at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="24089" checksum="59647AE27782A830" modified="2019-07-31" version="1">MEWITEKEAETLIALLKIRRENRIKYIGNNGYKYKSRRQLAMLNRIYNITNYPSTDTRNDIAVLLDIPQRSVQIWFQNTRQSMKDPKFVSSTDQKMKSILSGFNIISSKILKSTSEFSFKFHDSYATMNYEGNSFDISAFNLIKVYQEVQSEDYKLKTPPLKQVYYEEDGVKMENTKNNTSLISQEGTTLDLEEETVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT81</accession>
    <name>A0A4Q9LT81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1546p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001546">
        <property type="protein sequence ID" value="TBU10795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1546p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="19196" checksum="3B0E244458566287" modified="2019-07-31" version="1">MLEEFEDFRIIKNETMIFNKKNCIIFNKKKQNNEKNLNENLESLMKNYNENQMIKSEIDDKISIETEFPFNPILKSNKIGGHISTELYYKYLIVKILKILDIHINLKIIVLGEVCEIQDFFEGFFIFLEKIEASKSKCEFICQNDKEIILINGLVVYENNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX0</accession>
    <name>A0A4Q9LTX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1048p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001048">
        <property type="protein sequence ID" value="TBU11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1048p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="497" mass="59564" checksum="FBBFE96D4AD9F79A" modified="2019-07-31" version="1" fragment="single">MNAVIYMLNLTYCTIQRLKKKESIEFDLLYACNINDSITNNYNRDKGELTNIYTLYSEEKNVLYECEGLHRFINDLFLCPNGKDEFKHFELRMVKISFPKNICLIPSTENLIPISKCRDKIYLHQKLYFIDFKYCLQLFSNFDSMNTDVPIDKLLDVLYFSYIVGIYGDKNFYKILKGYMIHASGNTLYNGINQVLQYKERFSTNYFNWIISRMIEIFYELNFYYIEDISKGKIGRRFDEKLIEDKKFNISSYIIEKIYENKIEENNIKLLRFLLFFKEIEEIYLIDIDFVHVKKMFCLRKIFSRNIDAVTISQKTKIGLVLLYLNNIAVFKNIKKLEIRRTILTENNMRLLANFTFLEHLILSDIIIDQRQYFFPKYLIGKLLNLKILNIRTSFIFLYANLVVMFPNLTQLFLTLNKTQDFDNFMVLPCLEAYNLLFKRIGFRFVSANLKDFFNKIYNLKNLEDITITSETISPIYNYNNISHQQYYLTLKRLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY0</accession>
    <name>A0A4Q9LTY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1042p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001042">
        <property type="protein sequence ID" value="TBU11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1042p0020"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="21992" checksum="C493B24993CDCD0E" modified="2019-07-31" version="1" fragment="single">MTADILKDKNKVKEIKSENLNENQVREMKNSNTEVRDNKNLKDKEARDNGVRDNGVRDNGIRDNGVRDKNKVQEARDNINVDNSSSDIDRPTESRERRFIFMKEEDNDIKIEHKQNIEDDDNMLVLKGKPVSMQRRVTIARGPGGIPILREIIIIETEASISSILRVLGVLFLYALLFQTVFSLWNKFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB2</accession>
    <name>A0A4Q9LUB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0981p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000981">
        <property type="protein sequence ID" value="TBU11917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0981p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020633292" evidence="1">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="452" mass="54245" checksum="26868E01E58BADE7" modified="2019-07-31" version="1">MKFLRKFYCLVLLYLVQFVFDSSPFNDPHIKYPYEEISKKIKLIFEKVLPKYITEYTNNELYTINLFGLDLSLNRFYIPDYISSQMYSENRIFFTEFICSKEGVLIENRNKLLFEILKSYRNEQKKINLRAYNQINGRDLEFEFISKTNTFEIVNSKSSISDLRNEILEKLKKYESHVSEHIKNKIFKIYIITPFLLKLIDINVLEYTIKELLQIHVIEKDTVILFSRQINDVQMSINKNISYNHFYQLLRKANSTGNFSVNIEKRILFNKNTYEVYQDNVSDQNDIQNGKIDDLKSRNISTISNLDLKDPMSLIQPVSKPNSDAQILPFLDQSLSFLDLSSSEERIIYREFSLFRINYIFRIFNAEIFRIKLYFQMEQNGRFRYFTLDSIFPRTKQFNQVSTIQYELATQNLQFKYYDGINHRRDSIAIFFYALNHRFEDEIESLIRLSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD3</accession>
    <name>A0A4Q9LUD3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1243p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001243">
        <property type="protein sequence ID" value="TBU11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1243p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="21539" checksum="F9486EBC1F2AEEBF" modified="2019-07-31" version="1">MIKFKLKEENIEVRRKKYFLLKHAFTKLDKNIMRSDYTCMISALLDAERETYFKEENGGNNSFFDTIKRVKDRFIRNFSCCGCTFTDFDCYVKHTYEFHDNRSEDLKNEIDKDVLYHAHKSNNLSFDIKKNESADFYSNQEMKKKYPCLIKDCYKSYKNLNGLKYHMIHHHNNEEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE6</accession>
    <name>A0A4Q9LUE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0964p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000964">
        <property type="protein sequence ID" value="TBU11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0964p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020233400" evidence="3">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="209" mass="23907" checksum="0E1FC8C2A7D42AEB" modified="2019-07-31" version="1">MLKFIFYCSIILNLFVFARVDIEENPRRSTPRDSKTEDPKEDTTNAGSAPKSSSKNPDINKVLELIGMVGGENTAKLRLLKKVNIDTFLLKSEGTKEVSDDAIEFDLTDELKEVSSLDKNNTFEIEFNKNKLPESSESPKLYFFELKETNGQTHESGRFYFDVKDRKYKLLPKQADPSWFSRYKTVIFTVLGVLIIAVLVFAVLKFLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ3</accession>
    <name>A0A4Q9LUJ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0805p0020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000805">
        <property type="protein sequence ID" value="TBU12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0805p0020"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="618" mass="70409" checksum="C0981CF7A359F7C3" modified="2019-07-31" version="1">MSHFYNIKNKEGLNMGEILSRLKDCFRKSYLKEITMVGLDGAGKTTILYQMKISSTVETIPTIGFNVESFNVGKTKFNVWDIGGQDAIRPLWNHYVEMSRGIIFVVDIIDSNRWKSAGKALGDVVRGMERKPVLILANKADDPNDPCLNQKVQTMVEDLGVKDMNIIYEVFHCSAIQGPNNPNPLERLVPAFEWIGNTLGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILSLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEINTASLPESVNVYKYLRIIKDSRSNSTFERLCHTRFKAKKSFPLINQHSISLINDQIGVLRLDDAVRVVLVKNEMYLSLAIVGKIFCYFQDRNLFWGAEQLDVRKCSSINTPDGIMKQILENEHAEIRVDIRLKTDVKIRNNRLDVFTFDKKKNKITLIELGITSQDLLQIKTVKTISFNQPREPESDPNAKASWKKATMCVIQKDSMHYEPTTALKQGENDENGGKELKTKNNAPPISKGGTRYEEMTINIKEESDLEEEAIVVKEVKSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV05</accession>
    <name>A0A4Q9LV05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0766p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000766">
        <property type="protein sequence ID" value="TBU12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0766p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="61" mass="7449" checksum="16A0A3EA63712768" modified="2019-07-31" version="1">MKKRFIKQKVLQTKEQTKLKKYLESEKKEDSILEEEWKDIKDNNYSSSPFKSELFQSFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV33</accession>
    <name>A0A4Q9LV33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0722p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000722">
        <property type="protein sequence ID" value="TBU12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0722p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="265" mass="31588" checksum="72334268FB28228E" modified="2019-07-31" version="1">MKKICLYELDSTHISFKNLLLVISNHLERIELFSSKIDIEMLNFLNQKDILVSLKSIYFLNQINKISECAFTGFNNNLEVSFSKNLNDFIVLKPEHENMTLFGIFHTIFNKNFRKNIILSENFEYSFDSNESNVNIDLDSFKNDEMVKLFYIVSNNNIYIEKTIYFVNECNKKDSFSLIYNGIKESDFEFFKLWDRPIQSIRIYGCFLETDDLFQIIRFKSLKTMHIENSILKNDLKNPIFHDNNIETVFLKVTLFTIWIYFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA5</accession>
    <name>A0A4Q9LVA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0856p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000856">
        <property type="protein sequence ID" value="TBU12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0856p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="14097" checksum="D4E65D67656DD7C4" modified="2019-07-31" version="1">MEYKTQSTQQHMTPMKYVEVSNIRNEQVQSEKVTTLQRISLSLKSFFVKIKEKIRDMWKAVYNKIKKKKEETNLEKENEEEFSTNSKYINSGDFNSNNSHNINTNESHVCLDKEVVNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC6</accession>
    <name>A0A4Q9LVC6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1124p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001124">
        <property type="protein sequence ID" value="TBU11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1124p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="62395" checksum="119B5E6C356C20D1" modified="2019-07-31" version="1">MNSSIITPSSQKEAEEGHHNQNMKSNKFPRSEFIVHNEETNLEISNKDSLKNSRPIENKYNNLVIIGNVIYPIIYDGNLTLEIQFTSSLLQSDLREAKNKEDVSKILSQIESYNYIHNLYMNCTNIIFFATMNSSHVLNESLQILKEELWDIIHPSQVKQGLDLKNFLRVDFNTEFIFFDKDNFSLAMYLEDFNINSNFNELLDVGKKLIEYEIFFYSSLSTEELIKNISINNYYQIISALKNTKMDLIFPELKYIYEIQEFKNVNLLKKGYVLYVHYICAVLKHLSDIVIKNQSKNRKNKECSIKSNKITIITKKKITFYSRKLIADLLFGLNHDSEKIETYRILNTISYYSANITKKNKYLHKNFFVIMMRFLYRFLFDSECKVNKETNQDLIIGMICDLHNRPADLILSRRISEIFLKNFCQNFFLEKCSIGLMELEFKIQGIAIIKTITTISSESKRIIEKLNNLKEPQTHKSILLETLIEFEFIMSYTDRKLLPTDFNLLEFHAGKSYKTVLDTTMHQFKEHYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD6</accession>
    <name>A0A4Q9LVD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0715p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000715">
        <property type="protein sequence ID" value="TBU12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0715p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38389" checksum="D2978A7283A461BE" modified="2019-07-31" version="1">MGKYQKATYIEESEFLDKIFEFSQKLISVEKTIYYSFTKNDMILKAEILNFVNTINEILNKKLYFFMCDLIVFSLINREDFRSKLQDGYILYTSFLLEVIESQIEKIIENTSKSIKVPLNTTEKNDNTYKLEKGFLHIRLLVSKILFVMKDNNYSANVYFPQSLLSFFSSLTIQTLDVIESPLFKVFIDLLFPLNFYGGEKFAISSLNAIFDLITKLISKIPTKRTSILQTARNILIGYSDEKLVHFSFETLNFLLQKYKNEVIQDYFSRLNNKYKTLYCEENIPSKESDVKNIYKVLIQSQMCLYSYKVYLPEYSLYLVKDSVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL1</accession>
    <name>A0A4Q9LVL1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0687p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000687">
        <property type="protein sequence ID" value="TBU12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0687p0020"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="33169" checksum="ADD331B02078B41D" modified="2019-07-31" version="1">MNKKLYKSKNKKHYQDSRLTSYLKESKEYFKESKNNTIYSDIIRFSFCISYAFIFYAVFIKIQSLEFLENFIKILYLFTLILSYLISKCTTHKETVRLLSITLLSIYVLSPLLQKLTPEISTDTIYLNYIISMFINCIDTVRYAILSSEIQVDRFKINKNVPLKLEETIHIKSKKRPVNVIGANTATYGSILLCSRLKNIYQVNFLLTFSFFWFVLSVNLRERYLFHKKYILIILFHIVTSVIFFLISMELLYIFIALQIFVSLSAFTTVYILNKNIRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL6</accession>
    <name>A0A4Q9LVL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1078p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001078">
        <property type="protein sequence ID" value="TBU11695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1078p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020988245" evidence="2">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="311" mass="35676" checksum="E54996B490AD1642" modified="2019-07-31" version="1">MNNIFLWFAAIFGSGSSINREVGSEINQLPNEESEKRTNKEDSLKSESSEMLSTENSTGGARVNYKKSNNLFSSEPFCHELNEGFSRLKTSEEKYINPNRNFSFPSQNHYSETSCHESNAQFTCPKSSPNHFRYDTDTKSLFDSSTYEYFRINHYSKKMSRSCSRSLFNERNYSSSLHKVVSGKIGNYHYAIPKKCIRDLFDKNLTKSEILPEKEQDCASNSESLNSKDASSPNKKPTQSMLLVDIFRRKHIQESSKLSEEKVLSQNPKLSALLSQPIQIDRHVHSKDSKQNTAIREYPLLTQILSRNESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ3</accession>
    <name>A0A4Q9LVQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0630p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000630">
        <property type="protein sequence ID" value="TBU12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0630p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020831628" evidence="2">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="15232" checksum="C32413F96901C538" modified="2019-07-31" version="1">MKFLDILLCFVACIFFASRFSYADESDSSNSTSSSNSTSTSGGSESSSGGSSSGDATSQGSDGGNQTSSSTGNNATSTNATGTNATGANATGNKTNVDKDNCVKIDGETIEDKPGRIVYCGRSKRTDDCALPERTPGTTKDYSRTCYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW64</accession>
    <name>A0A4Q9LW64_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0011p0090</name>
        <name evidence="9" type="ORF">CWI38_0272p0060</name>
        <name evidence="8" type="ORF">CWI38_0569p0010</name>
        <name evidence="7" type="ORF">CWI38_1072p0030</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001072">
        <property type="protein sequence ID" value="TBU11711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000569">
        <property type="protein sequence ID" value="TBU12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000272">
        <property type="protein sequence ID" value="TBU17662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0272p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0569p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1072p0030"/>
    <dbReference type="OrthoDB" id="2193583at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU17662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12224" checksum="4F2B727972AA5ABF" modified="2019-07-31" version="1">MSADSIKRLIQCEKEAKESINNARKERDTLKIKAKKDALEIIERLKVQKNQELTDLEAENAKYLEKIRKELYEKYEDDSKKYENVLDSKTDLVESIVQFITGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH1</accession>
    <name>A0A4Q9LWH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative spore wall protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0536p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000536">
        <property type="protein sequence ID" value="TBU13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0536p0030"/>
    <dbReference type="OrthoDB" id="2191916at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24560" checksum="2D1613E64421611D" modified="2019-07-31" version="1">MDYKYTKVSEEHEKLEQKYRLLRDFLTVYEASCDKIMTYEHGGKTYKNVMEALEVVGERVNLQAFKVNNIYEQASLVVEKMADIHASDALNKTASDYSKALGEIGHKKTIMNGKFEDQMMELQKIKSRTAFIDKQRNITKNIRFDLEKAYKNDPDGVNIPEDLKNSFQAHLTDTEKYMREFVENKDVIGVINGCVEAQKTFHSAALEALKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ3</accession>
    <name>A0A4Q9LWJ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0909p0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000909">
        <property type="protein sequence ID" value="TBU12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LWJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0909p0010"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="41"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="686"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="883"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1147"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1315"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1545" mass="178452" checksum="38DD93CA6FFFF453" modified="2019-07-31" version="1">MTEQKTVDKNINKLNQQKSKDPTDENQCSSQINSFPLIEEKILKLWKENKAFETSNILSADRPPYIFYEGPPFATGLPHYGHILASTIKDTVTRFYYQKGYHVTRNFGWDCHGLPVEYEIDKKLNISTREEIIEMGIDKYNQKCREIVLMYSTEWEKIICRLGRWISFKNGYRTMDTPFMESVWNIFKMLYDKDLIYRGYRVMPFSTACSTPLSNFEANQNYKEVSDPSILVKFPLLKPFHHKNVSLLAWTTTPWTLPSNCALLVNTTITYGIFEYESEFLIMSVDRLSSFNLKFPENLNSKKTGKSEDLKIKKTGNFNLNKSEDLNPNKSNKSEDSNLSSLSKPEDLNLSSLSKSEDLNPNNINNHSEHIPDSKFIATFLGEDLLNLEYEPPFSNFINLREKGYFKVYPADFVSNQDGTGIVHCAPAFGEEDYKAFVKNNLIKENDIVPCPINDKGKFTSQIPQYQDKYVKEADKLIIKDIKNKILQNNRITHRYPFCWRSDTPLIYKLVPNRFVKVKQFTNQLLTNNELINWIPPSIKYKKFHNWLQNAKDWSISRNRFWGTPLPLWTNKTYTSIICIGSIKELEEYIYKYGDTKTKEKYKTREYVSGSEGEGFSKEINKKINKEINNIKGQEEIIKEINDTNNNNNTNTNTNTNANNNSTNTNTDTNTTTNTNTTTNTNPNPTNTTTNTTINDIHREFIDDIVFIINGVEYRRVDEVLDCWFESGSMPYAQNHWPFTNKNINKEFPADFIGEGADQTRGWFYTLHVISSLLFNKPSFKNVIVNGIVLAEDGRKMSKRLQNYPDPSYVINRYGSDSLRMYLVSSPVVEAENLRFNENGVKEILKNLIIPWHNALNFYRQCSKDIIDGGIVGGNVGDILEGSNYKDSSINDNSINDNSIKDSSIKDSEQQGVNTSTNKQHPVNTTPNNYHPVNTTPNNYHPLNTTPNNYHPLNTTPNNYHPVNNTPNNYHPVNNTPNNYHPTPNTNNNPMDHWILTSFNNLVYNITIKMNNYIINGVLNYILKFIDDLTNWYIRINRVELKKGKLEVLRYILINLSVIMGPFTPFYSEYCYQEIMGYKSNKDSNKEGVKDKDNLVCNKEGVKYKDSNKEGVNDKDSNKNRDSNSNSNIKDSNKEGVKDMDNLVCNKEGVKDSNNNNTGNNNPTNTNNNNPTNTNTNIFSSVHYLMYPVVEEFKLHSFEKAKEVIEGVRSMRVFYNISLKTPLNNMKVICKEEYWKELLEYKGVIMRECNILEMGMEVEESFCIKVVVKPNFKEINRRCNSNGGDNSIYDNKGELNKELNKELNKGELNKELNKELNNKPNNKKPNTTNNTNNNKPNTTNNTTNNTTNNTDNRKDVGVKIQAIRNMTDEEIKGVISSGKVVKDSIVIFDDELIVDRVIDGGDKGVLFKGWELKVFSWFSILLDVQMTDELIEMRDAREFNSFYQKMRKGAGLSLQDNVFLTINGSDDLVELCNKFYDFKICEERGGEVVGRDKYKYKDKDLNIEDYSRDKYNDDIGDYSRNKDKDVSITLRRGNDRDKYKIYSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX30</accession>
    <name>A0A4Q9LX30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative CCR4-NOT negative regulator of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0465p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000465">
        <property type="protein sequence ID" value="TBU13329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LX30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0465p0020"/>
    <dbReference type="OrthoDB" id="2195999at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="4">
        <location>
            <begin position="197"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="3">
        <location>
            <begin position="668"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="2">
        <location>
            <begin position="794"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1726" mass="201036" checksum="B534621AC1532406" modified="2019-07-31" version="1">MDINNDHILKHHFQLISPQKLTKSFVNSIINENTTNTQITSLIFYFISSDLPWDYKEIFSLISQKATHLNWNEIFLFDSTDFNPPDSSCFKHIFDIWNAVTKQPFPYQIFFKKWKNSRAQDFFIIFYLSDPIPITPIITNIPLKYLKNIKIDHPLNSIEIFTLLPFYPHHLITLKKLSPFYTIFGLCLIYPNFFSVLSELFIAFTPENPNLIYIIFNLNPTLCITLTSLLNSNVMSLSRILDLTLEYKMLPYLSETLMPPYFCFDIIILSSRRDHLNLSLWITNTYANRKENFSQTFLMYLYDKFLNEENSKNKIRSEFSYRNGNAVQETDEFFPLNAEVIISIIQTLDILSKSFSRETVLLFSKFKNVLPLEIKSLISKKTTLDQHANEFISSIIKNKKRTDYIALLSKYVKGTPQEKDLALKIFSLLYSNFSSLAKVNSEILCEVYAKLLEKKILTPFYQKKILSVISNALKLKDTQIREYQFALKIFDMIVNCINDFPEFEREVREINGISERIGGEGIAIYEESEDGEMTRIEFYEAIYSSKNRIYFSRNKNNSGIINILCSSDSNCASEYFKYGSQEISISFETDLHTLVTITNNFLKKNPESYIFLVKHILNDHLCKEKITPLTNYLLLVKDPFLTFFIGRSLNVLYYIIDLKPHKSFALSYAQDIGVLIGRLTLSQNKIFPLEIFDCKAFTLYGIKKHRVILVTTFLTCFLSQSINSLVFKPNNPYILMLLQLLSNIYHSFGLSVIRERITHLFNLLNINVLRKTQSFSYYNYLTEYILGEVDSTSRHIISMAIDFSIREISTCILERISGIAEKTSVGIFYLNLEEDVMPDFMHVNTLMLNLVSALTHVTSHEPIKASICANISHFLKLANLEVEMERINEIADKNVELCCKIIEKVGISRILYGGGVRKVDDIKIKKATELLKSREMVVDFDQNDYEFDDFETKPINAHKQTKDISIEPNDLHKQIESINITQQKPTKEKFILFPLNISLLNFPDIPEKMELRPITLSEYNEIKNTLSNIGRRSPDKKSLVVHKEWSNYLATKKEEPLLEFLKKNEDLCEPLCQCIIGQLLKEPHSSKFIDLLQKVMSFSFRTANEVISWLIYADDERKYNSALITEFIKRKILNPLEYDQYMAKIVLNKTEFVLSVLQRLLLSDVKYCTPYDFIFTIEVLAKFNEEKYDDGVYEFLKNVSYLIIESNISTENINLEKISNLEGVFENDLDLNWIYIYIQISWDHFVRYSRIPSSYCYAKIDLLPKTLLEKEWSLAKEGIKIMINWFISSWEKGCYLSYKMFHRFIVILFRYLSISIESRNMVYSILKLFSPENMPFYFIGYLELVNEKITKDLFFNQDGCTFGVEICLSLLKGARIFNNDYVLSIVEQIFYKIFEKCEPFFVENSWLFSYQCPNKFDKLKNLLNSKRSVTTKISGNSAYIKILNALRTENIEKVLEVISEYEDTNDRKWIIYGLVDNLVDNNNISNCAIKVIEKTLNKFKEEIGGVVVCRFMCGNGPESLEPTYKEKSTAKNQIQIIQSYKKRTCRVNGTSSVIKIRGGRPRDEAIMCANNASHPENSRLFKSHSVHEIFDSEIEADVKIRNNIPDIFIYDKRQNRITHLEHGLLANDLSLIYKFRVEIILYVVILNGIPYIYSIVLKKTVKQYPMIEENNLGLRLNSKESCERASLSVIEAAEIHKQPTPSLDQVNNKGYGVKKCESIIFTPYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX77</accession>
    <name>A0A4Q9LX77_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0451p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000451">
        <property type="protein sequence ID" value="TBU13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0451p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="49098" checksum="0AB8914FC3ACBC6C" modified="2019-07-31" version="1">MRNNTNVVGISLPILTTSVNVLYVKEIPRTEPGRGLHSVELRSEHMLLQLLDCLEKTAILKVENKNKTHLALIKGFLKVKYRLAEEVTKKSLEEAQLPKLYNEIENRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIKSHSVQEILDNEYAEIRVDTRIKTDVKILNNRSDIFILDKKKNKITLNEVGITSQNPLQIVETRKLRKYDLLAHELGLIYKCSVDISYVMTWDGIVTKYHKSHLKRLEIPMNQTVETISFDRLRGLESAPNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA0</accession>
    <name>A0A4Q9LXA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0563p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000563">
        <property type="protein sequence ID" value="TBU12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0563p0030"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="31630" checksum="FA858A72097E43B8" modified="2019-07-31" version="1">MFAFLLVKYAKSAKRESKEELTLLFEKDDLLSANNKIFFAYPIQDAYGSSRSKRSENYRRDDSSSRYSTGSSDDSSSTIDRRVRHHSKTKKKIYISRGESKPNPNDAYHLLDDRISRSEKRIVNIQKRSDKSSSKSLKTNVGKSLAHFRKELDCLKREYKDRYLTPDEIRQLENKMDDIENSLFKLEESADKKGGYKYLKKFGDSKENQTHMTNIKSAEPCYTRLDATKLYYAINQHAILSVIYHIGLDDTVSAVLVKNKVDLSAGLKSVYVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF6</accession>
    <name>A0A4Q9LXF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0426p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000426">
        <property type="protein sequence ID" value="TBU13458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0426p0030"/>
    <dbReference type="OrthoDB" id="2191249at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="352" mass="41033" checksum="FB4E913003A253B3" modified="2019-07-31" version="1">MDLEKNENEINFYTENCSSSSLETFIESDVSTLSNLNTDAIITNKNDQSFLIIPQDISFSIYENIKHFSNIFNRDMYLEKKSDSLELEINSAILRRNNSSNCVKNIELYQNNLKSIKILEINSYNLSGEDIKAFDIFLEGNEITVIDDFISIYNNNIISIYKWDSNIKLSKIKVFKTHLLLFYIKSNLLSKNSRIIFYTIILTLIKQKIKRIDSFLEGILLYLDIDNITDMETIDEKIIIKYKNSISYSYDLYLNRIDTPNNYNINSMNTSSTNNTPNINTKNTNNCTKKDILSQINTSNTTIIVKPDIIEINHKEKSFFENIKVPNAQQCVYTSNYMFLLCDKFIRVLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG4</accession>
    <name>A0A4Q9LXG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0541p0020</name>
        <name evidence="1" type="ORF">CWI38_1035p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001035">
        <property type="protein sequence ID" value="TBU11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000541">
        <property type="protein sequence ID" value="TBU13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0541p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1035p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="533" mass="62100" checksum="2402683DC7DAB3C2" modified="2019-07-31" version="1">MILSSSSITNYNIYPSKDKLDNKYNLIFEDKTLIVFFTNINEHNRLLYEWMFLEMDNIATITFLDLKSLNYINIEECINCLLYKENMSLEIMECLNVKNYIRNIDKFRVKKLKKMKLEDIHLTLEDLSSFLEFKNIDNIEFDNCSFDEGEISGEFTFVFSYIQINNMKISNLVVSFLKKAFFGFLYLKNVEFINSFGLLNIFSDTDGGKHANIIELTDLNLNDNFFDLIFYFKNLNIIEMKSVENVSFKIKNKERLELIRLKRISIKDCGLTDEKSNIWFISGLNFLILYRIKNISALFKNINDEKNTESLEVLKIKGTPLCHSDMENISKFSNLINLKLHSCNLDSSHLIYIKKVTFHAEFRKIILTNNKIYEVPGGCRGIFKNFVFAILDRCNFCAGSISLLFEEAKKSCIEVLDFSYNSLNRNDLIFISAFKKLVVLKINGVKLEGDAELDNLTLKGLTKNLKYLEIKQLNISTKDIEALAKFTGLTEIRLSEEPYIFLNETNIKIPCKTFKIEKIINFDLIDSKETDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN5</accession>
    <name>A0A4Q9LXN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0745p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000745">
        <property type="protein sequence ID" value="TBU12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0745p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="455" mass="54499" checksum="218EDC5EE2D8976E" modified="2019-07-31" version="1">MSIHIPYFILFFKTLHFSNLNIEEAYLNNEETNKYFENILENKDKINKGILWMQNFTQNFLIFKDELNEGIIKFYHFSNEDLENKLDPLQKIVWLADLNTFLDKFQKNLDDYYRAMNEFAIIYKNIENLSTYVDNMAINLPCNLFSIKNNFVVQLIQTKNEMFLNLCEILNFLKLYRLEYPLSSKIEEISSYLANVLKSKQRKEMNFSGCARFQLKFKEYLKILKKLEINIQKYTDFIKNSYYSFDFEFLLSQKNHGNLAQDLLNQINTLNNLDSSASYFLTDDIEISKTFPSKYDLDRLNFFINSAIVSFENTFFTITKKITEIQNIYTFLISTFFKCENNLEFKDKLLILNTSEFKNSFLDFLNQNILIYKENYTSSCECLVAIMNDYTFFLNRIIKSTIMISCSLNPILKSYIIKMETSLNHCLKKIQEKRKEFYHFIYTELPQNFFRIYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXS1</accession>
    <name>A0A4Q9LXS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0535p0030</name>
        <name evidence="4" type="ORF">CWI38_0204p0050</name>
        <name evidence="3" type="ORF">CWI38_0723p0030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000535">
        <property type="protein sequence ID" value="TBU02181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000723">
        <property type="protein sequence ID" value="TBU12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000204">
        <property type="protein sequence ID" value="TBU19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0535p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0204p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0723p0030"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="124" mass="14011" checksum="7339B19CFA4EB88C" modified="2019-07-31" version="1">MIFKKNMFVVMTRGRFAGCKATVIKADENSDRVVVAGIAKVPKFSDKEEKVLKKRMNVFVKKINKIHLLATRYKGDTGISNINFDGAFESPASKKTAVMQVTKVFETALINKKVPWLFQKLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY8</accession>
    <name>A0A4Q9LXY8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit alpha of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0364p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000364">
        <property type="protein sequence ID" value="TBU13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0364p0010"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="14130" checksum="59B54D85BF387667" modified="2019-07-31" version="1" fragment="single">MTDISQHNLFIDGKVLVGNSVTEKFNNACTNTSNILRTSFGPLGLDKMCIDPSNNILITNDGATILTNTTNGNDFDIISQFLSNISNQQDKEIGDGTTSVTLLATSLYSKAVNLLSLNVSPRVIINGYRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY92</accession>
    <name>A0A4Q9LY92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0333p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000333">
        <property type="protein sequence ID" value="TBU13816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0333p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="12040" checksum="864432B24AAB8D2A" modified="2019-07-31" version="1">MQKQKFEILTCVIEEREENCAEDFENFLNSNEEDKSEKMKSTDYNTTNKNIWIEDEETNIEPTLEETITAIISLRNHRVPGENKITAEFIKYEGNEPIKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYD5</accession>
    <name>A0A4Q9LYD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0318p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000318">
        <property type="protein sequence ID" value="TBU14954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0318p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="16859" checksum="DBF543198F2C2E10" modified="2019-07-31" version="1">MSTLNLYDCEILKNSRLSLNRFKNLRNLELSASKQEINFYQLFDLAWGQILARIELKNFKIEQRDIIRIFLFKNLVFLKFSNCNFVENIQKCFKRKKGCCLKRLILSFNPEVNYKELSNYLFEEFDNIFSLEIYHPVPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI5</accession>
    <name>A0A4Q9LYI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0303p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000303">
        <property type="protein sequence ID" value="TBU15969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0303p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="457" mass="54546" checksum="CB4913B950E6AAA0" modified="2019-07-31" version="1">MKNITEDKEKDSTDSKIRENSEKENPSLDENNKKTVKLGNIFNLRRDSDSKNNKSSTVKHTNNSSKTKKGISFIFVNSLDNPKNIFNENMPRFKNAHSFNPLEWQKIFTHLKDLLPLLQYNYLFNSITNTDTLYVHCRTFENISFNEIKIKKDTNITKKELQKNWELFDRKYSEINITDYNYPLLSLIPGISMLKEFIYKLLSNKSLEERNIFNIFVGMKMLESILVFSREIIFVLNPNHKIDIFNCDRRVKNILIEHKKIFFAILKILLAKNFCLSKEFFTNLRIIEIGCVCFHKNRQYWANEYHFYFLRALIDSIFLLDEELLNIVHCVFSDYVLNVSCHTGFVSLKRLNFFEIGKFKIAPQMAMKFIRYYLRMLNKKEFIMCRDLNEMIFRDIIGALRNEADIIEKNGSTQENEHMDLLFRCISTFHFIIKFGFNRDIHDHYHLKMLSEYIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ78</accession>
    <name>A0A4Q9LZ78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0236p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000236">
        <property type="protein sequence ID" value="TBU18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0236p0050"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15682" checksum="7B7F40C0CB7118A1" modified="2019-07-31" version="1">MFGNIFSRIKTDVKIQNNRPDIFILDKKKNKITLIEVEITSHDSLQIYDLLANDVEIIPYVMIWDGIVTKYHKSHLKRLDIPMNVEAYIQSIVFRKTFETISFDRRRGLESGLNAEESWKRASMGVIMRAEIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZG8</accession>
    <name>A0A4Q9LZG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0215p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000215">
        <property type="protein sequence ID" value="TBU19285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0215p0030"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="39368" checksum="3D4BE40AC296AE16" modified="2019-07-31" version="1">MNRPGDFSEIFDKNNRFEYCGHIGKGTYGSVCLAFDRFKKNYIAIKRVNFYNSHVLAKRILREIRILKHLRNIQNVNLLIFIQKKDQIYINETRYILFQILQGLAFIHKAGIIHRDLKPNNIFLDCNLNVKIGDFGMARSNFYSDRRDIKSTYVTARWYRAPELLFKYPHYSYKIDMWSVGCILGEILFQKPIFASNTYYDQLKIIFEWNGTPSNDYIRNYASTSMKNLIYRVPLYSKIPFEAKFATIPSQLADLLEKFLEYDPETRIDTADALKHDFITECFLSPEININLYCPVPDHDKTFNEFRDNFRDEASELLCEELIEKSLPLNPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ6</accession>
    <name>A0A4Q9LZJ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0515p0010</name>
        <name evidence="12" type="ORF">CWI38_0508p0040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000515">
        <property type="protein sequence ID" value="TBU02284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000508">
        <property type="protein sequence ID" value="TBU13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0515p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0508p0040"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="118" mass="14031" checksum="503AB55DE9B6AA39" modified="2019-07-31" version="1">MNQEFCKECHNMLYPKEDKTEKKLYMACRNCEHFEDAKSYRVYYDRMTKVKDDAYSTHSKDLVSDPTLPRTNLAPCPKCNRRDACYFQKRDRQQEVALTVCFVCCSCFHSWEGIEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY3</accession>
    <name>A0A4Q9LZY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0277p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000277">
        <property type="protein sequence ID" value="TBU17637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0277p0060"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="24751" checksum="F8A705476AF89C11" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDILPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M043</accession>
    <name>A0A4Q9M043_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0161p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000161">
        <property type="protein sequence ID" value="TBU19970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M043"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0161p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020764022" evidence="2">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="28388" checksum="BBE89DA2CA722409" modified="2019-07-31" version="1">MKCISIFLCIFSRFYCSSDELQYETNVALLIQKFEGLNEAVKKETSTEHEPINRFVSKPINSFSLSYDASVYITEDGNTVQKIGMSSSEGFDMAERLLIPKTDEEPYKDILSISQSNKTHSSSVSEQGISKPCTFPQELCITNDSSSGSISGYKLADETDEEPGDTTPITDDVFVEGEAGFTESTSFCYFSRIPLVSKIDEETGVDEETEVDSETEGGQEYQETEVDSETEGGQEYQETEVDGETEGNEATDGFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M056</accession>
    <name>A0A4Q9M056_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0157p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000157">
        <property type="protein sequence ID" value="TBU19994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M056"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0157p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="804" mass="95150" checksum="A7F995F5AB466ADC" modified="2019-07-31" version="1">MVFLKEKRDFLKKNKQEQTINTLDLLIKYTLLLTSLNLDCISCNNTKYIDFLFSEDSSCSLHSKDMNLYEYYERRMENDSFVLCHGIHLHENNQINCSIPDNEVEHRKLRVIRMNYFDLEKYKFTYIETLIEKSHASVIPIYLNRRIRMENFLVFKNSLVCEDFHPIFFFIKYTEFYEILGLLNHLNGYKYDNIRSIYRKIVEYGLLRPFSREILDDNLNLKSIYLKNTKKSFYILLKVLFDECDFDIEIIKNRFYILEFKTLYCDVIETFEHNSLQLYLKDIFLCRLCKAGSSILKVFFWFLDFYDISSILIYGNENDMKWYMERLGPPYYNQQYLKDLEKLRNQSESESVSFLGNSNYLCLPGYHSGVTNQNIRIDPFNQKMGKIERIILEDLIIMDIYQPIVESFKTILPNVNDLFLCNVEIYFCILSNLIKSDIEYIQFHFCKFIVPYCYDLKNYNYLSPGIPKKISLSTLNILPEVFDVLIHSKNIYCLILQYVNNISECFNKNLGLKSNIYESLVVLKMSEICFSEIESKFISNFSNLQKLTLKYPENGIDSLYLDSLNLCLLSHSLITLKFQGFKNLTLRILEPLKSLQYLYIRNCAIVDFSFSDYSSLKQNLIHLDLSHTKIKDKKNLNLLSNCLNLCELKLSYCGLKECDFFFLKSVNLQKTITEFHLNGNETNSTVLLEFFEYKNIHTLVISLKKTPHSTFSVLKNCKFTTNLKFLFLYDAILNDQDMKTIFSFTELECLTLEDCKIIEESTKVLLFLPQLPSLKTFEIIDLIITDYDKNILLGFYETAILDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M098</accession>
    <name>A0A4Q9M098_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0143p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000143">
        <property type="protein sequence ID" value="TBU20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M098"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0143p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="14763" checksum="DD193F70E769CA9E" modified="2019-07-31" version="1">MGVSYRGVSISSSYRGVNDKGCYRYVIVNNRVLVYVVVNKRVLVYVVVNNRVLVYVVVNNRVLVYVIVNNRVLMIRYCSYRGVSIGSINNRVLVYVVVNSRVSSYRGVNDNIYSYRGVSISSKGVSICSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C9</accession>
    <name>A0A4Q9M0C9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0152p0040</name>
        <name evidence="2" type="ORF">CWI38_0136p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000152">
        <property type="protein sequence ID" value="TBU04322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000136">
        <property type="protein sequence ID" value="TBU20080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0152p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0136p0070"/>
    <dbReference type="OrthoDB" id="2188448at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="498" mass="59357" checksum="64CF31B59E66B724" modified="2019-07-31" version="1">MKDNSTTSINTENTEIVNNDLNEKNTNSLELSSTIIQLLIELNERDYDSSFNQIIEYLETHDSNFVEILIQIIVEVPYNFYLYSLLIIDISSSLKSFGIKFSEKINFYHKKLVKDNDALLLVSFYRTINILEFVGFFKPNQVKKFLNDEEYNQISLFVTGCKSIQHSLKGMDFEENKNFEFDLENDIFYSDELKKELINLQKYKKFMEIFGIENGDFIVSKQIIDKFSTSYKESCFQFYCYFQKEYYDSLILSIINGVVEDKIDLPLYIYIFKKMGMYENFLTNYYDLILKIRNKKTEIIDFYDKIIKFINISMAFIFENFHNLPEKHSSFYAEQVSYRPENDKGLSEMFKSLLNPSIINEMMKISNSNVLIDFLPPKYKNIVFIAEIYENTPQSIELKRIINENDFEKLKEMDKKEFYKAFMVLASPSISHFLTYFEILKNYFVMNSDEQRIFCTVFIEYFNDWNSYKRIVCEKLIEAQFIEETIAKEFLYLSSIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M183</accession>
    <name>A0A4Q9M183_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0213p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000213">
        <property type="protein sequence ID" value="TBU19299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M183"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0213p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="508" mass="60278" checksum="0DC8AF8FD05C2464" modified="2019-07-31" version="1">MILYSLTISDDIKHFDLDKVSFHFSKQVYFSHEMFKKISQEYFKIVNPEIDSYTSFFIKEKENYVSKPYKGLYSEDKIHILVITNVFDLFFSKNIAKNQKSKNLLILFLNTLDINLTFSHSLSKINEFIFYENSIPKPEYKVSEIQDIENLNLIEEIIKNLQHVYQKSSIQDLIFRNKNISETKKDFYIRLFKEDTSNNKVKILEWLNLESKHWEIEGFYNYNGNFNNIALTVKTSNLTLFTYKDTVLDKNIKEIAIHNSKINFSFLADILNINELESLTVSFSDIIMKKDTLIRNQSIKYFYFNCLDITDFPLFYRVISMLTGLKKISFRFIDKIEFVAFEISYVYIKELMIYSNSHTKYFVKLLENQSEYTLLRVNSIVNEEFHSNSLKFLFEKYDLCRLKTLYLSDISIGKTDSGAIGGLLYLEKLNIERIILCDIFFSELFCTSKECNIKILWVLKVNINIADLKFISNLNKLKNLIFVGCNIQQITSMYIKMSFIRKFRIKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M196</accession>
    <name>A0A4Q9M196_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U3 small nucleolar RNA-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0280p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000280">
        <property type="protein sequence ID" value="TBU17622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M196"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M196"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0280p0010"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="88634" checksum="52D535D243B7225B" modified="2019-07-31" version="1">MNEYSHSFSIPCKSDSKGLYYNNNKMYFTSNNSIFILDTSTWEYSHLISLPKQLKNLVINKLIFTSTEDRIYMIGKRGNVIGTLKINSSIFNISPSSKYLAVGNNNVLEIWKIPSEYNFTLFQLERRIVGHYDRITSINYINSDCVLTTSLDCTVRIFDLKKGKSVIIRKFRDPQISAYFDIDTLIFVGSRGKITFLREVTTIKFILDILEGKNIFEEEIVECGSEGNFKNDVIMYGSEIEINKQTDAIKFKKVKREIFKNKFNEPEFVDFTVENYNLRNKENRKVGISETLCIGKDVLDSSYLNGSLYISGKTKEEYFLVQIDDEFLEKKLETEYFEIYKLENFVCLKGTSNLYFTGIKEFKLDFPDICSLDIYRNFIIVGSSDNKVRLYTNFKQLGQLEVNGCFGVHAAEKVIISVSLNGKVDALDYKLFKFRSFDLETKISKSAINEDGSILFLAEYETFNILVVDIKRSKIIETLSVHQGPITCMKFSNNFLFSLSLDNLLVQWNVFQGTYNSLEILGASNFCINNRMIAVSKHNEIQILDLQMNILKSIDFKENIEDISFSIDNSLILVRTNEFLRILHYKTHVCIQSIKLVIQDNIIPILLHYFDKKSFILALNDIKIYEIKSFEINPIELEIDTTFENLQKYLNDKNYFSSLSISLKMNNFELIQNILKTIPQKEVENIVKLLPRNLVIILRKNIKKIVKTDPFICLEWLKNCVVYHKGTCLEGSEVDILRVEIEKYLEDGYRNYYLDEFIKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M197</accession>
    <name>A0A4Q9M197_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0180p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000180">
        <property type="protein sequence ID" value="TBU19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M197"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M197"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0180p0040"/>
    <dbReference type="OrthoDB" id="2189189at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="572" mass="67835" checksum="C041F9627190EA27" modified="2019-07-31" version="1">MNFFRKQIKKETFDSELQLEIISNRLETSQYIEDKLDALKQIYEISLVDPFKVGITCMQKLVSSIPILTSTNLQGDILLKIFKSSNGKEFLDMFMHKEENIKIIGNAFTERKGIFLEILEILIHSDNIKVASIIYKMPDLVFSIVKSLKHSNISFLVPLLKGNEHLRRSIVFEGIFEELIEISETCDDYLLINIFNSLICLLSECHSNQNYFIELKINRILEIWMKRNAMAFDVYMALLDISNSNFKKIQSNFENDYFINLAFIRHRYDFIYRIFYKNISIIKYYLEEKIETLKLFDVYYELENKYQKNYLFDLLVTFFTYKNIKIKIIENDCKYNFYCHVFQNLKEIETTENAIDKDSVDSLILELISEEKLSEFLFDIYKVKESSKLFNLSYFVFINLIREFITPEKPLLAFFIEFLHDCDKSLEEKGICVLFLLEIKINISEIRKNEEYLMSCLLTARKLFCNIERDSCIYFREEIINFIISRINYQLKNIFQYKDCNSLRTDYINTGVSQIKQEDPIKKEQTNPTSPDVSSPKETNRFYTFFSNVSSAFVRNAPKNNDENSNSNVYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F3</accession>
    <name>A0A4Q9M1F3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0166p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000166">
        <property type="protein sequence ID" value="TBU19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0166p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="36559" checksum="A93A38E95E25714D" modified="2019-07-31" version="1">MIKYFWIGSAISSLIVRLLYLIQKYIMVASVKNKDINTEELDNESFLQLQKYNLERLIGYSIHDITITHEILKKKYSSFVSPAKSILKTLTDYAIEALSLSILSFIVIYLIEVLESIGMFKFAIFLIIFAIFYFFRILVRALIEINITKTTKKLDDIELEKKIIDELKSLGFKPDEIYSSPNENFNENITFNLIEPNYRLYENYGYEKHTIGKFVMLISLMTGFKYFYSSDMLQIKLENGTLPTVVIGTFYFLFIDVIISLWVLFVHIKRNMALTFIDSALNKEGKGELFYNSLRVLTTKDGFYLDKLTIWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I6</accession>
    <name>A0A4Q9M1I6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0286p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000286">
        <property type="protein sequence ID" value="TBU17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0286p0040"/>
    <dbReference type="OrthoDB" id="2199478at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17740" checksum="A1DBCC910C122C58" modified="2019-07-31" version="1">MHNKPPHKIVKSVFVYHMKIIFKKYNFYIPIRLLQLLDCLEKSKETSTRRAAILKVENDNKTHLALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVSVNDSSRWLKKGSVRPRNEAVFCYIQDRNVFWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T7</accession>
    <name>A0A4Q9M1T7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0256p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000256">
        <property type="protein sequence ID" value="TBU18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0256p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="299" mass="36084" checksum="E057A27BD0208800" modified="2019-07-31" version="1">MICIYFLFLTVSKANFNKCLTNIKELNTYENDFKKTIYKFLNKEKKIFLESSKYDLHVFSFDLYSVFLTDEILKIIKIQENIEMIFKFALVSNATLFNLEYLDIFYYYTTKKYTKIVVRGQKIKKNFLIMKKNAMQMYLAIFLRQLNFVFKKMTNYNFNVENFLILCPIGHQVYVNNIILNTSHFFETDIYFYFLLIVKRQEDSEEDTVLIQNHQHHTSNIISYEIISLNERYIQSFFEKIKNIVFDINLITLKFSKSVGLKTNSELVYKYRKKYCENELFLSLRMYFSSKCIIKEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W0</accession>
    <name>A0A4Q9M1W0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0037p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000037">
        <property type="protein sequence ID" value="TBU20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0037p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10518" checksum="550C4C7C1EA435F9" modified="2019-07-31" version="1">MNWQNKSNAYLIDVSTSTIDCGLRDIEIHFRQLSYEHYATSFRDRYTNMRGESAYLSVTAAHSRNVLIHERAVKGKDFKLFIKEINESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1W6</accession>
    <name>A0A4Q9M1W6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0196p0010</name>
        <name evidence="4" type="ORF">CWI38_0127p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000196">
        <property type="protein sequence ID" value="TBU04011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1W6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1W6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0196p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0050"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001462">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="198" mass="23142" checksum="96082229143DCBAF" modified="2019-07-31" version="1">MSHSKDPFYRYKILILGESNVGKTSILYRFTEGIFKYTLMNTIGIDFVSKDIKVEDKDVRLQIWDTAGQERFHSITRSYYRNANGILLVFDLTDPRSFDCVDKWYEEIVEEVGNGIPIFLVGNKRDMLDGVDFEDVFTAYSEKAEIKKIKFFITSAKSGDNIDEVFYEMAKCLMNKRSKCINERVTFVKNEYRKRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X7</accession>
    <name>A0A4Q9M1X7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0027p0040</name>
        <name evidence="2" type="ORF">CWI38_0487p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000487">
        <property type="protein sequence ID" value="TBU13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0487p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="26936" checksum="62E44E0307DFDB17" modified="2019-07-31" version="1">MQLFHNKKFRIAIIISVVLITIGVVIGFIGYNSACKIVKDFREDFKTVSKSDGFKNMLSLFKTSKIVVFLAKDKPFVGVLGFKFRNQTLYDKMVQLLEQKSDDLILFKGPEANLYFADKSENRGLSKILEDISFLAKIGFWLKSAPDVKFIYEISDFLKKTFNKTRENETKRVYFNILDEKKVQAYEVSYSVPRAPVFDCIKSFEFVSNKNITCDSFECITFIVHKLIRRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y9</accession>
    <name>A0A4Q9M1Y9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0252p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000252">
        <property type="protein sequence ID" value="TBU18148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1Y9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0252p0010"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="23471" checksum="60D541C8BDB73B2C" modified="2019-07-31" version="1" fragment="single">FQEKIETTQILIEDLKKNLSNFIFEAKNEQEELNTENIKEMIRNRLYKNAILLSKYLNRIEEQKKNEKLRRNRFSAEQENRNVTETSEANNQLQTELLIEENEIQNLRERVRENIALQINELGQVVSDISLHVSMQGENLKRIDDLMGDSRGFVQKSTHEINKTWNMIRNRRNTFIKFFGFWIFLAFVFWILKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M263</accession>
    <name>A0A4Q9M263_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0206p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000206">
        <property type="protein sequence ID" value="TBU19515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M263"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0206p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="37086" checksum="3428EE9A202A9CF8" modified="2019-07-31" version="1">MEIKNMRTKTIMENHGICVDHNNLYAFSYKYKRLAICKENMVSIYDLNGELVDIISEKVNKKIFKILFVSDVLVIFCRFSCSICSLNDQGIIKKKFKKRNIGFTHKDNILVIISDDLTCKELIFNEDRSIIESSIDFLKVTKEFMYLEPIKVEDNHDFDIKVKNQNKSILPFFKRINISNRCGLSNPVHSLHNRLLYHYASLVKSRPTRTYSRYISQIFHTRKIKKSIYRYGSKRIVKDNNRLYIFNEEKLAHKISLPIKSYASIQDTIILTTEKCLYTIISNKKRCYNLLNGILVKDELAILLITKDTILEISNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M269</accession>
    <name>A0A4Q9M269_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0023p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M269"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0090"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="75750" checksum="246C4A0CDAC9073C" modified="2019-07-31" version="1">MYLKAWLKSKSSSFLFYFFTILFRDISFELDGINSKYCIRASALKHKTSNSNANTTEKNDFSNDDQNDFIKKLHSQIFEIWDKIEKQPRKMKDLDVFFAEKSSCISPETSSLFLSSYVIKENSLHGSASTPFEITGLNDLYSSVDSCIDNILNFKNFASTYDNLMLALKKYENTNFLLSGENNIAIELRIKIEKIIQNLHPYHKILLPEFESIRDILLRFLSVKKQLQDKYPTIYLLVSLLDKILSQINDDKSNFKTYLYIYNIDINMETNNKRLILYLRLVMVSLLKNIDIDTYKLLEYSALILLESFIYSPDNIQSKHKLFYLNVFIKMYLRIFHLSNYNRIEIYEKINRFLDKFFADEFIRDYDANNFVEWNIISIFSKIFPKLNIASHLNIYIEDIKSKIIKEVETRRTDLNSFDSYKLRVELAHLFRRFIPNFNYENINSKQVIEYPEFPNILQSNLSFYITQNIYICYLNNILVYIFLDDSNLDFIHFSDLYTNVLHDLYLKNHIPRLSSVVETEKLRKYDLLANELGLIYKCSVEIILYVTTWVSIITIYHKTYAKRLQIPMNLESYIQSQYLRRQGLESGLNAEGSRKRSSLSIIMRAEMHDKEEDGVKTENNENNTLLISEEGTTLEEPTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H8</accession>
    <name>A0A4Q9M2H8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0206p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000206">
        <property type="protein sequence ID" value="TBU19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2H8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0206p0010"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="308"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="499"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="609" mass="68795" checksum="E5575C64FACE9A2D" modified="2019-07-31" version="1">MKYIVVIGGSLSNIGKGLVSSSTGVLLKSKEYDVSFIKIDPYINIDAGRLSPSDHGEVYVLEDGSEVDMDFGNYERFLNIGLSNLNSITTGKIYDEVIKRVKSGFYMAKTVQITPHVTDYIEERIQKVSRLEVKEEDGSYIPDICIIELGGTPSDIESIIFVEALRRLKNKVGPSNFMIISVEFLPKMQNGDQKTKIAQSSVKKAASLGIKPDVIITRCENSMSQSTKQKISDFCEISINDVYDLPITVDAYDVPNVLNIQNYFDSFVKHLNLENKNSSSLLYFPNLNRINEKSLDIAIVGKYTSNSDCYLSVVNALRISCAKYNHHVNIVWIESTDLEEIADCNSLFNNIDAMLIPGGFGTRGIEGKITAAKYARENNIPFLGICLGFQVAVIEFCRNVLKISDANSEEFDALGKNKVIIRMRNKINQNIEITDSNKENQISTFQTDNKFKVQKNNVGLSYSKNTDLNQEKICLGKTLDLKTTDSYILTDEVIEEISGMKIRSGTHDINLKKESKAFEIYFSSVISERHRHRYEVNSAYASKLQKAGLLFVGHSVRDNRIEMLELSDHPFFIGVQYHPEFNARPEKSHPLFNAFIEEAIKRKYNDQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J9</accession>
    <name>A0A4Q9M2J9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C19 ubiquitin carboxyl-terminal hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0202p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000202">
        <property type="protein sequence ID" value="TBU19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0202p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="26434" checksum="527D7923810AA520" modified="2019-07-31" version="1">MKKNKEVDTAEKLLKIRNNSGTKEFSNLKQQQDIQALHTALVSACLPKNLNFNIIKNPISYVDAANLFRVIPVFYFLTEKRIIHQLKKQTETVFELNNCFILPGTRNIEQKSREYFLPEIVKNTEEDDNKVKSKSCYSNKFNERLKICKELIIDENYKYELISFGYHRDNLLSGHYVAVIKPDENIWAVITDDDVKYFNWCNILNYLDYYEYKPVLFFFQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T6</accession>
    <name>A0A4Q9M2T6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit 3 of CCR4-NOT transcription complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0002p0090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2T6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0090"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="118"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU21025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="231" mass="27745" checksum="F3FBB2D66CD883E8" modified="2019-07-31" version="1">MKKNTTEQKKENHPSKNSPHKLDQKKAIEPPKQEKRTPAEVWQNAARLLETKKKEPPKKVLLTFEYPEIQKKLSQLKAKKEENSTVKTGNSHSFTSAEIENAIIYRTFFHITDKTNTDTPQHQNTSHTSSNTNLFHDPLFYTKLDIDTLFFIFYCQPNTVHQYFAAKQLKNYSWRFHTKYHTWFQRLEEPKIITESYEQGIFLFFDYDVTWTNRKKKDFTFEYKYLENIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M343</accession>
    <name>A0A4Q9M343_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0128p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M343"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="49158" checksum="8FB22358BDE628E3" modified="2019-07-31" version="1" fragment="single">EDKITIYSVGLRCKYLDLGEHLLKLGVKDFFSQEILIRVVSSVILKPVFLKFLTDFFFILVKNISDKKIELNYLQIINPNYTIENIYLVNIKIDCTNFEEYFTEYFENKFSQNLINNLLTNDSVHSIFENNTFDEFFYKNILNNIILEQIENKFMYCLNPNEEYIFCVKAKFFQCVKINETLEKNLSFLFKDIQPETYEYKNSCTGLLEHQIDLQKFIDLKNIFLKNYFNFINIPKFFLDFFPLFIDREIPICINFNENIYVENFKECFYKFFLAIDTDKMKNSKFLFHESIMEYEKLKSFFMEKQEEACAFYMIFSNELYKNRKSEIFFAFFNFLPFKNMKVQISYTKNILLSCENTPFIVSKNSFTIKKYEIIPLVSGNIPISDLFIIYFEDKQLSKHKKYLLIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M385</accession>
    <name>A0A4Q9M385_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0145p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000145">
        <property type="protein sequence ID" value="TBU20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M385"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0145p0040"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="100124" checksum="9EB0BFE7076EF1A9" modified="2019-07-31" version="1">MNNKRFKKLQHNTFNQIRKEKSVKFSIKRLLLTSIRRNIMFISFIILFLEIHQCFRITIDFTDRALSEGVPAKQITSCLYSTQHCRKRKYKTDRVVHQQNKSLISSSKDCSYEYIGQKEYNKAEKILRLDEKYELISNVDYKSTELSCNKDSYKKDPRCLPNSNINREAKVIKYSEDEKVIFDPNISNSITFDYSSDFIIRSKFFDDLGKTGLEEIDLNINNITKSNVDIVTCEMLINILICGEDFGFPDLIDENFLALICLIFDLSCYSKSGELERLYKNLLPSFFVYLGNKPRSKVFQIEIVEEVEQKNVFLPFLSVVYDSVDISFDENTKELEFVKKKHYKKSKLLEINITDKLIIRITPFALIHMQENDTKEKEIFLRYLFSYYKINGIRISADNKYYSEYKNSKYNCDFSIEESIISYQKINICYLRRLFETKRKNEIKYVELERIILSIDDIIYLKSLKNIETLILVNCNSEIRDSFVQYIPLNFQNLINLTIIGYTFKDRFWEYFNILNLEILDLSWCKHLEKVKQIFHKEMNNLKEFRMNNASLNHRIINYILRSPSLEILSLKGLNFSRLRYYERFIVMKQKYRVLDLSGCRFNKLFLEFFSTNIIAEILFLEHLNDSNNLIQILSQNTLHLSTKFLSISENFMSLNLLEIIHKFKSLECLRLIGMKMDSLRASYSDIILESNLFELDISRNKLENIFFTFLYQFYSLNKLDLSNCNINAGFVKYLCVPNISASLKNLDLSGNNLGASDIYNLRFLRNLNHLIVSFDNDVFSEFTKKYGDFMCLNLVKLVLFSTKVNNEIINCIMAALPSIKYVELSECNFDDVVFKILIGYEIDVLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3B9</accession>
    <name>A0A4Q9M3B9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5095 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0137p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000137">
        <property type="protein sequence ID" value="TBU20071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3B9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0137p0030"/>
    <dbReference type="OrthoDB" id="2190512at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031515">
        <property type="entry name" value="DUF5095"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17016">
        <property type="entry name" value="DUF5095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="31258" checksum="70CAC8BDB817475C" modified="2019-07-31" version="1">MDKKYETEDKENIIEHNKIPTGNPFSLFKNYINESKVAFAPITKNTTIKIDDEQFFEILKKKNIESKPNIKEEVHKPILDNFNIIIEEKMDIKMIKYYKFPFSDQIKVSDTQLFAQLYAEWKIAFKNVFSNYRKYSNSFVMKFDSEFLIFDTFLQATLGMKKYFIKNDIKFEQIQNRLKILSPTDILLVYDFIINIEVNQLDNLPFIISKHEYYNSTVYETTITTLKPIKKAENIFFTYKINGYFLYEDFKEYINKQIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3L2</accession>
    <name>A0A4Q9M3L2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scd6-like Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0022p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3L2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3L2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0070"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lsm14-like N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14263" checksum="FE992558FAE7FA0A" modified="2019-07-31" version="1">MIIKKNTCVEIISASNIRYVGTLNESDDKMITLLNVKNFGTEDREARIKVPSSNKIYDYMIFKKENVQQMTPVNKYLYGFYDNSSQEIKKTSNLKNEDSTHNNKDNNDLINSQKTFYDNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3M2</accession>
    <name>A0A4Q9M3M2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0116p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000116">
        <property type="protein sequence ID" value="TBU20191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3M2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0116p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="10013" checksum="79A7E0FE0457882D" modified="2019-07-31" version="1">MTFYATEKTNTSLPLHPSIKCHRGTDYGQGAVIYVMHIIAPWQTLLSTSYNTFVNNLAHSVEFAQSFIKSWDISLVKDTDRMTEEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5H5</accession>
    <name>A0A4Q9M5H5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0002p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5H5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0060"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14668" checksum="ED2AEA6E9A78C68F" modified="2019-07-31" version="1">MVKEMMLGVCSYCNQSRKTVEHVATRYVKILGHDYTKLHNEAQLRKYELFSDEMDLIVKVMARSSLSVIEISEAHKQPSTFLKQVNIQGLCVKQLNMKNILPLTILYGITTAEKPTINIMKFRFSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX30</accession>
    <name>A0A4V2JX30_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1999p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001999">
        <property type="protein sequence ID" value="TBU10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1999p0020"/>
    <dbReference type="OrthoDB" id="2195934at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="8">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="23414" checksum="87E7C7028D50A9B9" modified="2019-07-31" version="1">MEDFTIDNLLVQKKFKNEKDLKEYALNIRRSIQDYEIFLYENDKYSNQEEEKIKEMRKRLSEYITVTTKNIKNTPKEEIKEEHKEIFETVKLVARQVTKADVNTQLLEKSTLKLKGLNYSNKEIEREIQNTRNNILRSKKEERKEIICLIIGFLVFIGVCFYIILDRLHVAKFIVFLIRNCLFRLNNVPNRSDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX47</accession>
    <name>A0A4V2JX47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1820p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001820">
        <property type="protein sequence ID" value="TBU10362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX47"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1820p0010"/>
    <dbReference type="OrthoDB" id="3562449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="59"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="27642" checksum="997485E1980F79B4" modified="2019-07-31" version="1">MSRTIISDVDSIASDSEDDEIGGDTSSDDSIIITHRRKRLRIEKIPPEAKKAIVGEAKYMAHENSKPNPVILISSNSDTNSVTIKKKKGNFKNEKMKPSMIHDYNKYMGGVDECDKMLYVYLDERRTLKYWKKVVFNVFGRMVLNSYILYVSNTTEKKMNRLKFTSKIIDDIEKECMYHKNSVSTQPSSSTNKFALEKLPGRNLRQCAVCSNRRSGIKRSHLICACCKKGLHAICAAKHSCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX78</accession>
    <name>A0A4V2JX78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M24 metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1563p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001563">
        <property type="protein sequence ID" value="TBU10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX78"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1563p0010"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="313"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="382" mass="44057" checksum="38262E674AD04CD0" modified="2019-07-31" version="1" fragment="single">MFTLMVIYKLLISKNYDGYIINLADEHINEYVSPSDNLIEYVTHFTGSNGMALILKNGSSVLYTDSRYFIQAEKELSNDFKLKKMGIDENIYEYVQTIGGIKKIAINYKNISYSRLNDMRSKFEKNGVEIVHDDLTESIWPNKPERTYNEIIDLEKIKSNTFLDVNSNENITGSNYMDKINKLREKLSDDQVFILSELDSISWLFNLRGSDIDYNPVFYAYSIISNDKAIIFIDREIERKDVEIKKYSEFYDFLKGVEATRVFVNSRCNAFIVTELGEKKVEVSDLIGELKSQKNEIELKGFELAHINDGISLCSLFEWMENNIGKTEKEIADKLEEYKRMLPGFISPSFDTISAYGPNAAIVHHRASETVVESKNLFLIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX81</accession>
    <name>A0A4V2JX81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1581p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001581">
        <property type="protein sequence ID" value="TBU10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX81"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1581p0030"/>
    <dbReference type="OrthoDB" id="2400393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="311" mass="36137" checksum="5CF1C2CCE1FFBED8" modified="2019-07-31" version="1" fragment="single">LRARTQKVRDYLDFLDERFKEHCVPSREISVDESVVEFKGKISLLTYNPNKATKWEISMYVMADANTGYVYSILPYYGSLTSEDLIRPDLPVSTRIVLELCNKLLDSNPGSTGYHIFTDRFYTSLPLAQELLKLNIHFTGTIQSNRKFQPNSTKKPRFSENNTFACRSGNILFSAWKDKRIILALSSWDVSGTEPGNLIHIPHIIVNYNKYMGGVDRASSYATFYCFLRKSLKWWRKLFFWGLEASSVNACLRYKIVQIRQNNRPINHLKFVREIVPSTTDKEERLNRKLHIMRMEPVTFAAYALANQDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK5</accession>
    <name>A0A4V2JXK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0877p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000877">
        <property type="protein sequence ID" value="TBU12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0877p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="493" mass="58052" checksum="EAD02411DCC765CA" modified="2019-07-31" version="1">MNFEGYLFQSIVIKNNDLSYIQMPKRAEKERIKTSFKTLRNKEDGVKSLKTKNNTSQISESDLKEERMVSCTTAEYTLPNLSLIDSGEESETILRSKNVDYFDKHIFSSINNREILEIYNILYEPFYDFVNQDNYVKHFEESYKNLLLTSKKTLENIFIKDKKYNLNGEEILKKIHSLVKIDAYINDIETEVSADSFFTIKKPNEISLQYIIFGEFSLYHFTGLYSKLLDKFGNTNELMNFLCNKTAKDVMIWSKELNQTITGLEKTEILKIFSCNSIKSNDFYLSYKNLRKNYDDLVRYDKEKSNIFYINTKKSEVSQNLKNYLLFPNMLLPQIISKDQVQKKIFFDVDLLFLAYINLFFSKICSDGKILYENFCCLENDQTLNNIIPSCWSMFEKSQIFLDFIYLSKQLCSNSNDNASFLIIFDDISNNLVQKLLSKYFKYEIFIFSGHNVSAEFVILMSKANIGFIFQIFLENVKEELLYSIFKDSEPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM5</accession>
    <name>A0A4V2JXM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0787p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000787">
        <property type="protein sequence ID" value="TBU12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0787p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="798" mass="95473" checksum="10FF1EBE5D971184" modified="2019-07-31" version="1">MLQDLYVKDIEKQFAIKKCHYSFFIILNVFCSVYVTNVEFIVINDENNTTGLSISDLPMKMTDSEIYFEELINEEYKIIVYKNNILRFESYNQKPRYYNPNIMGIPYRNNMLLSSRILKQLFESKKANIKIIFRDISYSSLLLFLKLIDNPDIVVNQIKVREFLDILTIITVLDIKKTKERNDFLKELLRNMIFTMKDANSIFDIEKYYKNYHYKHIKNSILMDMLIFFIEQITFNDKSAQRIIVLSDMFHLNINFTKVFFSHDSPHRQKFEDKVCLRLDTLNITKLHRMIHIEHLRKTWRFILQITRLELLYLILLSEDICEKAIRLFESVTLHTKKLYILCFKNPIKLFMGKKAALFSPKLKEFKLKYDFKTEELKDILNFFSGLQRITLVAKTIDFEKLKLLVEFSMKNKTTICKIFCSIYESLNTEIALLRLIPSNLLFYIDYFEHESDSKQIPIHYMPFFYYYSYRYMHTRGTGLPNNIIFFDCSNFKNIILNFKHNSSLFELDNSAIISLRYFKAVKYFSLYNVLINKELFLYILESNTIIFFVITNFVCEYNFDLLKNSDTVNRKLETLLLKNSPSYIDSRILDFLDKFKCVTGLKLINFKTNYNKAYLKEVYEFFFRTKKRNENKICLKCLEIINILEKDKLSNILNIISETYELSRLSKITFEVYRISEAEYHFLNEMKELKVISIRLLDRVESLNFEKLFINYGSLDTIVSLIINIGRIRKKDIEFFKRLKNPAFLSISCDIIDYETIKGFKRNDFRTTILEFAKPARAERSVEINNYLDSEFQLNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR3</accession>
    <name>A0A4V2JXR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0339p0040</name>
        <name evidence="2" type="ORF">CWI38_0608p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000339">
        <property type="protein sequence ID" value="TBU03191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000608">
        <property type="protein sequence ID" value="TBU12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0339p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0608p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="77" mass="9309" checksum="8EF3BCC7A556EF61" modified="2019-07-31" version="1">MKKENKYNLLRKYLTIERQFTHKNIEFEILKGIKTPLFIKENDILCPVNENNTEDLYNERVKLKEKIKKIKNTIKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY17</accession>
    <name>A0A4V2JY17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aberrant zinc-finger domain-containing microsporidia-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0288p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000288">
        <property type="protein sequence ID" value="TBU17098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0288p0040"/>
    <dbReference type="OrthoDB" id="2188337at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031514">
        <property type="entry name" value="Zf-C2H2_aberr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17017">
        <property type="entry name" value="zf-C2H2_aberr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="805" mass="93365" checksum="1A23130BB5422F4C" modified="2019-07-31" version="1">MDIKGQKKQQFKTKKKAPLQTDLFYKCFFNDCILKYSTVHGLKKHLKSYNHLSYLANINKTIKCPFRDCNATGEITSHAEKYHSAFFEVIKEYLQYLSKINISYIRKENTSNITTTKKNVSFHDICKVDLIINEIFSSVFCKGILKINDSENTKSTFYCSIPGCGKIFQSHIAYKYHTKTQVHFLSYIIAHYERKKDICLDHNHLIGIFKKYFKIVDKFYLTDISHYCSNKPDLIVPILFTTENTILPTNKSKNSGFAFSTVKRPSFFQEKIPEVSDVDSGQTDNILNFKSDELDSFIQRKNNINFLQDNQVFYFNGKRYNSIDIQIIDNLRIKNTEKKIICAEKTTFRNKKIIFVSLTDFSTKNFQIFKFSSGISFIQIMDISLATFYTLKFEYGYVCKIHICSSDSLQLICLFKDGKIRSFFLEGNLSNPTVLNLKEYPGKNYTNIAFHNSNTSHAKLLFATDGFKLYTFHDSTLLHTSQVFSYPITLIHFNLDKLICTDTNGTIYTSNVDYTQTKPLFSQFGTTYVAPHIPNHLLISDTFSNITKILDMTRPINKIRIISYNSTSESITDNTVLYIGTYTGSVILPQFTTKKNICSYNIITCHSFENTLFFFTNSHTDMYNFSIKKQIPPRDICTPKNTNILYTSHNQNDIKYLDNTNRYDSKYTKDNTDIKKNIKDTRNIDRLDNTNIERNIKATNNKYKSDIVYNAYTNNNTNSSIHRKNSIGLDCIDNLDISSNNQSDLNLNSKNEFDFTVDINKNTKDDKELQISDYSNSVISLHITSKYLIIFYSNGYIICMEKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY54</accession>
    <name>A0A4V2JY54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0193p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000193">
        <property type="protein sequence ID" value="TBU19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0193p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10895" checksum="A58A14ED725AFDA0" modified="2019-07-31" version="1" fragment="single">MIFECEIVSIPENYRPLLPSNRSINTDEESDTNFGTKDIIRLFLFVFLLLSSYVINSVEIITLREKHSKKILFCILVFVILKLIYCFISFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY89</accession>
    <name>A0A4V2JY89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0111p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="94243" checksum="74E4CE96A38A49AD" modified="2019-07-31" version="1">MFADLDYSKTHNNTLFLLIYLSCYVQLTTVSFFVLNDENLINNLNAIDLALEIKEIENEPIGWSIEEDKITIFKNNILIYESCNNGTKYYNPFILTIPYINGMLLNSNFLKTSFDSKQTNINIFLKDISFSALLLFLKLIDNPDIIVNQMKTRDFLDILMIISILDTEKSKERNYFLKELLRNFMFTMQNGNQIFDLERYSESYHYKYIKKSILMDLLIFFIDFITFNDKSAERCIVLTGNKYLKFTSHEVFFVFCKGFRKCANFEIYLRLNDIGIYQLYKMINEKYLLNMWRFLLNITNIDLLYLIFLGIDTYIKATKLFSFVIFHTEKLYIHYHAHPMELFCKRQLSLFSKNLKVLKLEFDFTLDELKIILNFCDNIHEIVLNTRVSNFEFLDLLITFLVKNPDKICKLYSHIYELDNTDISVLRNFPKNLIFYFLNLTNQSENIEIPLQYLPFLNKYRYSNYENLKLATNYILLECIRYKSIELDYKEYSSPFEIDSAILKSLGCLNTIKYFTLRNILVSDELLLFVLNSKTIECLVIQKFILKNNFKYYLRNNKINQKLLFLDLIESLYDIDQNILVYLIQFKCISCIKLINIYFTKSYFQKFYQYLFRFVTKKDNRICLKFLKIFTNSNNRKIFDYLHFLSEIYDYSMLLKIMYHVYTITNLEYYFFSKMVNLEAISIEIRHLSDCINFNIIFINCNLFKTITTLAIYCSKINKEEMKFFKSFKNLMILCLSCEILDYEAISCMRKKDFKTAQFDIIKPIRADRSNEINNYLDSEFENNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM9</accession>
    <name>A0A4V6MVM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CorA-like metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0567p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000567">
        <property type="protein sequence ID" value="TBU12982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM9"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0567p0040"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="749" mass="87806" checksum="5AF04BBB92DB10A3" modified="2019-07-31" version="1">MECTNTIMEIITIYRKMKKGRENQNIYRMLLNIEAGLEEVVEMKNISEEKRISMSIEDGNVGGHLDGNEVVNNVDHTEDKRISMSMEDGNVEGNNLSHTEDKRTSVYDFSRYRNLGESKYILFSKSTSLIQSDCLFDRFEELNLTVLKHYWLNIFNPSEHDLQILGLYFNINDITLMDIRERNTEEKIEIFKNYSFISLRLLSEGNLYSNEDIDFNILLFKDFVITTHDKKWGGISDITNFLSLICCHTVMVPDWVFFSIIVEFLQDIKHIIDTIGPEVVDIQTLSSNLNLEIENLLRRNFEVVNKIYSLRKFIKPKMLILSSISTRYNKRVDKKVSPHILHCLKDFNRQEKQAKEYNIVLERCQDLFLALVNMEQSKQGNDMNKVMKRFTQVTFIFLPCQAVASLWGMNVPVPWQKEKGTFYFYILMFFGIVAGFFLYFFMTKVKFKGKKENILKKHKNLCERVNYMDKRSINIFKEVLKDIDTTHLAPIKGFLKVKNLEEAQLVKLYNEIEKRKLDSKLYNAKKNELVTVVCYIQDRNVFWGADDVCQYCNKFGKTVDHLAIRREKMLGHDYTRRHNEVVRCLHLLLLNKCKFKASKRIIRHSVQEILDNEYAEIKVDTGIKTDVIIRNNRPDIFILDKKKNKITLIEVGITSQDLLQIVETEKLRKYDLLANELGLFYKTSMGVIMRVGMHEKPTPTLKQAIREEDGAKNLKTKNNRTLISKNGNVLENCSGKRGRRNRINIVKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVU3</accession>
    <name>A0A4Q9KVU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1512p0010</name>
        <name evidence="2" type="ORF">CWI38_0507p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001512">
        <property type="protein sequence ID" value="TBT98988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000507">
        <property type="protein sequence ID" value="TBU13187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1512p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0507p0010"/>
    <dbReference type="OrthoDB" id="2188008at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="491" mass="58889" checksum="226E563A97655B0F" modified="2019-07-31" version="1">MFNGKSKEQSLYSTVNLIKNIFKNLKRNTPLMHVCEICNTEFVCYDGVYVCQSGHTQALTQEVNEEVLAISRNAFSSKHIKETNDYVLEGKPPIYKKLLAFIISYKELKKCLQFESDTYLKIYLKMCNFDPAMSRKCTLTFRFSYLVDVLYYSKRVHEEKKGKTFFYSSFRKFIDKIPFQIFLEQIEKEYRISLKDDTYVLITGRDVRSAKNCHIFVKYLGNARYPYKYMYDHKVDKFLLKPKEEIERIKKRNKIIKSIIRRNKRRKNKIPLNEKLKILSIPKRKLDSDLRHREIFRKGIRRDFEMQNTYFNEISRIFGIEVTEDLNIQYHKFYSMLDHRYIVFIPEFEICGFLYVYLSHKKIPFNEKAAIENLKKRGLLNDLNPESYLNSLKIKGYFASDKSLVEFAEKPVEKEIKDCELDDEDIYENLKTLMCSFLFLSKRIFDHFCSKVITLINNSYSRAANRRFWRSYYRSSLVKRSYDMFVHSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KX53</accession>
    <name>A0A4Q9KX53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0692p0030</name>
        <name evidence="5" type="ORF">CWI37_1624p0010</name>
        <name evidence="7" type="ORF">CWI38_0007p0080</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001624">
        <property type="protein sequence ID" value="TBT98729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000692">
        <property type="protein sequence ID" value="TBU01517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KX53"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KX53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0692p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1624p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0080"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT98729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU01517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="183" mass="21446" checksum="D3A302DBCE97193B" modified="2019-07-31" version="1">MEDENVYSVEKIMDTRKFKGKKQYLIKWDGYSDEHNTWEYAKDIFCKDLIDEFESRCEKELEAKKVLQTQITSSPIKEKARPRRSASSSISEASKMDENVVNKKKKSSKDEGITTRIITNKWDDKVKRIACVHRNLSTSELEVEIEFTDDSVSIVPIEHAHLHCPLWLLKYYEDNICFSEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1L3</accession>
    <name>A0A4Q9L1L3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0758p0020</name>
        <name evidence="10" type="ORF">CWI38_1055p0030</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000758">
        <property type="protein sequence ID" value="TBU01264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001055">
        <property type="protein sequence ID" value="TBU11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1L3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1L3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0758p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1055p0030"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU01264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="333" mass="36655" checksum="F3AFFAA109981FF0" modified="2019-07-31" version="1">MTSETKKETKITKEGKLTTFTVHSRPITDLAFNEDGDLLFSTSLDGLLCAWRTNGIFLGSYDGHEGTIWCLSVDPFSTHLMSGGADNAAILWELETGKQISKITTNSMVRGLNFFRDGQKCLITTDTSYSQRSLIGIFDIRSNALSFKINPDVSVTKGIVDFSENLVAFSDSTGEISLLDIRNEKIIKSVKVHTSRINNLRLSFCRTFFSTASSDAQAKIVDFENISVMKTFTAEEPLNSSVIFRTNDKLIAAGGIAARDVTQTKGKDSFDVNFYDIPTAKMVGTYSLHFGTINCVDVHPSNNYFCSGGEDGIISFLEFGSEFSKAAFSKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAF9</accession>
    <name>A0A4Q9LAF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0134p0030</name>
        <name evidence="1" type="ORF">CWI37_0197p0030</name>
        <name evidence="3" type="ORF">CWI38_0656p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000197">
        <property type="protein sequence ID" value="TBU04006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000134">
        <property type="protein sequence ID" value="TBU04446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000656">
        <property type="protein sequence ID" value="TBU12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0134p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0197p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0656p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="188" mass="22885" checksum="5F1FA77F01611BA3" modified="2019-07-31" version="1">MTKICYINLIFINRLFFINGSNDSKSFKSDDYRAYEYAYNTGMERYVKLPEIHISIPKNTPEKYTFIEQKNIKRLILPKIYNDTKIKENILLYHSVEENIYKLMEKYKYLRDNIQNTTANFFTTHSKYYNRSWELLYRIRRRIKLIVKFHKGTNENYNLKQLEICNAMIDSCYINMNILEQTFLKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBZ2</accession>
    <name>A0A4Q9LBZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0023p0010</name>
        <name evidence="5" type="ORF">CWI38_0896p0010</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000023">
        <property type="protein sequence ID" value="TBU05328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000896">
        <property type="protein sequence ID" value="TBU12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBZ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0023p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0896p0010"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="210" mass="24603" checksum="5E6024487ED09960" modified="2019-07-31" version="1">MKIIAITGGIATGKTSVANILMDKGYVVINADKISNKILYKNLEKVYQIFGDSVKNDDNTLNKVELRKMVFNNKEKRKELEKLIHPKVYAEIIFRLLYYAFMGKSIIFMEIPLFFECKLNKYFDSIVVYCDYETQRNRLIERDGNLLIDQKIKSQMDIKYKICNATYTIDNSNSIESTKIQLDKINFKGVNIYFYIIYIVVLLMVYSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD40</accession>
    <name>A0A4Q9LD40_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0100p0040</name>
        <name evidence="3" type="ORF">CWI38_1174p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000100">
        <property type="protein sequence ID" value="TBU04690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001174">
        <property type="protein sequence ID" value="TBU11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD40"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0100p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1174p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036357708" evidence="1">
        <location>
            <begin position="26"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="438" mass="53292" checksum="09718330A2516D96" modified="2019-07-31" version="1">MLHIKNHSNVIMWFVLVFSINLTEFSSKLDNLCEKRYKYSENILQTFADTDYFEILLETLNLEMDVNESISNYIRRSESQMFKIFIDTRNNEELNTNILDKIECFYLKKCSLEVYIFSVNYFKFIDDGNTTYIRKIFLYDKLLSVLIAKLFIFSKIFRIFSVCFSDFNYTYFRFMIYDVKFSSEYVLNLPDKFLEFVTDTYAFSITASIFYTRIILSSKCYKNLNNLDNKTFYEEQIDYFNGIILKYQIEFYWRYEYALNHDQNSYSFKIRKNYSLKIVSLEISKSLKNDKINIKTYISIQDRFFSYENIFFYDLAKTRYKTLILSNDYRDNSEYIYFEYYFIGYDFRTKTAKYIFKSIFFEKKDKIILYVDENLKIVNILQYKDINNAYATINLENECIENIIANLFKWLIVKLFLPNLNFTQQIFINMLYENIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFB4</accession>
    <name>A0A4Q9LFB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2597p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002597">
        <property type="protein sequence ID" value="TBU06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2597p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="19206" checksum="38DF4C35C422DCDE" modified="2019-07-31" version="1" fragment="single">TTPGQPITTPGQPITTPDQPITTPDQPITTPDQPITTPAQPITTPDQPITTPGQPITTPDQPITTPAQPISTPVTTPAQPITTPVTTPAQPITTPITTPGQPINTPKQPAQPINIPKQPGQPIAEKQKKLSKPEKAEESSEKVKKKGEWDIGKVVLIIILSVSSLVAVSGLGYWIYITHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH02</accession>
    <name>A0A4Q9LH02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2517p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002517">
        <property type="protein sequence ID" value="TBU06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2517p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="6766" checksum="63DAFCD7768ACDF3" modified="2019-07-31" version="1" fragment="single">EESWEGASKGVIMRSENQEEPTTPLKEAGHDEDDEPTIHINEESDLEEETVVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJW0</accession>
    <name>A0A4Q9LJW0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-like endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2347p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002347">
        <property type="protein sequence ID" value="TBU07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2347p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24207" checksum="F677C49234169E89" modified="2019-07-31" version="1">MVFINDREGIIDKTLEGYSMFAIASMYRINYQMVTSIALKLTLEIEESLQSYVDLECTKTLYELAEWVKCTLHVDVSTSTIDRAPREFHYTLKRVTLVLERRNTLSTIELRTNYATSFRELEVDNDDKNFVFSDEVGFAVETRCSRGCNMRSESAYLSVTAARTRNISVVAAMNKYGMIYHKIHERAINDEDLKLYIKEINESCQRQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK44</accession>
    <name>A0A4Q9LK44_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin conjugation factor E4 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2397p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002397">
        <property type="protein sequence ID" value="TBU07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2397p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="4">
        <location>
            <begin position="384"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="554" mass="64184" checksum="7EB93EC406064295" modified="2019-07-31" version="1" fragment="single">MSSYSHELSQILNQNFTSPLSQEECDDLLLSFIQSYTPTQTHQSVSLYLISKYNPHFPTPLKSLLSSYICLTLTDPSISINHTDYIINSKSLILITTLTDTLNDTYSDFLNTLYDINYSTHTPTIFIPILYQLSLLISQKDITHDTFKYVIALQNVLRIESVQSVIQDPIFWSLKTIKYTDIEKYNLNQIYTSCIINVRQSSNTNIYNNSNIYNNSSLYSNSSLDDNNSNIGVSVSIDTPTNIITINQYTNNNSQYTNNNSQYSNNNNQYGNSNYNQYGNSNYNQYNNNQYNSYNQYTNNNNNQHNQYNNNQHNNQHNNNQHNNYNHYNNNQHNNNQHNNQHNNNNIIHCLFFLPSFLEGFLEPFLYSRIPLTTPSHLLLNKEIQQIRHLNITLPSLQKELIKNVFNITKEIILKNKKIKNNFINFLHRMCINTRNRNKIQFDIFSNCSDGFCYNLSGILNMYCYKIVECNMYENIKREVIYNNTMIQGFDDSGVDVNGDRLGSDNIESNIVGSDDIESNIESNITDNISNISNNNITNNNISNITNIESNITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKR3</accession>
    <name>A0A4Q9LKR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2365p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002365">
        <property type="protein sequence ID" value="TBU07690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2365p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9087" checksum="2224DD5A4A86CE68" modified="2019-07-31" version="1">MLLQLLDLLISKVENTTTTHLVLKKNFLKVKYRLLEELKNVGDSFRWLKRGTLGPEMKQCRQNGDDYIKNHLVGNNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLC7</accession>
    <name>A0A4Q9LLC7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2330p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002330">
        <property type="protein sequence ID" value="TBU07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLC7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2330p0010"/>
    <dbReference type="OrthoDB" id="2191600at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="972" mass="110002" checksum="8D85BE6D30415276" modified="2019-07-31" version="1" fragment="single">GVNISTNEQHGVNTNTNSNPSTQHPFNNTPFNNNNNTPNNNNNTHYPFIFTDYSLPLILTLRIGKKVLNYTFKQDTIIIEGFYLQCTKINTSYILRIVEINRLEVLNDINICSNITVGYIYKVLFEHIAISVVSGVNEVMCIHLKGTEINLKSSKECYVSINDKSEVGGVNYKDSRKGVNYKSELGGVSNSKDIKLEGVNDKSNKLEGVSNKDNKLEGVINSKEQHPLNNNNISTNKQHPYNNSTNTQHPLNNNNISTNKQHPLNTNTNLLNNTPITDTHCCLDISIISIQIDNQTLECVYPIIFYPVNIKQRFFSESKDKRKFLSLSIGFYLESIIRYLTGDNNSSRDVEGVSNGKDVLEGVNDRRDGVVGVNDKYSNIKGVNNNTNTYNPLNNSTNTYNPLNNSTDKQHPLNSSTDKQHPLNSSTDNYNPLNNTTNTYNPLNNTTNTYHPLNNTTNTYNPLNNSTSYNPLNNSTSYNPLNNTTNTYNPLNNTTNTYHPLNNTTNTYHPLNNSTDNYNPLNNTTNTQHPNTPPHFTYIIFLLQEFVLNLEEDILTKLITFIPTYRNNTNYSYLLCNNCNKNECICYTYNSTSTKYTSSSTKYTNNQCTSTNTKYTNNQCTNNQYTSTNTKYTNTNNQYTNNQYINNQYTSSSTNNQCTNNQYTSTNTNNQCTNNQYINNQYTNHTNTNQHYHTHYQQHYHHNNITIDTLHLHPLKLRFSFLKSTKNHFISYLLSFILQNISSLKLKFNTFLITNIKDYKILIELIINSYKIGLISQMYKIFGSLDFLGNLSSLVDSFSLGVHDLFYEPYNVLSNSNSNSIDFSIGILRGGKSFIKNTLSGVSNTVSRVTSSISKGVSLVSLDKDFNEKMNLSNNLIFYLDDELLFPDKLVFTNKYDRFVESCVSGVRGIVEKPMEGFKKGFRGFLVGVGKGIVGAVAKPVAGISDLACSVSEGVRDRVSGGEVVRIQYTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN04</accession>
    <name>A0A4Q9LN04_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1292p0020</name>
        <name evidence="6" type="ORF">CWI38_2117p0010</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="PITK01002117">
        <property type="protein sequence ID" value="TBU09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001292">
        <property type="protein sequence ID" value="TBU11268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN04"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1292p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2117p0010"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033829795" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="33670" checksum="9B2E5A3AE469FECA" modified="2019-07-31" version="1">MKNYILIFFLALYFLFKNIKNILPCTFIDQPGNFLLLTAHPDDESMFFAPTILNLKGNLTIMCFSTGNYLQETESEMNMTKKEISEDKNNYFANNFMKIEKRNYEVKRNKIRLKELKNVCKFLNRNNKFIQNKEIINRNYLNTKCIILNLQDNSDWDTNEIVSIIRFYNLIYNFNCIFTFDRNGVSNHKNHISLFFATRKFRQEIPVKCYYLNSKNIWYKYFIDFSLNKNSFCSGIIKYFTSIRMMLFHKSQILWFRILYIFFSNFMIYNDYTDLDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPC5</accession>
    <name>A0A4Q9LPC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA replication ATP-dependent helicase/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1951p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001951">
        <property type="protein sequence ID" value="TBU10194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPC5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1951p0010"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="368"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="467" mass="54041" checksum="445CBB79360126D5" modified="2019-07-31" version="1" fragment="single">IENMHANEEIKEKFMIPECFKKEFNNLNHQQKMAIHLALNCDNFHLIHGMPGTGKSSIIAMLIEILCHYKKKVLLVCYTNLALQNVILKLKSVSIYRSKKESLNNFKSVNEIKEYFDKINLVASTCYGFTDPIFVERTFDYCIIDEASQQHLLLTLIPIYMSKRFILVGDHLQLTPLIYKSKELGISLFEYFISNGYERIIQKIKSRIEVKNKPKIVSSENSDCSSLENFDFLTSDNSDFQTNTSERKELNKIEFDNGNSSLKNIKKNDFKNNSIVNNHMCVKNSNKIDFNQMEFSNSSKLFSSENNSFDENFQNKNVTELTVQYRMCQNIMKISNSLFYSNKMSMGGKHTGYSKFIDSTNLDSIKYFKSIKNCVVLCYFNTKVHELRKLVDKSVIVETVDRFQGSESPSVIVVFDPIVDCEVMNSRQRLNVALTRAKTELILLGNRLLMEKIPVIKKLLDELQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPL6</accession>
    <name>A0A4Q9LPL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1807p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001807">
        <property type="protein sequence ID" value="TBU10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPL6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1807p0010"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1057" mass="122545" checksum="F641AB39B2F78B3C" modified="2019-07-31" version="1">MFELFRGRFYRGLSERVESEHVVYRDEISEFWSTMLNKNDDIVTSDDYLILFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLKGTTQADWFYCGLTYLIPKEIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLSENQLGAVRGVQGAKEQDLLNIGINKEYGNNLKATWIDVKKAYESIDHAYLSQYIENLHLPDWILKFIKMIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTIKTDTESQATNHLLFIDDLKLLAEDGQTLQEMTEEVIKFMNNIGFEINKEKLATTDPCCEDTATLFEGIGVYKYLGMLEDSRGIPKSKSFEELDDAVRAVLVKNKIYLRPGCKERLYIPRKEIGRGLHSKLEEAQIANLYNEIKNRKLHSKLYSARNNELVSVIDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGADGMCQHCGKSGKTVDHLATRCEKMLGRDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRCNRPDIFILDKRQNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVDIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERETLIDNEEGDVKTENTKNILPLILDGITTAKEPSTNTNEELELEEEIEVVEMCENDNVLKCLVETSGSNDENLSITTIPTLRKQKVSINDRERIIEKTLEGYSIKEGDRRSKLPLEIKESLQTYVDLECTKTLYELAEWVKCTFNVDVSTSTIDSALREFHYTLKLVTLVPERRNTLSTIEIRTNYATSFRESEVDNDDKNFVFLDEVGFAVVTRPSRGRNMRGESAYLSVTAARNRNILVVAAMNKYGLIYHKIHERAVNCEDFKLSIKEINESCQRQRILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSSFLNPIENVFSVRKNKVIRSGVRTEPQLRILICRKFNEITGEHCSSFYRKMLGYLQKAEVGQMIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU3</accession>
    <name>A0A4Q9LPU3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1812p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="PITK01001812">
        <property type="protein sequence ID" value="TBU10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1812p0030"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="26956" checksum="9B06E0C35BF889C7" modified="2019-07-31" version="1">MDKKNILHKVIRKHDDYIDIGIDEAGRGPVLGYMVFGAVVSSEVIKYKDSKLLTPSQRETSFKAIQENNNLSHIYFALHPSYITTEMQNKSLNEISYIAQINIIKCLEHLKIRNVYLDIVGPVSTHQKRLKTIFPNLNFIIEEKADSKYGIVGAASIVAKVTRDKRLLNWKFKDNNYGSGYPSDPETIKWLDRNFNPLFGYSDIVRFKWSTIERRLGIRKSKNVSSLGFYADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ07</accession>
    <name>A0A4Q9LQ07_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1710p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001710">
        <property type="protein sequence ID" value="TBU10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ07"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1710p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="3">
        <location>
            <begin position="302"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="711" mass="84496" checksum="CF03FCCC81C9FCB6" modified="2019-07-31" version="1" fragment="single">NLISDQEISEKPCKEINVGENVTNNSKIFFEQNEQETLKEVNYFKKKSETFESIHFKNKFVEIITDLDLKKFITKYFKRKTLFVMNYNDSNRKLLSSLLEKRHLIFKMNLKNNNFLMNSFNSILNCNLELLRLMCLKYRNILEISFYSKIPVLNIPINYKNHSTFSSNSSDFKILDDQINKDNSLELINNLKNNNEEQKIENLKINNEAHILHDEISSEILDFMFYKEAIKNNLLLTNEEYLDLSVLKDEYYNEGYNGSYCYEFECVGTLILSILEAEKFKNEDFFIQSKEFNVFRNFIKNIFKDSVLYGKTGKNSSKSIFNKSNDGLKNDLKLTKDEISNTKVFCDNNNSTKEDNIRCLIKKLQEYFTEPNKDYFYNAPGYLLGKIPIWIKKETKLLSKKFRQNLKILQQKYIIELVGKLKSMGVHIISVNKEIITISTGKLELSDAENYFGFLQNSISKIRNDKSCISTGFSFDGLTFRLLRIHKSMIYINPQCYFFLSTQNEIYSNCKRLKIPLSFLKMVLIEEKIENNYFYSLIMNKKIKNSEFIKSIKICLKIASYLKDISELKSNSFKMLRISEFEYKNNLNRKLKYLMFDILCKKCNTDNILRIHLQTEDNIFFDNICTKCYSDFDTDEIERVCMEYVYYKTDEYLCGETFCLRCHKYNERRLKEFCVCGDVFITKDYKKEFNVIKDYVNTKKMSDFIDHFMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ16</accession>
    <name>A0A4Q9LQ16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1705p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001705">
        <property type="protein sequence ID" value="TBU10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1705p0010"/>
    <dbReference type="OrthoDB" id="2186859at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031543">
        <property type="entry name" value="DUF5087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17006">
        <property type="entry name" value="DUF5087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="51924" checksum="D5A1D44249556DEC" modified="2019-07-31" version="1">MDKKLYEAILKIKKLEKELADKELLIELLIAELKRERGSKYSNKSIEDDITVKNSFFKDSIIEDESLKSNFDNNPQNIIKNYLQETETFKTNDDEIKNHNFEDNELFELKDNNLPYKTSVDDILEIFCEKKASPPQIKTNMSFEEFVYVCSNLQVSEPLEKYKEIFIPKQLIVFVENNLKGIIKYLFSNLEKWKPRDIYSVVTVLSTIKNDELKESILHDIIIFIKEPVLYIFYCYPFLLESNPNSIFIKTIKKILSFQMAVDIKIFKSYENILKILNKISENINLKLEIFSIESYCMELVKEVPIFENGNLNNEALLIGASIKLICNFMDWDWTYNQFIVEFLYPKFIKTNSPSIMYYICLITFNSYKDFGNHKSIKSIFDKIQEYISNENIELSLVAYLFIRQTDSNICKDWIETNQERLKKHISVDIDFINKTIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ36</accession>
    <name>A0A4Q9LQ36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative subtilisin-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1669p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001669">
        <property type="protein sequence ID" value="TBU10579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ36"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1669p0020"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020762747" evidence="7">
        <location>
            <begin position="19"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="240"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="534" mass="60393" checksum="211F51BE76F40CF8" modified="2019-07-31" version="1">MILLFFLQILIEIYEIQARNFSSNIDIKSSIHDQDLDVHKPIIKEIRVEPLINDYKVDYDDNIQSLDKIINEKLVTTLPENSKEVCNLNTENKENSTEESILNTENCTDDFGDSIEKCYIVKAKSSDITKNQELISFLKSNNIKPTKTYSKLFGGFTFCTKNPNLSKKIKSLSIVSEIEPDLEYKINSVQSTIPFYMFLMNNLDNTIFKNYIINNRLFDLLGINTIFNYLFGSYTYNFTGKNIEIYVLDTTVDINDSEIKGRVSNLFKNDLCNTHGTNVVRVIGGKNMGFAKDSNLKILNVVNCSGIVKLSEIIAGLEKIPKNLKKPTVLYLSVNGPKSNLFNRIISKITENNVIVVSAAGNNHDIACNYSPGNSENVINVGSINQDEDISKFSNFGGCIRIFALGEEIDSNSNLGNKLMGTSFSAAIVTGAVAIYLEKFPNATQTEIWNYLNSNSIWNKNGYLALKIPQLDKETDSIESTKNIIPNQSTYGFKTMCLKYYFIGITIPIICITFLILIILYFIRRHRTRKEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQD1</accession>
    <name>A0A4Q9LQD1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1625p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001625">
        <property type="protein sequence ID" value="TBU10658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQD1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQD1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1625p0030"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="10">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27216" checksum="87744A447D37BCAA" modified="2019-07-31" version="1">MRLETKNSEITVWLVKVPNFLAERLHELEGDIDIGELEITSATENEPASVNIKFSEKVCGSGFPTSFHLDRSEVDKQMYMLKSEKDTSGIEAKVTTECFVRPVINEEYILYRKTRNEITSGPKRMTQVIDFNKDGRIGERIGSISELETMARKRKKMLMDKKRERLDKSHVMDMLFNAFEKHKFWTVKDLADFTGQPVAYIQELISEIGMLNKKDHKNTYELKPEYSYGRDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK7</accession>
    <name>A0A4Q9LQK7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1553p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001553">
        <property type="protein sequence ID" value="TBU10779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1553p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="31"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="38111" checksum="C6582E088FE9899E" modified="2019-07-31" version="1">MRFEYLIIIIYKTISSSKSRKRPRLDQNANPELENTTNICYFNSLLQCLYNSQSFFDFITKEKNKDSNGVTSNMRKVITYMSKAKEPIDMFSQLKNILYNLKKSDADNMLTQQDVSELFVFIIDKMFDETRIIGNLDKENFLQSIYTTKIIALFYSHFYCRITCQKCQNFNNRDEIRNIFYVEKAKSVQAAIDESTLTSENIKKDCEKCKISCLHKKESQINYQSQIITICIKIYNNNLQKINDKIFIEEKIVLSGTNFTLVGFIEHRGNFLSSGHYIAYASKNGTLVRFNDSSNKELKKEQKESILKKGYPFMLFYEKIQNTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQM1</accession>
    <name>A0A4Q9LQM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1518p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001518">
        <property type="protein sequence ID" value="TBU10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1518p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12302" checksum="6064DB0A75B01F63" modified="2019-07-31" version="1">MALIHSIKKATKTISDNRRRGLKLSLNSEKRTGKKRICLKIQNKKKLPNILDSATILEEENINMNEDLDLEKDNEVVKIVKILFKRKKNRETHNFIIMVQLISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR57</accession>
    <name>A0A4Q9LR57_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1450p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001450">
        <property type="protein sequence ID" value="TBU10978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR57"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1450p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="20724" checksum="B2E170F284E0A537" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANNADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMTLRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA3</accession>
    <name>A0A4Q9LRA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1545p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001545">
        <property type="protein sequence ID" value="TBU10797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1545p0020"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18656" checksum="6445FB9C10590341" modified="2019-07-31" version="1" fragment="single">MTADILKDKNKVKEIKSENLNENQVREMKNSNTEVRDNKNLKDKEARDNGVRDNGVRDNGIRDNGVRDKNKVQEARDNINVDNSSSDIDRPTESRERRFIFMKEEDNDIKIEHKQNIEDDDNMLVLKGKPVSMQRRVTIARGPGGIPILREIIIIETEASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG8</accession>
    <name>A0A4Q9LRG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Heavy chain of myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1343p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001343">
        <property type="protein sequence ID" value="TBU11173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1343p0010"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2106"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="61"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="902"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1816"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1485"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="953"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1819"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1850"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2128" mass="245477" checksum="8C16F02EDE15D727" modified="2019-07-31" version="1">MNKTKPSPQKKWIWIAHPTKTFTTAYIISEDTTTLTVETQENKILTINKELTYKMNPPKFDNIDDLASLSYLNEPSVLHNLATRYYNDIIYTYSGLFLVAINPYKKLKIYSSDTIREYHINKPQDLPPHIYATASQALRNMLYNRENQSILITGESGAGKTENTKKVIQFLTTIAPVIEKGQSEGIEGVDIRDINNTRDTIDTNDTIDNTINTIDTRDTRDNINYLQSSFQHTIEHQIFMAHPILESFGNAQTIKNNNSSRFGKFIKILFSNSTITGAYIEKYLLEKSRVTHQNPNERNYHIFYQLLCGADQSLKDKLLLEGDHTNYTYTRGSSERDSSESKRDSRRDNSSSESKRDSRRDSDSRRDSDSRRDSDSRRDSDSRRDNSSNRRDNSSNTRDNNTHNNTHNNTPHINNINDSNDFITLNKCFDVLKITEEERLNYFTVISAILHLGNIEVLQHNDQAYINNTETVEKVCNLLKIETKKFLSTLLHPISMAGTEKVINMRNKNQVINIIEALSRTLYERLFDTVIDRLNYTLNSKLDSNKFIGVLDIAGFEIFKNNSFEQLCINYTNEKLQQFFNHHMFVLEQELYKQENIKWDYIDFGLDLQPTIDVIDKSSPIGVMSYLDEECVIPKGSDKTFLEKVISGIKCSGGDSSRMGDSSSRGDRDSNYRGVNNLSDKQQGVNTSSKKQQGVNNLSDTLHPVNNNHIEQHPLNTIKHPSFNQYGNIFGPLRLKNGFFIKHYAGKVEYLVDGWIEKNKDTYFDSLSTLLLTSTNLFIKDLFDCYISSTKKGFFRTVSQRHKEEIYSLMTQLTNTSPHFVRCILPNIYKKNYNFDLSVVLQQLRCNGVIEGIRISRLGYPGRMTFIEFKKRYSVLIRKRSKIVNSDKVEGDMDLVEGDMDIVEGDSNSRGIVEGDSNIKGDSDTSNKQQGVNNSTNKQQGVNNSTNKQQGVNHTTNNLHTLTNKQHPLTNTTTNNTTNHLTLKDSVFLILSTLNIPTNSYRIGITKVFFKQGVLGDLEDIRDNIIISLSKEIISLYLKVLVIRKNNKKKKNEKNIKILQKNLKILLNIKRWKWFKLYIKIKPLFVVTHYELESKKLKDIIYNLNIENNNYKSYNDKLNCNICKIEKELESSNKLVEEWKDKLLYLRGEYESRIVLLESREKEYESRIMLLESREKEYESRIGEYENSNRLLESRIEDHTNTIKEKDTLIKEKDTLIKEKDILIQDLNTNIEDHIKIIKDKDTMIKDRDTIIKDKDTMIQYLNTNIQDYTTSVNNLQLLLNDKTSELNTIKEKHNLTLKELKDKEMGNRIVEYESKIVGLESRIVEYENKIVGLENSNKEYEDKNKVLEDKNKVLEDSNKVLEDKIEELSNTNISLSNTNTTLSNKNKELENKNKELENTNLSLENTNTSLSNTNISLSTQVTDLSNTNLSLSNTNISLSTQVTDLSNTNLSLSNTNISLSTQVTDLSNTNLSLSNTNISLSNQVTDLTNQVTSLSEVNKELKNNYNFICDLKGEEVEEVKEENKVLNKRCNDMKNKVIELEEDNKRYKDIECSNRGVISVLECKVDCLERRCLVLSSRYGSGNRLDNESNTNLYNNTDNNLYNNNLYNNTNNNLYNNTLYTSVLGSVDRCLRVVEKWVGRCVRGYEEVYRRVLNEYRERVGVLEKEINIMKIKVEGVNKENSRLRVLISSMNLSSVLRGVSDVYKCYIELEVLISRYVKGVLSIEGECKVLGKEVCDKRGVIIELESVINKMERGVSDMVSMEDSVEDSIGMLSVLEGGDKSRGMLGGVNDNYMLGGVNDKSSVLEGVNNKEYDYKGLSNNTDTYHPVNNQSNEQHPLNISSNDYNPHSTSNTDIPNNNISDISNNNIRDNNNNIRDNNDISNLLYNHQPSSNTNTNTNTNTNNIFVLLGIERENTKILEMKNRRLSEYCMRVVKENEKYKNININILIREVLISRNIIRGKSITIKNMKNDIEVLRRENIRNKEYISEIERDMCIKDGYKSREGDYKMLYFKMCGDLRVMREEREYMKGRVFCMEEDIYRMRMCVVEGEGRVKGLVREISEEKEYNEFLRIRRLGVRDKRSDKGLGRLGIRGLEIGEYNGYCTLYLLVPVLVILLVNILVLSCFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRJ3</accession>
    <name>A0A4Q9LRJ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1997p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001997">
        <property type="protein sequence ID" value="TBU10135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1997p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22501" checksum="BA46514CBBBE89D5" modified="2019-07-31" version="1">MKFEEARLKNLLNKIVHNAFQNYKIQEKEIFTCDSNYSGRLKKENIKPNDEGIFFYAHDRNVFWRAEEIFQFRNQSNKTARRDNKNIGFLYLLLLNSIPKNSVSRMESNDEIRNITDFLVSAQEKKYTALLKHSINIYENVKEKKNPQKTHNNTTNTNEEKRISKVTLNYYETPKTNLFSKIQNKFSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL6</accession>
    <name>A0A4Q9LRL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2007p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002007">
        <property type="protein sequence ID" value="TBU10120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2007p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="332" mass="39671" checksum="591B6B20CD6F3D9B" modified="2019-07-31" version="1">MVSFIKAKAITNNYWNIVIDILECSLYTYEEFNSYSEEIDKLILKNLNKKIGVDQSFETNTSTQCFFREDLYFKLTNYKNLLVHKSERYKYYLYILSKIHLKLFIQTKSENEIAEVYQNIENNICKLIVNHVSYNAVLFNKNVEITDENREDSKINLDKFNQNSKLHIPSFVIRQLFLNDSILASGYHIKVKYLNGTFDSVPTISLEDSNNKEYKYILIKMTNYFDLKIKIENLPWEFNNNDEFVNEFKDKEFNLIFMFKTNNIIEVSDFTVEIILYGMTWNRIVTKYNNTYLKRLQIPMNVEAYTYTVEEPKIPIKIETDFYENHLVGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR0</accession>
    <name>A0A4Q9LRR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ring finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1565p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001565">
        <property type="protein sequence ID" value="TBU10756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1565p0010"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="301" mass="34536" checksum="0D8B5180EA927300" modified="2019-07-31" version="1">MLVLKGKPVSMQRRVTIARGPGGIPILREIIIIETEASISSILRVLGVLFLYALLFQTVFSLWNKFHKKSCKFTIFGILWLFPPLFSIFVKDYIFFFLCASYSILILQSVYKILKKPMPKKVPRDTYKLFRSLFFTSYIGVILGHILVIGSLFKILDLLGLGIIILAISLYFGLLSREIIDVLSEIMAVNLGYYSKDGMPEKALKNDVCSICDTDFSSTSERTHTLVCGHSFHELCIKGWCFISSKEFCPCCREKVDFKSIPADLWQKSELFFSYLLDILRSFIVFCLCVVVMTMYYKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRS1</accession>
    <name>A0A4Q9LRS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1556p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001556">
        <property type="protein sequence ID" value="TBU10776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1556p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="129" mass="14616" checksum="487401066E3DAA77" modified="2019-07-31" version="1">MECGMVRCDSREGGVNDRDSLEGVSDSNGLEGVNYSTDTLHPINTNTTTFTLWNSFVFGDYTVVFCTFYDNERFKNNLEKFISELCCKKEGDGVIYCGVECLFDIDGDNFPEVVVDFRREKGEEVNKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ5</accession>
    <name>A0A4Q9LRZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1281p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001281">
        <property type="protein sequence ID" value="TBU11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1281p0010"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="243"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="114"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="330"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="580" mass="68046" checksum="7EFD6681C0624899" modified="2019-07-31" version="1">MYFKDKDSNINIKIDQVEKIFNDLRSRLVFMNKEIDNIGNDSFLKNIDVENENIKNTPKTLIENCSNENCGCHMNNCDNLYDTNHNLKHIICDQNKLETNDLTKEKLDTLYVFIDELSMKLKQLESEIVEKNQEIVNLKEENENNDLQHKYVIESFKSENNKYLEEIKIKNENYMKELNEMKNLLKNKENEIQIKQQKILDLQENKSVLELKLKNLEKMEEKIEIFKMKERKLIEEIIDLKGAIRVFCRIRPKFYKNTDSKNYEIEYSDDKITIKEKIESSYNNFNIKTHNFLFDKVFGPECDQLQVYDEISFLIRSILDGYKVCIFAYGQTGSGKTYTMDGIEDNPGIIPRSVSEIFEVSKELSKNNWKFEFIISFVEIYNENIVDLLENNTKKCDIRHENDETYITNCTYKVIETLEDFTRHFKKALENRTTGVTFVNERSSRSHSIFTLKINLCNSVTNQKRQGILNLIDLAGSERLSESKCEKIRLVETQNINKSLACLGNVINSLIKKDSHIAFRDSKLTYLLKNNFLGKSRTIMIVNVSPDWMHLNETICSLRFSSNVKQCRLGKATSNVHKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ5</accession>
    <name>A0A4Q9LSZ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">CWI38_1081p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="PITK01001081">
        <property type="protein sequence ID" value="TBU11689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1081p0030"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="405" mass="47356" checksum="E330D52F6C6F5D19" modified="2019-07-31" version="1">MVEVESINEIITVEAFIVSRKELNDVMLKYNKVLLNKPKIPNIIDLNKEYMTFSVIDLQKKVSKDKVICLLNSDFLDDDDSDFFGAKNPNILLGSCKIDVLESLGCERPEIYSWEFTEIFDLKLCLNFNYFSYKEILRKILPSNCKIPTSFEIIGEILHLNLTEDLLIHKKIIGEVLYKKIKNIKSVVTKIGNISNEFRFFEMEVLEGDHDLNTKQIENGLIYFLDYSKMYWNSKLQSERKIILNYFKPNETICDLFCGVGPFVIPALKKGCIVYANDLNKDSITYLKKNVVENKVHSSKIFIFNENAFSLIKTLKTQNTTVNHFILNLPEKSLLFFKEIVSLNFNSMIHCYFFCKEFIQPWEFVYNEISIEIPKSNFEMIRSVSPSKNMWKITINLHEIEKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT27</accession>
    <name>A0A4Q9LT27_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1111p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001111">
        <property type="protein sequence ID" value="TBU11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1111p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020498664" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="32549" checksum="8FAA43DCCEC06615" modified="2019-07-31" version="1">MQMLKYFEILLFCSSLCCSTSNDTSTDNKEYKQIKHITLQFNNLEHFDNIYVFIRDNLSIFSDLIPISPLHVYMCCIESLNVVAWKELVNMKDVFNYTSRNEDVSMEGNYTKIIKLNDDEIPFVKNRDEEYYYTFDSERTDKQERITELANYIHNMYKNLRNFDNMNQNLDSSANDYQKNDVSFEKNLLNKKIIILLSDSEPGIKDTEKIQRFLQDYNEEENNTLIIYIFENTFTKISEKICHEMSGNYLDLYQYRYSTTRLYSNRQIMGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE3</accession>
    <name>A0A4Q9LTE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HIT-like bis(5'-adenosyl)-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0995p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000995">
        <property type="protein sequence ID" value="TBU11888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0995p0030"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16840" checksum="51106E18E518E95F" modified="2019-07-31" version="1">MKFGTHEIPEDHIIFKTKYSFVFTNIRPFLPNHLLVSPIAEKMRISELTKEENEDIFETVRKITTVLSKIYEGFTINVQDGVSAGQKVLHVHVHVVPRKNKDLKYNDDIYKEGALDYERVERSYEEMKQETLYLRSLFKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL6</accession>
    <name>A0A4Q9LTL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0962p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000962">
        <property type="protein sequence ID" value="TBU11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0962p0020"/>
    <dbReference type="OrthoDB" id="2187855at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10337" checksum="BDA81B06A761941B" modified="2019-07-31" version="1">MLNDLQNEVNQLLFLYFTTIGFKENVLPELLKNITECKQRIDEILEIKPCMDNENYENTKFYVDIRETVNKAKCFVNDGLEFLNKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN4</accession>
    <name>A0A4Q9LTN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DUF4451 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0951p0010</name>
        <name evidence="2" type="ORF">CWI38_1325p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001325">
        <property type="protein sequence ID" value="TBU11202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000951">
        <property type="protein sequence ID" value="TBU11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0951p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1325p0020"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF2">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="1">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22645" checksum="444EF38B35E4A293" modified="2019-07-31" version="1">MKNTNYTYLDDFINLEFRNLDSSFNSLELESTDDIFHFQEYLLDKKTINEYYHSAIQSLNNEVFLPTIDTSVFKETSKSVVNDTNKSDKKNYSPKFVRGNGIMREGYCEECDKWFRLKTSSYWYHMNYKHGVNSSGQKYPHPNIQNNCGYYEALCESCQKWVYLGKKNNNKSINFCWFKHWQKDHDKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ0</accession>
    <name>A0A4Q9LTQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1466p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001466">
        <property type="protein sequence ID" value="TBU10940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1466p0030"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="718" mass="81320" checksum="C423811B79AFFFE9" modified="2019-07-31" version="1" fragment="single">NNSSDKEDPVNNKDKEQDPVNKEDKEQDPVNNITNTLHPVSNSTSNKRYKCVKGNKGVNNNDTNNNDTNNNYTNNSDITPYDKGVNNNTLSYHRLHPLSLINLILLREQCLDIIIDSLDIYFNDSLKYLKYFILSPSSLHRFIDSIFIFNKICNNKIKEENKIYRGVINKESGEGVSDKKNRVEGVSDRSMLEGVNNEYDIKGVNTSTSNYKGVNDITSKQQGVNNVSDNQQGVNNTPDTLHPSNNTNTSIPLLSINYSSYVYDDLRRVLSIIERIPYSITIEGVLFKKILKTIKNNNNNSKGNDTYICFTYEDLNILSVIFRMSISKNKKRKLLKYWRISILKCLNRFKSFLSSCCDVLEDGGVFEIVVRFVCDLKGFKCLLEDILYLVLSYKVGGITNIRGSIGDIRNNNIDDYRGVNNSIEDYRGVNNNIDDYKGVNNSIEDYRGVNNSIDDYKGVSKSIVDYKGVNNKIHDYRGVNNSIDGYRGVNGNVHDYRGVSKSIVDYKGVNNNIVDYKGVNKSIEDYKGVNNNIEDYRGVNNNVHDYRGVNNNLHDYRGVTTSTSNYKDVNYNNPINNNLNNNTTTNTTNNPNLNNSDIPYSTINTPVTTYYNNTFNIHNRKPSDLFNIFKILMKNVFNKKGVNEERCSILLKGLSITGYSDIINKGVINRGSGLKYVRGVNNYINGSIKGVNVKGSVRVLSNITSIKGVNYISSIKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU94</accession>
    <name>A0A4Q9LU94_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">CWI38_0850p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000850">
        <property type="protein sequence ID" value="TBU12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU94"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0850p0010"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="35855" checksum="94C66FDED1216544" modified="2019-07-31" version="1">MSEIYKARDILNGNKYNITQKMRALFYLRNINTIESVLIIISAFHNESVLLKHELAYVLGQMRNPSCIATLKNVLRNTEENEIVRHECAEALGNFLDKKNIEFLKSFYEDASIPVRETCYLAVRKIENHHQLNNKIEVETNENSINEYSVDDFVKFDKIEISEFDSYDPAYPLIIDDYILESIYLYHRDIYFRYGAMFSLRNKKNVDVLVKGFIDPSALFRHEVAFVLGQLRMKESIPHLKAVLADENEHDMVRHECAETLGAIGTDECYEILKKYLQCDADIVRESAEVALDICVYEMSNDAEYCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF1</accession>
    <name>A0A4Q9LUF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1013p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001013">
        <property type="protein sequence ID" value="TBU11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1013p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020663624" evidence="1">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="41296" checksum="B86D829C85585551" modified="2019-07-31" version="1">MIFSSKIVLKILIFVFLIEKANTSNNNCENEIFELKQLEPASKYYLNMISYYITRLVLNGELNMNRGSELDYILNNAIKRYPRNVENHFVKFMNLEWNEKHQAYKSKKFVGKNCFWKFLPVLIYKLKNTVLKSIIDKYKITSDYFSKEIENTPQWKSLDRNDFIDNKIKKVREKLSLFIRNSGNNPNKSSSELIYDDKFCRNPNNREYLFENQFLTENAEMNSENLELLYSFELNEMYEKNLLNDLFSKFKQNFYFKNILVDVFQEIGISSYVFTYDLSRKKKRKLQNSIAYIYTHDKYFQECFIIYLSNSLKPHLEKYVKAMFRTIEEFNLTNIFLMENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG2</accession>
    <name>A0A4Q9LUG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0856p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000856">
        <property type="protein sequence ID" value="TBU12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0856p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="294" mass="35312" checksum="B0568AEBD276256D" modified="2019-07-31" version="1">MDYSTSSFASLFQENIFTGKIKIFEFLDLKYKLWEISCQIGCFIEFFDISIIFEELDLNEFKVKGTFFERNIRKIIINDSKINSSFLEDILDLYKLKRLKIFESEISLEKTMNINNNTIECFIYRAKCHESCRYFYELVNLMTNLKRINFLMDRRINLRWPDAVKINIRHFEFLDVFLYKEYIDISEMKLLSNFEPKELLHLSAKCETGSLKCLFSRNNFSQVKKLNLSRFVIGNEDVKVFKNNLNSENIKFFYINLRLISISDLFCNAKDYNIKYIYLSNIYVSNQIWNLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI0</accession>
    <name>A0A4Q9LUI0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0944p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000944">
        <property type="protein sequence ID" value="TBU11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0944p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF35">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="56441" checksum="35BF3DFC1194872F" modified="2019-07-31" version="1" fragment="single">MFKLRTDPETLNIVQQDDYATQKNILTLIFNSYEIYRIKISVDDKYWAEGTNPVIESNASEKCLTISEIKNGFSSIFFNMNLNQKRSIKSVELERIVLTIKDMEFLNDLKVLETLVIVHCNLDCCMDFLWLLPSSFPKLKILGIIGYTLKNNFFENINLMNIRILNLSKCDYNDNPNNLIVKKNKYLNSLKMNSSCLNQKVFKSMICSDLLIDLSLRAVDFTEIKVDKDCFDRKKTFQFLDLSECKFNDEFLDYFLTDLKAKKLNLEYFPDFQHLIKILDQESLHLSTEFLSLSGNSLYVDLYISVSRFKVLKRLKLSHMNYMICNDFHPKFAFKHQLNAIDLSKNRLNKDSMIFLHQFNNLKELNLSNCNLETGYMEILFTEHLSNSLVELNISGNSFVSSDFFKIVYLKNLIRLTVSFDNQVFLNLEDKYDIWKFKKLRTLILVQTNIEDLLYKSVMTIKDIKIIEFQNCKFEDDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK3</accession>
    <name>A0A4Q9LUK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0832p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000832">
        <property type="protein sequence ID" value="TBU12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0832p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="196" mass="22665" checksum="194A6F4CC691E80C" modified="2019-07-31" version="1">MGIGGYVILKGFKMGMGMACWYAFKKYVIKGVLDTGIKEGVIYRLKKWKIGCILTDPNKTVNKLVKHFETHLDTSIKNNLEDRIIDYLTIMNLKNYKTPRKDKITADFLNKKNKRKKYLTSNISNRFNIKDLKQGDTFWRVLFNASLEGIICKIKKYIDGPILNAIMQYNSYTGDLVVIERKPEDIKSSLRILPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ3</accession>
    <name>A0A4Q9LUQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0776p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000776">
        <property type="protein sequence ID" value="TBU12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0776p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="52441" checksum="4459E83EB2335EA9" modified="2019-07-31" version="1">MHPSLMKGRIFLCFINIFVTVSLLLQIVIIIFIWINIRSICIIGHLRQEMMKLQISNDSLAKYFIQNDSFLLSMINLNNRNVCLLVPIRFTSDYYHETTFKDFLKKDHEYIHKTEVNKIVNMINGLDLKGLKEVILADSLYRNEFLIGFIKKYFYYELPCYKYIKFYEEVSKVFTYSELNTINIIYFTTKSEINIEKIKIKIKKQPIYLDHVLRVDDIKKILNNPDAMKEYENFRKNIANYRDKKHKMIFDKIIKRQAIGYEKLCNLYVNLGQDMKNVLIFGQDFMFPNCADSPSNFVSKIKCLKRKIRKVIISLQIKPFTSSFSNQETLNRICSDIRTLSCLINENSETIAYLALKSSNKLSSLIDSIKRKLDEFNNILNKYFFKYKKIYDFVIQKELIAKALYLFLKKNCEIQPTNHNIQIKYPEETFFSLWLRYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUV0</accession>
    <name>A0A4Q9LUV0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0931p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000931">
        <property type="protein sequence ID" value="TBU12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUV0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0931p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="16102" checksum="DD275FB386E71530" modified="2019-07-31" version="1">MRDFPQPKKDIITGKQNINSAGHIHIFVTNNLQNVIDNISISIPLLKCGHSKSAEFYYRLQNITESSKFIESSEQQKYKGFWADKQYFMGSNATNRLKAIGEWRNYFRVTDFTSEVLKDIRSSSNDPNFYKFLVEQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV76</accession>
    <name>A0A4Q9LV76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0870p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000870">
        <property type="protein sequence ID" value="TBU12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0870p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="26389" checksum="5FADACB075356362" modified="2019-07-31" version="1">MEKINDMEFNNDLERENKFKEIVSKHIKTLNLEEPNYENKEMFYTKEEMDRFNNIVLKTNEEKKQKEIARNDKNYKKNKENKSKKNKKYVQIDDYVEGSSKNEIKKQKDKECDTKDSLKTKGKKIEAKESMNRNAKGSKKRKNDETNETPKNMKARVDEPKKRKTDKNLKKSVEKNEKLKKENSKVNENSSEKKEIKAKKENTNKKISMNKKVKKEKSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV85</accession>
    <name>A0A4Q9LV85_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1148p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001148">
        <property type="protein sequence ID" value="TBU11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV85"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1148p0010"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="457" mass="51815" checksum="401B64C76CA9B1A3" modified="2019-07-31" version="1">MSENPKINLKDIMSARFQNPKFVYDGKRMRNMAIRKAVDYSSAIIYHRNFTKNIPIQTTSHYDVSDHIIALKLPHHHVSSYNYSSYGTSEITNSSFAQENQVNETDQNSNQRTSMNTHSTAYDTTFTLNTKFAHASINKTRCPVNTLRWTPDGRRCISGTSTGEFTLWNGYSFNFETILQAHESAVRSMCWAPSAQFLVSGDSLGTVKYWHPSMNNIQIIQAHNESIRDICFAHSDSKFCTASDDGTIKIFDTKDCKEESSMSGHGWDVRVAQWHPYKSLIASGGKDNLIKLWDPRMHTEILTLHIHKNTVLALKWLTRNSSDSVCNYLLTGGKDQVIKMVDIRKFKEMCTYKGHRKEVTALCAHPTINNMFVSGGAEGTIYYWQSFKEEPVATTTEHEGTIWCIDYHPLGHIMASGSVDQSVRFWIRNRPGLGDGESVEVEDSEEGVNVQRIPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV90</accession>
    <name>A0A4Q9LV90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0735p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000735">
        <property type="protein sequence ID" value="TBU12494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0735p0020"/>
    <dbReference type="OrthoDB" id="10307184at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21899" checksum="63797CE3B53D6223" modified="2019-07-31" version="1">MLLFLISLVFGGEFLYNFKKVDKIEENYELFKEIKLKTFLYKFYRTGKSSTKLLIQQHLPFLLQEVTKIKSLDFTRQSLIFTLTPYKDIFMKDKNTTICIGKYVGTFFEDDTLYQYYKGGDKCDIKKDVNRSARVSYKGGPGKLRIDKIYESKVCRYEIVVIGEELSRVVEGNVEIVYFVEENDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM2</accession>
    <name>A0A4Q9LVM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative CHY zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0642p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000642">
        <property type="protein sequence ID" value="TBU12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0642p0010"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="275"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="371" mass="43569" checksum="94E6D35EB583342B" modified="2019-07-31" version="1">MFNYEKLLENHKFERNEDSITIELNIPEDFIYEISSINVIFTNCEVKLLCDEIPENIKENIYRFYKNDVFLFITFLEENLEVFLSGKIPKIDYNSQINTNNSNMSNIKENRNENNKNICKPAILLPDDYFYPINDIKSFNISYKADKKNIALLLAEKLNIKVLCNKCKKHYNIHSRLICDKCNEMLIYEYFSTLSDQFFGFIKLENCTFIAFNYNSYVINCLTCSKIYRTTEIGINTQFEFKCSGCHSFISLTLKDIQYKTYQKSLSSKIKVGVPLPENGTCIHYRKSFRWFRFPCCNKLFPCDICHDKETDHCNEMANKMVCGFCSKEQSVKNNCECGMTMKKSTAHWEGGKGTRNKVVMSKKDNKKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT9</accession>
    <name>A0A4Q9LVT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0737p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000737">
        <property type="protein sequence ID" value="TBU12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0737p0030"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="467" mass="54717" checksum="C586713B306CF389" modified="2019-07-31" version="1">MLASILDISINKIKKGPIILTKCVQNDDSVISIFVKNGSSNENQNNNGISHFIEHMVFNGSKKFPKNITNEILNKKFSYYSAYTTREYTNFLFKTKNLLETISFIFNILRFPRFNTKDIENEAKTILKEHESVNSNLIEKKLDFVHKKLFKNALGYPILGPVSNIKSFSKNQLKKFHLTTYKPENFLICVSSKYTHNQILEIIANTFYKSKKSKKFESNIFLDKNIKFDNIVNSIKSIYKDLKKINNEGDNENNNCEKLKELYFVEGKEYKEIEENKGINKAGDSNNEGNIDDKNKFYTDESNLKNLNEIKNSKFLKNSEISKVENEVINKKRMIIKKNDIVGIKIGGYKNILHLHILILCKILREKHNLNIFYIPYEKRGILLFFKEDDNLDIKNKIITFNELESTKKVFLNDIYSIFNSSKDFFDFFGPEILFKMNLLLYSPHIINYINLKHINLFKEKIVEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW74</accession>
    <name>A0A4Q9LW74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1004p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001004">
        <property type="protein sequence ID" value="TBU11870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1004p0030"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="31789" checksum="10E2EE7403A82DC0" modified="2019-07-31" version="1">MYLQKKNVFGVAIIVLYQIIFLYSVNCTNISLPNPVDLDVNGVSDKYKPIKLLGEGAQGKVYLAENMRTKEKYALKIQKIQLSAFFHTVSLFKKYLKHENIVKFYASNKDKTYEYLLFEYLPITLFAHLKKCKETVGNFMLIMKQMLDVLNFLQNQKIIFMDFKFDNVMLEDDLKVKVIDFGMAVVTSEDTDYSHLPKIDLKKNPEAAYLAPERRNREKYGCNSDVYSFGYCSKMYMINILSQNDSFSRDGNDFFKKCLEDDPEKRITADLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG8</accession>
    <name>A0A4Q9LWG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0561p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000561">
        <property type="protein sequence ID" value="TBU13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0561p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="305" mass="36520" checksum="847034AEA986E91B" modified="2019-07-31" version="1">MPSFTETLLQKFKKYDTTLQKLCLLRNKHSTKETSEQLKKYIIENDTLAALNMYIQISENTEFIDNETETFILNNLQTYFKFNNSKKIQKILQVVKNHKNREFFLKARSLFINFILQTSKMIISQNNFLPSRHINVLLNLQYNYDPLDNYESRKIVLCCCEEVINNFLYKEDVLPIKGNNNTSLYLDSQIKNKQNYLLDPSYLIYLDAYIQELCNIRRVLNNYNLSTSKLISLLNSRYSEQEIKYFKVCLSKNYFINFLTDENQKNDFVFLINKILKRNEFMECKLKDTIIECCYGNYRLIFKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM4</accession>
    <name>A0A4Q9LWM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0919p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000919">
        <property type="protein sequence ID" value="TBU12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0919p0020"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="163" mass="18740" checksum="967AD444105696E6" modified="2019-07-31" version="1">MRRGVPSSARVRLLLKKGDKGYRCRRDGCRRRKSVRGEIVSSEISVLSVIIVQKGDTEIAGVTDRVESCSHLPKRASKLRERFEIPEGADIKKFLVESITKAAKESGQEKVKIPRIRITGEWTQEKEDAKNAIKKEAEERKKRSKTQREEFFAKYPELQQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX07</accession>
    <name>A0A4Q9LX07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0849p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000849">
        <property type="protein sequence ID" value="TBU12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0849p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17128" checksum="2D5C065C743EE1E7" modified="2019-07-31" version="1">MGLIYKYSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTGPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXB3</accession>
    <name>A0A4Q9LXB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0570p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000570">
        <property type="protein sequence ID" value="TBU12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0570p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10210" checksum="F5318B042AEEFEE5" modified="2019-07-31" version="1">MEKNSDEILEEQLEFVFKDFPPLTNENIVKGFLNRRVGIGFVMKDTKFDKNFVKNTKSIKNEVKNEEDSKEELAKDSFVKSKKKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN8</accession>
    <name>A0A4Q9LXN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0420p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000420">
        <property type="protein sequence ID" value="TBU13474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0420p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27900" checksum="5CB965B589F3945F" modified="2019-07-31" version="1">MLNTREKEDEKTFLIAFKEIYGDYPATNNGYQTFLIDKRSEFRALSKAFGISSVFLFRSNFFIKKYSSKLFDFKDNFRIKLKRNYRNVFYRKMDFLITLDTHSYYKSDVAIFIGYNKCDFEFFYDKNCKSPIPDCLIDFVDDIEFIDSEILELYQLFLNYNPSSVVLFFDTKMEKFLMFSYSDTNLFKKNSLENLTSIQEVKLDTPIRLKNIDIGFENILFDIQKPIKPRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR1</accession>
    <name>A0A4Q9LXR1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0414p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000414">
        <property type="protein sequence ID" value="TBU13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0414p0010"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="53"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="32770" checksum="BF0406CB28B3FF47" modified="2019-07-31" version="1">MSIFLGLLCFVFSNEVFRLMELLSFFAPGVDENGKSHRYAFYDDHIIVTYSSDKTYLRLCYLNGPSKGGMLSKNVIPFDNFRVDIRFSLIKPEEKSYGNGIAFWVTKENEFISGDCYGRNEKFSGCLVVLDTSPVSKTAGVSSPYIGVACGNELNYDVSSKGANIIKSPVQLKPTIFNSKCILRIENIDNNLKVSLSYKDNGFQEIYKISNSGITKDCKFGISAMNSFNNFEYRIIGIRTYSAEKIAKTHTTGEQHEPKKGSRYVWLIFAVVIVAIGYYLYRKGERLNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP8</accession>
    <name>A0A4Q9LYP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0410p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000410">
        <property type="protein sequence ID" value="TBU13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0410p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020373486" evidence="1">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="432" mass="52050" checksum="672F2C3174189A22" modified="2019-07-31" version="1">MLLSQLMNLYIFLILWRTIFSTIKPIEKTNYNVDKVYEILCKEVYRQYRKRVLEMDYVFEYDFLILEMIPMFVDECDLEVFSYLYQKQLESTFLHFIYLIKDQDSFFELKTYFLFKIIENHVHFNTKDKYCIKIDSILYFCKKQLNFGIFENFKKNRYVFTFLNRLLNYLNCIIKLMCKKHNIIIFKSISESQWCESFTLKNFLLSLLVQNETTIDCDYSILITKNKKNKISVPFNIANMLKNTFTSMFYLDRSFSSLEKFENGALPPIFIHSMNHTLKIYDRNIVSLNILTRLNLFEINVSQFNSKAEKESKTKNTKYFCTYKFLNLDISIYLIKPKIRKNKNKDTKSDKNILKIAVKSLFEPSSLEFNFYYNEKNSSITEIICIGTCENFQSNYSIKEKLNFILRYLNSMQTLYPENYIFSPIEKRTHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR5</accession>
    <name>A0A4Q9LYR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0431p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000431">
        <property type="protein sequence ID" value="TBU13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0431p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="563" mass="65979" checksum="456AD99FC147F7BC" modified="2019-07-31" version="1">MPNIESDETFSMQAVGNNPCLDSDQRTISECSHFQPAYYRSKNTENFLSFSQRTSNKERDKMSRDSINLSKMGNNAKEQLVEEEPYLDSEKFVIPEFSSLTSDVVKEELLVLELYSTPKDNTVAYIQNGTEIDVDRTKSNLKRGNDANSYDIRWQRNDSFISDDFSEHSNKRPRVNKKARSSDIGNRDASISSDSHNNPCLYLPECEPICCENNHEDTKIASYINQFKIRIYADEMIVCARKCSTYFYYLNLVPELYLELNNLFKIKKPNEFPSNNQNYETDLRYNNYLIKIKNEIKKYDSVDIGTNEMIEEIVIFANYLVEFEKTISSDFILKENNYILYVYFLLSVISKQFDNFDKNFSLEYKRCVITNKICENNCKSKYLQKLFVQKLFFRLLLGMKAGRTKASFYNVYLSLELNDKGYLRICVSVVLNLKCELDINQLDRFINLSLEIFTLKSTSKKIFTDEIKLFIYQADIHLIVKKNLMIIKEISDKKRIYKNCRFIDQSLIYLKNRIKSEPINGLINDDIVLSEICLVYILSESYINNNFEGRKKPPKMGRSILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT2</accession>
    <name>A0A4Q9LYT2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0592p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000592">
        <property type="protein sequence ID" value="TBU12895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0592p0020"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="11">
        <location>
            <begin position="597"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="657" mass="75923" checksum="BFDDAEC469EDD821" modified="2019-07-31" version="1">MENIFLAAGSTRRNHVTCYYNDTLIFAAKNNIILLKNKKEVIITNQSLITVLNCIDDMIIAGDDQGNINVYDFYTHKQLKTFKLDDSVQLISKIPHKDIYICGSFNKLYFIESKAVKYFEIKNELITCGDIFYLNNEYLQVTGTYSGNIIVFQINNSNFTPKLTFNAHKDSITTIKCHYIKEDIYFLTASQDKFIKIWKINRNENGDKLFIMDHTSYSITLVKTLSGHRDWIYNCIWTEEDGIYSVSQDDSCILWKYKNNDWSNDIRLGGIASKNQGFFDIVKSKDSIFCLSYFGGFYKYTSNSLVYCTSGHQDEITSLDWYNNYLLSTSLDSTARIFNINSQKEIARAQIHGYPLKVARFLKKDTFSFISAGQETQLRVFQATQIFIKNHEFDFSTIDPQSDLQIYKPKSIHSELSLTNEISNDYHTSDLQINEYTLTHSTLFHEISKIFVHYFEIEDIAVSPYFIASVNKSSSLDFSGIFITSHSFQKLNYIKVHRLGIQRIRFSSQFNYLMAVSRDKTASIYKVTTTYPYISLLQTFTDHKRCIWDCSFSPTENLVATVSRDKKVFIYQIPTLKLIFENTFTSEATTISFGNKILAIGTENGEIFLYTFYNQIVFHSKIQAHTNRINVLEFDQHGTLLATGGKDSLIQVFQISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU4</accession>
    <name>A0A4Q9LYU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0290p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000290">
        <property type="protein sequence ID" value="TBU17011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0290p0010"/>
    <dbReference type="OrthoDB" id="7789470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="543" mass="63668" checksum="052A9BE7974C54F4" modified="2019-07-31" version="1" fragment="single">MEKNKDDICCKFCRNKLVYRKATNGCRIYLFSIFNIFQIYLLHFILLNKCACLQIEISFSNEAENFEVNCNEAVDNLNNLCENCASDRIATERIPESNVQDFSDNTPALAALLDRNDHIVDPGTIPIITGISSKKRKQDLFLPESDEISNTQYSSLIQRQTNEKIVSQGEELQPLDLRTNKKQKTYDLIEFENNEWILKTPTSIIFEYSDKFCIQSKYFNKYKHTELNYVRYNITDLTKSKIDIATFEIFLFVLRFGCHKKCIDIKIYDFITFLRLFCDLLCHAESDVICNLYKSLLPSFFIYKNDISVNIHIETPENIFLVQKSLFLPFLNTFFSNVEVKFDQNTKELSLLKRESSLHLYSFDERNIDEIIIRTTPEVINILETESNINLKLFFWLISLFKIIGIKISNDNIYYSESKERDRICKYENSALAFPSPNLKLLYSHILESIISHNNNEIKFLELERVNISEGFLNFIKILCKIESLILYTCKLPAYSNFLCHLNFCFPKLKTLKVNTLILTAAFFKSLRNLKIEYLDLSWSTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU8</accession>
    <name>A0A4Q9LYU8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0528p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000528">
        <property type="protein sequence ID" value="TBU13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0528p0020"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="28658" checksum="87FA35EA29E36C63" modified="2019-07-31" version="1">MFLVFYQMIKEKEVEKSFQFIKDNLNCCFSLEKLNIKEIKGIFILGGDGTVLKILQKLNMSEIPDIYAVNHGFKGFLCPIKPSEVEKMVLKINKNENEIKFLKRKRLFLKDGGYFLNDVIITRKACGKLNKFKIFIDNKFICEIRCDSVIIATPTGSSGYNLSAGGSIVSNDCNVMIITFVCPPDTKIKSIVVPITSKITVKLQKFPDAESVCIIDGGNEIVGKEEYEINNDNSFVRFAYLDENQSVLTELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ49</accession>
    <name>A0A4Q9LZ49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0391p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000391">
        <property type="protein sequence ID" value="TBU13567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0391p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="28373" checksum="1E9EEC850858B4A7" modified="2019-07-31" version="1" fragment="single">MLAEKNKNINKLKAANDADEVNKSESNIQKCELHPPANSQPSFSYTTTTHPPPNKTCSSIQNSGLDTLKSPNTPLPNSVEVSLFSKDNRLMALRTIFDSVTADPKEWPQVVFFCSTDKLHRYYNEKFGCTETLEVLKKLAQSEMLKEVKSEENGERRSIATCLADICTLTDTTTYINLRDKFLSKIKEISENEIGKVVVRTRKLPSELVDSKFLDLINIVVGEYAKAHIPGSIRKLRISCKLCRYAMTRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE9</accession>
    <name>A0A4Q9LZE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0365p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000365">
        <property type="protein sequence ID" value="TBU13677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0365p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="346" mass="40882" checksum="6DFBE7B402228F53" modified="2019-07-31" version="1" fragment="single">NFIQKELISRSSEANENEEINCNKKRIFSEIKDNQSDYTFQHGNISKSVESLSSDPYSRKKFKKKNVCKCNISEITKINIDIETFEIFLFVLHFGYNIKCLDLKKEKFMDFLVIFSDLICYAESNVIFGLYKHLISLLVSYKNDILNKFPNVIEKHFFSVNTSPFLPFLSTFFDDINVEFDENINEVLFLKNTNENEIYYFHKTIINDIKIRTTPKALILIENQPDFDAELFFWVIFSYKISGLKISHDNMYYSECYEKDKDYIENNLPRESLTPKLFLFSSKVLKAIIIMKKTQIRYLELERVTLTPYDICIMQNLNNLESLILVNCILPSKNQFFAKLWAFPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI6</accession>
    <name>A0A4Q9LZI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0212p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000212">
        <property type="protein sequence ID" value="TBU19446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0212p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020798730" evidence="1">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="580" mass="69292" checksum="C524017603F35537" modified="2019-07-31" version="1">MILQFRVYFVVLTIFYQKCYDSNITESIDTTDLEQPTCSYYLDNNNKKAGMGKKGLSENDKVFGSSCILGVRKKSKIINHKNTRNIQSRNGFSRFKPKVFLTRGLEDSQPLDFHSIYLLSVYELRFDCQLNILKERFGEKIPWKTFNFRYLEIIEDSSLARVNSNILNIRKCYVSIHKIYRFSLLTQRNSLSFVDEDIGIIAVQILYSNKSFEKNLFYSIDLEINQDIVKLYCEENYLEEFRCKIDYFIQIELNLMKNTENIDNISSDMNCIYSNDFIKYWKALILELLTNKDKYIYIILPEFLSFEIKILENLNNIRLADGNYFLSILYLKFLLVDPKINEIKLRYNRLDSIKKQNESSVEVYEWFLNEKILLKKKFLKILEIFVFSVNTNLLYSVFYLAEKTIYFNLISKKFDSTYLTFFHSLNIFNTVIFQMDEITIKNAFVKFDLVLQNIMKHEKSTGMRFFDTNSGIFNPTFDQIIILNLIRVLRYILNIKIDDDHFEMYEEYDLILYELNAIHNTIVKGHKKVYLMTRKTAVKEVFHTYEISNFLLCLKYRIFKYKFGIEGFLNTIQHFNSYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ3</accession>
    <name>A0A4Q9LZJ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0495p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000495">
        <property type="protein sequence ID" value="TBU13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0495p0010"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="91"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="719"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="950" mass="106432" checksum="557B8E67B6764036" modified="2019-07-31" version="1">MSECTTTMINDLLPSYLLTPFPYNTFYLIITSGAKGSIVNLSQISVLLGQQELEGKRVSNMISNKTLPCYSIKDMIEIESKGFIFDRFLTGIKENMYFFHCMAGREGLIDTAVKTSKSGYLQRCLVKHMEGVKVEYDMSVRQGKKVIQFIYGDDGIDCSKWSLIREYDMYKENCGYGDSNRVRDSTRDRDWDRDSNTISNSNPFSIYGRISTPIFNNNNTTPISTPISNNISTPLSNNISTPISMSSVINYFPPQLFIPSLKYFEDLKVYCDKNIGYNGDSNRDISNRDIGNRDIGNRDIGNRDIGNRDIGNRDSISNRDIGNNNDLRNNEIPYNNEIPYNNSLRNYNDIPFNNHNNTNTNTTNTNTSNTNHNTNHNTNNNTTNTNILVSYILKKYISSLVVAGESVGVLAAQSIGEPSTQMTLNTFHLAGVGSKNVTLGIPRLREILMVASKKIQTPVISVRYYNISNVLLERVMSCVVLKECVDRISVSEIGNRISVNLEINGRYFMGGISRGGECGGCIGDSKEYDSGSSIGGGKEYDNNTNNIDNTNNIDNTNNIDNTNNIDNITDTNTLNTNNTINTNTINDNNTNSYVVTSSSIYKVVKGKYLKMVDKSIKNLYGVLNNYKGSCIKVRGGGSSEGEGEGEGEGNSGSSEGSSEESKEIDEEYIGKVEDSSEEDEGEDEGEGEGDRRKDKKKDKRKDRRKDKKKDKKKDKKKKNNHTKNKNNHPNTNTKNNIRFYCISNLETSFVGRIINLSFDLNFDKNIILFPILEDTLNKVIVRCVEGLRNPICDKNILNINGNDLYSLCSVVNINKNIKNYKNFLDIEKSYCNDVYGMYKILGVEGCRSVLVREIESVFDVYGIGVDNRHLGLISDYLLVDGVYSSFSRFGMEKSESILLKMSFESCYSVLRDASHRELGDCLEGPSGCLTAGLPVRNGTGCFELLYDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV3</accession>
    <name>A0A4Q9LZV3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 4-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0421p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000421">
        <property type="protein sequence ID" value="TBU13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LZV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0421p0010"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="1552"/>
            <end position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1848" mass="215517" checksum="26C7FF5F674AF264" modified="2019-07-31" version="1">MQFDEYKEYKSTLNNQKISINFRFNKKVTTDDLKSALNHFTYEDPFFIFLLLKNTLYTTDTQMLQTTDKNLYQIFLDSFTLLLNTHLYEIIINDILTLSFTTPLCYSLKSALLEIFISNYSFLHIEEFTSLIETLSTTIKSSTFNEIINYQNDEPLMNAMLDTFLLTLSLIAKYLETRKILDLSITNHHLYSFSFSLYNEMLMLLNTSNFMEKDIVFIFINSFIINTFTEGTCINQIKDILLSHNLMIGEDSMIEIQYRIIYTMGCLSPKDFLYVLDLIFTTDCIIFMAKRKAHSLINRITNLFIITEQENNYKTYKGCKKNHNILTDEEKEAKDYETIKEFKEKLNLKLKQEISKEIKNDANYEENEKTKEEIKEEIFQKNEKQFEIPLCIKSKLKNKNFTKKCIKTENIKEELLLCISSQNLFTIYRKAFFYISSLTKYKNLYSQNFLYFISLKPLPFHFPEINNFFLKLTTQTSPEYYANFLLKNEFSFPLYTFLNSLPPEYPLNFYYHVFKNLKKDNLPVTDTPFNNTLYIPTKTDFHILDFLNFFLEKRDKILIQLLNTLPYIPPYKPFYPVIYDVWIFILKHNFLKNMTFFFLKTPALVKMADSLQHPSSKLQIKIPFILKKTPKPPHLTFLTILYFSEKNKISNFNYTGVIEYITDDKTLRFLKEEVEELIEQIHLEEGVIERKFNFIDKEGLEALEREKGCYTVIKGNNTTTYNNTPINKSNITTTYNNTPINNPNITNTSDNTPITTTLINNTPVITFAFNNPLPMPFNLSYAYTLLSLGTNTSSYKTTLIISLKILKILLCKDNTLLYNIKLHIYFSEIFKTLKARNQFKDTEDVFISYLSFYKTILSEISGNSPIFYNYIVLFIADITLFGKDYLTLGFTSFKDLYSYVEITMKKIEDFSNEVCELRGVKDSRYVLEGVKDRFCNLKGVKDSRDVLEGVKDMVWELEGVNKYKDIQQGVNNYKDEQQRVNNYKDIQLGVNNYKDIQQGVNNITNQQQGVNNITNQQQGVNNLTNQQQGVNYSIDVTSDIFFLIDVVYLNLYNSNTLLSVIQLLKTLLATTFNYKTLYVLVRICNTLYLPKSIVLPYLKRVLRVDVDFKIDPVIFRKLSIETEGFFKFFFDNICVIIGESITNNNTTYNNTSSLWYNRYSGYKGVNTSNRIIESITLDNWYSYYKRYPLNINLPMTNNKTPLITNIDFEASLKHTVNNNTLDDKDLTLIYNMYRRKGVISFIRNNSKIFNYLNYSIFVDNSMSVMDCITVIYRSLNREHIKIALEVLKTKQNIRFYIPQLIQVLRREEVRCDVFILLIHLSNNNILCHELLLNLKCNISEENGNKKNLRGDHTNKSNVFKKCMDDLILGIGEKEVLLYEKQVKFYKNLNSISFNARNEENKKEFINKELEKIEIGGVNEEVWDIKGVSYKDMLEGVNDRGSKEEGVNERGSKQQGVTYKDILEGVNDIVTKEEGVSYKDMLEGVNDIGTKEEGVSYKDSSISGVNKEDILECVNKGDTKQRGVNNVSDIQQGVSIEGLYYCFGTEEIIDIVKGSGRVLQSHAKVPYMITLKCINKGGVSNDGVIKTPCSYIYKRLIVKAGDDCRQDMLALQLIQIFKDIFKKNNLDIFLYPYRVLCTDSECGLIEVVENAITRDQIGREKINSLVDYFELKFGFKEGERYSKALYNFVSSLVGYSLVVYFLNIKDRHNGNILIDDDGFMIHIDFGFMFETSPGNLSIELPLKLTAEIFMLMGGYDGVAFKFYREMMVKGFVALRRSSKEIMYAVDCFKESGLDCYRKGAVDNFYSRFMFNVGDNEIKENVEKMINGSCKKFRTWIYDKYQEVTNNIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L7</accession>
    <name>A0A4Q9M0L7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0218p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000218">
        <property type="protein sequence ID" value="TBU19123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0L7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0218p0010"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="38891" checksum="9261A6B4148A6DC0" modified="2019-07-31" version="1">MDSESFKWSVLLQNIDNMSIKTLQYTPMGYGSIPENRKIQEYIKNGAINLDKPCNPSSHEVVTWIKNILNVEKTGHSGTLDPSVSGCLIVCIDKATRLVKSQQSDGKEYVCVIQFHTETTEKEFKKVLKKLTGNLFQRPPLMCAVKRNLRLRNIYKTEFIEFDKENKKGLFKVSCEAGTYIRTFCVHVGLLLGCGAHMLELRRTKSGLLNESTCVTLHDLKDAMHVFKKTGEEKYIRKVIFPLENLLIKYPRILVKDSCVGSICHGAQLTLPGVLRFDNNIEIGTDVVIITTKGEAVALAISTMSSPEIHIANHGVVCKTKRVIMDKSTYPSLWGNKDDVFMLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N7</accession>
    <name>A0A4Q9M0N7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0126p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000126">
        <property type="protein sequence ID" value="TBU20145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0126p0060"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9330" checksum="16335B8D945F9FBF" modified="2019-07-31" version="1">MLDCLEKTKEILTRKALYNETETRNSHIKTSSRFLNIRNIRPRDEEMLWGAKDICLYYNKPGRILDHLATRCEKMLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T9</accession>
    <name>A0A4Q9M0T9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0323p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="6909" checksum="288B6D83BFAFBC15" modified="2019-07-31" version="1">MTTEIEKDEDILDKLAILDDESKDLLRYVEEVNISFNNCYEAVDGLLTASVRIEKTFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B5</accession>
    <name>A0A4Q9M1B5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0062p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000062">
        <property type="protein sequence ID" value="TBU20490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0062p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="8279" checksum="E60F569CF1B5DA68" modified="2019-07-31" version="1">MIDVLKNKFLRMHLLSICTWVCIYYYNDTIPDTNLQKKIKKGAYFIGILIDHKLYTNKISDQLINNAENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E1</accession>
    <name>A0A4Q9M1E1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0068p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="554" mass="65532" checksum="77987C46BB30FDB8" modified="2019-07-31" version="1">MVKQEIKKILGYRSISGTDYFLVSWSDMSQTWEPSNNISAIKEINLFIYKLKEYQRELLAEVVKEKRKAEERKILLELQSMKRVENVSFNITSFIDKPKSDIKKKENLERQISTKNSNMRKKEPPKSSFVKNQVQSIPKFSNSRRYFEIEKPIVLEKKIIETPKPFLAPKDSFIMSYENNYIANFHIKNGSSNLIKKPPTKMKICFYIEIADIYSLLFSSLQNKKLQKYDYFNLLLHNSDPKFSEFNEEISKNKKAFVDIETDINVAYIFFYHEKAFKKYDIHGFYNLLVFEKKYFIETKMFKNMKKIQNDEFLIWNKNSAIFESVVEDLIIFNLYEYNLSPIFKFSIFSNDSSEVMQYFSSFLKRRGCEQISSLEKSTSIIFINKDYISYVNTIPNLIYHKKNRSRFFVFDTSKCDLNFSPIYEIFKRGCVITITRSLLFNVNVSGLLDVLNYSNEHPDKCLLRVPGQLVSDFKLKLNESSTSLSFSAYSNIFEIIKNSVENISCSSIEEYLTCLELKYQTQRRFFFILNETNTGYFIVTPTAFYDNYIKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E2</accession>
    <name>A0A4Q9M1E2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0051p0040</name>
        <name evidence="2" type="ORF">CWI38_0063p0050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000063">
        <property type="protein sequence ID" value="TBU20489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0063p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="16927" checksum="6D0D3389CC63872A" modified="2019-07-31" version="1">MCLIAISKESMSAKEQEDFLKMQDELLKGFQELEEKARKDGENRGCIRSEETTERASRKKSSSNKKAQVKKSKRGSRNSSNSAASEYSGAVGTTENGSSKQTSSEISSSRASTGNPTFEPENLTDEEFPKRFNKNHRKIEEYLEESDCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1F5</accession>
    <name>A0A4Q9M1F5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0305p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000305">
        <property type="protein sequence ID" value="TBU15841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1F5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0305p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="344" mass="41035" checksum="D29984757C72AED0" modified="2019-07-31" version="1">MKIEELKEIHSLLQKKKTDIEFFIEESITKNLKYIKIGLQDYESLNFNNKWKGIGIYLLCIHKILTISDNIYNIFASNFNKNIFCVSNRENIYNENKKDINEYLKALFCFHNLLLEIIEKFKNKIEKNKGKFNENELFKNLVQYLSSKGKNLFQKKSSLKKDDIFGTVDSYINILNESIILKMADTVVAEYSFEKNQYKYNSFTLSFLRNDICRTFEIKDMNFFIFKKKLNLILKQASSRFNFPLRDLEILNSYGFMKKNSDLEIINIGDILDDRFKDHAKYRIDRFTSLLYTTDIQDINKALMVSYICNICPCLIDLINIDYFDSKYEVYYVKWIHNYKNTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H7</accession>
    <name>A0A4Q9M1H7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0057p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0090"/>
    <dbReference type="OrthoDB" id="10417643at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="579" mass="66799" checksum="F8D56801A09F9582" modified="2019-07-31" version="1">MDGKELIIILVRVVLESLAYYNAKIMYTCSSIQHISPILTMYLTHSSGCLIILKDMVKYRLKYFEKMEKDTGVGRRTFMVRVVVLSIFYNLCHIPKFYSMKCLRDAYIVSIYGSSVLFSHVFSLIFNIEKISRKGVFSMVLCLAGLVVIVLDDVSCRKHYVWAIICFLAAVFSGLYTVLLKICIEIPEKVKKIKNNNLRQKEIDFYETSNNELQKELEIGNDYEIKEKMENTGTKDFAPNSHENKECNLEIGNKKDLRTRDFIVNSKKNKDINLESGKNIKDLRMKTCIISSLDNSEKNLEKTNNGCDVTEEHFLISNDILESSVEQNKKDLKMTEVKYMISSEANPEIKKNIKHGISKDSKIDFKTNLENNSYKFKPISLEIQDFLPIESNITNELHCLNEKVNENHIDTKLHISNQIYIPPEIPLNTNIVTNKSNKENKIVKPNSNIINIEKENLNRKLIYMKYYMGLTGLFTLLFYWPFLLLVNLKSIDEISIPTQGRQIFHIFAANILSLCQNTIYLLLISYKSPVFAQVSGIFFQPTVVIIQLFRSIDIIHCTEILGCFSIFFSFCLLGKSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1P7</accession>
    <name>A0A4Q9M1P7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0315p0020</name>
        <name evidence="9" type="ORF">CWI37_0331p0030</name>
        <name evidence="11" type="ORF">CWI38_0279p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000331">
        <property type="protein sequence ID" value="TBU03227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000315">
        <property type="protein sequence ID" value="TBU03316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000279">
        <property type="protein sequence ID" value="TBU17626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1P7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1P7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0315p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0331p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0279p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU03227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="265" mass="30005" checksum="5D7A53B603A7BD86" modified="2019-07-31" version="1">MNVEWKNLNIELINKNKSIDKKYIKLVQNAYGEAKVGELCAIMGPSGSGKTTLLKALAGRIPDGSRTSGVITCNKSERKQSDWINNVAFVDQDDCCFDDLTIRQTITYSAKFRLKNTNIKVKDKVDAILTSLDLTKVADNRTKSISGGERKRTMIGVELVTDPKIILLDEPTSGLDSSYALDIIKLFKKIAEKNNVTIIFTIHQPSYEMFLLFDRLILLFNGNTVYNNTALEFKSKAESFGFIKREFCSEPEFAIEILKFREEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U6</accession>
    <name>A0A4Q9M1U6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0254p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000254">
        <property type="protein sequence ID" value="TBU18109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0254p0040"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31424" checksum="98A2DB096CA49BB4" modified="2019-07-31" version="1">MNPFFCYIQDRNVFLGAKSVCQHCNTSRKIENHLATRCEKMLGHDYTRRHNEVVRGLHLLLLNRYKFNHSVQAILHNEYTEIRVDTRIKTDVKIRNNRPEIFILDKKKNKITHIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIILYVMTWDGIVTKYHKSHLKRLKIHMNVEAYKTVETISFDRRRGLDSGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREEDGGTTLEEPTNNINKDSDLEEETTVVKEVEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M202</accession>
    <name>A0A4Q9M202_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0240p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000240">
        <property type="protein sequence ID" value="TBU18500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M202"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0240p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="11601" checksum="509EE237002AD991" modified="2019-07-31" version="1" fragment="single">MEISKKEIIIICCILGILSTMAITYKLIQNKKDSNKKNDGKKPENQKLKAKEKESPNITKNIPKISHNVSPHNVSPPPLPSDIPTPPPLPSDIPSPPPLPSEIPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M220</accession>
    <name>A0A4Q9M220_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0022p0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0100"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="773" mass="88768" checksum="B9CD8B82AB8BF104" modified="2019-07-31" version="1">MHNPLLSESFNPIKYINDTFKTSTEYDLNDTLVSLHKSINITKLKSKQLVASHFSQFVQCKSVIDNVYSDIKLKHITLHHYSTDNMLNLLSSLPSKHIDLGLQLHTDHHTPTTHNTPASQNILPEFVLSKLSKALENKDYKTFISLYPQHIQHPIKIVFLDSLQSDIHHTKSLSTLLKLFKYYFTIEPTTFPYQTISNTLLVNFKECINSIGKGYTNITYNRDSNTTSNINNRDSNTTSNINNRDSNTTSNVNNRDSNSNTNITSNTSVSTSTIYTTTHFTNTDIFKVTLYLKNIIKKVSATNKEPDFTNTVTILVNEYINFIKYIIYKEIGNEYNNVTYGYETIDSTILQNQNSIDPTYFNKDGLTNNNHTNSYITNISHNNHTNSYINNISHNNLNNISHNNPNNISHNNPNNISQNNPNNISHNNPNNISHNNPNNISQNNPNNISHNNPNNISHNNLPVTSTSLLKVLTFTNKILNSYKYDTMDIEDIKREMLYKEWYGSIYNIPIFINMYGSSMFKECVIQYIKRVIIKYNEYLCGRLSLSKSDGVEGGIGKNEGYSKDNKDNKDNKDNKGYSKDNNKNNNKEYNKNNNNDNSSDIKDNRNNKDNRNSKDNKDIYNKDTNKDTNNTNINNNNTNNNTNNISNNISNNIPFYNALLVVYNTYELLNNKNIKNIGIKPSLYNTLQQELINLQVSLIIRIIENIKISSNIYMSSKSSNYKGVICSKILKVIYSVNFVDNSVIEIVKNKYKDVNFVEISVIEIVKNKYKEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M255</accession>
    <name>A0A4Q9M255_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0237p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000237">
        <property type="protein sequence ID" value="TBU18515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M255"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0237p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15468" checksum="2EB3AE1D87A29F7C" modified="2019-07-31" version="1">MTENNLNISLDEESGRLFYPLYYCIYDNSLSSSGDLYLRVEDVLTLLSGFKHFESQDINLCLHNIMDHISEKSFIQNLEKCLINLFDVYKNCYSLKSSLDNRLDNRLYNMVALPLKKFLEKLITKIEEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H4</accession>
    <name>A0A4Q9M2H4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0214p0090</name>
        <name evidence="1" type="ORF">CWI38_0220p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0070"/>
    <dbReference type="OrthoDB" id="2191887at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="17590" checksum="9FA003B0007D9A7F" modified="2019-07-31" version="1">MYEEDEEILLLKNIFKNNLIIQNTTIHCILPKGVISLQKINKNITIKYIDGSISILKELKKYLEENTCEYILYPLIFKYSLLSEKSKFVTEKTQIDLEIQNVQRISEEEFLQWKCHKVYVRPKYEKMTGKEFFINLRNSKTEWKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L0</accession>
    <name>A0A4Q9M2L0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0003p0090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2L0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0090"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU21014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="717" mass="83573" checksum="83A13019CD045A25" modified="2019-07-31" version="1">MKFEDFLEKNIHPEYKYYYIDYTGLRNRLKKEFNEEEENAFVGELEEEMNRVFNFINLKHDEFSKRISLINRDIKGTEIYSNSNVSSKSRNRTESSLHGIGCNISTGNGSSLVSKSKDSIRNSKCSVDSNTDMNSVSRNSISRTSGSINISSRSSVNTDCNSKESAPRINDSKSNESVNVTIKGEISKIQDEMKIFADYITINIVGFKKILKKHDKFTNYNILPFYMPKLKSKIRSMKNLDALLYKVSKTILSHSYVNLEKNSLSTSSFVRNTSKYWVHRDNILSLKCFVLRYLPIYVFSNENNEESPFASWNEKTHDRCISSVYFDNRWFSLYEGRLRKLPGAEAIRIRWYTSKIGKLVFIERKRHEDGWTGVQSKKERFKMPEKYVDDYINGHDVWKHCKSYNKDNKREALQLYKEIQEKIVKEKLRPVVRTFYKRTAFQLPNSAQVRISLDTELCMIRECTENDLKNDVRPLVWRRKDVECEYPFTKLKKEDIVRFPYAILEIKLQSVDETKPDWVNELISSSLVEHVHKFSKFLHGAAVLFQNISDIPYWLPQMDVNICRKEFLVTPMNKEIVIDIPENDEIPLISDSSKAGLMTVDTRNKRIALPVRIEPKVFFANERTFLSWLHFSIFIGGIGTALMGLGDSKAVYSGIAFICVSVLFAIYALYLYFWRASMIRLRDPGPYDDLYGPFILVVVFLIAMVLSIFFKFPLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2V1</accession>
    <name>A0A4Q9M2V1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0181p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000181">
        <property type="protein sequence ID" value="TBU19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2V1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2V1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0181p0040"/>
    <dbReference type="OrthoDB" id="2191694at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="714" mass="84601" checksum="D3029BFDB9B2E46D" modified="2019-07-31" version="1">MVNIKKDIFNDINKYKEAINVEIKEISMKDESTIRDYYMNILESEDIYYIFYVLKISFLIKVKFVNRNILEKLNELLQMVSMTRNVIEIEYKKICLEFIKNHIINNDNIDIIITVLGHLDLNDHEIMYFRKFFGYSKIYNYYKNVNKMIFEKYFTTEELIVLIRLLDNHELCFLHLLPAITRINEYVTDSVVEKNIVSCCIILNSVILGSPKSFKDKDDYVISTISFLTNIFYDSKNFTFINLEDAKIILLTINNLTNSIKNNSRISNLSFGIYNESLEIYEQMTKGHTTVLEEYIVIGCLIKLIGIFYMVSYDIGCRMHDTDYLFNLIQDSDIEKPQYINDTEWKNIYEFFLSHKYETLDLIYPSTLEVIFKSDVLYLHLIKCSTPYDALLPLKNMLREVDWSLLIALACSDKRSEYISFLFNPVFFKNNATEHYEYIHIFIEAAFKNNDYDILLIVTHILVENHKDLIKKEDFLSLYVNLFLSNFSHSVNFTISYRREKLLNFFCENVTDKNTNNLILVILDFLTKHKITTPTKYVFTLIFLYSSRTNDISNETVIKLKDYTFKCIQFHSTILTSEFDKYNEELYFNIISNPHIKLYIVMLSLYMVNFNLKIDFTDEDLISCDHILYIKLIISLICYKRGQFDESYLEDIRKVLLKFIINSRNSHVSTLGMLIKESDKSILIENTEKADILAFYDNILEKLQTCLKKEKCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M377</accession>
    <name>A0A4Q9M377_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sir2-like telomeric silencing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0148p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M377"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M377"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0040"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="802"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="923" mass="108065" checksum="C29B7EFFB5427AD1" modified="2019-07-31" version="1">MQFIDCKWVRENYKIFNNKRVVIITGAGISVNSGIPDFRSKNGIFNEIKQSLKVQGSDLFTYRYSIQPETRPKYLKFIYKLKELTDESKPTETHNFFVKYKNFSKKMHIYTQNIDGLEEKAGLIFSKESKNTEIIYLHGNMKFLKCSYCGYQIPFTKTENLKFKISEEIECINCLEREKKRKENHQRSTPIGVMNTTIIHYYQSHPESSFISEMVSKDTDLNLFIVMGTSLQIYGIKKIVKYFGFSNRNNKGVSIYVNKEEPRSEFKDVFDFQWKGDCDEFCKEILNLLETKPIETNESHSSILKIKETTKNEKNIRKSLDKLTISQNKSLEKSIDQPKVQKGIKKEIKEETKKEICKEIKKDVYKEMKKGICKEIENKKDIFEDNKNDIKKEIEKEIHKGIKNEIQEEIIKETQEENKKDVYKETQEDIIKETQEDIKKEIIKEIQEDIKKEIQEVIIKEIQEDIIKDVYKETQEDIIKETQEDIKKDIIKEIQEDIKKDVYKEIIISSESKVKTCKYLSKIQELSTPKKSFTIKIKKKPEIKNKNFIKNKEFSINPNNFHEKQIQNKISETNFNTKNFENETKVSNFVKNKNKNNTKQTMKNKSEIIFTNEYSTITKVHSDSSEEKLFIFDKCESSKIEGMDCDDLKMGEQSDEKNEENGNTEKKKTQENLKISIDDVKNVVRNIADLSSNAYIMESKPETVNKVDYVDSNTESSNCFMSKYSNTENLNCSEADTNVIREYTVEETDSVDQESEEEKQTEYFFSPEIIIDENNSPVEEDQCYGELIDEKEFHEVNEPEIKISESQIESSINHTGDEKTEDEQEQDVAIKTRPKRKSSKRFSTSYYRTTKKTGNKKKKSIPASKQKINESEVISEPVDNKKPLTTENSEDYKREGSFVVGEPTKEKGIKAFTKVVSKETNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M386</accession>
    <name>A0A4Q9M386_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0122p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000122">
        <property type="protein sequence ID" value="TBU20162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M386"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0122p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="311" mass="37144" checksum="F39E9978D90AA69A" modified="2019-07-31" version="1">MKYLFNILLILKCIKLSNFEREESIDQLVKEISEMIVKEENRVILENLDHKFSITLLVFKGINASFCVPIFSCDREELKVCNKENNSAVSLKKHKFNNLFCKKIIERLIRSNIFIFPETEENESIEIIEVQNELKSKNVDIPQFMMFLIYNSQVKDLADKEYEIINLLSDISEDFVEKIFHKFVYLCFPSLNYKFLEENKKVDEVKNLILSFISKKFIEIHNNSKNIFTTIKYIFKNFYFKFGFFICKIMKNSKDFFVTQKREKLYEYLLNNKENMCDLLKKVLGGYISFDEDKNLGIYEEFDNILSNFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M394</accession>
    <name>A0A4Q9M394_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0037p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000037">
        <property type="protein sequence ID" value="TBU20667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M394"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M394"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0037p0010"/>
    <dbReference type="OrthoDB" id="2199244at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="12858" checksum="26114E06FC29ACC8" modified="2019-07-31" version="1" fragment="single">MLNSFSGKNTNENKYDFHVGETPEYIECENDNVLKCLVETSGSHDENLSLSTIPTLRKQKVSINDRERIIEKTLEGYSMSAIASMYRINYQTVNSIVRRYLKTGLVFVDKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3I9</accession>
    <name>A0A4Q9M3I9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0134p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3I9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="165" mass="19484" checksum="02BFC605D947733C" modified="2019-07-31" version="1">MLFKRYKKRLQNKKEEPKLKKIKNPIQTTNFTKIQRIQHLLSSNSNDMKNIAFNSILLLPEDYFKTYLVILTPQILMNTVVLTQSRSNLSNFLVFKKLVTKIVNSSLFPSVHEKFSNYIKILPFQQSKVLEDIYQSRKNYSLKISPINFNARIFLKNKNLLKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Q8</accession>
    <name>A0A4Q9M3Q8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0108p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000108">
        <property type="protein sequence ID" value="TBU20231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Q8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3Q8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0108p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="423" mass="49755" checksum="B603B66B9E9106B4" modified="2019-07-31" version="1">MTNLSCLGENCTIDFPKEIVSCNLEQKYTYIFSEKIAKRTYSEVLMYICTNTNQKVAIKVKFSANTKDSKENIALKSMNHPNIVKYIDFLVIGEYEYIIMEYVPCTLENYLEKQVYGLKDIKIILKQILDAMKYLEYIQVIHINIKPNNILLDENLNVKLIDFAICCTIQDKSLNFSIDSDLDTALKEFPQIAPEILSGDFFDNSADIYSFGYVCLFIQERFIENVLCDEKNKKSNDLLSNLIYNSYCSFRTNRSSISALIFHPFFDELYESLECFCNFDNIKPNMGDIEIWPYDGKIHIKKDNIEFTLYCSCHDKLDLDRNLEYIRIQKTYLSTFSFYNTTNININKFSVKIRKILLHIKFLYKEDLLHIIKAFEIIKKSRSRLSDKQMRSEYNQSVVEENRVRSENKCSYWLRGLIRSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3T6</accession>
    <name>A0A4Q9M3T6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0035p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1530" mass="180269" checksum="E47848C1FEDD3B87" modified="2019-07-31" version="1">MTNHCEKKLAQSEMGKEVKSEENGERRRIATFFANTCTLSDTTVYINLRDKLFSKTKEISEKEIEKVEIRTRKNPNKLVDSKVLDLINRVVCEYAKAHVPNSITETAYIMQAAQVCYDEATRKEKPRSALPFGNKKLYEIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVKSEHVVSSDEIVSFWSTMWNKNTDTVTYENYLIPFVSDNHPTMFLLLDEFVNIINWLPNWKAAGIDGIYLEEEALLQNNTCIFNLYKLTTKCVTKVLAENKLVTVRDRVILHGDSWILSAMTGEANEFKMEIATNYTCCEDTGSLLEGVAQTSKDLKDFANFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSENMLLQLLDCLEKCKKISTRRAELLKVENNNNPHLALIKGFLKVKYRLVEENEIETLKLHSKLYNARKNELVSVRNIRPRYEAVFCIFQDRNVFWSADRLCQHCEKSGKTVNHLATRLVRYLHIVLLNKYKFKSSKRIRSHPEQEILDNEYAEIRVDTRIKTDTNIFILDKKKNNIKLIEIGITSQDSLQIVETEKLKKYDRQATELSLIYKCSVEIIPYVMTWVGIVTKYHEAHIKRLEIPMNVEAYIQAIVLKKTVETISFVQARGLDSRYNVEDSWKRTSKYTNTLLKQASIEEDGIDDKHKERPDFEEETTMVKEVKKMHKDRMLVSVFFTVNTKTYFFRKNQHIITLLMRLLCAMSSATVNFFVINDENCIQNLFASDLTLEMIFAENKSVIWINEEEKITIFKNNILRYEAPSKQPKYYNPNIHTLHHWNNMLFNSKLIKKHLDSKSTNIKIFLKDISYPALLLFLKLIDNSDSFISQINIQDFLDILLIITILDIEKTKERDYFLKDLLRNVMSEMLRQDSTLYFDNNLCRYHYSYIKKSLFMDIWIFFINFITFDDKSAQIFIVLSGNRNLCFKRTYMFSDSYTSLKKIENNQLYLRFDDISIRNIYKIRNQKHYMNTWIFLLKIVDLDLLYLVFSTEEIYKKATVLFSSVTFNAEKLYIVTAKNSIKLFLNKQIPVISNKLKVLKLESSLTSEDFKKLFGFCGDITKLTLKLESLDFQGLKIIKKFCLMNLNKTCNIFCKIYELLNTDFERIKKIPNNLKIYASKLQTRSVDIELSTVSTFFPSIYSYKYIYLKNLSLYNFFLLLECFKFKSVSFDFTKNSSPYKLEDSVYRYLRYIQTMKYMFLANIYIRDTLLEYVLDSNTIVSLDLSNSVCSYNLKFLSTNPMTNEKLKTIAINTISSGIDSSFLIYLNNFKAIEIFILLNTEISFTTSLEENNHYNFIVEEESKIHLKYLEVKTKPDSMESSNYLNFLSKIYNFSSLLSIVYCVFSISEIEYQYFLKMKQLESMRLKIRNRTECIDFGNVFNYESFNTIILLLIDVCLIRIKDIEIFKKFKNLGYFSIYCDNFDNGSIFYIKKKDFKRTVLVIERPNRASRSNEINNYLDSEFRFKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3W7</accession>
    <name>A0A4Q9M3W7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0011p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3W7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23218" checksum="ADBE72B0787C3FAA" modified="2019-07-31" version="1">MTSEILSYLSKFVNFECLNISYEGSVTRVSMGLDMYFPNLNEMIFSDMKINRLNLNFILLSKLKSLCFERCEIKNLNWDQNSNYEVFKECKRFLCLQNFDHDLIFLIFLFEFSCLEYISIKDLKFDNPWTAINHKINSFETLEYVHIDNSGSSIFALFLKNLSFSTALTVLKVSVCGDTISNFLELSNSNITKTVEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M403</accession>
    <name>A0A4Q9M403_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M403"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13778" checksum="9A3FF66E42CF7C0D" modified="2019-07-31" version="1">MVDEIVFFWCYISDEVIRALNANLNLVNLKKIVFIESEFDTVFIFTEHLSNIEEFIFYEKHYYERYTAPEIKEGDLNIAENMIESFKHAYQKHSIEENLSRKIKIYQKKKKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4A1</accession>
    <name>A0A4Q9M4A1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0083p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000083">
        <property type="protein sequence ID" value="TBU20366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4A1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4A1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0083p0030"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27379" checksum="DC07C8EA7E3FCE47" modified="2019-07-31" version="1">MFDSSIWKTIGGSKNFCAYKLTTDTEPPLCKNPYNVTGLCDEFSCPLSNSKYATLREINGGIFLFVKEPERVNSPINMYEKIELSSDYNIALEEIEEHLKYWDTKVVHKCKQRLTKLTQYLRRLEIIKKCERNIYSVRNKKIVRRDKSRAMKALNKIDFETDIKNELIMRAETGIFGENIQENIKNKIKMKVEKVKNKAKKKYVTDFVESESDCEEENLPKNVKPKKKNSIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4P8</accession>
    <name>A0A4Q9M4P8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0052p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4P8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="276" mass="32062" checksum="16481CBC96347AB2" modified="2019-07-31" version="1">MSNSFSGKNTNENKYDFHISKTPECIECENHLVSKCIVKTSGSHDENLPLTTIRNPRNQKVSNNDRERIIEKTLGPFYYSRRYLKTALVFVEKRDGDRRSKLTLEIKERLLARWVKRTFNVDVSTSTIDRAPRKFLFPLKRVTLVSELTRPGRGHNMRCEFAYLSVTAARSRNISVVAAMNKYGMIYHNIHERAVNDEDFKLYIKEINESIQRRGILTPIFVIDNARIHHCRGLNDDEEIASNSSGARTEPQLRILICEKFNEITEEHCSSFSVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5U8</accession>
    <name>A0A4Q9M5U8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0009p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5U8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020215005" evidence="2">
        <location>
            <begin position="19"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="586" mass="67451" checksum="29705AF75DF0DFAE" modified="2019-07-31" version="1">MLIIFLSIALCSIDDLDGNYHSFSDEDDFSDSLSSFTPKSNNERADHNEPTDQKDETSTLEHKIEPELNSFSHETDFFSCDSCTTCKYSSVVSRALQNKCTTPKYNSTPDFKESEKKTVSLKGRQDKHLQSNSGVCNATDPYEGSKKNSKDYQGWLFSPNNSMRYITTGIGSSIAVLRDIKSLGPQTRPGEISEPYMFRNPNTIAHDPKYDYKIFYAEDEIYEEKPQDSVHIDIADSKDVLEIEEAVNAKYKKKRKKLATQLEIMDTIEEEDCSDEFDFSTYDLIFTENTMLDLLTEDINSYLPSFFNLIDLLNISTKIDDNNSQNNSIDSDEQSSAELSEHENTPVSIKASKEDELKAKKTSKYSILPIVHKNTVSKTPTLIQSNKNIKVSNLIQDTASKNPVIYVNEEEVRFQNKVNFIFDALKYISSQMILGKPIIKSQRLQALIRRITVCAKKVKKEFMSNHNANKPSPKDEEAHLYSNLNLERIFLNRLYKRLMTKFTGKKKSVSSRLKENTEVYFYNIEPINFTLSDKTKNNKIKTRLVPNEIERMKEMERIKILARNFVSFDCFYNGKNSCKSRKRTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5Y5</accession>
    <name>A0A4Q9M5Y5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0002p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5Y5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10289" checksum="998ED16FA2EAD3B1" modified="2019-07-31" version="1">MEDRSPLVTSYNKQRILQANSAPGMSEKNAENSWEKALLSVIERAELHQTPKSPLKHVYNAEYSEPTINVKEESDLEESSEVIKMEEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW77</accession>
    <name>A0A4V2JW77_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2578p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002578">
        <property type="protein sequence ID" value="TBU06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2578p0010"/>
    <dbReference type="OrthoDB" id="112314at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="16342" checksum="E0243F2247AA47B9" modified="2019-07-31" version="1">MNKYGRIYHKIHERAVNGEDFKLFIKEINESCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVFSVWKNKVIRGGARTEPQLRILIYEKFNEITGEHCSSFYRKMLGYLQKAEVGQMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX63</accession>
    <name>A0A4V2JX63_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1660p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001660">
        <property type="protein sequence ID" value="TBU10592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1660p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54989" checksum="CEA854D3E439D8E0" modified="2019-07-31" version="1">MTDEAKEFLEVIGLEIKKEKSAKNDACCVSVYKYLGIIENSRGIPKRSSFEEVQSKLISRVARLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQILDCLEKSKEISTRRAAILRVENNNKTHLALIKGFLKVKYRLFRETQLAKLYNEIEKRKLHSKLYNARENELVSVSDSSRWLKRGNIRPRNEAGADSVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEIKTDVKIRNNRPDIFILDKKKNEITLIEVGITSQDSLQIVETEKLRKYDLLANELCLFYKCSTYVKRLQILMNVGAYIQSIVLKKTVETISFDRRRGLDSGLNAEESWERGSIGVIMRSEMHEEPTASLKVARGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX64</accession>
    <name>A0A4V2JX64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1648p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001648">
        <property type="protein sequence ID" value="TBU10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4V2JX64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1648p0010"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1373" mass="154978" checksum="63101A04AC6D89DA" modified="2019-07-31" version="1">MSTFVFHGYDILSCIRKVLFSFVMPGESQKVIRVLEAFSSKYYEDNKVEIGLDKELEGDNSDVLKGDKSDMLEGDKDQDSKLHPVSNKDVKQHPLSNSTSEQHPLSNSTSEQHPVTDKDSKLHPTTPTNNNNTTPFTLHDIYILSYAIIMLNTNLHNINVKIKISKESFIESIRNCNITPYYNNEYLLSLYNSIKDKGLVFNDSNCMGVSNYEVYKELTGYYSSRDSVRVCKGCYGNRGCYSNNTSKDKYSTEKYSNNTSKDKDSKDNYSNNTSNDKYSNNTCKDKDSGNTSNDKYRNNTFTCINTLYNTSVNNNTPITIGSDINTLLSKCSISKDIGKDIGNTPINNNTVNNTHIAISANSNTPINNTPISISTINNTPLNNNTVNNTTPISLSYTLCPFYIISSYTYIINNTYKSITPIIPYHISCYYIEICKYLHLIEPLIYYLEYISKYLDVKIEEIIDIFIEIVQDIDKWYGDSIGVGVGGFSNLSDEQQGVSDRGSNIKGVNNLSDEQQGVRDRGSNIKGVSNMDSNIKGVGDMDNVLEGVSNMDSNIKGVGDMDNVLEGVGDMDSKQQGVNITSNKQQGVSNNTDEQHPFNNTTNEQHPFNNTTTNITTTNHSQLLTLLSLPLNILYTLYTKCKKKEHFISKYENVYNKYIRITSSLPDKYYILLIKYIVYNDSSDKGDSTNTLHPVNAGTNNYNPVNTSTNNYNPFNTGTNDYNPLNIVTNDYNPLNTSTNALPPVNTSTNNYNPLNNNTANNTPLTTQHTNNTPSILLSNNTFYLWFLFLIIDRNCFRIKGVLNEVCIIFKGNINYMSYLIEKVVELRLTGVLCTFIKEWRLSVISVLDKCVKEDSECIDSSVIDVIERYIFKYCSVEECMLEGDRVVEGVSAKSMLEGVNHKSSNIEGVRDKSMLEGVSDRGSNIKGVGDTTDEQQGVNDKGKEEGVNHKGSDIKGVNDTTDEQQGVSDRGSNIKGVNICTNTQHPVNNNTNTQHPVNNNTDIQHPFNNTDLHLCFNFVLNLQYKYDMFKYVVIKGCYYNYTYIMGYKNKRYFIERFDVCLKDIRNVFLFFMKCNSVMNNKVVERYFMRRGDSVNTSKSSKDLSNINSTTSVSSNIDNTTSVSSKDLGSFNNTFCGTIEPSTINNTSYDTRNVTNTPLNDSTVNNTPLNNTTVNNTPLNITPSLCPIDDLLFTDLEERICYMLYKVDTINNTKLSRYVLWIVNLISSSLPLFLRVFKNNLEYFKNMNSNSLMSICKIFSSRVCKVMDGEIVCVEWCNKEHKDVYEEVYEVVDVYVSNGVVGKECFTFIGKEREGEGKEKVDGKKKDSESKDSIVEDNSIIKDNSIDIVKDNKVKDVKGDDNDNNSVDNEVYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC2</accession>
    <name>A0A4V2JXC2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1307p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001307">
        <property type="protein sequence ID" value="TBU11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1307p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27553" checksum="3882FC9B49270CA3" modified="2019-07-31" version="1">MLGHDYTRRHNKVVRCLHLLLLNRYKFKSTKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNMITLIEVGITSQDSLQIVETEKLRKYDLLADDLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVEPISFDRRRGLESGLNAEESWERASMGEDGAKNFKPKNKATLISQGGTTLEEPTNNINEEPELEEETVVVKKVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY20</accession>
    <name>A0A4V2JY20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0277p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000277">
        <property type="protein sequence ID" value="TBU17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0277p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10072" checksum="BF62FA4B2905682F" modified="2019-07-31" version="1">MKDDDNNEYKFLESLKNSERQMLEGATCPCCDKYYSNYNSVNKSSRHRNKSRRSITPPGSRNGETFSTDLFVVFYETRLETTAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB2</accession>
    <name>A0A4V2JYB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small Rho-like GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0429p0020</name>
        <name evidence="11" type="ORF">CWI38_0071p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000429">
        <property type="protein sequence ID" value="TBU02701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0429p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0020"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU02701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="191" mass="21754" checksum="A9E60D56C5028D4C" modified="2019-07-31" version="1">MSSLKCVIVGDGGVGKTWLITTFITNESPQAYLPTVFDNFTATIQYKNKRHVLSLWDTSGQEEYSQLRALSYPQTDVFILCYAVNNVVSFNNIKAKWYCELKQFNKPILLVATKVDTRTNNTNNDMVTPEKGIDLQKKLHINDFIECSALKKTKIKEVFEKAIECTYKSKKRSSFFSSCFGCCCHKTAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF1</accession>
    <name>A0A4V2JYF1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0011p0020</name>
        <name evidence="11" type="ORF">CWI38_0021p0190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="2"/>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0190"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="166"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU05450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="452" mass="52840" checksum="170169806FC53F30" modified="2019-07-31" version="1">MKIVIFGASGDLAKRKLFPALAKVEGGAPDLKIIGYSRAKLEDNFITKITEFETYKQSFLDKIMYISGEYSNLEKLKDFVDEETLFYFSVPPIVYPTLFSGLSIFSNPKIAVEKPFGNDLKSFLNVRKFISQHENTRIYLIDHYLLKPMCVALPKILSKRDSIRCLLNNNCVRSVEIYIKEELGIEGRSYFNDYGLVKDVVQNHLSEIFCLLGCTYELSMDSDSLKEKRVQFLEKVKEINIKYTLFGQYEEYNKELGFSSDTETFVLVPLFVENERWKKVPFVLIAGKGLNEKRTEIRIEFKRKSLARVCEFLDSSDQFKNHIEIPVKDIEYFELIINVFPDNEIYFRFKSKEGFIKLVIYESCDIDRMMVENYGKYKDHEIIFNSLINNHEFACAGVDEAEILWNLFDEKKLMPKSNLFFYRKGVDMPDIASDMIVKLKEKNDSMFDSFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KV89</accession>
    <name>A0A4Q9KV89_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1584p0020</name>
        <name evidence="4" type="ORF">CWI38_0349p0030</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001584">
        <property type="protein sequence ID" value="TBT98812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KV89"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KV89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1584p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0030"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="285" mass="33238" checksum="7F5730BB010D5991" modified="2019-07-31" version="1">MSLLSVEYLIKSLQSLQPTQDSMQTLSLYIKTNTSEYEKIVLVWAAEFEKSNIYHKLNLLYLTNEILLTIKPNDPKHGNLLQAFRNVVPLRFKEALNQSQKNTILSKKYYDLGKVWIQRGIFQMEDLFKNLEGIEISEVPQVNKKSKESSEIGKNTIKKEKRGVSKVILHEENTSETKKNGNLNCFESESSSQREVKDSKFKKNLTQNDDVKTQNNNQNRGVNRRGKSGDANSRNELKDKNSDLKRIENEKFKKENIFQRIEEYFETKQALISYLEEFIEALKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVW2</accession>
    <name>A0A4Q9KVW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1503p0020</name>
        <name evidence="6" type="ORF">CWI38_1518p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001503">
        <property type="protein sequence ID" value="TBT99008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001518">
        <property type="protein sequence ID" value="TBU10844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVW2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KVW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1503p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1518p0020"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT99008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="392" mass="44064" checksum="A5B8E9ABD114B35D" modified="2019-07-31" version="1">MSCRKFEAPRHGSLGFCPRRRAKNIRPPVSSFPTDTLSKKPHLTAFLAFKAGMSHVVRMTEKSVLKRSVATVTSSEVLDAVTYIESPPMVGFGLVGYKNTIYGLKRTGCVLSQHLSESVHRRMTRNFYRYRTSKNSHTLKNNPNNLSEEIQKIKENSDSIRILVHTQVEKIPNLKTKKANIAEIQINGGNIQEKVEFVLSKMEKEIKVEEVFETQESIDVIGVTKGKGFEGVTKRFGTRILPRKTRKGIRKVACIGAWHPAGVLSTVPRAGQMGFHRRTMTNLQVYMIGNGHKEFNTEYDLTVKGINPMGGFPHYGNINNDFVMVKGSIMGPRKRVVVLRKSLSKEKPKLENVILKFVDTSSKIGHGRFQTSGEKKEFYGILKKDVKAGGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXH0</accession>
    <name>A0A4Q9KXH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1471p0020</name>
        <name evidence="3" type="ORF">CWI38_0801p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001471">
        <property type="protein sequence ID" value="TBT99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000801">
        <property type="protein sequence ID" value="TBU12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXH0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1471p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0801p0020"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ssl1-like" evidence="1">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="366" mass="41822" checksum="38F2983CE6EFF6BD" modified="2019-07-31" version="1">MSPSNFFSWEQQYKRTWEDASPSVTSFKQIAKKYDNRPLKRLTIKHLHIIIDTSVNLDHPDFHPFRFSLISILKEFHKNFTFRNKVSKISFSNLQLEYYNEPTTNLLELCEKLFDIQDIIQRSLIMIDASTKLLNEEPAGIAKINSSKIFKENYKEQTGDQQKILKVKNTCLKEFLIISGSLSTKSVSSDLFHFIKKNNLKIHFISLGGEVSIFKKVSQTTGGKYFVPLNIHDFANILMEYCIPEILTSNFVSMIPLGFPLFSENENSVCVCHSTICKGYSCVTCGAKVCTLPISCPICNTQLISSSSLIQNIYYSFPLKQFSVGEGLCKICGLDGKWMCNDCKNTYCDTCDSFIHENLKFCLFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3Q6</accession>
    <name>A0A4Q9L3Q6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0542p0010</name>
        <name evidence="5" type="ORF">CWI38_0753p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000542">
        <property type="protein sequence ID" value="TBU02153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000753">
        <property type="protein sequence ID" value="TBU12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3Q6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3Q6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0542p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0753p0020"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU02153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="273" mass="31670" checksum="AAC1091D84F3AC5A" modified="2019-07-31" version="1">MTIQRLINKIIKNNKNIKVLIIGLDNCGKTSLLYKMFGKSICDVVPTFGYSLFSVEYFFRRKLFTDQLDVERFKNSVCCNKEGDMEGMGVERMGVEEMGVEDISKREMGMEDISKRGMGMEGEIKNMNLKKNIQETIQDCREQEIYQSIEENLVQNLDCNDIYTLTIVDVGGQSLFRKYWSSYYEKVDGVVFVYDLSDNRKYEELLEEIVNDVELENVPIVVMGNKCDLVGFKEEESRYDKYGDVRFIYTSALTGKNVRNGFEWLLSKIIANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L522</accession>
    <name>A0A4Q9L522_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0436p0030</name>
        <name evidence="3" type="ORF">CWI38_1156p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000436">
        <property type="protein sequence ID" value="TBU02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001156">
        <property type="protein sequence ID" value="TBU11529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L522"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0436p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1156p0020"/>
    <dbReference type="OrthoDB" id="2188707at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="27224" checksum="781E032715E9E1B5" modified="2019-07-31" version="1">MASDVGNVGFVRKIITEINEEIENTIGLLKVYVCNKRDFIRNKKDSQKYEIQILEKEIMYCKERDTNFMKEKEFLIKSIENEKKDLECLKKEKCKLSEQVCCNEEKGKHLSEKVENIKNKLEILTKKIDFQERKNAKNEKEIENEISLYKKFLGIDIFPIKNNFIKILFKNVGEESFIVMEFGSKISVVEVFPIEIGIEAINSLFYKISDFKEFLKETRNLFIQFHKCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8S4</accession>
    <name>A0A4Q9L8S4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0347p0040</name>
        <name evidence="6" type="ORF">CWI37_1104p0020</name>
        <name evidence="9" type="ORF">CWI38_0556p0050</name>
        <name evidence="8" type="ORF">CWI38_1239p0030</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001104">
        <property type="protein sequence ID" value="TBU00121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000347">
        <property type="protein sequence ID" value="TBU03150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001239">
        <property type="protein sequence ID" value="TBU11378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000556">
        <property type="protein sequence ID" value="TBU13027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8S4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8S4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0347p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1104p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0556p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1239p0030"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU03150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="148" mass="17351" checksum="5A5B8B8EFAA59736" modified="2019-07-31" version="1">MKQPVIPSGVSQNVAWTLQKGSWITHITVTILVKVLYAQLFNPNLSWQLTILTYNFCSFIFFHWIIGDPFDHQYCGHTFWEQMTEQLENSPSLIFLCVYPVVLFIIGNHIVEWNAIMFYLCVFSLCIVIIPKFGFMHRKRLFGIRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9L9</accession>
    <name>A0A4Q9L9L9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0135p0010</name>
        <name evidence="13" type="ORF">CWI38_0754p0010</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000135">
        <property type="protein sequence ID" value="TBU04437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000754">
        <property type="protein sequence ID" value="TBU12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9L9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9L9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0135p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0754p0010"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU04437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="404" mass="45441" checksum="94DDC950989C3611" modified="2019-07-31" version="1">MSLEKLKDVISNIANEDPEIVDERISLLGSELRGLKGEVTNVDYEIGIRRTSTSENYEKIKLHKTLPYLVATVIEVLYCEKTGDVNVVLMTSTRVNMLILNPGLVDPAKLLPGTLVGVQKESNVILEIIEPEFDTRVKAMELEERPLENYEDIGGLERQIEELNEAVVLPFLHPEKFIKMNIRPPKGVLMYGPPGTGKTLMARACASKTKATFIKLAGTQLVQMYIGEGARLVRDTFALAKKKKPTIIFIDEIDAIGTKRVDSDRNGDREVQRTMLELLNQLDGFAVNDDIKIIAATNRPDILDPALLRSGRLDRKIEFPLPNLEGRKRILQIHSRKMVVQDNVNYEELARSTEGFNGAQCKAATVEAGMRALKKKREEITQNDFMDGIQDVSAAKKSRYHYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAH7</accession>
    <name>A0A4Q9LAH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0090p0060</name>
        <name evidence="10" type="ORF">CWI38_0187p0050</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000090">
        <property type="protein sequence ID" value="TBU04773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAH7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LAH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0090p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0050"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU04773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="157" mass="18542" checksum="39AFA7A8F712DB27" modified="2019-07-31" version="1">MRATPPKNVKFIDSTREILNSYNKSKCSKRTRTKLSLEQLNALEESFQSSAHPTNEIKEVLSKEIKIPVKNVQIWFQNRRAKDKAVKETVTHRSDRRGHFEHEYIEYPPHQYIPYGGYSSRGRDNGYYHINDYGYYDQSYDGYYGDSGKYGDKQRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCD0</accession>
    <name>A0A4Q9LCD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0004p0020</name>
        <name evidence="2" type="ORF">CWI38_0002p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000004">
        <property type="protein sequence ID" value="TBU05519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0004p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="122" mass="15113" checksum="5D0F96BB044B160A" modified="2019-07-31" version="1">MNNRKNHEDKKNHHSERILIRNAIKRMFKEDNKHLNAAIYQKDEKFLFFSLNEIVPMFLKMVRDTMIFEQRVAKIEYITYHKIFPLLKEAKEILYNYYCNFLYFKIDLDKNYYLKLLVSCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGU3</accession>
    <name>A0A4Q9LGU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2416p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002416">
        <property type="protein sequence ID" value="TBU07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGU3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2416p0010"/>
    <dbReference type="OrthoDB" id="4354971at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="561" mass="58585" checksum="72B25182C0A90BA7" modified="2019-07-31" version="1" fragment="single">MDTIRKRKIIFVIFTACTFIMIMGATFLMFSLHCANKMLKSFVDELETAKKNPHYKEIHQSLVASNTCCFYLDEKDGKKAYESGIFIKASEGKKKLGNAIANKKYEEIKISEFCDTKMFSMNFNVDITKLKKQADDVGSLAKIGLFFKRKNQFRSYLKLTSDVISAGISNKSKQKTCYIEVKDDKKILVSTLRVNNNNKIEEESRRNLEFEGYKPLSEYKAIEFVAFVFYTSCSIISPPPPPPQGSETAIGIGSTPLPRSQTKTISRQRTGPETTLLPVPKEIPPPGSQKTQNLRKGKRPVNPEHPESETELEPGTDSESDSEPGTRTGYRTGSGSGKAIGTRSAQGTGSGIGSAQGTGSAQGTRSVQGTRSVQGKRSGIGSAQGTGSVQGTRSAPGTGSVQGTGSELESDSGSESESGSESGSAPGTRSVQGTGSAPGTRSVQGTGSVQGKRSGIGSAQGTGSVQGTRSAPGTGSVQGTGSELESDSGSESESGSESGSAPGTRSVQGTGSAPGTRSVQGTGSVQGKRSGIGSAQGTGSVQGTRSAPGTGSVQGTGSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHU2</accession>
    <name>A0A4Q9LHU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2553p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002553">
        <property type="protein sequence ID" value="TBU06550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHU2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2553p0010"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU06550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9183" checksum="6CD4A60E01834A39" modified="2019-07-31" version="1">MPSKGYKSDNIIRHILPNSYKKVIVSNIKDLEALTSLNRFYCAQIAHEVGAKKRIEIVCRANELDILVLNKDARLVSEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIM6</accession>
    <name>A0A4Q9LIM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2316p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002316">
        <property type="protein sequence ID" value="TBU08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIM6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2316p0010"/>
    <dbReference type="OrthoDB" id="2195824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="39061" checksum="BC5E3C904D3D960F" modified="2019-07-31" version="1">MNDSLPKAVVNEFFKRLRSYNCNSKCADCNKKTPIWTSLTFSVFICAECATKHREMGVTITKVKNTVLDSWTLPDLRRMSVGGNERALVLPQTLDIFEKYRVSKWYSIEIDELVTISEEKMPNDEFLKVKESVKPRGNRNIVIEEKEPPKLGSAVSHIPTESFEKNNENAKIQTKKDKSKEKKESVCFVNISTASSGLQKADTPSYKLTDSSNLHRVGLGNVQLEKEEDKGRYSYKCAPVKHVYVPKSKNEKDDVVKDTIKKIAQYLEFLENLFLLTWTSIQVRLEAYIQSIVLKKTVEVIFFDRRRELQSRLNTSESWEMVNWMYYIYKRYMNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIR4</accession>
    <name>A0A4Q9LIR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2310p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002310">
        <property type="protein sequence ID" value="TBU08068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2310p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="276" mass="32444" checksum="97E019F6156E56B6" modified="2019-07-31" version="1">MEIAKILFEKNIKGSFFSKDMKYSKVRIFYFLCIFFAISVVSYEIIFMKKYINDLSNSTEIFQESEILTQLYDSVKGIVKIEQKNITEKYIARLWLQIYEILTCLVISLIFISKKARKIIFKKLNESNTTEISFLTLKKSEILYFTLFVILIFISTIIKYLLFGCRIGFDAFDFRSRIKQDIPIIVIIPYSSLFLASLFLKFWKRKYLYILIIGLIIYTPIVRNFKKMGDPTIAGYERIDPTTLDIQIQEAITKCELGNDIFVKKTGSFLRMVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIV9</accession>
    <name>A0A4Q9LIV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2329p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002329">
        <property type="protein sequence ID" value="TBU07937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2329p0010"/>
    <dbReference type="OrthoDB" id="2190422at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="386" mass="46297" checksum="8635FFB3322C6749" modified="2019-07-31" version="1" fragment="single">SYPEKCNLIFSKVDEFDLSKYKETNLNLMIDKYSNICKYLANILFENLKKYILKNKIEKNKLKNSFLVFSNTKYFTNDLDRFILDILMKNMIDLSKRDRENVELQEFKSQNHQIPKIISKNYLKLITNFKKLNEIDIQDNEKVFDTIMKIFVVFFSQKKTYKSLTDLFSLFCDLTHFIKLYESIFYDESKDKNSENKNFNNFLKSKKEEIKNSIQNLEKSKKKISKKIFEKGGQIDFIFLGENTKEFKSKIKMKYKLFIDILNLMLPESMKLSIEIGYSEYIYMQYIDYVLFLPEISYKECDTLSEVGQFIIDLESIPKNYISNYPKILAISEILQMNLNELEIYIKKNKNVFSYTEISGMVNSMFEESEKRERFLKNLKNYLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKI7</accession>
    <name>A0A4Q9LKI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MRG-like chromatin modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2220p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002220">
        <property type="protein sequence ID" value="TBU08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKI7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2220p0010"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="134"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="294" mass="34905" checksum="519A29498EA13100" modified="2019-07-31" version="1">MGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETIVVKEQVETQQKKIYINNYIITKSRDEWIEGRIIKIIEVPKPSEEKPDMNIKKYIIYSLRHNIICEEEIPEHSIHQDIHIPVDLFEILKNDYKSVKDKKMIVLPSKFPISKILKEFSKFIVANKPSISEDEILEVVKGFTWYFDKLINPFILYECEIEQYIQYFEKEKNVNLPSNCYGPEHLLRMIFAIQKFLVKDCMDYETQDVIFEYSVYLCDFLNIFLKKYFQEKNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL17</accession>
    <name>A0A4Q9LL17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2348p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002348">
        <property type="protein sequence ID" value="TBU07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2348p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="18971" checksum="3324C93BFA6D56F9" modified="2019-07-31" version="1" fragment="single">MVNKERIFNEGWVFFCVNVNIKKNKLEINICVNIIESKLMGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLR8</accession>
    <name>A0A4Q9LLR8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2163p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002163">
        <property type="protein sequence ID" value="TBU09293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2163p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42579" checksum="D8804B905E1A74EB" modified="2019-07-31" version="1" fragment="single">LPRKELGRGLDSVERAAILKVVNSNKTHLSLIKKFLKIKYGLEEEVTKKKLEEAELANLYNEIKNRKLHSKLYSARNNELKGSLKPLDGAVVCYIQHRNVFRGAEGMCQHCNQSRKTVDHLATRCEKMLGYDYTRLHNKVIRCIHLFLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRCNRPDIFILDKRHNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNHEAYIQSIVLKKTVKTISFDRRRGLESGPNAEESWERALLSVILGAEMHKQPIPPLKQVDNKEDDVKTENTKNILPLILYGLTTAKEPTTNTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMJ1</accession>
    <name>A0A4Q9LMJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2135p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002135">
        <property type="protein sequence ID" value="TBU09593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2135p0010"/>
    <dbReference type="OrthoDB" id="5987059at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="9638" checksum="DD595398CF1C9CC9" modified="2019-07-31" version="1" fragment="single">MLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPQ5</accession>
    <name>A0A4Q9LPQ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1775p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001775">
        <property type="protein sequence ID" value="TBU10418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPQ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1775p0020"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF4">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="11">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="502" mass="58695" checksum="4F63D19D21AE8FBD" modified="2019-07-31" version="1">MTMENNLEEKEITTKLKLINAFTKNKDIFTPSRGNLIRWYICGPTVYDSPHLGHARTYVSFDIVRRVLENYFGYQVTYVMNITDIDDKIINKAKETKMEVSDACKIITKKYETEFFEAMDNLNVQRPTFTTRVTNYVEKIVTFIEKLMEKGFAYESEGSVYFDLVKYRENFKHPNFVNESAINEETEELENIYKKKNKIDFVLWKKSKEGEPVYNSPWGEGRPGWHIECSAMASDLFKDGLDIHSGGCDLAFPHHENEIAQSQAFLNSNLWCPYFLHSGHLSIDGLKMSKSLKNFITVEESLKNFTPRQLRILFLNTNWWAPMTYKLESMEYSKKIEAKLMNFISISDSFIKNSEIEDNFKNVTDQDSMILEILENTKISIHEAFCDSINTFKVLTAILNLITVIHQKIENLSIRVIYVAKQYVVSILNLLGVVEEKKGFDSLDQDVLKLVCDFRANVRKYSKEKKEHKHYFELCDKLREDFKTHGYLIEDKGEESRIRKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPX1</accession>
    <name>A0A4Q9LPX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_2026p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002026">
        <property type="protein sequence ID" value="TBU10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2026p0020"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="93"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="38040" checksum="EBDA7084C422F6F3" modified="2019-07-31" version="1" fragment="single">MDKIIKEDTKDEKLTTVNEKEELLKNLLEKLKIAETKYGIDITEILKKDVVRTDDVTTTQFSKWEEFIKNTNLLKGIENMDYKYPSPVQAASIPYSLEGRDLIVRSKNGTGKTAAYTIPILERIDDNKMMPQCIILVPTRELALQTSKMCKKIAKYMKIEIVPIYGGIDLHDDILRLTQGVHVIVGTPGRILDIAERKIINLKLCNILVFDEADKLLSFEFKDSLDKIIKFLPVDRQILLYSATFPSSVCEFVNSYMNKPLHLNLMKELTLKGVHQFYACVEPKNKLFCLKTLLKQLNFDQCIIFCNSIQNVELLTKKTTEMGFPSYFIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ62</accession>
    <name>A0A4Q9LQ62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1833p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001833">
        <property type="protein sequence ID" value="TBU10347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1833p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9246" checksum="6DB0521F78E3019E" modified="2019-07-31" version="1">MLVCHANFKVSGDAASAGDTHWVLEVDLIDVIALSRWLEHGIIRSRDEAVFCYVIDIKSILVEEKSRMLRDDYIGRQNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQA9</accession>
    <name>A0A4Q9LQA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1923p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001923">
        <property type="protein sequence ID" value="TBU10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1923p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19483" checksum="ABFF989D4435DB43" modified="2019-07-31" version="1" fragment="single">MVVAGKARAIRYFTNSRNGFMKIFNEEFSVLKSSLKLNKIDFSNYRPRIAVTIIYSLLQTTLVSIIGLVVSLLKSKTDFNFVFYPVSFGCILIYSYGAGYFYKACFDKRDSYTFFMHVYICMYSISYLPVFCILQSIHRVLSWIFFLAFWILSEYALCLNYRDMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG6</accession>
    <name>A0A4Q9LQG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1600p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001600">
        <property type="protein sequence ID" value="TBU10698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1600p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="45621" checksum="6A6B8C67D8F6B748" modified="2019-07-31" version="1" fragment="single">MFFISYLGIFRNFVKSAIESLPSNYYAEEYKIDDHIKRHNIGAFWCEDIMGTPSTYLHPSTTLIQEFLPCKAEHVGKSTDEYSIPFSYNALDSHMAKTSQNPIPSNNTHAYHTLSRIPRFSASDSTQTPSCMNTLLNIDEKDTENPFPKEIPEEYYYKTDLQCQISEKIKKLTQICKRIRKDKINCTSYSDILCFLDDSYRIRNLFLKNIFMNNCKLFRKLRNIEAGMKEYWQDERILKEVAVIFKARIDQIEIAKKNCAILSFFPGLIFIKDFINKRFTNMSLNERPMISIYYGCKIIESILHYDSLKFTELNHSFVYGENSEYPKFRLCRNSLQITKNYLLQILNIVRYIYEALEMRQIDQKMTKLIKSACYYLKNDFRNNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQH9</accession>
    <name>A0A4Q9LQH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1862p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001862">
        <property type="protein sequence ID" value="TBU10306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQH9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1862p0010"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="6"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="282" mass="32374" checksum="9AC62BF32411D47E" modified="2019-07-31" version="1">MMLRRRNIGFSIMVAGPKGIGKSSFINTLFNREIVQVQKKSNENLDLNLYILEIDCEGVRKKVTVVDTPGFGTTLDDSGTQENILSYIRTQFNMFLAEETKVKRNRDFEDTRVHALLYFIKASPHGLKKTELAFLKKVNGLVNIIPVIGKADGMAVDEMESIRSRILDQMKTCNIEIFDILKDELINQSLNWVNLISKFPFSVICDDKIDGEENTVRGRKYRWGNVETDNQEHCEFSLLKEILMSSHMDALIETTVNDLYERYRTKVLSEILPKADLNNKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQJ6</accession>
    <name>A0A4Q9LQJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0564p0010</name>
        <name evidence="2" type="ORF">CWI38_1848p0030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001848">
        <property type="protein sequence ID" value="TBU10326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000564">
        <property type="protein sequence ID" value="TBU12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0564p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1848p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="20600" checksum="40872767BA62B36A" modified="2019-07-31" version="1">MNINNQNDNFIKEIRLLNKSRQIIQEELNKERRKVIEIEEESKKKDIEIERLKSNIKELKLQLNVSESKRKRNEKIMKIQMNKKEFEGKKYLKTNRNKVEYDLKSSVSKYEKRIEVLERIIESLGHKFMFDSSILLSCNEIIDGYEDSLVDIFLKNVSSVNKENEGEEGKTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQP7</accession>
    <name>A0A4Q9LQP7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LSO1/LSO2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1499p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001499">
        <property type="protein sequence ID" value="TBU10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1499p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9598" checksum="4A978019DB259D90" modified="2019-07-31" version="1">MGKTRNFEKKLEGKLKKEKREQEKKRKEDEKREEELTKFWAIGAKDESKKNEKEVKRQEKIQNKQKNKELFLKEMENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB5</accession>
    <name>A0A4Q9LRB5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1464p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001464">
        <property type="protein sequence ID" value="TBU10944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1464p0020"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="34353" checksum="7890888AAB06FC9F" modified="2019-07-31" version="1">MTRFNKSKTKKTITKYRQNKKFETIYGTKSLDQIQKDIKNNTTELNENIYYCIECSRNLNTERDFMAHKKTTTHKRRVKMLKEIQHTQKDAEMAAGLYYIYVSRLLISCGNGKISLLRLILIYRTRFLSPKNKNLLSAHLMHQQRLRHEIGNFEMILPIFHSSNQLVFRARLFLRRMNYIKNFFCKESGKFIPSNLVMKTPAYFEKYEIGNNNDLLELSENLLHKKSRLFVDKTEDLMELADSKIEKEMPNQLEYDEKSDEKVMLKLERIYHIFIKIKELQDWIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN9</accession>
    <name>A0A4Q9LRN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1382p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001382">
        <property type="protein sequence ID" value="TBU11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1382p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="26486" checksum="395564086A7A87BD" modified="2019-07-31" version="1" fragment="single">LSANMLSLLLQVNPLSRAPCGLLIFHGFFDYLYNFLIDISNLPDFYLNISDNIKLQKIKNEFIYEEYGTSFHLIFPPNNYQIRKNLERKIIAFQQQKYNKFYENTNYSFIYSKYLSCLVGFSKEYLYSIMDLDYNSLRQIMNLKKIAINYMKGNLYKYNVNLSAIKNNIKILDKQNVFRISKPQENFSPRSISRNENSVDMKSRNEKMLSKRMKANTSTPFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR1</accession>
    <name>A0A4Q9LRR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1821p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001821">
        <property type="protein sequence ID" value="TBU10361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1821p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="26309" checksum="70062669DDB59224" modified="2019-07-31" version="1">MALDRKKAMIIASGLVISMLFIFALICGLGYNKAGNVIKSFEEDFKKVSATAQFKFITNDLNKTKLGDFASIKGKKVFELPFSSYDSAKSLIKALDDKKIEKVQVYTNINIDVTIQIDASKFINIVGEIGFLVKIGFWFKGKTAIRSICAISSFIYAAIKEDSKEKEKVFVILNLEDEKNVKGFYVKTDNDGKIKTICSPKTFKFNDSKNGLEGKSHDFVAFIVEKVRKASNSTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS94</accession>
    <name>A0A4Q9LS94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1777p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001777">
        <property type="protein sequence ID" value="TBU10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1777p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="9118" checksum="97C5F83983E5AE6A" modified="2019-07-31" version="1" fragment="single">MKTDFLLYSVINIMWFCSEKIGCAYLSEEAGANDNIFLNGTDLYASNGIFSEEAGLSGETGLTDGISVGERINDGINLGEGLGADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH3</accession>
    <name>A0A4Q9LSH3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1159p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001159">
        <property type="protein sequence ID" value="TBU11523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1159p0010"/>
    <dbReference type="OrthoDB" id="7976214at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6537" checksum="D0319CF21C3E2A62" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPEYIECENDNVLKCLVETSGSHDENLSLSTIPTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH7</accession>
    <name>A0A4Q9LSH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1399p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001399">
        <property type="protein sequence ID" value="TBU11076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1399p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="601" mass="70590" checksum="070038848CFC629C" modified="2019-07-31" version="1" fragment="single">IKTDVKIRCNRPDIFILDKIQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLEFGPNAEESRESIIKCILRAEMHKQPIPPLKQVDNEEDDEPTTDTNEELELEEEIEVVEMKEKTDTENTKNENIKSKRRDLREYPEMTDCVSELRKIKELSEEDIGDAVLMTITDLARDSQVEHGRDGFINFEKELTRKTPFFSNIKSQEIVREFIQNNQSNDPSEVLVIKNESLNVYEKTLIMYESKKKFQKDKRMFIVSFWSTMSNKNYNTVTCEEYFILFVSAYKSIDDDILSHLHEKPILTDFSSKNIRVSISRTKNDSSTMHNDPDAHANNNLFFIDDLKLQSIESSTLSTMKDALFKILLSSRRCCVYEFLGILEDINFVPLETTQKKSFDVTNQHVISLSYYHRGIFLLELINNKLHYRTGYKEWVYLSRTELKKTHTVLSKEVNKKFLEEAQLAKLYNRIEKRKPPPIFIDSSRGPKKENMRSCDEEDYTRRHNKLDTLQRLISRFEIIESILLFCNKRKNKCTLKQVGITSQETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI5</accession>
    <name>A0A4Q9LSI5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1613p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001613">
        <property type="protein sequence ID" value="TBU10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1613p0010"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="10">
        <location>
            <begin position="353"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="72504" checksum="1A5CC45719AD6C21" modified="2019-07-31" version="1">MPSISVKHDEISSYLNLDPTGETLSDLLFSYGLELEETISDPLTYKIDIPANRYDLLTPHLLSKALLSFLSKKKFEDLKIKNSSTHLTVSKTCRPFIACAIVRNIKFTETLFTNILEFQEKLHLSLCRHRTLAAIGIHDLDKTTPPFFYTEENPEDIKFTPLFSDTPMYASDLVSNPNFKHTHHLTEMSFFPVLKDSKQIISLPPVINCDETKISMNTKNLFIEVTGNDFNRVNTTLKLICYFFSEFEIEKVKILHAEKMRSKTKNCYEILGFKSGILDKPMADESINHEGLRNGEESTVNIPSNDSTTNEISNNAISSNAISNNAISNNAITNNNLSNQTQKMPFSIETPIFFNRKFSVSIVSVEKELGISINIYMLKVLLEKMMHFVTIEDNCLEVVVPDIRTDVLHFCDLIEDIAIAFGYENVPIKNVDFVSIGKEFGLNKFSDKIRNLMANCGFTEVLTMTLLSKKECYALIEIGSQFSRSKTNLDKIIPTVLSNPQSSECECVRISLLPGILKSIQNNKHLSVPFKLFECSDCVITGLNVRFLCGVYCGVVSGFEEIVGAISFILKKVDLDYNYREERSKRYFEKRGGAIYIAGVKVGTFGVVDPEFCSLFGVDFVVSSFEIDVEKIYAFFIEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK7</accession>
    <name>A0A4Q9LSK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1141p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001141">
        <property type="protein sequence ID" value="TBU11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1141p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="508" mass="60509" checksum="FE0480805A69AB10" modified="2019-07-31" version="1">MKSRKFDYKFLSISLQILLALLSIECVNTYKFVYSFEKNGDSEIFFFCENCERKAFNLPRHREDGIIIVFDVDIWYELRRENHIFTYRNENSIAFEVFNNFLYLKESEDKHENGIIGSDFELAYFLKLTENIAEFSFKLDTYYLKCILILLKCFEVVENRSLLEFLQSLFFYGLVVQKESLSRKDRFDLENAFHSDIFKKLNFSIQKSLCYTFLNMFMITFVFNDGNLIILEKANELYDILLFDKHIPYKNLLKYEKIKIRKLEISPEVYNWIFQKTYIKVIYIENYTPNDEPLTINNFTNNISLTKLVLINVRICLSFVNEIFKLQNLTKLSLESCILESFEVYLPFTLFTKNLISLSLKYTDLVLYKYADIPSQFTSLRHLNISRGNLPPSYISKLSLLCDSSLKVLHCKSYTLDKKDLLRISKLEFYNSLYALNLYSTILCNEDIIFLKKIKNLRFLSLRLYDLDIKILKSCLLSLSVEKLYCDINYIEYIDLKEYLKEKDILAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS0</accession>
    <name>A0A4Q9LSS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1341p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001341">
        <property type="protein sequence ID" value="TBU11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1341p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18584" checksum="F796DDB65F59D54B" modified="2019-07-31" version="1">MIGKIKNSGNIKKINISEVTKNQGLESSELIGILNKIYECKQDRNDMGNIHKSTFKIIKNLKLKEKEEENIKTKEDLEKADISFLEKPALKIHEINIWNHENKRFPILKYHMEYKFPIMIYKKNEIYYQSKLVDKPSQNKKQEIQFNKLENNEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS6</accession>
    <name>A0A4Q9LSS6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1336p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001336">
        <property type="protein sequence ID" value="TBU11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1336p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="135676" checksum="1033EFB948803232" modified="2019-07-31" version="1">MNSFTVLKKKKVLRIQIFYILLNIMHAFTLFKLVFSHRFNYTFRCNEKTEILIYREKQEEETFDEVMNEEYELLLSFSVGNKNFYDDKPIFTYGKENNIQFDVLNNILEENTSGTNFKYGKIQCSYELSYFLRLTRDITELPNYFNNYQLKCMLTTLKYLKAIENKNIVKFFIALVFNDCNCDNINESEKNNVDFEYITWSDFITKIDRNMITNLLSGFMSYFMIEFVFNDGNLILLQNTNDYYDILLFYKNIPFKHLLINKFKTFFALENILKNPRYFSIFRVLLDELNLKSLIINNYQASEILDVRFPYYVFSMLIFKSMIVSNITTSYIFVSYLLYVGIDENIEFLSLKNISVSTNDLNFFLRKQKLKGLVLDTVKAIENSNIIDDCVKLIETLEFVDFRNIDINYNWWKCFFLKANATSIILFFDTLTSQENFLNGLAKLRKNMNLVRLEIMFFDFEISESFCYSLRLLNNLKNLKLFNYQINKKSEISLFKSIRSLKELKKLTIQNPKFCKTPCNYSLKSQNIKVLCLENIFSNERTQLLASLFSFTFITKFFLTNIFITHALLVKISQMKHLIQLSLKFCAIESIMFPKPLDFSARNIKFLNIYDTNWNNLQYFDILGKLDNIEFLDISLCGLSASYLKNLSPGCNLKLKSVSCESGILDIDDLNIIGKLEIIEELNLSNCVFHNSGFFKLGENCKFFNSLKKLDLMFVDISIEDLNFIRKFKNLKNLSLTLSGLDLLYVKSYIVSLHLNQFITNIITYDENFKSLLENLNEMNINNALNIEIFPADLYYSNIFLFTLSTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWPKRGNIRPQNEAVFCYIQDRNVFWGADGVCQHCGKFGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRYSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRKGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDVEEETIVVKEVKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSY6</accession>
    <name>A0A4Q9LSY6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1086p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001086">
        <property type="protein sequence ID" value="TBU11679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1086p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="15650" checksum="5CE68A6716DF203C" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ6</accession>
    <name>A0A4Q9LSZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1623p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001623">
        <property type="protein sequence ID" value="TBU10660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1623p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="458" mass="49739" checksum="FFD04A2E69EF1EE7" modified="2019-07-31" version="1" fragment="single">MKKNIKEEKKRKISYSGMGGDSMGDSGSMGDSGSMGDSDSGNTNTNTNTNTNTNINTNTNTVSTNINTNINTNTNNVDDSDFLTDSSLLEEMVFSKEEVLNKEESKGCVWVDSDDSDYGGYGGDVGCGGYSDKGDDYRGVIKSSNEQDPVIDNTSSLNTIIDNTSSLHPIKISTNSLHPIKISTNSLHPVIDNTIQHPVNNNTIQHPVNNNNIQHPVNTSCIRGSLEGLIYKENKVIYSCVRKYKVNNRVKCVSVEGGVICVVDVLNNVYLGNIKGELKGVNISNYKVVDMCMLKGVILLVSNNSVIKEIRYVTKGVSGLEGSDSMLEGGINKGSDIKGVSNKGSDIKGVNNSNSNYTPVNKLSNEQQGVNMSNSNYNHVNKLSNEQQGVNKSNSNYNPVNKLSNEQQGVNNSNSNYNHVNKLSNEQQGVNNSNSNYNHVNKLSNKQQGVNNSNSNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT87</accession>
    <name>A0A4Q9LT87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1564p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001564">
        <property type="protein sequence ID" value="TBU10760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1564p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15507" checksum="4ABD7529D2CF04C9" modified="2019-07-31" version="1">MTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPLLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEKIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA5</accession>
    <name>A0A4Q9LTA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1553p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001553">
        <property type="protein sequence ID" value="TBU10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1553p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="12754" checksum="D3489D1E9349A670" modified="2019-07-31" version="1">MLDTSEINIILSLLTLTLLIISIYFSVFIFATDIPNILLITDNSTLIFYFLCLYNIPLFILSVNIIRGVNESVGRIFFDYIKWNFKRYSRMEGDVNNIGDCKGVNYKSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU59</accession>
    <name>A0A4Q9LU59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit of 20S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0870p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000870">
        <property type="protein sequence ID" value="TBU12169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU59"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0870p0050"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="229" mass="25534" checksum="D243199B8723F8AB" modified="2019-07-31" version="1">MSSITDYNYVSVFTPEGKVKPLDYIKKTVELGNVSIALKNNECGVMIGYKGQLNDISYYNKKVYKINDSSLFTFSGITNDGLEIVDYLIKKSVSEEVIRDRNISHLSVFDDLCVEASFRTMYSGTRLYGVSGLLMTQSDGIRLIEFEPTGRIREAHAMSIGNRSQSARTILESEVNSLNELDLEGLIRVGIAALKNAHPESGALNQENVDIFCLKDGKTFSVEAEKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF4</accession>
    <name>A0A4Q9LUF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0819p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000819">
        <property type="protein sequence ID" value="TBU12283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0819p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="347" mass="42067" checksum="443239D84B8A5F59" modified="2019-07-31" version="1">MFIRNEDKQYDTCIIRSIEKIGLKFEIFENFYAVNSNIEIFFCHHIKKSEVLLFYEFLISYYFPHYKMTIDMLYTILWFLEYFRAKEIHIMVINKVSFHFSKQDYFSHVLYKKISQEYCKIIKFDMNSVISYSTNENLSYFFIYCKGLYANDKKHILIINDKLNLFLERYKIFTYTESKQKEFDDFDDILFYMGSIYDETIRSINNNINFVDLKNIILIKSQIKTSLSFHHNLSKINGFIFYENTFSDKGYEVFRIKDLKNIDIGENIIQNIKHPFQKFSKVKINEVLKFICDGFAFSCFYEYNGYFNNISINLSKLNFRKFTIKGTIFEKDIKEIEIAIRQYLRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF5</accession>
    <name>A0A4Q9LUF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0959p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000959">
        <property type="protein sequence ID" value="TBU11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0959p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20314" checksum="F46E270FB9992D6D" modified="2019-07-31" version="1">MKQRSTISKIEMYSEHTRSMWQHCNKPGKLVDHLTTRCEKMLGIAYTRRHNAVLLLKINLTNVETKKLRKYGLLANELGLIYRFGKYIQSILLMKTVETISFDRRRGLESGLNAEESWERASTGIIKKSENMKNQILQCSKHLKTKNITSLFSKRGTPCEESAINIRKNKVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUT2</accession>
    <name>A0A4Q9LUT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subunit beta of transcription initiation factor IIF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1254p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001254">
        <property type="protein sequence ID" value="TBU11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1254p0020"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="7">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="22604" checksum="B5C907DEEFD612E1" modified="2019-07-31" version="1" fragment="single">MRLETKNSEITVWLVKVPNFLAERLHELEGDIDIGELEITSATENEPASVNIKFSEKVCGSGFPTSFHLDRSEVDKQMYMLKSEKDTSGIEGKVTTECFVRPVINEEYILYRKTRNEITSGPKRMTQVIDFNKDGRIGERIGSISELETMARKRKKMLMDKKRERLDKSHVMDMLFNAFEKHKFWTVKDLADFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV02</accession>
    <name>A0A4Q9LV02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0856p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000856">
        <property type="protein sequence ID" value="TBU12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV02"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0856p0040"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="300" mass="34628" checksum="8E449314958E8427" modified="2019-07-31" version="1">MLCFRCNLPAQLIRSKDLSKVCKKCFINIFEEEIHQTILESKMFVSGEKICVAVSGGKDSTVLLHVINILNERHSYNIDLLLLSADEGIKNYREFSLEKVYEAQKDTNLEMKVVEYKKEFGYTMDEIVKKVGVRNSCTYCGMLRRQALNIGSADLETKKILMGHNADDLAETVLMNILRGDTNKLRRCTNIILSGTLNTPFRCRPLKYAYEKEIVMYAFYKKLNYFSEECTYAKESFRGEVRVFLKELEKIRPSIYLDLIRTGEYFEKSVDTVKSCCTVCGDTSNVSICKRCVWVETIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD8</accession>
    <name>A0A4Q9LVD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0678p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000678">
        <property type="protein sequence ID" value="TBU12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0678p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26240" checksum="82CB132F6D6D6F3D" modified="2019-07-31" version="1">MSDTSNYVSFWRTKKFRIAAITVSGLIVMIFVILGIGYNKATSIIKDFEIDLKKVSESERFKKCVSQFKKTKTSAFGLEDESSCFVILPSFDISGIANILFDGFEEMKAGKVLGSTSLFVSETDLSKFPKVVGNVNFLTKIGFWFKGKHAIKAVYELSNYIYKELKNNKKNKSILVEIITEKESVLSSIEYDEKSKGSSKKILFEPLKIENDSFNVSEFIIFIAEKVRNSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVJ4</accession>
    <name>A0A4Q9LVJ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0695p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000695">
        <property type="protein sequence ID" value="TBU12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0695p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="818" mass="94971" checksum="E132B28D48D7256F" modified="2019-07-31" version="1">MRKCFKTRIQGIYIVTYIIGVLFLQTNSCASVSGSSLLQFALLNDCWRNKFFEKRELNTVKYWLSSQDGNKFEFCSGTHHFDNKNTHTSNFYTKNDFHCSLGICLYLHEPLNNFESDYSTKWSVKFRVLNNFTFVNLDDRPFILEDYLKVKHHEFRVFVKYLIQQEEICLHSLPYKLFYKFLGIIEVLDPISSKYLNQLYLCLLNKGLLGMDCFKIMSDPNEYKKKYLKQRNHSLMYFFLALDDSLDACLHKDLSCLSLFKKNDQLFDRGFRYIDTMSPINLNISEYIVEYIVKKFNREQLRIFNWLLYSIESTGFSFNKIEMTYVAIKIPCLCDFGTKKLIDIERKQPNLVSSTFFELLSPSNLERISFLKFTNMLPAFESFVSIFKGKHLKYFEISECSGLKPHVISSLIWRNTTLEFLKLKEITLCDKDMAAILHLGLKTLNLNNCGVESDFNHDTIYNNLKNYKILTSLTSLDISCSKLPGELVRFLLKSQNIKYLDISSFELIPRARYKETFSGANIKWLSLKINNCSSNRFINHLAKSSESTECLVLSQAPSEDLLKFFFGLSNFLDTVTSLDISENTLSIEILNLLRGFKRIARLNVANSLPHSVKGLDEMSLFKTVEHLKVSGNKIGLNSDNFVARFYNLTKLDLSGANLQNGALIEIFDDDMLDSLIHLDLSNVNVPIKDFKKLCECKSLKCLYIDLKKVSSVSEYLEILQDANFKERLNFFCVETLEINILVFFKLISFPGLAKFRLVCEKFEETVENLQISNVIYRKILRIEIVYIQPLPYTIQSILGKAFQNYYISIVDNLSVCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ9</accession>
    <name>A0A4Q9LVQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1076p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001076">
        <property type="protein sequence ID" value="TBU11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1076p0030"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Upf1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="346"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="781" mass="87875" checksum="DD997396ED4104D5" modified="2019-07-31" version="1">MKCLYCSQTDYMYKCGTCKKCFCNNPCSPITHIYHHIVSTKHLNVEMVKCHKCQSNDIFRLYVKNSDILYILCDGCVDGEDGYKQVVFDNRLNVGKEEGGACMENAHKQGITGSRSNAGKEVGDENLNRNKNVYSDGKLSEGGYKKKEMQLKFTEEEYISFFTKLQEKILKESLKQNGIKIEFKKENERLFGTFVIPQRDSRVSVGDELYIVSEVDSGKSGERVSSRAFVHSLSKYSEEIIVEVFSQKVVSFEKFSVEFIVKNVGYDRMTNAIKKIFSKCSKEIVDIIMGNNIEEITNKKINEKCINNFVNNIQDIAKVDKCMNKNEEVLTPPNFPALNQTQLNAVAKALSSPLTLIQGPPGTGKTITTAVITYNLIKRDKGRILVVAPSNTAVENLTEKISKTGLKVVRVVSKSMEGVVEDKECLTLHEQIKRITQNKNPNSSNHTVELQNDHQNSHDRKKMMDLEIKLLKMADVVTCTCVTAGRKPLSFLKFTTVIVDEAVQATEPLTLIGCTMGCQKLVLVGDHKQLGPTILDIEASKLGLRISLFERLIKLNLIPELLAIQYRMHPIMCGSVSSYFYNGMLFNCYSGGGKIISILPLPCFFLCVYGKEEVSESGLSYLNREESVRVGGIVRKLLQCGVQGQEIGVITMYEGQRVLISKMFCNEGEEFSKVEVANVDAYQGREKDYIVFSCVRSNDTNTVGFVGDKRRMNVGLTRAKHGLVIIGNPFTLSGCKHWEWLLKWFVDKRMVYEGAVSDLRRGVLFKKGVFDLRAVSESIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS1</accession>
    <name>A0A4Q9LVS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0621p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000621">
        <property type="protein sequence ID" value="TBU12808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0621p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18505" checksum="103F720B40400651" modified="2019-07-31" version="1" fragment="single">QEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLKIYDLLPMIWVLFINGIVTKYHKLHLKRLEIPINTVETISFDRRRVLESGLNAEESWARASMEKREEDAPLISQGGTTLEEPTNNKNKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ5</accession>
    <name>A0A4Q9LVZ5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0594p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000594">
        <property type="protein sequence ID" value="TBU12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0594p0020"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="195"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="302" mass="35411" checksum="3301569802525C87" modified="2019-07-31" version="1">MTKKDFPSKYIYGLYSKFSRNISQTPMKINGKLLYEKSISDFCKSIAEHFKAKNVKFISCGREDANVRMVGKRPFLLEIEGGVYNEEKMNINLDKNIKIFDLVWMKDEIKFIIKNAEMNHYKVYRAMLFIKNLNIHNVESNIPPINLENDNQFSYNKAILNMKEKVETFAANNENHISDEINSFIHSNENIVDFKQNILEIQQKTPLRVVHRRSNIFRTKYIELIKLEKLKNGFLIIDLISSAGAYIKEFVNGDFGRTKPSLSDFFNNYTDLVELDVLAVEECKIPEEFKLMNVFYECVFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW91</accession>
    <name>A0A4Q9LW91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0562p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000562">
        <property type="protein sequence ID" value="TBU12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW91"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0562p0030"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="22882" checksum="BA39210DA67E3268" modified="2019-07-31" version="1">MDPYKVLRIEKGSDITVIKKAYKKLVLKYHPDRPNGDENKYLEIREAFEYLSKDTVESETINVENIINSYKNGPEEKEEIKYLYMKYKGDMCKIIDNMIIGEDTDETRVRIIIDELISNKDIVKYKKYCKKITSNKRRMKKKEKEAKEAEIWAKEQKIDLNESLESYFNRKNQERKAFLENLEEKYLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW97</accession>
    <name>A0A4Q9LW97_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0583p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000583">
        <property type="protein sequence ID" value="TBU12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW97"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0583p0020"/>
    <dbReference type="OrthoDB" id="2193051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="33780" checksum="C931041B00E0874F" modified="2019-07-31" version="1">MGTNRTNIYKKSNKRIYKWLINTFILFVLIIFQLTFILFVFQDKFIYKIRKDDFTISEYTETKYLESKDNNLQLYYINNNSDTDIYVFHGSLVSLKVHQLICKKMCGKKYNLITFFYRGYNKNRGKCNEVNIMIDTYVLYKYVSMCRSKNKKIIFGQSLGCASALYFASLFDKKTDLKIILENPFYDMQSITKNSWFFKIPSFILHEDWPNHLRINNLININLKILFIVSEKDIIVDNKDSYKLMEINKKIKTDIYVLKGATHFDCGKFKEFFITVDNFISKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB2</accession>
    <name>A0A4Q9LWB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0556p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000556">
        <property type="protein sequence ID" value="TBU13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0556p0010"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="167"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="36201" checksum="8B425A856CB113A2" modified="2019-07-31" version="1">MTILEYKIYVKNKENTEKMLSYSVTNNMKILLIIQFDCEKHHIIRKYYRLIFLLKKKNKSKSVIFIGFDENKETDKLKLLDISNIEDYINYNISEYYNSECEDDECEDNSTANYIDYKYDAATVNIDKTDANNITSCDTTNIFESNIFRNANIDCKLYNDEKYSSVIVGGTFDRIHEGHFLLLSTAFLLVKEKLTIGLTTEVLHMKKAYKEIIQTYKERKEIVIFFCKIFGIKKAVISPLSDFIGLTDKENFDCVVVSEETYKVSLILNEIRRRKNLALMKIVVTPMISTKTYRISSSELRRKELSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN8</accession>
    <name>A0A4Q9LWN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0514p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000514">
        <property type="protein sequence ID" value="TBU13158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0514p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21689" checksum="DA1AF4AA7141D0DA" modified="2019-07-31" version="1">MMVNSAANIYKTLKYKSVSKLEYLKIKMNENITTCLPILFAFSHLFDISNLNILVLQCVKLDVNDASVISNLKNLKELHIGVYQQKNEMFLNLLNKILENKKIIRLGLDIRNLNLNIFEYCCNFRKIQLVFIRFKNIEAYDLTLLHKMKLNYPNNVAFFCEYYSLVSVEVINFCEEHNIDFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ0</accession>
    <name>A0A4Q9LWQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0908p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000908">
        <property type="protein sequence ID" value="TBU12080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0908p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="958" mass="114797" checksum="B1888421E9FC57B3" modified="2019-07-31" version="1" fragment="single">MTKRETYNLIQSIIDKCLKNKASNNSFDSNNDPFLLSKMNKTSITYWFRLLNYFTVQIKNFKSEFFVDKIQVREFSESIRPKIIFVLKMLVYILRNTFNHELYVIDPNISIYLYSNDLDVAYHSYLYYSEYIVHEIALMNHDSYNNILDIDFSLYETKRYIFDESFKDGDSDVRYEFIDQEFNEIMAEIHKIMEDMKSKGKVLNFYKIKEEIEVFSIKHADILRFECYKTNQMEILLAIEILANSINHKIFKKTNFDSFILSIKYFFKRENLYLSESMIIYQSCALGIFSTEENFAPENKYVKFLLSTNIDDRLLESESLNECYAHSKKFLKIFLLFFNRHLKFELEYLFSRDIDFKKISFSDMSIFLPFILNNSTVFELYLLSIDFEQLCSLVTSFHEVLTFTCENFDQTLSLLRSINIYEETVLYWVKFFRKTQFYISSENNFSIFFILKDTECIQNIFIGIIENNVLPEHLRDKIFAYVFTNLEEEAKLNLTNSMKYLKNMYDHFISDNLVVSIVTIKNMLSFCDLIVRKQLVTQFPFILEHIAKFYATHIELSLILYNFYSYHEYLKSHISSIVNSFESINFDLKPFEKYVINKDTQQIEVFKNFNFIKRIQSWDKFSIKLYEYLRRHGKNFCIEFMIYHDFFLKNLLELIDHILTFKNITIAYFNINQLSFFLKRDNDLFLSKNILLIWNISIKICEKLELDFLDFFFTQFIDLFDKNAIKSSKNENLKFSWNDEYDSFCFLYTVCVSFQFLHDSIIYDLKYAKIGTNNYKLIQLIEKGYFCVYKRENYLILQEESNIISKEIIDRKIKNIRESGGEIENILGKTSYLYILIAISKIPLNLVYPPSITNPFKILFLHLIYNILNMNMEYDENLIYVLYLNILEFKSAIIFNDLNEYIRILDILLIKTINFNSKTNIDIKNSIDIFFEILFNLMNKLNNKNGTEALDGFELIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX00</accession>
    <name>A0A4Q9LX00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0501p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000501">
        <property type="protein sequence ID" value="TBU13214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0501p0040"/>
    <dbReference type="OrthoDB" id="2194637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="686" mass="79806" checksum="C4A5CF27E0C87D10" modified="2019-07-31" version="1" fragment="single">MSKDKSMGDRVSKSMCKDNTKSMSKDKSMGDRVSKSMCKDNTKSMSKDKSMGDRVSKSMCKDNTKSMSKDKSMGDRVSKSMCKDNTKSMSKDKSMGDRVSKSMSKNKDKNKDNTMCKNKDNIMCKNKDKNKDNPIDKSITYTSDNTIDNYICNTIDNYRDKSINNSKDSLKCKMYVNEFEMKGEELYYNKGYYNNYYKDEGLKYNSSSSYKDEGLKYNNSSSYTDEGLKYNSSSSYKDEGLKYNSSSSYKDEGLKYNSSYYISSSYISSNSIKYNYLSTTDTSNKDTNTNNKYSNNKYSNNKYSNNKDTSNTSITNNKYSNNKYSNNKDIIPRYLNSSSDSYKDSCGSSFCSEQDYNYFMHKNNFELNRFYFYANSSSSSRDSINRDSINRDINKKSINKKSINKGINKKSINKKSINNNPIYKKSINNYYNDNELCNSGYKNNNNYKECNNYDRNNLYDRNNNCKNLLKKNNTYTNTNTYTKPYTNTNTNVNTTYNNTYTNTTNTNTKPYTNTNTNNKINTYTTNTNTYTNNKINTTNTINQFFVKNDFLKYKLIDCVIGLYYKIIKNDINRGVICLMNYFKCYLPFTLLIGFIYLKRYLIRVKKRNDFYFFVKLYLVCCLIGNKYWEDSCGGNCNECSVWGFEVEDINMLEKHVLNTLGYDLEISSEEIESVIYYERICEGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX09</accession>
    <name>A0A4Q9LX09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0472p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000472">
        <property type="protein sequence ID" value="TBU13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0472p0030"/>
    <dbReference type="OrthoDB" id="2187331at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="719" mass="85329" checksum="AB1E54913F226277" modified="2019-07-31" version="1">MFAPFSLTPKYQSIIKQIYYKEEGDDQKISLLIHYIKSKPERIKKVFSYLKEKCRKEFEISQSVKITCKIITSVIEELSEYSIYFETEILKIFLIIFGEILQIKSTKTSQVVYSHEFLNLFEYFFKTLQLKTYKSEKYINMIIRIITRELENIEIKAKYNEIDFCSDQNEPLTIKNTGEEYTDVNQYLNSENNSEKYGDSITPTIHTLSHSGSNYSKSSSYEEKYKQSEDIIEYDYNSEESSESSESSTSEISFDYQSAGCVPSKSDVNNDLYFLKFLSAIIITKDFFIANYREKYQNIVNCLFKKDKLNISERNEILSHMARACNILNSSCFIYLVLDYSSRLKLDLINDILLTNLQKATHPHIVIESNQIFMEEIEKVKAINYSLEEIQNIPSVTYQSQLHILLKHSSLLVKEDYISNSNPLRLARSFFYLLKYLYEQETENSLKNEFTLKGSEIVKDLEYFNYSAILEYLNLFFLACFSISDVLCFFMKKAFQFEFYERNSLMTIYTRRFQKMILDRILFYFETKTKFCSPIVRIDIDFISILSRISTIPCFNVLCTKIFFIVLKNNFLSCGRKDKQMVLSKMRVVYYESKYEEALEILIQSILERVNKKDEINVRQSLEMETDEFTTWCMLNTLKENLKIYIFRIWNCKEIDDPENFILKKYQKEKFDSFDVSVEQKKYNEYFGWNKRVYTNSMKSSINLEGLNAKRKSFIKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX75</accession>
    <name>A0A4Q9LX75_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0476p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000476">
        <property type="protein sequence ID" value="TBU13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX75"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0476p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15451" checksum="075C5C096E81628C" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKGLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXT6</accession>
    <name>A0A4Q9LXT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0377p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000377">
        <property type="protein sequence ID" value="TBU13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0377p0040"/>
    <dbReference type="OrthoDB" id="2191709at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="91516" checksum="B6D12A4644072133" modified="2019-07-31" version="1">MHESKNCLDEVKAVLFSLVASIKVDINKESEFKAILCDINTILKTEPSLYICLVEWKFFTKQFIYILREECIFIESMDILVNALEYFVQSKKKNNLKEFFINRNNLIFLSEKIYKTLKNIKTEFNENFIEEDLLWRCSESKIITKVIHSLKLFISLNDNFTVSILLNILMEIGFFDLILFLRTETVCDFFNQIFKYKSCFKSKETTISDKCTVPYENIRKHFDPEIFYSLKDNIPKKSYFSKYCFISNPVFIKLAKMIYQYVFYFLVEYFSIPRNIHTINFICELKFTGKLEDIENLKYKKLSTSTEQIYDEIESASRINFLNNHDYKENSYFSVVHDNSDNLSENKYSNNETLNLFNYRDFQDHSVHEESMKIEVNSNFENKDISNQNIYDETISQTLINLPDKIDVGLDHLINFNSVLSRITELQNELKSFPKVCYFEIYINMLELIRNHSQKQILIRKVFQNTEFISKISAFITDKNLEISINSVKIIYNHYVLLKEFFDKNLFLYRGNSKLEKNNIKDLFRCLNKEKKIQRMFTLLQYSCKCVSGCNYGNCIYPRVLIVLGNTFLNGKKEFFYKPSNLALMWSIHNFFPEFADEKIVTFDLSNFSCFFKIYFEKFMNFLSKNPYNYAKILFPIENKKIEKKEAKFNVQIDQDEAEFNIKNNDLISSSEEEQTLEPYNSKSKIFDNNFFESVIFKEEKNELKPEEELEKSTEKDLQNEIMDQKNTKNNFTSTNFESKQEIEESKINSKKKKIKKSKYNLESSSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW8</accession>
    <name>A0A4Q9LXW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polysaccharide deacetylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0367p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000367">
        <property type="protein sequence ID" value="TBU13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0367p0040"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020944823" evidence="3">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="28828" checksum="F6A1C46A47A9F939" modified="2019-07-31" version="1">MFFLKIISYIFAASLPDKCVDSGVICITFDDGPTGYTGEVLDMLEENNIKATFHFTVQNITRGNISGMMRRAIDEGHCVGIRLNPKRDYDQMEADDIKSDIDNQVKVMEGELDRKIKFARAPVNDGEVNADVYNALLEKGITQTNYSYCFYYEADDSEDATRQLKMVLNASNPKYESFIFLLHDEKERDFPMLEDIIKYGKEKGYSFVTMDECLKGYDPKDMEKGRKGSRLSDSSGVDKLLMVPLCLLIFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY41</accession>
    <name>A0A4Q9LY41_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0604p0010</name>
        <name evidence="4" type="ORF">CWI38_0610p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000604">
        <property type="protein sequence ID" value="TBU01897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000610">
        <property type="protein sequence ID" value="TBU12831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY41"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0604p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0610p0030"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="435" mass="51189" checksum="BD8ADA62208CCCE4" modified="2019-07-31" version="1">MILCCKCGTQIEPRNLNMCDFCRATEMSTTDFKKDDMIECCRSCSRYLYNKSWYSAEWHSKELLDILLKKVSSKYEINDAHFLYTEPHSKRILIKIIYTNQNIEHPIEIKFVIKNKQCTDCQRIEAKQFWNCIVQVRQKVEHKKTFLYLEHILLENNIIGGEITNIKDRKDGVDFYFLDRAEAVKFFNFVKESVCCRTKTSERLISRDLNSNKSNYKYSFSIEIVPVCKDDIIFISERLSKILSVDRYLLVTKVSTRIFCLDIKNLKVVEFTDKFYWQNEKEICVVFSSKSLRKFIVSEVEGVSKKAYSKEVEGSDIYSQKLSNQTQLCCYDVYVTTDYTTSVHCKTHLYLKEGDYVLGYDFGHANISNVEECDFQIILVKRFFEKSKNKKTNKFYRNRNAVSFNEESEFSSHGKNSGEYDEEEDILADLTGLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY49</accession>
    <name>A0A4Q9LY49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Spc7 kinetochore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0346p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000346">
        <property type="protein sequence ID" value="TBU13748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0346p0030"/>
    <dbReference type="OrthoDB" id="2195102at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="646" mass="77696" checksum="39B32ABCC651D008" modified="2019-07-31" version="1">MERKESQEKRKRVSFAPEASINFYANEVQQNTKSTSSNEDLSILNENEESLSLTCAAIPTSDDGYNFYSKIEEEKENKNFEEKFNEEGNFMEIKSSFEKIGENNDELNKSIEKIVDDAIRYNIPLNEINIFGESIEKIIEKEKIIEKEDQEDLKMNTKDFSFLNNNFMTETINMREIIDTQDLRKFIPENKNEKINFNDLLVSHGIRFLDKMIYNRGRRSTISKSKNVVTPNLKNYYKFFKINQINFYENFIFDLERLNEEQEKTNENLENEFKIKGSLLEDEDKDKHLKMLKSVCRSTAKVKWYEIRKKYALEFYEKIINEKNFLSEKLNRFKRENDNYLSKINSIKEKIEKMEFENNNLQKKIEKYSKTDILEVTNLQNTIKEQNMVHERIKKNLEGLEENMTMKRNKYLSLESQVCILRKEVEEISTRIKSMNITEQQMLEVRDSFKIFSKIFNIQIIKLNSNFFQFEIGFFEFYFYFSTEKENIFLKEINIHLKKNEKSYKSNTIPLIYQFFTEKTKKNLQNFNSFNEILNLKNKNKNTNWIEEIRNSFLFSYKIKNICKEILQIESHFEINSKITYNKLFIDVEVINLKKVKKYTIRFEVLGFDLITFTILDTENFHIDIFPTNFYFYTVTRKISEIIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY85</accession>
    <name>A0A4Q9LY85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0484p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000484">
        <property type="protein sequence ID" value="TBU13267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0484p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="784" mass="92257" checksum="72156E4A6C988D4D" modified="2019-07-31" version="1">MRVFLALYYLSSPFTIKCKREIENEELCSTRNSVEIENITLPIIRETEEEEQQYINFIITNSYQDIIDNFSLSYPLIEKFFKPYLAIIKDLYEECLKDSIKAVTNSDELRYTNMSRKELFIALYQTYIEKFTGKYVQACKNSKDSRYYSSDFHKKEMSKVSYFSNDRVKNIFNSLKFPPNSENKIETHEEIIKTIDDITKENLFKQFTLKMTCKACRNVLIECVAKNRKVIYLEKNKFPIISTENFEPMIDDEVKRNKFLKYLKAKYAKNEWKFPLYYTDQYIKMHSTIEIENYYIKGLLQNFFFENFGDFYKFEMMTVLMHYDTFDDNRLGYFQSISERLKHKCVIFETNFVNDIPNFLRKFLQSCESLYEFESHRIIYLTLFLKIDDWLEVFIEDFVKILGEDKFKDVLMISFSNNKSSLITILEEIYVNRALPRPFCNEIDSIFDAIKNNIRLRTKISVHFHKVRDSIVNKILGVFCEEKQFDEDMIVYIESDDRYFEAEVYGGEVSKYKVNIGNMEGSVSKGKINRSKDKDGRGSNKGKGKDNTFLNFNIINNTPLNIYANNKPPLVNTTDIYTFLVNSTDDNTPLITLPIITPFFPTTHIINSPFPSIPYSIDNLEINSNICYNRNNRRDMCDSKNYSIEDTGNNTIDTNTSSTNTTINTSTTTFTNNTNNNNTITKILLKSDDKSEISRYYEDDCSIEDFVNELAVLSKGIIKSFYVEIQSLKNIVMSVVDQILLIRILDMLSDWENIGFRFIRDCLRISYLEKVGYIKGRIKGVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYG2</accession>
    <name>A0A4Q9LYG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0307p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000307">
        <property type="protein sequence ID" value="TBU15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0307p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="276" mass="32640" checksum="52942F3B3C3F2C22" modified="2019-07-31" version="1">MISYTNCISNINVSWITMHLMGRIVYGTRKKGSELTKEWEEDLKKSLIEAFTPDCMSNFVNPSMQPKTKNFRFITTNSLQDFFDFYFIVEPGFRLVKESIFDTIDFLNADKFIEDVNKQTKEYLLKEKIKRDEFVDKVISKFSSLVIEKLKCLLENKFSKAKQCDDNNSMILNDSYKVLAQEMNKLCDKFKAENKKELAKAVEDNKKEANVLNIIEVIKSRFFLLYCGEIFISKFYQLLYIKSKKDLYFNFFGKTKDECIAEEKEKNNVYKRLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP4</accession>
    <name>A0A4Q9LYP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0436p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000436">
        <property type="protein sequence ID" value="TBU13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0436p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8280" checksum="E13C764D61D554E6" modified="2019-07-31" version="1">MNSILDKTKCEESWESASIDVIGGAEISKCKKYFTTYFKKRISLDEPKINIKKDSDLEEEYLMFEGAKGCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS9</accession>
    <name>A0A4Q9LYS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0534p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000534">
        <property type="protein sequence ID" value="TBU13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0534p0030"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="17659" checksum="4BB276019B521FEF" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSPYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC1</accession>
    <name>A0A4Q9LZC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0342p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000342">
        <property type="protein sequence ID" value="TBU13766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0342p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9895" checksum="2F5851813383905D" modified="2019-07-31" version="1">MKIQKEVIFIVTVFIGIIFICGLSGYFLFRKTTKEEPTLKNDKISTTKKRSIDKTENESTKKEVNDEKSNPYDENHNTRYIKSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT3</accession>
    <name>A0A4Q9LZT3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0200p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000200">
        <property type="protein sequence ID" value="TBU19795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0200p0020"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="22814" checksum="CF1540C3D6932ADA" modified="2019-07-31" version="1">MDNKKAPTVKIIVIDEADAVLNLDSSMGSNAYVILKILEKSQKIYFSATFYPQIKKVIADYSPKAICIKKMKAIKSSYEYLRVGQSIIFVATKHMVEVLRKELGADLHEKACLHGDIKRQHKKKLEHDFRTAKALTLISTNKFLRGMDISQVNLIINFDLPIVKGIPKVETYIHRVGRSGRFDRSGVRVDLVNDSNDFNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU5</accession>
    <name>A0A4Q9LZU5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0425p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000425">
        <property type="protein sequence ID" value="TBU13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0425p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="99050" checksum="B5427E0819A7A33D" modified="2019-07-31" version="1">MPRINKISRYCKSDKNRKIKNETEKHHFSEYQGSIKLITLLILFQSLFKPCNCFRIEVMFPNEEGKRQSIRKDNTPYVLQTIGENQLIPSTSNQAFSNTTKNTNYIQEVNIVDIDQEFDKSKQTEHTAKRKFDDNIIPSGSCLSAEIHSDFDDSQPLDLSCKKKIKSSQIIEDKDSEWLKKSNTSISFDYSDKFIIQSRYFNNFRESKPDDHKFNISEITSTNIDIQTFEILLYVLHFGYHKKCLDLKTKNFINFLEAFTYLSCYTNSSVMYTLYKNLTPLLVSYMNYVKLKLPDETVKNTLFKNSMLFLPFLSTIFRTVDVKFDKNTDELLFSKKSNQFEIFFFDTKTIQKLIIRATFDALILITNEPNIDTKLFSELIHLYIINTVKISHDNIYYSEAYENDKNYISKKLPREEVHSNLNIFSFDVLKDIFLTTKYDTKFLELERIALSFYDLNLFTSFRNLESLSLVNCIWPTNIHFFSKLYFNFPRLRILKLVGFKLNEVFFKNLIKIKIEYLDLIDCYYKCCNDKLIIWDDDNTLRGLRIDYSKLGNECTNFLIKSKNLEYISLRHIKFPCNKSGSFLLGRKNFTSLELSGFNILEYISNFFYVDIEVENLSLTDMSSIELKCILKQKTLHTSTKSLDLSGCPLDSVEIDFLKQFEKLEALKLCNLPSLEQSLTGIDFSFTNTLLSIDLSNSKFFQNDLMFLCQFNCLKELKIANCDFKPGFMRFIEFGFSCSSLQKLDISENQLDIHDIYSLSLLKNLNYLSITLDDRIYMQFVARYGNISFSKLSTLVLLSTSTTKIPIKFITAQLSLINLHFINLTINDGILSVEDISCLKYLKNIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M079</accession>
    <name>A0A4Q9M079_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0422p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000422">
        <property type="protein sequence ID" value="TBU13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M079"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0422p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="20967" checksum="33E1E41A5C48735B" modified="2019-07-31" version="1" fragment="single">LQIVETEKLRKYDLLANELGLIYKCSVGIIPYVMTWDGIVTKYHKSHLKRLEIPTNVEAYIQSLVLKKTVETISFDRRRGLESGLNAEQSWERASMGVIMRAEMHEEPKPPLKQASNEEGCEPINNIKGRVVFGRRDSSGERGRIKHIKMGKKILTKNFIHGLLYYYIDCNNYDIDRKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M082</accession>
    <name>A0A4Q9M082_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0707p0010</name>
        <name evidence="2" type="ORF">CWI38_0148p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000707">
        <property type="protein sequence ID" value="TBU01452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M082"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0707p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="190" mass="22255" checksum="2EF9CE9985A1874B" modified="2019-07-31" version="1">MILYKKDYNDLVVKNIKNSNFISSEQIKNVIIKIFINDGEKIYSIETENKCSCYICSDTENKIYTLDLSKSFFDFLVPIKILTVKFVYHDAFVKRNAGDIVSILPDSCKCEDLKNLRVKFLIDDTLDLSHYIGILKHDMENIGILVYSESLGFYSYFKDIMKEIPIECEFTKENYFEYDLFNVLFSAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C2</accession>
    <name>A0A4Q9M0C2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsJ-like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0239p0020</name>
        <name evidence="8" type="ORF">CWI38_1093p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001093">
        <property type="protein sequence ID" value="TBU11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000239">
        <property type="protein sequence ID" value="TBU18506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0C2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0239p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1093p0010"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="31254" checksum="581E9905ABAD7BC3" modified="2019-07-31" version="1">MTLKSKEKRDYYYKLAKEQNYRARSAYKLLQIDQEINIIKKCKNILDLCAAPGSWSQVVLERRNNEETKVVAIDVLEMFPLDGAIMLKEDITSELCVQRIQNIMNGEKFDLVLCDGASDSTGFHFKDEFVQNELLLSSLRLSLRTGKVGSSFLGKCFRSENFCKIIKIFYEFYENVKLFKPISSRAASIECFIYGEGLKRVDNCSLSFNLFDFNLDFSEMQKYFLQIQACGTGPDPDISTNDNKAYKESKYKPIDPPYKPSIQIRRNNSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G9</accession>
    <name>A0A4Q9M0G9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0360p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000360">
        <property type="protein sequence ID" value="TBU13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0360p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="235" mass="25745" checksum="8526E4DAB42664EC" modified="2019-07-31" version="1">MIISFEINPVVEVLKYSTVEGTDGEENGGPAKDLEHSGNANYTSCTRSKVSEMDGTNIFIDGNPNRSEDEIGVITTDVKPSYFLLQIGNGTMQQEPGTEVGSDSKADSMNSSDKICGCCGKKRICRINCYCCRSRGSSKPSECCTDSAFITHCTDEVVSCFRTCSDDVIKTIECCFNYPFKQIRRCCHHHSQCLESYCDDHLTCDDDCCDDCCEILCSPCCCICKCLVAILGSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H3</accession>
    <name>A0A4Q9M0H3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0127p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="742" mass="86563" checksum="E172761A27B0EFCD" modified="2019-07-31" version="1">MVVITFNNILFNHLFGYLNVVWQSELDTSFYLEPNNSAFTGNDGIENYYYQASNYLNQAYSEINPSLCSPSSSLSNRVQTNYLSPYTQENPTNTVAYTAFNDQPNPQTVSSHLYSSDISSQNILPVEKLPRFDLAFCHSKESNQKALHDRNVPNFAPILQNNVLSHQEEYFLPTEQYQIPHENSNNLDSENNVHDSEITNALSSLINFHETFDYKSTISNTEFFNRITNNIDACESLEATYNSQSHKEGLNIRLLKRKKFVATAENTVLLSSREEGYKIKMTCEVHHDNTRKLSMTRCKLLDIILSRQLKSIQEGYNSILKSFIKLKKFERDDEKNDINEIILKNIHELNLDKVFLDNLHAQSYKDLISSNIKHIFYCIFLKNKTFIRETKSHPQHLTYTVQELEQIFSSEIANLKSQDNDASNVLKICSFFVDYEKKLLRDMSISMILEALKLPKISGIFIKFYECLKIDVFYEILVFIERHEKNVEQIIKKNHVVSTIFLLNALAIDLDKKKSISSQGKIWENLHLTSRVRIYADTFYRGQLFESLLRNLEEYETKANCYGMLNTCRFLLNVVTFGKCRKTLLFLQIPCLIAMILNKSFKLDNRQIKEFFAFILLLIKKKKTINSQEKFYNDMIQYFFETNSSIIDHLVRFNIFLIEKYTNAGRKKHLGCIFISKCKNVFESLGALSQNIPQKDLKLKQLYASQLYWIMIFGNRSSIYSNNFRNITNLATNLERKINELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M6</accession>
    <name>A0A4Q9M0M6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0216p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000216">
        <property type="protein sequence ID" value="TBU19278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0M6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0216p0020"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="534"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU19278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="641" mass="76641" checksum="9CB97E0FC23E44D7" modified="2019-07-31" version="1">MTDNTIPREEKKYKSIYKDLDVKRSLKVIWTNKCKKNEENKYYVSDRSKKSVCIKTKQEMAKKLEENNTFDFSCIHYAADKSDVNFIKENIFNVNLDIFELIMDRLEKEWFFFQQNLVNKVYVPTEYAAHVCNICGKSDSKVGNDTIFCDGCDICVHQECYGLPYIPEGTWLCRLCLFSKKRTPSCKYCTKIGGALKQTADNRWAHILCANWIPSLSFVNTVFLEPIEEIGDELRKYKNSFCIICEQRRGVTIRCTHMNCDISYHVTCGMEANYYFDQANFISYCKNHDPRKILSLFSFGKYRQSLYPDLKNIPDIRPHVLLSLPKPSFIIKVKEMKPILCNHFIDRILSNDLCNIEIETKTVETIGMWWMLKRSFIRRMPLISFLNFEYGSDFGHEWFKNRKLFCYNRFSLDYYKSKGVFYLNDMDLDEEKFEGEIKDKTITDNQDLNCKENESEGFVNSNVKYECQHKAGYEMKEETLKEICDSVVILKELLYNLKEYYHTRSDLTQHNLNLFEMYKNPEKYYMKEFLLKLREVTDFFWFEEPVTEIIAPKYFTIIKNPMDFFTIEKKINEDENYKYKFFLKDLKLIYDNCKIYNKNEVYFQKLLCQFDSVVNELNLKYKEIIYEKISLKSLLEYLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M147</accession>
    <name>A0A4Q9M147_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0339p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000339">
        <property type="protein sequence ID" value="TBU13793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M147"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0339p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="831" mass="99507" checksum="0B83051D905EB91F" modified="2019-07-31" version="1" fragment="single">MCIKSKNIEILEYIGLNQSNVVQSLEFMSKILSILDKFSTEEITIFMTTYEYKDTKIKYKNEEIMSLSEIFRKIPTLKNFTSSETFYEFDINILNDTSKLMTISIDSIEYLSFLRAKIKDRNVEMLCKKYIYSQNIINTTVAIFSIILQINKPLKIYNLEYNKILELICKKCIFDFCMNQPEFRKGIVLFFVKNNLFDISIFKVLKDEFIPFNWFKNVETSNSEDKELQYNDLYSLNYKSKINITKDLEENGIENQDTYSLNYKSKINITKDLEENGIENQDTYFLNSQSKIINNEFIEENDHKTGDLYPPNYKSKIIHKENLNEKNHKSEDLYFLYLKSKIIIKEDINEVIKNKIFSDNILLLIFGKKIDFNLFNSEEYLKYALKWEESEIFEYIFEKYLIFYVKYEIKPKREIYRKKYEIFNEIYKFLNQEIENPPILHKLNYFSLEERNKLLEKYIKLYNINEIIETFFDVEIYSNVLKEYLKLNVYKIAKPINFCIIISRIAYSDVNEDLLMEKITSLTKKEMNKFFTLKISLLPFKKWIFSQETLPKRYIEDFFEEIVDKLDFLESELLKSLNFVSNNFLINIFTVFFKSSFCKSVQASIIIKFLEEINLLKNPHKKFTNFVIESQKYYLNEILTDDFFQKEDIISCKKFLDNIFIYLNFTHNLEISTFYDEILIKLKRWCSYHNEVLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVDKEISTKRAAILKVENNNKSHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L2</accession>
    <name>A0A4Q9M1L2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0185p0040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000185">
        <property type="protein sequence ID" value="TBU19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1L2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0185p0040"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="57452" checksum="464F71B280471626" modified="2019-07-31" version="1" fragment="single">MNNQTDNKKDNKTDNLTLFITLCEILEDISKTKKRLEIQEILSNYFKKINNDSSLLITVLYLCTGRIAPDHYNKEMGIGETTIIKVVSEVTGLKVQKIKQEMSVTGDLGLIGMKKRVSQLFVSKQPKLTVFQVFHTLQSLSEEQGFKSINSKINKMISLISKSNPLETKYLIRLFEGKLKIGLALKTVLISLSQAFSYKRYDVDSASSITSSSITNSVLPITDSHIPHSTPHTYSLNSDCSEEVKFAYNKCPVFEELIPLLIKHGPYQLNNYCKMKCGIPLKPMLAQPHNNINNVYKKLQNTHFTCEYKYDGERAQIHKFDNTFMVFSRNSENLTEKYPDLEVNISKFPYKNFILDTEIVAFDFCNQKILPFQLLSTRKRKEVRVEDIQIEIQVFIFDILFFEDTELLQYPLQHRRNILIKYFSNPNTKFKIVTFKDISDVDSKVDFDLDSKLDNGSKLNGDNLINDKNIINSISKDNNKTEDNNINNDSNINNNITED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R0</accession>
    <name>A0A4Q9M1R0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0038p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000038">
        <property type="protein sequence ID" value="TBU20664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0038p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6793" checksum="21F412F3F13914D6" modified="2019-07-31" version="1">MKSTSVLDCLERLNNSDRDRKFEMKNHTRVNIELIKSEISLNYDFMILEEGNIRKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1T3</accession>
    <name>A0A4Q9M1T3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0034p0060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1T3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="26001" checksum="2FEB7599261AE437" modified="2019-07-31" version="1">MKDTKHTSLFPKSISQKIQHKLTTSPTKYSFPTLNSLLQYSSTLTSIGSFIYDDVHPFLICLYFLHRFKPSKETILCLLKIKQMMESKECGNYTSNNKDKDDNGDKGIIDRSNINVYNTYTSLDTPKTSPYISPVNKYTLILLLFYIKLSNQPININIFLNDYRKITVINCSNKKDVKYLDEIVYELLTEDWSMIKVFTYRRLMGVKQIEYDKGRGVIYNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X3</accession>
    <name>A0A4Q9M1X3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0162p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="644" mass="76132" checksum="7E10DFB500170E5B" modified="2019-07-31" version="1">MHIFFSNAEASPIPKKCKKSDSRHVEFEHPNQKNRKNNPNHCDVGNIFSLAAKDIKLFQKNDSLKRSNKRKEVNDRTKGDPEQIEEEKSTAISQIPFIQINNLFAKNPEINFEHKASEVFSFGDEPLNNVQSFPQTKLPSFKTVFPKQFYDYENLESTKIESRTQSTSEKQIFYFDISIRSENSVLENIKEHSFDDETPCINEAQGFCSEIENKDSEPNGEIESDFDKNNSSLQVNHTQRKHDQGMDFSNLYDSRWPYNNIKTQNRDIVIKKFVIEMTNKVSNTLQNELSLIIQEELGGKLNKQDNSTGVDLGEPEILSNLQKENERFFTKELKTNEDFEEIVEHGKRLVKFEANSYLNPRTSDEMQKAQGFNLINYSHELKNTKIHFIVPEIKYLLNSFEKNDNSIILKGHALLVDYYCKIIKILANLIFENNINANKNKTKEENNEAKILMNRRIFFLRKLLAELYILFQNEFNKVEIYRILNMINYFSTLVRNNRSYFRKLPCMLKLRYIFRFLFDPDSKPNNNFLAELIQDINNIYTENKTENLEMFFQKKLTDLFYNYYCLPIYYEKVLTIINGYKIYPNIRNILDRETKKIKDLHKQTCMNSTAENAEAYLNVKLEEFMELERTLSYLEKKYCRKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B6</accession>
    <name>A0A4Q9M2B6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0127p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="591" mass="69175" checksum="A19DCEB30CABFE4F" modified="2019-07-31" version="1">MNNRMLRQKIWQHLVFINSWIFSANFDYVTDEKTGNSSSIAENHVANNTKIDIYTNHSIDNILSTHINVHLTDNNYHDSGCPRYTISNRFHPYFLPQSISETPISSHGYQRNVKTHFISPNTLACSSTDERDPNRMYSTYYNKNFNCQKQNFKVPNKHPQPIEDISFVHSISKNITGNMLYDIPSIQNESSMISSTATKDECFHSMPIPPLQDNMDSRKKMLDVNVCEGKISLVEPGKNISITSDFGCYKEQNNQGIILKGRTPDIIDDTNINQNISDMLRNGKTIEEIWSDLATKPREYIATSDNSKISRTKVDFDKKKNIVNYFSNYFIEFSMTQFQKISKYLFIELRAMQRDYENVFKFLVDAERLNSTEKEKYVRDNILSGIIESKGKKKFLPKEKIPEFVELIFSSINPIIQNKLLNKDASISQSKLHSKHLKYSIYELENMFSAEIRNLETQDIDISNIINLCSFFVEYEKTLFGDMNISTIIEVLRIPRLNETLSKLKECLNKNMIYEIYMFLELYEQNLVCYIRKHHVISTIFIIKTLYIHINRINYTDFFRALYKDVYSKQRFTLATQIFGAGRLFERLLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D0</accession>
    <name>A0A4Q9M2D0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0088p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9196" checksum="BB049A92264E3BB7" modified="2019-07-31" version="1">MFVGMCVSVGESNISTRISRSNLKIISNLSNRISRRDEINNDYISNNDTRIYNVNSRYNVNSRYDDNSRYDNSRYINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D6</accession>
    <name>A0A4Q9M2D6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0214p0070</name>
        <name evidence="2" type="ORF">CWI38_0220p0050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0050"/>
    <dbReference type="OrthoDB" id="2192887at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="24836" checksum="8FAE276DB273E87F" modified="2019-07-31" version="1">MSTRGYKNVRIFTQLLTLILILVNTALLVIFFVHKKYFTVEEKINSSLINLEFVYKYTAMLNITLGFFASCCVNSKIKMYMKIYLLTGFFLLAMHLGFLLYTKLEYKNDFSQQFSLQMAQNPSVKYLVMTLLDCTEFGENNCMDKTKSLSSLMIHLYCFITVISFIDNLLLFVMIRVALSMDIAVPLPLPPKIESNVPAGFSTESLRARRVIKEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M3</accession>
    <name>A0A4Q9M2M3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0001p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="784" mass="93379" checksum="0ACD9C632853AFE6" modified="2019-07-31" version="1">MNFKLSLRCIDLFYCLLNFYILLFMSYSAERDVTFNVLSSHEELCSSSSVVDTDFECLCRLKRDSVCIKKEVEYIQKLLIRDENKNYIKYVIKDLEKINLNFILFTKLNDNNSNIEIFLCNHIKNSEFIIFYEFLKSNALPDEKMTVDRFYTILYFLEYFRVEYDDRLRNILRLSLSNLEKSTDIENLDIEKISFHFTKQEYFSRKLFKKISQEYFRMLESENEVDISFLKIRKSNSYQRYEGLYTDDREHILIIDETLDRFLSEKVNMNETKKNLFILVLNTLDIKYLHIPNLKESVHKTCCLILQNIKKKIDEIIFIKVTVCDQIIGFLNMNKNFVNLKKLVFIETSLKTSVSLSEHLNVINEIIFNENYLKQKQDEVSDSNDLLCHNITEHIIENLNSGCPKASLEEFIRNREISEENKDLIFKLYNDNVFKNKVKVFEAVDSICKNYIVLCFYEYGGDYKFISITLRRNLNLKQFTIKDTILEKNIYEIHIRDCTITSNFINDILSITSLKKLIIQECEFHIEEPINIRNASIEYFRFWCFDKSDFCRFYEILNMMTNLKKVRVELSEKFVLQFFLAPKLSFQKLVIYNIDSIIDFAAEYNGEILSRFIKSSNIVLVGENERYSLQCLVQVFDLSLLDILTLENYSIYKSDKCALEKLSNLKQLSLTKINFDDISFQELFSTSIEYNIKKLYFEGINIYEADLKFIANLKKLKSLIFEQCTIVEWTSSKRIEMLFLDKSTIKFTFYIENLSTEKIMKCIRQVFAPKKILIFLIEEPYDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3F5</accession>
    <name>A0A4Q9M3F5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0130p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000130">
        <property type="protein sequence ID" value="TBU20111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3F5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0130p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020719596" evidence="1">
        <location>
            <begin position="20"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="664" mass="78940" checksum="335D529031E2BE94" modified="2019-07-31" version="1">MKIRISILILLLNFAFLSQYKIQKRKNYDEGDNDFLVENRNTTEPLHNQRIYFSKNISRIEHNDFHIVSYPRNITSRGGSIEEIGQEGQKDKLFCYSHNSDPFCRHRKHMRDNEPFEYEQRIKKSQRSRDFPYKKSSVGDKNTDSVFENKCFCESRRESLNFDTEERHNKRHDKNFDSNREKCYHYCRYESDSNAVSTGAYLQSDNSLSDSKAACFEKTQLEPSNSFRSAKKNRSSYNSINRCPNNKSFNPDVNSFDEMIYTCGRIYDIFQCLDREYIEFSVIEDFIQGDFSINGYFLYTDYRPFYNLIDQIFAIEERFWSKFYAKKRIEYLAHEMNILLMNYNLCKSNSPLLSYFPGIVNIKYFIRNIILDDMDFVRNSCLWILLIKAAESLCNVQPDSILFNIRKKDTVIFNKYKNFNVYNGDNDAFRVLKTLFVIFYGIAKKIYRCAKISRKYFSMLEFVFNNAMYKSIDLHITFGCHVNFSRVIADSIFRMNPEMIISLISELKRQGISNITDSKSGNRINRLFKRLYVNSSVLKFNNQLDIECIYVNIIESYIDFFKTELLYLNNFRDEDSSYVRKDLLCIEDIVHQYKINNLLIRKLDLKILMEISEALCVIFNHFIKVGLNNMLYPDKYIAKSFFYCNKNIKKILIIFGRLTCLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3L1</accession>
    <name>A0A4Q9M3L1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0131p0010</name>
        <name evidence="1" type="ORF">CWI38_0168p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000168">
        <property type="protein sequence ID" value="TBU19935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000131">
        <property type="protein sequence ID" value="TBU20106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3L1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0131p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0168p0010"/>
    <dbReference type="OrthoDB" id="5987059at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18329" checksum="B889A6DA189BFEA7" modified="2019-07-31" version="1" fragment="single">MKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3S0</accession>
    <name>A0A4Q9M3S0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0039p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000039">
        <property type="protein sequence ID" value="TBU20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3S0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3S0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0039p0040"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="30118" checksum="FECA4A6C391BF7AE" modified="2019-07-31" version="1">MTKISKKDRKNYIFNRTYDLFTTYNKFIVVDMSNVTSNQLQKTKMLWPSGTQFLIGKNTTMKKSLSEHLKENKDLEKVIELIKGNVAFVFTNADFKEIKNVIMDNKRFTYAKVGSISQCDVWIEASLTGMGPDKTSYFQALGIPTKITKGKVEIISKCKALTTGDKVGPSQANLLYILDVKPFTYFMQLKCVYENNEIYDSSLLDITTSDIFNYISQGVSSICALSLGLGIVTKASLPYEIINGYKNLLGISMALEFDIPETIPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M465</accession>
    <name>A0A4Q9M465_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0088p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M465"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0010"/>
    <dbReference type="OrthoDB" id="2196121at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="23075" checksum="D52BE532E36AF7D8" modified="2019-07-31" version="1">MIDCIYTKHIKQKSKKWLDGFFTHSNSILTLYNTEKKKIYSFRIKYIDNEIKTSMYLIYIDNIKQEDLKVEYNKEEDLKEENRVDDKKNIRVEYNRVDDKIENKIENKIDNKLENKEEDFKVKKYEFNNIINVKNNKPNLKNNKIIKEDNKINIKDTKIYKEDNKIEEQNAENKRKPRSNKEIINLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5V9</accession>
    <name>A0A4Q9M5V9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0009p0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5V9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0160"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="566" mass="66578" checksum="F5BE89D4C7F8877D" modified="2019-07-31" version="1">MKVKKTGISSIECFMMEMIRIIKVYIYLIRTVLRANLICVYLLSFNKIYCADNLKVEETTKENESEHIYLNFIYECSDAEISEFLKTKNPRCFCENKDICTGTHVDSEEKFCSNSIPRSSHIPIYVKKFETRGKYNVQFEAIENMFEKLNETPSNSKSISGLQNIYIEHQISIWQFNILENFMLKDYDLTMLDVLDSDIEGMWIFIDFLGIKPSLDTDWFFVKFFKKYVLLTEVYKKYLLEMQPDWFGFFTGVYLDSEDRDGILLGSKIVELPSCPKTEEDIEVLDPNDTRSEEVRRYGDEGFVLEDFTDQCYSRNMSQGIYFKNNIGFKIVTDAIQKLHNFCSFKKYKQILAIFLGSRIYKSLEVTNINFEPPKKYRSPNYDTERINNTFNFDGMEPSSTHNTLKRVFISDSFKKIKELNLNMVSLGELDANRLYDLRCLVRLKIKNPNCKEIQRSVSRLIRCNINLKVVNLFQIIISRWFIESISKILLETIIFKKCNLETDRYIPVISLSILPKDAKFVSTLKKFVLEGYCKYSFEIIEHLDLYTNLEFLSLNSCFRSALQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUZ2</accession>
    <name>A0A4V2JUZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0572p0010</name>
        <name evidence="2" type="ORF">CWI38_0014p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000572">
        <property type="protein sequence ID" value="TBU02032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0572p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="307" mass="37066" checksum="294557FA8A0A578F" modified="2019-07-31" version="1">MEIKKEFLPTFKKHLSTEYLKNSIFKEELSKIGIYKLLNYKNSTIYSFTKNTLKVSLVPLKISEIILKSTYEINTAIFHNLNYQFYKFLSLQNIEFVKLVYKNNLFQNIYKFVNKFPGKDKIEIIHNKNFLKYNSNLIQKPKNRQIVELKSKENKFLTFFKNKINFIKGFYNKIEIKENEIKKLENEVLPEILFNINKLNEIKYFFVESGFYQTNEFYNNLIQSYFDSIYNISLVRYNNVESDGIVKVNGIESIKFIFEVKYSLYGQNNSFFKTKKNKNFLIQTEFIKSEEHNNLWKVKEFFYEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX31</accession>
    <name>A0A4V2JX31_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1931p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001931">
        <property type="protein sequence ID" value="TBU10222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX31"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1931p0020"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="744"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="973" mass="116733" checksum="39C5713EE73F1FA2" modified="2019-07-31" version="1">MKNEVFEKYRSMVLNMVKYTGKRKPTILSVKKRGNYGINILNEILRKKFNEDDYNLYISLGLEIVKCLYIYEDKLRIPLYSLYKVLISLYEKCTDENTKFSIFKEILEKSKSLEFNETKEYFEIKISIEIIKLKNKFCETNLNFILSNILFTSEIFQKKVYKILEKEKSKNNKKLKNLNEHEENNEIKFIDKEMLTNSSGFKLNISRKLFEIKNFKNLNFNKNEIFAEEVKFSEVSVEEKIFLRKYFYFLKELKLESNFFKNIFEDEEYVFIEHIISTDIWSLSFFDEDYFWNPFFGNQNNLNESKSLFLYKEKYNECRNEYSEIIRKAFLQLKAKKCNLIELKILLHYLKKIIKNTTKNTNFNLINIEILFLNSLIFILEENYLESKNLLRKVLLILRKNNFKNIFIEIYLHVYNLIALSHFYLAEYFESVYYLDKSLDLIEEYGLNKYKFNFINRKLFVERFANIYGVSPNISLDLFKRDIQFKNDKTFFNENEKNLNNRILFNSVLNEIIDEIRELRLFEFSEEDSFKNLRKENFENSKSNKLGNNCGAAGNLDLERRIYGNSKFSNEKLGNSFFKSFCNSNDFYRKFEIFYKRFSHVGLFSFYSLNDILCINFYFFDKNIFECKTQKTKIDLKSLKNKLNKVLSTSRETLKMKVESATDKKTWWDIRYKLDKELRDIIFAVNSELKEYLNTKNINIIILDESTTFFPFESMKIFENVSVYRIPSVEFLFQRLFFESKKILQNIFYVLDPENNLPDTRSTIKPFLETLNFTEGIEGKPIDFEIIREILQKDLFLYFGHGNGERYFKPYLKEKQYISKSKEIYRYSEKTEENHEYFESEITNRNLNKVKVLSSNYGTIKSPVRSENDKIMLLFGCSSAKVLCVDNFKRNGIIYKYLKKFSTILGCLWDVTDKDIDRFSLEFLDNIFKNETLDLAAFMQKSKKNMKLKYLNGASLVIYGMPVILDFKEYISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX43</accession>
    <name>A0A4V2JX43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1796p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001796">
        <property type="protein sequence ID" value="TBU10392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX43"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1796p0010"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="2">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="26750" checksum="CA92FEE5871507D1" modified="2019-07-31" version="1">MVKNYHYYNMFSPDGTLLQVEYALEAANNSIPISVVQGKNIVVCAYKKQTIELLEEHVPGKVFQVSKNVFVVITGILADIDQIIYKIKDMACSLEYKIGMPVSSDILCRSFADKMQKLIQSTGERALSFNAVFISFDNEDPVMYYTDTSAVVYPYFAVGIGEHYSRINKHLEKKYTKNMTEQETIDLAIESLSESIGAEFNPNDIAVVYFSKDLILRNLSVEQIDTALMRISEMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX94</accession>
    <name>A0A4V2JX94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit d of V-type proton ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1479p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001479">
        <property type="protein sequence ID" value="TBU10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX94"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1479p0010"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="40657" checksum="334A92919A9F7480" modified="2019-07-31" version="1">MDSSYTNFEKYGSLIAEIHGKVSSMLQQSDYESLEQCETVEDMVVRLSHTSYASYLSEELQFNKKEFLKRLNKSFYNEFMYMYRNSENDLKLLLNYFIEVIKIQNFIFLLASKSEDPDLKCMEEIDMLGNFNELDAIKISADMSDVYKFCVESTFLKKYYDKVYIEKEFAKNDWQIIQSTFFKNHIENFYDQINNLDTMDYMKEILKYEGDRKIIELTINTLDSVDIVDKKRIDLYPTVCSFDRGSICKMSECTSMESIRDVLCGHPMYKKIVMYEDNDFMKNLFDLEIKNYLSSLSEFNDLSCAYCYFKLKEREIKNIMWIAECISHENKEGMKDVIVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX97</accession>
    <name>A0A4V2JX97_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1468p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001468">
        <property type="protein sequence ID" value="TBU10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4V2JX97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1468p0020"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1289" mass="148448" checksum="A6EEBE0FE9750CC1" modified="2019-07-31" version="1" fragment="single">MYSLLSPDDLEEEIPFSIKILCSSVEKTKFIKEVLIPPIRKYQAILYTLKTNTPYSLPFLQKVSKKEAPDYLKIISKPMDLGLISRKINNYSVEGFYNDLELVWRNCFKYNCNNIFSEYCCRMKELCYKVLEYNGIGVGIEGVIDSRRVVEGVIDSRGVVEGVIDSRGVVEGVIDSRGVVEGVIDSRGVVEGVIDSRGVVEGVIDSRGVVEGVIDRFNKLEGVSNSNHNYHPVNDSTSNYHPVNDSTNEQTPFNDSTDIYHHVRPKEYWCYGRTGEMMGYYYSRECNNTLLYESIDNYKDMLEGVNDKDMLEGVNDSTSINTPLNTSIGNNTPLLTHHTNNTPLIPMWDGEFLCNSFPVNYIKSDVSKVGVLFLNKYKNMIGLEEIKWGFQKEFKGGVYFKGKRNLKVSFLDKECVKSVIGDLFVIEVGKVGFKRVSKMAVDIAVDVIVIKRVLIIRSVINRVLIIRSVIKRVLTMRVVDKRVLTMRVVDKSMVIVRFICLECIIWVFISGCVCSGYGYLGVLEEDCVIFYDMKGFINNGEEGCVLSKGGICKERFTNNNEEWCVGMKSGVCKERYMNNTEEGCVGIEESDLVINSVFMYKLREFVVFEYFDRCLFPIRLESYCRGFVSVNHDILYFLKMCSAFDSVTVGMSRFDDKYLSKYFKLCISGYECEKYEMYELVLNLLIFLSVFDARNTKNVRIIVFYLINQLFACKIDFSGFLNQNIDKVLLGKNVSKLFIEDLMICIFNTFTLNVRKCGKCFILSACKNKHVKSKLLSTEDFSFVILDFETLLILEKLLSDVMFFDFLDKILKYLNINLLILCGIHIPLGYFRKIYGSIFFINSFTSITLISISGKFAVLFEMLRHKISKDLKNISFINMNLREMEYNWLLEHNSLESIKIKFEGLQYCHVCLHELYNSNQTLKDICFQSVRITKNYWKSILDLKNLQSIVFKKFTVIELAKEFYIGMKYCKCTDSLTRFEIHDITGENLVFAFDFVFLLKKIRILKFIVINGYVNLFLPRTYNMKMNDSLEEIKFFGLFINTFCVRYILRNAGLKSLVLDDCRFEGCSFKDLGSTSLVTRLQVLKLKYVSISVEDLKFILELKNLVDLEITECRFCLLKSSKLNSERCFLREKPHSTKDTENNFSLAIDSFAKLEKLKIYNSGIDLMKSNFSGYSTICSKIKKLTISNTDLYLKDMQIISNMRSLVSINISGCVLNNCCISNMKNPSFLKNLLSLNVTYIPLKKPDISFIISLKKIAKLKLSIIYLDISNIWLFNSNNFPSLTLLVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXB1</accession>
    <name>A0A4V2JXB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1344p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001344">
        <property type="protein sequence ID" value="TBU11172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXB1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1344p0030"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="76"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="35219" checksum="EBD92E062832AA57" modified="2019-07-31" version="1" fragment="single">SSGGLSNSSKDSLINNTSGSNSNTNTSYTSSSNSYVSNTSYSSNSTNPSTSTNTSYTNPSTNTYTKTPYFIPFCSDGVICELEEVIEVLFTCMVNYYRRVLMDYIPYSIIEYQGLKEFKCKEGFFNGWGGGGVSINKLVGVLDWMYGMLIFYCLPLNFCMEGVNYILKVINSVSFNALLVHKGVLCLNRGIQINNNLNFIEKFCRDIEYSEGVLNMGHIKSVVKLVNYVNAGAKLETIMDECSFLNVLQVKILFSKFKKEECCYEVKVADFSMEKFIREPKVYVPGVKDYSYHTFSVPRFLPSKYISSILGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH4</accession>
    <name>A0A4V2JXH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1063p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001063">
        <property type="protein sequence ID" value="TBU11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1063p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="38710" checksum="96CA0696DF2C0CD3" modified="2019-07-31" version="1" fragment="single">FILQNINHLKEKINEKFFIKNIHLFPKLLEIRTYIDFLKIVFFSEYFRKPHVFLYFGIKKIYFFSIKSYKRFQILNNKYEEIENNTEKVFFGIFLDLIEIFYKLIDPNTKLNTSEKIQIRLERMKYHIRIKLATFLYKSYILVSNKTLRIFKQQISPKIFNFKYFLKTLNYRISQKIDINRIYYEDLVFKTLITIKNIISQQIATKRIFLENLYKEIQKLIFYEIPETTKKFFFYLKNILKNLHQTYKELKNISLKLKLKIKNSEYKIEINPLNTHFLNQIRNEILKIFQKINIFSIEFSYEKENIKENEIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP0</accession>
    <name>A0A4V2JXP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0730p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000730">
        <property type="protein sequence ID" value="TBU12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0730p0010"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20280" checksum="1B8484EC84D097CC" modified="2019-07-31" version="1">MNLIIIGPPGSGKGTQSKLLSINLNLYHISSGDILRDEIKKEFGRQISVKIQKGEFISDTFMAEMVMCRIGEVEGGKGIILDGFPRNLYQIPFVTIEISGVIFLNVSKDICKKRVFQRNENRSDDSDIVFENRWELYERSTLEVVEYYRNKGKVVEVDGSRSKEEIRDFLVKYFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY32</accession>
    <name>A0A4V2JY32_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0238p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000238">
        <property type="protein sequence ID" value="TBU18512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0238p0020"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="97169" checksum="F8D42B18F2D0710C" modified="2019-07-31" version="1">MYFFLRSRHFCSTFPVRNIEIQSSRSKMFMVMFRCLIVDLYGFCFLNAVHSATLSNNGRIKFALIDWNWIEAITREDLAAAKYWLARQNENSVLDFCPGNHFFRNNRIYPEFFVCPHGLSFLYHKPLHILEVNYRDDWKVRFRVLNYFLSKNSNEPFLFYRSSFGISYPLFSSFVKYLTCDSFDSPNDLSYELFYKFIKILDVLDPISSDFLSEFYYKLYKDGLMNSISVDIINDSENYRLRFFNEKKRRRPFMYFFGVLNDFLDACLIPNISMLSIFKKKNQSIDQCFRYTGEVDRLVLKISACSLDFLMPSLAENAHIFNWLLSVTEISGFYFDNTEFTFNPINFKNVCGFMPPEIPKKSSDPLQTVPSDFIIILNDDNQRRMQYLRFVNVDICFDIFEKLLYKTNISYFEVSYCSVDECHKITELLEQMPELNVFILHGVGIRPDDLDRILFSKIEILVLVGCIFESDSVWISKESPDFVYEIMKNLRTLNVSASKLPMDFMHILLHSFNLENLNISRFEFLPANSSFSPIGLRKNRYSLQLDKYIPNKYLEMFSRTYFANFLSLCDSFIFSDIVFFFNIGDLIDSVKFLDLSDNLFSVEFLTLIDNFKNLKKIKLSASLPSSTVGLPNLGIFETVMALDVSRNDINATNYDFVSKFKGLKSLSLANCKLENKLLKKIMTKDMCANLISLDLSGVDLCFLDFKKIFCCKKLKILYFQISNDHPLSYYCDYLELTSAKLNLNVLKMEIKGGVCFDDLVSLAGFSNLSKVKITCSTFIKTGEENFIRFNPKISNFRLELCLKYYNLDIDTLDILDEMFENCSISIVSPHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY83</accession>
    <name>A0A4V2JY83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0128p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13011" checksum="F32EC8F4CB910F29" modified="2019-07-31" version="1">MNVKAYIQSIVLKKTVETISFDRRRGLESGLNAEESRERASMGVIMKSEMHEEPTPFLKEEKREEDGAKNFKPKNKAPFISQGGTTLEESINNINKEPDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF6</accession>
    <name>A0A4V2JYF6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0013p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000013">
        <property type="protein sequence ID" value="TBU20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0013p0040"/>
    <dbReference type="OrthoDB" id="155387at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="41361" checksum="D96673485071F7F3" modified="2019-07-31" version="1">MENFEGNLLNLESRDSKYKQLTKEQRQSILEKLLQQMKKNKLKHGPINEFATLLKYVPIFLQKRKKDAEENLRLFEQFSANKEYPINRRGTLRSLSFAIGIPKSTLFDIFKLEFCLSKVNLANNGDFFFDDLYDYVHIDEKWFYLTKVKRSYYLMLNEEKPERNYKSKRFITKIIFMAAVARPRYDAHRKLYFDGKIGIWPFVYQEPAQKNSKNRAKGTMITKNVESVTAVHCKNMIIDNVIPAIKSKFPPAYKKKTIYVQQNNAKPYFSDNDADIVALASPHTIDELINCVQDAFHQLEANTLDNVFTTLQTCMESIMFADKGNGYKITHLSKGKLRREGRLLEKYVFSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUT1</accession>
    <name>A0A4Q9KUT1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_1796p0020</name>
        <name evidence="12" type="ORF">CWI38_1817p0020</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PITJ01001796">
        <property type="protein sequence ID" value="TBT98345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001817">
        <property type="protein sequence ID" value="TBU10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUT1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KUT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1796p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1817p0020"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBT98345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="277" mass="31664" checksum="FD60D66BE78DDFEF" modified="2019-07-31" version="1">MSNIIYKKKLGQHILKNPGIIDSIIQKSRIKPTDTVLEIGGGTGNLTVKLLEASKKVLCYEKDPRMANELIKRISSNKEYNNKFQLFVGDAIKADFPYFDMCVSNTPYKISSPLIFKLLKYNFNRAVMMFQKEFAERLCAKVGTSSYCRLSVSVQILAKVDIIMKVNKNNFNPPPKVESAVVKIELRHPRPPIDLEEFNKLLRVCFLRKNKTLSGIFKNKSNLNGFLIENCDSNEIQETVISVLEKSGFSDKRASKMDIDDFLLLLLELKKQNINFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZA3</accession>
    <name>A0A4Q9KZA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar import and degradation protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1029p0020</name>
        <name evidence="4" type="ORF">CWI38_0946p0020</name>
        <name evidence="3" type="ORF">CWI38_1244p0020</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001029">
        <property type="protein sequence ID" value="TBU00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001244">
        <property type="protein sequence ID" value="TBU11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000946">
        <property type="protein sequence ID" value="TBU11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZA3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KZA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1029p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0946p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1244p0020"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="1">
        <location>
            <begin position="262"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="592" mass="68074" checksum="AA35F503EB92F91C" modified="2019-07-31" version="1">MVFAFLKSFLSRKKETSLTGNLYKQKTLILQNTSIYHKDTDILFKTSEKETPIKIPIKKLSKLQINTDPNISLDFIFNKEKYTFYILTSHPIQSLTLFYNNVYPLISNTPPIFHCSSVSYSTYDSLSSQFIVMDGNTSVTLIQENVQSFLRVENQNEILHFEQISSDTQFYMDKKLRTFVWSILKENNFYTFSLQFSENLSFLEFVSKYTNLNFKSEESEHIPEKYYQDVEFNYESESSFEDVDYQSDVFNYEESKNDEKEKNSVLALDNDRVFVGRGGSIGVFRKGNEGLEFKTNMKNVIGRESTDNRADVSKMLIYGDGSALICMDSTDQNKLMKVDLNRGSIVENWDCKRKINDFFDSKKQNNDDTLIGVSDNSLFRVDPRTKELVIEGKSYKTKCGFECGVTTSKGDVVVGSEKGDVRLYDKIEKRAKSLLPGLGDKIVGVDVTRNGKFIICTCKSYLLLICLESGDYSKSIKEKPIPKRLGLKPEHLAYIQEEVNFTPAKFSTDNREESIVTSTGHYVIIWNLKDILKGRLFSYQIKKYGDTVVTDTFDIDNDENVIVALRNDVKIAKKENMKNFERVVRGGGMKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L630</accession>
    <name>A0A4Q9L630_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0428p0020</name>
        <name evidence="3" type="ORF">CWI38_0028p0110</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000428">
        <property type="protein sequence ID" value="TBU02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L630"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0428p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0110"/>
    <dbReference type="OrthoDB" id="2196350at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="510" mass="46746" checksum="AE418F15B6D7A12A" modified="2019-07-31" version="1">MKNPDIVNIKDVLVYEKSPGVFADYTGNVEFKKVGEEIVNENGIFVGKDCGCGKEEIPSKGQLTSNGVYQSNDVSQEEIKKESDSLDKLQKEIGGGSQAGGPTSQATGGGTSGGASGAPTSQAAGSGTSGQQSTGGTSSSGGGGTGTGGSGSGGGTGGGAPSSQAAGGSGSSGGTGGGAGGGAPGSQSAGGGGSSGGGTGGGGSGGGAGGGPSSQSAGGGGSGGGGTGGGGSGGGAGGGVPSSQSAGGGGSGGGGTGGGGSGGGAGGGGPSSQSAGGGGSGGGGTGGGGSGGGAGGGGPSSQSAGGGGGGAGGGGGASSSQPTGGGGSGGGSSSPSVGGATSQKQPEKESATPVSLAPTVQMPTGCGIMLFTNSTNDCLQKGSADTSEQVQSNQDQFEIGSVEFKYGEEPRTECNTLTVTKSLKDLLATIDKNEENESLATLNSFSSLITTFLSSSSSIQIPNLSTTICDVSSDETVTINTTIMVEDNDCLQKCECTQDQCQNPCYTNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L634</accession>
    <name>A0A4Q9L634_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0442p0010</name>
        <name evidence="3" type="ORF">CWI38_0496p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000442">
        <property type="protein sequence ID" value="TBU02625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000496">
        <property type="protein sequence ID" value="TBU13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L634"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L634"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0442p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0496p0010"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="176" mass="20977" checksum="E7E3B5EA0AE98014" modified="2019-07-31" version="1">MGSLKRVKNNKKILNTLQTTYEFRKPYQIIFEEEFLKKINKSKLTVNYFYKLFFSSPKFFITECSYKIYKSKNLNFENDFSKYCEIRKCGHTNLNTEECLSDILKKNNKFHYFVATTNQKLKNTLSNLFFVPFIHLENNTLILESLRKNTNFKDNTLVITEISSDKNITNENVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8D5</accession>
    <name>A0A4Q9L8D5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI37_0289p0020</name>
        <name evidence="16" type="ORF">CWI38_0097p0050</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FI-OER-3-3</strain>
            <strain evidence="16">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PITJ01000289">
        <property type="protein sequence ID" value="TBU03475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8D5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0289p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0050"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="61"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU03475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU20282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="432" mass="50037" checksum="B07275E66BB71988" modified="2019-07-31" version="1">MKLITDAVWSLSSIHLKLLILIEKLTKEKISISPSNIKKYLKIPINYTEYLTDLVRNKFLRYKNDIYEITISGYDCIAINSLRKTGLEFMGDKIGIGKESDIYIAKYKGENVVCKFHRLGRTSFRNVKNKRDYKITEAGWHGMSKASSLQEFTYLKMFYPYFCTSPEINSASNLESSTQNLYLGNTSISDPLVSETSKTSNTSKLYPEIYIPKPIELNRHVIVMEYLQDYYPLYKIHSTDPHKVFSSMINFIYQFKDMGYIHGDLNEFNILVNEQNKICIIDFPQCINLKNKKSDEYFNRDIECTRNFFIKKYNLKFVEEKENTGLEKSNTGLEGNNTEVEGNNTEVEKSNTGLEGNNIGLEGNNIGSEGNNTEVEENIEVEEYIEQEENFTSLEVIQSDDEKESAQAKDIIEDKENITKNYKESVEWKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC81</accession>
    <name>A0A4Q9LC81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0101p0030</name>
        <name evidence="4" type="ORF">CWI38_1151p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000101">
        <property type="protein sequence ID" value="TBU04681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001151">
        <property type="protein sequence ID" value="TBU11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0101p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1151p0010"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="165" mass="19788" checksum="EE085C9D09023AB4" modified="2019-07-31" version="1">MYKKIENFDYNIEQHINSKLPPSETLNNFNTTFFLNSDFIKNEKQNEKRGIVNLNYDGLTYDQFTEINVLHTEYIKEMKVNLSPTLFLPVLYKAELTGAFLKFKKENKRCEGIVIEERENVFVMIDILNKIKKYPKSINNFVFTHDNVDYYLFGNRLKKNRFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCJ4</accession>
    <name>A0A4Q9LCJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0088p0040</name>
        <name evidence="2" type="ORF">CWI38_1740p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000088">
        <property type="protein sequence ID" value="TBU04791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001740">
        <property type="protein sequence ID" value="TBU10468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0088p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1740p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="264" mass="30708" checksum="930A06534AB7E799" modified="2019-07-31" version="1">MSFWNTKAFRISAIVVAALLTIFLIIGSIGYSKAGKFIKEFEEDFKRISETDQFKTRVTKLKQTNSVLLMMHEVFKFIWILDINKNDKTREKFIEAIKTKDSFKIFECLAELDRNKVVEAMDLSCLLAFDPEKVSKLKPKFGFFATIGFLFRKRHPMKDIYKISEKIGIKLKDCENSALILILFLDILDDKKIEISEFDYDKIKHNFDFSSDTFILNSLKRNDKTYISADFIIYLAEKAATSSEAIIEELKQNLILAIKENMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCS1</accession>
    <name>A0A4Q9LCS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2718p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002718">
        <property type="protein sequence ID" value="TBU05723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2718p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="283" mass="33018" checksum="1D475226ABCED346" modified="2019-07-31" version="1" fragment="single">CSFKRESDYSGSFKLQNQDKNAVEICSFKRESDGLKEEKFYFIRELQLFQFYKKNIIELENHKNKTETIVAPKTILCLPYTKNIFLEEQQTVFLTTKSLIQTELNDNYSSSAFQENIPSKSIRQCNSSNSFEEIESFKNASNFDSIETHISIEPHIPIETHISIEPHIPIETHISIEPHIPIELHIPIRNEPFLNQKPEKTFKSEKSITEDNLNPISESKKINSNLHPNSDKTKIKELNIQPTKKPKLIISHNDGYFEHSSDIILSQLELYDEEELFLFDQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDP0</accession>
    <name>A0A4Q9LDP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small subunit of replication factor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0043p0060</name>
        <name evidence="7" type="ORF">CWI38_2400p0010</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000043">
        <property type="protein sequence ID" value="TBU05161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002400">
        <property type="protein sequence ID" value="TBU07433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDP0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0043p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2400p0010"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU07433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="313" mass="35633" checksum="8C723CB92EF790CB" modified="2019-07-31" version="1">MVLPLTEKYRPLILTDILGNEEVMYSLQLLVQNKILPHTLFYGPPGTGKTTTIRAISHQLYPSHTKSHVLELNASDERGIDVVREDIKNFASTVSLHGGQKLIILDEVDSMSKDGQNALRRIIEDFSENTRFCLIANYQSKIIPALQSRCTKFRFSPVCSDKVHDRISFICHQENIKITPDGLSALLSIFDGDMRKLINDLDGIISCYKIINKTHVHTVTGSIDKKEYINIYNSLISDTFDISYSTITHFKILHSIDLQSIIQEIVEVLINENIKNKFKILKNISDIEYRLGQGCSEDIQLRAFISCFKLNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE31</accession>
    <name>A0A4Q9LE31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras GTPase-activating-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2699p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002699">
        <property type="protein sequence ID" value="TBU05826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE31"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LE31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2699p0010"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RasGAP protein C-terminal" evidence="2">
        <location>
            <begin position="186"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="47746" checksum="318849D18A055A32" modified="2019-07-31" version="1" fragment="single">YIDPFYSLICDTPLLKVNNNYPIKFYLNDPSLKKVEEKENLNNLISIIKYKMSVLLYFSFGKNVLDVVLRESKEEENKEYLEKYKYLERSYFNESVSVDSVSRDSRDNVFDSNKFDNVFDSSNIRDNPYNTNTNTPYTNTNTNTNTNTPSNTNTNTPSDTADYCTCEQQGVIDSTFNLSKKLPENLEELKSEILDSLNFLESVGILKKSNLYVDMLFMISNDVLVLRSMNEERNSEMLVNKMTLNNLNMKNEYLKEKVRVHEEYLISFAEKMVGIKKKSFFKFEDSRISKLNKQSVYGTYVFSANKMKRKNVLLEIYNYNVNQYNGIFFLILCDKPNFFCVEMYVMDVLVGDGVSVRLDELLRSRFKGVSDMDYCGVCRFSVKGVLELINECYINFSMVLELINECYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE38</accession>
    <name>A0A4Q9LE38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2616p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002616">
        <property type="protein sequence ID" value="TBU06217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2616p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="54" mass="6436" checksum="F4FE94B1EADD16EC" modified="2019-07-31" version="1">MSKNTADIHVYRSILQSIVFKKKIEYISLDRRRELKLKQNAKDCCQTPLKRVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEG2</accession>
    <name>A0A4Q9LEG2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2666p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002666">
        <property type="protein sequence ID" value="TBU05986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2666p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23018" checksum="FE3D256D968D32EE" modified="2019-07-31" version="1" fragment="single">VKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMSVIMRSEVHEEPIPPLKEVKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNINEASDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEU1</accession>
    <name>A0A4Q9LEU1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2562p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002562">
        <property type="protein sequence ID" value="TBU06513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2562p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="31142" checksum="6AD7BE79D643D93E" modified="2019-07-31" version="1" fragment="single">NEAVFCYIQDRNVFRGADGVCQHCGKSGKTVDYLAARCEKMLDHDYTRQHNEVVRCLHLLLLNRYKFKSSKRIRKIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANDLGLIYKCSVEIIPYEMTRDGIVTKYHKSHLKRLERNTHEFRGIYLLYSTQEDIETISFDRRRGLELGLNSEESWERASMGVIMRSEMHEEPIPPLKESKTEEDGAKNFKPKYKAPCISQGGTTLEEPTNNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFH7</accession>
    <name>A0A4Q9LFH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2507p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002507">
        <property type="protein sequence ID" value="TBU06789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFH7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2507p0010"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU06789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="247" mass="27814" checksum="2FAE85D37CE25727" modified="2019-07-31" version="1" fragment="single">TNSITNTVEGVIYKSYFFHKGPVFSIKEKEGIIITGCYDGRVGMIDIKGDYYKYFKVHTNSVFDLDFLDNERVVSCSSDYNISVINTRKGCWNIIKGHEGEVNSICCKGGVILSSSDDKSVRLWDVDRDKSCIFKGHLKAVYNSKWVEEDIGSCSGDGSVRIWDVEKGCCKDIYSHNKGVLNIEWCDDKRVLASGCVEGRVIFWDLRVGKVGEFKMGKSVQDMSFNGDLLCLCCSESEPVILNLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG43</accession>
    <name>A0A4Q9LG43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2639p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002639">
        <property type="protein sequence ID" value="TBU06121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2639p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="16420" checksum="48F53FC7F7036530" modified="2019-07-31" version="1" fragment="single">NELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPTSLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVTVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJP3</accession>
    <name>A0A4Q9LJP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2287p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002287">
        <property type="protein sequence ID" value="TBU08247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2287p0010"/>
    <dbReference type="OrthoDB" id="106984at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21407" checksum="516F1C32CC3D5DBC" modified="2019-07-31" version="1" fragment="single">DVSTSTIDRALREFHYTLKRVTLVLERRNTLSTIELRTNYATSFRELEVDNDDKNFVFSDEVGFAVETRCSRGCNMRSESAYLSVTAARTRNISVVAAMNKYGMIYHKIHERAINDEDLKLYIKEINESFWKNKVIRGGARTEPQLRILICEKFNEITGEHCSSFYRKMLGYLQKSEEGQVIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKF5</accession>
    <name>A0A4Q9LKF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2255p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002255">
        <property type="protein sequence ID" value="TBU08497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2255p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="44903" checksum="5D74FD94B15751A6" modified="2019-07-31" version="1">MKEQIQSPPLQTQQPPTPTDYKPTEIKPTRSRAGLIFKLVGIFVALLAIAFCAAKYYFAFVDIDEYCYADYFYTWRVKYADSALFEKVYRFVQKNSYYEKEDEGKVHKFVQYAQEGDRMLFDGYPEHSPRGDFKRYYTLNFKGNEKYLKFRKSMVNADGNAITDSELLEGKKEVGKKDIHYFDDKVTKEKDVDIKKILTKDEHKEIFTFLKDNLFPFLQKCRKGDFKEKIGKKIPDEIVQEVKKLAEAGVKLGGDDVSITDDHVKKFIGGMGVIKLDAMECFIYSRIVYITLLSVADILGDLKVDSKLTSKQKDALPKYKHLLNGSRSIARMLTGMYEHPLGSSQDTKDVNGFRKFCRRRLGLKPATLVSEDEENMDLILKKLEERIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKJ2</accession>
    <name>A0A4Q9LKJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2265p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002265">
        <property type="protein sequence ID" value="TBU08416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2265p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="18875" checksum="7BA57B09567B0A68" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDANEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMG8</accession>
    <name>A0A4Q9LMG8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2100p0020</name>
        <name evidence="6" type="ORF">CWI38_2182p0010</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="PITK01002182">
        <property type="protein sequence ID" value="TBU09116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002100">
        <property type="protein sequence ID" value="TBU09872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2100p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2182p0010"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU09116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="29464" checksum="B9C9743A373655C7" modified="2019-07-31" version="1">MGQAVFVMGPAGSGKTTFCKKLYEHGIAIHRSFHLINLDPAQIQENTVYSVDLRDFVTVEDIMENYDFGPNGGLIVALEELYDNIDELDLESLSSDFLIVDCPGQIELFTHSDTFKNIVEHFKKYFTCCIVYLIEAQFVSDPTKFISGCFVALLSMCRFSLPHLNIISKLDQLEISREILEEFCQLSESIKDHIQKKKGEYNQLCLKMYDFIVENNLVSFLELNYDDENTFDTILYSIDEAVQYFDDAEPKDHSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNS5</accession>
    <name>A0A4Q9LNS5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2066p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002066">
        <property type="protein sequence ID" value="TBU10049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2066p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1175" mass="141419" checksum="3B43924505CF9BA0" modified="2019-07-31" version="1" fragment="single">MDYTIENTEIFLNSTHYDFVLNETNCISKNDKLENCLIERFHFLFWYSISQTLSFIVQPFPTKNDAELFFSFYEIFLDYKFDINLLENLRLFINKNLSFLENMIPRMCEIINKIFEKYITLHDLQYNQSKDFQDVMNSIFFNLTELRYKVNIHKYITVYLEIIKILDKYHHLLKITNIFHFLNCATVKNYNLEKIGLLSDIFLQTINLCIKLSKNMCLDDENMKIRIIKIIITKIETFCNDKDKLLELFYELQEEHKNIFLFFYNNHSILEKFENDIINYYHKTIFLEIVCNNINSNINYDKRCNYEKNCLLLQGLKTSKYDLRACLKYLITLVRLSKYANTITKEEIYNLVSYNNVISLLEQNIDEIAKSNHIIFNYAFSYIIYLLSDEFYHLSSFLKFLDSNREIPKSVLEYFYLTFIYMNSNLDKFANHEIYFEKNILEINIKIVNDVFMSLEKKNYFKSIISLQILRELLSIHPYYFNFIKDKMNKAFVQKMLCLNSSVVFINLEQQEKWNINFQFGFLITVILYKCESEFLQKYVSILCSLLSDCNDKKILISEICCCEIPEFFSYKLNNKSQNKNCSDSFQKRKFKICQAFIKNNILKILSESIRNPRFIESNTYEETGHYNLKLMSIFVAYLNKNNPLISISCLITYPYICSYRIGCFQFIRTKYIESNDENSFNISCKNLLSTIDFGYMTRFHAYTEKEFCEYKFQYKNSIVENLNIYFDRFTFFDLYLNLFGYKCESFLNEVDNLKKKIIQYNFPNEVSNAIHAIISNNSENMNEKPEFSSYVTKYDYSYIFKTNFIPIKRESSLMTYVNYFLTNKNVTQSFSEDDYYDCYLDAIFIPYEYIHKFCISIELFRTIFIMLSARTTNLEFFRNLKLKLSEIEKMRNDEYFKTKIDFLKQILINMEEYSLDSSYEIFEMFLFELIFFKITKNFILNEHSEEIIKYLFDSHVKTSYKSNKIFIDILSFESYLTTRKIYKAYIENFQSDFYTDRINRILNDENFKQSSFSFFDIILKNCEIYFNLRKVSDIPLSNDFIRKKYKRQKKNINFELNFFVGFLESRIENNLIDLFVNYTGLETKKLILLWNYYKKLVNLQGKFHLAVKRDSVIDSFIENIRLEQPSEVKTQMWFVHFTAEDGTGIGPTFEFFDLYGSILNENEYFIAFANEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP02</accession>
    <name>A0A4Q9LP02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1983p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001983">
        <property type="protein sequence ID" value="TBU10148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1983p0010"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="15954" checksum="1459EBE625FE282A" modified="2019-07-31" version="1" fragment="single">MGSWKKVDSENMKTEKIKAVNNLEKGASEIFMCDVDTSTSTDQPPSSSCQTSPVCLVDTIPSSSGTDATAFGPAKGMTNLNTDALLKGNRLMVLHSILDSVTVVEQEGPRSAILAVQKRFERMPRNGWPATLRYYNEKFSCTLDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB7</accession>
    <name>A0A4Q9LRB7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1967p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001967">
        <property type="protein sequence ID" value="TBU10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1967p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15787" checksum="EE395FE023D0C4CD" modified="2019-07-31" version="1">MNDSNHKNYESDETNSYLQIQDELSKYYDKISINQPQKHEIQRYSDKYYKEPLSNHQKVIQSVPLEILPPELQKYYGYSISTQKPSTSFIIESDSSTSSKESSNTNSCIDNDYEEVELVDREDLNIESDENYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM0</accession>
    <name>A0A4Q9LRM0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1973p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001973">
        <property type="protein sequence ID" value="TBU10165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1973p0010"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="23085" checksum="943D3A1AB2642068" modified="2019-07-31" version="1">MKLYNINECLENNQENIQNRRKMYWKTKEALRRADRTKIDLKNIEMIELLLNIEKNVYFKEERQLETYPEFMQRCKSNFLKDFICCNNIFTDFDTYVMHVQKYHQTEIEAENQSSINNYENFQLLNYDFSNFQIPELNLLNEKPYFGIKKPYPCKVKGCYKSYKNPNGLKYHMIHHHSDIVKDQKENYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN1</accession>
    <name>A0A4Q9LRN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1957p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001957">
        <property type="protein sequence ID" value="TBU10185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1957p0010"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15050" checksum="6F75CAB120E3571C" modified="2019-07-31" version="1" fragment="single">GIVTKYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP2</accession>
    <name>A0A4Q9LRP2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1579p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001579">
        <property type="protein sequence ID" value="TBU10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1579p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="370" mass="43132" checksum="BA64CF43BD7EDB96" modified="2019-07-31" version="1" fragment="single">MYFGKKLLVCKNSLKYKNFRSCIFIIIISKFLRTNNCISIIVDFENYTPEQACFIDPLISYDKNIDSEGGITDFKQTKSRFLPAIHRSKASIRQDYCKLPIKKRLYNSINDPSSPYLDDIGTCLNTGGVLNSESDTIEKNIEGCTSFNTELDVSGEKQAFEASASSREPIDIVTFDYSDSFMIRSKYLDELEKTEKYQIKLNIRDITKSEVDSHIFRECMNVLENGWNLDFLGIKKEEFLTLIWLLYDLRCYTESDALFILYKNLLSLLLIYLSNSTLPGELNLFYADFMNHNKYFLPFIFILYDNIYVKYDSKTKELSLIEEKKKMMYTSFEEQDIDEIIIRTTPIVLELINKENSKDKLVLLNFIACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRQ6</accession>
    <name>A0A4Q9LRQ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0235p0060</name>
        <name evidence="9" type="ORF">CWI38_1961p0020</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001961">
        <property type="protein sequence ID" value="TBU10180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRQ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1961p0020"/>
    <dbReference type="OrthoDB" id="2190092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="24210" checksum="5341C9CF92DECBAA" modified="2019-07-31" version="1">MKFITSLVVLNSCATEYLMIFLHGLNSNGYEVSKKFCDLANQYKNIKMVFPTSEKRKVGIYNNECVNAWYNITTKNVSMDEDCQGLNESMESILDLINFYGFRPESVIIGGFSQGAAMALYTAMNSYYRFRVVLCFSGYLPCFLSTKNCVEQRIVMTHGKKDSEVPYIFGWLSYGALLVFKQCVKFISFDGPHEFPPNYEDLVLGKYRMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS32</accession>
    <name>A0A4Q9LS32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1851p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001851">
        <property type="protein sequence ID" value="TBU10320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS32"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1851p0010"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14396" checksum="D1BA03BB73ABA4B5" modified="2019-07-31" version="1" fragment="single">MDKTSADNAAKKRIMKEMQALSKEKSDPKNMAKDTTFRCFEIQPSGNGNFFEWDAKLIPPEGSFYHGGIFNLRITFPADYPFKPPKIIFLTKIYHPNINSNGVICLDILNDSWSPALTIQKVIISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS72</accession>
    <name>A0A4Q9LS72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1222p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001222">
        <property type="protein sequence ID" value="TBU11408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1222p0010"/>
    <dbReference type="OrthoDB" id="2191774at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="977" mass="117186" checksum="3F12B6011F0189F3" modified="2019-07-31" version="1">MSIVRFKAHHFRSPNYRYTSLKQYLKNISNHVLSRIDDFFDSNNPSRTEMSDFFENLQNLFLKASQLMKVMEFKREISESTKKIEFLQQSNERFMISADRLAYIFEEIKMTSSYMFDVKYAIKSIFQPENLLPKVIYDFSSFTSQDFKKRLLEYKKSGQNNFYKQNQPEKKFNYLKFKNGFIDSTDKQNIPINSELCINEMERIDLNKKNFEDKEFYKEEAEQINFNKDSCEISFVDSNKNNFKSIELLIKIYLKKEDISSFDSYFIKDGILFLKGNYLTYKMALCGEINNCEWKLLDIETHLRDKRITNLIVNNINGIELKFEEENKKKKSFNSLILFNKIVDANYEARNSYECIKEYVKGTFNDFFVSSFDFYLHCFIKDIIFYKEIEINGKKKRIESDAISFFENTVKSEIKNTIEKVQENILRRNKDSFTTFQDFNTNLNEITEYYCQNIYKSDFTSLNELYLHIYKTTIERHFYEFFIHLSELKNLEIQKNYSDKQFGDKNIFLKKDENFCCFKIESIEEEIYIKIFCGHKKKETDLLFVTLGPENINYENNFRLKTNSESKISFKNISVLLEKNTDLFLMIYTLYLQFNVEIFLENEILFTIENTINVKIANFIQINSLYINSTKIQIIKNFLDYKKLCNKIIIYSMNKKGINYLEEIDQNIKPKKLGEILIYRYIIDSLITVNNGYFVFTITFENGKINFYSENEIINKCVSCKMEHDVSTLLEYLDAFSLFFILKIPIKNIYCNYITIKFNNFIKDSILMKNENKLEYFDILNLNETHFNLNPENLKSSVLLRKTKVSSNFFNFLPTYSKNFLLINDNSKFNFILNLKEQILKDKIVRMGVFFRNYKNIIFDKWFLKCIMEDLLWEIVLIKINKNIAMSNHKLLMDENSNIYDYLISTAFANENAKIENVVYIRFNFCKGIFNELETYELECFFTHILNYDINYLNYLHILVDLEQIKNFLFRILLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS96</accession>
    <name>A0A4Q9LS96_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1451p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001451">
        <property type="protein sequence ID" value="TBU10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS96"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1451p0020"/>
    <dbReference type="OrthoDB" id="2189774at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="891"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="659"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1175" mass="130715" checksum="9DF794F0B855F692" modified="2019-07-31" version="1" fragment="single">MHNKPNPDERKKNLIKLFNALKSSPFSNTHALEQIREAAIKAEQISFEQSKTIEEYLYKMNEKYCKITKMTQNPTHMHSSKQTESNYNISESSTKSSTSSNSSNPYIANPSNPYIANPSNPYNPSNPSNPYIANPSNPSNPYNTTNPSNSSNPYTTNPSNPYIANPSAHPPNPSNPSNPSTPYTDTFSIPRHPLQNNFHPQQIFYNQNNSSYNNSQPLHANIPFYTVSGSRSHLSNINNIKKGFYTGNSNSGANSSVNSINCGVSSSGSANGINSSVNGNNSSVNGNNNSVNNNGNPYTTSNTNPYNTNNTNPYNNTNYNTNQYGSKPNPYTTYPYNNIYPNPSPNPNQCINNTSNNPINTNPYNNTLTNNTPYSINPYSTNNNLYSHINNTSISLSNQLYKQNPNINTEHIMNNSNYYPVFNSNISKKTRYFKSKINPVNVEIKRNSNYLKGSEEGGDNCSGNGYGNNGYGGSINNTPYNSAGNNTSYNSAGNNTSYNSAGSNTPNSNTYNNTPLNTNPYNNTNPNSNTYNNTPYSNTTNNTPLNTTPYNNTNPNPTIINTSNTTNPNTTTINTPLNTNHNTTNINTPFIYQHNTINRHPSIFNEMPEFLRYNDIPQESNKTIKTVKSPVIKIDRQHMYSKEGVKYTEQEIKHNNEINSNNGSYSNNGYNSTVNNTSSTNPYNNTPLNNTTTNPYSNTPLNNTTPYNNTPLNNTSTNPYNNTPLNNTSTNPYNNTPLNNNTTNPYSNTPLNNTNTPYSNTPLNNRIERDIYNTNYRQNISQQQDTNTITSPRKRGRKSKLSPSLKKIQNISSYSENNLDSKDNGVSSSNSSVNMFDRIMGNHFDTTRGVNNKDSSLKGVSSNYYTGNDLYGSNTSTSQYNNTSLFTNGINNTPSTNPYNNTPSTTPYNNTTTTNPYNNTPSTNPYNNTSSTNPYNNTSTSNPNLLNTSQYINTPTNPYNNTSFNSTFISTKNKVVICKKVEEIKEEETWKLQEKNLSRSLTSQDKRVDNIETVTKKVELKVVELSRKEIVEKVLKEIEDLEEEYGGYKDYCGDNDGEDSEGEGEGILTPDDLMDRLIEERRVFFEEGIGIKMVKGFNIIEEGDNDIEDGLEGVSDKDNRGGDISSKEEGVSDREGVLESVSNTIDKLEGFGDKDMLEGVNNTIDYLEGVSNCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD3</accession>
    <name>A0A4Q9LSD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1643p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001643">
        <property type="protein sequence ID" value="TBU10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1643p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="27922" checksum="1832AF1CC15CD80C" modified="2019-07-31" version="1" fragment="single">MFYLYSRFEETEVFDHEVSGCLTNESKHYSEEMILKSDEPVSFILLLENSSSKHLVKSLGFVAQIQDILKKIQVLEKNNEDKMNQNIENIWLSSTIQKYLNETHKITSKANTRNLSPPSSQSYQISTENLRFIQNRGEETDSDLFFIKYIQQWEFVRNIKLEFFKKLFYNTEIKKILSEYLEFQNTENPNTGPDSFIRLESFLECNFEKIQYLFSQNLNAFFDTTFSTTIYSALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH9</accession>
    <name>A0A4Q9LSH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1214p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001214">
        <property type="protein sequence ID" value="TBU11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1214p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="10986" checksum="33FC9316C26D0D6E" modified="2019-07-31" version="1">MEKNSDEILEEQLEFVFKDFPPLTNENIVKGFLNRRVGIGFVMKDTKFDKNFVKNSFLSSKRAKSIKNEVKNEEDSKEELAKDSFVKSKKKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ6</accession>
    <name>A0A4Q9LSJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1168p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001168">
        <property type="protein sequence ID" value="TBU11509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1168p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="50364" checksum="B8BE68B193D2FB81" modified="2019-07-31" version="1" fragment="single">MFLYFLVYLATSLPDQEEFDISEDLTVKENVTNEKYHNFLEYFTTLICYFVYNNDEIENAHKFKPELLFNLICFGKFMEIYKTDRKVKKIVEQMSGDLVAEKNSVWGAKEYEDIEITNQNIYKAISDSFSQEDKSDLELLQGLKILPCENNEIFKNMSKLLSNATFQCFLGFFLVLKCKNFSENLENYEKKNSVYSNISSNFTESFINDSKIEARKLEDELGCGLGINGYYEVWRRILGPIPDRILNEGYIFKDMCKLPRHLVFYQDDPIDSSFPRVFLELFYEESELDNIKGLYIFMKGIIKEDYQKYFSAVICLKITCLKGGIFKSNFIMEIIFEFLFLADVLKTELEKVENIEKIKKNRSLFVDAFKKILDQKKIQYVKGGDSDFLDCSKFPKTAILLEILCYIDLFSNDCFKGLLNTQIHKKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL0</accession>
    <name>A0A4Q9LSL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1198p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001198">
        <property type="protein sequence ID" value="TBU11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1198p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="43141" checksum="61D8B820E26849CE" modified="2019-07-31" version="1">MLAQKKYLFLPLVEALLFSYNINENKGDTKYKPNCGSKTENYIVSNSENNNEYIENKLGICVSSGITDIFKVKKLSLKCKTDMCSRYIMIWNKITGGDFFEERIKDILMKKIEFQTIKYLIPYEIEMITKFLSEIQIKEILSGIKECDSKKYHEIRNQIIFIDNIETKYLIGHDWVLNFIKKYEKSTREDLRVLANSCYAKLLVKEKRFKAEIEANESVITPKGNTSYISDSDSVPAKNLRKNSSSSEEGELRKWDEEENKLARKPENIIARPDTRKFERDSKPYEHSIGDRYKYRYQSEQSTYRSGFGDSKSVYSRNSYSYKRRYDDDCYRYKNTRGDDFYGKNRSGDRNISDDSSEYSYKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN0</accession>
    <name>A0A4Q9LSN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1188p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001188">
        <property type="protein sequence ID" value="TBU11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1188p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020696340" evidence="2">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="358" mass="40094" checksum="43E4A881BACB8A7D" modified="2019-07-31" version="1">MKYSIFVQSFVFLGCKVLGTTVKYSYAMQDSQSDPSDGSSGYFNLSSNGKLTETFCSDSTTSSALDNKDPNTDYKNSYCNFYCSFYKSDPAGYYNYYMKYYGQQPNYSTTGTNTYTPQSTPQQYTQPSTQQYQQQYGQQPAQQPAPQPAPQPAQQPAQQPAQQQAQQLAQQLAKKIDQQQAQQPAQQPAQQPAQQPAQQPAQQAQQLAQQLAQKIDQQQAQQPNQQQAQQPAQQPAQQPAQQPTQQPSQYQYTQTSAQQYQQYAPQQSFAQQKELAKYAHPSNVNSYCVCDNSSGQKNGMSYDMMKVFNDFLMNTSSKGSICNCSPSNSDGVILNYDLNDGPYMFVDHGNTSYKCTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP7</accession>
    <name>A0A4Q9LSP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1119p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001119">
        <property type="protein sequence ID" value="TBU11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1119p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="353" mass="40814" checksum="23AA9EFC84F583F7" modified="2019-07-31" version="1">MIVRVLVIRSRDIRGLDDCKGVSDKESRDIRGLDDCKGVSDKDKDVLEGVSNKEYSYRGVKGVSSKEYSYKGVSNNDDKEYSYRGVKGVSSKEYSYKGVSNNDDKEYSYRGVRCKVIRSRDIRGCKVYTKDVLEGVSNKEYSYRGVSNKGLRGCKVLIDDYKGVSVKDMKIKILKNTLNFLIFKYKEIEKNIFQSNFSVKRYKEVVNIYKGVSYKIESVNTSILNEIYKLFYRRIGRECNVYNGITIYECGNKDRNIGQVDINLDINLDTNLDTNNIERNIDRNIEGNIERSIERSIEGNKYITNEDYNIERSIEDITECNIDFNRFVEFDVNDEELKIGGDNKSRIEGVNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT12</accession>
    <name>A0A4Q9LT12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1614p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001614">
        <property type="protein sequence ID" value="TBU10680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1614p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11787" checksum="2D5001776FF3734E" modified="2019-07-31" version="1" fragment="single">NAEESWERASMGVIMRAKMHEELKPYLKEEKREEDGAKNFKPKNKAPFIPQGRTTLEEPTNNINKESDIEEERKWLKKWKKTYKNRKNILTHNIINDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA1</accession>
    <name>A0A4Q9LTA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1239p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001239">
        <property type="protein sequence ID" value="TBU11376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1239p0010"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="656" mass="77234" checksum="877FC259C1A60DD2" modified="2019-07-31" version="1">MATKINSEVGKFISFYREKKGVETKDLYEHQRNILLKRKLKNGEPGYGNLMILLFLAIAEGKLDYMEFISACGLKKLDIKIIGYLGANMVKDNFYNLMMVNTLRKDLASENYNDLSLTYICNLIEIGEQFKELKDLICLKSTKDITFCKKLIAISRLQDKPIVSKLIMGDSNILHVKLQILIDYIFCLKEKLDCEKSVVYPFSKNSYQNLKNSENSIFLDLCENDILYLISLYPRTTNINLKIKILQLFSSFIDKFNFNELYKLNENIEASIIVTGFLKKTNLEISLSIESAIFLFSIGYQSVVANSFVFRLIESRMSLCTYYGLYFARKFRIFKEVAIERCFSIGLHKYECLETVLDLITKANYLEIYKRKEEVFLIMESNLVKSDICHEKWSKILKKILKIADQEFVFKIFLENPYINNSSPVYEQLNEKSLPLLFEKIKEQESLEYFDLIYTLLPYQQNESHVLSQIFEKHLNILSDYQNKNFSKRIYKNITKNLINQMLKYGDLDYNRDIMLKHMNSYNNKTYNITTNILREYILIFNVLVDKKVFWFNIENIFEYEVLNTTNLTENKNNKFNTIKNELKKEFDSSNNDLKLIYLTGKEIDRLSFFCEDISVIMNLIKISEAEIIIQVEKNTKVLFAKQKNNDITTRKILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA6</accession>
    <name>A0A4Q9LTA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1163p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001163">
        <property type="protein sequence ID" value="TBU11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1163p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021003666" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15557" checksum="F2DC86F10A7421F1" modified="2019-07-31" version="1" fragment="single">MKIFGFLTLFLLIYSTVKSNNKKSKETKKIEVIKSRNHIPDIVIYNDKDSSIYKRVFNQLYVERLTIYFSEIFNGYLNERTYTERILPKLKNIASKCEKITDSKQKHEEFFKMVASFARTDIIHCKRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTB2</accession>
    <name>A0A4Q9LTB2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1549p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="PITK01001549">
        <property type="protein sequence ID" value="TBU10790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTB2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1549p0020"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="130"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="31063" checksum="294F4E78478EF981" modified="2019-07-31" version="1">MLLCILGPKKSGKHAFTNYLCNLSYTYIDYSPDLSSTLICESKWNKSLVTILPDPESWLNLRKRPFVHLIIIYAPSKSIWRNSNDDSFFLKVLNLKLDKSITQCTEIPNYSTIESLFSFVSTLDFNIRPTFDKYFMDVAISVSLRSNCMKMKIGAIIVKDKRIIATGYNGTPKSMLNCFEGGCNRCNSNVGNNKGLTYCVCIHAEESALLNIGYERCVNSYIYVTHFPCQLCFRKIVQMGIKKVLYRFKYSLEDDIVNDYFKSSDIETESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU72</accession>
    <name>A0A4Q9LU72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0998p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000998">
        <property type="protein sequence ID" value="TBU11877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU72"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0998p0020"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02890">
        <property type="entry name" value="PTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="36758" checksum="7E52B1EB549091C5" modified="2019-07-31" version="1">MRADKNFNTEIHKRFIIKMLKENYDQEYESLAVWIPYWCISSLILLDSYRGGVCNIDFKSLEFKHLGDKILKCHKIYFSNKITPHLCNVYASICTLKMLNRLEEVKKDEIVKFMWNMKNEDGSFSLYETGDSDVRGIYCSLAISRMLTDINTTGLFLKSKEFILECQSYEGGFGSIPGGEAHGGYTYCAVASLIMMNVLEECNIPLLIEWLSNRQKDFKGGFTGRTNKNQDSCYGFWIGACIKALINLGKMNISQININSVKDYVFKECEDIKNGGFSDKPGNTPDCHHTCYTLLFLSIFDTENMFKVNVDHTLGLVEFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB6</accession>
    <name>A0A4Q9LUB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0833p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000833">
        <property type="protein sequence ID" value="TBU12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0833p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="32382" checksum="754C54D6EB998E62" modified="2019-07-31" version="1">MFFHIFICLAASSQEINLCSILLDLTIDENRHLKLSYSIMADETELEELPKLQVFFSKKIKQHTSEEFHEFLTHFTTLVVVIVYNSYSERNFKEYRPELLFNLICFGKFNIKKIVENIFGNFLVNELSRLGVKSYEIKNAFTTLGINMNAQFNEEQPIIENVLINQNEFGEIFAFSRDKTTFQNSLGDGDDPRVSIETLCRKSDVNNCNTLYEFLKEKTKEEYHKYIYIIISLKILSLEEATLNGCNISKIIIEFLFLVDVARKELGMGENTEKPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG9</accession>
    <name>A0A4Q9LUG9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small Rab5-like GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0224p0020</name>
        <name evidence="4" type="ORF">CWI38_0483p0010</name>
        <name evidence="3" type="ORF">CWI38_1317p0020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000224">
        <property type="protein sequence ID" value="TBU03835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001317">
        <property type="protein sequence ID" value="TBU11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000483">
        <property type="protein sequence ID" value="TBU13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0224p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0483p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1317p0020"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="196" mass="22496" checksum="2ED628A6FB6BA046" modified="2019-07-31" version="1">MKTDIDIMEYSYKLVVLGYYSVGKSCLVMKYVKGEFNSNEESTIGAAFLTKSLFSNGASIKYEIWDTAGQERYNSLIPMYYRGAHVAFIVYDITSRESFETAKKWVEELKVEKPKDFIKILVGNKMDLCSLRKINYEEGKTYADSQGLRFYETSAKTGHNVKKIFFETAELLPRKEVEPKIAKINIKGGKRNFSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ8</accession>
    <name>A0A4Q9LUJ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0936p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000936">
        <property type="protein sequence ID" value="TBU12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0936p0030"/>
    <dbReference type="OrthoDB" id="2191709at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="91512" checksum="BC1859426E640773" modified="2019-07-31" version="1">MHESKNCLDEVKAVLFSLVASIKVDIDKESEFKAILCDINTILKTEPSLYICLVEWKFFTKQFIYILREECIFIESMDILVNALEYFVQSKKKNNLKEFFINRNNLIFLSEKIYKTLKNIKTEFNENFIEEDLLWRCSESKIITKVIHSLKLFISLNDNFTVSILLNILMEIGFFDLILFLKTETVCDLFNQIFKYKSCFKSKETTISDKSTVPYENIRKHFDPEIFYSLKDNIPKKSYFSKYCFISNPVFIKLAKMIYQYVFYFLVEYFSIPRNIHTINFICELKFTGKLEDIENLKYKKLSTSTEQIYDEIESASRINFLNNHDYKENSYFSVVHDNSDNLSENKYSNNETLNLFNYRDFQDHSVHEESMKIEVNSNFENKDISNQNIYDETISQTLINLPDKIDVGLDHLINFNSVLSRITELQNELKSFPKVCYFEIYINMLELIRNHSQKQILIRKVFQNTEFISKISAFITDKNLEISINSVKIIYNHYVLLKEFFDKNLFLYRGNSKLEKNNIKDLFRCLNKEKKIQRMFTLLQYNCKCVSGCNYSNCIYPRVLIVLGNTFLNGKKEFFYKPSNLALMWSIHNFFPEFADEKIDTFDLSNFSCFFKIYFEKFMNFLSKNPYNYAKILFPIENKKIEKKEAKFNVQIDQDEAEFNIKNNDLISSSEEEQTLEPYNSKSKIFDNNFFESVIFKEEKNELKPEEELEKSTEKDLQNEIMDQKNTKNNFTSTNFESKQEIEESKINSKKKKIKKSKYNLESSSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL2</accession>
    <name>A0A4Q9LUL2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentapeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0829p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000829">
        <property type="protein sequence ID" value="TBU12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0829p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="28018" checksum="8A47E63B16DDB363" modified="2019-07-31" version="1">MILEVIYPEISSKSIIYDYIDMLDELKNLRLQFENKLAKNYILSQFKNRNKKMLINFLFSDHSISKYDILELSFLTESKSVTLEKVNIIGSIVNSFQNCKFNQIESLTFKYCIFSTPDKESIRCKNLEYIKFHRCKFDNINFSNLFCKDIRYKIKKFYMNESQLTDKDLIWLCSLRCLVYMSFFDSIIPYNALLKFKKSDFANPTNLKLNLFQYKNRSKYKNHIYEEFGLIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV29</accession>
    <name>A0A4Q9LV29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0720p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000720">
        <property type="protein sequence ID" value="TBU12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0720p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="33348" checksum="E6679F77F5DFB776" modified="2019-07-31" version="1">MFHILYSQIFCITIGRKVIFRQIFNPHKTDEHINSTETLIYTVESNILKFNINEKHFERDSKVLLDFCDSKDIIIAIIFDIEKFALNFKKIEDSDASINSENSIKVLKVETFAIKKFELFLSTYYLHQKNISIKDYLNFIYFFEVIGVEFDDKYFKTMETLAVSLLSVENFDSSDFEEKINNVFTIDLISRESSFFVFKTTFDFLFVDFKFKNFERFYGSNHLNLPTLIRERFITRYCNTLYLNEFSLPIYFDEGKYSKIQRNIIYLILYILNYKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV32</accession>
    <name>A0A4Q9LV32_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichol kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0055p0020</name>
        <name evidence="3" type="ORF">CWI38_0176p0020</name>
        <name evidence="2" type="ORF">CWI38_1103p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001103">
        <property type="protein sequence ID" value="TBU11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000176">
        <property type="protein sequence ID" value="TBU19904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV32"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0176p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1103p0020"/>
    <dbReference type="OrthoDB" id="2190004at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="37826" checksum="F880ED17F377F1F6" modified="2019-07-31" version="1">MKIFHQKYILENLIFLLIISYLWINVSLVEKIEILVNILYLYFEFTDCFKNIEILIISYCLVKIEQKYLYKELLYITFYHQCFLSMFSTNIIYYLIYILLIFEIPIQIFYICVDLVLKNFGKLFLDFVFTLIFITLQYFVVSWNNLNFRRKLFHFFLFIIFVTIDGKFDILFEILLFLSVFLTTNKCFNYISRKYKNDKDNGIFPVSHILLICSCFFPKFFISEIRQYEAILICVCILDSFSSIGGLYFKSVDKSIIGSFFGFFVSILLHYLLQNTFEFFLYFLFMSCVEYLTTFNDNIILPFSSILFFNFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV42</accession>
    <name>A0A4Q9LV42_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tub-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0718p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000718">
        <property type="protein sequence ID" value="TBU12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV42"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV42"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0718p0020"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="29824" checksum="1F065FD134E4A883" modified="2019-07-31" version="1">MADDSSFMSPDFSLSERNFEELNERLTPATENEVYLSHKNIVKNHPKMDVIVKGQVVREKKYFRNRYFYEYENGNNTRNRLLKAEKTFFGFNIYSYSGNTTKLCAKLSSNFTGTTYHLYELEKSVPETMIVKYNMCLFGPKGPRSFCVAFGGIDNFENKSISERWRERDLSSIIFLCNKKPVFNAETNSYVLNFNGRVTMPSVKNFQLIHPQEPSYITLTFGKILSNVFVLDYQYPWNAIEAFSIAITALDFKIGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV48</accession>
    <name>A0A4Q9LV48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0883p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000883">
        <property type="protein sequence ID" value="TBU12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0883p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="24559" checksum="8860D26F53122AFA" modified="2019-07-31" version="1">MYNSLLSTTRLSTFLAYILFTGFIRTYICVRITINFTNESCLKDVVPDQGESHIASNSHTITSQVSELDSVSYQNQISFDPILKHTNEERTEYPYNTYNKRPRIDSCAESEYNKESIRMDKTSMPSYRDSSTNEDKTINTNLFNIRKEGLFVDGMARCDKNNLIQHPLNTLTFDYSDNYQIKSRYFDRFNKPELNEICLNIKAITKSNIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD4</accession>
    <name>A0A4Q9LVD4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0683p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000683">
        <property type="protein sequence ID" value="TBU12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0683p0050"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52257" checksum="7C624EFA700D2B44" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAENDADDVKKSDSGKQKCELDPPAISLPSSSYTTITHPPPNQTCSNMQNSGLDTLPSPNTPHPSSVEVSACEPSLMALRTILDSVTADLMEWPRIVFFFLQMPRNGWPATLSEIIQEEKEERSISLTDTSEYINLRDKFLSKIKEISENEIGKVVVRTRKLPILELNNRIIGEYADSCVPMTINAVARIIQAAQVCYDEATRKEKPRFAWKENIESKISKLLLSKDLLEKARRQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHENNHPTTFPSLDEFVNIINWLLNRKSAGIDGIYNFFIKKLTTLHKYNYDIVKFICLEETPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQLEVEKRGLLAQNQLGAGRGVQGAKEQALLNIALNKGYGNNLKATWIDVKKLMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVI6</accession>
    <name>A0A4Q9LVI6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1030p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001030">
        <property type="protein sequence ID" value="TBU11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVI6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1030p0020"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="2">
        <location>
            <begin position="218"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="477" mass="56717" checksum="C371548B7E057432" modified="2019-07-31" version="1">MNFNTENKTKEMKSNSSEDRMYYKNNKYEKYYSQEDKPTNRYEKYDNKYEKSYSQEDKPTNRYDSNRYDNNKYEKSYSQEDKPTNRYDSNRYDSNKYEKSYSQEDKPTNRYDSNRYDSNRYDSNKYEKSYSQEDKPTNRYDSNKYEKSYSQEDKPSNNQRTNNNQISNNKPTNNNKPTNNNQISYNKLTNNKPNYKKIISRTELLALKEAESKRNKELLDLETINEIIISRDYLLENIYKPHFESIIGSYVRVCLEESYYIGKIIGISIGNKIYSSIYQGRKEVKTNKYLKVMIGKKVYDKFEVTYVSNSKVKELEFGIFKGDFKDKNICKGDFLIPYFDIKKKIERVMSDLEFTKMLEEKHKFHPREKSMTVKKIELITQRDNAINGDRDFKKAAKYQQMIIELEDEQFKDNPGMKKEGKLKVGEKGVSGKEEGGVSDKEDKEVVYVSIEGGVMNSTVIKRWYHSTVIKGGYLQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM3</accession>
    <name>A0A4Q9LVM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0761p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000761">
        <property type="protein sequence ID" value="TBU12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0761p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7261" checksum="43AA7882BB860093" modified="2019-07-31" version="1">MNIEAYIQKKVLNKTSRPNEKKSLEEASFVLQGATKKEDGGILDVVVRTRKFPSELVDSRILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN4</accession>
    <name>A0A4Q9LVN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0677p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000677">
        <property type="protein sequence ID" value="TBU12664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0677p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020872822" evidence="1">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="441" mass="53153" checksum="F5EE1A4658EA5A48" modified="2019-07-31" version="1">MIGSYLGTLLLFCSFVSICLSSNDLEEIYDVNENKEFFAKKSLDLYNKETKRLKMLPKSLDFAYFMFYDNSLEVVADSISKYFKTKTANKYDIKIYRPDFKTNDPFQTVVFQLFRIKRIYNTWYIVDIYVSKNLPRNKQTKNKNIILSQKAFGIFLCNFFHMYKFIKKICNYPDNYDDSFILIEDTGNNIRKKNPKKYQKLDTTLETGIYNIFCLKMFSEVENFNCELNENKMIRKFNKIFGEITCLLCGYYTVYFIEMNESESVENICIKKIFKTTKISLFRIALEVESLPLANKNSIFFLKKKFRFESSIHRTEFEYFYSIYNVNDKDYKFKIFLKHSDIAFEFNFNWIETQLKKSYIPNSSIYIYVIRGDKLYILEILEDTNRKYFKIKKANRPCACLHFDCKENIKYLNKNYELKELLNRLVFSNEIDIKWYFQKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW32</accession>
    <name>A0A4Q9LW32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0704p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000704">
        <property type="protein sequence ID" value="TBU12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0704p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="21181" checksum="6911371CDD50D887" modified="2019-07-31" version="1">MFSVHLKKRIFGTLITFLVLIFKREIFDNKKMDIKEKSVSYKYKLININKKNINEIYIGDWLIIIDYKKRKEHVFYSNIALNVTNVGFICVDTLQEAYIATLFKPSKYPSFFWIKNGKCNSFTDEKSMDILLVFDYFIYSKMIVICHIIKSFIKENLHIIAPMAFTYLHYLVSLLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW45</accession>
    <name>A0A4Q9LW45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RCC1-like regulator of chromosome condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0988p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000988">
        <property type="protein sequence ID" value="TBU11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW45"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0988p0020"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="381" mass="42307" checksum="CE05BEF39EB7D329" modified="2019-07-31" version="1">MPVYVFGSNSISQLGLGTEIIKSKPLRLSFFDEIKIKKVKCGVIHTLLLTTDGKLYSWGCNDECALGRDGDESIPGLVNIPEEIVDMAGGGSISVAISVKGNVYAWGTFRNESGVLGFTVDIKIQKYPLKLKLKNIVKVECGFNHVLLLTDKNVLITFGVGICGQLGWKVSKRNKNCLIPTTISTTRKRKINEKFVDIKCGSSHSIAINSDGEAFVWGKNIYGQLGLNDRNSIYKRQKVDLKNIVTAEGGEDHSFFVANDYNIFSCGRNDLGQLGLNDKLHRDIPTSINVIRKLKVKNISKNIFDSNNYEEISNFQIQKIRSCGHFTIIQIENTLFSFGFNTSGELGYDCETSNLPTEIDFDFGNILDFDVGNDFVVVLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW63</accession>
    <name>A0A4Q9LW63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0914p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000914">
        <property type="protein sequence ID" value="TBU12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW63"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0914p0010"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="566" mass="67370" checksum="E01FB96ACD823DBF" modified="2019-07-31" version="1">MKYPIFYATQSGTSYFISKTIASTLNNGFDRCSVAKSMNERTFEPFSINNFDITKIIYLKLFIIVVPTYGDGDHSFELFKFWKIISMEEIPKIFKNKYFAVFGIGDSSYEKFNYSSKKIYNRIISLGGIPLIRRGNGDIGADDGYNSELKNWMFELMNNICNIFTCFSFSYGLDETKIDCLLNLNRVFKDFQCKNLNEINFDLFLETNTKYKSKVIHKEYLTPSDYDKEVLEIIFEINEYTGYKPGCCLEIKPTNYNYLDFIKYNNFNGNEMIEYKNTKISVFKLLRKIKDINFVPQQLFFYSFYTEIKEIYGDNKLFESKYNKNLECKEIIERIKIISQDYDLYHDYVLKPKRTFFEILIDLELKVSLNFVKVYFPEILNRYFTFEHKKENKYSIAVSLIEYKSIIRTKRYGLCSKYLKDLSINSEIFIGITESNLHLNGNKFLVICTGTGIVVAKSILNYFKNLEMIIFYGFRFLEKDFLFRKELFENNELNEKWIKNKNLKMCVALSREMDRKYVHKIFEEEWNGNIEEYSVILAGNTSLNKEMRKTFFKMFNKNIDFQSETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA7</accession>
    <name>A0A4Q9LWA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative inositol hexakisphosphate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0580p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000580">
        <property type="protein sequence ID" value="TBU12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0580p0010"/>
    <dbReference type="OrthoDB" id="5322816at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020851643" evidence="1">
        <location>
            <begin position="16"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="34064" checksum="224914F0EEDC5C8B" modified="2019-07-31" version="1">MNLIVINLILYFINAEKIEYCVSGEQKRYIINSPPKLKNFRASLLKKFPVSVSIEKRQKELKNKDIKDLENLNISGSAQPNILQLTSLLNILNTLSKKIIFVDLRAESHFFISPTDNITLDCKKYDEDIINQEEIDTKDFTEPYHVVMTYNRKEKKVVKVEDVITEKKFVERDFSDTVEYYRMPIKDHMAPDRDILDKFINFIKGKPKGTYWIHFHCNGGKGRTTYMMTIMDILINGKNSTLDEIIGRMYLLGGSDMSEFNDKHKNQHYKRYQILKGTYQDIIKKKIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX76</accession>
    <name>A0A4Q9LX76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0583p0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000583">
        <property type="protein sequence ID" value="TBU12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX76"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0583p0050"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="21479" checksum="999AB46D9200B0BE" modified="2019-07-31" version="1">MIKSLYQRLLIKRARVLVIGLEHTGKSSFIPLIFNDTFEDNQGPSSVEIKRYAFSGITFVVYDIPGGRDSIAKWDHYYKKADLLIFFVNSAAQEEELAKSRDELKNLLYRNMWLKKSILILGNKNDLDGSISCKDIILKLDLLSIVDREVACYSVSGKKNINTDLVRDWLVEQTGYLSNRRYYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF1</accession>
    <name>A0A4Q9LXF1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0765p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000765">
        <property type="protein sequence ID" value="TBU12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0765p0010"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="20819" checksum="B0A9E4FA80C243FB" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPECIECENDNVLKCLVETSGSHDENLSITTIPTLRKQKVSINDRERIIEKTLEGYSMSAIASMYRINYQTVNSIVRRYLKTGLVFVDKRGGDRRSKLTLEIKESLQAYVDLECTKTLYELAEWVKCTFNIDVSTSTIDRALGEFHYTIKRVTVVPERRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH5</accession>
    <name>A0A4Q9LXH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0420p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000420">
        <property type="protein sequence ID" value="TBU13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0420p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="17718" checksum="E66E92CF14220725" modified="2019-07-31" version="1">MPKGISGIDPSDNIDAIKLSLSDNQKWMVFEFNTGYMCRANSKIGVVGCANKKENSKWMINKTDRGYSITYDTKMCLIKGGFDNRLTSMGYFVKLGKCETVDDDKYFLIEEISSRSKFSPSGYKKSLNKDSIEDKEHHMQDKYCPVLGTTHKQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH0</accession>
    <name>A0A4Q9LYH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0304p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000304">
        <property type="protein sequence ID" value="TBU15965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0304p0010"/>
    <dbReference type="OrthoDB" id="2194544at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="292"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU15965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="517" mass="60775" checksum="74AFAECC6C2C6BFC" modified="2019-07-31" version="1">MNLLLGNLDFVRIFLDDILIFSKNTEHHKLHVKEVLNSLKSHEISINFDKSNFFLKEVQFLGYLITNNTLKPDISNVDHKRINMPYPTTKKHLLSLIGYINWFRPFVYNISSRISRWNDYLKQPQFKWNKEDIIQLESIFNDISNPKILHIADPNKPFMLFTDACDTGINEYNFKLKFIKGEENENIQESQQNSKNIMTQYSYDIANLKEKYLYTDLNHKIIVPDDISVKVINQIHTMLGHCRINKLYYSIKNFYLISNIKGKIKHVVSTCSTCMINKRQTISYGKITGFIESAQPLKKICSDILGSLINQFDKRKFYILTITDDFSRYTLLTILYQISTKQVIKAFENWFHRFKRPKEILTDQGRQYISEEFNTFCRFNGIKHICTSVYNPTGNSILERANQIISSAINIAEFTLNNAYNRITELSPEEIIFNKSRLDLLERTRKINLESIATRIKQAADSENQKSNAKRKTEFVYEVGNFALVKNHNRSKLDPFYIEHKEFEAFSDRKQLVVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYM6</accession>
    <name>A0A4Q9LYM6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0292p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000292">
        <property type="protein sequence ID" value="TBU17005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYM6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0292p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="29723" checksum="8A3244DB3EF526AF" modified="2019-07-31" version="1">MSKNVAIKLLIIIVISIGLTLFVESHYRAELLCEKMEGIISESKISLEDIISMVDCLKNKVGIVVKKKDNKYYGVVCRMKEESYDKTETYMENSFSYFQKQEKKLDEELDKIKARKDEIQRDPNEATVYFKEENTLKYIWNFDKMKDFYEVIQFDFLTQVGLKTTLKKSNGNVFLQLLNFLYKYINSSKDKYIIIFLEANENTLSVSIGIKTNKTDEIKEIKNFIVQFEGTVEGHNHFSEKALHKLVELPLLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ12</accession>
    <name>A0A4Q9LZ12_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MCM7</name>
        <name evidence="13" type="ORF">CWI38_0375p0040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000375">
        <property type="protein sequence ID" value="TBU13636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ12"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0375p0040"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="322"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU13636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="696" mass="78755" checksum="0934EF29F1AC8CE6" modified="2019-07-31" version="1">MEELKRHQTDINYTADIDRLHKFLLFYTEDTTPKYLLLLRTNTSNLKIHLTDISLYDDTNLTNRILNNTFTYISLLYKAIDNILYNENEVLFNDEDDIFLYHRIARLKERQPDKKVTDVFPSLLLRNYHITLIPPSNIFASPLRHIKACDIGKLIKVRGVITKASQVKPIVRVATYICESCGSETYQQVNSDTFVYLSECPSERCKIRKVKGTLTLQSRGSKFMKYQTLKLQEHTYDVPQGCVPRNITIECYGDTTDQAKPGDTVTISGIFLPKPFYGYKKIKAGLLTDTFLYALEVISNSNNSSITDTNIISSYSINPSFTVTELSQAIAPEIFGLSDVKKILLLMLVGAPCNVRSDGMKIRGEINVLLLGDPGVAKSQLLKTVIKIAERGVYCTGRGSSGVGLTASVLRDKSTGESVLEGGALVLSDGGVCCVDELDKMNEVDRMGIYEVMEQQTVSVSKAGINCTLNARCSLLGAANPVRGKYDTKKSVEHNVGLPCALISRFDALVVLKDDPDVENDMRLASHITGIFMGNEIESTVDYQKLQNIIKASKSIFPVIPNSLLERMSDIYVEERKDNNMITPRYLLSLIRLSLAHSRLRMSQIVNEEDVEEAVRLMERSKRVLKREKKEFIHPKHEFYNMVVNMFKKSEIKEMNIEELKSCVAFKFKNENVDLFIEEFEKVGIWVVRDNKLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH4</accession>
    <name>A0A4Q9LZH4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0513p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0070"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26993" checksum="A1A7876E3DA9D377" modified="2019-07-31" version="1">MCQHCNKFGKTVDHLATRCEKMLGHDYTRRHNEVVRCRHLLLLNRYKFKSSKRIRSHTNKNCLKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSIKTIPYVMTWDGIVTKYHKSHLKRLEIPKNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREEDEEPTNNINKESDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZN6</accession>
    <name>A0A4Q9LZN6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0336p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000336">
        <property type="protein sequence ID" value="TBU13805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0336p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="631" mass="75107" checksum="8E08DEE414D8B7C9" modified="2019-07-31" version="1" fragment="single">DTDNLEEYVDLIDKNFLLKYNGTLKFPMKLIHRVFTMNGKNISENFMVEIWDLIKNLKIGERFKLYNSLRIIDNDASVNTRKFLKRLCMDNIEFISKKLIDLCASSPFSVIDEIFKSFITFNSLIPLYIELIKCMKEYFIDFFHFYILELLNNSDYENFECYDASEEMDLFNLERKNTYQGIDNDSSINISDNKKCGAEKGQNENIKTLNQSNTSIHKSKKVVENNEFKKIYTNGEYYQWFTNLCFFLRSFSDLIDRKLFLEYSSTMLAQKKYLFLPLVEALLFSYNINENKGDTKYKPNCGSKTENYIVSNSENNNEYIENKLGICVSSGITDIFKVKKLSLKCKTDMCSRYIMIWNKITGGDFFEERIKDILMKKIEFQTIKYLIPYEIEMITKFLSEIQIKEILFGIKECDSKKYHEVRNHIIFIDNIETKYLIGHDWVLNFIKKYEKSTREDLRVLANSCYAKLLVKEKRFKAEIEANESVITPKGNTSYISDSDSVPAKNLRKNSSSSEEGELRKWDEEENKLARKPENIIARPDTRKFERYSKPYEHSIGDRYQYRYQSEQSTYRRGFGDSKSVYSRNSYNYKRRYDDDYYRYKNTRDNDFYCKNRSGDRNISDDSSEYSYKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT7</accession>
    <name>A0A4Q9LZT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0321p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000321">
        <property type="protein sequence ID" value="TBU14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0321p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="759" mass="90511" checksum="4D89A07B86B3E50B" modified="2019-07-31" version="1">MCNTHLGKTYRNKKVGFWSFVIFVTFKIIFTQRTIAMNFFENVESVSEKNELSNCIYSDICFDFLRVKPKTFIVDANIKILRTFIIDLDNFFLKFINEEKIEENQHNNIYINTRLLKYDDFEYFYKLVMGFPVFIDKMNEGNYLKIFGIIDIFKFKKNNSLKEFIRILWISIVFNPKSFEKRDYASTVANKNIFSSFISKISILELLRLYIIGEATLNKIDDNSLVKTLLDDFNFDFINPNKDYLYLDTDIISEIQKNCTKEVEFLRHIAYFFRNHTFKRIFFNKIFCTAKHNYFFNFSLFEGTNEIFLLRCLNVDVLIQVLRIHSLRNIKTINILNCNFTTQNIISWSKTFYFERLNFINGKDKFKSYHYDSDLNPSLRNIISKFSETMYIENKSNFFVVDKRQIILESYYDESKIEELSSLEGLHKMFIPMKLSDLFLAFNFYSMNFKEFKNIEISFTNMHIKDFNLRESEILNNILSMRIVNSTVNSIFLSKILLFPSLKTLIFYISRICYQKDEAIFNENKKIESLYFRNSVIEDHICFSNFLNSLECLRTLEIISLTKNTNPFISNPYNIKMNLYSLLSLKYSSNYNCGNDIPFFQIFPNIIEFELGLCYPNGTIHKIFFDKNFDSLIKLTFDGVKIGKKDKDALKKCTNIHVLRFTRTCKISEILFAELFNTNNMYSLRDLGLPDIVISILDLQFISKLKFLRKLQIYNFKITTDIMFCFKTFYWMETSENKNLMVSKNRIFEELGIRYEEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M001</accession>
    <name>A0A4Q9M001_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0302p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000302">
        <property type="protein sequence ID" value="TBU15973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M001"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M001"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0302p0030"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="4">
        <location>
            <begin position="105"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="6">
        <location>
            <begin position="369"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="575"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU15973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="865" mass="99019" checksum="2D4615A6CBEE2932" modified="2019-07-31" version="1">MEEQVLNTEHTDGIRLTWNKLPIIPKDTTLPIPISVLYSPLNPSPIIPHEPLFCANSVCRSVFNPFCKIINNQWTCILCNTINNGVIPTSTTVDYILNKVVPEFMYVLVVDMCTFDKERHDLLVEGVRSTLESLPLYSKVGLILFGTNIELFEFSCSVKKVYLFSGKKEYLKEDLQNIICGGSVSKEVGGNLGNLNCFFTSPEKMAMNFIKRDPFPVLDGNRPVRCTGSAISLAVSLLSFCVNDTPAKIILFTQGPPTFGPGCLASLSLSDNIRSNNDILKGKADYYKKGIEYYNKLGHRMVGIGVSLDILAATLYDVGIEEMRGMTDMTGGCVVMAQDFDKEIYISSIKKLYSLHENETEDLHSPKYGFNARLKVLSSKNLVFKGVLGLGASQPSTHKINYLRSTTNLTLLFENGVVQAGEKGFIQLLMQYVRPDGRLILRVTSLLREFDDSHSKDVKESFDQEAAVVLISRMISGVEDDMDLIRRIDRGLIRFVKKFGSFIKGDLESVCLPDNMVYYPNFIYFLRRSLIVQRETSSPDENAYYRNLVMREKVNECMTMIVPTLISFHYQGEIKPVEMDSKSLKDDCILLLDTFHNVVLWRGESIASWIKEGYHLKEDFKYFKEILDEAETKAKSLVNERFPTPQFVVCDRYGSQERILLAKVNPSLKNSVVVTDDIDFETFYKHLCKIVQLLIFRDFSGWLRKGSVRLRDETIFCYTQYIHIRRRAEDNLATRFKYSLHDYNRRHNEVIRYRHLILLNRYKSKFSNRIARQSVQGIHDNEYAGKRVDTKVKTDPNSGYVFRTSLIPMNIERCIQWIQAMGLIKGAEIHKQPKTSFTYVSIEEDLEETTIIMIEEIVQMAEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M070</accession>
    <name>A0A4Q9M070_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0425p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000425">
        <property type="protein sequence ID" value="TBU13460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0425p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="625" mass="73544" checksum="EE7171498569393A" modified="2019-07-31" version="1">MLTCLSLLKATKNKDYDEFIRALIYKNLISKNIDTIFKQESLARIDVSMKKDNFISAVLDFFMIKYDFYDGNLILLDKKKDIYDVKNFDKHIPYKNLFFNSFKIFCRLEIILGNFYASNLFIILLNELNIKSLIISNKDNYKILDKQFNFHILSTKIFKSIVIINFKDISSLLFLSKLNLAIPNNIEFLSFRNLVVPVNILNSFLESRKLIGLVLNEMKFTGAFPFIKDFYDSNETLEYINICYADINSTCWNNFFSRTNVRKIILSFSSSSAEACFLKEFYASAPYKSVRYIEVRFHRASVISKKILEFLKHFTILELLKLHGYIIEKNAEFHIPNAIECMKDLEYLEISQLNYNPDFYNFLPGKSRISVLHIYNVLLDKEAPLIDFIKNHKSLTELDLRETVITKSCLQEIFRLEHLKTFIMKSCVLELFMDDLLLEFASKRLNTLCLSHIDSNYIKYFNFVTKLDCLEYLEILNNKLLPGYLPNLSEKYNLSLKKLSYISTILNEDIMNRMGQLGVLNELYLSKCSFIYTHFHKLGNFCKFFNSLKILDLSCVELNIEDLNYIKNFKKLIKLSIKMPDFDLIPLKNCLILLPNCQLQIFYGKQKGNYDIIRKYLFEQNVDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S4</accession>
    <name>A0A4Q9M0S4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0117p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000117">
        <property type="protein sequence ID" value="TBU20185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0S4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0117p0020"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="443" mass="51205" checksum="65767C75FEFE6EA5" modified="2019-07-31" version="1">MEFTKLEITENIKYVLNENGFSNSTEVQQKVIPLFLKKKDLIVKAMTGSGKTLSFLIPIANFLDINTSKVIKCIIIAPTRELANQIAEVVKMFKSVSSYILIGGEPIENDLKIIDSSEINTLIVTPGRFNEIINLRPEKFKSVEYLILDEADKLLSIGFKVSVLNIISKLPKNRTTCLFSATIDKSILNFTKLNLKNPISVSINSDIIPDKLKIYYIKTSPKHKLSLLKNFLEKKSIIFFTTCAQVDFFYDLFTKMNISGILRIHRKVKQIERNKIYENFHKTGRWLFCTDVASRGIDFKNIYTVIHYDIPVDPLNFFHRSGRTGRNGNTGEVFLFLMENEIKYINYLKIKNIDTEEYECKDTSKHTSNIEIDNEITELATKAVISYLRSYKEHALSYLLNIKDLNQEEIAQAYFLKKIPENIFYTKNKNRFGIYKTAKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I5</accession>
    <name>A0A4Q9M1I5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0192p0020</name>
        <name evidence="1" type="ORF">CWI38_0282p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000282">
        <property type="protein sequence ID" value="TBU17619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000192">
        <property type="protein sequence ID" value="TBU19828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0192p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0282p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="475" mass="55478" checksum="0D7FB4A54E4DBAC3" modified="2019-07-31" version="1">MSDSNRKFSQDPYSLTDENKEIEISKLVKSKNLFEKARKYEKLFTSETKSLKKIMRSLTMSTIKKLQCTKVESNYEKRIVCLSLSGDETVRFSSTLRNRKNDTVTYDDYVISFKVLQRESLSPLLFVLCMDPLSQIPRKKYTKETIQTDAESQTNNPIFLLSDLKLFGFDKIFEGDWLGNQQREDSTNALYCEDTCHQIPLKNTRGNPIPGSFDELDDAVRAKLVKTKLLLRLRCKERLYISIKEREVAYLVYVANLKYASATFRCSKNELRKYKLHEQQSSRLFKSKVQVGEEVKRKSLEEAQLTKLYNKIEKLKLHSKLYNARRNELVGVSDSSRWPKKGNIGPRNEAMFYYCHDRNLIREADERACRDKSEHQNKNDVKIRCNRSQIFISEKIKKMIPLIEVEIEMKKLRKYDLLAAVLVRNDEDSVNHLKKKNNTLYMLEGGTKFVEPTINLNEESDLEEKTGVKDIGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M233</accession>
    <name>A0A4Q9M233_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0028p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M233"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M233"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020891355" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126762" checksum="B3CCAF5FBEE52EC0" modified="2019-07-31" version="1">MKNILLCQNWIIFGCVLTKIFDPIDINSIYKNNNANETNTRISMFDGGGEGESEKNKDEIGKSEHYKARVSLIDNIISKSIEGSKSAFPKSEDDQKKVLTLVELDVRNEEPFDKKKMKFTVSGSEGGKKKAKKTKTIQKTIFIKDYMGNETKEINGVDDEKDFITKNEPSSILISDIPDLESKKAKPIENKEPTKHWTTIYGKDGLEKVLMDVKTITIVESIIEEPAKAQTIDSAKETNRNTEEPFGITSKNILDIKKGIKNENGDSKEVKSKLFSSIYESLTKKASVLESMSILGESIKKTDKKSSTIGKFVHHLSSTETEPYKTSIQISNAISQTGYKTSESSISAEKEDSKVSKSNEKEISRSLNSKSEIASKESISLSKSKEKADESISKSLQEVSKEKSKSKEEEQKSFSKSYKEASKKKSKSEEEASESISKSSKEFKKEKSKSAESVSKEFKQSSKEQSKSLKELKKSTSSKSKEETNLSNSNASVETKKQNGFFDIIKGAEGAQKTSSFTISPSISAQSIQKISKAEKTTFAQTGTISTQNIESISKSMKDASKSISKEQEKSSESISKSMKDASKSISKEQEKSSESISKSMKDASKSISKEQEKSLESTTKSMKDVSKSISKELEKSSESESKSSISVSKSIKDVSKSISKEKEKSVESASKISLSISKSLVEVSKSISKESVKSSESFSKSMVKASKSISKESVKSSESFSKSMIEASKSISKESVKSSESISKSIQTLSKQKSKSLESKQEQKSESAKEKSESIEERKEEKSKYHKEMEKSISKQTISSQEQQSKSSKTVSASIENNKKDTSKSLDKISRSLQKESSKSESKNRTTSSKKTIHAEQPQSASFSTTSPFKVLDVFKMAVNPPTSLTSNNTSFSKGLDVTTSSNILIKNKQLSSNATLAISQTILPTTINSSTQISTKKEDKKENKGLSNTFTSISPTSTSKKDKGKAEKETKKEKDTSFTSISPTITNKSYNTKIEKDKIKDRSNTHTSISQSQGTKTSLLKSKTLESISSLLQRSSILNNIKSIMKGKNVDYDTIEINETSDSSSQESNIPISSIINILKNMPNTPDISSNKNAHEILKKVNEQNNVNKNGPVFVTGRINQGNDTGTDKGDGFKFWGFISSALNNREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M234</accession>
    <name>A0A4Q9M234_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prp31 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0235p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M234"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prp31 C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="29915" checksum="BD0F60972E28A633" modified="2019-07-31" version="1">MCNKLLSLRKQEIEKRSKISLNFPMSLLKRIVKSEENAILNQENNYCNSYSILEMLEYKKFKNIYFEMNFDEKRNVLEIFDKLTEIETEKEELFLANKELLEKNYYNLNNILGPKILFNLLYYVDFKSLVYKTSNEFRNILMKCDVQNHLLFLELDKSKKNQLLRIISNKACIAAKLDYFGSKKIDFLSEIKIIFKEKVEPKKDEKPLPIPIKPPKRQRGGRKFRKIKNKIKKRIEYSTRQLNKDEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M246</accession>
    <name>A0A4Q9M246_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0239p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000239">
        <property type="protein sequence ID" value="TBU18505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M246"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0239p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6084" checksum="50EE6E0F1C049215" modified="2019-07-31" version="1">MVFLKFIGNTKIIYKGYESISVVFKDRENFKANYLAFSGLIHFLFRLNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C0</accession>
    <name>A0A4Q9M2C0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0017p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15887" checksum="BD4C46F470D8BA0A" modified="2019-07-31" version="1" fragment="single">YDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMSVIMRSEVHEEPIPPLKEEKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C9</accession>
    <name>A0A4Q9M2C9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0216p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000216">
        <property type="protein sequence ID" value="TBU19282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0216p0060"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="564" mass="64693" checksum="05E0113F25EF4543" modified="2019-07-31" version="1" fragment="single">MKIIDKTGKFLVEWKISCTLDIDAFKKLAQNEAERKIKQEEKGERRRIATCLAKPCSCADTTLYMNLRDKFLCKIKEISEKEIGKVVVRTRKLPNELLINRIIGEYADSCVPMTITAVARIIQAAQVCYDEATRKEKPRFAWKENIESKISKLVLSKDLLEKALKQGKLYTSETKSLKKVMREFNLNLSSGTDISEALMHESRKKFRKENRMFELFQGRFYRGLSERVEFVHVVSREEIVSFRSTMWNKNDDTLTYDDYWIPFVSDNHPTTFLSFDEFVNIINWLPNWKAARIDGINNFFTKKLTTLHKYIYNIVKVICLEGTPRADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQLEVERRGLLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2F6</accession>
    <name>A0A4Q9M2F6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0216p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000216">
        <property type="protein sequence ID" value="TBU19277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2F6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0216p0010"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="8">
        <location>
            <begin position="508"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="715" mass="83383" checksum="8CADCF7B58158D63" modified="2019-07-31" version="1">MANDSNKEKEPSNKEKNEKSKDEKKSNDTKDKVGDVKNQDKEDKNEEVKEEDVIQDSMEEDSKEGNVENPEAVKEEENLDDVTSAKADNVIEDIMAQEEHNEMEKQEELHKKFKKREILKQKTYSIGNIDEYFHEKYSNINIIFRYAIEMAIVLILFMSWSILLSLICRDPNTYPIFKTLTSDKKINETAEFIRESFFVSLVYIIFVSVTLFIDNLLYIVVYFLTIFGVEVVGIVAELLHILRRSRHHLKNSIVAYLVFVMANFVLANYKFFAQKKDFTYIFLTGIFWFGCLSAILFAESFLMNILTSELRNKSFKGRIWDANYKTFIFKKLAAIAEATPYGKHNVNVIISKMNVDYDTGFYLKHNELDLSEPGAVVESILGYLEVDQLESEDIKRFFPNNSDEVINYLYGSVPESECVSISYEVLKKRAEDLYQERTDIMRSLYDRDNILRKLNLILTTLGFSLSIIIFMILLNLNYKVYLASIGPFIFGFGWIFQDSIKEIYRCFVFLLINHPFDCGDRIILDNEELTVLRIDLLYSTFVNINGRVTYIPNGAMFLKKIDNVRRSDLQAEDIIIRVDISTKYSQIIELKTQVAEYLNKNAKDFTGKIFLKNCEPEETNLKIILSIEHNSNFQDPFPKYVRREGFIENLEKCVIMRSEMHEEPTPPLREEKREEDGEKKNFKPKNKALFISQGGTTLEEPTNNINEESYLEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K3</accession>
    <name>A0A4Q9M2K3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative subunit alpha of transcription initiation factor IIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0004p0110</name>
        <name evidence="5" type="ORF">CWI38_0006p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2K3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0020"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="36310" checksum="47E01378E2D4ECB4" modified="2019-07-31" version="1">MEYEEIMKKLIKKTMRMFYETHHAVIMDILLEYMIMYDNEICEKMKMLNKEFNRLVVKLKDDKLLKAETKIETKSDGRQLLRCVYFIVYSEIKDVIKYKIFKMSRFLEQEIKNTEKLQGYKCSSCFKEFGVLEAQRLLENFIFKCDECSGKLIENKGKTSIDDPHMLHSIMMNELSEVISMLKELDKHNIPSIDYFQVLALRKGKEMMKSSSLKSEYKICEIQEEEEKQEIFVENEEKNVELSFKVFQKQEESKNEVKEESSIFVNVNGVSKSFSQITEEDKEKMNEDEYEKYFEIFLKQNEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M5</accession>
    <name>A0A4Q9M2M5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0101p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000101">
        <property type="protein sequence ID" value="TBU20258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0101p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13363" checksum="703D5DC0C51F224F" modified="2019-07-31" version="1">MLNGYKYFALRDQYHRPGEVTKFTEEESPIEYNLEFNQESNLIPIYCNAIQQATIFSPKRVDTNYRDIYIPRIAKDADVHYNRIAFNSENVVLIRRFFDTNRSPRSDKINSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M300</accession>
    <name>A0A4Q9M300_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0137p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000137">
        <property type="protein sequence ID" value="TBU20072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M300"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0137p0040"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="153"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="51788" checksum="942B146DF6C3847F" modified="2019-07-31" version="1">MGNSQSNHLKKICLGKSNSHTPDILRFYNIDDHLFPYDLQTIEYNPYPKLNFASKMAKVNKIIQNNLNVSPRQSFLDYEKVCGENLFESFESTYRDALRKNCYVKHIVSDKKNIGQQIYLCRRFLIELSDEIQYLENIKIFQVCCNYLETIPSAIGKLHNLQILILARNKINKLPDEIGHLVNLRELNLSQNELSSLPNTIVALKKLETLHLDCNKFFELPETIGRLVSLRYLNISRNYIKYIPIEILQLPNLSELDCSWCDFTEKTPVKTIKKNNFFSLKEICSRRMFISNLPIYKYIDSNLRNHIMSVKECSYCTGPYFESYIEHQTTYTFLSNNYPVKYKLCSLHFKTKSERNYKLFFNASKSFPSNLIADGLPPVSEVFNILCYNKRQILLYRDYLNNQEDYDSLVPLFSLNRFTDIPNWLDYTNESDNNGIFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3J1</accession>
    <name>A0A4Q9M3J1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0023p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13014" checksum="21F701C24555776F" modified="2019-07-31" version="1">MNVEAYIQYIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Z4</accession>
    <name>A0A4Q9M3Z4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0068p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Z4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3Z4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0020"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="270" mass="31483" checksum="76D863FDA45E9DAA" modified="2019-07-31" version="1">MAFAEVIIGPPGGGKTTYILRKKEFLKNRNLYIVNLDPGNEILVGYHYDIRNFDTTKEYMKKYKTGPNLAVKEIINNFTNSFKEIFDEIIKKCEDSYFLFDCPGQVEFFMTDSSLKRFIGILMKQGIGLTVVNLVDSVFFVDKHAVISTYLLTTISMILLEAPHITVISKCDNLKNYKLQLKLSDIIMCRNLKELLNEKDTKALLYKNMIEVIENESLIIFEILDYNNMDTLIYLQQIIDKANGYIFDIDYENYEFCNKIISKEDFLEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M480</accession>
    <name>A0A4Q9M480_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0072p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10127" checksum="19A602080096BA36" modified="2019-07-31" version="1">MSRTIISDVDSIASDSEDGEIGGDTSSDDSIIITHRRKRLRIESESSISSSSSEAEETPTFTNIPPTNVFSKATNNFFETPGPRCAPPPMLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4K2</accession>
    <name>A0A4Q9M4K2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit delta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0060p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4K2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4K2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0010"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="382"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="753" mass="82771" checksum="90E9681F1A19DF13" modified="2019-07-31" version="1" fragment="single">MHTKQSSRTSKILTSNIQAASSLSSYLSTSLGPSSHTKLISTTPPTITNDGATILKSLKFKHPIFPLLTNLSTSQDSNCGDGTTSIVVLTGYILDVLYPLTTDVHPTYISSAIQLAIQYVQHTIHTHSIHISTDPHTTTLLHSRSKIEVDNSKEGSKLDSSKLDSKLDSNKDSYKDNNIRDNIRDNNKDNNKDSNKDSYKDNNIRDNNQYTNNNNNTNNNNNNNNNNNNIRDNNKYTKDNNIRDNNKYTKDNNNNNNNNNNNNPNTTTYFSLGNKILVNAINTSLSSKITPSSILTPIAINSIIKTKGNIKNINIIKKEGGTFEDIKMYDSLILKYKVTRGESIRECIREGGMLECGSNSSKDSSKDSSKDSSKDTSKDSSKSSNNSISNSKDSNKDSSNTNNQYNNQHNNTSTNNTSTHNNQHTTTHNNNNIIRSLAVITFPLSLPKPYTDSKVSITTSNLMDTLIKEEHLYLKNICNKILEKGVNIIIIQKSILKESINDICKFYMERKGCWVVSDVERQDIERICMCLGVEGVSDVEYIEGNVREVEVEVCEGYIRIGGCGGVCGRDGVCGGEGVCGSKGGSSISSSKDIRDNSSISSSKDTRDSTRDSSIEDTNNTPIHSSNTNNTTNNTTTNNNTTTNNNICSILLTGGKDVLEECHRNIIDALSVSKCLYDLPFVVFGGGWIEEVIGEVLIKEGNNIGGSKGLCLVEISKAFKRIVLSIRSSGDIVFMPVKVCMGYICMALECAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JV39</accession>
    <name>A0A4V2JV39_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0458p0020</name>
        <name evidence="3" type="ORF">CWI38_0529p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000458">
        <property type="protein sequence ID" value="TBU02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000529">
        <property type="protein sequence ID" value="TBU13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JV39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0458p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0529p0020"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="350" mass="42120" checksum="192CF2B43EF02940" modified="2019-07-31" version="1">MDEENEIQDLLLCKKNILTEEEALLVFKRICRQLDHKDNLFLDLNQLKLYCYNGYCNKYLRPKYWKLFLGYFPKNKFKYDHFIKSRRKHYKFYYENAIRQKNIKLLCDRIINNDIDRTILFPFTVKENNVEKIHCKFLDSDNSSLNFSSSHRDSIKRILLTYKITNSSIGYVQGMNMILIPIYYVMINSIDEEDRLYAEEDSFFCFYNLMAEIGENFMQDMDFDKENGIRSKMNNVFKLLKLADSHLYNSMEEKGLLNNFFHFRWISLLLSHEFSLDKVILLWDKFLSDYNRFEMVTFCAVSILIDMKDTLICSDFETCMVELQSCNKKNIDLIFKLADKLRNELRNMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWE9</accession>
    <name>A0A4V2JWE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2363p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002363">
        <property type="protein sequence ID" value="TBU07702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2363p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="14277" checksum="E1D3185279C7CDA1" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWZ9</accession>
    <name>A0A4V2JWZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2122p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002122">
        <property type="protein sequence ID" value="TBU09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2122p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020947858" evidence="1">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="322" mass="38178" checksum="BDCB6ADC98FCD473" modified="2019-07-31" version="1" fragment="single">MKIQKMILLSLKMFILFFNLRKSTSDETINFGLLNSYISFEFSDTFMFYLYSRFEETEVFDHEVSGCLTNESKHYSEEMILKSDEPVSFILLLENSSSKHLVKSLGFVAQIQDILKKIQVLEKNNEDKMNQNIENIWLSSTIQKYLNETHKITSKANTRNLSPPSSQSYQISTENLRFIQNRGEETDSDLFFIKYIQQWEFVRNIKLEFFKKLFYNTEIKKILSEYLEFQNTENPNTGPDSFIRLESFLECNFEKIQYLFSQNLNAFFDTTFSTTIYSALESNLYENCFFIGNNIILLNNNHIWTNKQYIYVFDIDSTLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX23</accession>
    <name>A0A4V2JX23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1990p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001990">
        <property type="protein sequence ID" value="TBU10142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1990p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="20584" checksum="032F87C02811B6B4" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEIHSHSIFNHLKKSIGAFNSHKIIKVKVDYDIIEVTVTEKNIVSYINSSLILLGNTGYGKLSIQFLDEKDVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX25</accession>
    <name>A0A4V2JX25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin/thiamine adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2005p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002005">
        <property type="protein sequence ID" value="TBU10122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX25"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2005p0010"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="86"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="19951" checksum="65C24C8321BAA456" modified="2019-07-31" version="1">MCGVIGSLQAVEALKLILDSCKSFLLTYNGYENIFKKVEINQKSERCLVCTEKKIPPSNFGTCKNQIMRVSIDDKYKIKWKDFLASPTQYLLVDIRNKILYDMCHIQNSVNVPADTLDENNEIFKDKRKILFLCKKGISAQKVAAKFLEKGKNVFVVDGGLTKFKSEIDLNFPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX41</accession>
    <name>A0A4V2JX41_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1836p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001836">
        <property type="protein sequence ID" value="TBU10342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX41"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1836p0010"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="26178" checksum="86689BAB2E7CEA01" modified="2019-07-31" version="1">MKILAQGAEAKILLIENIIVKERIPKLYRPVELDNEIRFKRTRQEKKIVDKLYQNSILVPKIVKPLQNFDHKTTLFMEYIEGSILKDFLCQIEKYKDNFNKSEHSDSFSIKITKIKNIMFRLGETIQKMHKLNIIHGDLTTSNFILKKEDLYIIDFGLSYFSTKEEDKAVDLYLFEKAIRCTHPEFIIDYFYEGYTDKIVLNRLIEVRKRGRKRELNSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE8</accession>
    <name>A0A4V2JXE8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1150p0030</name>
        <name evidence="1" type="ORF">CWI38_1540p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001540">
        <property type="protein sequence ID" value="TBU10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001150">
        <property type="protein sequence ID" value="TBU11542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1150p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1540p0010"/>
    <dbReference type="OrthoDB" id="2189928at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21788" checksum="A4C2F7C09E6D9A04" modified="2019-07-31" version="1">MIYFQEDCFKEESLIEICTFPQIQINKLFLEMAKQKKKVFFMDTIGNIDLLIKHQNRNKEYECFRIFSISDFYDVCSILQSETGFYLFIDSITFVIEWNKYSIKPGEENHPKKIYNKLWDLIYSNNATIIVTNHYRPKLENGNKVYVPRLGNCFFRIISYRVLLKNNDNEIEYKVIVNDLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXK6</accession>
    <name>A0A4V2JXK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative U6 snRNA-associated Sm-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_1052p0020</name>
        <name evidence="5" type="ORF">CWI38_0858p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001052">
        <property type="protein sequence ID" value="TBU00295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000858">
        <property type="protein sequence ID" value="TBU12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXK6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1052p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0858p0020"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU00295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="91" mass="10606" checksum="F70B7F4A037443FE" modified="2019-07-31" version="1">MYPLTLIRISKGKNIEVELKNNDIYEGQLIECDLLMNMHLSTVVVKSLSKDPYFLEDCFLKGSVIKFVKLKENAMNKQEILEKRSQKNKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ2</accession>
    <name>A0A4V2JXQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NLI interacting factor-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0285p0060</name>
        <name evidence="4" type="ORF">CWI38_0648p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000285">
        <property type="protein sequence ID" value="TBU03499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000648">
        <property type="protein sequence ID" value="TBU12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0285p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0648p0010"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="306" mass="37034" checksum="D584BFB8E2B18A3C" modified="2019-07-31" version="1">MFVKNVFLKLKNDYKKQKFPYFSTFLLASGVGVYFLGKPKEGESKRIIDYVKRSINKSKRFLWIEREIPTLPNQIEKKPVILFDIDNFLSKTIFSFYSFDYILKKRQFNDVFLFHLAHMYELVAISQSNKYIGDAFIRQIDPYGCFAYKIFLEDKTKFCLKNLNRPLENTVFISTKNNEFNKEFEKNILYLNPWNGKEDKKLLSLLDFFTNLFFVSSKDWRNTLFSYQNKDFFNEYSKIQRKLFDQKHFFRLQTDDLFQNKIKQINDERIGDFYKAKIFMDQKIQMENQKSGFLSKFNWLVKKIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU6</accession>
    <name>A0A4V2JXU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetylglucosaminyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0511p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000511">
        <property type="protein sequence ID" value="TBU13172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0511p0010"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="374" mass="45227" checksum="833CADCDCA63BF20" modified="2019-07-31" version="1">MKLTKIFLLNIKPKFANKFIYDESEAIFLTNNSFCRNLNVLTFPIVYTEKKTFFFDFILHFENSKIHVEHKGNKLFNLYFIHHRKEFEKLDTLCDYSLNLRIAKQLIKVTNDYENNDIVYGKIEKNFVNHNIFKSGLYILIHFIIFQKFILYLNLLNNSTIDILSNYILLEPFRLKMNQHIQNIIFHTVYKFFRIFNFYISTYFVNNSRISLINIFSCGLIFSPEKIINLICFPLEICNNIFSYIFSCIVRVISDLFVLLSSKNYNRIQKRYDKIQYSNETIILATILFVIFLILFYNLFPIYLLFMVVNILRRSILFAYDLIYLILSNDTYNTYYKIKREDEISYLYLFESNLLFKKVRNMVSFVKYKIKNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXX3</accession>
    <name>A0A4V2JXX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0435p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000435">
        <property type="protein sequence ID" value="TBU13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0435p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="8864" checksum="998CD3452411AD67" modified="2019-07-31" version="1" fragment="single">MLAEKNKNINKLKAANDADEVNKSESNIQKCELHPPANSQPSFSYTTTTHPPPNKTCSSIQNSGLDTLKSPNTPLPNSVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ0</accession>
    <name>A0A4V2JXZ0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0366p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000366">
        <property type="protein sequence ID" value="TBU13672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0366p0030"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12398" checksum="DFC8BBAE10DE9C6A" modified="2019-07-31" version="1" fragment="single">MKVKKLLISLIAMIFVLVIWIIFIISSKRKDIEKVSAEKNRTKVSEDTLLLSERNFVGLENDKYVCYFNSIIQALYVQTDFMNKIFSYKHNQNQKCIILLKEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ6</accession>
    <name>A0A4V2JXZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0355p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000355">
        <property type="protein sequence ID" value="TBU13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0355p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020254960" evidence="2">
        <location>
            <begin position="16"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="550" mass="66111" checksum="8A47287EE4E7BCFF" modified="2019-07-31" version="1">MILYIQLFFVSFGFSYDAILVDPFAVEEDFVSIPYNAENNESIRNILKKFDVKDSPNYFDKLIPIIEIYTKNIYLYFNKDMYEFIMHYVCIICYIKYYYESKRSEQKTKKIELNIELLFNLISTFKLYWLCKTEKKFNEGLVYVEGGLIDKVINMRIYPGYEDLMSIDKMKQDYPLVFNRTTKLENFEFILQESNLEHCSFKFSSSELKDKNLQYYISKSSFERLFTFIFAIKYFYIFYKNLDTIDIPDYTILLNKKFSGFVNDISLWFPQLLMSYLELDDYKHLYRSIFEETLKSVSRESNSIDKIFELEKSRNQYMNYTKDYSFPKYLFDLFMSENDLQSIISIYNFLKEILKKEYYSFISTVLLLKSSCLIEKNMIQERFLRVIFEIIFFVDIIEKNYSENDFERKITSEILEINARIENLLKKNKKEFILDDRGNFFVQNEVLKVSLSLKIMLQSIFYLSNSKKKLLYSKVEEKLKNRKISYNTSEIFRTYFLFLVAQELNLKIPDDENRSASKKEKSNIKKILTFGVVVTLLVIIVISVHFLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC4</accession>
    <name>A0A4V2JYC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0049p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="674" mass="81188" checksum="E3491DDC069E9CA8" modified="2019-07-31" version="1">MCIKSKNIEILEYIGLNQSNVVQSLEFMSKILSILDKFSTEEITIFMATYEYKDTKIKYKNEEIMSLSEIFRKIPTLKNFTSSETFYEFDINILNDTSKLMTISIDSIEYLSFLRAKIKDRNVEMLCKKYIYSQNIINTTVAIFSIILQINKPLKIYNLEYNKILELICKKCIFDFCMNQPEFRKGIVLFFVKNNLFDISIFKVLKDEFIPFNWFKNVETSNSEGKELQYNDLYSLNYKSKINITKDLDENGIENQDTYFLNSQSKIINNEFIEENDHKTGDLYPLNYKSNIIHKENLNEKNHKSEDLYFLYLKSKIIIKEDINEVIKNKIFSDNILLLIFGKKVDFNLFNSEEYLKYALRWEESEIFEYIFEKYLIFYVKYEIKPKREIYRKKYEIFNEIYKFLNQEIENPPILHKLNYFSLEERNKLLEKYIKLYNINEIIETFFDVEIYSNVLKEYLKLNVYKIAKPINFCIIISRIAYSDVNEDLLMEKITSLTKKEMNKFFTLKISLLPFKKWIFSQETLPKRYIEDFFEEIVDKLDFLESELLKSLNFVSNNFLINIFTVFFKSSFCKSVQASIIIKFLEEINLLKNPHKKFTNFVIESQKYYLNEILTDDFFQKEDIISCKKFLDNIFIYLNFTHNLEISTFYDEILIKLKWWCSYHNEVVTIKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE0</accession>
    <name>A0A4V2JYE0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0031p0090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0090"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="45"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="568" mass="65252" checksum="975A94CADD5B7C37" modified="2019-07-31" version="1">MKVNEVSDISGNIESELNSILDEKAVSPGYIDESQYLLQKIVGKYKLTKNLGSGGTSKVKLGINNETGEKVAIKIVSKKMSTSSLGKDTEAKRDERIYREVLISTLLNHPHIVRLKDFYYNENNFFLVFEYIKGKQLLDLVARNGALSENDSRRFFRQILSAVGYIHNNSIVHRDLKIENILIDDDGNAKILDFGLSNFYDNKRLLNTFCGSLYFAAPELLMGRQYSGPEIDIWSLGIILYVMLCGKVPFDDKDVHALHSKIKKASLTFVKSLSSEAEELLSGMILATPSSRLGMDQIVKSVWVNKDYKTNVDFFNNRKFLLKRLRTGYLKLISYVVRSQFPDMEKDVRRYISICKEGKSESLEQIYWARRPTISLYYLFIEAVGLNEDLIEITEDKIDESDISDELCLGTEEDRPQMYHNFVSFVFSKEKNNSFSKYFTGSIFLNSESSLNHIEKTVLGDTSNIDNLPAIKNTYLKGFFKGIKIKPTLSHTEIKKILIQFFTAMKITYEIKEKNYKLIYDINETKCEFKISLYFNKLFKEHFLSVTRLSGDKKLFRDALVSLAGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE7</accession>
    <name>A0A4V2JYE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0022p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0030"/>
    <dbReference type="OrthoDB" id="2193238at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="347" mass="41471" checksum="18D33153343A084C" modified="2019-07-31" version="1">MSKRIKAIENSLTDSENTKNIIKKQENAEIEIEYLKKENIKLRGEISIVRQNMVYIERENYSMKEQQRQKLKENLDKADVLKKEVKMLQMANKIKENQLRAFKVPSAGIQELPTEIDNKWILEQLYPKIFNSEPKEFCEKYSEINFSSISGDFADCDYNHLKFLQDFLPKELNNIISHPNLFVFLENMKDDFEKFLSHFLIFSIKKDVFDKYFPFILEKKIYNNSDHTDKIFKIINYSPFEWIMELLNTDNFIGLLAHFLKINISNDYTLLFYIKIATERSFILNLFLTKDMFDILVKNTNNYYIKKLIQIICTNKLISYVDSNNINYIGIENLKNMFGDEFFEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG2</accession>
    <name>A0A4V2JYG2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0009p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0030"/>
    <dbReference type="OrthoDB" id="2191229at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="34588" checksum="03699FEAE268302E" modified="2019-07-31" version="1">MTDQDITYSTIEHDYMQLKDTFDNHKFAYIEKLTKQYFIEGLCSKDYEKNNIISMVSSSKIQLREVKGLVEEQEELIKSISIEIYELEKKNKEYEIELNELLIKEEEYEKRYLEFNEKLGNVKIMDELCNKVKQKNDEITETMEIIENKNENLKKMDVTKLETDLYDLQIRKEELCEQERNLSRIFYDDSLVEMYEWYLNGLQFLNKLFFCRIEEIKIKENNLTEIYFGIENLSVVACIEDRKFIGAKAFYLERNQDLFDSLVNECVFINDLRLFMCKLPFIISKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN8</accession>
    <name>A0A4V6MVN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subunit Sec6 of exocyst complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0311p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000311">
        <property type="protein sequence ID" value="TBU15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN8"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0311p0040"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="83482" checksum="7C2920D2F486C46C" modified="2019-07-31" version="1">MHETLENVNDTLKYPSDLEDKLPSILSAYEKHVNEQEEYLKTKIRNSRDRINNSINLQQKIKSDIEIYKSNFEKLDQIYQSFPKVVNNYENIKIIAIAHQNFHKSYEMHKKLVNISNATENILKMIKNEENVENIHEEVFELEKFKYEIHFFSKNITRDEFLKLNEIINQIDRVLLEFENMFLLKTNNLINQLEINKEYLNQISKIVKKEEERDEITIKVQKGKHSHDAILHEIYLLNKIYFDREIKDIKNKTIKAIKYSINDKFPKLQNKDFNIQELNFIIEDMKFISETVNDKDLFIDLRFIYEEYHLQLKNFLDLNKNNLDASQILFLLEFINNYNENIEKNLNMQPETLGESLLGDSESELINKYLQIASEKLVSWISNITVIEVEKFNLRTSQPTVDENDKYISTGFINLLQIIKQQMEPITFNKHIFLQITSIVVENCHYFKNEIIKAMKKDFKPSVTLKSVPGYEEYVIMIGNSGLKLTQYINSLPLCQKPEVRELGNIFLEILKSSNTLLSEFIITTCGPILDKVFTDSWYEQDITKKLIITLEDFLGDYKITMADYSFITFVFEICNSLVFCYVKQITRKRAKILEDCSDKLKSDEKRLIQTFCKFADPQEVKNSFMPFDKIIPLLTTKNDDLFVVELKSLILVYPDIKKEFIKSIIKKRTDLNDSDKKNLIERLKESFGEEPKHNKKTLFSRLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTV7</accession>
    <name>A0A4Q9KTV7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1965p0020</name>
        <name evidence="4" type="ORF">CWI38_0032p0050</name>
        <name evidence="3" type="ORF">CWI38_0048p0020</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001965">
        <property type="protein sequence ID" value="TBT97984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1965p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15143" checksum="A87A39F6A5523664" modified="2019-07-31" version="1">MNLNNILENIQGIFNKYRITLNEEICGIKKLSDDTNPKVEETDILERGSLKKIQAVKEYILSNLNLIGAEDGVKSYGFTCRNYQGDEVESFTSASTPSALSSESIISDLTKSFDQKNSDNKPPLPPKKRNSIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYH8</accession>
    <name>A0A4Q9KYH8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1249p0010</name>
        <name evidence="6" type="ORF">CWI38_0353p0030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001249">
        <property type="protein sequence ID" value="TBT99694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000353">
        <property type="protein sequence ID" value="TBU13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1249p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0353p0030"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT99694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="208" mass="24138" checksum="CB39066095CE9074" modified="2019-07-31" version="1">MEKTTIYQKEKEILQQIESLESSYNEMSPLYKFKYIFYNIVSQPIETCPIDFPVHLWERAIKNAPALNTVPVVVKGYNGLEERRKRQIDVTTKIKESLESLCLRTGKLKMRTENITCRLKNAGDSYKKLFSKIYCNIRQNNTTGLTGELFRLKGYINEIGIRNANSINKDYKEQVINTLGSFKNLGVKMLQDLENDLKVLESKKNNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2Q8</accession>
    <name>A0A4Q9L2Q8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0904p0020</name>
        <name evidence="7" type="ORF">CWI38_0387p0030</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000904">
        <property type="protein sequence ID" value="TBU00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000387">
        <property type="protein sequence ID" value="TBU13582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2Q8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L2Q8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0904p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0387p0030"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="194" mass="22404" checksum="C4ACFB69FFBE6FFA" modified="2019-07-31" version="1">MESQEIKSVKIPFYKHNLIKKEWFKIYTPIVNHCYLQLRMNLATHSIDLRATPHTKDLSVLTRVEQYINSIIIGFNPEDIVDMLSDSNIYYDSFNFSEVKTLKNEHLPRAIGRVVGREGKTKKAIELATKTKILVMDSNVHIIGRSEGIEIAKDSICRLIMGSQPGKIYNRLRIISSKLKDKHFGFEIIKNDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDA9</accession>
    <name>A0A4Q9LDA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit Rpn10 of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0092p0020</name>
        <name evidence="5" type="ORF">CWI38_1882p0010</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000092">
        <property type="protein sequence ID" value="TBU04750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001882">
        <property type="protein sequence ID" value="TBU10278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDA9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0092p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1882p0010"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="210" mass="23859" checksum="99FB7AD1A85D6882" modified="2019-07-31" version="1">MPIAVMVVIDNSMYMQNQDYLPSRFMTQKECLNTYISTTLNDSVDSAVGIIPTCQYVPNIMITPTNERFNLNQFLHKLPLHEDFDISKSFKLAYLALNYRQLEEKSILVFLGTEIPTKLEDEMVKSFIDSICVALELGITVSVVFFADGIKYSEWVNEEIESNGFKSVVVKEKESFYDAVCSLTGCKSEEFEDDPELALAIKLSLEEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE28</accession>
    <name>A0A4Q9LE28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2619p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002619">
        <property type="protein sequence ID" value="TBU06207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2619p0010"/>
    <dbReference type="OrthoDB" id="2196200at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="596" mass="71957" checksum="39886E9BC588EFAA" modified="2019-07-31" version="1" fragment="single">NFYAIIQSKEILIFNYPIKFIKKYIFKQKLLKVNVSKNEIIFVFESYVILYKSDNIVDDNEYYIEDGYIFYRSICIYNLRDTIEKYIGVKFGLDGMNNKLYYFFNNLMHEVELCRIDIENLCIYYDRYVEIEGRKIGCRISKNGILKIFNENVAISDTYCIKINAIEKNINFLVENFYFFKENLLFINEKFISIRNMKLIEVKRMEYLFFKMFENEYIIIFSDQPQIHKELEMKEDKTSCNLDIESDQHIENIQSIQSSNEIDLATHYSQTRIFSLFYFVDTKFISTLRIFDYKKIIFCKKANQNIYIFLNINNFLEIRIFSIKEQKIINSKLFNEKLHNPILNINDLEIFNQNIEVTDILHISARFLNTDLLISVTTKKYLFFIFKEFLIRKSNIKKAFKTDLKLLKYFYFGSKTLESSCLCGFLIFFIFYLDIEILQILDIFKCKYENIIYELINLSNINEEYFLQIIKIILKFSYKYENLITCIYRRCDKKENLLNLISFEYFKNIKSPESLRNIIVFFPDLLEKYIELCIFNEKEFLIPEIIDYLDKNGDIKGKNCIEKVFLKYNCLYLLKMCKPEIIEDLKEMNVILKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF28</accession>
    <name>A0A4Q9LF28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2644p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002644">
        <property type="protein sequence ID" value="TBU06095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF28"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LF28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2644p0010"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17557" checksum="F2E1E9F76B399443" modified="2019-07-31" version="1" fragment="single">MMNLYNHLKKMEKLMDNAALKRKLMIEDSHCSRLKCIKTLRIFISISLNPFLLKIEGRVINDYKNNVTVKTSALLKRIYVEFNNTEQKSEDIAEVMVYDNKDILCPPISEIPIDHIKEDIIDSFEWIRSDKHIDGFELKTDKTPNSIQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFK2</accession>
    <name>A0A4Q9LFK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2504p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002504">
        <property type="protein sequence ID" value="TBU06803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2504p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="9237" checksum="7E85FFF0AF1CC518" modified="2019-07-31" version="1">MANILKKPWKDRKIKKPSNPINWEKRKQIRTEEKQEAQKMRDRVKQIKDKKRKYFEEKRLREEQKKASCSDNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG18</accession>
    <name>A0A4Q9LG18_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12 16">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5 12 16">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_2486p0010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 16">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12 16">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 16">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5 12 16"/>
    <dbReference type="EMBL" id="PITK01002486">
        <property type="protein sequence ID" value="TBU06914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG18"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LG18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2486p0010"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000032">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7 12 16" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 12 16" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="17">
        <location>
            <begin position="178"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="30"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU06914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="461" mass="52414" checksum="B24A43DC28D06211" modified="2019-07-31" version="1">MDVGLIGLGVMGKNLVLNIADHGYSVAVYNRTYNKTIEFITETNKNTIKGYEKLEDFIFSLKEPKIIFIMVMAGTAIDKILEEISGFLDINAVVIDGGNSHYLDTERRCYKYFGRFNYIGCGISGGEEGARYGPSLMPGGNKEGWVLIKELLCGISAKFKIGENEFPCCEWMGEGGSGHFVKMVHNGIEYGDMAILSELYLIMKYLGMENEKMADTFKSWNDEHQFSGYLLNVMELVLKKKEKQEYIINSIEDKSEQKGTGRWCVVASIENTTPSTLMAESVYSRFLSNQKDLRIDFSKKIDDCLEITNDINLNEDDLKRTFFMAKAVSYVQGFNLLRNGSKNNNWDLNLPSITRIWRNGCIIRSNFLEVIENIVQEVDENFELSDIFINICKQNIQNLRKVVGFSICKGIPVPVLSACLEFFDILNTKRGGGNIIQALRDYFGSHMVRFLGKDEDEHVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIQ7</accession>
    <name>A0A4Q9LIQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MRG-like chromatin modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2488p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002488">
        <property type="protein sequence ID" value="TBU06900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIQ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2488p0010"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="6">
        <location>
            <begin position="95"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU06900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="28893" checksum="FE09118014D5C7EE" modified="2019-07-31" version="1" fragment="single">MKVKQQVETQQKKIYINNYIITKSRDEWIEGRIIKIIEVPKPSEEKPDMNIKKYIIYSLRHNIICEEEIPEHSIHRSSIENYKKFKLFPLRAYVEDIHIPVDLFEILKNDYKSVKDKKMIVLPSKFPISKILKEFSKFIVANKPSISEDEILEVVKGFTWYFDKLINPFILYECEIEQYIQYFEKEKNVNLPSNCYGPEHLLRMIFAIQKFLVKDCMDYETQDVIFEYSVYLCDFLNIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL61</accession>
    <name>A0A4Q9LL61_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2199p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002199">
        <property type="protein sequence ID" value="TBU08974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2199p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22224" checksum="E821838A96BA4280" modified="2019-07-31" version="1">MTEKKNDNEIKNNIFEKKPEEILTEYKQKESIFVSNESEVQKKEPSAFLESTVNKPSPKNVDTSGFDEIPDCIFQKESRLYKFINNVWSDIGRGHMIITETENKKRILFVREGLKLTFLNFYITYDLKADLKENSVSFIVYEAIENTDEKSETNYSCSIYAIKFKENSSASEFYNLIKFQEEILEKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN69</accession>
    <name>A0A4Q9LN69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2102p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002102">
        <property type="protein sequence ID" value="TBU09863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2102p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="398" mass="48367" checksum="BEBC3ECD8E3B1907" modified="2019-07-31" version="1">MVVCLFERILSRHYNIDEYRDIFVKKSLDLYYKKTKELASWLRAVDYTFLFCYDSQIRAFANVLSNHIQAKSSNNYEININIPNSKSTRNIERIKKCYIFACKNKFKIILDKIFRIHKCIGVITCRFNNLNNHFVSIEDTCKGIFKKTPKKYLSYYIDILLNSKNGVWIKVFSEFENFEENIDKDKMIEIFKTTQREMLCFSHLNCTLYIIDKSDLALDESTYRKKFLKKSIKNRYKISFHSTLPNIKNETTVFLLRQTFKFETYFFVTEFEYLYSTKKSDDSEYKFKILLKFSSFTFEFHFNWYVTKHPFNRFRPDSLYYIYVIAGKFPIYLKFHLIQNEIYFRIEKSITIVPSSNCDYIRNLQNPDRDFTLQQLFYYFIIWYLKDKDSVEFNIFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN88</accession>
    <name>A0A4Q9LN88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2104p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002104">
        <property type="protein sequence ID" value="TBU09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2104p0010"/>
    <dbReference type="OrthoDB" id="2188827at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22554" checksum="94B5AA9DBD99BC85" modified="2019-07-31" version="1" fragment="single">CCIEDANNKNLPGKDFKGLLYITCHFDNKKDLERCILLKEKSRVYFTMNNVSYKYEPDSDMVTTVEKLIRQASDKISFKYNLYYPKYKDPKESYPHIDEKTSSGDQLYSDMKYDSKSGQEKETEQDMYKDSNAYVDFFDKILKDGCLKLTIKDKTGLSRVCPPHKKILDSKYYDIDSYNEEKICHNLYMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP06</accession>
    <name>A0A4Q9LP06_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_1657p0010</name>
        <name evidence="18" type="ORF">CWI38_1959p0020</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001959">
        <property type="protein sequence ID" value="TBU10183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001657">
        <property type="protein sequence ID" value="TBU10597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP06"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1657p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1959p0020"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU10183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU10597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38901" checksum="ED38D9FF46A6BB44" modified="2019-07-31" version="1">MKTLILYGILHFLLLSFFTYREFKCTKSFYGTLLATTNNNGLHLLHILFLIFIIYFSTKILLSFTLGSLRSEEITALNDNTFLFLTDTLLILTVFTEDLNIKNLLIFTLLLSLKCLTWIFYERISHQRGLKVFILGLSIILFSSLFFIGSFLSALNHPSMHILFSFEFGIVLITGIRNVSNLIIEEKYQDDKKTVYLFYSDIIYTAFKLISYILFFIFTSLFFRIPFNIFRESISTLRALNSKINNFNNYKRISKELDRCEDVFTDSACPICREDIEKGKIVPCGHIFHASCLKRWVERQQVCPICRQNLFQNEVIFSTENEIMTGIPVVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP50</accession>
    <name>A0A4Q9LP50_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1925p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001925">
        <property type="protein sequence ID" value="TBU10233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP50"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1925p0010"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="479" mass="55265" checksum="A022C4AE6EB52FDC" modified="2019-07-31" version="1">MTQVLQDTLKDKNKEKIENFLLNLYNLPKYEKQKEFIDKEFINTKNIKNIKNMKDLDNVDDTKNIKNMKDLDNVDDIKESINIKDLDKCYVIDMLRSVICMWSDIENNRKDKFYYLICKIIECLVSGEGDKGRVEGVSNSIGRLEGVSKSIGKLEGVSNCIGRLEGVSNIIGRLEGVSNSTNKQQGASNSTNKQQGVINSTNKQQGTSNSTNEQDPVNNNLIEQHPVNNNLIQQHPFNHIDPHIPDYSVMTRQDIIFKLFLEIKELEIKNFILRVLIEKKVLNKEDKDLLIEYISKCKDISTLNVILERCNMLFGDNKEYYRDVICRIAMIRGVSKRVRGVLFSIVDGLKERNGVLCKIFVDLKLKGNIGPPKGMCQHCGKSSKTVYHLETRCEKMPDHDNIRRYNEVVRYPHLLLNRYKFKSSKHIRSHSHTEIRLDIKIKTDAYIQSIVLKKTDEANTRRTNKTLVETSKVEDGVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPB8</accession>
    <name>A0A4Q9LPB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">subunit RPB3 of DNA-directed RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0552p0020</name>
        <name evidence="7" type="ORF">CWI38_0463p0020</name>
        <name evidence="6" type="ORF">CWI38_1856p0010</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000552">
        <property type="protein sequence ID" value="TBU02118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001856">
        <property type="protein sequence ID" value="TBU10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000463">
        <property type="protein sequence ID" value="TBU13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPB8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0552p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0463p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1856p0010"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU02118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="242" mass="27326" checksum="19A7CC2B41FC8237" modified="2019-07-31" version="1">MKVEVISSNDESIKFILKNSSISFANSLRRVLLSEVPTIAIDLVEIEKNNTVLPDEVIAHRLGLIPIYSTNTDLKFHNECTCDSHCSECSISIDLSVSNTDDAIRLVTSNDLFTSSDTPLFKFSKPPLLAKLSKNQTLKLKCIARKGIAKDHSKWCPVSVVSYEYDKTNKRRDTDLWYEEDIEKEWEGLKQDEPDIGLDITEIEMGVEVIEGVYEPVSVVRAGLDVLKNKVSNLIYLLENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPZ9</accession>
    <name>A0A4Q9LPZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1667p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001667">
        <property type="protein sequence ID" value="TBU10583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPZ9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1667p0010"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="19701" checksum="2F0301EF49B575BC" modified="2019-07-31" version="1">MFCVNQSDLCPDNEENSFRKFKFVIDSVKGKDAISTFNGMEITSDKHKGIIRKWHTLIEGYLDIKTKDNFYLRVFMIAVTKRRSDSLKKTSYAHSSQVRQIRKIMFEVIKEEIEDCDISKIIKKLMNEKIGKEVEKRSGVIIPIQNCHVRKVKVIKRIKSAEEEIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ53</accession>
    <name>A0A4Q9LQ53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1656p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001656">
        <property type="protein sequence ID" value="TBU10599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1656p0010"/>
    <dbReference type="OrthoDB" id="2195759at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="19973" checksum="5C7922904237DF95" modified="2019-07-31" version="1" fragment="single">MSSTPSKTLSHDCFIKIVQKLCNKEYEEAINYILTLQKEYNDGLLEILHAYILTELERYTEAREIPITVPTTKGYYYYITSVFKNLNKTVEFKNYVKIFGKSEEDLYEACILNGDFKGSDEIGIKMLRKSKTFMIFSCLCHIIILKENKQEKMLELLLKDEKVSLEVLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQZ0</accession>
    <name>A0A4Q9LQZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit 11 of integrator complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1470p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001470">
        <property type="protein sequence ID" value="TBU10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQZ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1470p0020"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9360" checksum="48E625B714F1F804" modified="2019-07-31" version="1" fragment="single">MQIIPLGAGQDVGRSCIIVYIEDKTIMFDCGMHMGYSDARRFPDFSYLSSTNSFDKAIDCLIISHFHLDHCGALPYFTEVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQZ7</accession>
    <name>A0A4Q9LQZ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1620p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001620">
        <property type="protein sequence ID" value="TBU10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQZ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1620p0010"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="138"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="593" mass="69374" checksum="D5CDE4C24FD35B6E" modified="2019-07-31" version="1">MEFEQEKVERLLKKNFFISPSAHIYGGVSGLYDYGPYGCPLKNNFINFWRKFFIIEEMMYELDTTILTPYEVLKASGHVDKFCDLLVFDKVTGEFYRADHLLKQEFSKMEETDQIKRIIDNLDCLNIKECDEIIKAYEIKSPNNNELGNTTYFNLMFSTFIGPKTQNMAFLRPETAQGQFINFKKLYELNNSKLPFASASIGKVFRNEISPRSGLLRVREFEQAEIEYFVHPKEKDHPKFQAISDLKINLHFSKENEIQKTEKMSIGDAVKNKIINNQSLGYFIGRTKIFLEKIGINEEYLRFRQHKKDEMAHYACDCWDAEIYCSYGWIECVGIADRSCYDLTQHQIASKTNLNAHIQYSEPKCVEFWKPEIDKKAIASILKEKTGDFLKELNNLPEEFISKNLKNNILTFQNIEIKFIRNKKNIYVEEFVPGVIEPSFGIGRIIYCLCEHSFYTRKEDEERGVMKFVPRMAPLKVVITLLKQTPSLQLLLTNLKEEMSKNDISFSINTRNVSIGRKYASNDEIGVPFFITIDLQSMSDKKATIRERDTMEQIRVPLEKIPILIQQLCNNNVKWENLKNEYGLFVFKEEQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD5</accession>
    <name>A0A4Q9LRD5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_2754p0010</name>
        <name evidence="6" type="ORF">CWI38_1683p0010</name>
        <name evidence="5" type="ORF">CWI38_1954p0010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002754">
        <property type="protein sequence ID" value="TBT96765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001954">
        <property type="protein sequence ID" value="TBU10191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001683">
        <property type="protein sequence ID" value="TBU10556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2754p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1683p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1954p0010"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT96765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="158" mass="19197" checksum="704E93B8E38E9BBB" modified="2019-07-31" version="1">MTDNKATSGQIFDYVSEKHPDLFNNENSTTWKGNIRQLLSKSTEFVKLKKDQHTKLHYWTYIPISEQHMLENIPNKVRKKQPAYINNIPMYQMPIFYNNYNPNDPSHMIPQNTYQYNYPTYPINYTIDELYQRNYYPFYEDSILNRFNENENNEENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG4</accession>
    <name>A0A4Q9LRG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rcd1-like cell differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2017p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002017">
        <property type="protein sequence ID" value="TBU10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2017p0010"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15687" checksum="2C1074C6D37D9417" modified="2019-07-31" version="1" fragment="single">DSEVAVNYLKNTELIPLTLRIMDIGSEVSKVVATHIFLKIINNKEGLEYACQTFERFVAISVILNSMVYQCISIPSIRLLKGVLECYIRLTFKGNVKVSLFSKKPEALMHTEIQKQIDSNPECKELFNRFMDIIASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW0</accession>
    <name>A0A4Q9LRW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1302p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001302">
        <property type="protein sequence ID" value="TBU11249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1302p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="76" mass="8871" checksum="A19D48B5BB4F2242" modified="2019-07-31" version="1">MMISISRKIIYRVLTLNNHDQEYTQWDLENVTGIYNMVNASRYLTSTSRITASNIDKNIENDTEVCDILKNIKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW3</accession>
    <name>A0A4Q9LRW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative SET domain-containing methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1527p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001527">
        <property type="protein sequence ID" value="TBU10826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1527p0010"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="426"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="66264" checksum="3EA977A962C830B9" modified="2019-07-31" version="1">MDPEKAVKNIISDAENEYKDEICKILNDNQKYLNLFRKNIPSSSIQPQSYRTNVIPFIQPHPRYTFYMDAPKNIPSQDDPILRYIPYINTTSHENSVNIINYDETSLKENPLNYKEELRERALIKTFSHYSDLDLFNLKNLYDQKDPTVDVHLKNRFPLILAVIKTMDLSLECILNHWEKYFDTRPKTLYNDNNAFREHFCHVCMIFDCGLHEKIANIVVKGNTHINQKIICNCSKKSIKSECQNPKKNQITDKSCLSQKNKKIKSNSSVDHTAIARVLNNASKIIPLTSCLSSLFIKFAFQWDVECNILQNINYVALSAEKFNVPIKKRPKFCTNKIVKFAHDEFFSPCVHKGSCYKNEECKCYKLNMFCEESCLCLECDNIFEGCKCKKCNNKCQCYIYYRDCTPKCGNRYRKPETFKHTCFNTDLSFYNSKTCFIGRSFVEGFGLFAGCFIKCDSFVGEYIGEVITSEEAERRGEFYEIRKSSYLFDLCHKNGDVYHTIDASKIGNACRFINHSKNPNLRAKMFQVMGVKRIGFFAIRDIREGDELFFDYNYNQEQKKNYDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS00</accession>
    <name>A0A4Q9LS00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5088 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1854p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001854">
        <property type="protein sequence ID" value="TBU10315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1854p0010"/>
    <dbReference type="OrthoDB" id="2193826at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031540">
        <property type="entry name" value="DUF5088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17008">
        <property type="entry name" value="DUF5088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="656" mass="76885" checksum="64ACA1B5BCDBCA67" modified="2019-07-31" version="1">MYKILSITRTPPPNICFRIKLYDLSNRIIIYKKICKSLNNEIIKGRYYIGDIIKIISDSNNVIKFEKEFIDLENNILLESNENEKYSDSNLNESNSQESNDLIYKHIDVFATFLFLNDIKPFETRKLKNIELFNLGPELFKCKYGDVYTVDRAIKLKKKSVNLIGKVLYKTRINNNFFVLIFSSSDCLLKIFCWNLKFSSIKVNDVIVIIKYKNCENQGFHSNKIVYNEFNELNYFNCSEIKTVKDTKIYLAQDVEQKNDFDKFSNLYKYKFKPVDSFLEIHSKLPFYSLKGIVTYLSILLRKRNKYGCYLERGGKIYEYFLMRICDTTKSNGMVYSVVVFICSTVFYDVKVGDEIVLINTRKIERGNEFIYCSSIYTDMEIINSVNLNNSEIKNIGKNNSEIEKNTENQMNDFKDVFDENESVLPDLVETLKNDFSKNVAFYENEISDSNIFSDVDSKNDLQNELLIYGAIGFLPDNYISMSDMNVVKYENINGNDYEVGDFFKPYVCEINEIYLICKNLIINESRKVCFKGKLVSFDLKNIYEFDENETEYNSFISENNTLSFIKEDGNISLQTMDVFDIEYSENGMNQIQNSGFAIIENNEQRIRILIFKNCFCESNFVLNNFINLEAFWVVECMRVEEDNVMVYLTGIIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS38</accession>
    <name>A0A4Q9LS38_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1242p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001242">
        <property type="protein sequence ID" value="TBU11373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS38"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1242p0010"/>
    <dbReference type="OrthoDB" id="2195662at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="45744" checksum="D7DEEF422668A0D6" modified="2019-07-31" version="1">MTALNNSNNEKVIIFKRTKRALYYEKKRSGRTIISVASTRIAADLLHKGRTYHSRFKVPLILNETSVCGVKPNSSEGREIHDSSLITWDEATLAPAFALQSKDRLLKDIQCKSRLSFDGKVIKLGRDYRQCMPVIPGAQASDFVHASIKYCSLWNDFKILKLRSNIRAKDKRYSEWLIKLGNRQLINTDGLEKTLIEISSHMISKDIVKDIFGEVLFVNTVCKFSKKVILKHTNEAVNKINQSVLDILQGEEKTYLSTDSLISDDTGDVTDYSFELIVCEMKPNLIVAKLLTDLGKEDYIFLSRIDLTSDAGLPFQLKRRQLPIRLAFAMTINKAQGKKLDKVGIFLPTPAFGDGQLYVAFPRVRSSNDVKVYIKDTAEQGKILLVSDKIFTKNVVFTSAIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS45</accession>
    <name>A0A4Q9LS45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1393p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001393">
        <property type="protein sequence ID" value="TBU11087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1393p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18919" checksum="62E1B7A447F26276" modified="2019-07-31" version="1">MRYYSAIPRIECILQRRWYFSTFHNVWLKLDCLATRFEKKVNNYTRRHNEVYAEIRSETRIKTNNYNVEMIPYMKTRDGIVKKYHKMYLIRCKTLINLEAHIQFIKSPLIDEENLVSLGFIEEDEMHEQPSPSSKQVENKEDSSATQIEKIYYSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE9</accession>
    <name>A0A4Q9LSE9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1414p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001414">
        <property type="protein sequence ID" value="TBU11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1414p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="76"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42870" checksum="B081956501B16D7C" modified="2019-07-31" version="1">MESDPRKQRIITIIVIILLILYIYGFGVVTGLLILKKRFTIKETNKTCEIHQRESLAPQNFKKNESKTTLDHIDICPLINSGSLCYFNTLIQCMYSCKDLKDFFMNDSEMTEVKEILKELFERMAAKDKTINTKEFLKRIVDITSNEEFEDLNQQQDIHSLYLNLINGCFDPNFDVGNIISPDIFDDFAIHNFIFRKLYFLIEISSKESNTEQNKITYEPGNAFLLPTKKFNLYKDLKRYFEKAVFKKKNDNNEEIEVETTKELIRFPDILVLYTPYHEATLPDEIDIHRNIVFDQNIKYRLIAFGCHLGNESSGHYIAIKRMKDNTWAIINDDFITFHSWENVLKYLNYYKIKPTLSFLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF0</accession>
    <name>A0A4Q9LSF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1633p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001633">
        <property type="protein sequence ID" value="TBU10641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1633p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="43327" checksum="1811611BB1085DCA" modified="2019-07-31" version="1">MQNLYLEFTLIFMSDNYILCSSSSEENEENNLTKIEIPKKENLRYYSKKTFSLNFSYENFLFYKNRFIGKNSIPSIYDISFPDGSSWNNQNYIRKQIKKNTAFFHVNKWFSENLNSKFKDILSKKYKKIEEITKKEIKCEIINVIDNTVPITLPISHNFIPKKRNKYDELCSFILDYSKINDLDSLQDKETSISSSCLYLIKESVLSRLLEKDTQIYFEVVFANGIKKYLFYDWMKEAFSYEESILKYMEERIEKNNSNEISIYKKDNKMFFIYFDTCFIANGKKVYCGSLKNNSLIYLEKEGINLITETEVINEKSIDLYISVLNGLELEIGEYILFNKNVYKHDNNGKRFKYTGLESICLKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ7</accession>
    <name>A0A4Q9LSJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1297p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001297">
        <property type="protein sequence ID" value="TBU11257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1297p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="24261" checksum="D252B1540193C67D" modified="2019-07-31" version="1" fragment="single">MTKRETYNLIQSIIDKCLKNKASNNSFDSNNDPFLLSKMNKTSITYWFRLLNYFTVQIKNFKSEFFVDKIQVREFSESIRPKIIFVLKMLVYILRNTFNHELYVIDPNISIYLYSNDLDVAYHSYLYYSEYIVHEIALMNHDSYNNILDIDFSLYETKRYIFDESFKDGDSDVRYEFIDQEFNEIMAEIHKIMEDMKSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP9</accession>
    <name>A0A4Q9LSP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1569p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001569">
        <property type="protein sequence ID" value="TBU10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1569p0020"/>
    <dbReference type="OrthoDB" id="2191774at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="433" mass="51804" checksum="543F76D1156953F5" modified="2019-07-31" version="1" fragment="single">MSIVRFKAHHFRSPNYRYTSLKQYLKNISNHVLSRIDDFFDSNNPSRTEMSDFFENLQNLFLKASQLMKVMEFKREISESTKKIEFLQQSNERFIISADRLAYIFEEIKMTSSYMFDVKYAIKSIFQPENLLPKVIYDFSSFTSQDFKKRLLEYKKSGQNNFYKQNQPEKKFNYLKFKNGFIDSTDKQNIPINSELCINEMERIDLNKKNFEDKELYKEEAEQINFNKDSCEISFVDSNKNNFKSIELLIKIYLKKEDISSFDSYFIKDGILFLKGNYLTYKMALCGEINNCEWKLLDIETHLRDKRITNLIVNNINGIELKFEEENKKKKSFNSLILFNKIVDANYEARNSYECIKEYVKGTFNDFFVSSFDFYLHCFIKDIIFYKEIEINGKKKRIESDAISFFENTVKSEIKNTIEKVQENILRRNKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS8</accession>
    <name>A0A4Q9LSS8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1103p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001103">
        <property type="protein sequence ID" value="TBU11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1103p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23087" checksum="9CC5822B12324652" modified="2019-07-31" version="1">MFELRFGKHSYFLHGYYNLDMIDTNMSESYEDLYVSKISKKNIISLYSISFYNLMPLDYYETVILPAKRTYGYETLIKCIKFEYFHTKNSIDDVSKFMILFTDSHITFEFNFNWFAPYEIFKNYTPAIPIYIHTKLGKCLNLYIIELKRSTDKDFFEILNVIDFPSSYGLLSTKNNEEPNENFTLKNIIDYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV7</accession>
    <name>A0A4Q9LSV7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1149p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001149">
        <property type="protein sequence ID" value="TBU11544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1149p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25589" checksum="AA65A0F442F83746" modified="2019-07-31" version="1">MSEIASMYRINYQTVNSIKRVSDRRSKLTLEIKESLQTYVDLECTKTLTIDRAPETPERRNKLSTIDLRTNYATCFRELEVDNDDKNFVFLDESAYLSVTEARSRNISVVAVMNKYGMIYHKIHERAVNDEDLKLSIKEINESCQPQGILTPIFVIDNARIHQYRGLNDDEKLLRGARTELQLRISICEKFNEKEEHCGSFCRKKLGYLQKAEVGQVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ7</accession>
    <name>A0A4Q9LSZ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1508p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001508">
        <property type="protein sequence ID" value="TBU10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1508p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020483327" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36490" checksum="DBA8576A274C39B9" modified="2019-07-31" version="1">MLLKLRFFIFVLCSIVKADSMRKEIIGKHINIFTAKGDERRLVMADNMLGFSHLDAIVGDMDKVVFEKVKDNRYRITVNGRKMCYFNSRKNIEPCKSEKEEEDGWAVETGGDAFMIRSKYKSKVLGRPRKCLAIDMTKIFGKNSFSVKAAQCSAQDDNQLFLFRDYINPEDPPPQNTNDPDSSESSSSVKEDQPILTAMKEHGCATPSKVETTIVKRPNTPSPPPPQQTYSSSSAPIQQYSVPVQPINSTAYPTAYNTAYNYAYANSTPHQSLPSPTYNRSTSACSTNSLLPPSSSSQYYYVNSNSISNLAAPQTYTTNTLPTLLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT28</accession>
    <name>A0A4Q9LT28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1063p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001063">
        <property type="protein sequence ID" value="TBU11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1063p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="68" mass="8247" checksum="7698641CD45CF295" modified="2019-07-31" version="1">MHKGLRILMKQGEENVKKYGYKRIKEIEEIEEIEEIEEIEEIEEIEEIEEIEEIEEVGEVEEIEEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC0</accession>
    <name>A0A4Q9LTC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1444p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001444">
        <property type="protein sequence ID" value="TBU10991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1444p0040"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29042" checksum="A77B98F093C48D91" modified="2019-07-31" version="1" fragment="single">MKECVMKEIYASIQKYDNIIVTGGTGSGKSTKLPQILYKSGNVIITQPRRVSTVTLAKRISMELKSKIGETVGYKIRFESIVSKNTKIFCVTEGILLKEIETDMLLSNYDYFVLDEIHERTVLIDILLSYLKYLQSIRKIKIILVSATGEIEMLSDYLDFCPVYNILDKKFPIKIIYNDLLKVEDIIMKENKNTLVFLPGINEIEEYSKKLKNLDAEIFILHSTLRERNFEVFKTTETRKIILSTNIAETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF1</accession>
    <name>A0A4Q9LTF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1004p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001004">
        <property type="protein sequence ID" value="TBU11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1004p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="241" mass="28254" checksum="C58044A42D494D34" modified="2019-07-31" version="1">MIYDYKDKRAEFSSLDDTMCVMKNKSLSVVYFSDSEERKYISVNEAVFFLYLKIENNTFGFFSKNHGHDYTRRNNESLDAWHTHLIHISLSLRNRLGVTLKEILENEHAMIRANTRIKPDDNTNENGNGFKENRIVIKYIKTYAKTLQLPLNVEAYIQFIVLKKTVETISFNRRRELETSLCVILGAEMPKQPTSSLKQADNGEDGDKTENRKNILPLILNHNHRERTDNKHKRRVGFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ0</accession>
    <name>A0A4Q9LTJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysophospholipid acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0973p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000973">
        <property type="protein sequence ID" value="TBU11933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0973p0020"/>
    <dbReference type="OrthoDB" id="2189411at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45580" checksum="1CB665620851AD44" modified="2019-07-31" version="1">MNKIVEMPEFRYILALFLTYIITFGLKLTKRTNLFPLFSLCCILIAFGIIDVIFFLVVVFSNLSVLYLFKRTERIRFIMTGSNILGLLLYQQLNNFIKGIYGERLGPNISGPLMMLVIKMYYLGKEYDFSTHTIYNLISYIFYLPSILVGPAPSFKGFIERPKQTKKYILFSLRVLMESFIFMGLHLLIRSKFSVEKMLEMQKSNFFKNFLFLYVFSFGFRCKYYFVWTFAHSVFSLDGYTNQKNIFPLSVEFSTNIKGVTDSWNICTNKWLKDCVFVPLKGYSIFMASLATFFVSAIWHGLNWCYFLMFLSFGLIIPFIRNNIRIYKKYLNDSICKFVCLFQMMAIVSYFSVPFITLDLDKTFSIWKNVNFYGHIFVLLSGFGMLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM8</accession>
    <name>A0A4Q9LTM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1006p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001006">
        <property type="protein sequence ID" value="TBU11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1006p0010"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="4">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="4">
        <location>
            <begin position="256"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="376" mass="41911" checksum="82905D121BC27C76" modified="2019-07-31" version="1">MTWNKDDSNFGIIGIEYQLPSLVVDEVDLAKYLNWEPEKLTIGLELLECGTVIDCEDSISLALSAVDRLMKKYNIDVNSVGRIDVGTESNHDSSKAFKTYLMNLFPGNNSICGLDTTNACYGGTAAFLNAIAWLESSLWDGRYAIVVATDVALYKDLPPLPTTGAGAVAMLLGPTAALKIKRGTLSHHFANTFDFMKPKTLYPHSFLDGKVSVQIYLEAFQKCYEKLNSSYDYMVFHTPYPKLTKKAAVLVGASPDKIEKSLEIPRRNGNSYTASAYMALVSLLSNNIAIGEKILFFSLGSGLASSLFVLEKCGEISTVDIKERLDLRKKISPEELVQRTSRIPELENFVPSDTPIFNGWYLKEINNYKRTYFKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR4</accession>
    <name>A0A4Q9LTR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0988p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000988">
        <property type="protein sequence ID" value="TBU11904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0988p0010"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="28064" checksum="B76C0E8FE6A7C287" modified="2019-07-31" version="1">MSSFTLTITQTIPNPLLSRQLIKVKLAHPNSSTPKKDEITKKLAYLFQTDPSLVIVRNCRTAFGLHETTAEAKIYEEISTLNSTEHSYVIARKTGVVADKIQEKRNIKCLDLYEEICELLLRKKKEINKLISVEKRQSIYHLLLFLPMEEIMDKLKEIEGLIDSSKKLPQGIIESLEYESKMLFTYLTLKIALGKLTNTLDIKDLERIKSLKNNFEIVKERKNEIFDEKVENDVLKCLYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU4</accession>
    <name>A0A4Q9LTU4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_2225p0010</name>
        <name evidence="8" type="ORF">CWI38_1061p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002225">
        <property type="protein sequence ID" value="TBT97503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001061">
        <property type="protein sequence ID" value="TBU11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2225p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1061p0020"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT97503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="365" mass="44110" checksum="2A3FF2190E7B94A1" modified="2019-07-31" version="1">MYLFIGLPYDFDEECNSESLLREIRHLTKSETEIISLPRFRFSSLEFMMKHVEDLDKLEIQTTETFFIILKNVKNKLQPEKKEFGEIYINDSTIDFYIKKFKWSSDRYDDESLLKEILESLHDSYKTLKNSYLQKTQNYEKIVKEYEKMNRETKGNLKEMNISGLINYEEPETQFIKKFYVVVNKSDEKEFLSLLRNIEFIHFDSISVIVSDNDYILFSFVGIKSKENEIKKKIQEKGYFLKNHDLKKGEYEKRQEINNKISKDYEITSNNYKISLNSLFVEIFILMIHIKYLKVYMECVLRYGIPCNYVYFVCWNKFDDYLFNKWKKVIKNWRFSKRISISSSFEESDNELECAFSKIECKFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU6</accession>
    <name>A0A4Q9LTU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1425p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001425">
        <property type="protein sequence ID" value="TBU11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1425p0010"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="744" mass="86455" checksum="54517E22BF2D6FBB" modified="2019-07-31" version="1">MNRKKNNSNDKRKDLEKKKESKRNLKKKNEKNDKEDEKGVNNTIMRLSQPKNDKEDEKEENNSIMRHSQSKNDKEDEKEDYSEEEIIKDLQSKKNLEEEEEKLKTSLILSNQEIETNEENQKTNTTNKEPTERIFTKRIRILFYSTPFIIKISFFIFLSFGCIFLYPVFFDANATVKRIKDVFPYPSTLYKILETLSDLDNSYNTFTAQFGTPSKSPGEVLAEKGARAHSPIIIIPGIISTTLELWKGLEGSDSHFRKKIWGSFDMLKFILSDKKSWCDHMRLENGLDPKGIKVRASQGLGASDFLLPGYWIWSKIIQNLAEVGYDYTNLHLSSFDWRLGMEELEKRDFFFTKLKNEIEFFRKTSGKKVVLLSHSLGTLVCYYFMKWVENSCDFCDQKSETEKNNSKNSDQKCKCNKNWVSENIESILSIAAPFLGSTKAISGMLSGEGKDTAHSGFIESNILDFFLGKEERRELFRGWGSIHSLMPKGGRRFWRNKNVIKIRNGESFDVENVNNVLQQTLNTETYNRINKCHRGNYKDNKNQFNKKENWTNPLLNTLPNAPDLTIYSFYGVGKMSEEGYIYDEIKETKIWEKIEQYFYTSTDNETEIQILNEIMIKEESKDKRYFEISKDVNNSNKNICRGIYMTNGDGTVPLVSLGYMGRKGWRNSILNPYNVKTVVREYEHNPISILKDVRGGPDSSDHVDILGNYNMTIDLIKVVCKYEELQDCIVSELDEVCEKIDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY7</accession>
    <name>A0A4Q9LTY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1424p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001424">
        <property type="protein sequence ID" value="TBU11030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1424p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="30636" checksum="9ED72E813E0F978F" modified="2019-07-31" version="1" fragment="single">MDGIKNFGRKECHTGLFALYVLVGMMGVLLSYIGGMSNEKSVTVFMTKNSIFLICVFVSILFLTNLCFMVSMMCFLGNFVIFLILIIGPFPFWVLFLSQFRILHLIYLILPVYLFTSILLFYYRYCKYIGITRKYLRVSCIILMRNIFQLFIFFSLVFIIFGCVTVLLFYLICRYKDSLVKYIMFDSIIILFSIWSYFICSFLLSTLVSLYIYYKMSTCLADDGINPLYFTFRNIKNHLNDLFLLEFMNKVRDEDTDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU31</accession>
    <name>A0A4Q9LU31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1025p0020</name>
        <name evidence="1" type="ORF">CWI38_1801p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001801">
        <property type="protein sequence ID" value="TBU10386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001025">
        <property type="protein sequence ID" value="TBU11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1025p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1801p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="18089" checksum="4AD2A70D730EF3C7" modified="2019-07-31" version="1" fragment="single">MIYAKNLLCSINVKFIEIDEDIHSKAIIFGENIYFLCMKTCCLINCYNSEEVFKPVAFNSQKCELEILYPDEISLEFEFLNEIICEEKKHIEIFAKEKDLGNLIYFTKLLKFKDSVFKTKSDIFLEILKYLKIFRVKRDRNYKTFIKELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU51</accession>
    <name>A0A4Q9LU51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0874p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000874">
        <property type="protein sequence ID" value="TBU12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0874p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="677" mass="79865" checksum="D88294C814BE4C86" modified="2019-07-31" version="1">MNILLQFFIVYTANRFQNRRIENDGCEGIHAPFSRRQSVTSRGICTTGTDQMRYQCTLGGNGQRIYRNKNYFHGGREEKTDYRSDVRGRDTYHRDTEKTRFVPYTNSSRSSEGQMTGVKEPGNRKNEDSRETMLHSDVQPRVDETRFVFYNNSTRSSGRQMTGVKERGNREYQHSRETMLHSDVQPRVDETRFVYIRNSTYLKAGNEHKTPEREFICLESGLPETRESESGRFHKENKPSYSGLSATINQSESHISSYKNPCSHNFTQNEVNFIPKSKHTNRNENENHGGFINYLCDKFYDEPISSHESSLNESVYHERSEDHRKIIMAWITDIFASTKELKDVSVVQEILKSLKETTNIKDFLQRIDIKLIELDNLLNAVKFEFKYGAKFFQDEIECKSKLIKILNEKFQKKIYCEFPELEKIICFFKRRYSSDKINFKCILPILCLIQLNNSGCKKYEGHANDYFLLGGRYRIFYIVSYIQVIRDLFFSLSPTQDILPKNQNIIKSFMENFSFISSSQEIIEDSCVFELCLFIYSNVFCFVETKELNDWENEYLNLLNSINEAVYGYKIDDKVDIQELYKNIYIIFEQNLSIFKFLLRKLILFHGFRSDDPRYKIIINWAYSTDKENESVSTIFKYIHEFNICCVVFNRSKYAPIFNHIALEKASLFMQSYNLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA0</accession>
    <name>A0A4Q9LUA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exocyst complex component protein Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1337p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001337">
        <property type="protein sequence ID" value="TBU11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1337p0020"/>
    <dbReference type="OrthoDB" id="2196302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="2">
        <location>
            <begin position="468"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="77872" checksum="668D4004874F9240" modified="2019-07-31" version="1">MATFSIEDFKKENFNELVLINDKLKIDFDNLDETKKNLTRLITELDDLRQAIFFKKEKMKNELNKKEIKTVKENIELLTKNIENLKLNHVDCFKEIIDTKKHLDELKLMQRIINLVCDIKKREFEKIENAIKNEDFETLRFLCFAFKTLRDISNFDDESLTENISNYNKKIEKMITETFERAIVEKNRTLLRHSYVCFMEMDKSKYIIKNYMQSLDLFKLKVSEYNHEIPKKIDLDFYENENNPFFIFISKIRKYYDDELSDIESIFPNHLEVIEIINKRIFQDLIQTELENFMKFEDSFLFLMNLKSSYIKVKELQKFILSIYEESIGNTLVDDIFEDYVLNAIRKEETAFEEVFQILVNKKKPKNNYILLNESIYNSNFEYKEIFAKLLCIINFFMERAEILNYSEKNIDEIITFFISKLHRLIEIVINTFSGTETLKLCNLLSYLFLIFSNFFSSFPRKSHLSENFKYFVDDKIQEIIDTRFKISERKVKGLIKAQTMKEYYDEAVNTISIKKITCFLKDENIILNETIPGKNTKDFLTLLLDKIYICYYKHILSLKFTPKKAKILVNDIKYLQKFIKDINLIEVFENYEYFTEVCELIAVDKNDIIMFTTGMFHKIPRNELKKILKCREDYHEIKQSVLEADAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL7</accession>
    <name>A0A4Q9LUL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0794p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000794">
        <property type="protein sequence ID" value="TBU12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0794p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="26185" checksum="A159264157A55958" modified="2019-07-31" version="1">MEVKNTEEEMPIGNKTTKYESEGYVFQCNDNINDPSHKDLWERQFTFQSDEKKQKSSVKEYDSTILINPAINNTFDEKPEIREAAKNDFLKSLLDQPVFISKPLDLSLSLRENHIDENAINTHEIYLKNITDTIDSYIYRIRNDRKSFFTNIKGKLNLEDNLKILRGQAQNVFTAVSDNDFRSQSYNSLRISSEEILIRELNYIKEDDNIKDLRKIIECSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV30</accession>
    <name>A0A4Q9LV30_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="5" type="ORF">CWI38_0891p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000891">
        <property type="protein sequence ID" value="TBU12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV30"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0891p0010"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16887">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19946" checksum="0BBE46F80F2F7495" modified="2019-07-31" version="1">MKRVENVNLTKKITIVSSSIPLTPEEQLENTPATHKWTIYIKSPTDTPLDYISTVTYKLHDTFITPLVETKYPFVLTETGWGEFNINVRISFIDINEKPISLNHFLKLYNENGESGCTNETHDEIIFRSPCNDLYRSLMENDIKEDNLTEKEEEEGYNIDNAIEYMLKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV36</accession>
    <name>A0A4Q9LV36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1183p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001183">
        <property type="protein sequence ID" value="TBU11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1183p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="779" mass="92372" checksum="DCDE9020C43DF5EC" modified="2019-07-31" version="1">MNFFSARFKKRLFEYTFLHSLIIFLYASCLLDSVSPYKYIYGFIKNEKLKIRFFTGNQETETYSVQNDVDFKLTLLNDESTLFDEKTSAFTYGKNNFISFEVLDNILSLELSDNPNGKIECNFNLYYSLKLTRDIFEIPDEVNYIDIKNILFSLKYLKAVKNKNMTLFLQALIVKVFLNHKKPTLKEHFTCMEGLLDLGFWCKIDLQIKEIFLSSFLNIYMVKYIFQAGNLIISENIEEFYYISIFDEHIPYKNIFINSGRLFLLLEKLLHDSFILKFFQILLEEINLKSLIVEGFIEYDIPDTKFSFLIFSLNTFKSIALYNFIRSSSSLFTEKVCVACRNDIEFLRLEFLNITMNVLQLFLEGKKLKGLVLKNVRMPENILPIDRYIQFPEILDYLVLENIEIDLILWKTLFLKLNVCTLILSFNSISTEKSFINEFYRFSKPKNVLCFEVSFCTSEISKEFCNALFRFQFLRTLKLQNYETDEQTELYLVEAIKNMDELDNLTIKQCYFSTENYSSLFMKRGMKTLHFENDFLGEKILKIDFAQNYRSLKSISFLNMTIEGTGLNEIFRLENLEYLSLSSCVLEQIIDWKPWNFKSFKLRFLYLNDLNLEIINNLNILSRLIYLEVLDISYCMVEPGYLTSLNMMCNIRLRILISKSNVLGFEDLNRIKKFEVLENLNLLGCKFQDCNFYELGIDCMFLNSLKILNLQYVKMGIEDFRYLKRFANLNKLSLSPFTPYIFAEKDCWICLLTLKKLSKCQIKFAINDEILYYFYINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV52</accession>
    <name>A0A4Q9LV52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1095p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001095">
        <property type="protein sequence ID" value="TBU11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1095p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="28588" checksum="3DA93EECF7C73AA0" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAITLPSSSYTTIKPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRTVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV55</accession>
    <name>A0A4Q9LV55_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0711p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000711">
        <property type="protein sequence ID" value="TBU12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV55"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0711p0030"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="38447" checksum="AA1E92CB4EC072B6" modified="2019-07-31" version="1">MSKNKKNNDISNKNDNKFNNCSTNTTKYMKDESSNKNDNKFNNCSTNTTKDTKNNISYKLDSIPQTEIEKTMDEVLKKSKYNLMLKRQERFYKQDFDKKMQRIKKIKSKNYRKIRRRTKLKSETTNGGEGLNQREVINNNDDYIDDCTDDSGVSQSDSNFKENNFEYEDVSDTSTSENCKEIVKNVFPISENEKEFKEEKKEIVEEEMPKQEEIYLPGWGNWAGFGLKDTKTSTNTTVNVTDGIKNYKRKDFQKSHVLINEKVKNSHEKYQVELPFGYSKENFSLKVQTPLSKEWNTLRIFNKFVKSNTTENKEKETENFVYRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV65</accession>
    <name>A0A4Q9LV65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0708p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000708">
        <property type="protein sequence ID" value="TBU12569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0708p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="154" mass="17084" checksum="968C1F02C691950F" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVP1</accession>
    <name>A0A4Q9LVP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1086p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001086">
        <property type="protein sequence ID" value="TBU11680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1086p0020"/>
    <dbReference type="OrthoDB" id="2196005at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13153" checksum="9E26A7A2E5429C77" modified="2019-07-31" version="1">MEEKNKELASKNVLLKEEIKKLSDLHTELLKNNIKNNYFCNRTHMKMIAILDENIKAIENILKDTVDFKTKLEENTNLKNDDRILKEKNKLITNEDKKPRKKRNIVTFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW0</accession>
    <name>A0A4Q9LVW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LSM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0605p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000605">
        <property type="protein sequence ID" value="TBU12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0605p0010"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8491" checksum="D1D736F8DBF71CC5" modified="2019-07-31" version="1">MMKTTPKDLSDLTNQYVKITVTKNRNFIGKLVGYDVHMNVVISDVTLPSKETRNLYTVIRGDTIETITPFQEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW33</accession>
    <name>A0A4Q9LW33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0607p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000607">
        <property type="protein sequence ID" value="TBU12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0607p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7114" checksum="75C6645B9D24AB8B" modified="2019-07-31" version="1">MPPEREANQINICKSSEKRTKIGPRKTLIDAIENDPSLYNKNGEKLLRSPGSLRAVAPFSCSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW36</accession>
    <name>A0A4Q9LW36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1017p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001017">
        <property type="protein sequence ID" value="TBU11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1017p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020665167" evidence="3">
        <location>
            <begin position="19"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="541"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="817" mass="96548" checksum="169606B5A97CBD3C" modified="2019-07-31" version="1">MIIFLSFFIFAIKCEILGIDFSDEMRAAQNIRSRRVVYKINGSLSRPTILDLKEMSPTKFLSYFTIEDLSDIFCFESKDLCEKVPYLVILENKEKHFKIPNLESPLNFTALNFLFIKYLNLENNKFKCVLSKRSYLTKEQSQQLFQSFHKADYKVSMVVPESLCFLADYISALPIETEEEVKKNSENEKNDEKTENEVKADSEVKTEKDEKSDKEQKDENEKNEKKDEKEKDNNKYEGRNYLVISTRGIKSVFSMYSVKKTEKKVNFKNLFHLESEDFSDKTIKSTFYSIVEDITVTNFKKEFLESKGSSVEIPTLICYPRDKTVTQENNNFLFCDLSKIIKKIIEGIIRNDDIYKPLDIKTYNLNKEVKFVLFNTFFDLKEIKNIFLKIILEKKTKFENMKEEIKSKIENKEFKTLFCSNFVEMKMFQNIFPFDFETKYTNKDSISFGAAYLGEKHVKIQDERILYPTSDTLFGNSKSNKIIENVIKEIKIRNDFKNTLEKFEGQNLLKNFSEFSDTEIGEIIEKAKKQFSNLKEMENFISLIKNKIEENSKRIREKERKAKEIERRGEGVKQLDNLISELEKENLFADLEDFSKENITNEDIKDHSKEDISKENTTKDNTTKDNINKENTTKENINKYNINKENTTKDNTTKDNINKENITRDVNTTIPTDTSTKEVKNIGSEHLVELRDVFVSVKTWFENNKENKEIGHSEFLNQFVNLKSKHRIITTRIQRMKEEKERIEKEKLEKEKLEKEEKERIEKEEKDKDNKDKEKDNKDKDNKEKEKEKEDIPTLPSEENEVLPPFNETPSFEKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW58</accession>
    <name>A0A4Q9LW58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0570p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000570">
        <property type="protein sequence ID" value="TBU12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0570p0050"/>
    <dbReference type="OrthoDB" id="2197364at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="30734" checksum="D809B9776C7C28F0" modified="2019-07-31" version="1" fragment="single">MRYEYTKADLLINYVKFEDRKHHFEKILGARNYCHTPNDENLMDFYSRYIDVMIWHFRNAYSFTDLYQQIIKIMCTLNIKFNAHFISKYLKFFVLKCCLNCNSSITGYSKVMIFIVKEYPFNFLQNICSEFLCLIMNFIYHEEIIELFKNTFKLKGTNLYRWLIFLKENDFLQSLFERLEKGEEVYNTCRIILSVLNVSCMLLGNKILRIEEWKNVGFLNEISDKSMFLIELFLMQRSYRILNVLYNILALILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC2</accession>
    <name>A0A4Q9LWC2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0553p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000553">
        <property type="protein sequence ID" value="TBU13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0553p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26097" checksum="621E0EECA3871AF7" modified="2019-07-31" version="1">MSMNISRASLKEIFKLENLIDLRLKCCFFQPFSDPNFTSFMSRNIRALDFYGANLKDIKCISILNNLSCVESLDLSDTGLPPGYLVNLSSNCNLSLRSLSYELNILDKNDLSRIEKLVVLEELKLSKCKLLGCSFSEIGDFCGFFNSLINLDLEFVEIKIEDFQYFKRFKHLKKLRCRHFGFDLDVLKCFFVSSNINKFSTDNIDEETFNSSLGKILYEKNIDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN5</accession>
    <name>A0A4Q9LWN5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI38_0382p0030</name>
        <name evidence="15" type="ORF">CWI38_0512p0040</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000512">
        <property type="protein sequence ID" value="TBU13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWN5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0512p0040"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="125"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU13603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="541" mass="63784" checksum="CC7582F5E3101979" modified="2019-07-31" version="1">MKRRYNNVEKTFLHDAVDYISMGSRSLKRDEFTRSFEPISPCDMKPSDVFYIFIFIIRYYLLFPIRLTLFILGTLLFIFLFLFALIFKEEGVMESGFLFYSKVFVKSFGAKVTHHGNKNRIDYPHVFVANHTSFLDFLVLSSHKFCHACVSESHGGLFGFLFKVILFKNGSVLFKRSEKQDREKVLKIMKNHIKRNKAPLLIFPEGTCVNNKYTVLFQKGAFELGVPVCPVAIKYNRSLMDPYWNRRKHSFTEHLFYLMSRWRLEADVYWLEPMSKLEDESVHEFSERVKRKISEVAGLESVIWNGYFKNSPIMKDREILREAYRQAYLKYVVHWKNDDSESFKYLEKYKSADEKNDYDHDLDKQQNILYFGKFTYKEYLNIVLIEYIKLKSSKTDHFESMVLKGDCVRDKWWGYEYRNSGNFSKCKCYMKKMIRVENNSSKSSVQAILNKECAEIRVDTGIKIHITFVEVGITSQDSLQIVENMKLSKYDLLPNGVGLDSGPNAEGRIEMHEEPIHPIKQSNNKQDGVKQENTKMFYFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN9</accession>
    <name>A0A4Q9LWN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0648p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000648">
        <property type="protein sequence ID" value="TBU12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0648p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="616" mass="72373" checksum="72FDA833043A694F" modified="2019-07-31" version="1">MFFHIIFCLCSLQENSEILLTDPTIAENTHIDLICLRRSNSYVENYLKKIDFRISKEKLEEIGSIICFCMELSENYNDKSDYDYLLLYVSSIFYIIFISDAIHYFQCNPELFFNVSTFLKLYKYLNQVQNHESFLVNLTLDFLINKPEFMSLLKYRGLESDIDSIKKMLPELTLNIKRSCTQNSRLDVDIWENIQINLDIHNPVSFRLSEYLQNASFERIFIFFLKIKTDVALINITALWDVDPKINPYKLIIDQKFLDETFLTEEWFRKKYSAMVNQNSAAELMKLVLEPFINGVLMDKKSLECIFGLSRKDFSNTSTLVDEKFPQILLELFAEKTNINLLKNLYCFLKKIIKPEIYNFIPIVICLKCLCFKHEFSSDMKLQRIILEIIFFIAILKRNNTEFEEIDIENRLQKEYLRFLKHDIIVKNIVCEKDTNGDPLISKIIPKTLNFLQTAVYVQYFADGKFLVLFSIALDTKHKEFNINMNDSFEKRMKKILICLMEDELKDLDLKGSVCVPSTESKSLLETAMTSTKPQGEIFEKQARVPSEGSNEIFKKDSDKEKVNLPISEENQKRLPETEKKNQINTWKIVLVASIGLAIAILLFGYWFFFRKKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP7</accession>
    <name>A0A4Q9LWP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory component Sin3 of histone regulatory component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0879p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000879">
        <property type="protein sequence ID" value="TBU12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0879p0010"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="5">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="870" mass="101482" checksum="FF6D5F0CE57FBE68" modified="2019-07-31" version="1">MVKDQEKERSTHTPDYTEKKRIYPEPSPSRYSGIPGNVMIRPGPPPVKFVPRMSKPPKTEEPDLNDALMYLTQVKEEFKGDNSSYDEFLEVMRDYKQSKLDAAGVVSAVSSLFRERKHLIQGFNDFLPKNYRIDLEAPPHRIPLPPKPYYDSYKRPIPPFARPPFKPQEDDPHKQRMAFDYIKKVKRRLEATPEIYSNFIQTLNSYRNTQEPTHQIVTRIKKILWDHPDLIDEFIEFLPSHPHPPPPHGKDRERQESFERIKLIMKEKGIYSEFLKCLNLYNQDLIQGKDLLFLVRPLIRQENLIDSFKEYLNYKETDIPPSTFKNLSTYNKIGSYRILPDKYRTVQKHEVLNTICVGCPTFSSEDSNFVTHKKNINQEALFRVEDERYEAEMIIQRCYSLITALEGLFMKITDDLGLKTNILEKKMEENENQDEEEKVENNEDEENMENTNLDISIEIDEIDMPPALILEVLNRIYGDKSPEILEGLLYRPFVSIPVVLKRLYLLSKNWKRQIRERNKLWREIVVKNFYKALDVQSIDFKANEKKVLSERIFLRTLREEGFTSKIVEKTVLNDLKELLGVLINNLEDNEDEINSFFKELIEKLGNDGHFYGNGTLCVIIRLLLLFGERIYEVGSICMKYEEIIHLVKDFLSQIIDYGVFEDKMRIITGCKGYKLITADKVLNKILRLGISMLKDEEGREVVKGLGVEIKGIEDVVEEINEESGNIVESISVEENINQTNESFSENNEESIEESEEGGIENNEENTEIPSNLRGDVYKVLIKGNQISMVKTASEVNDFKKYIESFIKLEVNEDFVRNNVFVSVDSKRKMSDSYINYGIKCKVGEGYKLHFVEETEDFLMKKGVKRGKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT1</accession>
    <name>A0A4Q9LWT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory subunit B of Ser/Thr protein phosphatase 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0502p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000502">
        <property type="protein sequence ID" value="TBU13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0502p0010"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="28375" checksum="7DDDECE43EADA662" modified="2019-07-31" version="1" fragment="single">MWTNTDIVQIANLSSTTYNNTELITFVTFKNQKLYVGRADGKFECYNDPQTKHYELQSHVSEFDYLESSDIQEKIVCAEIIQDGGISDILFLSNEKSIKVWNCKLDIPTAKIISKEVNIQPVTNNKNREAKNVIPRKSKLMYKSGSYKFDMLKEQRNIHLYTINSLHSSLNSEYLLSSDYLKINLWCTRNMDKAFCIIDIKPTRYEELAYVITSSRFKCDDDMVFGYSTSKGEINIQDLRIKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWX6</accession>
    <name>A0A4Q9LWX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0606p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000606">
        <property type="protein sequence ID" value="TBU12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0606p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="467" mass="55223" checksum="6E3A3D1B5796A1FE" modified="2019-07-31" version="1">MVLNPTTTNLEPNCNQRHVFTYKKGNFINFDLLNQILQSNTNENSQQCGIIESDFELSYFLKLSKDILEISDNLNNFKFKCMLTVLKCLKAVKHKNNTLNSSIGKNIEFLSLKNLLVPNDSLALLLEKEELDGLVLHDVKTVENFRFIDECLNLNEKIDYVDFENVDIKFCRSLMLFEGLETLKLYDYKFFYISIERMKYLEDLIIPRSSYEVTEDFKDETKLHQNIFLKIKSLTEIILINCEIKYLDMDKIFELEKLETLKINNCYVHNFHSDDLICFSSRNLKYLDLEDKSVDLSDNSHFLSELNCLEYLRVSHSILPLDHLIDLNRKSHLTLKALIYEHIRLNVWDLMGIEKLEVLEKLSFQYCTFLDTDSYNFKNYYKFFHSLKILNISGAKISLQDVKYIKNFKKLKKISIVYSNMVLRLNSNLFLSLPLSELYITDQNNKLLDKQRIKDCVYEYSSLRVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX29</accession>
    <name>A0A4Q9LX29_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0815p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000815">
        <property type="protein sequence ID" value="TBU12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX29"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0815p0050"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15123" checksum="C1AF203C311CD091" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX64</accession>
    <name>A0A4Q9LX64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1860p0010</name>
        <name evidence="3" type="ORF">CWI38_0479p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001860">
        <property type="protein sequence ID" value="TBT98191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000479">
        <property type="protein sequence ID" value="TBU13284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX64"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1860p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0479p0030"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="321" mass="37853" checksum="21A3036AFA68C821" modified="2019-07-31" version="1">MQTKISKRELHGIKILKKIASGAFGEIYIAYDEIRNKKIAIKVESKSHRGLLKYEYKIYKVLGKDTYNFVCQVYGFTSVIMNGENHNAMLMDLLGPSLENLFVYCDKKFSLKTVLMLGDLMLNRIEYLHYRHLIHRDIKPDNFAFGYEKSNKNNLFILDFGLTKYYRDPSTYNHIPMKDGKSLTGTARYASINTHCGLEQSRRDDLESLGYCLIYFLKGCLPWQNLQAEDKKSKYLAIKRVKMSVSVDTLCKDLPIEIKKFLEYSHKLEFEEMPNYLYLKDLLNDAMKYNNFRHDFEWDWIIKSKNDPKFQDKLANGFKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ9</accession>
    <name>A0A4Q9LXJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0530p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000530">
        <property type="protein sequence ID" value="TBU13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0530p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="23809" checksum="70C5B08AD79B9866" modified="2019-07-31" version="1">MFETLDSCNEIFEEKLNDLEISIKYPENERTTMLRSECKDLVDICLSLIKYKKYYKEDLKKFIFLRNKYFKLNIVTDNESEKIPFIQESERELDCRIKSNELRLYSLVRNHNIKNISNKINEIVNINDYIKCVVDMQDQNIDRLSHIMGETKFKSRNTVKELEVTYIRKKNKKRIIFYILGSLLSIFLIYKFILKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK2</accession>
    <name>A0A4Q9LYK2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0316p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000316">
        <property type="protein sequence ID" value="TBU15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYK2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0316p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="677" mass="78779" checksum="7C3479AE527ED63B" modified="2019-07-31" version="1">MFQHVRTINQQHKIINSFNLQTVTTYTKSHVFQYSIQNLSLLFVSPILPDILKIVEYENIIFVISTDLCIRKIERGRITIEKKIFENFNEIIPSFEDRTEKEVHFKTNITLTVCNSIIVISYMKKIYLFSFLLEKLNSYELSSCILSSFHPLSYKNKIIIYDENQKIILFNINKKKIIHQFHCLENEFNNYSNIENINNNIHFAQSSNPHSVLLYSHNIIFLINLQTDEILLRFESPNITSISISPSNTHIICTTITNELLIYNTYYKKNTHLFSVYNDGIFLPTEEDILLVTDNSCLKTLKLNKSKFEAIIERPRCLKNVVGINYIDGGVVIASKQGILYYSLIKEEQSYFAKIKIKLDVNEDNSNLKYYNGMEFTDLAPLIFNSFGTTGFIVLNSYIYKLSSKKLSYFLYEPSLSSINISKCSNFIIIGTYKGSIYILTIKSKSIMSEFSTTNSPIKYVSMCIVTDRIILCYKNILEIRNISGELIYTKDFSCIINITSNYSFIAIGNCNGIDILCYKTGKLCRSLQIKNIKSIEFSNLNNYIAVMTGKCQIECCKVSEFTEADHDFVSSHNNIFILDILSGKVLQKIFLNNEVEYFKWSSDDAFIIIKYKDNDEIFIYFDNEIFDIDYNLNYSEINVKNQICVENENKFDYMQELCLKTLSYLDYERNDLFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK4</accession>
    <name>A0A4Q9LYK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0560p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000560">
        <property type="protein sequence ID" value="TBU13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYK4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0560p0020"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="211" mass="25567" checksum="0DA8F20C6DA2E9F9" modified="2019-07-31" version="1">MKELEENENKLVIRIGKVTKNVKQLITDLRKVFEPHVALKIQEHNNDLIEKYIPIIHQFFLSHFFVFTEKNGEILLRISNYLHHGPTYFFKIENFKNIFEINKCLSQKWFKKDPIVTFSGDDCYEQNIFKNLEFFKNEIKDENILRNIHLHFENKIIYFRHYFIKKEEKDSIKIILEEIGPSISMSFIKEEDGFFNQKNINLDLNKYLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ80</accession>
    <name>A0A4Q9LZ80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0354p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000354">
        <property type="protein sequence ID" value="TBU13716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0354p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020806820" evidence="2">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="17101" checksum="CA7D3DA5D9EF26BE" modified="2019-07-31" version="1">MLFNIKTFTLIFKCLLIASSPYIKTPSNQIQNTDHNYTMEQMCDKMSDIKLLRKQYREKERNLLRHNITSKVRRRLNFKPKETAVDVIDEEKLKINSQRKLPINFQKRLQHIIEERKNRKQSEISNNRGTNENNERKPKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC8</accession>
    <name>A0A4Q9LZC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0225p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000225">
        <property type="protein sequence ID" value="TBU18879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0225p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021008787" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13212" checksum="4B6DC7D5025993AD" modified="2019-07-31" version="1">MFLLYIMMVFTINPLLGEVQKSTNNDNIREIKLYYKIPEGLRLEDINFKHDDHSISIMYYKKMESEDITYWTRVKGLKYKYVNSQIKNSRISLENIKLVVTLECEYENDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI2</accession>
    <name>A0A4Q9LZI2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0321p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000321">
        <property type="protein sequence ID" value="TBU14723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0321p0010"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU14723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="967" mass="114152" checksum="4DAEF33A3AAFF38E" modified="2019-07-31" version="1">MILKTIKNNLLLFFILYRLNNSFLLKTVFEPDEIWQNLEPINYIFYTKGTLTWDWMIGIRSVNYVLVYLIPLYFFKIFSDVFRFCCLFYIRNNFNIFLFLNFIFLCLLCCFTAVLCFCKLTDSGRFLTNEKTKNRNQIINCPEDDVALKCMGKKEVLKRRKTNFQNNNLERFGLRQIIGFLSHPNILNNLYLVVLVLLESKYQFFDEMVVKYTILPLYGKYGYLVSKIVNGIIAGLADYLIIKLGTIYKADEDTLIYVTALSHGLWLYSPRSHINSFELFMAVLCLYALETFKTPTISLLCLCFIFYLRSSILFLSGVHIFFAVFQKNYSSIEDDKMRKNKKNLPECNNLQQEKLECNETNNNDCNQSKDRTENVNPVTCSKLHSIVSYLKLVKVCCICLNIIRMIKNKFVEAFFKIRNIFCSKTDSKIDENLKKSANEKNIDFNNYKEYFYSEKDNEQLKLADNQVNYKQDNKYNHYEENISYNDAKECYKPEDKSNDYKTKESIKDTKNKDIYKSDDTHGQSKIKGHIDTEVSVINFKINDFEDAEDLDLYNRYGRRVLSNIMVFIKNIPCCLLLVLLMALVDSYFYKELTFVPFVFFNVNVRWSVSEVFGEQHVLSYVWFFIVLTGFTGTFLFLNFNANQNIAISVLIYLIFYSALKHKEMRFIVPVIPFCNLLCAIGINKMSYRNTGGINYIRKKLYSGVLYVGLYITFFIGLYIGLVHQNTFDISFFMKTEVEKILTKSFFAANTDLDFYKNKNIKNSERNKIEISVDFQNVLGKDISVVQNTKNIEILYFVCPYSLPVYSFICYENVNIKSVSRNPDITVKMKDLVVCKRFDGQKIIFFEYEMYMDLLEATSESYKTQLESKKDKNNKIDNDKIVDEKVEKEMRNNNNRDDTDNAFIDKCINNTFEGYDYILIYKHIFEKYSNVFYEYEIINTFKYMHVLFEEEKGIYMLVLKSKKYNNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL7</accession>
    <name>A0A4Q9LZL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0489p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000489">
        <property type="protein sequence ID" value="TBU13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0489p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="17880" checksum="BF7AD0A8FE5EF5B2" modified="2019-07-31" version="1">MFLLAANKTYVSASDRIQKSVVKYLFGLESENSELTLSLGLRLITNIDTCLYTDLMQNNTKNFKHIKNTYEKYTYDTRIIPMKLLKDLKNSFLKDNRTLLEQITPLRFYDFKNIRYNDFTRLLKILKEEKFIQLQDIVAFFIEKSRNPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M068</accession>
    <name>A0A4Q9M068_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0385p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000385">
        <property type="protein sequence ID" value="TBU13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M068"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0385p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10421" checksum="5518659C7237E0B9" modified="2019-07-31" version="1">MPRRAGKELEICVIKTVGIHGELTLELKQAGNEEDSELTININEDSDLREEKIVVKRSEAKLTCEMLNASLNTLKKLYFINTHTPTRTWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0F9</accession>
    <name>A0A4Q9M0F9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative subunit alpha of transcription initiation factor IIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0410p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000410">
        <property type="protein sequence ID" value="TBU13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0F9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0F9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0410p0020"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="36277" checksum="B67161E169CCB4A1" modified="2019-07-31" version="1">MEYEEIMKKLIKKTMRMFYETHHAVIMDILLEYMIMYDNEICEKMKMLNKEFNRLVVKLKDDKLLKAETKIETKSDGRQLLRCVYFIVYSEIKDVIKYKIFKMSRFLEQEIKNTEKLQGYKCSSCFKEFGVLEAQRLLENFIFKCDECSGKLIENKGKTSIDDPHMLHSIMMNELSEVISMLKELDKHNIPSIDYFQVLALRKGKEMMKSSSLKSEYKICEIQEEEEKQEIFAENEEKNVELNFKVFQKQEESKNEVKAESSIFVNVNGVSKLFSQITEEDKEKMNEDEYEKYFEIFLKQNEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0M1</accession>
    <name>A0A4Q9M0M1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0244p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000244">
        <property type="protein sequence ID" value="TBU18377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0M1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0244p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="394" mass="46950" checksum="2A3CBE0598D8301F" modified="2019-07-31" version="1" fragment="single">MNSDILFFRENRTEVSFDQEISTDCWLEIIHDCDIKHVNQENYLFRYTKENFVSFEELNNILFSNATIKKGIVECSYELSHILKMTNDITDMPINMSNYQFKCILTTLKYLKAVENKNMVKLFQALIFYDFVYHLNNGSKSKPLFLYGAFQDDFFQNFEFVIMKNFLFAFLNIFMMNYSFENGNLILLDKCRVSQDISLLNKNIPYKNIVIANFKVVYIFENILRNCYILYSFQALLNFLDIKSLIVDNYINLEIYEQNYNFAIFSIKTFKSISISNFTNQSSLGFLDKLGSVIRNDLEFLCLMNLQISRNAISLFLNQKRLKGLVLRNLIQIEDIDFIQDYTDCSKKLEYIEFKNVILKDTWWNYFLQVANVRKIILYFCTLLQQKNFMKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X2</accession>
    <name>A0A4Q9M0X2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0352p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000352">
        <property type="protein sequence ID" value="TBU13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0X2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0352p0010"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="16419" checksum="0ADB21E62E5E8835" modified="2019-07-31" version="1" fragment="single">VIHYDIPVDPLNFFHRSGRTGRNGNTGEVFLFLMENEIKYINYLKIKNIDTEEYECKDTSKHTSNIEIDNEITELATKAVISYLRSYKEHALSYLLNIKDLNQEEIAQAYFLKKIPENIFYTKNKNRFGIYKTAKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z1</accession>
    <name>A0A4Q9M0Z1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0359p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000359">
        <property type="protein sequence ID" value="TBU13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0359p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="24440" checksum="0E3EA42D52396C28" modified="2019-07-31" version="1">MINWGIRSHSVQEILDNEYAEIRVDIRIKTDVKIRNNRPDIFILDKKKNKITLIEYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHIKRLEIPLNVEAYIQSIALKKTVETISFDRRRGLESGLNAEESWERASMGVILRAEMHEEPTPPLKEEKGEEDGVRILKPKNTTPLISQGGTTLEEPTNNINKESDLEEETTVVKQVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M126</accession>
    <name>A0A4Q9M126_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0347p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000347">
        <property type="protein sequence ID" value="TBU13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M126"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0347p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="176" mass="20746" checksum="F2AAE1BF5B5DC953" modified="2019-07-31" version="1">MRFGKSFFERFNFRFISKKSILRIFFKSFFRKTNFEPLSSNPSSELSSGNSSLEQPKDLYNLMIHRFSDWEEKSAQIKKMTSYLKEIQELIILVENHSGSKLEIISEHINELHPNIGLLNQARCLFGDKYFAMQTEGINIELFEVMIAEMIKNKFETNVVKIFKCIEKELQPMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M165</accession>
    <name>A0A4Q9M165_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0076p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M165"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0020"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475:SF1">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="343" mass="39658" checksum="4AEF84EEFB18A562" modified="2019-07-31" version="1">MPKIVSCKNRQEKKILTAYLKTCQYPAVYSKEEKRLLRQKVEYFTLFRDEICFKSRDHLIRAFFGFETALIQQITQIEHSVAHICVNKRIALIIKKYYGILKAYIKEYVKDCEACSRLNSLKTIQPIYINHIIKKYDLFMMDCVDFRDTAIKMINFKNALLEAFLTDLNVKIILVRPRNLKAQGQVEPVNQTLNRWLANKLHETGGKGWIEHLNNVVCAYNRTIHKATNKSPFMLFFEQPGLNNLLSRSIIVENEAGKIVPAIDIDPDIVSAEENAATQWILEIASDLHEEVTETVITTTTIIAYDHESDGKIGSDVAKPFKNYREKIIRSNNLNRLNMDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J3</accession>
    <name>A0A4Q9M1J3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0058p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000058">
        <property type="protein sequence ID" value="TBU20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0058p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="32055" checksum="B4896312AFD6FF7C" modified="2019-07-31" version="1">MLLQLLDLLISKVENTTTTHLVLKKNFLKVKYRLLEELKNVGDSFRWLKRGTLGPEMKQCRQNGDDYIKNHLLKEECNNDRRVFWGAGDMCQHIGKSGKLNIMKQLHHAEIKVNTRTKTYVKIWNIRSDFFLDKKKNKNTDIEVGNIYQDLLKIVETEKLRKYDSRPMRCILFVIEFKEHKSRTKRQQIPHNIETYIHSIILKKTVKKISFDLRRGLEKLRKSERTHPLKQAKNDENAVKINIRNNTPDISGERTTCDELTININKKSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Z0</accession>
    <name>A0A4Q9M1Z0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0034p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Z0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12712" checksum="254C3890F58DE2E7" modified="2019-07-31" version="1">MNPFIFMKTEYILFRIERYVYFNDRNPVRKLSILSEKPEFFQESYNSSIQNNYFTHEIIKQGNTVENNAFKISFFCLDKNDAQISKESNDLKNELGFKENRKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M272</accession>
    <name>A0A4Q9M272_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0204p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000204">
        <property type="protein sequence ID" value="TBU19525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M272"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M272"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0204p0010"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="488" mass="57330" checksum="E76F50565AD62008" modified="2019-07-31" version="1">MKISKKMLTKSEKIIFKKIRKFVTNTGINVIPRVAGGWVRDKLFGNNSNDIDIALDTMSGYEFATKLKDYYSEDPFFSRIGKIKENPEQSKHLETAVMKINCIFVDFVCLRSELYMDSRIPQIKIGTPKDDALRRDLTINSLFYNLMTQEIEDFTEKGIQDLKNKIIRTPLCPLITFRDDPLRILRIMRFAARFNFKIVPEIKIALQNKEIHDALLTKISIERIQIEINKIINFKRSSMVFLWVFKYNLYNSIFKDDTVYDNKKAKLFIKIISQIKSIFVLPVKKIKSTKKNNSYRIQDKDLDLKDVLEHHHPVNCVILNIYKGIFLNIGVIVQSKKPSFKNYLICKENLKFPNKFCDLIQKIEENFLFLEKNIAIFDLTILNCIILIRKMKNSWLETFLLFISIQKLNENVVLEEKAVLFLSFICKNNLCHCYDIIPLVRGKDVGRLTNDKTKYSVLLEKAIEHQILHKSKSKREILEYLRSELNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C3</accession>
    <name>A0A4Q9M2C3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0090p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000090">
        <property type="protein sequence ID" value="TBU20317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0090p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="32276" checksum="2216E853CF46D3F6" modified="2019-07-31" version="1">MLLSWSTVVRETGISRGVLIIKVVIIRVVIKGVLVTEIEGEVNNSDCNYKGVIIRKFLTVNDLNEKVSEKFEDIYRQKEKTLKRFFDSDFYYIKLENPALSSEMNQLIYDHYNPLIGHPKPVLSTKLKLSGKLPGIHPIKDLIPILKQSFNFFSTLKEKCKIKAAWKFSSGFFENKDEKKMQFKSTRTLDTEDYIQEYSSTCKFSSKDSIRLPGFESEIKIQFLIVSFSDNDLVQFKISDKDLNITKIVEMTEKSSNTERVIALTDSEHTIGRFLKSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3S9</accession>
    <name>A0A4Q9M3S9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0118p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3S9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="11510" checksum="8CA0B5BB43B3E9F5" modified="2019-07-31" version="1" fragment="single">DNDFHKIKEAPVYVAMVQVYVYDNCGDEKCENDSKKIFKNDTKNDSMNRLNDYSSILNTKLIKRQVKNEKGNVQKNKRKKRWEGISDPKERLSHLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3T4</accession>
    <name>A0A4Q9M3T4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0079p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000079">
        <property type="protein sequence ID" value="TBU20382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3T4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0079p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="456" mass="52721" checksum="BEE4065194DAFA26" modified="2019-07-31" version="1">MLTLVSVMSKSIEICGNSSDKNVSLYIRIFYERKIVQEILKKQRLHLCLTHRAVILTGLGKEPREYYTDYVLNWSKTKSLAANTSEYLYDAIRALLVKNNLNLHPGCKEHFYLPRTELGRDLIIASTTLRSSGKGKEISTRCASILKYRLVEEVPKKNLEEAQVKKLYNKIEKQKQRQKLDSKLYNAKKNEHVSIGDSSRWPKKKNIRPRNEAGADGMCQHSTRCEKMLSHEYTRPHNEIVGCLHLLLLNRYKSHSVQEFLHNEYAEIRVDIRIKTDFGLIYKCSVEIIPYVMTWDGIVTNTIKIPMNVEAYIRSIVLKKTVETISFDRRRGLDSGLNAEGSWYRTSMGVIKRAEMHEEPTLILKQASRGEDFLEEPTINICEESEIEEETVAAKESSFDVHFKQNIHPVLKSVNGIFSNNTLINQEMNKINKYLSITTLASSTERYDILQNQRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3V8</accession>
    <name>A0A4Q9M3V8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0012p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000012">
        <property type="protein sequence ID" value="TBU20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3V8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0012p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6297" checksum="FCB88989C37197EA" modified="2019-07-31" version="1">MKEFYVLSQKLILSKIENRNISRILNLERIMLTTPYMYNNICNDSYDNYTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M464</accession>
    <name>A0A4Q9M464_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0003p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M464"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13693" checksum="7F7E9F3DBA059757" modified="2019-07-31" version="1">MDFTVYRNIFQNIYFSELFCTSHEYNIKKLLLVEINIVEKDLRFIANLKKLKSVELRACKIDQTPYSFLKFVFENEYLIELKYYYLNDNLSKETIKFIKENFKPRRIVVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M486</accession>
    <name>A0A4Q9M486_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0020p0040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000020">
        <property type="protein sequence ID" value="TBU20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M486"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M486"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0020p0040"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45415" checksum="7E7666FC163E7C09" modified="2019-07-31" version="1">MNDFELIKTTGTGTFGRVYLARLKRIYTTSDKFFAIKMMRKSDIIRLRQVEHVYNEKILLSYMRTSPFIVKLYSTFHYNNMLCMVLEYVPGGELFYWLKKMGSFGLYATRFYTCEVLLALQDLHLRNIIYRDLKPENILLTASGHIKLTDFGFSKSIDTLTYTVCGTPEYMAPEKLLGEGHSKEVDYWSLGILIHEMLTGNPPFYNESHYIIYQRILNENIILSSCIDKLAGNLIERLVERNVSKRLGSCNGVSEIMEHPFFYGVDWYKYRMLQVKPPIVPFVRSAGDTSNFQVYEEEVEGVKDKEGVKDKEGVKDKEGVKDKEGVKDKEVEEVLYYRVEGVKDRDIRVLYYRFIRYKDIRVDMEVVECKEVLFILYILKGVIYSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M546</accession>
    <name>A0A4Q9M546_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1965p0010</name>
        <name evidence="3" type="ORF">CWI38_0032p0060</name>
        <name evidence="2" type="ORF">CWI38_0048p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001965">
        <property type="protein sequence ID" value="TBT97983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M546"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1965p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="287" mass="33656" checksum="4F64701CB0FF88C0" modified="2019-07-31" version="1">MKFFLVFNAILGSGLKPQKGKVNLDKATNCYEKHDFSVENTESEENKSYGNTLYLYQAFQIYSENKSMRDNFSQGSPKPSIGFSERATPTGKSYIPEEKKIKMNRFLDISDNVLSVLTTKNRGIQCNPELMNEISKETFEKVKFLQDRVKKFVNSTNESQFNDLLIESYQLFKMMILIHLCSDIITLLVSYLPILIDYELHFSKHNGLIIFPKPKFDLIKKKFSSKVIKPMTVYSIKKMFENKFYNTSDEIYWLTDTYVDFIKNIFCFLNIFFVNVEKIYPNELNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5B2</accession>
    <name>A0A4Q9M5B2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0026p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5B2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="383" mass="45553" checksum="DE8067F21AD77D00" modified="2019-07-31" version="1">MWWISIRNNNFKKTRCTILITLILYLEVYYCFPIERKIIFHRLSSTYNANEHNNFAAISDSNFNTKEDHYRDDSETSFCFLYSKDFIKLTIFDIKKFPLNFKGAKGNKEIPNDDNLDNIHIVEECTIRMFELFLFSHYLPPKNLSVKDFLNFLHLFEAMNIEFDQKLARIIHVLSITLLNSKNMYSFGFKEELVGIFLINLLSQKYSFFVFETLAEVFFIDMNLEYFCQKSHFGNYNLPKCILERFENIDCNCLYIGEYSFFAHLYQTRSKIIQNNMISLNLNFELQNKTVIFNFGSSNNSLIIKYIFIFELKLYDDIEFIPIDLVNLKNLIIFERESKVIDTLMSAEFTEILKFATEKEIDISGLSTTENLQEDRKKEYKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5U2</accession>
    <name>A0A4Q9M5U2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0010p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000010">
        <property type="protein sequence ID" value="TBU20906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5U2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5U2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0010p0010"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25315" checksum="7B14C7ADA5B87D3A" modified="2019-07-31" version="1">MAHNEYDMASEVYSEVLSAAENIYDQNDPNLCKIYLEYAASLIRGSEEHFVNELEKMVSKRTVGSSRDDDLNIAWDVLEISKSVFIANKDHNDLAQTFYLLGDILLLNNDFTGAITEYVSSIVEIKKCAGKNTLSESEVFYKMATCYEFMEEYEKCVEFLIKMKGISREVDEELNCKIKEVLYKKGEKEKKEKIARGEVTEEESESGEVIDINMNKRQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUU9</accession>
    <name>A0A4V2JUU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0701p0010</name>
        <name evidence="10" type="ORF">CWI38_0234p0020</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000701">
        <property type="protein sequence ID" value="TBU01472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000234">
        <property type="protein sequence ID" value="TBU18631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUU9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0701p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0234p0020"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU01472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="478" mass="55822" checksum="EDD97BC8649AF65F" modified="2019-07-31" version="1">MVFFFDNDKVVPKKEIEIDKELLANKTNERLEISNEKLEMFKKFTKMVNSNGKDLESKHFVYNKYSINNETNICAGGETLSEKQIQNFEKEFPKINFDANFYFNNFSIHEKVSEENRIDNRTNNLSPSDIEVKEEVINKQKSEKIVEETDDNIDTLENILETNEEKKFSSLPKNGLYDTTSSKICSDLEVQDLFKNKADLSPIEQKINNCFNQNNTINMNIQPNNNNNNNNFLNKQNIKEQEYTNYEMMQQFDSNHIDQRAVESILLDFRFRGAISSFNNRGHVSREMRHRFRKDSSTVLTPGVSIPKSNNIPTNFMNFGNPNLIHQQMNYTNLPMIRNPTIPIPGIENGPMNMGMNMAMNMGMNMNVNMHDSECEMEPQFSSSGMPNTIEKWDAIRRLIKRKKNREIPTMQRNPITTVVQTQKNVCAHCGTEKTSLWRRFEGMFVCNACGLYYKMHGVRRPNFLKTDNIRRRKRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JV17</accession>
    <name>A0A4V2JV17_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0501p0010</name>
        <name evidence="13" type="ORF">CWI38_0291p0010</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000501">
        <property type="protein sequence ID" value="TBU02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000291">
        <property type="protein sequence ID" value="TBU17007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JV17"/>
    <dbReference type="STRING" id="1176355.A0A4V2JV17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0501p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0291p0010"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU17007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="80" mass="9404" checksum="DA34B8D68D3271BD" modified="2019-07-31" version="1">MGRKKTRRSQIKTKKRSDRMENRFNCPECNNESVVKCKIEKSSRLGYAYCTLCEASYKCSVNNLSHPVDVYSSWIDNFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVW5</accession>
    <name>A0A4V2JVW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrP8 U5-snRNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2735p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002735">
        <property type="protein sequence ID" value="TBU05632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVW5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2735p0010"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U5-snRNA-binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="348" mass="38779" checksum="FE5BC47459860F19" modified="2019-07-31" version="1" fragment="single">VSNKDMLEGVSNTTTDQHPYSTSTYNPLNTNTYNQHPLNPNNINTYNQHPVNTNTYNQHPLNPNNINNNTVILPSGNTLVLTVSTSSINLLKLQVNRLCIRSIGSTFIKTISKWNKILISFLCYYREAVTCIDIINKLENKIKSVIKKGINSKMPNRFPPVIFYSPLYCGGLNMYSCSGCGVNILKYINSWNKEIKEGEEAYKEMEGIISRSVKGYNDIGYVGGYSKREIVGGVSKREIVGGYNEREMVGGVSKREVVGGVNEREIVGGVSKEYYSKDSRGGYNEREIVGGVSKEYYSKDGRGGVSKREIVGGVSKEYYSKDSRGGYNEREIVGGVSKEYYSKDSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX24</accession>
    <name>A0A4V2JX24_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1967p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001967">
        <property type="protein sequence ID" value="TBU10172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX24"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1967p0020"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41108" checksum="97C0CEE60DD7AB5B" modified="2019-07-31" version="1">MEKDISHELQETALNILNKHIPGNTWCIELFTKGNTNTTLKCTHLAGISKNNKILILKIFKEDSNKLIDREREHNNILMLHSYKLAPQIIFTFSNGFCIEYVPGTDLEPCNLKKYSTEIAKKIKEWHSLPIKGNTILFHTLINWYNQAFSTHHKILEELQILKIINNLKIKIENKKCKLAFCHNDLLASNIIVGEDNKIYFIDYEYSGINYASFDIANHFCEYAGYSNSFENIPCEIEIKKFLEIYCFKDSLILYEEVLLFIPVAHIFWGLWGLNKRGDFDFYGYAISKIKEGVRCYEKEGVSVCGVLCYEKGGVSVCGVLCYEKLEKIFKFLILKRRVLSKERVLNVIIKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX53</accession>
    <name>A0A4V2JX53_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1738p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001738">
        <property type="protein sequence ID" value="TBU10472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX53"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1738p0010"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="11">
        <location>
            <begin position="534"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="715" mass="81578" checksum="53D8EA54680CCC46" modified="2019-07-31" version="1" fragment="single">NLNLNPNTNPSISKPTPSPFRDRPIETNRVLFKEMIEGKWKEGSACLRLKMDLNSTDPLMYDLVAYRIIKGVSHYRTKYKYNVYPSYDYTHCICDSIENITHSFCSREFFIRRNVYYWVLNELNLFKPFQWEFNRLNIKGVILSKRKLTDLSIKYNKWDDPRLFTICGLRRRGVTKESINRFVKQCGLTYSYTVIDKKLFERIVREELSVICKKVMCVVEGLKVLIVDKGVLEGGDNDSRLEGVNDSRLEGVSDSRLEGVNDKSNELEGVNDSINKQQGVKDSIHKQQGVINSIDKQQGVNDSTNKQQGVNDSTNEQQGVNDSIDKQQGVNECTNKQQGVNNLSSKQQGVKDSIHNQKGVNNSTNKQQGVINNHIEQHPVNNLFNNNTLYDKASSLLGYTITPSNSEICFIENKDFNLEGGSNFYRLSKDRCMGLYGYCTIKYKGMIECEDSEGSVSNNDNISNTISNLSISNLSISNTKDISNHNPNTNPNTNPNTNPNTNPNTNPNTNPNTYTNNTPCLVVEKCLCKAKKYVHWVKEEEYKEVEIRMYDYENGGLNIFKGKIRIEDLKGVKIEDKFQFMRVGYFCLDEESDVSKGRYVFNLTLRGVSKGRYVVGCWVLVYLLVDKRVLVLLLVDNRVLIILPMNNRVLIILLINNSSNKEWKCVIITLIGLCITNTPLFINTNTNTPLFINTNTNTPFLLSNTNTPLFNDIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF8</accession>
    <name>A0A4V2JXF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1095p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001095">
        <property type="protein sequence ID" value="TBU11662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1095p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="265" mass="30261" checksum="EA0663B788A18D81" modified="2019-07-31" version="1">MIVYVLKMAIVYGVISKVIKIVKFILEKSWTRTIKSIFYLIHLYYKITCKLAQFLKKIIVMIYNSCLLPICVYGGIEYKRIPTGYSKWQKSYRLFAISLYGIHIFSEKTITTLRKNICFKDIGAFFGFTEIGHDNMEAGINELEAQDTNNQPKIILPNKTDKKSAKNNTSATKNKIQSKKTVKINKPYVINHNIPTDNEISCNGLKRKNPKIDPYDTIVVETLDESILKKVQQSHDQGDITSLSTSEILGFHIADGIYDGISFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT5</accession>
    <name>A0A4V2JXT5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CWI38_0560p0030</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="PITK01000560">
        <property type="protein sequence ID" value="TBU13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0560p0030"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="648" mass="75897" checksum="B88F8245D64E1402" modified="2019-07-31" version="1">MTLEELKGNLYEIQKDFIEKAKCVIENNEIGIFSSPTGTGKTISLLLSVYNYFIPPKEESNKYTYFGLNSENKKLMEQLFGQSDRITKVFYCSRTHTQLNQAINELKRFDSNVNSIILGSRKLYCVNKKVNKTNVELEIINEQCKALISKNDCEFYCNFESQNETDIIDIEELIKKGKEKKFCPYYFAKIYSKKCEIVFLPYTVLFSKEGRRSANIDISDSIIIVDEAHNIYESVIQMNTVTISFEIVKKYFKAFEDYYLKYESRMSEVNLKRIKNICEILEKIWKFHENFANNLETKTESSSQEKNEECIVVNDFLIKSRLHNYNLLELEEYLHNSGIAYKLEGFNTNLHLQLFNITKFLVLLIMSDCHGRIFYDNKKIRFTPLDPKIYFEDIFVCKSLILAGGTMEPIDNLLNLFKERTVKYYYYDSICTNFISFILSTGPSNKEIKLNYKTRESPEILKDIVYTIFNLSNTVKKGGIICFLPSKYYLKILKETIINLEKNNFKFIKKILYDDTSSFLEFKNLVFEESVIFFSVMGGKMSEGINFNDYLCRLLIIIGIPYPTVNTELKERIKYHGNDYSTLIAMKTVNQALGRALRHKTDYASIVLIDSRYNNLISKISPWIARKTRKCKFIQILSEIKHFLNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY81</accession>
    <name>A0A4V2JY81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0144p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0010"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052276">
        <property type="entry name" value="Diphthamide-biosynth_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240:SF10">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="236" mass="28586" checksum="008204391916D235" modified="2019-07-31" version="1">MVEENLYKILNLKQFSSSKEIRKAFIKKALESHPHRTGFNSEEVFIRIKNAYDKLSDSTFKLNYDKTLLQESKKYESNEKYKNSNIKRNNSNDERIFETKKEYFNINNENINGVFRDKNVDKYKEEYDDFNIKINGKNCKEKKFKSNINLENLVKIYCKSGDLNLLKFKCKRFGKIKRFIVKESFVFIEFRNLDSLKLFMETEKNNFLIRRLFYFDEELYKTESELFDKLKNLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD2</accession>
    <name>A0A4V2JYD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0043p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24494" checksum="7B2AA4E6D552C6F5" modified="2019-07-31" version="1">MNTTAFENEIQKECILCEINLQMGVLNTFIINEEMNLNEKILFRYSGMSQKELDLKDGFLSTNIIKASNSDDNSFLYDLYENIEKKSVFIEVSIDIFICCSNNLNCDTRNIEIHKIFDFILKNIFCYSMVVFKLPSCLDSDYMKKFFDKLFSDDILVNIFIKTVSNEFDKIYVALGEIQRLVSIKAKENKPMDHPVNIIVFNLLFSEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM2</accession>
    <name>A0A4V6MVM2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0819p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000819">
        <property type="protein sequence ID" value="TBU12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0819p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="493" mass="58288" checksum="8FA3EAB2268690AB" modified="2019-07-31" version="1">MNIFFSIHIINICFSNIEASLPRKKAKHEHIEHIGAEYSERKSKVESAKDCGFEEYNELRRSNNRKELEGAKYDNKEQNSEENLTLSSQNSFFQKNYLFPKNTESKPVDKASEVFGIGDQAIKNVQSFPKTKLPPFRTAFPKKFYDYDSTESIKTKPMAQSVSESQFPGLDICTGSDNLAKENSHNYFFENKFFCSTNAQEHRTEVVNQDSELNEEINSNLGENTGPLKDYHAQKEHDMGIDFLKAHESINKHDNSTDSDLMEPGILSDLLNKNSIFYRFEFKTNEDLEEIYKNHLLNYSLELKKTEIHLIVSEIRYLISTFEMKKDHNIAKGHVLLIHYYYNIIKILGNLIFGNNQEANKEKHEEKRYEVAALIQKRIFFMRKLLSELFILFQNYINKAHILEKNHYILKMRFIFRFPFDLDSKPNNIFLAEIIHEIYFKNMSYHVEIYFQQKLTALFYEYYCINIYFDNVLAIIDSYKIYNNLLKFLELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L0I5</accession>
    <name>A0A4Q9L0I5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0978p0030</name>
        <name evidence="2" type="ORF">CWI38_0888p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000978">
        <property type="protein sequence ID" value="TBU00526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000888">
        <property type="protein sequence ID" value="TBU12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L0I5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L0I5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0978p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0888p0020"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22852" checksum="62909C3E2F93F585" modified="2019-07-31" version="1">MKKISSLMKSNLFAHAFKMMYEAEEAQKYLKPNIETQIQMAIVQNRKTDLRRYNAQRCNEVAVVFVSGDGEPPIDRDLLVHLRPEDTTIPETRRIEYRHRNLDALSYTLLFSYGEQTWGVNIKLYNARRKGVNAHKNVTLKQYYSYYLQLRDELDPLLRAGRLTQQYVVDAYCKAEVDDLNYALTHQKKLRAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L192</accession>
    <name>A0A4Q9L192_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0794p0010</name>
        <name evidence="2" type="ORF">CWI38_1040p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000794">
        <property type="protein sequence ID" value="TBU01143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001040">
        <property type="protein sequence ID" value="TBU11785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L192"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L192"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0794p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1040p0040"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="180" mass="20888" checksum="4B5B589659C4A709" modified="2019-07-31" version="1">MEKEISKEEVELYDRQIRIFGFETQKKLLNFTVLILDQENQNRFIAGEIIKNFVLLGVKKIGYNKYAFDSFEKLSPIKITEINENIICDIVNHQNVRYNDYSLTVFIDLKPEVALNNCVFICSKCFSFYFLDQEETCKENCGTKESSVANDCLLGAIFVQEAVKKIKGDIYLSKYTLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2R6</accession>
    <name>A0A4Q9L2R6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0742p0010</name>
        <name evidence="2" type="ORF">CWI38_0675p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000742">
        <property type="protein sequence ID" value="TBU01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000675">
        <property type="protein sequence ID" value="TBU12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2R6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0742p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0675p0040"/>
    <dbReference type="OrthoDB" id="2189745at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="141" mass="16701" checksum="16D4683D6C901223" modified="2019-07-31" version="1">MTLTKDTRFKDLSEDIKLRLSSIYQHSRTRPVFRPIPDVLEASSDLMISISSLPTKQLTENYMKLSVAANRLKDDENNTFCPKSLKNNLKKQIDCLQRDIFMFTEFMHEKNFISFLQDIYMRIAGKYICTRNMFIKKNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L815</accession>
    <name>A0A4Q9L815_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0289p0030</name>
        <name evidence="3" type="ORF">CWI38_0097p0060</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000289">
        <property type="protein sequence ID" value="TBU03476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000097">
        <property type="protein sequence ID" value="TBU20283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L815"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L815"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0289p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0097p0060"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38002" checksum="F0157C80E3660805" modified="2019-07-31" version="1">MKYRIIKSLNTHQKVLAVAHHNNEILVGGTSRTLESYNITTNERTTFCEFSKAVRSISVNNECIAGGSYDGTVVIFTPKPFQIEGPDTEIKGISISNHNMLAVATRGKTVWIYKIKDNVEENRKGNDDFSNTKNIKDNDRKYTDNTKNTSTNQHNIKNNPYSYHELYCILNDHTQDVKGVKWLSTSLYSYGYDCTIKRYSINIINNNYELIQDIKDFKNTIWDITFTNHSTMIACTEDGYLYIYTLDMAWELKCKIFASNYPIYSICSSKDYIFYVLNKRSVGILDTQFMCKEILIDLHTSDINSLFYCEVSDMLITGGDDGITNAIEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEM9</accession>
    <name>A0A4Q9LEM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2593p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002593">
        <property type="protein sequence ID" value="TBU06354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2593p0010"/>
    <dbReference type="OrthoDB" id="2201125at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="15642" checksum="13861D288BE4A999" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFK7</accession>
    <name>A0A4Q9LFK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2502p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002502">
        <property type="protein sequence ID" value="TBU06818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2502p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="54" mass="6301" checksum="E4FF7C14FB731EC4" modified="2019-07-31" version="1">MRIKIDEKKRRVMRNSLGLLNLSLRVAIKIFVTNVINIRIPISSPYVEGVSRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGJ9</accession>
    <name>A0A4Q9LGJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2497p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002497">
        <property type="protein sequence ID" value="TBU06846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2497p0020"/>
    <dbReference type="OrthoDB" id="2193421at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="46243" checksum="2338361CEB56837F" modified="2019-07-31" version="1">MDFKNEIDLCLENIKDRKWIKENKKRMRIFFLNNKEALEELNLMINTPRNYCVLRAFEKLEIPVQENVLIDSLNTRNNLNQYMYGLIFYLHQKKLISSECMDIIKEKFKEVKNYDEIMSETEKRCILERIESDRIKYKRDREMKLKVYDREIELNKLYRKTEILKEEEILNAKCISKNLKILYILDFDYILFMKVNNLERKSDYNLIKDSINSMQNILKTIYDETYDNLYEKRLDLQRKEFLKLVKEKFAEKYIEMTNKNYFDRFLDRDLYIEACKVTDVQISRVVSILRKLFEKSLNFVLVTSATMSQVLAEMTFFRIDCEFSKNVTVFREFDKCINSFYKDFDKIIYLGYRDHDIGNFFFKENLYFFEKRISYDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHB3</accession>
    <name>A0A4Q9LHB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2390p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002390">
        <property type="protein sequence ID" value="TBU07509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2390p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="215" mass="25399" checksum="836A16CC937A1382" modified="2019-07-31" version="1" fragment="single">LNDVLDKNSNTIIEIIFVVCSFGLNLNDDYLKILNIMSIGIKRRNVNSIVSKLKSSTNLDIDFITDLGFLFESNEIKKIVRAYNSTASFDRNCLNTETFSQNFSSELEKILNEKNFIIQIIEYYSGIFSDTKLQFFNTTVRPKYVDKQYNSLITRSKELFRRKDQDNDNIQDLQKLRLDAFSLFHFVLNYCYNHDINSKKFLRLLETEFKKLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHJ1</accession>
    <name>A0A4Q9LHJ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2196p0010</name>
        <name evidence="2" type="ORF">CWI38_2480p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002196">
        <property type="protein sequence ID" value="TBT97556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002480">
        <property type="protein sequence ID" value="TBU06945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHJ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2196p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2480p0010"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21887" checksum="ABE933413AFB8CAB" modified="2019-07-31" version="1">MIDENVEEIQKRLLNIQEELDNEYIEYTKRDFELKLSHYTQIKPILDQRDLIFADLKNPWELCFLNYEMGCELLPIDKNNKVIADFIENIKVWYEENYFCCVEISFTDTNPYFSNKKLLKKFSVLSEETENTKINWTEKINAPIFQFFEEEEDILETFDVLYEMYVNAIFYLSLAEELESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJG1</accession>
    <name>A0A4Q9LJG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2275p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002275">
        <property type="protein sequence ID" value="TBU08333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2275p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="810" mass="97236" checksum="D8C2037DD234FC34" modified="2019-07-31" version="1" fragment="single">LLTKKMRIIYIRDNKKITKIFNLSMLLIYLVFISYNCRCITRSIKYSVIVMIYAKNLLCSINVKFIEIDEDIHSKAIIFGENIYFLCMKTCCLINCYNSEEVFKPVAFNSQKCELEILYPDEISLEFEFLNEIICEEKKHIEIFAKEKDLGNLIYFTKLLKFKDSVFKTKSDIFLEILKYLKIFRVKRDRNYKTFIKELVFSAIMFNTKNFLKETSKLSLNTKEYDNSHIRDIIECFCKFNLIKKHFLYETFHQYHPTEFSDSISFHKEWKKDKKIVTMQFIKLHYILYWYNYLLNSNFRKIWNILIKIFYIEKLHINFLLFRQNMNIDTLISSLPQKFKKFSLIIWEGEVQILDTLRKYGYFDTIKKFKISFAPFSRLIFEKIEYFKNVEKLTLVLQEIPYNDIINLEKIEELKLIKILKIILCKFIDVQSKAASVSLLGKNNNIYVDLSEEIIIDDSENMLENFCTYNFYPYLTGIDLNIFKVNYTLTDFSKIFQCNLISRLKIEFENSKFNYLNNYEFLLSFTNLKYLYFSNIKLTDQLLTVILKHQKLISILFSLFEFCNEINHEMWNFSNVSVLHVGFFNLVNSLNGNFFFFIMKFQNLKHLCFEFSIEFCCEGEIFVSIDKLLDYENVESAKQNLNLPRLISFSYKKDFDFLNRVGFSILHVISFFFDLRCIESLVYNVECLYSNDVDIFTTFKVLSSLDLSIQRNDLNLKFLEKILQSNIKKTLFKLKIISDKYFYLELLSILNFQMLKIFEIAAIFMDENIKKYLEILSGMNLIICEIYVLTKISEINYFYFRKSYVFRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL28</accession>
    <name>A0A4Q9LL28_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2311p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002311">
        <property type="protein sequence ID" value="TBU08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2311p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22844" checksum="51633A63BFC64B42" modified="2019-07-31" version="1">MFKLKNLEILLLINCAFERISGLDLFNIEVLKLKEFSLNGISYSIWENYDILGKLDGLENLTLSYIPIKQAYFSKLNIMCNLSLKILCLDDYFLEFIDLQRMEKLEVLENLYLCNRKFQSCYFHYLGNNCRFFQILQILDLSFLKINLDDLKYIMKFENKRKLSLMLSNFDLMSVKNFLVALPLNELSIGCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLL4</accession>
    <name>A0A4Q9LLL4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0511p0020</name>
        <name evidence="3" type="ORF">CWI38_2215p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000511">
        <property type="protein sequence ID" value="TBU02308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002215">
        <property type="protein sequence ID" value="TBU08836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0511p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2215p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU08836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="186" mass="22167" checksum="62FD4D71295115C3" modified="2019-07-31" version="1">MNKSSFAENYKKNLEKILLKYSNINDEKEIGIDLFERKSNNRKSNNNELNNRKLRNKESINTELRDIKSDRKLRNKELNNKELNNRKLNNGKLRKRASINRKSNNTESNNRKSNNKESSNRKLNVEEDNYYNAFFSKSHKRCLTQQKDFKTVDKLIGSYGFNIIFDTLFSDCNFDTLYEKVIDYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLN8</accession>
    <name>A0A4Q9LLN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2169p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002169">
        <property type="protein sequence ID" value="TBU09238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLN8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2169p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="512" mass="60084" checksum="1063DE81C974EE10" modified="2019-07-31" version="1">MIRTLKSGKSGGLSGIRNEFLKLCPGIFINELTNLYNQIIMIHKIPESWKKHRIKPIPKEGKEFRPISLIEKSRKLFEKLILNKMHFKLIKQQAGFKKEHRTLNHALTLDNELRCSNGSLICVSLDIRKAYDSVNRIKLYEKLAKLQKFPFRDTLLIATLIENNRYTIEKTKESSAFKNACVGLPQGSILSPSLFNVFIDDLLEYMPANCRKKLLLYADDILIFSNRIDEIHEMIANIERHAKDNSYLLNAKKCFYNTNIKIEIRVNNIEIVKQSPIKYLGYYFNLKCADTKKNLKIARTNALKATAILKSALRKNIFNNSGDIFRYMLRGYISYVRPHIDYPITLLGLNKTFTEDCDRIQKGIIKNLFGIYYKTPSRIIYGIFPIETIKQRSRRLSLINTHKILNGKRTSLYTNFRNNNTKIFKTMKKTYLEHINEEMVQGTTIKFSNTISELKKKNLQKNLDIFKYFKNLKNFNWNTETKERLGELLEVVNFENKKEKFEEILKIMNDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLX7</accession>
    <name>A0A4Q9LLX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2165p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002165">
        <property type="protein sequence ID" value="TBU09274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLX7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2165p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="18564" checksum="04B45D2C17BE48B3" modified="2019-07-31" version="1" fragment="single">QALTPAQPQALTPARTPALPLAQPQAQPPAQPQALTPAQPQALTPARTPALPLAQPQAQPPAQPQALTPAQPQALTPARTPAQPQALTPARTPALPLALTPALTPARTPAPPLAQPQAQPPAQPQAQPPAQPQAQPQAQPPAPGTVPALAPGTGSTEAERKAEEEKKEEKEEEEKEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMH9</accession>
    <name>A0A4Q9LMH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2228p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002228">
        <property type="protein sequence ID" value="TBU08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2228p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020812812" evidence="1">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="36546" checksum="64B82C2D963FC154" modified="2019-07-31" version="1" fragment="single">MCLSLIIVILFFPEISNTHLRRIKMIFEHKNVGRIRIRDSNISRFKKIEKNRRNNKGNLNVCERVSKILLQHKKKVKSGSKCTSKVFSSFKHDKTGSVRNIDDISFNEEELERIYYSDDDDKKHEYFLSKISEILEKKIIFELDSRMNCLEKFSTYKTLKNQNLKIIFFWLQTLSKELFKIDNDESLMSFKEIIVAQAAEEKVYGFIVHLKANIALFVRFNFEYLSDCETNLSQINIIVGEYLIELFLNDFQDKVFHFFPQFQTALNFIFNSENSYNHLNLYSALPTFLLIIIAEDTYRKLQIDSRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNV6</accession>
    <name>A0A4Q9LNV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2024p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002024">
        <property type="protein sequence ID" value="TBU10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2024p0010"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13333" checksum="87D1E354EA9B0246" modified="2019-07-31" version="1">MYRVRKGQFFEVSYCDRRSNLTLEIKESLQTYVDLECTKTLYELAEWVKSKFNVDVSTSTIDRALREFHYTIKRVTVVPGRRNTLSIIELRTNYATCFRELEVDNDEKTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNY9</accession>
    <name>A0A4Q9LNY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2063p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002063">
        <property type="protein sequence ID" value="TBU10054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2063p0020"/>
    <dbReference type="OrthoDB" id="2193379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14313" checksum="5AB7276CB50EE65B" modified="2019-07-31" version="1" fragment="single">MCICIPTRIIEDSRRIPTRSSFGEIQSKFISRIERLCHTRLNAKNLFSAIHQPAISLINYHIGVLRLEPADFSKLDDAVRAVMVKNKIHLRPGCKERLYLPRKELGRGLHSVESRSEHMLLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP38</accession>
    <name>A0A4Q9LP38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0524p0020</name>
        <name evidence="2" type="ORF">CWI38_1969p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001969">
        <property type="protein sequence ID" value="TBU10169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000524">
        <property type="protein sequence ID" value="TBU13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0524p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1969p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9513" checksum="9E24B3012F9B812F" modified="2019-07-31" version="1">MENKENIENERIDNISKPDENATTAEPTRKNFINEGNEMKQKEDKKGIWSKIKGMVGKKMKDESGNGKKDETKNDIGNKETKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPE6</accession>
    <name>A0A4Q9LPE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2171p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002171">
        <property type="protein sequence ID" value="TBU09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2171p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020379884" evidence="2">
        <location>
            <begin position="25"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="650" mass="75767" checksum="E92827EF843DAE64" modified="2019-07-31" version="1" fragment="single">MKNILIYFCLHLHVLIFHSHYIYCEKVSKSEGHEISSGRKHEIKQPKKIQNSTLKNIDVEIKKFNVQNMFEKGFLMNDIIIEEKVPNNKKMAHITSNQPILKNKYTDSRNNHNINKQLKLYDELNISSKYYDTLASKSCNFKPISLQYTSTIPKILSKKKLREFTITPNLHQIIDSKCNKMEEKNSLSASYHPYREKVFDNVLNQHSKLHQKRSNVTAKNTKTNKDSKSNNETIKTSIEPNDKTFEDTRLNSYKPKIKSIKFFSESLKNEIIHENNYEKDLLITSPIHSNDKDISNNTHNTQLILSGNVQNEIVIPNYNKPPNDIITEEIKAEDQKIPIIQVENPNSFVTNNFTQNENITKQEISLKPSVTDILNEHGETTIDSKIEYIDKRTGMAIYHPLISKGIVDSVHAQHISEDSNENEKENENEILNKYFNWYKKNVNEDTQYNDILYVLHDPTQNEALMNHNIDINTIVDQNGNPIPDAKSKREILVNFLLYYKSFVNPNGQDRHPHAKKRHDISKKTYAISDINKNFKEDVNQNIQKPINYSDLDSAETHSNEKYDKFVQIFQNQENTETLNSLNNNDFNENHDIFPPQYFSNTYPGATEDKIDFYPNTTESNMTKSKYPDNKSYMPGVHSNIYRFSNTDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPP7</accession>
    <name>A0A4Q9LPP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1782p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001782">
        <property type="protein sequence ID" value="TBU10409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPP7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1782p0020"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="51"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="346"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="584" mass="66801" checksum="148B8E29F9B28E33" modified="2019-07-31" version="1">MQKEEKSDWQVIKEVFQKYVLAIPTIKLMIIPTFACVLISKFLEVHLGESLQDFSKKMAGNLEETSFNFLLLRFMITMCFLNMFSLLQGYIFAGPIQKSFRLAAKSTFKKYMSLSHTNFHALGSGEIHSSIERKSKAVADILDVIVLHIFPVVSIIVFSGFKIFFSLGKFPAIMLFVALVLYALITIRITKYRNKIRKLLNISVNDSSNLLYDRLINFDIILAYNNQELELQKYDDSLKPIQTHSTRLMKALHILNFVQRMVFSFINVLVIYCGINGILMDKITSDSLILYITISKTLSSNLSKLGYIYHRYTQAITDAKMTHENFFEISSQKALKYDLGKFENEIKFKEINFYRGSRMILNNISFTIFKGEKVAIAGKNGSGKSTLIKILLGFHEFQGKIFIDNTDFNSININSLRKIIGYVPQDGNILNESIKYNMQYGDFEAKNDRIVEVSDDFHIHDSIMKIDNSYLAVAGERGEKLSGGEKQKVALVRAVLKNPDILILDEPTASLDKESETDVLNVLLSQYSDKTLIMIIHNIGLLKSFDKVVFLSPNFGIEVGSHSELLERKGEYYNFYMQKILTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ96</accession>
    <name>A0A4Q9LQ96_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0218p0050</name>
        <name evidence="2" type="ORF">CWI38_1629p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001629">
        <property type="protein sequence ID" value="TBU10649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000218">
        <property type="protein sequence ID" value="TBU19127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ96"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0218p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1629p0020"/>
    <dbReference type="OrthoDB" id="2193051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31936" checksum="37AFF8834C397F28" modified="2019-07-31" version="1">MYIKIIIVIFLIIFEIFFIFFVIQNKIIYKSFLSTGEIKIGETMTLVTSDNQSIDVHFIDNNSDTDIYFFHGAIMKPKVHNKICNKLTKNNKFNIFALIYRGYSNLYKNASSSEIGIMLDIKTFHDYISKNRNTSKKIIIGHSLGCAASLYFLSLFNSTEQFLCVLENPFYSFKTVLYEKWYHAFISFLVVSDWPNYLRIEKINKENCKFLFIISGKDEYISNKNTEKLLNHLKNNSYEKFFMENATHFDCGKYEEYYETIFTFIEKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC8</accession>
    <name>A0A4Q9LQC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1901p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001901">
        <property type="protein sequence ID" value="TBU10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1901p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020288863" evidence="1">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="422" mass="49862" checksum="88D1D1FBDC438E21" modified="2019-07-31" version="1">MIFVHLVFYILITNCFNGEDIHLKDLDNMIINILDGNMEGIKDKKTLDYYLLIPKNGIKSIEMEEIYEFMYDPEIKKINVFHFNLVINNNQNDLILEKYFEMLDSTTENIDLGFDDVTQNQISLGLKFHILHPELFSSCKHFISSIFDEKKKFADFLVSISDGKSNVFLKTKPKNSLDISIIFNRKISKKYQEMLRKIILKFCNEKYKQLSSKINSDKIILMIRKGNRNENVRNILLEVHKLHNSFKIYRFFINKDKKITNNLSGFDTDKPEVYKLIYTFCCERIDKKSQSKSKPEYIDAEDENLLLCEFSKNVNKNKINYFKAIFFRTISIQYKKCKKDEKIEAYKKEDTRAEEAYELVILNPISNIFYTLNFYCDMDNNILASFGHSKTVKNQTKGVYMPIEWNISVFLKFILDNPESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQP2</accession>
    <name>A0A4Q9LQP2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1532p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001532">
        <property type="protein sequence ID" value="TBU10819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1532p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="48063" checksum="29D0A6EE7A8F968C" modified="2019-07-31" version="1" fragment="single">FTTIICYIVYNNVGSESLEKYRPELLFNLISFGKFIEIYISDVEIRSLVKESLIFCLFEIFQLKENFDFSKNKNVRKAVERFIDPKNILNSMVNEKPRLTCSKKNDSIFHKLGNELSNATFEYFFVFFSVLKSDFFAKNFNIVLGSTVGSSVTDINVDESFQNSTKTAINILIEVINDFDHDKRLKILEYISKPIFKDVLKNQSELNTIFDFPRNRITSYSDPKVSRFPGVFIELFCQEADVNRINVLYDFLIEKTKQEYHKYISAIICLKAFCLKDGILEQNKAIRIIMEFIFLAKVLKIESEKTVNVNEIQKYRNAYIDAMKKAIGLQNMKYAINTDTGFLDESKVPRSSILLEIFVLVDLFSNDEFKKFLNAEINKKLGGNQNKMPRNSDQVKTDYLIYIFKHENTLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQS7</accession>
    <name>A0A4Q9LQS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1509p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001509">
        <property type="protein sequence ID" value="TBU10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1509p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="6623" checksum="32E4B2BF1EAFCC0D" modified="2019-07-31" version="1">MFGSKGVLVISYVCKGGVSYIGGSSSMFVKGVGSSSMFGSNGVLSIEGSVSYNSSVVKGYRILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQW0</accession>
    <name>A0A4Q9LQW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1536p0010</name>
        <name evidence="1" type="ORF">CWI38_1562p0010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001562">
        <property type="protein sequence ID" value="TBU10764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001536">
        <property type="protein sequence ID" value="TBU10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1536p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1562p0010"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="30465" checksum="31A63E916FAE9BDF" modified="2019-07-31" version="1" fragment="single">LVFRGKRVECDLSFRINDVRYGIIFEFIQKSNEFGEVLCDVEKRVDGFKDDFNINGNEIHNEDGLKPFNVNMFEERNANENNSSNLTLLEKLQNKSEYRIITKKITKNRNIYGRYEIINSIGPNDKDILFEIAREEILYDKDRNINNLSESESFLLREDGLEYLRGDFVVCGAWKSYRNLRLDISTIIELSLSDSSSKNLKIPLILCYKRILSGMVNGNFTAEKKCSVVYGLALKKISEIMNHNQFEDYFNGVWGLYTDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQY2</accession>
    <name>A0A4Q9LQY2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1476p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="PITK01001476">
        <property type="protein sequence ID" value="TBU10919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQY2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1476p0010"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="29062" checksum="D2C4B80D0542F6AC" modified="2019-07-31" version="1">MLYIIGLGLSDEKDISVRGLEIVRSCEKIYLENYTSLLKTNKEKLEELYGKEVEISTRNILEKTDLILEEAKDKDVALLVIGTPLFATTHTDIILRGKEKNVKIEIIHNSSIMNVMGCCGLFSYSFGRTVSIPYFTETWKPTSFYEKIYENFSNKLHTLCLLDLRVDEKEEKYMQPNIAIDQILESENILKLNFLNLDSEIFVVSRFGCPDQNIIFGKIRDILMMSHGNPLHSLIIPSKMEIIEKEHVTALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR68</accession>
    <name>A0A4Q9LR68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1444p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001444">
        <property type="protein sequence ID" value="TBU10988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1444p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7036" checksum="C228292CA118EEEE" modified="2019-07-31" version="1">MVDCGVFKIGFALKGCGFLNLKPKNNTPLISQGGTTLEEPTININEELDLEEETVLVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR95</accession>
    <name>A0A4Q9LR95_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1982p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001982">
        <property type="protein sequence ID" value="TBU10151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1982p0010"/>
    <dbReference type="OrthoDB" id="2191533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="28159" checksum="B68E4705BA2ACFE2" modified="2019-07-31" version="1" fragment="single">MSAENILAGNVLRLIIDNHSRDTCTSKKDIKHMFKISTNDLISTLNNIENKLNNICMKLVGIYKDFPTEDLNLAEKFFIVKNISDKFNENLQNNGESNKFTNKNENKIHTEDNNWNQNNSESNKFTNKNENKIHTENNNWNQNNKICDSNNNERNDNINNQYNKDFEMLVIILGVLYLEGGRCSYRRMVVVLKDTINFEKFISIFRKKGYLKVYKEDGEVMIEYGWRFHLEFPSFSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRK3</accession>
    <name>A0A4Q9LRK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0227p0020</name>
        <name evidence="5" type="ORF">CWI38_1356p0030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001356">
        <property type="protein sequence ID" value="TBU11149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000227">
        <property type="protein sequence ID" value="TBU18863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRK3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0227p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1356p0030"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="62"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="40988" checksum="2883481206B37054" modified="2019-07-31" version="1">MGIQDRIKEIENEMARTQRNKKTEHHFGVMKARLAKLKQDLLIPKSIISKTDTFEVMKDGDARVSLIGFPSVGKSTLLSKITSTESKAAEYEFTTLTCVAGKLNYNGTNIQILDLPGIICGASQGIGRGKQVIGVARTADLILIVLDPLRLSDKKVLENELYSMGIRLNKNKPDISLTITQSGGININFLIKQTNLTEPTVTGILKEYKINNCIMIVREDVTDDDIIDILTNRAVYVPCLFCYNKIDNLTLKELENLNLDENSFALSSQRDWNLEELKEEIWYRLGIKRVYTKRKGCFPDLDLPVILRKSCSVKDFCKNIHRDFVDNFKFALIWGASAKHNPQKVGLNHELCDEDVVRVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ2</accession>
    <name>A0A4Q9LRZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1751p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001751">
        <property type="protein sequence ID" value="TBU10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1751p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="17088" checksum="28FBF522CA9001FD" modified="2019-07-31" version="1" fragment="single">MYKMNIIDAENKTTRFGIVIVLGKLIYYLNIYTVSYIRFSIFAILFSKIHICRLNVKILEIDENKEFGSLQDYQDVHFLCMKTCTLLHSTQENRFKRYLTSYNSTSMFQFSYPNDIFLEFEFFNEKLIEKKEEVSIYIEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC2</accession>
    <name>A0A4Q9LSC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1211p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001211">
        <property type="protein sequence ID" value="TBU11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1211p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021033590" evidence="1">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="321" mass="38263" checksum="4918FE2A87D44597" modified="2019-07-31" version="1">MQIFLNLIPIFLICFEISHCASIVTSEFSNEAQINECTRDDRSADDVIFVCGIYKYEHKVTSVSQKLTGSRCNIKDLTSESKARKRKQPSEEDTQRKDKLSLDDVYARLDEHSRGNLAVYKLHINKIFENMKEDMNFSYFTFSFKCLFVEETTHFLFEKTIYFLISKEVILLKNICRFFQSRNDSIEKLPNSNLYYKEQLSEPKNETLYTELFERFDVFINIELKEIFSSSTEHGELKALKKNIIAFETQTFVKITNHYQLFYVPNQDFLYSDDFIGHWKNYILTLLEQKNHYIYLILPEVISFEIKLKEKLDYRIEFCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS3</accession>
    <name>A0A4Q9LSS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit 11 of integrator complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1647p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001647">
        <property type="protein sequence ID" value="TBU10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1647p0030"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10121" checksum="F63718CD1F4CF2A8" modified="2019-07-31" version="1" fragment="single">MQIIPLGAGQDVGRSCIIVYIEDKTIMFDCGMHMGYSDARRFPDFSYLSSTNSFDKAIDCLIISHFHLDHCGALPYFTEVLGYNGPIFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST0</accession>
    <name>A0A4Q9LST0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1641p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001641">
        <property type="protein sequence ID" value="TBU10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1641p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="323" mass="39318" checksum="FA2068F9A7EFB386" modified="2019-07-31" version="1" fragment="single">MFEKKSEDFNLCLKKLKRKKPFNFDSKEDDYNIKSIRSEDKYEKNNLENLHKNILERGFTGEYRKRNTSRNKNYNEIIRCTNWCSEKTIEIFPRLYYCSEEKQRNDNFGFFSRNNYNKTHESISLRSSKSKFNQRKTRINCDEDYYDAKRHEKVRWSDNFDDINCKVYICTNTGKSVILHNPNHRILEKYIFQQNFKYEIHKPIYIEFYKLSDIKILKSKIFKTFSYPNLNGWAYNYESEVLDFFNFLFQMEFFVRKYFQSRKSNVEEGIEINETRMDSSIITSEEGIKYTESIINLQNHEEISMEFCSFKRESDYSGSFNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSX5</accession>
    <name>A0A4Q9LSX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1310p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001310">
        <property type="protein sequence ID" value="TBU11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1310p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="773" mass="93700" checksum="359542E918961E8E" modified="2019-07-31" version="1">MKFNLFFHLISFLYKPIIFVFIYHSSERDIIFNVVNENDESSIAAINNELKPECLCLIKRDETNENDEKNCLERMFDRDENRQYEQYYIEFIERIGLKFDVFEKFNDTNSNIEIFICHHIRKSDFLTFYEFIITYYLPVHKMTIEKFYSILYFLEYFRIQYDNKLRNAVKNIWISLMESNEIKYLNIEKVSFHFSKQHYFSHALFKKISQEYLKLLNDGNDSEFSFFIREYKYYIFYTYKGLFTEDRKHTLVIDNKFHTGFYKRVVVDRRSRRLFFTFLNTLDIKYLHIYELKERYWKSFCFILQNLKKIIDEIVFFCGCISDDVIRSLNANLNFENLKKIVFIKSKFVTSFIFKEHLAKINEFTFYEVHNYGRYILDEIKEGDLNIAGNIIKSLKYKYQQYSLEESINKINYIPEENKDFYLKLLNENNFKGKFRIIEYFRFKNNNLEVECFYEYKGRFNNISITFYQLNGNQFFTTENTILEENIKCIEISFSEIKSDLLRDILNIKGLESLEINYSNIYIENEIFINESIKYFRFSYSNSDSFHIFYKLIGMIKGLQEIYVCKINCFTLNRSVDQIFYITELTHENTHEMIDLLNFLTANKKFAFTAENKDISDSENPKNTLKFLFHKYDLSSIKQLSIRHFFIDNLDVKAFSNLLNLKELNISRIDFQNISFSELFCESHEYKIKRMKLIQINISEKDFIFIANLKKIEKIICECCNIQKKTYGWIKFLFNSEGYITLKYNTRNDNLSNEVINFIKEKFKTKYIVIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT17</accession>
    <name>A0A4Q9LT17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1058p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001058">
        <property type="protein sequence ID" value="TBU11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1058p0010"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="15889" checksum="780B013DFA9BCA7D" modified="2019-07-31" version="1" fragment="single">SFQEKDKDLFLILNILKKIHKKFFFNCKKDVRKIVKKYRNKVFGGTNIHLCFNNLEFKNFIEILVEFYGGKCVDLRSANIVVGNNGLDYKWIFESIFCYRMVDYDKYKSDTVSNRKCSCNDWEEEIDKEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT69</accession>
    <name>A0A4Q9LT69_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1577p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001577">
        <property type="protein sequence ID" value="TBU10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT69"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1577p0020"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="304" mass="35617" checksum="6400896FF4C2836B" modified="2019-07-31" version="1">MVLNSPKMKEENLPESIKKTGVETYILSLRLDIINKRLKLVKTKNEKENQKKDNISKFAIKNTRNFSPFINATDQTIQSAHNTNPYNITYTPYNLLPISNKDTQSLLQEIYSNRRNKILSLLKIHNPTYRMPTEYKEGSRYSKLVYIPSMEYPNINFVGMMLGPKGSTFKAIETFCNVKMNIKGTYKEPNEIKPSTKRNLDTKNLNKKYIQPNKNGTKLADENVYNETDPLYCIVYGDTLHSVEIGVLVLENLIESAIDIPEMENNLKVEQLKELRSEKSTEKENVSEWEKYYIWWYYYNVYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT80</accession>
    <name>A0A4Q9LT80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1251p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001251">
        <property type="protein sequence ID" value="TBU11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1251p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020304174" evidence="1">
        <location>
            <begin position="24"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="564" mass="67220" checksum="0BE9D1B68A2BDC67" modified="2019-07-31" version="1">MFLSNLNLILFTFIVYNRYNCTTSNIQQSEDTREDLKQYFKDFIEKNDHSVKINEEYTNNNFIIKRYIFGRNLDIKDWLELEIKSDSYYYMICLEATDKLKAENTTLEVLKCLKYTYERFKIIENKKDFSINTDYTVNCLKDLSALGLSNKKSKIYEMMDIYILKSNSKEVLRNKSTMMIERLNKRNALQNWRLIFVSDHILEANTLLSLNQKIENFISTNNYPFKKQFLSFVTKKSKSVNMEETDYPRTSSLLSSVIPKHFISNEKFDKQNQKLKIQFEKKDHSEFKDFQKNKLSQYVVYQLTISDMVFDKSIEFLLLFKNEKIEYITSPKCNWILMHDTYYYKTNDFIMKTFKHNIESVIGNNLIDIFGKCINILKFCEAKIMFAEHETVFKEIRMLSAHNNEEVSNKFKNFFENVKKHFEKEELEMEICYKQFCEDTTKKLEAIPFEDFYGLNISSWDICGNSNYEYSKDFDCEFAELITNIGQDIVKIINENVFYNCISSQSNCGMLLRFSKKDEFAFELEFIFSFKDKILNMTIFSKEYDFDGNADNILGIFNTNWPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF0</accession>
    <name>A0A4Q9LTF0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1524p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001524">
        <property type="protein sequence ID" value="TBU10830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1524p0030"/>
    <dbReference type="OrthoDB" id="2190213at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="68050" checksum="037404DB6BF01A70" modified="2019-07-31" version="1">MFVSEELSSNVITKFKEILGCRKIDDLLLKIDGSKILDKKNKNKANREILHGILCDKSIYKYLNEYHRIINSDPRNFISVLEERHKDINIIEFQKVYLQKRLVLDSLEYEKLVIWLDKILNKTLGDKNIFEHKVNEILLNEENFLRYLMSLKIIQQRIIEDPNFVESEFSNINIDNFCILQRKLNKYLQKLIQSNNFSIYIPFMENIEDIKLKYLNYFYYYQNGMNIILEKLDSVKIKNLSSPKELHESFMKPIQHLFGYISFFKCLKKFCYISDQRYYIYLENCFKEIAEMANDKKKKLDEKEFYFKIRKRIENSDELNDSELGEYLLHNYAVFFYRKRRGKYLILYFEKGMVFVEIETDRLIFLETILYFCVQKCKLYDKNDEYNLKVVWRDTNESKELTVIPFISREAAVSVEEIINTTKDSKNKLEIKEEDSEARNYKSIPSAGKVEFKDKKIRTKYKESDSKSTILNFFASKIQFGDLNFIICQELFSDFDDFKKKSLSRIANYLYPEKNITENSINLAHYKNFKFYFKDGNELISIENQDDFFATRVFCKDKLYIFIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTF6</accession>
    <name>A0A4Q9LTF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1423p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001423">
        <property type="protein sequence ID" value="TBU11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1423p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24384" checksum="E501D237838C0AA1" modified="2019-07-31" version="1">MRFSKKQKFFLLAGLGTAVFCGIPIVISIFIGRKMRNQLLKEFNDFKELPLTKILKNQLKDNNDIGFPNFKFNGPDELVGEINNFGFLNADINDKSIKLSLSGDSLKDGEKNELDLFSKSTNISVKHKDTKEFFLFILHKANTFEKNNIYGSSHKRVLPDNGLREVIGNMLKNAIDSSEKLRDILSLFSNNIEELQQRLNQLLLRLETDKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTG3</accession>
    <name>A0A4Q9LTG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1494p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001494">
        <property type="protein sequence ID" value="TBU10885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1494p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="381"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="844" mass="96701" checksum="2B1BD0CBBCEF344E" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKMKAANEADEVKKWDSGIQKCELHLPAISLPSSSYTTITYPPLSQTCSKMQNSGLDTLPSPNTPLPSSVEVSACEPSYDMTNLPYNEKFGCTETLEVLKKLAQSEMGKKVKSEENEERRRMASCLADTCTLTDTKEYINLRDKFLMVVRTRKLPSKLIKTKFLDLINRIIDNPAAQVCYDEATRKEKPRSAWKENIESKISKLQEKLSTSETKSLKKIMQDVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDTIIIRPRFLYDEFVNIINWHPNWKATGIDGIYNLFIKKLTTLHKYLYDIVKVICLEGTPQADWFYCGIPQRGSDYRPITCMSNLYKLTTKCVTKVVQLEVERRGLLAENQLGAVGGVQRAKDQALLNIALNKEYGNNLKATWIDVIISKRKIEISVGLEKIMSKKIDRGILQGDSLSPLLLVLCMDPLSRKLNKINKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAITDEAKEFYKKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPARSSFEEVQSKLISRVERLCHTRLNAKKLFSAINQHAISLINYNIGVLRLEPADFSKLVDAVREVLVKNKIHLRPGCKERLYLPRTELGRGQHSVELRSEHMLLQLLDFLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYKLAEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM9</accession>
    <name>A0A4Q9LUM9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0544p0030</name>
        <name evidence="12" type="ORF">CWI38_0790p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000544">
        <property type="protein sequence ID" value="TBU02147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000790">
        <property type="protein sequence ID" value="TBU12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0544p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0790p0030"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU02147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="453" mass="51713" checksum="94ED3F34511B3765" modified="2019-07-31" version="1">MIEYFCVYTKKGILRYQKGEKPGYLDEIILRVGISPIQKTLSVRGKNITVESRGSDFFLIIDSKQTFDSFEILIEKFYCNFEDFDKNFDEIIKSLYYERSKEDKQSSLNKIKQSKVRRWSEENLDAAILDYSSEKSIPTYSESKLNTITKKFDFPRKFSLFSKKIKIEELKEKLSTHLVDKNVSLEISQKIVKNVYTELKQDGLEYVDQHVFKEKIGKILSNMISQINHEELLENIRKCNQKGKIFSICFVGVNGVGKSTSLAKICCWLLQNNFKVYIAACDTFRAGAIEQLKVHVQRFKSAGYEVGLYEKGYNKSDATVAKNAIIMAKSENYDVILIDTAGRMHNKKELMISLSKLIKTNNPEHLIFVGEALVGSDSLEHLREFNRAVGEGITDKRLDSILLTKMDTVDDKIGQIVNMTVAGNCPILFLGTGQTNMDLTKIDIKTVVDSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR6</accession>
    <name>A0A4Q9LUR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative scavenger mRNA decapping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1263p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001263">
        <property type="protein sequence ID" value="TBU11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1263p0030"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="350" mass="41138" checksum="2C541B25550477BE" modified="2019-07-31" version="1">MEASHTEKFKNFEMSQILTNTPNYISILGRIEDDQAIILASKTNFKVENLLNSLKTFSKSKLILQNDIFLSLNVQMPEEINIKLIHPASESDIKKYSTKEIVFTHETPQMYVEDKLIKDESENNWLFNIIKLEKENQKNKKDELGNKVTEPISEPKNDTENKINAHEEYDYETEKSDTIVYRQEDSDDSDKRIKKAKMMECESNKESKEPEKELKEDIIASTDEFIILPDIKWNQISTENLYLLLIFKDTSLKTIREVTDPNILKRAKIFVIEVLEEKYQLKEQNVLMFFHYRPAYYILHLHIVNIKCPVSLSSCIGRAVLLDDIIDNLENDNNYYKNKTFHFLNFTNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU7</accession>
    <name>A0A4Q9LUU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0887p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000887">
        <property type="protein sequence ID" value="TBU12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0887p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020306668" evidence="2">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="394" mass="40626" checksum="6F602C47C74077AB" modified="2019-07-31" version="1">MLFVICFMFLKIGSARSRYKSGGYSYKNAAPAMRRSSSYRSAPIQFNDQMQNNQFGQLNGGYSGNAMNGGKVAMRGSGGAIGGGGGAIGGGGGAIGGSGGAIGGGGVVINGGGEAMSVGGGEMGGGGGAMSVGGGEMGGSGGAMSGNGGAMSGNGGAMNKGGNRINYGRGALGDGNSARRNEKYRNSDFLNFGNAEEANRFYREMNKKFLSMYESQFPRKRSLGNRGGSLDNRKFDSPLNKKEIDVGGTSKNASAGSNELGSLNANNNTGVSGTTKKTQAENEKNESENSDAIASKPNDGSNNTLGGAKDAKQNSRDTELAIKDSNEAEIKDQKNKNKDGNIDLKNEKKQDGGLPGERNDTSNANVLKKQKETGLNDRDSTESNKNNPSDMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX3</accession>
    <name>A0A4Q9LUX3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-c protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0778p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000778">
        <property type="protein sequence ID" value="TBU12384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0778p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020604549" description="Fam-c protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13782" checksum="4E8545230F0343DC" modified="2019-07-31" version="1">MKLFFGFLIFFNFLVDNIFCAISKNDDNDALLAKTSSYVSRDEERVLFNETYSGKEQQKAAKSENPYIKEDITDSKKILGCCWSKKKKPSKTKNKYKELDQGSFQTYRRASSFDDIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV24</accession>
    <name>A0A4Q9LV24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mad3/BUB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0724p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000724">
        <property type="protein sequence ID" value="TBU12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0724p0010"/>
    <dbReference type="OrthoDB" id="2192347at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031522">
        <property type="entry name" value="Mad3_Bub1_I_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17014">
        <property type="entry name" value="Mad3_BUB1_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="38411" checksum="5D441F5CB2BCCCFB" modified="2019-07-31" version="1" fragment="single">MTTEMEKDEDILDKLAILDDESKDLLRYVEEVNISFNNCYEAVDGLLTASTLKQNLHIEFYKNNPSYIKLWQRYYEIKKDPKILFFMMHFGISKDYHWIYIELANHFKKLKYFELSYYVLSEAKRKNVFDAFEIEKEINNYSFDTKRFSDTEMKRILYPKRIYFWDTEWSINEILYCNLDNCFYKKNGEISFVSFEENRYLNGWWQKSENDLNFLEIKKFESEIENSYKYEEKDEKNFNKLRIETTDFENTKEELILQSKAVENQSNKNNSVVEQLNDSGKINKFLSEDEININNLIFQIKKRINNQKFIIFCLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA0</accession>
    <name>A0A4Q9LVA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0697p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000697">
        <property type="protein sequence ID" value="TBU12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0697p0030"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="372" mass="43407" checksum="5E27D76620424C37" modified="2019-07-31" version="1">MKIKQKELEKSLLKANKVFRRSIDQRIYGREHETRKIKEFIETGSGILNICGNPGSGKTFCVLKVLKNTNFLYVNCLVEENIIEEINKYKGLMVVIDEFDKFYMNKKGVCVGLLNKLKERMCKVITISNYLLFCDCSVVFKPYSYEDFVFILSKKIEDEIGEEIVEKGVVEVISRKHSHHGDIRKAFEFILKLINKKSKEVECHVINKKGRTCKSKKFNLIHKHKISPEINKKNKVNVDNKINTVNVENKKNNEIYIESEITTNNKINTESEITKNNKYNIENKINKENNIQDKYLNGESSLISICDVMESENKNEEIESNIHKEIIKELIENNYGCSKIEIYKKYLIKCNSLNIIFVDRNDFGLIYELLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVD0</accession>
    <name>A0A4Q9LVD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1054p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001054">
        <property type="protein sequence ID" value="TBU11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1054p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="316" mass="36784" checksum="93A4B2A1C3A2E605" modified="2019-07-31" version="1">MELEKSLIFSFVFGSLCFGYLIILQYIIKSNYNTFVFTHTLFVSIISFILNFIGRDRKVRIIQIIPIIFSILYGVLDYIIIICLCNTLSSKSYAYILIFIGIILFCLLLMTMKLTIMILPAFFLNYIFLQLFIKLEVFEATGTGFSLENIEFGLVKNDMSSYILAMIAGIFVRFMAVKKMRHHTSDRNYGVLSSFWMVVVSVICVLYKYGDFVDECKVVSKYPLSFIGCGILGALSHFLMATYGKMMDFHYILGFQAVFCIVGQLAFFAMKNYEFFMKTVVEKELSMIYLPFLCISISTLLFLYPHKMYYYWDDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN3</accession>
    <name>A0A4Q9LVN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0636p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000636">
        <property type="protein sequence ID" value="TBU12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0636p0020"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="283" mass="33318" checksum="51F0AB51A9A4A42E" modified="2019-07-31" version="1">MESIYIKKIFYLILLLILCLLSVIAIPLLCLLHFISKNLSMKISTILSYFLWRILGMILMCTMKIEYEIEDLEDVMNYENCIVVSNHIGAFDFLLINEVARKKKMLKNVKFIIKKSMKWVPIFGWGLICLNFVFVERNFLKDKLNILKWTKNVKKNKIPFWIVIYPEGSRFTDAVKNHSDKFCIENGIEPLKNVIYPKTKGFNLICNELRNYVDTIIDLTVEYSESGNKNVPTLSTVLFGRTNGTVRIKSKVCKIKDIENYDQFIVERFRRKDLIISKWKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW8</accession>
    <name>A0A4Q9LVW8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0603p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000603">
        <property type="protein sequence ID" value="TBU12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0603p0030"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="749" mass="86275" checksum="AAA8812D556F00E8" modified="2019-07-31" version="1">MFELFRGRFYRRLSELLESEHVVSRDKIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDQFVNIINWLSNWKAAGIDGSDYRPITCMSNLYKLTTKCVTKVVQLEVERRGLLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISRILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAEFHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINREKSATNDTCCEDTDTLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSALISRVERLFHTRLNAKNLFSAINQHAISLINYDIGVFRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHRVELRSEHMLLQLLDCLEKSKEISTRRVAILKVENTNKTHLALIKGFYNLEEAQLAKLYNEIEKRNYIQSYIMQEKMSLWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVLRCLHLLLLNRCKSHSVQEILDNEYAEKKNNITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEITPYVITWDGIVTKYHESHLKRLEMPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY7</accession>
    <name>A0A4Q9LVY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0631p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000631">
        <property type="protein sequence ID" value="TBU12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0631p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="16797" checksum="9A8C1C861EBC609D" modified="2019-07-31" version="1">MSFSFNEFSNWLKLHILTVLAPKRSACISLTSFVPKSSFPLICTWSTCKKKVSGLKGTLLEKYKKSPEIFYKTIVVWLITHKFNQMNDKPKSNLIATNDYIGGNEIIVEIEESKLVVCIWVLRLVEGTSARKIMLIPISGRTKEILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW34</accession>
    <name>A0A4Q9LW34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0118p0040</name>
        <name evidence="1" type="ORF">CWI38_0579p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000579">
        <property type="protein sequence ID" value="TBU12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0579p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8424" checksum="EC85A38DDD837440" modified="2019-07-31" version="1">MQDKGNTRIKTYIKIRNNRPDILILDKIETEKLRKYDLLANGFGLIFMFTVLCQNNISNTPKRLEIPDNLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW52</accession>
    <name>A0A4Q9LW52_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0100p0010</name>
        <name evidence="5" type="ORF">CWI38_0598p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
            <location evidence="1 3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000100">
        <property type="protein sequence ID" value="TBU04687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000598">
        <property type="protein sequence ID" value="TBU12874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW52"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0100p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0598p0030"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="244" mass="28452" checksum="D2EBEBA154E519DD" modified="2019-07-31" version="1">MKNSSTEQKTLIYCQTNSSDSFLKELVHLRSNTKTISISKKELHDHLEIQKIISKNKSSLFITGYKSKNNEEILKIGRLYNNEIIESLDCKILSNKKMKDINYHGPIPGVIYGIFFLGINDERLENLFSDIFCQKVKKINREYFNYNLIISKVENNKYVLKLVNINKNLDVIDVGPILEFEIINSFMCDDDVFSGFCDLFSRKKTKNIHKDSNKDKIGTLHIQKQDLKNLKIRKNYKRGKLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWA4</accession>
    <name>A0A4Q9LWA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0985p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000985">
        <property type="protein sequence ID" value="TBU11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0985p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="187" mass="21776" checksum="829520164411A811" modified="2019-07-31" version="1">MFQHCNQSIKTEDQVATKCEKMLDHDLSRRHNEVVRCIHLLLLNKYKFKVDTRIKTYPIYLLDKKQNKITLIEVGITSQDSHKIYGLVANELGLIYKCNVDIIPYTNVKRLQIPINVEAYIQSIQFILIDKEDLILERTSLSLILGVEEDGVKTENTRNILPLILDGITPEEEPTTNTNKIRTWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE4</accession>
    <name>A0A4Q9LWE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0694p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000694">
        <property type="protein sequence ID" value="TBU12616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0694p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020470768" evidence="1">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="514" mass="60242" checksum="3278167EF91DA7DC" modified="2019-07-31" version="1">MLHFKLKLLLWFLDFYDVTSVSIHIKNIDEDFYMQKLGTPYLNKEYLSTLKQVRSMNKTEFVPSLINLIHFGIQGLYCPATYQNSMIDLIGQNMRKVNKIFCGELNLPDIFQPMIRSFKLILPNLKELFLNGVNLDICIATELLESNIKHIEFHYCDFGIPDCNELLNFNSTGVFLPKKISITDCYLLPEVFEIVMNSKNIYCLVLKQIKNLPECFAHEFSLQPNLYESLRILKMYEINFSEKEFNFISNFTNLQKLDIKIPNNNNEPLSLDKFNLCSLSHSLVTLKVEGFENFTLKTIETLKYLQNLYIRDSTIMEFNLFGCFESKENLIHLDLFYTTIKDKQSLNLLSKCKNLAVLRLTHCLLKETEFGFLENANFRENITELYLKGNKINSLVLLKIFEYRKIELLSISLRETLQNVFSVFENCKFITTLKFLFIYDGILNEKDLKTIFSFTHLKYLILENCIIIEESSKVLNRLSDLPSLKIFKIADSTISCYDKNIIQSFYETVFSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN6</accession>
    <name>A0A4Q9LWN6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0037p0030</name>
        <name evidence="4" type="ORF">CWI38_0536p0040</name>
        <name evidence="3" type="ORF">CWI38_0908p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000037">
        <property type="protein sequence ID" value="TBU05210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000908">
        <property type="protein sequence ID" value="TBU12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000536">
        <property type="protein sequence ID" value="TBU13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0037p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0536p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0908p0020"/>
    <dbReference type="OrthoDB" id="2187509at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23511" checksum="66AE1D984A1E01EB" modified="2019-07-31" version="1">MERYSNFRDPFTGINPFLNPKRKSLRFFDYIIAVLKIPLLLFLPFFIDYFIKIKKKSEWKGEKCNVVCNNVSFLDKIILKKIFKNVDFLYYNDDINRKSSKLVKVIFPEECRSNGKALLRMKEVKCDYVCGLRYNDESVFLYGNFLYFILQFLASKNHVEIDIMKSVSSKDLAKATGLLPIDMGKKEFDDFLKILKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR1</accession>
    <name>A0A4Q9LWR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0526p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000526">
        <property type="protein sequence ID" value="TBU13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0526p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020289804" evidence="1">
        <location>
            <begin position="20"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="660" mass="77514" checksum="694B3D9FFD2424BB" modified="2019-07-31" version="1">MKISFSFPATFTFLLKVFATTNQRNNKRVLEPNSIAQNSDDYPGIDGFDYLSFAKVFLTQSDPIQPQEIETSTTEFLLNKQESFQANPQTSYLHEDYIPEENIEISSFDNASLHITCSDDNKTVSSIYSPTPLPAFHIAFPEKARKEQISEHFEEESMKRDVVNKQFNTETTCSQPIINDLSTLWSEEVSILNQEFQPANIPVEIQINRSIPYNVKVSEIINDAKFCFRNNEILVYEGIKNSISDEPSFNCFMNQIISERNLDKVNQESVQVIKQELHRIIFSSDSVDNCTENKYTDDGLDEENILFKLKDKNSEFYRNEYETYEDLKTILKFRRKLVKFENTFFPELATSEWAKTIEQNMCVNPLENIKKSKINLIFPELNLFFESFKANQFAYISKGHILYVHYLYEIMSLLTYSIFQNNESFLKNKSKDEISRSKILMNRRIFFMRILISELFISFEQDILKVQIYLLLNLLHYFSTLTLNRAVYFNTLLFKIKIRYIFRFIFDTNIKTGEDFKNSLLLGLIYQLKMPNASKLLQRGLFDLFLNNFCVPIYIDSILALINIYRDKFGKVSTDIVSVEGKEIKNLHQKINLLNFSQNTQTHDSRMLEIFLELECRISNLERRILRGSIQFMSFYAKRGYASVYKSILKQAELYYRVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT2</accession>
    <name>A0A4Q9LWT2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0812p0030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000812">
        <property type="protein sequence ID" value="TBU12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0812p0030"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="200"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="782" mass="88763" checksum="B998FFE1E976DBFC" modified="2019-07-31" version="1">MAKKKKNQENDFLGDLLKTAEETSDRSNIKEETGIMDKKTNVESKKENKPVCKTVDKETTKQENKSSINKNTIQYITQDNNQSAKQDIKKEDQLPVTRPTPLMGRGGKKGTSIAEIKRILDEKKKAEEEFQEMQRIEEERIKLENLKIKNEFKEKEILKKTEEKKVETKIKSTRRFAFKMKNKKEDFCKEESEITVSGNLKSPICCILGHVDTGKTKLLDKLRETNIQGAEAGGITQQIGATYFPLSSLLKKFDIEKTDLPGVLIIDTPGHESFSNLRSRGSSLCNLAILVVDILHLLEPQTLESIQLLKQRKTPFLVALNKIDRIYGWKPNEFSSFDETFKKQPKNAQIEFTERLNETIIKFSEISLNARLYSENPDRRKFISLIPTSAITGEGIPDLIRNIVQLSENFMVTKMKFKETLECTILEVKNVEGYGTTVDVILANGSLKEGDKICVCGFEGPIVTTIKALLVPQPLRELRLKSNYMTCKVVKASLGVKISALDLEKAVAGTRILFVEEDIEKVKTEVMQDLESVISNIKTSEIGVHVQTSTLGSLEALVSFLQSEEIPISSVSIGNVRKKDVIITSSILEKNKDFAVMLCFDVKIDKEIYELANSLQIKIFHADIIYHLLDQLKRHFITEKEKIKKENLLEIIYPVKLKILPNCVFNKRSPLILGVCVEQGILKIGTPVCVFKEEIIKLGNVTSIELNKKKVEEAKKGSEVAIKIEIGSDTPKMFGRHFVESDFLYSVLTRKSIDILKKHFKSEFDEEDVNLIVELKRRLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY6</accession>
    <name>A0A4Q9LWY6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0484p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000484">
        <property type="protein sequence ID" value="TBU13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0484p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10059" checksum="59EDED5B0C734717" modified="2019-07-31" version="1">MAENKEIRKMYENIRNEKRGFQARNMMVECTAGFLLTYPKKSEMDRNLLNNSDLIEDGETTVPETIDAIMDLKNNKALDKISSNPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX62</accession>
    <name>A0A4Q9LX62_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U3 small nucleolar RNA-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0755p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000755">
        <property type="protein sequence ID" value="TBU12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX62"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0755p0030"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="88787" checksum="D81559B770F4BBD2" modified="2019-07-31" version="1">MNEYSHSFSIPCKSDSKGLYYNNNKMYFTSNNSIFILDTSTWEYSHLISLPKQLKNLVINKLIFTSTEDRIYMIGKRGNVIGTLKINSSIFNISPSSKYLAVGNNNVLEIWKIPSEYNFTLFQLERRIVGHYDRITSINYINSDCVLTTSLDCTVRIFDLKKGKSVIIRKFRDPQISAYFDIDTLIFVGSRGKITFLREETTIKFILDILEGKNIFEEEIVECGSEENFKNDVIMYGSEIEINKQTDAIKFKKVKREIFKNKFNEPEFVDFTVENYNLRNKENRKVGISETLCIGKDVLDSSYLNGSLYISGKTKEEYFLVQIDDEFLEKKLETEYFEIYKLENFICLKGTSDLYFTGIKEFKLDFPDICSLDIYRNYVIVGSSDNKVRLYTNFKQFGQLEVNGCFGVHAAEKVIISVSLNGKVDALDYKLFKFRSFDLETKISKSAINEDGSILFLAEYETFNILVVDIKRSKIIETLSVHQGPITCMKFSNNFLFSLSLDNLLVQWNVFQGTYNSLEILGASNFCINNRMIAVSKHNEIQILDLQMNILKSIDFKENIEDISFSIDNSLILVRTNEFLRILHYKTHVCIQSIKLVIQDNIIPILLHYFDKKSFILALNDIKIYEIKSFEINPIELEIDTTFENLQKYLNDKNYFSSLSISLKMNNFELIQNILKTIPQKEVENIVKLLPRNLVIILRKNIKKIVKTDPFICLEWLKNCVVYHKGTCLEGSEVDILRVEIEKYLEDGYRNYYLDEFIKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI3</accession>
    <name>A0A4Q9LXI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative PI31 proteasome regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0437p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000437">
        <property type="protein sequence ID" value="TBU13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0437p0030"/>
    <dbReference type="OrthoDB" id="2196290at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="29794" checksum="B550FC0061545192" modified="2019-07-31" version="1">MDFDDFLKKVEKKFKVQEIEKDKFLITGNNRSYLLSRSETVDFDKFMEFFEKSLPLNQKEKPEDLNYEGLSFIKSKSENLETLSSNRYDFDFSPNKSFSRVGENDLYPTGFSPYGSFFGPNFYSPKGGMFVTEDDELFRSRVDKSKKDDEEPTPDVPPLARFDPFVPSKDKKAGANPDPDNLKKPGKKIAVALIAIIAIIVVIWLGVWAFKKGRSNKPDMNTGKDSNKTKSDSDKKAGDDTTDWNAKKVVSDGKKTVKSRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU0</accession>
    <name>A0A4Q9LXU0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0402p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000402">
        <property type="protein sequence ID" value="TBU13534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0402p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="20224" checksum="2CF1ED19FF7D792A" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXW4</accession>
    <name>A0A4Q9LXW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0392p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000392">
        <property type="protein sequence ID" value="TBU13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0392p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="750" mass="88210" checksum="C9A87981765CA287" modified="2019-07-31" version="1">MLIILLTFNRTVAQKTVAIHFYGNKESILKKNCLENSKSGIFQDTPDKNYQIFLAKLSTEYPKTFIVDLDTFYLKFSNEEEILDGQTYNIYINNSLLSYDEFTYFYNIVVSFPSFIDILNEYNYRLIFTIMNIFKFKHDKYFKRFIRLLWVSVVFNPIAMEKWYSKTSSRNEYEYSCCVSRIALVELLKLYRVSEETLSSIKTDNFDVLTLLGFQNDIIYINEDYLFINEFTLKEILAIHKKSKFFLKILDFFFEIHVFRSMVLFNIFYEKKHNDLFTLSLFRTCTDILLLSCAFTDDLIKKIYQVLKSKSLKTLSILYSDFLTKDQISFLKTLATERLNYIGKNEGSASYFSVSEFYLSICPIFSEIIDEMYKYEKNLNILPLDKQISFDDWRKKLDIKIHLAKTKIEEYKHLEAPFQAYISMELSSKFLTYSFTTVNLKEINQIQVYFMCANLTNFSLGEYEICRDIVSMKFTLTKIDNIFLSKILLFTSLKELRFFRATVLLPNKVTNIDNNTKIENIIFTNSSVDNQHNFVQFLNQMVGLRKLEISSPGKNSSPFVWSSGYLNLKLMNLTLLKYSDLSNLGVDLFSFPDFPVLEEFELAYKCTEGTIHNIFANRNFNFLQKLYFSGAKLGKKDEHSLEKFTDLLYLRFSCGCKFSDLKLSQLFNLNNTYKLKELAIYDIEIDYCDLVFISNLKSLENLTIERIASQIKVAIVAKAFISIKKIEIANIMISKSEIFEEFGTRLKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY12</accession>
    <name>A0A4Q9LY12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0330p0010</name>
        <name evidence="3" type="ORF">CWI38_0398p0010</name>
        <name evidence="2" type="ORF">CWI38_0625p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000330">
        <property type="protein sequence ID" value="TBU03231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000625">
        <property type="protein sequence ID" value="TBU12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000398">
        <property type="protein sequence ID" value="TBU13549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0330p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0398p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0625p0020"/>
    <dbReference type="OrthoDB" id="2200914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="191" mass="22926" checksum="30D8EC669D2F29D3" modified="2019-07-31" version="1">MDLENTNESVKNVLNIIFILTNNAEDLYLTEDNIPRVIPKQNIDLYQIMNKFIRLNKFENYLEFFESIETIKYGKFNSSLIFYKMKFLEQTFEEKFYDFKKIIESVKHFKKNKLKRKYFNKEIYDCIIRCNDFIGNGMIKDVYIGPFKLALIHKKYNNLKLFDKLMNEALGVAKMCDNSKGVEMCRKHLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP5</accession>
    <name>A0A4Q9LYP5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0288p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000288">
        <property type="protein sequence ID" value="TBU17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0288p0050"/>
    <dbReference type="OrthoDB" id="2195965at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="98944" checksum="6B28F96662390DC0" modified="2019-07-31" version="1" fragment="single">ENRKDNIKESKAENINENRTDNKNDNNQDLDKNINELENEGLDNTNDIFKNCYLLMDVEYFGGLVFDLDVHLFKGYILPVSGSVDNFKGKILLRLPSKNYNTRYEFSFLTDPSFKVSCKTGLGKEEDKLFLRGTLSSFMSKFMKYSLYRTFVYPSFHTQFIPQVIPSMKEVKYSSVEMNKDMKNKEIKELKNKIINDLRLYCSMDYKIMKYDHSIFYRRNGYFVNDTSNHLKCAHFILPEKVILEENKINDGNNGGGVNDKGSDLKGVSDKEGDSCNIKGVNISTSNIKGVNISTSNLSGVSNGSINNERKFYDGYSDVENKVMNSLYEFNIFKEIISGLVSCEEIHEFGKDISLVKMVFTGGNSYEFIRIVDKDCLFFQLNGLPEFMVFKIREKQLYVFYYSHTNDFCMNDNRIHKLKRRMYDKKMKTLGSVNLYKIMAFSRNKAKSYFLKKEDVKVEKKIEKIEFGLDFKNYENKFEEIVKMCMKSSDGNENMCVYRVDTKNTGLGDCIVGRVLVFDISEDMVLEGLESAEVRMKLLYNVMEIVNAKCFSDRMFVYTVECNGEKEKMYCFEDMDLKFEEEEVEFEKVEIKEKKVKKGTFRVFCDFMGGKLMIFVVEGNGEKCIVRFFSNENILLERSGEFIFGMKLRIRLKDFYKENFMICKSKNWERKEVVVRRGTYFMEIFVLEKGFSAFEVSVFDKKKRCVLLNGLRVLVEKKCRFILSFVEDTTVSIDIRNIYPERENFCMKFYDIANVYAHEWMVDCYAIFYGESTHQFEFASGCHLSFFWDIERNDSVSVNVYDETRSYQIKGTGSSIAPEGAVVVKYKNLSSKEKVFRICFGTVMIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ0</accession>
    <name>A0A4Q9LYQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0542p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000542">
        <property type="protein sequence ID" value="TBU13061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0542p0020"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00835">
        <property type="entry name" value="RanBD_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="165"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="33291" checksum="5B925FB4B176A926" modified="2019-07-31" version="1">MLPSDTDTRKIIQEKEDVEKEVDKNKEVVKNEESEKNEESEKNEESEKNQEVARNKNKEVEKEEKKLEKTEEKNEEKEEKKTKGEELKEQQTTKEQTTKEQTTTQIPITNTQSTTTEQTTTVQHKESPFLTSSVIKKKEIGVGSVTDEETEKIQQKFDEEHLKGEILFRGNCKLFRMNESKVVTRGVGKIYITKGESNGMVRIVMVRDKLMKLGCNHFIEPWSEILGHEIHENTWVWSTIGDTIDEISDKQQTYIVKFKEDKEAKGFKDSFEIGKENNRVVLESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV6</accession>
    <name>A0A4Q9LYV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory subunit Rpn2 of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0389p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000389">
        <property type="protein sequence ID" value="TBU13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0389p0030"/>
    <dbReference type="OrthoDB" id="2196194at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120638" checksum="87CF22F18499E506" modified="2019-07-31" version="1">MLKSLLLLDKIDSLPEEFVESHIHLFSQYTQPSEYSSPSLFSLHSFISKQYKNCSVLPLFHTLLYPHSDQKDLSYFIDENELSLKNSEIDLSSLLCYLVSTQQYKSLPVLLPYLAQHPIIPELIQKMPSLKMYRCLSETPNLPINILIDSYFYTKKDKIPQLLSLLYYQDKYMCFNAGLYLQETYPYFSNEIINNSTDLIINSDENKNLDESSVNKDNEILISILDGSFREKVILKFFLLNNKNDFSLLSALSRYKSMLTSSNIVSLSYVNAFINIKSTNDTFYRNNIEIFSSVKQMSKFVSIMCIGIIHKGNNSVYEVLKNMFPVAKGSGGSLMALGLVNCGFWRQEDITFITMYMEKGSTEEIVYGACVGLGLVCMGKKDKEVVEKLLLKIEGGLASEGAALGIGLVMLNEGICFKEDSFLNICENLKNKISKNFKNETLKNEDSESQISKNLKNENSESQISETSTSENNDSKNLKNETLKNQNSESQISKEENFILNTFNSLKDILINSEHERVARNSAVSISFMFCMSRDKYRKHINDMICSGNVIERMAGYLGLGTSYCGSEDSEVTGVLLKGMNDNDSGVRRVSVIGVGLVLCSDREKCFKFLQFYSGSHDTVVICSVGLVLGFLFCGSGDERVVRIAENMMKSSDGVVRQVGCICAGLVLMQCSGVCGEGGVYDKERYYKVVDRINILIMERSDDYSARFGGVLGRGLLECGSRNCFFSLFNSYGKITGERVVGFVLFMMYWYFYPYIGFLSLCVQPSGYFRVDEEGEWIDSVIYSEKVKRNDPVIKLPESKKSRKLKRRLGGIKEEVKVEEEEVAGYYVESGGRVCYNEKEDFGLEDWGIKIEKKKEEGSEKRMGKRMGRRKGLLRTNKGKIRPYDEAVFCYIQDRNIFWEAKGVYQHCNNISHSVQEILDNEPDIFILDKKKNKITRIEVGITSQDSLQIVETEKLRKYDLLANDFGLIYSCSFHLKRLEIPMNEEAYIQSMVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMYEELEEYGVKNSKKRKNTPLNSDGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD8</accession>
    <name>A0A4Q9LZD8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0336p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000336">
        <property type="protein sequence ID" value="TBU13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0336p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="17871" checksum="26EA57DBFDA80869" modified="2019-07-31" version="1">MAACNLEIDMLKNITLNKAEMKTRQEENEEIGDVVAQLENSSKLVDGKNHEELCNYPLSNNVNDAARILQAAQECYDEVTRKNIARFGWKENIEIICLEGTPQPNGIITGSGYRLITPDKKMCYAGVSDNQLGAHNLKEMWIEVIKTYNSIDPTYLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH5</accession>
    <name>A0A4Q9LZH5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0461p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000461">
        <property type="protein sequence ID" value="TBU13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZH5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0461p0010"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="20797" checksum="5FE811448533AFD2" modified="2019-07-31" version="1" fragment="single">MNSPIKMHKRNNIIRDGKSRVVKDFPKGYATSQQTKTEKIQNELPKPEVNAPSLPSEVEKDQKIFFSFDTSSYPPPLSTTDFFVTETKNTDPNLLRSSFYVIPAEPSIFQSINLPLTTVLQPFNSKALINEIENIKSVRCMECLAYVNIFTKIDDLGKYFKCNICNASVELKGIITKEDPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ0</accession>
    <name>A0A4Q9LZJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0210p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041738">
        <property type="entry name" value="GG_III-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="9530" checksum="FB978FB24FDC1EC9" modified="2019-07-31" version="1">MNFANLARFLQTVLLSAIVFRSNNKENKENKENKENKENKDDKGGFMNHIKEHKMWYIGGGAILILAIIGIVIYFMNRKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX2</accession>
    <name>A0A4Q9LZX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0457p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000457">
        <property type="protein sequence ID" value="TBU13360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0457p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="10803" checksum="66601D59527CFB16" modified="2019-07-31" version="1">MSEMKIKSAPGHTIRNDISLASLIRKTSLKNKIMPETLKVNFDIFTARLFGTYIIVNEISKIHSNWVSNVLKYSIHAKIISYFIVENKDFKADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZX6</accession>
    <name>A0A4Q9LZX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0187p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="118" mass="14330" checksum="E5B3C2AE92CB3EFB" modified="2019-07-31" version="1">MHEMKQTIQRIFREKIELNDLKKINTNLKNEKVKILIKQILLKETQNIRKILLKCRSVDEQEEFIKIIYKSIPGSIFERENNYFLSLTSHFLKINSRNFNNQSLEFLRILNFKNEIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M004</accession>
    <name>A0A4Q9M004_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0169p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000169">
        <property type="protein sequence ID" value="TBU19934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M004"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0169p0040"/>
    <dbReference type="OrthoDB" id="2190819at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="405" mass="47600" checksum="191CBDF69BA58E77" modified="2019-07-31" version="1" fragment="single">MSNFLRNPWIKNGFQFSLHYPARAQIIQILGNNENNTLKVLLSDSTNIVLAVLSKESLERFRETVATPYSEIKGCFITLEDYLYCYDSNTSQPYIFLKEFRYCGSESPIIGEPLDLIYDFDYKIAKEFKIFQPFSISDICIPKEEIKKQITPHNQQYLKEVFSEFYSDCNFLNENENIGCFSYNDGTEKEKNTNILTENISSRLNEIKEVNTSDSVHDSFSSSCPTDLIVDSVQSENLFTENEQTNSWLLFHQNSYPLQTCIKHFNKSTDNIENYKSKYFNRICNIEDKKDTKNIPEFEEYLIKYEENLFENDIVDGLETTFIDEEDKNSNFYRFEEKNKTKSKNNKNNSVTIVNSQSSINTSSSEKYFIRQATEKNIFMSSMKRKENKFQIKLNTKNSIFKQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0X9</accession>
    <name>A0A4Q9M0X9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin-like vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0096p0050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000096">
        <property type="protein sequence ID" value="TBU20289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0X9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0X9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0096p0050"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="37"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="557"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="643" mass="73282" checksum="AD0EAF798FE6A4D4" modified="2019-07-31" version="1">MYFCNKEERNMHTTMDLLIEKINELQDICTENGISHTLDLPQIVVIGSQSSGKTSVLENIVGKDFLPRGSGIVTRRPLILQLIYTKEADEEYAVFNHCPTKIFRSFEAVRQEITYETNRHIKAKNDVSHVPITLKLYSSKVLTLTLVDLPGLVKVPTGDQPKNICLKIEEMCKRFISNKNAIILAVTAANVDISNSDALHLARTVDSCYERTIGVLTKVDLMDPGTDIVDVLAGRILTLKLGFVPVVNRGQNDIERKKSIRLALEDEKIFFESHSSYRRNKQYCGTLYLVTKLNNVLHEHIKACLPGLQEKINVLLYENQLELSRMGCVNLSPKESILRIINDLNKKFTDVLKGNCDISSTEIYGGARLNYTFHSHFSKFISSLNAMESLKDESIRTLLYNSTGSSSLLLFSHTAFEKLTKTSISVLKPHSLKLISVIFNELVKIIHAVCQSVVGRFPSLNDKIISCLIGLLKKNSEHTHNLVSSFIDWNMNYISTRHPDFIKWNEVLTKEIERTEMFSFKDDNQVFKSKDKRITFDSPPNILKINSAISEQEMMEINIIKSLVVSYFEIIKKIVVDQIPKAIMCELVYKSEEKMQEILFSEIYECKGIEDLVTESDETSEKRKRLEKNIKALKQAYDLMCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M111</accession>
    <name>A0A4Q9M111_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain fatty acid CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0085p0040</name>
        <name evidence="4" type="ORF">CWI38_0297p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000297">
        <property type="protein sequence ID" value="TBU16399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000085">
        <property type="protein sequence ID" value="TBU20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M111"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M111"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0085p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0297p0010"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU16399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="620" mass="70952" checksum="AABFC5099EB17E0E" modified="2019-07-31" version="1">MAYQNKKEICEMVEKYGIFQHKNYIGDRYKTKEGFSTVLELMEYNSKKYPTKEFLGKIIENEIVWSTFETVYSEAKKISCFLKSFVPQKSIIGIYSINRPEWLITEQALYLANCINCPLYSTFGIESLKHILDETEMNICFCSGEKVQELFGNVLGNYGAKITHIISYDDLPDSFVKKMELSKIKLYFYNEILNNPNIIDVDVNRNFPKTEDIATICYTSGTTNKPKGVIQTHKNFISMITGYDVAVTTKTVFDINEESVYMSYLPLAHAMEHIFTFFMLYSRARIAFYRGNVKLLLEDINIIKPTFFVGVPRVFDVFKEKIEAKIAEKGFIVRWLFKKGLKSKILRAKKGIYTHRIFDTLIFNKIKMSFGGQFKGILSGSAPLNPDALDFFQAVFSCPVVEGFGQTEACAGNIIKSLNCFEESVVGVPFPVNQIKLDSTTVENNVFNDNRGEILIKGLNTTPGYFKIEDCSGLYTKDGWLRTGDIGKIENGYFKIIGRIKEIFKLSLGEYIVPEKVESLLKGGIIDDILITGNCMRNFVVALVVCKNELISDFEVMTKILNLANKKFKEGYLVKYEIPQKVFVIKNDFSFYGDFITPTGKKKRYLIETHFKSEISELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M132</accession>
    <name>A0A4Q9M132_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0089p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000089">
        <property type="protein sequence ID" value="TBU20325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M132"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0089p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="808" mass="97013" checksum="CA868E4BBDFFBB78" modified="2019-07-31" version="1">MIKLIRSIHPAKKYNEPFKKSKLITSFLGSLYVFFKLLQNVTNLIKIIVSTNFNICSVEVSFVEIENENVNLVPSSSNAECYFICVETCSLRKWDNHTQYQEFSDLSKKNKVLEIVYPNEIFLEFEFFDEQIIKKKKKVEIYIKEKNFYNFLCFIQHLKSRDTINKIKPGLFFEIIKYLNILRVQRDKKYTAFIKALIYNLIIQDEDYFVKKISNLSFNLQKCKNIYILDALKCFCRFYFLKKHFIYEVFDEYIPPEYSLQLFLHKKYKKAKNFTSMQFINFNLNMYFYRYLCRPKFREMWIFMMKILYVDKLSINFVFFRTEIDIHIILSSLPQNVQKITITNRDENIFIFDLLQKYMDLSHIKKLSISIIPFSNSLFEKMKYFKNLEQLTLEIREISMKEIIELETSEHLKRIKSIKLFFFETIDTFFEIECISLLGTENNIFIYLLDELKMDNNPQNMLENFIKYNFYNYLSGVNLILETSNYSYIDFAKILPSAKLKCLKLDIENVKDNKLENYDFLAAFKNLKFLFLTNIEITNELFIAILRQNQLISLAIDFFTIDTKLDCKIVDLINKSVVYMEFYNLSNYIGKCFLGFIAKFKNLKHLIFDLYISEYTGYVNSIFQEEFSTFEALIPTLYVDLPKLESLVYKNEFDSQYQAKFSVLHVISFFFNLEMINTLFYDVGYLYPDDLRIFENFKELDNLKLSIKKNDSNSNILQQILISNIKKTISTLKIVSNKYSWLEIISIYKFRKLKFLELGSMHIDDKDVKYYDLLFSMNLILCEKYTLKKIEGFNFTYFQKYNIKMYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M141</accession>
    <name>A0A4Q9M141_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0328p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000328">
        <property type="protein sequence ID" value="TBU14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M141"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0328p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11185" checksum="D5E197FC26D6C049" modified="2019-07-31" version="1">MDKDDVMQTLTAETVNTIDDDDSEEIMIEETEEYVSQGQNEMGNAYISLSKAHSEVEIALILEVILAHSLKESAAIEIYRRNKLRINYSKLIPRVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M189</accession>
    <name>A0A4Q9M189_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0067p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000067">
        <property type="protein sequence ID" value="TBU20460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M189"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0067p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13690" checksum="5A4202E37847D17C" modified="2019-07-31" version="1" fragment="single">LKEIKVYRINFQNMSFSELFCASKEYKIERMEFSKINISEKDLIFIANLKKIEDILFRSCDIQGKAYHWIKFLFYNKGYIELKYMFEADNLAAETIKFIEEKFNTNILLQSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C6</accession>
    <name>A0A4Q9M1C6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0304p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000304">
        <property type="protein sequence ID" value="TBU15966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0304p0020"/>
    <dbReference type="OrthoDB" id="7555401at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="38181" checksum="B7E085F45B1AA928" modified="2019-07-31" version="1">MKHKIRPLINKIHSFNSSKTPAHGILSSKPINTTTCTTRLNFIQPEETFTFQIRGNNGSTGPSLQLTKLNVYTDPQSFTHELLTSSHLAPQSKVDTSKKKRVDLPEETIPTAHATLLQIQEKECMYKIHQGTSDYSFPTNKIPDKRYKCTYHKSNNHTDQECIAQQERKRDIKRKDINHSKQSMMVIEKEYPVKNMEFIARINNTTFDNILVDTGASYSYVNSTFLKKTGILPIRLNNTKTISVANGETHQILEKVEFPLQFKLHPTITFKVDALVLPSMPTSVILGIDFLNKHNSEISFKEKYLTIRSVKLPLNLDAPSLNIGLDQMLIDKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M249</accession>
    <name>A0A4Q9M249_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0019p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M249"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="5723" checksum="ECEC5673005C919B" modified="2019-07-31" version="1">MNKCVADLYAEAVIGSTTGGTSGNPGIGGGTAGFENKEGSHEDKSLLFPISLAFFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M276</accession>
    <name>A0A4Q9M276_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0134p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M276"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0030"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6369" checksum="6D46F16AD3D6B854" modified="2019-07-31" version="1">MTVEMRLCSFTGRPIAYNDRSSVQITLAELDSEGKATGNTIFYDCCGSLLFKKVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M283</accession>
    <name>A0A4Q9M283_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0133p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000133">
        <property type="protein sequence ID" value="TBU20098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M283"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0133p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF3">
        <property type="entry name" value="OS09G0267800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="92484" checksum="AE528CEBED2EBF22" modified="2019-07-31" version="1">MFTNGKNNPNLNIKLVSILISILNFCILFDSSLAHKFTYSFKRNENFEILFFLEDTKEMNINTALDYKDSIKIFFDINYKFKNEKMHVYTYKKENFICFALFDNFLSPNSSENAFKTGIIECNFELSYFLRICNDIIEIPSKWTNYDFKSFLQILTSFKAIENKRLLEYLQVIIFNNLMQRKNSVSNNRDFELKEVFGSCFFSKIDISIKKLFIIAYLNVLMIESAIKDGNLILMNSVNDYVDSYLFNEHIPYGNILVNDFKIFCALETVLENAYMCDIFHVLLSQINIKSLIFDAYQGFEITDIKFKFNIVSSTVFKSIIISNFKNISLEFLNQLCMYIEEQIEFFTIKESTISQYTLDLFCKKKKLLGLKLNNVTSIENTYLIDEHIHLSSTLKYIDFNSIDISPTWWMNCFQKAKFCKIILTFCTVIAQKNFLDKLYRYKLYQSVLHFEIMFFKYEISSNFCNSLTYFLNLKTLKLRGYQTVYSTEIFLFKAIEGLKGLEFLDVQKFNFYLGSYNFLLRNHEIKVLRLTKNLLYSENRIVCSFNGLESLTELHLVKMNVSRSNLIEIFRIKNLEKLCIKSCTFETNTNENLLDFVSNNIKLLDFDGSRLENIKDINFLSKIKFIEYLNLPGHMLPPGYLSELSFHCNSSLKTLHYEFGTLNSKDLSRIEKLEMLEELNISESKFCESNFYRIGNDCKFFNSLKVLNLWFVEMHIEDLKYLKNFRRLIKLSLSMSGLDLIALQSSLNCISFRDFSTSTSTLAHNPEKIVNFLKEKAINLQVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C8</accession>
    <name>A0A4Q9M2C8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0222p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000222">
        <property type="protein sequence ID" value="TBU18896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2C8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0222p0040"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU18896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="373" mass="43833" checksum="455656EFEE27E5AE" modified="2019-07-31" version="1">MSVVSREEEYNILKDYITDFIKSGIGKSIYVSGVPGSGKTYTVTKLLKNIKQKNVFEYLYINCGHLKTKNSIYLNILRNTSCMKLNQKQGFLKTLQTHFLSCKKHHIMVLDEIDLLITPKQELLYNIFDLPYIESKNMSSKLLIIVIANTLNLPEKLFEAKVNSRLGTDRIYFKPYTHEKINKIIESKIILDKKIKSLDSKRKFEKNSIDLLSKRISAVSGDIRKVEHILDQINSETNQDIVKKSTKRLKSIKAKSELITIFDVDNTMKSMYNLLYYKYLENLNLYSKILLFCFQDSDILSKNILFEKFDLKFKILNLDRISYFEFLNLIDFLISIGILEEYCSKLRLKLLYPEIEIFYMNDKEFKKIKTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3E3</accession>
    <name>A0A4Q9M3E3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein S8e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_2301p0010</name>
        <name evidence="9" type="ORF">CWI38_0055p0010</name>
        <name evidence="8" type="ORF">CWI38_0176p0010</name>
        <name evidence="7" type="ORF">CWI38_1103p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002301">
        <property type="protein sequence ID" value="TBT97387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001103">
        <property type="protein sequence ID" value="TBU11640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000176">
        <property type="protein sequence ID" value="TBU19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3E3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3E3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2301p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0176p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1103p0010"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT97387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="252" mass="29082" checksum="9BF09E95D3627596" modified="2019-07-31" version="1">MGQNNFIEEFIKRHGRRLDYDSKNEKRIAREPHKISKLARKLHGHRAIMFHQSRRTQKIAIKKEICKKTKTVEPIETSAIPHFLLDRDIKESTNISKEKQKKSIKLRKYAVPIPKVKGISEAEVFSVMKSGKRRTNTYKRKVNKPCFVSDQFTRKPPKFERFIRPMALRFRKAHVTHPELKTTHTLPIIGIKQNPHSELFTSLGVLSKGSVIEVNVSELAMLSESGNIIWGKYAQITNHPENDGCVNAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M482</accession>
    <name>A0A4Q9M482_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0086p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M482"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M482"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0030"/>
    <dbReference type="OrthoDB" id="2189193at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="492" mass="56633" checksum="D451756CF104121E" modified="2019-07-31" version="1">MFLDNLCGLLTRNKNKSKNEISINKSQHKKIQNVDNKSKISKTEINKKPIIDIYGFKFNTNTKAFEVDKNENIDSKDKVSTGKKFKPKISQENRKDRGDDMCIIKGVQRTNSNFLSRVVGNEVQKEIIIRKLRSLGIFSNVEMQDGRIKVQELKRRINFGGKIVNENVNGTLKIELPNLLGKGENINFEIDSDKMFTLKGKKPIIFMSKVGKRDNFKKGANTLKIEAKKNEEENNENNKIWFTELSIYRKKNWIPGINFIFDGVSIGIQTEKTELILTGEKLNNKFGTLKDLSKGVIKFLKKYNLGKYNLKTNSEIGCFYFEEQIQNFFKNEIFATSKWKFRKYFLKFYSGIGNILGDIHESDKFWLGKNIKGYKDMAISPLENNMKIGGLSYVETGFKMGREIYGVDVFGFFNAGFCSKQRNIMETIKNMTRTYIYLPESTSMGLSWGVGMSTQLNSYKSIEMPRIEATLAFPLVKNSDIERLQIGVDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5A0</accession>
    <name>A0A4Q9M5A0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5A0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0050"/>
    <dbReference type="OrthoDB" id="2186070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20764" checksum="1502D470B536D2B2" modified="2019-07-31" version="1">MTATQILKTQNLKDIVIYNLLTNGIYNTNEIVNIIEINIYLRDIGYEAIYWYDKSCIILKNTLFNSDHTHENLKSNQIEEIKDIFKNILISDLSETNYKKYSMAKFLIQKRWIEIINGKAKMTKMCLIQNTEYLISITDKCTKCSLCDIIVLNRNTHEYCERIYKERICDNIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVR5</accession>
    <name>A0A4V2JVR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0049p0040</name>
        <name evidence="2" type="ORF">CWI38_0107p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000049">
        <property type="protein sequence ID" value="TBU05102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000107">
        <property type="protein sequence ID" value="TBU20239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0049p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0107p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="406" mass="48224" checksum="591B45A1011C5F31" modified="2019-07-31" version="1">MNIWKSIEIDMIEVKRLYIWIFQSYVLIYFNCASAQKFHYIFEKVENSEIRFYNEVHNDDIILEESIEDINLNIFYGSYSDLNGDLIHFFAYKTDNFIRFKVLDDILVLSASECSHGKIECSFNLLHLLELTKDISSLPDVINHYQIKCLLLIFNYFRVIDDKNIVHFLQGIFFKTFFYQNANEKNKILDLEEIFGFITIFKIDSYIKRNFISAYFKSLAIEHVFYEENLIFLSNKKEMIDFNLFNDHIPYKNLLINNCKILCNLENILTNRYILESFKILFKAIDIKSLIINNHHELITDIIDFHFFNQTLCIFKSIIFSNFSRSSEFVLYELSRAYSLNLKYFGLKNLSINIENLDIFTRKQELKGLLFNNVTFIGGIDRLQSFISSNEALDFVDFENVQTDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX62</accession>
    <name>A0A4V2JX62_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1675p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001675">
        <property type="protein sequence ID" value="TBU10572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX62"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1675p0010"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="33470" checksum="92BE931C8D4DE220" modified="2019-07-31" version="1" fragment="single">VNHGNEKQYFFALFCILYCYEIKKYEELEKIICDNLFDKKGENMCLLYFLNLIDFSFSDNIYEKENQNTEKENENVENTENNSKILIKIGEIKAEEICKLLYKDLRLNKMMRDIRVKKLRVISVLKKFYNLKLKIFDYVVKIVDPSKEDLGQLMTVLIECLTPDEAKKGVDMVLDKFCNLAKDDDMVVYGLNILKEISVRFDLDVISYLEDYKKSKSKAVGYAYKMLVKSYNEKKVVGNRSLLYVRKKASEANKENKKDSTEKKNKYKNFKKGNKRRKNNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX88</accession>
    <name>A0A4V2JX88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0762p0010</name>
        <name evidence="3" type="ORF">CWI38_1508p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000762">
        <property type="protein sequence ID" value="TBU01252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001508">
        <property type="protein sequence ID" value="TBU10862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0762p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1508p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="350" mass="40081" checksum="8A7D248ADD437DFF" modified="2019-07-31" version="1">MLFFSMVFIKLIISKDIEEKFLDKPLSLYTSSGSTKGLVRFPKSGIFFRDAEKIIGIGDKVHITKAAKNRYTITVFNSKICYFPSRKSIEPCKAELDEEDGWSIKKEKGFYMIKSKHNHKKPLKNRKCLKIDVSNKPRADLYKISAENCDKKDKDQLFSFKPHSTAMEDNEIESGSVEMSYKESNRESSSEMLETTFESQNEGLIEGIKEGLITTPIRITTCTTQTPDYSTQIPQNTYNYSNSYYSNYQQPNTYENRTQPSYNQQYGYNNTQPAQPSYNPYQQPSYNPYQQPPSTQYAPSNNICEPTKPFYSTVGATEPIYIHTDAYGNSYISGKIPVCSQNMSLLLVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX95</accession>
    <name>A0A4V2JX95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1465p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001465">
        <property type="protein sequence ID" value="TBU10942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1465p0020"/>
    <dbReference type="OrthoDB" id="2195444at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="511"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1164" mass="137575" checksum="00CDB9437E142E7A" modified="2019-07-31" version="1">MNYKNERIKIINLKTEFPTKNSPLKRKISLINRIKTLTQDSTIKDDIVEEQMGKFLSEITTALLSNNIKTFQDIFAIIEVLKHFLNQYLSTNQNLLNDFFNSLYQVLADKDNKDCLIQPSKDTFNFILYLEINFCEIYDKNFIKFVAKYFENTNLNIFLYLIYYISIQLNDKDFFKLENEKNKILKNFIIKKLESVNISDIKNCLEKSKWYKESLLNLGCVSTETMSAIEKETVPFHNDFLFYFKKYEKRNIESNTQEIMYKCLQKKEKLLEFFEKYLNSQIESVVGGKEKTFKIEENLKMRLEDETVLPQIEMLRISDNLITLLLSIRNLQIENILFSIFIKLGKIECFATILARSISFLPFFEPIKEKMFSVLESKNFLSKNIAIKYLSEFYMLNCINLNELLKTYEYLSDSGNIVLVLDSLKRINKFIFACREEESKLIFEKIQNIKNYSSGYQKAVINDGLADIFSKNYSVQTNINEFIIFIFNEINFEQIVSLFGISFGKNKNNNQRRNEKRFKDLKTELNKTKNNYKNDLSEVKDLKSELNKTKNNCKNELKDLKDLKSELNKTKNELSELKDLKSELNITKNNSKNNCKNELSELNKTKTSYNINSNNNYKNDPSESINFEIELNNEFKNISNCNTITDIKDISLSNPEFFKKCFLEIYKIFLDFPFLIVITLGKMYYFKNIDLLVEFCIILKIGEYILKIFYDLTISMLKTLEKQTLLCYTEFISKLMSRLEEDFKKNIKFDKNQTKKPKNNLKLQNVNLEENNLKLQNVNQNINLEENNLKLQNVNQNINFEENNLKLQKYFKDLKNINLEFKKNPNIFVNTVLETDCDLTDKIYILIIFLRNYNYKLDYKLFVLVNELVNYCEDVDLRDSGSDVSNENITNKSCSDMVDVRDFSLFEFLYDNKVGYTSSVIEKHISNSDICGTPIQFDYFFYKIIKNCLFLVVDEEISIDCVDLSGGGLLGFSICLLGFLAKHEELFLHIQNSVFWHDFYNLFDENTKENVFSMNLTTKFLEISSLDCSRQLRCIEITNFFIKKLNISQIRIFIVDCFNLPNLFRNSNREIVVMMYNLRHVESMEFFGIEECTTEIFFLKKFKNLKNLSLQFEDNSKERNFDFTLTSHLCDQLKYLKISNIKTFSYQNTVSFKNISHLEVTFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXA7</accession>
    <name>A0A4V2JXA7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1434p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001434">
        <property type="protein sequence ID" value="TBU11002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXA7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1434p0010"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="224" mass="25619" checksum="639B09C3474FFD77" modified="2019-07-31" version="1">MKLNIAYPTNGTQKLISVERKVEQRLYDQKIGNTFEGSILGPEYNGYVFEITGGDDRQGFPMRRGVPSSARVRLLLKKGDKGYRCRRDGCRRRKSVRGEIVSSEISVLSVIIVQKGDTEIAGVTDRVESCSHLPKRASKLRERFEIPEGADIKKFLVESITKAAKESGQEKVKIPRIRITGEWTQEKEDAKNAIKKEAEERKKRSKTQREEFFAKYPELQQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI5</accession>
    <name>A0A4V2JXI5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0965p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000965">
        <property type="protein sequence ID" value="TBU11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0965p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="52149" checksum="052308E63FBA2C5E" modified="2019-07-31" version="1">MCDVDVAMLSERLPHPPTFHDTTHQPPSSSCQTSPVCLVDTIPSSSGTDATAFGPANGMTNLNTDAILEGNRLMVMHSILDSVTVIEQEWPRSAILAVQKRFERIPGNGWPATLRYYNEKFSCTLDIDAFKKLAQNEAEREIRQEENGERRRIATCLTEPCTLTDTTEYNNLRDKFLSNIKEISEKGIGKVVVRTRKLPSELVDSKVLDLINRIIGEYADSYDNQAAQVCYDEATRKEKPISAWKESIENLHEKARKQEKLSTSETKSLKKIMRVFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVMCSDYRPITCMSNLYKLTTKCVTKVVQLKQALLNIAINKEYGSNLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL3</accession>
    <name>A0A4V2JXL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0834p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000834">
        <property type="protein sequence ID" value="TBU12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0834p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8751" checksum="B7BA505F02DB9F95" modified="2019-07-31" version="1">MNEIEIYPIELSVFFHHRNTRKNIYKIFWSNSKKQVKKDFKLQFKSTRSQESSAIEFLTLYFGRECANKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXP2</accession>
    <name>A0A4V2JXP2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit G of chromosome condensation condensin complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0712p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000712">
        <property type="protein sequence ID" value="TBU12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXP2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0712p0010"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="741" mass="87931" checksum="D340C49EBC675E01" modified="2019-07-31" version="1">MPLISENYKLEEIFNEIQQCNTTKYLQNLEKFKTFLNQEESFDENFINILNVILFSDKKEIPSKITTFIKKTIQEMSYNSKEKKFLINFCNYLKECIDSKYKNVRKNSIFLISLIQESISNQDVKIKIFEKDFIIKIAHHLFDKESSVRRETIKALESHQSEVVFEKTVIINVYKDIIRYDTSPDVRKEALKNINPIPTTFNAVFEKSYDINLGVRKMFYYNYLPKLSIKDLSLENRILLLKRAFLEREFDAKSIFIGKIRTEFDVSTNLLKIFELFFDTEERVLICLKELLEIFCGSTFFDFNDSFFKEISDFSSFFMVSYLEFKEKIQGRDSLNLPDLYTYAAFLYQKCQSFINKESTFESKNEFFIIQNLFKILYFYDCFTDESRKFLLSICYKILTTKATEEITENTILLCKLVCDSELEVFIGSIISKNIKNENTEMCLLVCKYTMKCIYPFLDIHHAIINEIVMPLFTETTNSSFKSVCLQIIFFFLIKEFKPEFFNILIENLNICENNIEIAVDLYCSNNIDKELIEKPVLEFLKENISNERIPFSLTRILLYNIIYQKTNLNEFDKYFLTNLMNIYYSTQNDKTKQWCLIFFNEYFSISCDILVSVLADVLGNLSNNHKVAMDQCMYWMRSTRYKVDFQDLFYNFLIYLIRNSSKSINYKIFINFLEKIPPNENWDKIKTKKIIYACSALRRKITECSNLGSLLNNLISIDDGEPMDIKYYDEVKADMNIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXR6</accession>
    <name>A0A4V2JXR6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0604p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000604">
        <property type="protein sequence ID" value="TBU12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXR6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0604p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10203" checksum="FCF8FD5E0C735DA1" modified="2019-07-31" version="1">MAENKEIRKMYENIRNEKRGFQARNMMVECTDRFLLTYPKKSEMDRNLLNNSDLIEDGETTVPETIDAIMDLKNNKALDKISSNPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU4</accession>
    <name>A0A4V2JXU4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0527p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000527">
        <property type="protein sequence ID" value="TBU13112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0527p0010"/>
    <dbReference type="OrthoDB" id="7789470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="902" mass="106400" checksum="A7B6ECE4200C8769" modified="2019-07-31" version="1">MSENYEILIYYKLYIMKCVDNIIRSFYCRKYRYVFKAFIPALFFVVTMFKECICFKIKIIFENEAEFSQVALHQNICFIDNSVQIKASNEAHMEYSQPENQNLLNCVEPIYEVIGNNNDTILDSKTHTHESKNSAKKKKLDALLSVCEEQINSLNNKSDDSSFQDENLFHKKAKRSNNPSSSKKQLRSKNQKNGINEGNSKDPTFIVFDYSDKYVIRSKYFDKYIGSEFTDLKFNIWEITKTNIDIKTFEIFLSVLYFGKYKKSLNLKIEKFMSFLEIFYDLFCYARSDVICSLYKNLIPVLIMYRNDLIDETLSEMPENISLRQKNLFLPFMNTFFDKVSAKFEINNDEFLVLKKTDQQNEVCFSHKEIIKDIKIRTTPETLMLLGRNFNSHTKLIPWILFILEINGIKISCDNMYYYEREEYEKEIQYGISNKILSNPKSKFLPSGILLTIKWLKIKKLKFLELERIKLRYEELAAIKQFINLESLILVKCILPEFCSLFAKLYSNFRKLKTLKIIGFVLTSTFFNNLKKMKIQYLDISCSIYKRNTYFLKPWNRDNQLNNLRLDYSHLGYDVIDNLMKSKNLKYLSMRNLNSSWFKKSSNYSLWPKRYEVLNLSGCIFHKNLLNFFSKDLQVDNILLEKLNILDLTKILKQKSLHLSTKKLDISKCALDLTAINFLKMFEILEILILRHLPQCELPLFAVDFFFKSHLISVDLSNSQYIQNEIIFLLQFGSLRIIKIPRCNLEVGFMKSIFTISQYSSVEHLDISENQLDTNDLYSLSLFTNLKYLVITLDSAVYIDYLTNHDKISHLELNTLILVKSYINQQIFQFIMEQPSVKHILFKYSTMIDNVIPVNLTYCMKYIKSIKFSDSLIFPGNLNTLVDLQKQGIIVDFCEKSLSFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY05</accession>
    <name>A0A4V2JY05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0319p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000319">
        <property type="protein sequence ID" value="TBU14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0319p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="10032" checksum="9E8BC37CAE858B52" modified="2019-07-31" version="1">MTKSKYLRHLKLLLPFLAVLYNKVDVFFNLNTKKLKFITNLQNRESFKWEMNFTDDSLIRITPEALNYMQQDDSNGKKEPLGAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY30</accession>
    <name>A0A4V2JY30_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0254p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000254">
        <property type="protein sequence ID" value="TBU18111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0254p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="550" mass="64428" checksum="7E113480DBA12388" modified="2019-07-31" version="1">MYFRKILFNDYYSLIIFLFLTCKSSNNSGHVNEVHRRVGNRAQRIRYDPQHARHNNLASKRYIRRYNPTGSGSQSFSCSGYINRNMPFQESSSQVFETKSGPRSINPPLLFSTNAPHQYSQMQFVNATSNLNSIHSVSALPNSSFFPPGRFNSTQNTLHMASGSNYNHNTINNLCFPPPFINPLPQTLFLKKLYDVIIKVLKYPTLGKFSDISIFFTSEYFFEDILTRSCLIGYFRTLKNLVAIEKEIININSEKKKEFEQAFLINMTKIDLEGANTNILFHVPMLITLKNFISKQLERNTSDKKYHVSIFFGLKLIESVIKKTHLAIYGTLNSPENIQLSFDPYRNNFIRTNSNIILEIIDWIFTLSFSFNETFKNAFVSIINVQKNKSLDVLNNPEGLFGIYDLSFLPDIFFLLEESEIKEIYEFNRLVLGYCNEDSRAENHGPIDLLRRNKFAIENERIIKMIGYYFIIFENFEIDFFKQRTSDNLVMNRYELLKEEFQEFKQKKMPLNPREILGLRKLFYATHFLFYDVIAILYNRNIYTTIIPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA0</accession>
    <name>A0A4V2JYA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0108p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000108">
        <property type="protein sequence ID" value="TBU20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0108p0040"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="696" mass="80114" checksum="59F4374B97801F9C" modified="2019-07-31" version="1">MVSQQYNTTPSYAYFLKTDTRQSRQREILLILDILTHLHHKHKLSTPSSKETYSPSLITSFMHINDSSLSYKLHLIKLAILDKKNLDKSIILKRLCSEKNHHNRLTFLFILALTSNRIDVVSLLLKASFPNNINQRILTPSSHFLPTFYHLAISINNTDLLLYLNTHHKPSNTTKHTTHNLTPLHFSSLNNTFGIILPSTNTPYTVITSMQFFLINMYLSPFNIEKRLTHRRYDSYVFDNYENTGHLYNPDNFPTPATCINSNLNFTRTKILGENDHKSETNIYMAESSSISQNVYDWYSTYNSISISSMGLPNLSKHLANWFSNPYHKYSSFTSSIPSFSLYPLDILCIRSNYISLSLFLKTEGAICAVSKICFMVHCDINITFLLIKYGGNCNQRIFGMTPLHIACMCGNRELACVYIAMGVDVNNVDDIGNTAMHYAAVRGNIGCVEYLIEMGGSITIRNKNGITVCDIMKCKCEHVSIIGNEIDEENGSKELSNEEKNKKSNEIDEKKIIDNKELSNEEKNKKSNEIDEKKIIDNKEFIEEEKNKKSNEIDEKKIIDNKEFIEEENDKIYINKKEKINNDNELKKEGNNRIYIDKEEDKNNIDECKGCYKKNDKEVYGIVDKILFRLKELKKGEKIASRIKQKECWVSELIKVEFESFIGNEECNNVFKKIVKGKLGKGLLYESTKRGCLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYD0</accession>
    <name>A0A4V2JYD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0051p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000051">
        <property type="protein sequence ID" value="TBU20563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYD0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0051p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="526" mass="62278" checksum="6A4694D22E496C99" modified="2019-07-31" version="1">MFFYIFLCKAALPQENDFRVILEDPTITNEIRMRILYNDIRADNKEAKKRISEILNKININKKEQLLKIASFYFNEIKDYIKEELHPFLIHFTTLICIIVYNDYNEKDFKAYQPELLFNMICFGKFLEMSKENEDIKKIVQDVFIKFVTNKVKISKNLLNLKMKEKEMKSVISKSFNKEDATDLIILRDIKIQFMEGLKSSTLGDFLSSATFEQLFVFFLYFKWRYFYNYIGSYSADTSYHNSRQMICIVNGDFLVGTIKQEIKSLSSDVNAEFTDQHYIEVFKFISEKFVAKVLKNPNGFDEIFDFEKNISNFQNKPEDPNFPLVFLQLLCEESDVIFIKTLYDFLKEKTTEQYHKYISAVLCLKALCLREATLIKNNIPRIIMEFLFLADVLKTESEKTEKIEIIKKLRKERIDSYKQIFDTKKIEYVKTQDGDYLDCHKVPKITILMEIYCFVELFSNDSFKTFLDKRINEKTKITAKDSKIKESYLKHIFEQEILTLPSEELKLLFCPSAPESPNTDSESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYG6</accession>
    <name>A0A4V2JYG6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI37_1806p0010</name>
        <name evidence="14" type="ORF">CWI38_0005p0090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FI-OER-3-3</strain>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001806">
        <property type="protein sequence ID" value="TBT98321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYG6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1806p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0090"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="205"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBT98321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="427" mass="47777" checksum="1A0C912B7D424B01" modified="2019-07-31" version="1">MGQNNSNISSKKDLDTTSLNLRRKKRVRDSKTTTKLPQVNPAIKCKLKHLKLMKMYEYLCMEDEILSLQEEKLEQNVQFSTEKLIVDQMRGSPMSVGTLEEFIDDNHAIVSTGMGPEYYVSIMSFVDKDALEPGCTVLLNYKDNSVVGVLEGETDPLVSVMKLEKAPTETYQDVGGLETQIQEIKESVELPLTNPEIFEEMGIKPPKGVILYGLPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKLVREIFKMADLHAPSIIFIDEIDAIGQKRYDSTSGAQREIQRTMLELLNQLDGFDKRNDIKVIMATNRIEVLDPALIRPGRIDRKIEFGLPDVATKRKIFRIHTSKMNLDPDVDLDILITSKDELSGADIKAICSEAGMFALRERRKDVRMCDLSKAKDKVLFSKQGGLPAGLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTL8</accession>
    <name>A0A4Q9KTL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2009p0020</name>
        <name evidence="3" type="ORF">CWI38_0735p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002009">
        <property type="protein sequence ID" value="TBT97904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000735">
        <property type="protein sequence ID" value="TBU12495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2009p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0735p0030"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="208" mass="25147" checksum="720E3CA30B36D242" modified="2019-07-31" version="1">MRCTVCKIETSGCLKEHYKSEFHQSNSQRKIHNIPPISYDEYIKSVEERAKEEKMREEKIREEKVREDRIKEELYNTESQQNNNNELEEVDSMMEQNSNMYKEVEEINELQIDENNIHEEYSSDKNDPLLVTDGINLYLPNGKVLGNREYMKYYKQNYSVVDTKERRKYEPIRVVGKLSRYIFYNRKESLKKALQINMLKKLRPFILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KU96</accession>
    <name>A0A4Q9KU96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAM72-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1878p0010</name>
        <name evidence="3" type="ORF">CWI38_1293p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001878">
        <property type="protein sequence ID" value="TBT98155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001293">
        <property type="protein sequence ID" value="TBU11266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KU96"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KU96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1878p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1293p0010"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="144" mass="16818" checksum="68FCE1AAACFBCC9B" modified="2019-07-31" version="1">MCEEEIDQERILKNKSVYVLHCSDCNAVLCKRGMRAMLLADINVQLFSTDRPLDTVQLASRDYFTLSCRCMIRDVACYMCGNIVGYHVSQPCKKCLNSRNNGHLWIFDMEKIAWRKRCSIQGSILRWNVLCPYEIENEDEIVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4Y5</accession>
    <name>A0A4Q9L4Y5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0443p0020</name>
        <name evidence="3" type="ORF">CWI38_0979p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000443">
        <property type="protein sequence ID" value="TBU02623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000979">
        <property type="protein sequence ID" value="TBU11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4Y5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0443p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0979p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="286" mass="34542" checksum="70169D86DC25F27F" modified="2019-07-31" version="1">MKKNKRLVVLVLLGIIQSIFGIFCIYIFLKYQSLEGFEKKIIGELRKFSKLEEPKSLSSLFDIADLYFIDMMKKRLVLLTTNNLNDNYSTNQNDLTKILFFGFFPEKCLFNDFYKIENDKLRMFILEKYLEYTKIPSDFSKTFLFDRLIFRGVFLNMNIFHYNRFAPRFLFKLCEKFRNKKYIFDKYLDFIEYSILANESNSKIDEFQNLKFINIVSNIENISLCLFLEKSIVFYFLKFELRDENRYFIKWEKNVIDYNFYSSNDIHSVAFLKLTFDLVTKLSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L555</accession>
    <name>A0A4Q9L555_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0446p0020</name>
        <name evidence="2" type="ORF">CWI38_1877p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000446">
        <property type="protein sequence ID" value="TBU02604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001877">
        <property type="protein sequence ID" value="TBU10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L555"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0446p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1877p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="103" mass="12543" checksum="62EFADCF4FC65925" modified="2019-07-31" version="1">MRKRISADGKYYSEHKDSDTAYDFLKSDSCINDVKTHFSSVFEARKKIKKNYIKFIEFERVNLPSFDFFYLRNLKKLECLIFVKCQYNDYHQFLNKLNLNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBE1</accession>
    <name>A0A4Q9LBE1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0045p0060</name>
        <name evidence="13" type="ORF">CWI38_0021p0080</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBE1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0080"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU05139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="307" mass="36036" checksum="E17D6C5E96D6A2B6" modified="2019-07-31" version="1">MDNFREVKQIGEGTYGKVFKGFYKDNKLPMAIKIISIEQDSGIHFTAYREIKILKSVNSNHIVKLEDVFIEEFYLFIVMEFLEFDLSGLLHAGYRFSDEQILSLSYQLLSGTKALHDLNLIHRDIKASNILMNKDGLLKLVDFGLTRSNDIIMTNRICTLWYRAPELLLGVTSYDNKIDSWSVACVIVEMKTGITLFKGYEEVSQLKLIFDMFGVPKEKFPWLEMFDTKKFKKNKPWYEIIDTAFSKMFNSDMLELLEEMFKMSPRERISVKNSLKLRVFHDFDSSIRIPINFKEIHDYDCKERKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC58</accession>
    <name>A0A4Q9LC58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type 1 light chain of dynein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0023p0070</name>
        <name evidence="3" type="ORF">CWI38_0084p0040</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000023">
        <property type="protein sequence ID" value="TBU05334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC58"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LC58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0023p0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0040"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="131" mass="15421" checksum="AABE5A363618231B" modified="2019-07-31" version="1">MAEKEQKTDKSNESTIKNKETSSDKENNKKEENENKEKPQSRIKVVKSLVSENILEFIENLAEKYKDTKKPTMIARNFKDELEKKFGKGWNVIIGGHYFGIVVYEDHFYVEIDIDDNRILLFKSYMPPKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCU0</accession>
    <name>A0A4Q9LCU0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2714p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002714">
        <property type="protein sequence ID" value="TBU05743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCU0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2714p0010"/>
    <dbReference type="OrthoDB" id="2192790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17136" checksum="5806C6D0E6C79AD6" modified="2019-07-31" version="1" fragment="single">MRSNICLNEKKKEFLKVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTLERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSEYDDAVRAVLVKNKIHIRPGSKNVCLHSVELRSEHMLLQLLDCLEKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE43</accession>
    <name>A0A4Q9LE43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5092 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0052p0060</name>
        <name evidence="3" type="ORF">CWI38_1131p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000052">
        <property type="protein sequence ID" value="TBU05080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001131">
        <property type="protein sequence ID" value="TBU11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0052p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1131p0030"/>
    <dbReference type="OrthoDB" id="2189917at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="212" mass="24904" checksum="2B8AF5737F4EC2AF" modified="2019-07-31" version="1">MVVILEKEGSKRCALEATNIEAFTQKTFLDLIKDSHNRKCDYYIARVRCLSKMESLKGAGFNVSGVYYCYDARQLCKYVFEMVISADGRRIRIKNFKDPIQQRTISELNFFRLRYETDTPLRAEYVGNHIDFLESNCFRSKLFYKEDPLDALTVNFNFKKNQKIPIFSKKQIFSLFITIIFILLLSTFLVIALEKDRHILNPIYALKSKLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG48</accession>
    <name>A0A4Q9LG48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2462p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002462">
        <property type="protein sequence ID" value="TBU07048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2462p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="16690" checksum="0A68B04D6FDC5BDD" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISFKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRYYNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG83</accession>
    <name>A0A4Q9LG83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2520p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002520">
        <property type="protein sequence ID" value="TBU06706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG83"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LG83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2520p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="4">
        <location>
            <begin position="94"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="4">
        <location>
            <begin position="499"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU06706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="733" mass="81408" checksum="C9FE7866BE561FB7" modified="2019-07-31" version="1" fragment="single">NSTNNLHPFSNIDRKQQGLSNSTNTLHPFSNIDSKQQGLSNSTNNLHPFSNIDRKQQGLSNSTNNLHPLNNSTNNYNPVSNSTNTLHPLNNNTNNNNTNTLFKYGPLVTAMRTGKAFLFDEINLTDDSVLERINSLLDDSNTLYIPETNETIYPNNNFILLATMNPGTDIGKKELSPALRSRFNEIYFDIPNNEIEGVMMDRVGYSVKGVSMRKVEIVSEFYNVVSVRSMLKGDSRVGVSDSSGGVSNKDSKLEGVSNKDSKLEGVNNKDSKLEGVSNTTNTYHPVSNTTNTYHLVNTNTNTYHPVNTPLQQYFNTLLLNLKGTVTIYNTNTFYSIKEESLELIGFKSNKKPILYENNRVFGVLPFLIEKYEKEGCYDMLEGKDNSSNNNTPLNNCTSNNTPLNNCTSNTYNNTLLNNSTDDNTLLNNSISNNTLLNNCISNNTLLNNSTDDNTLLNNSTDDNTLLNNSISNNTYFSFDNLTTLYNLRRILKGMFIRKPILLKGIPGVGKTDILKNISYKLKIPFMRINMSEQTEVEELFGTYVLTDKKLKYKLSSLSISLNNKLPSIILLDEINLTPSSVIEGVNSLLDYRREISVEGFKICNYNSFIFCSCNYEGEGRKSMPRSFIDRFVVIDMESYTEEDISKIMGCYNTSDINYSRGYNEGVNDSSSVGVNDSSSVGVNDSRSSVGVNDSSSVGVNDSSSVGVNDSRSSVGVNDSSSVGVNDSSSNRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGG6</accession>
    <name>A0A4Q9LGG6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDT1 Geminin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2464p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002464">
        <property type="protein sequence ID" value="TBU07037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2464p0010"/>
    <dbReference type="OrthoDB" id="2192570at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="77785" checksum="33E854669C9DFA57" modified="2019-07-31" version="1" fragment="single">DNEIDDNISRDNSLRDNVRDNEIDDNISRDNSLRDNVRDNEIDDNISRDNSLRDNVRDNEIDDNISRDNSLRDNVRDNQVDDIEINDNRWKNPIIFQDNKNIKTFISENNEEIKINKEKCFKNNDNIKNKPFYNQIYSNIILNNQDSVINKECKNTMNINQYNNNKIDKDQVLNNESQYKLKNENKMLEIFNSVDLETNSIKEQEMDEKQELSKIQELSKIYSSKENQELSKNQELIKKQELSKIQELSKKQDQDKIHELNKKQEESLKERRTKIQSLKEVPLLPCPIYTKLYLPEIFKKMIKLYNSLLTVYRFNKDKGLNTIFIKSLKSIEDMCNFKVSQSFIEQLYYISRECFIFRKVKIQHFSKYVDSFTFECLKDKNYFNQSVYKYYRNTYKNNEIIPRKSLFEKEIGKSIIFENKIEENIKDIKKEIDKSIIFENKTEVKEFIDFEKEIDKSIINSFNKIEENIKDIDQTDKSINNSFNKIEENIKLNSITQIENLKNKSKNIFLKIPDLSENKNLEKSENRNLEKSENKNLEKSENKNIKSENLEKKLLSQKTKDILERIQEKERKRRESFIKQCSDEDLLKEIKYKIDTYFSTTNKKSVPIEDIISVLCIFQGYSVLLKLCSKFQDIYFIKEIQGIEYLIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHH8</accession>
    <name>A0A4Q9LHH8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain hydrolytic ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2380p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002380">
        <property type="protein sequence ID" value="TBU07588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHH8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2380p0010"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="672"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="904" mass="101729" checksum="34E2A4A71359AAEA" modified="2019-07-31" version="1" fragment="single">YKGVSNNRYNYKGVVNESIDDYKGVSNDTNEQQGFNKSTNEQQGVNNNTYDYHPVNTNINNYHPVSNTYNNSLIDSLFVSLRNTLNTLESYLYIIRELKGIQSTLIELYSILKNNTLETENINKIIEVYNLIGVSDRNMLESVNNNMLEGVNNSSKQQGVNNRNMLEGINNNMLEGVNDSSMLEGVNNTSKQQGVNNSSKQQGVNNSSKQQGFNNSIYHYHPVNNNTYKQQGVNNTPSFNNPNTLPSIINTLYWCNESIKRLKQSMSCYLQECRENSPLLCFVSDIDILRGLSDIYNIIGVIIKVYEIEGVIYNEYEIKGCYYKEERLYFITPIKLRYNGSVEGVRDSGALEGVKELKCGIELEGVNDKDNDIKGVSEEYDIQQGVSNQYYIQQGVSNSSSNIKGVSEEYDIQQGVNNNTNPLNNNTNPVNNNTNPVNNNTNTLKNNLVRIINTFNYEITRLLINMFYNKNRDLHVIDELISEYSYFKGVNSNSKREMINYKISVINKYIKEKRGVINLYPRVYKGRSESIDKEGVSDRLESIDMSSNYKGVSNKNNIIDEGVSNKDNIIEGVRNKNGDYKGVSNKNNIIDEGVSNKDNIIEGVRDKDNIIEGVSNKSSNYKGVSNKNGDYKGVNNTTNTTHPFTNNNTTHPFTKSLTTTTYNTLYSFDTPYGFNYYPPPSLILTPLTITVLSYISLSLLQLQGVILYGPSGTGKTETVKYYSRLKGKRLITFCCNNTCSYDTLNNIFYGCYKTNSYVCFDEFNRLTKEVMSTVEDLILYYKGVKVFLTMNLGYKGRYELPRTLKGVLGIINVEGVSDSDMVGGVSDSGNVLKGDSDRDSVLECVNDSRNILEGVSDNTMLEGVSNSSMLVGVSNNNNEQQGVSHISTNIKGDSNKNNEQQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI51</accession>
    <name>A0A4Q9LI51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2527p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002527">
        <property type="protein sequence ID" value="TBU06670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2527p0010"/>
    <dbReference type="OrthoDB" id="6744471at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15864" checksum="8F765DA0D63CFE55" modified="2019-07-31" version="1" fragment="single">KKKKITLIEVGIISQDSFQIVKTEKLGNKNCSVEITLYEMTWNSIVNKYYKSHPKRLEIPMNIEAYIHSEGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKQARGTTLEEPTNNINEESDLEEETKLVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKG7</accession>
    <name>A0A4Q9LKG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2318p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002318">
        <property type="protein sequence ID" value="TBU08015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKG7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2318p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="573" mass="65309" checksum="DFDF810F6A7EF195" modified="2019-07-31" version="1" fragment="single">MNIFQKNKKLVLLLSTLAFLLGIVIGICIFSLHCANKSLKAFVDNLEKARKTAYYKKIYKELLESNSCCFDYNVKNDKTFYESGIYIPDNDLKRRLNGIIEKNTSANTNISEFTNISAFAERFHVDIGKLKNGIDNYGFFTKIAIISDLKNFKQKICYVDIKNEIKVLYSLLYVKKDDQLEHKITNHIEFKIEKSLSIYKIPDILTFLFYSYCASIVESPRTPLPTPKILTSTPRERFILQEPHLSTSRTNSRLSNEVNFDSVPQCLNSLSPMSENDPGAYQQNPSQPKSCLDQNALGLASEQIPQENPLSHEASKFLSLTNTHLPKLLEERQTYQEFQPRSHTHLSTAGQQNISEQGSTNQATNDLLLSEASKHSSLKNIEPELSINSGEQPTQNETESMIPENRPHQYKKKEPEMQHLGENAPSNTSPLYSHSISESLPTISKQEELETKEHLEQEKTPIQKETSQPVSKSDESESKSNISEEYSRVKPEEIPSIPQTQPEREFMSKTESPHTSQFSHHTQVSPPILSKQEELETKEHLEQEKTPIQKETSQPVSKSDESESKPNISEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLP1</accession>
    <name>A0A4Q9LLP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2176p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002176">
        <property type="protein sequence ID" value="TBU09174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLP1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2176p0030"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="295" mass="34684" checksum="458E41A9CFE3218F" modified="2019-07-31" version="1">MYFPEKQAFEMLTSIISNNNLHSLFDKTLSKLNLILEIQIYIFKKNIPNIYKHMSYNKIEPSLYIYGWYLTLFTRFPIQLVLRIWDIFLFYGFPILLVSASSILKEHEILILESQEEQLIEVVNKIEGLSFNVERVIKNLKVFLKQLDMSEIRRKLGVRYMLDIRISLLDIIIRFCNSSIISIMLDISNMYVIIGGVNNSIDYYKGVNNSIDYYKGVNNSIDYYKGVNYVYNTIRGVNNSIDYYKGVNYVYNTNTGVNHISNTNTVNISHYNTNNTKYPYNTKNTNISYYNTNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMD6</accession>
    <name>A0A4Q9LMD6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_2142p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002142">
        <property type="protein sequence ID" value="TBU09518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMD6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2142p0010"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU09518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="18986" checksum="7E4B162C8FBA90D8" modified="2019-07-31" version="1">MKLSVYDVQSITVLDEDGNIIIERNYSRTQCDVNTIYKKIISEKSDITIIEDMLVIYKIVNNIIIFICLDSEKNDIFAEKLLDVFYNSLNYIISGSVNKESIVSKYDLVLVLLNNFIDEGMVIETETDVLTSKIESRSFEELEGMQITGNVLSFLDSATKSLSSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN16</accession>
    <name>A0A4Q9LN16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2118p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002118">
        <property type="protein sequence ID" value="TBU09779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN16"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LN16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2118p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021028639" evidence="5">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="30838" checksum="16389077A21CB467" modified="2019-07-31" version="1" fragment="single">MNIINFCFLKRLYFLNLVCSSHISNTNKHKKISKEDFQNLGHEITTYYSYEDTIHSSPDRSLQILKAKNLITREYVLIKISKSKQYAAYLQKEKEFLDKFDHPNIFKYIRETKIGNTSCLVFPLAEDTLESLLKKQSLGNHYIRFILRQILNGLNHIHEKKMVNNNIRMDRILVKNLKYVQIIDFSKSCNTNESIKIFKSHDLNNIDKEFDYYSPEIKKNELLNEKSDMWSFGKLIKQLQEKNMSKPIYRTEDILSDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNU7</accession>
    <name>A0A4Q9LNU7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2032p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002032">
        <property type="protein sequence ID" value="TBU10088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNU7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2032p0010"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="22029" checksum="16A32BD1AF3FD7F8" modified="2019-07-31" version="1">MSHQQPPPNPGENYRPKKTLLDYLFDQANYEMEQIKESKRRRKETASRYLQNTPEPIRPRRPELPLPRPSYPKQPSPRKYKKRLSLDEPEAETSSNETINSFADIDDNKFKVLIHGDKKDYICPELDCQKSFPSLSRAKRHFIVHTGAKPFKCLNPQCSKSFSRKDNMLQHYRSHCSLTKDQYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPG6</accession>
    <name>A0A4Q9LPG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1924p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001924">
        <property type="protein sequence ID" value="TBU10234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPG6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1924p0010"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="31072" checksum="E04F58820B374608" modified="2019-07-31" version="1" fragment="single">MTATEEVTALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPKHQGVMVGMGQKDSYVGDEAQAKRGVLTLKYPIEHGIVDNWDDMEKIWHHTFYNELRVAPEEHPVLMTEAPLNPKANREKMTQIMFETFNSPCFYVSIQAVLSLYASGRTTGIVVDSGDGVTHTVPIYEGYSMPHAVLRIDLAGRDLTDYLTRILTERGYTFTTTAEKEIVRDIKEKVCYVAQDFDKEMSEYAVSKGADMNFELPDGQVMVIGSERFRAPEPLFKPSLTGIECSGIHETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPP6</accession>
    <name>A0A4Q9LPP6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diphosphoinositol-pentakisphosphate 1-kinase</fullName>
            <ecNumber evidence="3">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1848p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001848">
        <property type="protein sequence ID" value="TBU10324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPP6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1848p0010"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="45188" checksum="AE1B729611805022" modified="2019-07-31" version="1" fragment="single">LASINLFNENKNIDDTFNRLLDNVKFFSTSEDRVQESAMIFAKAFTRKGASVVIEETNPINLKENRNKFHENIKDKLKNDFEAFKSDEINEEICKTLDAFFEYKESKKLYMTSETKYLDKNEDSILNQSQESLSHLIFDNYLCNSEIYSEKKNSKSLSSSNSSSKESDSSLFDCLNLIENKYEYIFNDKEYLGNYFEKLIYKTKSKITTNNISELYELLKYLIIHKRKDLLQIFNQEKTEKLFSLVLKYHKFINMRKYGVNIEEIIKSSEFFCGNLINKIISNLNSTDGTYIYFTKENNIHALFNLISNILPNKNINFNLINFELDYLSYLSFLVYNDIIVISVNKGYVCDNIFEQSLDARHCLKMDNDEILGIISINDFISKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPQ6</accession>
    <name>A0A4Q9LPQ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1842p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001842">
        <property type="protein sequence ID" value="TBU10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPQ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1842p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="526"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134773" checksum="4848034653FAB211" modified="2019-07-31" version="1" fragment="single">MTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMCENDNVLKCLEETSGSNDENLSITTIPTLRKQKVSINDRERIIEKTLEGYSISAIASMYRINYQMVNSIVRRYLKTGLVFVDKRGGDRRSKLTLEKKESLQAYVDLECTKTLYELAEWVKCTFNIDVSTSTIDRALREFHYTLKRVTVVPELEVDNDDQNFVFLGEVGFAVVTRLSRCLNMRGESAYLSVTAARSRNILVVAAMNKYGMIYHKIHERAVNGEDFKLFLKEIHESCQRQRILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYCSFLYPIENVFSVWKNKVIRGGARTEPHLKEEFDNKLEANSSSNSSSNTSSNISSNSNNPTTISSINPTKQQNTISLFHTHSFNRFDTDFGLFTPTFPINITLTIYLLKTPYNSFKYTSFTGIKNLGGTCYINTLLQTLFHIPEYRNMILSLGYSNSSNMLDGSSSNNNSNMLDGSSRDKIYDKNKDKLINNNKDKLNNNKDKINNNNDKINNTTTTTPTPPTTTPLLYLQNLFYQLLTHTDIQIKPFIIKSNIFTDTNTHQDIHEYSKIFFDFLEREYKGSGGCGSNSSSSNSSSSNNIRDIRDIRDTNNNPNTTTDNNNPNTTNNNNPNTTNNTTTTNNNNPSNNNPNTTNTPTNNNNTPSTNPNSIIDGLLLNYIHCIDCNCKSTNKEHFQDLQVDIRDYNNNNISNTLNNSLKILFNKEILEGNNMYKCNIHGHVRAIKGMCLYKGPSVLFILIKRFNIDYETGEGYKINDYFEYPEVLEMVEGGGVGVGGGVGGLDGLDGSNNSMLDGSNKDIRDTRDNTTDNIRDNNTTTLTYNLHSVVVHSGTAHDGHYTAIINIKGNYYKFNDTIVTPVCKEEALECNYGGVHPYKNKVRVSNAYMLVYRRVGDNGLDNFIDNSSIRDIGSSNRDIRDKDIDTNPNPNKCINTNPNPNKCINTNPNPTINTNPTTITYPTTTPTIPLPIKYPIPTTTLHPLLLSTFKKEFKDKIIYIFFKPINIGIKGNIIIIRLKMEDDYREKVREIYGVYRKYLYMFEVSNSDSVVGDVGMYNDIDNNLVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQC4</accession>
    <name>A0A4Q9LQC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SacI phosphoinositide polyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1783p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001783">
        <property type="protein sequence ID" value="TBU10407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQC4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1783p0010"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="138"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="935" mass="108118" checksum="7EFCB1C850219E2F" modified="2019-07-31" version="1" fragment="single">MTAKIFINENKNEILLLNTVTDNLITISRIDESIKKGKSNEFEYDGCYLIYGIFGLIHLNGGSYIICIDKVSNKGEYFGKCVYEIKSILIFKLKNIKENISDSFEIKMIKNFFTLPGIFFCENDLFVGNNYGNESKNFLFNYNLMNNFIGVGEGCEEFVLKCIQGYFGSFNFNNLSVVLISRRSWKRVGSRYFSRGCDKKGFSSNFVETEQIFIKDKNVYSFTQVRGSIPLLWKHVVDIKYKPRYTVLGSWEVFKLSNQIFTEYYGNIYYLNLIHKQGYEKKIGDEFTKVLRKKKCNFCWTDFIKAGCLFNEDLTEIISREVEKCGYFSSVGKKQSGIIRTNCIDCLDRTNVAQYKIQQIISKKINQENKLWDESLENAIKNDFKRIWFENGNYLSHQYAGTASLKSWAIYNKKVGKIFDLIFTIKRYFLGRFYDGDIQNGYDLVTGNYKDMQRKELPLSFFLIFYTLVMLFSGPSETLKNNKIKTANEADELHPPANYLPSSLYTKTTHPPPNQTSSNMQNSGFGTILSPNTPHPSLPSYDMTNPYTLAIPQGNRLMILRTIFDSVTADQRNGLKLFFFFAVQIRFERMPRNGWTELHRYYNEKFGCTKTIKEIKSEENRERRRIATCIAEPCTLTDTTEYINLRDKFLSKIKDITEKEIEKVVVGTRKLPSELVDSKVLDLINRIIGDYADSCVPMTITVVARKIQAAQICSKVNIKSKVSRLVLSKDLFEKARKQEKISSAETNASRKSCGCVTDLSEALVKKNEFLNVYEKKNYDLIQNRFYRGLSERVESEHVVSRDEIVITYDDYLIPFVSDNHPTMFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYLYDIVKVIRLEETPQADWFYCGLTYLIPKGIPQRGSDYRLIVVCTTSTIVQILVERRGLLAENQLGAVRGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE1</accession>
    <name>A0A4Q9LQE1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1599p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001599">
        <property type="protein sequence ID" value="TBU10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1599p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18620" checksum="C98AD3CCB746A292" modified="2019-07-31" version="1" fragment="single">MEKRIERNNILDNGFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQU6</accession>
    <name>A0A4Q9LQU6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1509p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001509">
        <property type="protein sequence ID" value="TBU10858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1509p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21898" checksum="ED1E9DC32494C225" modified="2019-07-31" version="1" fragment="single">KTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCNVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPTPPLKQGKYKKYLLLILDGITTAKEPTTNTKEELELEEEIEVVEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR20</accession>
    <name>A0A4Q9LR20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2084p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002084">
        <property type="protein sequence ID" value="TBU09955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2084p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6609" checksum="29395C5F36F72759" modified="2019-07-31" version="1" fragment="single">YSQLQISRVCLPKGLFLTEELYKIIKSKNFYNEIYSDNISKYFKEIGIEAVLKCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRC1</accession>
    <name>A0A4Q9LRC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein Rad50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1397p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001397">
        <property type="protein sequence ID" value="TBU11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRC1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1397p0010"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="911" mass="109230" checksum="D51D7E6FB6AFD473" modified="2019-07-31" version="1">MKNKEEFLKKEEKFKEEIKKMDNFFNEKNNELIYNKNKLNTMQDKLNEIFEELFNEYKTVKSKYNRDSGVSNRLENKNIEQRFEEKNIEQRFEEKNIGQEFEEKNIEQRFEEKEAKLKYFKEIFSQFLIVSETFDENDCSLFEEQKIIAKELEEKQIILNEALKNLEKSFYYKNLNKKKLEIERNVDINCEYSKELVELNEKIKNNKNKLNFLLKEQERWNFREKQRSEKIKNINEQLLSIKYEINQLNIKLENKKDCFDVESIEEIQDLSKNLEECNNALAATENAHLIYKNFQKLGYKKSECPLCKKSMSVPEKNEFYKRLEIVITKIPETKNENELKREELMNKKNKLEIKNEIKKEKNQKLEIYKKLNKIYEKMINNLEEDDSIEEVDSSFLKEEESNNYNDMEFKHSEIPFYLNVLEKEMSEDDIKQRILEKNIKLKNEFEEIIYELKKEEPEVSIEKIQREYNQIKEKFDLNSRKIEIRNKNLEKFNFKSKIENLENQKNILSNSISILQKIIENTNIDALECERKNKIKIFEDEKQFYNEKLQKTNECIYKYKTLIDGNKNIKKEIEFILENLSKIEEEMEKNGFDSKNPYILKILKDEVGFRENLMKIKSNLVNLNNLLNRKKNNFKKAKIILEKRENKKKINLLNKKLKEFDFKELNSCKETLIKLQNLKNNFISEKNHILGELKQINSNLKMFKTELLTEYPETLKKYLKSYVECKTLDLILNDIEKSIKALDKSIVDFHSVKIAEVNQTLKNLWQDTYKGNDIDFIELRSESIGTKTYNYKIVMIKNGIELDMRGRCSAGQKVIASILIRLALADSFASHCGIMALDEPTTNLDKENIEALAFTLNQIIKERRNNNFQFVIITHDEEFVKMICKDDGCEYFYRLIRNSKGDSIIERHSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM5</accession>
    <name>A0A4Q9LRM5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit alpha of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1866p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001866">
        <property type="protein sequence ID" value="TBU10301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1866p0010"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="590" mass="66065" checksum="3BB32A2E8921B447" modified="2019-07-31" version="1" fragment="single">THFLNIKIFFPFFFKNFQIKYFIKPFHLKMTDISQHNLFIDGKVLVGNSVTEKFNNACTNTSNILRTSFGPLGLDKMCIDPSNNILITNDGATILTNTTNGNDFDIISQFLSNISNQQDKEIGDGTTSVTLLATSLYSKAVNLLSLNVSPRVIINGYRMALKESIRFIKQKLELPLQSSQLNNLIRTTISSKLINSAAEYFIPLIAKASKTLENYEVEEIPILKKEGKGINDSTLLQGYAINVTPIYNLNKFSQNSGNKKIILIDFNLKKTKLPLTTHIVIENPDELESIRMKEISQLKNKVMTLIKTGVDIIFSSKGIDDIGITLFREHEVMFVRRVRIEDLKVLSRLTKSPIYTDIIGIGDSEANQNISSDDFNNFTILPTTVNSVKQISAGENELMVVEPINNIMISYLLRGPNEAVLEEIHRNLLDSLHSVKSLTKRDRIVAGGGATELALSLFLQDFSSAISTKEFLPIHRFAEALLVIPKTLISNSGLNSTEILSKMVSKMQNSVKNKNESDIQKGNKQEQSNKYFGFDCLTGKIQNNIENGIIEPSSLKIKVLSIATEAVCNMINVDSIVILNKEKKRERNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT2</accession>
    <name>A0A4Q9LRT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1939p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001939">
        <property type="protein sequence ID" value="TBU10210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1939p0010"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="27646" checksum="83AB4E301387F5BC" modified="2019-07-31" version="1">MFLVFYQMIKEKEVEKSFQFIKDNLNCCFSLEKLNIKEIKGIFILGGDGTVLKILQKLNMSEIPDIYAVNHGFKGFLCPINPSEVEKMVLKINKNENEIKFLKRKRLFLKDGGYFLNDVIITRKACGKLNKFICETRCDSVIIATPTGSSGYNLSAGGSIVSNDCNVMIITFVCPPDTKIKSIVVPITSKIRVKLQKIPDAESVCIIDGGNEIVGKEEYEINNDNSFVRFAYLDENQSVLTELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV8</accession>
    <name>A0A4Q9LRV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1920p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001920">
        <property type="protein sequence ID" value="TBU10240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1920p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="788" mass="93097" checksum="D6A0DD9E691349AD" modified="2019-07-31" version="1">MLIKRILTATDVVRFKLLYDLIYVLFSAKIIGNVRSRNSTIRFQTNENFEILFFENKYEQNFSEYVSYGDYELKIITGSYEDLDDDTQPFFIYNNENFVDFELFNNILLYNKPENEYKIGIIKCNYDLSYYLRLTKDISIVSNLLNGYQFKCILIMLKHLKAVENQNLAKFLQALIPENLYDEIINVLMLKNHYLHIEEILSCDFFADVDLNIKRKLILGFLNKLMIKGDFYDGNLILYDKHNEDYDVSLLDNDIPQKNLLINSFKIFISLENILKDFCNHNILRIIFNDLNIKSLILNNFISDMIPSDDFAPIVLSIPSFTSITLSNVRLPTSPDLLCYTLRNINNNIEFLRLENTKTYGFNFMNIFNEKKLRGLVLRAVKLHEYTSFFDDWSNFYEKLEFIDFRSVFINSLWWKHFFQKANLNKIIVHFSDLNSEKSFLDEFVKITTSKINFFHLEIRFNYSELEINFLLSLIYFKYLRTLTLDGYRISNDNVMLLYQAIDSMKDLECLELCRYEDNTKPYDFLPDKLKLKSLNLQNIFLNNEIILILFFQSHRFITELSLKNVVLSSDCLKEIFKCENLIQLSLDISISNPDVYYESADFLSKNINRLSLRNPCYIFTQGFDMLSKLESLEFISISSCGSRTGYISMLNSKSALSLKTLSYRFSTLDSNDINKITGFKILKELNLFGCKFQNYTFLNFLNECEFFKSLKTLEFWVIGVKYDDFKGLKRFRKLKELSFKFSEFDLLKINNCLFSLPISQLHNLDSNNGKNHIVFSRYLSESNVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX1</accession>
    <name>A0A4Q9LRX1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1522p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001522">
        <property type="protein sequence ID" value="TBU10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1522p0010"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="32024" checksum="5D1027788DA9D95F" modified="2019-07-31" version="1">MNNVGVIYIIPDTNVFLSNLDILKNILKTKSKLKVCILVSSVILDELDNKKKRLVKAREAIRFIEILTKQKKLMIHNEFSEENINIQYTSETKYLEDQSNNLKGGNNDEKILAVALHYHRCVVLTNDKVLNLKAEKASINCILIGEMTNDEFILKFTNFFEKKPLEDTYLNLREIIEEKVKNLIMPLVLNLVYEKIGSAMKFYFPEDSEQINLSLLLDVIVKHFHLFSDFLPKFSFEKFKKIRNKHKLCSEIEFERYMKEILVLFRITDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS27</accession>
    <name>A0A4Q9LS27_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1249p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001249">
        <property type="protein sequence ID" value="TBU11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1249p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="154" mass="17704" checksum="867C771606B7307D" modified="2019-07-31" version="1" fragment="single">KLRKYDLLANGLGLIYKCSVEIIPYVMTWDGIVIKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPFISQGGTTLEELTNNINEESDLEEETKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS56</accession>
    <name>A0A4Q9LS56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1388p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001388">
        <property type="protein sequence ID" value="TBU11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1388p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="26737" checksum="3478D5F1507F3E3D" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSNSEVKKSKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVIVSACEPSYDMTSPRTLAILEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKELKSEENRERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS61</accession>
    <name>A0A4Q9LS61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAMK/CAMKL/CHK1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1801p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001801">
        <property type="protein sequence ID" value="TBU10385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS61"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1801p0010"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="16548" checksum="F35533770C16D38A" modified="2019-07-31" version="1" fragment="single">MQKYDIGETVSVGSTGIVKKTKNMNFAIKILTKTDKNKKDVMKEIKIHKSLDHKNIIKFIEDIEDETSYYLVMDLAKNELFDFIEPDIGMDLTLIHFYFKQLIAAITYLHNKGICHRDIKPENILLDNNGNLQLSDFGFSTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF1</accession>
    <name>A0A4Q9LSF1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1737p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001737">
        <property type="protein sequence ID" value="TBU10475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1737p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16083">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16083:SF83">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="93176" checksum="FEEFB9A0EF364D84" modified="2019-07-31" version="1">MNIYILLDRNFFFEVKRLCSFNFILYIFLLSRKFIVGNIFVYRFEIVEEAQLLFYNDVQKHKTNLSEIEEEYYLKTHYTIDSDSSIESKWAFTYTKDNYIGFEVLNNILDANRSEKINGKIECNFELIFFLKLTNNISLLPEKVNCYQLKCMLLTLKYLKALESKHIGTVLKGLLFKMYFGEQICFLKYKESFRQIFFAEIEYFIIKKLIQAFLNILMVNHTFHSQNLILLKNSNEIFDITLFNEHIPYNNLLVNDCKILYILEKAFKNLYIFKIFQILLHQLHIKSLIINNFLGNETNNKTYYFSIFSKEIFKSIIISNLYGSLNAILYQLDTAFDENLEFFSLKNINVDCYYLDFFLKKRNLKGLILNDISMDADLYNFQAFVHLIKTLEYVEFCNIKMSYTWWVDFVGASNIKRIILSFVSSFLADFFLKEFTKVISYSNVQYLEIWFSNSKLYLNFWNCLGYFRSLQTLKLINYISDMNIELNLFKVIHNMQKLENLTIEHDDYSDYFYNFLFKRHGLKVLNVRNFSSNRKIIKLNLLNNSKFLTQLILSYIKITESSLLEIFKLEFLKVLYLQFCQITLTKNSESHIAWPKNIISLYFKTYKPNLYNNIDILSGLDYLENLYLYGCKSLFGSLIDLSLMCNLNLKTLSYKSDTIYMKDLQRIKYLERLEELNLSKCRFFGVKFYDLGDDCKFINSLKMLKLFAIKICPKDLLYIRNFKNLNYIKLSNFGFTVILEKSSLISLTRSHIISKKRYEEFKDGNILRNFYNEIIGSHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF6</accession>
    <name>A0A4Q9LSF6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rcd1-like cell differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1190p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001190">
        <property type="protein sequence ID" value="TBU11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1190p0010"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20387" checksum="D3915C16EA01F1AB" modified="2019-07-31" version="1" fragment="single">MEQEDISTLCYKLITQKERTLLLRKICKILDTSPNNCQTFWKYQHVPLILLDEIVRTYYTLNTQKFTSEECSRICTVLNIMQRILYCKDIRNSMFETHMPFYLYPFLNLSDNTQKYECLRIASLGVIGSLLQDDSEVAVNYLKNTELIPLTLRIMDIGSEVSKVVATHIFLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI4</accession>
    <name>A0A4Q9LSI4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1153p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001153">
        <property type="protein sequence ID" value="TBU11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LSI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1153p0010"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1564"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1863" mass="222686" checksum="EDEB6D75A5C9AE5B" modified="2019-07-31" version="1">MKIPPINNINVIKAGLLFFTYDDSNEVFIETLCQIFSKFPFLSHKFTFFLEDLKDCHFLRDLTLDHSIISNTGLVQKQKFVYGILNLFKSFLYSDTAEVMHKKIHDKRNSKTFNINEIYQVLFLIHHKSENLTSFIITLENCHLKCFVESIIELLEVHLKRKKTCFIFYQSLEILDIFDITLFNNFRLLTSIIGIYFDSNKLDSALKVVDSLIVVFIFIVENETSFEQNLIDLLISTLLDVFIKYFAKITEAQYKIINNKITTLYFIKEISVSIFRLKNIEKYFKALRHFYKNNVVKKIHEFLESKDTIAIDYFFYQEFHIKQLLIFLNNILSKTNVHLYIDNHPLIENLIKFPEKLYFSENKLLIWDLAKHIICKVSYNSDNALFLKRLLLFVTDALNQHSLNKTSYSESNYIKLYEKLCLVVNFLSYINENIDIFYKISCMNIRKNIFRCNEFDQAAIFDRIFNLESKNIFKQNFHKVFYSNSDILTGFYEICYISLMGCILRFNLTNTLNEFKLYEVNCLFIISFGQNKLAFYLFNLSKKYFFIFASKYICDKLQPFERLCNKELLNCTQNNLQIKYVFDKIFLILEYFMISIDSLGDFSDGYKLLEFILNFLEKNLHTWAYESLINFFKNTISEFFHIMKILNNLEIFSRILDSIAQLDLNSVNPLKYSSIFLFVSNELNSYKPLERVFDFKSSEDKRISFYRIIASNINLNIDMNKKFAYNKEILFSFIEIYDSFDDEKIFSYLICLIRLSEYSGLFTKKEIYKNFGFKNALHFLSKDRRNIFSSQSILIEYAYLYLYCLFEDESILNYFDLKLVYKDDLRSPENRLLKNEEIYVKKYIFYDLLILLQSSKSFQETIITLKFLTESFYNFPLILNLIDLKILLDLFYKNTTYETEDDNFSIEKQQEWYINFKYGFYLLDYDNIEFFSMISFIHKVFLSEICCCKYSLNSNEEKVNLIDSNCEKNFLERRSQIFGRFLKKGLLDILVTAYEKFDLSQSCIMKIIGLITIIIDTREFILNNTCFVTKIFRIKSSMEHIVFIPKFLEKSNFTEIHMQKNGSVPILKSKKNIFKQIDYTKYLRLDFGYLKGKHSNSKILHDFAFNDKNLHIKEFNNDLEDLDSFKLLSKLFCVNLHGKMFDKTIKKIYPENSSTVRDEYDASDLENIYFNFLATYLQNISCEDGFKTHKLLNIGKEERFKFSDFLTEENLSNIFLRLLIFFKGGKEVYILNNIKSIIGVCSNHKLLESFNYFLIKNIEIYEKVQNDQIISYRLEILRLIVIDYQFIIRFKTDSLNFNVLIFVFIDITNEYFLKFDRKTHLRSLISIFLSENISNENSFVEFLLLNMNQINEKHLSLGFYFGLKTILFFVEMMKDKICKIFLPFDNDKENNLDFFVFKERLIDYFIKLSQEYLASIFIELFKDGVVAIEYIFKLYMDVLFKSSRLYFYVRKEVSEQDKFERLRNHLILKYLMAFIFNITYQTFYETINEDNDCIEVEDLDRELRKLYNFKLFENLLQNIFHYTDIETKKLILRNKFNRSEYYFRGINFKVTRSVIFNSTINILSQSNLMEIRYSMWFITFRYESGQGIGLIYDFFTLFGKEVNQNKYFEAFRTLDYYDISNLNNENENFIKKAYYFLGIIMAKCVAMNYVLGLELIDSFYLYSLKDKVTFEDLKYLDYEFYENINKCNLSDDIDSFGLYFTVNIDNLDNEYELKPNGSNISVTTSNLKEYLHFLFTLDELKLFIEGERAINIDEWMSSTNYIGDYHKDHHVIVWFWKFVKSSNEEIRKKILYFVTALEKLPIGGFQSQKFILKGFSIESTPCKELFPSSQTCVNLLILPCYDDEETLIKKFMIALENKEYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN7</accession>
    <name>A0A4Q9LSN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1140p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001140">
        <property type="protein sequence ID" value="TBU11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1140p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="621" mass="72915" checksum="C7195AC705DDDCC3" modified="2019-07-31" version="1">MKNFYDLYSYNFFNDLESYIPIPTDSFHEELQCTNCNQTSSTTDKNYSVSLCSDKYYFNDKIYSDAFRVCFCNYTPVKDSIFSENIAEFANSASNTSYPAQNHICNTLPIESYDYSLSLNHTELSSNQKNVSLQNSTIPNNCNISSIQSFSDSNKTYSSSVINHSEIRKRRLDNKISQQIKPKKRRNASDSSDEASSLSQDAASVISEVENISEENICTVETKSSFTEQARKTLTSLFSEIEDLNTESISFESMYSKKIYNYIFYYGWNKYINDHIENYNSIIINSVKEFKDVLDVAESLLFYEKYFPGYVSQYEIICLYEIMEGILLEIKNEENFGLFYELIKFVAYYESRLSEYIESNHCLHVYFILSIISNQLKNISFEILKGIKISKCNKNIKCTSFNDEIKEEYLKIFFIQRLFSKLLLGMKNGKLRTQFYIIFIILDFSSETHHKHHYLNQKSYFRFYLLVLASFILEYKFNSNIIVLNTFLKLSLNILNLKMNSQQLFFNETHFMMKTFFLGISTVKLNLEIIDKIKVFANKSSYISENLAYLREKYLNLNPDLSVSYKHLTLNDIFLSEICLSSFLSRQYEDLLFDNKIIPICWKRLYENKIKSPEYTLDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSU8</accession>
    <name>A0A4Q9LSU8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1152p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001152">
        <property type="protein sequence ID" value="TBU11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1152p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="19018" checksum="7342DB2A0B582CE3" modified="2019-07-31" version="1" fragment="single">KKNKITLIEEGITSQDSLQIDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNKNEESDLEEEKIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT93</accession>
    <name>A0A4Q9LT93_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1074p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001074">
        <property type="protein sequence ID" value="TBU11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1074p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020549264" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11779" checksum="A9D428E2E78EF5AA" modified="2019-07-31" version="1" fragment="single">MKVNFFWLVFGSKCLCAELTAMKQAYSQCIKSDKIKIGECINDIVHNSIIKQKEAYISCENKKYFVFYDIKQENSELLKDIITVINNQNTPFYCSSLKYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT95</accession>
    <name>A0A4Q9LT95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphoacetylglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1560p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001560">
        <property type="protein sequence ID" value="TBU10770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT95"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1560p0040"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="3">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="4">
        <location>
            <begin position="466"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="842" mass="97309" checksum="52105098BCCB39C4" modified="2019-07-31" version="1">MQSDKKSVQKIFENLPTFLKKTDKKYIYEPSGLRGNASDIIYAVCRTSIVAYIRSSTFCGKMIGIMITASHNPIEDNGIKICDHNGEFLDNSWEKICNEAINCSDTNLYPYLNRIHRKYGNMREFNNGPIGHILIGMDNRPSSITLFTHIAHTLQHFNCKVHNYKQVTTPQLFFLTKFSNQNGEPLHPSEYIKTLSRNYINLYNHLQTTPPLCYIDTANGVIQQNINLLKKEIPENILNIEIMNKECEETSDGYSKENSYEEDDVVIKDNVDERSGYRDKERSRESNEETSIESNKDSKNTINNDVNDTMNISIDKNINNGINNDVSNTINTQSEDLPTNLHLNNHCGSNYIKNTNKLPKNIKIDPHSIKRAVSFDGDADRLLLFWHDTTLNLITGDRIATLFLTYIHSLLYNTNNIDNNPSSDINTYNVDTNNRDTNNVDMRYNNPNNNHNPNINPIINNILNIPFTIGVILSHYSNYAAINFLKKKFPYKNITIKISPVGIKNFYKYASTFDIGIYFEPNGHGGIFFSSYIRSHLERVKKEIESKIELDNVSKIKVEKIEVDGVVFDVVDGDKSDLNNRDEVEYRVEYNKDNNKNNKDTGEYIKANKDTGEYIKANNEVEYRIECNKDKVEYIKDNNEVEYRIEYIDNKKDNSKDNIKDNNKDNNKDNNKDNIKGNNKDNNKNNIKDTNPITHHYNNIVTLLNIIPFFDTSISDAFSTFLSIHLICKNNYLSKILKKYQELFTREITVKVKNKNIIKVDLQNTVIQPILLQNKIEEYMYKYKGRSFIRPSQSEDFIRVYTESSSKIDTDVMCVCIAQCVYDTCEGIGYHPEITYSDSDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE4</accession>
    <name>A0A4Q9LTE4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1008p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001008">
        <property type="protein sequence ID" value="TBU11859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1008p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020409021" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36563" checksum="BFEAB77E681637ED" modified="2019-07-31" version="1">MLLKLRFFIFVLCSIVKADSMRKEIIGKHINIFTAKGDERRLVMADNMLGFSHLDAIVGDMDKVVFEKVKDNRYRITVNGRKMCYFNSRKNIEPCKSEKEEEDGWAVETGGDAFMIRSKYKSKVLGRPRKCLAIDMTKRFGKNSFSVKAAQCSAQDDNQLFLFRDYINPEDPPPQNTNDPDSSESSSSVKEDQPILTAMKEHGCATPSKVETTIVKRPNTPSPPPPQQTYSSSSAPIQQYSVPVQPINSTTYPTAYNTAYNYAYANSTPHQSLPSPTYNRSTSACSTNSLLPPSSSSQYYYVNSNSISNLAAPQTYTTNTLPTLLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU88</accession>
    <name>A0A4Q9LU88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1268p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001268">
        <property type="protein sequence ID" value="TBU11321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1268p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="52364" checksum="D5C495FD997C82D7" modified="2019-07-31" version="1">MIHYIIYLHIVLCSIQEIDEEIVNKPIDMDLNMICNEKKPKNFIRDINCEKPIDDTIQTSNSTCLASNDINPDLCSICEGICSNSRKYQKCLDKEECIVCNKIPRPCLKYLQSYVLSRKRSHSISKTRNKSKKVLIDVIDPDKIVCKESLDAIFGKYQLISGFLNGSPELKKILKEYPNMPITFEEIKLLNPTLLNSLIEIIKFSRTKNFQFVNYEAEMVYIHFNLDEISCEDLFTDIFLKILNFNIIEIEICKFKEILNEISHFLYNTKFPLKFWPEDKSHIKIKLEELFNSYNLKYFDLGIFRIRSLIFSIYINNSYLNTIPKRDREMYMLLILLEKCENEYIRLFHKDTLLNTQDNRLKIQNIKLDFKKKINEIMFRIVSCIQYNTNYYVSFDLLKVLFEDITNIIQIEKNNELKYANRIFNDFHLILFLLPDIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP4</accession>
    <name>A0A4Q9LUP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0779p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000779">
        <property type="protein sequence ID" value="TBU12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0779p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27961" checksum="57618A62E1576974" modified="2019-07-31" version="1">MAKKNQRNIIKTLKKISWDLLSTFVNMMLIYGIFIAPFLRDKQNFSAPAFPKHFILLFLFTMIRHMYNSRFSKEYIIIRQEFTCLLFTLFSTIIDEFLEKHPLNFDEKSNEIFFVIYPIFIILFRANILINLFKFKVKNDSKLEHLFYLFISVYAISVAETLFKPMIFTTTQLFSFRIFIYSIELILVPFISWYIALSQVTAFLIFYFSIIFTLDSKFLYWVTSNPYNLLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX7</accession>
    <name>A0A4Q9LUX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0745p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000745">
        <property type="protein sequence ID" value="TBU12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0745p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11548" checksum="2A7C0CF3EA5F6C0B" modified="2019-07-31" version="1">MLPNNKTSNLQIYLLTLLKEYKLYEMYILNDIKGVTLYLLYCEIVRCYLVREGVRRRIEVLYVIIGVIILCSVICIGIKGVIICKGVNKESKGVIICSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV31</accession>
    <name>A0A4Q9LV31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0722p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000722">
        <property type="protein sequence ID" value="TBU12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0722p0040"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14766" checksum="AEFC85289B2DE4C2" modified="2019-07-31" version="1">MNYGVILILNNIFDIRAIVSCNIYLKKYLYYGNNFDSDLKTLKFQTEKNSSDEETCTYNLRKRIKLETNKPVDYSKYQLFTLNDVESLAFVFNKLKKNGNSNIYEGDIILENIIYSDFDFFMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVG1</accession>
    <name>A0A4Q9LVG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0828p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000828">
        <property type="protein sequence ID" value="TBU12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0828p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10420" checksum="3B13E50496D690EF" modified="2019-07-31" version="1" fragment="single">MSQHCNQSRKKVDHLVTRCEKMLGHDYTRRHNELDRCIHLLLLNKYKLKSSKRIRGHTIRVDTRIKTDVKIRCNRPDIFILVKRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVH7</accession>
    <name>A0A4Q9LVH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1033p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001033">
        <property type="protein sequence ID" value="TBU11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVH7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1033p0010"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24061" checksum="C978473551D65D95" modified="2019-07-31" version="1">MNQITQEKLKPMIDEALKTTSSEEDTFEVQIALKGYDYNKDVRFDSNVVLPHPKRKNEKILIIADKTLEQKAVSLSLPFVNYESVQGASKERQKLKGKLCRRSHSLIAESTFNKAFEMRIINRKRKPLFIIKNVGDLQNFYNDVSKTVKFKLRKENTLSFPAGYAEMGSEKIVENVYLGLTHLLGLLKKGMRNIDSIFIKTAKGKPVKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK5</accession>
    <name>A0A4Q9LVK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit RPAC1 of DNA-directed RNA polymerases I and III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0648p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000648">
        <property type="protein sequence ID" value="TBU12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0648p0020"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="35202" checksum="75CF267E61395CFD" modified="2019-07-31" version="1">MYTNEGLVEEFENEKKTLNDVLNELEIEIIEKKDNIMIFDIKNVDCSIVNGIRRIIMSEIPTIAAEKIFMNQNTGVLPDETLAQRIGLIPLHFDPDLLDFVSNDVEEKNTLIFTLKIKNNQKEIKTVYSDDLVWIPKGEQKSTFKNNEPVFLKRVPITKLSCGQELDLEIYCQKNIGKVHAKWSPVSLASYRLMPKILLLDDFYDQEALKLQNCFSKGVIGIEEVDGRLKAFVQNPRLESMSREVLRHKEFDNRIYLGRVFQHYIFTIESIFIDPLSLLKKALLIFYQKCQHLKGEIDKCLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT2</accession>
    <name>A0A4Q9LVT2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3449 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0984p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000984">
        <property type="protein sequence ID" value="TBU11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0984p0010"/>
    <dbReference type="OrthoDB" id="2189371at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3A3" evidence="3">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor SF3a60 /Prp9 subunit C-terminal" evidence="2">
        <location>
            <begin position="299"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="49220" checksum="FD3B16CAF0634399" modified="2019-07-31" version="1">MKNIRNVYKILKLIEKASEIKFKYKNLEKKETLRQKDKIVNIYLIKILKKKFKKIKEKIYKSIKYCTIGEVNTVIYDFYEDIEWLKSKKEKIKIYNEIENKIRNKIENIFSKEERYGRCVDLKSIFEKYRSIMKFTEYKEFLEDFLCVEKYNFSYFSYLKELNEYLKSFCSRAKIRKNKKIENKKQENENESIENKKQEIELRDFFDSRTFCEGCNRIIMTKMVCFHIKSKRHMKNISCNLLNIKYEEIYKLEKEIKIFTKILKDEIELSKSLCNVIEIESISNEEISDTKKFAVEKNEEIPSWLKKYYGLDITFRCEICKNKKIRGRKEFFKHFKQPEHLENLETHNIEYCDLFYGITTFSGIENMKTRIFLDQNIFIEEVEDEEGNVYDKKTFEDLKKMGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW11</accession>
    <name>A0A4Q9LW11_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0749p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000749">
        <property type="protein sequence ID" value="TBU12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW11"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW11"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0749p0010"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="695" mass="76235" checksum="13EA6EE45567E692" modified="2019-07-31" version="1">MSGPNEQKVRTSGAVGIDLGTTYSCVAGYVNGELEVFPNPDGARITPSVVAFDDDDRRLIGTAAQYKLNLQASRVIYDCKRLIGRGFDDPKIAKAIKNWPFTVVRYDKEKKMEIDTVLDKSVVDNIRIKMKIGDQIRYYDPIEISSYILTYMKEAAKAKLGHEITTGVITVPAHFNNNQRDKTKVAAEIAGFTKLRLLNEPTAAAMAYGYGRSKGDKVSKGEETVLVFDLGGGTFDVSVLRFDAASENESGVAEVLATDGDTFLGGVDFDNALFDYAMSCFTRKHPNVDVKKITDKSKRRLRAACEKAKRALSSSTTATIDIEFFYEEICFTLDVTRSKFEDLCYPGFVRCMERVKGCLYGLGKGTALYDERTGVLEVKHDTAKVIEEQKQQIGKVILVGGSSRVPKVKQMLADFFGESKLCFSVHPDEAVALGAAYHAVMLADDVALKAEESILLLDTVPLTISIETAGGVATPLIPRKTTIPYKTSQVFTTYSDNQPGVTISIFEGERSCVKDNHLLGTFSLTDIPAAPRGVPQIEVTCEVDANGIFKVTAVEKSTNMTNSLTITNMKGRLSEEEVSKMVEEAKKYNDSDKEFKERMNSKNNLEHAIYSMKNVVKEGKMDESVKAEMLKKVQSYEDWLSANDNASKETFDAKLQEVQAMMGGAGMGMGGQPGPDMDMGGAEADKTGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI5</accession>
    <name>A0A4Q9LWI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-rRNA-processing protein Tsr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0913p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000913">
        <property type="protein sequence ID" value="TBU12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0913p0010"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="1">
        <location>
            <begin position="315"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="579" mass="68218" checksum="F0CD80DE06A47EAC" modified="2019-07-31" version="1">MTTKFGQKKTKEIKEFLEYPGFYKVVSFVALSNKIELDGIIVEMVERYFEKNKKFQQKYITDESFTNNNYSFNGDCISFSCRKNENYLFFNSNNFTDREATYISRCSDLIVFFIEKEIDNLDRFTMLMKNLPSFLFLYLNKENKYFIQKNVEKYIPKAKILYKDDFLAQLPTIKTFGTRICENRPYFVPKMFLYDNINQILEVEGYMNQGILSDKLICNGELEFIIEEYIIGDKRFSNSEIKNICSQNYNINILAETDDLEKHNLNIERQNIKENYNEEDLDIEESYESTITEEENSNKYELSETEASGSILEDKIDLIEKYSEYRGIKNLSTCNLISKEYPDYYENLIFLKNYKGFEKYSKNLESGFGNHQIVKMKLRKNSNIEFNFKSVVFFNILEYEDSLSIFNVSFESNNLIKDFDKLFFDFGYKIIEATPILTNNSSDKIHKKLFETKSGVMTFIAPLCFNVPKVLIMDSSNNILATSTVFWFGDRNIVEEVTLKGYSIKVNKKSVTVKRMFSSKNEVLYFRNIDIHTRNNMKGIIKKPIGTHGMFKAYFPKSFKGESTVFMSLYKQIFPKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM0</accession>
    <name>A0A4Q9LWM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0662p0040</name>
        <name evidence="3" type="ORF">CWI38_1099p0030</name>
        <name evidence="2" type="ORF">CWI38_1908p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001908">
        <property type="protein sequence ID" value="TBU10251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001099">
        <property type="protein sequence ID" value="TBU11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000662">
        <property type="protein sequence ID" value="TBU12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0662p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1099p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1908p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="8805" checksum="DC19591AF621F67E" modified="2019-07-31" version="1">MGVIMRAEMHDEPTPPLKQASREEDGAKNFKKQIIYTPYFRRRNHVREPKININEEPELEGETTVVKKVEEIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY5</accession>
    <name>A0A4Q9LWY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0603p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000603">
        <property type="protein sequence ID" value="TBU12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0603p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18812" checksum="B97CF93AAD3D3D54" modified="2019-07-31" version="1" fragment="single">MIFYYLISVFTTIINRKIILDYSIMDEINCNKNINTLNINNIGDAYLIYCGISKREYKYKKSEKNVWCEYCEGMKNIEENNVHFVMAIPNYVFEGSKFVFRFYSLVSTHISEYNVLICWGNSVKNLKYTSLKPNNSLKYDSIIVLNKPFIFVKKLRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ2</accession>
    <name>A0A4Q9LWZ2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0503p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000503">
        <property type="protein sequence ID" value="TBU13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0503p0010"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="41506" checksum="AE602BE12653D403" modified="2019-07-31" version="1">MTHWTSNRRLDRSSSLPIFFTNYSNERIEETIRSTTAKLINCETDLLRWDVCDLEEYPIEIRQLQRINRDRNIRISICCNSLKYISKYLISDSVVELSLQFNKISKIPQSICKMKKLKVLNLSNNIIKMIPAEILCMKLDVLFLENNCFFEGEIVQKLNEKEKMKIKFFKESENEKNIFGGEIVQKLNEKEKMKIKFFKESENEKNIFEGENMEGEGCNGSVENILESFKEEEVKNTESSIYLNSFLSSNNFRSKFDNKNTKSLENTCKDKLNVKDDIKEVYCSVCGNMTDYNLHFYENICREGINVTLEYVLCFHENHSFNQDETDANKRNVLLTGKISDNFGTNMGFRQDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX34</accession>
    <name>A0A4Q9LX34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0835p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000835">
        <property type="protein sequence ID" value="TBU12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0835p0020"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="39658" checksum="C36A2208090C7E68" modified="2019-07-31" version="1">MREFILNNESNDPSEVLVIKNESLNIHEKTPTMYESRKKFKKNKRMFLMKKEEKNVFQLEMEIRGSLSDNQLRPYKSIDDDILSHLHEKPILTDFSSKNIRVSISRTKNDSSKCTKKTMHNDPDAHANNNLFFIDDLKLQSIESSTLSTMKDALFKILLSSRRCCVYEFLGILEDINFVPLETTQKKSFDVTNQHVISLSYYHRGIFLLELINNKLHYRTGYKEWVYLSRTELKKTHTVLSKAQLAKLYNRIEKRKPPPIIIDSSRGPKKEKIWSRDEETRCKMLGQDYTRRHNKLDTLQRLISRFEIIESILLFCNKRKNKCTLKQVGITSQETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX96</accession>
    <name>A0A4Q9LX96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0471p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000471">
        <property type="protein sequence ID" value="TBU13314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0471p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45638" checksum="803D89C0814F2832" modified="2019-07-31" version="1">MTVKELKNIFLTKFPNYDLMMFKNIFFDKADSLIPVLDELKNEIARFVLNEISNDDSIMVNCLVKFFTETKGIAPVRLSSNSWKDDMNLGIVSSDYSGLLYKNLDKLISNNILKRKEKRVCKKKLYSKTDINEQRKTVLLNKFEIDWPSSMGHALIKLMVRFEEQLKYDRLLYLSFEASLLNHPGFLNRIKSNLLLAKTHIATLKSQNHRYMKQDTKKYNSQAVESNRDLTSEELNRRFLTGIQNYDLIHLKKIYYMNEVFPINIFNQLKNKITEFVLSKISKDDSIIVNCFADAFSNTESLIPYGINCGSNGYLSISKLISNDYGEELYRILEAQILQNILNWYESKEFRNLFYDVLRFSIRYLKIDSGNKKENRHEESHSYNIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH0</accession>
    <name>A0A4Q9LXH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0771p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000771">
        <property type="protein sequence ID" value="TBU12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0771p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8382" checksum="931AA9B6C84431B5" modified="2019-07-31" version="1">MHSYVVDIITGVQNELKAGVFKIFDKEMLSNNIKTKNNASLYMKEEPKYPKMKNPYRRGKDGGKEVKKNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI5</accession>
    <name>A0A4Q9LXI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-dependent RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0413p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000413">
        <property type="protein sequence ID" value="TBU13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LXI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0413p0030"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="1587"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="2322"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1867"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2296"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2535"/>
            <end position="2571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1877"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2299"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2560"/>
            <end position="2571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2571" mass="293052" checksum="ED048D86186E9016" modified="2019-07-31" version="1" fragment="single">MKPSNNNTQKNTSSLEKIINHITSTTTIKNHILESIITSHTKKAIIYLPDPSDILTTIKTISIIPNTGNILVLIDDTHFNERFNQYKIKFPHILAPSEKLLTYLPHKIFPLSYTNILCVQNNSKFHELQENHPKIISTLVLDDIKNIRNFLGLVRKLSNSLLNIQNIICLTTSPFLFIDYFHTKDHLFQCITPILYDKPTSFFYKKLLELSEIIYYKPCKEISSSNNTENNNNKLDNNSFENKLDNNSKLDNNSNTNSINTNINTNTNTNTNKNTNTTTNTTNTTNTTNTTNTTNTNTNTLQNIINYILTNLNTNYFKRFRILFEFLINNDLLDTEILLSSEESSVLNQKDILFFQKNSYKSQKLIFLFQTLSLFNTQKVVIVVKDSKIKGILNYIIRFYSGRYFDEGICDSNRFDRCDSKDYSRDYRCDSSRCDSNTNTNKDTNTNTNKDTNKDTNKDTNKDTNTNNQYTTNTNTTTNQYTNQYTNQYNYNVEISEIDFIDDFSDLIYLILFNYFPISTPHRKYILVPNNFKNYFYKLINSESKIECEIKPSLCIDKEISVLLLQKNSIFDSMDVGGEIGYKEYSSKEYIGYNEYIGYNEYIGDSNKGYNSKEYKEYNEYNEYNSNEYKGYNSNECKGYNSNEIVSNPSTNNTSNTNNTTNTTNNTTNTYTTNNNTNTNNTTNNNTTTNNNTTNTNTTNTPSNNNTIPFITLQPFNFNISTVKTENNFKKRNNNNHNNKRQQYNNSGDSNSYISNSYINNSYISSNSNNNNIGNNNNIGNYCNIGNSYISNISNTNNKNINTNNKNINNINTNNTTNNTTTTTNNKNININTNINTNINTNINTNNYHHPVLDIDANREFKVLLKNKEDFKKIIFILKNKDFIQKITFKNNKGIILMKKGFKYRITNISIMLSKLLSLPIICNTSFKSINNIFLNSTCISFGLMTYYSIFSNSYMFRGNNYIHFYNRSIVIYICGSVWEGGSGSGVGGNSNIDSNNIYSNYSNIDSNIDSNIDSNIDSNNINSNYSNIDSNNTSSNIDSNIDSNTNQTINNTNPNNNNIIFKVELSYTDIDKYIALDISNNVIDIYILLRVLPRIYISSNSYVGSTGNLYTGNTGNPYTGNPYTGNTNNNLYTSNPYTNYTNNNNPNNNPYTNPNNNPNNYTNYTNYTNNKYTTLHKKLQLFDTLDWRRVSIKEVPFIKERYDIKIQIDCYNKENKNIINKIIEEKRKIPFNTQESEFIFYTLCYYSSNVYFSKVIDTGRGSIYRNMLDGNVLDGNVLDGNNGRGSIYSNIDSNILEGNSNSGSGSIYRNSSIDSNSNRNSSIDSNRNSNMNIDSNRNSNMNIDSNRNSNMNIDSNRNSNRNIDSNRNSNIDNNIRDNILDNTRDNIRDINTNHTNTNHTTNTNHTNNTNQYNQYNHNTNQYNNNTKKLTCSEIRVILKDISFDNYYYLECLLSRKERFISLQLEEEDIEIFKNINFKELCIFIDSSLRERFVCVKSVIEGYYRGVLVGGSREGRGGGGIREGGSSISNMSNIRDSNIRDSISNSRDSNSRDSSIRDISNNNPNTNHNNTNNHPNTNTLLIRSMVVTPLSIIFNYPKHSMKNRVLRNFDSDKFIRVSFREENKNILKRNIYRDNSYVYDNYRDILLEGFYLGNRKYFFLAMSSSQLKGHNSWFVSPYMSNGIKGGSDSRGSNSSVSRGISNSKGMLEGVSNSSVSNSSVSSSGVSNSKGMLEGVSNSKGMLEGVSNKGYTSNSSVSASRNYNNTLPTITNNTLPTINNTTNNTLIGCDYIRAWMGDFSLIKNVGKYCIRLGQSLSTTIETVKIENDNYREESDIIRNVGVVGRDICVGGSIYSNIYSNIDNSKDNNRDSNIGSNIDNTDTNTPTTTNTPTTTNNTLYCFTDGCGKISYSLSVKVSKILGLNYIPSAFQIRFKGYKGVVVLDKELDKIENKYVKESITEIMYGSGSGSGKVDTDILDSSKVDSNITDNILDSSKENTNITDNITDNILDNILDNTILDNNILDTNLIDNNTNNILDNILDNNNQNTNTMIDPLAFLGLHSKVDLVLRPSMRKFESDYSFLEIINYSQCIGCYLNRQIIIILESLGVEKRVFMEILDESLKVIFRNVFREPFLILEKKCNFFGVFKEFKREFGENKMGFNGIDEMDGIDGIDENNNYNKYNEFRNEGRGDNRKVCRTDSKKVCRTDSKNEFKNEIFFRKLLFPIVGSVFGDLYRKSRLYLDKGRVLIGVVDCSGVLEENEIFVMTSRECSGDIYNIVRSDRFDRFDRFDRFDKGCDNNRSDTSNTQNTNTTNQSTNTTNNQNTGDDDFFVVSSTCIVTKNPCLHPGDIRVVKAVDRKELYHLKNCLVFSSKGRRPVFNMCSGSDLDGDLYFVCWDERLIIKKMYEPDLYKNENVLIKEVVSSTDIVNFYIKYMRENQLGRIANAHLALSDMSSKGVLDEKCLKLSCIFNQGVDFPKTGYVAKLPINLVPEAFPDFMEVNGSSYCSRKVLGVMYRRCGVLRLDQDINLGSSVNTSQYNRVGDGMDEEDGMDCEDRVDGLDGGNNSKSSSAYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ1</accession>
    <name>A0A4Q9LXJ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0435p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000435">
        <property type="protein sequence ID" value="TBU13424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0435p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="524" mass="61657" checksum="F793B80B36E55F44" modified="2019-07-31" version="1">MKLIHILNSSFIGLKKKMAGGETTQEGTIHRIKGYASSRLSLPEQTPLGRTPAKNRETSHIFFKWEDLKLAGLIKSKKMPDFWEKKISQGSCGDIVFFRTYIHDETIISLTANLNFVDLEKIVFIYCDIETSMVFSDLLSKINELVFYEDNVLSKKYSAHEIKDKEKYNIVENIIENLKRTHQKLTPGESIRENRKITEENKNFYLRLLNDKNFKNTVKIFESFNSVAPFLKLQCLYEYNGYFNNISITLSELNSEQFFKSKDTIIDKNIKRIEITASKITSKFLNELLNVNGLESLEINYSDILFESDICVKNKSIKYVRFWKNKGDRLCYFIEILNRMVDLKEVFFSSEETLKLKRSVTYNDILDLECHSDSVKFLFKNYDLSSINEPSLYDFCVSKSNLKAFSNLLNLKELNFFIINFENISISELFCASHEYKIKNMRLEKINISEKDLIFIANLKNLKKLEFEGCYVQQKTYLYCMKMLFINEFYIEPTYFKFYGQLSEETIQFINEAFKDRNSHINVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK6</accession>
    <name>A0A4Q9LXK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0755p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000755">
        <property type="protein sequence ID" value="TBU12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0755p0020"/>
    <dbReference type="OrthoDB" id="2195425at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="110" mass="13099" checksum="D10362A3B3F7A186" modified="2019-07-31" version="1">MLYVGGLPKIVFKTQKSKTKIEFKCCMTKEFCVLLYSDNTCYVDNQMDKVCFVLPIHLPSFIHKYDKKMSLSDSINKFFVFKSKEDKEMFSKYCQDFNDLKIRKIGYLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ3</accession>
    <name>A0A4Q9LXQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0417p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000417">
        <property type="protein sequence ID" value="TBU13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0417p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="534" mass="63800" checksum="4353A515A174137F" modified="2019-07-31" version="1">MFTLSPSNFSCLKKSLNKPIDLTEEINYSTKHLHKLISYNSTEISTIIESFNQISANISSIQNLNSSISTFFRTFSLKYQNFMAEYNNNDRIYRRIENILKKVHSVDEIIYKLRQVDKTSLKYNSDPNNIYNTIIYIMDVEDTVHVFKDYLIYPDLLQCISKTKNGFTNKIKCLVDEYLCDICGKYEKIGNKEIKDMKNKEDIDNKNKYYMIFDEELPVHFKEFLLIYNIYISLNLKQKFVSYFNDKRKNLLFNLSNINQMIGFFVCEYYFIKEEGLLNLESKYDCCLKKIVSETIFDEKNKNLILNFYKILKNYGFEYTILEEEIKKQCYISMDGRFKELTQSNEEDENICVSKESINTYFYYFYDLILDVPQSKHELTDILLKYLDNLMNLSNLNKSEMKKNILNFTEKLKRNYKFTCLGKFKDENETLQREIKEIFKKTAFIKNKDLKDQNLKIIEIEKLLDIFDKISDKEDFSFGVNIVKESLKDIFNNPKYKDEYKRKIDGYIIVFYSYIEKKEPGCKNILEDIIKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR4</accession>
    <name>A0A4Q9LXR4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0385p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000385">
        <property type="protein sequence ID" value="TBU13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0385p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="63328" checksum="3A85207CD2BDB6A7" modified="2019-07-31" version="1" fragment="single">MNYFISKKPITKTCDHILLGKLQPHTDLLLTVTNNTTHLYSFKNNHTLFLLKKDTFYEKILQIEKYPCIHCTKPINNKCDISKDVGDNICKDITNNSDVNDIGDNKDVNDIGDNKDVNDTNNTNNITDITDITDNTTNNTTNTTNTTNTTNTTNNTTNTTNTNTTNTDEVHHNIIILFKNAKISTLTYNHLSNCYITTSLRYFEKEDYDINIQHPSFFRLSKDIGIIHISPTHFSLFPLYNQKEQGCSKGSCKGYSCKGSCKGYTSNSSNNPYTNNLNNNPYTNNNINNNNTTDSNNTDNNNNNPYTNNNINNNNTTDSNNTDNLNNNPYTNTPYTPNTTNTLLHSSLTFKYLQISPTLYNITDITFISYSLHPTLAFLYNNKILITSYNYNTFIILSTHTLPLYTFKLLYSNEVLSCIGNNSVVFICKGGVRTVNINQYSRGLDKGVLDREMDSGLGKGVLDSSNNITYDKGVLDREMDSGLDKGVLDREMDGGFVKGVLDSSNDGTYDKGVLDREMDGGFVKGVLDSSNDGTYDKGVLDREMDGGLGKGVLDSSNDGTYDKGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU3</accession>
    <name>A0A4Q9LXU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0654p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000654">
        <property type="protein sequence ID" value="TBU12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0654p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="585" mass="68943" checksum="01B8D49F7A684BC3" modified="2019-07-31" version="1">MRYAAYIYRICFLVTIFSSNVYPAIPTQLYSVANIQNQQIPRILTYNTEFSRPEHLHWPHLITFSQPFVYNTYPLPPLQRVLVSNYQGSMYPCIEPTVSPSPIFLPMNPYIRPNIPVNLQDSLSIPSMIPGQGFVFAQEYNMVTNSMPPSIQLLSNQVNYNNSVQKNALIERMRKDENGSLKNDMFQLLNFDGHCFIETNRLEMLELLESLFRKRWIHKLESMYPLLEKNTKLILNNVFDNKNQVAQIGKNIKLCVKKILRMRKYGIGFGCNLSKMFSSNILSIFYTDNLPFIYLKPIYLLLPSWIESVVYNDVYIRNNLFYISWCLGLMKAIMEYNYECLKPFISQNLEKDERGAISYLYEINKEIIYNLNRYLLELSKNIFEVLNKGIINEIFEISADLSCYPSHCDRIFSIKYIFSGIPGIIFDVFIFVSNENLEFLKSIILEYKTMKKLPENSDLELDIHMKQKLDYNSYYTSQNVGSLFYNIARVYETIFLDKLFFINRIKNSQFLEFNLWMNKNISNLTQKITNGALPKYYDYIMFLETCNLFLHYISKIVLNPNLTPKTFRDTISQKIIDDLSQIYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV2</accession>
    <name>A0A4Q9LXV2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0371p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000371">
        <property type="protein sequence ID" value="TBU13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0371p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="317" mass="37902" checksum="B557E03B42CACA78" modified="2019-07-31" version="1">MNEISILEKLNHPNIISGRLFSNRFFYYLEMDFFEYDLLGYVKRNFLSIFDKKIIIKQIIDALYYLKLNKIIHNDLKNNNILIDENLNIKICDFGLACYKSRLDFPFNNISPSALEEYEVYSPELKQSIEYDEKSDIYSFGILTYFIFQEFTYKFETFIPISDSESNNMFLECIEYNPINRPSVERVLLSAYFDFLYDKMFCFGKLEDFTIETETGSIIKKYKKLTINIKSKRAVEILCCCHILTSLRYTSKAKKLNLTENRDSHSNLDLGFTQLTKKRFLYVDSDRTLKPIQFMTQLDRIEYLDFFYRNENYQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY24</accession>
    <name>A0A4Q9LY24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0503p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000503">
        <property type="protein sequence ID" value="TBU13207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY24"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0503p0040"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021026687" evidence="5">
        <location>
            <begin position="16"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="701" mass="79355" checksum="F03980608CC8DA25" modified="2019-07-31" version="1">MKLLFLLSFIFSLENKNDNKAVAVGIDLGTTYSCVCVFDPVANKPTIITFPNGKQTTPSVLRFEQFEVDGKKTALPVTGWNAFYENQKKPNKSNYLYAFKRYMGLSKADEKKILEYKHLVSYEMELIKSGDGSSVMMYTKDENNNIIKKVTPVDASRYILEGLKRHISESFDNVGKVVVTTPAYFTTNQIEATAKSAALAGFRTEYNCAEPVAAAYAYQMTKSGDKLENYLVFDFGGGTLDISVLEYEDKLLEVKTYSGDNYLGGEDVNDCIFSHFKDILKKKGVKFTDVNDELRLRAFVEDFKLSLCDKQNKSDEKDFKGVDCSHKDDFFYEGDKFVSLSLKTSEFNKICQRVFDKVTKYLSETDSEGILYKYKKDENGSSSNISKVLLVGGSSRIPKVRWILADIFGKRKIDHSLNADTVVAEGACWYAAYLSKYIAKDDLIQLADVLPMGIGICVDEDIFVPLLKRNTTIPSNGTKVFTTAVDNQPAVSIKVAQGERTSFKGNHQLGSFVLNLPFQAPRGVPQIEVTVRIDTNRTIHVFAKELSKNVEAQIKFDKHDYSLNEETIAKMLKEKEENEHLDKEVYDRYMAKNELVSYIDSVKSRMNGLSESVKNNVESAIVNVETWLEAEKNSADKEMFREKMETLKGVVEPMLSDKGVPKGEMESMESGKEMGREEDMDIGYRVRIWDIWLSIGYRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ37</accession>
    <name>A0A4Q9LZ37_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0246p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000246">
        <property type="protein sequence ID" value="TBU18337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0246p0050"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="338" mass="40162" checksum="F62037058D80F513" modified="2019-07-31" version="1">MKVRRAYFTLFIIFLISELFQKILLFYSQKNVITECTETKNYILYEKRYESAKRSIVGLKNDNFVCYFNSLIQALYFQNDFMKGLFLYEHTKEQKCIFILKELFEQMLNDRIVNTSVYLKEILELDSNMEYFKFGCFEDAGTCLDIIFLRILKEIDVKKFSDLNNVTNKYFPINLYLFQMKTTYLCVECLEKNIIYGDNYNLVLYLENSIQESINKSLNVESIQCYKNKFKDEIHYAKILREFVNLPSSIIIKNTHDPSSNGNVLIDEEIIVQNQKYSFKVCVFYVKDLHYYTVAVLGNNYYELNDNSVKKLNIESIENLGFSDIPDILFYEKLNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA2</accession>
    <name>A0A4Q9LZA2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0230p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000230">
        <property type="protein sequence ID" value="TBU18737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0230p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="589" mass="65998" checksum="74DDC23AE9DC9D99" modified="2019-07-31" version="1">MEKQIFTNKDAKSGLDTTTVEIFCAESFQDRTQGDNTSPSLTLFQEELASDQKISISDAEFQSSNSGFNADSVSQVFVKQILCSRPHFDPASLDASPVYQEEHYSSIQTTELNTKPLSIETSQSKLNYPVGENVSIRCSPLSNYPDSQPFGARNKYPQYEKLHNINNPANTPSEIDEVCTEENQSYMHKSNDSGFKHILTHSTAAKSYNSQNTEVDLETDLKDDTGLERTDLNTEEKSLSNMSSVYSQIDMGKETQTGCLRNIHGNLSSEEYGIETQGKFDPVSFQLESENESLIDAILNSSSESEKHTPKKFYKEISFQKINEGIVLETSNQSNYGKDAPQKSTEYSEIQDSKEIIEATKQVSPNPIENRSDENFPTTPFSTQNQDVKSKKMSCHEEIEIELFDESIHLIEGASALPEEDCTGQANIKVLLDYQPETTSCELFRLNESYMDDAYLNYSDEDSYTEQFNSYSSLTSESKHYIDTSPSPKIGELSAIKEENEESSEDLLLPFGSNKTFQSTANESTSNSEGRFLDSHSISSIQTQAITSSNLNLDLDAHQIPQPYEENTKSNNPTLSEENTIDLLKNSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC5</accession>
    <name>A0A4Q9LZC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0478p0050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000478">
        <property type="protein sequence ID" value="TBU13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0478p0050"/>
    <dbReference type="OrthoDB" id="2195824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="31812" checksum="4ACDC603D128AA25" modified="2019-07-31" version="1">MNDSLPKAVVNEFFKRLRSYNCNSKCADCNKKTPIWTSLTFSVFICAECATKHREMGVTITKVKNTVLDSWTLPDLRRMSVGGNERALVLPQTLDIFEKYRVSKWYSIEIDELVTISEEKMPNDEFLKVKESVKPRGNRNIVIEEKEPPKLGSAVSHIPTESFEKNNENAKIQTKKDKSKEKKESVCFVNISTASSGLQKADTPSYKLTDSSNLHRVGLGNVQLEKEEDKGRYSYKCAPVKHVYVPKSKNEKDDVVKDTIKKIALGGKSVIGNIVNKFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M097</accession>
    <name>A0A4Q9M097_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0148p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M097"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="519"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="668"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="731" mass="86434" checksum="132C3C7E2AAF56C4" modified="2019-07-31" version="1">MKNKPAFLFENNLKSKELSIPFHKEIKTKKDELCEELNIILEDMENENFEEDVNNEINENLENEENAKVKDMKVEDMKDNDLKNEDMKVEDVKGNHMKVEDKIPSDGEDSIINTGIGETSLLPDFDTFISKSIFLPKKNELIKENNFNKICKSTIQSEKSRENSSLISENNFNKICKSTIQSEKSRENSSLISENNFNKICKSTIQSEKSRENSSLISENNFNKICKSTIQSEKSRETNLFLNENNFSKICKRERQFNPESENMLIKEDLNREYQCLDFLEDFMVNLPCQVKKLREYWRYLENEIKIYKKNYIDLEKSYNSTKFLCDNKTKENYNLQSNIKMLENETHKLKDENYKFTTEVGVLRNASDQMKNDFKMLENLNFNLNEQIKNANYKNKVLLINKLLAKKIITDSFFLNEIVSSKLTNSMNENKILELKVKNINIKLDTEKNHVDCLLDTIRNLEDEVLEYKKKYFNDFFIFNTEIQEKNIKFSELKNNSDKDTSKIFELTNLNKKFEAKINNSKETTKVLEKSLLDLKNEKNTLENELNVLKINEDKHNTLRKDLTTEIDKLKAIIEENESKIKYLEKENEKNKLEKSKSTKIIQTKTFNENVLLKNKLHGIENLFHKEKRKNIFLVNLIQKIQTETQSLENEVHFIIDNVFENTKIFKLEFNNLIKSHKNEMEKTKSNSERKIKALNLELRKYKKNLKSKKVKPSVEEPLDSDLWSVFNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H6</accession>
    <name>A0A4Q9M0H6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RuvB-like helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0358p0040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="PITK01000358">
        <property type="protein sequence ID" value="TBU13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0H6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0358p0040"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="9">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB-like AAA-lid" evidence="10">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="341" mass="38785" checksum="91E512560CF89C2F" modified="2019-07-31" version="1" fragment="single">ITTISGSEVYSLEMSKSECLTQSIRKCMAVRIKEKITVIEGEVVEINIEDESRNFGKIILKTTEMESSYDLGEKMIEQLNKENILVGDVIQINKETGKVFKIGKSSFKKGDFDALGPDVKYVSCPDGELIKIKEDEKTVTLHEIDVINSRTQGYLALFSGESGEIRNEIREEVNKKVEEWVNEGKAEFITGILFIDEVHILDNEAFSFLNKISEDEFCPILILASNKEILKIDTQDGVEEQDIPKDFIDRALIVKTDEYTGKEIESIVKLRMEEENIAIDEESLKYLVDIATNTSLRYSLNLLTFSNARASKRNRSIILEDIKRVSDIFLDENRAISCLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N0</accession>
    <name>A0A4Q9M0N0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0241p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000241">
        <property type="protein sequence ID" value="TBU18430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0N0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0241p0030"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU18430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="500" mass="57844" checksum="0EA75FEDF7214CC4" modified="2019-07-31" version="1">MQNNNINVFLRIKPSSIQKPSISRNSISLNQTTYNFDRIFYKSNQQEIFETSSKDLVNKALQGYNCTIFAYGQTGSGKTYTIQGTKENPGIVPHTLKYIYTKYFCANKIFPGTENPLKNKENFNENLESNRLILVENTTFKMYFIEIYNETIYDLLNPSKSDIIIREDCSKGIYLENVTVYQPKTYEESMSLYTTAVESRRTSSTSFNRQSSRSHCIFTIIIETKKGNVTQYSKLSFVDLAGSERLGTKENLIGFNCNSTSDTNLPVQSINLKETSNINKSLLFLGKVISNLSSISVSQKDKQYIPYRDSKLTHILKDSLGGNTFLVVIGTITPDISYMHNTLNTLYFLGGVKEIGNKPEVNVEVNENIEEMKNEIKKLFLENKELKNRIESINNKEFVNNKDIENLENIKNENFEKKDVMNSKNIKFEENNFNEIKRVLEKVSEIRKDIFELENLFMESVSKHFESHKNEISKVKKYFKKECDKRNKSLDEIVVKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q7</accession>
    <name>A0A4Q9M0Q7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0335p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000335">
        <property type="protein sequence ID" value="TBU13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0335p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="228" mass="27058" checksum="4B033599997F9498" modified="2019-07-31" version="1">MVQLEKKIQTEFNSIISYMGTSEKKRILYGFEISVFYMRIIFSNILLAIDDGNFRAKIYFHTALLDLSCSLPKEMNQLFKTYFFRISIDLFFSLCFNIEDNLSDKLLLSILDLTNDVLDNRNKKILVLNKFKDILISYSDSRFLHQNIEAIKFYNIFNNQATHNIHFSEFFNKINILTEDEIIYLKSVNINMWLTRLIETKVCFTLIKIHFYNYTLQKKTTAVVNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R9</accession>
    <name>A0A4Q9M0R9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0106p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0040"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="481" mass="56516" checksum="7410E1C8B0AD25B9" modified="2019-07-31" version="1">MIYYGDNIQNLEEPDVDASFEILADSENENSLLFKTPVDILIFEYSNSYIIRSMYFDNSNSSEINEIYLNIKDITKGNIDIHMFKECLNILCYGWNYGVSGLNNENFLDFIQLLSDLSCYSESDALITLYKNLLPFLFSYAANISRSNVFNLPEIEFIKYREYFLPFLTVLYASVDIFFTSNTKELVFIEKNEIRKLYLDGMISSEKIIIRTTPIALKFMYKDYSKDKKIILSKLVFSYEILGIRISSDDRYYTAYKNSDIADLFLKRNAGICDVKTFFFSVFYTHDFKKNERIKYIEFERIDLTYDSRILGFGFYYLETLILVKCKFNKYPKVLSNVSFYFSNLKILRIIGFRLTNRFFNNLNYLKIETLDISGSNYVGSNLKFCINLPKLLKEFRMDHSYPNYNILNSMILNDNLAVLSMRGVDFTCLKNFTSFRNGQKYFHCLDLSGCILDDSMLNFFSINIRSKILILEGFANMNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0W7</accession>
    <name>A0A4Q9M0W7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0221p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000221">
        <property type="protein sequence ID" value="TBU19104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0W7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0221p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21817" checksum="5313D9874D480FFE" modified="2019-07-31" version="1">MLSFFKGIDEIYVAFFSNTDEIIEKICQTSALKNIKILNIIYSKFTTKDEIIFLKKYNIEKINYIILPNAPKTYFHNSAIYSPVHDLYLTSIYEISENNKKVFAYKNRKLNKNIRKNLILVCHHNESMIEKVENSNSLSSMFLCVKLYNENFWFGFFALNLKEIKNIDVRFADTYIKDFEINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M125</accession>
    <name>A0A4Q9M125_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0082p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000082">
        <property type="protein sequence ID" value="TBU20374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M125"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M125"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0082p0030"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="453" mass="53107" checksum="C2838D5846B88338" modified="2019-07-31" version="1">MNDIRLLQKKITYSERYTSNDYVLRHVILPKEMVHLIPTDRLLTEDDDGWEHYMIYKPEPNILLFRRKKDNNDFFKGVLSKMVVTKGVVVNDRLITNRVLYDKGVLVTYDKGVSNIPLNQRVLIIIYYFYINNTLIFHLKESPFFMDKILFNEVLSCSRFFKIGDRKKIYSALTGVKLTNKQKEIIHEILRKGCVDTGLIYCDGSCLEFKRERSFNKQRESVVDNTSMMYKENTNINNTPLITKENTSINNTPLITKENTTMFNTPLNTKENNHYNNTPSINKENTTMFNTPLITKENTTMFNTPSINKENTGITNTLSTNKENTTILNTPLITDEVLEKTKCFCFHNFGFKYASSLQKYLLCCLFNKKSLKEVLLVVHNIPSFLYLKGVCLLMLYYSTGDFKFAIACYLSVRRKFRKIMEISNEEIIKRLEGKRKFEQIFLYNNDCKNMEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M172</accession>
    <name>A0A4Q9M172_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0070p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000070">
        <property type="protein sequence ID" value="TBU20440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M172"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0070p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="22626" checksum="78F837C56B2A1B64" modified="2019-07-31" version="1">MVKVREMIMLWESRIKSTNTLEKPLSENKTKSDLAVIRNKLISSDFIEQITCVDVEEKETKLIGEKVAQNVVKELMLQITYKYSVPEVLNIVNNMIDEMKKARIVISSNKSQPRNNKKRRKEIFKKPTTDLQTDTFSNDFLQPETIEKNDKADVKINTDTINVAKKKKKWLDKKRWETMSQFKDRLKRYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B7</accession>
    <name>A0A4Q9M1B7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0307p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000307">
        <property type="protein sequence ID" value="TBU15718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0307p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18247" checksum="70BC4620217F753E" modified="2019-07-31" version="1">MEKCRDFFLKCILFKIKSMTDTFNLENLLSIEFLLVTSYDKHGILQANYAPGMEENKTSIFDFLTDTYKIYNYKMHFKGKLIIPALEISIDFLKEIFDTCLKELNKRSKIFLIDQEEIGICRDFFIKCQLVKIQTASDAFKHKNISSIELETIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M9</accession>
    <name>A0A4Q9M1M9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0313p0030</name>
        <name evidence="11" type="ORF">CWI38_0284p0010</name>
        <name evidence="10" type="ORF">CWI38_1114p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000313">
        <property type="protein sequence ID" value="TBU03327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001114">
        <property type="protein sequence ID" value="TBU11617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1M9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0313p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1114p0030"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU03327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="275" mass="31787" checksum="CB484DB2AEF048FE" modified="2019-07-31" version="1">MQNFLSQTRRISEEINTLTEYKEKFIYISNTKSKSVLKESEERNLESQIKVLNNMFSQLSSKIKLELKKMSEENEKIQNEEKESNFLYETRNNHWQVLTKKLVQAINSYRESQVNYNNIEKDRLKSQYIIAKPTATEEELEELTSEKGQEHLKNAFSLGSSSAKQMYSRAKERSNNIQKLAESVEELCQMISDLDEMVKSSDVFIDRIGVSMSSTKHSVKKTNKDLESALRYQRSAMRIKRYIFAGIGVVVLIILIWLGIKFLGNQNSGNGGNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M265</accession>
    <name>A0A4Q9M265_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0017p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M265"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0010"/>
    <dbReference type="OrthoDB" id="2191799at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19777" checksum="8E6D8735153726EC" modified="2019-07-31" version="1" fragment="single">MVIFFLLLNKLYNARKNELVSVSDSSRWLKRGNIRPRNETVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M268</accession>
    <name>A0A4Q9M268_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0022p0090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M268"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M268"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0090"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="70"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="272"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="46909" checksum="835254073862B9AB" modified="2019-07-31" version="1">MQFDENNNIINQDINNNIITNDNTNNKNTFSNNTPDIIEKWEHFGIKESLLKGIYGTGFITPSFIQKVAIKPMMMGKDLRAQAQSGTGKTGAFAVGALQSIDETIDATQVLVLVSTREIAEQNAMRIAGIGMHMNIKVTLLCGGFAVSENISSLSQNPGIVVGTPGRVLHMIQANHLKTENIKLLIIDEADEMLKQGFKDKVKAIFLTLPVDILQVAMFSATWEKEELDVAAEILRNPVIIDLRQDEQTLKGIDQYYVYLGPKPARGSDMLKVDALVDILESSDVSQCVIFVNTKSKAKYLYDVLCTMKFPVEVIHSEFTQQQRTDILNRFRASKFRYLLSTGLLGRGIDIQQLSLVINFDIPRSQDIVTYIHRIGRAGRYGRKGKALNFVFDDDLPVIQEIEKHFHTSIGPMPQNETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M7</accession>
    <name>A0A4Q9M2M7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0169p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000169">
        <property type="protein sequence ID" value="TBU19932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0169p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020887457" evidence="1">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="480" mass="57146" checksum="B108A63BE668B1EB" modified="2019-07-31" version="1">MILFLWFITFIFEAQAKRNKKKGKVKKFIQKEKILTTDTNFLENIKVEDSSNTNKETKESFLECDFCNIIDETVVLKIPELVAIDDLENENRNDARDIQATNLTNEPNFNFVHDHFFYSQVYIDLHAYIGNLEIEFIFINIIYNRTITLTDIFQLINTGFTFKSLEIPEIMNIFIYVGECIQLRETNIDYSTFYDCYSIIPYKMAFFLKHLQLETKSLLISEFPSIFTLIFKIHNELNIEKTKNISYVSLYYYIKLVESLLVCDVSYFNSQFSVFSGNKIKLYKESDQFIFFREKFFFCIREIFSLVPNFTYQYYVHELCQTVMNNKILNAENNNSEENSSVASIYSIILMTRNRTAKTIYTLIKPESPINTTNIDDISLKIHDLTNFIERSQRGEYRKHLYVNIQLINSYFALFYNYDFFSKYFIRNYDEYQTTIKAIANLRKSLHDSEKICDPCFKKKLVYILKKLSTFYKISVKNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Q7</accession>
    <name>A0A4Q9M2Q7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit 11 of transcription initiation factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0188p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000188">
        <property type="protein sequence ID" value="TBU19841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Q7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2Q7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0188p0020"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15703" checksum="5D0F41664837DBE3" modified="2019-07-31" version="1">MPSEDSNNINNEDINTSSTNEESSSTNIYPSRITKILDTFTDKEILRYESFRRSGFPKNMIRKFTNHTLKQACNPNFIIAISGIAKVFVGEIVYEAKAVQSDLNEEGPLLPSHVHEAYRRLCNRCPNMKIYNKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M366</accession>
    <name>A0A4Q9M366_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0041p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000041">
        <property type="protein sequence ID" value="TBU20637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M366"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0041p0020"/>
    <dbReference type="OrthoDB" id="2199106at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="26650" checksum="92AC133F2BBD77BF" modified="2019-07-31" version="1">MIFDIILVSIIIGVTIYLTRKSKEKMASLLPKFDSLDKYFKKKIDQPVSIYQHLLFYSGNNSIYNMAAILTLKKDFCPFYYILSNSDFNFILTGTISAKTNIFIVSKKINFKHLGMKYAKKSKTCIDGYKMYYSGFTSVLQIKDNYMINFCSKYPIDVFYLSYLPEKYSKVNNYESKFYLKSNIENIFKKTFFDDFLNVLSQICDTKWNLKTYEENIKAFDKKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M367</accession>
    <name>A0A4Q9M367_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0126p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000126">
        <property type="protein sequence ID" value="TBU20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M367"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0126p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="522" mass="62567" checksum="8A5A6A15FDBD707C" modified="2019-07-31" version="1">MFLYRLIFALYNSETILISCGSAKSNIDPSVSLNDITNFLNELENINEDLVIKDYIKETSFGVRNWDEFMFESNSFFYMVCVEAKHMYNNRAKIDTRVFRSLKYAYDYMHVNQNSNNFFLDTVYELMDSNIAKIFGCNFENYKGFNDDLKIYFCKSKHQINIQEKIHFFLKELDEWKIRSRYRILFISDHILKESKFLYLEQPMMNFFQTELFFKNNFLYFSDNQDNLLFVGENDNIRIIFQHFDNKKSESKIHSQSADFCVYELEITDVVFCNSIKFYFLFGNDKEKYLKYITSPECNLIDNYDIFYYEANEFAVKNFKENIKIIFGNNLFDFCENCINLLKFCESKVMFSHKRSILMKKSFLKKLQKYFHTQDISFIKEFKFYHSDHSKFVKKITKDAFINSDASYDALDSQKSYYSEGFYPNFAIHITNLGKYDEESVTKKVFFQDFLPNQKIGISLKFNKKKTFLFHVNLVFVFKVEENELKLFVFSENIDSFGIIDKNIGVFNENWYKKITISILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M376</accession>
    <name>A0A4Q9M376_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0162p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M376"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="231" mass="27511" checksum="A51019D17AA944E5" modified="2019-07-31" version="1">MKKYKCKLRFIFFFSVLSMSQIFYQGIFLYYQQKKLKGIHKNESLPVLWNYVYGIMLSELLETSFVINSIHSGSIEYLICTVFPVVYTFSAILLKYYLCDANITIDLIIQISKFLYSLSIYTEIKAHISWSYYKRLGPCYSYLKGYIISENLKALRNLCYFHNVIIYVYYYKNKPKIISLISVFLVLTEFLSHIFDKKIPKKVSYISISLWICEILNICRMIKVTYDIYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3C4</accession>
    <name>A0A4Q9M3C4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0149p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000149">
        <property type="protein sequence ID" value="TBU20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3C4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0149p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9265" checksum="1863FA8EAF9AE9C5" modified="2019-07-31" version="1">MCFESSLWHNKRSVKQIEKAVFCYYQDRNKTVQIYFADRRRGLEPGPNSEEGFEKGAMDAIKRSEMHEQPAHRSNQASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3G4</accession>
    <name>A0A4Q9M3G4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0129p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000129">
        <property type="protein sequence ID" value="TBU20121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3G4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0129p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="23197" checksum="02AD61A229C3AB5F" modified="2019-07-31" version="1" fragment="single">MMCKAILKSINIKRNFTFWALYILSISKVILTQKTIALHFYEAEEIQLTENGTKNCDYFDESFHFDDQKPILYSLDSNSKVLQVFIINLETFFLNFSNDEEIQENQQHNMHININLVSYKEFLYFYNIVMCFPFLIGNVNENRYQLMVKICDILKIKTNKRFEEFIRLMLVSLIFNPEVKNKWKFISNSKNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3I2</accession>
    <name>A0A4Q9M3I2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MADS box-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1993p0010</name>
        <name evidence="9" type="ORF">CWI38_0099p0070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001993">
        <property type="protein sequence ID" value="TBT97925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3I2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3I2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1993p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0070"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT97925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="237" mass="28233" checksum="E2163388574567BD" modified="2019-07-31" version="1">MTDRKKKIPRRDNEDNQYHQEGQPPYKIMDEDIPRHHYPEYMDGYQENIPENYHYRRYNYGFEQRPYRQDLERFQSPYPEYYNPPPYRKGGMVSAPPESKESSSSDSDTDTKKRKTGRKKINMAYIEGKNKRSVTFSKRKKGIMKKAYELNVLTGTQILLLVASESGHVYTFATSKLRPIISKHENLIQQCLNAPNTPETNNYDIKNEDVPYEKEDYYKDNYYNQGYDYYNGFEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3P5</accession>
    <name>A0A4Q9M3P5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0087p0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3P5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="5963" checksum="39EC96329B24C0A6" modified="2019-07-31" version="1">MDVIMRAEMHQEPTPPLKQAKRDEDGEPTININEASDLEEETVVIQEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3V0</accession>
    <name>A0A4Q9M3V0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0076p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3V0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6755" checksum="46CF235138FC35A2" modified="2019-07-31" version="1">MNLKNYYLESRKHFYECESEEESDNLEDLEEIKKWKERSGIKELLFVCRKPIANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4T3</accession>
    <name>A0A4Q9M4T3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0047p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4T3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="780" mass="92681" checksum="DC8FA26BE5DCEC46" modified="2019-07-31" version="1">MNISNMILYLRIGHNIKIMSIFLFICLFATLKADNPIVLHFYNESNEQESNLTRNKEEKECFSGFVKRRYNCFKHEECIDCINHTITNRKRFLLSFKLNNETEKRINIYIRSSLLKYSDFLYFLKSLNYIHDIKENLKLEDYVLLIHILDIFKFKKDEIFNQFVRITILSAILNNEKKISNGDLVKKITTSSSVFKSIIYEFGKIYLFDLESLFEEIPEKNIRKKIIQKSSSNFCSNKDFFYLTSGFNDETRKRIRCDIKFIYAFEKIFRLIQPHRVALYYYQSRDIVLCASLSRFCRSCEELCFYAWKDNKFLEHILEAGIFDMARILFFYDCQFSSFSEKFFEKFLSLESIYIFRCSFESTVISYTTFAYIQSLVSILNDIIKSREFSKYLYCSSNRPYKFETFDVKKIINENRNSISQEALNCTKYQIYFSYKIIIDFFVAFKLSILNLGKTEKIGLCFHDISMNELKIQSLDISNNIKFLGICKSKLTDAFLSNILLFPNLKQIKISASSLIFRKQPRSYANHLIMHELVITACKFENPNGIFEFINSMPNVKKFIFHSNDNFSFCLKIFKNNRMKLDNLEYFHIGEKGNYISDYLAFTDLSSIIILKLIVPSQAGSLHKLFFNKRFNNLKWLAIDSFKIESMDKKSLANCITLRVLAMYHSKCKKIYFSELFDRKKEYSLEKIILRDIPIRNLDIVFISNLKHLKVLGIYGAHLYFNLINFFRLFSASSFKQKIKLYFDGKYSLNESIHHFKELSGIEIENKIVWYENDQLIYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M594</accession>
    <name>A0A4Q9M594_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0266p0040</name>
        <name evidence="5" type="ORF">CWI38_0009p0120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000266">
        <property type="protein sequence ID" value="TBU03613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M594"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M594"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0266p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0120"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="162" mass="19443" checksum="77B24B8516C7E506" modified="2019-07-31" version="1">MRRNNALVSNHFKKSSLIFKNWFDKNANKERRRERRIKKAKMIYPMPLNKLKPVVRCRSARYNWKERYGKGFTFEECKSAGLDYRYARTIGISVDSRRRNTSKEAFDQNVLRIKEYLSKIVIYKDRKEAVKSKVEQYKGVLLPIRNEPKKIESISVEEILNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5Q7</accession>
    <name>A0A4Q9M5Q7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0012p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000012">
        <property type="protein sequence ID" value="TBU20886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5Q7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0012p0020"/>
    <dbReference type="OrthoDB" id="168403at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24377" checksum="16A4DCD90CD5B0D4" modified="2019-07-31" version="1">MCDIPSKKKKRCGRKPKDYSNNLARIKNTPLNRLGTFRSISFEIAIPKSTLFDVFKSGKYTKRISSTDYFYGKIGIWPFVYQEPAQRNSKNRVKGTMITINVESVTAVHCKNMIIDNVISAIKSKFLPAYKRKIIYVQQDNAKPYFSDNDADIVALGSADDWNIKFKSQPANTPNLNVLDLASPHTIDELINCQLLEKYVCSKEAYNKAKSNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWA5</accession>
    <name>A0A4V2JWA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-alpha-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_2434p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002434">
        <property type="protein sequence ID" value="TBU07212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWA5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2434p0010"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="19024" checksum="B67FA9F64C1E8A66" modified="2019-07-31" version="1">MMVEIRKMNYSDLESVQEINTKNLPENYKMKLYYYILTLYPDLSFVAVENGLIVGYILIKLEKEDLDINLAYITSLCVDFEYRNRGIGKRLIENGIKAVKNYLKENMSHINSINLILNVRVSNNLAINLYCNKFGFKNTDLIEKYYHNKEDAYRMVLTILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB5</accession>
    <name>A0A4V2JYB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0065p0050</name>
        <name evidence="2" type="ORF">CWI38_2666p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002666">
        <property type="protein sequence ID" value="TBU05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2666p0020"/>
    <dbReference type="OrthoDB" id="2197301at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11171" checksum="8994FE8A91B51B75" modified="2019-07-31" version="1">MNKNTKIEKLKDEIITYPIIKKIPLVISYFLEELSCKIIPKKIINNLSVFKGLFIIGVTFFSVNILPVLYIYKHDKNRIEDTPLSFIRNLNLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF7</accession>
    <name>A0A4V2JYF7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0015p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="620" mass="73991" checksum="E2EA50575E8A0945" modified="2019-07-31" version="1">MIIFIFGFIFASQKTTSYTREEKHMNATENSFPLQYVGNVANRMNSESKRKIDNIGDTNKFFSKKNKISDDHNIFTQTEYQTEILKMVSSRDLTMPDRRFKLSKFKIYSYYENKYSRNIIATSFDKSCKKTTYLEKDKHDVSDRHTDTFQGNPMPSCSYEISVSPQRKKNDVKLKPKERNLKRFNLKTLGADSEILIKNQFQNKKLAAVEHMSKSNSNKSLVMRSLRILVSKLKNISEDENVLGLLEVISPHLEGENTELVQNIFKDKEKPGEDSNLETDTFSSFETRLNEKIEKIRSAEDISDKELYILLEFSNHIVEYEKNSARESPSTNKNEILSRFKFDDLLDIFYNKEEYLILSEFAFFLNYHDKKKIEIRQNHVLYVRFIFSLLKKYINQIIKLRNNIKHHDHNLTKYIFRCRCIIFMLLHGLEGFVIRKYLYFAMSNLIFQNEICYRKKFFSNYLVFSFHLNIILHTSFSNISIFKSKVISKIYDLFSLFANSEDGSNTLNQNKLFREFTHKYMGIDTIRNTIEVYEYYKTKSFLLKKFKFYKYMESLIYPKYANNDSNMTDLNNDILLDIFRVNLLVEKLHTRIIFHHLNFKEQTYNRSFEELIRKIEQYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL9</accession>
    <name>A0A4V6MVL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0952p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000952">
        <property type="protein sequence ID" value="TBU11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL9"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0952p0020"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="13427" checksum="AEB88C197B9E1081" modified="2019-07-31" version="1" fragment="single">MIFKKNMFVVMTRGRFAGCKATVIKADENSDRVVVAGIAKVPKFSDKEEKVLKKRMNVFVKKINKIHLLATRYKGDTGISNINFDGAFESPASKKTAVMQVTKVFETALINKKVPWLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN4</accession>
    <name>A0A4V6MVN4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0418p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000418">
        <property type="protein sequence ID" value="TBU13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0418p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020590067" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27543" checksum="70AF917C4A571596" modified="2019-07-31" version="1">MKMRKSSSLVFAMAIVFSYIKASSASESFEAEYKKDFEAFKYKNQLRALKESQLACFTWGGYVNYFSFFIIDPKQDKSVIDNFLKVGKTTIKDYVSQSDHPKELIYITHLKFEKFSSFKNHLASLLEQNQTSRIRNNLKILEQIADCIAINLKQGFIHNSIYHIFINIKKEKRVILYGYHIFFHHCTRNMVKIKDFEFDIDKNDKFKAYNYIAFMIIKICEGGRFEQESEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP2</accession>
    <name>A0A4V6MVP2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0217p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000217">
        <property type="protein sequence ID" value="TBU19274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0217p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="87095" checksum="56D35420702A728E" modified="2019-07-31" version="1">MEKNEKNEEEEADEEFEEDYEIKILHGYENNYYDISKPFFIYSKENLVNFEVLDSILSLNMSENKPKEGIIECRYQLSYFLRLTRDVTEVTNNLNIQQFKYILMTLKFLKAVENKNITKLLQVLIFNNFFYQKDYKLRNYNLHLIQILNSSFFTQIDFHLKRNIMSSFLNSLMIRYDFYDENLIIFKNSKELFDYSMFSEHIPYKNLMINNFDAFCSVENILRDSNVLIIFQILLKEINIKSLILNNFFRHLDPDENFAFLISKIEIFKAFTISNYKIPASPFFLFCLIVSINNNIEYLRLENISYCRLNLRGLLEGKKLKGLILSKIGLTENASLINESRNVYETIEYIDIQGVFLNHSIWHEIFQYTNSSKIILHFNNSDIEEIFINNLKKFEIQKNSVLYLEIKFNSSTLPRGFCNSLIHFKNLKTLKLDGYIIYEDTESLLYKAIYYMKELECLVLCQNCRNTKPYIFLLQNSKIDCLDIQSTSNNNDAIMIEFFRLHKSMTRISIKDAKVSSLCLKEIFKQKNLIHLCLDIDILPPQVDQESLTFKSKNIHNLDLCNNTLKYIEGVDILSKLYRVHTLRISKCNPPPGYLSKLNKKCNSYVKILTYEYGILDFDDLNRIGKLGNLLKLNLLGCKFSGCSFFDLVTSCKFFKSLKTINLLNSNIKMKDFQCMKRFKKLKRAVFSFTEFNLLTLKNSLASLQICKLKFHTMLEDSNYNEFCLYLNESNIYILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVP9</accession>
    <name>A0A4V6MVP9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0076p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVP9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="41590" checksum="36B6A1E7614D8EF9" modified="2019-07-31" version="1">MKKEKQKSFIYSSVDFELTKPLQSYDIDLCLCNYEKIRNGIFSELRINETQKRIKNKLLSIDNDEIELLFYKSKCVGDSSIEDSIDSLLSDVGDNNIVEDNNIVEDIGEVEGNDEVGDNNIVENNSCVENIREIDNNIAVENGLNRDIFDGNIDNKSKLNTGKFEDIKNDSVSSDTLNEDDFLEQNEVNLDYIEDEAELSGSGSSDSVVDEKEIFEDLKKSKFISTKKVKDDYFEGLSKHGEEMEVMDVEKLNKLKEKYGSKKIDFKYKKIFSKREFKDEDESGIDVSSSEDGFLYSAINEFESEISHEKVCDIEETEFAKSLDENNFMEKSLVFSNKQDVLEEMVKDKGKKNNYAFQRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KSL5</accession>
    <name>A0A4Q9KSL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_2244p0010</name>
        <name evidence="4" type="ORF">CWI38_1421p0010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002244">
        <property type="protein sequence ID" value="TBT97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001421">
        <property type="protein sequence ID" value="TBU11035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KSL5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KSL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2244p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1421p0010"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="324" mass="37552" checksum="808529A983273636" modified="2019-07-31" version="1">MKNTEPLLESSPDRFVLFPIKYNDIWMAYKKAESSFWTVEEVDLSKDISDWDKLNSNEKHFVSHVLAFFAASDGIVNENLLERFASEVQIPEARCFYGFQIMIENIHSEMYSLLIETYIRDSKEKNRLFHAITTIPAVKRKAEWALKWISDHKSPFNTRIIAFACVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACILHKHLINKCSKERILEIVSEAVAIEKEFLTDSLPVDLIGMNCKLMCEYIEFVADRLLYNLQVPKKYGTKNPFDFMENISLQGKTNFFEKRVAEYQKPFVGIQGNDTSFTTDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWL0</accession>
    <name>A0A4Q9KWL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1401p0020</name>
        <name evidence="4" type="ORF">CWI38_1312p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001401">
        <property type="protein sequence ID" value="TBT99276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001312">
        <property type="protein sequence ID" value="TBU11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1401p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1312p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036357704" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT99276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="139" mass="15281" checksum="7B043B83CB980DF6" modified="2019-07-31" version="1">MHFKTQMITCIFCYLSLFTSVMCSVDEEKPGSESQVLQVPAIEADGRQLLEATQDTEAVEPKEAVESTEAVKALNLEDPEQETEKILDEDNEKESQGEGVVRSGEIKDELDRYANPQGYDVAEHGEANEGRSSPCGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1D1</accession>
    <name>A0A4Q9L1D1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0877p0020</name>
        <name evidence="3" type="ORF">CWI38_0349p0060</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000877">
        <property type="protein sequence ID" value="TBU00866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000349">
        <property type="protein sequence ID" value="TBU13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0877p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0349p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="314" mass="37181" checksum="19337A6ED3B0DBFA" modified="2019-07-31" version="1">MQPQISKPAKYDSRPKYYSNREHTESKKTYDLQDTIKDLCGCTKTKKFKNEATKWHRGMTFGHEDLKMNIYKFCCTFKVPLLDALAIRQMDEEEYSSLVWVQSEDLKKSDAFTDINLREALMIHVFYVLTKGSFISDHLSDEFPRILVPYLSKEQPLSLYAQILTSNNMKALDSEWIRKIPLSKFFTDDLFKRITKMVTGYRLMNAVYVGTPRPNLDLQTLKAVSVIKKMYAKGLYWDFNPIFRNYELYHALGSFQDNLLNLIDVAFDAEEINNLKEFKLLHVKPNFDSRHVEFMNWDESLMEKLRWPIKFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6L0</accession>
    <name>A0A4Q9L6L0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HemK methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0390p0010</name>
        <name evidence="7" type="ORF">CWI38_1100p0010</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000390">
        <property type="protein sequence ID" value="TBU02926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001100">
        <property type="protein sequence ID" value="TBU11649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6L0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L6L0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0390p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1100p0010"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU02926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="189" mass="21993" checksum="D82D835CB7820813" modified="2019-07-31" version="1">MKNKIYEPSEDTFSLIEALEKDINYLRKQKNAIFIEIGCGSNYISNFIKKTLNTFIISTDINTFALQSLTRKENINSFNLIRANLLTNIIQKNISILIFNPPYLETEEDEMNHYDIRASYAGGLKGRVIIDQFISQLSKINTIYLLVIKINKPSEIISKLEQKNYKCEIIYSKKCYNETYFVIKGIKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAL8</accession>
    <name>A0A4Q9LAL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cdc37 N terminal kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0147p0030</name>
        <name evidence="3" type="ORF">CWI38_0048p0070</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000147">
        <property type="protein sequence ID" value="TBU04355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000048">
        <property type="protein sequence ID" value="TBU20586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAL8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LAL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0147p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0048p0070"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="212" mass="25307" checksum="A64808D7BCFBF9C2" modified="2019-07-31" version="1">MVIDYSKINDIQLSSDSNEEVHPNIDKKSYHRYMKALREQKKEEKRKRIIELDQMISTELSNTKKQEFLEERNKLNEEIQPRIRDVSDNVFSFGTKQKQEIEPEDLLMKLLNMQAMSEFSDIMNNHIVNIEEFEEFVLYNLSENIKIGNDEAGFYLSRIVILIKYLKEHGDRFIAVFTDKFKNQKSQELFDKECQMYYNSAKEAIIRNSNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LC25</accession>
    <name>A0A4Q9LC25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0073p0030</name>
        <name evidence="7" type="ORF">CWI38_0491p0010</name>
        <name evidence="6" type="ORF">CWI38_0565p0040</name>
        <name evidence="5" type="ORF">CWI38_0881p0020</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000073">
        <property type="protein sequence ID" value="TBU04905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000881">
        <property type="protein sequence ID" value="TBU12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000565">
        <property type="protein sequence ID" value="TBU12988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000491">
        <property type="protein sequence ID" value="TBU13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LC25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0073p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0491p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0565p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0881p0020"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="394" mass="44826" checksum="7AB26EE1FD4C3011" modified="2019-07-31" version="1">MKEYDIIIYGASGYTARFVIERLIKEQKRIALAGRSLSNINKNIISLDLKEDIEIFEVTVDNIDIITSKTKVLVNCCGPYIFTGEKIVKSCIEHRTHYLDITGETLFIERILNKYGEMAKRNGVFILNCCGFDSVPADMGFEYLKKHMNVDNFECESVMSLKNSFVNVATYQSLIYGLGNIQELRKLRRNEKKVKNKKIKKIFYNKLTQSYCVIFMGTDASVVKRSQNMLEEHDLSKKGEYSAYFEVGSLKNLILFMFYFGMIYFLSKFKFGRKILLAFPGFFSCYRIKPNGPTLSEIENASFSIVFWGKGVASNGEIIRNKLKIDGGDPGYITTATCLTHCTVVLLNMLEEKEMGIKNSLSLLEGGIFTPASVFSETDLIDRLCLKGVNFNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDT6</accession>
    <name>A0A4Q9LDT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative spore wall protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0037p0040</name>
        <name evidence="2" type="ORF">CWI38_0908p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000037">
        <property type="protein sequence ID" value="TBU05211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000908">
        <property type="protein sequence ID" value="TBU12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0037p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0908p0010"/>
    <dbReference type="OrthoDB" id="2191916at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="213" mass="24604" checksum="881616E35521610A" modified="2019-07-31" version="1">MDYKYTKVSEEHEKLEQKYRLLRDFLTVYEASCDKIMTYEHGGKTYKNVMEALEVVGERVNLQAFKVNNIYEQASLVVEKMADIHASDALNKTASDYSKALGEIGHKKTIMNGKFEDQMMELQKIKSRTAFIDKQRNITKNIRFDLEKAYKNDPDGVKIPEDLKNSFQTHLTDTEKYMREFVENKDVIGVINGCVEAQKTFHSAALEALKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE82</accession>
    <name>A0A4Q9LE82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription initiation factor IIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_2686p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002686">
        <property type="protein sequence ID" value="TBU05886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE82"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LE82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2686p0010"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU05886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="392" mass="44768" checksum="9CCC53B9B94054E6" modified="2019-07-31" version="1" fragment="single">MKCSNCGSSSIETDISKGTVYCISCGTVHEENSVVSSLNFTETSNGSSVLTGQIIKITENYTKVGTSFISTNNTYVQNTIRSICVSLGLSDDHVSSSFRWYKLSLQHNLTKGRSLLYTLSAVIYITCRQEKTPHLLIDFSVLLRIDVFKIGRTFLKITNLLNIKVPLIDPSLYLPRFVNKLKMSEKVLCLANRIVSRMKRDWIVVGRRPNNLCGASLVVAGRILDEVRGISEVARIVHVSVVTIKKRLKEMAATASANLSINEFCNLWLEKEEDPPVNKEEKIDLTINTPEELSEEKEYKLKKFEDFAEKIKPIENKENINLRKEKDLGESYNGYLEENKENINLRKEKNSMESYNGYLEENKENINLRKEKNSMEKDKEFLDENKENINPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEC5</accession>
    <name>A0A4Q9LEC5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2596p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002596">
        <property type="protein sequence ID" value="TBU06333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2596p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13267" checksum="CBA78F8609415BA9" modified="2019-07-31" version="1">MNKLEVVTIEFISQSNKIDLKRLFKNSFLLNTVTTLKIYFDEITHADIQILKSFKNLITLSISLNTIDYKTIQNIKRKDFRTTDFVLEKPIRNRRSQNVNAYLDSEFTMNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEJ7</accession>
    <name>A0A4Q9LEJ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2580p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002580">
        <property type="protein sequence ID" value="TBU06423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEJ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2580p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="615" mass="73734" checksum="7D831C4ABC696F1A" modified="2019-07-31" version="1" fragment="single">DFFLKDLLRNVMSEMLRQDSTLYFDNNLCRYHYSYIKKSLFMDIWIFFINFITFDDKSAERYIILWKNIDLTFKSLDIYCNSYNSVKKPHKTNFTIRLDNISINKTYKIFTSKFLVKTWIFFSRIANFDIIYLIFTNEETYEKAKLLWSNVTFYTRKLYIRSSTNVIELFLNKNMPIFWNKLKVLKLECNLTLIELKKLLTLCSNINKVTLKSELFDFERVRSLIDFYRLNLDKICKIFCQTYEFLNTDPEILQLMPKNLIFYSSKFQNASVDTEIPMKFIPFLHNYYHDYQYQRTAGFPTSLAILDCFMPKIIRISIEYDSPARELNNSVLLFMKYIKTIKYLFLVNIVLNKMMLIYFLETNTLVSIELVNSYFLCSLDFLSYGSMTNGNLKSLALNNLKSHIDYNFLIYLNRFKCIQSFMLIHTEIEYSLSPIRKICNFFHSFFIQENKKYLKNLEIKTDLNDYKTINILYFLSEVYDFSKLLNIVYCVYRITEIETKFFITMKKLESITLKIYHGSDCIDFEKLFNKALFSSVVLVALNVNRIREKDFKFFKLFKNLGLLSLSIEVLNYKTVSSLRKNNFKTTEINIMKPVRTNRSREINNFPDEEFGPNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF04</accession>
    <name>A0A4Q9LF04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2726p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002726">
        <property type="protein sequence ID" value="TBU05681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF04"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LF04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2726p0010"/>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="40010" checksum="74FF28B6F748876F" modified="2019-07-31" version="1" fragment="single">SSSNIKGVSKEYDIQQGVSNQYYIQQGVSNSSSNIKGVSEEYDIQQGVSNQYYIQQGVSNSSSNIKGVSEVYDIQQGVNNNTNPLNNNTNPVNNNTNPVNNNTNTLNNNLVRIINTFNYEITRLLINMFYNKNRDLHVIDELISEYSYFKGVNSNSKREMINYKISVINKYIKEKRGVINLYPRVYKGRSENIDKEGVSDRLESIDKSSNYKGVSNKDNIIEEGVRDSGNIIEGVSSKNGDYKGVSNKDNIIDEGVRDSGNIIEGVSDKNRDYKGVSNKNNIIEEGVRDSGNIIEGVSSKNGDYKGVSNKDNIIDEGVRDSGNIIEGVSDKNRDYKGVSNKNNIIDEGVRDSGNIIEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF24</accession>
    <name>A0A4Q9LF24_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2539p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="PITK01002539">
        <property type="protein sequence ID" value="TBU06609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF24"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LF24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2539p0030"/>
    <dbReference type="OrthoDB" id="2194175at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU06609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="8974" checksum="5E84F818BC1DA448" modified="2019-07-31" version="1" fragment="single">MENTKNTKTLEDLYQKKTPLEHILHRPDTYIGSIEKETQTLFVLTEQPIEPTSVDWNVEDIIINSDICEISNNSGINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF32</accession>
    <name>A0A4Q9LF32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2538p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002538">
        <property type="protein sequence ID" value="TBU06613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2538p0020"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="27492" checksum="7882AB3961B64DAE" modified="2019-07-31" version="1" fragment="single">SDKQYGVNISTNEQQGVNNNNSIQQGVNIDSSNYRGVNNDNSNYRGVNDNNITQQGVNNDSTNYRGDNIDSSNYRGVNIYTNEQQGVNIDSSNNRGVNDNNTIQQGVNGISMERFVVELKGYFSKSVEEIEKIRISVNKVVEKVDRLFERIQKGIEMGIGVDDVSISSFSGVSEGGRKRGIGGVKKRVDECVKGIIKWKNEWKDLIEVMGVLKIEKEFNLIKGIIFEVEGGIKRSEEVLSRIEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGE8</accession>
    <name>A0A4Q9LGE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2444p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002444">
        <property type="protein sequence ID" value="TBU07153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGE8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2444p0010"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="66"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU07153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="291" mass="33810" checksum="46FB4CC6C81752B8" modified="2019-07-31" version="1" fragment="single">ESVEDISTVENLSKNKNLLKQNEIKNEYKIDNKILILKDESENLKFKEYLLLNKEFTIFTDYINNFIVSIDCEMVKTSYGKEVGRVSILDNQCNVIYDKIIKPEAEIMDYLTEYSGLDKDSFEHAVSFLEMKNDLKKIIGKNTIILGHSLFNDLNVLKIYHDSLIDTSHLYKTKDNYKTSLKNLSKKYLNKEIQSKSHCSIEDAKVCLELLALKINEMKDLVENDSANINYSTQINIISIFELSNYIEKRNINIIKCSYEDLDVLNCDVLKKNDCVFMFFTQGNSHVVCCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGT7</accession>
    <name>A0A4Q9LGT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2419p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002419">
        <property type="protein sequence ID" value="TBU07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2419p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="858" mass="94519" checksum="8D7C2E3134B961F5" modified="2019-07-31" version="1" fragment="single">GSNKGDSDMDSVVEGVSDGDNKYEGVSDRDSQVEGVSNKDSSYKGVNLSTSNREGVSNKDSSYKGVNLSTGNQEGVSNKDSSYKGVNLSTSNREGVSNKDSSYKGVNLSTGNQEGVNTSNSNQQGVNDKDSHYDPITLNTGKQQGVNSLSNPNPTDNNLISNTLSNTISNTLSNSMNNPLISNSMSYSFNPNTTQHTPITNTLYSSPYCVNTLQFNYYFNTLNSLINNTPVIIVKGPLSTGKSTLVKSIITPFNHKYYNLRNNTDIDFYKEYRIIKGVKVYKPVNRLIICIDEFNTPVISNKVQESVREYLEYRSIGGVIIENVVIICIYNTSEGGYSKMEGVGYRDMLEDVSRDVVEGVSRDVVVGVSYRDMLEGVSRDVVEGVSNTSSNIKGVSNTSSNIKGVSDKCISIEGVSYSSSNIKGVSIKGTDIEGLNISTHKQHPLNNSSDKQHPLNISTHKQHPLNNSSHKQHPLNISTHKHPLNISTNKHPLNISTNEHPLTNSTNGVIDRLTSKTPSLIFHHQIDFKYITGVIIERRLNKNISKEIRGFIYNIISLKGNLLTLNRFIDNLSIESDINREIELLFKGCSYRDKGMLEGGVSNKGMLEGGVSNSSMLEGVNYKGSMLEGVSNSRDILEGGNKDMLEGSNNDILEGSREGVNYKNSIYEDMKGVSTKDILEGVKGKDGLEGVSDKDGLEGVNISTDTYHPVNTTTDTYHPVNTTTDTYHPVNTTTNTYHPVNTTTDTYHPVNTTTDTYHPVNTTTDTYHPVNTTTDTYHPVNNNTTYHPVNTTTDTYHPVNTTTDTYHPVNTTTNTYHPVNTTTDTYHPVNNNTTYHPVNTTTDTYHPVNTTTDTYHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI04</accession>
    <name>A0A4Q9LI04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2353p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002353">
        <property type="protein sequence ID" value="TBU07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI04"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LI04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2353p0010"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="78686" checksum="580F10482F554DB5" modified="2019-07-31" version="1">MEHLLQKENSLMHKLKAAESENLDLQGALLKIKDEIKTHQQKQKILNNEYIYIVEKHKEYTIIFEELKEMVVNYKEERIKREIYKITKKYNSLLKNITGISFKPTYKIFIDFSNFTSLEEQANKNNFKELEIEMKKYKEYNKQHLLMLITENIKNFLNDLKEIHNLVFYLKFLVKYELYFKRNEMSFCIPRILFSDLKKSFYFHFLTEKSTNRLDKPEWMFKHLLKKIESYFKTLQIYTKIYFEELKDENLKNNSDLQINNLFSTEKEFTKNTLNYLICKINTLICLKVRELYKLESQQKRSLVLHFSLEFLKYQNTIEEKYNLISDIPVLLELLIKVQKEFLSQQLYNTHEKTPLGWFKEYFRILKENTLFCNSYVLLDINHLRRENKSLIRNNNSQYSIDSNSSISNFSKNEITNQSYKNDSDISIPIIFNITFQFIIDSIFVYLETFISNLRYIKRQEIHLICGFFSEIENLKNKINEEETDFLIDLEKKEGFDIKKFYIDISKLSRFNNENLKLIKSLIINDIKNILKNIKNIDACSEKNLVTFSIEMNEILKEYKKYMEHSSKYVQKIVKETIDDYLVERLTIIKFRTDEFLRFRHFFGQLKESFEEKEWTTNIACKILEDIFEGRETKYQNDLFIKIKENYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIT0</accession>
    <name>A0A4Q9LIT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2306p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002306">
        <property type="protein sequence ID" value="TBU08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIT0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2306p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="9718" checksum="B0A38D2771AC3526" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPECIECENDNVLKCLVETSGSNDENLSITTIPTLRKQKVSINDRERTIEKTLECYSMSAIASMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJQ3</accession>
    <name>A0A4Q9LJQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2358p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002358">
        <property type="protein sequence ID" value="TBU07745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2358p0010"/>
    <dbReference type="OrthoDB" id="2196329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="711" mass="82929" checksum="ED734C150DF5B2F3" modified="2019-07-31" version="1">MIHNFNEILKNKKKFKNDKTLTDILRVGCTTKSIDKLSEYTITLEEYETECAPINTQNIYLSTSISYIAYSFDQKSVFIRKRNIPFIKTVIKNNENIFDLQMKEILNSDSIAYLTIIFSNKRICFYKITMENNILIFKEIYSFENETYQVIDTLDNKFYILFKNNNEYNISSLTLTEKDTFLIENILEKNKNKKVNIFLHENTLCVSLENKIHRIEKNSLLDFYGIEGQELFKMEKYVVSVAETLEDILLSLLEIKNNICSYHFEMKIQKSGKFKIFKVDNYLAVWVNSIIYWICVQECKLKIVKCTNFQFVPYSLQIIQENFNFIISLLTNSKQKTEKNENIISHLHFDFINQKEILIVDSHKTSQSNPSLNTSLNFRGQKENSIVDSHKTSHSNPSLNTSLNSPSNLNFKNNILIPMTSESNDGVKSDLIMEMTKLMDKIYLKMDEDKKEKEMKDKKRIGDWLDKMSNHFNTTLNSVIENAIRREMKGLSNSLKKTISDSFTNYEKNISSSKNRNKEDNSDIVKGIKEVIIERVLPAMEASVEEMRLQVVGEFKSLNPEDFLRERLGKLRFTESPESQLLRLLNEKKTEAASVMALEGDDSLFDYFIENIDLGMLCSLTSGCLISLLERLIGMNKNNIKPKQADFIKCSFVCLEIPDLTENELKNLEFIVACIEDFISQMVVEDKDLRLILITKKNSLYKRSSRRHRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK01</accession>
    <name>A0A4Q9LK01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2244p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002244">
        <property type="protein sequence ID" value="TBU08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2244p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="22073" checksum="41E285B5D8FFE13B" modified="2019-07-31" version="1">MLDHDYTRRHNEVEILDNGFTEIRVDTRIKTHVKIRISDPIYILNEKKNKITLIEVGITSQEKYALLANDLGLIFKCGVEIIPYEMTWDGIVTKYHNSHLKRLEIPMDLETYIYSISGLNAEESWERASMGVIMRSEMHEEPIPPLKQAKNEEDAAKNLKKIIHPKYQKEKPQSDLGEETVVVKKLQENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKG0</accession>
    <name>A0A4Q9LKG0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2229p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002229">
        <property type="protein sequence ID" value="TBU08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2229p0010"/>
    <dbReference type="OrthoDB" id="2193379at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14466" checksum="0B34143FCFA78C76" modified="2019-07-31" version="1" fragment="single">MCICIPTRIIEDSRRIPTRSSFGEIQSKFISRIERLCHTRLNAKNLFSAIHQPAILLINYHIGVLRLEPADFSKLDDAVRAVMVKNKIHLRPGCKERLYLPRKELGRGLHSVELRSDHMLLQLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMX8</accession>
    <name>A0A4Q9LMX8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2240p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002240">
        <property type="protein sequence ID" value="TBU08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMX8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2240p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="34422" checksum="C3FCA75C27F3F8B6" modified="2019-07-31" version="1">MKISLILDLIVNIVEDVILFWLRLDDNTLSFINNCDFFKKIKHMYLIDPKKCDRFKLASIAIVNLRSIILFEYMKSYSSIDISENFLRLLYRATENEIYEGNKIPFTLVETMSSKELPLESILNLDNQSIGEFKNIFFDFFSSTVYEYFIYKFYGIISQNKIVDISNLQIKNSRLKEINSLKLFLNYRIRKIKISNCDINLRILKIIFEFKFLKDLTLSEVEILIDKNEIINFKNDSIGILKIQTPNILHIQMYLHIINLIDNLEELNMDFSIFEKQPIFDEIDILPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNY3</accession>
    <name>A0A4Q9LNY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2014p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002014">
        <property type="protein sequence ID" value="TBU10109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2014p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="677" mass="80850" checksum="20E235967088E495" modified="2019-07-31" version="1" fragment="single">MKLKQRFNIYNHIHMYFKEYVMKIYEYIGLYVFQEQRSDRSKILINVQRTNTLDLLIKYTVLLTSLNLDCISCNNTKYIDFLFSEDSSCSLHSKDMNLYEYYERRMEKDSYVLCHGIHLHENNQIKCSIPDNEVEHRKLRVIRMNYFDLEKYKFTYIETLIEKSHASVIPIYLNRRIRMENFLVFKNSLVCEDFHPIFFFIKYTEFYEILGLLNHLNGYKYDNIRSIYRKIVEYGLLRPFSREILDDNLNLKSIYLKNTKKSFYILLKVLFDECNFDIEIIKNRFYILEFKTLYCDVIETFEHNSLQLYLKDIFLALFGQMLHFKLKLLLWFLDFYDVTSVSIHIKNIDEDFYMQKLGTPYLNKEYLSTLKQVRSMNKTEFVPSLINLIHFGIQGLYCPATYQNSMIDLIGQNMRKVNKIFCGELNLPDIFQPMIRSFKLILPNLKELFLNGVNLDICIATELLESNIKHIEFHYCDFGIPDCNELLNFNSTGVFLPKKISITDCYLLPEVFEIVMNSKNIYCLVLKQIKNLPECFDQEFSLQPNLYESLRILKMYEINFSEKEFNFISNFTNLQKLDIKVPDNNNEPLSLDKFNLCSLSHSLVTLKVEGFENFTLKTIETLKYLQNLYIRDSTIMEFNLFDCFESKENLIHLDLFYTTIKDKQSLNLLSKCKNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP52</accession>
    <name>A0A4Q9LP52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1955p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001955">
        <property type="protein sequence ID" value="TBU10189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP52"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1955p0010"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="118"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="380" mass="43034" checksum="EB3E1F5F8BFB094B" modified="2019-07-31" version="1" fragment="single">MNQPDEITSIDLSKHSLYEIPEVVLTKTDLNWLILSHNRLSFLPPQISHLKNLTRLALNDNRLITINPSIGSLTSLTWIDLTRNNLSSLPSSLKNLKNIHGLGLSENNFSSIPPPIFYLFSLKKFGFFSNRLTQIPPQIKNLKNLTKLDLSNNSISTLPLEFCSLTNLTWLNLTNNKIHTLPHQINNLYKLEELGLGNNTLSHIPPLTSLTKLRILPLFKNKITKISLNCISLEKLDLSDNLLEEFPYTVIYMKNIKYLNLKNNRIKKIEFTYKELYRDIETGCKEGVGGDIEGNNTLINNTSNNTPLTNTNYNTSNNTPLTNTNYNTSNNTPLTNTNYNTGNNTPLTNTNYNTSNNTPLTNTNYNTSNNTPLTNTNYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPZ2</accession>
    <name>A0A4Q9LPZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1674p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001674">
        <property type="protein sequence ID" value="TBU10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPZ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1674p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="611" mass="70878" checksum="69DACA5ABDF4354E" modified="2019-07-31" version="1">MKDTSKRDSNRCNSNRCNSNRCNSNRCNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPSYNTPTTYNTPTTYNNNIINKGRDKCYCNKCYKPFKGYHKLYDNKGYDKLYDNNGYDNNINSNTYDNNTNINTNINTNNNTNINTNTVLYDKTNIIKNNKISRNDKETVFSVFDRVSIKEGVNICKCSDKSSMEGNGEYLDNTSCYGSNRYIDNTPCCSNRYIDNTPLGNTKNNPCDNTSCYSSNRYIDNTPLGNTKNYPCDNTSCYSSNNRYIDNTPCYSSNNQCNNTPLNIYTINNHCDNTPLGNASNNQYDNTPLNIDTINNTPLPLKHTNNNINIYSPGYPLMSLPVITVQHVQLLYNKEIENTFYILKIQSGNINWYLRKSIHQLREIYNFPLFKTSDNIERRLMRNKNIVSILNNSNNYYEYGKNKNINKNNNMNSDINKNKDLNIDINKNMYENENMNNDLNNNKYDNNINTINTNNTNNTNNTINNRNTINKYLFPSFYLSDVISKYEIYMSFLVVKIRNKFYVFEPKILKNILLFVAVSLENRVYSESGNEIVIENGNENIYVYTQTYEEKEEVLGVEGDEKKEKKTRRILNVFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQV6</accession>
    <name>A0A4Q9LQV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1491p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001491">
        <property type="protein sequence ID" value="TBU10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1491p0020"/>
    <dbReference type="OrthoDB" id="2190704at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24291" checksum="5EBCE419A409784E" modified="2019-07-31" version="1" fragment="single">MSKKAYDLIYHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTIKTDAESHATNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIGLEINKEKSATNDPCCEDTATLLEGIGVYKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQW4</accession>
    <name>A0A4Q9LQW4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1498p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001498">
        <property type="protein sequence ID" value="TBU10878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1498p0020"/>
    <dbReference type="OrthoDB" id="2194145at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="27118" checksum="0339B8C128A057E6" modified="2019-07-31" version="1">MQSHDFVITTQYGSIPHFVDYKDMKCFNKTFQIYVDDFIYNGSYYLNKDVLPIKEFCSVSNNIIVTFKDKSNLLRTRRGNRKFTKDEYIEFIEKANPDFYMDFDTKKIISRGNKIFSSNFIECKNIEDFVFNLKNGGKIFSTNFINELVNNGQLITYKSEIIYISDYSSKPECSCCSNFEWDYVIHMCDIKEICALTVGMIHNFTQLDNLFKEIQKNILIIDLIKIKKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR72</accession>
    <name>A0A4Q9LR72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1565p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001565">
        <property type="protein sequence ID" value="TBU10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1565p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020792538" evidence="2">
        <location>
            <begin position="18"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="410" mass="48462" checksum="FE396DA11FBF8F9A" modified="2019-07-31" version="1">MKRILVLFTFLLPDILSIQTTEMNTTYCLRKDQIGKKFRLNNAFRMKREYNELQVIKAKLKENNELNILIKKSEINLRKIQKLLNNTNQIISDIEESKRSDSYIHKSKIEKKEILRIKNEIFRLRREKTGILGDFKRYICLKIENTEKIIFYSNYFIRNENFISKFGNQDMSFIETLRNKQKYFISEFENDSKTLNFIVTELENQNFIKNENLNQIKSSEKNKESCDEIEKNNFIERDTGNNIECCDEIEKKDIFISRDTGKNKESCDEIEKKDIINHDIPNKNMKNTQDSSGIEVSSEGNNFISEENNISSYSQPEIQYFCSTPKKNTKNFDNFILKNNFLNPKSSSIHKKTSPQHTETFSDDISFSYLNPSDSICYRNNSEDDSYGSRCYEETIVDYPFPLTNRRNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE5</accession>
    <name>A0A4Q9LRE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2034p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002034">
        <property type="protein sequence ID" value="TBU10085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2034p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="64" mass="7568" checksum="E926B8B2D2400C6E" modified="2019-07-31" version="1">MIYEVDITIESIINTIYYNEKFSCAETIYVFKKIDLKKDDGEIMPEENGERRLIDTCLRDISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRI3</accession>
    <name>A0A4Q9LRI3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2004p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002004">
        <property type="protein sequence ID" value="TBU10125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2004p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020218873" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51939" checksum="4B8D9EAEBEB8A393" modified="2019-07-31" version="1">MCDIVKIICYVFLLWIDTANMTFPLSSEDGKDKMIKILHKDEYSHDIALDYHEGEITYTHEVNDPLAVFKLINKGQGFEKKVGIEPRNAAGKRMDKNEKGNLILSSDDKQPPPLWTIKKEGEFHKLSIEDFCLAFHHDTPHTEQCKSGDPDQQFMIIFDPEKNKKAEKRDLYGPHTATKLQQGTSSNTSNSTGSSKSGSESFGSEMLDQFSNMMKHFLENPPNNINGNKTAQPVVAALGTPALVVSKTAAERIIPKDVHFTVTSTAIERSIITSTDIVTETQTSVSTIYKTSVFKETKTVDVTKTKEETITTTVAYSYIEKISTLTPEKTCKPRAVATVMSQKIEPAPLNINPACLKPTPYSKLSPDIPRHTFSDTVNYVAGYVKSNTPQLLNPYIAKTEVRTNQESSSDDILEEEVFHKFLKDFDGVEFSDNESNLPSNADVPHVHIHSKKGKKANNTLSYPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS01</accession>
    <name>A0A4Q9LS01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1744p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001744">
        <property type="protein sequence ID" value="TBU10461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1744p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="284" mass="32923" checksum="E925301CE5F508E0" modified="2019-07-31" version="1" fragment="single">MNVEPYIQSIVLKKTVETISFDTRRGLEASTGVIMRAGMYEEPKSPLKEAKRDEYGIKTENRKNNTSLISLRGTTFEKPTKKTRRVGFRRRNDSGKRAKLRMYKLVIDVHNGCINAYMYLPSEKVFVFSNDRLVLLNAPESHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVIKKTVEMISFDRRRGIESGPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS71</accession>
    <name>A0A4Q9LS71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein Mlh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1276p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001276">
        <property type="protein sequence ID" value="TBU11304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1276p0040"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="264"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="83119" checksum="60D8D6B0E00A18CB" modified="2019-07-31" version="1">MKIIQLPQEIISRISAGEVIIRPYNIIKETLENSLDSGCKNIKINISCNILDEIVISDDGCGINQSDFNLLCERHCTSKISDLEDLFNLSSFGFRGEALASISLVSDVSVLSKRKEYELGFFCEYENTKLKSIKRSASENGTKFFIKNIFKNNRIRKEYFCKRNEEIRDIYDLVVRYSIFYYRISFTLNIDNKNKNAFYSSNGYKDKYNHESLVNKDTDEYNLESLVDKDKYEYNIEGSVDKDKYEYNLEASVDKDNENEIKRKMLIDNYKLNENLKFLESEKFKIFFSLPFVNYKKYIFILFINGRLVDQKNIKSAILSVYKPYLPKNTFPFIYIEIFLEKNILDVNVHPCKKEVLFLDEEKFIKEICKEINFKIKNEEICFKKENENKKNNFGEIKEYLNYNENRNDSSKIYTDPLSLSLDEIVLEGGNETSKIYKLESLKKLKNEIEEINTGFFKNLVFVGVMDNRVLIQYTSFLLLCSFTELVEEFLYQRIIYEFGNFEEIQNIEIFLNFTDFESTGICNFNGKGEENNNFNDANMKSTKTLNLNMENSNSNHKKIKFLKSSDQVDSNLSSKKEYNSLKNKEENIYKNINISNQMIGLLEEYFSIKIYKNKIITVPKLLCPITDTKVWNSIIYRLSNLEMVNEFECLKEIIKIISKEISQCILPKKIVFNEIKRKIIGTKKSLKTFKVITQLSELYKQFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST8</accession>
    <name>A0A4Q9LST8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1663p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001663">
        <property type="protein sequence ID" value="TBU10590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1663p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020639295" evidence="2">
        <location>
            <begin position="26"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="473" mass="54784" checksum="3DBCB26B1E6BE958" modified="2019-07-31" version="1">MYFQKFIPNKNFILIVSLLLTCKSSDNLRSGKRSFSEISKDQTSAVSVKKGSKTSDVKRLPVSPKHRNSSTNKTSSDNVGANINDKRRHTKGDSPKKQGRINSRSARTEKIVNIPLPREDQNFGFTLAESGINHASNNISKVINRTNNVRMYNTSISRPSKPSSVETPGFINVIYAHCVQRRSSNIISSIFEKSGRIYEISENEFLEKYFTILEELAPIEDYIIKFNPQQKKIFEDLFEKNKKHIDLSISEDSVLLEIPIFISINKIIEEVINSGTSNIKNHVTFFFYLKLIEAFIKEIHKRINFIFNRSADIRKKNIHLDKEFNTALYNGLLLIIRTTELRFSIHSPILKKYYKAFLFACEFFRSMTNTNVAYVDAKITQDDFTVFLIDVILYIEESDINEICLLILSSFEFNDEAYANLQKRFDIVSKKNSHPQEKNRTTLIHLLEDTYKYFHDFALPQKISEKNQTEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC9</accession>
    <name>A0A4Q9LTC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1223p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001223">
        <property type="protein sequence ID" value="TBU11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1223p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="791" mass="95747" checksum="C2768ACA134DD837" modified="2019-07-31" version="1">MGKPKDFDIKKLKISENIIEEEFDSEISDELLSYSEIEKNIKNKRQKKHKNANKTETIIPPVSEDLKNVDWSKIALDLDKMKSKATWKKDKKELKFIPINLENDKIEKMKIELIRNPDNNFLRIQLSKLLDSYNSEKILLDGIANSKTKCDKLWIELLNSFYTKERALEALKNIDTNKEEIYIKLYENENDISYIKEGLKYNQKSVILWNLLIEYQESITSKFGLLSYAIEMTRNDFFIDKLVILYEKYLKNEEFNESKNFHESKNFDQIENVLEKNDQLFNFSKIYNFLKENKHFNENFSIFTLNNAKDKEMFRNVRKELLERNLDTIFKVLKKVKYRIYIPPSILNKEWVNNFIKNIEIIYFTDLPFYLQSFFISFANSQFLDENLFFECYNIFSKFNCDTNFITTFFNKITHRYDQLKTYSDCNYIYDLLYCKEIWKILQIQVLYEKDLKLLKNLIDLFSENISFYRKQREKFTVALSIIYFKLGDYYKAFNTLKKIKNTIFKFVILSFIDFNKTIKDLKNNLTGYKCYLLYVDLLKIQNIDIQFEYEEGIKLFPTNINIKLEYLRYLRKYKFDFNQIQLKIENFLIEDRNNEFLLFEKYLLYKKNFVLNFCIQNIEVESENANFVGNIKKYKINDEFKHKNNCVLPISILYSAKSILKKSEIINSEIIFLERKQIEDKNSMFYGLNVFRNTIYLKCNYESFCEKCKQQLYNILIAEVFKNSDNLILLWFLFKETFFEKDIEKYSYFIDEDKGFYYKKAIRSLKYKTFSEKMNYGFNLIEEDFLFTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH6</accession>
    <name>A0A4Q9LTH6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1197p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001197">
        <property type="protein sequence ID" value="TBU11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1197p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17161" checksum="68F864B7D34C7E87" modified="2019-07-31" version="1">MREEPIHMMRRKNFFEPLFENEKFENDKMNITFNLPEGVDPNNVEIKHEKNAYHMKYKTETKDEKDGVSFSSSSYGYFSRSFPFEIKNPHAEVKENKLFFSFDRGEDTSGLKSIPIKNGNSKEKIVTNKKETDSNASCSSGKCQHCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK4</accession>
    <name>A0A4Q9LTK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1020p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001020">
        <property type="protein sequence ID" value="TBU11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1020p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="25925" checksum="AF7D25DBC1684E05" modified="2019-07-31" version="1">MKSTPSDLKSRCFSFIIDFDEVHIPIINTSEASNCIFHKCIPPTFLNILKSLFYAFSPRILYLDFVLDIKYWLCIFIVQLISEVGKEKFLSILRTTFSSNEPDLQKELKSLFTEVPNLPLFCEEIKTYLELLKGMIKSSTYVAFYIFKIEPHCFNLIFMESITEFEFKEEILNLKDAEEFEAKIQENIMRCFSFFFKYSLSKYFKTEGLIMKKFIFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK9</accession>
    <name>A0A4Q9LTK9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0964p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000964">
        <property type="protein sequence ID" value="TBU11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTK9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0964p0040"/>
    <dbReference type="OrthoDB" id="2189658at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38784" checksum="E91F56AD84899CB3" modified="2019-07-31" version="1">MNTENILEDFKKRLKKISYSMCKNRLKEENLMKKDVELITDCRNQTIESLKRVSLQSIVNINDRPITTLKIFNDRIYYGTRDGKLCDIGLNDNTNISKHQISEHPISCIVQKEINFLITDFGGNIYSFENFEAKLLKNVESRILNFNFQKECNFFCYNDENASFHILDASKLVNLAKVDTNNSIYNLDLHPDGNLLMVNHMNSDIYDLRCLDVIMRYGKNVMSGAFMKNGFMINIGTKEGVLSCYDIRNIKNVGNILSHKSSILNVTNYDFFTVSYSADNDLNFSSVFMSQIFNKFDFDSNITGFDKSEEYLAIGFTNKTIKIFRFYFLQIYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT6</accession>
    <name>A0A4Q9LTT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1131p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001131">
        <property type="protein sequence ID" value="TBU11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1131p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="123" mass="14417" checksum="FF22343B722B3859" modified="2019-07-31" version="1">MVKKILKLVKESTNSFVFGFLIEMVKKRKIIKNRSIKYVTTRWTHNGFDFASYTFISGVSRIFIDKIGTLRYPIFNVFFCSFISNTVLNLKYGFVYATKKGIYGSFYAIFIDKFSRKIKNALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU04</accession>
    <name>A0A4Q9LU04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0942p0010</name>
        <name evidence="2" type="ORF">CWI38_1013p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001013">
        <property type="protein sequence ID" value="TBU11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000942">
        <property type="protein sequence ID" value="TBU12004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0942p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1013p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="418" mass="49163" checksum="E14C65C93804F4BE" modified="2019-07-31" version="1">MDKTEAMRCLKASIQMYMNIQKRTKLLRAALNQIETHEWNQQMNVKLTNEQKLLVSQKKNVTLLLTEMEDLSKLDMDEEYLFKGKMTSTDMLNECIAALSDSLDDFKVEFSEEYRAIHLKDDDYINGKIEQKSSEKEEIPFVIDGLTTKLNLNEYSPIESVKNVMDKLNDLCLSDEEPEKSSEGHFETKEEKKTIQKQDSFKSEEKKIQKNKKAFIKQNKIPLKETDSTKVNNALKQFEKNLETQKTSNLQLNSHEKSSSSVTAKKNVTDKFRNDYRENKRDTNYENTKNKKILKPDFENPNFKKQYDNKGYQYRRRPSNPNNEVLERKKSFDEHSTSFGNNSSRNIGNYENKNEFYPRNNRSNRNFYYKKNFNTDIPSKNYKTSGRYNNSSTNISTNDDTKSPKNTLFDLKTEKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU92</accession>
    <name>A0A4Q9LU92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1341p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001341">
        <property type="protein sequence ID" value="TBU11175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1341p0010"/>
    <dbReference type="OrthoDB" id="410404at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19495" checksum="89C2DC0E180B3E7D" modified="2019-07-31" version="1">MLEYVAVPTPIVIIYSSLHELEQESYTPEIKKELANQKYNTKLLSREMFSPVNDTRRAFIPQTNSCRSKTGDIISDTQGDICSYEDIVPSYEEVNKAVEKPKNIKAAETNGISTELIKNTHNSDALKNAAGSFLMYLSESWVVKKTDEQRLAVFKRKVPRRIYGPKEENCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUP0</accession>
    <name>A0A4Q9LUP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0964p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000964">
        <property type="protein sequence ID" value="TBU11956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0964p0020"/>
    <dbReference type="OrthoDB" id="10656884at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="19036" checksum="F24C0431FA73159E" modified="2019-07-31" version="1">MVEAGKPNENEGSSGKTNETKRSPIQNLCFESNGDDHKATILLSKKVYIDNIYLMRNENPENINGYVVDKVIKKKDYKFEGNDIEVNLSELDLDKDNKIAYSFKIDESGGSFQSEAFKYDKKDNKFKLVREIKGGFLGFSWTTILYVGLVVIGVLICLFILMKIMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUQ8</accession>
    <name>A0A4Q9LUQ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1251p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001251">
        <property type="protein sequence ID" value="TBU11355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUQ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUQ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1251p0010"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF4">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="11">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="458" mass="53213" checksum="141E3D17A4E95A29" modified="2019-07-31" version="1" fragment="single">MTMENNLEEKEITTKLKLINAFTKNKDIFTPSRGNLIRWYICGPTVYDSPHLGHARTYVSFDIVRRVLENYFGYQVTYVMNITDIDDKIINKAKETKMEVSEACKIITKKYETEFFEAMDNLNVQRPTFTTRVTNYVEKIVTFIEKLMEKGFAYESEGSVYFDLVKYRENFKHPNFVNESAINEETEELENIYKKKNKIDFVLWKKSKEGEPVYNSPWGEGRPGWHIECSAMASDLFKDGLDIHSGGCDLAFPHHENEIAQSQAFLNSNLWCPYFLHSGHLSIDGLKMSKSLKNFITVEESLKNFTPRQLRILFLNTNWWAPMTYKLESMEYSKKIEAKLMNFISISDSFIKNSEIEDNFKNVTDQDSMILEILENTKISIHEAFCDSINTFKVLTAILNLITVIHQKIENLSIRVIYVAKQYVVSILNLLGVVEEKKGFDSLDQDVLKLVCDFRANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR4</accession>
    <name>A0A4Q9LUR4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0770p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000770">
        <property type="protein sequence ID" value="TBU12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUR4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0770p0030"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="4">
        <location>
            <begin position="3"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="62963" checksum="90CB5D0A68F9914B" modified="2019-07-31" version="1">MDYEHLLSQDPNNTALQLSYFNHLFSSSNFTLLESLFLKYLPNNYNIDIIYLYIKYTEYLVKSNKREIDLSAVYEYALSRFSNHYYSQDLHKNYIEYLQKNNPLKVRTAFKNALIVPHSELNTLFKDYEEYENGLNKLTAKKLVSDILPLYQHAHRQYTILSSIIDFEEHKIQNINLQILFLLTDFELKNPLNLPSTELDQRLDMFFNVMIDRFYYTDQPYFLYSEYLISKNKTDEASKIIFKGIHENKKSLFLYLYYSKITTIDVPNIYQNLIAEYSNEFNINKENQSRNFKNGSIMLKKPIYYNNNFDLIVIHYLSFVVRNNGITAFRKLFNSLKDKNLGPYTYIFAGLTEYYTTQNLEISQGIFNLALERFPDCRIVSYEYFNLLNMAGKNDSVFERITKSDILYKNVISFENKWGSNFREILERYLTSELLDCCCYGKSEKFSDSQRCASRAYTLDNYSELDSPTISYKRYKAVLESFNFLDMRIYSKDPINEIQTQIPSLPDKNNIFKIIDINEVIEILKKVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ0</accession>
    <name>A0A4Q9LUZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0305p0040</name>
        <name evidence="4" type="ORF">CWI38_0738p0020</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000738">
        <property type="protein sequence ID" value="TBU12483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000305">
        <property type="protein sequence ID" value="TBU15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0305p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0738p0020"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="628" mass="71650" checksum="BFCC2F2B934DEC64" modified="2019-07-31" version="1">MKKQNTNLQYIKKTNDFYSHVAYDPDIKATKEGSETLLELFEFVCRSNPEKDFIGFIENEKLYWLTYKEILERTTKLSRFLKMLVSPKETIGIYSVNRPEWIITEQAIYMVNCVNCPLYSTFGIESLKHILNETEMKVCLMSGLKAISFYKEVLQNTKTHLTDIICYDELDSQICKNYKSKNIRIHFLEDILNEDFVDTNLKDYGRPGGEDLATICYTSGTSGCPKGVLQTHRNFISTVSSFTMSGATDSIFSLNDSDVYISYLPLAHVMERIIFSVLMHVGSKIAFYNGNPKRLQTDMKIIKPTFFAGVPRVFDVFKEKIMEKINEKNFFLRFIFNLALRYKIYQVRKGNFICKFLDKYIFNKVKEEFGGKIRACLSGSAPLSPSVCEFLQAVLSCPIIEGYGQTEAIGANILKPTTCPDVGVVGIPFPVNAVKLIPWDKYPGGTEGEILLKGPNITKGYYKKPDLTEETFTKDGWLRTGDIGSYSNGNFKIIGRRKEIFKTSLGEYIIPEKVETALKGGILNDILIVGREFCNYIIGLVVCTDCTIDLEEIYKKTIEMGNKKFLEGGLTRFEIPSKIIVLRKEFDTFGEFVTPTGKKKRSLIEKYFEEDIDNCFNGTYSFILSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV12</accession>
    <name>A0A4Q9LV12_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0851p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000851">
        <property type="protein sequence ID" value="TBU12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0851p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11217" checksum="DABE38F646F3055F" modified="2019-07-31" version="1">MNLNSDTNVVFYIVTNQEPNKCSNAKKKKLNVHAKKQEIYAENMNIEATLQFYTENISREYNEYRIKGIEKFGIKFDIFEIDGKLSNGNSNIEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC2</accession>
    <name>A0A4Q9LVC2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0802p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000802">
        <property type="protein sequence ID" value="TBU12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0802p0020"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="24330" checksum="1C603EC5644BC1E3" modified="2019-07-31" version="1">MVSNNDRERIILKTLEGHSISSIASMYRINYQTVNSIVKRYGKIGLVFVEKRSGDMPPKSTLEIKECLPTYVNSECIKTLHELVEWVKSKFNVDVSTRTIYRALREFHYTLKHEHWCLTIEIHLQQLSLEKFATNFRDRGRNMRGESVCLSKYGMIYHKIHERSVSGEDFNFSMKKLKKIEITSFQIKYLLPYSYLLNTVENVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK1</accession>
    <name>A0A4Q9LVK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0768p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000768">
        <property type="protein sequence ID" value="TBU12407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0768p0030"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="625"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="862" mass="97213" checksum="B90D2418D9A05DDF" modified="2019-07-31" version="1" fragment="single">TNYKGDNDKGSNYKGDSNKDKEQDLVNNSTNTLHPSIPNNTTVNNSIINIFNSLNDKTFLYKIGKTRIFFDYKLLGLLENKRIEYYKKHKIIVKGVILYLYLEGVKMCYNRLLVRVKGDIERRLNVRSMDVYDISNRCYSEHADNKGGVGSMDNRVEESSRDKGVLNNSKDKGVLNNSKDKGVLNNSTVSSSDKGVLNNSRDKGVLNNCTVSSSDKGVLNNSTVSSNYKGVLNNSTISSSDKGMLNNSNQETLNTKYNPALDKLDFNILQETHNNSTDSVNIIKNITPFNHTPINNTSSSEINILKHKLKKYENFYKIPCKNCRALEVKYKAQTEALKDRNNLLIENESIKKELNRLKKEMNRNSVTGSDISSTYKGCNGNTTSNNTSTTLTNNTISTISSITNTTSFDQERRIFLSKIQKLEEELKRLKTTPETPKIHFSNPYEIIGCLLEAFIQHCPTFTTDPLPKEEALSLAHTLYQSVLLLMNVRKDPSISELIGVIVDSVRDRIPLISNDIYKVCFILSNVIELKCIINNEILKHSKEGFSSKESSGGLSNSSKDSLINNTSGSNSNTNTSYTSSSNSYVSNTSYSSNSTNPSTSTNTSYTNPSTNTYTKTPYFIPFCSDGVICELEEVIEVLFTCMVNYYRRVLMDYIPYSIIEYQGLKEFKCKEGFFNGWGGGGVSINKLVGVLDWMYGMLIFYCLPLNFCMEGVNYILKVINSVSFNALLVHKGVLCLNRGIQINNNLNFIEKFCRDIEYSEGVLNMGHIKSVVKLINYVNAGAKLETIMDECSFLNVLQVKILFSKFKKEECCYEVKVADFSMEKFIREPKVYVPGVKEYSYHTFSVPRFLPSKYISSILGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVT0</accession>
    <name>A0A4Q9LVT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF933 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0613p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000613">
        <property type="protein sequence ID" value="TBU12823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVT0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0613p0010"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="13"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="476" mass="53363" checksum="B8728932CB69F129" modified="2019-07-31" version="1">MQKFSRPTKSHNLSMGIVGMPNVGKSTLFNLLTNSSVQAHNYPFCTIDPTDGRVSIPDPRLSHLSNIYTPKNTIPSYLNVTDIAGLVKGASTGLGLGNAFLDNIRTTDGIFHVVRCFEDNSVVHYDTTVDPTRDIITINDELRFKDLQLVNKILEKSIKNRNNLSKDKRVLFEHNTLVKIKDILEVCWLTECLNKGENDIDKGKSNISHKDINIGIIKDNTATNNTTSNINTINNNLIPSNFALSNDEVLFISTLNLLTTKPVVYLANISNEDYKNKKINKYLKSILHVKPIIFSSEGEGTKVFIDKMVRMGCSVLDLITYFTVGKDEVRSWKIRNKTLLPQAGGVIHTDFEKYFVAAEVFNYKDLHEKKGKCYTKGKMYVVEDGDIIHFKFNAPKGGGGSKKGYGVLMILIINNGFRKTGVNKLVYIIRKIALTNLNYCGMPPTAVKDCINICGKCKNWALKRIENTNSHLINFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX5</accession>
    <name>A0A4Q9LVX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1045p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001045">
        <property type="protein sequence ID" value="TBU11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1045p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020207312" evidence="1">
        <location>
            <begin position="18"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="578" mass="69270" checksum="E8D91C56E695EC14" modified="2019-07-31" version="1">MLLGFILLLLFGLSSNASFIESEDENIDVETIENTDISEWKPMCIPNTENTMARFDGSFASKKSIKDIHSRRLKNDMPLREKIKFRLDEVLKDFELHYEYLTISNIERYTYILSKYEYQVYCSFEVLKKNLYENKKTTAFSFKYMHEEILTDFVDVENLYLNIKKCSILINKIYRFFLLENEQFGSLESIYMEQDNQNPDFILTLFTDLEFANIICQMNKEVEKLNSGENFEHDYKKLKLEYRDCEAKICVYSVNPVSPLFCLPDWDRLYSSNFITNWKKTILEILEKKNNYIFFILPEFISFEFRLKEEIDSIRLKNGDYFKAILNLKLLLNNPIVDKIQQRYNNQESKNEDKFNHHEERRWYLKKKQHLKKCFMKVIKIFVLSIEHNLIYSLMYTLEKTIYYGFVGNRLGDNSLFYYHKLNILNDVIFLMNENLIKSIFLNLDAMMICILHKLPSVAKKKRYTDNFFQNFDETVKRSILHLYIRLSEYIIKIGTIKKICGGKYEFIVFQFEAIKIFLEGSEETCILNSKKSGYEKEFKIDELLQFSACCLQQILGLSFHRTCFHNLRNWFKGFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW37</accession>
    <name>A0A4Q9LW37_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0935p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000935">
        <property type="protein sequence ID" value="TBU12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0935p0040"/>
    <dbReference type="OrthoDB" id="2189693at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="194" mass="22797" checksum="F4E3EF5A8882AF6C" modified="2019-07-31" version="1">MFDEALFKNLLNETSSLIKNLEESKDIEMEDRISCNVLALKVLANDIEDEDLKSSVLKKIESIYNTGIYMSDNINNEYQIKGDKETKIREKSKNDKEMANIEIRETDELRNRLETDLLNYSKLLNQKVKNFKTKIDEDTEVLQNTENVFSKNLFGVEDGVSRLRKQVMGGFSPLRMLFLSIFIFLLMYFFIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE7</accession>
    <name>A0A4Q9LWE7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0963p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000963">
        <property type="protein sequence ID" value="TBU11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0963p0010"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="26054" checksum="EC27F7A4FD12C57B" modified="2019-07-31" version="1">MEELKKIPRITRIILTMSILIPVLFTMSPFLSEYLYFDAEYLKRLQIWRLITGIFVSTFDINLVFILLTRYQILKFIEMSKLQIDAISHEIELTFFILSFSFTLFLANFISELGSFNQCINMALVNYMCRLCGTDNMISFFGFSISPIYFPYFYGFYEYIISKGTSKFYYGLIHSVSYIYLRKKLFKIPQCYINFYTYILSRINCPKGFKGVGRKIGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH9</accession>
    <name>A0A4Q9LWH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0533p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000533">
        <property type="protein sequence ID" value="TBU13093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0533p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19742" checksum="216833F02BAD20AD" modified="2019-07-31" version="1">MEMDWYPSLLLITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIAYIQSLVLKKTVETISFDRRRGLESGLNAEESWKRASMGVIMRSEMHEEPIPPLKEAKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN0</accession>
    <name>A0A4Q9LWN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0516p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000516">
        <property type="protein sequence ID" value="TBU13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0516p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="804" mass="95398" checksum="8289DBAADB3EFC01" modified="2019-07-31" version="1">MVFLKEKRDFLKKIKQEQTINTFQILIKYTLLLTAINLDCISCNNTKYIDFLFSEDSSCSLHSKDMNLYEYYERRMKNDLYVLCHGIHLYENNQIKCSMPDNEVEHRKLRVIRMNYFDLEKYKFTYIETLIEKSHASVIPIYLNRRIRMENFLVFKNSLVCEDFHPIFFFIKYTEFYEILGLLNHLNGYKYDNIRSIYRKIVEYGLLRPFSREILDDNLNLKFIYLKNTKKSFYILLKVLFDECDFDIEIIKNRFYILEFKTLYCDVIETFEHNSLQLYLKDIFLCRLCKAGSSILKVFFWFLDFYDISSILIYGNENDMKWYMERLGPPYYNQQYLKDLEKLRNQSESESVSFLGNSNYLCLPVYHSGVTNQNIRIDAFNQKMGKIERIILEDLIIMDIYQPIVESFKTILPNVNDLFLCNVEIYFCILSNLIKSDIEYIQFHFCKFIVPYCYDLKNYNYLSPGIPKKISLSTLNILPEVFDVLIHSKNIYCLILQYVNNISECFNKKLGLKSNIYESLVVLKMSEICFSEIECKFISNFSNLQKLTLKYPENGIDSLYLDSLNLCLLSHSLITLKFQGFKNLTLRILEPLKSLQYLYIRNCAIVDFSFSDYSSLKQNLIHLDLSHTKIKDKQNLNLLSNCLNLCELKLSYCGLKECDFFFLKSVNLQKTITEFHLNGNETNSKVLLEFFEYKNIHTLVISLKKTPHSTFSVLKNCKFTTNLKFLFLYDAILNDQDMKTIFSFTELECLTLEDCKIIEESSKVLLFLPQLPSLKTFEIIDLIITDYDKNILLGFYETAILDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR9</accession>
    <name>A0A4Q9LWR9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0523p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000523">
        <property type="protein sequence ID" value="TBU13124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0523p0030"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="4">
        <location>
            <begin position="3"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="63031" checksum="2323819E1956758B" modified="2019-07-31" version="1">MDYEHLLSQDPNNTALQLSYFNHLFSSSNFTLLESLFLKYLPNNYNIDIIYLYIKYTEYLVKSNKREIDLSAVYEYALSRFSNHYYSQDLHKNYIEYLQKNNPLKVRTAFKNALIVPHSELNTLFKDYEEYENGLNKLTAKKLVSDILPLYQHAHRQYTILSSIIDFEEHKIQNINLQILFQLTDFELKNPLNLPSTELDQRLDMFFNVMIDRFYYTDQPYFLYSEYLISKNKTDEASKIIFKGIHENKKSIFLYLYYSKITTIDVPNIYQNLIAEYSNEFNINKENQSRNFKNGSIMLNKPIYYNNNFDLIVIHYLSFVVRNNGITAFRKLFNSLKDKNLGPYTYIFAGLTEYYTTQNLEISQGIFNLALERFPDCRIVSYEYFNLLNMAGKNDSVFERITKSDILYKNVISFENKWGSNFREILERYLTSELLDCSCYGKSERFSDSKRCASRAYTLDNYSELDSPTISYKRYKAVLESFNFLDMRIYSKDPINEIQRQIPSLPDKNNIFKIIDINEVIEILKKVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ3</accession>
    <name>A0A4Q9LWZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0609p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000609">
        <property type="protein sequence ID" value="TBU12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0609p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020667698" evidence="1">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="183" mass="21190" checksum="D32F9BF04CE28096" modified="2019-07-31" version="1">MKAVRHQNTIPHSFSLSFTLPFLLFLLQLHNSTPLLFSEGVYIKMHNTEDYIYLHQGYPIKLGSKATATKFKLLPVIGSITDTKIAIFNHPETVIEFDEPKHILPNHVDIHTSQDFMIVRDHTGAERIVSGDMCVEYDINTGYFFKNTCQNIQTQLFDFINDVLYESRGIFKRQFGNRFAIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX19</accession>
    <name>A0A4Q9LX19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory subunit of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0592p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000592">
        <property type="protein sequence ID" value="TBU12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX19"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0592p0030"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="RPN1 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="5">
        <location>
            <begin position="906"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="950" mass="104957" checksum="ADF7B9523C552513" modified="2019-07-31" version="1">MEKQDEIELILTRLSEASPQIQTTSLQCLQNLITTSPIVFNHPSLKQTLTDILPSLDTQNQKYLSDLLSFLYVVEENDRSLHYRLNGGVVPIYTCNHQYVVKLLHSILEISPRTSVEDIPVNELREIAKHYNIIMSSSTSSSTSNTSSSSVSLPPPSSLPPSSSLPLNNLSNNLLILAVECISFLFSHNSECEGIDFLLELNLLFLVTEYINSHNFQRIRLYLSEMSYYIPIGHELISIYTEHKCYVDLLLLHLKSNDISHCIHVFNMDMPYKTRLQCAFILGRLGLGDRLLGCVNNTPLITAALSNTLLSKTLNFVFEDLEITPPKHITEFIKGTNLLKQDKDLALKSFVSVCISNGLVHMGYTRDLLFFPGEEDSHEHQIEAGLLKSDRTELISLLGSMGLIYSFTGKGIEIFNDAIFNGGPFRKMGGILGMAIAQGKLYDESHTLMAIVNDLESTESFIEKLVILLSINIVYCNTNNEMAAEFIVDFISCTDSSEVIGYGIFVLGSVKCGVGDTSIFVIMRELLSKIDVSNGFYSYALLGMGLLFLGCGGEILADQFGLSISEIQNQAVISNCGDIEEEIKSEESENKYFGSKSENKSGNRSGNKSENKSGNKFENKSGNNKDNNKPNNKDNKDTKHKDNNDENILHSSDNFIEGENSFSFLPRPVQVIIKGCVFVGTGNTTLIESILSECISCMDDKILIACSFISIALISMGDDLCVKMVFRLLTSSCLLESGYVKQMVNICLALLFPSTCDLDVIDFIGKQIHSPDEDIMLSAIGSLGVIGSGSNNSKISNLYESLYSYHGKNLKVIFLVKVVQGLLHLGKGIYGLKCWGYDKRVLFKRGIIGVLSYLWLFIGDGSLGVKYPFMLYNIVTGVSPKYVVTVDEEGNYLKGGVKVGNDVNVVGVAGHPRRICGVQVHNLPVILGEGERAEVEDCGDVVYVEDVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE0</accession>
    <name>A0A4Q9LXE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0768p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000768">
        <property type="protein sequence ID" value="TBU12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0768p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="94313" checksum="19FD7177ADCD97F3" modified="2019-07-31" version="1">MSIQIKNLHRSKRTAAIFILLATHVLTSILTTVNFYIINEENRVKNYINSESTMDIMFKNEKIEYFDEINRITILKDNVLRQESKGGITKYYESNTVTLRYTDTNLLNSTLLKSLYISEKNIIRVFLKDVSTSNFLLFLKLIDNPDLLINQIDIKTFIDILTIITILDIKKSKQRNKIIKELLRNLVYGINIKSFNLENICCLDYTNNLVKRSIFRDLLIYFLEFVYFNEKRTRLHIVIKRSCDVIYKKERGPLYEKSIKKSQKNKIYLKLKDLDVKKLVKIVTSYNLKNIWIFLFKIIRLDLLFFNFNFTETFEELIKLLSDVRFNSENFYLFCRKNASELLLKMENHIFLKNLKVLKFNFNFDLNELKQILFLYQKVIRCKINTNEINFETFAFLIDYCLKNPFISIKLETFFYKSDNTDLNVLKFMTKNLLFFPFLIKAGKYLTGVSEDQIPFISTYYSYLYYDISNYSKNFMFLDFSNTRSIKISTNNPASPPLKIDDIVLITLKRCKFLKYFSAKNIIISDELLIYILESLTLLSVEIKNLVYVFNHDLFSKIDTLNLNLKVFGLFSPRSCIKSNFMIYLAKFRSISHIKIENTEIFREVWSLEYFWQKIGFFSKRNLERIFLEHLEIKYPIKSPYMGNCMYFMSKIYDFVNLRSIFLYSYILTEVDYIFFNKMNKLEVVTIEFISQSNKIDLKRLFKNSFLLNTVTTLKIYFDEITHADIQILKSFKNLITLSISLNTIDYKTIQNIKRKDFRTTDFVLEKPIRNRRSQNVNAYLDSEFTMNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXV5</accession>
    <name>A0A4Q9LXV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0374p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000374">
        <property type="protein sequence ID" value="TBU13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXV5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0374p0010"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="308" mass="36627" checksum="89D6597B0EB8FA2A" modified="2019-07-31" version="1">MINYNKETNYNKTYSNEKLEKSNESININNYNTIPFKIALLAATFYYLKEFDKSILLFNFIQNNFPLNLDFYDLFSNILYIKNDIKQLASLTTKCVELNPERPETMCVIANYYSLKGNHENAIEYFKKAITFSPTFTSVYTLIGHEYMELKEYNMAIYSYNKALKYNKTDYRAWYGLGKVYLSLSLKEYSSYFYIKASELKPDDSYIWLCLGQVKLLCNSIEESVSCFLKATTLGDIDGYLMIADLYKNEKRYYEAVIYYEKYVDECKERKEDIYKICVFLCEYYNEIGNIKKVEFYTKMMDEYEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY72</accession>
    <name>A0A4Q9LY72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0314p0020</name>
        <name evidence="1" type="ORF">CWI38_0335p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000335">
        <property type="protein sequence ID" value="TBU13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000314">
        <property type="protein sequence ID" value="TBU15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0314p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0335p0020"/>
    <dbReference type="OrthoDB" id="2191347at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="481" mass="55455" checksum="511A3FBC3668788F" modified="2019-07-31" version="1">MDFDILKFNITSKLQEIIDLTPKIIENNKKINFYYLKDVYNSFKSIFKVTQLSLTEFYKVLITLPEMSVTSNQDTSFSIVCYKKDYNREKIEQILNPKSVLKNNEEDFSDSSDFFKNGGKIEIIEPKNKFIKNRNKNLNLNSQFSNKKPIQQIKNQVSGNQPNSYPDILGKILDVFKYGIVIQTSSISNEMCKMHGQMFNYKNSPCQVGRHPHGNLSKYFSCCKNSFTILNLKSSYIKRIDQDADSLIKKRKSFHLKDVSFTEENSKFMIFHLECLIVNIFCCKTTLSLDDLQEVFKNVYGFTLESVCGQRVEIFINQILSSPNLYVTKSERGVSVTCIPTFNEEYKDFGNSEYFLKVQEIEQSISLGNSVVTSVSLQIEEKPTKQNTMISQPSRDTGISKKDLMAHKKINVPVSSLSIFPKYKKFTEMLNFADKNVPRSLQIRKFVCDSATLYKDMETSGVSDAWVYLYESLALDDKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS6</accession>
    <name>A0A4Q9LYS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0429p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000429">
        <property type="protein sequence ID" value="TBU13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0429p0020"/>
    <dbReference type="OrthoDB" id="2196166at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="114"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="35684" checksum="9635E7D4E4492575" modified="2019-07-31" version="1">MISFIIKKANEAFESLTGMKFTKCSRSPFDINTNDENQTNQSEEIIPKKIEYMVPFNVKKSYSFFIKYGNLTRSERIYLSEYCFINLNNISRCISVTKIIFIVKGFFTKRKNFISLKRKINPFVFELIDYLKKDGTDKIGIFRIPGKSNIYNQISKDLGEGKTYHIESYDINTNASILKAYIREILDGLIPIEVCKALFEITNQNDQEKISKVREVLPFIFLEDYRLLIIKIIDLLKTIDSHSCINKMTMSNLLIIFTPTFFPKSVTNSYEILALEGKILEILTYLDFENISLVLLLEAKKYFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW1</accession>
    <name>A0A4Q9LYW1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0262p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000262">
        <property type="protein sequence ID" value="TBU17943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYW1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0262p0040"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="18118" checksum="BB82D1A7E0D94EB2" modified="2019-07-31" version="1">MGSIQNYFEIFKIKPSFDIQPTILQSKYHELCKKYHPDISSDFDIKDGDLNIAIINNAYKTLLNDYKRAIYLYKLNGNHLNKNLSTDFLNEILFTNETIDMTTNIDVLNKLKEITVLKINECKNKYNDSNSLIKWKYYDRMLKNISNKIEMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ05</accession>
    <name>A0A4Q9LZ05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0249p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000249">
        <property type="protein sequence ID" value="TBU18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ05"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0249p0020"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="462" mass="54127" checksum="08725D51207EDC7A" modified="2019-07-31" version="1">MHGKESNLRRVSDKFLQANEDISIYMETGAVKVIRSGKLLGRGGYAEVYEGYCIQDKKMYALKFSSTENASYLKKEAEIYKRIGLHGSIIRFHGYGEYKDFFVLLLELGSGSLSNFYKFHILNDYQIAAILKQLIDVLTFIHNKGIIYNDLKGNNILINEDLEIKIFDFGLSCNENSLVELFKNDGKKRDEDYSYISPEIRNCKFYTNRSDLWSLGALLWTLYSRENFLGDLYSENLSFLSANMLSLLLQVNPLSRAPCGLLIFHGFFDYLYNFLIDISNLPDFYLNISDNIKLQKIKNEFIYEEYGTSFHLIFPPNNYQIRKNLERKIIAFQQQKYNKFYENTNYSFIYSKYLSCLVGFSKEYLYSIMDLDYNSLRQIMNLKKIAINYMKGNLYKYNVNLSAIKNNIKILDKQNVFRISKPQENFSPRSISRNENSVDMKSRNEKMLSKRMKANTSTPFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ56</accession>
    <name>A0A4Q9LZ56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0241p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000241">
        <property type="protein sequence ID" value="TBU18431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ56"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0241p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020549267" evidence="3">
        <location>
            <begin position="21"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="708" mass="82624" checksum="B504A454492B8121" modified="2019-07-31" version="1">MFFNLFVCLEILHCYTGLNGDPTIVENCCIEVDLVPQTNHEISGIFQRIDFFCLPNEVSELTSVASYYIEYVKKHTNSIHHKFLTRFVCLVVFFIRPKDKTDPNKYQTELLFNILSFAKLYEYSRCNKEMNDIEKARIVSLFKTGMKNIFYIHESVEKRPDKIEILCPLTIKNIETSCDLNSDLDFQILKNTYVLGERNIGSNLSNYLKYGSFEQIYSLYLYLKLDFLLRNWEDLNDEVIIFPFHQISFNGDFFKKLLALNLSLTKDLYLKLDQVKYREVMIFIAEPYLNTVFNQSSSFDSIFEFSEETFFSKDENISKEFPRYLLEFFIEKPYENQINLIYGFLDDISTPQFKEYILLVLCLKFPCFNQKICNKEILLRIILECIFLTNILSPENINVKGLISEETLEIDLCDILVENVQNKNIGIKIPSDRKEIIQRYIPETFKFLENMMIIINCANRYLFSKIISLVKEKLLGFKLKISGAFYSDLEIYFTYFLTLELNNTLKASSSFKPVSLPLPKQESQPEQETGIKREPETKHIPETKRETEPQPQPKPESKSLPEPESQPVQETETKRVPETKREPAPKQVLETKRKPETKIEPVPKAIPANKTLKNVHKTKNIPNLPSNTKVEQKNNGTNPENLTEKTRSSKLKKQESKILQSETESKASEEKPKKENNAFRTILIVVLVFTSVIGISATGYWIYLKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE7</accession>
    <name>A0A4Q9LZE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative EF-hand domain-containing calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0272p0030</name>
        <name evidence="5" type="ORF">CWI38_0520p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000272">
        <property type="protein sequence ID" value="TBU03580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000520">
        <property type="protein sequence ID" value="TBU13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0272p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0520p0040"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="137" mass="15952" checksum="3CA8A87B1C5A8D71" modified="2019-07-31" version="1">MEDEIKILFKRININKTGKISRNEFKAFLETLNPKVPNNEIEKLTQKIKPEGMNYELFETIMTNFLKECESVNVVEEVFNIFDKDGNGIISRNELKETFIYLGIKKTDKEIDKMVEIADINKDGGISLEEFKEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZF0</accession>
    <name>A0A4Q9LZF0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0218p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000218">
        <property type="protein sequence ID" value="TBU19126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZF0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0218p0040"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="72"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="42199" checksum="FBDFF1340B1339E9" modified="2019-07-31" version="1">MTQRKQKLVLLTLITLLSFFSGFLTGFLVHENYFNDSNSPKDLSNEETDTFEFIDETKDKEIKFIRENADICPLKNSGVMCYFNSLIQCMYSLKELKNIFLSEDSSNANSGVKKIFKDLFIKMGKKDSSIDTKNIIQNILAINSSQEFKNINKHQDIHALYVFLIDNCLFNGNSINEIDSKEKFDEAAKDSNISKLYLCLEKTHYFVAENRTSTKFEIWNAIIACAKTFDYQMIIDQYFKKEYITEESAENKNVLVNIEIEAKMIRFPNVLVVHSFCYSEDFFFPADIKDIKIENEKYSLVSAGCHAGNTESGHYITIRRVKGNIWAIINDNSISYYKTRNVLNFLRKHRFKPTLAFFEKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK5</accession>
    <name>A0A4Q9LZK5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein Msh5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0493p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000493">
        <property type="protein sequence ID" value="TBU13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0493p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="1">
        <location>
            <begin position="180"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="423" mass="49909" checksum="09790A01EA8BFE2E" modified="2019-07-31" version="1">MNISILYKKNILGVCIQNMKDLFIVQDIYDTHECDILKNIIHTFDIQKCFYSLDLSLERYECLEECQIEFEMLETKTYENSSVKKHLEQFIEKDKYKLSISCLSSLLIFFNCPEIIKEIIADNKKVSCENRFFVGKKVKTVETIKDERQNNFRMSKLITSIGVYNIHLLDLRETLFLSQSTMKSLYLLKEKRHPNINISTKKDFSVIEKIDFTQTTMGKSLLKLWVNFPLLNIKKINERREIIDYIINNSLQTKTTQFLKMCVCLEKNDNNFYQKNKKSYFFKLRKFLMASYEITKLFKNVFHHDTDFISDLIHEIDSKLDLNAKINSVSNKDQNTNETNSNDSILIPFDKSKGSNILNEFQTFLDDDSYIGKTNINFNDIDDKNVFIVKECIIEHLDTLKKTFKELPEYLDCIAKKVSNEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M014</accession>
    <name>A0A4Q9M014_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0455p0010</name>
        <name evidence="3" type="ORF">CWI38_0616p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000616">
        <property type="protein sequence ID" value="TBU12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000455">
        <property type="protein sequence ID" value="TBU13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M014"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M014"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0455p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0616p0010"/>
    <dbReference type="OrthoDB" id="2196318at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120566" evidence="2">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="47134" checksum="8981A374C6C896C3" modified="2019-07-31" version="1">MIFSSWKVNILFCIAIAAAQNVVIIKGKCGVNPADICKANGYEGVVANGQNVPYLMEMLNNNKFASAGVSGWNDHLGNFVLRNNGSLAPFEPLTNNSEYAFCVGPCPCPERPFPIGYRPSPPNQPMPCPPMPVPPMPCPPMPCPPMPCPPMPCPPMPCPPMPCPPMPCPPRPFPPMPCPPMPCPPMPCPPRPIPCPPNPCYPNRHKRHHKKHHRKHDSCSSSSSSSSSDSDCKPCHPKKSHCPSLSKKHCKVKKGPFKCKGKGDVTRLEVDKMFCSKTFIYNPRELFCGDKIKVREIVSKNTNVCKDILLQPLLFGKHREGKLSYPALLRFPCFLIELIKALCERCKIYRPCLYIDKCNRLYVLIHKKLYCIKFMKNVQYFRPETAKCFKLVPISRRKTCKLIQSGLYGIVFDPNAPQCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M047</accession>
    <name>A0A4Q9M047_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit beta of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0061p0020</name>
        <name evidence="4" type="ORF">CWI38_0159p0040</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000159">
        <property type="protein sequence ID" value="TBU19984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M047"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M047"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0159p0040"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="28197" checksum="5F78F9613ADF4B0B" modified="2019-07-31" version="1">MEIKKDLKIKENIFLSNNILQSSEEQETLKESSNGRFNPYENNSGTTLCIKQSGYIIAACDTRHSGEMNINSREMTKIYSIGDFILTTTGFYADSYELSIRLKYQINMYEVQHNKKITIHSAAHLLCNILYSKRFFPYFTFCCLCGFENKIPYIYSYDPVGSYQECSCRCNGSGAGMIQPLLDSLISKKNWNNCTIQDLNDEDGLKLVQKAFEAASERDVKTGDFLEVYIIKEGEIQKSVFPLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E4</accession>
    <name>A0A4Q9M0E4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0132p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000132">
        <property type="protein sequence ID" value="TBU20100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0132p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="276" mass="32165" checksum="6F9596E1B1F98C36" modified="2019-07-31" version="1">MNFNDDNLKDINKYLISPPPPLPSLKKIPLEIQHDFTAHDDSLDSKIPKKLYTPILSVLNIDLFSYVFEELKDGLNENVDNQVLPLEEDEFVLRNNLQSIKEERVVEDTCIKWNEMIEKTFENVNIYEFKEIDKRVEDIKIEKKKIDGMMEEADDNTSDYKDSEIDVVNNHRNEENINLPNEIETVLDVFPGEMRLLGATFLNDEPENIELKNLKNSFGGYSNIITNGDKTYSNLPQDMSEYLLFEIKEDKILYHKIESNLKLNSIKTKNLTKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R2</accession>
    <name>A0A4Q9M0R2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1404p0010</name>
        <name evidence="11" type="ORF">CWI38_0209p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01001404">
        <property type="protein sequence ID" value="TBT99267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000209">
        <property type="protein sequence ID" value="TBU19500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1404p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0209p0010"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="9">
        <location>
            <begin position="579"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT99267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="667" mass="79231" checksum="D3D047ADFD5F164A" modified="2019-07-31" version="1">MHKMCRNFEINNRGKQVMVLRQRMKQILLKPNSKINNNLECESDRFVFLKKVLFRDKEICNKQNNQPLYCITRKKMNKETKILSKLENMFKLKFDFQEQSNKQNINRNKRSNINPDDLRTESVKLTHGYQKLSKIVIKEQPRYKNRTFLNKINHLNFIRDDIDNNLCNIIPSSHPNINNLDLPSEKDRIKSYQEKSEFYGLNDNLKNDLLKIFTDTEDIASQFQINLRSFDSLPKNHVKKIGEATFSDVFCVKQKIFKIIPLKKEKCKLVDLSVNVINSDNIGNTDHKTSENHNSDVFVNIYCETDTRKNMDEDESLMLFKDFYRESFILKILSKEKNVCQFFDSCVLKDGYTKEYIEAWNDFKQFNTSENIFPLNFTKDQLFGCLIMENGGNDLEKFIFKNKAEVKEVFFQTCYFLADMESKYEFEHRDLHWGNILINRLPKKKRENKKKHLNNYAHTLKNKYKISHNKSVMIDDSNQNINELKENIASNNQFVNNAPDKLNFSENKEYINSEEIKEFKSNDIISLESKNITQIKEGVKISKNEKFISKFLNVKIIDFSLSRLNHKGTIIYKDLNEFDWLFEDETIIGEEHLKIYPKMKSNNQNDWKKFSPENNVLWLEYLLFKLQEKGKNFRLVSFFQKAKKILKFSHSAKDVWKAISKIKTCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U5</accession>
    <name>A0A4Q9M0U5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0113p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000113">
        <property type="protein sequence ID" value="TBU20205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0113p0030"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="18283" checksum="645D358D5333CC59" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMTLRTIFDSVTADPKEWLRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z2</accession>
    <name>A0A4Q9M0Z2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAC3/GANP-like germinal-center associated nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0313p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000313">
        <property type="protein sequence ID" value="TBU15322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Z2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0313p0050"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="693" mass="83001" checksum="9779D8C57B06B907" modified="2019-07-31" version="1">MPSNSPNNSFLGTCLTFCPPSEITDRTLRKDISPFEQKCLIKRYQRSSAGKSQSKPEDVRPLEVLIEVMKYLFSFLDQTDFTKKSESSSYLIHDIYKFIEDRSRAVRLDIAIQNLNCNKTINELEKICRFYILFYNILYSHPHFEHHLNIEQLKKTILTLLEIYDFKNKISPEFLSYYILLHLNDPDTFSKAKIFSCKITPFNILGDSFKVLKVFQQNDYKKFIFFMRRSDFFSSSILLNFKEMVRSKYFKVLKRSVVDGKVDLFYVKDCMGIENVEEIKYFLSKEGIPVRKEEGDISLDEIKFEEKFKFFIDLRKKNYEEREIKMVRVLDDWVVNRICRDKVKIIKYGNLDFYILKKFLIFFSKEIFEEKSKNFKIEEIKTEINNLDRKYCEDKDLENKYRENTEICVEKNNSKYFLEFILDKELEENVKIIFKRKFVKKNIESIVLFSVMKELTCDFISFQKRKSIEKFFYDIFIKKWISSNFTTEKIKNLFDKKIVNNQNKSKKIKIKKTEKKGKSLTLNESKQVIVLNSDKYNFKNIQFKNLLVVLDKSIYSTVFKTKILNCKISELNPEFVVMKKNINYEELSIEDISLLDYKCVLFSVDKRFHNKINEHFFMINKIVDLPCNMLIKINNYEEMYEWIILCKGIYKIKLSDITDIGCLLKNRRNKENEVVKTSKFGGEMFVYLEEDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M119</accession>
    <name>A0A4Q9M119_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0338p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000338">
        <property type="protein sequence ID" value="TBU13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M119"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0338p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="533" mass="64069" checksum="5D4AE3D059851BE1" modified="2019-07-31" version="1">MKFNLYFLGSKNMFYILDSLILIFACNSSERDVIVYVAQDIQEHFLNLDITATKTDCFCRIKRDVRDKTIEIEHIKYLLASNNSIKYQKYIIEDIEIFGLKFDIFQNLNAEKSNQEIYLCPHITTSEFKIFYRVIMSYYFAHEKMTIESFYTIVYFLEYLRVQYDDKLRKFLISIFFSLSQSTELEDNVVDKIPLHFSKQEIFSHEFFKIISQEYFEFFKHENNFNPWVFIRENNICLLEKYEIFYTPNRSYLLILKDDFFENISKNIAKHVKSKNLFILVLNTFDIKYLHVLDVKLKNLKICCFILENLQKRLDEIVFHNLRIPSQFIISLNTNQAFIYLKKIVFLESTIITKLKFSKTLNKIDEFIFYDCFIINKENLIAKFEILTTLDKIKDIFDLNKYKNYNYISFSSLFDENIFKEKIKSFKFLDLKYNFWQIGCNIRCNSDFFNISITFYELDLNEFKVKGNVIEKNISEIAIDKSTINCGFLKDILDIYELKNLRIFCSEIFLKENLNFNNKSIEYFTFGAKCDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M177</accession>
    <name>A0A4Q9M177_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0068p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M177"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="26461" checksum="7132A4CCAABA9874" modified="2019-07-31" version="1">MTENNDGKQKNINFIDILDFKESEHINEMIVPETTKLKCKKCNEIVLALYADFHCCYIEENETDFIYKNISTKSVNEINLESNSTDFNKRNDIFKETLVEMPSKTVCSNQTNYFTEDANATDNSKPFKIRLKITNKGKRKKKINKKNTENNEKDSTRKPVIIKDSIKKMIINLKPVVKKKWFFPENKYDTFAMKSTVFNSSNLKIPLRTSKRNNQTTNNQQMNTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B8</accession>
    <name>A0A4Q9M1B8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0314p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000314">
        <property type="protein sequence ID" value="TBU15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0314p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020672215" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14831" checksum="30C7B338FC627CB0" modified="2019-07-31" version="1">MHILLLFIFFTDFISLSYKKRKTQNESKTNTTKKQSITSSHDIGTEENIEIQITNINAETIKNSIKDISEKVFQNFTFYFQIGQIFRKKSNLNENPKVNPFDLRAFSEQLLNGNFCSTKKYEILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1D2</accession>
    <name>A0A4Q9M1D2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0270p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000270">
        <property type="protein sequence ID" value="TBU17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0270p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="92707" checksum="CE2CC4B4266A3556" modified="2019-07-31" version="1">MKKIFINFWDLIKLLQINIGKLSLTIFILSILTPLNFSAAHKFVFKFERNGNSEIIFYSEIQKNITIFEGKNEEYYLSVLYCLDSKQSKTCLNSIFTYKKENFIGFEVLNKLFNFDTSESLNGKIECNFNLLYFLSLTKDISELSEKINSNQLIILLFIFKSLKAIKNKNIFELLQRIFFNLINQRIDEPRSEIFNSEEINKFLTRYKIGFYFKKNLLSAFLKNLMVEHVFYDENLVWVKDTKEIFDPQQLNEHVLYKNLLINDFEIFDSFEMFIHNHFSLNIFQALLNGIGIESLIINNSRSNQIHRSFSSLLKNFVSGFKSLKFSNLTGSTETILRKLNEIPNLNLEFFSMRKSTADSNIFFSLLRKQRLKGLVLDNVTITSDTTEFFDYLTSNRTLEYIFFKDIEITFYWWISIVKKSTMARIILSFDSPFKVNKFIDQFTMSSYKNNILHLDIWFNFFKIPKEFFDFLWYFRCLKTLKIFGYKVDENIESRLYRAIENMNALKNLGIEYSDFSDEIYNYFFEKQGLSILHIKNSFSNQKALNISLFNANLLFTQIILENIDISLNTIFELFKLENLEVLELRLSKLSDNGSSESLNLKSRNIDSLSLNGIVLNSLNFIDIFNKLNCLKTLQLFECRKFPCYLANLGFGCNLTLKTLCYKNGVLHKEDLDRLKLLAVLEKLDFYKCEFIECSFGELGNDCRFLGSLKSLDLSNININIQDLKYLLNFKHLKNLGLFFNYLHLQGVKFNLGRLARIHFSLKNRNIKAKPKNLKRYLYENSIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L3</accession>
    <name>A0A4Q9M1L3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0149p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000149">
        <property type="protein sequence ID" value="TBU20017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0149p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10534" checksum="63082D0C6C249599" modified="2019-07-31" version="1">MTAEDCAKSHALDFYVSDYSICLKKRILCHVMKHYFALFEIEIYSGKLKICSTLSKTDKNFERLATCCKKIQGYNYTRSNIESHPTPNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1L6</accession>
    <name>A0A4Q9M1L6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0044p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000044">
        <property type="protein sequence ID" value="TBU20614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1L6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0044p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="91790" checksum="4EE68460202FAAB3" modified="2019-07-31" version="1">MKRNIIGGIYFIAFLLIGYFDLYSGLEITFRFPDDICEAKCVSGDRRNSDATNDAENNILLPHGGKTDMNKQSKNNINTNICNSIDINDIGIYPIKFEAFLLLENHPNLHILFVLDHVQSSEFRIFDGLMRSYIGYTEKISSRTLLNIFYILNNLKPVRCPIFYQIINILLLNFDSNMNQKENDHFLTKELCVISTKDISFDMVRIFFNQFFHLYISDAQMSNTFSFKMLSDISPTEHESICDGTEKRILSLDHRFLIYFKEDIYSSINRLQLFNTILLLFKIQCIHILYLNEDNLSRFKIFFELILNEIEIIIFKNIEYSINIEIFIVDLLKRINVKQIYFIDPLFEKSILNTQMYAIKPEKIIFLNFVNRESCESFINTPSPSLDNIQRYMMEKFDLDFVKLESSDLENRLQSPKYNLANYNGFKEIYKPESVKQKFELYTFFNYTFPSCEISGLLSDDNSLKNIKIIFSNIFILNIEKFKIFSLENLTSMQLSQCNLSLKALIDIINLPNIKNLEIKKSEIIIPNFKFQYYKTKKSLISFNFIKVKVNSSIFFYNIVNSLNILKNLQLKLLNITSNISKEVIFSKREPTKLKSLYLSSYELLKLDKFLLPNLEIIEEITLKNISLNSPGPNNYGILNIKNTKSVTLKSCQINSSEKHFFDLSIIQKLKINACCFVNISLYEIFVQNNFYAIESFELKKVQITEKDVSTFALFVNLRYLFISHCDFIVNAILDIKKEKYANLILFKLKYYKEQINFTCILHLQKEFEKHLIIDSSTDLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R1</accession>
    <name>A0A4Q9M1R1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0047p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0080"/>
    <dbReference type="OrthoDB" id="2186513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43610" checksum="BA0BF828DB7DEF00" modified="2019-07-31" version="1">MINTFMIFIPLAYMFRGNSSNGIDQTTFVSEEISTISSAHENYRKSHKAAQMIFTEDDESTISCTSDDKNNLEESKYEDYSRIDEYESNEVPNNIYDSNLCGGFYYPGSEKRFIFANSPIFRVYFKLSRVKIAIESFKSITSDFQREINKKQINNTSIDVLLFSLNTIGSFSDLSFGYIESYAKNIEDSLAFLKVGITFLQNLISYAESYCDGFEKTLSELNDKYRIFLQEIIKGLDVECNSSKGASKKSIVVQGGVIIQCKNKKRGDIKGCSSLEGVIITQVLFKIEHSVAHSGINRMIALIGKKYYRIPRTFIIKYAKVCGACSRFNYLKKIQKIYMKNITNNYDIFMIDCVNLGKYADQKDGIVGPESNRHLYNAFPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R2</accession>
    <name>A0A4Q9M1R2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0036p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000036">
        <property type="protein sequence ID" value="TBU20674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0036p0030"/>
    <dbReference type="OrthoDB" id="2196354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="509" mass="60294" checksum="F71B31700CAEB782" modified="2019-07-31" version="1">MNLETPIENKENTNKIQLLEEKDKNNTEMGQMLSSRNKEQILEEKDKNNTEMGQMLSNRNIEKSNDNLNEDYVDLLQENIEEFKSEKNIKKHFFTSAVVDNPDKRHTFKENLSALKYSKIDLSSNLFDSFLDIESSCSEHGNEIQNEGENIYLSNIYGLFITLNEKIDQIVIKESNNESSKEKMKEIFGKIFFLLNNKRVSEAKVMLKDLFLILFGNFENIEEFLSSGKEYSQVFLNERIKPLIKILNESKNSLKELSGYISDKFMEMKGSFIEEREKFKFEAKESLSKEKQTRKIFEMEIRKFLQKEFELNEKNVFESLKILKETILNLKNTKKNEETKDLKLKERNLILENEISNLKNEKSIFDRKNEELNKRLAFLESEITKIQNENVSLSESLNKYTEKSIKLKKEYVVLSNEIINHRESNKKKNSVIEKQKKIIDILQSKISGKKDENDFVFPISDIKKNIEKLHDDLNNETDEEKRKKIQKEIHNFEKRLKDFLNFKKETKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S0</accession>
    <name>A0A4Q9M1S0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0175p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000175">
        <property type="protein sequence ID" value="TBU19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0175p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="21516" checksum="249DCA00784E206E" modified="2019-07-31" version="1">MGEVKTELDKIKEQCDSKNHSSGDSTSNSFLKIQFYGFSLNPSSGKPTSNPLSNLSSELFSGNSSLEQPKDLYSLIIHRFSDLEEKSTQIKKMTSYFKEIQELIILVENHSGSKLEIISEHINELHPNIGLLNQARCLFGDKYFAMQTEGINIELFEVMIAEMIKNKFETNVVKIFKCIEKELQPMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1V7</accession>
    <name>A0A4Q9M1V7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF382 domain-containing putative splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0128p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1V7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1V7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0060"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="364" mass="43000" checksum="AFE90CD4E6051042" modified="2019-07-31" version="1">MNNKEIDTNIEQEYKEIIEKNRNIILNKKVESKQKKIQKENKKARKQKIIQMKYNFYKPIVPYPLLLDFEDVTYEDPIYLNYIKGLENTVPVPKYWKNKKSFLNVKKCINKKKYVIPQNILETGLVDMRKSIRNKEDNMSFKAKLREKLYPKTGKCFVEYQKLYDCFFKHPNEIEYLRFGELFRPGIEMEKKIKLNVPGRISKNLMNVLGIDKTLPPPWIFNMQKYGLPPSYSDIKIPGVNAQIPIGSSWGFQPTGWGQPLEGYEELMNINFTIPSNIFEETNNKNQDLNNEETISDTQQNDSESEEQYELRMSDFETDSISEPKVEEIKPLEITKDLISTKEEKKEPMISKKTKSKSERKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C7</accession>
    <name>A0A4Q9M2C7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0017p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="662" mass="78276" checksum="F0F679B741873C9A" modified="2019-07-31" version="1">MFMKYFYILCKLNIIYSSRYINTDCYNSLKKESSQANYDLNTNIFENNKECLNEANDTEHFCNSCPILDVTQQIRTADNESDAQYEIKKEILSEFFSNGEEKYLEGNAKDFHNLGNKVQKNKKQMLRYHPYKKRSISVDLSRNYSSETDTHFYCNKVEKQRTSDIDKHQAGLEFRNDTSDEHYNSTEQRKTPDFFLKSEIVDPLYIDSDSDTKSFLESSSTIDISKMSKSKLEIAKESLEHKLDLLKKKYQEKIINTKGKSYAVLNESRKELFSSDIQTFISGDFYIDANYLQTDPTPFFDLIDSVAEKEETFWHKSGNPGILRNIGENMLECVEKINLYNDNSPIFTYYPGLIHIKHFIKNIILNDINLVKNSCLWIFLLKFVQSLSMFPLKNKHLNQISSGKNCCPKYSEYDAYNGDNYIFTLIRSQYELFDTMARHIFKKTEIFPESTQMLDFINKSLYFSNKDIHISLGKPIGYIRVIRDCMLRMSPNTISIFILQMEKQKLINLNGGEFRSKISKFFWNITHEANILNDESIVDFQIIYKRIVLAYIDFFKHEALQIKFSKSKNFCYLENINSTFYNLFEPYYIEKLLINQLNFKSWSQTAEALCVLFNFFIKCGWNSQAYTESYEIQAFSECNKRLEYIQLFLKYHYNLKMNFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2R5</accession>
    <name>A0A4Q9M2R5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0093p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000093">
        <property type="protein sequence ID" value="TBU20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2R5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0093p0030"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="651" mass="74507" checksum="C153B82AE638D7FA" modified="2019-07-31" version="1">MSNLYKLTTKCVTKVVQLEVERRGLLADNQLGAVRGVQGAKKQALLNVSLNKEYGNNLKATWIDVTISKWKIDISVGSEKIMNKKIDKGILQGDSLSPLLFVLCMDPLSRKLNEEYAKVTIQTEDASHSTNHLLFIDDLKLLAKDGTTLEKMTEEVKMFMKNIGLEINREKSATNDSCCENTATLLEGIGVYKYLGIIEDSRGIPTRKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLINYHIGVLRLEPGDFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDILEKSKETSTRRAAILKVTKNKLDEAQLANLYNEIEKRKIHSKLYNARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRLNEVVRCIHLLLLNKYKFKSSKRIRSHSVHEILDNEYAEIRVDTRIKTDITLIEVGITSQDSLQIVETEKLRKYDLLANDLGLIYKCSVEIIPYVITWDGIVTKYHKTYLKRLQIPINKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTSPLKEVKNEEDSVKQVNSKNILPLILDDVTRPKEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2U1</accession>
    <name>A0A4Q9M2U1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0155p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000155">
        <property type="protein sequence ID" value="TBU20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2U1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0155p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="93574" checksum="633F3A0D2346F889" modified="2019-07-31" version="1">MNIRSISEFKLNYTYIYVLYFTIHVYTITASKYIYWFEENEDSEIILYSEIHENKVFGSDQEEKYYLKIIDDINSTVMNRLNYSFTYDDENFVNFAVFNDFSKENKFKTRKAMIECNFELLYVLKITKNIFELPDTISFSQFKCLLFILKHLKAYENKNLFKLLQGIFSIIYCNKNDKKLINKESYFKEIFRFMFSSESTPNIKKSIIQALLNILMIEHIFYENNLILTTKNENIFKTNLINENIPYKNLVIHDFKAFCILENFFRNRDISNTFQILLNEINIKSLIINNYQGTEFIDVDFIFLKPLAHILRSIIISNIFGSSENILNELYNAPNLKLEYFSLINLIVNCNCLTKFLSKHRLKGLVLNNVTMYNDINNFNSYMNSNKSLEYIEFKNIITNFSWLNCFTKTSNIKKIVLVFESDVIEKDFIKECDLLIHSINILYLEIWFDRYIISKEIFNFLKCLKSLKTLKLYNYKPSSNIDCNICEVFEKMKALENLVFKNTYLSDKFYNLLFQKKELKFLDLISSLNPKRLLNLEPFNNYCSITHLILRSMKINRHGLLEISKLVNLKELSLKFCDVESVENTPPINFISRSINKLCLKSSNLYNSEFVGILSNLDELENLNLADFLLHSCCLSRLNIGCNTRLKALSYQRGSLCINDLNRLKKLKVLEKLKLYKCKFIYSSFSSLGEDCEFFNSLRHLSLWDIENNLITIQYLLNFKNLQDLELPFIPFNYSQLQISRVCLPKGLFLTEELYKIIKSKNFYNEIYSDNISKYFKEIGIEAVLKCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M393</accession>
    <name>A0A4Q9M393_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative kinetochore protein Nuf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0144p0090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M393"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M393"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0090"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48441">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48441:SF1">
        <property type="entry name" value="NT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="258"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="52385" checksum="0C22EBC2243E6E40" modified="2019-07-31" version="1">MRKTTKKNIYYIPDFSVKEIIQYYSEMQIQLKPSELLNPTPLSTQKLFETFLQIYKGEKVSESVERIIRNTNNSIYEESLYLVFLLKKLSSFFEKINYDGFSSKDILQPDSKRIISLISHIMNFSMYRDNKRHVYEKIIRKGLEREEIKQDIENKIRMQENILLSQEDELKRNKKVLEGLKEEIECLEKDLKEFFKQQRQKANEVEILKQKKSEISDKISSTQLIVVNYKQEIASLKTQIVNDPKKLLELLKEMKTMILKEKDSIKLLESRYNKLKEKINNFEDSISDLRRILKTAVQIQNFKKDKEKIIKENMILESESKNVSSYMDSLDNKYSHIIKQISHLETKINNLQENDNSYFYGITSRMEDLKINYDQISESRNETYSKIEVNNKKIKEYEQESLKLKENHENEMMSFQSALCGIKDKIYNYLNELNAYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3N0</accession>
    <name>A0A4Q9M3N0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0021p0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3N0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0130"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31047" checksum="3255D58539B44E0F" modified="2019-07-31" version="1">MNPVDDIQTDTTQCEKRLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPNIFILDKKKNKITLIEAGITSQDSLQIVKTEKLRKYDLLANDFEIIPYVMTWDGIVTKYHKSHLKRLEIPINVEACIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPTLSLKEEKREEDGVKNFKPKNKAPLISQGGTTLEEPTNNINKESDLKEETEVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3V7</accession>
    <name>A0A4Q9M3V7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0075p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000075">
        <property type="protein sequence ID" value="TBU20412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3V7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3V7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0075p0040"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="190"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="379" mass="44486" checksum="1887EB975E06E358" modified="2019-07-31" version="1">MIGKIKIQDAVNNSAYGDDSLNKTVSLPFKSDELIRLFNSLEKGSMRNKKLLPVHRHLKNQMITKTDVSDKLAVICTKIDALANFKILFCEFDLKYLVRSKHSINKCTSIVKMENIRVINQKKVQKKYCKTSLRALEYKETVQYFYDKLEYNQRKKISSYCRFKLLEKPKKRCDCFFGIFKNIFSFGKNSKIDQKIPINPFIYEIGEHLLANGVETEGIFRISGKASTYRTVPNVLKDNKRYNLNDFSIHDNASIFKAYIREILNGLIPEYICEELIATIKGSPSHKSLYNLVFYSRFCFDEDVRKLIIFLKKMFITIEKHIKYNRMTFENLVKIFTPSLFPNYKHFDITTINTQIEFIDSLLRSDLHEVPLEIMNDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M402</accession>
    <name>A0A4Q9M402_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0067p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000067">
        <property type="protein sequence ID" value="TBU20462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M402"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0067p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="146" mass="17081" checksum="CB65AAA969788496" modified="2019-07-31" version="1">MTSQDLKKRRARPRDEAGAEGIFNTATKILDRACRGKKDTRIKTDVRIRCNRPDLLVLDKRQNKTTNAINDEAYIQSTSELNTKESRESQLDNEEDDVLKRKKRKYFTPDLSGITYWEPKINANEDSKLEDELEDVKIRKRIILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M473</accession>
    <name>A0A4Q9M473_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0002p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M473"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0010"/>
    <dbReference type="OrthoDB" id="2193722at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1010" mass="118012" checksum="36BDE998EF43D22C" modified="2019-07-31" version="1">MISENLKNILSKIKISKSISNEDLSFLQSNISQDTQKTLKVISLIQNTIDIPSSLIETIFTFYTTNFTLQDTISKSEKPMSHNEFIKIFYFYLKNDHSFIKKIINYLENSDTINSVVFNMSLLLFVHIGECGCMLEPSKFTTSTVYSLVVMKMNGENVILFEMFLTYISTFISKYVIYFLKKNSQEKENKFFYKIFSFLNKVANIKDLSYFTSGGDSSIEFYEMLSTLVLDEESAIQCFSCLKTSNTFSQLFSAVQSLSKLSIYDSKKIQPTDKKYILILLEVSNKILEKSFGKCNLYFLRYINILVEFIFTKIDFEIKNMIFIFLSFFKEKEEIENWIKCVEYCLKEGICEEEEEGFLRLCYVCITEYEDLDYEIFKRIAFVSFIGLSSSNPNSVFNSLKILLKCEIQSLIPFFSKKPFSFTSGLKNTFLKDARLIGMFIELCCKLSNFKSSILEPLLYDVSFMNLILSYPQKEIFNFVSIFSFKEFSIFLNEIFSLIFLFPLEGLKYLERGTKECIEFCRFITERKEYFNKYIINLSNKVLNNIVEIEDLEKCSNNIIENNDDHLISKIDEINILIISIYNNILDFYFIDVSTNRRNETFFINFVPCDEIYEMYAKLTIKGHLNGFDTDYYKLEITNVKSIRRWCDYLKCRMVVGDNIEDILANVIGGICTNEIEDLIGFYNGVQESEIPEKKSKSNLSGFRNSNSVDEFLESRPLAVSNSLAIKILYSFKKKNNEMFLKYFENATDWEKFLLFFILDYKSMHLYESQFSYLLTFECKRTSKKNDKNSQILLSCSLHALIYLKSLNSAISMLKILNIPNEFYPLLSKINLMNLLNSGTNTFDLNLLKLSDVPTQIGNIILIDLNNFFIYSLFIFISFYFFIFLFFDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDEEPTNNINKESDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4G1</accession>
    <name>A0A4Q9M4G1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0012p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000012">
        <property type="protein sequence ID" value="TBU20888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4G1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0012p0040"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="31220" checksum="CB6F22BFBF866417" modified="2019-07-31" version="1">MGFEPRDKQFYVIFKVEMYSGRAESVCQHCNNHSVQEILYNEYVEIRVDFRIKTETDIRILDKRTNKMTPSEIGFTSQDSLQIVQTQKLRNYDLLANGLGIFYKLYGIVTKYHNMYIKRLQIPINLEVYIQLIVLKKTVQTISFDRQRGLDVILGAEMYKQPTSSLKQVDKEEDSVKAENTINIIPLIKMAVGLRGKDRSELKYTDYPQYKHLRTTRRYAYLFVTAFYFHTSNFLCKNSEIRSSLPIDMERLFSIKGLDATLSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4W2</accession>
    <name>A0A4Q9M4W2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0043p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4W2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0010"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="29053" checksum="473770B535FBC2F0" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQKEKIIKAANSQCKNDQGIPQPSSYTPSTIINNISIPPSETNTNTKVCLLNTIHSPSNHMHSSTVTPRPDIAASWPNLCTIPISERLFVLRSILRSIEAERQEFIRCVLFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDATRFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDSTVLDLINRIVGEYADSHVPMTITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M505</accession>
    <name>A0A4Q9M505_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0038p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000038">
        <property type="protein sequence ID" value="TBU20661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M505"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0038p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10680" checksum="88D26C2809D66527" modified="2019-07-31" version="1">MKDWLIDPVWVISQKETSMVFTQILRPGCQSDSFIYSYPLSTLISTRNRMKITVKSSPVYKANEKRREVRPCNRRIDASNKNLRMLNEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JU95</accession>
    <name>A0A4V2JU95_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_1377p0010</name>
        <name evidence="9" type="ORF">CWI38_1353p0030</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001377">
        <property type="protein sequence ID" value="TBT99341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001353">
        <property type="protein sequence ID" value="TBU11155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JU95"/>
    <dbReference type="STRING" id="1176355.A0A4V2JU95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1377p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1353p0030"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="7">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBT99341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="117" mass="13713" checksum="8519C68268F52A82" modified="2019-07-31" version="1">MQTNRAPPTRKQKLKACMNCSQIKQSNLFRRDGCENCEFLNLKNNHENVIECVSDRYKGMIGTLKPEKSWVAKWQRINSYKPGLYAITVDGILPDEFINKIEQNGRVYYPRDKPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVD0</accession>
    <name>A0A4V2JVD0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0300p0020</name>
        <name evidence="1" type="ORF">CWI37_0450p0010</name>
        <name evidence="3" type="ORF">CWI38_2077p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000450">
        <property type="protein sequence ID" value="TBU02581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000300">
        <property type="protein sequence ID" value="TBU03402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002077">
        <property type="protein sequence ID" value="TBU09994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0300p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0450p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2077p0020"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14870" checksum="9E02BBABAF75BB4C" modified="2019-07-31" version="1">MEDTVREKYNYFVSNQKLNKDTFKDLVRLCGYAPTEEQLNIDVPETFEEFEKLLVSFEKKYTKEDLYNELRALGDDEYISTDELRKLLTSGNDKLTEEEIRSFFRAVETNGNEVSIRDIVDLLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW99</accession>
    <name>A0A4V2JW99_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2472p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002472">
        <property type="protein sequence ID" value="TBU06992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW99"/>
    <dbReference type="STRING" id="1176355.A0A4V2JW99"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2472p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="506" mass="55530" checksum="569DD4E4668A0644" modified="2019-07-31" version="1">MYKIFGSLDFLGNLSSLVDSFSLGVHDLFYEPYNVLSNSNSNSIDFSIGILRGGKSFIKNTLSGVSNTVSRVTSSISKGVSLVSLDKDFNEKMNLSNNLIFYLDDELLFPDKLVFTNKYDRFVESCVSGVRGIVEKPMEGFKKGFRGFLVGVGKGIVGAVAKPVAGISDLACSVSEGVRDRVSGGEVVRIQVIGVGGYGMEIGEYGIGEYEIGEYEIGEYEGSKLEGVSDKGSKLEGVSDKGSKLEGVSDKGSRLEGVSDRDSRLEGVSDSTSRLEGVNNSTSNYHPVNNLSNNITDISNNPHNTNAILGLPAGFKVVERDTLYDLDRSKSYYIFNKYIKEGYFIDGCVGVIGLESIMVILIREGVVLSGKECFCMVEWKDVRIEGNSFYVGKVCVVVYKRGFISKMVVVKGDRRGDSRVYWVIEGYKGIYKGVNNSTIIIRVLIIVLINNRGVNNSTYKQQGVINSIDKQQGVNYSTNKQQGVNYSTSNYYPLNYLLLSPLLTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX28</accession>
    <name>A0A4V2JX28_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1945p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001945">
        <property type="protein sequence ID" value="TBU10202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1945p0030"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="46775" checksum="EEB6A980A437C808" modified="2019-07-31" version="1">MKIMKCILGADGMCQHCNKSGKTVDYLATRCEKMLGHGYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQKILDNEYAEIRVNTRIKTDVKIRNNRPDIFILDKKKNKMTLIEVGITFQDSLQIVETEKLRKYDLLANKLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNYLRRSETISFDRRRGLESGLNAEESWERASMCVIMRSEMHEEPTPPLKGEKREEDGVKILKPKNKTPPISQGGTTLEEPTNNINEESDLEEETIVVKEIILKIKEISTRRTPKVETTNKTQLAIIKSFLKVKHMLEAEINKTKNLIQNYIARKNEFVGVMNQNGKKEDHLAARLIRFLHLFLKRCKFMSTNCFGSHSGRGIFDNVYAEIELDTRVKIYAKFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY61</accession>
    <name>A0A4V2JY61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0179p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000179">
        <property type="protein sequence ID" value="TBU19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0179p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="46155" checksum="E10BF1006A5C6237" modified="2019-07-31" version="1">MKTKGLQSLPKAVDFVYLGCNENQIEVSAAGISNYIQSKPSNNYQININIPNSGFDTNIESIKLKLFNLERIRNNIWSMSYISLKNGYPERYQQKRLIFLYKNTLQLFLSKIFQIYKSIRTITHIFNDVSNFFVSIEDTNDGITKKIPKRYLSEYIDSFRDPNEGIWIKIFSESEILDNNVSKNKMIQIFKNFYSKWFRIPHLNYTLYILDSCDFELDESQYTKKVLKKTILNQYFICRFSTLSNNTDQTEEFFLSQNFKFEHCTSTTEFEYLYSTKNTEDEDYKFKLSLKCAYLTFEFNFNWYSTRHPITRYWPESLLYIYVIAGTNFDILEISRHRNRKYFVIKRANTIVSSLFCDFVKDLKYVERNFTLDQLFDHLVFKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVA8</accession>
    <name>A0A4V6MVA8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0872p0020</name>
        <name evidence="11" type="ORF">CWI38_0389p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="PITJ01000872">
        <property type="protein sequence ID" value="TBU00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000389">
        <property type="protein sequence ID" value="TBU13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVA8"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0872p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0389p0020"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033455048" description="Glutathione hydrolase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="513"/>
            <end position="515"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="565"/>
            <end position="566"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="687" mass="77300" checksum="B50D7E2BC3D949F4" modified="2019-07-31" version="1">MTKNFMFKFLLFYLYIEIIIEAAPLKSKKINLVSSANGLLEKETYKKTRNHDSSSDNGELTDDKELSNIRFESGVVDRASNSLDDISTNEKNDKKGNIKTLSDKTAEAELKQEDVLEENPVKGDVLKPRCIDNKVYFPGGNTHEDICFTSAAVSTEVPESSEIGVKILKMGGNAVDAVVASTICVGIVNSFSSGIGGGGFMLIRIPDESKENGNFTMIDFRETAPGALNTNLFKDKHDHIKSGGLAVGVPGEIAGLYLAHQKYGKLKWKDLFTENINIAKKFRVSRQLRIRIENFKQQIFSDPGLSEIYTKNGKLVEEGDFISRMNYAKTLEKIAKDPLSFYNGEIADKIVKSISDKGGVMKKEDLTKYKAIEREVLAGKYREYDIYTTSLPTSGLSIIEAMNILEHFDIKEIKEDSEKNKSYLHYHLLIEIFKFISARRGEFADPDFMKDPKKLVAEIISKGYVKKIVDLIRFDGVLKDKEYRYGSPTVEDHGTTHLNVIDSDEMLVLLTSTINLEFGAKFMDKETGIIFNDQMDDFYVPNILNSFDLGNMPSNILEPYKRPFSSASPVILMKYNEILMLGAAGGTRIPTSIILVIFHLLLNKRLSDAIMEPRIHHQLFPSKTFVEDTFPIEIRDYLRNLGQVIEVSRQNSIFTSVQGIHMIKNKDGEKIIQAFSDKRKGGESAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVH7</accession>
    <name>A0A4V6MVH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2352p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002352">
        <property type="protein sequence ID" value="TBU07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2352p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="34827" checksum="1EF22DD9710E98BB" modified="2019-07-31" version="1">MANSTIRDSVRGIIMCSYELSYYLKLTKDITELPDKFGINKFRFLLKTFKFLNAKFFEILIFKEFACQNKNNSKECNFYFDEIFKSGFLTDFDINMKMCFLSAYLNIFMLKCVFQDGNIILLENSKDSYDISFLDEHIPYKNLLIKNFKVFCCLENILNEPYFLNTFKAILNEMNKKSLIINGNIACIIPYKKYYFRILSFGLFKSLVIANFDSPPRSFLYELDSVIDKNIEFLMETLLMKEKHKGLVFNMVQSTENHIESSISVILTKSSLNLIIYTLRKNLWMSLSKSNNTEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM0</accession>
    <name>A0A4V6MVM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0907p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000907">
        <property type="protein sequence ID" value="TBU12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0907p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="776" mass="93573" checksum="6F08DE8105D9FEBA" modified="2019-07-31" version="1">MFKTTSSDIKIYFNTICRVRNIFFCFYMFKYTMANKKYILHFYNELENISEFLNDLKLHEAALSKFINKDYKCYQHTIFTNCYKIEIFSENIFPLRFNSKDSDTEINNIYIKDKILNHNEFIHFRYFIRQFPALKENLSLVKLLRFIRIFDVFEFENDKESKLIIDQMIEILLLSIAYNIRFKGVSKVSEEVGINFSVSFLKRFFFKILKIFLFNREFLNTIKLKNEIDTNICDVNLKRIFDLNDFFWFDTELFREISKKARISIEFKNLLTYFFHYFLIKKVVFSGIHEYTNDYLSVCLLLLPSINEICLVSCSDITFLKFLNKYEVLKNITTLAIINSRVDICSSDFSKLIILFDTIIFLNSNFFKSISINENIFSITEIITKFSNEISNNNKRSSFFHLRNNTKYEINTKDYKFSYLYSPTNFKNLDIKVKKDSVRIYYSVNIEYDLIKFYLLILNFEEIIYFDIYIENISIKRLIFKELNIKNKIKNIYIFNSKITESFLNDVLFFPNCIGISFEMCYFEFDNLDFHFKKNLSIIYLKIDKKCEINYFEKILEFIDVLDNLESLNLNYNDLHLLCINLYGNSKFSWKKIKRFELYEISNDENILPNFSFFPNIQELVIGKNYQDGMISHIFSYKNMENIHNLEIDSYAIGLKDRAALKNLRNLKNLRLEYCDFENIAFSDLFDIKDEYFIENLKLSEIILEKRDIIFISELKNLKSLKLNFLFFKNFSYLTLKMKCFKHPTKLELEINIYWSLKNKLCYFMEEFGPKYLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXS0</accession>
    <name>A0A4Q9KXS0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_1220p0020</name>
        <name evidence="10" type="ORF">CWI38_2637p0010</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001220">
        <property type="protein sequence ID" value="TBT99777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002637">
        <property type="protein sequence ID" value="TBU06131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXS0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1220p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2637p0010"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBT99777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU06131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="203" mass="24193" checksum="C60AE22AC644FCCD" modified="2019-07-31" version="1">MGILNSRVLCEEEIEDLLATTVFTKQEINILFQRFRMLNRSQQNYITFNELMLIPEFHSNPLSGLILSAIENYIQYENMTFAYFLDFMQLFSHKTDKKERIKFIFSAFDINKDKKICKDVLLNIYTLMNGNSNICIEQAEASVYRVLSLYDRGNKGYLSYKDFIRFYTSDPSLDKAMVIDFSREIERYPKFGFRQFFKLNFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXU6</accession>
    <name>A0A4Q9KXU6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1216p0010</name>
        <name evidence="6" type="ORF">CWI37_1729p0020</name>
        <name evidence="8" type="ORF">CWI38_0032p0030</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001729">
        <property type="protein sequence ID" value="TBT98496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01001216">
        <property type="protein sequence ID" value="TBT99786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000032">
        <property type="protein sequence ID" value="TBU20698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXU6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1216p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1729p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0032p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT98496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="155" mass="18253" checksum="720ED9DBF30A41CA" modified="2019-07-31" version="1">MEESILERIRLLEEILKEVKDKETVKEILSQKYLMLNSENVYKHINNKQNVDRFDEQKIKNSSKKDLTKYLYSIIEKSREYKNVVENFKECGIEISGIKSNNVCPITLKKIVDLYVGECGHKFERIAVSELRKQNRICPVVGCSKVLREKVERNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXY3</accession>
    <name>A0A4Q9KXY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1316p0030</name>
        <name evidence="8" type="ORF">CWI38_0688p0030</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001316">
        <property type="protein sequence ID" value="TBT99515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000688">
        <property type="protein sequence ID" value="TBU12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXY3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1316p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0688p0030"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="384" mass="44501" checksum="2843AD19C7F8DE19" modified="2019-07-31" version="1">MLRGTAIDPLENLKTYHYECTDKSILANKVLNPYYDWVVNLIPLWIAPNLITVCGLLCVITSYFITVNHDPELIGAAPRRIILVNAILFFLYATFDAIDGKQARRTNEKSPLGQLFDHGSDSLVCCMSSVLVCSAAGFGRSVSFYMFLFCLMIGFYCVALEEYYTGIFNLGYINGATEGVYSVILVQLITFIFGKNFWNFSKNNFLEKLFCKLLNIKFQNYFETDFATFCFLFSVGTIIYTLYNIKKYKKKRRSRRSLLQIFQLLAILGLTWSARYIFIRGYALIFFLQLFPLFFNFSILCTQTVYSHLLKEKIPMPIFSYFLYFISLSILNIRGFGIYNVIIIPILSMVSSFLYFQFVFDIVVEICNYLKINCLTITKRNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2Z4</accession>
    <name>A0A4Q9L2Z4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing chromatin remodeling transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0614p0030</name>
        <name evidence="7" type="ORF">CWI38_0126p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000614">
        <property type="protein sequence ID" value="TBU01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000126">
        <property type="protein sequence ID" value="TBU20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2Z4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L2Z4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0614p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0126p0020"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="170"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="291"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="377" mass="43867" checksum="9A9BB4A99803BFC1" modified="2019-07-31" version="1">MMVNEDFSLSPHQDSQQDILESQLKYCKEIITRLKRYNAALPFLEPVDPVKLNIPDYPLKVKHPMDLSTIKNKLDAHEYSTPSEFKSDFDLMISNCFIYNPKDTYYYKMGVELEKAFNNFYVKLPTQSKKTKRKEDSSLSSKAKKIVKTSLKKEDYDFCDSILNEILKSKNKKFNWPFLKPVDIKLVPDYSKFIENPTDLSTIRNKLDSNYYGSVEEFRTELQLMIDNCHTFNLPDSDIYLCGTELQNLLNSLFERTEPTVFKEKDIFIKISELKKKKAAIEREIEVLESKLSGKKEIKTYSFAERIDLGNTLMRLNEDKMTQVAMLIKKSMPEFDILNKDEVEIDMRVLPDNVVGEIDGYLRDVTDDGIISDSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3V0</accession>
    <name>A0A4Q9L3V0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0613p0010</name>
        <name evidence="7" type="ORF">CWI38_0396p0030</name>
        <name evidence="6" type="ORF">CWI38_0499p0020</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000613">
        <property type="protein sequence ID" value="TBU01856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000499">
        <property type="protein sequence ID" value="TBU13223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000396">
        <property type="protein sequence ID" value="TBU13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3V0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3V0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0613p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0396p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0499p0020"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445380" description="Peptidase M12B domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="341"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="652" mass="75707" checksum="BFD3B3A0B2EFFE4F" modified="2019-07-31" version="1">MIVLFILFHTYLSINRPNEIYDDTEIVYPVFFTANNELPTIFTPRIYMSFKAFSEEFKIILLDNSYDLEIEDGSSIQGSNLFFGYKNEISNPEIKKEKNILYSEYKNDINLGNTEGMYNKESNIFSNTNQDPIKRKTLYIPVLKHHPCLYSCQVIKDPSSYGEFDLCNTIKGKFVYKNVYYEITQEKEIKPYNGTVYAYKIIRIYNRNENHGNNEPFIKNKQNNVIETKKILEEQKNTVDLKIFFINDLPRLELHKNDILKNTNQIFRRTADILSREDYHGLKINVQLMGILNIVGYKTKTGDFISKKADFDGDERERANYFDDNTISHIDSYKDYMSKNLYDFSVWFSLIINKTYNLSLLSPSYFYILLSTNSKVEIDGLSYINDQIQKNNFIYVTLRSFDSIFYGGRVVAHEVLHSFGVNHDDEEGCDKNGYLMEDIGCVECRENDYFMSNCTINKVYDILKETLRDNFIETELEISQKPLSTFQKISKKKKNHLVNDNCDSFLPFGSLCYSSDCTPRALFCKEEFTYETKSNVYEDKCMNLPDNSPCLGGFCMKNLCINRNLLCARLGLRYSPTCSKSCTLSCVDENGQCVQQYISMPNRSECLSNSGNKGLCNSGVCIVRREDKYMIVLVFSMVIGSIGIFIILWLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L619</accession>
    <name>A0A4Q9L619_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0446p0030</name>
        <name evidence="3" type="ORF">CWI38_0808p0020</name>
        <name evidence="2" type="ORF">CWI38_1877p0030</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000446">
        <property type="protein sequence ID" value="TBU02605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001877">
        <property type="protein sequence ID" value="TBU10285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000808">
        <property type="protein sequence ID" value="TBU12310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L619"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0446p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0808p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1877p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="156" mass="18823" checksum="2D60A81CBE7E12F7" modified="2019-07-31" version="1">MYNETNILQISENSYSIVSSADKKVLTPENIIYLIIFWYSVNYLIKSKCFDSYKKSDLEEKYVDIKDIKGSNIDKLMCKIFLNILYSSWNIDFTGLRNEQFLDFIWFFYDLSCYSESDAIYIFYKNLLPFLFSYVADRSYFNVFRKPESEFSKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDC2</accession>
    <name>A0A4Q9LDC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2693p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002693">
        <property type="protein sequence ID" value="TBU05854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2693p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="467" mass="56230" checksum="3FC4D19B58B52B7A" modified="2019-07-31" version="1" fragment="single">NKTNLSSEIENNIKPENLSNELLNTSFNFESDFSNDTHIFEILEKIIENITHLGDISSFKKLFQFINLFPNQNFIAEIMLLLFEQNHCNIFTLIYSAELYIYNLNIIPFEKNTKLSLYYSKRYEYFKKAKIYDFLKLTENNLKIYDENDPGMIKYFLLYFIYKQNTCLGIFKKYFFENILNILKLEIEFENDFIVVTSLFIFRNYLKITDNESYSEFIEVFGIEMCEKYKYIEIFLSKKEKILNSENIYEDENSMNEHIYDLNKSNNEIQKSHEECSFDISKFGHMGKNNPKKDSEPVFDISTHKSGTTNINRENESDLSLFRFFSERIKNLDSNNSKISYFIKKFRKDSFYNIFLEKYYSYERIEDLLNDFFNLKTYFSDISTLFKMKLIHLKDIDKKTFFLSEFDNTVDEMYNLNIISLEIINILKEKTFNLKNGHDLRNITYFEFLNIFCSEDIIFLLIFIFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LET6</accession>
    <name>A0A4Q9LET6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2664p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002664">
        <property type="protein sequence ID" value="TBU05995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LET6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2664p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13824" checksum="6F00642A9562A175" modified="2019-07-31" version="1">MTWDEIPMNVEAYIQSIVLKKTVETISFDLRRGLESGLNAEERWERASMGVIMRSEMHEEPIPPLKEAKKEEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGE3</accession>
    <name>A0A4Q9LGE3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2660p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002660">
        <property type="protein sequence ID" value="TBU06010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGE3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGE3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2660p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="529" mass="63375" checksum="F2586716B0B408FB" modified="2019-07-31" version="1" fragment="single">VDEKGVEEMKVEEKVKEEEENEAVKVDEKGVEEMKVEEEEKEEEENEAVKVDEKGVEEMKVEEKVKEEEEKEIVKVDDKGVEEMKVEEKEKEQAKEEETMEEEEKKEEETIEENKIEKLKEENKFEDEEEEKLKEEEEKLKEEKEDVEDKKIQKEEKEKEEMKVEEEEEFKEEKEDVENEKEEEVKIEKNEELNVEDCKTQENEEKKEEEKLGEEKIIKDFKTEKEEEKLGEEKIIKDFKTEKEEKKEEEDIKTHVEEGHQKKEKAEDKSLKTSKSEKNEDLVVEKEIEEKDDNNKKVEDMKVENKEEKNEEDMNVGDKNIEDKNIEDKEEKNVQVQNVVLKNEATKEEIEEKIKEEEMRIKDVNFETKENLKVQKEIENLKEFNIKNLVSDESVVELETEKCLDLDFKEKSCLSSKEKQEENKNNEFKDFKSKENLNTEKDFKSNENLNVKKDENNLNIEEDESNENLNTEEDFKSKENLNIKKDENNLNIEEDESNENLNTEEDFKSKENLNIKKDENNLNIEEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNN7</accession>
    <name>A0A4Q9LNN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2086p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002086">
        <property type="protein sequence ID" value="TBU09944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2086p0010"/>
    <dbReference type="OrthoDB" id="2195102at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="35319" checksum="5107F8460B31DE7B" modified="2019-07-31" version="1" fragment="single">MERKESQEKRKRVSFAPEASINFYANEVQQNTKSTSSNEDLSILNENEESLSLTCAAIPTSDDGYNFYSKIEEEKENKNFEEKFNEEGNFMEIKSSFEKIGENNDELNKSIEKIVDDAIRYNIPLNEINIFGESIEKIIEKEKIIEKEDQEDLKMNTKDFSFLNNNFMTETINMREIIDTQDLRKFIPENKNEKINFNDLLVSHGIRFLDKMIYNRGRRSTISKSKNVVTPNLKNYYKFFKINQINFYENFIFDLERLNEEQEKTNENLENEFKIKGSLLEDEDKDKHLKMLKSVCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNW2</accession>
    <name>A0A4Q9LNW2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2129p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002129">
        <property type="protein sequence ID" value="TBU09666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2129p0020"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17380" checksum="262A7F3B99468A93" modified="2019-07-31" version="1" fragment="single">IRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVKTEKLRKYDPLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIHFSHHAGSRNDLVDQSFRLRSVTARMNAHIHSIVLKNTVKIIFFDRRRGLEARRNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP63</accession>
    <name>A0A4Q9LP63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subunit alpha of sodium/potassium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1942p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001942">
        <property type="protein sequence ID" value="TBU10208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP63"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1942p0020"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="562" mass="63263" checksum="A66F00C244380654" modified="2019-07-31" version="1" fragment="single">MIPIPQTSENTNKEMSKMDKTHIPMEQTSHISQTQSKETNEHTISLEELFIKYTVDPDKGRTAEEIETAKLNFGENTFSKPKKDFVGLKFFKIYFQSFNILLTIASFMSFTIYLLNNKLILNLYLSFTIIIVCLLNTLMEFYQEYKAAEIIKGFNTLVPQKARVIRNGVEEEIFASEIVVGDILLFKLGEKVGADCRLMYCNELKVNNSSITGESVPVLKDTEISRSDVLHASNLVFSGNEVVSGEGKGIVIKVGNNTILGKIANLTVNKKSEKSQLTEEINDYVKKLGCIAFITSFIFYIIALINGFTFVDNLSFCIGVFIAFVPQGLPATVTILLVIAAKRMASKNVLVKDLRAVETLGSISLLASDKTGTLTKGKMACNTLWINESSYSILKYKSDSKETKSKKDKNERYLEIQNDIQSENISNLDSNTTSTIKKEECDALALESINLNVKNLKELIKICCLCNNAKVNNKNKIVGDPTETALMNFGLDYMNKISDLVMDISRIRENKLGEIPFSSETKLHVVVYEEEENFIVYMKGAPERILNYCSYRRFNDSDLKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP70</accession>
    <name>A0A4Q9LP70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1941p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001941">
        <property type="protein sequence ID" value="TBU10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1941p0010"/>
    <dbReference type="OrthoDB" id="2193787at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="30348" checksum="0C5A4261A024C52B" modified="2019-07-31" version="1">MFFGDPSKEEIDLYLSDIKYSLINNPNLKNEIITSQKSFGNKKIERKNNFFDKIKAYEFTEPNVCFKNIKMNFDIKKTSNTSVEDIVTQDISSEIIEKMEKEFSSRRKSKKKRKIFGNSRNGILQPKNLNVPFRIDKSKIKEIRDLTRKNTLKNTGYKFVRLESKLRTVFYSYEDFEHEKNKNIEDFVFKKRKVRFIDRNTNRLYHNEGDPIPIILQPKEKTEFIEPDTIETVFIENILTIPRKVSAGEFIFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP79</accession>
    <name>A0A4Q9LP79_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DSHCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1933p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001933">
        <property type="protein sequence ID" value="TBU10219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LP79"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1933p0010"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="110"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="525"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="769"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1386" mass="156202" checksum="D0F863DF48540FE6" modified="2019-07-31" version="1">MSFENPDDPFSVFNTITNTSNTYDAYNTYDAYNTYDTIPNTNTIPNTISNTNTNITNTPITNTKISCVTTYQHTRHLAVTPLSTTYIPLTLTPPSKIYPFKLDTFQLLAINAIERNESVLVSAHTSSGKTLVAEHAIHTCISNNQRVIYTSPIKALSNQKYRELLEKFNDVGLMTGDVTLNPSSSCIVMTTEILRNMLYKGSEILREVKYIIFDEIHYMKDKERGVVWEESIILLPCSVRMVFLSATVPNALQFAEWITYIHQQTTHVIYTDKRPTPLIHYIAPLGEKGMTKVCYNVDCDSDSKGVGYEGDIASKGVIDSKVCDYKGDIDSKVCDYKGDNYKDSSYKGDIDRGSSYKGVIDTDSKQQGVNYKDSSYKGDIDRGSSYKGVIDTDSKQQGVNTSTNKQQGVNNLSNKQQGVNISTNKQQGVNISTNKQQGVNNLSNKQHPSNPTHTHTTNPTTTTPTNNNTFFDRKAFTSVVKSIKRSKRIESKNIFQITETLIQNNNLPAIFFSFSRKDCEKHALSIEQDFLNSEEKKMIKIIFSNALSTLRTEDRNLPLITNILPLLMKGIGIHHSGLLPILKEVIEILFQENLLKILFATETFSIGLNMPAKTVIFTSLYKFDGILKRILSSGEYIQMSGRAGRRGLDDKGIVIVMLGDTIEEEEGVKLFSGICDRLDSAFYLSYNMVLNLMRVEGLDPLFLLGRSFYHFQNIYKREEVFKEIKKIRHIIDKYEYECGGGSGSGSGGCGSGECGSGDSGSGDSGSGDSGSVSSRDSNIHNNNTTNNNTNNQLNNNTNNNNNQPNTPIINQLPLLCLERERLLIERSVSLQEVFKPYLKVGRLLNIFIPREGATLFINAIIITGGDGSRGSGRGKGRVNNNLITNPISITNPISNSNPISNNNNNNPITNTNTNTYTTNHNTNTNTNTLSVHAFMRGGIKRMQINKTCINNIYDIRVKEDFIFKENNKIPFINIKSEYDYKIYEIESEIESISKGYESESEIESISKGYESKGYESKGYDSISKGCYLCGREYIVSKCIEGICYDPIAEYDSMDSMLDSSIRDRDSICNRDRDSSNTNTSNRVRDSIRYDNTNTNKTSNTTNTNKRSNTNNNNIYTNNNLYTNTTNNNIYTNNNLYTPTSTNTNNTPTTPTPLILLKHFRLLYSKNLIIRKYNTLNSLNEIYHMEDCKKMISVLRRLEYCDINNKVLVKGRVACEISSSDELILTEMIFNGDFISLGVDEIVPLLSCMVFSEWEENNDLELSEQNNKTYRLLKGTVDKISKVMSECGLYVDIQCYYKRFSYELMDVVRMWVLGFTFSEICCKTNVFEGSIIRCFRRLEELMRQLSCAARGIGNSELEGIFSLGVSKIKRDIVFASSLYLDIVLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPE0</accession>
    <name>A0A4Q9LPE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1844p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001844">
        <property type="protein sequence ID" value="TBU10333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1844p0020"/>
    <dbReference type="OrthoDB" id="2426083at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="411"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="672" mass="77058" checksum="14A1EF7439495EB5" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSKTLKNNKIKDANDADKVKKSESGIQKCELHPLTISLTSSSYTKTTHPPLRQTFSNMQNIPACEPSYDMTNPCTLAIPEGNRLMALRTIFDFVTADPKESPRIVFFGSTDKLHTYYNEKFGRAETLEEVKSEENGERRRIAACLADTCTLTDTNDKIKEISEKEIEKVVVRTRKLPSELVESKLWDLINRIIGEYADSYVPMTITAVARIIQAAQVCYDEATRKEKPRYAWKKNIEIKISKLVLSKILLEKARKQKKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRDRFYRGLSERVESEHVVSRDEIVSFWSTMWSKNDDKVTYDDYSFHLYQIIILPPAGIDGIYNFFILKLTTLHKYIYDIVKVICLEGTPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEGAKEQVLLNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLIEGVSVYKYLGIIEDSRGIPTRSSFEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ80</accession>
    <name>A0A4Q9LQ80_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2123p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002123">
        <property type="protein sequence ID" value="TBU09721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ80"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2123p0010"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU09721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="94644" checksum="C71EA2165FB21803" modified="2019-07-31" version="1">MENIGIDIGTFKTVISSSHEKGRIIYDELSKRSFPTAIQLTSPKRRFGNLVIQSRIKINKLFTTDLTDQHNLTHTNMFLQYCRRLIAHTTPTTNITLSIPYTFTDIHKRTILSLFSHPTSTVTLIQDTTATALASLLKIEKKSKFLNIIDLGYSKTTSSSFTLTSSLTPIYLSGIPIGSKDIDKATLSYLSIKYPSIINHTHRIDIDYMKTLLNSTPTVQMCIELPETSQNIEISQQEYEEANKEVLLNLEEFFFNYQQHIIKTSNSLEDDEDIEGGVNNNGSKLEGVNNNGSKQQGVNDTTNEQQGVNNTTNEQDPVNNTTNEQDPLINNNNPSIIVVGGNSNNYLIRKILTKYFKVSFNLNADESVSNGSAFSTFFYSPFSLSKVTYKDILYNTIFIDNQVLFKSGTLIPSPPLKVTYKKKNNFSVFLKDNNDKIGSVSVFLKEDKTVEVSLFIGLDRNGIVRVEKVEINNKEIDESKGSVCGGENVENVCDNIEDNSNIKDTNTKDNTNDKDDGSIINSYKFEVSGLNQDYIKIALEEELKCRKKEEEYEIIGNMRNGLEMGIKKLLQRIEVLGVEGEGRGMVGVVEEIKEDLGFMELSGSVEEENKLNEEIRIKLKNVDNLLRGIEEEKYKKINEILMEAEGVVREAESVKGDVGLGLVLYKLKGGCFRMRKVLSEFENIDVLFGETVDCRIEKEVREMIGKVRSEIIRRKEEIERERIEREKEEREKKEKKDSESMEEEGRKDGERKEEKGDKQNIEEEEKDQPTTEVENMEGEADCVIVEEVIEEVTVEEQGVNDNKEGIENKTFNDNNFIKEDQRKDKKVKEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQF7</accession>
    <name>A0A4Q9LQF7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1607p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001607">
        <property type="protein sequence ID" value="TBU10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQF7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQF7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1607p0020"/>
    <dbReference type="OrthoDB" id="2193051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="33814" checksum="E339340B8AC2A3AA" modified="2019-07-31" version="1">MGTNRIHIYKKSNKRIYKWLINTFILFVLIIFQLTFILFVFQNKFIYKIKKDDFEISEYTETKYLESKDNNLQLYYINNNSDTDIYVFHGSLVSLKVHQLICKKMCGKKYNLITFFYRGYNKNRGKCNEVNIMIDTYVLYKYVSMCRSKNKKIIFGQSLGCASALYFASLFDKKTDLKIILENPFYDMQSITKNSWFFKIPSFILHEDWPNHLRINNLININLKILFIVSEKDIIVDNQDSYKLMEINKKIKTDIYVLKGATHFDCGKFKEFFITVDNFISKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG1</accession>
    <name>A0A4Q9LQG1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA primase small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1587p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001587">
        <property type="protein sequence ID" value="TBU10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1587p0020"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="33690" checksum="8C543BF83C8D0FFD" modified="2019-07-31" version="1">MDDQAYSMLPYFYENIFPLERIFQWLKIDEKREISFTLQNGMYLRYLNFKSKEELQTKILSTVPVKIDFGAVYANRLRKGTECIPVEKELVFDIDLTDYKRICCTGRNTCETCFVLVKSAIKLLNYSLKEEFGFEKVLFVFSGGRGIHCWVSDDNARSLNNSERQSVTKFFDSVSKRKIFPTEYCNILMENISYFNEQDLNIKPETATVEEIFEHLYIKLDKNVTSEIKHLLKSPFCVHSSTTKVCVPLDPENIDTFLIEHLPTLQNVMDNPKTLDPYIRIFDQIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL7</accession>
    <name>A0A4Q9LQL7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase TEL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATM homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">DNA-damage checkpoint kinase TEL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Serine/threonine-protein kinase tel1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Telomere length regulation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_1621p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001621">
        <property type="protein sequence ID" value="TBU10664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1621p0010"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="399" mass="46862" checksum="61D089D275C6D02C" modified="2019-07-31" version="1" fragment="single">ELRQDIIALQMFSQMNKVFENKNILKIRTYKVVRFEKFFGIVQYLSNTITLGELIDNLHKKKYPEKYDLKKCRNIFNSVVSHSLDSKISTFKEICENFIPVFNNFFLNFNNPFIYFRMKRKYVQSLGISSISTYILGLGDRHCHNLLIDTYTGEIINIDLNLLFDQARLLKTPETVPFRMTRNLIDALMCKISLNTFKTDSFKNENYFSNSSISKENEVEKIKRSKLQETESKTLNHKSNDNDSLENEVEKIKRSKLQETGSKTLNYNSNDNDSLENENKLYNLREINTRNIYLQEIMTQTLKQLKKEKSIILSLMTIFRSDPLHRWILCDKKIGNIGKKSDIKLFTDAEKIIFRMKEKLSGIESGFCFSEDSHVCFLLEKATSVENLVKLFPGWQPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX6</accession>
    <name>A0A4Q9LQX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1635p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001635">
        <property type="protein sequence ID" value="TBU10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1635p0010"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="3"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="154" mass="18864" checksum="21AC2C63F8542318" modified="2019-07-31" version="1">MEISEKLNICLRSVQIWFQNKRAKLKKDMRNDTAAMAYINDGRGYNANIVPSNNSLYTLRENILNNRPFMDDLYQCRYENNIFYKNEMMPNSDFNVTPFFRYKRHYKFHDCTNDQRLFYNKKKLNYEKECEHKETDCNCYLFTVENKNSYFNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR05</accession>
    <name>A0A4Q9LR05_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-c protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1717p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001717">
        <property type="protein sequence ID" value="TBU10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1717p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020279384" description="Fam-c protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32966" checksum="6954D71C832A4FA0" modified="2019-07-31" version="1">MYLERNIKCSNRLLVIVFIALCLNRICGNDITLDITGKSKCDTISNSNEKDNSVFRSRIAENVERRCIQGGEIKKLPQDITLNRNPNFDAKVKKINRNIYRDMGHLSNKKILSSDFMERKKVFENPSSTNPRFICKQSYITPFGKRVFYKKESNVTGNSTCEQNTYCDLKKEENISQKEEKINNQFEQIKLTSKTGNTEQKIFSQKVAEDEEITNQKNEKNIEVTKQRRIPKNKGYRVQENEFASFMKALKNHIEVFRKVPEFEEKYSEELKQKSKETKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR09</accession>
    <name>A0A4Q9LR09_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1462p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001462">
        <property type="protein sequence ID" value="TBU10949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR09"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1462p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020356330" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="70636" checksum="9675A743DB549815" modified="2019-07-31" version="1">MIFFLFLYRVFLTSPLVSNGPFRLTVANNENLVLTSHNASVRMKDIATATGVSEVIMEKADPQSSDMYRIRIGQKYLCKKPFDAGVVACDTMDSNSVWKVETGPGGFVMRNERACLVKAAQDNNTKLGGFYLNTKDCNDQNSEKYFRFVPTQTTQPTVVYTPPPDATQQVQYSNVSIGQSPNGSTVITQNSSVIQGDNTIEDKTVVVQCDDQPSGCEQQPSYTYSTVPQTVPVYEPQPVYESFNSVNIQPQPTAIVEAPVEPVYVQNFVPSAPVPPPVVTHPIPRPMPVPRNEPAQPQVIIPRIEPSVQPVGPPVLHPIQRPIPQPVMQPIPQPMPQPVMQPIPQPIVQPIPPPQPQPVMIPIQQPPNIQPVNPPFAVSAPPQQPTPVFRPQFVPQNVVEQRPEPSQLPLIVQKTLPTPPSQCVVAPPSSQQPPIQWPIQLPIQQPTLERQIGFTLPSPKENKPSEACIVEPIPVNFGTNNFKMSYLPAPQKNISDLYTPCHAGMQGCESTNKVAYVNPQQPRIVPSVSKSGCDAVLNSALSNVPTFVRNSNECEVTSNNFTESPLVVNDNKSITGVTGCNAGVSACEVVKTDPLNVDHMPTLEVRKGCEDQSACAEINQPGKVSFTEDANPNGYIYIHGVPPVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT6</accession>
    <name>A0A4Q9LRT6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI37_1377p0020</name>
        <name evidence="20" type="ORF">CWI38_1353p0020</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FI-OER-3-3</strain>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="EMBL" id="PITJ01001377">
        <property type="protein sequence ID" value="TBT99342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001353">
        <property type="protein sequence ID" value="TBU11154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1377p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1353p0020"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBT99342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU11154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="194" mass="22783" checksum="AB8B120CDF25D1CD" modified="2019-07-31" version="1">MKYSALFFIPNLICYLRFILLIVAIFFEKSTFILFYSISAILDALDGYSARKLNQCTLLGSILDMAIDRISTVIILIKIGNNIPTLTPYLSVCISIDLLSHFLHFSSSLLQSIHHKSCKSKILEIYYRRRILFLICFFVEMFYICCYCTSFISRMYFFCIFFGIFWILKTFLHFIQMINALKELAIISKQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV6</accession>
    <name>A0A4Q9LRV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1884p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001884">
        <property type="protein sequence ID" value="TBU10275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1884p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="50" mass="5759" checksum="FD5D8F4AED04C8E0" modified="2019-07-31" version="1" fragment="single">MISYTNCISNINVSWITMHLMGRIVYGAMKKGSELTKEWEEDYKNSVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS28</accession>
    <name>A0A4Q9LS28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1218p0030</name>
        <name evidence="2" type="ORF">CWI38_1246p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001246">
        <property type="protein sequence ID" value="TBU11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001218">
        <property type="protein sequence ID" value="TBU11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1218p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1246p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10715" checksum="3B8E28FEFAE5A8EF" modified="2019-07-31" version="1" fragment="single">MRSKGHKNQSKTKKKKNGIPNPYNRIKEESHLTEDLDLKCIVSICQDNDLEDLKIFFSRSYIYLDYKKLLKLFPKHMSVSKIETLDSEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS43</accession>
    <name>A0A4Q9LS43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1288p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001288">
        <property type="protein sequence ID" value="TBU11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1288p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="357" mass="40734" checksum="468708224343C059" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKRSDSEVQKCKLHPLAISLPSSSYTIITPPPPSQTCSKMQNSGLDTLPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGMEVKSEENGERRRIATCLADTCTLTDTTEFINLRDKFLSKIKEISEEEIGKVVVRTRKLPSELVDSKYADSYVPMTITAVARIIQAAQVCYDQATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQKKLSTSETKSLKKIMREFNLNLSSVTDLSEVLVKKNESLNVYEKNTMYERRKRFRKENRMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS52</accession>
    <name>A0A4Q9LS52_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_1704p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001704">
        <property type="protein sequence ID" value="TBU10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS52"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1704p0020"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="14">
        <location>
            <begin position="359"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="515" mass="60026" checksum="B96570D6D7CE67EF" modified="2019-07-31" version="1">MKIKIALIVGYVGTEYNGLQYNIYGRTIEGEIIKSLLSIKAITEMNAAVPRKIALHRSCRTDKGVHAVMNIIVCKVVYKIENEKFEELKNDLLSKNIYLYKIVRVTKGFDAKKMCQARTYKYILPAFILKEGNFNEEIESFLVHCRSQKNILNLESNNSTLEPNLNKKCVLDNEGYDKKTLDASYSKNNRINELSLFEDSLSNDTNSSNFLEEKNVQFQTETAKDNPLITDSSQNKLKNEILNINTANTSSEKRFKEIVIENKDNISAQENEIFGIGSLEEKSIQTNEKFCIEKEDFIGKDLLKDDSIQMNDNFGLEKDDLISNDLLKEIFSNDLNYKITEDDFNFFELTFKKLIRNCDFHNFTTTKNTKGTRRYIKDISVSKPFLYNDREYIEITIHGQSFMLHQIRKMVGFVILITKYCRNKSDEIINMAFSSSKINVPKSPAEYLFLDTPFFDFYNKKFGKLYSEISLDESEKSKFKEVYILPNIHNEENIISLLNWIRVIYKHGYHFEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS62</accession>
    <name>A0A4Q9LS62_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_1829p0010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001829">
        <property type="protein sequence ID" value="TBU10350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS62"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1829p0010"/>
    <dbReference type="OrthoDB" id="3240828at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="18">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="17">
        <location>
            <begin position="51"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="16">
        <location>
            <begin position="337"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="15">
        <location>
            <begin position="664"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU10350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133396" checksum="EE2B3F0ECAC1B857" modified="2019-07-31" version="1" fragment="single">NISQVSGCVGQQTVEGHRIPYGFRYRTLPHFLKDDTAAESRGFVQNSYISGLTPAEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKAMEDASVKYDRSVRNGRGVVFQFLYGDDGYDATYLENVEIKGVRGVEGMLEGDSRDKGMLEGDSRDKGMLEGDSRDKGMLEGDSRDKGMLEGDSFSIDNYNPVSNSIDNYNPLSNSMDNYNPVNNSIDNYNPVSNSIDNYNPVNNSMDNYNPVNNSTYKQQGVSNSTNNYNPVTDSTNNYNPVTDMTYKLEGVNIEDSNYNSTNKQQGFNTSSSNNNTNTNNSTNNHNNNNTTNHTNTNNNNNILNLALKHKIDMFGSKEYRIISKDTSYYNMLSTDIELQKILDKEWEEIFKVCCYLKEGRYALPVNVKRLLWTARVKYGKGSVNPYKIIQVREDLIRFINSNGIGYMGDSKDSSVVGGVSKEYDYMGVNKEYHYMGVNNTTDGYNPVSNDTNNYRGVNNRDSNYNPVSNDTSNYNPVSTNTSNYNPINNPSNQHPSNIHHPSITTTGSNVLACLIRISLSTKKCILKHKLSLEGLEWFIKQTKSKFINSLATVGEMVGTLAAQSVGEPATQMTLNTFHYAGVASTVTLGVPRLKEIINVSKSMKTPSMRVFLNSDFSSNIKSARIVQNEIEYLSIKDVIYSIEIIYDKEIESSVIEEDIDFIKVYYEFPDEIINNSLLSNWVLRITLNRESMVSKGVSISNLESVIKKAFGSDLQVICSDENAEVLIIRIRVYGEEDECFLKKVCENIMELQLKGIKGIKKAFLLNYKEEWVLQTEGSNLWEVLYHKWVKGFKCYSNCIIEVVEVLGIEGGRECVLRELKGVIESDGSYVNYRHLSLLCDVMTLRGVLSGITRHGVNRGDNGALIRCSFEETVEILLEAALRAENSVCRGVTDNIMVGQMIPLGTGNMDLLVDLECLKEAIPLIKGVFDFEKVENEYLDVKTPEIMSPVSEVSGSPVGGCWSPVGLMSGGSYYNPGSPLCGTASPSYRSGFVSSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSRAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPKSAFTPNIPVLTPGSVMPSPALNTFTPVVPDLLPGNEGTYSPDRGGVEDECYSPLNTRKSNKKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK0</accession>
    <name>A0A4Q9LSK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1203p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001203">
        <property type="protein sequence ID" value="TBU11444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1203p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="24072" checksum="5DB3954547D1BB71" modified="2019-07-31" version="1">MDGRFKELTLSNEEDENICVSKESINTYFYYFYDLILDVPQSKHELTDILLKYLDNLMNLSNLNKSEMKKNILNFTEKLKRNYKFTCLGKFKDENETLQREIKEIFKKTAFIKNKDLKDQNLKIIEIEKLLDIFDKISDKEDFSFGVNIVKESLKDIFNNPKYKDEYKRKIDGYIIVFYSYIEKKEPGCKNILEDIIKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ3</accession>
    <name>A0A4Q9LSQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1659p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001659">
        <property type="protein sequence ID" value="TBU10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1659p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="622" mass="73349" checksum="0B0CA9C687161607" modified="2019-07-31" version="1" fragment="single">CLSLLKATKNKDYDEFIRALIYKNLISKNIDTIFKQESLARIDVSMKKDNFISAVLDFFMIKYDFYDGNLILLDKKKDIYDVKNFDKHIPYKNLFFNSFKIFCRLEIILGNFYASNLFIILLNELNIKSLIISNKDNYKILDKQFNFHILSTKIFKSIVIINFKDISSLLFLSKLNLAIPNNIEFLSFRNLVVPVNILNSFLESRKLIGLVLNEMKFTGAFPFIKDFYDSNETLEYINICYVDINSTCWNNFFSRTNVRKIILSFSSSSAEACFLKEFYASAPYKSVRYIEVRFHRASVISKKILEFLKHFTILELLKLHGYIIEKNAEFHIPNAIECMKDLEYLEISQLSYNPDFYNFLPGISRISVLHIYNVLLDKEASLIDFIKNHKSLTELDLRETIITQSCLQEIFRLEHLKTFIMKSCVLELFMDDLLLEFASKRLNTLCLSRIDSNYTKYFNFVTKLDCLEYLEILNNKLLPGYVPNLSEKYNLSLKKLSYISTILDEDIMNRMGQLEVLNELYLSKCSFIYTHFHKLGNFCKFFNSLKILDLSCVELNIEDLKYIKNFKKLIKLSIKMPDFDLIPLKNCLIFLPICQLQIFYGKQKGNYDIIRKYLFEQNFDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW5</accession>
    <name>A0A4Q9LSW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA polymerase II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1314p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001314">
        <property type="protein sequence ID" value="TBU11226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1314p0010"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="5">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="33641" checksum="1B503565D05913E0" modified="2019-07-31" version="1">MEQLIYAIKNIEKCSIMPDEIIIDGKFYKRNIPVHLKTKLKRTYTLCEILFYILNKRSTSAEYLRSCNKNNISPIDYTDRKLLNDEINSYCSFDESNSVLDEIESRYICNKDFSYIFDILKNLENKKEEKIVLIDTFRIIVPSSVKSLITVNNVKDFLEKSKFLESNLEDIFCSSSKCTVSIDGVQFDVHDDVKSFTSEDWKSVVAIFVDGSSWQFKNWKDKNLAEIFCNTAVFFVRYDNMEMASEIQGYNIENVVVDKKNKSLKKEDFERIRRDILKVVELKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT21</accession>
    <name>A0A4Q9LT21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1606p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001606">
        <property type="protein sequence ID" value="TBU10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1606p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021014899" evidence="1">
        <location>
            <begin position="20"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="663" mass="77743" checksum="EEB3797DA9663F43" modified="2019-07-31" version="1">MNLNFSLFLIHIYFNAVEASPDRKKVKISDHEENSFKNHETLAIIDGIDYLGFAKIFSHQSKPLKSSNPIEGAISSDRREISNATGSDSKTYIDEPQLTELDTKAQEEYSLTFQAFSAKRFYDQKFTEADSYEDMSQKGSQLEFSFDDVSSYMELNSTEKVQEFHCEIYPNDFEVNRSITSGTNTNKTSLSIHQTIGKNNAVNDSSKFDLEFQSKDTNGSDNWKEAVNKLFIKGLIENSGSNMREELISIVKDELEKKIEEQDRQSDVDSEEEVLSCLKNKESKFYCNKFKSNSDFKEILNFGRRLVSFEKNSYSNLSTSEIMQKIDGYHLINYANELRKTKIHLIVPELNYLLDSFEENIIDNILHGNALLIHYYYEITKIIINLILTNSNKVDINIIRKNSRGNEKMEGKEEKSGKISKEEKKKKTLDESEEVRLLDIRRIFFIKRLLSELFPLFQYDSVKIEIYKTLNLLYFISHFIHLSRSYLRKYFFRYKMNFLFRFLFDSNIYFKNDFNKKFIEDILGENENGTNPDLFIKNKLTALFRDYFCLDIFFYKGIAIIETYKVFAIAKDKDKLRTKTNIIAKLKKDSEQNLLENIDAYKNRKIFIFLKLEFKINHSEYLVLSTTISIMNFYKSRGPCEISKKLLKESNKSLEELKFNKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT25</accession>
    <name>A0A4Q9LT25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1053p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001053">
        <property type="protein sequence ID" value="TBU11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1053p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="267" mass="32475" checksum="8F44B55A30AF253D" modified="2019-07-31" version="1">MKKQILDRLEKEIEIFLKTNNQSVTIDTIYNEVIFKRINVFLKHIINIFMSGYKKDKKRLQFFSFLINEVSSKNDLENMNSKFQYCEDNLPNYRGYLEQNRLTNYFFLSLRSEESCEIKIISTILIQDLKLILQKIFRHFENYQDMLSYFKDNDTDKLKSKYVKKTDKYVFYEVNNTVFDEYFFKHVFDLIFEKTIASNSFLIKYILSYNDEEYINERKFIDETWNLTTENHLFLDAEINPEEIGKNFGSFLRNNIKNTKNFNNYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT74</accession>
    <name>A0A4Q9LT74_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1551p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001551">
        <property type="protein sequence ID" value="TBU10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1551p0020"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17808" checksum="B0ABA41C59CBA8E9" modified="2019-07-31" version="1">MTNADILNELIIIYRNEKNIKTLLPYQTSIIETIYSLIQSQQTYLNALKKNQIIKNIIEQELDTAKYFLKEYLKIRIKKLQIYFLTSKDLLSSKEIIFQEKIVNLYKEKNIYVESEYKNTEYVGFICLKDIKQIFLDKNPCMNIFTITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTM3</accession>
    <name>A0A4Q9LTM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1386p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001386">
        <property type="protein sequence ID" value="TBU11101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTM3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1386p0020"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="566" mass="67287" checksum="42405F807D385133" modified="2019-07-31" version="1">MKYPIFYATQSGTSYFISKTIASTLNNGFDRCSVAKSMNERTFEPFSINNFDITKIIYLKLFIIVVPTYGDGDHSFELFKFWKIISMEEIPKIFKNKYFAVFGIGDSSYEKFNYSSKKIYNRIISLGGIPLIRRGNGDIGADNGYNSELKNWMFELMNNICNIFTCFSFTYGLDETKVDCLLNLNRVFKDFQCKNLNEINFDLFLETNTKYKSKVIHKEYLTPSDYDKEVLEIIFEINEYTGYKPGCCLEIKPTNYNYLDFIKYNNFNGNEMIEYKNTKISVFKLLREIKDINFVPQQLFFYSFYTEIKEIYGDNKLFKSKYNKNLECKEIIERIKIISQDYDLYHDYVLKPKRTFFEILIDLELKVSLNFVKVYVPEILNRYFTFEHKKENKYSIAVSLIEYKSIIRTKRYGLCSKYLKDLSINSEIFIGITESNLHLNGNKFLVICTGTGIVVAKSILNYFKNLEMIIFYGFRFLEKDFLFRKELFENNELNEKWIKNKNLKMCVALSREMDRKYVHKIFEEEWNGNIEEYSVILAGNTSLNKEMRKTFLKMFNKNIDFQSETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTU5</accession>
    <name>A0A4Q9LTU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1444p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001444">
        <property type="protein sequence ID" value="TBU10990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1444p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020780044" evidence="1">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="281" mass="33079" checksum="EAB8EC05898D48CE" modified="2019-07-31" version="1">MYLERNIKCSNRLLVIVFIALCLNRICGNDITLDITGKSKCDTISNSNEKDNSVFRSRMAENVERRCIEGGEIKKLPQDITLNRNPNFDAKVKKINRNIYRDMGHLSNKKILSSDFMERKKVFENPSSTNPRFICKQSYITPFGKRVFYKKESNVTGNSTCEQNTYYDLKKEENFSQKEEKINNQFEQIKLTSKTGNTEQKIFSQKVAEDEEITNQKNEKNIEVTKQRRIPKNKGYRVQENEFASFMKALKNHIEVFRKVPEFEEKYSEELKQKSKETKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU03</accession>
    <name>A0A4Q9LU03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1393p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001393">
        <property type="protein sequence ID" value="TBU11085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1393p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="16681" checksum="C1FE89C16008639E" modified="2019-07-31" version="1" fragment="single">KCNVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESSPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU85</accession>
    <name>A0A4Q9LU85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1367p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001367">
        <property type="protein sequence ID" value="TBU11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1367p0010"/>
    <dbReference type="OrthoDB" id="2194678at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="260" mass="30187" checksum="1B212C38064D8499" modified="2019-07-31" version="1">MSNSFSGKNTGENKYHFHVGQTLEYIECENDNGSVCFVETSGSRNENLSLTTISTPRKQIVSNNDLKRTIVKTMKGHLMRLKLTLEIKECLETYFDLEGIKTLLPLHSKAVKLVPEPQDQLRNCFRELVVNYDDKNFVFLNKVGRAVETRPSRGCNKRGESACLSYFGGRSNEQICMIYHKTYERIVNEKNLKLSNKEIYESCKQQKILTSIFVMNNARISHNRGLNEDEEIAWYRIKTYHLTLYFLIALRMYSRSGKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUA2</accession>
    <name>A0A4Q9LUA2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase TEL1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATM homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">DNA-damage checkpoint kinase TEL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein kinase tel1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Telomere length regulation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI38_1355p0010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001355">
        <property type="protein sequence ID" value="TBU11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUA2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1355p0010"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="466"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="19">
        <location>
            <begin position="867"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="899" mass="106160" checksum="B08CE7F101C4D4B9" modified="2019-07-31" version="1" fragment="single">KEQNNNLYKNCIFIDKFQVQNENIFSSNISIKNENMNYLSPEHFNSKFKNIISTLSDSFTDYFNEIEKTFCKIEKEDSIKLLMTRDETFNFLKSFLFYNLNMFDESKKYLNEVIKNTDFNHHIFYIANTNLADMKIKTYEGKPIEIITQYLIPCLKNLNIIENEMVVPFKSNMNKSKTGKLFVPNEKNTNIFTIPENKDDINFNPIYFAKDSFFEFKILVLEKIGNILYEIYEGFLNSLSLNTNLEEKNTKIEKSKMNLLSDYTAEIAFQKEIKENRNELFLKSYHLLLRIYSELSLISDKDSFIFKLLSIIFDFNGKNSKILENIPSYKFLPAKYQLISKYFNSDSEYLKKTIYRLCNDHFIHVVFEVLCSIKNKMDIKSMDTLKSKEKGTYERFTSSSEHFNLFKNNIKNVKNIERMIESYKCIYRNEKNFNEDISFKEIPIPSINFKISKNSEYKNLVFFEEFILSVKKLPGINNPILIENRGSDGKIYKEIIKGKDELRQDIIALQMFSQMNKVFENKNILKIRTYKVVRFEKFFGIVQYLSNTITLGELIDNLHKKKYPEKYDLKKCRNIFNSVVSHSLDSKISTFKEICENFIPVFNNFFLNFNNPFIYFRMKRKYVQSLGISSISTYILGLGDRHCHNLLIDTYTGEIINIDLNLLFDQARLLKTPETVPFRMTRNLIDALMCKISLNTFKTDSFKNENYFSNSSISKENEVEKIKRSKLQETESKKLNHKSNDDDSLENEVEKIKRSKLQETGSKTLNYNSNDNDSLENENKLYNLREINTRNIYLREIMTQTLKQLKKEKSIILSLMTIFRSDPLHRWILCDKKIGNIGKKSDIKLFTDAEKIIFRMKEKLSGIESGFCFSEDSHVCFLLEKATSIENLVKLFPGWQPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUE7</accession>
    <name>A0A4Q9LUE7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0824p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PITK01000824">
        <property type="protein sequence ID" value="TBU12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0824p0030"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="25992" checksum="79E721D2495E0B51" modified="2019-07-31" version="1" fragment="single">MGTFILKKDLTAIEKLGIGRFWQNYLVHFCGLNEDKNIFFEMRVMKKKKIIELNEEGCIKEEYKKRFAIRCMFLMNVISTFQDYEYLYYIQELPRGGFFYYYLRSSKKFTKEVSKFYFGEMVLGIQYLHSKGMFFRLLSPDNIMITLDGHIKLRFDFLNSIGMPFSEYEKNIEYIPIDYVRNKEFSIESDYWSLGIILFEMMVGSTPFAAKSYEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN1</accession>
    <name>A0A4Q9LUN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0967p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000967">
        <property type="protein sequence ID" value="TBU11946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0967p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="533" mass="62749" checksum="1292D686CC5F4572" modified="2019-07-31" version="1">MEEERENLDIKKAQKKLKKNLSQILHKRKKTNNFVSFIDLAINGTSVCKEYKSFICMNDYSSKRLFETCDTSRLTSGMFNRKLLCAFGINNVEEKIESREKMESRDELESNEDNKYNEYNGINKYKEVERREQNISFERKNNIFNSKKIENNLEIKVNNEGDNGFSKNTYNKDSINVNPFISLNSLNSLNSFNSEVKKDDKIYNLNRNLNQKNVSFFGSILDTEIKDEKEKGSVGGFGLFGREDFMGKDLSVNKYLNTLDNKNKEQDIRKEDISVNKYLNTSDNKNKEQDIRKEDLSVNKYLNTSDNKIKGQDILNKNLILDKSETFKNDKIKEKNIKHKDSISSPKRQENLSKVSSNDHSSGFLSKFTFYDSSDMPESEDKFVEIKNEISEDNKIGLVSFINRYSDNINNKFESSFNEIFNKELYDREKDDRELDKQDNREWDKQVKEDKQDNREWDNSSNMINITTTSTQDKKPEISFFDLLNTKKVENLNIKTELNFNEFKFEIGNLKHIIFKETPDFKFFYEDGTEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN8</accession>
    <name>A0A4Q9LUN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0783p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000783">
        <property type="protein sequence ID" value="TBU12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0783p0010"/>
    <dbReference type="OrthoDB" id="10663412at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21141" checksum="76A5B849C9B82A01" modified="2019-07-31" version="1" fragment="single">FSEIQSSKPFDQKNDFIETIPKNLNDIKNDNDYYYTLNIYNQIEKILQNKIKSVNFGTKKMDWFSEIIELILDLLVKENIFKNKVSIAEFPEIVTKLFPTAINEYETGNFYFDDKAIVGLDFSLILESSDIIHLFNEDNVNAILRNTAVIYFTKMHSFGNVNWKKMQDINNKGRSRTRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV34</accession>
    <name>A0A4Q9LV34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0716p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000716">
        <property type="protein sequence ID" value="TBU12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0716p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="537" mass="63750" checksum="A17FFCE5E949D377" modified="2019-07-31" version="1">MYHISFDIIFLLTSVFLDLSIYGIDLIPTLLLDTNNEEIYSYYNIEIQKENSILISKNLSRMFSNQNLNNSYSFKILLFFFLKKNFKTAIFRIIPLKNTSLWRLLLMILNSVDQVIFHKLHINKRLISFLNETDILKNLKTVHFWLAESNSNILSYIETILYAPNIFIEYNDCIQQSMYEKIKMKPLSIIKIVSIFIDCILNLPGIEILYLYDCNIGNYDEFHIYPKNYSITTFSFLGKKMINVNLFYKFMCSMIKLTNLEICNDSLSLLLDKDQNSLFSHIIHLNILDFCCVFKIYTNNNSFYFPFFISEEISVGVGFPAGTLKKIFSIQENLNIKKLLYSENFFDDSDSRALEYLNFLDSIELSSNIVEIRFHELFDINKTYKLKTIELKEMELNFQDIMFISSLNNLEILNLINCGFEKDCYRNIKGNDFKNLKFFYFEYFSFTKNKKIIKHLKEEFSSFKGARREFMARNVAMQALNEKLMKDQIKVLNLWADYFEGYLNEKTKKGKRPQLFEIGGYIFPEKRESFWRGSHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV45</accession>
    <name>A0A4Q9LV45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1177p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001177">
        <property type="protein sequence ID" value="TBU11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV45"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1177p0020"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="4">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="39460" checksum="85D0EA686A1367F0" modified="2019-07-31" version="1">MRVIERIHNVTNQKFSSNIDKTSSEIFKQLSGDTRNITLESLKIHFDETDSQEILNFFSEEKTNYDILNISRVSNINDDANIRSNNQIQIKKRVFSEKYSNLASNFNKLSLILIQNEKNFDKLRTILILVFIPISICIFYVSMGKKDLFRGYYMGVLGLILPMAFVFGPICSEILSCIIFVFFVRPFDKKDTIEIENEQYSVKEIGISYSTLISDSRTCNYPNEQLRKNRITNIRKSSYNVFTISKMFSYESFKENFDSLKTRIAKYLKEHPCDYKDEFYITDFEITKECHIKVNFILYFYISHDDLRIQEKRKDNFTLFLHNLIKELNIVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVS3</accession>
    <name>A0A4Q9LVS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1049p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001049">
        <property type="protein sequence ID" value="TBU11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVS3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1049p0030"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="19501" checksum="7F8C8D4692406710" modified="2019-07-31" version="1" fragment="single">LRSGTVPTPLVVGLGKAAEISKTEMKKDFLRIRKMANQLLEYFRKKLKDVTKNSVEDNLESDIENAKVYPGCLNISFSYVEGEGLLMSLKNIALSSGSACTSSSLEPSFVLRALGTDEDLAHSSIRFGMGRFTTEKEIKEIAKKTVDSVKNLRKMSPLYEMVKEGIDLKTINWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY3</accession>
    <name>A0A4Q9LVY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit alpha of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0071p0010</name>
        <name evidence="4" type="ORF">CWI38_0595p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000071">
        <property type="protein sequence ID" value="TBU04925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000595">
        <property type="protein sequence ID" value="TBU12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0071p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0595p0030"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="2">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="232" mass="26010" checksum="790B22810F3A1B6B" modified="2019-07-31" version="1">MVYDNALAVFSPDGRLIQVEYAQHASEQGSLVVFSTSKEYISVCIEKKGSNKMLVEDDEQKIVLIDPDQHFYMAYAGLSPDSYVIIEKARVICRNYKLQTSENITLTQLAVRLSGVKQKYTIQGGKRPFGIRSILFGFEDEQSKAYIVEPDGNFSGYRCGSIGQKSGKVNEFMEKSNESDPFLLTISSLSEVIQLNTSRIVSFDIYPDKIVKKSEDEIKSAVSGISERIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC0</accession>
    <name>A0A4Q9LWC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0555p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000555">
        <property type="protein sequence ID" value="TBU13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0555p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="243" mass="28741" checksum="328790D6516C274A" modified="2019-07-31" version="1">MIFDPEISFENVIDLPDKILVFNHSRNWPRLISTANTKLKLSGKLPKISCIEDQNTILKEKVMIFSQLEHDYHIKSFWRFKNICSEISHSDEPNKIIYFYSIMTFKTDFILECATSCTSSLSSELIANEHYIWHKTSTYAIIESLEFRKKITTDFNFSLYLSNESFEISSDHNLNITNIVDKVNKFEKDNYEFSFETASIDDFKKMFEEFDYEAININKVLVCRKKKSLSYKSQFKRDLNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE0</accession>
    <name>A0A4Q9LWE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myb-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0936p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000936">
        <property type="protein sequence ID" value="TBU12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0936p0010"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="1">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="352" mass="42196" checksum="C099C1975D11B54F" modified="2019-07-31" version="1">MTFVRFRRNEPISILCDFCYNEISFSTRIKCSECNLDFCVLCFYNKKILDGHDLSHKYRAIEPLVFPVYEPNWTALDELLFFDAFYIYGIGNWEDISNYFGSKSVEEIEKHFCLIFGISDNKFYESDKNISGFSNPNIHEVVNYLPLRKDFDVEYDNDAENIIKDLVFKEEDNEIEKQLKEAMIDSYFYTLKLRNIRKHIILDRNLYEIKKLQSKESNYSENEKKILSKLKPLTPYLSKTDFNSFLKGILIEEHLKSLLNKNQDFKQKYSNERFLKYEKERSKLLTDLELEICKKLEISYKSYIHIKSTAINEFLKNNYLNVKRLKYLLKSYDKRIEVLYGFFSKQGWIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG4</accession>
    <name>A0A4Q9LWG4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0922p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000922">
        <property type="protein sequence ID" value="TBU12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0922p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020193593" evidence="4">
        <location>
            <begin position="17"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="508" mass="59230" checksum="5D47976F9CE6CB70" modified="2019-07-31" version="1">MRYILEFLLYMWTTYAFVSSEEEYTRSDDESGNSMFEWKVRKPMFMSRNNKRVKVSTDEMFEEVVDKRDMSVRVFKRGCFTDSTVVYKPKYGNTAYILEVAHSENVDVVVDPETSVLSVNVSNKKFDVKPRVQLRAIRSNRIREINFEEGSDSEYNEESEGSDFRPVIPDFTKEGDKPEKEEEAGEAGVKRNFFLELNSDIREFPRNKILKANFGDADYYIHYTTQDADMSVDKEILEELKEKIELDCNLDIQDIKNNTCSIKRLLANKEIRENLNMESLLCELKDSEVCKEGYRNFREKCCKHYKQFNEDTVNIDGILRESRDKCQEVSRFLISGDCCQLIRMGFFVQMCSALKSTSNLSYPYEELLLKSFCKQDMGITRFFLDTVICMGKTKDAYIATLLKQWNSYITNHWYSYQLAREKYRNEKDVCEVIEQCCAASSDVMEGWDVPHTNTLDDIEETEEEKERKRNVTTRTQKKSSSGIWGKVGIAAVVITAGIIIGGFCWYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWI6</accession>
    <name>A0A4Q9LWI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0556p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000556">
        <property type="protein sequence ID" value="TBU13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0556p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="28811" checksum="9B0438A1E82D4BE0" modified="2019-07-31" version="1">MYKNVRDIDFMLRKLNIFPSLVRYLLILISIYILLAFTVTYRTHNYLLKNIEKFVQTEKGKYAMSVLSTNLLILLFKKEDKDINGTIRYPSEEATVTEECYTKIHNSLSRKGVPMYFIRDMDIFENECSNTLELKNFFKLTNSMFFKAFRLLGLSRVPKYLCVSKFLKLYNFICSNSVPKTNQEERNIVFYTGDEELKSLCFDLKFDLEGVAPINQKDFSISFSEFGDSKILIKKILAYMIFSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWP8</accession>
    <name>A0A4Q9LWP8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Man1/Src1p histone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0826p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000826">
        <property type="protein sequence ID" value="TBU12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWP8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0826p0010"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="466"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="783" mass="91170" checksum="6AA97573F035E95A" modified="2019-07-31" version="1">MRKHHTNPTKQEYLNKDFNYKNLTKNQIASILSECNCTVPNIPTTKKNEFFKIYKTEIFDRIEELKSKYLNVKPDGRDIERVDKVRGDSVKEDRDRRDSIKEDRYRRDSIRNIANTGDTGDSRNIANTRDTGDSRNITNTRDITNTRDITNTRDTRDTRDIQNTNTRDLYKSGNESVFTEDNPFQSETDVSKTPNRSKLGNNFVRLSVNKEKRHKKREENEESEESMSSSSKDYDSNSSRDSYKESKDYSSSPLIKKRGRRVKNVSPLSNKSGDKRVSLSKSPLKYKRESLGRLGDRGVNDKEYDYKGVSDRYVDNPLTSNKSRRSIDRGVSNSIDDYKGVSDRYVDNPLTSNKSRRSIDRGVNDKERDYKGVSNSIDNNTPLPTRRSTTPSNTINNPYVTTPLRTNKSLHSISQHSHPIFFRNPQVRKSKRNIFLFFLFLIFLTCYLYVKHFCKYCTDFEEKNFIKNFCVPKPKNLILFENEFVCKKGYIYKKKYFCRNLCVKDLSVVNKIRKSVDFIVGELQICNWKYIHGIVDSNKVSIEEIKNMCDMIFGVFEGESNNSRDNTKSSTRDNIKDNTKSNNNNTIKDNKDTNTKDTNTNNTKDNKDTNNTINGNIPFNDILVELEGRKGFLRENNNFYTFDVKVPIGLFIKFYILKIFKILIIPIFTIFLIYLIFKYEIKKRKKNKKNKEMADLLVKDILEALSLQVLHNSKDKSVISCVALTQLKDYFGIEDDVWVEVVGKIRRNSNVRENMSVVKGEEMRVWEWIGPIIGVHGKRMSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWY7</accession>
    <name>A0A4Q9LWY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0612p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000612">
        <property type="protein sequence ID" value="TBU12827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWY7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0612p0020"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ssl1-like" evidence="1">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="366" mass="41808" checksum="38F7A25CE6E6E4BD" modified="2019-07-31" version="1">MSPSNFFSWEQQYKRTWEDASPSVTSFKQIAKKYDNRPLKRLTIKHLHIIIDTSVNLDHPDFHPFRFSLISILKEFHKNFTFRNKVSKISFSNLQLEYYNEPTTNLLEVCEKLFDIQDIIQRSLIMIDASTKLLNEEPAGIAKINSSKIFKENYKEQTGDQQKILKVKNTCLKEFLIISGSLSTKSVSSDLFHFIKKNNLKIHFISLGGEVSIFKKVSQTTGGKYFVPLNIHDFANILMEYCIPEILTSNFVSMIPLGFPLFSENENSVCVCHSTICKGYSCVTCGAKVCTLPISCPICNTQLISSSSLIQNIYYSFPLKQFSVGEGLCKICGLDGKWMCNDCKNTYCDTCDSFIHENLKFCLFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX45</accession>
    <name>A0A4Q9LX45_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase</fullName>
            <ecNumber evidence="6">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0583p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="6"/>
    <dbReference type="EMBL" id="PITK01000583">
        <property type="protein sequence ID" value="TBU12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX45"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0583p0040"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="901" mass="106769" checksum="36EAA6EC36088AE2" modified="2019-07-31" version="1">MEEDEDNIVRFNKLFESSIMIPFRYLSFFSESAYVSILYEFISVKVIESTKVHFKIELSYLNYKWIISRSLVKIYELEKLEHLKNKIYRIQDNLVDFKTDKNKCIENVLKSILLASKYIDQREILIFFNLSKLSFIGRKNFEGFFSLREQYFSPKVVCCFKKSKHYSKQSTCYVVCKEGYLVFIKNFEDQKIDKIILYDKYFKVEKSTSLMSYSLKISNSEKCFVLSTKNKEEYNEFYDLLNKILMESCNTATHRFNSFSPVRKNCDFIYYIDGKYYFEELYNQIKKSKNQIFMAGWWISPDIYLKRKLFEGKLDKKYRIDTILKERAKNGVKIYILLYNEYQYALPINSEYTEKKLGGLHKNISIIRHPKINFFDINYWSHHEKIVIVDQEIGFLGGIDICLGRFDTYKHEIFEDKKASKQPLKEISFRKHANSNQIKNLENILEKPEKDYEIYFGKDKQALSKKDEDYSSKWPGLDYSNPLKMDFRSVGQIKKSLIDKTKIPRMPWHDIHSKIEGDIVYDLSRHFIERWNKARETEKNPENFDILLLNDFKPSESNKSNSIEVQILRSAGFWSLNIPTEHSIQNAYLELIKRSENYLYFENQFFITNCSENILEYPVNQIGNAIVNKIQQAFKEKRQYKVYIVIPSLPAFEANFTSKKDSSIKQVMHLQYKSISNGENSMYHVLKRKGINPEDYILFLSLRKGYIDDIKAAYEQIYVHSKIVIADGKLGIIGSANLNDRSMLGNRDSEIAMIVEDEGNGKIKNMMKDLLIEHLGLYSDSALQDNNDTFFKTFFDKNLLDLGNIDFFNTLKSRATINTKIFREIFRSIPDNDVKTARDYRNFIKMASLNTIGIKDRHVLFKAFKRIRGHFILFSDKFLEEEEEIFKIFDLQQFLPSKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX91</accession>
    <name>A0A4Q9LX91_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0791p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000791">
        <property type="protein sequence ID" value="TBU12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0791p0030"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20766" checksum="F5609A4CB771BA13" modified="2019-07-31" version="1">MNYTSALIYMFEEDRRDIAMEVNIKKNSIIRGYFISMVETYGSFSAYIEIKNEFLLNNSYMKFNDEIHFSFSSKDKPSDFIPRIEFTYETSEDTFDKINAKNVSIDPAIKTLSKLRNQLHDVAKETKTVKKCLNEYSINFENFVVVSIYISLLAFLCSSFVYAIRIKNFFKRKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG5</accession>
    <name>A0A4Q9LXG5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0195p0020</name>
        <name evidence="4" type="ORF">CWI38_0419p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000195">
        <property type="protein sequence ID" value="TBU04021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000419">
        <property type="protein sequence ID" value="TBU13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0195p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0419p0010"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="63"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="246" mass="29055" checksum="AD00E620B07F4558" modified="2019-07-31" version="1">MARLREKRDYLLRKENEEYENKKNLISKCLNDNKKIPYELRDTAKDVLEEIIFTSPIETMECISLFVTTSRDPSSSLMRFAKHISLTFPTATLLKRGNMNIEELDRIGKENNCAIMVLTENKGIPSGMIVCYFSLGVIYKYSIHNFLLKDVKNIGKNVFLICEGEDKIWEKAKETWKILFPQCNKSNRFLCLFWKDNMLMFREYFTNKVIEDGCKFNAKLYEIRKGTFNCEGEKEWVYKPYMNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXG8</accession>
    <name>A0A4Q9LXG8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0758p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000758">
        <property type="protein sequence ID" value="TBU12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0758p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22785" checksum="89B37FDB87675C74" modified="2019-07-31" version="1">MIILPTDINNQEKPDSSFKIFYLFIEMHRLNEPTNNINEESDLEEETIVVKEKGGGDRRSKLTLEIKESLQTYVDLELNINVDVASSTIDRAHREFYYTPKRVTLVPEQNNYATSFRKLEVDNDDKNFVFLDEVGVAIVRRLTRGRNMRCESAYLYEIALYRIKYLPPYSPFLNRIENVPSDWKKSNSRWCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI9</accession>
    <name>A0A4Q9LXI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0549p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000549">
        <property type="protein sequence ID" value="TBU13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0549p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="346" mass="41050" checksum="0ACA2A431D657F8C" modified="2019-07-31" version="1">MRYNSQHFLLDEETLYADSDTKKKLLPKSRIEKAWDELSDYYAKRLEDTNRDIIESTKLSNKISQARLEMETYRSVDDLISQNILKEYICAEKPVKNLQGSIKPKICKMCISIADKYLKIFDEAVECENKINNILSKYNRYCSDQDNYTQKSYKIILSDGFIKIFVTQQIYILLNKNCEFIYPEKWLPTGLSCIIQYDGFVFKGSLKPQIFNDAVENVREYCEEREIILERKRGKLKIIIYRGFDTQESELCTFVLKSLKRKTNLDKIMDLSLLYLSKLFTFSLYRYIDVLNYEFINFTGPVLDDGHTEMFFCVSSSNKLRILRDLKKGNFEIYWNERKMIPKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU1</accession>
    <name>A0A4Q9LXU1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0375p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000375">
        <property type="protein sequence ID" value="TBU13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0375p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21982" checksum="AF7D54181EE61B20" modified="2019-07-31" version="1" fragment="single">RIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYRCSVEIIPYVMTWDGIETKYHKSHLKRLEIPMNVEAYIQAIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREENGGTTLEEPTRNINEESDLEEETVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB4</accession>
    <name>A0A4Q9LYB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0452p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000452">
        <property type="protein sequence ID" value="TBU13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0452p0030"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020659783" evidence="5">
        <location>
            <begin position="24"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="56"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="7">
        <location>
            <begin position="254"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="7">
        <location>
            <begin position="435"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="628" mass="69750" checksum="112555A70F617071" modified="2019-07-31" version="1" fragment="single">MVNNNIILLLLIVIILFLTLNNTNNNTTNNSNTTPSTNNLTYNNILHLPLKVGKETESVFSDTFLTNTSLVVNALDNIEARLYENKRCITNKIPIFESGTLGTKGNVQVVIPYKTESYSSSRDPPDKSIPLCTIRNLLHCIEHTIDNFEEKIISISEYIKGDNYRDSKLEGDNDSTSNYRGVDYGIDLEQDPVNDSTNKQDPVNNITDKQHPLNNSTSKQHPLNNSTNKQHPVNTIPTNNTPHTTIPTHDNLSTESVAIGEDIRVLVSSIPKNIYECVREGVILFNKYFYINIKTLIETFPVGHVTGEGQPFWVQPKRPPVPFIFNKFDCLHVLFVQSYCRVIRSVYGIKGLEGEGEGEGEGVSYKEVEDIIREGMYDNGILEGGNGKGGKIKGVNGKGGNIKGVNDKGILEGVNDESILEGVNDKVSNINGVSNSSNKQYPFNNSPNKQHPLNNCPNKQHPSNHQANTVAPNTPFNNNTNNIITLHPVTLEKDNDSNGHIDFIYACANLRARNYKIKEVSKLTVKGIAGRIIPAIATTTSVISGLCVLEMIRYVLYGNGYKNWYVNLGLSFIGCTDVIEAEKMECGMVRDRLEGVNDRDKLEGVKDRDRLEGVKDSTNTLHPVNTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB9</accession>
    <name>A0A4Q9LYB9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0657p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000657">
        <property type="protein sequence ID" value="TBU12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0657p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="82841" checksum="F598E4F98C2DCC7A" modified="2019-07-31" version="1">MFIFYHIVLTHRFIYLLKKEGNSNLYFYSKISEEKLVFEKNENHLYLRILNDKNTGSINNGKHVLTYKKNNFIRFDILDDILHQNISDNIIWKIECNFDFLYILKLTNDISELSDGITDVEFKWLLFSFQYLKVIENKNLSKFIRALYFNMLLNQNINNSKNENQNLKVVFSLYHSLEIYSVFKRKLIIEFLNALMIRHVFYDENLILCRNIKDTFDPSLLNEHIPYKSLLINDFKVFSILEKIITNRHIFNYFMFLLEQINIKAFILNCYQVSQTKSQNFDFFSNCKHLFKAITISNLTIATQYIFSQLNESIDGNLEIFTLRNSIVDGRYVDTFLKKHNLKGLKLDNVNMGADVSFLDAYMDSNQSLEYIDLRKVKFNFSWLINLTSSSNIQKCILFFDLSFSEQYFIRECAKLKDLHIDVLLYLQIRFYSYRISEEFCIFLKNFRSLQTLILLNYRSDKNTDLLLLNAIGTLKFLENLTVGNNFFSTKFYNYLFQIPRIETLIINNFFLHKKTLELKPFSDYKYLTRLNLNSVKISGLSLIEIFKCENLKVLSLEFCELKSIRNIKLLDFRSLSIKSLCLSGSNLKAFKNLDILASLEYLETLFVSGCKSYLCNLTKLSIGCNLRLKKLTYKWGNISYNDLNRIKYLEVLEKLDLTECKFTEGMKLYKLGNDCRFLHSLKHLNLWGVRIDLMIIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYD4</accession>
    <name>A0A4Q9LYD4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0445p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000445">
        <property type="protein sequence ID" value="TBU13396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0445p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="69503" checksum="1C87423E5C5DA4D4" modified="2019-07-31" version="1">MTIEKFYTIMHFLEYFRVKHDNKLRNVIKIIWYSLVKSEEINNFDIEKVSFHFSKQDYFSHKMFKKISRKYFKVIKFEMNTINSFFSKKEINYISNKGKCLYTIEGKHVLTIINYEFDLFFSKKVDMHPKSKSLFLIFLNTLDIRYLPFCDICIINEIVFVRTYISDKTIISLNVNLNFVDLEKIIFINCNIDEGMVVFDFLSKINESVFYEYNILSKKYSLHEIKVIKNLDIVENIVEILKRTYHKSTPEELISHNNNILDKNKDFYLILLNDEKSKANVKIFEFFVYVSSSLSLRYFYEYNGCFNNISITLKRLNSKQLFKSKDTIIDKNTKCIKIASSTITSIFLNDILSVIGLETLGINYSDILFEKIFVLRTNLSNILISGLKHARSSLTWIESLKLSRSLSQFFYITELGVSELLFENYDLSSIKKGTLSQFSIDKSNLKAFSNLHNLKELYFHRINFENISLSELFCASREYNIKRIKLEKIYIADEDLIFITNLKNLKELEFEGCYIQQKTYLHCIKMLFINEFYIELICSHLSEEIIQFIKEAFKASGYQKIYICSFVEISINLDLLKFAIESSLKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYF1</accession>
    <name>A0A4Q9LYF1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0313p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000313">
        <property type="protein sequence ID" value="TBU15319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYF1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYF1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0313p0020"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU15319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="352" mass="40002" checksum="6FE5B483E733A3FB" modified="2019-07-31" version="1">MIKRPVIDKSKFYDFKHVNSCFVTNSEIISGSICNNTNIISLGSSNGDLKLFTLKNDKIENFCDLQFMDSPIFCVEWVNKENIALGLGTGQVLIYNVVTDTNSLIFCHEGSIRSIKNNFSREMIFTGSTDGSIKGWDLRTNKCEISLISQTESSPKPKRKNNIIYQDRRINSDDTGCINQRSTITAMEFINDYNLCSSQTPGSKICIWDLRYTKKGFFTHLSYEISRKAVYGILSYNNKIYCASSDGRILILRNDGTVSRILGDPNINSSYGNIIYDRYNDMILAGLKNRVFLINENNYQNIGFKMLELGNINGVISSNNNLITYGTSNNIEIYESIFDNKYNLFDLIIYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYK7</accession>
    <name>A0A4Q9LYK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0619p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000619">
        <property type="protein sequence ID" value="TBU12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LYK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0619p0010"/>
    <dbReference type="OrthoDB" id="6093641at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1293" mass="145789" checksum="01F7C28293E6CE14" modified="2019-07-31" version="1">MKVKPLSKIGYTSIPTFISSTQETLLISFTNNKVVLIKEIYKDSKDKDMDSKDMDMDSKDKGIDNNTNTNNNTTNTNTNNNTNNPPYNTPYNTPYNPPYNPHYNNTNNNTNTIITYITLHFTPNYTINTPLIYNGYIITYSYKYLYVIPLTTINNNYITYNTKSSYCYNYYSIISSITCYKGNIIISQDNRIKVIRMCNRLGGDKGYGGSNKGDNKDSVSNRDRVSNRDNTNKDKDKDKDKDGVSNKNTNKNTNKDKDNDKDSVSNRDTTKDNDKDKNGNSVSLYTKMSYYFTSNKDNNTTINTNINNTIKSKHYTTFTDSTVISLTSNSYYIIALTVNTINIYTYNNTLLLHSKLNNNNYSSLTPLNTNYILIGDNKGSVIVYSIKDKSNSKYCISKTPISKIGVYNTSSNKVCDGSMDGDSSKGDSNKGDNKTSNKGDNKTSSKDDNKTSNKGDNKTSNKGDNKTSNKGDNKTSSKSGDNKTSSKGDNKTSSKGNNKTSKSSSKTSSKSKYINTILLHSNGMLYILSNTYKVLKTLYCDTFFLTDKGVYIIKDILNVLLLERSYIESNRDMCEDVKTYITNKDNTSNNTYITNKDNIVVTITSTNTPITNTYNTLYILRKYDKVFFINNKYICYNNNKITIIINNRIIKEIKVKHHIYDILFIKGVSNIKGVSNIDGTNIKGDSNIGVTNINDSNIKGISNIKGVSNINDSNIKGDSNIGVSNINDSNIKGDSNIGVSNINDSNIKGDSNIDGTNIKGDSNIGVTNINDSNIDDSNITPCYLMVILTSKEIIYTDYNTLINKGIVNYNDRGVISTTNPTNTNNKPNPTNNDTTTNPTNTTNPTNTTNPTNTNNTNNTNNNTGNYIFYINNMSIVNYDSNSVILKDNEYLYKYDINKRVLVKVLEIKNNKYIKKVLVYEDNVLFLYDSYLEDKGFRVYDVLDCYIGGCYLYVIKKNELSIYTMKYHRNDNEKGGNVSGEGVSGTSDTNTSFGKEVGDNTPLNKDMEDNTLLGNTEDKRLLNNDIQDNTPLNKDMEDNTLLGNTEDNTPLINNIEGNTPLNNTTDDNTPLNNTTEDNTPLNNINNTNTLLDKNLTNNTPNSLIYTLICSIEINILKTVCYNTIIYFITLNNTIKVDNSIYHMNVKCSDIYFYEYEGVIYVGIKNDCQFSFYREEDINKCFKKGLGNEDIGDNNIEDHICDGKGDNNIEDHICDGKGDNNIDDKICDDIGDTVVIDEENKIDSFFSVNEMEFKERNEDLMDLCENVERLESTANRYGKEASDLKERMKKKFWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX0</accession>
    <name>A0A4Q9LYX0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0580p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000580">
        <property type="protein sequence ID" value="TBU12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0580p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="14833" checksum="1190016FAFF1226A" modified="2019-07-31" version="1">MFHRPKTDNNFVAKPTEYDSNLDEKHREINRKSIYSTIPVIITTVICNRSSESNRFINDAGAISINSEVLCSNISNDTLCVSSKDKKNDKKCNLNFGSFKKLIARSSKYLKCKNHEEISDSEEEQLIKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYX4</accession>
    <name>A0A4Q9LYX4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0262p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000262">
        <property type="protein sequence ID" value="TBU17942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0262p0030"/>
    <dbReference type="OrthoDB" id="2195638at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="21419" checksum="0ADE156851B02C11" modified="2019-07-31" version="1">MNTSLLKNGELFTSQYERELLNKIEQITRSEESSHISNIKTMKNSLIDLKRSNSFIETEIENLKLQKMKEENSYMKLNQEISSLSKELFMSEEKNENLELELIELTNEIKNKTAYYKSIQYPTSNSLFIEIFRKFHIEWKNDKNIICTIKNKKLNDVFTIFHDDNKTEKEINDLLWKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ04</accession>
    <name>A0A4Q9LZ04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0554p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000554">
        <property type="protein sequence ID" value="TBU13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0554p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020566174" evidence="1">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="504" mass="59882" checksum="8F17BD9B2FEC3B17" modified="2019-07-31" version="1">MNNLKIIFSAVLFIFFQLGDCEQEYKKGEKISNMIPSLVYNIDSRIFISIKPRSKVENTILTNIFFKFRKECLDYVLNKIKIEEVRYLVRKEIQSNNVDPKSYNLEFQLYIFVRNIQRIALDLFFNFYSKHNTILENDEIKIIRENTEAYLNKNYILCTIDQIYNSLRNENISKIYSRSKNISFKRLFCYNTNQDQLITEILIDHSKLIIENIISCAFVRISLGYEDLFEMLKALKLTDIPHFKYFKPYKKNENYAINLSNKNGYISIIKKRGLDVCGGFSTQNADVFPFFKVERKRKHEGRKSINPLFQNDRESFLNPINQSSVFYEENNVLRIEKLEFAYDTLKSVLTNLNKFKESKPNLGKTLIIIDLDLRHFLTDILLNYFIMDGNILNIVLNNEAMEKPHEKTCENIQIYLLKECNKHIPKLPPNKRTKYIENHYVIQIRPLKLSAKKIRKIVSGFIGLRKIESRLRCFIDSNKRCFYTLIYKLINYMNKTIEQHLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ65</accession>
    <name>A0A4Q9LZ65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0359p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000359">
        <property type="protein sequence ID" value="TBU13696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0359p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="22360" checksum="0E5322E1E6369D2F" modified="2019-07-31" version="1">MNFSNVIFIYLNFTAEQYIHASKNMTNGSLSSNEDNVQSENEEQNADSLEKNGIDLGNFVSMENVGRNMSSNNINIKLRAENRTKKRYAYNNLNEKEIKIIKSNFCAACDEIQKYVRNMLINKKQYILEEEDFKYFSDKENQILIFKINKIRSKAFVSTKCIYAIWRSKVSDILNKASLVLYSILPEIISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP3</accession>
    <name>A0A4Q9LZP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endochitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0210p0070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0070"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF79">
        <property type="entry name" value="CHITINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020228996" evidence="4">
        <location>
            <begin position="16"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 19 catalytic" evidence="5">
        <location>
            <begin position="497"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU19489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="653" mass="71976" checksum="4219856D769746D1" modified="2019-07-31" version="1">MFFGILLGYLGISIQRDICLPGSSECKDNSMHVCDVEGNWIIVDCPENTRCELRNGGLTCVKERNIERKINQETEHNDIEKIFDVLDNENKDMEAIEKGRYFDNANNGFGNLNKDILNKDEKVTMSKCDGCFLDKREVIPSITTIFSTLIMKPEKENINLRTITETFIQKIINSQNKPQTENFTEKTSKDAKTQTKEITTTVTVTNKMAPSEIKVEIVTAKKNIQKNNQIIPIPINITKTSGIPTGSSSNVSSSNISSQSMSSTSNSPSPQSISSAQTSNGEVIPGTVSLQCIKPLIPMNLPTMISSPATSNFIESNDKEVKETNFRNINFENLSNDINMKKDHNIVNKSNVIFDTEFMKKEIEANATKNNSEKNNSNLFDSSNKNGNVKFNENNFNDHEIHAKNKSNLGESVSKNINSDLKNYFLRNESYEKSQKLLSKQDEGSSGGSSGGSSSSGGDISAQEIMESASACGFSPPQENCDAVAEAMKKESFKRDEGAMFVAQIIHESVGLTKTEEEACQGGTSCASQYDDGTGQPDKSYHGRGFMQLSWAANYKAASEGIGMGEELVMKPEMVAEDVKIGAQTSVWFWVQNVRNAPGVSDNQFGATTKAINGALECTGSNDDKSKKRYEYYLKVAEVLKIENKASEEGCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M023</accession>
    <name>A0A4Q9M023_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0400p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000400">
        <property type="protein sequence ID" value="TBU13541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M023"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0400p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="755" mass="89172" checksum="190D91CB0F6BB0B8" modified="2019-07-31" version="1">MIQKKIFSEIIIFVNLLEVEKPACNDFISYVSNEESNRYGCASDFNKRKRKSVFLKGLCKETRKIVRKRISVHHLNPLNLKTNEFGTEVKQEIQIYLPHITASDFDLFCKMLQFYCDPLDYLPLETFFKFLNILSCLNLVLDKNLDKILLNLLISVRFPLENDIYELKPTILQYIETYTISSDIVTTMGKLFKNLSLFKIGFELILFLNTTNEKMYHYYNVKFETKSAILISKNLKKIFSNQNFKNTLIFKVIFIVFLKMNFKTAIFHTIPSKNTELRHFLSQILDSVDKVIFYKLSIDKKPISFLNKENCFNNLTTVYFFLPELQSNILSFINYLLNISEIFIEFDECFEESEYKKTNMNYQVVIKVVRYRLNRLVILENFEFLDIKNYILNSVFEIKSINDFEEQFRFLNKIVELNNVRVFLYGIIPLATINIIETYIWCTSINLILDFKNEIYSLQIIPFANVKTLKIRNTVINTGFIGCILNIPALENLYLFDCSITEYNETVSYPKNDSITSLNLYGKEMIGIGFIYKFLSSMINLENLALFNDNLSVLLDSDQKCKFSPKIQLKVLEFCCIFKNSKCDCFFYFPFFVNQEISFEQGFPPGTLKKIFSIPENTNIKKLSYLDNYLDYSDIGALENLKLLENIEWTGNNSKIRFYMLFNITKTYNIKFLDLNEVEFVRKDIKFICSLKSLEILNLTMCSFKKKCYRMIRRNKLKTLKCFYFENFFSTKNKKIKMHLQEEFPSSILSISLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M039</accession>
    <name>A0A4Q9M039_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0174p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M039"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M039"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0040"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="242" mass="27184" checksum="0F88016BBCEBE129" modified="2019-07-31" version="1">MASGKGGKKDPITSSKREASDPRSVCKLNQLHRIIRTRTRMRVSQSACVAVAAGLVYLMGEILEGSKAAAEEEGKKKILPKHINLAICKDEELGHVGHDWLIKGGGVKSAVSHDLQSSKRGKQTVFCYIKDRNVIRGVEREYQQCNMSGKTLKHFAIDSINENNLSPQEISTDNFQFSAKIIPKIISWDGIRLQIPINVEVYIYSIALKKTLKLNNEESWERASIGVIKRAKIHEEPTYHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M060</accession>
    <name>A0A4Q9M060_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myb-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0387p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000387">
        <property type="protein sequence ID" value="TBU13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M060"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0387p0020"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="246"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="249"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="350"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="403" mass="48124" checksum="D6A5ECD8F0C51673" modified="2019-07-31" version="1">MENHNYNKNGKYILSDGIESKKESLEIRKIQNSTFIKNTSSIKDSLYFYENAIQENKNKQRNLFMIINQIDYYLRRIKHHTTYIFSTPKSSANSLILLTTNVKDTSKSNKGYLIRSLMYKYREVFKEEDKINPESSFWINISKLSGESKYSCYNKWLNDLSNLSLKYKNRIVLAKNNKKNENESSNNFYTEEKTDSILSLSHLKQSKENIGKIVYNNFKNGKSWMFISFQLEIHPFNLFKNYISYLNKDKRCTWTEEENKKLIAATKKYGHGNWILIAKEVGTKNPRQCLHRYNRKYQPKINKGRWSEKEDNLLLKGVEMYGTRRWNKISQIVATRSESQCRERYVNVLDPNISHERWTQKENDYLLYLISIHGDKKWSFISSIMGNRTDNQCRRQYFKLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M076</accession>
    <name>A0A4Q9M076_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0382p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000382">
        <property type="protein sequence ID" value="TBU13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M076"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0382p0010"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="65" mass="7378" checksum="EDE593F096B380B6" modified="2019-07-31" version="1">MHEEPTPPLKEDKREEDGAKNFKPKNNTPLISQGGTTLEEPTNNINKESDLEEETKVVKVVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M080</accession>
    <name>A0A4Q9M080_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0162p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M080"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0040"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="184"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="301" mass="35451" checksum="7DEEE10A2557BAE7" modified="2019-07-31" version="1">MVEVVRDMSSGLEGVNNISTTDRVNDLKYLCSKEGVKDYYNIYKNFNNLLDILEYFKCKITLELLAEHCEFIKPRYFSLINNKSGNIELLIGIMSHSVSNSVRYGQVSAFIKEKYNEKYMNIDINKDENKDRDREESEYSNSKYGCCNDINYNDSNTKPILDNIDFVYRMNRLLRLQETKKHLLISTGTGIAPFISFYKNRRKDYLMWLIYGCRNVCDDLSKDMFDRKNVVYSADYEYTGNYKYVSDYILGNVEGIKEFILSDCSVYVCGSIQMQKSVLGIFKEYFSFIIEEKRMFFDSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0D7</accession>
    <name>A0A4Q9M0D7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0134p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0D7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0D7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0050"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="53332" checksum="18F8B05849A081F7" modified="2019-07-31" version="1">MPSIKGPRSALTDFIEESGIDIKQLKKRTEQKETNEINEIDKSEKEEMSGNNKIIEEKICKKVVVKRKKIIKIEQPYEILNLENTKNRIFELPSVEFIDDLILEKYSFYLSKNKLMDLKMFKFLVENSKESLVVYDCSNILDKDFLLICKNYSRLELHYCGQLTEKTLNDILMKMKKLDILKITGAFLLHAFKIPKTIKSLDLSNCSRIKDSIFKKINKLQKLEELRLSYCYSLTEKCRLTVSVKRLFICQTKISQIFFSSTSILQNLEVLSVKKCPNFFSVKILEKDEERESKDDKSISFVNKWEYFIEYLKNIQVLDLDGISTIKFLVPLPFLISLNISNCFCIQNIIESILKNKNIEEIDLSRLEIEEFELKQLILLKKLRKINLSWIRSVNDDILTYLINNLSNITHIYVFGCFKLSPKLGELSWEIKEKVKIIGNPSETAFLLNSYTNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I0</accession>
    <name>A0A4Q9M0I0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1009p0020</name>
        <name evidence="9" type="ORF">CWI38_0135p0040</name>
        <name evidence="8" type="ORF">CWI38_0241p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001009">
        <property type="protein sequence ID" value="TBU00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000241">
        <property type="protein sequence ID" value="TBU18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000135">
        <property type="protein sequence ID" value="TBU20085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0I0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1009p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0135p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0241p0020"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="181" mass="21083" checksum="26805163D93C0CC5" modified="2019-07-31" version="1">MEYPLSTPWTVYYDYQDRKTVTSSNWEDSLRNVCTVENVPSFLYALENIETAERWPMNSNIHFFRKNIRPMWEDSSNINGGKWVLELSRDDEYDIADIWNKTMAFCVSESAYGICGCVFSPRRAFNRIALWTSTTDESVLEIGNAWKETVTIPSESVIAFKTHENALKGYWDKKAGDLYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R3</accession>
    <name>A0A4Q9M0R3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0108p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000108">
        <property type="protein sequence ID" value="TBU20230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0R3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0108p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SULU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="471" mass="55318" checksum="3C41EFFCA9191EEE" modified="2019-07-31" version="1" fragment="single">MGRSFAYCFVHVFIFYYVKNLSCSDTNYTNNLLESIVSSNLGQKNTYQFVQKIGEGSHGEVFMYKCAYTYQKVAIKVQIKTCRLDSQEIPVLKIMNHPNIVKYIDSLVIGEYECIIMEYVPYTLIKYLNKNEFNFMNLKIILKQILDAMKYLEYIQVIHIDIKPNNILLDENLNVKLIDFGICCTIQDKSLNFSMDSDLDTALKEFPQIAPEILSDDFFDNSADIYSFGYVCSFIQERFIKNFDFAEKNVRNSNVLFSNLIDISFKKSPVERSSIRALIFHPFFDELYEFLECFCNFDNIKLSAEAMKIEINDGKIYIKKENIEYTLYCLCHVKSKTLYSIFKSKNAEALDVSTNPDYKTDDSNTNKFAVKKESNILPIQFLNKEELLMIKSVFELIKKNAKKLQINSNPLDENRIDSYEDQIKKREHEIESSKDKLLAHENQTAQDLNRNESNNIYFWRLRRILRRVLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0R4</accession>
    <name>A0A4Q9M0R4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0119p0080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0R4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0R4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0080"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="153"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="406" mass="46893" checksum="4921F847D0D90E6D" modified="2019-07-31" version="1">MHVKDKSKSKNLHMLISGRPKRNRKGEIIKEAEFQKTTRNNQSKIPPDTKWFKATRVVTKQELQVYENCVQKLNPYNVLLEKGKIPFSLLNERITKKKYNVDSNFNVKNSTFCNKSIEELKKLLQKNEKNEEKTEQKIDDESKAGKGNSKRIFNELYKVVDSSDILIHVLDARDPMGTMCDSFMETLKQHFSSKQVIFLLNKTDLIPTSVTASWLRKLSVNNPTVAYSSFSIEKSFGKESLISLLRQYSKLYKNKKQISVGFIGYPNVGKSSIINSLRNKLVCKVAPVPGETKVWQYVRIMRRIYLIDCPGIVPRGDDSVLKGGVRIEMIEEPEEYLNEIISKGREGIENKYKVTFQNSDDLIDKLCVKYGKLSKGGVYNRKEVAKMILYDWTRGRISYFNKPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S8</accession>
    <name>A0A4Q9M0S8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0107p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000107">
        <property type="protein sequence ID" value="TBU20240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0107p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="164" mass="18392" checksum="8F09DEE25FF32C43" modified="2019-07-31" version="1">MIIDNVIPVIKSKFPQAYKKKTIYVQQNNAKPHFSDNDADIVALGSADDRNIKFKVQLANSPNLNVLGLGFFNSIQSLQHQASLHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNCYKIPLLSNGKLRREGRLLEKYVCSKEAYLKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V1</accession>
    <name>A0A4Q9M0V1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0111p0070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0V1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0070"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020906770" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="33675" checksum="E05EF6A5E369EEC3" modified="2019-07-31" version="1">MKNYILIFFLALYFLFKNIKNILPCTFIDQPGNFLLLTAHPDDESMFFAPTILNLKGNLTIMCFSTGNYLQETESEMNMTKKEISEDKNNYFANYFMKIEKRNYEVKRNKIRLKELKNVCKFLNRNNKFIQNKEIINRNYLNTKCIILNLQDNSDWDTNEIVSIIRFYNLIYNFNCIFTFDRNGVSNHKNHISLFFATRKFRQEIPVKCYYLNSKNIWYKYFIDFSLNKNSFCSGIIQYCTSIRMMLFHKSQLLWFRILYIFFSNFMIYNDYTDLDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M162</accession>
    <name>A0A4Q9M162_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0071p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000071">
        <property type="protein sequence ID" value="TBU20434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M162"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M162"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0071p0030"/>
    <dbReference type="OrthoDB" id="10068428at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="873" mass="103110" checksum="A30F6D4DA4E7A192" modified="2019-07-31" version="1">MKISPYPEKVLLNKYYFLRTRSELLLRIIYIVEEISPVKYVGILIDKEDKFKNKKILVDKKCLLIFHPKTRLFQHLMSIPEFRSDVGIRRTLCVLGFPVDKIMIKMENKNFDTSDCEISASEFENEYSKYLKYDESGPFLSGNTFITDPLKLVVPGVNSLNVYRLYVIVCKNGGMERITNDQKWKPLFYSEMKKTNVSYTVRTFYKKYLYEFEYLRRIKIRYDLYKNRIDSCKSNPTEDKESSKNNEIINEEVNFENNNLNEKLNKVCEVSEQDINEKLKDKNNENTNLRIKDKNNEIKNLRITDRTDENKNIRIKDKNNEIKNLRITDRTDENKNIRIKDKNNENKNIKINGQISNEKFKNKNLVSDAIITRISIEDNIFNYKYKPYQVVMLITENGERYYGVIKLRRNKGLNMYYVQFVGWNKEYNEWYCEDVLEGVIIGNGGCKLSVEDIFIAMGNKKPSRSSKANYLIDDPLIREKHCHNVSKVGDRKDSEGSDSDRGGGRVLNMYGEKGFRDRRYDPNMEVNTENIKGVKYRGVSNKGVLDRGEWYGDYNRVLDREEGYCVNKGVLNNREEWYGDYNRVLDREEGYCVNKGVLNNREEWYGDYNRVLDREEGYPNYNRVLDREEEYSNYNRVLDMEEGYSNHNRVLDREEGYGDYNRVLDTRKCLGNFKGVLNHNEGYSNYNGVLDREEYYGGNKGVLNTEEKFVDYKGVLHDRSPYYNIKGGLNRNDNVSSTLNYINTHEQEIKDLNWKDISNNEKYGFQNTNIYSKLNNMNITNLRKDHPSGMNISKEKKISSDKSNSESSCLLIGNKRNKSRLSEEKPMPTINYVKKYFRWFKGDWDTEEMRNFMACVGLNGVNDLNENNYMFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M178</accession>
    <name>A0A4Q9M178_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0285p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000285">
        <property type="protein sequence ID" value="TBU17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M178"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0285p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="108" mass="12962" checksum="DFAD1577A2B670EE" modified="2019-07-31" version="1">MKEQTRLFILYKRKKSKHSSKKLYPLANELGLIYKFSIEIIFYVMTWYDIATKHHNSYRKRKSIPKKVVYIQLIVLKKTAETIFFDRRTGLNRDSRENDSSSNQAINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X1</accession>
    <name>A0A4Q9M1X1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0257p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000257">
        <property type="protein sequence ID" value="TBU18005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1X1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0257p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020752364" evidence="7">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU18005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="49431" checksum="754BAE031CD48DE4" modified="2019-07-31" version="1">MKFICKLLIYKILVCEIDCSNINFTESITFIKNGVSEAFLPIKHLGFGVQGNVYLVQKNGTDELYALKVQVKRNRRVLITLNLFKNYLKHENIVKFYNFKEDSTNDYLLFEYLPITLEKYLASKKKTFLNFTFIMKQILDAFNFLKTRNIVLGDFKFDNVMLENNLKVKLIDFGIAHFENYQYIWFTDNDIRTGKNNRGRFSYIAPEIRNGRVYKSNSDIYSFAFVFRKFLTKSESNFINNNDGINDLLNICLEDDPNVRISADVAPFHPLFNVLYSFVFCFANLENFGISNEETKIKIMNKVLFYEHPEYSFALQCCCSEDKKEFTKFKYSIDQINMQCTNYSMKIANERTKELAEFRAIIGDAVLPIQHLTFGYYNELKNIFNVIKPENYKTKQTQKKRQNPDTKTPKEPQKRRLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M237</accession>
    <name>A0A4Q9M237_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoplasmin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0241p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000241">
        <property type="protein sequence ID" value="TBU18428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M237"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0241p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11336" checksum="37F713C794E627A8" modified="2019-07-31" version="1">MPYKSLLLREFHTYQQPSTRKTLTFYNAALTPNLYDEKEKTSLYFVLNDVPTILCTFIPFKYENQPLFFQIDLNSKISFYTLGPNDIDLLYFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I8</accession>
    <name>A0A4Q9M2I8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0205p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000205">
        <property type="protein sequence ID" value="TBU19524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0205p0060"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="15104" checksum="95128FC158899AB0" modified="2019-07-31" version="1" fragment="single">DGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPMIDMNDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N5</accession>
    <name>A0A4Q9M2N5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0005p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="940" mass="105023" checksum="E10EB53EF7E77D73" modified="2019-07-31" version="1">MQKKEYIVWFFSVIFLLFNCCFIYCGVINEQLNTDTSFLRSPELDLATLPRQHGFSSSTPARHVLKTPEYSYTDTHEAAVKCPTKSGKANSALFEKVLRKNHEQKHKNENPILDESVNNSDDDSNEFYDSLNFSFSESEAHKTESMFDTTSVLSDITEENTSDFSRVEDASKDGCNSIMNEGSLNASKADKSKVIFERFEEPLSEASASLSSYSPNTSYSRSRNSSFSEIETSKNAGDANNLRGNQEKNISYKISDSVLKQKINRALGNNEISVPNRKEDVDEEDDIGIETDLSEECPLPTTNNRIRKNEYKCRNPNDKENISHCTNTSGSERVSFSNSETSLISSVDTNAASKKDSGFSKHEPLDPNTGSNGAAESEERITGENSSKDIKIDINHNSEEFNHNALRKNKVLSRNDASDGDVFTRDDSASFEGLEYKNCLSKTDSNGRYSITQETDSYKNHAIAVHSPMPLPNFSLHSRGSKCNKHKFFDSMGVVSYSESLLEENLEEPSIDECSNNNILGNSLNSDEFNNGHDMISKPEMNISLDSMIASDNFPSVGASASYRSSDEECSASNHGNKTDAYQGNLNGLPVQELSVQNRPDSKQKLKNSNLPDIIILPIEENNYETSDSACFLEKERQNVCDFNQNNSFQYSSGTLERSNQVLKREELNSALSKEFPTRENNIDEAISGINTNNFSLGLTDTSIPVDIGSSHGFLMPVPSVISTSLPMGDNSLIIDENRVEGRIHTSDFFTHENYINDPEEEDTNGVNQNSTNNLFSPIEFIDDSVPNTVQSQGYISNDEESLNVLPNDADSENMIVQLPDNISSRIIDGSSNPSVNDFLTHTSQHQDEVQSEINADLREIAIPKISEIDVPSPKEEPPNKPNESPKGDLYLLVYFICYTNQNIRNSKKLKKFENKKSPVIIFAANLYLMYKIYFSKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2P3</accession>
    <name>A0A4Q9M2P3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0005p0150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2P3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2P3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0150"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="140" mass="15927" checksum="0F81C4273D641A54" modified="2019-07-31" version="1">MERTFIMIKPDGVKRKMIGEIFKRFEQKGYKLESIKSLVPGVEIIRRHYKEHINKPFYKSLEEFMTSGMVIPMVWSGINIISGARKISGATNPNDADIGTIRGDYATEVDNNLVHTSDSPKSAEEEINTWFDVSELKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M383</accession>
    <name>A0A4Q9M383_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0039p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000039">
        <property type="protein sequence ID" value="TBU20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M383"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0039p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="588" mass="68045" checksum="8D2B60065F6CEDFC" modified="2019-07-31" version="1">MTDPTVDEGINIGLSCRKTCYTSVENILNRLHNGIGVEEKQKLQSIINFYMDFVEENTNINDHSFLLKFVSFICYIIHTSDSKNNYKCYSELLFNLIGFGKLYCIFRDIGSKSPLESLTTDLFLDRLNAYEIAHNRNSAIDITSLEANAPVLCKKIKQSCFEGDGMDRCIWENITIQPDISKSVASKLSNFLRNASFDRIFLFYLTIKTYFFLINKETLNNQNFEFKQFNIVLNETFYEQLINLEEWFVKKYSAIQSSEKQQNIMKHISRGLFDEVLNDSITFDSILKFSTLDISKKPTSVDENFPQEFLELFTGKENATELENIYSILKESIRHAYHKYIPIIICLKCQCLKHSIPNSNKLLQIIIELMFFTKILILKNREYEESDLKVSLEKEYLSCLKNIIVNKKIVCEKDINGDPVLSKLVPKTLNLVNTVVHVQYFANNGFLSKLRDSLGGKPTKQNIEKSVSLEDMLKKYFSVFMENELKDVPIEISPTIVKESDILQNKPTTTKTDVKSGKEQPEQITKTSKNKKSDMNSSASQDESESQQKSKKKNEYDKWKIVLMLCSALTFLVVGCLLGYWYFVRKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3D1</accession>
    <name>A0A4Q9M3D1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0031p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3D1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0030"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="518" mass="60156" checksum="5D277DC7861A7987" modified="2019-07-31" version="1">MSAKSKAIGKNIERVFSEELNSTAPIVEDTRPSNLRILISIILSIVSLCGSIFCLHKYKYTNLSAEDGFEYNISILGFYVIFLCCIWFIVDIILMLIALQYLKEDTPGFVAIAILENQFFFKVVFSVLIYSILIKIILRVTSGDISGAEDEQVFENTAFAINEDKFSSFLLSAALFISIFLIERIILQFVNYRIHFMYYRDRIEENEKHIKYLQSLNRLTGVRINRDLTSWAKYVYDCISNGKEFLDVNDFKYYFGNQDGEDMFRMFDIDNSLSVTKDEFVSCYVSLFKEKQKLQSSLNENDECMKKLAIVLTFLAVVIASFLFFVTLGAKSQFTTIFGTLTGFVLPLSFVFGPVLSEMFQSILFIFSVRPFDIGDKITVGGSHYEVREMGLLYTTLTSDSRYHNFPNEKLRKEPVINLRKSMYITETYTKKFDYNSCKEKLDELSNEISKFLKENPKKYKSDFSISDYEILEKDVLKVEIRIKLSCPYQDIKAAKERKDFFTLFLHETIIRLGIEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3D5</accession>
    <name>A0A4Q9M3D5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0146p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000146">
        <property type="protein sequence ID" value="TBU20026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3D5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0146p0010"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1026" mass="120195" checksum="68F6E456DF3FC233" modified="2019-07-31" version="1">MNSSRFLTYMFNKIITDKEIPLIWKKHMIQPIHKDDSEFRPISLIEKTRKLFEKLIFSKFEHSTLNHALTLDTRLRHSDVEGICVTLDFSKAYDSVYRKRLYEKLMIKKKFSREDTILIAALIENNEKCFYNASTDHDFYVDGTRLEKQVPLKYLEQYYNKNIPMKQDNLEPQGIPYEASWKYKDEIHEIIANIERHAKYNSYLLNAKKCFYNTNITIEIRVNNIEIVKKSPIKYLGYYFNLKCADTKKNLKIARTNALKATAILKSAVRKNIFNNSGDIFRYMLRGYISYVRPHIDYPITLLGLNKTFTEDCDRIQKGIIKNLFGIYYKTPSKIIYGIFSIEKKSKEILNGKRTNLYTNFLNNNTKIFKTMKKLYFEHINEEMVQGTTIKFSATITKPKKKNLQQNLEIFNNFKNLKNFNWNTETKERLSKLLEVVNFEKKKKKFEEILELMNDKKIKSTIKVSDTILQKRVEVNCFCVYLNKSFLFHPNPTLLNQNLYLKDTTPIANLIQNNKYMISNSKECSQIKTAALGLPQGSILSQSLFNVFINDIIHFIPEEIRKNILLYADDIVIFSERYDYIRKMIKCVSKHAKFNNYILNPKKCFCNSGKEINLSIYNTQIERQNPLKYLGFHFNNRCKLNNEKTTSKTDLRFKKEQNIEQKCKKSAVNITTKESILLDILRNSNPETNRFKASLHVGGLSDLKIKKINEILDKNTFDILALVETWRDTFTPISKKYAIAAVKLSIRVDYIFSRKKGTIILITKNLTLTKIDNITEIEILQQNLINYKYLNTLIMGDYNLEQKPALEQEILDNHLHTNVDLHNELGKDIKILKKRFDKKRCSEFRTKSYRFHGLPISKINPNLNELINKFILDGPLINPDKTVENITDFYNKRQNNRNFNLEDKINGFTTNEVIGKIATLKTGKSDTDDFRPNFSIEKTRKLFEELILSQINLKIHKQQSGLKPGYSTLNNAMVLETELRHGNGSLICVTLDVIKAYDSVNRSELYHKMLSNQNLSLKDTTLIPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4C7</accession>
    <name>A0A4Q9M4C7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0077p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4C7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="62" mass="7372" checksum="E280FCABDFE922B5" modified="2019-07-31" version="1">MEVFRGRKDKIALGFNEFLENTFQNMEMPSDEDQVAFENKVSNKIDSFQQFNLNIETNFYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4K9</accession>
    <name>A0A4Q9M4K9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0034p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4K9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0080"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19220" checksum="75F1114105D6C491" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JU53</accession>
    <name>A0A4V2JU53_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative subunit 2 of cleavage stimulation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1591p0010</name>
        <name evidence="5" type="ORF">CWI38_0184p0010</name>
        <name evidence="4" type="ORF">CWI38_0572p0010</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001591">
        <property type="protein sequence ID" value="TBT98801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000572">
        <property type="protein sequence ID" value="TBU12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JU53"/>
    <dbReference type="STRING" id="1176355.A0A4V2JU53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1591p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0572p0010"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="214" mass="24240" checksum="9579163C553CD8D9" modified="2019-07-31" version="1">MAKGCSVFVGNIEFDIPEQKIVEELSVIGKVVNFRLVYDRNTGKSKGYGFAEYESSLIAETAVQKLKISFNGRPVKINYADTDFPIKSKETTATETLDIENIVNVLDDLDKTNLKDVVIYLKRMAIDQPSNFKNLMATNPNLLIVLFEALVKLNIVDQSVISTLLKKSFDLDEQKSQIFERICQMSDEDLSLYSEDVKNKISKLRSLIIKKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVX3</accession>
    <name>A0A4V2JVX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative PAP2-like phosphatidic acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2712p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002712">
        <property type="protein sequence ID" value="TBU05752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVX3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2712p0010"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="219"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="418" mass="45928" checksum="CA9CA207028D8F53" modified="2019-07-31" version="1" fragment="single">SIEEGVNYKSNYKGGNYKGVSHSSKEEGVNYKSNVLKGVSDSSVLECVNNSISIEEGVIYNNNKQQVVNNSISIEEGVIDSTYKQQGVNMKSSKEEGVNNSISIEEGVIYNNNKQQVVNMKSSKEEGVSNNNNKQQVVNNSISIEEGVIYNNNKQQGVNMKSSKEEGVSNSTSKQHPVIDKSSKEEGFSNSTFKQHPVIDKSSTNNPNPDNNIAIYLLLLYFITSYTLNNALIGILKIIIGELRPDFIDRCIPVLGICTGKPFIIREGRKSFPSGHTSSMFCSIVYIILVIYKKYGGDSYSKELEGMEEGVNNIIDDYKGVNTSSKLEGMEEGVNDTIDDYKGVNTSSKLEGMEEGVNDTIDDYKGVNTSSKLEGMEEGVNDTIDDYKGVNTSSKLEGMEEGVNDTIDDYKGVNTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX26</accession>
    <name>A0A4V2JX26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1938p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001938">
        <property type="protein sequence ID" value="TBU10212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1938p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9392" checksum="BF2B44294E2D6827" modified="2019-07-31" version="1">MLVFNLDLSKTNDFSETLVKKNESLNVYQRKLTMYENRKKFRRENRVFKISERVTYDDYLIPFVSDTDQATCLSLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX38</accession>
    <name>A0A4V2JX38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1896p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001896">
        <property type="protein sequence ID" value="TBU10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1896p0020"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="173" mass="19968" checksum="349F369D280E6F27" modified="2019-07-31" version="1">MIDFVCLVSLSILYLKVSHLFKKLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPTPPLKEEKREEDGEKNFKQKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEEEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD0</accession>
    <name>A0A4V2JXD0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1262p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001262">
        <property type="protein sequence ID" value="TBU11332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1262p0010"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46483" checksum="AD07C830BFCB1E69" modified="2019-07-31" version="1" fragment="single">MFEFDNVKILYLNPTRSSFEEVQRKLIQELNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRLGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKTAIIKMENNNKTHLAIIKGFLKVKYRLVEEVTKKSLGEAQLAKLSNEIEKRKLHSKLYNARKNELVNVSDSSRWLKRGNIRPLNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQKILDNEYAEIRVDTRIKTDIKIRNNRPDIFILDKKKNKITLIEVGITFQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSYLKRLEIPMNVEAYSQSIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY0</accession>
    <name>A0A4V2JXY0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0384p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXY0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0010"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF36">
        <property type="entry name" value="TYPE A VON WILLEBRAND FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="4">
        <location>
            <begin position="429"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="3">
        <location>
            <begin position="526"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="89070" checksum="35E03D73B3F3BDAD" modified="2019-07-31" version="1">MNSPIKMHKRNNIIRDGKSQVVKDFPKGYATSQQTKTEKIQNELPKPEVNAPSLPSEVEKDQKIFFSFDTSSYPPPLSTTDFFVTETKNTDPNLLRSSFYVIPAEPSIFQSINLPLTTVLQPFNSKALINEIENIKSVRCMECLAYVNIFTKIDDLGKYFKCNICNASVELKGIITKEDPILRFSTLDYLKKEEEIIYKPNFVDSEYFNYKFYKRPIFIFCIELTSSSISTGLFDSSLDSLESVLLNRDFSILYESIAIFIFGREIKNFCFENEEVAEYVITDDINTPFVSTSLLISLDSEFYDFKITKLFEVLRNLKSKDSISCLKNMLNVSCMLSCMTPGAITLIYMTHLGQIGDFSYLSNNITEMTSKFLNSSNSLFISSLEKTTDNPLIRLCFNCNGNYNFYKNLFELRKLLVKDVNEICLKQRGFNISIETRTSDSIRKSSVYANTSSETTLSVFISQMSDSDTVAFSFYIDESVKENTILYLQITVNFIDNFGIKKVRVFNHSFISSYKIATLYNNLCFDTIFCSFVKFLMNDTENLKKNLENIKNMLIKSLQFYRTSCSSQATSTQLVLPESIKLLPVLFQSLEKHKFIANEISYSDFRKIINFSVQKNLRFFYPRLFSLTDYFVEENLKKVNCLRLSSQNINSNEIYILENSLKIYIYVGRQVEKELIISLKIENLEDLNFYNFCTENEENENISEEALVLKNMIKEIKECYDKEMEVVVIKQGNGQIETEFLENMVEDKLNNVGCYGDYLCDLHFKIQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY5</accession>
    <name>A0A4V2JXY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EMG1/NEP1 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0400p0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000400">
        <property type="protein sequence ID" value="TBU13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0400p0030"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="22662" checksum="91E90004EF1A17EE" modified="2019-07-31" version="1">MEKIIFVLEDAHFVSRKNKQKKNTKASIKNNEDRINNRSDITHQCLLSLLDSPLNKAGKLKIYIKTVQNVLIDVNSEIRIPRSLNRFNGLMDELLKRMKIKSENGKILLKVIKNPVTEYLPPNIIKIGLSQHGKQLEKDKIIDKLENGYCFFVKAIPSGKDDFEFAEFLLKISDYSLSASVTVSKICHLFEELLQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA8</accession>
    <name>A0A4V2JYA8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0082p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000082">
        <property type="protein sequence ID" value="TBU20373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA8"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYA8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0082p0020"/>
    <dbReference type="OrthoDB" id="2190927at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="344" mass="39653" checksum="56240B23D9F311C6" modified="2019-07-31" version="1">MILIFDIEHPFTHEEYTSIFNTLLSMILIFDIYHPVNDDNKTQSMWDPVVANPEYKVKNDILSLQGFYESHNVPSIHVKTYGDLNLLTVNIYRDIIEKHRNITLKQELKAMIDHIHPTIFTIQGVDEEILSELGPMANSHYKIVNNDRSTGDFNSGKRLFLPIIYDSVMLELKDHDYFYTTGETKNIYASFAIFKNLRESSSEITAINLDLVSSYKEVNFAYLSNIINDIIHDPRVNNDIVFLMGGIGAVNKDITELLKKEYENLVDLDKNNINLSHTTVHANLVQDDDIQRDFIILRDKKREMELNYARILKEANFLGDHFPVNAILSFTGQVGNKTTIYGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL7</accession>
    <name>A0A4V6MVL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1040p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001040">
        <property type="protein sequence ID" value="TBU11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL7"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1040p0010"/>
    <dbReference type="OrthoDB" id="2195336at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="95"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="336" mass="39750" checksum="FC9CA2BF8CB7A880" modified="2019-07-31" version="1" fragment="single">AYIKKIKKASLYNTKNNKYVLDNKKRIIIKKEMGEDLIQDIHKLSGHRGITIMYNNLKNYIYIKDMPKIIDKIVKKCKKCLEYKANVFKKDKSNRIESEGRFERVSTDIFGPFNLSDYNHHEKIDIGYFLTITDIYSRITKIYFLNNVKTKHIINSINDWITKFKSPKIIISDNGRQFISTEMKEYLNKQNIKQLLIPIYSPGSNGISERINKTISFMLSINKKKDIYEIVKEIENTINLNYNSSLKCSPYSIIKEYSIYDPLKRRVEYDCTQHNNIYSNKSKPALGDMVYVKKYLSTKLDKKYVGRKKVVWISKKGYWVRLDGDKHFTHIKNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KTL0</accession>
    <name>A0A4Q9KTL0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Frataxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_2363p0010</name>
        <name evidence="5" type="ORF">CWI38_0226p0060</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002363">
        <property type="protein sequence ID" value="TBT97299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000226">
        <property type="protein sequence ID" value="TBU18876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KTL0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KTL0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2363p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0226p0060"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT97299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU18876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="109" mass="12583" checksum="0B8091A49832715C" modified="2019-07-31" version="1">MIPNTLPHTLYTQLANKTLSNIYDYLDNQNIDSTLDYTNSVITYKVAGIGDYVFNKQPPLQQLWVSSPLSGPSHFECKDKQFIENKSKEEITGFIKKEIESIINKRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KXV5</accession>
    <name>A0A4Q9KXV5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI37_1211p0010</name>
        <name evidence="21" type="ORF">CWI38_0675p0010</name>
    </gene>
    <organism evidence="20 23">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22 23" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FI-OER-3-3</strain>
            <strain evidence="21">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001211">
        <property type="protein sequence ID" value="TBT99802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000675">
        <property type="protein sequence ID" value="TBU12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KXV5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KXV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1211p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0675p0010"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="18">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="19">
        <location>
            <begin position="246"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBT99802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="436" mass="48384" checksum="C4E1448D72B97DAF" modified="2019-07-31" version="1">MREIISIHVGQAGVQIGNSCWELHCNEHGILPNGSIDPNSNQNDVGSSSSFFSETSSGNYVPRTVMVDLEPGVIDSIKNGPYKKLYHPSQLIHGKEDAANNYARGHYTVGKEIIEPVMEQVRKLADNCDGLQGFLIYHSFGGGTGSGFGALVMDRLSTEFGKKCKLEFCVYPAPRVSTAVVEPYNSILTTHTTLDHSDCSFLVDNEAIYDMCRNLGIERPMYGDLNRIIAQVVSSVTASLRFPGSLNVDLTEFQTNLVPYPRIHFPLAAYSPMLSKEKASHESLTVSEIAAACFEPQNQMVKCNPKNGKYMACCLLFRGDVKPKDANQAATLIKNKRINQFVEWCPTGFKIGINDRPPFILEGSFMAPVKRACCSLSNTTAISEAWKRLNHKFDLMFAKRAFVHWFVGEGMEEGEFSEAREDLAALEEDYMSVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZV7</accession>
    <name>A0A4Q9KZV7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1219p0010</name>
        <name evidence="11" type="ORF">CWI38_1650p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001219">
        <property type="protein sequence ID" value="TBT99779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001650">
        <property type="protein sequence ID" value="TBU10610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZV7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KZV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1219p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1650p0020"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="187"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT99779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="410" mass="46253" checksum="D53F8AE76BF1AB42" modified="2019-07-31" version="1">MSFSFTDPSNISLLLSLTKNYYGDKIKELETQIKTMYDSICIKLGTKEVETGLAPPACWDLNADRTRSQEEQTLQVARVCKIIPDTEKKYMISIRQMAKFIVGKSKKLSENQIKEDMRVGVDKTKYQIILPLPRKIDPSVTMMQVEDRPDVTYNDIGGCEAEIEKIREVVEMPLLEPERFIKLGIDPPKGVLLYGPPGTGKTLLARAVANRTDATFIRVIGSELVQKYVGEGARMVREIFEMAKSKKACIIFFDEVDAFACTRFEDSGENEVQRTMLELINQLDGFDSRGNIKVLMATNRPDTLDPALLRPGRLDRKVEFSLPDLNGRSKILMIHAKTMSVEKNIRYELIARLCVNATGAELYSVCTEAGMFAIRAGRKVATEEDFINAVHKVIGLYGKFSSTPRYLTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L5A3</accession>
    <name>A0A4Q9L5A3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0421p0020</name>
        <name evidence="2" type="ORF">CWI38_0630p0050</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000421">
        <property type="protein sequence ID" value="TBU02747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000630">
        <property type="protein sequence ID" value="TBU12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L5A3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0421p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0630p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16280" checksum="DE070E00B5A0D59A" modified="2019-07-31" version="1">MYRVYYKKSTTESIKQIEIMFLIFLIHVFCRDLKLKKYKYELKNIETNKNPVFYYDLPPGIGLENIEFTHDDKSFRIEYGKNLDDNKNGRFESVQGEYTKKVSYRLTNGKISVENGKLKVSFGDQDPENEDTTDNPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7T9</accession>
    <name>A0A4Q9L7T9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0421p0050</name>
        <name evidence="9" type="ORF">CWI38_0630p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000421">
        <property type="protein sequence ID" value="TBU02750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000630">
        <property type="protein sequence ID" value="TBU12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7T9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L7T9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0421p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0630p0020"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="200"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="285"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU02750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="455" mass="53551" checksum="A9630D839DD787EF" modified="2019-07-31" version="1">MVIQSRLCIDISKYTEINICSGLQKEFQGKIQIFRPTNENDFYTENLTSNTVCIVALPNYFKYSDLENFIQGFIPCYIRYFKNIDKNCFLVILKFETLEESSSFYKKFNGKLFNEYEPEICHVMFLGKIQCMINGIYTSLDDITTVEKDKAKMENKEIKDFELPNCPVCLERLDLSISGVLTIQCNHSFHCNCLFSWNDLTCPVCRYSYSREGLKCSECDIDTDLWACLICGNLGCGRYNNGHANKHFKEFDHFFSLELNTKRVWDYVSDNYVHRIVQSINEGKLVQVDGNIEKAEDIKNEYENLLIAQMESQRIFYESKIKDFKKKIYKKIKILKKKYKTQKKIKKEIQNNLNVQTDLQTKNTILSDENNRLLEKNQKFITEIKSKDILITKLQRSVNEMTNKIEKDKFSLKEMQDEIKELYFHIEKGETLKKEMVGGSLIIRKGKKHTSYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAY4</accession>
    <name>A0A4Q9LAY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0069p0030</name>
        <name evidence="7" type="ORF">CWI38_0422p0010</name>
        <name evidence="6" type="ORF">CWI38_0766p0020</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000069">
        <property type="protein sequence ID" value="TBU04943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000766">
        <property type="protein sequence ID" value="TBU12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000422">
        <property type="protein sequence ID" value="TBU13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAY4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LAY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0069p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0422p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0766p0020"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="176" mass="20266" checksum="013484EC84D096DC" modified="2019-07-31" version="1">MNLIIIGPPGSGKGTQSKLLSINLNLYHISSGDILRDEIKKEFGRQISVKIQKGEFISDTFMAEMVMCRIGEVEGGKGIILDGFPRNLYQIPFVTIEISGVIFLNVSKDICKKRVFQRNENRSDDSDIVFENRWELYERSTLEVVDYYRNKGKVVEVDGSRSKEEIRDFLVKYFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LE60</accession>
    <name>A0A4Q9LE60_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI37_0049p0020</name>
        <name evidence="19" type="ORF">CWI38_0107p0020</name>
    </gene>
    <organism evidence="18 21">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20 21" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FI-OER-3-3</strain>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="PITJ01000049">
        <property type="protein sequence ID" value="TBU05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000107">
        <property type="protein sequence ID" value="TBU20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LE60"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LE60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0049p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0107p0020"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="235"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="468"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="618" mass="69132" checksum="6FC7A5DD102B2C22" modified="2019-07-31" version="1">MIKEEEKIESFFSKLHIDDIPEKCVGKIHSVSGPVVVGSGMAGCAMYELVKVGHEGLAGEIIRIDNDKATIQVYEETSGLCIGDVVCRTGNPLSVELGPGLFENIYDGIQRPLKDIYESTKSIYIPRGIDISPLDRKKEWEFEALVKEGDILESGDIFGIVKENSLISVKIMVPPKDCGKVIFIAPNGNYNLNDVVLTLESHGENKNFFLYQRWPVRTPRPVKNKINGTHPLFTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIVYVGCGERGNEMSEVLMEFPTLTVNVNGVNENIMKRTILVANTSNMPVAAREASIYTGITISEFFRDQGKNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLAFFYERAGVAHCLGSPNRTGSVTIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSINWNLSYSKYYKSLEEYYETVDSEFIKYRTKCKEILQMDDDLSEIVQLVGRNSLTETDKLILDISKLIKEDFLQQNGYSSYDRFCPFVKTRLMLKNIIKYFELAYSVIVDSNSLTTWDEIRKKTNEVFLKLMKMKFIYHENDSEIEDELTSLKNEIDSAFNELDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEU8</accession>
    <name>A0A4Q9LEU8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2563p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002563">
        <property type="protein sequence ID" value="TBU06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2563p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="25945" checksum="D1AF560BB1EFE430" modified="2019-07-31" version="1" fragment="single">MSLIEEIERFQKVIKKRLNNSETYSYEEMEVVLTKWKNFEHLNGEIDRILSSVRYVSFDESFGSVQPKEFEIYANLLQYDDVDKNKFPIILNSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEW3</accession>
    <name>A0A4Q9LEW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2657p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002657">
        <property type="protein sequence ID" value="TBU06025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2657p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9336" checksum="A75BC5B6A68E0911" modified="2019-07-31" version="1" fragment="single">MNTEERSEMLLLNEKLNKAIEEKSLLDTKIESIEKRISLVELHKNAILDCICICDGKDVMKETFSDTSSDLFSLEKDLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGA0</accession>
    <name>A0A4Q9LGA0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2517p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002517">
        <property type="protein sequence ID" value="TBU06726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGA0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2517p0020"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="610" mass="71827" checksum="99DD50E71720402F" modified="2019-07-31" version="1" fragment="single">NIDSSLFEECIYVLRYGWNCNFLGIKKENFLNLISLIYDLKCYSNSDALLTLYKSLLTYIFVYLENRSFNDTFDLTKDDFITHKKHFLSFIYVLYDSIEVTYDSNNNELTFIEKKNVKKEISIQYHNVDEIIIRITPRALELIDQERHTNKSTLLNCIISVYKIKGIKISSDNSFFYESKNSDSVRNSAINKLQIENMNTSFISVFVCMRYIEKRELISIEFERIVVSEPDIIFLYCLPHLKTLTLVKCTCEDFEAFFRALYLNFPELQKLRFVRLTLLIDFFNNLYYMKIEILELLFSEIYIYKIENIKLSMLSKVLEVLSFKGIAFTNYEYSECFENWQKIFRSLILSYCKLCYTSLKFFSENIKAKKLYLNYFQTESQLVNILNHKSLHISTRKLSLCGNRIDSKLFYIITHFEFLEYLNLSSLKENSYNFYMSEHKFYSKLVDLNLSGNKIKEISFGFAKQLDRLVGLNLFNCNLKPGSLSDFCLGFMNNSLKRINLAGNVLHLSDIIQIGLLINLEKLVLSLDNKVFSEFIEKYGALSFQNLETLILILTNLDDAIINFIISQPSLKSIELRNCTIRDEHQIDCKLTPDGFQRRIFENSEITLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LK88</accession>
    <name>A0A4Q9LK88_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2231p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002231">
        <property type="protein sequence ID" value="TBU08679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LK88"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2231p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9332" checksum="6F7DBE91DC5F20E5" modified="2019-07-31" version="1">MDTNSNLQNQLRVIQFKSLFNYVCVIRVDTGIKTDVKIRNNRLDIFILDRRQKRITLIEIRISSQDSLQILEKKEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLX5</accession>
    <name>A0A4Q9LLX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2157p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002157">
        <property type="protein sequence ID" value="TBU09363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2157p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="16065" checksum="0CF8EA58D6025CAE" modified="2019-07-31" version="1" fragment="single">MDNRNKLKQSIRVDKRYSNKREIIVITRKTLREVIEEITDFGISIKYDNNLLFTNQKIIILGDYNLEQTRELEDKVLNNHMNYGLYELYLYANIYKHQNKISSPDKIFSNTPIRTDGIEIITINHKLIIAETFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LN37</accession>
    <name>A0A4Q9LN37_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2210p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002210">
        <property type="protein sequence ID" value="TBU08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LN37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2210p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="45740" checksum="CB2968225B6CBD05" modified="2019-07-31" version="1" fragment="single">EKLKCLLENKFSKAKKCDDNNSMILNDGYKVLAQEMNELCDKFKDKNKEELAKAVEDNTKEEIVLNILQVIKSKFFLLDCGEIFIPKFYKHLYIKSNRDLCFKFFGKTKDECIAEEKEKNNVYKRLQSMKQELEYNDNLDNIFVPFSNEDASSQYIQIFSSFCSRTAEIRTCLEKGKSNPTFFFSTILSDELKMFQPFFLFPGSILYFGIGFSEKIKSNFIDYAGIFNESQVVHISFIDLKPFLPEFLLNYSEQLIISENKYNLCEIIRKEYESISDNTKEIIKKTSSYGNIRVGFLHEIYKVYLKSKFFECKLNIYAFDISLDSFQEIYSKFLKDLKGKTKIFLIDEEEMEKCRDFFLKCILFKIKSMTDTFNLENLLSIEVTTIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNB0</accession>
    <name>A0A4Q9LNB0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2093p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002093">
        <property type="protein sequence ID" value="TBU09913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNB0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2093p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="22515" checksum="D4591A5042687079" modified="2019-07-31" version="1" fragment="single">MKRSIYIFLTQFLQFIESSEMYYRTSVPVYSNISTPNWHVDQISTPGLNLVYTQSSSGQYYVYNIQPLPSYQRYFQPFPSISGFGYVPMPYYPVPAYISSNQPCIQSYLSYMNAQPPNFAPNMPMSSNFSTFNDPEQLLTQDRTNATLLASSNLQMASESINNSTQPPNIYAGGIPEQNHMENPSVPTLTYIVLNKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPR1</accession>
    <name>A0A4Q9LPR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1956p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001956">
        <property type="protein sequence ID" value="TBU10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPR1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1956p0010"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18979" checksum="97C1DAB1648DECDF" modified="2019-07-31" version="1" fragment="single">MILEIFLKLKRCYIYSNEKDEIEQFKLFLNSVNLEYKETEEKNILSLNLTKNTNNLSDKLNTETEFEINELKCKCGNNFDIKSFNRLPTEGWQEYIDMWSCHNLEFKEVAKLEMRPRKKGILYSNFYFFINKNDFPCSCFQTENKNNINVFTNTQNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPR5</accession>
    <name>A0A4Q9LPR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDP dissociation inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1835p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001835">
        <property type="protein sequence ID" value="TBU10344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPR5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1835p0010"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="956" mass="105886" checksum="583FEA6330093346" modified="2019-07-31" version="1">MEEKYDFIILGTGLTECILAQILSLKGYTVLHIDKNSSYGSETRTLRISELEEKIQGISFSSSKCDSMCDSKCDNSKCDNSKCGNNLYSTNNTNTNNNHQHNHHPNHTNNNHPNTSLLSLDKHFSIDLTPKLLLSDGYMKKLLSKFDINNTVSFTHIPHSYIYINQCIYEVPTNERKSFESSVISLWQKPRVIQFFWNVRKYSEMRNGSRGVGVGGSGVGGGNISNNISNNTNNTNITNISNRVVNSSPCINTSNTNSSNDNDFISNISNISISNKDISNTKDNISSKDNTKDISNTNNTNNPLNNNNNTNTNTKNTKLFIFHGSTMKEQFEYFKLNTSSSDFIGHAIALNLDDNYLYKHPIETYDKIYTYVKSCTCYSSNSPYIYPLYGLSELSQAFCRKAAIQGTVYRLNTEIVGNMFGGGGEGDRGEGNGGDRGDSNGGDGNNKDIGNSKDKDIGNKDISYKDKDNNPNPIISNSKNPNDTNPNPNPNKCINNNPNPNPNKCIKTITNPNPSINNNPNPNPNPNPNKCIKTITNPNPNKCIKTITNPNPNINNNPNPNPSINNNPNPNPNPGINTNPNPNKCINTNPNPNINNNPNPNPGINTNPNPNKCINTNPNPTINTNPTISNTNTNQSPTFHLTLRDTLNNTYTNISVNNIISEPYYLPLLTYIKYKIIRCVCIIKGEVKIKNKNIESSQVIFLRGELCKVNDIFLVVLGNRECVAPIGYNVCIISMVWDEGGRGDGGSVGGSIFDSSNKGDNRFDSSNKDNNRFDSSNKDKGIFDSSNKDNNNIQDNNNIQDNNNILNTVAGMLGNVVRKYFYISEVRECKEKREGIYITNSVDHSTHFESIYKEVERMCGLLGVSDVLDDIEEMCGLLGVSDVLEDIEEGYRDVGYRGVLGRDVGYRGVLRIGVSYKVLSIIYLLISSSGNKGYLLINSSSNKRYLLINSSGNKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPT6</accession>
    <name>A0A4Q9LPT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2062p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002062">
        <property type="protein sequence ID" value="TBU10056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2062p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="18989" checksum="CF500F7BD6B7BE18" modified="2019-07-31" version="1">MIRYVLYGNGYDNREEGVNDRDRLEGVGDSNGLEGVSNRDRCGGVSKSNRLEGVNYSTNTLHPVNTNTTSFTLRNSFVFGDCKLSEILKYFKRVWNVDISMVTIRDTVVFCTFYDNERFKNNLEKLIRELCCKKEGDGCLFDFHGDNFPLVVADFREIEKGGIRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQB1</accession>
    <name>A0A4Q9LQB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit 8 of transcription factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1306p0010</name>
        <name evidence="2" type="ORF">CWI38_1593p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001593">
        <property type="protein sequence ID" value="TBU10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001306">
        <property type="protein sequence ID" value="TBU11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1306p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1593p0010"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="19969" checksum="856F9490F6823B2F" modified="2019-07-31" version="1">MEKILEKCILEELKRAGYQKFNAKALYMFTQTTIAQIKTNCNILSSLTLHSMRSRSTLLDVMNLIKLTKIDYSNVYNRPTVKYEVEEEPKPIQFKSSISCSAEKFIHIYDFMPDFPPVHTFKKSFLKENRSEDKSEKVKQRIEQSLKTESSLLKIIACSKGLPKRINFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRD7</accession>
    <name>A0A4Q9LRD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0310p0010</name>
        <name evidence="7" type="ORF">CWI38_2045p0010</name>
        <name evidence="6" type="ORF">CWI38_2245p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000310">
        <property type="protein sequence ID" value="TBU03342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002245">
        <property type="protein sequence ID" value="TBU08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002045">
        <property type="protein sequence ID" value="TBU10075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRD7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0310p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2045p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2245p0010"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU03342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU08561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="294" mass="33391" checksum="B035738145537FB7" modified="2019-07-31" version="1">MLSTIIKYVSFYIFLRIVPDFYNFFISKLKNKVVWNKVKGKWIIITGATDGIGKELALNAAKRKYNIIIMGRSSSKLDEVYSLIIKENVKCKKIICDFSKECITSFINDSIEIGMLINNVGCVGEHPKLFGEESSVSEMINVNIYNTFLLTQKVLISMMNRKNGVILNIGSFTGDMPCPVLSVYSSTKAMIRSWSESLHYEMRPYNVHVECINTGYVATKMSKIKKPSFFVPSAKTYADSVLNSFGNSSVSITYFPHLLMYSVIKILPRTFLGIITFFSLSRTRNMAIEKKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM7</accession>
    <name>A0A4Q9LRM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1339p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001339">
        <property type="protein sequence ID" value="TBU11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1339p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="190" mass="22774" checksum="C07463C73137A959" modified="2019-07-31" version="1" fragment="single">MSIFLLTFNITVSQQTVAIHFYENTDSTLKENFLKNSQSGIFQATLYKKYQIFSAELSTEYQKTFLIDLDTFYLKFSNEEEILDGKTYNIYINNSLLSYDEFTYFYNIVMSFPSFIDILNEYNYRLIFTIMNIFNFKHDKYFKRFIRLLWVSVVFNPIAMEKLYSKTSTRNEYEYPSCISKIALVELLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRT8</accession>
    <name>A0A4Q9LRT8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1545p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001545">
        <property type="protein sequence ID" value="TBU10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1545p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="10662" checksum="6EC64C99A2828A88" modified="2019-07-31" version="1">MGMQDFRCFRVPTSCRPRPCTPCFSNPCCRKPEVRNYFLSSESPCNDNSEKESLNVNIVLSQEDKKEENICFHMNVIGDPAGKPEEEEPEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV1</accession>
    <name>A0A4Q9LRV1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0315p0010</name>
        <name evidence="12" type="ORF">CWI38_0354p0010</name>
        <name evidence="11" type="ORF">CWI38_1309p0020</name>
        <name evidence="10" type="ORF">CWI38_1409p0020</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000315">
        <property type="protein sequence ID" value="TBU03315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001409">
        <property type="protein sequence ID" value="TBU11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001309">
        <property type="protein sequence ID" value="TBU11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000354">
        <property type="protein sequence ID" value="TBU13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0315p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0354p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1309p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1409p0020"/>
    <dbReference type="OrthoDB" id="2186115at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU03315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="234" mass="27838" checksum="9035ED86963EBFF4" modified="2019-07-31" version="1">MENKIKQKTDINEDTFVQREEPTLLGYQKLNNSTYTIDLDSPELRNIIDLDLTILNEDLENKIFTMLYHSREIDLQKCEQSKNEELELKRYFLDSQLCYSCGETGHTERKCPKRNTLVCILCSRTGHYKYNCPMLVCIKCQECGHRANACQERTDRRRFMMCRQCSGEHNITECPRKWRKYFYNRNLNNNVPVNKACPLCCGKNHFIDDCNVKKTKFSIFTSDFRRQTTYFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY6</accession>
    <name>A0A4Q9LRY6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1887p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001887">
        <property type="protein sequence ID" value="TBU10270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1887p0010"/>
    <dbReference type="OrthoDB" id="2196203at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="343"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="504"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="984" mass="114587" checksum="6F1C1BD6EBBE413B" modified="2019-07-31" version="1">MENLLSQLILEYYKTTKKNTNIDQSLLKYLSTLLSLSPRIIPPDTLSILSPITFPIPTNSLSQIEIQTFYFLLKISQFHPKKTPKISTLNIKKIALGINTYRGEERITNINKYEKNTNNNRPITNTNTNNNRPITNTNTYALDAHVIERASYYGKIYKELKYHPRPTTITHQYFYKAIEDILQTYENIVLSYNNDQPILIFHTLMYVAYNRLEALNQICQCYKDNTEDSFSFLRYLNINLLKGTSYLYDSNDTFYNRLISPFNYKNMSEGVSYKYNSNNTLLDRNKSLKGVTYSCNTNNTPLNYSTINNTPQHTNIYNNTYTNNFPPLNIILQKITLYTSIRTNTLLSSWLYTGTFIDPTSEFFIKVNSLENNTWHKFSINTKKVPYFISPHCINNILYIGRCINLIKEVSKNKNYPTNRENNFNNIVDENIDNRFDKNNFNIHNYSNNYSNIHSNNHTTNTNNINILDSDFEETINKILLQINRSVWSEIFINSKVLSFVYFLKDIFMFKRSDFVQNLFEMLKEWNVDKYGVSYKRSVGFILDTSLGVTFGNECPFIKYMDVCLLEQNRGISRDVGINDKDKGVNDKGNKQQGVSNSTDKQHPVNYNNDKQQGVSNSTDKQQGVNNIYNKQHPVNYNTDKQQGVNNVSNKQHPVNYNTDKQQGVSNSTDKQYPVNNTLYEQHPVINSTFVDSDSLITNSVNTTILENNNNINNTPLDNTWDYLTLLCVIDFPLNMIINKKTILRFSTIFKFLWKVKKVERILGSLKKRKLDKNSLNRIHFYYCFVQSFMFYCCEEVISIEWSCFLRLECFEENLYENKSKNCRYTNVEGGGVNDRGNLEEGVNDRGSCIKGVNYRDSAQQGVSKNIDKQHPFNNSIHQQHPFNDIYHNPSINNSTLMNSRLIESFKDGLLDLTGKIIERGYMTGRMKEKLFLFFSELEALSVKVGRTGQPFDDFGVKKCLREFYIELGSRVENTGLFIYKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS37</accession>
    <name>A0A4Q9LS37_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0946p0010</name>
        <name evidence="10" type="ORF">CWI38_1244p0010</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001244">
        <property type="protein sequence ID" value="TBU11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000946">
        <property type="protein sequence ID" value="TBU11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS37"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS37"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0946p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1244p0010"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056326">
        <property type="entry name" value="ISD11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23511">
        <property type="entry name" value="Microp_apicomplexa_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="307" mass="36289" checksum="5C2C8DA85728E1B6" modified="2019-07-31" version="1">MNNNDPSVLYANLLKIISKFKSQNFREYFSRKANEDFEFLQSELEKGKNTCAIKKYMEEQNNLMDVLKRQTKIYNLYNDKDSNFPFLMNVEMGKDVVKDYVNKGMQRVNFAKVRPYFNITNKYVLMKLIVIIFPFKNKEWHCAHHSDVIMADSMKVSDPDLYIPIMSFVTYILLIGLNMGFKNNFNPERLGIIFSRCLILELVCMSIVKLVGYFMDISELGLLDFLSFSGYKFVVIILNLLFKMKYLGVLNYNLDKMPKSDENVFRDVLMNQKGKQDDKMIEIKTLTKCKKYVRLRRIFLVNNNEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ4</accession>
    <name>A0A4Q9LSJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Paired amphipathic helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1723p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001723">
        <property type="protein sequence ID" value="TBU10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1723p0010"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="32802" checksum="DB252ADA6E88706A" modified="2019-07-31" version="1" fragment="single">MVKDQEKERSTHTPDYTEKKRIYPEPSPSRYSGIPGNVMIRPGPPPVKFVPRMSKPPKTEEPDLNDALMYLTQVKEEFKGDNSSYDEFLEVMRDYKQSKLDAAGVVSAVSSLFRERKHLIQGFNDFLPKNYRIDLEAPPHRIPLPPKPYYDSYKRPIPPFARPPFKPQEDDPHKQRMAFDYIKKVKRRLEATPEIYSNFIQTLNSYRNTQEPTHQIVTRIKKILWDHPDLIDEFIEFLPSHPHPPPPHGKDRERQESFERIKLIMKEKGIYSEFLKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM0</accession>
    <name>A0A4Q9LSM0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1586p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001586">
        <property type="protein sequence ID" value="TBU10721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1586p0020"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="38909" checksum="93CB16B5058B7DD1" modified="2019-07-31" version="1">MDSESFKWSVLLQNIDNMSIKTLQYTPMGYGSIPENRKIQEYIKNGAINLDKPCNPSSHEVVTWIKNILNVEKTGHSGTLDPSVSGCLIVCIDKATRLVKSQQSDGKEYVCVIQFHTETTEKEFKKVLKKLTGNLFQRPPLMCAVKRNLRLRNIYKTEFIEFDKENKKGLFKVSCEAGTYIRTFCVHVGLLLGCGAHMLELRRTKSGLLNESTCVTLHDLKDAMHVFKKTGEEKYIRKVIFPLENLLIKYPRIMVKDSCVGSICHGAQLTLPGVLRFDNNIEIGTDVVIITTKGEAVALAISTMSSPEIHIANHGVVCKTKRVIMDKSTYPSLWGNKDDVFMLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ5</accession>
    <name>A0A4Q9LSQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1130p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001130">
        <property type="protein sequence ID" value="TBU11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1130p0010"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="606" mass="70243" checksum="64B9CB71A9F708DC" modified="2019-07-31" version="1">MNSIVFADIVNDAHNYRTRYFNQTRPQEAFMYFFGVLNASLDACFIPNISVVSIFRKRNQYIDQCFRYTEEIQNLVLKISADSLELLMATPSFNMAIFNWLLLITKISGFYFDNTECSFNPIKCPNVCGFIKINVPKKSPNSLKAVSSTFLLNLSDVNKRRIAHLRFINVDFCFDKIQNIFKENNVSYFEVAYCSVDECHKITEFLLKMTEQNIFKLRGVEMKPDDVDRILRSKVRILVLDTCTICKDTVWTPNKSPDFEYEIIHYLQTLNVSSSKLPSDLMQLLLHSFNLENLNISCFEFLPANSSSSMIGLKRKWNCLQIDKYIPSDYLKNLLKEYSVYSLSLCESFIFNDIISFFNTGYFNNSVKTLDLSDNSLTVDFLAIIDNFKNLKRLNLSASLPLSIYSPSNYRFFATLRDLDVSRNNITSTNFEFLACFTSLRSLNISESKIEKGLFTKMLTVELIASLVSLDLSGVHLEFSDFKRFLPCKKLKCLYFKVANDRSLSYYVDILVFTAIKKSLNVLNVEIDRNISIDDLVSLNGLSNLSEVKIICNAFLFVGEENLIKFDFFNPEFRLELCLRHYNLDMYTIEILKEMFKNYSFSIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR5</accession>
    <name>A0A4Q9LSR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1107p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001107">
        <property type="protein sequence ID" value="TBU11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1107p0020"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="364" mass="42665" checksum="F8D33C8D2B06E2CC" modified="2019-07-31" version="1">MTNIDGFYIETSNILKEIIEKGGTIRNICYKKSQPAKYIALLQNVLTNYRKIKSIVKETGLFIKNKYLSVILCYEMLENRVFLKEYSDLIIKIKKQNIDLISYKPKKVFVRINKLKKNTNVLEGFDVLRTDIPDVYEILNDTLLYRNEFYKKYFFYIQNVVTCIPPYILNPGKRSFVVDCCAAPGNKTTHLSMLMNNKGKICAFEKDKQRYKILKENVLNSGANNINTKCMDFLRTDPLDYKEVTHILADPSCTGSGLHPYYQKNTERIKKLSNFQKMLLNHCFKFPSVHKIVYSTCSIHEEENEEVVKEVLEKNPDFKLKKIRRMCSGKRGNKSYNFYKKVLKFYPSLELGTIGFFVAFFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT20</accession>
    <name>A0A4Q9LT20_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1212p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001212">
        <property type="protein sequence ID" value="TBU11427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1212p0010"/>
    <dbReference type="OrthoDB" id="2188332at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="333" mass="38396" checksum="D623931D1AF4CE84" modified="2019-07-31" version="1" fragment="single">MSSLKNLISQSKTDPSVLSELQSQLKLLITSQSIDPIVELLTSESFDHQFYGLVVTEQKLKHLKLINSSVQPIHSLIEGYSSIICGENRDISNIPPFILNKFSDIYALLAIYDWPSNFPHFLPLLTNLFQAKHPFSYNIFEKFLFQVNTNTDISEKRRQELKKSISSIFPEVKPYLIDFNTNSLNIVNNILDIYINLLQIISPNSLPIPNIFSLASLNPNKSLFLIYELTTLVDMRSFLPEIQKLIFTLSYNSRLVDIFSILLNHNRYKEITNFQKISEYAISGFQGSSYDMESSLNFYNILFKRKDITDTPEFIKFYENISACILSNLIRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTA2</accession>
    <name>A0A4Q9LTA2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1071p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001071">
        <property type="protein sequence ID" value="TBU11714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1071p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020464792" evidence="1">
        <location>
            <begin position="20"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="522" mass="61340" checksum="22FB09D311FCA56B" modified="2019-07-31" version="1">MIIYVIIILRNVLCTNSDAAKQSDTTDFDLEKQFLADAEAFRIAQPNDHANKYLHIILTNRYRDCCDEASLGLAYAKRLVDVYLQGVKSLVEECFPETIKKQKEIVRRQNHGNLTNQKTIYESLLSIFIDIFIRKYLDNLKPQNILNEEELKMYKESFSLQKDALLLDPDDFYLLKLTKTPLLTKKQKNEKIDANMIDKTFRAILIKKVFILIVKCFKNLSLNFSELSVYDIEKNTETLKNEIDKNAFINNIKKVYKKNKSKVPPYYCVSSRSSSYLNIFGTSMKNVYDLHTPEIVSNYFCDEFPDDFHINNFTMSFNYSNIHALYPYKMDISGEVFPKSMKDCFILAYNAYSSKVAPKKVYLTIFLEIEIWLDIFIDQILSELEDKYLDIIFGKNFHIDTDKRSRQIKGFFENKLHLKPFSDDIKSFLEILKKQLRLPTRIFIYIYKPKDAVFEGFRNKPLEGLGAKEVASLRILKRRSLEENKKSVMHCFKHCFTSALTEYLETDGRIIKKKYIEFEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTE6</accession>
    <name>A0A4Q9LTE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1505p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001505">
        <property type="protein sequence ID" value="TBU10865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1505p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="410" mass="49390" checksum="C6E96526247B6B16" modified="2019-07-31" version="1">MYLCLISEKLKWLIFLELFVISLSQNFIINSFESKFESNYNLFKDLFEFLNSKDIYFYEIFNSSCTTSLIENIEALELSEDTNMFHLYLKLKNEIGCFLNKRTYLLNFIFYESISLRNDKIKTSKNQNLMIFNKKKPLLLLYRTALNILLNFMKIFKKIENILIASEIELVLAPFLLNEKDFRNLNFFILRQIRSSSSIFDFFILKKSKFFAINIGKQQIKQPINHNMPSSVLYILNETKYRFHEEIEQRFTPNHILNEKLLNIEVYVNTYTIVERNAKNKESYIHESHKKYEFFNYIKKTAKNIHENHNSNEFIFILFGSNAVQLKIDVKEKHLTTNKMYYTARITFIESILFEEYFFEFDEVYSKIGDIKSKISTTFEEFQPEKVSNLESLLYRITFYKFWHLYQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP4</accession>
    <name>A0A4Q9LTP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1157p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001157">
        <property type="protein sequence ID" value="TBU11526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1157p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="941" mass="112735" checksum="7C81333D7F2CAB2A" modified="2019-07-31" version="1" fragment="single">MNIYNDFFLIYLIKFSINLILNVNIGKESIVFTFFVKFVLGREIILVAKEDLNNSSDNFTFIDENFIFGYKKNDTTVLCPCNHEIFTIGIQCSENIKYFHFKLRKIIIQNPDEYILNSELIRKINDDFSMSNIIILDMYSYSEVKEYIKYLQNIDLAMSDISINQFSKIINFINELKFIDCKHINELISFIAFNTFIVRKEELKYDLKDLENIEKEYFSVKFVLKIFKYCFKFYFRNIEAIKKTIGINTESKNSLYTKLIKYHNKNEIPIIFSNETSNLLYKILINRNLYSIIAILFNRLNVKCLIIYGDNLHYLVPNYIFLGILPNRINKCRFIIIEQRIEYLQNYFKKFFNRTSLKKIELTVNYLTEAFIEALGNLQNLDFLKIGIFEYNNVILNSILKLLDRSTTIFIELTLRNIDFHDIFDSNTYKYLEHYQERISFGIFTKDLRNLKIKFKEIGKIHLITGLKVFLDGNLAKNEKYLTKLFSLKTLSINFLFKNQFFIKSKFLFLSKLDKIKSIRMSNIRINNNLLKYILFSKNLKRIYLKNVTFSTKINFLKYERYKNYTLEEFSLDKTENVPSGFFSQYLNRFPTVYFLNCMLIQTEKLILKFTLVMNNLFDSYKPDTKNISHQEYTFFPQKLHLNKVFFDSELFERLFMTDWNIIYLEEIYLEDLKIYRENLMHFTKINALQIISLHSVIFADSNFSDIFLQISNLTIQVIILKNIEIHEVDLLRLNKLINLKILEINFCNFSAKYINLLRYSHFRTLSRFYFRGYLFSKKLRNIFDENFSSNLLNVSDSSRWLKKGNIRPCNEAVFCYIQDRNTLDHLATRCEKMLGHDYTRRHNEVVRRLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNNITLIEVGITSQDSLQIVETEKLRKYDLLANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ5</accession>
    <name>A0A4Q9LTQ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1077p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001077">
        <property type="protein sequence ID" value="TBU11697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1077p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020325383" evidence="3">
        <location>
            <begin position="18"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="719" mass="84402" checksum="F4B1203DAF696D63" modified="2019-07-31" version="1">MFFHVFVCLKILHCFTGLNIDPMIEVYFRINLNLVLRQNDEIRNILHGISDEINESEMEKYVSVISYYLDIVKENINSVHHPLLTHFVCLIFYLVHHKDTDEPIIFDADLLFNIVTFSKLYEYTKCNREMNDIIKTKMIMLFKSGMETKENMKEILKSKVIRLNELETDCPLIINNIKSSFDLDNNMDFQIIKNMKVKFKDLQSWVYVEFYLKSGSFESIYSFFIYLKLCFLIEKWQDLNSETIGFSLNDFFLDSTFWDQLRALNPSLTPYIFLKFDRVTYKDFIKFISATWLNKILNESSSFDSIFEFSEEKFFYGTANISRKFPENFIEFFKVKPYENQINMIYSLLIDISKSEFHQYIPIVFILKFFCFKKVTSNSEILLRVILECIFYMHILSTERNNCNTFSPRKAYEDKLFSLLEKNLTSRNIKINIPVNRITLIQRYIPETFNFFENFILALEFANAASIIFFNRNFTCNLHAINRSASQDVYKNLKSYCKYLLDIELDKTIRLAPVTAHEHEPIPESITESDIISEYIPNSIPTSETKPKPKPKPKPKHRSKFLPTPEPEHENMIKPKTVPELLPESKLKHEQPVPKSIPKPGKIPISVPLQIIEKKQSKISPKDQNEKLASTSVGIKPEISPQTPSKIKIKNKNNRNKLENITKEDKDSTSEKETQSKTLEGKKKNIFKIILIVTLVFISIIGISAIGYWVYVTWKVQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU81</accession>
    <name>A0A4Q9LU81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1346p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001346">
        <property type="protein sequence ID" value="TBU11165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1346p0010"/>
    <dbReference type="OrthoDB" id="2187603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="804" mass="95901" checksum="E31C56242901D3BF" modified="2019-07-31" version="1" fragment="single">ESNDILLKIFEFVLSISNFRDKWILKLKINDIFVTNKIKVLVPQNYKNIVFSEDCKNIVSLAKEYLEKEIGKNITRTKIAAFCVICSIELDDQAIIELEMLDENIFYFIAYVFSNSKTKYEILLSWLKNLKIEEIELNLLYLENIDSMKFIINELNNIKDNNVFVSIIKHSKSHKLIDVFFSRLYESKYLLEILLITYKDEDHEYTNSIFSKIFAIDNNEGEKMLKRFLIETKSKYFSAMFFEKCKNVDSYYIEACLICSNNIDLIRDENIIKVSQSHYFSFLTSEYVIYEKCLRKLKKIFDEDKFEIYDTVKDKKYFIKNLCKRLFKEQIIIEAVSIKKILLFLELFPESYSEIFKYLIEVLIREKQFVKNNKLENIEINRSTNTLAENNTHKIITSQENIIICGFNTNDKNLLFTLIDKLRHDNRIINYIDILLGIDYEIYLENVVFNDSNILDLLFIESINYFISNMVEFDCKKKLIKKIIKYKHLSCRETYYWNIILRKNINTFELFDDSVLMDKLMAESIGKNLQEIDKNEMYFYNSNSNIISILINDIKNNHPKYRNYKLYDKILKKFQLENSYPEGLVFFDSSIIIERRMVSFCCYIIYFQTDVEAEQNLISLYGNLITTIGLKNARLFRKIQNGKQEETILLDQGNNHSKKINLSLSYNSGILLLYINEIKYKFYITDINKLIIGKNFKGIVSKILWYEYYGFKMEYTIEIPRSRYFIDFLSDLEKILIFNNHAGVYIDTLTPYFLSSCPIDIYISNIYKNSNFYWKQNTDLKNILLEESIKDQTIKSLYEKYFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU90</accession>
    <name>A0A4Q9LU90_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-rRNA-processing protein Tsr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0892p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000892">
        <property type="protein sequence ID" value="TBU12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU90"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0892p0010"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="1">
        <location>
            <begin position="315"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="579" mass="68090" checksum="88B10F1AF6C05741" modified="2019-07-31" version="1">MTTKFGQKKTKEIKEFLEYPGFYKVVSFVALSNKIELDGIIVEMVERYFEKNKKFQQKYITDESFTNNNYSFNGDCISFSCRKNENYLFFNSNNFTDREATYISRCSDLIVFFIEKEIDNLDRFTMLMKNLPSFLFLYLNKENKYFIQKNVEKYIPKAKILYKDDFLAQLPTIKTFGTRICENRPYFVPKMFLYDNINQILEVEGYMNQGILSDKLICNGELEFIIEEYIIGDKRFSNSEIKNICSQNYNINILAETDDLERHNLNIEGQNIKENYNEQDLDIEESYESTITEEENSNKYELSETEASGSILEDKIDLIEKYSGYRGIKNLSTCNLISKEYPDYYENLIFLKNYKGYEKYSKNLESGFGNHQIVKMKLRKNSNIEFNFKSVVFFNILEYEDSLSIFNVSFESNNLIKDFDKLFFDFGYKIIEATPILTNNSSDKIHKKLFETKSGVMTFIAPLCFNVPKVLIMDSSNNILATSTVFWFGDRNIVEEVTLKGYSIKVNKKSVTVKRMFSSKNEVLYFRNIDIHTRNNMKGIIKKPIGTHGMFKAYFPKSFKGESTVFMSLYKQIFPKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK8</accession>
    <name>A0A4Q9LUK8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0981p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000981">
        <property type="protein sequence ID" value="TBU11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0981p0010"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="80"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="532" mass="61719" checksum="1A728818A710E96E" modified="2019-07-31" version="1">MKEKLKTSQNEHNKDKLDYFDENEENKIINVRKKALNIKTKLEKISSVEVEGAKQVVEKFEQKLRIEWPVLFGENPKFIFVYVDLDSFYASVEMLKNKSLHNVPLAVGGNAMICACNYKAREYKVKAGMPGYIAKNLCPTLLIIKPNMEKYNYYSEIIMGILSKYDKNLEMYGIDEACLSFDKDSLNTAYNILSKKTDLKKKIEFENSCVLFTFENICKIVEEIRNCIFDTTGLTISAGISVCRGLAKLSSKVNKPNGQFCLKNNFQTYLNDLDVDELNGIGKRTKELLVRTFNLKKVKELQENIHLLYLSLKMKTFNILFRLSYGLSIFDGLRPVSYTSLSKKSINKEYSFKATNDYIEIINNIYNISKYVSKKMEKNNYFSFLISVKIKFSDFNSFTIQRQCKVPIKTIEDIFDTVIDLLTNHFSDKSIKQKLYESICNVNTIRLIGIKVSSLIKEKNFNLIQKYTNDMVICSERLCPICNLGFFNESNFIFESHVNICLDKQQTEKRKINKTLLKFFKSTNTEPNEKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN9</accession>
    <name>A0A4Q9LUN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0818p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000818">
        <property type="protein sequence ID" value="TBU12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0818p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="16496" checksum="FC89C0168C205599" modified="2019-07-31" version="1">MSPSENNMSFLRQSMSIDDTIALKSIASGNILFSSMNSGSSGKYPFLFINPCSAHLISCSAIMSILCPEITSDRHFIASAYEKNARCEKDVVEAEAKEASPPAQVSEEIEENIEEENSNKDDKNTAELKPVKNQGGFKHPHAHTRGHPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV28</accession>
    <name>A0A4Q9LV28_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0842p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000842">
        <property type="protein sequence ID" value="TBU12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV28"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0842p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="34755" checksum="75DEE78D8BB8C1C7" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANEADEVKKSDNEVQKCKLHPPAISLPSSTYTTITPPPPSQTCSKMQNSGFDTLPSPKSPVPSSVEVSACEPSYDMTSPCTLAILEGNRLMALQTIFDSVTADPKEWPRIVFFFAVQTRFERMPRNGWTELHRYYNEKFGCTGTLKVLKKLAQSEMGEEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISMKEIGKVVVRTRKHPNELVDSKVLDLINQVVGEYAGAHVPDSITEAAYIMQAAQICYDEATRKEKPRSAWKENIESKISKLVFSKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV96</accession>
    <name>A0A4Q9LV96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0861p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000861">
        <property type="protein sequence ID" value="TBU12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0861p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="544" mass="64763" checksum="40EC2723B639C9AA" modified="2019-07-31" version="1">MENFFSEKSRIMISPLNIAIFKYFLEEKILYNFLNLLFNAIKVRKLSFNCLTTKLNWNQTKFTNLIPFSCIEIEISMYYLDNSFIKYIYPLLSRFTTKKFKISVTEICLKTFEIIKILHNLQILCISYDSNTQSDRILKNIFQLPSYMPTTHISLTLSDSVLKDLYSFPSLLDNIKLRTFSFHLKSLKSISYLIDEIYRKFNLNFFFQTLAVRSKSPLKSSEYNTLKKFKFTKSFSCFFDTNTIRNCINQEFGFLSSFVYIKRIRISNIIIKDELLRFIFHSKSLKSVQFDKGTISEAMNSCYHFENDNLCLENFFIGYLDRPFTKNLLKYLQNFRKMKSIKISGYDLINSIIIFNVIFYDINDKILEFFDPEFIFDDYLYIKNLSMNKIMFNSDLINGIFSKKWNLSKLRKLNLEEMSLSKPDMIFLSSLVSLLDISFQRVKFLDCFFGDLLSHLILKKNCRLHLSEISLSKSDLIKFSHLKNLKYFELCFCSISNENLFLLRHLYLKNLNEFKLHVTGLTRCCRFFYKEFFAASILEILYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV5</accession>
    <name>A0A4Q9LVV5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0106p0030</name>
        <name evidence="1" type="ORF">CWI38_1032p0030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001032">
        <property type="protein sequence ID" value="TBU11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1032p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11644" checksum="4AFA82B161775F2C" modified="2019-07-31" version="1">MIRFFSGSLRKYGALKSPNLEFLILVFTNVNCDIANFVIMLSSLKSLNFVKCKLNDDVLIINFNLYPPSLKSITFTKTFIPENDRFFLDVLRNFGIQVIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVW3</accession>
    <name>A0A4Q9LVW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1051p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001051">
        <property type="protein sequence ID" value="TBU11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVW3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1051p0040"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="11764" checksum="C7A9F3AB0B118FB6" modified="2019-07-31" version="1" fragment="single">MKNLLEFIATAEDGLTETDILAGYPNATQEEIAKNLNILLKKKQIDIFNDGHTLKYKASLSTMKDEEKMIHTLILESGTKGCLVRDIKNKTNIPQNFVMKILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX1</accession>
    <name>A0A4Q9LVX1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0638p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000638">
        <property type="protein sequence ID" value="TBU12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVX1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0638p0040"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="264"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="420" mass="48119" checksum="38D4EF9A3B3DC86E" modified="2019-07-31" version="1">MIFLYEAPTGFVLFKKLNKEDSQIQMADYKKFEDPLSAISTFEVLTAGKVPTILKDFLKSFFCDSKDTLIVSDKKIVQELSSILKIKVESDSPEVFREIRKNINSYLNINDDDFRSTASCIAHKLGHHSLKIDPSKIDSLVVQTINLLDDLDKDINTHCMRLREWYGFHFPELSTFLENNQEFLRSLLILKRKEFIKEIEKNKMLEFMDEERFSEIERLAEVSMGTEISENDCERICDDARSVLKMFDYRNELNEYLVNRMQSVAPNLSALLGEMVGARILARAGSLANLIKYPASTLQILGAEKALFFALRNKSNTPKYGIIYHSSLVGHAPIPLKGKISRVLAAKASMAARIDAFSETKDNSFGVKARIYVEERMKQLEGKSKKKRIPQKTPKFKINPSESISKLKEYEENLAKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW43</accession>
    <name>A0A4Q9LW43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0737p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000737">
        <property type="protein sequence ID" value="TBU12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW43"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0737p0020"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1019" mass="118720" checksum="72F9A789AE43C40E" modified="2019-07-31" version="1">MQNNKKQKSIFEYFSSPIKKIQTETNNVSFIVSENENNILDNEEEKNTKKGIKNLPLNKEKKEILNKNKKIELKSKIRTDEDSDTVSLDSFSSSIMIDSLKTSQDRNQKTVSLDSFSSSIMIDPLKTSQDRNQKTPISLKESSQIDPERFSFLVDLRDKNMIRKGEPGYDPSTLYIPEVYFKKFTPFEKQYWNIKKEYFDTIVCFKKGKFYELYENDAEIGAKYFDLKITDRVNMKMVGFPEKSFDHWASKFLEKGFKIARVDQKENMIGKNMREREAETNKESKKSQEKIIHRELKEIITQGTVYNPEHLKSCFSIYTAALKIDYESMDLENQNKIISVSLILYDASINSVFYATFNETEDFSNLKTIFAKYEIKEVITDVNLKLDEPFIIIKPIKGNSDIKNKFKFSNEREYGCFMYLSNYMEYLKRSDFSENVNIVKLNEKSGGFLVLDSITLKNLEILRNNYDMTVDKSLFSAVNYCATPGGIRMLRKWILNPLRNYEEILKRQNITIFLNLIDFDQIYMKMKSFVDMERIIGKLFCGNSFIGDLVKFLNNLKFCCEIVEDLKTKIIKFSEKYRKENPSFYNYFIKSTKEEIDAKAEESIDLLNISDNFSIEDSFNRDERGCLEFYNLLKSFPSVKEILEVFYKNYCIKNEEISPGELKNDEICDLIEEMNLLENQLDENLQKEKLKLRCADLCYKNIGKEIFQIEVPNSVKIPENYILISSSKNFKRFYTLELKNMVINYMELEERIFQSRGSLLKRAVDSIAKYSNVFYQATSIISNIDCYFSFSKFSKIFKDFNFPFLGSKLDFLNMKNPIYTNYIPNDLCLQNERVMVLTGPNMGGKSTFLRSVCLNILLAHIGLKVACEKMEFVIFDRIFTRIGASDDLSKGKSTFMVELSETAKILNESTINSFVIIDELGRGTSTIDGEKIATMVLKYLRNKNIHTLFSTHYHKMIENISLIKKSYMKAVVDSKDIVFTYKLCDGICYDSHGISVAKMAGVPDIIIEKALEYKKELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG9</accession>
    <name>A0A4Q9LWG9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0863p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000863">
        <property type="protein sequence ID" value="TBU12181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0863p0010"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="91891" checksum="3DD2B224BBEEC8A7" modified="2019-07-31" version="1">MLTKRIIYRPSEFLFVVEGKHPSYHSHPRIKSAPPIPITPIVEPLIKPPTKESLDLVFADGTVLTREMVEDYNDYELSDEESLKEAKEPEKREEELPEKKEEELPEKVSIVEKSEAQNIVEISSSLQNLSIKESEETLKIEENPFIQATDITEEIIVNHEELTKETVEEVVEDFIPESIPKTTPVVYKFKKTINRNLPAEETPVYKFKSKKVSEVVEKQIPTHIYKVSDIFALTKRNPVEIKIDKNIFPKISTKVPHKTEFSKNKDDPVAKFRLNLNRVTDKNVRDVIESLIQQSKGLLKAASIAKMAQILFEKAVNESTFINLYAFMASKLNKVLMSDVEKKSEICDRTVFSSTLLNLVEANINETVLWETKGDDNLEKINKALEKIKLESRALRMDNVKISEETERENLEYERECILIEMKDRKMGAVRFFSLLYDLDVIPYNSLSLYVKKLFLDLTYENLEILSVIFEILASKLKTNRCSVQLFNEMRETLVKNKSIFDNRLRFMIDEILEKNDATGSSSKKLEASKITIGNDGSVKTSTISKPREVYRTAKKNIASTNRFSALKDLELESSDNKVELNSEPQILDKIEINSKPEILTKEELNKISFVRIKMEDFSSMDDEEEEWDLLVNDVAKDIKSNVISKEDWCKGFFVFCMESSSDEIVEKLVLWLKKLSKEINLPSEIKIGVEWASQVYPEMHDFPLAERRLYVLLVHLRATQSIDKSWFLQISNPLFKEVRDCILKKLAFNFKNRISIERIIENDSEFLSILSRIELQEELRNKWQSCFRGADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH2</accession>
    <name>A0A4Q9LWH2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0656p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000656">
        <property type="protein sequence ID" value="TBU12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0656p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="223" mass="26328" checksum="F8F8ED0CACD6A348" modified="2019-07-31" version="1">MIGYIFTYLIIFYTEIYICTSEYKNKRCVLLSYDDIVNGLDVTDSNTEVAEKSGFRGNKTILKIVTGCALLIKSKRFKSKGCKEKMCSVIPIEKFRKTSFFKKFSTRRVQRCSSDTLYCSKRSTSIESKEKQNFNYFSGERRFYQQDNFISEIEIKVSSDIILSENYKIEFGKIIFIFKTFDKVDDSEKILVLNRNKKIFVPFKEFEVLIIYDRFCLINNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH3</accession>
    <name>A0A4Q9LWH3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0284p0010</name>
        <name evidence="3" type="ORF">CWI38_0917p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000284">
        <property type="protein sequence ID" value="TBU03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000917">
        <property type="protein sequence ID" value="TBU12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWH3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0284p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0917p0010"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="160" mass="19371" checksum="B0AA57B83C6DB138" modified="2019-07-31" version="1">MEFYDLNLILAEETKVTVKFNHDVDFFGFYFAENLSYIPKNHSVKVPFFMVDFLLENEHCILVDDFVEENTKNNLMAKPSLVNLSENYFNFYYFGIIISKYLNIKDFLFEVFCERTSDFCNELFTDKLTDDNYLLMDINEKRIMFFSAFILEKYRRFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWR3</accession>
    <name>A0A4Q9LWR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0504p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000504">
        <property type="protein sequence ID" value="TBU13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWR3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0504p0030"/>
    <dbReference type="OrthoDB" id="8068376at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="486" mass="56013" checksum="18DCE8887DCD482D" modified="2019-07-31" version="1">MSGKDSNTMDDATSPKRAKRLTKYSTTWETSHPWSKEVKNNTFKAFCTICNKELSYAHGEISDKKHHAYSASHIYIIKTRSSSALSKFINKPNDTVLEFKISVSLEEITCVYHTVKHGLSSNSMDCGHKLLPTVCSDSKIAQKFSCGRTKATAIVSELAKESINEVLKSLKEKIHPFPLPMILAIRKTEKCFQLVFVILALILELKIAFWTFLMSAFSADNTNVNFGCNHSIYTKFKELNNSIIKAGCPVHIIHNASNFATNKLKVDSLEMQWEEIVKHVVTRFLTLGPAIERILKLWPALKSHFQDEDNECPTSLQNIFISEEEENKILAYFAFLHNVMFSLENTMKKLESDSLTVVEMHQSTVDLAESMKNDFLSFYSNFIPYLRKRYDFSDDKILSKAELLNIHVDEDVLYEEYQIMKPTFELIAQKRISMLHKNGKRFLNPFQSVSQVYTFKSNDKRRRGRSRKGWIDHKIEKNEERSLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT0</accession>
    <name>A0A4Q9LWT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0889p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000889">
        <property type="protein sequence ID" value="TBU12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0889p0010"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="38"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="234"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="381" mass="43440" checksum="8A82992FA650E090" modified="2019-07-31" version="1" fragment="single">VTTTQFSKWEEFIKNTNLLKGIENMDYKYPSPVQAASIPYSLEGRDLIVRSKNGTGKTAAYTIPILERIDDNKMMPQCIILVPTRELALQTSKMCKKIAKYMKIEIVPIYGGIDLHDDILRLTQGVHVIVGTPGRILDIAERKIINLKLCNILVFDEADKLLSFEFKDSLDKIIKFLPVDRQILLYSATFPSSVCEFVNSYMNKPLHLNLMKELTLKGVHQFYACVEPKNKLFCLKTLLKQLNFDQCIIFCNSIQNVELLTKKTTEMGFPSYFIHSKMMQADRNLVFHNFTEGGCKILVTTDLITRGIDVPTINCVINFDFPKTTESYLHRIGRAGRFGNYGVAINLIGPSQDLRDLENALDISILPVSDKKFQDFMKKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU5</accession>
    <name>A0A4Q9LWU5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0491p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000491">
        <property type="protein sequence ID" value="TBU13243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWU5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0491p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117808" checksum="77BF6BA6F9D1759D" modified="2019-07-31" version="1">MYEDNNKKSLNEKSNNRKNMDENESQEDKKDKCGGECKHDNTKCKECCGKSDSKLNNINENNVVKKVCDDSKDSIGTSKVKKKRTLILTCKEENLVLDSEETNVENESDQSCSKCGKEKTKNKMCCKCMKKVEKRVIRAALSTPKLKKINDDFEISAKKKLYETFVSESSSYEVSEIHSSDSEEWGLDYIEECIEKIKPKKEKIKEKIITKKADVNEDKKFDEDTESFWQHSDTSKIFSSFSEEEEEAEIRSRSKASTDPEISDLLRGENIRDDVFTSSNLSTQNPIYQSKESEENRSFISTEEVDVESFTGKNEKEEESLSNNKTPNIILYGSENLKIQDKKDTESDHDLTSTKENGERLKNEKEVETIKTEKKEEKEEDDAKDDSKNNVKPEEIIFIEENGNGKILGLESDQENENTNVITRNEGFSGIFTSLGLFFAGASIATTAQKNEHHKPSRDTQSSPELLDLLDSDSLAQNSDENNSNNKNIAEEISSSEKSASGANGSDENISTKEVSVSMAEVKKEPGELLKNTNIYENVDGSSLSDATKSSKEMPYGGSTKSKENVKYDPFSTLSSEISENFPVQKGASFSKYHVENPNPTEAFSENEVVKDEKISDAFESKSKPSEDNPVDSREDKIIESNDPNKKVLDDRRTDNKGLTDQSIDKSDISSIKSSRESGHLSLERSDGNQNFSKPEEEKSSNERLDNLNKDQKEIDNKQNSMDNTEKSIESSSEKQNGKKIETEPKEELKMKLTETSSNSLSTQSRFSSKTSSTEEKDEKSERKPMQEIKKLPEERLNSFKPKEQLKPDERKSKEHIKLDENKPKEARERKSIEEDKEIIQPLTSDQKQSEYANKPTKDINKVDKNEDSNGERKPSDVVSEGQESRKSEPKIGKIQEIQKLEFQAELEKVSEIKTASKIISKNEENVSEKTTSDSIVVNEKEEPTEKFVVTHYNLKSGDKNENQNKKQTLASDLTQDQEELQRLETSMNNPIFIYFDTIRTDSATNSRKLRTKGKGRVARLVEYFENIKNLKKDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWU8</accession>
    <name>A0A4Q9LWU8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="12">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CWI38_0852p0020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000852">
        <property type="protein sequence ID" value="TBU12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LWU8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0852p0020"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="16">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="342"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1126"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="438"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="889"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1295" mass="148244" checksum="EF13E6358F721C97" modified="2019-07-31" version="1">MKHLTLLKKLFEEHNTPFPTPTELSTINQPTLATLLCDTTHTNNHPPHKSSSHTISTILKEIKTEIKLAENTTNIRTALSVNYSILIKSHILKTQKAILLLHSSTLSFYRKISGLCVREAKRAFSRTSRVNPLLKGKKLTKEISLYHRKTDKTEKDSKKKIEKEQIEKKKKDFEQKESERQSRKLNFLLTQTELFSHFIMHKKKEGFVYEKDSKEGGVSDSKDRLEGVNDSTDKQDPLSKITDEQHPFINSINEQHPFINSTDKQHPLSTNGITTTIEQHPFNNTPTDIPVIDTKSLADKEIARTQEYSSTSKKSLYTSLQQPNILTCKLKDYQLKGLNWLANLYDQGINGILADDMGLGKTVQAISFLAYLYETENITGPFLIVTPASTLHNWLQEFEKFLPSFKIVPYWGSILERKALRKNWYKSGIGITAGGVNNIKSGEGVSNSNKNNKGSKGSKGVNNSTNEQHPLSNSADKQHPVNDSSNTYHPFNNSSNTHYPFNDSTDKQHPFNDSSNTYHPLSKSTDKQHPFNNSSNTYHPLSNTNTNLHTNTFNCVVTSYQIIVTDEKYFNKVKWNYMILDEAQAIKSSTSLRWKVLLNIKCRNRLLLTGTPIQNSMQELWALLHFIMPTLFDSHDEFNDWFSKEIESSAESKKVVSKAHLQRLHLILQPFMLRREKKDVKDELGIKTEKDVFCRLSYRQRMLYYGIEDSFKSKGVLSKVYSKGVLEGRFNTEDNVGDLGGVEGGVNDRDSKLDSIKGVGVKDSGIKGVNNSTYEQEGVNNSTNTLHPVTSNLDVSLFGLNTEYDNKDLDCLMNMAMQLRKVCNHPNLFEKPEVKSGFNFNKCYFIGRPYVDKGVSRIEMCLPRIVREFVEEKRRGCYSQENKTFSISYMDNTSDTSHNNTPNTRRNNNTSDISHMDNTPSTTHNNTPNTRLIDNTPNACLKNNTSNTSLNNNTPYTLLDNPTSVKRVKSSIINKEEDLKYFCKNKGYFDIRWPMKTTKDLYKSKYKDFNFIFPKVFNSNITSNFNTVNSYKEKDLLSSISKCKGVLNNNSYNNTLLDEILFNNTPLNNNTYTNTLLDNILYPNTPLYNTPYNNTPSSSLTPSLYKEYVTVPKLDTFISDSGKLWVLDGMLSKLKGEGHRVLLYFQMTKMIDLMEEYLIKKGYTYLRLDGSCKIRDRRDMVREWQSKDIFIFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKDVTVYRLITEGTIEERIMERAMKKGEIQRMVIQGGEFQGKYLYIKDRVREALGIIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWW3</accession>
    <name>A0A4Q9LWW3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0510p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000510">
        <property type="protein sequence ID" value="TBU13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWW3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0510p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10042" checksum="AE8E09C55114B6DD" modified="2019-07-31" version="1">MKCKSTNTYSIQSIILKKTVEIIFFSKVEKKFIETNTRESLNIPTNTSCKARLLNTRNILPHKFNGVTTMEKPTINQNEASDFEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX31</accession>
    <name>A0A4Q9LX31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0491p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000491">
        <property type="protein sequence ID" value="TBU13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0491p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="7705" checksum="5F74FD410DC8FD87" modified="2019-07-31" version="1">MSKFDMVCCLVYAHPPGASDRPTGKSELFGSLFGLGAAKVADPFYNPYRAGYRRGVGYGYGTGAAVGGVGYGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX89</accession>
    <name>A0A4Q9LX89_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0744p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000744">
        <property type="protein sequence ID" value="TBU12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LX89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0744p0010"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="654"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="827"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="656"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="838"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="862"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="894"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1287" mass="145633" checksum="07FBB23967CA9490" modified="2019-07-31" version="1">MGLLRNQKALPYKKILKVKNDLKVVGITQFIEIYHLCRNRFHNTFVWGDEIEVMLVAKETYDKMDMSNDYNTSSKESSKESSKESSKESSKESSKESSKESSKESSKENSKESSKNNIYRNEESIKNNIYRNEAINNIKESTKEIYTIPTNINTHYKLLLAAEHFTKNLKSKTALFTPEFASYMVESTPIKPYTSKVSSLLEMEINMLERINCIKKEIKRLKIEGFPLLMTVFPNIGYGKAFYGQMGGEYEDMYEERIDRGIDGGIDRGIDRGIDKGIDRGIDRGIDSSNEIDSSNEIDSSNDSNITDSNNQHTTDIADLRQQFLLRGRFLKYKITRSYFFPDNAITNHFRFFSFVKNIRKRRNKQIEGYISIMRDRNTDMTTVVGKIGEGVIYRREVGGIEGINTKDLMEGVNDKDSNLEGVNNRDSNLEGVNDKDSNLEGVNDKDSNLEGVNDKDSNLEGVNDRNSNYNPVNDREYSLEGVNTSTNKQHPFSNTPNKYRSNTQNTNSNTRRVNGILIDSMGQGMGCCCLQVTLQASELEEARLIYDQLAVMCPLLLRLTRATPIAQGRLLNTETRWDMLVYSVDCRTDSERGSPYERSGFDGCECGMCNRGVNYKSIGVGGVNESGSNIKGVNTSGSNIKGVNDKGIGVGGVNESDSNIKGVNDSGSNIKGLNTSTNKQQGDNTSTDKQQGLNNSTNKHPLNTSTNKHPLNNTTNTQHPINNTTNTQHPPNNPSNTLHPPPTTTQRIFKSRFSSIDMFISQSELNLKEYNDIKVPLNIECYNLLINNKVDILMSKHISSLFIRDPILVYEDSISRIEEMKKRMECSSRDIKRDNTSGDNLDISNNLDISNTSGDISNNLDISNTSDNLDISNTSDNSTTSDTSNTSDNSNNGTKDISNPYTSNPYTSNPYTSNNIPTNSYTSNNIPTNSYISNNPSNNNHLNNNNHLNNPVPCLDEFENIQSSNWRSMRFKLPDITGGDMSGWKVEIRPMELQPTCFENSAFCVFVVLLSRAVISYQLNLYLPISFVDENFRRANLLGRRVEEYECSGGCSSGCSSRDNGRDMFRDNSRDMFKGSGSSRDSSRDSSNTREIKKEIKKEINEEINKEIDKEIDTNQPNSQLKIKVENQLKIKVENQIKNKVEIEPNNQLNNIICHSLDLSVDSLKFYYRRNIYEKGICKIEEGNLKEIFCGVGEYPGILNVVCKFVREHCGDNQGINKYLEFIRKKVCGEVMSVSEWIRGFVVNHRKYCRDSVVGEEIVNELVEEFKKIEEVNDYEYLRVNSRGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA2</accession>
    <name>A0A4Q9LXA2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0439p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000439">
        <property type="protein sequence ID" value="TBU13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0439p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="26039" checksum="748F2411E0E562CA" modified="2019-07-31" version="1">MKIFSKNVLILIFIKFDSIKAVLRIYFINDQVGMEPPKKREKMDIKENTDLDFFEIEERDTNFLTFNKISIKTQSDILYLSFDFHKDKIFNSILKMNFKILVDEFFKIWSFEKCFYDSFIEVEDLKNDDQEDVLCDVIERIYTLNIDGNEYSSFGWKIKNDHDFIQQLHIIFRICKIHKVNIFDYTILHEPIADILSRIAESIEKIDFFTTLYLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA5</accession>
    <name>A0A4Q9LXA5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0468p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000468">
        <property type="protein sequence ID" value="TBU13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0468p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="182" mass="22021" checksum="B1A33A4293AB5D11" modified="2019-07-31" version="1">MIWFSIAKSKDLENLDIKKVSFHFRKQEIFSHEFYQILSKEYFGRIIPQIKKNYIVCPKEKLFKYPKEKIIPYFEKQFRETLNLYYNLFIVNFIGKTVEVFINLDLKYKLWEIECLIGYNIDFDNCSITFKELDLKLFTTKNITKENKIGKIVIRNSKVYSDFLKDIFAINELKIFNVMTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ0</accession>
    <name>A0A4Q9LXJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0532p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000532">
        <property type="protein sequence ID" value="TBU13096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0532p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="8804" checksum="D7D0FB6AA84A6DEA" modified="2019-07-31" version="1">MVYVSKGCYVLGYSMVKSVITIDRLDGSMVKSVITIDRLDGSMVKSVIDNVHRYRGVIDMYLLVKGVSYKGRGVNYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN3</accession>
    <name>A0A4Q9LXN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0394p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000394">
        <property type="protein sequence ID" value="TBU13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0394p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31714" checksum="DB11C700729EEC1C" modified="2019-07-31" version="1">MILIDYIRDHLYIPTYILILTVFCYIQDRNVFWGADGMCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYNFKSLKRIRSHSVQKILDNKYAELRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVITNKSWELGLIYMCNGIVTKYHKSHLKRLEIPMNVEAYIQSILLKKTVETISFDRRRGLDWERALMGVIMRSEMHEEPIPPLKEAKTEEDGAKNLQPKNKAPLISQGGTTLEEPTNNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY59</accession>
    <name>A0A4Q9LY59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0605p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000605">
        <property type="protein sequence ID" value="TBU12851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0605p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24588" checksum="120CE3C98C397ABB" modified="2019-07-31" version="1">MNKYENKFLIMMGYSLKSLVILIFAFEIKCGKSKMQGYLDENGEEWTENKDIVLTNKVPKTSESSGLDKSGYIFDSERYYDARGDLSDEEYYSLSANSESFKGNREFLDDKNEPAVLLGKTPINESTEPNDKQAIIVNDTSKPFGLIKNSSLSLITRGKKYKFFENKFNMIRDKLIRRRESKKSETLIGNSPSQSNFPLKRDENFNRMKEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYD0</accession>
    <name>A0A4Q9LYD0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0317p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000317">
        <property type="protein sequence ID" value="TBU15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYD0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0317p0040"/>
    <dbReference type="OrthoDB" id="2195945at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="50779" checksum="36D8A4A0F7A80120" modified="2019-07-31" version="1">MKIEIPLIDIFGNYNGKILGTIFSFRSGISNEMSRSNIDTNENTMWIVLINSAQYQPQDVLNKFLISNISAIIITDTRNHVDVVMEYRRYKSNVPVFFMEYPYFRLITNFLQRNINFKRNQSLGRNKKLNDHTILNKVLSTTTMHNRREKLDYNVKEHNKGNKKILNPNSVEINSQIFFEKSEPYSFIDFKAGEKIFKPEKEELEGTQIPTQENDYLNLSNKNNNFRKFNNLYFTKNQDIDILKGIHKNSFIERENKKYRNTCDTVAANTLIRANNFVLAENKVNLNNNDTRISRQPEIVFETAIENKHDFNPTPFFVQLFLQIPPVLTILILVLLWRTFSVPEDQSMDIQYIETLPLITYKHENIKNISFNDNTICCICLEPYIQGDQIRCLYCHHIFHKICVDPWLCRTCICPICRKSIFLTESDPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI1</accession>
    <name>A0A4Q9LYI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit Rpn7 of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0630p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000630">
        <property type="protein sequence ID" value="TBU12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0630p0010"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="179"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="655" mass="76774" checksum="78796777A36C29AC" modified="2019-07-31" version="1">MDCNFNKPDLYFYELIKKAKTNPEFTKELKNKIIENEMTFLYLELSTKKVIGYDESEYGILRRANEAQLKKFQEEKESDPDNETFQINVDKKIAEYYAKTMDIINLNSMFRDLRKKVFSASFSVDVLLCKMRICFILKDKRSLPIIVNQLNSITEKGCDWDRKNKFKSYEALYLLISKDFKKSAILFTECLATFESYELLTYEKAVLYAVFTGILTFNREDIDKKILQSSEVMEAINKFPFAYKLVESFYKCNYRTIFYEISDFAENIRNETFLSSLINYFVYEMKSRVYQQLLLSYKSLHIETMASIFGVSVEYLEKDLIKYIVDKKVSCRIDRITMSVSACKSEIDYNSYVVESSDEMLRMMRKILVSVSDSSRWLKRGNIRPRNEAVFCYIKDRNVFWGADGMCQYCGKSGKTVDHLATRFEKMLGHDYTRQHNEVVRCLHLLLQIDISLIQEILDNEYAAIRVDTKIKTDVKIRNNRPDIVILDKKKNKITLIEYDLLANELGLIYKCHVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRQRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREEDGAKNFKPKNNTPLISQGGTTLEEPTNNINKESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ0</accession>
    <name>A0A4Q9LYJ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0628p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000628">
        <property type="protein sequence ID" value="TBU12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0628p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="273" mass="32871" checksum="6225A3BA5F7657DA" modified="2019-07-31" version="1">MYKALACFSRARDNTRDSYIRIGDVSHGKHTNIPRRFQIFHLNPHYDLFHNGFCVRMHSEIEIFEENTINKNLMIDKFNNLFGETMCIYSGSYSYYIVYNEKYETYNNKISKKSYKLNLKIHSINLRHELQILKPIYYFYMQSRVSFILKNIKIEYSYFNEYEKFSAQSRKFRIVFKHSKSIFEFNSNFLGCIVKRYIPAASTYICILRETYFDIIDLEYEANSNNFKISQIKKYNVFQTSSPVEFSPSFYAQEVLSIKDFLDMLFFNLEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR9</accession>
    <name>A0A4Q9LYR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0582p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000582">
        <property type="protein sequence ID" value="TBU12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0582p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="48083" checksum="A93317B201290402" modified="2019-07-31" version="1">MKINIFYEFENLKHEFLVPVFKEVSSTFYSLNEIYLQSGEELSFHKYKNSSQNINILVTTSLEQYLSINEYKIFIRQEDEEECKKMRDKAEDSVEEDNKITANEVEEISVHKNNILSQYINEINFISSDYKNYKQILSDFVLSCIKIQQIDLSNIYVKNKEGIKMNPEFHIYVEKKPFIKLENKLAHLSNLKQTKDNKRFEYSMINENFLICKILDPILKSLLKFYDLKFIDSNQITYDLTYQLNEYFIVPSSNHSIFSSLICQNLYKFDELNLFIKYCDSSKSKYSHQIKTAFCCKLMDLEINAKFNRTLKAIERKGNLDDFNLVLNTLEILPNFFDHRKVFYEKLKNLFEILNKKYSKLFYDDKLINKSQLKTEYLPLGQYRNIDRQPVMSLKRFYYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS0</accession>
    <name>A0A4Q9LYS0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0280p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000280">
        <property type="protein sequence ID" value="TBU17624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0280p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020640322" evidence="1">
        <location>
            <begin position="28"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="53553" checksum="CB6E563DB28A1CD2" modified="2019-07-31" version="1">MFILHIKNHSNVIMWFVLVFSINLTEFSSKLDNLCEKRYKYSENILQTFADTDYFEILLETLNLEMDVNESISNYIRRSESQMFKIFIDTRNNEELNTNILDKIECFYLKKCSLEVYIFSVNYFKFIDDGNTTYIRKIFLYDKLLSVLIAKLFIFSKIFRIFSVCFSDFNYTYFRFMIYDVKFSSEYVLNLPDKFLEFVTDTYAFSITASIFYTRIILSSKCYKNLNNLDNKTFYEEQIDYFNGIILKYQIEFYWRYEYALNHDQNSYSFKIRKNYSLKIVSLEISKSLKNDKINIKTYISIQDRFFSYENIFFYDLAKTRYKTLILSNDYRDNSEYIYFEYYFIGYDFRTKTAKYIFKSIFFEKKDKIILYVDENLKIVNILQYKDINNAYATINLENECIENIIANLFKWLIVKLFLPNLNFTQQIFINMLYENIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYS1</accession>
    <name>A0A4Q9LYS1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0037p0060</name>
        <name evidence="7" type="ORF">CWI38_0536p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01000037">
        <property type="protein sequence ID" value="TBU05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000536">
        <property type="protein sequence ID" value="TBU13081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0037p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0536p0010"/>
    <dbReference type="OrthoDB" id="2189070at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="118" mass="13709" checksum="28B9F12A92471994" modified="2019-07-31" version="1">MRQKFRYVAAKFTFNIQKTFIFSQEVLFLLIKDLLYQNFGEIGVAKLDTFILIEYLPANNICIFRVPLYVSKEVIYSLITCGSIDSLKCNISIFFISGGLRTLKKRIIKFVGDDKNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ54</accession>
    <name>A0A4Q9LZ54_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0552p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000552">
        <property type="protein sequence ID" value="TBU13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0552p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="52691" checksum="B97B0C5664103442" modified="2019-07-31" version="1">MQKKMDVINIESEKKNSASSIKDLWCPLVYILLYIYLSKNVLTHLGNIRISYKSILEHLYFCVSSFIFMIGIITLLSIIGTKIPKKLVIFSFFSFSVISVPFLCFIFKDKQKFIQNSTIYVITCAGIFVFFLVVSILMFLFYFRNKIAYNIVLIDSVRDFLRSEIFDIFMAFTFLYFKSYLFISLSRGIQNLNPEDNIFNSFLTYFLGCWAFLVIVKGTRAFLSFSMYNKITGTTRSRTVKDTIYILGTVYLAALIFPFIFIFKRIKRPRIRESDSKIIYFLKSIYDFPLSVIHFFIKDAIVYDNPLIMIYAAVNNLPYFDAMYDSYKLYIHSNTKRLCDDIKIYECFMPFILLLSATTTYFFNEHQIFKKYTFESSLPIISLFMLCFLELIYTSSQFLVYFYVIKPEELRNMNPELFNIYDRSLTDKRYFNLQESEKYNILSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZB4</accession>
    <name>A0A4Q9LZB4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0225p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000225">
        <property type="protein sequence ID" value="TBU18880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZB4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0225p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="111" mass="12863" checksum="D5802F4A5626BE03" modified="2019-07-31" version="1">MIFGTNQLKDGKHIESNESLRPQEIIFYYDLPAGIGLDDITVDFDDHNFKVTYSKEVESEDKSSFKTIEGGFSEHVSFKLEKGQHWIKNNKLWVSFENGDEKKMSTIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW5</accession>
    <name>A0A4Q9LZW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0179p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000179">
        <property type="protein sequence ID" value="TBU19894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0179p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="13919" checksum="6311A0BB43F8602D" modified="2019-07-31" version="1">MCADIRTQNFILDISKKKIKHIELLITSRDSLKTYVLCANKLVLIYMHNVEIVSYVMAWDGSKRNAEESLKSSEMEVIEISEMLLKIKKSITPHISEEGSTLDEPTIQINKESDLEGETFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW8</accession>
    <name>A0A4Q9LZW8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0312p0050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="PITK01000312">
        <property type="protein sequence ID" value="TBU15422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LZW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0312p0050"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="11">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="571"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="9">
        <location>
            <begin position="927"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="10">
        <location>
            <begin position="1376"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU15422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1462" mass="164445" checksum="4DA935CB2DC83CA0" modified="2019-07-31" version="1">MQKDYKKLKSLFYPHISSYNTFISTLPSIISQLPPLQLTYNTTQIHLKFTSFKLHKPHLSDTEYLHSGIKLFPYECTHRNITYKGRITIEYTLTYNNTTRTHQLECGNLPIMIGSVLCNTTGNKIDTKGNKLDTKGIKGSKIDNKSNTNNTNTISNTNNNKNNSIFVSPGGYFIINGHQKVVRLLIAPKRNYWFAYTKPTHKKKSPLFTPFSVTTRTVYNEIGHTLTLHYQRDGGVTARFYFNRNEIRIPVIILLRALTSYTDKDMYTFICTGNKGGDIEGVGGDSDIEGVGGVNDKDSNYRGVNNNTNYHPVNNNTNYHPVNNNTHHPFINNTFTKLVNQFLLSDTCYSTDVCKEVLERDTRIPFKTLISIICTHVESVIHKEYFLLLGIRKLFMLVSGSLESEDPDCYANHEVLGVSNMLCSLVREKLEEMLRGVSYMVSKIGGKSSNSRDILEGVKNSKEVEGVSDSRDILEGVSNSTSKQHPVSNSTSIQHPVNISTSKQHPVKNTPNNTNPYAKTLGGKSIDEVLRWVLNKVDTNIGLKIEKFLSTGNAKFVYASDIMQSSGFSVYAENINFMRYLSYFRSINRGAFFSTLKTTTVRKLKAESWGFMCPVHTPDGSPCGLIMHLCMECRIGETESLSDSVLYGMGVIPIECLLGDNDSKEVGGDKDMMIEGVSDKGSNIKGVSNNIDNIKGVSDTTNTLHPVNNLSNKQHPVNTNLNKQHPSKPNNLYNTPYFISLDGKVIGYTLTPFKLTDTLRTYRCLNNLSFEIVCYPLNTNNLINICTTPNRFIRPIYNKIIGKPEFIGIMEQPYLDIELCRNDYIDKEEGVSNSIDDYRGVIDMDSKQQGLSNMDNKQQGLSNTTNNYNTVNNNTYKQQGLSNTSYNYNPVNNTTITTPNYNPITSTSNNTFLYSELDPSYFLSLTAALTPFSDFNQSPRNMYQCQMAKQSMGWGCYNINDRSDSKLYEITYNQTPIVQTKFYKKYILSDYPTGVNCMVSVLSYTGYDMEDAMVLNKGSIERGLFNGFIYKNEIIEFDNIIRESSRDSRLDGSRDGKSDNNNNSVNNCCSSVKLPLVGQVLYYGCEYYFTDKQYFYKNTEKSIVSNIRVYSKGAVITLRIQRNPYIGDKFCSRHGQKGVCSYLYESSDMVFMENGECPDLIINPHAFPSRMSIGMFIESLSGKSGCLRGKIEDGTAFKGWSDIVCGSDMLGSDVLGGDMLEGVSDKDSSLEGLNNSIDKQQGLNNSTSSYKGVNNSLYKQRGVNKSTNNYKGVNNSTNNYKGVNNCANTYHPTNHTTNTSAIDFFGNLLVKYGYNYYGTECMYSGISGRMFKSDVYTGVVYYQRLRHMVSDKYQVRSIGPVQSQTRQPVGGRKRMGGIRLGEMERDALIGHGVSYLLNDRSMKCSDGTEFLWCCVCKSVMFVCGGVCECGSGSYRGVKMPYVFKYLCSELMAMNIRVKIEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M083</accession>
    <name>A0A4Q9M083_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0156p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000156">
        <property type="protein sequence ID" value="TBU19999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M083"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0156p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="14079" checksum="A4AEC0235F99E4FE" modified="2019-07-31" version="1">MYMNYGDFVIFKWVKATRKNSEYHISPKSKNLNDNISLFIGFHCARSLHFMFQIPPIYVIMRAKMQEEPKSPLNQAIREKMEPTININEESDLEEETTVVKLVEENALKLKHFNPDFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0E7</accession>
    <name>A0A4Q9M0E7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0400p0010</name>
        <name evidence="1" type="ORF">CWI38_0830p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000830">
        <property type="protein sequence ID" value="TBU12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000400">
        <property type="protein sequence ID" value="TBU13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0E7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0400p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0830p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12713" checksum="332658E18E99E67C" modified="2019-07-31" version="1">MGSRKREKTTLLNFLAGKLLSDFKTKVQVLVNVKTRNQETWYKNLGYIDKDIFTHDDLTLKNLSYLTNLFYFQILLQYIPVKLKKQNNVLYRMGLKRNLLIFLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G5</accession>
    <name>A0A4Q9M0G5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0230p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000230">
        <property type="protein sequence ID" value="TBU18740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0G5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0230p0040"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="80"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="532" mass="61833" checksum="B3A330DF3C5535B9" modified="2019-07-31" version="1">MKEKLKTSQNEHNKDKLDYFDENEENKIINVRKKALNIKTKLEKISSVEVEGATQVVEKFEQKLRIEWPVLFGENPKFIFVYVDLDSFYASVEMLKNKSLHNVPLAVGGNAMICACNYKAREYKVKAGMPGYIAKNLCPTLLIIKPNMEKYNYYSEIIMGILSKYDKNLEMYGIDEACLSFDKDSFNTAYNILSKKTDLKKKIDFENSCVLFTFENICKIVEEIRNCIFDTTGLTISAGISVCRGLAKLSSKVNKPNGQFCLKNNFQTYLNDLDVDELNGIGKRTKELLFRTFNLKKVKELQENIHLLYLSLKMKTFNMLFRLSYGLSIFDGLRPVSYTSLSKKSINKEYSFKATNDYIEIMNNIYNISKYVSKKMQKNNYLSFLISVKIKFSDFNSFTIQRQCKVPIKTIEDIFDTVIDLLTNHFSDKSIKQKLYESICNVNTIRLIGIKVSSLIKEMNFNLIQKYTNDMVICSERLCPICNLGFFNESNFIFESHVNICLDKQQTEKRNINRTLLKFFKSRNTEPNEKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J4</accession>
    <name>A0A4Q9M0J4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0128p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14863" checksum="58B9A65DCEEC4896" modified="2019-07-31" version="1">MNSNVLAEKISVSLRKWTVMKLVKNYIKEESVLDVEKVLLQFFLSLNSKKFKKNEVTEDIAEYLNDFLCKNNVDTEYSSCFNMAVCLVEIYTENIEGKSIIYNEIRSKNEAECENIETSDDSFSESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0L9</accession>
    <name>A0A4Q9M0L9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0392p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000392">
        <property type="protein sequence ID" value="TBU13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0L9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0L9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0392p0030"/>
    <dbReference type="OrthoDB" id="2192720at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="103522" checksum="B8D9F475B5D216DA" modified="2019-07-31" version="1">MKQRYSIVQLSETNKPKTQIYTSKDCVTLGRALNNDLRVQQNGIENKHLEMNLKNKTLLAYGSDVKINDFPVSTNTITSFNFNDKISIKDTHFSVQIDETNDDGVGDKSTLSNLVDTPFFSPSPLKFNPSPQKPRRSVEPHPSVLTPSYDQSTTTSDYNLYLQPPVRNVKQTSSDFLDVSQPKLNHEESFLAQTEDGLSSEIKNDLNKEIGILESPVERMVDGLSSEIKNDLNKEIGILESPLEKTVDEFLEKKEIILENIPTKSEILDSNLDSKNEKNVSKIPGIFSKSDELNILNNAINEENSDGIVTIKRETVTETINNGTKEVTKEVIEEIVETETKTFFGLEEAIDREAKRVDEEIKSNVEKITEGSVNIPVSPEMVKHPHIDLHAAVLEKNILKNAKDVLEEEVRDKVEIERSLKDRESMESNKIFQLQPSIEILESESLEGSNLITKRLSDGDEKIPDLRIKRIKKEEGDEILEEDDSKITKDIITEPIIEEIPMKNDVEEVEKELEYKEEGPKSTLEVFEEKEGELKNKSEESEQEKNKIETQESNVEKPEVKRKRGRKPKERKPEDEVIKVKGKRGRKPKNKEEKKIEEEGVIKTKGKRGRKPKNHNKVENKEENKEGEIIKKKGKRGRKPKGEKKAENLDDKKIENEGKSTENNIPNLEEILKKKDISIENAISPRKRGRPSHKKDSSGEKHKESEKNEESKFKKEETKDKNFYELEEKKYSSKESEGNDLIKEKEQRKSSKNNSKESEEKDLIKEKEQRKSSKNNSKESEEKDFIKEKEQRKSSKNDKSSKKNRHGKHKSSKEEETSKSKTSSTESSSLTRKPRRSSFNSSTETNKNIKKSEVNKLNSKKYEKSDKKQQRETSSEDKNKIKKKRKSAAVSNTPTSSSKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0N4</accession>
    <name>A0A4Q9M0N4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0374p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000374">
        <property type="protein sequence ID" value="TBU13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0N4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0374p0030"/>
    <dbReference type="OrthoDB" id="2233964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="65292" checksum="450C2C696BE5DFCD" modified="2019-07-31" version="1" fragment="single">MEKEIGDLLVRTRKLLSELVTDEETSKKRPRSIWKENIEIKIYVLKLAKYILKEAHRQEKLSSLKQKVSLEFSHTNDLSESLNGHEKNLTMYGICRFISWLPNWKSAGIDGIYNFFIKKLTTLHKYFYDIVKVICLERTPQADWFYSGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGYLAENQLGAVRDVQGAKEQALPNIALNKEYGNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPQKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTEVTLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTAILLDGIIERLCHTRLNPKNIFSAINQHAISLINYHIGNKINLRPECKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCHHCGKSGKTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P3</accession>
    <name>A0A4Q9M0P3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0214p0100</name>
        <name evidence="1" type="ORF">CWI38_0220p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="21393" checksum="A5073608698F4CF7" modified="2019-07-31" version="1">MVVAESVPNSTDIVTFENEASGQGGAWCNRTLVCKNRIEYNIKMNACQSKELHEKESNNDCRIGIPETTKAELSPQKTESLTFSCNIIAEDVISINPFQKTNHINMLSHQRPSIAPNSNTERKISSDNCHASCGENKICDESCNRYWCEACKLIKCCEDPDFVSGCTEGFCISIRIFLEVIFNTLDVVVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0T4</accession>
    <name>A0A4Q9M0T4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0100p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000100">
        <property type="protein sequence ID" value="TBU20264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0T4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0100p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1066" mass="123231" checksum="B0C6E94C516C20D7" modified="2019-07-31" version="1">MGRKKNFRNEKSKNTKIKAVNDADELHPLAIFQPSSSYTKITHPPQPNMHELDTLPSAKPPLPSSVEVSACEPSYEMTNPCNRLMALRTIFDSVRPDPNEWPRILHMYYNEKFGCTETLEVLKKLAQSEMGKELKSEENGERRRIAICLADTCTLTDTTEYINLRDKFLSKIKEISMNEIGKVVVRTRKHPNELVDSKVLDLINREVYEYAGAHVPESITEAAYIMQASQVCYDEATRKEKPRFAWKENIESRISELVLLKNLLEKARKQEKLYTSEAKSLKKTMREFNLNLSSVTDLSVALVKKNMSLNVYEKKITMYESRKQFRKENRMFELFRGRFYRGLSEFVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYIYDIVKVIVLEETPQADWFYYGLTYLISKGSPQRGSDYRPIPCMSNLYKLTTKCVTKVVQLEGAKEQALLNRSLIKEYGNNLKATWIDVIISKWKIDISVGPEKIMSKKIERGILQGDSFSKLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHRLFIDYIKLLAKDSFTLNAMTGEAKEFLEVIGLEINKEKLATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEESQRLCHTRLNAKNLFSAINRHAISFINYHIRLDDAVRAVSVKIKIHLRSGCKERLYLPRAELGRDLNKISTRGAAILNVEKNSKTHLAPIEGFLKVKYKLFRKAQLAKLYNEIEKRELHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQYRNVFWGADGVCQHCGKSGKTVDHLATRCKKMLGHDYTRLHNEVFKSLKRIRSHSVQEILDNEYSEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVAITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRPEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGTNTPLKEAKREEDGGTTLEEPTTNNINEKSNLEEETEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Y7</accession>
    <name>A0A4Q9M0Y7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0090p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000090">
        <property type="protein sequence ID" value="TBU20320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Y7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0090p0060"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="23314" checksum="06E5D4F1234D2CCB" modified="2019-07-31" version="1">MLGHDYTRRHNEVARCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNIPDIFILDKKKNKITLIEARITLQDSLQIVETEKLKKYDLLANELGLIYKCSVEIIPNVMTWDDIAYIQSIVLKKTVETISFDRRRGLDASLGFILGAEMHQEPTPPLKEEKRAEDDAKNFKPKNKAPLISQGGTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Z6</accession>
    <name>A0A4Q9M0Z6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0088p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Z6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="32924" checksum="7BEEAC1054CA5A6E" modified="2019-07-31" version="1">MLSENIKPPRDHNLPRFLTISRSRQSRWYKSWYIKTKKFFFQHLFFVVYVMIDLMIVCTLEIIYKEYIQVRILFFVALVHVYQRVYFPAIDFHFYSHLIPKDRYMLILRIGMLFTYFIQSLSRFSTENEFLINLRIYNRLYAAILGNLWSLSSFLIFYFTMKFFPNFLIEFRNSQKILIAALIALIFFFLVHQYELTYLLANIFVNFDFMALLPSYIIVGLIIYIDPEISDENHNTLYDIFYSLIYASMQWPFLVNILKNIYSNLIFRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1I2</accession>
    <name>A0A4Q9M1I2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0049p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1I2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="795" mass="94080" checksum="FB64C7ADF20BE6D8" modified="2019-07-31" version="1">MYFKSRKLRTLTEKNRQRIFRGLIIYICSIYSTTVSFFVINHESCIFDFIANDSILETSEQQNNSVNSIHAEEKITFLKNDIIRVESYNTNPKFYNSYIVTIPYKDSMLLNSKYIKDLFVSNAKNIRICLKNVSYTGLLLFFKLIDNPDVSINQMKIQDFLEILMFLTILDIQKSKERDGFLKEILRNIIFSMANINSNFDYKKYSENCGYESIKKCIFRDLFIFFIDTVTFKSRRTQNFMVFSEIADLSINSPYIYFSSKEIPKNNSNSKFYLRFEANDIENISKIIEQEYLINTWIFLNEIANIDILYLIFNEKSAYKKAIILFSNVTFHAENLYIYSYENPIKLFMNKNVTPFSKKLKVLKLKCNFTTEEIRKLLNVCKTIRGITLKTIILDFEILGLLIDFFIKNPDKHCKVFCTTYIFLGTTIQFIRKLPNNLSLHAINFQKGSDIVNISLEYMPFFQTDKYCYIHTNNSIIPNNFVFLELSNFKNLTLNYKHCSSPYKLDCNVFTPLKYLKTVKYFTLQNIVICDELLLYFLESNTIVLFRVIDFVCNYSLKFLENNDTYNRKLESINFINSLSYFDFGIMIYLSRFQRVVGLKLIDISINSLKIYLKSIFNNILGSKFKLIHQIYLLILKITTKSSTKEKCNIFELISETYEISDLVQIEYCVYEITETDYYFFSKMKNLKFISIYVRNRSKIIEFCRLLYNYEPDITITDLYINVSRIQKNDIKAFKKLKKLSVLSLLCDTIDYETVSIIKKSDFKKTAFIIRAPVRANRSVEINTYLDSEFRNNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J5</accession>
    <name>A0A4Q9M1J5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0284p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000284">
        <property type="protein sequence ID" value="TBU17611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0284p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="78" mass="9446" checksum="9EACAB36AE1E52EC" modified="2019-07-31" version="1">MFIINKMLPPSHLYNIYVDYTLRKRMEDGMFFEDAMDRFDYLVGTDYMESEGIIIQNKERKMEEKGTNFLEPEYAMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J7</accession>
    <name>A0A4Q9M1J7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit beta of nuclear transcription factor Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0292p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000292">
        <property type="protein sequence ID" value="TBU17002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1J7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0292p0020"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU17002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="15884" checksum="AE9F9C85445B2A41" modified="2019-07-31" version="1">MKHNRNNKNEESSEDMDETYLANLKTTDRLLPIANISKIMKNPIPKVAKVAKDAKELMQKSASEFIAVVTCMAKEICESENRKTLTGDDLIRAMEQLGMPYYAELTRKYFVKYKEGIKNGRPRARHNSLIESIDGNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q0</accession>
    <name>A0A4Q9M1Q0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Flap endonuclease 1</fullName>
            <shortName evidence="16">FEN-1</shortName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_0267p0020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="PITK01000267">
        <property type="protein sequence ID" value="TBU17866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1Q0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0267p0020"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU17866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="347" mass="39727" checksum="CA02CEF67037E1BB" modified="2019-07-31" version="1">MGIKQLSQVILKYNKQSIRERSIGYYSGKRIAIDASLCLYQFLIAVRSEGMVLNAADGETTSHLVGLFYRSIRLIENGIKPIFVFDGKPPHMKFEELQKRSEKRIKADEEYVKAVEKGDLGKMEMYDKRKTKVTIKHVEDCKKLLSYMGIPYVNAPSEAEAFCAYLCINKHVDAVGTEDMDALTFATPILLRNLTASESKKLPIKEYNFKGILRDLELTDSEFIDMCILLGCDYCESIKGIGPQKALSLIKKYQNIENILQNETSLEIPDEWKYKDARIIFEELVNLPCEEELPNFKYGAVNKEAIIDFLVVKNGFSEERVKKGLERLILAQKKGKTQRLDDFFKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1R6</accession>
    <name>A0A4Q9M1R6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0046p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1R6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0080"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="792" mass="93386" checksum="6F6F8F67B88DD8B9" modified="2019-07-31" version="1">MRFSRSKSNNIYREEYSDNKIQRIIISFISIVASMSCVTCLKYTYGFERQGNLEIIFLSDRNISDVTLQNFNEGLEFEVFYNIETILSEKVVEVSYRRDRFISFQLINCILDSHTLENSFGKIECNFELFYFLKLTNDISDIPDKVESNTFQSLLMVLKYLKAKEGKNQIKFLQFLIFKTLFCRYNVEYDRTNSDVLEFFNSNFWSQIGFDIMKDTMVAFLNNIMVKYVFQDGNCILLEKANDFYDVSLFDEHIPYKNLMINNCKIFCIIENILRDSNTLIFFEIILDGINMRSLVLNNSIGFDFPDMGFSFFILSIKTFKSVTVSNFARSPSQFFNKISLVLRNEIEFLSFINVVIRKETLDLFLKKQPLKGLSLTITDMEIDTHFIDDYTYSIDALEYINFRILCICPNWWTRFFSTENARIIKLVLYNNLAQECFVNEIVKLRTQQKTLYLDVSFVSFANLNVFCKYLKHFIHLKTLKLYRFKIDAVCEKGFVKSLRKMDALEHLALRHYAFRTKIYNFIFQKQGIKILRLENITQKQEILNIGSIYNHQSLTELFLMNFKIDIEGLAEIFNLLNLKVLSLESCIIEYNIKLKFREFRSKSIESLFLRKSRIGTPENIILLSSLNKLENLDISGTQVLPGYLSRLSQMCNITLKRLLCTFCVLNSSDLNRMKNLEALEELNLAGCEFSGCNFWKFLGGYCNFSNSLVILNLFQIKTNYKELKYLRNFKNMKNLSLSVVGYEMLAEKNYLRFLPIKEFSTAKRFRSANSTEAYKYIYLYEENINIDYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X0</accession>
    <name>A0A4Q9M1X0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0224p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1X0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0020"/>
    <dbReference type="OrthoDB" id="2193331at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="3">
        <location>
            <begin position="434"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="583" mass="63444" checksum="EBAEF5D02FFBE93D" modified="2019-07-31" version="1">MNSNPFGSNSEEEKKKQNAFFQNNQQNSFPFNLQQGFTGKQQTNASSVNPMDVQTQGSVEDKRVSFANPLAQNTYQSPFTQSGGSGSSNPFQSQSSNIFGGSNTGNPFNQTSSPLSQTNLGGSSVTSNAFSGQGSLFSQNSAQTPFGQSSNSAFGSFGQTQPVKSSEIQGGTQSGLTSQFGGSNSFFDQKNSSSAFQPPTNLFGQSGSLGQGGTLGQSGTSLQTSTPFGQSGTSLQTSTSLGQSGTLFGQSSTPFGQSGTSITSLPSNELKTTTQSPFGQSTTVTTPAVQNTSSTLFSQQPEISKPPNDIFSSTQPSFLGSQNISAFGGQPSSFSQVATPPSLFPPTQPSTQSSVFPPTQPATQISTQTSTLTSTPTSNLQSTQPTNQSTQLTNQSTQPTLQSNLQSSQNLDSSFQSQKKEDFSQQSVVTKEIPLFFRQKTVSEVIEELLQTLEKNIKEFHKKAYEIYLYDEKIIKARNNYCKILDTLEREESRILELEENLDFFEKWISDLESNLNLKENTKDELISNIDEIEKLYEDFNKIVSELKDEDDEVMCLINENHNLVKMLDRKVEEFSEFEMSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M212</accession>
    <name>A0A4Q9M212_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0022p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M212"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020703697" evidence="1">
        <location>
            <begin position="27"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="496" mass="55790" checksum="AA5E502FDDB55206" modified="2019-07-31" version="1">MKMTKRIHFVYFSLFMFYGLIAFCSSERPVGCKKRSEEHVSKNISHRTDKDKGYITTGPVNRDYIDQKNETSALTPKISDKTLEENNEASSYALKNHIHTATTSETLPIFKTRIFYNTKFSDRCSPRMISHRTTTFLDTTKQDGLGVTTLRSTDKTMNLYEQKTNKSLTLTPNETKYKEKTTTTRIPNFQVTNRYEFSQVNPVLIGVHQQNIITKYTSDRTSISSYDSWQNNSNPPINSTAVSYQNLSPYYNRPYIPITPKYPPPPQYMIAPSNMSLFSSMPPGCSPPPQYMITSSNMSLFSSMPPGCPPPPQNMVTSSNMSLFSSMPPGCPPPPQNMITSSNMSLFSSMPPGCPPPPQNMITSSNMSLFSSMPPGCPPPPQNMITSSNMSLFSSMPPEGPPPPQNMITPSNMNSFSSMPPRCQLTQQNMIPSLAVSSNPSIPLRYSNYYQSQNLQFILNPPLSQMPPIYSDPQHNIIPPLYINEFNPMPPRYHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2I1</accession>
    <name>A0A4Q9M2I1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phospholipid-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0078p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000078">
        <property type="protein sequence ID" value="TBU20387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2I1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2I1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0078p0030"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="878"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="914"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="10">
        <location>
            <begin position="768"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1012" mass="117988" checksum="F3B7FF6439BFD7AC" modified="2019-07-31" version="1">MKEEKQNRIVTSKYTAYSFIPLNLYMQFTKYNNLFFLVTLILLIIPSISPFTPYTYLIALSIVLGVAMIKDGIEDYNRHQQDNEINEKPVFIIKYDISDEKLKIFQENVEDLKYGDYVVVMENEEIPADIVLLNSLIHSTEQKCKNYCFVQTCNIDGEVNLKKKFSLFEESMKKCTQIIYDSVNFTEREIYPSTCSCMIEMLKKIKSLDINDNRSINSDIECYIKTETDQIMQSEKNILLRGSKLKNTKQIFGIVISVGNKTQLSKSLHQTNIRISIFEMMVNNKLIYMFLFYFIVLTITSILASLFLKKDNIQYLYLSPNLGEESLKLTGTNYILFSYIIPLSLFVMIEISRIFQALYISNDEKLRFNGINSRCRNSNVIEDIGIVEYVLTDKTGTLTKNEMILRKYQIKDFSDFVERNELVSAWEYAKNKEKSIFCKKGCSKITENDLKNNFPLLLIFSILCCNSVERLNEKYEGVSQDEVCILNALEEEKCYITERNENYILLKIGSNTVRCDISMVYPFSSERQRMTVVMTIFKKHFLFIKGSDQMVLQDIQKMKIDKDLQIFYCKVQKIINSNSDLRSLVFAYKEINSKEFVNFKVIYENIGFEDRKQLLDKLFTEMETNLIYIGTTFIEDKLQDNVSQTLSALKMAGIKTWMITGDKRETSISCGINCGILDRNWESTNKSIVEKPRFIINNLKESSSVLDCDSVIIYRATPEMKAEITKLLVKKRKNVLGIGDGNNDVPMLQSSCIGVGIQGKEGTQASLTSDFSIPEFQCLKRLLLVHGRYNFMRFSKLTLNSFFKNFYFILIQFYYNFFNGFSGKPIYNFFFLNYYNVLFTSFVPLSICLFDKDHPEEYLMENPRKYKEPRKYFSNLEIFYNLILSLIKASTVFWLSFGILYINGFESHNGLVCGYTPMNNYFSLIVFTTILVRQIRSISFFVIFSYIGIFLSLFLYFLTIFGIQEIDNEINGSSLNLYGVPLFYLASLCIISLTVFVDYLFDIIYDKYHYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J5</accession>
    <name>A0A4Q9M2J5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0008p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="107" mass="12777" checksum="D8447F417328DAF3" modified="2019-07-31" version="1">MKLPPVKTFSISSPFPNKNIIQLAGVVIYKDSYYINIHDFYGERKLYNRKFSDIINTGSYLFTCKVFNDVLFVIKIEKISVYDEIFFWIETKSYQRILRLKTSKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L2</accession>
    <name>A0A4Q9M2L2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0174p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18716" checksum="2C58868FD313A750" modified="2019-07-31" version="1" fragment="single">EKLRKYDLLANELGLIYKCGVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGIIMRSEMHEEPIPPLKEAKTEEDGSKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3A5</accession>
    <name>A0A4Q9M3A5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0157p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000157">
        <property type="protein sequence ID" value="TBU19996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3A5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0157p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020579814" evidence="1">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="514" mass="60277" checksum="FAE83BDBBCBD040B" modified="2019-07-31" version="1">MLHFKLKLLLWFLDFYDVTSVSIHIKNIDEDFYMQKLGTPYLNKEYLSTLKQVRSMNKTEFVPSLINLIHFGIQGLYCPATYQNSMIDLIGQNMRKVNKIFCGELNLPDIFQPMIRSFKLILPNLKELFLNGVNLDICIATELLESNIKHIEFHYCDFGIPDCNELLNFNSTGVFLPKKISITDCYLLPEVFEIVMNSKNIYCLVLKQIKNLPECFDQEFSLQPNLYESLRILKMYEINFSEKEFNFISNFTNLQKLDIKIPNNNNEPLSLDKFNLCSLSHSLVTLKVEGFENFTLKTIETLKYLQNLYIRDSTIMEFNLFGCFESKENLIHLDLFYTTIKDKQSLNLLSKCKNLAVLRLTHCLLKETEFGFLENANFRENITELYLKGNKINSLVLLKIFEYRKIELLSISLRETLQNVFSVFENCKFITTLKFLFIYDGILNEQDLKTIFSFTHLKYLILENCIIIEESSKVLNRLSDLPSLKIFKIADSTISCYDKNIIQSFYETVFSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3L5</accession>
    <name>A0A4Q9M3L5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0118p0060</name>
        <name evidence="13" type="ORF">CWI38_0579p0040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000579">
        <property type="protein sequence ID" value="TBU12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000118">
        <property type="protein sequence ID" value="TBU20181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3L5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0118p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0579p0040"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU20181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="18896" checksum="F0190038B90C8C85" modified="2019-07-31" version="1">MNNNYKIIKENKNTRDIKKWALNLTIENMKQYNSTSLYKYTKNKSISNKKSEFIICYFLNKKVGFCMIRKENRLIFIYEIHVTFEHRSKGVGTLLLDFCKKYYLNQKKYENLVLFVLKNNYKAISFYEKNNFLIDKSYDDSILHYCYKFNLNNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Y3</accession>
    <name>A0A4Q9M4Y3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0041p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000041">
        <property type="protein sequence ID" value="TBU20641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Y3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0041p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1179" mass="136900" checksum="54C243245F1DEFE1" modified="2019-07-31" version="1" fragment="single">MNLKVFICFCETIFSAVKSFNEPKYNVDFVYDMLCKELFRQYKAKTLRMNEALEYDYFFLEIKKKFINECVFEISNYFYVKKAENVLLYLILKIYDKNSMLKIKPELILNIKSDYIFSLERKNIDLVFKNSILYFHKKYHTTKLLIRDTRDKYVYKFLYKIVNILQKIIEIIGKNGRLSVITSISEGYLMDNNSLENILECITLEKKCYSNYNYNIIITRSVKNKKQTSMYANKMINYGFTSCFYRALSFFLLMKLENGLIPIIFEHSLNHSININMQNTLVHSTIKRFYFFEAMISNFKSQILKNRKEKTIESSVIFYSQNSGISIILEKPEHKNNKIPEVKRKNFVLTIEIKYFSLPTDKFVIHYNNKNNTVVEIKYEGTHYMDFPNQSSMNEKLNFKNVSSEISKNTKIKAANDAYEVKKCDSGIQKPKHALTCKIVLDTLPSPNTPLPSSVEVSSCEPSYDMTNPCTLAIPEGNRLMALRTIFYSTRIVFFCSTDKLHRYYNEKFGCTETFEVIATCPADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYPGAYVPESITEAAYIMQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTSDNVTHLSEALVKNNESLNVFEKKITMHEKNRMFELFRGRFYRGRDEIVSFWSTMWNKNDDTVTYDDYLIPFVSNNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIEKLTTLHKYFYDIVKVICLEGTPQADWFYCGLTYLIRKGIRQRGSNYRPITCMSNLYKLTTKCVTKVGQLEVERRGLLAENQLGAVRGVQRAKEQALLNIALNKDFDSIDHAYLTQCIENLDLPDGILKFIKVIISKWKTDISINKEKSATNDTCCEDTATLLEGVGVYKYVRVGLQAEEFRQVTISIKLCPPILNAKKVFSVINQPAISLIHFHIGVLRLEPADFSKLDDAVRAVLVKKKIHLRPGCKELLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M569</accession>
    <name>A0A4Q9M569_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0031p0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M569"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="8957" checksum="F351F571FA559223" modified="2019-07-31" version="1">MLKYIENKNIKLKEKKGERSKGEGSVKEREGVIAEGVNYITSITNTKGVLIKMYYNTNTKGVLIILLQLLLLKGCYSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX45</accession>
    <name>A0A4V2JX45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adrenodoxin-like ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1780p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001780">
        <property type="protein sequence ID" value="TBU10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX45"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1780p0030"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF72">
        <property type="entry name" value="2FE-2S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="14722" checksum="1EF1EE727D1BEABC" modified="2019-07-31" version="1">MLKNLGGFPFEKIKNTINVIFKQSENTKNIKAQQGDTILSTAHKNNIDLEGACEGNLACSTCHVILSKQLYNKLDEPTDREYDLLDQAFSQTSTSRLGCQLKIDDRYTNEIIVLPSATRNFSVDGYKPKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXE5</accession>
    <name>A0A4V2JXE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1166p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001166">
        <property type="protein sequence ID" value="TBU11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1166p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11227" checksum="44B72346B44FCB91" modified="2019-07-31" version="1">MNVEAYIHSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGGTTLEEPTNNINEDSDLEEEKIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH7</accession>
    <name>A0A4V2JXH7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CWI37_0290p0010</name>
        <name evidence="21" type="ORF">CWI38_1007p0030</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FI-OER-3-3</strain>
            <strain evidence="21">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01000290">
        <property type="protein sequence ID" value="TBU03467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001007">
        <property type="protein sequence ID" value="TBU11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0290p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1007p0030"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU03467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="332" mass="37546" checksum="FF6D97F565118BA4" modified="2019-07-31" version="1">MLVFVSTTLLSYYTASFLISYLSKRLKITGIDCHKKDKPVITEGLGVGSGLSFCVSLLLLMIIYKNTGKEYMNYYGICSTLLFTLILGFMDDLIDLEWRYKLVVPAVMMIPTLLLYNDSTYVILPLFGLIDLGSLYYIYMILVGIFSTNCINILSGINGLEVVQVMILSIFLFFDGVLSHDIFMVRCASCLFFSSLPLYFKNKYPAKVFVGDSFCYFGGMAISCVCILGHSTRTLFFLLGIQICNFVISLPQLLKIIPCPRHRMPDFDGEKLIASKWNKKNINLTLLNVILCLVGSMEEDKLCNLIGGLQFLWCVFVIFVKYSFFVKVVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT3</accession>
    <name>A0A4V2JXT3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0564p0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000564">
        <property type="protein sequence ID" value="TBU12992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXT3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0564p0030"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="823" mass="96293" checksum="009CE0033964B294" modified="2019-07-31" version="1">MISTQPPEEWPAFDVIISFYHTTLPFKQVIKYLSLNYSYCPNNLLLQYALFDRRIIKKILESMNVNTPRSIFYNKTPLAIPNVIIKIIEQRFCIKLDFEFEEMKEFEDSIQIGNKIIKRPFIEKPANNENHNIYVYYCKNLGVRKLFRKSANKSSSLVYDLQGVRRDVSYIYEEFIEGDNRDIKVYAMGGATPYAETRKSPTVDGVVERDEKGNEKRAKIILKENELNWARKITLGFKQLICGFDMLRKGEESYVIDVNGWSFVKGCKEEYYENCAQVIKEDILKNFSGAIGFNRLINESKFKKNINFDISQLKYLNENIKNILDSISRKSLSKVIRIYRHADRTPKNKIKVLIDKSGSITTTSGLFECIENHLQNCSFTEDLINKFGKNKETRIQKRLLENENVEIILKWGGRLTHTGRIQSEETGENLRYFLLSNSLASINLFNENKNIDDTFNRLLDNVKFFSTSEDRVQESAMIFAKAFTRKGASVVIEETNPINLKENRNKFHENIKDKLKNDFEAFKSDEINEEICKTLDAFFEYKESKKLYMTSETKYLDKNEDSILNQSQESLSHLIFDNYLCNSEIYSEKKNSKSLSSSNSSSKESDSSLFDCLNLIENKYEYIFNDKEYLGNYFEKLIYKTKSKITTNNISELYELLKYLIIHKRKDLLQIFNQEKTEKLFSLVLKYHKFINMRKYGVNIEEIIKSSEFFCGNLINKIISNLNSTDGTYIYFTKENNIHALFNLISNILPNKNINFNLTNFELDYLSYLSFLVYNDIIVISVNKGYVCDNIFEQSLDARHCLKMDNDEILGIISINDFISKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT7</accession>
    <name>A0A4V2JXT7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0539p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000539">
        <property type="protein sequence ID" value="TBU13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0539p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="30132" checksum="F63FC9F827BB3D1C" modified="2019-07-31" version="1">MYIDYNDLADGLYCTEWSQHAFIKNEVVGNFKTKDDAKNLSLEQPVYWLHHEENLENDHGFATNVLQYNFSEINYLFRQLTGFITENELLENNYYFKDCRIVNIGYKKENILDNPQVYDFVDLLEGLGNIKISFGQEYHESEDRIRDNYICYLKTLEIIENFCIRFLNWEIYKIKNDILKFANIETMGLDNCIFKDTQLYNLMPLDICEKISHFEFKNIKITKSDMIFLAVPKNLYSLKVSFCNLDDDAFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXZ9</accession>
    <name>A0A4V2JXZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0330p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000330">
        <property type="protein sequence ID" value="TBU14196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0330p0010"/>
    <dbReference type="OrthoDB" id="2194086at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="330" mass="38764" checksum="BA001B9010050C4C" modified="2019-07-31" version="1">MHVSVPIFIENEQSSISFTSTFLIFEPQNIKISFTSIKSLHTKDSTDFYCLKISSDESYTLKFTNLHIRDFFKNLIMMNVINEKKIKSDILKSGCKGEYEIVSKYFGEDTYWQMRGKMVNEYLQNYKSENNVGSVVSMLADNEILYSCYVKMNVTLNQFNNIYKQSYFFDVRNDKNSVDRIISEILAQNEMNFSSRLNSKSVMEIGDVHELVVEEKNLEEKIVDFEPIYPFNDESTSIENQISNEFSFPKTVNLKCNLNLKIDEDKPKVSLDSKEHKELIEMCRVAFFWGENQEIRSKIIEISDEFIKRVKEKYGTEKYFVSLIPKNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY44</accession>
    <name>A0A4V2JY44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0226p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000226">
        <property type="protein sequence ID" value="TBU18873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0226p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="18860" checksum="950FA4220CFEBF2B" modified="2019-07-31" version="1">MFYQKEISIITHLTDKPQLDSYLMEEKYIVINLIEAGIPSQGSLQTVKTQKFRKYDLLTNKIGLSYKFGVEIILSMYLKRLHIPMNIEAYIQSIDQSGKSWERASLCQQEEEEDGGKKENTKNIMPHILDDITTVKEPTIYINKESDLEEDNQVVEKEQEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY70</accession>
    <name>A0A4V2JY70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0157p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000157">
        <property type="protein sequence ID" value="TBU19993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0157p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020662506" evidence="2">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26103" checksum="A68786A4C19D8648" modified="2019-07-31" version="1">MILTMYLIGFYLSFLLLNIHCSMPRYGKIYRNRHRNYRYSPGGSNIRNQEVGHNLLQSNSRDLNSQDAYSSLYSLSLNNIEETYSRTDMNHSDNTLSATSHVSSTSVQDDTEEVEIRTSDTGQISQSSSLVLEDSQQPEPSTAFPILISILQSVEPIPIRPISEQSSSSQHFPEQPIQSQQFSNASQPDILWEIITAPLQQQFSADLIIQNNEVSSSTPEYFSMSNLTPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUX3</accession>
    <name>A0A4Q9KUX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RNAse P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1663p0010</name>
        <name evidence="6" type="ORF">CWI38_0128p0040</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001663">
        <property type="protein sequence ID" value="TBT98643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1663p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0040"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT98643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="139" mass="16315" checksum="C66D3D631E3F3D23" modified="2019-07-31" version="1">MRKPSKKVEKKPKIHLNIKYLLDLAVKTLNHSNYSRKLVKTIVLLTQKYQIRLSKIIKRNICFECFRILIPSINSKSRLSKEKDGMKLIITCECGISKNFVLKGEKGHRNTNTKRSRYFLCSEDQNRDIYSIHSTQKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KW61</accession>
    <name>A0A4Q9KW61_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1448p0010</name>
        <name evidence="11" type="ORF">CWI38_2519p0010</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001448">
        <property type="protein sequence ID" value="TBT99142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002519">
        <property type="protein sequence ID" value="TBU06714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KW61"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KW61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1448p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2519p0010"/>
    <dbReference type="OrthoDB" id="2190844at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187:SF1">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT99142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU06714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="550" mass="60619" checksum="4B8D37D3629D27DF" modified="2019-07-31" version="1">METETSPRDRIDPSNSLPTEAQIEAIARSGTGIWSHFKVAPQERPKFWFMCAIFLIIAYIYSVMRDMKDVLVTERLDPASLSYLKMLFVTPISILVVVLLQKPLSRYGVGPVFNAVVIVFGIYNVVYGLVVIPLQNTLEPSPFLFRDSFGDGKMAVRGLEALLGVLLTLNSYTTTIAYVFAELWGNVVLSLLFLNYSNMNCSYSQSMRFTPCLFIFSNVGLFFSGLTMLGICFVHPYLGYISNRWILRSVFIGAGLLCLFIIYLKNRLERTVLSVPICITEGSGVRKQKAHVSILAGLKELFGSKVLFNTSLIVFLYNLCTNMVEASYKSCMRVCADQKNKAVGIHVMGRQAVMQLVIAMIVIVLLLTPFSTIIQRKGIYSVAVVPPVFALVALVGVFGLAAYNTAASKKSFEWLNTMFAGASAHISAEEFVGLICVSGFKILKYGAFDICKEAISMKISASIRSMFKSVVDGVCGKLGKSGGGLLTTLTNLVLNTNDIRTAAPFSLILVVLFCLAWIKSVGYLSRKYEESVKGNCDIDLDPFVVKKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZ73</accession>
    <name>A0A4Q9KZ73_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1156p0020</name>
        <name evidence="7" type="ORF">CWI38_1381p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001156">
        <property type="protein sequence ID" value="TBT99964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001381">
        <property type="protein sequence ID" value="TBU11108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZ73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1156p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1381p0020"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT99964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="94" mass="10563" checksum="39647DF267ACDAE8" modified="2019-07-31" version="1">MQIFFQGGLNVHFDTSNLTLTSSTVEEHNIKTMSNLISYLTQHFPKSNELFTGEDLKNGNLCVINESEWEVLGGKHASLCHTDSIYFISRMHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L2M5</accession>
    <name>A0A4Q9L2M5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0755p0010</name>
        <name evidence="3" type="ORF">CWI38_1188p0010</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000755">
        <property type="protein sequence ID" value="TBU01275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001188">
        <property type="protein sequence ID" value="TBU11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L2M5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0755p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1188p0010"/>
    <dbReference type="OrthoDB" id="2187273at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="350" mass="42082" checksum="3B3E8731D934E81A" modified="2019-07-31" version="1">MVILELNRLNNMMQCILFTIFLLRFRYFVRGIEEEGYLYSIDEKKFLSYDRKNSNNDQRIYLVNDEMPNLFLMEEHFGGGDSILYLAATDKKNLVLDDSRSTYELISWEKHGSANQRFSLKMVPYNRIKLEVMGKCISTNHHSDYLKEEICDNFESSRGQYFRWIPKKYHQIVEETIDRKKYSSRDHPRRHEDRGGQPYPDEAYPSRPNHPINSYRDENYFPSRHDEYPRYNSHKPKRQESDQYHPDKNYYEGSNHAPVNSYPEYQKEKYPENDHYRDGNYDNSYQNNRRHKMAPPLPPIVHRDFESDESSFYKNINSSPSLNNDCICFDDELERKLCEYTNIQPLPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3D3</accession>
    <name>A0A4Q9L3D3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0590p0020</name>
        <name evidence="6" type="ORF">CWI38_0411p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000590">
        <property type="protein sequence ID" value="TBU01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000411">
        <property type="protein sequence ID" value="TBU13503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3D3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3D3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0590p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0411p0020"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF31">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="358" mass="42164" checksum="D4852EF265C8F00C" modified="2019-07-31" version="1">MLFLILEKSDYAFFLSNFKELAVTENYDYIEIKEFVNPIVLLVKHKISLNIKNKFVNDIFILINMKYEKYSNAIILKIFNRINICEVKNKFLRDILNIENTSNENHTTTEIGCINNLDLLENPIFIFLKENFSVILLKRNIRKNIKRSPVHEIIYSSVSKEEFYTSVKQMGIIFYWNPFFTMFSSGNNTERIRMRNQRTDNETILDLYCGIGYFLIPLLLNNPSSNGIACEINKYSQIALIKNIEVNKLQNRITICCGNHSSFIDLYINKCDRIIMGYLPCPFEGIKYAVIALKNTGTIHFHKVIEKNETESYFSKIKDHLLKYFEDVKLESLTKVKSYSVRQYHFVFDIKVLNKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3E0</accession>
    <name>A0A4Q9L3E0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0582p0030</name>
        <name evidence="6" type="ORF">CWI38_0065p0110</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000582">
        <property type="protein sequence ID" value="TBU01987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000065">
        <property type="protein sequence ID" value="TBU20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3E0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0582p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0065p0110"/>
    <dbReference type="OrthoDB" id="2193285at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21217">
        <property type="entry name" value="CH_PLS_FIM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="233"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="341"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU01987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="511" mass="59118" checksum="7E6F4FFAF28E375F" modified="2019-07-31" version="1">MTTIEEEIDRRSIDNGLKRGTRCKADNEKFEEFLDNEGKAYSEHLKSILPDGINIDNEYSVYENLRDGIILAYALDEIKPGCINFNKLTIPVNFEDKNGIFEATGNIARVLMTAKKIGIITVNIGAEDILNMHKGLVLGLLWQIVRMSLTKTANISKRPELVKLLEQNESLKDIASQQPEDLLIRWVNYHLEKSKNADIIKNLNLYTFNEGKNENKSIQNLAQVFNTCFTGRKIDLQSNNLYVSKNLQENYFKCKNFSTDIKDSKIYLILMKQIAPDLVSDEDFMCAWSESDDLKRAEKALIIAEKLECRKFVSARDIIAGDSRLNFLFVATLFNKHIGISNTVENKKDDLSEEIERYKSEMNKLHSKINELATNNDTTEIELKYKEMEENYKNELENRKVQYNKSIEDLLSSLKEFTNQVNNHVKSSVGISYDKDEEDSKKKLWEIINDLLNEILKLKNEKETLNNSLDSKKAVDKLIDKKILEYLEIQKKMQKNEIKKKKKLMCSIFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6B7</accession>
    <name>A0A4Q9L6B7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0409p0010</name>
        <name evidence="2" type="ORF">CWI38_0522p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000409">
        <property type="protein sequence ID" value="TBU02816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000522">
        <property type="protein sequence ID" value="TBU13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6B7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0409p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0522p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU02816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="303" mass="36325" checksum="E0E86AF067F66B33" modified="2019-07-31" version="1">MKHTFWTVEKKCKSVKKYIEEDISHKKLDFLKDTSYYLIEGDFPSFEIKYNNNLCYLITESNTFLMKKVMHSNTIIIKTDKTLPITNIFENSDIKSKTNEISDKIIVSKNDYLKTKSYNLVLPDFIIFPVLQSINYENFYKMFAASTLYDINLINLDLLCVSETEKKILIERFKLVCESKSLYFRLSFSQIKNILSYYRSVILTNISKKDQNDVFTTNIKKELEIYKTNIIDWIFKYFNGSIEEFLFYLIIESIETENEDFFLYEIKNYIFEKPDKTKLREYFLEFCILDEWKSKGLNLIDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9F0</accession>
    <name>A0A4Q9L9F0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0215p0020</name>
        <name evidence="2" type="ORF">CWI38_0813p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000215">
        <property type="protein sequence ID" value="TBU03895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000813">
        <property type="protein sequence ID" value="TBU12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9F0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9F0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0215p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0813p0010"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="248" mass="29354" checksum="38FD6BFA2B350ED0" modified="2019-07-31" version="1">MSRESENVENIKNVENASKKNTVIYIPITQDRVNEFKNQIFPLNSDILFVFDIEDTLYRIDKEITDLKLKIIREMAQHFKISENEMIKRTAKYTKEYGSPMRGFYDHFKIEPDVLEKTKDVFVDLSHKIDFDIDLIQFLKNLPGRKICLTNSNLKHSSHIFKLKRFDEVFEALIHCDYGDLKYLCKPKEEVFKFVEDIFQVKNTSKIMFYDDLDENIKAAKDRGWNAFKVDLTTNTIQEIVKNSIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD36</accession>
    <name>A0A4Q9LD36_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2702p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002702">
        <property type="protein sequence ID" value="TBU05807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2702p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="15069" checksum="294DA31A2077796B" modified="2019-07-31" version="1" fragment="single">KNQATECFNSENNFNFVKSVNGINITTLYSEDFNKEIFSRTNLLNYEIFCIKIFEIASQNNTILSSYFFKNNLFIRILEIFSRNYTKRNSLYSYISDIFINSDKKFLEKLTNLYYNEVNRILNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEF9</accession>
    <name>A0A4Q9LEF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2594p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002594">
        <property type="protein sequence ID" value="TBU06347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2594p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="644" mass="76137" checksum="8FF4F11C6FCD54BA" modified="2019-07-31" version="1" fragment="single">DLNNHGIHYAAIKRKKENTVIKINNNVRDEDDKEKKTDITTSKNNIDSKNTNNDIKTYGNEHSSYSKCSKSRKKEIERILKSKKRKCLEEKSIKSDELTKLMISLEATVVEKPNFLSNEKLFELISSQLKTKYEISRKKYKQENEDPKRIKIVEQSKVDSINEDLEKNLKINFPDLLCENIFSFKIPNLSLLLLEFSNDIKETFKVLINIDFEFSKKIIKKYSLDDECLYKFFLQFKDTDNLEEYVDLIDKNFLLKYNGTLRFPMKLIHRVFTMNGKNISENFMVEIWDLIKNLKIGERFKLYNSLRIIDNDASVNTRKFLKRLCMDNIEFISKKLIDLCASSPFSVIDEIFKSFITFNSLIPLYIELIKCMKEYFIDFFHFYILELLNNSDYENFECYDASEEMDLFSLERKNIYQDIDNDSSLNIADIKKCGAENGQNENIKTLNQSNTSIHKSKKVVENNEFKKIYTNGEYYQWFTNLCFFLRSFSDLIDRKLFLEYSSTMLAQKKYLFLPLVEALLFSYNINENKGDTKYKPNCGSKTENYIVSNSENNNEYIENKLGICVSSGITDIFKVKKLSLKCKTDMCSRYIMIWNKITGGDFFEERIKDILMKKIEFQTIKYLIPYEIEMITKFLSEIQIKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFE8</accession>
    <name>A0A4Q9LFE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1279p0030</name>
        <name evidence="2" type="ORF">CWI38_2696p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001279">
        <property type="protein sequence ID" value="TBT99617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002696">
        <property type="protein sequence ID" value="TBU05841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1279p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2696p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="196" mass="23410" checksum="8AF2C60E5D968ED9" modified="2019-07-31" version="1">MEIQKNIEKSEKKEEINQLQTIKVIRPKLYIPSVERYMFKPEYENCVLRNFEKKINDPLGYMPNIMADAFYGDTRSREVSKLSELVSKDIKNVLNCTHVRRMNMEIVKYLKIQKLQTEQIIRTFYFVKKNLCPSLETKKFSYLCCDYVRRKRSVIDLLLKIQERMSQVCLKGEEAWNFLIRAYSIANSNKVKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG02</accession>
    <name>A0A4Q9LG02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2542p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002542">
        <property type="protein sequence ID" value="TBU06596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2542p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14447" checksum="C1182CF1D1D1CE34" modified="2019-07-31" version="1">MTWDDIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMETNTPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGG5</accession>
    <name>A0A4Q9LGG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2439p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002439">
        <property type="protein sequence ID" value="TBU07189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGG5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2439p0010"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="835" mass="92639" checksum="BBAB2D1AE4B3EF97" modified="2019-07-31" version="1" fragment="single">NDVQQGVNNSNIYTPNEQHPFNTNNSKQHPFNTNNTISPSYNNMSYYYLLSNERESVLVEWNNTLIEVESEIRGEEETLVFKREGCYYIQISVEGICVINKDMKRIEDIRVSVKDGNIFKGVIYILSDNALYLLRIKHNMSSGGDKGCLEGVNDSVSLEGVSNTSMLEGVNDKNRLEGVNDKNRLEGVSNTDVVLEGVNDRDNNEGVNNTTSNYHPVNNTTTHHPFNNTRCNYNTFTIINTFKGVNCFSITNNLLVIIKGCYLLIYNLKGYLLLYKGNISDISTVIHNTLGDDGVEGVSYSSRLEGVSYSSRLEGVNYKDSNYKGASYKDSEIEGVKYKDSEIKGVNISTNEQQGVNYNDSEIKGVNISTNEQQGFNISTNEQQGVKYKDSGLEGVNISTNEQQGVNYNDSEIKGVNISTNEQQGFNISTNEQQGVKYKDSGLEGVNISTNEQQGVNYNDSEIKGVNNISNTLHPVNNLSNNTHLNNNITTPLTILEISSVTNMSRIVILLKHYNGLLSIYEYRNNTLLKLYSFILFTINNTNTVFSICKDIIFIKGNDMLIVKINNLGVFIHKSVQVDSIVCIGSKEEGDMDVLEGVSDIDSGLEGVSDIDSGLEGVSDIDSGLEVVNNTTNEQQGVNHISNNQQGVNHISNKQQGVNNSTKEQQGVNHISNKQQGVNNSTKEQQGLNNISNKQQGVNNSIHNQQGVNHISNKQQGLNHISNKQQGLNNSIHNQQGVNHISNKQQGVNHISNKQQGLNNSIHNQQGVNHISNKQQGLNHISNKQQGLNNSIHNQQGVNHISNKQQGVNHISNKQQGLNNSIHNQQGVNHISNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGT0</accession>
    <name>A0A4Q9LGT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2418p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002418">
        <property type="protein sequence ID" value="TBU07319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2418p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="13973" checksum="5A0B7303E8D088D9" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKTKAANDADEVKKSDSEVQKCKLHPPAISLPPSSYTTITLPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGV8</accession>
    <name>A0A4Q9LGV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SWIRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2623p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002623">
        <property type="protein sequence ID" value="TBU06190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGV8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2623p0010"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU06190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="543" mass="62340" checksum="26BA6FA9551B3C4B" modified="2019-07-31" version="1" fragment="single">TNTSTPPTNTIITIPSFSKWFSFTSIHNIEHQAFPEIKKDISFSNIYIHYRNTLINTYQNNTKVYLTITYSRKLISCNLHMLIRIHSFLEKYCLINYKVEHRYVLQGREDIKRIRIEQLGGIVGINCDSSNKRDIRDIRDNSNISNSSNIRDNSNISIKDNNSNIRNSNIRDNNSNIGNISNINNSNIGNIRDNNSNISIKDNNSNISINDNISNISNTNQINNPTNNPTNNQINNQINTQDIPDFTTLRCGCGGGLSECCYYCDKLNIFICGECYDKGIYPMGCVSDMFIKYSKSIITCERWSLKEELLLLEGIEKYEDDWNRVSEYVGTKSMEQCVLHFLKMPISDDIIYKNIEMCKDVSISTSTNPIMSVIAFICSCVHPSVASEASKWAIQRFSDDIAKMTGVIFGVAGYKAMEQKCVEEKKVERLLQVLVESQIKKMELKIEDFKVLCGVVEKERSDLNRARDNYRKEIEAIKEKIVSMRREKEIEAIKEKIVSMRRGKEIEAIKEKIVSMRRGKEIEAIKEKIVMGVSMSIGRRLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH19</accession>
    <name>A0A4Q9LH19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2404p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002404">
        <property type="protein sequence ID" value="TBU07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2404p0010"/>
    <dbReference type="OrthoDB" id="2192545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="17093" checksum="12440DBC6359E831" modified="2019-07-31" version="1" fragment="single">NFYCLIVLLSFPSKILLLPFYVSSIFNLVDFVVTNKRQYHKYFFYETCKNIIIKRDIFIFSVYLLDVVGIFVASVGMLFRISNVMTVIGYCGVVRQEYLRSEKMKIIISDFFKLLDSKVDKMPEIVKQWYVYSRDSKVKEIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHT5</accession>
    <name>A0A4Q9LHT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2510p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002510">
        <property type="protein sequence ID" value="TBU06771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2510p0020"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="23246" checksum="2E59F8326E75CD0B" modified="2019-07-31" version="1">MSKLQKKSKEIKTEEYNKLQNYVKDYKTVLFIKLDNYSTKSLHYFREVLKENAKICSFKKTAVLRVFKNVSEYFSNGIFLLFTNLEYSEIVEILLNLKDKNWIPNGVAATVNITLPKGILCHENKLEVNVLFHKKLKELGLPAVIKHDKLELNEDYDLIKENEVIDENKYEILKILKYKIGEVKIQIICGMENLKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKG8</accession>
    <name>A0A4Q9LKG8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">M1 aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_2222p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002222">
        <property type="protein sequence ID" value="TBU08769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKG8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKG8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2222p0010"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="180"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="10">
        <location>
            <begin position="536"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU08769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="872" mass="103181" checksum="5B71D623A3E0EA5F" modified="2019-07-31" version="1" fragment="single">VSISNINIDNPKTHDFTKIQISQNISTTEFLLTTKDFINTLFKDSGTKTLPLSSIDFTESKTKNIEPQNINSSVIPVPPIYQINNDISNKNDKNTDPDKIPNYDSNSEINDSELLNKNSDFLNNKINNKNHLYESITQSSNNSLTKISSGNNKNKEPTNAHLTVRFYIPTAYKLSDTFYGISIAKKCIKYFLSQFKIALKTEKIDFLGIPNFEDIAMENDSLIIFRLEYLLYNSFKDSFDHKKEVGDTICHEISHHWFGNLVTCKDWSDLWLNEGFATYYSNEILKNWTFFSLKERNKTLKYDSKSKTHIVRIKGKFENEDKTFLSKIKEFWKSSLSKKTNLKEKTTQRFYSPPNNTPDVNNYEYYIIYNKAALILRMLEVKIGKLNFKKRIGRYLFRNKGRNADLNNFLEFMRDSQDMIVEWLEKKHFPLIRVKEENKHLIFSQETYIKKFDDVKSNSSSETDIEKIKFKFKKFKNKIIEETEKNIESLWEIPLILHLNNKTITFLLNDTSLKILPDKKNNNIDSISKGYYVPSYGMFRVLYDDDSSYNSLIMALKNNLLNSEDQINLLSDYFDFIVNYGVDLEKFFNIIIFINNNDPHVLEKAIMDLKKLKSIFYKENGLQQKVKNVITYLLKDIKPNTDETKCLALTEKVINNEIEILKKMSKKYTFETEKKPDSNLKENEQKFFLNSFLSYISHKNIFKERNSKNTINSCERLSIFISAVKRINTERLFKDLLLKYDMYEYTKEKEDVITALSYFNDDFIFTQVLDLFRSNKISSDSKKLLSEKITENSKKRDFIYEYMIFFFEDIKSSTHEWPDIYFNIFITVSDKNMMMKVRNFIYQNNEFEYMREEIMQVIKENNYILESSIYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKM4</accession>
    <name>A0A4Q9LKM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2261p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002261">
        <property type="protein sequence ID" value="TBU08446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKM4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2261p0030"/>
    <dbReference type="OrthoDB" id="2186996at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="462" mass="52624" checksum="E1F4F7CB013A8D63" modified="2019-07-31" version="1" fragment="single">MPEIPHQFISNENPYSFSSTISTDPYNTKKERLESINRLQPPYIPIGIDTKSIEIERNNIVQQVKQTLIRDILVSEYNRVSCYMSDKIELEGFEEGDNNSSVLEGVSNSSNVLEGVNNSRNRVGGVNHCTNKQQGVNNSSSKQDPVNHSTNKQDPVNHSTNKQDPINNSNSKHDPVNNSTNKQDPVNNSTNTLHPFTTPTNTTPTNNPDTNTLLTLLTSYLHSINYSDTHLLSSLTKVRKLLLHTKQQTLRTSVYKSISSSLSPSQLLSSTSKHHRNTLTDLYILNTLESKYKTEQLKKQTFKKIEISRNILETHKRIINNIKIRINITEKFYKCINNLNINFYKLESKKQEKIRRERLKALRNEDEQGYLLLLKEKKEERIEYILNKTDEYISILTERIRSSSNRVGLEGVSNSRIGLEGVSNSRIGLEGVSNSRVELEGVNNLSNTQHPVNNLSNTQHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKZ7</accession>
    <name>A0A4Q9LKZ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2199p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002199">
        <property type="protein sequence ID" value="TBU08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2199p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="18013" checksum="ADAA2EDF9D8BFD7E" modified="2019-07-31" version="1">MILLICILVFTLIVLYILNRKTKKVIVFIGPRSTGKTVVLHQILENKTYNTVPTLETYTSSYITDTIPNLHTSDVLTKYNICNEKAKYFFFFSNENQLKEILNEDRIYKFLIYFVFKGKKDELVNYDEIKKKISKKRFICLENDGKNLLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP14</accession>
    <name>A0A4Q9LP14_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory subunit 7 of 26S proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1979p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001979">
        <property type="protein sequence ID" value="TBU10158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP14"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP14"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1979p0020"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003803">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="5">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19020" checksum="4DC1402877A76574" modified="2019-07-31" version="1">MAKSKKACIIFFDEVDAFACTRFEDSGENEVQRTMLELINQLDGFDSRGNIKVLMATNRPDTLDPALLRPGRLDRKVEFSLPDLNGRSKILMIHAKTMSVEKNIRYELIARLCVNATGAELYSVCTEAGMFAIRAGRKVATEEDFINAVHKVIGLYGKFSSTPRYLTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP17</accession>
    <name>A0A4Q9LP17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2035p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002035">
        <property type="protein sequence ID" value="TBU10084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP17"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2035p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="816" mass="92586" checksum="1F9C5C1ECCAF43FE" modified="2019-07-31" version="1">MFFHIFFCIAASPPENNSNAIRGDPTNTDEMCCMRISYDGITDDNSEVKESINEILKGENCKDKDQILKIASCYFNKIKDYTMKELHPFLRHFTAIICCIVYNYCSEEEYKAYHPELLFNLICFGRFVEMYKENEEYNNIVKKIFKRLLSAKTRGFEAENFQEYFKYKYKAFAPVILESFNKGDQTDLEVLKKTKIIFDGNSEPYLKRILSNARFEKFFCFMGYFKRYYFYEVVFNNVNNCVYDFSLPESFHLNCCLNRDKCGCVSQMEKSDEILIRNMNCMFNNQQYKAIIQFISKKIVAKVLNNQSRVDEIFEFNENHMNFQNTQGDRNFPRAFLEILCEESDVTYIKNLYDFLKKITKEEYHKYISAVLCLKALCLRKETLDKNNIPRIIIEFLFLADVLKKEFETDENVKNIKIYRKNNIDNLKKAVNIQNIEYADNAESEYLDCEKVPETSILLEIYGFIEFFSNDNFKTYLTNEMIKIMPEGKKRPINVEEIKNEYLKYVFLKETSGLRLEEIKLLFGKPLSKNLEKVLDPKNPQNGAQKILTTERSTQGPTGEPKKRPTLGLSQGLTAGVSRETTQGPPLTSQGPTQRQTIGVLRETSQGPTQGPTPTTPTTQGPTQRQTIGVSRGTTGGPTIGVSRGTTGGPTTPTPTTPTTQGPTQRQTIGVSRGTTGGPTIGVSRGTTGGPTTPTPTTPTTQGPTQRQTIGVSRGTTGGPTIGVSRGTTQGPTTPPLTTPTTQGPTQRQTIGVSRETTPTPTPTTPPTPTPTTTPEQRPESKMSKRSDLKTYFLYIFSAFLFFTAGLVVIILYFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPI2</accession>
    <name>A0A4Q9LPI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2016p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002016">
        <property type="protein sequence ID" value="TBU10107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2016p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="12990" checksum="D1EEE24919AA056F" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHEEPTPSLKEEKREEDGEKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU9</accession>
    <name>A0A4Q9LPU9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1708p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001708">
        <property type="protein sequence ID" value="TBU10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1708p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62293" checksum="5E94EB0E1657C134" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAANDAGEVKKSDSEVQKCKLHPPAISLHSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSSCKRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLQVLKKLAQSEMEKELKSEENGERRRIATCLTESCTLTDTTEYINLRDKFLSKIKQISQKEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQKENIESKISKLVLSKDLLEKACKQEKLSTSGTKSLGKIRREFNLDLSSVTDLSEALVKKNESLNVYEKKITMHESRFYRGLSERVESEHVVSRDEIVSFWSIMWNKNDDTVTYNDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIECIYNFFIKKLTTLHKYNYDIVKFICLEETPQADWFYCGLTYLIPKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQLEVEKRGLLAQNQLGAGRGVQGAKEQALLNIALNKGYGNNLKATWIDVKKLMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPV9</accession>
    <name>A0A4Q9LPV9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1922p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001922">
        <property type="protein sequence ID" value="TBU10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPV9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPV9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1922p0010"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="30072" checksum="4E40C9BABE44E932" modified="2019-07-31" version="1" fragment="single">MPKPQYFLPLNTQITDPSTKITYTLTKLLGRGAFAQCYLAITDTKKVAIKIVKLSDLKTEKIKEKLESEVLIHKSLNHPYIVTLHTSFRTTEYVFMVMELCENKTLDDLLKKCQCLSEKYVKKYTLQLICALKYLHENKCVVHRDLKLSNLFLDTNYNLKIGDFGLSAVIRLGQKKRTVCGTPNYIAPEVLFDKANGHSYEADVWSLGVIMYTLLIGTPPFQKENVKEIYKMIQQNSYIFPSCSKLNTAISQHSKTLISSILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPZ1</accession>
    <name>A0A4Q9LPZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1771p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001771">
        <property type="protein sequence ID" value="TBU10424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPZ1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1771p0010"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15649" checksum="429D8A516B9A2875" modified="2019-07-31" version="1">MSSFTLTITHTIPNPLLSRQLIKVKLAHPNSSTPKKDEITKKLAYLFQTDPSLVIVRNCRTAFGLHETTAEAKIYEEISTLNSTEHSYVIARKTGVVADKIQEKRNIKCLDLYEEICELLLRKKKEINKLICGVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPZ6</accession>
    <name>A0A4Q9LPZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1698p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001698">
        <property type="protein sequence ID" value="TBU10529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1698p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="56" mass="6274" checksum="0054C3F2A6EDB309" modified="2019-07-31" version="1">MTVETTLLIDEEDLQSWERASLSVIEGEDGVNTENTKNVLLLILDDLINVNEESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ06</accession>
    <name>A0A4Q9LQ06_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1660p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001660">
        <property type="protein sequence ID" value="TBU10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ06"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1660p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="306" mass="35762" checksum="0ADEEEB5CFD30F82" modified="2019-07-31" version="1" fragment="single">MPHLINTHIHLLTLSTSQNKEINKIIKQLTFPPTNTSLNNTFINLISIKKYNNEDITQILTLLNEYINRIPYIKRTVTTKYYNNIDANSRDMESEGSRDGDSSRIDINPYTNNPYSNNYTNNYTNNTITNDPYSNPYTNNTTINTITNNPYTINTVTNNTTINTTINTITNNNHPYQHTPNNNQSNNNTFLSTLTPLILTLKISRFDKDVELTLYIYFKTLYTLFTTKITPSLQKDIFFKFYFFLKEKIVKKILLLQINNLFIKIIPFYFNMFIDNNLYIGYPYLSSIISSMVYGYSGYDNRYSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE4</accession>
    <name>A0A4Q9LQE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0009p0010</name>
        <name evidence="2" type="ORF">CWI38_1673p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000009">
        <property type="protein sequence ID" value="TBU05476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001673">
        <property type="protein sequence ID" value="TBU10574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0009p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1673p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="402" mass="47510" checksum="5FF41EDB17E357A5" modified="2019-07-31" version="1">MFLLKGNLYTVDDLNEKLTESLKEIYEWKEKTMRRFSNSDFYDIKLEKPILSPEMNHLVCNYINSSASRNFNIFLEYICCKQRARSIPDNIYFFTLNKLENNDFMFGIKYKNKENKTGTIKEKHIFLKNKAIRILLGFLFNLSLVFRKYYPDSIRTTGFYYKYSYANYRFMIFDSEFCFKNIVDLPNKSLMGHASLLLGRFKPVLSTKIKLSGKLPGFQPINDLDANLKKSFNLFSTLKANYKIKAAWRFENGFVEGEYERQCNLKTFVTEKIQELFNEKNILNTELLSIQEYSSKCKFSTDGLIGSPGYRREIKIHLSWQRLPYSVQFFLKESNENTRKYGLICSFTSNDAVEFEILSDKDLIITKIVKITKERFVFRDLLASYEYEETIGKYMKEIMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQE9</accession>
    <name>A0A4Q9LQE9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1615p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001615">
        <property type="protein sequence ID" value="TBU10678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQE9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1615p0020"/>
    <dbReference type="OrthoDB" id="2186631at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14719" checksum="8980CB48D90353F7" modified="2019-07-31" version="1">MKQTLESDIFDIKKLEKEQSDKILNILKDSNSYLTTYNQLMNIYEDIHGKRVSYIFVCQDDIQHTFIFQHLPLFARHYNIKLYKFPKGTQKVIEKICNKKFVNIISIFKDDPITVKIEKIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQS5</accession>
    <name>A0A4Q9LQS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1484p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001484">
        <property type="protein sequence ID" value="TBU10903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1484p0010"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="95" mass="11183" checksum="4219E3DBC1703CA9" modified="2019-07-31" version="1">MEEIMDKLKEIEGLIDSSKKLPQGIIESLEYESKMLFTYLTLKIALGKLTNTLDIKDLERIKSLKNNFEIVKERKNEIFDEKVENDVLKCLYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR45</accession>
    <name>A0A4Q9LR45_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate transport protein Pho88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1583p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001583">
        <property type="protein sequence ID" value="TBU10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1583p0020"/>
    <dbReference type="OrthoDB" id="6510183at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="311" mass="36591" checksum="9DA112F18C20025C" modified="2019-07-31" version="1" fragment="single">MDMSNTNILWSLRIIYVSSQLLYLLLLYIIKNRIISTNDTRKLKVKPEISFFQRNDTLEEDEMVEISFKDYDYKEYSKILKGMLIQFLIVIFIHFKLSISQPLVIQSLVPFKSLFLNPLFIFYIRNNPILRPFEDNMLFQKTRIGVYKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLLNYHIGVLQLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP5</accession>
    <name>A0A4Q9LRP5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1968p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001968">
        <property type="protein sequence ID" value="TBU10170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1968p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8735" checksum="9C07009D175EBA57" modified="2019-07-31" version="1" fragment="single">MNVFFLLYFYKAITAIAKSTKHTKYTIDNIYDIMCKEMYRQYKSKVLEMNDVLEYNFLVFETLPEFFDVCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX7</accession>
    <name>A0A4Q9LRX7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1433p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001433">
        <property type="protein sequence ID" value="TBU11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1433p0030"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="56279" checksum="4503A6652A4ECA08" modified="2019-07-31" version="1" fragment="single">SKLISRVKRLCHTILNAKKLFSAINRHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEAQLAKLYNEIEKRKLHSKLYNARKNELVSISDSSRWLKKGNIRPRNEAVFCYIQDRNVFWGADGMCQHCGKSGKTVDHLSTRCEKMLSHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLTNELGLIYKVSVEIIPYMITWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKETVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREEDGAKNSKPKNKARYISQGGTTLEEPTNNINKESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS16</accession>
    <name>A0A4Q9LS16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1841p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001841">
        <property type="protein sequence ID" value="TBU10335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1841p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="147" mass="16227" checksum="5FDC5BDD46B64E20" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIKNDEINAVNNSEISFKEIKTCDRDVVTISETLPPQPTIYNNTHSPSSNTLQATPISLLDSALPSSCPDSSACGPANTMENLNAPAIPEGNRLMVLHSILDSVTAVEQEWPRSAMSAVQKRFERMPRNGWSAILRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS36</accession>
    <name>A0A4Q9LS36_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1294p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001294">
        <property type="protein sequence ID" value="TBU11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS36"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1294p0020"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46373" checksum="0761F0F5EFEA4111" modified="2019-07-31" version="1">MKINDAPSDSISDIKFNKNLLVTSWDKNIRLYDINENKQIMKLTTEYPILKGIFKSDTECVIGDVKGNINFIDIERQLLTNNICVDRGIQCLYKHNSAFLCGGWSKKIYFFDDQKVFLEKNLPEKIVCSDIKDDKIIIGMNNRVSIYDIRNFNNPIKDTEYKDTIIRSISFGIKDIDYCFGTVNGKIRVEFSNQKNNFSFNSNYQPNNNFKLMYPINHIEFNEDRLIVGGSDGLISEIDVYKKKRTKTIFKGNTGISCFVINNDKIIIGCSYLYEKGNIEHLPSSIHQIPINVEAYIQSIVLKKTVEMISFDRRRGIKSGPSTEESWERASLSVIIGAEMQKQPTPPLKEVKNEEDSVKQVNSKNVLPLILDDVTRPEEPTIDTNDKSDVEKENKVVKLMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM9</accession>
    <name>A0A4Q9LSM9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1282p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001282">
        <property type="protein sequence ID" value="TBU11287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1282p0010"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="232"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="331"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="7">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU11287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="479" mass="55425" checksum="5AB7B953C0571BA3" modified="2019-07-31" version="1">MIDINLIRNDETFEKVIESENKRFKDSNKVIEIRNLDKERIKQRYNLDQINKEININNTKIADLKKKSKNTEINKKMSNIKIVDGDKDSTKLNNEKEIIIEDINGMNEERKMNEAKMGQEDNILLENLKNEQEKLKEEKNKIITLVTEIEQQINNLLKSIGNILHEDVIVSKSEEDNPIIFTFQSDRKVKASLSYPEICSKIIGADTIRGSRISGHRGYFLMGELAYLSLSLINYAVDFLKEKNFLLIQPPVFLNKDVMAKTVQLSDFDEQLYKLEEDLYLIATSEQPLTAFHYNERLDPSTLPLYYCGQSLCFRKEAGAHGKDNQGIFRVHQFEKIEQFVISEPSQSMKIFHEMVENSVQFYKSLDISHRVVGIVSGEMNDAASIKYDLEASFPGSDRYRELVSVSNCTDFQSRELEVRFGVGKENAKKVYVHMLNGTLCAIQRTLCCILENYQSEDGVIVPEVLRKYFKKDFIPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LST7</accession>
    <name>A0A4Q9LST7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1113p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="PITK01001113">
        <property type="protein sequence ID" value="TBU11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LST7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LST7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1113p0010"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="24477" checksum="E218DD802792768F" modified="2019-07-31" version="1">MVQKITQLEAKKIDSDLFEMGFSLNSLIEIAGYLAYNIISDILKKEKLKKILILIGPGNNGGDGLVISKYLKIENYNVTIWCNKTIHPDLLKICTNLEIENVLDFEISNFDLIIDSIFGFSYKPPLREPYLSVINKIKNHKKIISIDVPTSYVVDKENTDCIFKPLFVICFVAPKFCCVGLNVYVVKCFVPRSICKYLNDLNYDSYRYYESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT09</accession>
    <name>A0A4Q9LT09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1121p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001121">
        <property type="protein sequence ID" value="TBU11604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1121p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="262" mass="31409" checksum="0893E9340E0760EB" modified="2019-07-31" version="1">MVTVRNTKILFISFFTLTFIISVYNSLIYISLIFLIIFFMNLHFYITNTLYIYTYSLFNKSLLSPLSISYISNPITQIRRFYFNQYLQQSLTYNNVYLSSKISENIILFYKIELQKCITLLSNLKNVSNNFNMSKYTLIPLVIKKENKIFEKNNSLKESKDMVFIKKVRKWNFFNIFVEYVKYRIQLHFILQEYNGCIFYLKESLVYFKKMRKEKDPFGLVDVFIKDVKNSMSVFFETGVAVQEEIKINLSVSVLFKDYEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT38</accession>
    <name>A0A4Q9LT38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1573p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001573">
        <property type="protein sequence ID" value="TBU10745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1573p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="47209" checksum="7EEA5413D7E4DF76" modified="2019-07-31" version="1" fragment="single">MQNLYKEIKINILKKDYSYALQQCDIGLSISEEDELYFLKAYILAERSDDLNDIEESIELYKILPLQEKYLQGIVKSLNKKFLLTSEKVEEENLVYYKFLCDKYFENNKIEKYQELIKKTLEQLSEGEKYVEFLRDIKIEKERYFGEYFIKIKEIYTKFCCEIYKKRVLFSEKEIKNKIRLEKERIKIDLVAENINQEIFYFDILKLHIADIYLEFDKTKKEKIDNFIKSGNKNVSIENIINLYRMDFGENRSFQPFFIDLNTEYLIEQSLFSMCLKINYTIQQKDLKNISVIQPIIKYYESVDCLKFKTSRIYDFLVKLYFDYKMFDEINDVKNKVSFEDLETLYMIIFALNECVDFENSLEYIFQNNIDEMIIFNLENNYLDCNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD2</accession>
    <name>A0A4Q9LTD2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AN1-like zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0718p0010</name>
        <name evidence="7" type="ORF">CWI38_1147p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000718">
        <property type="protein sequence ID" value="TBU01400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001147">
        <property type="protein sequence ID" value="TBU11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0718p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1147p0010"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU01400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="171" mass="19845" checksum="30A00ADF1819614D" modified="2019-07-31" version="1">MIRAFHTSTTSLHVLQSIGYSFIKKNISNTKKDNMGEINVSDGRKEISINIKEYRKVSDLTKYVAMKMNISEFWLEYNGLRLKENSPISEIKFDQTTKISVIYKKLHCFFKQCYNKAGKINSDCNYCSKNYCAKHRIPESHACIEIESCKKAANSRNEAKLLKEKLTRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTL3</accession>
    <name>A0A4Q9LTL3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1391p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001391">
        <property type="protein sequence ID" value="TBU11091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTL3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1391p0010"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="30443" checksum="56F147DB871339B2" modified="2019-07-31" version="1" fragment="single">MYLRKYFLITIVLIFINYKLILCDQDISISSLPNLIIFKRDVIFKKYKVISYLGHGVQGSVFLIEDIQTKEKFALKVQPKKTHLTCNYIAELFKNYLRHENIVEFYGYYNDSNYEYLLFEYLPITLHTYLFRNKETFINFLFIMKQMLDVLNFLRVQKIVIGDFKFDNMMLAENLKIKAIDFGHAVFEKKQKRLFSDKDIKNGKNNHKKYLYIAPEIRNGQRCSSIADIYSFGYVSREYINDVIIKDGKVSDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR3</accession>
    <name>A0A4Q9LTR3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1462p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001462">
        <property type="protein sequence ID" value="TBU10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1462p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="179" mass="20479" checksum="1A3E789EF7E88C26" modified="2019-07-31" version="1">MVFEFNTGYMCRANSKRGVVGCANKKENSKWMINKTDRGYSITYDTKMCLIKGGFDNRLTSMGYFVKLGKCETVDDDKYFLIEEISSRSKFSPSGYKKSLNKDSIEDKEHHMQDKYCPVLGTTHKQPIYDLYRELNLVSEIKKRKVKIAKNVVEIPPDRGAMENKGTGYGIIGKIVNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS8</accession>
    <name>A0A4Q9LTS8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1135p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001135">
        <property type="protein sequence ID" value="TBU11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1135p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="37358" checksum="F707080C5DD24AF5" modified="2019-07-31" version="1">MLLKLLDCLEKSKEISTRRAAILKVEKDNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSRGHIRPRNEAVFCYIQDRNVFWGADGVCQHWGKSGKTVDHLATRCEKMLVRDYTRRHNEVSSKRILSHLVQEILDNKYAEVRVDTRIKNEYNIRCNRPDIFILDKRQSRITLNEVLITSQDTHQIVEREKLRKYDLFANELGLIYKYSTYFNRLQIPMDGEAYIQSISLKNTVEMISFDRRRRLDVMLGVEMHKKPTYSLKQEPIFDTNEELELEQEIERVKMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY9</accession>
    <name>A0A4Q9LTY9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0904p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000904">
        <property type="protein sequence ID" value="TBU12089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0904p0020"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="22782" checksum="0240BF4A68EACA47" modified="2019-07-31" version="1">MKLKEIKCKLQEVKGFENPNINLEQYITPPDIAASIIYTAHVRYDDIQNKNILDMCCGTGMLTYGISFFNPFHITCADVCMNALRGCRDNILNLNIENVSMLRMDFTRLPFSYKKFDVVFMNPPFGTKQAHADTRALESALYLSDTVYSLHKSSTRSFILKRFPSAEAIACIKYDLPSTYSFHKKKNVAIEVDLIRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ7</accession>
    <name>A0A4Q9LTZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1034p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001034">
        <property type="protein sequence ID" value="TBU11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1034p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="127" mass="14621" checksum="C59189DE624345D2" modified="2019-07-31" version="1" fragment="single">KYHKAHLKRLEIPMYVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKIVKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU68</accession>
    <name>A0A4Q9LU68_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0906p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000906">
        <property type="protein sequence ID" value="TBU12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0906p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="795" mass="95340" checksum="B2ED87F60CB8A4BB" modified="2019-07-31" version="1">MCLRIYSTRIFENLVALKKFLLIFKCLICLLFPANCTTVNFIVINEENRIFNFDNRHLQLEECILEYDSLNLLYEEDKFSILKNNIICFKSISGQHKYYNPEIATIPYNKNTLLNSNVLKKIYESKQIDIRIILKDITYRSLQIFLKSLEYEDCIVNKFKIQDFLDILTIISLLDIENTKEITDYIKELFRHLIFEMINCDFEKYRDSLNYKKIKKPILIDLWILFMNIITFADKNMVRQVVLSDNRKLSLKKIEIFLSARIQFMPKLKFKLYLRFNTKSIGNLYKIYRVDYLMRTLHFLFKITNLDILYLIFGDEESYAKSIKIFSNISIHTKKLYLYFFKEPINLFINKNGTFFSKSFNILKIKYNFTSEEMEPFLVSCSKCQKITLLLKNLDSNTFELLIKFARNNPDIFYKVFYCTYILENITYDLLRSIPNNIIFYVNYNQTSMKYQQIPLMFMPFFNNYAFYYKHKEELRLPTDFIFFECSKIKDIKLDYKLSDSPFKLDDTVFTSLRYLKTIKCLSLENIVISKELLFYILESNTLIQLIIKKFICKKLEFLSDDYILYNFVLKHIRLEDSLSFIDSNISIFLNRFKKVVGLMFINADMYYKSSYLYMAYSFFVKLPKKQNNKTYLKRLEIQSASNNKNTPNILNFLSEIYIFTKLSVILYNVNQITELEYQFFSKMPELEAVFIEIRNRTNLLNFQKLFSNLKFNRTKIILDINVGKIQKEDVRIFSRCKHIANMYLSCDSIDYETVASLKKNDFKNTIFKLVKPTRAERSNEINNYLDSEFEINYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU69</accession>
    <name>A0A4Q9LU69_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0865p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000865">
        <property type="protein sequence ID" value="TBU12179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0865p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21913" checksum="79598A2914CB862E" modified="2019-07-31" version="1">MYIERTENVATSMLTKSSNSCKQVCGDKDIFILDKSENKLDSLNRNKNVVFYWTENSPDERNNFNSQLSENSNENNLCKRKVYFNNSNPEKKKKILSRVIVSNVEKFPCRFNILYNETRKNDEDVNIQVSNFDFYDFKIFLEFLNIFYLPLEKLSITNFFVLLHVFEYLDIKIDNNFIKLWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUR5</accession>
    <name>A0A4Q9LUR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1180p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001180">
        <property type="protein sequence ID" value="TBU11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1180p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="62" mass="7337" checksum="4221DD3873172FEA" modified="2019-07-31" version="1" fragment="single">NELLKNIKSENLKQKVKNEIFGNSEIFNVFFDLYKTCFLESTDTLKTLKHVKEVEFIDLPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA6</accession>
    <name>A0A4Q9LVA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1156p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001156">
        <property type="protein sequence ID" value="TBU11530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1156p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="18590" checksum="3E29E11C771E6C93" modified="2019-07-31" version="1">MRIAILFILSNILCSFYSKKKNLIKKGLENMCCTCRKPKSQDIDDFKLTAEDLHLSEERKIEKKNTVDDLHELDTDCYVIYNKGASTCTIESKKDIIYEDSEVDYLKGMDALPIFSNKLRKINDKSNSLQSVLKRNSKYMAVDDHKESSDTEEDEVREKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK4</accession>
    <name>A0A4Q9LVK4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0650p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000650">
        <property type="protein sequence ID" value="TBU12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0650p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24001" checksum="BE0B33763AFC7ADA" modified="2019-07-31" version="1" fragment="single">TRIKTDVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCNVEIISYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILRAEMHKQLIPPLKQVDNEEDDVKKENTKNILPLIFDGITTAKEPKTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVL5</accession>
    <name>A0A4Q9LVL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0644p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000644">
        <property type="protein sequence ID" value="TBU12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0644p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020878236" evidence="2">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="49477" checksum="59744A7D9003C799" modified="2019-07-31" version="1">MRNNMFIFVIFQYVGLVYLSKQRCMCEDRKYVCIYIDRTYFIKGINNNFIFTRNLFNDVEVEKSSSASSTEEEILNRLSDISHFGSNQSSKCEECSFSLADEIPVIKKIDELGPYSDVSRCNSPEGCSSKRAHSSLHSSKNSLCPLNKSGSKNTSQNYNFKLKTPPNSEANSQSSVNSDEDIQDSSLHDSEVSIQSSDTSISVPTENKSIDRYFKHNNTIESESNSLSPNLMTDVFTFQNHDMHLSIEKPVLGCDSHVNSEYESNFHKKDQLRSSEKHFFNIKDLSTSSETSSSSDKEHHKSIKTRHMFSSSRNNGHADIYSPNLFSYPNNTYTFKSRITWLENRFTYINRRYRHILARLKMLQNFSGKKKMQRNLLALTNRIQLLYKEFTQTTFSKENQFIEFENNLFNEENFMTELEIALCDLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB6</accession>
    <name>A0A4Q9LWB6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0704p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000704">
        <property type="protein sequence ID" value="TBU12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0704p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="YheA/YmcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="44291" checksum="E9EAF377EA109169" modified="2019-07-31" version="1">MEKEHKIRIIEDSRGIPTRSSFEEVQSKLISRVERLLLRLEPADFSKLNDAVRVVLVKNKIHLRHGCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEILTRRAAILKVENNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIKNRKLYSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGMCQHCNKSGKTVDHLATRCEKMLDHDYTRRHNEVVRCLHLLLLNRYKIHSVQEILDNEYTEVRVDTRIKNEVKIRNNRPDIFILDKKKNMLAQIKKNLIFIGTMNVHCKIISILFSNEFQLNFKDINEDDTDIKICINTKAITYDDFLYFIRIIKDKYEVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ5</accession>
    <name>A0A4Q9LWJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0527p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000527">
        <property type="protein sequence ID" value="TBU13113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0527p0020"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="278" mass="32345" checksum="F55686FD6AE03E8E" modified="2019-07-31" version="1" fragment="single">NIRPRNEAVFCYIQDRNVFWGADGVCQHRGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVAITSQDSLQICSVEIIPYMMTWDGIVTKYHKSHLNRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNTKRASLSVIMRAEMHDKPTPSLKEVKRDEDSVKILKTKNNTPHISQGGTTFEEPTNKINEESDLKEETVLVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWM8</accession>
    <name>A0A4Q9LWM8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0835p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000835">
        <property type="protein sequence ID" value="TBU12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWM8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0835p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="45897" checksum="DA9EE6745A96FD84" modified="2019-07-31" version="1" fragment="single">MIIYVIILQNVLCTNSDAAKQSETDSILERQVLAQYEAFRIAQPNDHANKYLHIILTNRYRDCCDEASLGLAYAKRLVDVYLQGVKSLVEECFPETIKKQKEIVRRQNHGNLTNQKTIYESLLSIFIDIFIRKYLDNLKPQNILNEEELKMYKESFSLQKDALLLDPDDFYLLKLTKTPLLTKKQKNEKIDANMIDKTFRAILIKKVFILIVKCFKNLSLNFSELSVYDIEKNTETLKNEIDKNAFINNIKKVYKKNKSKVPPYYCVSSRSSSYLNIFGTSMKNVYDLHTPEIVSNYFCDEFPDDFHINNFTMSFNYSNIHALYPYKMDISGEVFPKSMKDCFILAYNAYSSKVKPKKVYLTIFLEIEIWLDIFIDQILSELEDKYLDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ7</accession>
    <name>A0A4Q9LWZ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0829p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000829">
        <property type="protein sequence ID" value="TBU12255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0829p0040"/>
    <dbReference type="OrthoDB" id="2428500at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="168"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="28398" checksum="3DBF44F0C970102D" modified="2019-07-31" version="1">MSNSFSGKNTNENKYHFHVSETQECIEYVNDNDIGRSFYICNCLDVSNKLPEFNCIIKRYLKTGLVFVDKRGGNRRSKLTLEIKESLQTYVNLECTKTLYELAEWVKCTFNVDVSTSTIDRALREFHYTLKRRKSVPERRNSLSTLELGTNYATSFRELEVDNDDKNFVFLDEVGFTVVTRPSRGRNMRGKSAYLSVTAARSRNISVVAAMNKYGMIYHKIHERAVKGEDFKLSIKEIDESCQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWZ8</accession>
    <name>A0A4Q9LWZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0783p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000783">
        <property type="protein sequence ID" value="TBU12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWZ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0783p0030"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="35"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="29845" checksum="E244BD760C3B2441" modified="2019-07-31" version="1">MFYENLRLASKNFLGFYCCYKLYMLSVNNIKEYFIQIYRFVFFRRPKKIFYRKHVDEFIFELIDYLKIHGVNHPGIFRIPGNKIEYENIFKTIETDKTYEFEKYGIDTNAAILKLYIRKNLNGLIQKSIVPTLNRLFLGRVNSDEIKIIEKYFPFTFCEDSRKLLLAIFDMFTLISNNSHINRMTLEYLFIIFSPTIFPEMLIQDLEIIKEQIKFLNTTIFFEYNRIPDDIMIEMESFIRNIDFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX43</accession>
    <name>A0A4Q9LX43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0763p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000763">
        <property type="protein sequence ID" value="TBU12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0763p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="19245" checksum="87608DFDC7DEBE6E" modified="2019-07-31" version="1">MKTNFLLYSVINIIGLFSGKIRCGSFSGDAGALVGGNNNFSLNVTNNNTSNELLAGAAKLSGEIGLGADVGSNLCAGLGGNLGAGLGSNLGAGLGGNLGAGLGSNLGAGLCGNLGMGLGSNLGAEMGLKFRRRIGYGFGWRYRYKQWLSNGGVGLGGGVGLGGGIRGNSGLGQDRIYDRYTPVEDKNLFACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE2</accession>
    <name>A0A4Q9LXE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0456p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000456">
        <property type="protein sequence ID" value="TBU13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0456p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="873" mass="104312" checksum="7E7D947774CDD12D" modified="2019-07-31" version="1">MLQDLYVKDIEKQFAIKKCHYSFFIILNVFCSVYVTNVEFIVINDENNTTGLSISDLPMKMTDSEIYFEELINEEYKIIVYKNNILRFESYNQKPRYYNPNIMGIPYRNNMLLSSRILKQLFESKKANIKIIFRDISYSSLLLFLKLIDNPDIVVNQIKVREFLDILTIITVLDIKKTKERNDFLKELLRNMIFTMKDANSIFDIEKYYKNYHYKHIKNSILMDMLIFFIEQITFNDKSAQRIIVLSDMFHLNINFTKVFFSHDSPHRQKFEDKVCLRLDTLNITKLHRMIHIEHLRKTWRFILQITRLELLYLILLSEDICEKAIRLFESVTLHTKKLYILCFKNPIKLFMGKKAALFSPKLKEFKLKYDFKTEELKDILNFFSGLQRITLVAKTIDFEKLKLLVEFSMKNKTTICKIFCSIYESLNTEIALLRLIPSNLLFYIDYFEHESDSKQIPIHYMPFFYYYSYRYMHTRGTGLPNNIIFFDCSNFKNIILNFKHNSSLFELDNSAIISLRYFKAVKYFSLYNVLINKELFLYILESNTIIFFVITNFVCEYNFDLLKNSDTVNRKLETLLLKNSPSYIDSRILDFLDKFKCVTGLKLINFKTNYNKAYLKEVYEFFFRTKKRNENKICLKCLEIINILEKDKLSNILNIISETYELSRLSKITFEVYRISEAEYHFLNEMKELKVISIRLLDRVESLNFEKLFINYGSLDTIVSLIINIGRIRKKDIEFFKRLKNPAFLSISCDIIDYETIKGFKRNDFRTTILEFAKPARAERSVEINNYLDSELCGKQCFAISRIEMCFEEQKASNELALIYKFVQDNPICDDMMYPKILQIPINVEEYIRSNVLKKRVETISFNRRRGLEECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI2</accession>
    <name>A0A4Q9LXI2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0535p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000535">
        <property type="protein sequence ID" value="TBU13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0535p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="673" mass="77814" checksum="1A33D332541CB8D0" modified="2019-07-31" version="1">MLENANGFIFTRCINENKKPTQNISTSSFTTTPPHQNTDESFLISTFTNKKTQTFPPTTTTLPSFYTQHNSKEKNKTTNIFLNPFTDIKKNKTKIKTNTNNKDNNRNKKDSNPFKDNNKDNIRNKKSKNNYNPFTDNKTNTNNKFNNQYNIRNKKFKNNSNPFTDKTKQNIINIYSNPFTDTTLLPTNSINKNLNNSNLNKTNPSSEIKPTFIFEFVNKKNIKNSKFKENSKDNKKVGKNIKDNKEIGNKNIKNNKDNKENKEIENKNIKNIKDNKEIENKNIKDNKDNKNNKEIGNKNIKENKEIESKNIKDNKNNKEIESKNIKDIKELSKEVRNKNNKNIKDNKEISKENKNIKEIENKTNKELSKEVRNNKDYIINNTSNIPSNISNISSSISNPSKFYERLDSDENRNEKILKILSWGTKYLNEKEGKNEYGDKLMGLFKGSVVFKENNSFLGNSCLILEEIENEMKEIENEMLKWKNIYEEVYIENVRCVDIKKDIMKGEKEGVNNKDGVWGVNNIDSVWGVNKDTIEEGVNNKDTIEEGVNNKYAIEEGVNNKDTIEEGVNNKDTIEVGVNNKDTIEEGVNNTTDNLHPLNTPNLTLDTCINSNSILYKNMKEKLDRLLLIKKVVFNILNNNKNIAEELLKSILSYVCVDKGVDILLLLRAFSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXQ9</accession>
    <name>A0A4Q9LXQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0384p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000384">
        <property type="protein sequence ID" value="TBU13593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0384p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="139" mass="16361" checksum="ADEEBA10680649A5" modified="2019-07-31" version="1">MNRKLFKIKPNTEIIIKVFLSKNNKNPPKHILIERKKSFRGEKLRNLKSNFGNIKSISEIKNIKNMKGIENIKNIESIKNIEDIKNIKSIKSIKSIKNIKNVSLFKNLFVIHLYDWSYIGNIKDFYLPCGFMKNPKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXX6</accession>
    <name>A0A4Q9LXX6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0705p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000705">
        <property type="protein sequence ID" value="TBU12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0705p0030"/>
    <dbReference type="OrthoDB" id="2189733at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="928" mass="109270" checksum="E5AEA6C814624C8D" modified="2019-07-31" version="1">MFQIPLTLRHKISGLTSISSVNDISSLILNSTLYILLQSQKYIELVSISLVSEKESLQMKCIFPISSSLSIHKNIIYVISITESYLYIFTKIPEESNLVLFQKIKIPGFKNPVILKGGRNNSPKNEKLSIFVFTSNQIHSFCTELLDMENEKSNLKIEKIKFCKIPITPYFTKIKNISLSVFNNQEIITYNTSSYVSVYFTNGNPLIKKCKLPPFKDIFLYDSQMYIFNNQNEISVYQIHINSFILKYKIETKLDFDIKWLYLQHERDENEYFCCEKINSQIRKSNTIPLILSGKMNNKYVLYVDGYLFETNSLVKTFQTYHNTFLGMSNDILFYLPDDSNFDLKFTSDEKNVFLAVLKKINESKNRSVIFDGEEDEKLFYKTTNVCGDKEGDFICTVSSLSDTNLKNNDFLEKLIENPLNCYLRTFKVEPSCGKSKIGIFFAGIVFNGFKIQIKKEICNILYFLINSAKNGDFSKKDSFEDEFCTFLCESFICDKSIEISETKNDSFSLESLLDKLLVLNQLLQFEYKCADVFKDYSYNFCSLYSCVSSLFDSNFFNANLILKILKVNFKEINFHWKEEEKNLYLYLHGMNNFYNDLNYFNIFIKIDKLYVNNVCLFFCRNFLIKEILQYLNEIEEKENFIIKSIWEEIFMVLCGFKNKNGIKNLFLENENLQCAGCTKNDFKPLIQYDFKTQEHEYETDIISIFEYLKENYEYFGILKESKTNCYLPSTSFDIKIFEKFLIKSWIKSGKSLQLIDLFMKSLNNKFDLLCNLEYKILLKILNFIENEISMTKESLNNIIPFLKNISTNQNINSPEYDYFISRVKRVYGKVIYIISEMVQDNSKKELSAQIIDSDVFYYKEFKSSDDIYNELPIVKSDIISNLENNYYSFKNNENKAVWTDVSELCNNDFFKKYQNEYFKKLEEFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY76</accession>
    <name>A0A4Q9LY76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0338p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000338">
        <property type="protein sequence ID" value="TBU13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0338p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="72" mass="8620" checksum="F6D3C3B1806CA68A" modified="2019-07-31" version="1">MRKRAGIDNDEYDDKHFKTKNNTPFYSDEGTTLEEPKIRINEDSDIEAKKLVVKWLEEIHWSVKKDSNPDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE8</accession>
    <name>A0A4Q9LYE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0334p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000334">
        <property type="protein sequence ID" value="TBU13812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0334p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="540" mass="63662" checksum="7D05C4A87AC71821" modified="2019-07-31" version="1">MCKSCRKTPNNFYPRSNNDTYNSVQGSILRSRYDGNEVLYGANIYDTLYQATSSMSNSETENIYYPVITNPTALHSQPQTLYFNPQAPGTLFTSGLREYQDNFYNNRQLNQTQGDFVINPCDSHSRQLNTSNFDSDIASSHDSISRADNRVDDSHINCFPNNTQGETLFYFRFNTLLAAILNYQKGNIIPDISIIWKHDYYLNDILISNRLEMYLNVFKKLIEIERNILEFYPYENQELKQILFEYENRIDFLKFNSNLTPTIPMLISLKRFVENQTYSDESNIKNHIAAFFGLKLIRSVMVETHRQTLSILIDAKTNSLIDADEKIDSLLKDSHDVILKIISTIFFSAFQFTKNFQYVFSLSIDLMKRRFSVVFDDGKNVLGENDLSFLPDIFFYLQESDIIEIINSYERKNREFYISSAIYTTLSTDCSIRNESFLSNELILKIIGYYFMIFDDPKIEFLKPLQSAFIIKYQYMSLKEAFSQMKNESFFCDDCYRILLRRLFCDTYYFFHFCNEYRHNPGILSKSFNKKVSRRFLDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH8</accession>
    <name>A0A4Q9LYH8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alternative oxidase</fullName>
            <ecNumber evidence="12">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0567p0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000567">
        <property type="protein sequence ID" value="TBU12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0567p0030"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="375" mass="44650" checksum="97B12EB4ABEC61BE" modified="2019-07-31" version="1">MLLKNLLTTKNPFINKESLKDITKGVIHSNNDNSILKGYIAPKRYLEITPINNREYLHKQHPSNNEDITSYKQHPFTHLYNSSYKQHPFNKQDITSYKQHPFTDLYNSSNNQHPFNNIYNSSNNQHPFISQRRFYFPQPVREEFKKKITLTQLKEINYKKDFHFKPQRYSDYISYSLVKGFRFLADLYFRKRYVHRAIVLETVASIPGMVGGLFRHLYSLRRTVDNGTSIQKLLLEAENERQHLLTFLEISKPSFLDTLVIYTGQIFFFSFYFIFYFLFPKSAHRFVGYLEEEAIRSYDMFEEEIKNKNIENVFAPKRAILYWNLPHKARLIDVVRAVRADEAAHRDTNHAFANELECVNDKRCNYKGVNNSKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH9</accession>
    <name>A0A4Q9LYH9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SEC31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0301p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000301">
        <property type="protein sequence ID" value="TBU15975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0301p0020"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU15975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="133265" checksum="57DDA8915F292032" modified="2019-07-31" version="1">MLLNKRCIVSFSSFSPTAVLATKSRTFDPSFSSCSDISLHNYKTNKTTTLDQDLRFNTVLWCESPSYSFLSAGQENGTFQIFKHYDDTLHPYYTNSTHLTGDITAMSYNHSKHLLSIGGSSSKIILYDINTPDKPFLAPQIKPDTFHISSLSFNPKVSHILCAGTTTGSIVVLDLRQKKEVLRISHPHLQHITQILWHPLSTTSILASSPTSILSFDLSTDTTTTLVTTKYLNTFSIHNSNSDNPFLLYTTPTSITTQPLSLSTNTSNSNNINIPFTTSSNNISDLQLSTYTPLLSSISYTDGKTLLTNILNIHNTPYITPYNNSNLTVTSYNLYSYNNKCYNIYKLPKIYMSSDINKNTLIYRIYSIMVDSDKGSNVLDKGKGLCRDVRKRIGDLIFSEYNKDRLEGDNDKDRLEEGVSNRDRLEEGDSNRDSSSKQQGDNDSISKQQGDNDSTNKQHPLIKSTSKQQGDNDSTIKQHPLSNSTNKQHPISTTFISFDLKDVITLSLLKGDFINAYDLSLKSKEQHPLIYTILLCMNKEEIKVKIKELRNKTKNDKIHLLLCVLCNEYKYVVDNVVLEQWYVVLYLLCYIDVCYDEYSELLTILGDRLSNSRLEGVSDKVTSVKGDNNSTSKEEGVNNSTSKEEGVNYKDKEQHPLNNSTNEQHPLNNSTNEQHPLDNSTDEQHPFTNNTYTYYSLICYLLAGNLKKYFKVRNNEFEIPKSVFKVIETLKKYGSVVGECYTMGGVNDSILMREYSKYNKVSYKDRVEGVSSKVSKMEVRGVSGKNNILEGVSNSTSGLKGVIEPTNALHPFNNNTYKQQGVGNNTYKQHPFTPTPQHPVTPSIPKPLTRQYTPPIPNTSNTGNIPTSSISSMPSTNTPSIPPSNIPPIPPTTNIPTKPHTYGQLRNSKTYGQLTSKITPPLNTTNTTPFNNKEDNIRTTGYTKPIDTNISSSMGSGYVKPLNRTVPLYNKPISPPLSTSSNIGVSSTNTYPSPPPTNPSPTTNTTTNINNNPPHTNTNTTDIINTIDKRVLLIKRLASKKKGLIYKNKINECLRRLECYNNINKNDIPIDILNKLKEVLYIVSEEEVLLCEEEKRLCDLRDVWYEKVRCVCEDIVRCYGGVKGVDVWVVGIVGLLQIGLSDRGNKVDIISKDKVGVLVKIVKIIFYYFIGKYKVSIKGLFLYIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ6</accession>
    <name>A0A4Q9LYJ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0608p0020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000608">
        <property type="protein sequence ID" value="TBU12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0608p0020"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020490880" description="non-specific serine/threonine protein kinase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="538" mass="63332" checksum="1C074C1290BB0588" modified="2019-07-31" version="1">MNRMILYFCLLGQLFGSTDSLTQDFYIGKKISVSNNLKILHSWEIQEVLGQGEYGCVYKVYDSISKEIYAMKVQCNDLIESLQMEKSIYENFSSEYLLKYYGTYTYKNWTILLLEYCSTTLEDFLKSSVKYIVKVGLIKNVIFALRFLHDNRIIHNDLKANNIMVTNNLKCKIFDFGISCYETATKHIFYNLVDGRNPCYSYISPEVRARVVGYNCNSDIWSLGALVNNIFLNVSSNISMMNFNPNNTPGNFLYSMLNTRSYDRPSSDLLIYHEFFDPLYSFLDYLIDLKNFYIYLPDNIMFIKKDNYFEIKYKNLSISLLHFSTMYAKKTIDDGIQKLTVKKYTTLVQNSYKPRFLFSKYRFYMISTDRKYYFSIVELDFYVLDLLENIVNYCRDKVFGFKSKNSFNYKNFVENLFQAIQETKYLNNINRKSTLCFKYRKEKENWKNIKSESIARETHLRNRKFTSMTQINSGGVPYANQSANIGISHVYAPVNRTANIPDSALHNEELQNFSENYAKSRSSRAKRRSGWFSLCVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYJ8</accession>
    <name>A0A4Q9LYJ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0279p0040</name>
        <name evidence="4" type="ORF">CWI38_0426p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000279">
        <property type="protein sequence ID" value="TBU03538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000426">
        <property type="protein sequence ID" value="TBU13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0279p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0426p0010"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="281" mass="33387" checksum="C5F518A4A46E1DEB" modified="2019-07-31" version="1">MSDRLPQDINNIEIPSRGRPRKKEMHLDGLTDEQRMEYFNAKGISPGQLFGDDTGMRDRRTDFNTFDYGGPQPMNNNPQQYPQPYTQPPYSQPYTQPYNSFYPEYPFYQPLNDNPWMNRKKRKNNPLLWQYIKHHQDFYPNILHPSKYSSLDFIQGTDKSQKMYIGTIKRAPPFIEKNNHNSILPLYLNSAHPTEQQHIDEFKKISTNFLNKTVELDYENVTVQQLKAIMKEFGLNHTGKKIDLIDRVKTTITKIEERKRKDKKQSQEIPEDDKDLNFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ24</accession>
    <name>A0A4Q9LZ24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0507p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000507">
        <property type="protein sequence ID" value="TBU13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0507p0050"/>
    <dbReference type="OrthoDB" id="2200980at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="33444" checksum="7DDE4F9DEEE5E0A1" modified="2019-07-31" version="1" fragment="single">MGRRKKVDSENIRNEKIKAVNNLENSAGEILMCDVDVGMLSERLPPLPTFHNTTHESPSSSCQTSPVGLVDAILSSSGTDATAWEPANGMINLNTDAILEGKRLMVLYSILDSVTVVEQEWLISTILAVQKWFERMPKNGWPATLRYYNEKFGCTLDIDAFKKLAQNEAEREIRQEENGERCRIATCLTESCTLTDTTEYINLRDKFFSKIKEISEKEIGKLPSELVDSKDLDLINRIIGEYADSYVPMTITAVARIIQVARVCYDEATRKEKPRSAWKENIESKISKLVLSKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ61</accession>
    <name>A0A4Q9LZ61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0240p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000240">
        <property type="protein sequence ID" value="TBU18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0240p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="208" mass="24457" checksum="C28DA75FC2DEC1EA" modified="2019-07-31" version="1">MVVWGVIYNNIDGVKFILKYLLRRFVYVKDRIERWCKKVNEYENMRDGMRNRKRKGAENMRDGMKDRKRFFIDDLQLLAKDGTTLERWLRRLEINKEKSATNDPCCDDTANELTLVSFEEVQIKLIAQCTSREAASFSKLYDGVRCGPSKEYDHLRPYGLHSVKFNRKHMLLPFLDCLEKSKDTSTRRAAILKLGNDNKTHLSLIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ74</accession>
    <name>A0A4Q9LZ74_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0356p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000356">
        <property type="protein sequence ID" value="TBU13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ74"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0356p0010"/>
    <dbReference type="OrthoDB" id="2190075at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="145"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="985" mass="115830" checksum="4800F6452FDE4278" modified="2019-07-31" version="1">MVEKENENKKTIEMVETDINEDLEEETSILLSDGIKSSKLDIFDDINLSIPQKDDPLVSLPVRTLAKTITESELLSLLQTADKKSSKKISKLFSLYKISDFKPFISLTSSKTRNIRFFSTICIYSKIKIFLKTKVSCDFLLKEVFLQRIKDIDPNIRSISLDYLCQWILVNDVLVKPSYLRYIGLALNDKIDNLRKKAVKIIIKLIENKNIKYSVSKIKKVSISEYGMENFSKKIQTNQVILNFLDIFMKRIIEISLYDKSNVCRTECVVLIICLYKRGFIERNKLFEILKTSCVDSSVVNIINELAYFSIGGSMSNQNIEEFNKKQKISFDESKITILDSEEETEGNIKKKYKKNELENKKEEKENKISLNTTLCENLSLAKEDFHLDFNNWELSADEETLISNIHEIYRNTSLFLISKINVESIQPFIKKINFIRKKEEICCEEAPICYFKILFSVLNPNWDSLKNLLELLKYFKDEIKIIKILIECFNKIDLSVFKENPEVTRNIYDEIEKIFFMFYGTISETESKDINIDESKNLSNFNSTLLMEDIFDSKNSEFRAPSISINANKKENRSSVNNMEATENSFDNILNRNLLESILVFMKKIEIEFSYLSQNFLELFLQNDNSNLMKWFIQYFDVTEKLNNNYDSISLCYGFIWLIIKEKYEKIKELNLTKFNVNEFSYLIDFLILFKEYGNVKIENSLNNNLNEDLLFDSPSIEIETVEKIQNILEEDILPEKIELPKIILYFDGTNVLKNIFSKCFLKLLKFLMNNKNEIHESFKILNSEEIESKENKNEQMIQTNFKLKEKSNNLIISLFKLININIFSEISYLLYYTSPDIIKEIIIRINNKEAIINGFFFYLEKNIELFKSNQNENNLNKKFAKRISLKKQKGLQNKINNYILISKSLSTKMKKENLIFKNIKRFYDKGYEYPSLNDVFKYFISNLNENECIVLESMTKDDKFKRILSKKCNKKSKNESIKEVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD0</accession>
    <name>A0A4Q9LZD0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0221p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000221">
        <property type="protein sequence ID" value="TBU19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0221p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6597" checksum="2511604C8CDEDF23" modified="2019-07-31" version="1">MVVLEDEIQEEPTPSQRQANSEEDDVTRKHKKLTYILSEIKINLTTRQMQERRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH9</accession>
    <name>A0A4Q9LZH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0224p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="30947" checksum="B424C54F88830053" modified="2019-07-31" version="1">MQDHVTTTLTSSNTQLIAAFQQGKNEMTEKLNTILQHLGQCNTTPNPFQPTNIPPTPSIPTPANPATPITSKELYERLLGVINRSLACKNCCTCTQDAPCQYILAHEIYELPFSESSWPPKPSQSGDWTENVIVEMMAKIRTTRCNTCRDCTTMINRRRLFSFFNAWQFYSLGMPYAPYMPFQQPFAQPFQQPFQQPFQQPFQPAFQMMANPAMPNPYMMMQPTSFMTPFGVNYNANPPLPKEAAKTTCESQKQENNQEAKKFGKGYGKTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK4</accession>
    <name>A0A4Q9LZK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0209p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000209">
        <property type="protein sequence ID" value="TBU19502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0209p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="18055" checksum="0F0F7B95E4762758" modified="2019-07-31" version="1">MSIENNSFVIFIGQINNKEIPYNVKIEQTNLEISFDVKSKILQINNNIALFNYDKNIIKVNAFEFNEDISDKIIKYLEAYDNTPEISIFYSFSELDFVIKLFECFKDYYGICNLISVLEYSEYDTMSSKEQFSKVKTSLNDFVKDFVFKKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZM5</accession>
    <name>A0A4Q9LZM5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0485p0010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000485">
        <property type="protein sequence ID" value="TBU13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZM5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZM5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0485p0010"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="39"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="313"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="50151" checksum="FDE727BDB2F169B9" modified="2019-07-31" version="1">MSFIINNNEIFKAKFQREEDVLLEFKNGLIKFDVASTAFEHTQKNTDNLLEIKAIFQRQLPKMPKEYILPQVFDMKHRNLFLVDDSSKIIGGICYRPFYEKYFCEIVFCAIENECQVKGRGGFMMDLFKEHCKLEMFRYYYENKTIKDVDNILSKSIGISRHPDCSKIAYVDSYLNSNYKPLISPLYFLTYADNFAIGYFKKQGFSKDIRFKNWIGFIKDYDGGTLMQCKLIWELNYLKKHEFIQNKRDELISKLEKISEFNIIRDSPDFSKMNNVYDIPGIKEAKLTNEMLIFKPSSERIRDIMYFVISELQAHPSAWPFLKPVNKQEVPDYFHVIKNPMDLSTMERNLRNELYEKFEDLTDDFFLMINNCYFYNAPSTQYFKCAQKLEEFYSTKLARFRKISSSQEKDVEDNFEKTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV2</accession>
    <name>A0A4Q9LZV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0462p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000462">
        <property type="protein sequence ID" value="TBU13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0462p0030"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="786"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1262" mass="147821" checksum="A9272BA285137761" modified="2019-07-31" version="1">MDTISSSSDLEKYSFKHKPKLECQNTQEPSSNVRIHPRVIIKRPVRCPNCNTASTKQEFSKSEIKQYKCTRCAFTFFYNTPNFIIISNQDKAKQVQIDINKPLRHFNQNNYPDKKKSLINKDITYDKNLLDYKLLKSEKKQTSQKRNTNNSHSNSINVKNRFSKPNNYVSKSKNLNFKTRHKIKTYDTFQKLSNDQINLILSGKTPFSESKYIFIYFNKIKNNKIKFYKMAIDSILESTSRYIINMDFINDDTMEIICREDRKDILIETISKLPATYIEKSPEIQDNGKIDTEKLFERLKKIIERKSNTNKKLLKFAVELTTTKRSKLLECLRSANIAATEIIHILIMIKKIGFLNIGGLSGLKINRINEILQKENLDIIGIAETWKDSVTYLHKDYHVIHMKPSIPVTNRPSNKEGMMIIGKNGLKVELINGVTEMGLTIKIDEYVFVFIYRNHFSKIPNVLLPGLGTYTNNKIIVLGDYNLEQKPALEQDILNNHIEYGLYEHEIETITYTHNDKTSTRDKIFSNCQIQIDTEYITNINHKILLLTLPIIEDIKRPKYKINLLKDKIIADNITNRIERKTLKAKPLLDKLNINDRCNMLHYIIDQSFLYIKTRTRKAQRISPIIQRVRLMREEARNTNTELYETLQKEKKFFRKRFSISDVPASRTKYIGLSISETQKIIKFNGNNIPKTNQNFKELIDKFILDGEIIPTDNIIDKIKRYYEKYKHPKNFNESNTINPFELNEVKYMITTLKSGKSGGRSGIRNEFLKICSENFIYELTQLFNKIIQEQQIPECWKKHIIQPIPKDKNDFRPIALIEKTRKLFEKLILTQLKFKIHKQQTGFKPGHSTLNHALTIDTKLRHSNGCMICVTLDIKKAYDSVDRKKLYKKLLAHQNLSLRDTTLIANLIENNEYTINGANDISLYKKAALGLPQGSIISPVLFNVFINDIINYIPKTMRNQILLYADDIIIFSERTEQIHTIIKFLEKHARNNNYRFNPSKCFYNASKEYDIKIYGTKLEKQNPLKYLGFFFNNRCADTNKSLKTVRGNCVRAAAITNKAIQNSKTSNSENTFQFKLRAYISYIRPHIDYTSALLGCNRTFIQSADRIQKGILKFLFKIYFRTPTKIIYAIFPIETIKQRANRLRYSIGTKIVKGENTILKHLFKNDNTKNLKKIKNIVKRTKRLYRNEDFKKVVEKFKKENLRINLKIFLENDSLKNFNFKKLTKHNFLIIQEILNPIHERDDISEILNLLIAANLIPIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY9</accession>
    <name>A0A4Q9LZY9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0451p0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000451">
        <property type="protein sequence ID" value="TBU13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0451p0040"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19526" checksum="B491A15734087522" modified="2019-07-31" version="1">MDINSIYAFSAKDKKGRTIKFKDFHGKVLVIVNVASMCGLAAKTYQNLADILERYYEDGLRILLFPCNQFLNKDTANLVKIGEQVNEYSERFILFNKIDISGKNTHDLYKYLTEKSPVWFKGVALSNFTKFLVDKDGKILHRYAANEHIKVDDIRLMEALNQTQKYNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M059</accession>
    <name>A0A4Q9M059_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0402p0030</name>
        <name evidence="11" type="ORF">CWI38_0428p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000402">
        <property type="protein sequence ID" value="TBU02864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000428">
        <property type="protein sequence ID" value="TBU13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M059"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M059"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0402p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0428p0010"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="9">
        <location>
            <begin position="313"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU02864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="426" mass="48975" checksum="F7AA26F3198C2EF4" modified="2019-07-31" version="1">MAKSIIKQKIKERNFIAEEAKKELKLTEILKTETPGYIESEKPTHQISQLMIKENVNILTAEKAYNLSLEDGPFFCNYTKDGRHILLRNNCGFLSSFDAKTLDLHFEINISDKINDALFLHNELFIAVAQTSSLFIYDKQGREVHCDRKNRNVNKMDFLPYHFLLVSLSKEGVLRYQDTSIGKIVSEIITKEFDENILVQNPTNAIMYVGNRKGVVSLWSPNCKEYVSKVLCHKNRINSICVDRGGNYLITSGCDGKIKIWDNRNMFNPVNEICSKFNVVESCLSQMNMLAFGYKNKIKILNNIFIKNLEDILYLEHSLSKSSVTSLKFCPYEDILTVGHTNGMTNLVVPGSGDPVFDSYEDMPFSTKKMRQENEVKRLLEKIPYELISMESLIGNLKTDIEKENEGLKEKKYKKKKGALSRFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J5</accession>
    <name>A0A4Q9M0J5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0385p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="PITK01000385">
        <property type="protein sequence ID" value="TBU13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0J5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0385p0030"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="454"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="778" mass="90179" checksum="2D6496F3AC80BB6A" modified="2019-07-31" version="1">MLSFTNDKNSYLKKYTRQLDLGCKLNKCCRIFCKRNMSRSCMQNIGKMLAKYGSVFYCENICLILQGNEFSNDYISVGCRPLDFFFYLTHILFDEDFIKVKNKGCTSQKSENCDTFINKKLNHEFCEYFNSAKFGEEDIVLIEGLLYLLLKKYEFTLEQTLGLVIIRIFNVVSRHYTLKNVYVQLFTNTFLNIQRLSKEISKDDGNECCCFEDMNKDSISSNISNESNIHSNETLKSVAENESINTISSVTKISACKSPDNYNSKLANINLKNILSAESNHTSRYSLNSAYTSNDTGLLRECIFKSKITKKDFINLVNSVSLCINSMAHVNIRESACLENLFNIFNILYTINDQEKILNYKKFYSEEYCKSQNFKEEFRSYKANFKSMLKYTFILPLRMKAEFIKSENSDMMKSCLQDMFFRALFEGETKPYLFITVGRSTIYRDTMNILKNLDDSEMKKQLKITFDNEEGVDSGGIRKEYFQLLSEEITNDHGLFEIKNNYLWFKITDKASDNLREYETIGKLIGIALYNDVVLNIPFTSVFFKKLLSKRTNTSDLQQICPDIFQSLYNLKKCQKEELKELEQTFEIAYSTNDIEITHFLVENGNKVMVDCENVNEFTEKYADFILNESISAEFESLKKGFFSIVKHSTVSYLHSKELEKIIVGTTFIDVEAIHKHALNTGFDENSSTLQNFWEIFTEFDSENRKKLLQFITGNDRIPVSGPESLKLVIMKNGCDTDRLPSSQTCFNTLLLPEYSSKEKLKSKLLSAIHMTKGFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K1</accession>
    <name>A0A4Q9M0K1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative E1-E2 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0127p0070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000127">
        <property type="protein sequence ID" value="TBU20139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9M0K1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0127p0070"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1268"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="10">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="767"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU20139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1436" mass="159088" checksum="6D94AE861B244DC6" modified="2019-07-31" version="1">MPSTQNNKQQPLGIREIQIPNTTNTYPKNIIRNQKYSAITFPFVVFINQFRYFFNIYFFLICISQCFPVYSVSPLISNIGPWALVLLLTLLKEGMDDYKRYKRDKEANSEIYSTVVIGVGSVGSGVGVDSGVGGSVGGSVGVGDTSVGDISNVSNNISNTSISNTIISNIRDISNTSISNNIRDVSNTNTNISNTSISNVIDIPLTNTPSSSLKVGDIIFLKKNQRIPADCLLIKTSDPSGSCFIRTDQLDGETDWKLRTSPHITQSLTYKEILITNLKIFADKPHKDIYSFIGKLSVGYSVGGVGGVGEGGSGEGVGVGGEGVDVGEGGSNSDSNSDKDNNKYNTYTTNTPYTNTPYTNTPYTTPHTNNTNNNTTHTTYTTTTPLNLENMLWMNTVLATGYALCVVIYTGKETRAQLNTSKPKNKYGLIESELNTYSIFLCSVSISIACIFTFLRGVTTRSDATLIRFIVILSNVIPISLKVSIDWARYVYSRVIMTDKSIEGCIVRTSNLPEELGRIGYLLSDKTGTLTKNEMEMKKVHLGTVCYTEEDEEDIRSIISKVIEGGSGSREGVGEGGSREGGSREGGVGIRDRCEGGSKDSKDSKINTNTNIHTPIPNTNTPNTNTNTPIPNTTTTTNISSNIGKKKDLYTRVFELLRALSICHNVTPSEGGYQASSPDEIAIVKWTEKTGIKLINRTRNSMELLDVNGCIHRVKILHIFPFTSETKRMGIIVEYSGVGGSGSGVGGSGKDKGYISKDSGREEGYINNTPSIDTNPNTNNNHHTNNNNPSTNPTTNNHTNHHTNNNHTNTNNNNPTIVMYLKGADTVMRTRVKYNDWLDEEVDNMAREGLRTLVIAMKYLTVEEYKEFNSLYELASLSVNDRNKEMNSVLDSFQNNMTLLGLTGVEDKLQDNVRVSIESLRNAGIKVWMLTGDKIETACSIAVSSKLFRRSDVYCVVEGLKTREEGYETMCMLTGSVGIMGGDVGGMGGMGGGSMDGGGGSRDSNYRGVSNKDSNYRGGGMDSNYRGVSNTTNKQHPFSNTTNKQHPLNTNHTNHTHNNPHNNNITPYDAIVIDGTSLQVMLDNFATEFIRISCNLSAVVCCRVSPTQKGVIAKVLRSMNKGRVCCIGDGGNDVSMITESDVGVGIVGKEGNQASLAADFSILRFCDILPLILWHGRNCLLGTGRLSHFIIHRGTIISVMQAIFCSLFLFSPINLYQGKILVGYVTLYTFFPVFCIIVSYDVKRRTVMEYPELYYELNRRKVLSIKSFAIWNVISFYQGSIIMLLSFYFFEHELFSIVTITFSCLIVNEILMVGLSVRMSRLMVYAMGLSVFFYFLSFFILKDELRMPVGVFKFLGSVLVISMCAIVFSLVQKAWSRYFAPPMHTKLEYEGGVFIVVEYIEYIEYKEVEYKEYIEYKEVLEYKEYKEYKEYKEYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0P4</accession>
    <name>A0A4Q9M0P4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0371p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000371">
        <property type="protein sequence ID" value="TBU13650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0P4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0371p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="18379" checksum="15CEE6804FB35999" modified="2019-07-31" version="1">MQNTERDTLPSSNTRIPCVVEVLTIPEHNGLMALRKILDSVTADPKYYNEKLGIAVTLDVLKRLAKNEAERRKWWCEVEERSNSLNNSKTRIMLIELSVDLENPVDIIRAAYICYSEATSKLNFRSESSPSPKAILENNQRLKKLIVSETKTKTKICESLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1A1</accession>
    <name>A0A4Q9M1A1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0064p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000064">
        <property type="protein sequence ID" value="TBU20484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1A1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0064p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="9246" checksum="E9A5F412969BD5DB" modified="2019-07-31" version="1">MTWKNLKNISVVRETNRSVFKSSFYWASYNLFPYFEFPNTRTFLTNFFFDPYCRTRHFNYNEFLNFLGSRKFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1C8</accession>
    <name>A0A4Q9M1C8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0069p0030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1C8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1C8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0030"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="49704" checksum="29C543FFF9607338" modified="2019-07-31" version="1">MKKEFFELQKKLEENNIPECPTFIPKELRCENIKNQYENLYKSVLYNVSKNHSNFPVLSDYIGIGVPADLEKISSLLTEKEISGDFFTDKLCSCQNQINNKKFTNNEFKKANNQNIENTDFSTNNSVQNKKLKETNSKENTQDQAIYDRIRSEILEGTVSIKWEDIIGLESVKKTINEIVVWPMIRPDIFKGLREPPKGMLLFGPPGNGKTMIGKCIASQCKATFFSISASSLTSKWVGEGEKMVRALFSLARELQPSVIFIDEIDSLLSQRSENENEGTRRIKTEFLVQFDGVSTLSTDKILVIGATNRPQEIDEAARRRLVKRIYVPLPENEARKNLIRNLIKEFTNLITEDELEEISKLTDGYSGSDLYNLCREAAMEPLREIEDILKVSNDSTRPIVFNDFLKASNQIRKSVNKSDLAEYIKWDSIFGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M0</accession>
    <name>A0A4Q9M1M0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0287p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000287">
        <property type="protein sequence ID" value="TBU17348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1M0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0287p0020"/>
    <dbReference type="OrthoDB" id="6623904at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="50471" checksum="BC6703581DE84298" modified="2019-07-31" version="1">MIEAPECLSDEKELVIRRAFNSTKLSRKHHLLGTEFMNQNKRKKLNYIILNTYALAEDSTGEEKKAFYALLGKVYEDCPRKYIRFLLGDMDAKIGKDYVCSSIRNYTLHKEHSENGFRLLNFAIRGNLILGTVFGSWEHTQGQMFDELEDTGSHEDTVPSYEEVHKATKVMLYKTLLRIILMYGSESWVVKKIDEKKKAVFERKLRYMPITSLGKTPAKNENIAYLLKTGWIDQIKRRNDFWERPARKILALRINKYKVRSDNGDSMDRDSNRLEVFSDRTGLEGVSDSNGLEVVSNSIDNYKSVNINTNTLHLVITNTSILHPVNTNTTIFTIWNSFVLGDCKLSKILKYFKMVWNVDISMVKIRDTVVFCTFYDNERFKNYLENFISELCCKKEGDGIIYCGVECPFDIDGYNFPEVVVDSRREREKGGIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M242</accession>
    <name>A0A4Q9M242_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7769 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0143p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000143">
        <property type="protein sequence ID" value="TBU20048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M242"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0143p0060"/>
    <dbReference type="OrthoDB" id="1734867at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056671">
        <property type="entry name" value="DUF7769"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889:SF7">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24964">
        <property type="entry name" value="DUF7769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020754159" description="DUF7769 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7769" evidence="2">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="49535" checksum="7CECB1AEC9180A75" modified="2019-07-31" version="1" fragment="single">MKIFMSKRSGFLFFICFISTTIDEFHSYYNTADTELSEIQPSNFGFNASQVFTVDYYFQNSDFIPNFASHQSFQSASGVLSHPTEENLSNSYNVFVLIQNQDMKNHYSPQESTEEKRFSKPVSGISGLLCQNPDYLQNENGLSSTINIGNRVDGDSVRLFQEQFDTSKVDPHFIPNDIHLLNNLNAAKPNNDYLEQLENKICGIENIFLENECANYSHYLDMIPALFSEIDNQLRIGIADESMEYRNSLTYDTYLFRIETEISKYDLDNIKTKKTLNEILIFAKNLIYFETSYSSSIEMHQFTENMNAIMIKIENHRNKGILYELFKFVGYYRENLCLYVEKNTPSTNMENVEENLLNSEKRDSKYKQLTKEQRQGILEKLLQQMKENKLKHGAINKVSYAFQVSRLTVSRIWHSAQTQYRKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M254</accession>
    <name>A0A4Q9M254_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0209p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000209">
        <property type="protein sequence ID" value="TBU19505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M254"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0209p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="29587" checksum="95EDB0E8ACE26DD3" modified="2019-07-31" version="1">MAPKTKRRNPNEAKSSGFLTFKSIFWDYFIAFCMYMFEAVLPIIVYDKIMGLEEKFGITVTMLKYIMLSFLYNSSFFIHIKARGFGMNQYQHYLTVIPFIFISTTTELFIYSRNLSKNYEMPAFYVLLYTIFGFLAYFTIFINFNNCKFILKEVSIRTFLCHFFYVYILIIIDNLVRKLFIFNIKELLLLKLAVYCVEMILSYIYLIKRNTWKIAFLLFIYQFVFLFAMELNTLSYFYNNLNYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E2</accession>
    <name>A0A4Q9M2E2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0266p0020</name>
        <name evidence="7" type="ORF">CWI38_0009p0140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000266">
        <property type="protein sequence ID" value="TBU03611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2E2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0266p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0140"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU03611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="300" mass="34300" checksum="763387B4A8FF0D1A" modified="2019-07-31" version="1">MENKNSEKILIVITSIISSLLTMVANKYIVSVLKFEMQFLFLGIQSTTVVIVLSILISIKIINVKNTRWKGLIRWSPSALLLSLMIYTGSKSIYYLPISIFSIFKNVTIIVVAVAEWFLYRKKIDKISYISFGCVFLSSLIGEKANFKIEFYGYFWTILNIFFTAFYLIFLKITIKKENTNDFESVFYCNLISIPILFGCSLIFDKIDIRILNFDRIMINILFWIFLSSISAFFISYSTVWCLRLLSSTTLSMLGAINKILVSFSGILIIGEDNVNIVKIISLVIGSAAGILYSFNIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2M2</accession>
    <name>A0A4Q9M2M2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0008p0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2M2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2M2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0180"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="460" mass="52705" checksum="DB32F2EA2C2E5ECE" modified="2019-07-31" version="1">MVKVDTNIYFISTPGIIKYIGCLDKGTEEKWIGISLEEPIGTNDGTHNGHKYFECEGEKFGVFIKEEKFMELVDKSVIKLIGENENYTKELENKTNFVNPIKNNDEENYFKNLSVEKPSKEKNLGSESAVRENMNYSNIFASKKESLLSPSPNILSNEKSNHSNISSPLKTNQVYPSPNILSNEKSNHSNISSPLKTNQVYPSPNILLNTNIPGTPSRKQYVAENPTIKINTPETVSSPFTIPNKNINLNHINYHKIEYVLYKAKYKKLKQKFTLLNNKFIKNREKFKEHKNKIDERVLHMVGHIIEANEALDNISNEFNKIMRENNLGNAQKPINLKEKHINLSHCDNPKPRNNLGKFVNTNDFNEKLINLSHCDNSKLENVQKPINLNDTTNTFYSNQSFTQPVSLIKNQNPDEKERLLFLLEKILSGFSLESNSNDTGGYLEEYKNILSKYGIKINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M350</accession>
    <name>A0A4Q9M350_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component Sec3 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0158p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000158">
        <property type="protein sequence ID" value="TBU19991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M350"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0158p0040"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 coiled-coil" evidence="2">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="515" mass="60766" checksum="372B00602145872F" modified="2019-07-31" version="1">MQNTNEEDIMLEDNNLLENLDKFIEETSNLKSHINSLNLIQEHCNSLASSLNLHIVKMSALSQEMENVQEKNKNLDLEIRNTTLLYDELKKLLIVLEIKDEHFEALHSLNTPISKIERALDIFTSVSLENYTLDLALEKKELIQTQLKSFFKKFSTFFATILASPTPTGELIIHTDLYKTITPYKEILKYFKKYENYTLISSVYTTFSKDTYNHELSYQLKIITKVINHDMDIKEAFDILFQSIFLVYRAENFFVKRVILPEEDCLEMLEFIFRDFNNALVNGIKKIYKNAPVTCLNALKSVIEKYRPKNSEKIFKNKNNFEIQDKESLNKSEKEEINESYKIIFGKLILEVESFYEELKQDFIQKERSQYEYEGRKKGLIRTINILKKSEIEEINSSLLSNVIESLSNYPPKKYSDIVNKRILCYQILNSTESNSFLIDSDKIRLNEFEDKVKDEFEKESIGYVFKDEEYEKRIKNIIKEIGELKIVKNEFKKICVENSDNKNEIENIFKTTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4E9</accession>
    <name>A0A4Q9M4E9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0072p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000072">
        <property type="protein sequence ID" value="TBU20426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4E9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0072p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="26253" checksum="2D0CC68D8EB47083" modified="2019-07-31" version="1">MNEYKKNGFVLLLKLSNITTLKFNKFIDTYDLLNYYSSISTLIRNLKYSIYENLLTRVEIKGIWIRDLYNVFADFPSLKCLEISSYKRFRYFSKGLNRFLQHLDELIIKNTPMHIYDIQSLLPSNIKKLSLCGCKLSNFYFMACESPDFYMSFKNIHVLNEICMRPSLNYYNDPGVAFSSNLKYMNILDSDVNITNIFAKNSSNIRNLEVLKVNIFKIMRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5Q5</accession>
    <name>A0A4Q9M5Q5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0009p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5Q5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="205" mass="22835" checksum="9C8253D643EE032E" modified="2019-07-31" version="1" fragment="single">MGTKVSEISMIIPKVQSSEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVM2</accession>
    <name>A0A4V2JVM2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0112p0020</name>
        <name evidence="3" type="ORF">CWI38_0837p0010</name>
        <name evidence="2" type="ORF">CWI38_1046p0010</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000112">
        <property type="protein sequence ID" value="TBU04602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001046">
        <property type="protein sequence ID" value="TBU11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000837">
        <property type="protein sequence ID" value="TBU12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVM2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0112p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0837p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1046p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14162" checksum="8DA122D190B0B09E" modified="2019-07-31" version="1">MDFIKFISLFQNLIFLKIYVKTIDLVFKKMSVTCTSKIYKTLKHKSKSKLEYLEITINEDITTSLPILFAWSHFFDISNLKILVLQYVKLHENDVSVISNLKSLKELHMCFYQQENEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX55</accession>
    <name>A0A4V2JX55_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1709p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001709">
        <property type="protein sequence ID" value="TBU10512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX55"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX55"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1709p0020"/>
    <dbReference type="OrthoDB" id="2192933at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="605"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1100" mass="127038" checksum="4CB3E859EF82A880" modified="2019-07-31" version="1">MIISNKIICHIYNNKPLSIFSVATNIRRITVTSSLNGEIKIWNKDFSKSVSIVNHSGSVLCVRFSYDNKYLVTSGDDNYVCVMREESRSEVGDSNKECNSISKVGCKLDNRVGSNVESNIDTKDNTNKDTDNDTNNYANKDTNNHTDNRAEHHTHNHANIHTNNNLNSYKLFKKFKHHSSDVNSLEFSNDFLFTGGCDLKVNIYKLGNFNLIYSIKVKHPIKGITVDRNSKYFLIQNENKLIIYKILNNVRNDIGNDVRNDIGNNIGNDRRNTTKNNVGNIKGNITKNLKIVVFKTIEDIFYGTVIESFFCRMSFSPDCKYVGVGLCFNNKCDSVEVLGVGKFNSEFSFIGHVAPIEVVCFNPYVYKAMKGQITLGNRDCGEIEEGSKSVKREISFDESVKGQIEVSKSNEQINEDKDQIEEDKNVKEQIEVSKSNEQINEAKRQINGNKNIKEQRNEDNGQIDEAKRHINENKNIKEQRNEDNGQIDDSFPYYVVAVASQDKSISLWNSLNEKPFVLLKNVSHQPVLDMCWSSDGNVLYFVSYDGYLRRIEFKENELGEKICKESVEETIPYEIGRYSDNIDGDIDKKEESIGIKKEESNGFKKEIKKVKIKEIKNEIDNEIKNQTKNEIIKGINNEIKNEFKNELNKIKEINNEIKNEITIDIKDTKDIKDIKDIKKDETKNENTLPRKRIKPILIAPLEDNTTIKTQGIITSIKESFLAIFISKKNNFYETSEVVPKITKSIGEYRIEVKNLPTLSSFCVWKNENIFYEIESELISHVCFNKQYFVVVSRIVGNKNEFKIVTDIRNNEDDKDWGSNGKERGKSVNLYETINNTNTTDNNTIDNKIDKTTDKSTDKTINTNTSVKTNTTNNTTDNIHSVDSISSSIFIYSTVSGILIFPCIAVSEVVMCDCSDVYLVVLCVDSIFKVWNLKKKKNIIRDNLPFNGILIGLNLDKKYFLVAKYKIKNKFLHFFYDRNMKSWIQLESMYNSIYNTSLDIPMRGETDQTVLDLEYKFSVYKHVKDVDGMIGIARKAVRLFLCSRCFNEWMCEKYFYIFKCLCDFDRKKEAFIFLEEMRCNCKLELWVVDMLERLKRYIYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX59</accession>
    <name>A0A4V2JX59_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1702p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001702">
        <property type="protein sequence ID" value="TBU10522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1702p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10317" checksum="375B97FB53E5D4BB" modified="2019-07-31" version="1" fragment="single">MTLKKYLKNSFTKKSTKKIPKSEKLYNLQEIIMKVKGKEDFEEGCFKNTILNVNEENNVRDNSLRDNVRDNEIYDNISRDNSLRDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG6</accession>
    <name>A0A4V2JXG6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_1066p0020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001066">
        <property type="protein sequence ID" value="TBU11722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXG6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1066p0020"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU11722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="365" mass="42825" checksum="F22036E8EA93260D" modified="2019-07-31" version="1">MRFLTSTAHTDSLLFSIFRKPHTISVLMAMLSMLVYLAFFYRCKSNVVTGLLVSFIVFVVVGTLFYTDGIFERPHPVLWRGVKACSVYYLMVMVFLLFQDKHNVRLWLKYIDPSLGVPLPERSYATHCDLTFTNLYNQMDIFVVAHIFGWYFKAIIFRDYFLCWILSVMFEVMEYSLQHQLPNFAECWWDHWILDVFTCNALGIHLGIKTCQYFNAKLYRWRGNVDPGFVIYEWLKGATTFKNYIGILILVIINIAIELNTFYLKALLYLPPSHFLNVIRLVIHVLMGAVALREGYSYFSDRNVKTFGSQVWICLACTLVETLVCFKYGKGEFSNPFPRNVIIFWSFLMTAVIVYPILRYKMRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI9</accession>
    <name>A0A4V2JXI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0962p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000962">
        <property type="protein sequence ID" value="TBU11962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0962p0010"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="2">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="796" mass="90910" checksum="5E072E6D11A581B0" modified="2019-07-31" version="1">MSEGNDKNSNIKKFVEVGRLVTDKMVDNRDVFGVITDIQDSKIVIVQYPSKQRKLCALRGLYLLDTVIPIKKKMTIKEVNTVIESENVVAKYEESEFYKNCLEIKRYKNLSDFERYKVDLKKEEPTININEESDLEEETKCIKIKNINSEISKNAKIKAANDADEVKKSESGKQKCELHPPAISLPSSSYITITHPPRSQTCSNMQNSGLDTLPSPNKPLASSVENSACEPSYDMTNPCTLAIPEGNRLTALRTIFDSFHKYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENLERRRIATCLADTCTLTDTTEYINLRDKFLRNSKVMVRTRKHPNELVDNKVLDLINRVVGEFAGVLVPWSITEAAYIMQAAQVCYDEATRKEKPISAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSSLNVYEKKITMHESRKQFRKENRMFELLRGRFYRGLSKRVKSEHVVSRDEIVSFWSTMWNKNDKVVLYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGIYNFFIKKLTTLHKYLYDIVKVICLEGTTQADWFYCGLTYLIPKGTPRRGTDYRPITCMSSLYKLTTKLERRGLLAENQLGAVRGMQGAKEQALLNIALNKEIHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVPRLEPVDFSKLDDAVRCSVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY26</accession>
    <name>A0A4V2JY26_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0255p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000255">
        <property type="protein sequence ID" value="TBU18012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0255p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="71017" checksum="2EF18784B6367EB7" modified="2019-07-31" version="1">MLITGKNLDTFYENGKIKILRDNAVYSITDDKKDMKYENINSKEYFYKIIDKKIFAIKRKELFIKNNDFYKKIMNFSNKKLEKSDDFYYFDGEIYFIERIDDSFCLKNDEKSLLENLNVNFYIFKGFYLYFATENSLFSYNLKNNEIFEILEKKSIVSFDISNNFIVLSDNSNKIFIYDKNTKKCLDFYHWHSNKVINLIIDPSETFILSTCDNRTVLRYDFKIFKKIFLFEYEGNFISIRIHGLYFVVLTDIFVYLYGRDTGMLESVFYTLGKINKFLLLDTSKTKPLEKKVGKDILNLKKNETKIIFENILNKDFYIKETKERQKLIFYKKNMVMFYDLESKKISKIFKVKNQIENIFLSKFYLFLLFLEKRENERNFYVVKKYKILENSFEEVNEFLIIFSNKIQNIYTDKFNNLYFRCKNMLYRLDASNVHFFVSDSIKAVFDIENYLLLAENERFRDLSSDKFNYDGNKYSFCKKFKFLNGKVYFIVKDTIYSFNFEEEITIPLLCVANIKDYYISEDEKIYLIFQEKKIIKIFEKVEDKCVSMKYVCNKEIRTDEEIHSFVTEKYLLNRRKELIFIENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVL8</accession>
    <name>A0A4V6MVL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0997p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000997">
        <property type="protein sequence ID" value="TBU11882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0997p0040"/>
    <dbReference type="OrthoDB" id="2187412at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20916" checksum="A82EC2FA8B0E923D" modified="2019-07-31" version="1">MRKMYTPNQFLEFMVDTNHYYKQFLNYIKIYEQRNSLPKIKLKIMNISENLKDLKVYGYNNDNDVFTVIFHIKYGIIGISTMFRELDAEAMRFIANVPIESQIEQIEIFLSLYYDYKWRVCDLCLSYLSIPHYLPPLIRTIQQNYVSARHKCCDQIKCELDFYSDPEIRMPDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVM7</accession>
    <name>A0A4V6MVM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA excision repair protein ERCC-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0632p0040</name>
        <name evidence="7" type="ORF">CWI38_1347p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001347">
        <property type="protein sequence ID" value="TBU11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000632">
        <property type="protein sequence ID" value="TBU12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVM7"/>
    <dbReference type="STRING" id="1176355.A0A4V6MVM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0632p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1347p0010"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="157"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="456"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="693" mass="82140" checksum="C4AC4091BB78F8D4" modified="2019-07-31" version="1">MNKEEDVEKYEKEILKKVIEDKTKKKIEKINEEIKQCIKENDTKKIDKLNQKKEKIERNYESEKLLFSDEDFEKNTFSNYEEIKPFSKHYECDNDLEKFIKERNIKIKEIYGEETEKIEDFYNFLKTQSHKLEFLYIYNPIWNILFFYQKECLDWLLFLYKNEEGGILADEMGLGKTLQILSFLSAMFQSKFIKNVLILSPATVMKHWVCEWKSIFPFERICIFHKSKSSSVEKLINSFKFFGGIGVVSYDGFKIYFKNLKKIKWDYTILDEGHKIKNMNSLIFKYVKEFECENKIMITGTPIQNNLGELWTLFDFIVPGKLGSYSSFMEEYEIPIKEGGYMNANQNQIQKAYKCSVILRNLIEPNILRRLKSKVAGQLPNKTDKVIFCSLTEEQIFFYKKCLDSDLVEGIFKGEINVLTGIDSLRKICNHLFLHTQNDKYLNPEYLVNFCGKMIILDNFLKKWKKEENKVLIFSQTIGMLNIIEKYLKYSNFNYLRMDGKTSISKRNENIEKFNNEKNIFVFLLTTRVGGLGLNLVGANRVIIYDPDWNPSTDNQAKERAYRYGQSQDVETYRLICANTIEEKVYQKQIFKNLLSKKILKNPNISKFFAKSNLIDIFTYEHNTTQIGKITSPENENVQESNFIDLHDYEFKNIIELTNEEKKIISNYKLKNILTDTEMIDFINLRERDIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVN7</accession>
    <name>A0A4V6MVN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0338p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000338">
        <property type="protein sequence ID" value="TBU13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0338p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="522" mass="63456" checksum="71FCFE1048862845" modified="2019-07-31" version="1" fragment="single">MESNLSEFKDILEKNILKTKIFCIKSKIVEFDDLLQREITENKNKKIFISLYDSICKFNCTYCNAYDHNVKIFLRLIKPEKDLYFENFSELTHKKNLKNDEYYIDFEKDLFLDENMLFEFIFKELFEIRNEEINKIRSSYKEKIRESRSILDLRTYIFKENRKDITQNLKYFIDLVIFDDFIRAEELLKNLKVEDEKLKILIDELLFYCLILRPNYTELINLLERIMTQIYCIHGRIRMIIILMIYLAEEHLYKEYLSTLYFFVNTFNYEGYELTKAILSYELSDVLLFNQTQIRKAIFFKYFSLNIFLQKHLDYSFFTDFILEKTIGDKSKNITVFHVLCFYFKKESRLLNIILRECHHIATINNNQSQVNSLIKSIFQINKFDLTLVEEFIDNKINIEIETNLIDLNEINYYSMFNGLKKSLKNEIFLNCFETLAVELGIDIEIIFMKYNHSIKNYEPKEVKYSKILENGIFKYQIKFPEEGNYKIHKFKIKYKNSWFYQIIDLTVHIERNRKFVYLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KT23</accession>
    <name>A0A4Q9KT23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1972p0010</name>
        <name evidence="3" type="ORF">CWI38_0196p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001972">
        <property type="protein sequence ID" value="TBT97972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000196">
        <property type="protein sequence ID" value="TBU19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KT23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1972p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0196p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="80" mass="8478" checksum="F103AACE121821C7" modified="2019-07-31" version="1">MVNTKKKQVDRKDDEENECASGSGSDVSSSCVSSESYSGESSYESDDGTLESSSGTSTGSYSTSSDTSNDDDYTEEDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KT30</accession>
    <name>A0A4Q9KT30_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Flap endonuclease 1</fullName>
            <shortName evidence="16">FEN-1</shortName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI37_1995p0010</name>
        <name evidence="20" type="ORF">CWI38_0181p0050</name>
    </gene>
    <organism evidence="19 22">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21 22" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FI-OER-3-3</strain>
            <strain evidence="20">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="PITJ01001995">
        <property type="protein sequence ID" value="TBT97923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000181">
        <property type="protein sequence ID" value="TBU19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KT30"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KT30"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1995p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0181p0050"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBT97923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="347" mass="39711" checksum="2805B32FC23092A3" modified="2019-07-31" version="1">MGIKQLSQVILKYNKQSIRERSIGYYSGKRIAIDASLCLYQFLIAVRSEGMVLNAADGETTSHLVGLFYRSIRLIENGIKPIFVFDGKPPHMKFEELQKRSEKRIKADEEYVKAVEKGDLGKMEMYDKRKTKVTIKHVEDCKKLLSFMGIPYVNAPSEAEAFCAYLCINKHVDAVGTEDMDALTFATPILLRNLTASESKKLPIKEYNFKGILRDLELTDSEFIDMCILLGCDYCESIKGIGPQKALSLIKKYQNIENILQNETSLEIPDEWKYKDARIIFEELVNLPCEEELPNFKYGAVNKEAIIDFLVVKNGFSEERVKKGLERLILAQKKGKTQRLDDFFKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KVP1</accession>
    <name>A0A4Q9KVP1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1902p0010</name>
        <name evidence="4" type="ORF">CWI38_0843p0020</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001902">
        <property type="protein sequence ID" value="TBT98109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000843">
        <property type="protein sequence ID" value="TBU12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KVP1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KVP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1902p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0843p0020"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="190"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT98109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="381" mass="44565" checksum="822C58E2D2F56C6E" modified="2019-07-31" version="1">MIGKIKIQDAVNNSAYGDDSLNKTVSLPFKSDELIRLFNSLEKGSMRNKKLLPVHRHLKNQMITKTDVSDKLAVICTKIDALANFKILFCEFDLKYLVRSKHSINKCTSIVKMENIRVINQKKMQKKYCKTSLRALEYKETIQYFYDKLEYNQRKKISSYCRFKLLEKPKKRCDCFLEMLKNIFSFGKNSKIDQKIPINPFIYEIGEHLLANGVETEGIFRISGKASAYRTVPNVLKDNKGYNLNDFSIHDNASIFKAYIREILNGLIPEYICGELIATIKGFPSHKSLYNLVFYSRFCFDEDVRKLIVFLKKMFITIEKHSKYNRMTFENLVKIFTPSLFPNYKHFDITTINTQIEFIDSLLRSDLQEVPLEIMNDIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KWP4</accession>
    <name>A0A4Q9KWP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1485p0020</name>
        <name evidence="2" type="ORF">CWI38_0480p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001485">
        <property type="protein sequence ID" value="TBT99055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000480">
        <property type="protein sequence ID" value="TBU13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KWP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1485p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0480p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT99055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="107" mass="12602" checksum="174882208DDB51B3" modified="2019-07-31" version="1">MGILDSKIDPIYNFIIRSLAVYRVYEGIVDSEINKYYSCIVSLVKYGISDEGEMSEFKDYFDESGNGFNNIFFLRLLKRLLQNQNIIMAFNEKDIHLEINYLHENTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYI5</accession>
    <name>A0A4Q9KYI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1133p0010</name>
        <name evidence="2" type="ORF">CWI38_0194p0040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001133">
        <property type="protein sequence ID" value="TBU00034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000194">
        <property type="protein sequence ID" value="TBU19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1133p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0194p0040"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="197" mass="23518" checksum="EB81C2D9AD38B48E" modified="2019-07-31" version="1">MIYLLGITEFYGNNGNDKIDVALSLVEHHNTLLISTKIISFFKIESFKKNMLIFRIDELNKLNIILKYKIRDFIIDNSIELVIIDSLEHLVYYEELNKEIYKSITEIITNIKQINYSLKTRFILININTNKPLTDYYNNVFGLEWNYSVNTKIEFITRNNIKFIKIRISPVLDKLEFEYQIRKGKLYFNETNIKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KYZ4</accession>
    <name>A0A4Q9KYZ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CWI37_1340p0010</name>
        <name evidence="17" type="ORF">CWI38_0068p0090</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FI-OER-3-3</strain>
            <strain evidence="17">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001340">
        <property type="protein sequence ID" value="TBT99449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000068">
        <property type="protein sequence ID" value="TBU20459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KYZ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KYZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1340p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0068p0090"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 16" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBT99449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU20459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="159" mass="18615" checksum="EBE6F1AE11AD5F08" modified="2019-07-31" version="1">MSKPTFAKEKLFPQQIGVYINPLKKADDPSQPKRFYKEIRGFKTPETAINGTYFDKKCPFTGNVTVRGRIFKGEVIRMKMDKTITVVKKYLHYVPKYKRYERRNTKFSVHMSPCFHGLINIGDSVTCAEVRPLSRTKKFVIVDFEKKKVKTDKFKILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4J3</accession>
    <name>A0A4Q9L4J3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0480p0010</name>
        <name evidence="3" type="ORF">CWI38_0196p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000480">
        <property type="protein sequence ID" value="TBU02447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000196">
        <property type="protein sequence ID" value="TBU19813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4J3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L4J3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0480p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0196p0020"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="1">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="497" mass="57858" checksum="BFF3C2F0A7B7C6D0" modified="2019-07-31" version="1">MPIRGFDILKKHIVITAKRPAAVLKDTRFCVDGFWFLKRYALPSNASSAYVFGLDFLTPIQKFISFVQNYSIDVLWIWDGIPIKSSKTDEYFEKAIHAYQSNDFSIFNSHLRRSIEFEEYVIPITELLRSSNISVIRAPYCAMAQASYLSKLGLCSYVFAPTDFLLFEDGEKLITDFCNFKDICTQVEIITRSEILHNLKLNFYRFQSYSLLLGCEFCPTIPPFSTNFDINSVISIVGGYESVYSAARKCMEQVYNTSSDSIIVEGYLKMFVTAKSLLKFHPVMKENGAVLPLNEIDVPSGIECIFGERYADSFYEKLFNVEVSPLNAPDWSENFYSSKDKKSENKNNEKQNISSERKLDTLDSTLDSTDIFLMKKMFEKDYFSKNILLKLLIFCNFSVQDKLKKTFFKSPPIFESFIYESNIDILRFVRILRNEMLINLPRFDLKYKNFNIQNSCFLEQNKEDYQKYRKYFEEIKPVVKSIGINIEEIDEYLSGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L867</accession>
    <name>A0A4Q9L867_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0279p0020</name>
        <name evidence="2" type="ORF">CWI38_0926p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000279">
        <property type="protein sequence ID" value="TBU03536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000926">
        <property type="protein sequence ID" value="TBU12036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L867"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0279p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0926p0010"/>
    <dbReference type="OrthoDB" id="2191249at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="352" mass="40991" checksum="2524173AF9268110" modified="2019-07-31" version="1">MDLEKNENEINFYTENCSSSSLEIFIESDVSTLSNLNTDAIITKKNDQSVLVIPQDISFSIYENIKHFSNIFNRDMYLEKKSDSLELEINSAILRRNNSSNCVKNIELYQNNLKSIKILEINSYNLSGEDIKAFDIFLEGNEITVIDDFISIYNNNIISIYKWDSNIKLSKIKVFKTHLLLFYIKSNLLSKNSRIIFYTIILTLIKQKIKRIDSFLEGILLYLDIDNITDMEIIDEKIIIKYKNSISYSYDLYLNRIDTPNNYNINSINTSSTNNTPNINTKNTNNCTKKDILSQINTSNTTIIVKPDIIEINHKEKSFFENIKVPNAQQCVYTSNYMFLLCDKFIRVLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8S6</accession>
    <name>A0A4Q9L8S6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0178p0020</name>
        <name evidence="3" type="ORF">CWI38_0061p0040</name>
        <name evidence="2" type="ORF">CWI38_0506p0040</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000178">
        <property type="protein sequence ID" value="TBU04143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000506">
        <property type="protein sequence ID" value="TBU13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000061">
        <property type="protein sequence ID" value="TBU20496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8S6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0178p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0061p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0506p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="188" mass="21378" checksum="F629CE1F0BA20591" modified="2019-07-31" version="1">MNTKWTSILLTISKFIICSLNRKTKSIRSVKETNFNESTYIRYETVDDDVEIIPLENDNSSSFYSETKSDNISYSGYVCSSKDPINLSNNCRCQHLTSELYTIFEGKKIESCKDKNEPDKQKFARIRPKSESDLLQSSPWDLIEDFSDASTISDVSNKSVLTDGIIGEQTLETLSPCQSPNSFIYQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8Y2</accession>
    <name>A0A4Q9L8Y2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI37_0173p0010</name>
        <name evidence="12" type="ORF">CWI38_0001p0040</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FI-OER-3-3</strain>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="PITJ01000173">
        <property type="protein sequence ID" value="TBU04177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8Y2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8Y2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0173p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0040"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03356">
        <property type="entry name" value="LbH_G1P_AT_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="246"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU04177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="353" mass="40017" checksum="CEE970FFB613A7F5" modified="2019-07-31" version="1">MAIRTENIKALILVGGYGTRLRPLTLTTPKPLVPFANKPIIQHQIQALKKSGVKEIILAMNFEYEAIIQEVRTYTKQFGVKIHFSLENTALGTAGPVSLASKYLQDCRVFYVLNSDIICEFPLIEMMKNHLESKCEGTILTTVVENPKKYGVITTVENTSLIDSFKEKPEEYFGNRINAGIYIFDVSVLQRLEIKNISMEKEIFPKMANERKLNCYELKGFWMDIGQPKDYLIGQSLYLKYLKIPENTIMNESCKIGEGCKIGPNVVIGNNVTIGNYVCIQNSTIFDGCVIGDGCFINNSIISWECDIGKWCRIEECTVLGHKVVVDDCFSVIKCMVLPFKRINENLFDRILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEE8</accession>
    <name>A0A4Q9LEE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2591p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002591">
        <property type="protein sequence ID" value="TBU06363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2591p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30000" checksum="A0771061CCC26956" modified="2019-07-31" version="1">MLGGCVIIWFDFKCKERFEIKDSGVTWVKKKRGEKGRERGDSYMDCMEVEGVNDRREVVGDKGVLVISIIFKRVLVMSIIFKRVLVISIIFKGCYNKYTNYKGVSKNTIINTLLNIILISNTLLSTTGISNTLLSQTYNYHPLTYPPIYSPLTYPQHPPPTIFIIPLLSSFMNISILKRKITVELIIYIFMFLTVIVLTIIIILLRKYKTKNFLNNKETLYYNIIKNRNIKIEEYEDIVFELPIDDKNYLPRVEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LH39</accession>
    <name>A0A4Q9LH39_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2605p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002605">
        <property type="protein sequence ID" value="TBU06280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LH39"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2605p0010"/>
    <dbReference type="OrthoDB" id="2192717at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="25047" checksum="8430718B4E4443AA" modified="2019-07-31" version="1" fragment="single">EVVRCLHLLLINRYKFKSSKRIRSHSIQEILDNEYAVIRVDIRIKTDFKIRNNRPDIFILDKKKNKITDIEIGITSQDSLQIVETEKLRKYNLLANDLGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVRKNIAETISFNRRRGLESGLNAEENCERASMRTNTPLKEEKREEDGANNLKTKNNTPFISQGRTTLEEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ26</accession>
    <name>A0A4Q9LJ26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2293p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002293">
        <property type="protein sequence ID" value="TBU08198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2293p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="10709" checksum="827C21F22E363FCD" modified="2019-07-31" version="1">MSRRKKVESENIRNKKIKAVNNLENSVGEILMCDVDVAMLSERLPPPPTFHNTTHQAVVARIVHTDAILKGNRLMVVHTILDSVTVICYSSSAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJH2</accession>
    <name>A0A4Q9LJH2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2368p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002368">
        <property type="protein sequence ID" value="TBU07665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJH2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2368p0010"/>
    <dbReference type="OrthoDB" id="2191663at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU07665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="363" mass="41963" checksum="849225E133179888" modified="2019-07-31" version="1">MSSEPYKLIDLCNSNLPFSVVETTIKAIDFVCERCILIKSVSLFLDKNENFDNLNEPAILKTSNFTEIFELNNKKTNLNTSLETARISIKSYKFSLKKEQKNSFIEKLVCFLNPRKIDLDKPNLILELHLTKNIFYLSIKYKDSKRKHFLKYNIPNRLFIGHTTMDNELSIVTANLCHINSKSLVYDPCCGSCGILFSATLFKATVFGSDISYCEMVGTNTLKNNVRTLLKPYNVFSNFKQFNLQQYFLGVFIADIYSVRLNNFDCVVADIPYGIRANAKNSSKNTKSNVNRDLKTENSETFGFIDQIKEISLQLQSGKRTALWVPEWVEKYTEECFNQFKLITRCKQLLNSYSRILFVYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNE7</accession>
    <name>A0A4Q9LNE7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2219p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002219">
        <property type="protein sequence ID" value="TBU08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2219p0020"/>
    <dbReference type="OrthoDB" id="2189602at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="26292" checksum="F541DED24DCF5D08" modified="2019-07-31" version="1">MVSSIYKGEKFIKDYYSLLCKTDISHYYTPTTILRIGKEKDRLDSFTDKHSTIIYKYQKNLERVFVSCMDTINTKEEEFMVCVVGQFVYKDETVRFSHNFIVKEENNNFYILVEVCRFLNEEIVYDKVDSLSNLHDKRTYGYNNFNRYYVNVSCPPHTKKQDIVECFSKYGRIFDVFSKKEGFFKVEFADHSTLKAVQNDGNIIFNNKGFKILPSREDFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPC9</accession>
    <name>A0A4Q9LPC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1849p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001849">
        <property type="protein sequence ID" value="TBU10323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1849p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="67" mass="8467" checksum="DAB02F57A585C545" modified="2019-07-31" version="1" fragment="single">NFFDHRKVFYEKLKNLFEILNKKYSKLFYDDKLINKSQLKTEYLPLGQYRNIDRQPVMSLKRFYYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ95</accession>
    <name>A0A4Q9LQ95_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1928p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001928">
        <property type="protein sequence ID" value="TBU10226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ95"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1928p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="567" mass="66510" checksum="669E2511ABA2422F" modified="2019-07-31" version="1" fragment="single">KITLIEVGITSQDSLQIEYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKYKAPLISQGGTTLEEPTNYINEESDLEEETIVVKECSDLYTKETKNLQQLPNTIDCGIFMFYARLYTYAAVSIANYINNSISKVFDVVFYRPNPSNYEGSKKISYKVFRLNKLNDKFLYVSRYYQLEESTHYATGLGTFSYILLKNDKTLTYFMAIFFQMYKIFGYLARTRDNIHSSYIKIQDITNSKRTKIPKKFEMFQVNTFYSLQHRIFYVKLFAEIYISEKLNISKDKMVQNFNSLFGASKCVFSGSYSYYYIENKRVETKNSGKTNISWKSNVRRNTILIRHELTGFKPLMDLYLLKNVKHTLKESLIEYEYYDEDDITTGKPKKFRVVFRYNSAGFEFNSNCFVDCIVKTYRPDTSIYIIALWNYYFNIVECEREAVDSDKFRISGTRKYNILGNKSLEETQCSTQRVLSIKDFLGELFFNRELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQA3</accession>
    <name>A0A4Q9LQA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1598p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001598">
        <property type="protein sequence ID" value="TBU10703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1598p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="6919" checksum="3B5F9CD1B2589FA3" modified="2019-07-31" version="1">MRSESAYLSVTAARTRNISVVAAMNKYGMIYHKIHERAINDEDLKLYIKEINESCQRQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRG1</accession>
    <name>A0A4Q9LRG1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7769 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1931p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001931">
        <property type="protein sequence ID" value="TBU10221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1931p0010"/>
    <dbReference type="OrthoDB" id="1734867at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056671">
        <property type="entry name" value="DUF7769"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889:SF7">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24964">
        <property type="entry name" value="DUF7769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7769" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10414" checksum="EB36A545F1CF8993" modified="2019-07-31" version="1" fragment="single">MENVEENLLNSEKRDSKYKQLTKEQRQGILEKLLQQMKENKLKCGAINEVSSAFQVSRLTVSRIWHAAQTQYRKGKICADVSSKKKKRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN2</accession>
    <name>A0A4Q9LRN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1389p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001389">
        <property type="protein sequence ID" value="TBU11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1389p0010"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="200" mass="22829" checksum="72E8DFDE00B32E39" modified="2019-07-31" version="1">MKVSKLISVERKVEQRLYDQKIGNTFEGSILGPEYNGYVFEITGGDDRQGFPMRRGVPSSAREIKDIDVDVMDVVVEKVEISVLSVIIVQKGDTEIAGVTDRVESCSHLPKRASKLRERFEIPEGADIKKFLVESITKAAKESGQEKVKIPRIRITGEWTQEKEDAKNAIKKEAEERKKRSKTQREEFFAKYPELQQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSF9</accession>
    <name>A0A4Q9LSF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1410p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001410">
        <property type="protein sequence ID" value="TBU11056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1410p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="358" mass="40735" checksum="DAD50BE263647B79" modified="2019-07-31" version="1">MSRRKKVDSENIRNKKIKAVNNLENSVGELLMCDVDVDNSPVSLVDTIKSSSGTNATACEPANGMSNPNTEAILEGNRLIVLHSILDSVTVVEQEWPRSAILAVQKRFERMPRNGWPAKLRYYNEKFSCTLDIDAIATCVTEPCTLTNTTEFINLIDKFLSKIKEISEKKIAKVVIRTQKLPGELVDSKVSDLINRIICEYAGAHVTEYAISRLSKEKPKSAWKENIESKISKLVLSKDLLEKARKQEKLSTSETKSLKKIIREFNLNLSSVTDLSEALQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIGSFWSTLWNKNDDTVTYDDYLIPFVSDNHPTTFPSLDGFVNILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI1</accession>
    <name>A0A4Q9LSI1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_2235p0010</name>
        <name evidence="13" type="ORF">CWI38_1733p0040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 10"/>
    <dbReference type="EMBL" id="PITJ01002235">
        <property type="protein sequence ID" value="TBT97486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001733">
        <property type="protein sequence ID" value="TBU10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2235p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1733p0040"/>
    <dbReference type="OrthoDB" id="2194859at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBT97486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="199" mass="22725" checksum="C4E840F0B4BBF7F8" modified="2019-07-31" version="1">MAKLYFRYGAVSSAKTLNLLAVSHQYRQQGKAVVVIKPSIDTRFNIKTVRSRAGLETEADIIIHPECNIFDKLKTHKNIFCVLVDESQFFTKEHINQLRDIVDIRDIPVICYGLRTDFKTHLFPAVVRLFEICDVIEEVKSTCSFCNKKSTMNLKSVDGVFVTQGPSIEMGCEEKYLPACYPCFREKTRTGVSETKDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT04</accession>
    <name>A0A4Q9LT04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1076p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001076">
        <property type="protein sequence ID" value="TBU11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1076p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="83" mass="9850" checksum="D051E3FF3639B99F" modified="2019-07-31" version="1">MKLTGIKNKDKRQGLKYGETTIKDEEIKNKDKRQGLKYEETIEDEETIQDEETIQDEGTIQDEETIEDEKTIEDEKTIEDKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC2</accession>
    <name>A0A4Q9LTC2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1542p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001542">
        <property type="protein sequence ID" value="TBU10800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1542p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="724" mass="84479" checksum="64523D7933B8B0F4" modified="2019-07-31" version="1" fragment="single">MPESKAFAKKVEKQLNIKNVQKNNKIKAANDADGVNKSEDMLQNCEQHLRANSLPSSSYPTTTHPPPSQTCSNMQNSGLDTLALPYTPLPSSPSYDMTNLLTRRNSLELFFCRTDKVERMPRNGWTELQLFHNKKFVQCEMVEESKSEQDRERHKFLSKIKQISEKEIGKVMVRTRKHPNELVDSEVLDLVNRIIGEYADSHVILTITDKPRSAWKENIESKISKLLLSKDILEKARKQKKLSFSETKNLKKIMREFNFNLSSVTDLSEAKVKKNGSLNVYEKKIMMHESKKQFRKENRMFEVFQSRFYRELTERVESEHVVSRDEIVSFWSTMWNKNDDTVTYDDYLIQMESNNHPTMFPSLDQFSSIINWLPNWKAARNDGIHDFFIKKLTNLHKYLYDIAKAVCLEVTLQADWFSSGLRSDYRPITFMSNLYNLTIKCATKVVQLENQLGAVRGVLSPLLFVLGMDHLSRMLNEKYTKVKIHNDAYTLSIDLICYTLEAMTDKEKQFEDNLIRNNKNTATNDNCYIRVYKYLGIIEDSKSNRTRNSFDEVQSKLIARVERLLLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLHSVELRSEHMLLQFLDRLEKHKDTSNRRAAILKVENNITHLSLIKGFLKVKYSLVEEVTKKSLEEAQLAKLYNEIEKRKLHLKLYNARKNELVSVSDSSRWLKRGNIRPRNEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC7</accession>
    <name>A0A4Q9LTC7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1057p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001057">
        <property type="protein sequence ID" value="TBU11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1057p0010"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="149"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="536" mass="63377" checksum="DF0C69EF949568D7" modified="2019-07-31" version="1" fragment="single">LLSNLQVIQITDSTFIFDNYKIKYIEHLLIQEFFINRCESEKNDEIFEFINSMPNLKSLKLTPNSNISLFKYVFKYNMMKLKNLEKFKIKDENKCDKGYSDSLYLEKIIELEINCLFEQSFLYTLFLNQKLENLEKIHIYNCNIGLKDKNSRRNYTRIQDILFSNTKLFGISFSERYNDQNDQYTWIFNVIDTYTKHLWCFKLINKTSELVRDSLKFLFNNFGVPVAIQSYNGREFKNTLLEAFLTDLNIKIIHGRPHNSKAQGQVERVNQTIKRWLAKKLHETGFNNPLSRSIIVENEASLIVTAIYIDPDIALVEENAERGLDIGLPTLPWKSYSTDVVMGYKKYEKKDQCYNQECVDVIKNRNLASLKALQEKTEKYAQKFRRARTKASHILKEEKNKKDYKIRKIEKMAENKEIRKRYKTIRNEIRDFQARNMMAESTEWFLLTDPKKHLNSKMQREADDIINEKFMKENNDHIEDGETNVLEPKVAETTDGIIGLANNNTPGEDKLTAKPLKYEGDFSENDFYNLIEELWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP0</accession>
    <name>A0A4Q9LTP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1087p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001087">
        <property type="protein sequence ID" value="TBU11677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1087p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020327846" evidence="1">
        <location>
            <begin position="24"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="562" mass="66632" checksum="FEB99BE45EC0A214" modified="2019-07-31" version="1">MFLSNLNLILFTFIVYNRYNCTTSNIQQSEDTREDLKQYFKDFIEKNDHSVKINEEYTNNNFIIKDSIFGRNLDIKNWLEDEIKSDSYYLICVEATDKLKDENTTLEVLKCLKYTYECFKIIENKNDFFLNTDYNVKGLKDFSALGLSDKKSKIYEMMDIYILKSNSKEVLKNKSTMMLERLDKRNALQNWRLIFVSDHILEANTLLSLNQKIENFISTSDPLIKQFLSFVKKENKSVNMEETDYPQSSSLLPSVVPKHFISNEKFDKQNQKLKIRFEKKDCSEFKDFQKNKLSQYVVYQLTISDMVFDKSIEFLLLFKNEKIEYITSPKCNWINMHDTYYYKTNDFIMKTFRHNIESVIGNNLIDIFGKCINILKFCEAKIMFAEHETVFKEIRMLSAHNNEEVSNKFKNFFENVKKHFKKEELEMEICYKQFCEDTTKKLEAIPFKDFYGLNISSWDICGNSNYEYSKDFDCEFAELITNIGQDIVKIINENVFYNCISSQSNCGMLLRFSKKDESAFELELIFSFKDKILNMTIFSKEYDFDGNADNILGIFNTNWPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU23</accession>
    <name>A0A4Q9LU23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1082p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001082">
        <property type="protein sequence ID" value="TBU11686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1082p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020934179" evidence="1">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="435" mass="50777" checksum="5FC9FC29B96C00D3" modified="2019-07-31" version="1">MFKKILLNIVLIGINIIKSTSLEQRPTSETDVNCYFELLCRIENFGLKVFEKYISIVGNNVRNDCGIFIFDRDTEILELTRFFLVMFPKDKKYMFQSNIFLKNLGKEEIPLGEIAKEAKWVYTATVNEFKSSTYTLSSSKIQDTFEYVEKVEILRHLIEKNTKLQNFDIVDNFCFNRTFSPSLYPCKGKEDNITIILLGLAFLLPHELDVFEFIFEELYRTYNLYGKNIYFAFFPNIKSRHMNEFGRYLTSSDICRYYIFNFYVKNINIPNNYKTSTGIKILNSKKCSLYLTGETFTSENGKELTKKFENLDFDKDLLKHIDVAKIKISKTSLTTTSLNNYHFKFKAKLFNNKSINIVSTTQKLESGLYYVFLLNLCDIDDQKNNISIILHTNLLGTNMKIDKCESSEQITSTGDLLKAIKRKFENVLIWATINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU71</accession>
    <name>A0A4Q9LU71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0831p0020</name>
        <name evidence="1" type="ORF">CWI38_1056p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001056">
        <property type="protein sequence ID" value="TBU11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000831">
        <property type="protein sequence ID" value="TBU12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0831p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1056p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="20202" checksum="A2F6F5DC3D117072" modified="2019-07-31" version="1">MVVIDINEERVVNIVLIFFLKAWWYKKLNKMYLYKAFRLHYLLYNILENSINCTLHRINIVYVSKNELKLEEFEKYKSIESNLKQSVYLNNSFTNLRVKALEIIYKKNLDKYKELNKIEKCKIIIDYPHQCLLKFKTFDTFLNSKTKSFNLYLDELDNGSLNIFIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD5</accession>
    <name>A0A4Q9LUD5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1025p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001025">
        <property type="protein sequence ID" value="TBU11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1025p0010"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="405" mass="46849" checksum="F15C9FC749111768" modified="2019-07-31" version="1">MQKYDIGETVSVGSTGIVKKTKNMNFAIKILTKTDKNKKDVMKEIKIHKSLDHKNIIKFIEDIEDETSYYLVMDLAKNELFDFIEPDIGMDLTLIHFYFKQLIAAITYLHNKGICHRDIKPENILLDNNGNLQLSDFGFSTLFIHKKERRRLFTILGSYTYMAPEILNGSYEGDLVDIWSAGMVLLVMSSGVTPWEKPSTDDKKFDAYIKTKFLNYSPFISLNTEVLKIFKQMCSIDEKQRISLKSLKNIPWFSKKSNLMDENGLCANKEMLYQILYKDKIAPPFSQPEKFKGFTDKFISSQPVCNTFDLPMMKRIYLEESINSAMPKVIKLFESMIVPYELDKIGITFNTVDSKRNTLSGSVSFIKMMDFVCISFTRLRGDCIEFKKFFNFISEKLSIDNSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUD7</accession>
    <name>A0A4Q9LUD7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0827p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000827">
        <property type="protein sequence ID" value="TBU12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0827p0010"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17458" checksum="9BAA351355721C94" modified="2019-07-31" version="1" fragment="single">PAIKSKFPPADKKKIIYVQQDNAKPHFSDNDADIVALGSADDWNIKFKAQPANSPDFNVLDLGFFNSIQSLQHEASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHISKGKLGREGRLLEKYVCSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS6</accession>
    <name>A0A4Q9LUS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0799p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000799">
        <property type="protein sequence ID" value="TBU12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0799p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="192" mass="21320" checksum="A50738FD7DCA4CE6" modified="2019-07-31" version="1">MVVAESVPNSTDIVTFENEASGQGGAWCNRTLVCKNRIEYNIKMNACQSKELHEKESNNDCRIGIPETTKAELSPQKTESLTFSCNIIAEDVISINPFQKTNHINMLSHQRPSIAPNSNTERKISSDNCHASCGENKICDESCNGYWCEPCKLIKCCEDPDFVSGCTEGFCISIRIFLEVIFNTLDVVVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV23</accession>
    <name>A0A4Q9LV23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1187p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001187">
        <property type="protein sequence ID" value="TBU11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1187p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020273039" evidence="1">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="384" mass="46561" checksum="157F92B8793E40B5" modified="2019-07-31" version="1">MIFWTLLCKIILYLSSYRTTHSNVEENKNSICNIYNECKRFIVENNGKSEEGIEGEDEIINLVLLKDDTLRYLSVFNLYSDYISSFSYFVVKIQISVKSKKMDFLFFKKLFNYLKMYILDKNRVRNNVILKIKDFSLPPDPNYMDFVDENDIKILFGCVDGFQSKLRNIYTFKEAFSIDDKIKDVVELVFFFENIPSEWQIEKIFNSYCNFYSKKMVGQKYLMYFSNKLFTPKKLGSKHFLRSLEVLKLEFFRKSEEKTEFNFDENDEKNSEFFLNYQEKLQNKAEYFDIRQTTNKMFFYFERIIKDDDFYGFISKKYHNKYLYILQFGNILSKKRYEVYFVFNKDSYTLEGAVFIDGSVYNNSHQFYQKNTFHRFDLSYFLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV67</accession>
    <name>A0A4Q9LV67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0875p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000875">
        <property type="protein sequence ID" value="TBU12156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0875p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="536" mass="63523" checksum="2AE58A25700DF143" modified="2019-07-31" version="1">MPILARLTDKQKFSFYKISKNGEKSFITEFNTSNLVEDYFINNKGQLFYIMNRSLYSTEGFIKKMDEDRYEWYKGKEKSYLFYISNKILWKIELTIQRNKTGLDSVNSPIFVCEILKDDFYKIIVVSENQIFLFSEKTLISIFNSNLKQQEFPFKINNVKHCLDRLLIIDENFSVHFFMMANNRIEGGFKSICKEVSFLKVSLDGILVFYGKGEIFFVDVKNKRILRREQHIVEDVLILDCKTFYFVNEEGIFRFYIENGKSEIFISGKGEYKIFDFEKPIESKSDGDSSRNESFVEKKIFLNEKKSDETKSGNEEKSFSGENESFVEKSKSPRKMENPTLKNSNIRNENLKKENENFLGNSNISFKQDSFIKNEDLSKNSSVKFQSHFEENFKKNDDFLDSEKSKSKNKETSSINKNSINFNSYNNSELRSNESFIENANSNDFDLNGNSEFRKKEIVFEHTNPNNFNTKNNFDDKNNFDDKNNFKDERFPCGSCKRRIIEIEELRNFMFQMKIEMRREIFALRKEIEKLKKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV94</accession>
    <name>A0A4Q9LV94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1143p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001143">
        <property type="protein sequence ID" value="TBU11555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1143p0020"/>
    <dbReference type="OrthoDB" id="6686792at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="341" mass="40227" checksum="F392C1D4F7F9559D" modified="2019-07-31" version="1">MKVKKLLISLIAMIFVLVIWIIFIISSKRKDIEKVSAEKNRTKVSEDTLLLSERNFVGLENDKYVCYFNSIIQALYVQTDFMNKIFSYKHNQNQKCIILLKEIFSHMLKGQIISTSDYLKQILDLNVDYKSFKFGFSEDAYVCLSIIFTQILNEINDNRRFNISKIIDFKQFQQEFFLGDLYFYRLQYTINCSYCHEKTIKTINDYTFLLYLEFSIQKSIVNCLNLKNIDCICSMSSNIFGSAIKTTEITSLPKNLIIKNSHWPCSNSDVLINEKIFVQNQEYTFNACIFHIKNLHYYTVAIFGNRYYELNDILVKELNIESIENLGYSHLPDILFYKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVM4</accession>
    <name>A0A4Q9LVM4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0639p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000639">
        <property type="protein sequence ID" value="TBU12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVM4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0639p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="38076" checksum="AF17CCB21E5C577B" modified="2019-07-31" version="1" fragment="single">FVFFLVVSILMFLFYFRNKIAYNIVLIDSVRDFLRSEIFDIFMAFTFLYFKSYLFISLSRGIQNLNPEDNIFNSFLTYFLGCWAFLVIVKGTRAFLSFSMYNKITGTTRSRTVKDTIYILGTVYLAALIFPFIFIFKRIKRPRIRESDSKIIYFLKSIYDFPLSVIHFFIKDAIVYDNPLIMIYAAVNNLPYFDAMYDSYKLYVHSNTKRLCDDIKIYECFMPFILLLSATTTYFFNEHQIFKKYTFESSLPIISLFMLCFLELIYTSSQFLVYFYVIKPEELRNMNPELFNIYDRSLTDKRYFNLQESEKYNILSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW47</accession>
    <name>A0A4Q9LW47_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0574p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000574">
        <property type="protein sequence ID" value="TBU12958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0574p0040"/>
    <dbReference type="OrthoDB" id="2192627at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="48482" checksum="D9E3A7BB641DAC53" modified="2019-07-31" version="1">MKRISDYLKKNNKEEKPLSISRQNSLNEKMTNMLNIGQKKDIKNRKIEKENKNMKNNYKEFTGKNLLKVKLPLELAHCVLCKYNKNFGKLLSGRFLMVYKKTNLKSINRRYRETHLILKSSTSFTQKMIGFVNLKVLDVMDINYFNFEFIEDLNLQKLKIKNVKNISIRKNISRYKIKNVKIEEMYINLIELEKIIQINSLIGITIKNVNINGSNNINESLLQSIILKTQLKKLKIIQMKISEEFICKIVNNLHLNVFKFEECNFKFIYCNIITKIPNIFMENCKDILYTLNYSDIKSFKLFDSHIKLIKLEMLNFSDLKEISFNEAKIDQECFDFICKQYTSLEQISFSKCDFPIIKLYDIVRKYTKTLKFLDIRNIEIPIDFLEFVKNNLKNSTVIYSDNKKLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW96</accession>
    <name>A0A4Q9LW96_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0990p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000990">
        <property type="protein sequence ID" value="TBU11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0990p0020"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14570" checksum="0A0267D31794D1AB" modified="2019-07-31" version="1">MMALIAQKYYGIPKEYVKEYEKRLINKTSKLVRYSLKFLFDNIGVPVAIQSDNGQVERVNQTIKRWLAKKLHETGGRSWIEHLNNVISDMMKIDDDLNLVKKEIITWTTTNLKQNKTEYEKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT6</accession>
    <name>A0A4Q9LWT6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1204p0020</name>
        <name evidence="8" type="ORF">CWI38_0494p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001204">
        <property type="protein sequence ID" value="TBT99821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000494">
        <property type="protein sequence ID" value="TBU13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1204p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0494p0020"/>
    <dbReference type="OrthoDB" id="2190497at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="51"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="548" mass="61837" checksum="9C7CBCC7C8C34E17" modified="2019-07-31" version="1">MKENSFDDQIKKKRNIITIFSCIFLGIMFTLLDCLSYGRNMLPKVKDDTSIENISMIIYLYSTITAQIFYGIFTKLESGIMAGAIVESFPYMHSIFNVCKEGNESINSVVTNTLLCLLISTMLVSFWSFLLKKYKIGGFLKMIPKAAITGCLGAIGLSQFSVAYGEICSNIFDSKALLLLSIMVICAFIAFLLQEKFSDVVFIVPLFSLIVISGFYVFFIPILGNSLDNLILNEWLPKKESANLFLNQIWEKLSFKELSAKYVVKNIFNIFLLSLFSLIHMPVNLPAFGTATGVSFNFLDELKTQSIGNFISAFTFCPTYFISSCSIFFNRSGGKGKTESILLGVFLCTLIFFGASLKTYIPRFVLGMIPCFIGISMCYSAFIRIYSEASKYDLLVVYFTAFVSMYFNLVVGLIFGIFLCLLEFAFRYNKITKTGNVSSDLELSNFRNNKFSKSIARIKVDFMLVFATVEKFDKLTHNASTYSVLVLDLMECSCIDWSGSDLLVGFVNGIDSNCKVYIIGKPHNYELYNVQKRFNKEIEHITENIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX71</accession>
    <name>A0A4Q9LX71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0752p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000752">
        <property type="protein sequence ID" value="TBU12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX71"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0752p0030"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="798" mass="95185" checksum="E2B700FD8E128553" modified="2019-07-31" version="1" fragment="single">MRENKKDKITHKKIKKKNKSEIQNLLSEANIFYVKNKLNECIGLLKEIIKKSPQYFQAYYTLGLVYEEKNELENAFNCFYIAAHIKKKDYVLWKKLYEYTFILHDFYIKNGEYNKVEDKFITNERISDTHSFKSNPDLEITSTDRISEIYKERIYFISILQKKYNSPNKIKEKIDLYEILSMKDKILETKLEYIYFYGSGDVKTEGIYEKNSFIEDNFPESNSSENEEFSASNDLNTEFEYNSETNDKIENVSNETNTDFKEELIDQCLLLKEIKNTIKSNSELIRIIRKAIYFSYKCKNKKSISTEFLNSLISFSYELRDFKSLKNAFNNFAPINVKNIFIFFITFISLNRNPKCYFYEKAENIITSNSTMTTYLGNESATFKLENMEDNITNNNYDANRELKNSLDLFFFEKLMIFKESKDFLGFSNFYIIFDLIDTLFKNKNYTLSYEILEVLLQNNFTSHQINIKLEILNRMAGISISRNLKDDGIKFYLEILEILKNKKYFEIYNLKKEFSNEKLEVECFKMANGETKDAHDSNSSFINPMFPFIFNQDRIKAIVSNLYEELGNRDLALQYSLDINDEIGHFVDDLDQSNHEKKNEFSSSECKKIRSLFHKIFFFYIENPNDDLERTLMFINTSNQLISDFMNNSYILNPKKYILQQSLGKVYDSNFEKSRLKSLHGLNVDEWFEVMKMNILCHLKLKKYEDSMNLLNRCLKSGVFKQRSDIYIQFLFLGFKYSLLNNNYGDFVNFVKKIVFYYQNASFYFFMYFFSNFFADYNRDKNFGHCQKNLQRLCKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXE4</accession>
    <name>A0A4Q9LXE4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0200p0010</name>
        <name evidence="3" type="ORF">CWI38_0783p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000200">
        <property type="protein sequence ID" value="TBU03983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000783">
        <property type="protein sequence ID" value="TBU12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXE4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0200p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0783p0020"/>
    <dbReference type="OrthoDB" id="2194817at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445368" evidence="1">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="416" mass="49438" checksum="6E1653BB96C0DB04" modified="2019-07-31" version="1">MLIILFIKLLSSFLNPDLDDSSEHLSEKRVQLKKITEKMPYETEIKDPVTNPDLIIPGLREELLYETILNLNSFLFIIEINNMSDKYLEKIIETVIFIGRNKILNLKKHKNNLKDELWKLFDIFSNFSRKIDLSKDSKLKKALEFRNYYFDRDKSQIAKSLFIEELHELKKNLQKYSSDEILELIEVKDFDTKDFKYSKMIKALRRSIIETQNLSKSIQREKREFIQEFIESNAPISQYNHKKLNEIRMEFNLGGSIFEPNLLFQICSDLILGEKEEVIVKAISKILKPIENLELYLRHKTNTERKEEILKFLYSCLKEQASKFRDEIDDAFRARSELMGKYLEKETEQSIIQKEKSIDKYQENFIQDMISRFSEINEAALTNFMVINKDIVHKYIRFLNTGSTKEKSSLIEHFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXI1</accession>
    <name>A0A4Q9LXI1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative subunit 3 of integrator complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0705p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000705">
        <property type="protein sequence ID" value="TBU12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXI1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXI1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0705p0040"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="191"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="442" mass="53210" checksum="2FDA6C58D3D444A4" modified="2019-07-31" version="1">MLVKNSLDNDELLNSLELCYNTYTDNKNYINLIKTNYKEIIFSSLYEILINPNKESYNRTISLIRDDFSLLFSTLKQIIKLKFHLLKTDVANNLISFVNFLISYERGIEGLVINILRYTNYRTDIQILENLYNFYLENKQYFPKDSVIFSFLIFFCSYNEKYNNLINKNILTEIGRDLLLTQILKQNINVSNNFIKNTLNTPTQKQYLVSKLSPDLELNLIFYIEKGETNTEKYIEWLFNYYITTCEIAVDILRYISSVYYTNTESFQLYILIDKIAEKFGKNILFCLYFDMLYFSEKEVLNNQIPIEYLIYSYKIKNLETFDILLNFLEEPERLACFKKALKETKIDLSIFSDSDQNLKQIFYIKREKDYKYKKIIFYIENMDFQKYYNLICDIKKLGLPFIPLESYDTLIHLSTSWDNYMQVYFWKILCFQKIYLNFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ4</accession>
    <name>A0A4Q9LXZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0704p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000704">
        <property type="protein sequence ID" value="TBU12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0704p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="119" mass="13945" checksum="77932FECC8A145F8" modified="2019-07-31" version="1">MNNLSIYGSYSENSEDFVEFIISLLNLKSMLFRNNINLNVFNPNCSKNKNNLNNLGNLHYIHENEFLNYFPDFFNLKSIRYLIMGYEYKEGSIKKLSLNESLKNIQSLSLDKFKIGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY17</accession>
    <name>A0A4Q9LY17_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0356p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000356">
        <property type="protein sequence ID" value="TBU13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY17"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0356p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="15782" checksum="FD7C0753A7CFB22F" modified="2019-07-31" version="1">MNIQTIDCAANPAPAQTKAPEEPTGQDTAQPPTKGSDLQKKDTTTEEEGTPETKKENDSSDKEPEEDKKKDGKEGVPPSGNKSAAQNGTNGGYSPPPTGNGNVFSGNGPVAKFMYDAAHGGNKKTKAYRGVLLVGGIILVIIIVVLICFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY21</accession>
    <name>A0A4Q9LY21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0621p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000621">
        <property type="protein sequence ID" value="TBU12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0621p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="326" mass="34440" checksum="268DF231D48BADF4" modified="2019-07-31" version="1" fragment="single">PQNASSNRGSPSDSKTSSTQTNSSNSSDSNKSPTDGTDAVSKSLDSSPAQDTSTNNKPDSPKKAEAETKKDDPQSNQKTKENKSGRADSQILSDTLPGKSEKLPNKTQQKNKLDPYNTKRNEHDNQRYDGYGGYGDRGYDGYGRYGDRGYDGYGGYGGYGGYGGRGYDGYGNYGGRGYGGYGGYGGRGYDGYGGYGGRGYDDRGYDGYGGYGDRGYGSRGYGGRGYGGYGGRGYGGYGGRGYEEYGSRGYGGRGYGGRGYGGRGYGGSGYGGSGYGGRGYGGYGGRGYGGYGGRGYEEYGGRDYGELGVYDDLDDFWNFFDFFGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY26</accession>
    <name>A0A4Q9LY26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0155p0020</name>
        <name evidence="8" type="ORF">CWI38_0373p0040</name>
        <name evidence="7" type="ORF">CWI38_2535p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000155">
        <property type="protein sequence ID" value="TBU04304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002535">
        <property type="protein sequence ID" value="TBU06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000373">
        <property type="protein sequence ID" value="TBU13644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY26"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0155p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0373p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2535p0010"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU04304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="247" mass="26659" checksum="ECB95A4F96942898" modified="2019-07-31" version="1">MSKVIRKNRLGRPCNKKNKMFKIAPSIIPSFDTPVTATVKSILHERGRGAPLTLLNYKKDKKYDAVIVSVEGTRTGQNIEMGDNVPLSIGNITRLKNVPEGTLVSSVERIPNDGGKYGRSGGCFVAVVAHNKNTNQTIVRLPSGIKKTVSSEGRAVIGIVAGGGRTEKPILKAGRAYYKYKSRSISWPVVRGVAMNPVDHPHGGGNHQHIGHPSTVSRHAPHGQKVGLIAARRTGLKRGSSKELVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY38</accession>
    <name>A0A4Q9LY38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0347p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000347">
        <property type="protein sequence ID" value="TBU13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0347p0010"/>
    <dbReference type="OrthoDB" id="9856535at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="560" mass="64353" checksum="3A3E28AC94CD308D" modified="2019-07-31" version="1">MHKIINQIEENKISLEKAFSLVKNKPYFIDLYIYRNNITSSIFIPYFDQLSNHSKCLLIPLYLTTFPTSDMFLDKELEIMVIKKYLLRNNTSQVSHINNTLEKPHINNTLEESHIINTSQVSHINNTSQVSHIINTSQESHINNTSQESHINNTSQVYDIINTPRIINNLPSYNLSLNFLLNNFTYKSDLQDRFILTNLILIFKTFKIKPLYTNSSKSTNINTPLVPSNNNTCKYCNNTLTIEETILLSDTVNKHMSNINIPCYERGVIIMGLIIQSIDIKGLKEYKYFSNILNDYWGVIYTDTCNHCKSNKNNNKECDLEGVSYKADSIIDKGVVNYMDGDLEGVSYKADSIIDKGVVNYMDGDLEGVSYKTDSFINKGVSDNTITTLNNTPLYINLSVSKEIRPSYILQAINTLKKRYCELTVKTIPKLLTPSSTYIPLLFKSLIQYLTDNNTSAINVPVIDLITLLHVKYLKIVYPLSLEQLFSNNTSLTDKLIFLQIFFTLVDTVDIIMVKEIYKYFIYKSKGNLYNDTIKETACVFIEKCKTRIYSNSRCNRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY51</accession>
    <name>A0A4Q9LY51_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0608p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000608">
        <property type="protein sequence ID" value="TBU12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY51"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY51"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0608p0030"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020684275" evidence="6">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="504" mass="58636" checksum="4AD1F343778E5828" modified="2019-07-31" version="1">MLLFIHFYSILSEILETCTLPENAPTNIVLKKFYRETCPHCQRLAPLIEEIGVRLERSNTPITIQSVDCGKCECSKEEIDAVPQLILYKNNGEVGRMKGYKEFDEIVTFLTQNTDINPKIFKHRIKKHPGQVVRLRERDFYTGFDGPWVILFYTSKDSHLREILNEVSKIYSEKLNVGEIPSSETQNLTHRFNIQSYPVLLILYNGINMVYNHKMDLPTLSDYVDELLEPSFKELTLDAFNTTIKNRKIGDPIFIVFNTNLSLANSYFRQAAHEYKMKAKIYKTSDPDLFQKANIFPKKEIENTNETKETEHVKDEDMVILAVYRNGIFHQCPEKLTNGYKISEWIFHAHFPHITIINNDNFFTIFHGLKPAVILLTREEELVDQFEKLSANRHIGLPFSEKVYGVINVDDYPLFIPSLVPNLPVPSVFIYNPFRQYFYAQRILLNENNFNDFVEELIEKYDENKLKPYPPKKSYIMSYLMVLGVIIGIGLLLLKKGVATKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY96</accession>
    <name>A0A4Q9LY96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1086p0030</name>
        <name evidence="4" type="ORF">CWI38_0480p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001086">
        <property type="protein sequence ID" value="TBU00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000480">
        <property type="protein sequence ID" value="TBU13277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1086p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0480p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445369" evidence="2">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="182" mass="20283" checksum="073730328EB9D8B9" modified="2019-07-31" version="1">MLHLFVTIIFNGCGIFTSDTPSTTIEEKSHNERGNGKESLVEAETGYTTESILYSNVESSEMKDGKPEKLIGNKTQAQPSSNTTTHKSILIGTIDGTNAANPQKSSKKVRFKDEKLVSIRKDESPTDNNKGSLSAKKNDTMPLTPKSPNPQQKSKPKFNSENEYDKFNQDLKNHMNNFLNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN3</accession>
    <name>A0A4Q9LYN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0606p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000606">
        <property type="protein sequence ID" value="TBU12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0606p0010"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020210762" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="286"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="50089" checksum="1D6E886D516E9DB0" modified="2019-07-31" version="1" fragment="single">MIFFILFFTFLQTETPNIYSYKQINLDNTKDEPLKANFFDCKNTKHEKCDENNILIEHLGRTFTLKPENEKVLPSIISLLNKYKAPPQNIKEIVENLTSLESKEDPEIVSIRSGARSFAIYFVDSNEVDKITPSTLPNISIFLSSDKKLAETLDTPFPGIYGFNASERTHYRMKPTESYLSNIYTILIPILEEVTSETIKHYELCQLPVFYIFVSQKDSESLMKDLKPIFLKYKEKAKGAVVFYKQEKTNLKHFGISEEQLPAMINLTNKKKYKQVGLTKENTENFLENYFSESLTPYEASGEVPEDNSKRNLKVIVRNDYKKYYEDIKKDIIIVFHSPYCRYCVELKPLLEKLADLYNKYASKKIVIGTIDMVDNDMPEFTIHGFPTIYLLKGKTREAILFDQQRSFNNFIEFIHQNGYNKINLNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU2</accession>
    <name>A0A4Q9LYU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0267p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000267">
        <property type="protein sequence ID" value="TBU17865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0267p0010"/>
    <dbReference type="OrthoDB" id="2191694at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="318" mass="37672" checksum="7CD31989A6FA0531" modified="2019-07-31" version="1">MLKEVDWSLLIALACSDKRSEYISFLFNPVFFKNNATEHYEYIHIFIEAAFKNNDYDILLIVTHILVENHKDLIKKEDFLSLYVNLFLSNFSHSVNFTISYRREKLLNFFCENVTDKNTNNLILVILDFLTKHKITTPTKYVFTLIFLYSSRTNDISNETVIKLKDYTFKCIQFHSTILTSEFDKYNEELYFNIISNPHIKLYIVMLSLYMVNFNLKIDFTDEDLISCDHILYIKLIISLICYKRGQFDESYLEDIRKVLLKFIINSRNSHVSTLGMLIKESDKSILIENTEKADILAFYDNILEKLQTCLKKEKCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZA1</accession>
    <name>A0A4Q9LZA1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0518p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000518">
        <property type="protein sequence ID" value="TBU13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZA1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0518p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020717162" evidence="1">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26091" checksum="0F9D369D155089F8" modified="2019-07-31" version="1">MSKLLCATLFFIFEIIKGTNEANIEAQKNESLQRMINEAINDIQDFSDNIETTAIRGVENFEMIDSEETSFVSALNEENFVNVPNNIASTQALNGKNKCGGFFIPGLGFKFIDANSPLFPIHQRISRIRIEIDLFNKIVRDISKRIQQKKLKFAFSDFIINSLKVVGSFSESNIHSFHIFIVKTENILKACGASRIIFSLVLKFAENLCQDFESTIGMLNDNLKMILDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC0</accession>
    <name>A0A4Q9LZC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0513p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0020"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="504" mass="59445" checksum="72CAF6FB8D3C599A" modified="2019-07-31" version="1">MTILEFNDKINTILCKGQGLKSILFDLESSKIISNMVPYSVFLENNFFLFEYIGSDDRSVVRGVCCVVVIRNVSVNLLFKEIKKPLYDEYIIIFTNKIGERVLEELADNDRFGVVKEVYEIYMDVFYQDVGMYTVMPVKYGGDCIERCVDGIYSFLVHLNVKPSIRVIEGRETVKIIGETLKRRFGGEEYKNGGELVIVDRGCDMITPLLYKWRYQGMIYEHLEYKDGLVQFKDKFISVFDDSFFIKNRFLDINSVGENIKRQVKEVEKNKKIKNNEDVCNLEEKSKIVEIAENHLLIYNYLAKECLENKELSELELNIIKNNKITIKEISNICNNKCVNFRKRIKILLIYLIKNDFDFLRNSYQDNLFSSKVVQMFPEFIQIIKRFGEKYIYGDCSDKNGIIKTKKYLPVFLNEYDVKLDYVPGFYTFLESVIKKNLKEKYFPYILKSTKEYKYTIIYFNGGLTYEEYRIFNEFCNKNTKLGNKMFLLCDKIIGYNDIFINII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZH2</accession>
    <name>A0A4Q9LZH2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0356p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000356">
        <property type="protein sequence ID" value="TBU13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0356p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="803" mass="95381" checksum="008607C56D76CD1E" modified="2019-07-31" version="1">MISIRAMYDDKKSVNDFLKYFEKVKDYLNGILLCLCFPKQINRIILTIFLFQNHLYCLKVKFIELTGKEVFNMQKNSDTYFLCVNTGSFMKLQDSLCLESPLAASNSKNDLIILYPNDIKISFDFLDKLILQNKVEVIVYMKSNDFPIFAYFIKILQDYDNIIMQIDPQIFFEILKYLNIFRVKRNKNYNILIKTLVYYSVISNMDFVKDATFLILNHKEYNNLQVRDLIECFLKLILMNKTYIYKMFHKYHPIEFSHILRQHKEHKIKDNFVCIDLVACHLYKRLLKANSLDKWNMMMNIFLIDKLYTNFCVYENELDSETILLLLPKILISFTATIKQAELPLFDKLHQLGFFKTVKNVKIINIGLRFKLFLEKLQYFENVEKLALEFLTVNFEEDMVFIENSVVLKSIKVLKLFFCRSLPLLYKASSIYLSGTKDNIIVDLSSDLEISDIENKYEIFSTYNLYNYLCGIDLNLHKKYYTSTYFSKIFNYKLIKRLKINLKNVKDNCLNCYEFLESFNNLKKLYFENIKLTDKLLKVILNSNHLTSVIFFKFKVFDITKDGIISNFYNESVIYIKLIQLVDTLNSNFFIFLSKFKNLKCLFFNLHILGDSNDKNYFIEDRISKLNISKLKNLENLPLLKCVRYQNNFEIGNKTSFSILRVLSYFFNLENLEELTYSIGCLYTEDIIVFSKFKVLKYLRLSIQKKLSSFDILNEILQLNIKNTIIKLDLVAEKLEKFEIFSILNFKRLKILEIGIFLESGKYKESLESLIGMNLIYFNIYRFLPLPIWLGCGLYKQNIFTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT0</accession>
    <name>A0A4Q9LZT0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0191p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000191">
        <property type="protein sequence ID" value="TBU19829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0191p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="15480" checksum="1DE7D1DAAEE90DBC" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEVQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU1</accession>
    <name>A0A4Q9LZU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative subunit 3 of anaphase-promoting complex</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative subunit of anaphase-promoting complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0295p0020</name>
        <name evidence="5" type="ORF">CWI38_0465p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000295">
        <property type="protein sequence ID" value="TBU03432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000465">
        <property type="protein sequence ID" value="TBU13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0295p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0465p0030"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU03432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="516" mass="60108" checksum="C4D7678AB410EDFF" modified="2019-07-31" version="1">MITFESKILLLRKYKSYYNAIFLTSALLQTNPNYITILGILYYESGQFSQALNILQSLSTTTSKYYESLCLYNLREYSKAIEILQNLISNNFKLDTPFNSEFDSLILPVNPEIVSELLGMLLTLNGEREKSLSYFQKAFYTSELPYSFQELLSENKFSDITKELKGFSDCFSNESSNKIFFANNICRKYFEHRLYLKTGSNIKNSKLVNSMVKKYSKFFPGLGSFFLAEVAKDVFESGLTELSQKLFEELRRRDHTAIQNMDVFSTVLWHSKDISGLGILCRELIRSNPMSYATWTSLGNYFSFKGDHHRATLCFKRSIFISKNYYAYTLLGHECILKNEYQLALRNFLGSCKMFIHNFNAAFGCGMVYSKTDKIDNAEFFFKKAIAFNSKNTLLRLLILQFYNRCSLYGRIVENIRDIFLGQKEYDSRDLGIILKEIFPVMISKFKSTETNELILLEMVDVLLHYQMEEEAKTIIDMVKTRGRIYFSKKTLIDNRKNDNKKEDFDSTTFFSDEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU3</accession>
    <name>A0A4Q9LZU3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0289p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000289">
        <property type="protein sequence ID" value="TBU17013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0289p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="719" mass="86307" checksum="7BD850D4CDA2E2C1" modified="2019-07-31" version="1">MEINNNTKCDTLLYQKDLYFLCMKTCSLVSNFEGREFHYDDSCDSHNSMTTFNFIYPNQISLGFDLLDEKILLNKEEIFIGIEKNCFMLFSYFIKFLEAEDNIFSIEPNLTFEILKYLNIFRIKRNHLYMNFIKSLTFHSVMFKEEAFSEKTAEIFLDYSEYNNLFILDMIEYFCKFYFLPKYFIDKTFHKYSPNRLFFRRKLHKKRSIFRNMQIEGIELEIYKYFLNSRFRSIWQILIKIFYLDKLYLDLYTRFNDTNMDIIVSSLPPKPKKITLLVEESHLPIFDKLHKINYFKSKKTVKLIVACDTKYILERIEAFKNQEKLILIFNKIEMKELVCLESSPTFESIKYVKIRFIILTEILSKVASASFQGNRKNIYIDFSENFKISDSENNLYELPTYNFKDYIIGISLKLCKQNYELIDFKKLFHPEYITRLNLDLKNVENNSLSNYFFLESFKALSTLYLSNIKLTGELLKFILRSKELIFVWFKYFVFDENLTCENLDFINKSVIHMEFYDITHHLNIQYYYFITRFIALRYLLVCLSYSPDVAFKSFLIEDNMIDASISRLKKPVLLPNLCCFKYTNEVMYQNSSKFSSLHIFSFFVCFDFLEKLVYDADALHLDDIDIIENIKTLKCLKLCVFKIDIEFNILEKILRSNIRKTVSKLQLYVNEFTSSELFSILSFKNLKFLRISAMNFEERNKKYIDLLTGMNLINFVAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY7</accession>
    <name>A0A4Q9LZY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0174p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0030"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="441" mass="52118" checksum="C1460C291FC19C71" modified="2019-07-31" version="1">MKVKYSFILSAVYKLFRTLIFCTNLEEFPNLIEINSNGNRIEYTVENRECIMKSENCRFAFDHNMNTKYIVRRIPFCDITEDTLNEISYLTTLNYDSIVKFCGQVKINDYNYFVCEYPGQDLKTILKTRNVTYEEFLLIIKQILDFINYLKAKNIALFNLNYRNILVTESWKIKIHDFSKVIKENTNLENIEEAMCHELSTLFGSLPPEVTDRKEFNHKTAVWFLGKVLGECVKIKKFNNSITDNNLKNLSNLILYFTVNDMENRPSADIALLHPSFDFLYDFMICFGSLSDFSFSKDGNSIVKKKKILFYNTTNYSYTIYCCCNQNKSIEFTYLKQTLPNIFVNSTTTPYISKLLNYKIQINTIVYPLQHLNIKNYNEIKDLFTLIANKNLLKEKKETIHKQVLLSFFQKHYHVIIVVSIVIILFIASIIIYLKKRRYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M032</accession>
    <name>A0A4Q9M032_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NrS-1 polymerase-like helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0397p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000397">
        <property type="protein sequence ID" value="TBU13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M032"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M032"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0397p0010"/>
    <dbReference type="OrthoDB" id="2375545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="NrS-1_pol-like_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NrS-1 polymerase-like helicase" evidence="1">
        <location>
            <begin position="715"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="988" mass="114571" checksum="7DBA2A4A3DB97E28" modified="2019-07-31" version="1">MKTIKKTNEEPGSEFELETVIDEWHEENLVFGYTTSIFGKRMTISGKDNFLELYKREIPKGYFNEFIRANAKVVLFFDLHSKEFQLDSLVDDIKRFVKGYFSGFDIQFIVSDATGKEKFSKHMIVRLFKEGKEYVFMNVSEVLSFVREHLNLPGVDLNVYKPGGCLLRAFGASKEKVGRKLVFDAKHTGLRKELDLIEHFVQWPGELGECIRTFISKQSFSCFKEESLVCNNQAITKVEGRTSDSKNSLFLKLLEWFHFKSKKIYRPRESEVKDGMLVIYVDVEPLDVCPYNVMHKSNKTYLRITVVNAVLKCHGCRLKSKNHLFEVKLEDVLNKEEIYILFRGNILQKQLLNNTHHLFLSKDPKAGLPIYNGSENSVRSKVGSPEQVKEFLGIESINMDTYHNLTASSYSVVSQDKSIELSFPKEKHITACQKELKRFSKNNVEVNIYQTFKSTTTINNIVVVDKNMNSVACLDEMYDKPNYIEIVYDEGYFLKSKLELDLDCEDSFLRIFMDSPTPVFFARFLTVVLGGRAIVVGDNLYVANINNIYKEYSKEATLGILAYLSEQFLKGLDGSRKLLKAQHANKDCKDRLFSKYRTMRLRLQSPRFLKSTMSVLFPFIRNEEKGLKFNTKFKLLPLKKGVFDSELRRIRETQLDDYISITLPFTEQDLLFSDHKKVAYLFLDNIFKNECEIEYVLNELRIILFDDSNDKVYFLIGEGASGKKTFINMLRIALKNLVGDLPVKALSNSKTLGMNRFFVNLRNCRIGVVAEYGAQILRVDIIKRLAKYERITVGSLYANPVTFPFKTRLLFVGKNLPKFSAVVDYALERRMKYIYFAKNLSIKENIKNHLELSNESVRHAIGLGLLQLILKEPINKELQIPTTFLRYLSYAFGELKAFVKFLENVIQEATDGYITFFEVYCMYHELDTEHTSKDVCRKPEYSTKFTEFKSYVKAKFNLDESHTRSADRKSIRVFKNLKIVSDNLNEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0V9</accession>
    <name>A0A4Q9M0V9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0198p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000198">
        <property type="protein sequence ID" value="TBU19807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0V9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0V9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0198p0060"/>
    <dbReference type="OrthoDB" id="2189189at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="572" mass="67841" checksum="C3F4DD036AC5B026" modified="2019-07-31" version="1">MNFFRKQIKKETFDLELQLEIISNRLETSQYIEDKLDALKQIYEISLVDPFKVGITCMQKLVSSIPILTSTNLQGDILLKIFKSSNGKEFLDMFMHKEENIKIIGNAFTERKGIFLEILEILIHSDNIKVASIIYKMPDLVFSIVKSLKHSNISFLVPLLKGNEHLRRSIVFEGIFEELIEISETSDDYLLINIFNSLICLLTECHSNQNYFIELKINRILEIWMKRNAMAFDVYMALLDISNSNFKKIQSNFENDYFINLAFIRHRYDFIYRIFYKNISIIKYYLEEKIETLKLFDVYYELENKYQKNYLFDLLVTFFTYKNIKIKIIENDCKYNFYCHVFQNLKEIETTENAIDKDSVDSLILELISEEKLSEFLFDIYKVKESSKLFNLSYFVFINLIREFITPEKPLLAFFIEFLHDCDKSLEEKGICVLFLLEIKINISEIRKNEEYLISCLLTARKLFCNIERDSCIYFREEIINFIISRINYQLKNIFQYKDCNSLRTDYINTGVSQIKQEDPIKKEQTNPTSPDVSSPKETNRFYTFFSNVSSAFVRNAPKNNDKNSNSNVYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M110</accession>
    <name>A0A4Q9M110_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0094p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000094">
        <property type="protein sequence ID" value="TBU20295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0094p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020730689" evidence="2">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="563" mass="66254" checksum="C1892DFF609E2BAC" modified="2019-07-31" version="1">MWYVIYIQLIFLWNFLKSSGIYPTHTGQRRCDIPPLYPPFNGFNQQTRVFPTHFGLNQQFLPVHPFIPNGAQGYQDPSYGSPHYPFQMVFSQTGCVGAPPYDPNPASIRMSHVRYYENFPPSGTNTHIPPKITHSKKQMKNEKPAVSKKHNTNVRKEKSRKITIQEIHKYTVTNENNKCLLEVDSKEVCDIIKSVYEGTYSQELKHYYPIIQKKPKITFNMRWCANEIRNITEGINNAINNLSEEIENFSDLFETFKSYAYSIFYTKNNYPMIYLKPIFLIIPIWLEDKIEMDLFEKKNIFYISWCLSLIQALMEHNKIPFELIDPNFEEMQLEFSKQFENKSARIYAHFNYISEFVEKIFVMNNNSEDLFYIFSRVSGVGFLAQKCDIVFSEEFTSAKMPSIIFDIFILLSEESLKTLKELIMGYEYKKEIQPHQRLKFAKYMKINLNACNYDRNNNIRTLYFDVARCYEKIFSNKNFVDIFANSMVNTYFSTWLAENISNLESKISEKKFPQFVDILGFIEACSVLLNYISKVVLCPNLVPAQYKDILARKLTKCLGKQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M129</accession>
    <name>A0A4Q9M129_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0301p0040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000301">
        <property type="protein sequence ID" value="TBU15977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M129"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M129"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0301p0040"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU15977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="212" mass="24183" checksum="935104889E4A7C48" modified="2019-07-31" version="1" fragment="single">MKKEFFELQKKLEENNIPECPTFIPKELRGENIKNQYENLYKSVLYNVSKNHSNFPVLSDYIGVDKLCSCQNQLNNKKFTNNEFKKANNQNIENTDSSTNNSVQNKKLKETNSKENTQNQAIYDRIRSEILEGTVSIKWEDIIGLESVKKTINEIVVWPMIRPDIFKGLREPSKGMLLFGPPGNGKTMIGKCIASQCKATFFSISASSLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M131</accession>
    <name>A0A4Q9M131_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0079p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000079">
        <property type="protein sequence ID" value="TBU20384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M131"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0079p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="51320" checksum="58BF7ED102BE2A1C" modified="2019-07-31" version="1" fragment="single">NHPLFIDDLNLLAKDISILSAITDEAKEFLKLYDAMRAVLVKNTTNLHLGCQERLYLRRIEFGRDLIIVQNNKKIHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIKKRRLHSKLYNARKNELVSVIDSSRWPRNEAVFCYIQDRKILWGADGMCQHCGKSGKTVDHLATRCEKMLGYDYTRRHNEVVRCLHLLLLNIYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRSDIFILDKKKNKITHIEVGITSQNSLQIVETEKLRKYDLLTNELSLIYKCSVEIIPYVMIWDGIVTKYHKSHLKRLEIPMNVEAYIQSLVLKKTVETISFDRLKGLESGLNAEESWERASMGVIMRAEMHKEPTPPLKEEKKEEDGAKNFKPKNKAPLISQGGTTLEELTNNINKESDLEEETEVVKEVEENIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M144</accession>
    <name>A0A4Q9M144_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0294p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M144"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="75" mass="9384" checksum="952B34A2900BAC7A" modified="2019-07-31" version="1">MENFHLDILDRRGDLYRTSIQVRLEAYIQSIVLKKTVEVIFFDRRRELQSRPNTSESWEMVNWMYYIYKRYMNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M148</accession>
    <name>A0A4Q9M148_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0074p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000074">
        <property type="protein sequence ID" value="TBU20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M148"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0074p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21595" checksum="253098F928B42969" modified="2019-07-31" version="1">MCQHCNKSDKTVDHLATRCEKMLGHDYTRGHNEVVRCIHLLLLNRYKFKSSKRIRSFSIQEILDNEYAEIRVDTRIKTDYDLLANELGLIYKCSVEIIPYVMTWDEIPMNVEAYIQSIVIKKTVEMISFDRRRGLEDGRASMGVIMGAEMHKYVKQVNSKNILPLILDDVTRPEEPTIDINISRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1J8</accession>
    <name>A0A4Q9M1J8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0601p0010</name>
        <name evidence="3" type="ORF">CWI38_0251p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000601">
        <property type="protein sequence ID" value="TBU01909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000251">
        <property type="protein sequence ID" value="TBU18154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1J8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1J8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0601p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0251p0030"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="237" mass="26462" checksum="C48C382D72301ED0" modified="2019-07-31" version="1">MNHELDHSFTVFSSEGKLKQCDHALQAALNGSLSAGASAFNGCVLSSLKNLPLLVRSELIWKVNSICPTIGITYAGLQPDYRILYDKAVRMVEVYKDAYGRYPYLDVFVHNFCLKIQEYTQKGGLRPFGVMILICGPILQNDTIKPALYQIDTSGSFQMLKVGSVGKDSDNARKFVERRLESVDDNIFNCVGAIREFAGFSIGPTNVDIGVYFSDKNVFKVYSREEVNEVFDSILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M4</accession>
    <name>A0A4Q9M1M4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0043p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000043">
        <property type="protein sequence ID" value="TBU20624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0043p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="539" mass="63982" checksum="6DE6D0533DBEC7BA" modified="2019-07-31" version="1">MGSSKELVNFDHLYDLIMDAQNNYEPLNRSILFLTKNWSDVLQFRQIKYTNFYYYRHSIEVIKNQIISQSDIIMNENILSLENEQTKNWIVLLFSILIRIFRIIQIKNDDSFIIENKFLSIAFGEKYLAYCSDLQKILIPIASLKEIRFVTENQIKFVFTFDGNGTVILYDKITDKININSDKGRLLLTNRENFELLVKNRCLYIDMNNALSMRLLALKILFLRENNLANKNRISHKEIFKLLSKHKESPGFKLIDMSSVIIYSTCFSQKEKNFRNILSILNEYAHRINDIENIHIYFFIEDITYFISLIQRDSSYEMNICSLLAQNIIIFLKKKNSLNLKFTLLFFKILHKLCGKLYLDKHITDLHDDLFAISCYHITYLLDSIRFYKTYEIHPDYDLSNHIEALSLCFNIFTINNIHLSNFTEVSRLNNKFIDIVSVKALIGKWEDNICIILFEFQEKMYPEIANEIIFQKYFDIYNYFINRKYFDSSLISTIFLIISNIIHHKSCDLQIFAKKKKNIVQISTILRLDVIRINIMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M219</accession>
    <name>A0A4Q9M219_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0246p0020</name>
        <name evidence="11" type="ORF">CWI38_0248p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000248">
        <property type="protein sequence ID" value="TBU18231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000246">
        <property type="protein sequence ID" value="TBU18334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M219"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M219"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0246p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0248p0020"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU18231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU18334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="443" mass="51400" checksum="09F7A135AA595235" modified="2019-07-31" version="1">MKSGFQYNDPIAFVSQMSNKSLENLLTNPIFSVSLLKIFDDYTVQFIFDLLTQTANIFKLPNTKEVSTTLKSLKTVNLIEKKGKNIFLNDIFRKSLLIGFSTIELNNIFTETTIDENKFTPDTINEIETNSTNKYNNLLRSIVEQPKVFHNEINISNKCNNILRSSSDQPKFFQNEIIKNLIVFIGLVDKNNNITNKGFEFSLKTTKEQLWILILYGIKYISKSQEEEVNFIFSIFELSMKNASKFYKLEKKSNLSSFLKILYGLGLCEIYDNNIIYLCKSIDILFKSYKDTKNTFLIIETNFKLYAYTNDRYQISLISLFSNIEIILPGLVVGIITEESLSVAFDKGITAQQITHFLQSNAKNNYFSETVKEQIFIWETKKERITSVDSYLYSGFLNLSDFQKVLNFCKQRNYLIEMDENKRLIVGKLDGHADIKNFIKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M226</accession>
    <name>A0A4Q9M226_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0145p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000145">
        <property type="protein sequence ID" value="TBU20028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M226"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0145p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="141" mass="16204" checksum="F374218706393F02" modified="2019-07-31" version="1" fragment="single">LANELGLIYKFSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIHSIVLKKTSGLNAEESWERASMGVIMRSEMHEEPIPPLKESKTEEDGEKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E3</accession>
    <name>A0A4Q9M2E3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0015p0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0130"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14052" checksum="0AA552997C9F0E1A" modified="2019-07-31" version="1" fragment="single">KYHKSHLKRLEIPTNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEKPIPPLKEAKREEDGVKTLKPKNNTPLISQEGTTLEEPNNNIKKMVKEVEENIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K4</accession>
    <name>A0A4Q9M2K4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0207p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000207">
        <property type="protein sequence ID" value="TBU19509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2K4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0207p0010"/>
    <dbReference type="OrthoDB" id="2190704at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="639" mass="74100" checksum="42BCDCD2EB88C3CD" modified="2019-07-31" version="1" fragment="single">LKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISIGPEKIMSKKIDRGILQGDSLSPLLFVLCMDPLSRKLNEKYTKVTIKTDAESHATNHLLFIDDLKLLAEDGQTLEEMTEEVKKFMNNIGLEINKEKSATNDPCCEDTATLLEGIGFYKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRLNARNLFQAINQHAISLLNYHISVHRLEPADFSKLDDAVRAVLVKNKILLRPGCKERLYLPRKELGRGLHSVELKSEHMLLQLLDCLEKHKDTSTRRAAILKVKNNNKTHLSLIKNFLKIKYGLEEEVTKKKLEEAQLANLYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRSRNEAVFCYIQDRNVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHNEVVRFQEILDNEYAEIRVDTRIKTDVKIWCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELSLIYKCNVEIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLNNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L1</accession>
    <name>A0A4Q9M2L1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone-fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0074p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000074">
        <property type="protein sequence ID" value="TBU20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0074p0050"/>
    <dbReference type="OrthoDB" id="2189721at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031498">
        <property type="entry name" value="Bromo_TP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17027">
        <property type="entry name" value="Bromo_TP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="244" mass="28312" checksum="06CAD5567F51577B" modified="2019-07-31" version="1">MKSRFTNKILKLAVAEILIQSSFERCSNSALTILTDIAGDYIMALTKRISSLNILNPESGEDTLIKELISEIMGSSDSYSVLELQTFLETQNNAVTYLKDKLKPKSIDSLLNMLRIVPKIDFLQSQSEFTNSLSEIKYVSVNTEIKVDDFLSDFIQRSANKKEVKKTQIFYEQRFDKPIVNKIYNNNYNKCDRNDSNPEYLKVLEFYQNRFLENQNLNHFDFSLLCESNNFNDVQNIKKFENNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L5</accession>
    <name>A0A4Q9M2L5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0105p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000105">
        <property type="protein sequence ID" value="TBU20248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2L5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0105p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="397" mass="45737" checksum="4A3E1D9C17F5EFA7" modified="2019-07-31" version="1">MQKNFKKACIKNNGKGCEIRRCIGINVYKILLDMGGLFSRHNKSCKKIDHLATQCEKRLGRDYTRLHNLMVRCPHLLLLNRLSSVKRACGDTRIETDVKIWNNRPDIFILHKSNKKITLIEIRIISKILLQMFDLLDNELDFVSKYYLNSWHKRLQILMNIETYIQSIVFKKTLGTQPFNSVIERAKSQEEPTLSLKNASNKEDGVKHFKIKNNTPLNFRWKNHISGTDDKHKEKLDYKTKNIELENAVYMNGEKDNPETKQDNKSVEAEKQGSDVASSSSASKMSDSKNKEFPKVENVEIKTAQVEKERVEKKPTIVTLEEVNYYNENINDLKPKAGEKTSPFVIFLNSKFKEIVAKNRRIRSAKIGLAIVSIFVLGAIGLVGGYFLFKFIQNSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N7</accession>
    <name>A0A4Q9M2N7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0004p0100</name>
        <name evidence="1" type="ORF">CWI38_0006p0030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000006">
        <property type="protein sequence ID" value="TBU20965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000004">
        <property type="protein sequence ID" value="TBU21003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0004p0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0006p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="776" mass="92016" checksum="2ED497E42DD57B55" modified="2019-07-31" version="1">MSIMFHIILSSTKVNFFVINEENSIPCLIDSDLNLEMIFLENKSVVFIGKEDKITHYKNNILRYESSLFQPKYYNPNILILSYENNMLLNSKLIRKLFDTKNTNIRIFLKNVSYSSVLLFLKLIDNLDNIVGQINIKDFLDILMIITALDIEKSKRRDCFFQALLRNVMFEMQNPNLTFNFEEYFETCAYNITKSIFIDLWISFINFVLFNDKTAQRFIVLAENTDLVFKNVELFSNTYISTGKDSNDKIYIRLDHISLEKMFKIVPIRYQINTLIFLFKITNLDILYFVLNTDEASEKAALLFSDITFHTEKLYIGSLNYVDKLFFTKKVDVFSKKCKVLKIFKSESSYNAAQLKKLLGLCKNMTKITLKMDSLDFKRLKILVRFLIKNPNITCKVFCQIYELLHTNVRFLQTIPRNFKIYAGKFQIEKSDAELPIECLPFMHYYCSFYNHDVDTIFPRKFINLECWNFKVFELDFGYNTSPFEIDDSIFSSLRCMHTIKYIYFKNIAINDKLLLYILESKIITSVSVSKFSCSYNLNFLRKCETKNQKLKYFSLKNSLSYVDSDLCSYMKRLGSVASLKFRDIDMFRCYTFNLKKLYEYISANLKTETKKICLKCIEIQTASNDDHSVDYLNILSEVYEFSKLWKIIYNVGMIREIEYHIFNEMKALKYLSIYSRHKWGFINFKKLFNVEMFKTTIFLTIQTDIIKKEDIEVFKKFKNLGILALVCQNIDYETVNSIKRNDFKTTKLIIRKPDRPNRSNEINNYLDSEFNTDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3D6</accession>
    <name>A0A4Q9M3D6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0134p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000134">
        <property type="protein sequence ID" value="TBU20091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3D6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0134p0060"/>
    <dbReference type="OrthoDB" id="2189795at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="35269" checksum="4C9109D1EF42D1CE" modified="2019-07-31" version="1">MSEIIKTIKLLKRSYKQPIIFHILHSHLSFIISKDKRFVLYDYYDDWTKLLILSASDLKFSVYNLEKKIINFLVENRNTKYFDELILFKLKIILYYILNTQQKSTNMFILFELMNNYVDTSEETDYYIFSCVSKHVMCNIFGIKLFKFVQKDAINIFLEKCLKNNSNFLLKSRILPAFIDSNIIPVSFIDFNSDDSLLNLKIFESLCLYAKFTANPSNFKEIIPSSPEFIEIFSLFISKEISDQSTEIKEYNFKEYNLNECLLNNNSLIPFLKNLYNKTEDKDKFISDLKGFIDSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3F1</accession>
    <name>A0A4Q9M3F1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0029p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000029">
        <property type="protein sequence ID" value="TBU20727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3F1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3F1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0029p0030"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="191"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="344" mass="37801" checksum="6B8EA8638399D599" modified="2019-07-31" version="1">MQFKVSIVGGGNFGTAIAKLLAENVLNLKSYSPEITMWLYEEYINEIPLTQIINTTHINTKYLPDIHLPTNIRATSDLKELNDSDILIFVIPHQFVKNIINQIKGTLKKGVISVSLIKGVIYSNGDIGLISKYISNTLNIPCGVLMGANIAIEVAKGYISEGTLSGVNDKEGIIIRNLFNSNIYRVSIVDDLWGVELCGTLKNVVSLGYGICKGMGCGLNTCCAVLRNGLVEICNFYKLLGKGKDCTLFESCGISDLMVSCLAGRNFKAGEFIGKKISLEEIKEKMGGQQLQGPDTAKEIYEYLKGKGKENEFPLFTTVYRVCFENELPDAIYCCISPKSISDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3L4</accession>
    <name>A0A4Q9M3L4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0045p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000045">
        <property type="protein sequence ID" value="TBU20608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3L4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3L4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0045p0020"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="27809" checksum="1D37E11D6CEE32CC" modified="2019-07-31" version="1">MSAFMVKDTVLIDWHRFNNKVTLFESFLIKMAEINSCVTEEMTTFVSRLGNAVCMPDKPIMFYERLDKTKEITKLSEKYISFKLFLENFNILKHLESMPIFLCSTSYSIEEKNDYLLEYLIKLDTRVRTPFIFIFTTKKIVDFPNLKNIFITSQFFDYNDYINLLRCADLGVNMHDIWMDYPMKCIDYISCKLPFIGANELENIERIINSDQCSIKQHETTETFQIPSEIMKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3X1</accession>
    <name>A0A4Q9M3X1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0031p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3X1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="32153" checksum="C71477263D59B19E" modified="2019-07-31" version="1">MNTSQNIRPLNRESRSKKGTVNPAYFFIKNLIFPLTTSLIIFLTEKFYIKSHSVINYVKIIFFQFYIFVFIFLHQNVKKIIENSRIFSFPIIFFNLFFTIYSILNIVFDKKIEKYSVLFLTINKPGILISLFLLVIVVVFCCSSYLFSIFVGLTFERDYVFRNSTIYLVFLIHSFICICGETFFIYYCFLKYYNFTHILPRIVVICFVIIAFIISIYKLLKGRKDVIMSNFKKLIYLLLTIFGIVVYFIMVFSISPRLLRTLDLLDDAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M438</accession>
    <name>A0A4Q9M438_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0228p0010</name>
        <name evidence="3" type="ORF">CWI38_0079p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000228">
        <property type="protein sequence ID" value="TBU03813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000079">
        <property type="protein sequence ID" value="TBU20381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M438"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0228p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0079p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036120567" description="Spindle pole body component" evidence="1">
        <location>
            <begin position="21"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="78676" checksum="8A2C69DC8CD7DCCE" modified="2019-07-31" version="1">MLRNTYYLFFLLYFVFSSRYHDDMNSHFFKRINENDDYRPMIEYNTEVLNSPNVIPLKHLVKSESRDPDIFSYQEASSLSIGSIHETTRMLPSENQFSIHDEESYLISRNCLSAMKPISDRDEMIKETNNRYFPYNRKEIDQKNRDYYSHNTHFSSVRKYTLEGYEDCRRTEGHVCDLYSRPRRYDRDMRYKSHKNNKSVNKLHIMEDVSSRYTRFPRRYLNFESPFVFMKSPEAYIPQLELKNHRNTEVYHPRLQSFSRMIDTRGKNYGILVRLQTEFIGFSDITFFVENDFSIDGYFLENEYHSFFDLIDHIFIMEKTFWSQFDSLTMLKYLSEKMHESLLKYDFCNINSPLLSYFPCLINVKYFLKNIIFEDINLVKSSCLWILLLKAANSLCNVQPNRVPNDRINVGEVTVEKYKDFDVYNGDKASFCVLKRLYVVFYRIARKIFRISNISREYISMLDYMFNNAMYRSKDIHISRGCHLNFSRAVADCMFRIDPKMISLFILGLEAQKIANIKDHDSLLDINCFLLRIFEGSCHLDIDVFSNFRLFYQNLIESYIDFFEIELLSLYVFRGNSIVKNQLNYIDLIVQILKSKAILLSRYRIETLMEISEALCVIFNHFIKVGLNYELYTKRYIEYSVNYCKGKIEALLRIIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M470</accession>
    <name>A0A4Q9M470_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0073p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000073">
        <property type="protein sequence ID" value="TBU20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0073p0030"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="97070" checksum="0CF976AE570FFCDA" modified="2019-07-31" version="1">MYFFLRSRHFCSTFPVRNIEIQSSRSKMFMVMFRCLIVDLYGFCFLNAVYSATLSNNGRIEFALIDWNWIEAITREDLAAAKYWLARQNENSVLDFCPGNHFFRNNRIYPEFFVCPHGLSFLYHKPLHILEVNYRDDWKVRFRVLNYFLSKNSNEPFLFYRSSFGISYPLFSSFVKYLTCDSFDSPNDLSYELFYKFIKILDVLDPISSDFLSEFYYKLYKDGLMNSISVDIINDSENYRLRFFNEKKRRRPFMYFFGVLNDFLDACLIPNISTLSIFKKKNQSIDQCFRYTGEVDRLVLKISACSLDFLMPSLAENAHIFNWLLSVTEISGFYFDNTEFTFNPINFKNVCGFMPPEIPKKSSDPLQTVPSDFFIILNDDNQRRMQYLRFVNVDICFDIFETLLYKTNISYFEVSYCSVDECHKITELLEQMPKLNVFILHGVGIRPDDLDRILFSKIEILILVGCIFESDSVWISKESPDFVYKIMKNLRTLNVSASKLPIDFLHILLHSFNLENLNISRFEFLPANSSFSPIGLRKNRYSLQLDKYIPNKYLEMFSRTYFANFLSLCDSFIFSDIVFFFNIGDLIDSVKFLDLSDNLFPVEFLTLIDNFKNLKKIKLSASLPSSTVGLPNLGMFETVMALDVSRNDINATNYDFVSKFKGLKSLSLANCKLENKLLKKIMTKDMCATLISLDLSGVDLCFLDFKNIVCCKKLKILYFQISNDHPLSYYCDYLELTSAKLNLNVLKVEIKGGVCFDDLVSLAGFSNLSEVKITCSTFIKTGEENFIRFDPKISNFRLELCLKYYNLDIDTLNILDEMFENCSISIVSPHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4J3</accession>
    <name>A0A4Q9M4J3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0062p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000062">
        <property type="protein sequence ID" value="TBU20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4J3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0062p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="58" mass="6934" checksum="3FF38F7D8994687C" modified="2019-07-31" version="1">MFCNSRYKFNLERKCSLVNNPRNLLLGFFNSLLKNVHEIKQYLNFMVVESFKLAKFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Y7</accession>
    <name>A0A4Q9M4Y7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0019p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Y7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="870" mass="101050" checksum="AABE28F380E04814" modified="2019-07-31" version="1">MFCKKLLLILENSLGDEKTQKLYEFCKYLTKRCLGLNVIGLISSFLFLLEMNHCIRIIVDFNALDNPEFLATKRPYSFTPPNSYNEDLNHETAAAFYQNSQCSSKIASNYSGNNTQHHEYDEYKKILKLDTKFESKCQQSNYSATSFHTSNYLNSKTTTIESNIVHLMFHNIGNNEDLDCTKNQVAENTLVHQKSNNLVTFDYLQTFKIRSKYFEELAKTENEQIRLNIKDITKSNVDSLIFEECINVLKNGWNLDFLSIKEEEFLIIIWLLYDLICYAESNALFILYKNLLPFIFLYLTDASFFDELNFFNVDFVNHYKYFLPFIYVLYDTIHVTYNSIVKELVFIEKEQVTTDISLETHDIDEIIIRITPRALELIINENFEKKLILLNHIVCSYTIKGIRISRDNIFFTEIKDLDLACNPFHENTSLKMQTSFSVVFNNINLIDKSLITSIEFEKIKISDIDFNFCMALRNLKSLILVHCDIEKSNFFFRSLSKNFPKLRALRIIGSILTNGFFQNLSLESLNILDLSCCEYKSDLKFYKCPEMKYLQEFHINYSKMNYKIINSMMLSAELKVLSMRGVDFYRLKYFENCDNWKDTFEYLDLSRCMLNNFFLDFFSANIIAEILILDHLCGITHLKRILSQKSLQRSTKKLSLSGSLVDADLLSVISGFGILESLNISALEENTNTLLNSNYNYLNNFVSLNPKRNKLENASLSFINQFNRLAELDISDVCLKAGFMAYICLPCLIISLIKIDISGNLLCPSDIFQIGLLINLRHLVIFLDNEVFSEFLKIYGNLRCLNLETLILCSTTINKDVKNLIISQPLLKKVELRKCIIESNIFTINCSSEPVFFENKTFIVSGESLDFTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M568</accession>
    <name>A0A4Q9M568_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0011p0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M568"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0130"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15647" checksum="FE226A2B0DD9F0C1" modified="2019-07-31" version="1">MKLGVDSIRYEEMTNVACFYYEKIKIYTDPNLYSFLLYFTTLICSIVYADGTEDLKKYRPELLFILITFGKIFEMYKIPRNFKAVLQNIVWEYNSNYLRSWIDNEDNIMQNQATEIFQALANSFYVLDSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5T8</accession>
    <name>A0A4Q9M5T8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0007p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5T8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="93101" checksum="D12E423E2202A2BF" modified="2019-07-31" version="1">MHIGKKNSDIFHILICFFYISMVLDFSTAYKYTYVFKRNKNSEILFFEEKTEKMQVNKEIFEDIEFKILLCSDSNNITSKNPIFIYTKENFIEFEILNNFLYINSAKNQHSCGVIECNFELPYILKLTKDITEITNKPTTYTFISLLTFLSRMKAAKNKKVRKLLQELMFINFFHQNIYPLKNNDLNFDFIFKSGFFTGIDISTKINLISGFLNIFMIKFTFYDDNLILLDNSNEYYDTSLFNEHIPYKNLLINNNKVFYDLENILQKTYILNIFQILLNILDINSLILNNNIGFKFSNIDFQFLIPLLANFMSISISNFTKYSSFLFLEKISKVINDDICYLSLRNILVWENTLLQLLRKESLKGLVLQDVRTIENVNTIENYTISNKNLDYIEYSSVKLNIILWNNYFQTAKFRKIILSFYTSKAQEFFVQEFSNFRSYLELLYFKVKFFTFKLSVEFCEVLVNLTNLKTLRLNGYISYVNTESFLLNAIGNMVKLEYLHIQQPFFSVKNNHILFKIQKLKTLILENVFLQNETPFIHFFNNYKFFIKLALIRVKICLLDLEEILKLENLLDLSIELCKIEHIRYLPKPQYIIPRNIISLYFSDTNLEIMNYLEFLSNLDNLEKLYISNCNLIAGCIGKLSLMCNKILKTLSYQFGTLNSKDLNRIEKFEVLQELDLYRCTFQRCSFHNLGSNCKFFNSLKSLDLFNVNINIEDLEYFMKFKNLKKISLKLSGLDLLKIKHFLVSLPIYQVIINDIRNEILYKKIRKYLHEENIDILQDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M608</accession>
    <name>A0A4Q9M608_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0003p0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M608"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0110"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="208"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="375" mass="43537" checksum="0B8B6ABF2ABD7C00" modified="2019-07-31" version="1">MSNSFSVKNTNENKYDFHVGETPECIECKNDNCLKRLVETPGSHDENLLLTTIPTLRKQMVSINDRKGTIEKPLEAYSMSAIASMYRINYQTVNSIVRRYLKTGLVFVEKSGSDKRSKLTLEIKESLQTYVDLNVRKTLYELAEWVKCTFNVDVSTSTIDRALRKFHYTLKRVTLLPVRRNILSKIELRTNYEASFRELEVDNDDKNFVFLDEVGFSVVTRPSRGRNMRGESAYLSVTAARSRNISVVAAMNKYGMIYHKIHERAVNGEDFKLFIKEIYESCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVLSPHLRILICEKFNEITGEHCSSFYRKMLGYSQKAEVRQVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JTS3</accession>
    <name>A0A4V2JTS3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2291p0020</name>
        <name evidence="2" type="ORF">CWI38_2736p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002291">
        <property type="protein sequence ID" value="TBT97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002736">
        <property type="protein sequence ID" value="TBU05627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JTS3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2291p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2736p0010"/>
    <dbReference type="OrthoDB" id="2195211at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="126" mass="15092" checksum="F4F157FBBCD06214" modified="2019-07-31" version="1">MNNNIIYEISKYVDTSILIPNKKIYECINSKEIRCRRIEMNKNVLKKKMELRQSLFILKFKNILRDRKDVIDFNKIHNIICKVINDKPKNHQNFSVKISRNLSSIGKELNFLLKKVILNAQLKFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWE7</accession>
    <name>A0A4V2JWE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2372p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002372">
        <property type="protein sequence ID" value="TBU07642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2372p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="914" mass="104219" checksum="B82F37B65818642B" modified="2019-07-31" version="1" fragment="single">HPFNFTTTYNPLNHSNSPISLPKDCSINNTCKYLLENILLLQNYKEQDILFFVIQQTLKTMTDINVLERGVINRIIHFKDTHYFIPINDSRRGCYNRRESKCKDSRCYCKEIIKGCYNTDSKGSYNTDTKGCYRTDTKGCYYTNSKGSYNTDSKGSYNTDSNSKRCYCRDIAKIPFNNIIPNLLNIILSLLYNNTLYSYYNLLSYGTLLNPNISMFYTYIGIKVLYNSGLLKGNGGGGNGLDGVGGVNNKSDDYKGVRDKSMVGGVNNKDSSYKGVNNRDSNIKGLNTTNTIHPVNNTINPTLNTLIDLLYNMSFSLDRKVVKYIGLMNYVLGVKIIDDNIVYRCYNTINDVYGVIRIVEIIIREGNDYKGNEDSDIKGVILERECCSNIKGVNNKSTLEGVNKSMLEGVNNMDCNLKGVSDMGSNLKGVNNTSYKQPPFNNTPYNYHPFNNTPGNYNHLNTPSSSLSPFYDKLAFLYFKIQDYYSLKGVSNMININMKMFYDLCLERKYLYAYKVLKYVKDSNLQSDIEEISKELEKWSNKGGVSNKGSILKGVKYNDSNIKGVNARGSNYNPFNNNTSNYNPFNNTNTHHPFINNNTHHPFINSTIDTLNTNTLYSKELLHLIGDIHILKETNNITPLIIRRSLDNNNPILIDYSINLINSYISNIGGVSNMSCNLKGVSNMGCNLKGVSNSSSKLKGVSNISSNLKGVSNMSSNQHPFNNNTNNYHPFNYQSSNQHPLNKTLYEQHPLKNTLYEQNPLNNTLYEQHPFNKLSSNITPPYLLTSYLSYLKVLRLKHLRLNKQYDLFNEEIVEELLNNNFIVLYEQSKYYLTINRKRKALECINRLISILEGVNYKDSNYMGDNYRDSKQQGVNYRDTKQQGVNISTNKQDPVNNSTDKQDPVNISTNTYYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWW9</accession>
    <name>A0A4V2JWW9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2137p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002137">
        <property type="protein sequence ID" value="TBU09572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWW9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2137p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15533" checksum="F49C5C097B816D26" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX36</accession>
    <name>A0A4V2JX36_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1857p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001857">
        <property type="protein sequence ID" value="TBU10312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX36"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1857p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="36461" checksum="BA0B7539BBA55C00" modified="2019-07-31" version="1">MLLQLLDSLKKHKDTSTRRAAILKLENNNKTHLSQIKNFLKIKYGLEEEVPKKKSEEAQVANLYNEIKTQKLHSKLYSARNNELVSMCQHCNQSRKTVDHLATRCEKILCHDYTRRHNEVIRCIHLLLLNKYKSHSVQEILDNESAEIRVDIRIKTDVKIRNKRPDIFILDKKKNRITRIEPMKYDLLANELSLIYKPLDGIVKKYYKRYVKRLQIFMNVEAYIQSIVLKKKVETISFDRRRGIESGPSAEESWERASLSVIIGAEMHKQPTPSLKELKNEEDSEPSINANEELKLKEEIEVIEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX86</accession>
    <name>A0A4V2JX86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1475p0010</name>
        <name evidence="2" type="ORF">CWI38_1519p0020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001519">
        <property type="protein sequence ID" value="TBU10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001475">
        <property type="protein sequence ID" value="TBU10921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1475p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1519p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036125280" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="11536" checksum="991CF780ABEB14F4" modified="2019-07-31" version="1">MNLFTVFLIQNTLCAGISNPMLDMDPNPVHYTVIHLQFIEDESNLYVPLALDPVHISIINRYQDVMDDISLALPYAKAILEVDLEITKFIFEDAIKEAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC4</accession>
    <name>A0A4V2JXC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA replication licensing factor Mcm8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1289p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001289">
        <property type="protein sequence ID" value="TBU11272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1289p0010"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="161" mass="18929" checksum="6ED9C18653DA7944" modified="2019-07-31" version="1" fragment="single">MHPHISSWDLYFDKDEFTFFNTNYETIIKFIRTLRNNVTNKILIIKERGIYKISMRFLVKIISKNQIYEQPENTIKCIACAVSEIIYNEYDIKMYVGIRITNYNIVSSFGVSVSKVEHLVSLIGTVCRVGCKKLIFKKVFFECLKCKEILEIKIVSNVYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG5</accession>
    <name>A0A4V2JXG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1053p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001053">
        <property type="protein sequence ID" value="TBU11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1053p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="17131" checksum="9210915F0841BBE7" modified="2019-07-31" version="1">MKAQESNDNLVSKIDEDLFMKLHFVSSDFRKLINENFIFLNYICSLIYLTKKNCEIHIFFSDFKQYKSGNCLKQKDFLVSRYKKFSQDLKSNCNNSDEDESKLLAEINLRFKNEYKMIFEITMRGMLNSKEDFTFDNKIIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN4</accession>
    <name>A0A4V2JXN4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0744p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000744">
        <property type="protein sequence ID" value="TBU12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0744p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="109" mass="13196" checksum="DAF92A61C2BC221B" modified="2019-07-31" version="1">MFVLNKSRDEITIIQEEITYQDSLQKVLKQNLKHYYLLANDSGLIFMYSLETIYILEECDKNILKYYKKYWNIQQLHISVKACFSSIISRRLSNPFTWIYGDDLNYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ0</accession>
    <name>A0A4V2JXQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Myb-like DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0682p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000682">
        <property type="protein sequence ID" value="TBU12652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0682p0030"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20496" checksum="1D2ACABA95D6E3B1" modified="2019-07-31" version="1">MDPKLSHFLNNDNFKEERKRKIKKEEVKVEIKEMSVSLPDKEQESPDILTIRENKIVIDHSATFTVKENTENFQVTNDTDKIITSLTYSKRVPAGRWLKNESDTFFDALSICGTDFTMINRFLPSKTRKQIKNKFLNEEKKNPHKIAAALNKHSTYNPNDFKRLSKFNIEDKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU7</accession>
    <name>A0A4V2JXU7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LSM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0515p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000515">
        <property type="protein sequence ID" value="TBU13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0515p0020"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="804"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="875" mass="102248" checksum="7756E90AA6A48109" modified="2019-07-31" version="1">MMKTTPKDLSDLTNQYVKITVTKNRNFIGKLVGYDVHMNVVISDVTLPSKETRNLYTVIPNLEHNTSQSVEFVPLPAENHAAESTVINNNIKHSIDSILNTPDDRHSIRNNFRKCVLPQNTISGRFQPYVIPRNLPYAYMNRNFFNKDSVSQPSILNTPNNFYANEMHSPHFNFVYRYPWSVNNIYPFHEISKDYIEIPQRASSIPQTNKISNMLANKTTSTTNFSPQYNHHIQKNSNFQRDTNKDRYLESGISARGTLNCNEFVTPVVSHMNKNNSCTTSIKEPFRMSEAINIVQTTQDMMQSKGIAQKEPKDSVPTHVKYVSTADNSQYITTFEESQNKKGNLKRHNEYSREFSMTRFKITRNDILEKLKLMQMEYEYMLRSLLVIEECAISDEDKKSKKILYEGITEYVLAETNFTEQMKTKILDLIFGTIDDVFQHMFQTVEISTQKIESRLVRLSYSVNELENLYSDEINKIKISEIEIQDILKTCSTFVDYEKQIFGDLNISTIQESLKIPRITETLSRIKECMKNNMIYEILKFLELYEVNLQHHIKNNHLVSTIYLLNVLIIQLEKIDFVKFYHNYDKKTYGERKYVMCVKVFFIGTIFENILRSLNNHDTKANCYGILNVCRTILSIVSFNKKRGSLLSLQLPCLIAMVLEEAFEFDKKQLKEFVIFLFYLMKKTVHTEPDFYDDKIQYFLQINISIIETIVNTTVSFTNEYKDSSYCNNKVDRIRIDCQMILENESDSSKKGNEICRKLKRLYISQLYYTIISRRKSSTNVSLDNNNNTIFNLYFLYPFLMMKTTPKDLSDLTNQYVKITVTKNRNFIGKLVGYDVHMNVVISDVTLPSKETRNLYTVIRGDTIETITPFQEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY09</accession>
    <name>A0A4V2JY09_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0317p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000317">
        <property type="protein sequence ID" value="TBU15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0317p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="91" mass="10660" checksum="48F81BFFA370593E" modified="2019-07-31" version="1">MKESHLKKVEISKNNEEYIQFIVLKKTVETISFNLRRGPERSLSVILGAEMHKQPKPFLKQRSNQEDVLNIIKQKNYTIPNSKQGITLEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY41</accession>
    <name>A0A4V2JY41_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0240p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000240">
        <property type="protein sequence ID" value="TBU18502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY41"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0240p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="21193" checksum="58BFE3F5F884729C" modified="2019-07-31" version="1">MLKKESVRPCDEALLCYVQDKNIFRGAEDVDHHSNTSSKTLYHVATRSEKNLSHDYTIRHNEVRYDLLANELDLIYKLTYAKRLQIPRNIEAYIQSIVLKETPGLNAEKSWKRASFRTTSKPFKAMNNDENGVKHDNMKNIAPPIILDGEDSDLEEEKEAVKMCSNYDMSLCIDAKSYNSNDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY87</accession>
    <name>A0A4V2JY87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0115p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000115">
        <property type="protein sequence ID" value="TBU20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0115p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="32744" checksum="915AAD5A73AD3AF6" modified="2019-07-31" version="1">MKILVNYHITVLRLITTDFFELDDALRAVLVKNLIHTRLGIKKRLYHFRKELGKDFTVKEISTRRAEIHKVENTKKNTLLYRMFHKSELLSVCYFSRWLKKENIRPHIVCQHCGNDRCKKMLDNGYIKGNMQGLDANHLVREILENEYADIKDLLVNELDLIYRGNVDIIPYVLTWNVGLKAEDSQEKALMGVFERAEKHEEQTYFLKQACKIRMVLMKWEQKIFYPYFRRRNHFIGIDDNYQSMLILEKKTTVVKEVRKTHKNCENILTSNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY97</accession>
    <name>A0A4V2JY97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0095p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000095">
        <property type="protein sequence ID" value="TBU20293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0095p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29721" checksum="8EB0EABBD44FA803" modified="2019-07-31" version="1">MIFDPEISFKNVIDLPDKILVFNHSRNWPRLISTANTKLKLSGKLPKISCIEDQNTILKEKVMIFSQLEHDYHIKSFWRFKNICSEISHSDEPNKIIYFYSIMTFKTDFILECATSCTSSLSSELIAKEYYVRHIITTYASIESLEFRKEIIIDFSLEPDQFLITFFLKENTQFEKKFALDFSLYLSNESFEISSDHNLNITNIVDKVNKFEKDNYEFSFETASIDDYKKICVALVKEFTTRMILKKLSIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE8</accession>
    <name>A0A4V2JYE8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0019p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000019">
        <property type="protein sequence ID" value="TBU20823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0019p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="864" mass="100362" checksum="22EFFC4ACE21A59F" modified="2019-07-31" version="1">MYSKKILQILYDFINNKKSKEIYEMCKYLVQYGTRDHYLKVVIIISTLFRVNICIRIIVDFQALDPVIDSISEHPNNSKSIYSYDGQGDNQTESRPCAPNMSSIPEIKKRLRNFKRTDDSNVPFKKRKLDIIDDLKNKNLGSQTLNLNISEVISSESDMIEKNVKEFAFSIDKNEDNLKIFENINILLSEDPIDIVKFDYPGNFMILSKHFDDLQKTGSYEIKLNIKDITKSNIECVIFKECINVLKNGWNNNFNDLNKEEVLDLIWLLDDLSCYSEADTLLLFYRNLLPFIFSYLKDKSYNDVSNLTCTDFISHKKYFLPFIYLLYDSIRVNYNSKNNELTLIEKKHNESIFSFEKHNIDEILIRTTPRALELINQENSKEKSVLLDCIVGSYRIKGIRISGSNTYFTETKDLDFSCNNITKDSTVYEMNTSFISIFSAIEAFKKEEITYIEFERIVVSDKDFSFLKTLKNLESLVLVKCKTPKKKIFLGKLSSYFPKLKNLHIVGYLLQNEIFNELNVMNIVSLELSCCGYRISTVKIKPFKMNVLKEFRMNYSSLNYKIIKPMMLSNSLRVIDMRGVDFLRLLNFEVCENWQKCFHSIDLSKCSLNVILLRYFSSDIKAEILILDRFCNKSHLEIILSQKTLHSSTKKLSLSHNLIDNYILFNVSQFEILECLNMSYLINYSINLSCLEYKLKSKLKDINLSGNRFEKEFLISISQFKTLSKLNISNCNLNSGFMINLCVGSLIASLKKINISENTLCASDIFRLSLFLNLKHLVVSLDSKVISEFIEEYGTLRCQNLETLELINTNVNDGIKNLIISQPLLKNVKLRNCRIELNLLILNCNLSPKSFKKGHIRDTKISGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVC9</accession>
    <name>A0A4V6MVC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5101 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0379p0030</name>
        <name evidence="3" type="ORF">CWI38_0997p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000379">
        <property type="protein sequence ID" value="TBU02982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000997">
        <property type="protein sequence ID" value="TBU11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0379p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0997p0020"/>
    <dbReference type="OrthoDB" id="2186985at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031492">
        <property type="entry name" value="DUF5101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17031">
        <property type="entry name" value="DUF5101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="106" mass="12554" checksum="FC1B294CD7A36055" modified="2019-07-31" version="1">MKFVLKDKTNSKENAEMNLKKKEVKNEEKQKVLNVMRNVYETTRDYSFKYDLGKCIEIIEGKENQEVCELKVALIDALEENELLFDEKCKLIVENDYLKDILKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KUE5</accession>
    <name>A0A4Q9KUE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_2025p0010</name>
        <name evidence="3" type="ORF">CWI38_0286p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002025">
        <property type="protein sequence ID" value="TBT97880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000286">
        <property type="protein sequence ID" value="TBU17600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KUE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2025p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0286p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT97880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="276" mass="33155" checksum="68FBA4EAB2CAB73E" modified="2019-07-31" version="1">MKHIFIAVRIIDNIFEEKLHLRKSLLPIFYIIFDISRIILKLVRPALIQEDGCHIFDRNKRRWNIITVIYRIIGIKRKDPFMTLEIFRKIGDIRSNGNDLTKKIFVSIKNIQLIFRSLLLFVFIISRMFFDFNLIFILIKYLYLINIDYRLIFIEILLMEIIIFSSRIELKLIISVISFVRKCDDILIFSNTLFRNTNVLLRILFKAQTLAYQKTALENITFYDITFFILKIIKKKIDIIIFLNKILKTVLEIINDINTNLMHLEQFLKSSYKLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L101</accession>
    <name>A0A4Q9L101_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0937p0020</name>
        <name evidence="3" type="ORF">CWI38_0877p0030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000937">
        <property type="protein sequence ID" value="TBU00655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000877">
        <property type="protein sequence ID" value="TBU12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L101"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0937p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0877p0030"/>
    <dbReference type="OrthoDB" id="10660151at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="321" mass="36571" checksum="29B44D1BB66EC6B9" modified="2019-07-31" version="1">MNQIFIKCFLGQIMSLLLSTAVVSTHYLKSKIEISPFALLGLAYIVIHIFSQIIYYLSKTKYKINNKNILYIIVIGMTDFIGGFCLIKGLMKMSSYLGILIAQMVYPMSVFTDAFILKQSKVDFKMLSIFMAFVSVCFVVNYKADESDLKFDFIGMCLVLLSDILYMANGTIQSLIIPSIGVYNVLRYFTIVSFIFGAVMTKILDKEMIWNLKELGNFYVSNFNNVFSYIFAFCSYYLMASEYIGKYGIFAFNASIMSYSIYFGILTMIIDLKIRYVVAIGGPLCIIINVILVMKSKDPRKEVSKKVGDIFDKKINFNCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L550</accession>
    <name>A0A4Q9L550_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0432p0030</name>
        <name evidence="10" type="ORF">CWI38_0350p0030</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000432">
        <property type="protein sequence ID" value="TBU02687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000350">
        <property type="protein sequence ID" value="TBU13729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L550"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0432p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0350p0030"/>
    <dbReference type="OrthoDB" id="2196240at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="19"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU02687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU13729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="408" mass="44744" checksum="80D149F60CC43DB8" modified="2019-07-31" version="1">MKDSGSENKESINASLIYSTVLSCSGSWLFGLNMTSLDSLSEVFKNGSESIEDGLFKSHVKVTDSEWSIIVSIICIGALASNFLVNLIPLSRKNILILNNILYLSGFSMIFCVQNIFYLILGRFLIGMGAGVACAVVPLYLGEISPDKIRGLISSAHQFFIIFGVLGGQILSFLFSTVHTWRITISILIAISILSFIFLFFIQNPVMKNSAEENVSIAQLFAEKKARKSLFLSTIIHMGQQLTGINGVLFFSNEILAATGKARLYTISIGLVSLASTTVSMFTVDMFGRKIMLLLSCLVVSTGLSILGSGHVPVISLFIFISGFAIGLGPVAWFVTSEVYPSEYKSAGNAIAVSSNWMSSFFVALTFPFFYTWIGNFVFFIYATIIMTLFLLLLVMFKETKGKKADFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9R1</accession>
    <name>A0A4Q9L9R1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0172p0010</name>
        <name evidence="3" type="ORF">CWI38_0224p0070</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000172">
        <property type="protein sequence ID" value="TBU04186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000224">
        <property type="protein sequence ID" value="TBU18887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9R1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0172p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0224p0070"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="217" mass="25380" checksum="941B5D70A468AC69" modified="2019-07-31" version="1">MNTMNLEPLINFFFIFFPIVGYLPQIITLQSVFPPLLSTITIIANLLKIFYYKVNKYEKPILYQSFVVIGVHSFLLYFYNKKLSYLEEKIFKHKNLNRIYQKYGLFTLNMILITFIALTLNCLCFINGMENLFIGCGFLSLTFESLVGVIQIVINKVDNKKLPIGIKKQRCGKELFFCWFFGDLSRFVWMIWLKSPVLLVLSVVFQIGIDLALIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9X4</accession>
    <name>A0A4Q9L9X4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0119p0010</name>
        <name evidence="11" type="ORF">CWI38_0604p0040</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="PITJ01000119">
        <property type="protein sequence ID" value="TBU04557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000604">
        <property type="protein sequence ID" value="TBU12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9X4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9X4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0119p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0604p0040"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU04557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="522" mass="59757" checksum="5A0D979FC2506519" modified="2019-07-31" version="1">MKPSKSIQELIEEKNEERHLKLTRKIQIGDEFIYIDYTRTHVDEGSLKPIYDNMKGIEDKIDDMFTGKKINFTEDRKVLHTALRDKDLIRKLSGEFPDLELTKECTEIYKEFMSMKKFSDKFNNGELLGITGEKIDTVVNIGIGGSDLGPKMACHALNFYKKGNTKVYFISNIDGTDTKLVFDNIDPKKTLFIVVSKTFTTLETISNGNLALNMMKDALKLPEKDIAQHHFVAVSSNLDEVKKFGIKNVFGMWDYVGGRYSVWSTVGLILCLYIGFDNFLEFLKGASIMDEHFKSVKKNENIPILHAVIEIFYNHRLHYNNKCIVPYDQYLSTLPSYLQQAEMESNGKSITKNNEKVERTCFIIWGGTGTDAQHSFFQLSHQGTRETLYEFLMPLSPLNDYKCGNVSHHQMLISNCLAQSRALAIGKKSKTNLHRNFTGNRPSITMCYSKLTPKTLGALISLYEHKIFIQGIYWNINSFDQFGVELGKTMAKEILKDIEEKKHDDNDSATKEILDLVKILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAG3</accession>
    <name>A0A4Q9LAG3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0090p0020</name>
        <name evidence="2" type="ORF">CWI38_0244p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000090">
        <property type="protein sequence ID" value="TBU04769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000244">
        <property type="protein sequence ID" value="TBU18374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAG3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0090p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0244p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="99" mass="11361" checksum="2BC249042E0C1E1C" modified="2019-07-31" version="1">MEEERIKTYLKTKYGDSTKVFLPEANNKKEVTIKHMKDGTIIKCIKTPGHSLYSKCFFVKLNDNSKAYTAVGNLFSFLGCNVSHIFSKEMYVKSLNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LD38</accession>
    <name>A0A4Q9LD38_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitosis protein Dim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0011p0080</name>
        <name evidence="7" type="ORF">CWI38_0957p0040</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000957">
        <property type="protein sequence ID" value="TBU11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LD38"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LD38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0957p0040"/>
    <dbReference type="OrthoDB" id="2188851at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="145" mass="17330" checksum="E519620FFE1D6D45" modified="2019-07-31" version="1">MENSILELKNSSEINQKIKNENKKLVVINFGHTDTFLYQHYNEIFKDLKFKLSLFIDFYNCQIPNVRELIQNLDLYDDVNIMCFYRQKHIKIDFSTGNNTKINFYIKSKEELIDIFTLMFKEAVKGKNIVLIPTDHTYNKFSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFR5</accession>
    <name>A0A4Q9LFR5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2567p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002567">
        <property type="protein sequence ID" value="TBU06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2567p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15091" checksum="526DDF0509C5D8DD" modified="2019-07-31" version="1">MGRKKNVSSEISKNTKIKAENDADEVKKSDSEVQKCKLHPPAISLSFSSYTTITPPPPSQTCSKMQNSELDILPSPNTPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRMIFDSVTADPKEWPRIVFLQYSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHS6</accession>
    <name>A0A4Q9LHS6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2386p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002386">
        <property type="protein sequence ID" value="TBU07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHS6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2386p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="22515" checksum="9A8151F131E959DF" modified="2019-07-31" version="1">MVNGFFVVVICGVKRLWCCQNENQCFSVVSGLYWVDCDFVGGFCFCGLWCGFEWNFCNFSCFFCSFLDFLSRDMGYSNIKYYSGRVCCVDRVWCVDIVVRIVVVSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDSSSKDICLISKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIC3</accession>
    <name>A0A4Q9LIC3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_1917p0020</name>
        <name evidence="11" type="ORF">CWI38_2332p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01001917">
        <property type="protein sequence ID" value="TBT98075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002332">
        <property type="protein sequence ID" value="TBU07919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIC3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1917p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2332p0010"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT98075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU07919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="219" mass="25762" checksum="8E4A38C35CDCD210" modified="2019-07-31" version="1">MDIKKLFKESSIVQKKKQSKTKKFIPIVQYQKKITFCIEILNNNNLMKEKELKSLSNQLKTIYSVNKRTIYPVNLVFSNYEQIREYMPVDSEKWNILKINESLFLDFSYKEKCLSLFGVENVVFLSSDAPTSLECIEEHTLYVIGGLVDKNRHKGYSYNIFTNLNIPCYKLPIKENIKIFSSTTLATNHVFEIFADFLVTNDWKETLTNKIPKRKQMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKP6</accession>
    <name>A0A4Q9LKP6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2333p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002333">
        <property type="protein sequence ID" value="TBU07911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2333p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="272" mass="31396" checksum="85F2CEB945D2BCB2" modified="2019-07-31" version="1" fragment="single">MFKYFFKILSFDIKECFNSLLEHIPGNSKQHDDGLNEKDSDEISLNFDSFSLEKEIKEHVGSETESRYYRDEQFGNLSTDNCEMEAYPCGLLEIDKIVATEIELHTANNTIYTSKGNNCLGVSSKDQSTTVDTNKYTEINILVVEKTDGKQKTNGNRPEVGFLWNYPISYSNSSKETKPLQNLEKHENFLEFHESRIPSNQLNNTRPEIDESEPQINISQRRKRKRKIDSDVSSVNIRSAKEYIQNLLEEIEKVNSGNINEDNLSDDLRNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLZ6</accession>
    <name>A0A4Q9LLZ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0259p0020</name>
        <name evidence="4" type="ORF">CWI38_2295p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000259">
        <property type="protein sequence ID" value="TBU03652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002295">
        <property type="protein sequence ID" value="TBU08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0259p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2295p0010"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="383" mass="44888" checksum="46B30DA736BBC0B2" modified="2019-07-31" version="1">MQFRMRNGENINENNTNRKLNYSMFPNGSNKKIFSQQGIVSSNPFFDRRILHNHFNERFINKRIIPNKWYDFFPGRIVNNETIRNLNERTKPTTCNSFKLKDEADLLLDFSRSISIEKKFKVESNSNINVDYLNCKSELANSEYFKSVPESPNLNIFHISDNDQSVCNPNLKDDIAYERLDLPNDGLSNIKSKLLNENKEVDHFNEYSDENKNTSTRVFWRKSSIISPDMIVSRKNSEVKAIQIPHRENNIIKNTKPEEAISAIPKPNKTKLIEMFNWIQKYDPIYKANSMAKKYLAFLIKNIDVYTNRRKRSKQENLSSEDKKNNHVESEHHRRDAINLGLYALSEIIPGPVSKSKKSVILNAIHYIMKSRYENSYFSKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LND4</accession>
    <name>A0A4Q9LND4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2095p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002095">
        <property type="protein sequence ID" value="TBU09899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LND4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2095p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020670245" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="153" mass="17673" checksum="1AB67AB14E5224C1" modified="2019-07-31" version="1">MILEMVLNTYIISLLCLHDFIYCTSDVSNETENSGNEYKEISSKNYCLDSQEHAYSPEGFKNDTKTIYFQCNSYQSQEIRQNRSFPQSFKSLIKKLRENENDCCDSSQKHVLHTSIKSIEKNKALNPIVKISKLKNPKSSSISDSSNIKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPD4</accession>
    <name>A0A4Q9LPD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2155p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002155">
        <property type="protein sequence ID" value="TBU09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2155p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="16908" checksum="7105A700D96CFFE0" modified="2019-07-31" version="1">MDTGIKTDVRIRCNRPDIYILDKRKNKQTLVEDRITFQDSLQTVETGKIRNYDLLANELGRIYKFMTCDGIVAKYHKIYLKRLQISMNIKAYMQSIPEESVIKCYLGTEMHKQPEHSLKKVDNKEDGGIDENINEESDLEENYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPJ2</accession>
    <name>A0A4Q9LPJ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2009p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002009">
        <property type="protein sequence ID" value="TBU10117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2009p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="69" mass="7927" checksum="959F1A853A80B6A8" modified="2019-07-31" version="1">MPKGAGRALLSVILGAVIHKQPTFLLKQLDNEEDGVKTENTKNILPFILDSITQQRNQQLIRMKSWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ13</accession>
    <name>A0A4Q9LQ13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1870p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001870">
        <property type="protein sequence ID" value="TBU10297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ13"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1870p0020"/>
    <dbReference type="OrthoDB" id="2189598at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="462" mass="54207" checksum="945AAEA628C4D043" modified="2019-07-31" version="1" fragment="single">MFYLWTVKSMGRKERENEKLKEKRKKRQKRAEIFEMLLEISKKQEKNNITETKSSKDNKLHFLNKENIQKNKVKKSKVTGIDDKKSDITDKHRKKSEILDLNLKNKNQKKIFSDKIIFSSTEQTLSSSKKRITDDNMSEENSNNANKQEDSTLQRSITDDSNLIKNSNSIKKYFGVEDFQNTNSKTNIKDLNFFRKQYDEENKKLIEKIFKKVEFSSEESKNTFLNLRTNEIQDFRKTLPIFYEESQIVSNVKSNIITIIKGETGCGKTTQVAQFLYESGFSTNKKIGMTQPRRLAAISLSERINLEMNINICNYKIRYENTCNKNTKIKIMTDGILLKEIMKDFLLKDYSVIILDEIHERSINTDVLISLLIKIALYREKTEEKLKIIFMSATFDENIVFSLVEDILKKDKIEFENINSFISSIVIESRNYSVDIFYESTDPNNILESVLLRLKKILKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ48</accession>
    <name>A0A4Q9LQ48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1632p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001632">
        <property type="protein sequence ID" value="TBU10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ48"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1632p0020"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="265" mass="31948" checksum="23589370340F147C" modified="2019-07-31" version="1">MTHIFKNNILNKYGLCSDEDREKIIIGIESKVYRNVVSRNFREVIRVTDKALENLSMKMTPYDICSVVTPYNDEIQEMFGIGTYINASYIPTDLTHYIACQFPKKEFIHLFIKLITKSNTKLIISLIDCKEYDYLENFKCIDRDVIKDEYDNDLFFDETYKITEKYFLRRLRFFKWKDFDIPTKSDFLKFYNYFNDIRSEDTNIIIHCKAGAGRTGAFIFYDILKHEKNVDNFIFTRKFLYLRYKRPRMVYNDKQLQYIAGFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ67</accession>
    <name>A0A4Q9LQ67_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RuvB-like helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0533p0010</name>
        <name evidence="3" type="ORF">CWI38_1622p0020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001622">
        <property type="protein sequence ID" value="TBU10663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000533">
        <property type="protein sequence ID" value="TBU13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ67"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0533p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1622p0020"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="2">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="18481" checksum="68A356E87B8E8FB0" modified="2019-07-31" version="1" fragment="single">MSTEDLKRISTHSHIKSLGLNSVGEPIDIECGVVGQYNAREACGIVVELVKNKKMAGRSVLFVGPMGSGKTALALALSKDIGCKTPFYTISGSEVFSTEVKKTEILQEALRKSILIRFKEIKEIYEGEVVDLNVIEFEDPIKFYKKTIKEIIITLKTNKGSKKIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ71</accession>
    <name>A0A4Q9LQ71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1644p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001644">
        <property type="protein sequence ID" value="TBU10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1644p0020"/>
    <dbReference type="OrthoDB" id="2192545at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="215" mass="25279" checksum="A3DB0BEC4D57A549" modified="2019-07-31" version="1">MDKKLIKDVWLWSQLSFAFLYTLSILRIFIKIPILSNLPCFSLCLLLSISYIMTMSKKILTSEITSIVSETNFYCLIVLLSFPSKILLLPFYVSSIFNLVDFVVTNKRQYHKYFFYETCKNIIIKRDIFIFSVYLLDVVGIFVASVGMLFRISNVMTVIGYCGVVRQEYLRSEKMKIIISDFFKLLDSKVDKMPEIVKQWYVYSRDSKVKEIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ93</accession>
    <name>A0A4Q9LQ93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1603p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001603">
        <property type="protein sequence ID" value="TBU10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1603p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="100" mass="11702" checksum="A92F9F9971AD5BC0" modified="2019-07-31" version="1">MLFFRRCLSFGTEELGKLCQSLIETRQPNDFSKALVKKKEFKKFNKKSLICLKEGQIEKRITLTKEDKKVEHLATCCKKIQGYTYIRNNIESQPTPNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQD3</accession>
    <name>A0A4Q9LQD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1775p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001775">
        <property type="protein sequence ID" value="TBU10417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1775p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="104" mass="11840" checksum="8F40CCBC53773C43" modified="2019-07-31" version="1" fragment="single">MKKIGKVVVRTRKHPNELVDSKFLDLINREVGEYAGAHVPESITEAAYFMQAAQVCYNEATRKEMPRSARKEIIESKISKLVLSKDLLENARKQEMLSTSETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR2</accession>
    <name>A0A4Q9LQR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2121p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002121">
        <property type="protein sequence ID" value="TBU09750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2121p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="154" mass="17101" checksum="2B2B362AA57CA9FC" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDNEIQKCKLHPPAIPLSSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQT0</accession>
    <name>A0A4Q9LQT0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1580p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001580">
        <property type="protein sequence ID" value="TBU10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQT0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQT0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1580p0020"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="458" mass="54812" checksum="8599DB7F6EACDF9A" modified="2019-07-31" version="1">MRRRNYDQRYMDEPIINMKYLLEQPFIITEKELKHLLPEVDYSTYLKSFYSKKIHKFYNSFHEHEWFKERYIYDDYNIEKTKEFLQNYVEFTEKIVKICWDNTNEEIKINVPILNEEYFVDPELINVPKYNIIMKNISSLVPISLIQNLALKCPNSTKFSVLQSDDRESYKRSCIISLQNENNIDDSVRSMRNKSSPSCEFYCDKFILNENNMSFANVSFSQKDILFAKKIIKSLSDRYSVPDVLETIQSDLQSFFVKYIEKNLGENEKMKKDAIFKFDKSEILDFYILLLRYVFHYCFYCCRMFGSHMEMARCCGKYHIRSHAKNRDFFTRKLKIYTMDKDFSFMKDIKEEDGMIKHIIKIDEEQYKCNSCIKVFAQAHNVANHIKRKHPELIESIKKDMEIFSAFINKLDPFVLSIIEGINDTHLPSYLLKIEEDIIPVKYDIPKVFSGFLDKPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR43</accession>
    <name>A0A4Q9LR43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2030p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002030">
        <property type="protein sequence ID" value="TBU10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR43"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2030p0010"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="475"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="895" mass="105095" checksum="ADAAAD4D4C8ED16B" modified="2019-07-31" version="1">MFYLWTVKSMGRKERENEKLKEKRKKRQKRAEIFEMLLEISKKQEKNNITETKSSKDNKLHFLNKKNIQKNKVKKSKVTGIDDKKSDITDKHIKKSEILDLNLKNKNQKKIFSDKIIFSSTEQTLSSSKKRITDDNKSEENCNNAEQQEASTLQRSIMNDSNSEENCNSIKKYFGVEDFQNTNSKTNIKDLNFFRKQYDEENKKLIEKIFKKVEFSSEESKNTFLNLRTNEIQEFRKTLPIFYEESQIVSNVKSNIITIIKGETGCGKTTQVAQFLYESGFSTNKKIGMTQPRRLAAISLSERINLEMNINICNYKIRYENTCNKNTKIKIMTDGILLKEIMKDFLLKDYSVIILDEIHERSINTDVLISLLIKIALYREKTEEKLKIIFMSATFDENIVFSLVEDILKKDKIEFENINSFISSIVIESRNYSVDIFYESTDPNNILESVLLRLKKILKMSLNNENCMNDFKKFNLIKKYKNVVLEKDYLFDKNVRNDDSSGILIFLSSKREIYQLKKMIELEDLELIVLPLHSSLPYSEQKKVFQPYDRRKVVLSTNIAETSITVSDIVFVIDCGKSKVFLNDDKNILRYEIVNVSKSSADQRTGRAGRCSHGVCYRMYTRQSFNTFEEYNTPSILTSSLFETILNLKKIGIENIFNFPFLTFPPQNKINFALNSLKSLNLLDSNNKITKIGKKVLKIPVHPKVARILYFKEAKDILHEIILIISFLSVLKEWDLNDKDYSFVSENINQLFIDELDFSEKYINFILENEIVVKYAIIYLIFTKKCEHFDSFISTKTRDIYKIAFSISKEFKIDFCLNQLTLKTVEIIRKVIYHGFIDNLVIRSGNRFYFGEEEVFFGNKNCKNTLNNFFVFEYLIKGKEKYFMKNVTVVDEKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR69</accession>
    <name>A0A4Q9LR69_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2073p0010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="PITK01002073">
        <property type="protein sequence ID" value="TBU10005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LR69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2073p0010"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="215"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="949"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU10005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1287" mass="144079" checksum="A78EC5329DC2FF14" modified="2019-07-31" version="1" fragment="single">MLKQPLHHKKISSIQFSLFSPSQIRTNSVLHIDYPETLEHGIPKDNGLIDLRMGTIDRGFLCATCGQSSNDCCGHFGHIELFKPMFHVGFLPKIKKVLESVCFYCSKIKSSTSSIHSVAHKNRLNFVWNICKNKSVCEGDEETQPNDSIKVKTGCGNKQPTIRKEGLNLVAFMKGEESVEGKVILNGEKVYSIFKKISDTDIQLLGFDLIYSRPEYMILLALPVCPPCVRPSISLEGILRGEDDLTHKYADIIKANQNLKKYEQEGAPSHIVRDYEQLLQFHIATLIDNDISGQPQALQKSGRPLKSITARLKGKEGRIRGNLMGKRVDFSARSVITPDPNISLIQVGVPINIAKIHTFPERVTPFNIEKLTKKIQNGPFNHPGANFVIKPDGQKIDLRYNRTDISLTPNFIVERHMEDNDIVLFNRQPSLHKMSMMAHKVKVMNNLTFRLNLSTTTPYNADFDGDEMNLHMPQSLLTVSELEEIALVSKQILSPQSNRPVMGIVQDTLVGIRLFTLKNNFIDFRNSMQLIYCSDLILPIPTILRPVKLFTGKQLFSLLLPPINYSKGYYNGVGGDSSNEGDSSKEGVSSKEGVSSKDSKEGVSCKDSKEGVSSKDSSKDSTNNNNNTNNNNTNNNNNNNNNNTNNNNNTNNNPTNNILIVNGLLLLGVIDKKTVGTSQGSLIHIIYNDCGHERTCNFFDGIQRLINTWLVTISSFSVGVGDMCINKKTMHKIEESIERGVKEVRNKIQMCRKNEMERLPGMSLRETYESTVSVILNKTRDIVGSLAHKNLLSCNYLNHMILSGSKGSTINISQVSGCVGQQTVEGHRIPYGFRYRTLPHFLKDDTAAESRGFVQNSYISGLTPAEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKAMEDASVKYDRSVRNGRGVVFQFLYGDDGYDATYLENVEIKGVRGVEGMLEGDSRDKGMLEGDSRDKGMLEGDSRDKGMLEGDSRDKGMLEGVSNGIDNYNPLSNSTNKLEGVSNSIDNYNPVSNSTNNYNPVNNSIDNYNPVSNSIDNYNPVNNSMDNYNPVNNSTYKQQGVSNSTNNYNPVTDSTNNYNPVTDMTYKLEGVNIEDSNYNSTNKQQGFNTSSSNNNTNNNNSTNNNNPYNTNNHNNNNYINNTNNHTNHTNTNTNNNILNLALKHKIDMFGSKEYRIISKDTSYYNMLSTDIELQKILDKEWEEIFKVCCYLKEGRYALPVNVKRLLWTARVKYGKGSVNPYKIIQVREDLIRFINSNGIGYMGDSKDSSVVGGVSKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR81</accession>
    <name>A0A4Q9LR81_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1560p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001560">
        <property type="protein sequence ID" value="TBU10767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1560p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="11077" checksum="3331F4C7A0ED8452" modified="2019-07-31" version="1" fragment="single">DVQQGLNHLSNKQQGLSNSKDVQQGLNNSIDVQKGHSNNTNNNTNDKDYKVIRIGRSIISIKKKCINNRYLRGVNTCVNHTTNKQRDVNTSTSNYKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRA4</accession>
    <name>A0A4Q9LRA4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1424p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001424">
        <property type="protein sequence ID" value="TBU11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRA4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1424p0020"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12090" checksum="EA8C1A5CA0E8924B" modified="2019-07-31" version="1">MLYHKIVDLTNTTKNICLSFIVIKEISVTTTKDKDIVRTYLISDETGSIEYSAWNIQFEDDDLINITGGYTSLFKGKTRLFNSKNSMINRNGKIRKVFSLEPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRE0</accession>
    <name>A0A4Q9LRE0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1522p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001522">
        <property type="protein sequence ID" value="TBU10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1522p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="409" mass="46863" checksum="5F2AEAB59C47665C" modified="2019-07-31" version="1" fragment="single">MGRKKNLSSEISKDTKIKAANDADEVKKSDSEVKKCKLHPPAISLPFSSYTKITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLSIPEHIRFRNRLMALRKIFDSVTADPKEWPRIVFFAVQTRYDNEKFDCTGTLVVLEKMAQSEMKGSKIRREWSDNEIGKVVVRTRKHPNKLVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQICYDEATRKEKPRSAWKENIESKISQLVLSKDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDDAVTYDDYLIPFVSDKHPTTFPSLHEFVNIINWLPNWKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRN0</accession>
    <name>A0A4Q9LRN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1858p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001858">
        <property type="protein sequence ID" value="TBU10311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1858p0020"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="654" mass="76886" checksum="9D2F747A2D03472F" modified="2019-07-31" version="1" fragment="single">TISSVCASRQNLKFAVSTHFDSIIQYTFIPSGTPIQGNFKKKRKEIQGHWKKNIIHITSESYCDRLCYLSDDTKLVGLFIDNSIRLYHNNILTATYYLSSFSSILTASNNNTIAVCDGMNLLVLNQTLSPVYTDTLSFRPVDCLFNKENLVLSDEFGYIVIYSICPFLKIYKKQSLQQFFECEFLNRNLEIEEDFIECNGDPIYDINKNTKILENNFSLKDVLTNKTNNIFQIKNERENKNEKPENIEEFMDIEMTKKSKNLMVGNSYQMYLENMAFEHLKDDFITPTQFKKKYLFTNETQEETNNSESTCLTESSITSDDNIISESTLDEESYVSEITDSTYSKESDIIITTERIVSETFNIELEKYVENWLLGNTDFQSFLPQIGDKLYFFSEKYKEFRNYELREEFNCEFDNLNNLEDLEDCIVEVKDVQIIKYDPSYLQVECIKTEAEDLNRNKRIKNGNEFNKKTFFIKYYDYPNGGNIFLLKAVFDTLNEFKFRRNTVVSVVYDGILYTGKVLRVERDGAIVLYDDGTEEWVGRYDMYCNYTSYGGYIATEMLDGLLNIIGNFGDVRALFVKSKRKEYLERCFYFVTLNLIKKRILNGFYRSIESILWDFDNLYDNSIYLDESVVKRCEEILKEVYSLFGKNFRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX9</accession>
    <name>A0A4Q9LRX9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1871p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001871">
        <property type="protein sequence ID" value="TBU10295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1871p0020"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="29350" checksum="04F4F5F89831E9F6" modified="2019-07-31" version="1">MLGDYICFKRRDHLIRAVFGFKTVLIKQIIQTEHALAHIRVNKMMALFVEKYYGIPKAYIKEYVKDCEACTRFNCLKTIQPIYINHITKIHALFIMECVDCMRFTKKLHETGERRRIEHLNNVVYAYKRYVNSFNNSLSESIIVENEASTIVPAIDIDHDIVLIRSDVAKNFKKHRKRIIESKNSNEFKSSFDDKKDFDMNTKTKSAPFDSFYVNFIFKVIAILMNNMIKVKNKDGETRKVFRGVTKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS23</accession>
    <name>A0A4Q9LS23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1858p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001858">
        <property type="protein sequence ID" value="TBU10310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS23"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1858p0010"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="28833" checksum="D280114AE0C5EC07" modified="2019-07-31" version="1" fragment="single">VKGKWIIITGATDGIGKELALNAAKRKYNIIIMGRSSSKLDEVYSLIIKENVKCKKIICDFSKECITSFINDSIEIGMLINNVGCVGEHPKLFGEESSVSEMINVNIYNTFLLTQKVLISMMNRKNGVILNIGSFTGDMPCPVLSVYSSTKAMIRSWSESLHYEMRPYNVHVECINTGYVATKMSKIKKPSFFVPSAKTYADSVLNSFGNSSVSITYFPHLLMYSVIKILPRTFLGIITFFSLSRTRNMAIEKKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS60</accession>
    <name>A0A4Q9LS60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1467p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001467">
        <property type="protein sequence ID" value="TBU10936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1467p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="418" mass="50481" checksum="8F78BB6A71E57676" modified="2019-07-31" version="1">MHEEDNYEEESNETEKININNKYFICNKKPFIFSIDDLTPCYNIENCKEECLEFYKNNILSYKASIFIERLGYLLKEDIIEINQEFNKNICKNFKIHEKAGRHFYTINSEKNKNYFFNEHKTENNNFKITNSTFDTYIPPLKSPGLPYKIKNMNLFENLFKKILYQNDLQCEWNECIKILKNNNIFNSIDCNIQKKRIYDLYLEERTKYFEKFNLEKNTNLSKNNIISPFDPDDLKEICEIIKSKYEINPELSYNDIKNDFDLQKYEKFKILESFKLIYKNMYIDIKNNCKNNKESINSSDANLLSYDNNLTQSLYLEYKEMLNDMYKSGMIFYKMKFKEFIVLIKEKSIFIRMLKYSGFPVKVLFFEFIQTINNRLKEYENKLGCNEPVNLNSIDLKAIQTYFIRRNNELEKEEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSC3</accession>
    <name>A0A4Q9LSC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1755p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001755">
        <property type="protein sequence ID" value="TBU10445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1755p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="660" mass="77846" checksum="C7F2128EA157B5E2" modified="2019-07-31" version="1">MDYLVHFYRFFMHLVNINASLDQKNGKRVLPEEITILEIKHPRHIESFISENPKICLKKSESCKRTKTGIKTSEKEDGDTLKKITRENQMNDVHHSVESVISEDIQSQIIPKEKSHENPDITSNSPISSNYLKVDSKSRFQKIIAKYNPRMGLKSNDSLETQHTADKGHIKPYIPCKNGNNTISSSNIYYHDNITKKVNIPEDFRRNRIIPTDRIFYSSRKKQSVVETKKKPAEQKEQEKEQKTILNKIKPNIRNVQNEPKFLELFKCNVELKDHDKSITTIKDELIDILYPEKSEKVVNIQCIDECFNVKNYLFYDAKNKTLDFTLETFKENYDFNKILEVGKNLVEIEILSYSKFDAVGIAETIKPIKYSEIISEVKKSQLNIICVELNYIYEKCGNFTETSIKKGRVIYMHYIWVVIKYLTDLLFDEKLCRNELHYINTLNIITFFIRKLLLELLIGFNFDPQKVETYRILNTISYYSANAPDYKKYFSCNLFTIMMRASFRFLFDSVCKIDYKWNTDLIIQLITNLQRHLRPTNNKRGIYEFFHKNFLVRTFLGKYDEIYTELRSVKSTNKSILKLINEASEKSNSSKVVEENPDDILICFIKSEFKIIWINCKIYSCKFAFLKFRHKKSYEKILNEIIQQKKTYSPPEDPSTMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH1</accession>
    <name>A0A4Q9LSH1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1218p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001218">
        <property type="protein sequence ID" value="TBU11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1218p0010"/>
    <dbReference type="OrthoDB" id="2191713at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27545" checksum="61C6A039EA28E5D8" modified="2019-07-31" version="1">MRNEQYFRNDNVCKKIINLEGITSKNGNIAILDKKENDIQQSICSEHILLSDFVSRNYYEILSIPNVNRKNIFYVFKDIVRGLSYLHSNGIVHRDIKPANILFYNRNGNFIVKICDFGHMKLVDEVIEEYDSGYGCKESGMYTKASFSSDIYSAALVYFEMLWPMKTVMEKDITIRRMKEYEQVPEEFKSLFKEESYIIEKCLKYNSKQILTCRELMRLLLNYEKIFFGKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSI8</accession>
    <name>A0A4Q9LSI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1630p0010</name>
        <name evidence="2" type="ORF">CWI38_1173p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001630">
        <property type="protein sequence ID" value="TBT98714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001173">
        <property type="protein sequence ID" value="TBU11499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1630p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1173p0010"/>
    <dbReference type="OrthoDB" id="10669780at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT98714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="247" mass="28526" checksum="68681338AE2E76E5" modified="2019-07-31" version="1">MVFINSLPILIQKTIFLSKLSSKISISPTTISTKNIQIELPPFTDQTITLSSKDLLQFLNINSSTLNLKYDLNLESCSSEEENYISNKKEKSFYGIFKSSETIKENKSDIFLILKYKLSINKCMVDIRKCIRVYPFIHPFQCTLVPILVLNIFPFPYNFNNSNLKFIYKKSLEIICEGIVTVNLLINSEEISFTKNEIEFTILSSDLGFLSLIDENTALKMCVFDNYCLFYFFEEDVTTVVRACYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSK8</accession>
    <name>A0A4Q9LSK8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1292p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="PITK01001292">
        <property type="protein sequence ID" value="TBU11267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSK8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1292p0010"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="146"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="164"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="31842" checksum="55E1AE9C681CCB7D" modified="2019-07-31" version="1">MQFKRKIPLNSESSVKGNNGITLVIGGCGLYTGAPYFVSLSSLLSGSDLSYIFCEKETLIPLKVLLPEAIIVEIDFHEWILNRVSVCVFGSGLGRPTKEKCEKICRILEYLMKRNIFIIIDGDGIFFYSNNFEFFQKYKNIVLTPNYNEVKYLKDNNIHYVLKKGFVDVIEYNDRKIEILNRSHEIDDTNQNVLASTEMTLFKPIFVKRCGGQGDILAGILATFLSWTKTAEPDDVTDSIKTASIITRKASEFASKKYGMALKTREIIFEIQKSMESVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSM7</accession>
    <name>A0A4Q9LSM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1581p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001581">
        <property type="protein sequence ID" value="TBU10731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1581p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="21979" checksum="B5150E69B8DA768F" modified="2019-07-31" version="1">MDRLKFCSSKVNLANNGDLLFDNLYDYVHIDENKRFITKIMFMTAIFVYQEPAQINSKNRAKKTMITKNLESVTAVHCKNMIIDNVIPAIKSKFPPVYKKKTIYVQQDNAKPHFSDNDAYIVALGSANNWNIKSKAQPANSPDLNVLDLADGGNGYKIPYLSKRKLRREDRLLEKYLCSKEVYNKSKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN3</accession>
    <name>A0A4Q9LSN3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1126p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001126">
        <property type="protein sequence ID" value="TBU11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1126p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="170" mass="20278" checksum="ED4E06388C811FA4" modified="2019-07-31" version="1">MAQTIRSNENRFNDKLAIVLTSKFQKASKPYIVSNEDFVFSNIEKYVIHTFKDSYIREFISKVKNEILNISFPYTDLHLKSQIDRKYILEDDKCHQTDQSYDSQDNSVMMSLCKLKIVKESCIIYCDKKVTSVCLFHITREFETLSYSKYYFCISFHLFLYNFKICKSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSP1</accession>
    <name>A0A4Q9LSP1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1123p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001123">
        <property type="protein sequence ID" value="TBU11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSP1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSP1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1123p0030"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43845" checksum="FEE149FCB5FE3EBB" modified="2019-07-31" version="1">MKKKVGRMTDIDIKHIIESTWTYKDKNLFNHFYTIYGKMWHLYGSSIPCKTEKDIKMYYRYYRKYGNVVGGESSGGGDSISVGGSIDVVGGNNHRLDNNCNVYNNCNNTVIEGKPFRDTMDNTYFFCSSDVLSIRMAIKRYKEGCVNNGNEREKPYDFKRIIENICKETYSSIKFNGGEGDENTVVGDIVVEDVIVEGGDKNVIEVIEENKEENKEDIIEVSKNEDKKDLIDDKELNNTNTTKTLQHATPRRKRVKRILPVIKRGFIKKISKRDILSKWSINNRQLFAIYFPYFNKNWVMMSEYFSDKKAGDLRIYYRHYYKNLSMNEQKLELSLREVERDLDRESVSDVGVSYCRRESGVVYLDMCGIIFEGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR7</accession>
    <name>A0A4Q9LSR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1171p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001171">
        <property type="protein sequence ID" value="TBU11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1171p0010"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="787" mass="89658" checksum="D2D06E346366262B" modified="2019-07-31" version="1">MTQENTQPENQNQEHHKYDVEVQSLLSIIINSVYSSKEYFLRELISNASDACDKLKSSWADFNAQNLPIDSPSSLCIHIIPNQHNKTLIIQDNGIGMSKSNLLSFLGVIANSGTKKFKEALAQQGKKADVGTLIGQFGVGFYSAFLVADTVQVITKHPQDTAYVWESSGLSGFTIQPAPTFPLSHGTQLILHLKEGESEYLTKSKLESIIKKYSMFIEYPIYLHEEVEEEVDIVEEVEGEKVEAEKVDEVEGEKVEGEKVEDEKVEAEKVDEVEGEKIEEIKDEIKEEIQEEIKEEVEGEIQEEVKEELKDEIQEEVKEEDTPTIQPTIQPTTQSSIQPSKKTVKSIKQHHVNKDKPIWTRDPKEVTQEEYSQFYKTISGDWEEPLMVKHCYLEGLVSFYMVLFIPKRSRFNMFEKGNKKDSIKLYVQNVFVTDDLEDAVPDWMSFVSGVICSNDLPMNVSREFLQGKNALKMIKRSLGKKVLELIEDVARDEEKYKIFYKEFSAALKLAVRENESSDRHANLLRYYSTKSEDKMTDFKGYVSRMKEGQKQIYVLTGLSKEEVTRSPFLSRFSDYEVLLMHEAVDEVMLQGFKKYNNYDIQRINAEGVELVEDSKDGNGKENKEEERKEFEGLCSFIKEVLSNSVEKVIISKGTGVIPCVISTTKWSHSAAMENIIRSQPGAENNQFLKLMGTSKKILELDINSALIKKVKQVYDEGNKSMLKGYVNIIFENALIGCGYKIDDCSDYSNKMFSCIERAFMSEAGNKNEGVFCGDVCGDKVEELNDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSU1</accession>
    <name>A0A4Q9LSU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1255p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001255">
        <property type="protein sequence ID" value="TBU11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1255p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="27975" checksum="FAE348809A32AD9D" modified="2019-07-31" version="1">MAKKNQRNIIKTLKKISWDLLSTFVNMMGIYVIFIVPFVKDKQNFSAPAFPKHFILLFLFTRIRHMYNSRFSKEYIIIRQEFTCLLFTLFSTIIDEYLEKHPLNFDEKSNEIFFVIYPIFIILFHANILINLFKFKVKNDSKLEHLFYLFISVYAISVAETLFKPMIFTTTQLFSFRIFIYSIELILVPLILWYIALSQVTVFLIFYFSIIFTLDSKFLYWVTSNPYNLLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV6</accession>
    <name>A0A4Q9LSV6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1087p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001087">
        <property type="protein sequence ID" value="TBU11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1087p0020"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF4">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="11">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="458" mass="53250" checksum="15026C9EE6184E53" modified="2019-07-31" version="1" fragment="single">MENNLEEKEITTKLKLINAFTKNKDIFTPSRGNLIRWYICGPTVYDSPHLGHARTYVSFDIVRRVLENYFGYQVTYVMNITDIDDKIINKAKETKMEVSDACKIITKKYETEFFEAMDNLNVQRPTFTTRVTNYVEKIVTFIEKLMEKGFAYESEGSVYFDLVKYRENFKHPNFVNESAINEETEQLENIYKKKNKIDFVLWKKSKEGEPVYNSPWGEGRPGWHIECSAMASDLFKDGLDIHSGGCDLAFPHHENEIAQSQAFLNSNLWCPYFLHSGHLSIDGLKMSKSLKNFITVEESLKNFTPRQLRILFLNTNWWAPMTYKLESMEYSKKIEAKLMNFISISDSFIKNSEIEDNFKNVTDQDSMILEILENTKISIHEAFCDSINTFKVLTAILNLITVIHQKIENLSIRVIYVAKQYVVSILNLLGVVEEKKGFDSLDQDVLKLVCDFRANVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTH1</accession>
    <name>A0A4Q9LTH1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1036p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001036">
        <property type="protein sequence ID" value="TBU11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTH1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTH1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1036p0010"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001546">
        <property type="entry name" value="RNase L inhibitor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="75"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="359"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="613" mass="68717" checksum="2F801C19C1F8B538" modified="2019-07-31" version="1">MAKNIEKSKLTRLAIVNPELCKPFECNLECKKACPINKMGKDCIVVKKDSKISQISEYLCIGCGACQKKCPFGAITIINLPTSLEKDMSHRYTENGFKLHRLPVPRQGQVLGLVGTNGIGKSTALKILAGEIKPNLGKFKETPDWIEILDNYKGSELQGYFTKLLGNELESVSKIQYIDSVPKNLKKEFSNENLTVKEVLAVKDERNLKDFFLSLLSIENIIERDLEALSGGELQRFCVLLTCLKKSDIYIFDEPSSYLDVKQRLLVAKAIRSLSKADKYVIVVEHDLAILDLMCDFGCVLYGKAGAYGVITQPYSIKNAINIFLDGYVPTENMRFRQEALKFNISEKPETSGAEISYNKYDAMKKTWKGNKSGFSLNVEAGSFNNSEIIVLLGENGMGKTTMVGLIAGVIKSDDNNETFCGAKVSLKAQKILPKFQGTVRELFMSKIRVSFLDLSFITDVIKPFGIEYLYDRTVSSLSGGELQRVAITMCLGKEADIYLLDEPSAYLDSDQRIAVSKVIKRFIYNKKKTAFVVEHDLIVGTYLADKVIVFDGKPGIKGNASAPLDIVNGMNKFLKNLDITFRRDPENFRPRVNKPNSAKDREQKENNKYFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK3</accession>
    <name>A0A4Q9LTK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1473p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001473">
        <property type="protein sequence ID" value="TBU10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1473p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="750" mass="88535" checksum="3FAB173D5A0A4A09" modified="2019-07-31" version="1">MSIFLLTFNITVSQQTVAIHFYENTDSTLKENFLKNSQSGIFQATLYKKYQIFSAELSTEYQKTFLIDLDTFYLKFSNEEEILDGKTYNIYINNSLLSYDEFTYFYNIVMSFPSFIDILNEYNYRLIFTIMNIFNFKHDKYFKRFIRLLWVSVVFNPIAMEKLYSKTSTRNEYEYPSCISKIALVELLKLYRVSEETLSGIKTDKFDVLTLLGFQNDIIYINEDYLFINEFTMKEILAIHKKSKFFLKILDFFFEIHVFRSMILSNIFYEKKHNDLFTLSLFRTCTDILLLRCEFTDDLIKKLYQVFESKSLKTLSILYSDFRTLDQISFLKTLATERLNYIGKNEGSASYFSVSEFYLFICPIFSEIINEMYKYEKNLNILPLDKQISFDDWRKKLDIKIQLAKTKIEAFKQLEAPFQAYISMELSSKFLTYSFTTVNLKEINQIQIYFMYANLTNFSLGEYEICRDIVSMKFTLTKIDNIFLSKILLFTSLKELRFFRATLLLPNKVTNIDNNTKIENIIFTNSSVDNQHNFVQFLNQMVILKKLEISSPGKNSSPFVWSSGYLNLRLMNLTLLKYSDLSNSGVDLFSFPDFPVLEEFELAYKCTEGTIHNIFANRNFNFLQKLYFSGAKLGKKDEHSLEKFTDLLYLRFSCNCKFSDLKLSQLFNLNNTYKLKELAIYDIEIDYCDLVFISNLKSLENLTIERIASQIKVAIVAKAFISIKKIEIANIMISKSEIFEEFGTRLKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ4</accession>
    <name>A0A4Q9LTQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0940p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000940">
        <property type="protein sequence ID" value="TBU12008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0940p0010"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="353"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="477" mass="55922" checksum="27E397BE655B1CF2" modified="2019-07-31" version="1">MFQFFIIVWLQRLKGRDSSFTYDDAMYHYRIGDVQQALDIFTNLHTENSSSTAVNLGYAKVLYSCGKYKKILDLFNEEKNESISEIVENARMNKKKAERNLEENIEDLYTESPYNIEFLEKIVLKKIKKNLLVEALQLLSSKKSLVENNKKLLQLKALIFVFQDKIEAAEDIFIKEFRDNKTMKQFKSIRQEYKNIENIRDKRQRFYGLRDFLLKIDTLDLGSLLPVSIYHNIKLGALKELLSIGIHFKAKGLVPKAELYNKMADTDNSRYIYVLAYLYSGNISEAYSLVETLHFEDEKYRSSARSKILTEKQRMKEEEEEERERQRQQEEWQKQQRRSRRGTKKSDDPDPKGYYKSLGVQKTATKKEIKKAYIKAARKYNPDLIEDAKEKEKMTKKLMEINSAKSVLLDDEKRKDYDDGIIEGEEPFAQDFDQKQFSDIFSMFFGGAGGNMGGAGGSRFFSSSRPGQQQTYYYYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ7</accession>
    <name>A0A4Q9LTQ7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1445p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001445">
        <property type="protein sequence ID" value="TBU10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1445p0010"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="177"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="240" mass="25989" checksum="CD36B313BB29CCDE" modified="2019-07-31" version="1" fragment="single">YLTTGSSELDKLLNGGIESGGITEIFGEFRTGKTQICHTIAVTCQLPTESGGSSGKAMYIDTEGTFRSERLVSIAARYNLDPEQVLENVSYARAYNSDHQSQLLIQAAAMMSESNYSVLIVDSATALYRTDFSGRGELGARQIHLARFLRMLMRLADEFGVAVVITNQVVSSVDGAAAMFNADPKKPVGGNIMAHASTTRLYLRKGKGETRICKIYDSPCLPESEAVFAITENGIADPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU46</accession>
    <name>A0A4Q9LU46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1285p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001285">
        <property type="protein sequence ID" value="TBU11281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1285p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="719" mass="84779" checksum="8FD1AF331BA4F616" modified="2019-07-31" version="1">MRSDRSDVDFQYKFLNDCSILYYEVTHVFMYEKDNFISFEVLNHILALQKSEKLNGIIECNFNLYYFLNTTKEITEIPDEINHTNIKTILLGLKCLKAVNCKNITKYIHALLVKILLNHKKNALMKNYMYLGGLFDLNFWSNIDEYIKKSFISGFLEIYMLKYIFYDGNLIVLENVKSDYYTSIFNDHIPYKNILINSCKVFLCLEKMLLNTLIFNFFQILLNVMNLKSLILDGLIEYEIPNLKFKFHIFYLETFKSIVFFNFMKSSSSLFLENLSVLIRNDIEFLQLELLKVSRNVLGLLLDQKNPIGLVLKNVLIPHSTVILNRNINFCEKLRYAQFQNVGINPFWWNNLFFKSNFQTLILSFNSISSEESFIREFSKSRGTVRAILHLEISFYYTEIPKEFFDSLLNLNHLRTLKLQTYITNEQTEIYLINAIKNMNRLENIDISQNFFSTKSYNILFMKDGIETLYLKNDEFEINILEIAFTGNYKLLKQIGFSNMTIGITGLIEIFKLENLEMLSFECCIFESIDNFFFSYSKSQYLKCLHLHDLDLNTNNFVYVLIKLDFLEILEISSCKIQPGLLTGLGLMCDKSLSILSFKFGFLNSNDLNRIKNIKVLEDLNLMECRFFQCNFWELGNDCKFFNSLKVLNLCDVKINIEDLIYLRKFKNLMKLSLTISDSYILSEKDCLIYLLALTHLSKSKIKLVIESKLLYRLYINEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU86</accession>
    <name>A0A4Q9LU86_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0854p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000854">
        <property type="protein sequence ID" value="TBU12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LU86"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0854p0010"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1407" mass="158756" checksum="16023AAC4A649A82" modified="2019-07-31" version="1">MSTFVFHGYDILSCIRKVLFSFVMPGESQKVIRVLEAFSSKYYEDNKVEIGLDKELEGDKSDVLEGDKSDMLKGDKSNMLECDKDQDSKLHPVSNKDVKQHPLSNSTSEQHPLNNSTNTYHPVNNKDSEQHPLNKKDSEQHPLNNSTNTYHPVTDKDSELPPTNPTNNNTTNPTNNNTTNPTNNNNTNNTNNTNPTNTTPFTLHDIYILSYAIIMLNTNLHNINVKIKISKESFIESIRNCNITPYYNNEYLLSLYNSIKDKGLVFNDSNCMGVSNYEVYKELTGYYSSRDTVRVCKGCYSNRGCYSNNTCKDKDSNNTFTCINTLYNTSVNNNTPITIGSDINTLLSKCSISKDIGNTPINNTPISISTISNTPLNNNTVNNTPLNNSNVNNTPLYNNTINNTPLNNNTVNNTTPISLSYTLCPFYIISSYTYIINNTYKSITPIIPYHISCYYIEICKYLHLIEPLIYYLEYISKYLDVKIEEIIDIFIEIVQDIDKWYGDSIGVGVGGVTNLSDVQQGVSDRGSNIKGVSNMDSNIKGVGDMDNVLEGVGDMDSKQQGVNITSNKQQGVSNNTDEQHPFNNTTNEQHPFNNTTTNITTTNHTQLLTLLSLPLNILYTLYTKCKKKEHFISKYENVYNKYIRITSSLPDKYYILLIKYIVYNDSSDKGDSTNDYNPLNTGTNNYNPLNTGTNNYNPFNTGTNDYNPVNTSTNTLPPVNTTTNTLPPVNTTTNTPHPLNNNTVNNTPLTTQHTNNTPSILLSNNTFYLWFLFLIIDRNCFRIKGVLNEVCIIFKGNINYMSYLIEKVVELRLTGVLCTFIKEWRLSVISVLDKCVKEDVECIDSSVIDVIERYIFKYCSVEECMLEGDRVVEGVSDKSMLEGVNHKGSDIEGVRDKSMLEGVNHKGSDIKGVNDTTDEQQGVNDKGKEEGVNHKGSDIKGVNDTTDEQQGVSDRGSNIKGVNICTNTQHPVNNNTNTQHPVNNNTDIQHPFNNTDLHLCFNFVLNLQYKYDMFNYVVIKGCYYNYTYIMGYKNKRYFIERFDVCLKDIRNVFLFFMKCNSVMNNKVVERYFMRRGGSVNTSKSSKDLSNINSTTSVSSKDLSSFNNTVCGTIEPSTINNTTLVSSTINNTTLVSSTINNTSYDTRTVTNTPLNDSTVNNTPLNNNTVTNTPLNDSTVNNTPLNNNTVTNTPLNITPSLCPIDDLLFTDLEERICYMLYKVDTINNTKLSRYVLWIVNLISSSLPLFLRVFKNNLEYFKNMNSNSLMSICKIFSSRVCKVMDGEIVCVEWCNKEHKDVYEEVYEVVDVYVSNGVVGRECFTFIGKEREGEGKEKVDGKKKDSESKDSIVEDNSIIKDNSIVQDNSILKDNDILKDNGIVKDIVKANKVKDVKGDDNDNSVDNEVYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB7</accession>
    <name>A0A4Q9LUB7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0862p0020</name>
        <name evidence="2" type="ORF">CWI38_1253p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000862">
        <property type="protein sequence ID" value="TBU00913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001253">
        <property type="protein sequence ID" value="TBU11351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUB7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0862p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1253p0010"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38379" checksum="3113C20C900C6F51" modified="2019-07-31" version="1">MINNIGFLDQNIEFDIKKYVPNKEIAKEYDYGPFTPDLDALTTENFEIDLSEIESIEKTDQLIYCTVNSEEQSGIQFNVLKEGEKEVFLHHDISVLNTVVDSEYMNINDQHYIVLASYDTKLEIYDCCTFNPLFPQFLLKGHESSITSCKSNKKNLYSGDEGGTIIKWDLSKFEIQEKIEGKKNITRMFLENDILLYSTEFHLSINNSFQNIDSIKFHNEIEYFIIKENFIYVSDSIGHFYFYDLRYIDQPVSKKRLHLNSLSCFDINRSDMLVTCGLDKKIKQFNLSSLNKVQTVNSDDMVFSVKFSPFNDNLCFYGGPENELSNLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI7</accession>
    <name>A0A4Q9LUI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dopey domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1308p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001308">
        <property type="protein sequence ID" value="TBU11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1308p0010"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="7">
        <location>
            <begin position="1937"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="850"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="948"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1144"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1700"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="850"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="956"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="2263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2263" mass="262306" checksum="4E1BB763926659FE" modified="2019-07-31" version="1" fragment="single">MQPEKNTDTRYNTEIKKKLDAFKTAKQWSDFISLLSSLDTTLKKHNTTYIPHKTQLFKRLSQCLNPALPSGVHNKVLQTYHIIFQKLDTQNFIKNFNLYTLGLFSFSIHTRLILKSQYVTLIHTHIIPLSPYLHPFISNILLGILPNLDEENTDHYSQALKCLKDLLTLIPLPLFNTSLFYLLQTCTHLRQPITNYLIKYSIQYKVYITLQTIKAFSYSLKDKEIFVLRSILDILIMKYNLKKILEYSGEGSGGVGGEGGDVGDVGNDKNKDSSGDSDKDIDNKDNIDIRDNIDIRDNIDNTPIIDKDIKDIINTDVKDKERNMILDISFKENYNMDNKGDNDNRGNVLGNNDIGNNDIGNDTLNNPLNNPLNNPLNKDTITNNNPLNTNNNNTNNTPLNTNNTSNNITLHYIVDLSVNILKLFLKRDISLTKRVYSFYEISDSINKTSLNIICLSLYELLKRKDFISFFKIMICLSDKKDVCDSVLLLITPYYLYRIYEVYGIVEGYMGDISYMGYMGDISNRIGDSNRMGDSNRMGDRLENNPTTNNPYTNNTTNNTSNPYTNNQYNNLININVDVLKYVNLFHDTVEVSFIWKLVITSFIKRIKGICNEEGDIGDEEGGSSDSGSSYKGDNKGGSDSGIGDRGSSYKGDNKYKDIRHINNSTNNNPTITNTYTNSTNPYTNNTNNPNTNPNPTPTPTNNTTPYTNTPSTLITPLPLNHFIYVLSFFINNFNFCDKEVLEIHILFLFYLCLKYKKYFKKEELTVFLLLCIERMEWCCDSGGSGDSVGGDIGGIGSISNIGGIGCYSASSISDMYNTISDNINDNSINDKKNNKNTKVINNKDINNKDINNINDKNNKDINNNINQHNNNTHNQHNNNTHKNIDSLNSLHISIFNYYEGVNDSIINNLDIVYVGCYLLILRFFKDKKNFHFYNLILVKYLERMGYRGKGDRGEGDSSSSRGKGYNNISINNNPSININNPSINNTTPHTKHINNTPNTNPYITSINNTTPYTKHINNTPNINNTTPLPLSFLHLYFNIILQGSVNELENSLKIFKNYKLEGFYSLELFKKLWNNFNFRMCYLLYEFNILYCCIFERYVIIRLSGISNNIEYYSRDLDDSMCDSDIMCDGDSICDSDKNLDNSNKNYKSSSNKSKSKSNSSKSNSNKSNSSKSNNNQYNNKYTNQYTNQHTSNKYTDVYKTSNLLLFIINVLRSEELYFMDAFVYLNRILRESMWYKGNDRDIRYKGDISNTIRDNSNTIRDINYKGDIRDTIRDINYKGDNSNTRDTYNNSNTYNNSDTIRDINYKGDISNTIRDTYNNSNNIRDTYNNTPSYNTPSYNTLSYNTPPNISNTSDANIFLTCLKRIKHFNSIYKFILNKLKNACIESKEGYYYDIIEYDIVYGVFDCLINMFEYCNEFIIFLRSNVYVQGDGFMVFLNNGVVNVRKVLFSSFLYFVINDVKCDVGCGDGGCGCECGDGGCYSKDSNYKDSNTKDNDYKDSNTNNTNYNNHLSEIRRVRLMALFLISKMVDLNMLESQEIISYDLNPFISFIIKNINDVLIVWECLPLLKILTGNEQWVNIYFKKVFEFLVVYFSKKYSFFIFEILNIELRNKVVREVVSSNMLWDMDVCVVQGYFSYVFGNKEYFGDVLEKLVCGCFRYVEGKVGGGIRNYDILIGGSIGYVGNREIVEELKDSKEIKDVNDIRKDVKDKNREIKDIRREVRGNKEIVEDKNRDVKDNNRDLNELRKDNKEIKELRDVRGNNRDLNDIRRDVKDKNREIKELRKDKNKEINDVKKTLKTLLNDVLYDKYSTSYMFTGLNIKETSNFICMDSLIEEFKNINFKKCVDLNVEPYILLLDFIFLKENILFAKCLLNFKCESIILELNSSKLNLYMIYLEKFNKNIEIFPFLCKIEESFSEERILVILEQSINILNIMFLGRIVIRILENSFTVFLRTLDLPNKKKENKDILLLIKVIRNILENINIERYSLLFNNVVYGLLRQRNYLYSESLGILGLLKNWKKDFFDFFCDQKFFNDSYENILIKKNLICSFFSGEYEKIDELYNRMEQGFFVSKETDSLNKCSIIRRIAFLVFCLDKKIIYSKFPPIIEIISEFITNTSSNIKKEIIFLIKIILIKIDTEKLSHLWPLIFCEIFNEKEDLEVECETVRLIDIIFTFNLEETVEMLCDYVGGVVVNDSELNSSFVHYLSLKSGDEQSRCEIKFEDKIVPLCKFIDVKSKSDLKWFYENCNQYFTEARIFGREVDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV43</accession>
    <name>A0A4Q9LV43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nucleotide-sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0712p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000712">
        <property type="protein sequence ID" value="TBU12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV43"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0712p0020"/>
    <dbReference type="OrthoDB" id="2191964at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="35237" checksum="CBF405F8EA2F17B1" modified="2019-07-31" version="1">MKKYLAILPVFLHSCINGYILRKFTRDRNTPKCLPMMLIELIKLGISIFIKSGEPIKYNLEITVPTVFYFLQNLLLWNFAARIDPLYFATCYQSRIISLCIISILLLNKRFKMHQYFGQFLIFVGIILPEIFKENKIEKNNELIPCLGIILSGFLTSLSSVYFEHRIRNTITYFWDYSFQYSIYAVTLSFIASIIEFTVNEIDIWKFVLNVNFWLIIVTNSIGSMIISYLATVICPLTRTFFMILASAASTIVITFLLDSKLDIKNLFSFGIVYLGTSIYEYESLRKMFVKVTPKSKSPEEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV82</accession>
    <name>A0A4Q9LV82_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0816p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000816">
        <property type="protein sequence ID" value="TBU12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV82"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0816p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="425" mass="50836" checksum="73F2924DA13E3CA6" modified="2019-07-31" version="1">MNQIIQFIFLTNRYVALKGNNKDYIDNLRIEICRFLDLYVESVKNQLLESLLYDLHVMIIDEKNRTEQTCSEILKCIPKNSLDFNFVILSYGLNPFVSNFLVFSLHKNETHLLINFISNEKISTAFKENLLLLNPRTTYLFILRFIFFFEKCFKFLNRISTKYDRVFIIQPKQSEYYEKNTLIEILRKHESYFSLKLVIMIEKRFTNIIKNRIACLEDSIIENIQQYVICALEYEFILELIERAKQKIQSISFLYSDLYSVFKRDLNENSKSNVSSKNILNKLNYLKNESVKFRINKYIIIKNHKISTGLQKVKEFVFYCIFITRRCKIDDKIIQVYSLDLFLYTLEIKRSLQFSNLTLNNKIKYDLRIIIKKQINFDPDILMFKIMHICDLTRDFYDVKKVLLNLTATSPSEFKEIIKTITNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV89</accession>
    <name>A0A4Q9LV89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0701p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000701">
        <property type="protein sequence ID" value="TBU12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV89"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0701p0030"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="389" mass="45311" checksum="53CECCCBD01EF415" modified="2019-07-31" version="1">MSRSPLYLSLTKENSTELYLPGDILVFDIDNTLYSSKCGVEKLIKNKIYEFARTLNIKEEEIKEIAGEYTKKYGLALKGFILHHDVDPLRFNELVDESVELGKYLEEDRKLKDFLNNINLHKICFTNASKVHAQRVLRCLGVEECFECIFYCDYGIKDFVCKPEHFSYKVLEKTLKKKPHEIYFYDDLETNVICSKKNGWNGFLIKDDMYYVVSKSLEDKESHSVQEILDNEYAEIRVDTRIKTDLANELGLIYKCSDEIIPYVMTWDEIPMNVEAYVQSILLKKIVETISFYRRIGLESGLNAEESWERASMGVIMRAELHEEPTPPLKEEKREEDGAKKFKPKNKAPFISQGGTTLEEPTKNKNKESDLEEETKEVEENISKMVKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVA7</accession>
    <name>A0A4Q9LVA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0693p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000693">
        <property type="protein sequence ID" value="TBU12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0693p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="750" mass="89030" checksum="430B162A7C2A27E4" modified="2019-07-31" version="1">MKIDYVENEGIYGFEFKIESKYISSTFKSVYLLQNQYLKCVYINNSCKYYIPNILEISESENIITDLSTLDHEQENILTRRIFIGQISNRFLFRFRKYCTEEDAFINTLSFIELINILTVLEILGFKRTNNNNTFFKYLLLSSIMSKNFDFQISNTHLKLLETNIDILRLLLEYLFSVFSKFIYIEKMKNSTFLSLRSNSLAHDCKIILSFQFYLFYKEKLFNNNTFILAPERILHIEKVLSLAFTKDCICFFIKYCHIDTFWIRTAENALSEKIFDLIYTIKPKKLRKLVITDNLFNKKILKEIMNNGYFDITETLKVKSDLNLEEIQIILDHCKNLKRLVIECSIANYDVLVLLNEFAFNHQNIFLKYKCADFQIECERNIFLKNIPNNLLFYVQKFQESFLHCEACYSISYGLFRRIITKLDKNFSLEEHKRKFSICLNTKEVYISTIQDRFLEILRPTFFKYIFKMPNLESMIIENIIFTEILTSYILQSKKLIYLKLNNSSISFDSYSRCKIDNYVLRGLTMTNSIFPFNIDFINFLLLFHNLSFLKICINDIDESFESLINECTCTYECFKDRQEKMDSKLDYFKITIDKNITKGLPMIFALSHFFNFSSLSVLALEIYELDEKDAIVISNLKLLRKVHIRIYLQKTEIFLKRLTIILVNNMIKWIGLYFNSLDIMIFKYLVSLKSIGYIFINFKSLEENDLNLLNKARLSHPGNMALLCSTDGPVSLNVINFYYENNISYSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVV6</accession>
    <name>A0A4Q9LVV6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0603p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000603">
        <property type="protein sequence ID" value="TBU12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVV6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVV6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0603p0040"/>
    <dbReference type="OrthoDB" id="2196228at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051144">
        <property type="entry name" value="Formin_homology_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733:SF8">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="540"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="893" mass="102978" checksum="685A347F5988760B" modified="2019-07-31" version="1">MRRSQSLHAIDIQFRKILTEMGISRSRQTTLTEKLCPNSKMNMIVSMQSISKREENIVEYLQTLSDLNEENKKYDKNIIVSCNSSTPANVQSTLLKLKATLHNGSPALYELFDLKNGHQILTSTFLQNFYCCIIETVNVVVTQQPKMLSKFTEQKFLYKILDILCVDCLYEKISLNFKKSEIEFTCNTQPSFLHLSEKNLHLNNPLFSFLIFYLKNDKETLFEVLLAPCSQTFSSGDSYLRNIIFYVLNIPIITNELIFLFLLLEIRNSVVKFIFSSCNFVGKMDERIKNMSNKNEIKGFFDKIKEILNEKNKNLEKKNLENLQNLGNKNKESLGNKNNSSETRNLENLQNLGNKNKESLGNKNNSSETRNLENLQNSGNTGNNKIIKIIYKNETNNSDEILEINRGLFYCLKGLENKDSSMFCVVEIFVEYLLMGWIGTFEGLSSKICEDYVLVKENLKLLEAKIEMMEINNKKIQKIEQNPIKSNKIEIKEIPVEEKPNSGEKNNSKETSNVLINEVSSELKKLNIFNRPKSTTGPRKLPPRKSVKKEINLDLSTFGNKQFIPLRWTKSQNTAPLWKNLNCSKYVGLFSSSDFEPFEKINSPILQSGNLNSKKIKVITVFDSKKGNAISIALGRIKISDKDVKEEILKINETIFNENLVKQLIINFPSNDEILKLKNLNLNSIKNSNQIIGRAETFFLECLECTEEIHKSLKKIYLKIIFPNSSICLLKNIKLLLECCVLLLESQVLSEFFGLSLCCGNILNNNTALGNASGYSLESINVFKQIKGTNKESIFNLIKLKMKFQVKNTEIEILNKVLLNKLNYENIKNEMKDLKKVYEEGGFEYKKEFEFLNSEYEKMSVKYEECCTYYDVRIDEKFISCIFNIFREISEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX7</accession>
    <name>A0A4Q9LVX7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1695p0010</name>
        <name evidence="9" type="ORF">CWI38_1026p0040</name>
        <name evidence="8" type="ORF">CWI38_1726p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01001695">
        <property type="protein sequence ID" value="TBT98568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001726">
        <property type="protein sequence ID" value="TBU10486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001026">
        <property type="protein sequence ID" value="TBU11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1695p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1026p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1726p0010"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT98568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="301" mass="34245" checksum="F39D97BBD0595BC6" modified="2019-07-31" version="1">MIDRFLERLFKCEYLEEDEVKSLCDMATELFIKEPNVLSIKAPVTICGDVHGQFYDLMELFSVGGLPPVTNYLFMGDYVDRGFHSVETLSLLLGLKIKNPQNIFLLRGNHESRQITQVYGFYDECIRKYGNSNVWKYFTDLFDALPLSAVVNSDTFCCHGGLSPSLNTIDDIKLIDRHVEVPHDGGMCDLLWSDPDEKAGWGVSPRGAGYTFGQDITKNFNMVNNLKMVCRAHQLVMDGFNWNHNKGCVTIFSAPNYCYRCGNMATLMEMNEYGSHEFTQFEPSPKSSDDVISTKIPDYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVY8</accession>
    <name>A0A4Q9LVY8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0758p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000758">
        <property type="protein sequence ID" value="TBU12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0758p0030"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="25231" checksum="0FE836C999A16188" modified="2019-07-31" version="1" fragment="single">SSKRIRSHSVQEILDNEYAEIRVNTGIKTDVEIRNNRPDIFILDKKKKKITHIDVGITCQDSLQIVKTEKLGNKNCSVEITLYEMTWNSIVNKYYKSHLKRLEILMNIEAYIHSEGLESDINAEESWERASMGVMMREPTNNINEESDLEEETKLVKENIIHNDIKSDNVLIDEDLNIKISDFGLSCTNDEPCKIFLKLKFEENEGKYYHYSPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWL3</accession>
    <name>A0A4Q9LWL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0666p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000666">
        <property type="protein sequence ID" value="TBU12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0666p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="44394" checksum="61AFCE0A44A1304C" modified="2019-07-31" version="1">MRKKKIWKEENRERRVIATGLVVGYSLTKTDLYFNLRENFMCQIKKILRRKAALVAAQVCYDENENIESKISRGVVSQDILESTVKIDDLLRSINHLLFMEDQKLLFKIETLKEITKEGKIFMRDEEMVIKMGNATVFLEGISVCKYFEIIDDKRGILGVRHLKTLNARNLFQAINIHAIILPNYHTILILYELADYSKLDDAVRAVLKVNNVYTSTKELGRGSHSLVSVNDSSRWSKKGSVRPPDEAVFFYIQDRNVLWGAEDVCQHCNTSRKTVDHLATRFQEILNKEYAENGERTRIKTAYDLCANELGLVFNCGVEIIPYVMTWDGIVQKYRKNYAKRAQINMDNKAYTQSIVVKKTSGSNAEEGSRMQEKLTPSLKQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWT5</accession>
    <name>A0A4Q9LWT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0626p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000626">
        <property type="protein sequence ID" value="TBU12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0626p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14342" checksum="AC01A94B2A89CE38" modified="2019-07-31" version="1" fragment="single">MNVEAYIQSIALKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX87</accession>
    <name>A0A4Q9LX87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0579p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000579">
        <property type="protein sequence ID" value="TBU12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0579p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14308" checksum="8213008F327DB8AC" modified="2019-07-31" version="1">MTWDGIRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEIHKQPIPPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPSTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXC5</accession>
    <name>A0A4Q9LXC5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0971p0010</name>
        <name evidence="2" type="ORF">CWI38_0793p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000971">
        <property type="protein sequence ID" value="TBU00546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000793">
        <property type="protein sequence ID" value="TBU12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXC5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0971p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0793p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="134" mass="16259" checksum="D00C8C86600EBBB2" modified="2019-07-31" version="1">MDKNLKNAIYFNKNEYVETIVGIFNINNNFFSVYDKSNEKRHIFIDQNLCFKEIKYKNLNIFRFKIPVYLESNYEALSNHFNSEKLKQLFYLGKILSFNNLYIFRLFLSIKPYIKLIFAKTFIDILKLLDHFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXH4</accession>
    <name>A0A4Q9LXH4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0441p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000441">
        <property type="protein sequence ID" value="TBU13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXH4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0441p0020"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21348" checksum="305373BEE07779AF" modified="2019-07-31" version="1">MNENPIIQDINEPRIKLELKNNKLVNITVATIYELLRDIKDPEHPNTLEDLGIINKSGIKIGVIESSNIEEIESSVEKQDFLSNNDKNEMFLFKKGVSITDYGLPINYIDISFVPTIPHCSMAALIGLSIKRQLMKFVDEKYWIRVYIAAETHVNELALNKQLNDKDRVMAAFENEAIVDLIDMCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXR8</accession>
    <name>A0A4Q9LXR8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0667p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000667">
        <property type="protein sequence ID" value="TBU12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0667p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12677" checksum="DE7361AFD1E0A980" modified="2019-07-31" version="1">MRFSKKQKFFLLAGLGTAVFCGIPIVISIFIGRKMRNQLLKEFNDFKELPLTKILKNQLKDNNDIGFPNFKFNGPDVIGICYSCKEIANILTFLRLFLEDAGKNDAIQKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY67</accession>
    <name>A0A4Q9LY67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0342p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000342">
        <property type="protein sequence ID" value="TBU13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY67"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0342p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="30530" checksum="350EBDC52A9E81BB" modified="2019-07-31" version="1">MFLISVTKVNCLNYPTRNQNNIAAMFIIEENPDKRVSSLIEENPNPNKIAQKKRRGRKFKLFDNLPVMKIQIIATNFNKPKVFREESTKDESKENNNQIEEKDNVQDESREEENDENKYDGECNIENSDEKDRVKDSDTDNKIERDKENNVEKNDEKESLQDKILVEENEDNENSSETKSGDCDENEEDTSEKTSEEAENNVEQDEEEDTYINEDNQKDLTKEEASDLYEKTDKVQDLAMEENSNEDTNSKNQKELLEMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY89</accession>
    <name>A0A4Q9LY89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0669p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000669">
        <property type="protein sequence ID" value="TBU12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0669p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="758" mass="90334" checksum="78D7405585EC1BAB" modified="2019-07-31" version="1">MSINSNFIAAKKFIYLIETNKDREILFYEEIEDKLETIGIIHESFYMNVLNNSNRKSENKLHRVFTYKKNNFVNFELLKSVLEYPTYENLITRIECNFNLAYILKSLNDISSIPDEANIDYLNCLLLTLRSLKAIENKNISDFIRGISFRIFFKQFTNNSISEDLKLGDLFSQNELVSWNLYVKKLLIGTFLDYLMIKHDFIDENLVISINTKRIIDDTTFNKHIPYKSLLINDHKLFCVLENIFRNRNILYTFQILLHELNIKSLILDAFKISAFRDINHALFFPLRIFKAIMISNFSQSIRIIINELDLAINHNLEYFCLKNMDIDDEDFGYFLQKWKLKGLVLDNVETNNHFIGAYLTTNETLEYIEFKNVEMSFSWWSCFAKKQNTYKVIFSYNSNFEADNFIQEFMKLDSPVVVSHLEINFHRYKICKKFGRILQYFPYLKILNLSFYQSEIDFDKNLLEAIQKMGNLESFSIDIDRLNCDFFNCMFQNKKIEFLHFNNSYKHRQSLDLDSIYNYKVLSELYLNILHISENTLREICKCENLELFEVKDCYIGSIAGLRPIEFKSKNLKILHLDIRNLKIFSDLDILSELNCLEGLSIFGSKSYFCGLAYLNKNWDLKLRTFSYRNGILQINDLNRIKQFMVIEKLDLYKCKFIDSGFCQFGEDCKFLVSLKCLNLEYVKLNSNDIQYLKSFINLKILSIHFSEYHKIRADFISIPLKRFHFSSKKMFEKRNMKNLLRFLREENIIFDFINIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE7</accession>
    <name>A0A4Q9LYE7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0311p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000311">
        <property type="protein sequence ID" value="TBU15520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYE7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0311p0010"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="62"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU15520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="362" mass="41035" checksum="76B5962FABA05D77" modified="2019-07-31" version="1">MGIQDRIKEIENEMARTQRNKKTEHHFGVMKARLAKLKQDLLIPKSIISKTDTFEVMKDGDARVSLIGFPSVGKSTLLSKITSTESKAAEYEFTTLTCVAGKLNYNGTNIQILDLPGIICGASQGIGRGKQVIGVARTADLILIVLDPLRLSDKKVLENELYSMGIRLNKNKPDISLTITQSGGININFLIKQTNLTEPTVTGILKEYKINNCIMIVREDVTDDDIIDILTNRAVYVPCLFCYNKIDNLTLQELENLNLDENSFALSSQRDWNLEELKEEIWYRLGIKRVYTKRKGCFPDLNLPVILRKSCTVKDFCKNIHRDFVDNFKFALIWGASAKHNPQKVGFNHELCDEDVVRVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI9</accession>
    <name>A0A4Q9LYI9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0610p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000610">
        <property type="protein sequence ID" value="TBU12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0610p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="166" mass="19400" checksum="72143D5FA5272A97" modified="2019-07-31" version="1">MSLQNESNTHLMLVCQVILKRVTSVPERRNSPSTIDFRELEVDNDDKNFVFLDEVGPAVVIRLSKGCNRQGESAYLSVTAVQSRNILKVEAMNKYGSIYHKIHQRDLNEEDFKFSIKISTPIFVIYNSRIHHYLELNDDEEIASYRIKYLTRYFPFFNLIENAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU6</accession>
    <name>A0A4Q9LYU6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0272p0050</name>
        <name evidence="10" type="ORF">CWI38_0569p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000569">
        <property type="protein sequence ID" value="TBU12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000272">
        <property type="protein sequence ID" value="TBU17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0272p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0569p0020"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="25937" checksum="BCDC21B9D89C1CD4" modified="2019-07-31" version="1">MEDSVFKSVKEIELTKIDSDIIKNTIKPFYGTTTLAFIFSGGMVIAVDSRATSGPYIASQTVNKVIEVNKYLLGTMAGGAADCFYWEKLMGIEAKRYELHNGRRITARAASMYLSNSIYPYRRYGLSMGTMICGWDKNGPGLYYVDNDGRRLEGKLFSVGSGSTIAHGILNSEYKFDMSKDEALSLGKRAIFHAGHRDAFSGGVVNLYFMDCNGWEKIGSYDISQLYDEIMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW0</accession>
    <name>A0A4Q9LYW0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0285p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000285">
        <property type="protein sequence ID" value="TBU17605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0285p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020254668" evidence="1">
        <location>
            <begin position="18"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="606" mass="71556" checksum="1DC457FC89750E82" modified="2019-07-31" version="1">MLFFFLLTKEFIKCSTATNEDNQLSISDIPHTSTNHIDVKYSQQLSKKVDIEKRRKQERLSELITDLTKRKLELDSLETEKPLCTQSFLSNSSSDNLTKTCEIDKSVREDQEKMPVLSDKIDIMTPIDLTYSDPHSIHICNLEKRKLIDSEESTQFGLKNSKVSRLAVNQAKQGTQKTTEFDFEKYITEQFEGLEIPVVVAELSINPDSNLSNLDDRIRNFKDNIKKFTEYICGKTSNTKHGDSTNYILTNQNIFSKLEQEKLFIQNNFSLYNSDHIERVFLFALSLVEFEKNFQGDNKPDLKAFDLNKAEFMDFEKKLKAYQGIFSIHELIVIKNIYNTCFKQKTQDGYILYTYFLFEIFFTNMEIILSNFERIPTKPKNDSDNIKETYKRKPEVINADIDIIFLKTILLRVIYGIKDGPIIAKKYTLILVLDFKKIFTDYYYKSPETSQNTRIKMNILYTDILCSDMPDGNFEDFAKKLNNIFYFKWDSKPDFLDLNNFEINDLSKIKSKYDEFIEELLKAIQSSDNTYRKKIKEGVKAKEVFELYKNINVWGNPKKKLVQLYFLDFYLCYLRKLLYPHYQYEIYMSRNSWNSRLNKFECINQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYW2</accession>
    <name>A0A4Q9LYW2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0583p0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="PITK01000583">
        <property type="protein sequence ID" value="TBU12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYW2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0583p0030"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="6">
        <location>
            <begin position="363"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="986" mass="116582" checksum="6BE18FF1234C48DC" modified="2019-07-31" version="1">MYFYLLHIKQLNDSSVMLYGHKIFSEEKPKTFNLSELKTERIKIKIDKIFSPVYFYGKDLDSLKKEISDFCIKKNILFEIEEITKKNYFNESLPENLKVLKLCSNINFMTNTLKSTNIISSFKEFTTPLENIIISKKIMGPGLIYISDYQENMHGEISVENINFINFLENTEFPFLTYSYISVKIIRNEIIEFCMKIIYNKEIKNYFGFVKGTNLRENKSYEDFKNNYNQISQFKNEFTSVEMYKNFEQMKLKIKEILISEKVDICIFHNLHENIYKNYISDEIIICDLFVVAPDFIKGRDYSLEEICKTLDIKLPNKNYKKSLEIESFFELERNCGIIIESFKILNILDLYKQMTEISGNLLSRTFQNQRAERIEYFLLHEFYEKEWIFPKKNKLFLNENEKSIFFDSNQENDRNKEEDKGYKGGLVLNPNRGFYETLVLLLDFNSLYPSIIQEFNVCFSTVGIFKFNEKNIENDLEICNNSLNKEVGILPKVLKRLTERRKVVKELILNSKNKNEKKNLNIRQKALKLTANSIYGCLGFVNSRFYNLKMASFITFKGREILTQTKSIAENKFKLNVIYGDTDSLMIDTNLSGINSNYNKSIEICNQLVKSINILYKNIEFEIERVFKKLILYTKKKYACLCIDSKGNSFIETKGLDMVRRDFSKSTFIISTEILNILLMDMEVKENYKLVVGTELENMTENIFFKNNENKKIAELILEKLVDFKDTFEQQSVENFIINAAFSKNPENYPSTVFPHVSLALRLKENGIIYKKDDVISYVIGIGDKNTHVSKRAYLPNERYKIDFNYYIEHQVLPSLFRLLSLYKGIHLENINKIFGVIKPIKYLPTKNITFITKCCETVQEASKNCKSCNKEIHINFYINKITEILRKEISNLYLTDYKCTECNLKYDTYTTVCYNCNFVNKYQPKNYEFDQFLYSVYVTFKELEMNEVSNLVLKCLNFSEYRKIDLEKYFGKEFMNYCENKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ07</accession>
    <name>A0A4Q9LZ07_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0253p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000253">
        <property type="protein sequence ID" value="TBU18112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ07"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0253p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="555" mass="65736" checksum="EBE8B6D089D436CC" modified="2019-07-31" version="1">MFFYILFSVAAFPPDNDFTNLSEDPITGDHIRLEMPYNLQAKNTEIENFIYLFFSLGTKENMDGLIRIASFYSSELKKYTIKEIHPFLTHFTTFICSIVYLKKNYGGFEKFRPDFLFNLISFGKFIEMYKTNEATKMAITDLFGNSLDNYIDLKSVEIRDWGSPPINHMYNAIKDMFRHFFPGLHQKNAHVKHFVYMLNFRKLQYSLSRGTFEFFLCFFYSLVRFKAFEGEYTENCSVKYMLPSRKTVEKIKEDVAKLSRLTHNNNNNPEYKNILGYIFKPFSKNILKKETGFFELFDHSENFSLNNKLEDSKFSQDFVEVFCNEEELNKIKCLNKFIKEKTKEEYHDYISAVICLEAFNLKRNFSEGNDITRIIMDILFLTDVLKTKFEEIKTAENRREFRKIFFEALIKELGKRGIKLSPDTEFDFLNVIKLPRTSSLLEMYYFAELLYGNIARRNFSCSLQEKLNQKLNTKEKDSDFTKTNYLLYVFNNEISGLTQEELKNLFSAQTPETPVSKTTNSKNFGFDKIFFYIVLPILCFCLIIIGAYWYIYMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ32</accession>
    <name>A0A4Q9LZ32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0542p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000542">
        <property type="protein sequence ID" value="TBU13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ32"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0542p0010"/>
    <dbReference type="OrthoDB" id="2404674at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="732" mass="86280" checksum="1D7CDC4FC9E939F1" modified="2019-07-31" version="1">MVELDKLRKKLDRTIQSYHDKRREKELHKMKKVHEEITRISRIFQKFQNNLHTDILQIDVFEKKAGDIKRKIESRLLHFKDYIYCELIRYVEFKEKSEKYIFEGNESVNEIEQHKNVVLGEISEYFSEKDEEVKICMFKVIKGNLKFLKNIILRNEEQLQEKKINSVNKMKGNQVNEMKGNQVNEMKGNQVNGDLVNRNQENQVNTNPVNTNLINTNLINTNQVNTNLINTNQEYQENEVRTDEMSNNQLNNQNIKLHENPSNNSFFDTNICFSKHKEEEIKKEIQINFERLFSNIFDITLFTGEFMEQINENKEESLKTKVHPCMHRFISSSDEFSSKSKFNLENKKQKSKIQIYSNEDKTNSIVEFLKDYYYRTNQSSPTKPNTMEMGRGEGIEGEGIEGGEMKNGEVREVTGNIQQDNTLQENILRDNILRDNTLRDNTLRDNTLRDNILRDNTLRDNILRDTHPPHTSNNLTTHTQETNQETKQETKHRLNYKIHHLLRILSLESHKYSSELHNFLGIKIKEIENEKIEDKSLSIRQTEINQKIFKLFTKFAKNLQINEVSLYLDRCTKLLYILNQDIKDKQSSYNIMFLDSVESIIKQGSLQEDKRFITLIDELLNKISEKETPLFFKVGVNLELCKKYVKDIVSLKELLNKRKGVNDCSINKRVLMTICKYKGVKGVNDNSVNIRVLMTVFINKRVLMTICKYKVLIHNTSKGVIILLIDKRVLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ83</accession>
    <name>A0A4Q9LZ83_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0235p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000235">
        <property type="protein sequence ID" value="TBU18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ83"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0235p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="63" mass="7236" checksum="617D237C206685E8" modified="2019-07-31" version="1">MPEEIAGEIVEATEENMSLKTIKNRDYRKEIRAKRGLKAPNGVYEKCNLATMCRKGTFLVFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ90</accession>
    <name>A0A4Q9LZ90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0538p0010</name>
        <name evidence="1" type="ORF">CWI38_0539p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000539">
        <property type="protein sequence ID" value="TBU13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000538">
        <property type="protein sequence ID" value="TBU13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0538p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0539p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43373" checksum="06ED4898FD0A212C" modified="2019-07-31" version="1">MTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLEGVSVYKYLGIIEDSRGIPTLERLCHTRLNAKNLFSAINQHAISLINYDIGVLRLEPADFSKLDDAVRAVLVKNKIHLCPGCKERLYLPRTELGRGLHSVELRSEHMLLQLDDCMEKSKAISTRRAAIFKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRPRNEALFCYIQDRNVFWGADCVCQRCNKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLYLLFLNRYKFNVEIIPYVMTWGGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTSWERASMGVIMRSEMHGEPTLSLKEAKRKEDESDLKEETVVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ93</accession>
    <name>A0A4Q9LZ93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0521p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000521">
        <property type="protein sequence ID" value="TBU13130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0521p0010"/>
    <dbReference type="OrthoDB" id="2192073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="25964" checksum="C38E3346C6B63362" modified="2019-07-31" version="1" fragment="single">MDYNVITANMKFYGGIFDMVNRDLQPYGVQVRGYFDNLSLDDYKVPYDKTKCMEGSPSQARSAMSRTFIQAKEKGQLGNRLLVFFCPNLLMTPPLTSILPFGTCDNIIGFTFGEIHQLKTSIYDSIFRMISRVKYKDMGTVNTSFNSELCRYTDNCISNSETVYGEYIRDLKSVRHLGTEEYILKPGAKLKIHDPNDDTYFLKAHGDGFRVFPTEDYSNEEELWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZF9</accession>
    <name>A0A4Q9LZF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0217p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000217">
        <property type="protein sequence ID" value="TBU19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0217p0020"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="79" mass="9090" checksum="AF7B978A58CBC7C9" modified="2019-07-31" version="1">MKVLGVLCFSDKILLADNYRKVEISSRNLIQRVETEKPRKYDPFANVLGLIYKCIVEIIPYVITLDAIMTNTIICILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS5</accession>
    <name>A0A4Q9LZS5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0202p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000202">
        <property type="protein sequence ID" value="TBU19785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0202p0050"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15530" checksum="321CB06E5F0745EE" modified="2019-07-31" version="1">MVSGSNIRLNEYLTKPKVENSNDLHLALSKHFLREKGFTKKNLSVNELKQEFKNIHCISFDTISCMITWDGVVTKYHKKYPKRRQTPLNMEKFIQSITIKTTVELFPLIDKEDLSLNLMAYRAEDASMSAFRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G7</accession>
    <name>A0A4Q9M0G7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0133p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000133">
        <property type="protein sequence ID" value="TBU20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0133p0040"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="91026" checksum="0ECF6C534A2B2D8B" modified="2019-07-31" version="1">MNNFDDLKLYFMFNMLYYLILFQYIIANNFTYSFERNGNLEILFFRINKEESAFNTLAPNVCDLYISFHELFESNHEKTRVFTYEKNNFIGFEILNDFITSSKSLHKYERGIIQCNFELSYILRLSKDIAEIPCVLNNYQFSCILAVLKRLKAVENKRLFEFIKFLIITDFFLYNNCLNIQEIFDWALSLEINVQSSNIILSIIFNFLMLAHVFYDGNLIILENTSEIYDLKVFDTQVLYKSLLVNNIKVFYILENALKNPQILETFKSMFSMLNIRSIVLYNNQRSKILESDFEFPMFKIDGIKSITIIDFREFSSSLFLKRLRKHIRKDLEVLKFQNTYIDISTLTTILKDQRFKKLVLNNGGIPVFFHLSNNFTGLNQSLKCIDFRNVTVDLDWWKKFFMEANVDKIIIHFSIQFAQDAFIMAFGFVPFPSSNNVTYFKVIFDNPQIPTSFFGSLSCLKNLRTLKISKYLVSEAIHSRLFEVIENFKVLKCLVLRKYGYSKKYYISLFKNPAIENLHLESIFQDSEIFIVDFLNYYSSLTKLVLINIMICQSSFIEIFELKKLTSLTYRSCIVEPKINSEPFCLKSKNISLLTINSNNLNDFKTIDLLSNLETIENLNLSLCNLPSGYLSKLSLLCNLSLKILSYEFNSLNLNDLQRMGKLETLEELNLRGCKFIRINFCKLNCECKFLYSLKKLDIWLVRINNEDLKFICNFRNLRNLTLTLSGLDLYALEDCPILLKIYQFSTHVNIADRGFIKLFGCLNEKGIRVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q6</accession>
    <name>A0A4Q9M0Q6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0120p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000120">
        <property type="protein sequence ID" value="TBU20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Q6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0120p0020"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="653" mass="79670" checksum="1C5F6F7A56CFA146" modified="2019-07-31" version="1">MDITNQYKKEKIEKFLKVKNKEIAEKQISVDEIIKSIDKERKKLNQNTFEKKNKCAIKNLNLQQRNKYEALICKYRKDPGVYIKYANLEENFGEYNKARSVYERAIDFNYSVDTLWFKYIDFELRNNFLNHARNLFERFIELHPGNEKAWLKYINFEKSKKENENVRRIFKMWINKITNENNYHYYIEFEIKDKKIDKARELFEELIMKCKTINNFLKYAQFEIKQKEFKAAENIFNSILTDFKEKEITAAFFIKFSDFFINLNKKERAVDILKKGNNLLRYSAELIDKTLETTYFEIDNLDNLLIKRKFAILIQNSLEKIFYCKYNEIEIHKYFYIGSFNLKEMLKNCNEEEEKEISCKIYTNLEKLFYNFDFNKFMSSKFEQIHIYSLLDLFLDVANIFEKYEDLKKVEFIYENVICFIIKLGINYSKVFVEYAKYFERANKISESRKIYGKAIGLLPTSEVFENYLEMEKKLKEDDRVRKIYEKYLENDLENGLVWLEFSKWEYKHLEMYRTHSILDLGLKYAEFNRKEIFEFYIEIEKKIDCLKTCKLYEKFCNEFPKEENYFSFFEFLKENQFNTILDKKIFQILFKNLENNSIEFTDILHKFNFTSQERTQFINQKTLLYNEKHSVKPINKISDLLEISKKWKSNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M175</accession>
    <name>A0A4Q9M175_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2 14">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_0183p0020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2 14"/>
    <dbReference type="EMBL" id="PITK01000183">
        <property type="protein sequence ID" value="TBU19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M175"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M175"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0183p0020"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 14 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="198"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="52656" checksum="CC14D5FE15048D67" modified="2019-07-31" version="1">MKNIATKNLEDQVSNTTDELEVKSRDKDSIVNNEDILIEKGENTVNIEDEIIHLDQKESRNITNTINVEENKKDSNKNTHTSSSSMNLEENQKDSNKNTHTSSSSINLEENYKDSNKNEETSSSSINLEENLKDSNKNSKNIPTLVSLEDDNKESLYAKKMRKLNSMESRAESSRVNRKIATHYDKIQKKTISERKNSKIINIITTNNFIKTILLNKYIKERMDVLDMGCGKGGDLQKYKYLRIKNYLGCDISEESIKEAEKRYLNIKDKYKAEFMLLDVYCQEINLNRSFDIISSQFSLHYGFRNSVTIDNLVKNISLHLRENGYFIATIPDKVTLLNRLKKYGNNYGNEFYKISFKIEKNEELSEYLFTLDGAVDSCPEYLLDCEILKSKFKNENIHLIEEKSFLNFFNENIRINKNLYERMRVKRLSIDELKVIELYKVIVFKKTKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1M8</accession>
    <name>A0A4Q9M1M8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0049p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1M8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="264" mass="30049" checksum="BD48F5942E5EB6A1" modified="2019-07-31" version="1" fragment="single">MLKHVKIRTRETKSEEDGKSDIENNRVGLKDETNVFYEKPTYVEFEKIDEELDDHNLVKRCNSNDLSQVEIEKGKSPLCANLIQYVGGEQSLILDENAQETPSTISVTDEVEKSNYQKQNNMIYGTGPQKIEMLRTNSTDRSEYHKSNSIYETMLFSKPGLIRQVRKRSFTNRNSFGYQTQSLDRCSSFLHVLGTKSRIEEPLGKELSEVQKARTYERSALLVESLTGINLENQTNGNHIDTENGVIGLLNTEKTSTIRNATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1X5</accession>
    <name>A0A4Q9M1X5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0247p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000247">
        <property type="protein sequence ID" value="TBU18237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1X5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0247p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="778" mass="93710" checksum="F39811E51485ECAE" modified="2019-07-31" version="1">MREGNKIVTNRNLNLNSLLFVLLITLKVIFPQKTIAIHFYGSVETKIQRDSLNNYIYSEVLSQSTLEKRDISLFDIKNKISQIFIIDINIFPLKFLNEDEIPENQQYNIYINNNLLNYDDFVYFYNIVMSFPYLIENINECKYLKIFRIIDIFKFKNDKLFIDFIRYMLASVVFNLVDLEKWNVFSKTKNVYLVNDAISKKVILEFFRLYFIDNRTSNKIRDISRILESIKLYKFVIINTKEDFLYIYNDILQEILKIHKNIKSFQKIFNTIFKIHIFKRLLLFKINYNCKYNCLLDLCLFKNCDEIFLLECLNTEILIQKIYEFRKFIPLKTLSIIDSKFTIKDEISWFETLNVEKFYYVVSKYNSVTKFSKFGPESPLCNIFYKFKEQIYNKENESNIYNRDSDCPCYDQNTRIDLKCHQEKSKIERLINIKFPFQEFVYMEVTNSFIKFSFYLMNYKEFQNITIEFSYTNLKDFNLKKSEILNYREIYTNIEILTNIVTMRIYNSILNDIFLSKVLLFPSLKRLFISKSEIIFSNEKVEFDRNYKIESFCCNESRVNNKKCVFDFIYKLDALKEFEISCYTQITNIFEPKFYDENLIMINVTNLKYSVKYYNNDYTPFYSIFPNLLHFDFSFECPEGTLYNIFFKKNFVYLRSLTFNDITVGIKDANALKDLRNLTLLYFNENCKFTEISFCNLFDSNNSYLLEELRFPNMEYTYCDLQFLMRLKFLKKIYVHGFINKNNIIFLLKVFSSGVKITIKNVFQFKNQIVEGFGLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M217</accession>
    <name>A0A4Q9M217_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0114p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000114">
        <property type="protein sequence ID" value="TBU20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M217"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M217"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0114p0010"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="22685" checksum="6EFD87B000793D57" modified="2019-07-31" version="1" fragment="single">MQCYQSISSKYGIGNKICYAHCYRETLAIYCLMVNRKGIDGCLHNTTPSNNNQGKETESVFSDTFLTNTSLVVNALDNIEARLYADKRCITNKIPLFESGTLGTKGNVQVVIPYKTESYSSSRDPPDKSIPLCTIRNFPHCIEHTIDNFEEKIISISEYIKGDNYMDSKLEGDNDSSSNYRGYPVNDSTSKQDPVNDSTNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2C4</accession>
    <name>A0A4Q9M2C4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0011p0150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2C4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2C4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0150"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="31258" checksum="2A6A11BF68C7C035" modified="2019-07-31" version="1">MEFKDKFDTFIMDWKTPVISSFLYMAYVQYENKRISQVTPPQRKKFSLLTLMMVLHNLILCVFSGIVFYKTYNILLDCYKKSTFYNFLNDGNKFLYKKMIFWTKLFYLSKYYEIIDTIILHVNKKRTSFLQMYHHAGAIICCWMLAKCESHVPWIFVVLNSFVHTIMYAYYSLTCLGIKTKYKHLITKMQMTQFVMGNIFILIHIFKGDLLKNENIFTSFKVLALLSNVFYVAVLFGLFNQFSKQTYSKRIEERKKPIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Q0</accession>
    <name>A0A4Q9M2Q0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0200p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000200">
        <property type="protein sequence ID" value="TBU19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Q0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2Q0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0200p0030"/>
    <dbReference type="OrthoDB" id="5534248at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="409"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="913" mass="107267" checksum="95F6AE1E8478784A" modified="2019-07-31" version="1">MLGIAETWRDEITCLHEDYKIIAIKPSIKILNRNSNKEGMIVIGRKEIIFSNIYELTEFGISIKVNSTNLFIFIYRNLSSNLTNIILDKLYEHIDNKIIVIGDYNLEQHKEMECEILDRHILFGLSEINLKTMTYKHGEKTSCPDKVFSNITIFTETKEIPQINHKLIICEIPETILPKTPRYKMNLLKDKAIAEKIKIQIQKYTNNCKLLLKNLEIDPCCDLLHNIILKSTRTIQIRPRQAPRLNDVIQHIRLTREKARKLKQPVYNTLCQEVKNLKKRFTDNDLPASRTKHIGLDTCEFEKILKFHGSATPKTNLDSNRLLNEFVIDSQYKTTEKTIQEINEYYNDKKTKRQMSTVNKIIEVSIKEVTDCISTLKSGKSGGLTGIRNEFLKICPENFIEELTKLYNRIINTHVIPNSWKSHKITPIPKGKDEFRPISLIEKTRKLFEKLILSKFDARLHKQQTGFRTKHSTLNHALCLDTLLRHSNGERICVTLDIKKAYDSVDRNKLYTKLLIQQNFSLNDTELIASMIENNRYTTCGAEDSQTSKTASLGLPQGSIISPTLFNIFINDLVEYLPKHLRSFIFMYADDIIIYGNQIRTIQKIIDSLVRHANHNNYQFNPKKCFYNATKEHQISIYGTRIEKQNPLKYLGFYFNNRNADTKQTLKVLRQRAVRAAVITNKVMRKGIFNTDEKLHVLKLRAYKTFVRPHLDYFSQLLGCNKTFTDESDRIQKGILKYLFKIYYRTPSSIIYSILPIENVLQRCQRLRYGIAHKILRMKNTIVQYVYKKNFSKNLREFKNYYETINRNYSGDDFLTKYKKIHKENLRINFQTFSWNETLKLYNFKQCNRLNFNQILEIIHPVHKRQELADILIKYIQINIGLPTHVWLRDKSEILKGLKDDGVNTHKVIVNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3V2</accession>
    <name>A0A4Q9M3V2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0034p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000034">
        <property type="protein sequence ID" value="TBU20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3V2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0034p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="51077" checksum="3B0A7EA1AF548742" modified="2019-07-31" version="1">MVPPTSDLYLCFKKDEMSTSENMNDFFQLDLSGFALSREYFNSTTYISRYHSSEFSDIGYINKNTLNLVSTFRKIEKSIELSENQRFLDMGDIKYAEWKIFYGFLQDISYDDTLKKHRKIFQESITESLYISCSDPISKILRIVGNTFLENISGVFFRILKIRKVIIHTYILQNFTEIPFFEFISHSIEEITSINAGYNLDQLTLLEDRDQFPNLKKITFFVFTSNMEYCFINYLSICELIHLYCKKWDTKIRIQASKLKVNKIISSEVINFNNNFYDYSDCAHPYLLRFQNDIESLKICCLEKYVLADDIVNSLENLFKNIEISINFVNQITFDDCVFGDNMLCFTASDFEESKIRVKIISDYDSEVNNLSEHLQKYFFELEFVLENHIRGIRRKTCFYINENKTKYMMALRKQENIPLCFQVKDTAMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M491</accession>
    <name>A0A4Q9M491_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0085p0060</name>
        <name evidence="3" type="ORF">CWI38_0297p0030</name>
        <name evidence="2" type="ORF">CWI38_0652p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000652">
        <property type="protein sequence ID" value="TBU12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000297">
        <property type="protein sequence ID" value="TBU16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000085">
        <property type="protein sequence ID" value="TBU20356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M491"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M491"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0085p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0297p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0652p0010"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="332" mass="38503" checksum="295A125E556DBD36" modified="2019-07-31" version="1">MMALIAQKYYGIRKEYIKKYVKKCEACSRFNSLKTIQPVYINHITKKYDLFMMDCVDLGRYSDQNDQYSWILNPINKTSELVKDSLKFLFNNFGVPVAIQSDNGREFKNALLEAFLTDINIEIIHKRLRTPKAKGQAERVNQTIKRWLAKKLHETDGRRWIEHLNNVVCAYNRIIHSATNKSLFMQFFGQPGFNNPLSRSIIVENEASMIVPAIDIDPDTVLAEENAADTQYILEIASNIRSDVAKNFKKYRERIIESNNSNKLKRDLSIGDQVLIKKKDLDMNTKIKKAPFDSFYDNSVFTVIAILMNNMIEVKNNDGDIRIVFRGVIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4M9</accession>
    <name>A0A4Q9M4M9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0057p0110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4M9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4M9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0110"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="691" mass="77363" checksum="23A7E7AC73503C30" modified="2019-07-31" version="1">MLALTVSLSSFILGINLTNINTAKQVFSTCSTQNTIIKSCILTTTSQWAFLIALLSLGAPITALFHTTLFKYFYILISKHIYPNPSSYINKNKENSSIDINRDRYDRYDRYDRFDRFDITNDNTTTTTNTNNTNTNPTTLHILLLANLLYITSTILFTTCTSYTILCISRIITGMAVGLTSISVPSFLTNTSKFIKNYHQIFIILGIFFGQIFSFIFYTLETWKIPFYILFLVIILHSTLLYFKKIEISEYNSIGDCVSIVNTVDLYPNPSLTLNKCINNKDTKKDCNNRSDNNNCNNCESNNCDTNNHSNNRDCNNSSNNSSNNSSNNNTITNTTSNNTTPNNTITTNTGNTLVISLLTHILQQLSCINGVIQYTSLLISNNIPYTLLIITINITMIIFTLISILLKMERKKIFLISNLLTLVGLIMLSSSLNVLISLFVYLIGFTIGLGPIPWQLVGGNSKVGDSVNESVDCYKGVNDSVDNYKGANDKDMVVGVNNSVDNYKGVIKSVDGYKGVNESIDGYKGVIKSVDGYKGVNHKDMVVGVNNSKDSYKGVNNSKDNCKGVNDSVNGYNPVNNSIDNYNPVNNSTNEQHPFNNLSDNYHPVNNSILTQHPFKNTLNTYNPVNTKTKCYSNTVIAKTCVTVNWLTCFIFSYIFPITHDYMGKRCYLLYACICSVIYTYIYIKGDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Q5</accession>
    <name>A0A4Q9M4Q5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0005p0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Q5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0140"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="9210" checksum="03AEA3D18D120DC7" modified="2019-07-31" version="1">MEKQEEENSRNKKNKNKNKKVTFLEENLEANEKYFNECSFKEIEEPKTPYNREEETDFDSFSTTESTDEDSGYVSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M586</accession>
    <name>A0A4Q9M586_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0027p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M586"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="538" mass="62965" checksum="87314417342B52F0" modified="2019-07-31" version="1">MNFLYLMILFDYMVFGSKKNAKKNKNSIRISSCDRKTEEKAQHLHSIAIYIKGYKSLPLRIKNLKEMNYIAKLYSKNYVSKILSEENLKNNIFPKLVSKINEYDHSIFEKDNRKIYILCCFEIHNILREKMTLVFHSKFDSVTNLFFDKIFESIKNIKVSTLDEMETKMSNANFSKIEYCIGKIKILTKESEFTKSFILNLNEISSAESNFIKGYVFNILFKILNIILLNCEDYQITSTFLEKKDSTALNLALDSNDQIIFTKGKVDAKFLEDGRDNVVIFNEIGRLIIESSKFLTKEMTDLDFSEKTRQNLIFNGLDSCNIFELNPEDAIESVRKKISVFLKSNILRKLKISNEISPKTKIYLVIDLNKQIIQCSEFFLLYLHGLKSSLDRSKIFEELNDLNSIRNILSENNSLIFKYIQVILNVFHLILEEIDKKFNSSYEICLLFEDLASIDLERIIKQHISNNMPRNPDSEKPYIQSFCDKKIKNVKSSLISIFILLLRDYFEIKFCNRSPKLSLKIENFSNEMSLEESLKVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5H4</accession>
    <name>A0A4Q9M5H4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0045p0020</name>
        <name evidence="3" type="ORF">CWI38_0021p0120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5H4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0120"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="151" mass="17427" checksum="114E98852BB18CD7" modified="2019-07-31" version="1">MKKLERYVWSVTVFIVLGISLYIIIKQLTPRIGEPDNLTMGMALTEVYNNSRKVKSIGFEFCKMLEDEKDKTYLTEMFNKMNSMMGLQAQGSSKIEKSNVANLRTHIYKIIVYLKEIESKQSKEGKVKLNDLKCAISQEIASIEKLDRFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5S0</accession>
    <name>A0A4Q9M5S0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0011p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5S0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0070"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="299" mass="35573" checksum="E03A33654E5D65E3" modified="2019-07-31" version="1">MTISLIRIEILIIIKQILDGLRFCHFKNNVYGNLSLHKFVLTDSYKVKFLGNDLHLLNKDSVKNYDCKKNEQERTDGLDKAPEIRNGSSYTCKTDIWYLGSLIYYIYTKTRYLGYIDSNSLDNETTDFISFFLKEDPSSRPNIDFLFLNNYFDEIFKFLDIFNKIQDFTWEINSFLIISKKDNLITVEKNEFKFFILEIIPDKLSSCDGLIRLFLYYYSKNVDFYRGLSKSYNFSRYIYFFVGFDLDSLYSVTQLDFTAIKILEHIVNIILSHLYAGEIFMLKDFDLTYIKMFLNYYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5Y8</accession>
    <name>A0A4Q9M5Y8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA repair protein Rad16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0005p0120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5Y8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M5Y8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0120"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="97"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="494"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="663" mass="77240" checksum="78FDEED6C9BD4013" modified="2019-07-31" version="1">MIKKNKEKSDIRYDITISKNDTIKTPNFRDLTPLEYKKLKRIDDDQKKIYSVHKNLPDQEKNFTEKLFFKEEIYNQPEGVITELLSYQKYGVSWMKSRENSIIEGGILADEMGMGKTLQILALIALDDLNEKTLVVTPAVALNQWISEIERHAPNIFEIYVYHGKNRKIINNSENKSKIQIYLTTYGTVENGYRKNTSELFKMEFHRLVLDEAHSIKDSKSSTNTAVSHIRAKKRWGLTGTPVQNRVSDLYSLVKFLKLDPHSYYFCKKCPCKTLFWLNYNIKDETRRRGFCTCGHFSSLHFSWWNRNIAGPIKDYGYTTQGKEIFNKLTRITSHIILRRTKDNLEEELGLPSKVVRVIRNYFSEDELEFYTSLYSQNKSKLMTYVMKGEVSHNYANIFELLQKMRMAVNHPFLVLKNKMNSNIPICGFCNEEADDPIISKCKHIFCREEARIFLQDSSKCPVCKINITIDLNQEIDFTCKTDINTERWVSSTKIECLIEELFFQKNDPSVIKSIVFSQFVNFLELLRWRLERAGFRCVKIYGSMPISQRKAAIEAFNTNKDITIFLISLKAGGIALNLTEATRVYLMDLWWNPAVEEQAMDRIHRIGQNKPIIINRIIIENSIESKILLLQNKKKALSASAIDNDITALNRLSEEDLMFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWA7</accession>
    <name>A0A4V2JWA7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2420p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002420">
        <property type="protein sequence ID" value="TBU07302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWA7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2420p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="67" mass="7153" checksum="745D1472DFF9A5A5" modified="2019-07-31" version="1">MKRVLFVVYKVVYKFIICYFCGTVTVIRAHKGGGSVLEGVINLGSGVRGLLEGVSNSSSIMLEGVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWQ4</accession>
    <name>A0A4V2JWQ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2218p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002218">
        <property type="protein sequence ID" value="TBU08812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2218p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="17783" checksum="CD4AB31579DA06E9" modified="2019-07-31" version="1" fragment="single">LLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX93</accession>
    <name>A0A4V2JX93_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1485p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001485">
        <property type="protein sequence ID" value="TBU10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX93"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1485p0020"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="120"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="467"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="682" mass="78853" checksum="8F8727A3BF7A3AD3" modified="2019-07-31" version="1">MFDITHHLNTKCPFTHKYVTKLLSFPFKDREHATQSLKQYITDSSLSLVLDRLRYTPFNYAVIPLDKPFTFSSKEENLKNLEKQKKEIKKENLNIFKSREDDISDSDSFFENYFINTSSIKIDTFDLWSFGHCILKDTSLTLLPNTRYGLVGRNGVGKSTFLFALKNRQISFKKMKVHLVKQEHYGGNLTVLETVLNTRISQNLSLCSNYKEIEKNLEILAAENKFENKKIQIEYLIKLFQGFEFPPEFIFSKTNTLSGGWISKTHLVRGLYAKPDILLLDEPTNMLDLFSLLFLQMVLVTLECTVIVVSHDMNFLECCDSIIHMESNSLNFYKGNFSCFVEQKNLKNEENIRNYNKQVKDREHLQAFVDRFRYNAKRASQAQSRLKILNKMEILQVPVSVSKMKYKFLSEIETDGFKEMMRLKGVSVGYANRENRENNKDFKNNENENKDFKNSEIRDNKDKDNEDKNQGTNRENQIKTVLTDLDISINNKSRVVIVGSNGCGKSTLLKVICNKNEDVLRVWGGNVTYGSGTKVCLFSQCHVDNLPYDVPVLNFFMNMGYTQDTVRSELCNFGLVCENQLIGSLSGGQKSKVVFCLLSLSKPDLLVLDEPTNHLDMESIEALSLALQDYKGGIVCVSHDIWFVEKVFKEVWIVENSKLRVYEGDIKQYKDSVIRNIKNKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL7</accession>
    <name>A0A4V2JXL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0808p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000808">
        <property type="protein sequence ID" value="TBU12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0808p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="269" mass="32389" checksum="5626619DCE2F708C" modified="2019-07-31" version="1">MNVILLFLNNFSHQINHKEKNIENIIDYCENEIKNQFLTRSTEMDSLLEREFLFLGLYKNLFNIYYYEITNFIMVNLPILLNFYIFIIYTNQGTKCVKVSHKILSISYQTIIIKTKQNKYSIEIENLFSFYVVNDKYSKKYILKKFLTYFLRKLFLIQQSIDYMLSITITGRCFIVFTDIPSKNFRKTNVMFISLFLHSLDIDNNYLHILIINKHQINIHYDDTNPQRGIIEFSFSNELYVMITNFSFYRSKIDENFLKNNFTDIISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXU2</accession>
    <name>A0A4V2JXU2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0518p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000518">
        <property type="protein sequence ID" value="TBU13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0518p0030"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="93349" checksum="6D432BB6DC5AEE0D" modified="2019-07-31" version="1">MKLYTDRANKNIFSSNKTFILVSIYIILSLKIVSSHKFTYGFIRDQNSGILFFRENKKEILLEAELCDDYELNFYYNIDTIQFNQENCFFRYKKDNFVGFEKLNNILLTNTFQNRPTKGIIECNFDLSYILKLTNDITEIPFNLNCFQFKCILTTLKYLNVVNNKNMVKLLEAVLFNNFINQSNNDLKGKNGNFEEIFSSNFFVNMELTLKKNFLLAFLNVFTIKYIFNGENLILLSKNTEDYNSALFDENIPYKSLMLNNLNIFYIFENILKDSYVLNIFTILLNQINMNSLILDNNLNLKILDLDFKFHIFLAKTFKSITISNFRNSSSILFFSKLSVIFRNDIEYLCLANLQVSSRALVLFLNQKNLKGLSLLHGVFELEHIKFIKENTDPNETLEYIKFQCVILENTWWNYILRKTNIRKIIIFFFTFLEQKDFMAKFIELDTPKFLLHLEINFCYSEIPEDFYHALIYFRSLQTLKLRSYKNDKNTEAFLAKAIENLKDLECFKIVQENIFNFLYYPIFYGHSLKYLHLESLFSDPEIPLLCFGNSYKSLSQLILVNIYISMSSLIEISKLENLTLLSIIFCIFEKNTIDLQKYNFMSKNIYSLELNDINIDIFNYFDIMNEMDYLIYLNLTTCRLFSGYLAKLSSGCNSRLKRLVYESSKLDSNDLARIGNLEVLENLNFAECKFINTNFHVLGNDCKFLNSLRNLNLSFVETTLEDLNYLKKFKNLEELSLTSFPCLNFETIKKYIFPLPISYLSTRINSKRDDFNIICRYFYEKNIIISFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK1</accession>
    <name>A0A4V6MVK1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1959p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001959">
        <property type="protein sequence ID" value="TBU10182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1959p0010"/>
    <dbReference type="OrthoDB" id="2196200at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="253" mass="30605" checksum="F6C2171A63DC05DB" modified="2019-07-31" version="1" fragment="single">DILHISARFLNTDLLISVTTKKYLFFIFKEFLIRKSNIKKAFKTDLKLLKYFYFGSKTLESSCLCGFLIFFIFYLDIEILQILDIFKCKYENIIYELINLSNINEEYFLQIIKIILKFSYKYENLITCIYRRCDKKENLLNLISFEYFKNIKSPESLRNIIVFFPDLLEKYIELCIFNEKEFLIPEIIDYLDKNGDIKGKNCIEKVFLKYNCLYLLKMCKQEIIEDLKEMNVILKIEEFNIQIQKYNNKKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK3</accession>
    <name>A0A4V6MVK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1803p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001803">
        <property type="protein sequence ID" value="TBU10382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1803p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="10105" checksum="C31CE22CE77470C6" modified="2019-07-31" version="1">MARNVAMQALNEKLMKDQIKVLNLWADYFEGYLNEKTKKGKRPQLFEIGSYIFPEKRERNGTSGRNFSSNLLCLEDEGCQSIEIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KQL9</accession>
    <name>A0A4Q9KQL9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative subunit 2 of mRNA decapping complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_2600p0020</name>
        <name evidence="11" type="ORF">CWI38_0040p0020</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002600">
        <property type="protein sequence ID" value="TBT96967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000040">
        <property type="protein sequence ID" value="TBU20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KQL9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KQL9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2600p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0040p0020"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT96967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="236" mass="28459" checksum="C366DDD96714D8D9" modified="2019-07-31" version="1">MKFKDALEDLSIRFLYFISEEDLKYTERLFFKIEEAFWHFIDFYSHKTPKLSEKVFAIRIIIYNNLPISNIPEKYKEYIKYKRNIPVFGALILNKDLTHILLVKGMQEGSKYSFPKGKRCFNETPQQCAIREVYEEIGYDISTKITQYTCEIKNDTYKLFVIINVHNSTKFTTKTRNEISDIKWFPINEIQFYDYKEEISFVKTLIPKIKEIVNKIKENHFRFNLSKFHEIFNSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZX3</accession>
    <name>A0A4Q9KZX3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0953p0010</name>
        <name evidence="7" type="ORF">CWI38_1738p0020</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000953">
        <property type="protein sequence ID" value="TBU00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001738">
        <property type="protein sequence ID" value="TBU10473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZX3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KZX3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0953p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1738p0020"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="175" mass="20294" checksum="401D86BC27C08570" modified="2019-07-31" version="1">MASKKLNDTALRRLMAEEKNLKNDFHTLGFIAMPRKQEDIKDYSHWDIYIQGQKDTLYEGCLLHALIEFHPEYPIQPPKMKFISKMFHPNIYSDGKVCISILHMADDDPTSYMKADEKWTPVHGIRTIVHSVVSLLNEPNTSSPANVDASKMFNNNIEEYKRIVRNLAKQESIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L430</accession>
    <name>A0A4Q9L430_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0522p0020</name>
        <name evidence="8" type="ORF">CWI38_0021p0160</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="PITJ01000522">
        <property type="protein sequence ID" value="TBU02248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L430"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0522p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0160"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU02248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="239" mass="27447" checksum="3BA2361DC650C903" modified="2019-07-31" version="1">MDFIGLTSGGKDSIYSIYKLIKNGNNLIALLYMESNEIYTDSYMYQTVGSEALRYIAECMDIPLHIYSIKNTAKNIELEYEGTIEDEIEDLYFAILDMKKKYVFTGVSSGAILSKYQKNRVENICQRLDLISLSPLWNLDQKNLLNEMIENGMKAVIVKVATPALKKECINMEISGIQNVLSENQCGEGGEYETIVIDCPIFKKKIIIKDYSVEVHPEEIEKRQITFYMKINKIELKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8A7</accession>
    <name>A0A4Q9L8A7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI37_0345p0020</name>
        <name evidence="13" type="ORF">CWI38_1208p0010</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FI-OER-3-3</strain>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000345">
        <property type="protein sequence ID" value="TBU03161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001208">
        <property type="protein sequence ID" value="TBU11432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8A7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L8A7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0345p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1208p0010"/>
    <dbReference type="OrthoDB" id="2193092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="11">
        <location>
            <begin position="324"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU03161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU11432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="444" mass="51730" checksum="EBD10566F98AC2DD" modified="2019-07-31" version="1">MDVFSIEDLYLLTPTGDMQITLKLAQAGMAMKSSSDSKVTTIKKEEMREIELFRGTRKFNLRINTTASLFNINNIPEEHIEKIQDLSNRWYNKVVYIKELEIANVSSGKMLVTDDFLEFSNQKLIFDIPLSEIQSVHEIKNEISISFKESKDNITEIRFLTNQKNLISNIKERTENEKFKEIVTFETLQTVLPRGKCDYIFYDNHFKIVGSTYEHKVFYSSVKGIFYLEKYDFDQNDNKEYFLALNVDPSIRQGQTRYSFIVINFYEVEEEEFTLNLTEEDKIKHKDLQAEYTGPVGSSFLKIMKILTNSKVFTTKDFVTKEGNRSLKCASKAYEGYLYPLSKSLLFLPKAIYMPHGDISLVEFSRVNLSVLTAKTFDMKIFTSEGQFTFNSIQKEDFGPIERYFSEHNINVRSEVIDDQDEYSEEEDEEDTTDIMNTSDGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L8I8</accession>
    <name>A0A4Q9L8I8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0281p0020</name>
        <name evidence="4" type="ORF">CWI38_0202p0030</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000281">
        <property type="protein sequence ID" value="TBU03525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000202">
        <property type="protein sequence ID" value="TBU19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L8I8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0281p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0202p0030"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="140" mass="16445" checksum="50030F017B0110E6" modified="2019-07-31" version="1">MNENYVVKLKLKQDQIKNFCLKQKEMPVRKSRPLETSNVLIQQNAAFKEYIPLKVRKFRMEEVTIDTIGGAPLVVKMWVSDEKSKVVNKKKPKEPVMLECDICKRSFDERRKLLIHKKCHTRQNKLVEPSSEIKTDTDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAL7</accession>
    <name>A0A4Q9LAL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0080p0010</name>
        <name evidence="2" type="ORF">CWI38_0001p0130</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000080">
        <property type="protein sequence ID" value="TBU04847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0080p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0130"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="106" mass="12699" checksum="EC6A0B3C1869149F" modified="2019-07-31" version="1">MRSKTKAYRSITQEEACVEDNEKYIIDFALSMHYLPVPTEKVEELDVKEKQICKKHNIKYGKFIEMKKAYAKEGRSCLKHFFKRGMKDRSKITAIDDYFRRHEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBP4</accession>
    <name>A0A4Q9LBP4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0133p0020</name>
        <name evidence="4" type="ORF">CWI38_0014p0110</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000133">
        <property type="protein sequence ID" value="TBU04451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBP4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LBP4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0133p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0110"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU04451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="355" mass="41872" checksum="5B8995AADCADB884" modified="2019-07-31" version="1">MVERKKSRMVNISLGTVLLDDNVGFSCVPDQIRRKSIENGFYINMLVLGRRGLGAKTLVNSIFASPLLERSRTDEINVIKNQIFENEICLDTCIATYHGNDTNLITNYIYNLNKEYYEQELGLLRPIKDTRIHVCLYLIPSDKLSENEISMMKEISKKCNLIPVITKADAFTPEELVEFKEYVNTILEENEITIFKPQIYEDDDEEFIEETKEINIRYPLATVASENIFEKDGDLIRARKYAWGLIDIENEKNNDFMKLRKLLIHFHLDELINQTDIGFYAEFRTDCAKDESNIDSIKKKRLAKIRNEMDKILRERNQRKIEKIKYEEEEMEKYYKKKIERLENDIKMSKKSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF05</accession>
    <name>A0A4Q9LF05_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2565p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002565">
        <property type="protein sequence ID" value="TBU06494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF05"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2565p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="98" mass="10824" checksum="83F3B77FF7264994" modified="2019-07-31" version="1">MVLESMRVLEGVSIGVCIKGIRVLEVWYGVKEYKGVSIGVCIKCSMVLEIKGVIIIRNKRVLVIQNKRVLEVWVLEGVSIGYKGVSNTVGVSNTVVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFB5</accession>
    <name>A0A4Q9LFB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2703p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002703">
        <property type="protein sequence ID" value="TBU05801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2703p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25600" checksum="FEE6C10B737B8881" modified="2019-07-31" version="1" fragment="single">MNTNDRSISHLNRILSLTKCKNCFKYKITKMKIQCRHLLCSECDTLSCKICSKHSIGIDIHVYTFLHDLLSRNCNELNEFKIYRKKEDIWVESQEVFEENICVKNNLYKYKYESEKEGKQEFSDLKGEILNLKNMFFGEEKNAVENKKNNENETISTLAESSFAIPFTSPVSTQKSNSETKFTQSVSSDIPKEKEIKNKENLCVTGFDKNMNLRDKERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGB2</accession>
    <name>A0A4Q9LGB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2448p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002448">
        <property type="protein sequence ID" value="TBU07129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGB2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LGB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2448p0010"/>
    <dbReference type="OrthoDB" id="6144063at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8239" checksum="425DA4077AC50A39" modified="2019-07-31" version="1">MFLCPKIFSNSNLKPSKLLEHFRSLHGGKGTHSTDNMKSKKARIDSGDTIPKLCELDIRKPLIVAFYQVAYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHH9</accession>
    <name>A0A4Q9LHH9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2401p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002401">
        <property type="protein sequence ID" value="TBU07427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHH9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2401p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="262" mass="30973" checksum="00800FCF7B41F964" modified="2019-07-31" version="1" fragment="single">TKSENEIAEVYQNIENNICKLIVNHVSYNAVLFNKNVEIIDENREDSKINLDKFNQNSKLHIPSFVIRQLFLNDSILASGYHIKVKYLNGTFDSVPTISLEDSNNKEYKYILIKMTNYFDLKIKIENLPWEFNNNDEFVNEFKNKEFNLIFMFKTNNIIELSDFIVEIILYGMTWNGIVTKYNKTYLKRLQIPMNKPSFSLRKEISEVESTVEEPKIPIKIETDFYENHFVAREFEEKSLKGNIGFNKKFYGLNPCTFFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHT9</accession>
    <name>A0A4Q9LHT9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2362p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002362">
        <property type="protein sequence ID" value="TBU07709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHT9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHT9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2362p0010"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU07709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="707" mass="79757" checksum="2A5E4CBCE33185C7" modified="2019-07-31" version="1" fragment="single">EKKKEEDWKEESIKEEENIEILEEKRNIKYCFLNPINKLSDYELEEQIKEVVRGKSIDKTYLEILSRGIGIHHNGMNKKYRELVEILFRTKHLNVVFSTDTLSLGINMPCRSVIFAGDSLYLDSLNYRQMAGRAGRRGFDTLGHVIFLGVSKRKIQNLMVSKVPDLKGSYSFINSSLLCFNKEYLISLFKYPLFDMVGVVGGDSNLLESEVGVGLESGLESGLDKGKENDKGKENGLDKGKENGLDKGKENGLDKGKENRLENKNILDNTNNTNNTIINNNNNMSVREVLIRRMYYNLLKYKFIEGKGLENMINEVIKGVLDNSKDKGILEGDNKGILEGVNKGILEGDNKGSSNYKGVNISTNKQQGVNKSTDTTDKHPLTNTTNKHPLNTTSNKHPLSNTTNKHPLTNTTNKQHPLNHTTHNNIYLTSLSDLVISNISCDTSIFLIIYIINSNAFNPLIDLEPIPFISLLCNFIQVKPLPFKTSFTLPNLNNKIFKMCKNINKKYLKESRFLYSKEVLFLERHGSGCGGDSGSDSGVGDSGSDSDVGGSSDSNISNTSNIGNTSSNTNTTYTTYTNNNYTNNYTTYTNNPNNNNNNYSKTLSLKKYSSFFYVNYLESYKNSYILDFFLHGRINDLESVNCVKVKELFCSLNIFYNFLDSLLKVMEVYGVSESVRKRVYNVYVMFGNRVWSGFNYSTKGVINSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHV2</accession>
    <name>A0A4Q9LHV2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2361p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002361">
        <property type="protein sequence ID" value="TBU07718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHV2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHV2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2361p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="625" mass="72217" checksum="0F4BE93C57925DC4" modified="2019-07-31" version="1" fragment="single">MLTIHINTNETYTLDPSDLPTKKNFKNFLTFLTTSNVPIPDLLNIAHHYNSQSHHIECRKVLLTCADICTFSVKYEPYVLLLLISHILTYYNEENIFNDKIFNSKDETKDKDESSKHKDEDRDMTKDKLNTNNLYTNTSISNTSISNTSNTNTYTNTNTNTYANNDTLLNKHFKRLETLSLTPPHTSLLSLLKAFYCLHKNKTDTSLFLFNNTSTPLTRTGIEISYFLTNTPFNYTHPLLKVLYFYNKNDSSFCIKDLEILINQYPLVSNYIYRIKGCNNNSNRDICIDNSRDTSRDICKDTIRDKSNIDNTSRDICKDTISDKSNIDNKLIDSKLIDNSNPFTDDTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNTNINLDILLTDCYSLITTNPYKAINILKPLLNLNISEIFYLTGKFYHLNKEIQNALKYYNLSVNIDNYIPAKYNICRIKGEVFSNNTLVYNRGSSNNNSLISSSNSSNILVSNRGSNNYNNYTNNYNNTTNNYNNYTNNHNNYTTPFIPSPQLYMYMAYTSLKNKNTNLDLKNLNLEFYNVCSVIIDEIKGRESVFIKYEKIRNNKYVKSYVVENNIVYHKYKDIVYENMDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLT5</accession>
    <name>A0A4Q9LLT5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoinositide polyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2273p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002273">
        <property type="protein sequence ID" value="TBU08351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLT5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLT5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2273p0010"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="122"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="439" mass="51959" checksum="6C33768A7DE9C4C6" modified="2019-07-31" version="1" fragment="single">MDGKIEISQQTKRISYKTSNGYVFIQGKQDTETSNKNCFETDYSDTLIDDFCCAIGILEIKKNEETNWYFSYVSRCNFVGKFNEINIYKINKIKFYALKKLGRKEKNENFSDEDLSNENLRMAGFVQTHNFYFMKNSDLEKNTFVSDFLENEKFIWNSIMKKRFLKISEENLEIQLFFEGSNTKSGDYNDLGIGIMVCGFFNIKYVPLKEYKKEKELNFNSKEIQINSKDSLKTLNLFEENILIQENETFKEVRHIYSDKFEIQLLSLISSAKVGPRLYCRGLDDNGNVSFFVKTLCRIYLKENIIFEITLIRGSIPLFWYQEKNPLKFEFKFSRESEISKNAFKRHFDHLKTKYGKIHVWNLLGKKRGETKLSGMYEECLLNQNIPFTSFDINNYTGNFRLLKKIFMEKLVRIEDKNVIFRVSCVDCLDRTNLAQYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMX7</accession>
    <name>A0A4Q9LMX7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_2218p0010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="PITK01002218">
        <property type="protein sequence ID" value="TBU08811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMX7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LMX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2218p0010"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="13">
        <location>
            <begin position="92"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="13">
        <location>
            <begin position="251"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="13">
        <location>
            <begin position="512"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="14">
        <location>
            <begin position="701"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU08811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="884" mass="103295" checksum="D9D30CF4F0A16F51" modified="2019-07-31" version="1">MIFDLYVIIKKEYNLRSYTLNSVSEYFLGNTKEDLPYNCMYSLQMGDKETRRRIALYCLKDCLLPLNIFDKLNILINCIEMCRVVGVPIEYLNRGQAIRVFAMICRKAKFMGYVVPVVENTEGEKYEGGYVMDPVKGFYEDCVAVMDFSSLYPSIMISKNLCYSTLVRKKDFKEICGNKNREFEKESVSYEDSIGESELEGMDEEYDKGLDEGVSDKDIDVGVNDRSNDNYHPLNTSTDKQQGVNNNKDKQHPFNNTPNNYHPFNTNDLCLTPTNNLFVKKDILEGLLPIILKELLEERKKAKKSLEIEKNEQTKASLNARQLALKICANSVYGFTGASKGFLPCMEISQSVTSFGREMINFTRKLIEEKYDVKVIYGDTDSVMVRFKKISVSQIFQTSRDICEYVTQRFDKPVRLEFEKVYCPFLLINKKRYVGLICKRGSEMEEKGKESNDSKDNIECRESNSKDNSKDTKKINLDKDNKDNDIRDNLDKEKELNKDNNNDIRDTNNNTLIPYKIDSKGIETVRRDNCKLVRNVMESCLYKILWEKDLEGTKEFIKKVITDLYMNKVDISQLVISKSLTKSKENYLSKAAHVELAEKMKKRGEVYGLGDRIPYVIIKGSKGMAAYERAEDPVFVLENNIPLDVEYYIENQLSKPIHRLFEPIMDNVSVLLKGEHTRSRMGVSSKFKGSMNVFLINQIKCLGCKSKGKILCDLCSKEYSKYYLGCLKKVEESKKVYCKCWVECQRCIGSVMGEVICANRDCDIFYLRSMAKKELIEETEKLEILKRFEYLSCKSKEYYFIKRCLIRDEFYKKECEIRYLSCKSKEYYFIKRCLIRDEFYKKECEIRYLSCKSKEYYFIKRCLIRDEFYKKECEIRDLSCKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP31</accession>
    <name>A0A4Q9LP31_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1978p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001978">
        <property type="protein sequence ID" value="TBU10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP31"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP31"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1978p0010"/>
    <dbReference type="OrthoDB" id="2189670at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="191" mass="22846" checksum="69AFAA47D82FE68B" modified="2019-07-31" version="1" fragment="single">VYYLDKKKSTSELYFLLEKSKTQDDFHLILTTISCMALENLDKRIKSRLNHNIIFLPVLPYKSVKQYVNEKAHKIDPRFSALLKNNLMQKYKINFDFESLFNILNSIHISLLIMILNCNIKNHKMIEQYRKFVFKHPELRNIKDKDISDALGDLLDLGFVDKKYNYVFSVDELKNYISKNRPFYLKRLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPI7</accession>
    <name>A0A4Q9LPI7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1803p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001803">
        <property type="protein sequence ID" value="TBU10383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPI7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1803p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="271" mass="32029" checksum="F1CF38D6F004DF00" modified="2019-07-31" version="1">MELESIFIDCILNLPGIEILYLYDCNIGNYDEFHIYPKNYSITTFSFLGKKMINVNLFYKFMCSMIKLTNLEICNDSLSLLLDKDQNSLFSHIIHLNILDFCCVFKIYTNNNSFYFPFFISEEISVGVGFPAGTLKKIFSIQENLNIKKLLYSENYLDGSDSGALEYLNFLDSIELSSNIVEIRFHELFDISKTYKLKTIELKEIELYFQDIMFIRSLNNLEILNLINCGFEKDCYRNIKGNDFKNVKFFYFEYFSLNKNKKIIKHLKEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ12</accession>
    <name>A0A4Q9LQ12_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="8" type="ORF">CWI38_1687p0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="PITK01001687">
        <property type="protein sequence ID" value="TBU10549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ12"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1687p0040"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="19444" checksum="1FA45455AEFFEECD" modified="2019-07-31" version="1">MKKIIYEFDQCDKKRCSAQKLLRSSKVILGRRNTYFKGILLSPNSKKVISIEDKDVMEKYGLGVIDCSWSQMESINVKGNSRILPFLVAVNPVNYGKPFKLNCVEAMAGALYICGFESEAFEIFEGFNYGDTFFKINEEILERYSKCKNGEEIIEEQTKYLNENRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ19</accession>
    <name>A0A4Q9LQ19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1748p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001748">
        <property type="protein sequence ID" value="TBU10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ19"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1748p0010"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020811116" evidence="4">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="346" mass="41725" checksum="69C6E63475DCB222" modified="2019-07-31" version="1">MFLLLFTFYFVIYLGKENAVIIVLSKNDELEKILKCLNTFERMFNSKYRYPYVFFNDSEFSEEYKNKIRDVISSTVEFGLLSSEEWGVPGFIDNGKMFRKIREMKKKNIKYGGLLSYRKMCRFYSGFFYRNELVAKYDYYWRIEPDIEFFCEIKYDPFLFVKNTNKKYGFVISVIEIMETVPTLWNAVSDFIEVYDKKYPNYKMKERMKNIKNKDKDGDNYKDDYGNLRFVTDGHGFNGCHFWSNFEIAAFDFFRSKIYSDFFNFLDRKGGFFYERWGDAPIHSIAVSLFLKKNEIHFFGDIGYYHPPVTYCPSFKQNSLCKCDREKSFNYKRKTCLDKLEIKQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ47</accession>
    <name>A0A4Q9LQ47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1682p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001682">
        <property type="protein sequence ID" value="TBU10558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1682p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="313" mass="36944" checksum="2E3DF5B202FBF80A" modified="2019-07-31" version="1" fragment="single">MKNTEEDFINGSQLNVTEEMKLLEFTVDDCYFSSDESTSTSKYAIDCNESYNYLKKNNKEEKPLSISRQNSLNEKMTNMLNIGQKKDIKNRKIEKENKNMKNNYKEFTDKNLLKVKLPLELAHCVLCKYNKNFGKLLSGRFLMVYKKTNLKSINRRYRETHLILKSSTSFTQKMIGFVNLKVLDVMDINYFNFEFIEDLNLQKLKIKNVKNISIRKNISRYKIKNVKIEEMYINLIELEKIIQINSLIGITIKNVNINGSNNINESLLQSIILKTQLKKLKIIQMKISEEFICKIVNNLHLNVFKFEECNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ76</accession>
    <name>A0A4Q9LQ76_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1617p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001617">
        <property type="protein sequence ID" value="TBU10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1617p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58163" checksum="8F5D806544AAD79F" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVMKSDSELQKCKLHPPAISLPSSSYTTITPPPPSKTCSKMQNSGLDTLPSPNAPVPSSVEVSACDPSYDMTNPCTLAIPEGNRLMALRTIFDSVTADPKMPRNGWTELHRYYNEKFGCTETLEEVKSEENGERRRLATLTDKCSKPDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGAHVPESITEAAYIMQAAQVCYDEASRKQKPRSAWKENIESKISTLVLSKDLLEKARKQEKLSTLETKSFNSDTDLSEALVKKNESLNVHEKKITIHESRKQFRKENRMFELFRGRFYRGLSERMESEHVVSRDEIVSFWSTMWNKNDDAVTYDDYLIPFVSDNHPTMFPSLDEFVNIINWLFNWKAAGIDGIYNFFIKKLTTLHKYLYDIVKVICLEGTTQADWFYCGLTYLIPKGIPRRSSDYRPITCMSTLNKLTTKCVTKVVQLEVERRGLLAENQLGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG9</accession>
    <name>A0A4Q9LQG9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1582p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001582">
        <property type="protein sequence ID" value="TBU10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQG9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1582p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26695" checksum="8E37516B835D7E7E" modified="2019-07-31" version="1" fragment="single">MKFEIISVTNPLESLEFEQTSSLFFTEDPLFYKSFFYGNKKGVIPENILFRGRFYRGLSERVESEHVVYRDEISEFWSTMWNKNDKVVTYDEYLIPFVSDTHQTTFPLLEEFIDIINWLPNWKAAGIDGIYNFYIKKLTSLHKYLYDIVKAICLEGTPQADWYYCGLTYLIPKGTPKTGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLSENQLGAVRGVQGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQQ4</accession>
    <name>A0A4Q9LQQ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1793p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001793">
        <property type="protein sequence ID" value="TBU10396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQQ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1793p0010"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="84500" checksum="62D041C46754419A" modified="2019-07-31" version="1" fragment="single">SNEQQGVSNNTNTLHPVSNSTNTLHPVNNKSNEQQGVSNNTNTLHPVNNKSNEQQGVSNNTNTLHPVSNSTNTLHPVNNKSNEQQGVSNNTNTLHPVSNSTNTLHPVNNILIYSSLINNTYLPYLLFVLEYLWIVNNECEITDCNEEYVKGIDRSKGGVNEEGSEDSVSEEDEEGVSDEGSEGGVNDSTNSIDEEEGVGDEGSEEGVSNSTNSIGEEEGVSDKGSEEGVSNSTNSIHGEEGVSDKGDGKGEEEGVNDKGDAKGEEEGVSDSNCEEYDEEGVNDSTYDEEGVSDSTIVQEGVSNTSNDEGVNEEGVSTIIQEGVGDCSLIDYEVGVNESNNEQTALTGDNYSTIVEEGVNNTELPLTGDNSLELQQGVNEQLDIEEEPLTGDNCNIEGGVNQQTETTDTLDLLSNTMHNNTPLNNSNDSPRENTPLSNGKDSPRNNPPLNNSEDSPRNNTPLTNGKDSLVDNTPLNNCKDSPRDNTPLSNNTDNTPLNNNTINNTNITPLFTTLDTDTLISRLLLTLNDTGGMRYNNGCYRSGRKLSIKKVVEYIASGYKRDRIFMRRNKKGGGICKICIFIDNSKSMKDYKEVVFNLLNILINIINNIGCNIEMYRFGNEVISITGKSDMTFTDTVSDICIGDMGDIIDDSVVLVITDGIFRCDEIYENVLCLLIDRVGLRDMDRVSVVGDEVKVVKFLDEFKMKYCVVGEDNFVEGDSKSNEREMGVVDGMVMIGVGMVLRYILDINFTYYFKGFIMVYYKGFLMVLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQV1</accession>
    <name>A0A4Q9LQV1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_1652p0020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001652">
        <property type="protein sequence ID" value="TBU10607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQV1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQV1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1652p0020"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="499"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="641"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="859"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1201" mass="141096" checksum="3CB1553A42E512DA" modified="2019-07-31" version="1">MKNSRLVLSGIKLENFKSYKGIHFIDNIDPHFTAIVGPNGSGKSNIIDCMLFVLGFRAKKMRHSNLTDLIYNDGSKCNSCSVELFFKKGNTSFSIKRELFVNKKSNYYFNNQEVNQKHIYEFMTKEGVDLNNNRFLILQGEIENISMMKPNGLLEYIEDIINDSCYVEKINKLENEISVGKEEFESKKTLYNFCEKEFFFINEKKMENDKIISLIVEMLKKKNENCFFMKEKLERNLQKNENERLEIKSKLNEINSKNYENKKILDQKEILLQNCRKELKKEENEYLSLKKEFNKIEKENIFYEEKKERLSKIICNLKSEINDFEIKNKLNDSENKIIKRELLENENEIKEFKESVDSLKNEIQKSEKNNYKKIKPLVCKMKELENYIFEMSKEKSILLEKKGYLENEINFFKDKRKINETEYRALLDERDTLMDLINNNDLIERELTGKESEILEVESDLKETYHELNKRIMKFEEIKIHEEKNKKQNRVFEKIKSVKGVIGRLGDCGSIDLKYEIAINAAGGGILNNIVVDTTSTAEKCIGIIKKNNLPRTTFIILDRIENIPELPQESVPYLVNLVKCEEKLKKCFYFALKNTLVCNNLEEANKISFGVQRKRTVTLDGKLIDKTGLMSKKGNLRGNFNVSSEKIQKYESEIKQLKEAVKSMENTKNELSNEFKLINSNKQKIETSSKRISEIEIKISKFQKEELEKSHTSEKNMTNQIKDISNNLEIIENKISEFKNQINEYNSNISDIQGIEVKLKKSQIEMLFDKIELLEKRNQELLLKENVDLTNIINEKRVFLFDKEKEFSNLQPVLNYEEFRIKIENKELTYKEKLNDCKIINDEYIKIKDKIGNDFHIEAELRNKSEDIFDEIKKTRKEIKVLENEKEKNIQEFKHYSKWIVEVESLRCEGNLGYEGKSLECEGENLRCEGDKYIKEENVKEENVKEENENISNTNSSVTKNSKNTIEIFNFDLKNISEIELSDLIKETSKKIKNIENKITTRNLDIKLLEEFEVKQAEFEKIKSEFTYFKEKMENIKNELNEIKNLRTEEFMNGLNEITKNLKEIYRIITFGGNAELELVDYLNPFTEGIILSIMPPKKSWKNIVNLSGGEKTLASLALIFALHCYKPSPFYIMDEIDAALDYRNVSVIANFIVEKTKNTQFLVISLRNDMFELANVFLGVYKNNNCSKSIVVNFKSLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR34</accession>
    <name>A0A4Q9LR34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2039p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002039">
        <property type="protein sequence ID" value="TBU10081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2039p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="587" mass="68453" checksum="D99B1AA6C2987A50" modified="2019-07-31" version="1" fragment="single">TNTNNNKPYNKDNYFEFRGYEILVCNSEGVIVYRRGIYKIIYLIIVYMLNLMKYEKYFIGKNFFNSLFTVFGNIKMCCDVEDDVFWEDVFEGVKEWMEGIKERVGSDDESGNSMFEWKVRKPMFMSRNNKRVKVSTDEMFEEVVDKRDMSVRVFKRGCFTDSTVVYKPKYGNTAYILEVAHSENVDVVVDPETSVLSVNVSNKKFDVKPRVQLRAIRSNRIREINFEEGSDSEYNEESEGSDFRPVIPDFTKGGDKPEKEEEAGEAGVKRNFFLELNSDIREFPRNKILKANFGDADYYIHYTTQDADMSVDKEILEELKEKIELDCNLDIQDIKNNTCSIKRLLANKEIRENLNMESLLCELKDSEVCKEGYRNFREKCCKHYKQFNEDTVNIDGILRESRDKCQEVSRFLISGDCCQLIRMGFFVQMCSALKSTSNLSYPYEELLLKSFCKQDMGITRFFLDTVICMGKTKDAYIATLLKQWNSYITNHWYSYQLAREKYRNEKDVCEVIEQCCAASSDVMEGWDVPHTNTLDDIEETEEEKERKRNVTTRTQKKSSSGIWGKVGIAAVVITAGIIIGGFCWYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR89</accession>
    <name>A0A4Q9LR89_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CWI38_1555p0010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001555">
        <property type="protein sequence ID" value="TBU10777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR89"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LR89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1555p0010"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="845"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU10777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="981" mass="117027" checksum="6EE946BA1C8FEE1A" modified="2019-07-31" version="1">MIWFEASSPYLEKLCSFCENPFPTDKCSYCSVSLHRNCIIEHLKVNNECLIVRTCKYCNVDKRCDLELQKNIANSFFNLTNKFENSDFKNKNEILLENTNFDRKKEFPIEIKKLEIYDAAKQIFTNPLKFYSVISNLQNYKETIIEANKEKNERSEFLSSAKISNILQNFSNSIETAICKKCERFFHSYENKIKKEKNIFDICLDCRYCISCNVFSYENVLLFFLGKYIVFCQNCEIIFKKNEMCNICFKEFKTDDFDIEMMQCDFCHRWIHLDCDARISYDNYLLLSKNSYLCVECTEGLGFDYNKIFIGNISNYDSDSEYDVDCNENIESEDINFKTNEMEKTLILNDQVEENKINSENSIESCNYKDKNCDSIDFYFNIPNLNIFENNLENKKIDFPKALDFENQLFSFNEDFTEKDKSSILRKYLIYYKNDDLKCLICCRDLRRFSVHQSTRLICIKNSFPNFYVHICCVFYYWLEFRRIKISVTNKKIFGIENRLINYKEIFDKTMDLNCEKTSDCELNNNRIKRKYKKKNTQLLEEAFKKDLESENKHTNNLKIKRKRKIKSVESENIFPLEIIYKSIKSFSCVLCKENGANIKCIDCKDGYYHFDCSLNILFIGQSTVPRCRNHFFVQYFEFGKIVCFKNRKEKNETQKDKNIELGSANATEKNEISEQEIGKIKTKRGRKKKKCLIEERNESNKEKHLNMCLRYKNVIYMNDLWCKIFFLQNTKNFLFFDGFSFWINENKVFFPEISYLQTNSEEITIEDLFLLNEDGYKTFLDVKKKRNVGKRSKHECLDFEHQIIKENYLNSNFSKLIYFFSKYFLLKKFNMTLTYFLNFVELEKGYCLKKSQIQGYGLFANRVFLPDEPVIKYIGEMIDVTESNFRESFYGKDRCYMFKYDDDMIIDATMLGGLAKYINHSCDPNCYSTKVVCGDNIYIFICSKRIITVDEELSYDYFFEIDEFNVECQCGSKKCKKYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR2</accession>
    <name>A0A4Q9LRR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1955p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001955">
        <property type="protein sequence ID" value="TBU10190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1955p0020"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="377" mass="44676" checksum="736F05769BFB6408" modified="2019-07-31" version="1">MHISLIISFETVRILFLSITFSSMRTDDLFLLYKEDSCCVYSSRPENHNNYTIKVANGEENNQLLEKEVQFYTMLDHYNLPKLYHFFIDKNNCLTLYIECRDSNLKYFLEKIVEKISFDFKLTISKMLIDALYYLHSKNILHNDIKMENVWIKGNKILLSGFECLTKQDFKSVGSYKKKSESQEYVASKVIKNNKLYFAADIYSLGKLMKQIFNFKNIKYFGPGKDERVIQMDSIFDGMMDHFPENRDSLETVMGFDIFSVFYSFVFCFCKQKDINFESVNGKFIKKGNTLINIFINRKIIIICSCSEQKPMRTSIRRKMHSMVKNIKVWRKTKIFDKKNITVSINGVSKPIYFLSLDELNDVELIFLRFKKFWNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRV7</accession>
    <name>A0A4Q9LRV7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1283p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001283">
        <property type="protein sequence ID" value="TBU11283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRV7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1283p0010"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39383" checksum="67AA0481143AF0FE" modified="2019-07-31" version="1" fragment="single">CLEKSKEISNRRAAIHKVENNNKIHLALIKGFLKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRLRNEAVFCYIQDRNVFWRADGMCQHCGKSGKTVDHLATRCEKMLDHDYTRRHNEVVRCFKSSKRIRSHSVQEILDNEYPEIRVDTRIKTDVTIRNNRPDIFILDKKKNKITLIEYDLLANELDLIYKCSVEIIPYVMNWDGIVTKYYKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASEMHEEPTPPLKGEKREEDDAKNFKPKNSTPFISQGGTTLEEPTNNINEESDLEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS74</accession>
    <name>A0A4Q9LS74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1823p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001823">
        <property type="protein sequence ID" value="TBU10360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1823p0020"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="468" mass="54651" checksum="70017657A54D25E0" modified="2019-07-31" version="1" fragment="single">MATKINSEVGKFISFYREKKGVETKDLYEHQRNILLKRKLKNGEPGYGNLMILLFLAIAEGKLDYMEFISACGLKKLDIKIIGYLGANMVKDNFYNLMMVNTLRKDLASENYNDLSLTYICNLIEIGEQFKELKDLICLKSTKDITFCKKLIAISRLQDKPIVSKLIMGDSNILHVKLQILIDYISCLKEKLDCEKSVVYPFSKNSYQNLKNSENSIFLDLCENDILYLISLYPRTTNINLKIKILQLFSSFIDKFNFNELYKLNENIEASIIVTGFLKKTNLEISLSIESAIFLFSIGYQSVVANSFVFRLIESRMSLCTYYGLYFARKFRIFKEVAIERCFSIGLHKYECLETVLDLITKANYLEIYKRKEEVFLIMESNLVKSDICHEKWSKILKKILKIADQEFVFKIFLENPYINNSSPVYEQLNEKSLPLLFEKIKEQESLEYFDLIYTLLPYQQNESHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS78</accession>
    <name>A0A4Q9LS78_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1459p0040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001459">
        <property type="protein sequence ID" value="TBU10956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS78"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1459p0040"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="13706" checksum="AAEF748B88E9E0BB" modified="2019-07-31" version="1">MVKKIQETKAAKAAKATRSSSKEKKKWSASKAKETNRRAVCIDNELLAKIRKEIVNMNYVTKSIVSERYGLCLSLSKNLLEMFCGENLIAPVLFNSIVKVYGKVVKKEKIETPKVVEGEAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ6</accession>
    <name>A0A4Q9LSQ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1109p0010</name>
        <name evidence="1" type="ORF">CWI38_1112p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001112">
        <property type="protein sequence ID" value="TBU11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001109">
        <property type="protein sequence ID" value="TBU11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1109p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1112p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="150" mass="18184" checksum="43D5F80B190FE6ED" modified="2019-07-31" version="1">MIFKRKGNDSYKFYIVKTDKDRELEAITQQQNNQTNINTHQENITHLTNSFFQLSLMCKELKNTFNTTNEDFPFEKIKTLLFEIENIKKIQNDCDLPFELLEYISNSNDIKQYFINIENTLQQLYSENLCKKENFKTFKKIYKKYFKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSW4</accession>
    <name>A0A4Q9LSW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1143p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001143">
        <property type="protein sequence ID" value="TBU11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1143p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="42901" checksum="DE27AAD6B3165F19" modified="2019-07-31" version="1" fragment="single">RKNAVNPSIFENPIIFDFSIKGVFEPIDMVATIKTLAFFKVCNDKNFRLFAKSFLEFTFAKLNIYDFYSDKNEYQLENESGKRIALSFLRIFLYENNIKKIGNYELFCKSFKEYKKFKSKNFFMLADKFTRNFYFIEKHKIFFKNVFYCHKKIIHFLFLQKLVSFEKYYIDDFVLHCLYLSDMTIDFCKSTIDSIFEEFKGIKTDLENLPNKCEYKWNRHFLRSSVFVNAVAFFFYNCEIKCLNISIEDSQCFKHDVLVTLKLECVEFKIGICHFEFFIALHSLIQGKRSIKNITLNISRLQPDISIGLNQITFEKIFLPPKFEITLSIFDSPKNLSNQEYANLIKFILQPKNELVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT00</accession>
    <name>A0A4Q9LT00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinetochore protein Nuf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1223p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001223">
        <property type="protein sequence ID" value="TBU11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT00"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1223p0030"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="172" mass="20571" checksum="11A6C89384BB313E" modified="2019-07-31" version="1" fragment="single">LESRYNKLKEKINNFEDSISDLRRILKTAVQIQNFKKDKEKIIKENMILESESKNVSSYMDSLDNKYSHIIKQISHLETKINNLQENDNSYFYGITSRMEDLKINYDQISESRNETYSKIEVNNKKIKEYEQESLKLKENHENEMMSFQSALCGIKDKIYNYLNELNVYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT91</accession>
    <name>A0A4Q9LT91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1024p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001024">
        <property type="protein sequence ID" value="TBU11828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1024p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="30154" checksum="482015CE76906E35" modified="2019-07-31" version="1">MFFLKLYLENFSTIVLYSLKILWNLTIVFILGYLDLSPEILRKDERFLFTFIEFLVSVDKILASYIKQGKQAKSIDVFFRIEYIFVEKLDIKLLEFLIEKIPIENMIVHDNLISSGNTFYTSQSSECIDKIMDDLKPLLQSFKKIKTLKIHNCRNTSLFRLLPYFEALEFLSIEGTVFPYNTTFDFDLLKKFRDTLEILRLHHFGSFTNKERITFKNLISMDLDFSSLHRDQINSQLLNRINLEVDVIFDFSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTJ2</accession>
    <name>A0A4Q9LTJ2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1401p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001401">
        <property type="protein sequence ID" value="TBU11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1401p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="11126" checksum="CAD08F0FDDE88D8C" modified="2019-07-31" version="1">MYEGGQMDRKIILENALKRLLKEKKYYLKELEKLKSKESNNMDEYEIRKYNEKCSECVGCISECNINIQKFCCELKDILEKSGDNSEVLKEIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN7</accession>
    <name>A0A4Q9LTN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major sperm protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_1181p0010</name>
        <name evidence="4" type="ORF">CWI38_0958p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001181">
        <property type="protein sequence ID" value="TBT99887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000958">
        <property type="protein sequence ID" value="TBU11969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1181p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0958p0020"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT99887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="152" mass="17726" checksum="8ECE37A851E2B981" modified="2019-07-31" version="1">MSEVIIRPQDKITIKEGERVSILTIYNSSVEGKGFRIRTTRPKEYLVKPTSGIIIPLQTVEIQLFINETAVPASDHKFMVEIYDFDWRKTQDDFKEFLKDQSVKPLMSHKLSIEIGDEIKENGKQFEIVDAMSWCVIGYAFMFLIWKIISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX9</accession>
    <name>A0A4Q9LTX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1427p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001427">
        <property type="protein sequence ID" value="TBU11020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1427p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="245" mass="28742" checksum="FD2566F961B5E21C" modified="2019-07-31" version="1">MYKNVRDIDFMLRKLNIFPSLVRYLLILISIYILLAFTVTYMTHNYLLKNIEKFVQTEKGKYAMSVLSTNLLILLFKKEDKDINGTIRYPSEEATVTEECYTKIHNSLSRKGVPMYFINEMDTFENEFSNTLELKNFLKLTNSIFFKAFRLLGLSRVPKYLCVSKFLKLYNFICSNSVPKTNQEERNIVFYTGDEELKSLCFDLKFDLECAAPINQNDFSISFSEFGDSKILIKKILAYMIFSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU24</accession>
    <name>A0A4Q9LU24_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0887p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000887">
        <property type="protein sequence ID" value="TBU12129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU24"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0887p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12326" checksum="424D711BF71CEF8E" modified="2019-07-31" version="1">MIVILCISLGVHIVLFVAYFCSIFVSNICTFVIPKKQVRNIPLRQSKSLFQISSMEYDYIVKNNILLHRNEIIQIIDVNGNDVVVRKSNGEEFQVKKWFIKDGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU63</accession>
    <name>A0A4Q9LU63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1357p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001357">
        <property type="protein sequence ID" value="TBU11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1357p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="27521" checksum="538152A38C3BD4A4" modified="2019-07-31" version="1">MKMLRLHRIEYYDKAIFFLGDFLCFCFKTKIRPKQKKYLDPIVFKLIENIIKSEPTIVNMFLHRGELPDTHTKNAQLNRIKKYGLKELSIEQIANLLISLVKSYGGLFHRELAYQLHDALFIEPDYEDFGYFEYYMRFAFTETERKLFRELKSMWIHLSEWKHTVLTDLIFANLDMYFPECLYFNKHNINTQIKLINYFNDFNFNDVPIVLIKKATFMFEKIMAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU93</accession>
    <name>A0A4Q9LU93_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GLTSCR protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1363p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001363">
        <property type="protein sequence ID" value="TBU11140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU93"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU93"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1363p0030"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="47687" checksum="BA8E8F589CCB7C58" modified="2019-07-31" version="1">MEGHKNKKEIRMSHKTKYEECNLDLNSQIPSKVDNMSSKPQKEKEPFKSLSNSEKEIIKVKKDKNGEEMGFKPSNILASECNNSSESSKSNFIDLESFKKDCDNTDKEIENQTEQKQEVSQKKRRGRKPKPKLIEETSGENVVKLKRKRRTKKEMEEEKSKNLVKYEYFDNQSYESLEFNLNKKDEENLPFSEIKDQFTPSDAYNYKIFENISCLVQRREKILSFLCKEQYQLTNPDLHPFINENHAYECLLPYHIYSLPLYEDLLFFNSREDPTLLDRTVNLMDEFENILLNFYDEIDFEPDIIVDLLLIEEDRYIFNKLHTFLDKLNEEEEINEREIKYNISRSKRRKGWKSEPEDISFKIKLKLNTEEIQNYKRNEGEEKIYLKVKKDIIDKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC3</accession>
    <name>A0A4Q9LUC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1344p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001344">
        <property type="protein sequence ID" value="TBU11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1344p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="29438" checksum="F594FD7691006250" modified="2019-07-31" version="1" fragment="single">MSIQIKNLHRSKRTAAIFILLATHVLTSILTTVNFYIINEENRVNNYINSESTMDIMFKNEKIEYFDEINRITILKDNVLRQESKGGITKYYESNTVTLRYTDTNLLNSTLLKSLYISEKNIIRVFLKDVSTSNFLLFLKLIDNPDLLINQIDIKTFIDILTIITILDIKKSKQRNKIIKELLRNLVYGINIKSFNLENICCLDYTNNLVKRSILRDLLIYFLEFVYFNEKRTRLHIVIKRSCDVIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH7</accession>
    <name>A0A4Q9LUH7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0809p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000809">
        <property type="protein sequence ID" value="TBU12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0809p0020"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="350"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="951" mass="110401" checksum="2FE5ADC36B2C1E1B" modified="2019-07-31" version="1">MTILETIPPQSTIHKNTHSPSSNTFQYRCHSKGNRLMVLHSILDSVTAVEQEWPGSAMSAVQKRFERMPRNGWSSILRHYTGKFCRTVDIVNGERCRIATCLTEPCPLTDTTMVVRTRKLPILKLINRITGEYAEFHVPKNVSDAARIIQAAQKPRSAWKENIESKISKPVLSKDLLEKACKKEKLSTSKTKSLGKIRREFNLDLSKINDLSEALVKKNEALNVYEKKITMYESRRKFRKENRMFELFRGRFYRGLSGRFESEHVVYRDEISEFWSTMWNKNDKVVTYDEYLIPFVSDTQQTTFPSLEDFLDIINWLPNWKAAGIDGIYNFYIKKLTSLHKYLYDIVKAICLEGTPQADWYYCGLTYLIPKGTLRRGSDYRSIACMSNLYKLTTKCVTKVVQLEVERRGLLAENQLGAVRGVQGAKEQAPMNIALNKEYENNLKATCIDVKTAYNSLDHAYLTQCIKNLNLSNWILKFIKVTISKWKIDISVGYGKIMSKKIDRGILQGDSLSHLLFVLCMNPLSRKLNEKYTKVSIKTDAESYETNHLLFIDDLKLLAEDGQILEEYTEEVKKFMNKIVLEINKEKPATNKSFEEVQLKLIARVERLCRTRLNSRNIFQAMHQLAISLLNYHISNKIHLRPGCKERLYLPRKELGRDLHSVERAAILNVENNNKTHLSLIKNFLKIKYGLEEEKGSLKPLDGAVVCYIQHRNVFRGAKGMVQHCNRSRKTVDHLATRCKKMLGYDYTRLHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEIFDNEYAEIRTRYFILEKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHNTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLNASLSVILGAEIDKQPTPLLKQVDNEEDEPKTNTNKELELEEEKEVVEMVEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ8</accession>
    <name>A0A4Q9LUZ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0737p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000737">
        <property type="protein sequence ID" value="TBU12489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0737p0050"/>
    <dbReference type="OrthoDB" id="2194794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="86" mass="10059" checksum="1E8F083382B57EEA" modified="2019-07-31" version="1" fragment="single">GLNDDEEIASYRIKYLPPYSPFLNPIENVFSVWKNKVSRGGARTEPQLRILIYEKFNEIKGEHCSSFYRKMLGYLQKAEVGQMILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUZ9</accession>
    <name>A0A4Q9LUZ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0737p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000737">
        <property type="protein sequence ID" value="TBU12488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUZ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0737p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="441" mass="52393" checksum="B1C9DC8D8F3AE731" modified="2019-07-31" version="1">MNAKKTISIHFYGDEAVNENQSHCESSLTSNYVGENNMILPNSNIRVLNTFLIDVDNFLLKFLPEEKFGESQHQNIYIKQSRLIYSDFVYFYRIIMMFPGFIQDLNESKYHLIFKILNIFDFEKNKQLKDFLRVISVSIMFNPNILNGRSIKSKQTNKHGLSDIISKIMVIEFFKICIFPKATIDSLKNIPRGASLAQYTQPGFIKLSEEILYLDQDFICKILKLKKIAREFFDILDYIFGIHTFKSLFLYNIDYTRKLSFFFDLSLFENIDELFLYKCFQVDCLLQTNYQKMHFKNVEILNIIHCEFTSANEIKFLQTLNLQSVKFILKNEQTEFRYCHSDLCLNLQNIVFNLTKEIFDYENQKYIFEKETLIPIYESNKEFILKCYQDRSKIEMIGIPNILFQTYFTVELSNPYINFDFHILNIKVAKNIALSFKNTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV98</accession>
    <name>A0A4Q9LV98_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1162p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001162">
        <property type="protein sequence ID" value="TBU11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV98"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1162p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="440" mass="52374" checksum="6F3DDAD6998CC083" modified="2019-07-31" version="1">MIHYIIYLHIVLCSIQEIDEEIVNKPIDIDLDRICNEKEPKNFIRDINCEKPIDDTIQTSNSTCLASNDINPDLCSICEGICSNSRKYQKCLDKEECIVCNKIPRPCLKYLQSYVLSRKRSHSISKTRNESKKVLIDVIDPDKIVCKESLDAIFGKYQLISGFLNGSPELKKILKEYPNMPITFEEIKLLNPTLLNSLIEIIKFSRTKNFQFVNYEAEMVYIHFNLDEISCEDLFTDIFLKILNFNIIEIEICKFKEILNEISHFLYNTKFPLKFWPEDKSHIKIKLEELFNSYNLKYFDLGIFRIRSLIFSIYINNSYLNTIPKRDREMYMLLILLEKCENEYIRLFHKDTLLNTQDNRLKIQNIKLDFKKKINEIMFRIVSCIQYNTNYYVSFDLLKVLFEDITNIIQIEKNNELKYANRIFNDFHLILFLLPDIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVB2</accession>
    <name>A0A4Q9LVB2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0687p0010</name>
        <name evidence="2" type="ORF">CWI38_0966p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000966">
        <property type="protein sequence ID" value="TBU11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000687">
        <property type="protein sequence ID" value="TBU12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0687p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0966p0020"/>
    <dbReference type="OrthoDB" id="2194158at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21538" checksum="9FE8F7440A504654" modified="2019-07-31" version="1">MILFSIFLVSILAGEVKIPPNGRLHFEDSAKQNQLYKFEFYESSGKPVHVIIVDNRQRKIAEWNTQYAVMHTKAQNATTYDFIIRNPNKAEVSVFFRCPDVKKELHGALGPIEDVDYVAAFEELLKNDVVSYRNYSKKQKQHSEMVSKSRIWIIVLMIGEIAFSIAIIRYLHVMTTSYFNQRIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN1</accession>
    <name>A0A4Q9LVN1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1090p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001090">
        <property type="protein sequence ID" value="TBU11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1090p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23190" checksum="ECC3B4A25CBCF27C" modified="2019-07-31" version="1" fragment="single">DVKIRCNRPDIFILDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCNVEIIPYVMTWDGIVTKYHKTYVKRLQIPINVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPLPPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPTTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW08</accession>
    <name>A0A4Q9LW08_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0587p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000587">
        <property type="protein sequence ID" value="TBU12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0587p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="635" mass="75442" checksum="500DF3F618BBAC0A" modified="2019-07-31" version="1">MFVCFMYFMKCFSAAYEEVTSECIENVYEELTRERLEKDHAEVSKVYDENDYEKISELGLYTNPRDCIENLRFQIQTEKIITKNIVFSYDTSPFDLYESYSDISFRKIFQNIINFYEKNDLKTVLKRENETFNAKSKLFCILKSLKTSIFLLRKIPFVTDQYLIYNSKIFAFWYGLFYMNTKEQNKDGDFLHFSFQKQFYLENFIIIDCFLHKSDLFDIFNEFLSTNYKISLNKNLNYIEMIIEKALIENSDSTFLIAEELCKMASHNFSILFLSILTYFHWGSSTYRNSRIFLDQIARNEIIDIYKKLEIYLEDRINLINLVCLNIGWDVTCYLFNVYGLGVDTWFESYKLASQKCVIHFKLPFTKISFHVSDNIKNHLVILNSSITGLSRIHSELTKVKIRFLVYILMSLNLDPEDDELCIILKLYLTYGMVLYNLDSINLTDNLNLKNNNFINWLSYINSALNGFYHLRISVYTKFLCAKKLFTLILVMIISLEIDYKTKLNFQGLIEKLLISLKMHGFDICANLLKEDSEKLQNNRIFNDKFFPFYYNALVVCKNAGFEDFEVFLSNIADMKNLLFVNLSSELENEDVINLPKPHDREICWEKYSSHLRIVSKDFRNLENKYRNLTLIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW26</accession>
    <name>A0A4Q9LW26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0583p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000583">
        <property type="protein sequence ID" value="TBU12928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0583p0060"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="131" mass="15127" checksum="EE0A66941386D52E" modified="2019-07-31" version="1">MTWNSIVTEYHKTYVKRLQTPMNIEAYIKSKVLKKTVETISFDDKVELCLSQMPKKASLSVIEEAETHKQPRTPLKRVDNEEDDVKTENTKNITPLILDGRNPVKEPTININEESDLAEDNEMIKIEGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW70</accession>
    <name>A0A4Q9LW70_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0911p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000911">
        <property type="protein sequence ID" value="TBU12071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW70"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0911p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="364" mass="43542" checksum="6648D7A18565D24B" modified="2019-07-31" version="1">MIEKRLSNHERYYKRGFLVFSGNLCAFEDKNLMFQSMIDTYSKNDSIYLFNITLKKSINKSSMINIISEQYARCCLEISRFERKNIAKKKNFASIKYQKIYKKESALYRLKSIKSAKDLFEFLKKEQKWNPSSKKTNLKYFYFLFTDILKSYERLIVYFCFDFYKIFELCGDTTLFVSVENTNSILKNFQNIFKPKNNEPSLISVFGYYFQPPSNLNYSQTENVQNNDNKNLTIDLVKTEIFKSDESSKLPLHYNISNLSDHFANLNPQIFNEWILPDLRVMSSIEFYKPKILPTERLIKKLVFKISIPNFKDCNVSMVFRFNRYQLVSFSYKKYLQYKLIEQQKYSSMESLQEIFDSIIKDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW84</accession>
    <name>A0A4Q9LW84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0565p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000565">
        <property type="protein sequence ID" value="TBU12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0565p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="553" mass="62229" checksum="5B735A6A4A5EFDC9" modified="2019-07-31" version="1" fragment="single">MYEDNNKKSLNEKSNNRKNMDENESQEDKKDKCGGECKHDNTKCKECCGKSDSKLNNINENNVVKKVCDDSKDSIGTSKVKKKRTLILTCKEENLVLDSEETNVGNESDQSCSKCGKEKTKNKMCCKCMKKVEKRVIRAALSTPKLKKINDDFEISAKKKLYETFVSESSSYEVSEIHSSDSEEWGLDYIEECIEKIKPKKEKIKEKIITKKTDVNEDKKFDEDTESFWQHSDTSKIFSSFSEEEEEAEIRSRSKASTDPEISDLLRGENIRDDVFTSSNLSTQNPIYQSKESEENRSFESLEEVDVESFTGKNEKEEESLSNNKTPNIILYGSENLKIQDKKGTESDHDLTCTKENGERLKNEKEVETIKTEKKEEKEGDDAKDDSKNNVKPEEIIFIEENGNGKILGLESDQENENTNVITRNEGFSGIFTSLGLFFAGASIATTAQKNEHHKPSRDTQSSPELLDLLDSDSLAQNSDENNSNNKNIAEEISSSEKSASGANGSDENISTKEVSVSMAEVKKEPGELLKNTNIYENVDGSSLSDATKSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWB3</accession>
    <name>A0A4Q9LWB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Srp19-like signal recognition particle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0455p0010</name>
        <name evidence="8" type="ORF">CWI38_0578p0020</name>
        <name evidence="7" type="ORF">CWI38_0861p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000455">
        <property type="protein sequence ID" value="TBU02556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000861">
        <property type="protein sequence ID" value="TBU12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000578">
        <property type="protein sequence ID" value="TBU12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWB3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0455p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0578p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0861p0020"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU02556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="133" mass="15609" checksum="F70D1ED5BD7F2C4C" modified="2019-07-31" version="1">MSLDKESFCLYPVYIDATKTQQEGRKYNKTLCVDKPRFKEMSLAFKKLEIECIEEPEKKHPRSYFTNGRFQIKKMYGKKSVVNTLKGVILQLREEIKKEEEKKLKDEENCSANKGYVKNPLGLVPKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWE6</accession>
    <name>A0A4Q9LWE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0932p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000932">
        <property type="protein sequence ID" value="TBU12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0932p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="199" mass="23391" checksum="12AFF4A9099A4B6C" modified="2019-07-31" version="1">MIEFIRTVLLYLPTLYPDSITSFHYSEFILLPGQPFPPTRSEDPNLITTKNSNKSLLHLTYFRSKTKNNHFDPYPNPEPVKDKETPLTNSVSVRDSTWVRENTSLNNNRTVGKKMKRKVRETEKSRKTRKKLGKKKVCYNIKKNKICIGKKLIIYHLVGKRVTEEFLETFLVKKIRSKNSIGTINNYLMEKRDRVREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWG0</accession>
    <name>A0A4Q9LWG0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0869p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000869">
        <property type="protein sequence ID" value="TBU12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0869p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="52" mass="6152" checksum="DDB090ADA42EF9A7" modified="2019-07-31" version="1">MMVFTIYSSTRNNSLQVSLWYCEDHTIEEITAHEEPAININEESGLEEKRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ8</accession>
    <name>A0A4Q9LWJ8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase III subunit RPC82-related helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0644p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000644">
        <property type="protein sequence ID" value="TBU12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0644p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="499" mass="56012" checksum="5420D780B874F775" modified="2019-07-31" version="1">MVSQPTKLPFGDISSKILKFLKTRNTATLNQIHSATKLSIKKIVNSLSILIYNRQIKYYIFNGKTFYILNSCEYVGWVFNDFYVKYILKIVDFNRDFYKESGDIEMYLGVVVKLVCSVGVSCDGLSSKEECFFDSLVLYGFVKSVSLEEIIDICKYNTNIDKEGGVNNKGSSYKGVNRVDSYMGVNNKGNSYKGVSDRTNNIKGVNRVDTYKGVSNSIHNYKGVSDRTNSIKGVSNSIDNYKGVNTTIDKQHPVNNLFNNYKGVNDYDPPLNIDKISSKRLKGVKYYTLDLQALNHSILIYEGCKYIQKKYCKITRDVFSCIERSRGGTVSTLKGILPYNLIDIEIAVLLLKGVNILIENKGINKEGYVVNKGMLKHLIKMDILKGVIYNTSVIDSTISDITFEGVSDIDVVKGGVIRVLNMIVDKGVLEDSSVVRSSLLSSKVLRVVQCILLKIGMINLGVKDVIGKACYVWEECFDKGCYIIGNELSDNREKLILMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN1</accession>
    <name>A0A4Q9LWN1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Helitron-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0888p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000888">
        <property type="protein sequence ID" value="TBU12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWN1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0888p0030"/>
    <dbReference type="OrthoDB" id="2287175at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="266" mass="31306" checksum="FDA4DBBDC0FF0E13" modified="2019-07-31" version="1">MTCNPNNAEISENIDVNEKRENRPDLVDRVFRQKLKPLMTDIRRNIIFGKVNVYCYVIEFQKRGLPHAHILITLVENYKPRDSALLDKIVSAEIADKNTHPGLFSIITKNMIHGPCGFLSYSSCMVENICSKSFLKKFQEYTVLKFDRYPLYHRRKKNSVKILKNHVYNSWDIPYSPYLSLKYNCHINVDICASFKTVKYLFGYAYKEFDRANISFQFDEIKNHKDSKSVSPHEAVWRIFKFSTHEESHTVEKLAVYLEAEQNILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWN2</accession>
    <name>A0A4Q9LWN2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0513p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000513">
        <property type="protein sequence ID" value="TBU13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWN2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWN2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0513p0050"/>
    <dbReference type="OrthoDB" id="2196204at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="344"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="416"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="645" mass="75363" checksum="B606A9CDBD17765B" modified="2019-07-31" version="1">MEEEVQMDDYDILRKKFRIACPYEYNVYFGINIDKDIPNELQTRSINEATQDFRRVLIDTGIISCTKILRNQVKIILSNKINDVRINPLSLLKKGYRYFYKVSVPLCLYLYKKDIENKISDVMRDTRCVIRLCISDTVQIIINGPEEDCLNSRVRIIEFLESLMGRESVVTEGYFPISELVNLGYRVFYSSKINSKKVFISGKIEDVRNLKQVEDIRRSYIKSNYILDTLKLNHLIYYEKNLLEDILCSTDCYLEIEDGFFDVTNVSIVGFIPEKIVKCRKKIERVFHGIAKALIACCSATFVTQKIFIFEDVSKIYTKESTNKRFLAVGSKKDLKDFLSEINADCEIEIELDPDLEEFMCGKKNGKINKIIKDTECEILIRRKFEDEIRKIVIFVSGNSINATFAIESLENEFPAELAFYLNEKHHKRIIGFGGKNIQRIMKKHGVYIKFMSENERALLGLKGNVIIKTPKKNSASLEKMKEEVLYLADEKKIENLYTKVKMDLFDFYDFSFYKYKILFDHASVYGNFSNNVIYYKSNIDQIKALAKERAVVIRFNKGEHLFIKSLDYFPGEQIDTKDWYDSQGVFSFKAFNSVLLYSYESLFPTEKQDTDEEINFSERLPKHDNIGTIFSVGFQKNDKNQRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXA3</accession>
    <name>A0A4Q9LXA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0444p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000444">
        <property type="protein sequence ID" value="TBU13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0444p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="106" mass="12694" checksum="3EE1D511A16FC433" modified="2019-07-31" version="1">MYFFTILFVQTVFYSKILDATPRDMNNDLENFKYSDVKLLEEKNRATFESKESECFHIILTNRYQDVIDDISLVMPDFKVILEEHVKLIKPIFEDSMQESIEEQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXK4</accession>
    <name>A0A4Q9LXK4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0406p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000406">
        <property type="protein sequence ID" value="TBU13519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXK4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0406p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="16926" checksum="C70A5AFCDB01B66E" modified="2019-07-31" version="1">MYQNEPRLPAASIFKSNDVIKTITSDFHGENSDESCYMRKHSKDSGAFGWCLYILDVHTKFLYEISLQTKQAASVMSSIIQTDNRNKCGSERIKQACVDYIISFITLEARHPQKQNKLRDVIKTIILKLAINLRRFNLKRWFDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ6</accession>
    <name>A0A4Q9LXZ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0632p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000632">
        <property type="protein sequence ID" value="TBU12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0632p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="442" mass="52431" checksum="9C82F1A63A3DB3BA" modified="2019-07-31" version="1">MQYCTLRKNPNTKNLGKNGSFGKYQDKSKVILRFLLCFMLKNQCKCFRIEGTFSNEWYSTKTRPNISNYDLELNFIQKELISRCSEANKKEEINCNKKRIFSEIKDNQSDYTFQHRNISKSDKNVEWITKNEKSIVFDYSDEFIIRSKYLNNLPKSEQNVCKCNISEITKTNIDIETFEIFLFVLHFGYNIKCLDLKKEKFMDFLVIFSDLICYAESNVIFGLYKHLISLLVSYKNDILNKFPNEIEKHIFSVNTSPFLPFLSTFFDDINVEFDENINEVLFLKNTNENEIYYFHKTIINDIKIRTTPKALILIENQADFDAELFFWVIFSYKINGLKISHDNMYYSECYEKDKDYIENNLPRESLTPKLFLFSSKVLKAIIIMKKTQIRYLELERVTLTPYDICIMQNLNNLESLILVNCILPLKISFFLNCVGISYNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ8</accession>
    <name>A0A4Q9LXZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0013p0060</name>
        <name evidence="3" type="ORF">CWI38_0357p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000013">
        <property type="protein sequence ID" value="TBU05430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000357">
        <property type="protein sequence ID" value="TBU13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0013p0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0357p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="2161" mass="259467" checksum="0FF1871160213D29" modified="2019-07-31" version="1">MSNTSIISDVTDLSNFKKDISMIYTKGYILTEKNLESLKKLKLKRRSVSDYLSIIKCLEKSTEDSSDAYFTNEIQNRNFQKNNKTKILFVLYSICAMLLSSYNLHLYNPNRIIFRLVNSFDTEVSKSALELLNFRYSDFPSLSDKNYVTSNFNLDLFFNEVKFSYFKYLTDKNYITSLEIPEEYKNMKKHINTELNLDTYFDTYVPYIIKLDKEKAMKVILFCKIQVFLNDKKNFISSLLYGISLALKILPNKFKPSNDAYYTVDVYSLTEIIQTYYKEDTLIRDLSIQILEFFFMSQFFVSENKICLRIYDKELLDFVNKKSSNSLTEKIIFVFNFIKESDNGKMKFVNFIAKMRNSLEEKQTKENFLNLIFSIFKFHEFQLQGGDNLFKEIIVLFYNELNFHNHALKTPILDVHNQHYNSLFNTIHIIFKNISFDEAYKLEIINFLKIFYKNNIRFFNDTVKFSFIKLFKFLDNQNLNDIAIYQEFTTFFNEYFVIRKQYLLKHYEIFTKCILELRNVPEIYVKCIHIMFDVFTCTDFPFIILWEKKYSEIFNSEIFNSEILWIFKNYFNQDIWCLTIKKLIEIALVNERKYFIYNQRSLNYYGIKKKSFSSVNSIFTESERLIFHEFNSKFSTFYQFLYSNYINFIDDKAVKIDSIYMDIFDLMSSYFSFDKKINIRVLEAIDSHISNKYNNYLILESIFLEIERKIIIFEKIHNQKTFSCTFDVDAIEIFCRIVRFTDFFEILNKDTNLFTKERCKIYLGFFKTYLKFISRFYRKHDYLRKPKNPLTEQKPGNSNLEDEEYKQSIFEKSHELSYLRTLDFIRKFKSYPIESGNESPENLVFEEISSMLSDSDFYICDIVSLVLEYLNCTDINFIKNQLIFFFNNLFSVLKKDISNFKDKNDDLEKATEYILKIYRNYINEKYFSDKIKDEISYKIVLYFAKYFDKTSIHTFLVLSKFLKKYKYYSSLPGFNDFLPDSFFLKSFFNNTLNTKIYTCIDYLVGYKDEDELQFNFYYDLFHVNCFYFISKAQYKSKIVFLMIYQIIFLTEFDSQLFDCEGFFDMIATNLLIISSQKYLMNVEKVILNSFIKTISNKKISNINDRNNVSYDDYCDFYISILCISERYKLFTKEEIFLQIDFNNLISIIVNENISNDFFKKVFILLNFFIYDNEFNKKYFLFLFYSSKDDSYKEMLFKRCFMNINMKGESKKFSKFCDYLDLSGNINMEDKKYIVRLLLGKALESKNMNILLYLTRMFHLMPNLVRFIPKIDILNHFFTFILQQSEINILTNLNQFEWHLNYYGELFLTRIIYCQDRCLQYQIVEIILVILQNLIDSIMNNRGDISFEEIKNEVCSKISFESLCKKRSENKKIEPLDVKKECKRDFPIEIKDLNEKKFDGITKNNILIILKLIYKILKSKPCCCKMCLKIFKMDENSLKKQLANLFIENGILGILQNIFFMKNTDFDLTEKYNKYSSFIVNEMLIILYQVKKFSSRTVFHSYFPHFFGDLFEDIPCLPAYLKKTDLTYIFCNLISGVETKKLDFKTYLDFVFDFNLELDSFSKENPKSSKNPDNSFKYYKSRFKITKLNFTVEKKIDYKNLLSHFFINFLDPNKVSLTKDIINEKKLRKNNRKLHNDNPSFIIESLYWFLKCNNNLEIKYFMFYHSNKETLINYKEELFKTIKKRNIDQFVRNHLEGFNYGLEDNKNTKSPNSLSINPKIDCSSNESSKNIADQISSSSSYETAESSLSNEKVETDLDTNIDAYPCMDFKCFNRKYFQENKNEMTRIQDKLIFYFMNFEKDIFKCNCKNGECIYQNTVSSDMVLDYSFLFACGYCLNTALGKVSFLNFINFVFEEKDFYLKKKNTKDIGEIIESVRERYSEFKLPEINRKISILTYVFMVYNFLHFDSLSLQVIRFYLYDNFHFDNSFSKISYLSDYSEDFNIRKQILKISKSADKSIISQKVDSNCNLLLFKKKPYLYLEEKEFELFIYFKYKYCKNISVYLDCLCKIICYKMDILFNEFLINKFDMKKFSKNEIIIKILDEISKIIGMEYKNIKSYAFNEELIQEILSNNFWPVISFMVSKNCEKAREKEFDTLEALLKLVFFCYDLRKHLNYFTKKMIKFQNAYELIVKRNKNTAIYTLNKSKNNEVSMFYLMQYGWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY91</accession>
    <name>A0A4Q9LY91_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0352p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000352">
        <property type="protein sequence ID" value="TBU13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0352p0050"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="277" mass="32984" checksum="23BF4A35DBE89A14" modified="2019-07-31" version="1">MNNLLNILITEIKESHEVPLVVEWCEEFIRNYYKNNEYFESMLVFYKKNQVKCSEKHEILNICINLFYFGYDITNNICYNKYTDLDERSIHVVGSMVCWAAIGNILRKNFNDVLYLQLTEIFDDAGLYLNLPNNRNICLNFHMSKLRLNFYTKVYLPLKIKDALNCENNGNNYNKYENIFCFSYLNKEFRLKNLKKEELFDNFSEYLKFFSEDIDLGIIMDKIISGLYIRELELPEIKIHLKTWKNRPDIFILATKTLVDVGITSQDSLQIIKIEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY94</accession>
    <name>A0A4Q9LY94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit 10 of anaphase-promoting complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0370p0030</name>
        <name evidence="7" type="ORF">CWI38_0458p0030</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000458">
        <property type="protein sequence ID" value="TBU13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000370">
        <property type="protein sequence ID" value="TBU13654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY94"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0370p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0458p0030"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15590" checksum="DAE1E723E0D155FA" modified="2019-07-31" version="1">MDIRLSSFKRGHGLKELLSSETEEFWHTDDNLPHYIQISFNKRTYVETVQLLLLYSKDDSYTPEKVEVRTGTTTETMSLSTTMTFIEPEGFVNIDISSDCFILQIIFICNHQEGRDSHVRQLKVFTHGNKEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY97</accession>
    <name>A0A4Q9LY97_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0655p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000655">
        <property type="protein sequence ID" value="TBU12720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY97"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0655p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="808" mass="94829" checksum="A9A66245253B7C8D" modified="2019-07-31" version="1">MTGYIKNTGKNQVVSISNEEIDNSLAERQMRCQFEIEEEVAAKTVKKNGLKLRECVETNKSSQKDDFFRNNEFKIMIGLHKNDSGLINKNLPVARFLIKKIMSNEVLEDKRISNIQNISTDTLNGEARDEKSVLSVSEIAKKYICPKASVEKIKYFKDKEIEKIPGDSEYHMAAKTTNTFSIVPYKVNKVENQKRKRAKRRLTRWIKPEEIVGLKENVKPENKKSLDSESIPLNRNVKNIMLEQKSVLNYQNLKKEEEFVHCNVSGELEKGRENNNYTIQKFFIKEAKKINIKKEYNNWDKNHSDKQEMESDFKIRSNEAKIVPIEDEGIEGSQTEKIIQQNKERMGNLGCKIINELEETKKVLSIVHLNIDQNKEINECKKAFENFESENKNSNEEFFIDKILMINSSNIIALSKETDSKQCSDNNFDGDYSKKECLINVINEKTKLVDVQAELKEEYCIGTEKDTNKETEYEFDGSECKMDKNSCLEVENFHQPNNREIIPVDYSVKREYTGNEKSESKNMIRRSEKQEILYKRVLKQIVSRENVYIPPYNKKRMLKKNILTFKKSDVMSVDTSLLDREDRIKIEEHYRKLLDRKIEQNESGVKKWFKSLFGCYRIKRNRIVNSIDNFIFKLIDFLIMSNISCTYGFIKEINHADVKEKIKKIEKQEYYKIEETNVLTNLGVVLFYIRETMNGIIPHHYRKILLNKKLKNDKKKLDSILDLMKFAIGYERIKMIEKIKNLIMNMKCNSEDPKLVGHLIDIFSKAIFPLKENANLKNDIHVLNVINFIFQSDLRSISLCTYYEARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ4</accession>
    <name>A0A4Q9LYZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0380p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000380">
        <property type="protein sequence ID" value="TBU13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0380p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="208"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="396"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="982" mass="113300" checksum="DDADD19030AA7EA7" modified="2019-07-31" version="1">MSNSFSGKNTNENKYDFHVGETQECIECENDNVLKCLVETSGLHDENHPLTPIPTLRKQKVSINDRERIIEKKLESYSMSAIASMYRINYQTVNSIVRRYLKTGLVFVEKGGGDRRSKLSLEIKESLQAYVDLECTKTLYELAEWVKCTFNVYGSTSTIDRALREFHYTLKRVTLVPERRNTLSTIELRTNYATSFRELEVDNDDKNFVFLDEVGFAVVTRPSESAYLSVTAARSRNISVVAAMNKYGMIYYKIHKKAVNGEDFKLFIKEINESCQRQGILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVFSVWKNKVIRGGARTEPQLRILICEKFNEITGEHCSSFYRKMLGYLQKAERTPQADWYYCGLTYLIPKGTPKTGSDYRPITRVSDLYKLTTKCFTKVVQVEVEGRGLLAENQLGATLLNIALNKEYGNNLKATWIDVTISKWKIDISVGSEKIMNKKIDKRILQGDSLSPLLFVLCMDPLSRKLNEEYAKVTIQTEEASNSTNHLFFIDDLKLLSKDSSTLSAMKGEAKEFLMVIELEINKEKSATNDTCCEDTATLLEEICVYKYLGIIEDSRGIPTIERLCRTRLNARNLFQAINQHAISLLNYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKKLEEAQLANQYNEIKNRKLHSKLYSARNNELVSVNDSSRWLKKGSVRPRDEADRNVFWSAEGMCQNCNQSRKTVDHLATRCEKILGHNYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILYNEYAEIRVDTRIKTDVNIRCNRPDIFVSDKRKNKIPLIEVGITSPKIHFKHELAGLIYKCSVEIISYGITWDGIITKYHNMYVKRLQIPKNRALLTVILGARCCKTNKYRKYYTLCLDGVTTVVEPTINKNEESDLEEEIKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT1</accession>
    <name>A0A4Q9LZT1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0291p0020</name>
        <name evidence="2" type="ORF">CWI38_0469p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000291">
        <property type="protein sequence ID" value="TBU03461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000469">
        <property type="protein sequence ID" value="TBU13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0291p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0469p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="152" mass="18831" checksum="63278377C506D1EB" modified="2019-07-31" version="1">MTFIKDFERSYKKMYFSKRNRDVYVKENEERHVSNIRSENALLKASDRFFHEQKSPETYRESYSRNTRKPFIYDPRYRAEKSEYFDRNEKYYITQSNRPHYTDRNLIRDEIHLLPKRTKPGSNCYYDSEKEENSLFYEAAQGLLKLYYYQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZT2</accession>
    <name>A0A4Q9LZT2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0186p0050</name>
        <name evidence="6" type="ORF">CWI38_0486p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000486">
        <property type="protein sequence ID" value="TBU13257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000186">
        <property type="protein sequence ID" value="TBU19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZT2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZT2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0186p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0486p0010"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="11355" checksum="D5FBC84A3B90D02E" modified="2019-07-31" version="1">MTKDVKLISYDGIEYIVPEEIATQSSTLKSFLDEENPFIESHEKTVVLPIKSNILKRVIDYLKYKYEYKDTEGTIPDFEIKDDETLELLDVSSYLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZU9</accession>
    <name>A0A4Q9LZU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0195p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000195">
        <property type="protein sequence ID" value="TBU19815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0195p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="12841" checksum="4A3AFDCAD8DB05F7" modified="2019-07-31" version="1">MKVKTHNRGKSALKQSNNHGLRQVDLTNLLAADPSKYEKNGLTEAIHKLIMPEKPNTVVIVFCKRKENTTAVSDKIDHDRLDVYAEYNRQSLGGLQELSTDDDYFYRVEYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M002</accession>
    <name>A0A4Q9M002_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0182p0050</name>
        <name evidence="4" type="ORF">CWI38_0646p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000646">
        <property type="protein sequence ID" value="TBU12741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000182">
        <property type="protein sequence ID" value="TBU19875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M002"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M002"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0182p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0646p0010"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF79">
        <property type="entry name" value="CHITINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 19 catalytic" evidence="3">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29181" checksum="156E9DE6CDBF8683" modified="2019-07-31" version="1">MVLNKKTKILQNGKDDRVKEDVFNNKLDDVPEEKTPEKHNFFKRFYHKLFPKKNNLITSKEIFDAISSCGFEPPNTLYVTELCRSMNDKIQNKEESAMFLAHIIHETGGLKYLEERYAVENPDFDKQIYDDGMGRKDKSYHGRGFLQITWPKNYARISNELGMGYKLLDEPELVCTDIKIAADVSACYWLLFVRPYPNVKKKYFGATTKAINGAVENGKNNVEISKNRYKIYLKVAKAFNIKKTASEKGCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M005</accession>
    <name>A0A4Q9M005_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0370p0020</name>
        <name evidence="1" type="ORF">CWI38_0458p0020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000458">
        <property type="protein sequence ID" value="TBU13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000370">
        <property type="protein sequence ID" value="TBU13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M005"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0370p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0458p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="112" mass="13098" checksum="995A1B7FEBF8E46A" modified="2019-07-31" version="1">MKLKAYIQFIVFEKAIETISFDKRKKLYAICVILGTRMDKQPTPLLTQVDNEEKNIKPFILDGITTVKERGTDNKLNKHFEKYKKRIIESKDPNKTIRNLLIGDKVLIKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M087</accession>
    <name>A0A4Q9M087_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0279p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000279">
        <property type="protein sequence ID" value="TBU17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M087"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0279p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020850481" evidence="1">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="9992" checksum="3C9486C9E6D18B0C" modified="2019-07-31" version="1">MKIPNLKNLRFRSCLLNLNLHLIFGAIYPDSIIDGIYICDSEISGKDIKYISTLKVKALILIHTKNTLSEVSNNLCDDVIKQTSDGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C5</accession>
    <name>A0A4Q9M0C5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0142p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000142">
        <property type="protein sequence ID" value="TBU20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0142p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="777" mass="92430" checksum="2A3FB392AEBB8151" modified="2019-07-31" version="1">MFNIGSLMRILINTNLYFGSLLIILTLRCIITQETLNLIFFEKNADKALTSESIFLESYLCLDSLDGKYKKYYRISNCKILETFVIDMDAFPLKFPTESRFGEKNDQNLYISANIITFEEFFYFYKTILEFPYLIDNINEEKYLLFIKILNIFKFERNSSFKNLIRFIWCSIIFNSVPIKERNFTSKKLQNYDLPKYIDLSKMVLVEILEIFKFSKEAISIIKDISWAKSVTKYYKFDFININDKFLYFDTNIIREFLTRESILNNIFTIIDIFNQIHTFKHYFLSSISYTNDLSKFFMLSFFKGIDEIYVAFSSNTDEIIEKICQTSALKNIKILNIIHSEFNTKDEIIFLKKYNIEKINYIVSPNAPKTYFHNSAIQSSVHDIYSKFIYEISENDIKVFAYQNRKLNKNIRKNFILVFYHNESIIEKVENLNSLSSMFLSVKLYNEHFWFKFFSYNLKEIKNIDVRFTDTYIKDFKLNNIEIFNKIIRIFIINSKLTATFLSRILLFPFLREVNISDSKVIFSNTQQSWIDNSSIQKFTLKNTSIDNQDLFIIFLNKITDMKNLKYSRSETIIFSNIFISCLNDPILNPTNLNSLKYYISYYSKRSIPFFPMFFHLKKFNFGFDYPEGTLLQIFLSQECNNLQKLKIFGVYIGKKDKKALGKCTTLNYLNISNTCRFDEIDFCELFDSRQNYIINELHLPNIELSNCDLIFFSKLKSLKKLYINSFKLKGSFNLILQSFRHVNNFEVGRILVSKEEISKLYEEFGMRIKSAVFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G8</accession>
    <name>A0A4Q9M0G8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0407p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000407">
        <property type="protein sequence ID" value="TBU13515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0407p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="17253" checksum="5A43BE113CB7C236" modified="2019-07-31" version="1">MQDLKRFRIYDCRIDKRDKHLFENLTSLIYLEIENCKFKNIKFNCLFNSEKEYVIEELILIKIELYRSDIDLITAFKHLNPIVFDCCYTPDKCFLKIDSKYILKLEYLNISYSVSSNFIEEKNHLLDQMSMNSLIITSHSYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0H8</accession>
    <name>A0A4Q9M0H8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding subunit of chaperone protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0390p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000390">
        <property type="protein sequence ID" value="TBU13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0H8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0H8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0390p0010"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="4">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="300" mass="33524" checksum="04BDE8FCF52AEB19" modified="2019-07-31" version="1" fragment="single">KSRIFGQDTAVDTVVRCLLQNRVGLSVPNKPIGTFLFLGPTGVGKTELAKALSYELFDDEKNMVCIDMSEYGNEMSVSKLVGVSAGYVGYGEGGVLTEAVRNKPYNVVLLDEVDLAHSRALNLLYQILDEGRVMDGKGVVVDFTNTVIIMTSNIGQNEILSSKNVEEVKGIVENKIVEKFGMALFNRMDGVVYFNVLTIEVMSKIFDYNLNQMNKRLKEKKLMLKVSDRVKDDVLARCFNQFYGARPLKRYMQKNFMDGVTRLILSHGSEIEKGIISCYCDDEGIIGEIVGDYVYVLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M184</accession>
    <name>A0A4Q9M184_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0077p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M184"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020441051" evidence="2">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="10658" checksum="DF29CA47262B0133" modified="2019-07-31" version="1">MFRMECLLCFLFYITYICCNKNAGAYQRSNLRANSEDSPNGRSQMFGDLNGLGPTPLGRPYGSLGTGSGYPYSRNGPANKFKKEKGVISSLADVFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H4</accession>
    <name>A0A4Q9M1H4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0194p0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000194">
        <property type="protein sequence ID" value="TBU19818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1H4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0194p0010"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU19818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="385" mass="44586" checksum="A88458D79AF117E7" modified="2019-07-31" version="1">MDSKQKITPWEVTGEIVEGKNMAVDYEKIIKNFGCQKIDEAILKRIEKIIKKPVHHLLRRLLVFAHRDFDKILDLVEKNKKFYLYTGRGPSSQSMHLGHAVPFLFCKYLQDIFDVHLVIQITDDEKYLWKDLSLEDSIKFGKENMKDIIAFGFNPQKTFIFSNIEYSYKFIKNSLRISKHINLNEAKKVFGFDSTSNIGQIEFPSKEIAPCFSSSFDFLEKNMMCLIPAAIDQDPYFRLARDKAGILKEPKPATLYSGFLPDLKGLNTKMSASDTKSSIYLTDSDSVIKNKINKYAFSGGKDTLEEHRKYGGNIDVDVPFHYLKYFEENDEELEKYRTGYLDGSISTGEMKKKCIQLLQKFISNYRKARENLTDEIIDKFTAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Q3</accession>
    <name>A0A4Q9M1Q3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0238p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000238">
        <property type="protein sequence ID" value="TBU18511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Q3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0238p0010"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="740" mass="86333" checksum="D2A3C7E81D5E3327" modified="2019-07-31" version="1" fragment="single">MIFLPQQNIGMYRSNEMDQFRFCSGRHFFAENRIYPEFFVCPHAFSFFNHEPLHIFKVDYKNEWKIQFRVLNDHIYENLNKPFLFDGSFDVSYPLFSIFAGYMSCDSVVMSENLSYEVFYKLIKILDILRPISSESLNKFYSSLYRNGLMNSIVFADIVNDAHNYRTRYFNQTRPQEAFMYFFGVLNASLDACFIPNISVVSIFRKRNQYIDQCFRYTEEIQNLVLKISADSLELLMATPSFNMAIFNWLLSITKISGFYFDNTECSFNPIKCPNVCGFIKINVPKKSPNSLKAISSTFLLNLSDVNKRRIAHLRFINVDFCFDKIQNIFKENNVSYFEVAYCSVDECHKITEFLLKMTEQNIFKLRGVEMKPDDVDRILRSKVRILVLDTCTICKDTVWTPNKSPDFEYEIIHYLQTLNVSSSKLPSDLMQLLLHSFNLENLNFSCFEFLPANSSSSMIGLKRKWNCLQIDKYIPSDYLKNLLKEYSVYSLSLCESFIFNDIISFFNTGYFNNSVKTLDLSDNSLTVDFLAIIDNFKNLKRLNLSASLPLSIYSPSNYRFFATLRDLDVSRNNITSTNFEFLACFTSLRSLNISESKIEKGLFTKMLTVELIASLVSLDLSGVHLEFSDFKRFLPCKKLKCLYFKVANDRSLSYYVDILVFTAIKKSLNVLNVEIDRNISIDDLVSLNGLSNLSEVKIICNAFLFVGEENLIKFDFFNPEFRLELCLRHYNLDMYTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S6</accession>
    <name>A0A4Q9M1S6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0035p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000035">
        <property type="protein sequence ID" value="TBU20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0035p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="687" mass="79888" checksum="EBBF68D3AC7330EC" modified="2019-07-31" version="1">MQNSRLDIIPSPTTPLPSSVEVSACEQSMPRMARKLHKYNCEKKLAQSEMGKEVKSEENGERRRNATFSLIHAPCPTRQKHPNKLVDSKVLGLINRVVGECAGNHVPYSITETAYIRQAAQVCYDEATQENIESKISKLLFPSETKRFKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKENRMFELFRGRFYRGLSERVKSEIVVSSDEIVSFWSTMLNKNTDTVTYENYLIPFVSDNHPTMFLLLDEFEALLQNNTCIFNLYKLTTKCVTKVLAENKLVTVRDQTYKDLKDFANFSKLDDVVRTSSPRIKDLASEHMLPRLLDCLEKGKETSTRRAAILKVKNNNKTHLSYRLVEEVTKKSLEEAQLAKLYNEVETRKLHSKLYNARKNELLSISDSSRWLKRGDIRLRSEAVFCYIQDRNVFWGADGHDYTRLNNEVVRYLHIVLLSKYKFKSSKRIRSHPEQEIIDNEYAEIGVYTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSKDSLQVAETEKLRKYDLLANDLGLIYKCSVEIIPYVMTWHGIMTKYHKSHLKRLEIPMNLEAYIQAIVLKKTVETISFDRRRGLESGLNAEERWERASMGVIMRAEMHEEPTPPLKEEKREEDGAKNFKPKNKAPFISQRGTTLEEPTNNINKESDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1S9</accession>
    <name>A0A4Q9M1S9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0174p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000174">
        <property type="protein sequence ID" value="TBU19918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1S9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0174p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="256" mass="28821" checksum="C847062E77A41976" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLYPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYYMTSPCTLAIREDNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1U9</accession>
    <name>A0A4Q9M1U9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0031p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1U9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="781" mass="92845" checksum="FC73C624942F64F3" modified="2019-07-31" version="1">MKKNDLKISSVLIKFLLIRFSGIFSRKIVFYYIETTSIENEKKFNKNEVLYEFEITNNKILKKFKYVYLLKDETLQFKTKKDKLAYYSPKKIEISSQDLIIDIFMSEEDKLNAQDYRKFLGQIKENVLLRFIKYITVKDTILNVGIEELINILLLLETLGIKMTKNNTLFLKFLSFHSLMNPNFDFKPIEALQENDKYKSIYNASVLEYFYRVFRKFVYMSDVHSLFLTLKNEALICEKDSILSYEKYVFRKKNLMKSNIFRISSLEISKLEKILNMTWCMKSCIFFVKYLKIDIFLCRINQKCPSECILNFINLVKPDELSKLILIDESYTKSIFEAFVNFGYLYSTKFVKIICNLTLIEIRLVLQHCANIKTLHLKGYQGNYDILFELYCYALTNNNIFIKYKPSFFEIQCIKEEKIEKLPPNLAFYVKNLQYENESCESCYLISLGHYRTCTMEYRSNFDIKGYKLGFKRCLNLKNILVFGSPGSGRFGLNKKILKYINKMPKLSSICFKQILFTENELNFLLKSDRIDFLKLDNIEFQNKKFSKYNTCNSSLRGLTISHTTKTFDLDFLYFLSLFSNIVFLKIYIFQVDLNLKTELYKLFPKKIYIKREKYLPELDYLKISTSYDIKVSFPILFALSHVFDLSNLQILILFIYDLDELDIKILSHITNLVDISVYFDKRDIKINLKNFYQVIQKNRIYKISISVYDLCKECINCLIHMKNIKSVYFMFEFITKENLNLLKKFKLVGRDNIKFHCTNDIIWSSEIIGSCKEMGIFLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y0</accession>
    <name>A0A4Q9M1Y0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0223p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000223">
        <property type="protein sequence ID" value="TBU18892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0223p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="346" mass="40977" checksum="0E50BB70C7499EA7" modified="2019-07-31" version="1">MRYNSQHFLLDEETLYADSDTKKKLLPKSRIEKAWDELSDYYAKRLEDTNRDIIESTKLSNKISQARLEMETYRSVDDLISQNILKEYICAEKPVKNLQGSIKPKICKMCISIADKYLKIFDEAVECENKINNILSKYNRYCSDQDNYTQKSYKIILSDGFIKIFVTQQIYILLNKNCEFIYPEKWLPTGLSCIIQYDGFVFKGSLKPQIFNDAVENVREYCEEREIILERKRGKLKIIIYQGFDTQESELCTFVLKSLKRKTNLDKIIDLSLLYLSKLFTFSLYRYIDVLNYEFINFTGPVLDDGHTEMFFCVSSSNKLRILRDLKKGNFEIHWNERKMIPKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y6</accession>
    <name>A0A4Q9M1Y6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0027p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0100"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="46" mass="5223" checksum="5B59ED9F71A554BA" modified="2019-07-31" version="1" fragment="single">KNFKPKNKAPFISQGGTTLEESTNNINEESDLEEETKVVKEVEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M216</accession>
    <name>A0A4Q9M216_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0148p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000148">
        <property type="protein sequence ID" value="TBU20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M216"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0148p0010"/>
    <dbReference type="OrthoDB" id="2198921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="155" mass="17811" checksum="429C144D87D166A2" modified="2019-07-31" version="1" fragment="single">RKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSYLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKTLKPKNNTPLISQGGTTLEEPTNNINEESDLEEETKVVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J1</accession>
    <name>A0A4Q9M2J1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0011p0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0160"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="226" mass="27028" checksum="C31BF6B172075237" modified="2019-07-31" version="1">MTYTATNKRNKQVKIYLNQESFETKIKEIVSDFKKIPHNEKNYEELYYTVSSYLENQLDGHKEMFLTKYKTDEIRKQFFEYMFRTSKNEIYIPDSYFLAPAIKYSVSKLGVCTSFNTSEEVFLKNIEKTGTLENNIIINYLNKLSDVNTSKDQKKSEILSEESSALNKTACIELKMNFKAFLDQQKTRRKEKHKKKNLNIYFPFDFNEMYTKFLNHNQTKILKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2T3</accession>
    <name>A0A4Q9M2T3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inorganic phosphate transport protein Pho88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0090p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000090">
        <property type="protein sequence ID" value="TBU20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2T3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0090p0040"/>
    <dbReference type="OrthoDB" id="2190094at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="19154" checksum="4E2E5B7BF95D0D9B" modified="2019-07-31" version="1">MDMSNTNILWSLRIIYVSSQLLYLLLLYIIKNRIISTNDTRKLKVKPEISFFQRNDTLEEDETVEISFKDYDYKEYSKILKGMLIQFLIVIFIHFKLSISQPLVIQSLVPFKSLFLNPLFIFYIRNNPILRPFEDNMLFQKTSKNEEKENVEKKRKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2Y0</accession>
    <name>A0A4Q9M2Y0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0053p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000053">
        <property type="protein sequence ID" value="TBU20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2Y0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0053p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="90" mass="10615" checksum="D55DF98F8499D248" modified="2019-07-31" version="1">MLHGKKQINVIDKRKDLVDKTALDRSYLLPATLAKKVSNTLQTYNRKEFLDKRITKYAECNICLFDWNASNSQNIERVERYNHVILNMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3J2</accession>
    <name>A0A4Q9M3J2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0123p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3J2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0020"/>
    <dbReference type="OrthoDB" id="2189500at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="144" mass="17239" checksum="2CB47E835625C6C1" modified="2019-07-31" version="1">MISFKDCFKLNLSDEIYYKKVLFFTVKENNVYSKVKMCISNNILYGIKIESDLKVELRRCFIELKKILPTVFDKKHILYLNNIYKVYKNKEHVYLSVFKILGKEEADKLEFYENIFEDFNISLDSSNNSLYDKNEILTDEIIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4I3</accession>
    <name>A0A4Q9M4I3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M24 metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0038p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000038">
        <property type="protein sequence ID" value="TBU20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4I3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4I3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0038p0020"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="240"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="7">
        <location>
            <begin position="435"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="500" mass="57746" checksum="F5762E544AD52F7C" modified="2019-07-31" version="1">MALILKNGSSVLYTDSRYFIQAEKELSNDFKLKKMGIDENIYEYVQTIGGIKKIAINYKNISYSRLNDMRSKFEKNGVEIVHDDLTESIWPNKPERTYNEIIDLEKIKANTFLDVNSNENITGSNYMDKINKLREKLSDDQVFILSELDSISWLFNLRGSDIDYNPVFYAYSIISNDKAIIFIDREIERKDVEIKKYSEFYDFLKVEVSDLIGELKSQKNEIEIKGFELAYINDGISLCSLFEWMENNIGKTEKTIADKLEEYKRMLSGFISPSFDTISAYGPNAAIFHHLASETVVESKNLFLIDSGSQYLYGTTDVTRTIHLGEPTKEQKHDFTLVLKGQLAAMRQVLPKEKDSSVLDTLARMFLWNEKKDFGHGTGHGVGHFLNVHEAPPGISQKGDLLKENQIFSIEPGFYKENDYGIRIEDLVVVKKDENFFKLENLTMTPLQLKMMDLNILNDDEVNFINEFNKKVGFVLQNKLEKGHGYDFMMRNTEEIKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M527</accession>
    <name>A0A4Q9M527_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0015p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000015">
        <property type="protein sequence ID" value="TBU20862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M527"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0015p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1020" mass="120453" checksum="DC998B6849AA627E" modified="2019-07-31" version="1">MTIFIILCSALKADSSIILHFYNEPNEHEKNSEHGKVNIRSFSKFIKKKHKCFEHTECKECVKYIIEDRNKIHLNFDMKSSEKKRATIFISTNVLKYHEFIYFLKVSNEIQDIKENLRFTDFSMLIHILDIFKFKKDKNFSSLIRVFLLSIIYNNQNDYEEDLIKIITTSSSVFKIILYEFCSIHFLVLDSDFRGISTTSFKKQINENFDDVICSDKKFLEINMEIFNKISKLIRRSQKFEHIFKIIFGSIKPLRVSLYYRELHDDISNILAPSFLISCEALCFENWKNMKFIEKIFESLILKNLKILFFLNCEFSFFKESLLKKFTADSRIYILNSSLETTLDFRKPVYSKESIEFLQRLVLKLYNEIRSKKNTSIFLEKNTGKPYKIEKFNINKYIETNRSVGFQEAFNFKDHNIYFKDFFSICENFVTIDFSVINIQKIGKICIRLRDIFINGLNFKSTDISENIVELYFYASKLTDNFLRDILTLPRLKTICISDCTLVFQKHKSKYAKNLSIDNLSITACDFENQNGVFEFINSMPNIKTFNFHSFKNASFYIDIFKNCRIELNSLENFHYGEKNKFSASYLKFLSTDSITTLQLVVNSKIGSLKELFFEKKLRNVTRFVIYHFKIGTKDKKAMVNCTNMNFFTLYKCEFDKISFFELFDVKKEYAFRNISLDHIVLKSQDVYFLSNLKQLRWLSLNPRFADNTAFIRFFCVNSFKPKLTLRCNQENLPGAYTDEGNNSTKVLSNEMTNLCTLAFLKIIFEPVNANSQMHEIFKQDFKGIIMRNLHPIPTDKCSLFLTIFKEIPENKIKEGVGKPNDRRVGEYGKVCVHGSADKAVNILQAVMLCYEEARQKEKYYATNYTFYRDTATSQEGLIVFKYLWDNRSWQILSTLYTFEKTRFNAKEISFAIDQQSISLKNYHIRSKKFLIITMGIRMDIGIKTDVKIRCNRSVIFILDKRKNKIRLIEYDLLANKLSVIYKSSVKLIFYVVTWGGIVTKYQYLYFKRPQISIDIGAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWV3</accession>
    <name>A0A4V2JWV3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2180p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002180">
        <property type="protein sequence ID" value="TBU09132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWV3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2180p0010"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="101" mass="12015" checksum="F777B5D2F2801A66" modified="2019-07-31" version="1" fragment="single">MHEKIIEIIKEETKRLIDSKITKNFVQRLKFYEILFEMNTSSLSKNVREIFYISPNVFLNQNVIVTMANNFIKKYNLTYEDLLITASYKGLFCGPIEIYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX27</accession>
    <name>A0A4V2JX27_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1954p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001954">
        <property type="protein sequence ID" value="TBU10192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1954p0020"/>
    <dbReference type="OrthoDB" id="2189352at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="514" mass="60944" checksum="B31BC7F016736D51" modified="2019-07-31" version="1">MSVKHADIKILSKRNNESDLNEKKDSKTRIRVLNKKTDEQEKILKDKTKNKTNEISNKIFKNKKDISKNSKFKKLNNNSNKEIKRINYESKNNFMIKDQSITKINYDKTVEKSLKNITSVEKEILKRGTIKNKIDLLTLLITQNRGNNKENLQKLFEFCENERHSIILYVIKNFKDLLISNKNLFQQNTEYSNKFFKILEKGLKNEFISNSIIKIVYDLLTNEIHVDGLIKIFVNKIGGKKIVSHFVCYKLTELVKMNKNKENRNKILNEIYEYFSRDTVLKARVKILKIIRNLKFDEQEGIIIRKILNIIFSEISTYKTEKSELLSCYINMGIEIYEKIEKDFENSDLEDDFILEISLSNCNSIKNLIHILYKTKSKKLGEYFTMVFKNNIINNYEKVPEILNILLNFLLNENDIKIRKKVMINSLKYIVMNGDIRMILSILIILAVIVEKFGNEILYDNFAIQVLSRHYYKPIQYLFCKIMNTERIEIFDPYDEFSLKNTENIIFSINKVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX72</accession>
    <name>A0A4V2JX72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1604p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001604">
        <property type="protein sequence ID" value="TBU10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX72"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1604p0020"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="275" mass="31853" checksum="5E243D446165B65C" modified="2019-07-31" version="1">MTTLRKEYRIVLPVTLSEYNIAQLYTVAEMSKSESTGDTSIEILENIDFDHEIYGKCRKTIKIMNLNSKVPSVIRKVLPSKALSLEEVAYNFFPKCVTTYTNKAFSSSSFKVTVESLHIDGNIYKENIFNKSIGEWKETKVEYIDISKTIVDSKYDPTVFRSEKKGIGPLVIQSRDGKDKSKNKEYKDWIEECVDKNIPLMTCYKYVTVEINYFGFGWLTKEVDRNIQKIFIGAHQKLFCDMDNWCDLTLEDIRQIEVTTKEELKKIVSENVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXI3</accession>
    <name>A0A4V2JXI3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0979p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000979">
        <property type="protein sequence ID" value="TBU11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXI3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXI3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0979p0020"/>
    <dbReference type="OrthoDB" id="2194085at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12725:SF117">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="671" mass="79026" checksum="48B97D4F3BB4A652" modified="2019-07-31" version="1">MTIPTRKKLKDITNISTKNKKSNEIEKCIPVTDEEIEYLDVISDTSSYTLYDDYTVNIISFPIFLYFWQIFLAADKNGVKILSYDEIRNEMYNNPLVYCVSIMCLNTFRKQNLLSKIIEEDLELPYPSIYDKIMSDTVFIKYNIKYLLRYEKDILKLFKFLKPKEATVWFVMFRSRLLNIIFCFFKDYLKDYSDKFNNHPFFRNMLKRQVSKNLDLNLANFDKFLEEKREIEIKMLQFDLNAYFERENVNYYLDKSLIGSENDINKVVDLEVDRENFDLTENPTNSGNKSVKDIHLIAGKKTENSKPKAQYPSPISDSKAISDSKEMNKVEYKSDVRIAKSIVASDNLPKIQSEKYKGTYKKDTKDRLKLYLQIFFENLLSNPHNPSRETEFSCYKQSNLYKRHKEMCENGTLESSDFIFSFFYKILFLKFETQWKDLLSLISTESNAGIQNILAYLDDYIPSSDFQMGVSNETLFISIQESTIPKMYLDEIVLVFDIDDTLFPTTSYGDKYPDLGTPEFYESQNNIFADPKEENPKKGINDQEIKTKLLVTQHLEYKTELKIFLEKLPFKKICFTNAEKIHAEWALKTLDILDCFICIVHREKLHEYIFLKPNPHAYFAIEQLLETKASNIYFYDDIDQNVQAAKNRGWNSFLVRDSLIDVLETSLSNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXJ2</accession>
    <name>A0A4V2JXJ2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0934p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000934">
        <property type="protein sequence ID" value="TBU12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXJ2"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXJ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0934p0010"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="233" mass="25843" checksum="6D7CFD5A15445698" modified="2019-07-31" version="1" fragment="single">DTLISSGSGLNSYTLSKTQMKSSLRGPERALIHGFNLISAFCDRSNITKTVMDRAKFIFKTVEEKKILKGKNTESVVAACIYIACRQENCARTFKEVSVLTAVPKKEVGRSYKLIFPHVDKMAVVSTEDIVARFCSDLNLGIELQKVAVKISRGAQQSGCIAGKSPDSVAAAVIYMVTHLFSNQRKVQKDIQHVTNVTDVTIKNTYKELLPYKYEIIPEGLVSKYQIDSLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXT4</accession>
    <name>A0A4V2JXT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0542p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000542">
        <property type="protein sequence ID" value="TBU13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0542p0030"/>
    <dbReference type="OrthoDB" id="2186354at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031513">
        <property type="entry name" value="MICSWaP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17018">
        <property type="entry name" value="MICSWaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020543166" evidence="1">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="26849" checksum="474A9EC84A51C4CB" modified="2019-07-31" version="1">MFKNIKFIWTILILQIWLNIMKIRGGKYGDITNPLNSNLSTKLVEVKIYVSPIAKNAYSVRGKSFEDMVYFVIGELERSVNSYLVKLDHPFVIKWKPLFQTEIPPGIDPDKCDVDLVSIGSILNILNMDDSMTSSILILSCSASSYNDAMIVAGLLTPYISHMLSTQCSVRTVLFFEAEEAKFISVMATGLVKAAAVGVLNPLMFEEIIDGDQGVRYEIRVSNDALEQLKNNRCFFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY16</accession>
    <name>A0A4V2JY16_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mad3/BUB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0323p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000323">
        <property type="protein sequence ID" value="TBU14455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY16"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0323p0050"/>
    <dbReference type="OrthoDB" id="2192347at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031522">
        <property type="entry name" value="Mad3_Bub1_I_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17014">
        <property type="entry name" value="Mad3_BUB1_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU14455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="478" mass="58313" checksum="EC4CB3D1AEDB23D2" modified="2019-07-31" version="1">MDIFAEIKDNEIEETLKKNLHIEFYKNNPSYIKLWQRYYEIKKDPKILFFMMHFGISKDYHWIYIELANHFKKLKYFELSYYVLSEAKRKNVFDAFEIEKEINNYSFDTKRFSDTEMKRILYPKRIYFWDTEWSINEILYCNLDNCFYKKNGEISFVSFEENRYLNGWWQKSENDLNFLEIKKFESEIENSYKYEEKDEKNFNKLRIETTDFENTKEELILKSKAVENQSNKNNSGVEQLNDSGKINKFLSEDEININNLIFQIKKRINNQKFIIFCLTETNNLEQSTEIKNYILEEIDEKYLKNIFKFTNNIFPTDLQSIVIAEKYFIKYPFSYETSVSEILNCYQEKKNVNEYIIGFYWVQILKLLIELKEQNLAIKELSLSDIMIENDLFSFKICNFKVENTCFENKNDFYENYKFFEDLNSFGDLKIFQFLNEYKNYDYLEFSIKIENILNNCDIKDILNEQLIFFYESINNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB3</accession>
    <name>A0A4V2JYB3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0069p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="142" mass="16452" checksum="9E3E1555AA2BD7F8" modified="2019-07-31" version="1" fragment="single">KYDLLANELGLIYKCSVEIIPYVMTWDGIVIKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRAEMHEEPTPPLKEEKREKYGGITLEEPTNNINKDSELEEETAVIKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC0</accession>
    <name>A0A4V2JYC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0056p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000056">
        <property type="protein sequence ID" value="TBU20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC0"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0056p0010"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="486"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="746" mass="85163" checksum="EF60DDEBFCD9263C" modified="2019-07-31" version="1">MDVGGVSNKSSNNSIDGYNSKGYKDSNKDSNNTNNTHIPNNTTAVAYFKNSIDILFKKIRGTHIHYIRCIKPGVRGFDSLYVIKQLKACGVLETIEMCKNTYPQDMYIEEFIERYSMLACGENNDMLERDRGVNDNSTNYKGDNDKGSNYKGDNDNSTNYKGDNDKGSNYKGDNDNSTNYKGDNDKGSNYKGDNDNSTNYKGDNDKGSNYKGDNDNSTNYKGDNDKGSNYKGDNRDDNKGIDTCKYNGDTVMDNGTCKDRGDRVMNTYNSKGHKESNNESYNNNMYYRNIKYKNAALNAYSKDCKITDKTYNDINYIYNSVKENYKDNNFKGENKGKNLKGNACNINNPLNNKIGISDINTPLNNDIRVSDINTPLNNDIRVSNINIPLNNSKNHGNIKTPLVNNVNIPITNTPLNVHMKVPISNTPLVTNIRKNNFKENQRGIPVSVDIKNPCDLNITANLNALQGKVPQQEYDNTIYYIDNMSLKVIRQIKRGGSSVVYQVLCNKEIFALKEIKITDKNDSLSKEYKNEIFLLQKFKKSNEIIKLINYKITDTNILILLEYGETDLSDVIRNTKKLSINFIRYIWEQMLLIVEKVHDSRIVHRDIKPANFVFVKGHLKLIDFGISKIIRPETTTVFSENAAGTFYYLAPEVLNNRDKKIKRSADIWSLGCILYEMVYGNPPLYNEKHVTDILCRLNDSSLQFEYKFINESYESVIDVIKGCLVYQPEKRKSLKDLIDMRFLKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYC1</accession>
    <name>A0A4V2JYC1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0309p0010</name>
        <name evidence="2" type="ORF">CWI38_0052p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000309">
        <property type="protein sequence ID" value="TBU03348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYC1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0309p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU03348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="417" mass="49974" checksum="2C462890C014AC73" modified="2019-07-31" version="1">MTNQSSSTAEFKDLFNLNNSLNTNSLSEFRIALHQYLPLLQKNTSRDFKIAAFDRLISCFFTKQLFLKKIIYSTLKKCHKFLKNHVDAILYKKEIILVLRSTDEEVKNLLLKIIILFSGTLYDDNELLYEIEKLSDNTLGLKCLGKFLSHSKEWIHEYLKTLDVKKRLKLIKYVEIYYSRYIFNMGLVQNDLRLAYFCAKKDLTCLIEFIIISINTIKQLSKDIPSDENKFIILSNLDFDNLNTDLNISKIVFDLNLVSKNILFKYLLKICIHFPVFKNKILKLLNFTSLNELIYNRTEDKRILHFKETIKLYEKFKIFNPQICRKPIKKVNLYDNLNFYDKWLLARYFIDRKYFKNAIIILNELKSINEMKSQYKIYFNFLYKFYKNEDISKIIPIIKFYRLDYFPLVGKILSRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVK0</accession>
    <name>A0A4V6MVK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2038p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002038">
        <property type="protein sequence ID" value="TBU10082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2038p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="126" mass="14235" checksum="A69FB8D62B9CC99A" modified="2019-07-31" version="1" fragment="single">GILKPKTCVEKENSHIHNEENDIPKKNYNSILKNQKQIQKTVKIEEITINNNEIADKEKKFSSRPNEKISTVPLLTVHDLNSSNVNTLKKIQAARNRGDITSMSTTEILAFNIVDGIFDGVSFLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZ77</accession>
    <name>A0A4Q9KZ77_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1233p0010</name>
        <name evidence="8" type="ORF">CWI38_1059p0020</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001233">
        <property type="protein sequence ID" value="TBT99740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001059">
        <property type="protein sequence ID" value="TBU11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZ77"/>
    <dbReference type="STRING" id="1176355.A0A4Q9KZ77"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1233p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1059p0020"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT99740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="169" mass="19536" checksum="C57ECCFA42104C46" modified="2019-07-31" version="1">MDINSIYAFSAKDKKGRTIKFKDFHGKVLVIVNVASMCGLAAKTYQNLADILERYYEDGLRILLFPCIQFLNKDTANLVKIGEQVNEYSERFILFNKIDISGKNTHDLYKYLIEKSPVWFKGVALSNFTKFLVDKDGKILHRYAANEYIKVDDIRLMEALSQTQKYNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L351</accession>
    <name>A0A4Q9L351_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sel1 repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0612p0010</name>
        <name evidence="2" type="ORF">CWI38_0173p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000612">
        <property type="protein sequence ID" value="TBU01858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000173">
        <property type="protein sequence ID" value="TBU19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L351"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L351"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0612p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0173p0010"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU01858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="66336" checksum="B3360E006B2827B2" modified="2019-07-31" version="1">MFDFLRKKSYTLSSVERLILSNSNDCQVVGFCNLAKQEYTPHVCALKGFCYEFGVGTTPDPNLAETHYIRAANDYHPLALIRLIFLRRFGRPNIRIDRREANHYMSILNTLKEPLLFLEKATTLNNPHALYVLGTCFHDALGTVKDPSRAVVLYQQAALQDHPPSISILAFCYLEGFGVVKDEDKAYELYTRAASFNDSVALYNLGYLYEEGRGVQKDCSKAFLLYKQSADLGNPFGMNSLAFCYEEGIGCTKDEGKAFSLYKKSAEQGYPWAQSNLAYCYQRGIGTKVDYTRSCHWYKRAAHQNLSRAQHNLGHCYQQGLGVKKDEGLAVIWYKKAAALGNVYAYHSLGNCFANGSGVKKNEEDAVKYYTLAAKDNFVPSLISLSFCYRMGTGISRNAELCFENMKKAAHLGNSYAQNCLGFFYEEGFGCPKNIEDALLWYQKSADQNNAWAQTNLGNIYFEGVSVRMDREKAVSLFQQAIQQEHTRALNKMGYCYEEGIVVNKNPNKAFSCYFKASLRGYSRSHYNVGRCYENGIGVFKDIDTSLVYFYRGSFCGDFRAKERMKKVLVSFIRYENREYSRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LA96</accession>
    <name>A0A4Q9LA96_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0100p0030</name>
        <name evidence="2" type="ORF">CWI38_0598p0010</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000100">
        <property type="protein sequence ID" value="TBU04689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000598">
        <property type="protein sequence ID" value="TBU12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LA96"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0100p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0598p0010"/>
    <dbReference type="OrthoDB" id="2195425at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="110" mass="13149" checksum="B4F17C5F13D2D65E" modified="2019-07-31" version="1">MLYVGGLPKIVFKTQKTKTKKEFKCCMTKEFCVLLYSDNTCYVDNQMDKVCFVLPIHLPSFIHKYDKKMNLPDSINKFFVFKSKEDKEMFSKYCQDFNDLKIRKIGFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LAC9</accession>
    <name>A0A4Q9LAC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0108p0010</name>
        <name evidence="2" type="ORF">CWI38_0263p0030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000108">
        <property type="protein sequence ID" value="TBU04634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000263">
        <property type="protein sequence ID" value="TBU17924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LAC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0108p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0263p0030"/>
    <dbReference type="OrthoDB" id="2193957at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="454" mass="54498" checksum="45361FFD774BD03D" modified="2019-07-31" version="1">MKHNDFEKKEKGSKLINIILSYTKRHTSIYKKFLKSCLEINEYKDIKINLNLIYESLLYEQKSKIDYKCLDYFLINNIPTILIKILESSNEYKKEIISFFEKIMIIFPDKAKIHPNIFQVINYLFIKKETHFLPLALIVCELILENSNFVEYYLQDECLIDIIFNNIFNVSIFGEYSRTSFTYLLSVETDKVINILFGKNYISKYILNLNEIFRNLPMKSDSEDSISHYLTVFSLLNILIKRLEKIDSEKIKEVIKNIEFLVYKEPKTLFMYWKEIINHTNSLQIIEKVIHSTVESNYIISYLNSPDKEIVEKTVEYILFLLYSHPMYVMPYFIMNGTFDWNSKYIYEELYIFYNQDCVSKYKLEFKEIKRKINSRFLIDRNKSIPNFDIKKNYFNELLICKGYRSCARLLVIIFLFSEETLLTNFDKIIDFGKRLKKEELISFYNNLNAILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCR8</accession>
    <name>A0A4Q9LCR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2721p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002721">
        <property type="protein sequence ID" value="TBU05709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCR8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LCR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2721p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU05709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="218" mass="25102" checksum="26AC779DD2F6B8F8" modified="2019-07-31" version="1" fragment="single">MIIKWHKRILKVENRNFKFEKKVKKAEFSNGRVIVVFKNEIAVIEENITILPFYKYKSIIITPKHIFLQSESNQIKEITTNIYSYKDISYEPDMYLCGYTETFFIYTPSSTEASNYIFFIKENSKRIFSIQKKIGKKIILKEENNSSNPNLSSNPNLSPNPNLSSNPNLSHNQNLSHNPNLSHNPNLSHNPNLSSNPNLSSNPNLSSNPNLSHNQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDJ5</accession>
    <name>A0A4Q9LDJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative subunit Rpb7 of DNA-directed RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_2866p0010</name>
        <name evidence="8" type="ORF">CWI38_2676p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002866">
        <property type="protein sequence ID" value="TBT96628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002676">
        <property type="protein sequence ID" value="TBU05934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDJ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LDJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2866p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2676p0010"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT96628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU05934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="160" mass="17475" checksum="FFFA07C6479E04E6" modified="2019-07-31" version="1">MFFVSNLKHIIHLEPEKLGPECMDILRKTLTSSVEGTCSGEYGYIISVLSIDKIGSGRITNNGYAVFSVHYQALVLKPLKGEIIDASIVETNDMGIFAGVGPLTIFISNYQIPKMLLKGSEGGGLEKNSNIRLKIIGTKVEATRIYAIGTINEYYLGLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LDY9</accession>
    <name>A0A4Q9LDY9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2646p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002646">
        <property type="protein sequence ID" value="TBU06084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LDY9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2646p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020606349" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="88" mass="9976" checksum="BE2E1F5416E5FC9B" modified="2019-07-31" version="1">MLCFLIFLLFTNIFGKVAIPYSVEEVNTIDEDSSNTGKEIVQVINIETGAVLNNPESKQAVHVKRSPHCPGIFPRHIISSYGFHRWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEN7</accession>
    <name>A0A4Q9LEN7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0974p0020</name>
        <name evidence="6" type="ORF">CWI38_1067p0010</name>
        <name evidence="5" type="ORF">CWI38_1782p0010</name>
        <name evidence="4" type="ORF">CWI38_2299p0010</name>
        <name evidence="3" type="ORF">CWI38_2642p0010</name>
        <name evidence="2" type="ORF">CWI38_2649p0010</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002649">
        <property type="protein sequence ID" value="TBU06066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002642">
        <property type="protein sequence ID" value="TBU06106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002299">
        <property type="protein sequence ID" value="TBU08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001782">
        <property type="protein sequence ID" value="TBU10408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001067">
        <property type="protein sequence ID" value="TBU11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000974">
        <property type="protein sequence ID" value="TBU11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEN7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0974p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1067p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1782p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2299p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2642p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2649p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU10408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15551" checksum="F25C5C097B816D26" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LF72</accession>
    <name>A0A4Q9LF72_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2531p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002531">
        <property type="protein sequence ID" value="TBU06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LF72"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2531p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18321" checksum="7B341EC34D561823" modified="2019-07-31" version="1" fragment="single">MIISTVFCTLESTVEDDIQHAQNQSRRCNFEVNRESQDMKVKIGDQHASNSGHGPKKAQYFGDQDGCDLFTSEPSTSQFEPSPRKQKRRLTNEKNSLRLLENPQRNITLKMKLENIEAVKNNFLKQLLDSKILKFTSENMNLPENRRYNPTVGYPIATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFL3</accession>
    <name>A0A4Q9LFL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ndc80-like chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2514p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002514">
        <property type="protein sequence ID" value="TBU06744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFL3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2514p0030"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="247" mass="29398" checksum="207B940DA9D875EB" modified="2019-07-31" version="1" fragment="single">EFENIYVSKVDEGEKLLFDLKGIRNQPLPFLISKEKEREEKMDLKFNSCEQKNDLFVEKGNSPQKSVENSKYLDFDFRICEEYKIIGNTDEYVDTIDKEVIKERDEFTKYEISNKELLERKSNDESACKEMERNIKIMEEKLYSVGKIYLEKKELSDNEQQKSRKELEKIESDLLRLQLDSNNSLLISEQTLQRAKINVDRIIQTSKSEKDEVEKLLANFNENLQSYYKIIRSYMKELENLVPKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGK6</accession>
    <name>A0A4Q9LGK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1880p0010</name>
        <name evidence="3" type="ORF">CWI38_2495p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001880">
        <property type="protein sequence ID" value="TBT98150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002495">
        <property type="protein sequence ID" value="TBU06856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1880p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2495p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="171" mass="20449" checksum="4D476D359B4216B8" modified="2019-07-31" version="1">MDFISNFFKKKKTQNIDTQFSLKNIRENISRLMVENDKITEDLKKMNNMKCQGKDIMMYKVKLFKNNMQSLERLKHLENMYLEIELTKLQTETYQALEICAKDSKKVYENIDFDQIEETMDVMEQMKEEMCDVNSILYDDCNYVNDYDLKKEIDGIISNESTIHDDKENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIA6</accession>
    <name>A0A4Q9LIA6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2477p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002477">
        <property type="protein sequence ID" value="TBU06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2477p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="797" mass="90009" checksum="0EAABDB22EEFEFDF" modified="2019-07-31" version="1" fragment="single">DKQHPVNYTTDKQHPVNYTTDKQHPVNYTTDKQHPVNYTTHKQHPVNNSTYNQDPINNTLLFTNLRLNIITPLISILIKVKEIKNKNIKKILIKTNNTLLNISKISLINNTITNIRIIKDESTDKDIFYILQFLKELEIIPFTSKSSEEEVFIIRNVKIISYFSLSLYSKVIFKSKNIYILFKKDSLRIEIPISIGVNDSGLEGFSDSSRLEGVNDSGIEGVSDKGSGLEGVNLSNYNYKGVNISTNKQHPFNTNNNTTYHPFNTNNTTQHPFNTTINTLNVSLVILKDTNGLIITPVITGSIDNEFYRILTRNILEIIEITLNIIDCILIKGEKTTFNFNILPLVCVRLYCIIGNSVIELGVLDSSIEIKGVSGNSFIKEEGGVNDTGVDKDRGNGLEGVKDKDSNYKEEWGVNDKDSNIKGVRDKSTNIKGVSDKSNKDSYKDSNKGSYKNNKELLDALLKGINNNTNNYNNNTTNNTSNTTPLDVISTDFIYQQFIENYPLIDILTPFLLLTINIKEISLKPIKYYCNIKGVSDYKDIKGVNDKSNILENIKGVNDKDNILENLKGVNDKDIEEGLNYKDIRGVSDKYNQEEGVSDRDIDEGVNDKSNDYKDNQEEGVSDRDIDEGVNYKSNDYKYNQEEGVNDRDIKGVNNKSNEHNPFILITNSTIIILKGTLGINTHISIRKVNTLQSLTILLLIKQSFITPDFSYGIPTLLTPFNIYLKIYNIEYTTVEYDSVVKGVNNSTYNYNPVNNSSSKQQGVNNSTYNYNPVNNSSSKQQGVNNSTYNYNPVNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIB2</accession>
    <name>A0A4Q9LIB2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2334p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002334">
        <property type="protein sequence ID" value="TBU07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIB2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LIB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2334p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="40101" checksum="7481567DDD1A1600" modified="2019-07-31" version="1" fragment="single">VKKNKYLNSLKMNSSCLNQKVFKSMICSDLLIDLSLRAVDFTEIKVDKDCFDRKKTFQFLDLSECKFNDEFLDYFLTDLKAKKLNLEYFPDFQHLIKILDQESLHLSTEFLSLSGNSLYVDLYISVSRFKVLKRLKLSHMNYMICNDFHPKFAFKHQLNAIDLSKNRLNKDSMIFLHQFNNLKELNLSNCNLETGYMEILFTEHLSNSLVELNISGNSFVSSDFFKIVYLKNLIRLTVSFDNQVFLNLEDKYDIWKFKKLRTLILVQTNIEDLLYKSVMTIKDIKIIEFQNCKFEDDVLSKNNNLNPISVENIILINTKISNDDINVLRKFKINGINVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJ21</accession>
    <name>A0A4Q9LJ21_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2319p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002319">
        <property type="protein sequence ID" value="TBU08007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJ21"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2319p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="123" mass="13832" checksum="692CFC3C9958D9E4" modified="2019-07-31" version="1" fragment="single">MQNSGFDTLPSPNTPLPSSVEISACEPSYDMTNPFTIAILGGMASNCFFLQYRQGLKECQEMARQSFTGTQSEMGTEVISEDNLERHKFLSKIKEISEKEIGEVMVRTRKHPDKLVNKVLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJA6</accession>
    <name>A0A4Q9LJA6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_2281p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="PITK01002281">
        <property type="protein sequence ID" value="TBU08289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJA6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJA6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2281p0010"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="292"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="637"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="790"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU08289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="986" mass="109695" checksum="6A0CA92D21BC416F" modified="2019-07-31" version="1" fragment="single">NTSTNVQQGVNTSTNKQQGDNTTTNKQQGDNTTTNKQQGDNTTTNIQQGDNATTTPNITPNIHFLKSINGLKRFIARTKILTHLKNINLLKKEEPHTYTLPFCSRSNDIIEPILKKQWWLKCNNMAQKAIQAVTTNQIEIIPDECKNRWFKWLENIRDWCLSRQLVWGHRVPAYRVYVDNVRQGWVVGKDKDEAMKNYMSRYNRGDSSSGGSSSSGGSTSGGGSSSGGGSSWDNKDNNSNNKDGSIKDNNSNINKDIKHVKDSTNSDNSPDNNNHDSTNPDSTNIHTTIPNIPIPNDNNTHPNINLVQDDDVLDTWFSSGLWPFTVMGWPDNTKDYSYFYPTSVLETGSDILFFWVARMVMLGIELTNKIPFNKILLHGLIRDSHGKKMSKSVGNVIDPIDVIEGISIDKLVLRVSNSNMSDKEIKRGIEALRIDFPRGIGECGADALRFGLCCYCSGVKDVNLDVLRIEGYRKMCNKIWNAYKFMEMCVNDKDRLGSGLGCSRLDSNRLDSNRLGCSRLDSNRLDSSRLDSNRLGSGLDSNRLDSNRLDSNRLEGVSDKNKSNTTTTNTTNPNTTNTNNNNSSTTTTNNNNPNTTTTNPNTTTTNPNTNNITNTMYFIMNNSNILNSAIEYDLILQWIYEKRNICIEEYVKCITSYNFMGVCSSIHKYFIYDFCDVFIELCKVRKEREYVVVLVSVFYDILKMFSTVMPFISEEIYQKMVGRYEEVKGKYIRGGDKEGDGGLDMVGGVNNRSSKEIVGGVSNKEIVGGVSNNSSKEGASNNSSKEGVMNNSSKEGASNSSSKEGASNNSSKEGASNNSSKEGASNSSSKEGVMNNTDTLHPVNNSTNTLHPVNDLPNKQHPFNTDISSLTNMVTDLTPISICVSDFPIRKGCYDLRFTSMVEVVKRIRSIVNSSGIRMCSVGVLCGENKWVEGYLWVISKLVKEVVRVESVDRIEGQYIDEVDGIRVCVNDVGESIERDISDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJC2</accession>
    <name>A0A4Q9LJC2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2279p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="PITK01002279">
        <property type="protein sequence ID" value="TBU08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJC2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJC2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2279p0020"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="17868" checksum="B2B4D3E7B1FBC071" modified="2019-07-31" version="1">MNVITTDNIKKNNTSYSLYSNNNYTLKPKTLQYIHTGVNISIPNNNFGLLTSTKYKIMGGVIDSDYRGEIVVMIYNIYDECICVSKGDEICRMYVVSICTPELVMGLDQQEGNKGLYFMGLDQQEGNKGLYVIVDELEEGVKGLDQQEGNKGLYFMVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKJ6</accession>
    <name>A0A4Q9LKJ6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA replication licensing factor Mcm3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2219p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002219">
        <property type="protein sequence ID" value="TBU08799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKJ6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKJ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2219p0010"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM AAA-lid" evidence="3">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU08799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="290" mass="33232" checksum="871904ADBF3C6920" modified="2019-07-31" version="1" fragment="single">DRRDNKDDRRDNRRDNKQDGIIPLPVDVLTGYIQMCRRITPVMSDEGMEVLRDEYCMLRGLDNGKSITATTRQLESMIRLSEAHARMRMSKVVEGKDVREVVSIIKESMLLYAIDPISGKIDMDVVISGRSRSWRESVDRVKKEILGVVKDRCCIGEVVRVLGGEERLVVEGVRELDNEEVLFYDEKSGELDSKEVLFYDEKSEERVLDNEEIKDSVIGRSVNLMVLIQYDEDSDSLFEGISDLNRDNYDLNLGVALSMSLGEELKVKNPSAVQKDVDEYLEKLLNNKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LKM3</accession>
    <name>A0A4Q9LKM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pumilio RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_2217p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002217">
        <property type="protein sequence ID" value="TBU08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LKM3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LKM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2217p0010"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="222"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="558" mass="64633" checksum="B5D3848C9D417852" modified="2019-07-31" version="1">MSFDKRKSFINKFKQKNDNKNGENDTDFENNVFRVTNRLYNESFNTRCTSAPPVEKMLVEDEHINLEELNNEINYAAYYRRNSRNEPRLPPPNFYMLGQSSFPYGDNSNASLVRGAFSSTSSKAPLLSETVNTISIRKTHAPSLLDRIDEDHPYSEKSSEYKGPSRTTTPIGNAMGFESPTPILASIFSDETYKAPLQAQEDSLLKPLYLGFKEDILKFGIKTSSTQDSPFNKNTEFLYNFDQDFLAKTFCIDLSRDQEGSRFIQKRLEEGTEIERIWFLSQIEEAVLELTTDLFGNYVIQKLFDLCVNRQRQEILQRLKGRIVSLSLHMYGCRVIQKVLDMISPLDDIVEELKGNILGLIEDQNGNHVVQKCVEKVENRDFVIKEFEQHACKLAKHRYGCRVIQRLFEFSINNECSKMINLILENTEDLIENQYGNYVIQHLIEHGRNGERGIIMERVINNSYELSTHKFASNVIEKCIVEGNDLDRIKFLEKFVVKKNDKPLLVTMCMDKFANYVVQRLLEVLDVNSKEKFVECVKPYSVELKRSVYAKHITSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLB6</accession>
    <name>A0A4Q9LLB6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2192p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002192">
        <property type="protein sequence ID" value="TBU09034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLB6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2192p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="831" mass="94374" checksum="FD2BDC50F624B029" modified="2019-07-31" version="1" fragment="single">MNRSYIKNLKIYLLSHTNPLTVLSLCIEKNFHSKKVYKIILKKILTNRNNEQKPYKPNENTSNRISNINENISNSLSNTIHNTLSTNTPNDIHNTIPTNISTDIHSNTPLVNTLLIVSKNIENPLFFKKFPLQYTLTYILTNIEITPYIYTYLHPLLPYIQLSYLSPLDSSFNSFISLHFYNFYIFTNLILHNPYLRVNYSIDSYNPVNNSTNTYNPVNYNTDSYNPVNYNTDSYNPVNDSTHTYNPVNYNTDSYNPVNYNTHSYNPVNYNTHTYNPVNDSTHTYNPVNNSTNTYNPVNNSTNTYNPVNYNTDSYNPVNNNTIINTPLNTNLDINTPLNINTIINTPLPPLPLITTTSLPLITHLLTKLVITFKKDIENSNNSYNKEILKYLHTNTTLPYRNILLSIICSTYTVTQEEVNSYILYCDLYFSKDSFFKEFNNKPLHLNICGNKNDGGEKTLNNSNNSLNNSNNSLNSNKSMISSKSNNSYISNISNNSNISNNSNNTLINSNCDNSNNSSSDNSNNGNPTVTLNSCINNTTIPFSPLLPYINPLQIVNPNLLNYTPLFICYSISYSYTYCIKCNTPLNNLILFFNTHNTYYKNKIGGDIGRGIVGEGVINSGSKGGVINRDIIGGVNDNGSRLKGVIDSSSKQQGVNDKGSRLKGISKSSRLKGIIDNIDKQHPVNHIPHKQHPLYNNTDKQHPLNISTDINTPYILHTILHTTITPVTLTKILQSTYKYNTLLNIYKNIKINIEIEQLIIGVLKYIDSNYNINMFITTLRIVNNLPFTDKIAFSSFVVIYNGISKYGLFKEEDILEGINDSSDWYRDIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNV8</accession>
    <name>A0A4Q9LNV8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1998p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001998">
        <property type="protein sequence ID" value="TBU10133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNV8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1998p0010"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="102" mass="11781" checksum="833D8C39378B935C" modified="2019-07-31" version="1">MKTNITLATVLKKIILFKKLQNDGYTISDGIKYGVDILVYTGNIDEYHAKYAILFFDEQCIKDIVSVQRICSSVGKILVLVDESFNFYEVERFNAQENKEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNW7</accession>
    <name>A0A4Q9LNW7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polar tube protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1489p0020</name>
        <name evidence="3" type="ORF">CWI38_1990p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001489">
        <property type="protein sequence ID" value="TBT99045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001990">
        <property type="protein sequence ID" value="TBU10143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNW7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1489p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1990p0020"/>
    <dbReference type="OrthoDB" id="2191141at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031507">
        <property type="entry name" value="PTP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17022">
        <property type="entry name" value="PTP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="278" mass="30189" checksum="78656754FC9CB66E" modified="2019-07-31" version="1">MVITSGTTGGLGQQTTGSSKNSNAVLGLQQNRMLNTALNQLTAQQMSEPMAKAFIPGYNGTNLYCDPRGVEGNWQLVSQKLKQECIAKSQERSDRAIKLAKQLTQPKPQDCTVRISKGSMACHARKVLKDVITSPYYTLNMYGNVVEVMVGDEVVMMAVAENVYYDITHKSHERPRALKRPTASLEFNQLGGLLSQKGELPKPKKEDPCAACLEYLSKQTTAIEGQSENCGGCDSMMEITSVRSDSFRNVTKPNGQSSSTKPSKPAENGNEEGNGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNZ0</accession>
    <name>A0A4Q9LNZ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1974p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001974">
        <property type="protein sequence ID" value="TBU10163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNZ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1974p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="227" mass="26688" checksum="C3FC368FC30F7F28" modified="2019-07-31" version="1">MESVGTIKKIKEKKKNNNKWNEIRTSYACVPDNEYNLNSFYTPQFDDDSLHELTPDEIEMIKRWKDDLLPIVDKNGSLYLTYTNTSVNDKIISENNHSKPILPLSAFHTHLSQNEKNNDKELILSKKWEISSVDNSKSDREPVISIVNQKGKIIGIKNTVYNLLILTLLTVLIFSWYQNIQSVHNYVYTAFKYDSYSRFAHLSIFVQKIIYYIQYIINNLKKYALYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPG5</accession>
    <name>A0A4Q9LPG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2033p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002033">
        <property type="protein sequence ID" value="TBU10087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2033p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="535" mass="63132" checksum="6FC7CBBB445E6984" modified="2019-07-31" version="1">MISYTNCISNIDVSWITMHLMGRIVYGAMKKGSELTKEWEEDLNNSLNEALFRKCMSNFVNPSRQSKTKNFRFITTNSMQDLFDFYFIVEPGFRLVKESIFDTINFLNADEFIEDVNKQTKEYLLKEKIKRGEFVDKVISKFSSLVIEKLKCLLENKFSKAKQCDDKNSMILNDGYKVLAQEMNKLCDKFKDKNEKELAKAVEDNTKEAIVLNILEVIKFKFFLLDCGEIFISKFYQLLYIKSNKDLYFKFFGKTKNECIAEEKEKNNVYKRLQSMRQELKYNDNLDNIFVRFSNEDASSQYIQIFSLFCSRTAEIRTCLEKGKSNPTFFFSTILSDEFKMFQPLFLFSESILYFGIGFSQKIKSNFIDYAGIFNESQVVHISFIDLKPFLPEFLLNYSELLINSENKHNLCEIIRKEYKSISDNTEEIIKKTSSDGNIRVGFLHEIYKVYLKSKFFECKLNIYAFDISLDSFREIYSKFLKDLKGKTKIFLIDEEEMEKCRDFFLKCILFKIKSMTDTFNLENLLSIEVTTIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ74</accession>
    <name>A0A4Q9LQ74_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1714p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001714">
        <property type="protein sequence ID" value="TBU10504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ74"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1714p0010"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="216"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1456" mass="164285" checksum="C538BE3E5EB7F245" modified="2019-07-31" version="1" fragment="single">MRGESAYLSVTAARSRNILVVAAMNKYGMIYHKIHERAVNGEDFKLFLKEIHESCQRQRILTPIFVMDNARIHHYRGLNDDEEIASYRIKYLPPYCSFLYPIENVFSVWKNKVIRGGARTEPHLKEEFDNKLEANSSSNSSSNTSSNISSNSNNPTTISSINPTKQQNTISLFHTHSFNRFDTDFGLFTPTFPINITLTIYLLKTPYNSFKYTSFTGIKNLGGTCYINTLLQTLFHIPEYRNMILSLGYSNSNNMLDGSSSNNNSNMLDGSSRDKIYDKNKDNLYDNNKDKLNNNKDTINNTTTPLLYLQHLFYQLLTHTDIQIKPFIIKSNIFTDTNTHQDIHEYSKIFFDFLEKEYKGSGGCGSNGSSNSSSSSNNIRDIRDIRDTNNNPNTTTDNNNPNTTNNNNPNTTNNTTTTNNNNPSNNNPNTTNTPTNNNNTPSTNPNSIIDGLLLNYIHCIDCNCKSTNKEHFQDLQVDIRDYNNNNISNTLNNSLKILFNKEILEGNNMYKCNIHGHVRAIKGMCLYKGPSVLFILIKRFNIDYETGEGYKINDYFEYPEVLEMVEGGGVGVGGGVGGLDGLDGSNNSMLDGSNKDIRDTRDNIRDTRDNTTDNIRDNNTTTLTYNLHSVVVHSGTAHDGHYTAIINIKGNYYKFNDTIVTPVCKEEALECNYGGVHPYKNKVRVSNAYMLVYRRVGDNGLDNFIDNSSIRDIGSSNRDIRDKDIDTNPNPNKCINTNPNPNKCINTNPNPTINTNPTTITYPTTTPTIPLPIKYPIPTTTLHPLLLSTFKKEFKDKIIYIFFKPINIGIKGNIIIIRLKMEDDYREKVREIYGVYRKYLYMFEVSNSDSVVGGVGMYNDIDNNLVGMDNNIVGMDNNIVNTNTLGNSNIGNINNINIGNSNIDNNIDKSNINNIDNINIGNNINNVNNKHTNINNIDNTTTYPTLSYTTTVKDKGIYFAYLSDNEYNFNNNKDYLLFTKKYKEIPLCKYNNKGVLIDCEVKVIRRDMIGGVNNSSKEEGVNNRDILEGVNNSSKEEGVKDKSSSYKGVSKSSKEEGVNNVSNVQQGVNSSSNIQQGVNNVSNVQQGVNNSTTVQQGVNNVSNVQQGVNNCSNIQQGVNNSSKEDGVNNNNIEQHPVNNNNIEQHPVNNSTTVQHPFTNTNIFIEHQSISYVIYIYGDKEKIKKYLEYYRRGKEVELEYIDSNIDSNDNSNIGSIEKYICYGRKGKANIKIKYFIRDRDSSVRDSDRDSDKYSSISDRDNSKYIKTKDKETNEYNEYKDKETNEYNNIYNKETNEYNNIYNKYNTLNDLKMYLCCDKVRLLDGKVIIPKGYWLIKVFINNEEGYNINRVRHKHIMCVKRGVKVKEFIESVKRVGIECGVIRSIMGSDKGSKDMLEGVSDIGKEEGVSNSGSSYKGVSNSGSSYKGVSDSSKEEGVSNSGSSYKGVSNSGSSYKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQG5</accession>
    <name>A0A4Q9LQG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2132p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002132">
        <property type="protein sequence ID" value="TBU09630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2132p0010"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15500" checksum="A7F41D935DB31F0D" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEEKIVVKEVEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR26</accession>
    <name>A0A4Q9LR26_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1426p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001426">
        <property type="protein sequence ID" value="TBU11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1426p0010"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="143" mass="17406" checksum="6A288870AEA0128A" modified="2019-07-31" version="1" fragment="single">TVKMKDLVVCKRFDGQKVIFYEYEMYMDLLEATSESYKTQLESKKDKNNKIDNDKIVDEKVEKEMRNNNNRDDTDNAFIDKSINNSFEGYDYILIYKHIFEKYSNVFYEYEIINTFKYMHVLFEEEKGIYMLVLKSKKYNNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM1</accession>
    <name>A0A4Q9LRM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1394p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001394">
        <property type="protein sequence ID" value="TBU11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1394p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="93607" checksum="C5420980A0C902B8" modified="2019-07-31" version="1">MNVCAIFKRRKPSSQIFYIYNLIITLCIFLKFISSNKFVYWFERITNSEIKFYREAQQPNINLEGSDVIYRLVISYSSDEKPMELSDHVFTYENTNFISFEVLKSLFDSNTSKNQCGKIECNFELEYILRMTKDISALPDTVNYNHFESLLIVLKYLKAVADKNLSQLLQRFIMKICNSENFVDSTKADVRIEEVFCKNIFFQSELSVKKTMISAYLNILMLKHVFCDENLIILSNKNEIFDTSLFNKHIPYKNLLINDYKAFCILEYHFKSPKILDILKILLNEINIKSLIFYNFLNYRTTDINFGFLKYLTDIFKSLIVFKPLGVSQIIYFELNKVFDLNLEFFTLRKLFVDRDTLIFFFNKQTIKGLILDNITLDVDIDYFQKIFCLSEKLEYIEFKNIEMPFIWWIEFLQKSNIRKIILSFNSRFVTTNFIYEWCKIEFHPNVLYLEIAFCYFEICREFWDSLWYFKYLQTLKLFDYESNKKTELCVFRAIKNMKDLENLSINNDFLSNDFFIFLFKKQGIKILHLNNSYFKRQTLNLEITNNYKSLNEIILKNIYVSKNTLKEIFKLESLSKLSFQFCDLKSKKSTEYLVFMSKNIKKLYLMGSVVKVFEDLDIFAGLEYLEKLQILGRKIYSCSLSNINLLCNSTLKSISYRSGILNLNNLNRLKLLKVLEELDICECEFSECCFYQLGKDCMFLNSLKYLNLSFVRINLTDFAYLNNFKNLIFIELSYSGVPLIQLKFTRISSQKCHFFTKETCDEKNARNLSKRFMEDGIEGIYLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRM3</accession>
    <name>A0A4Q9LRM3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC1 serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0218p0040</name>
        <name evidence="3" type="ORF">CWI38_1340p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000218">
        <property type="protein sequence ID" value="TBU03877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001340">
        <property type="protein sequence ID" value="TBU11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRM3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRM3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0218p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1340p0010"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="135"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="469" mass="55471" checksum="4DE5D9853B3BB941" modified="2019-07-31" version="1">MFNIFSKVMSDFQYFLKPKNEILKTEIMLYTNNRMKKPSKIYILLRTTKTLSMMIPVILSYKTPLFKYFVNIFVKNNGYLLMKSGQWISTRPDIFSKDLIMILSELQYKAPFHSLKYSKRIIQEEIKNPEEILDFLQFEPIGSGCVAQVYKTKYKNKPVALKILHPNIKNILRNDFYMLEFALKFLKPILKLDYSSELRFFYTEIKQQLNLKKEHRNMEILRNNFSKNRNLIIPKPIFSTKNILVEEYIEAKPLFDVIKDNKVGCEIKSWLFSASLDFIAQMIFKDKFIHSDLHPGNIYVKDNNGTYQLVLFDYGLCKRLNKTSYKNLFDLSFELLISKNGKKAASLLLNRLEVNKYLSKDKNEFKSKINILLNDFIFKHKVRSKNVSSLTFNNFALKFLESIQKHNVRLDPTYSNLILSMVCFSGIFAGMYDKKTFVNSIRKNISSRLILEIYIKKLSNKLRYLSRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR8</accession>
    <name>A0A4Q9LRR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Gti1/Pac2-like cAMP-independent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0162p0010</name>
        <name evidence="2" type="ORF">CWI38_1923p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000162">
        <property type="protein sequence ID" value="TBU04257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001923">
        <property type="protein sequence ID" value="TBU10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0162p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1923p0010"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="457" mass="53792" checksum="7B782D99815DA241" modified="2019-07-31" version="1">MNSTIETFYGCLHTQSDCQKLILLCQYGHLGRIIRRLSSYERASIRCGSIFVYEESESNIFRWTDGRAWHPSRLRGCFIFYKEKGGKLLKKTLNMNIAGKKYHVVAYQNDEDDQKRICCQKYKTKISTFFNQYEHMFNNLKYASTEQENISNSNVSSINMPELFDFGKQDASFNEKINENSFLNSEESKNNSLNTLNEIKCSDLNIGNNNSINKNYVSSSLEPLSEKNEKICKMCDQKIFDKLKNPFTQKLNSNNLINDNFDSKNYKNVYKSYFREHGIPKEIPSSNYYQPSPHLRQNEHFKKNISFSPNQQNEMQHGNIPVPSYPYNNRSTTIPYNASNYKYFKNSPFSDPISRFYNPYIDMSHKNTLNENTMPHFIQKIPNNYFKIRKKQEMEFNNKNLVSYPYDITTENNIEYFNTRNTSNTPTNEETLKNEDLKNANDLNIQSNLENETFDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS12</accession>
    <name>A0A4Q9LS12_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1867p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001867">
        <property type="protein sequence ID" value="TBU10300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS12"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS12"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1867p0020"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="529" mass="59542" checksum="331DDBBFA1A26FA5" modified="2019-07-31" version="1">MFENKTVEARRKQREEQQVELRQQRREDLLNKKRSMVSKDTAPQIANLKEMKSKVLSNDPNIVFQGVFEFRTVLSVEKSPPIQAVIDSGLVPRFVELLSTSCNIYQDPSTDLTTNTRLESAWVLTNISSGTTEQTSHVVDCGAIPLLLEMINEPSSELIDQGIWALGNIAGDSEAMRDSIINSNATPTILSFISDLLHSKEHLKILRNATWLLSNLNRGRNPPPPLPHMKSCIPVISLLTTHTDPEVVTDSFWAASYVCDADISTTDLILSTEIPNRAILLLKNIINKLSNTDSTSSYNDNSLYKIAMHSISPVIRMLGNILTGTDEQTNYLLDMEILTIFKDLLILYQEPSKQSRLRKEICWSISNITAGTEKQVERVFESKIIPILIDILNYSELYVRIEACYAITNSLSYCNTRYEHLEILLENNFLESLKDLLMVVSNLVEVQVNILNGFKMALEGCRAKYKKYGNNPVANRMEEIGLVGVIEELQDSGDASVSDKAYNIIVEYFNVVILEVKRVLLGSSYISVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS34</accession>
    <name>A0A4Q9LS34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1826p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001826">
        <property type="protein sequence ID" value="TBU10355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1826p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="132" mass="15959" checksum="5AAE4A29D7659D58" modified="2019-07-31" version="1">MIVSNKVDIFKNTYTLKIIFTIGSILLIKNIKADMSIIFHFYDLQNQQECNLNCNKEEKMQFSNFIKQRYNCYEHEECIQCTRYIIKDPSELILNLDDNKSNENNEKKIYICTDVCKYEDFLYFFENIKWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS73</accession>
    <name>A0A4Q9LS73_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1794p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12 13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="PITK01001794">
        <property type="protein sequence ID" value="TBU10395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LS73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1794p0010"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1497" mass="166984" checksum="C91BDC4109AA100A" modified="2019-07-31" version="1" fragment="single">TIVYRHLLDNDYVLVNRQPTLHKPSIMSHRVKVLKYEKTLRMHYANCNSYNADFDGDEINIHLPQDVISQVEAQMLSCTDSNYTVWTNGSPIRGLVQDHVIVGTRLCMKGVFYSKREMEEYISEVRGGDIGVGGDIGMGGDIGVGDMIYGSSNKDKDKYKDKGYNDKGYNDKGYNDNNHTNNTTPNITPNNNTTNNITSLLLIPPAILRPVRLYTGKQLISCILLSLNIKITYKGKSKVPFNCTDKYTLIIKGYLLTGVIDKNQLGSVNKSFIHYCSVIYNKEICNELLSVFSRVFNRIMVSDGVSVGIKDIMLCNDFKRSDMIKVCRERGRIKGEGDYEGGGDYEGGGDYEGNDIDYEGGGDYEGNVLEGDMIKGVSEQDMLEGVSDSTSSYKGVSDKDSSYKGVSDLTCNLEGDNTTTNTLHPVNTTTNTLHPVNTTTNTLHPVNTTTNTLHPVNTTTNTLHPVNNTTNKQHPVNNTTNKQHPSTNTTPHTTTHIQNNTSKRLKPLSPINNPSESQIKTLMSECTTTMINDLLPSYLLTPFPYNTFYLIITSGAKGSIVNLSQISVLLGQQELEGKRVSNMISNKTLPCYSIKDMIEIESKGFIFDRFLTGIKENMYFFHCMAGREGLIDTAVKTSKSGYLQRCLVKHMEGVKVEYDMSVRQGKKVIQFIYGDDGIDCSKGSLIREYDMYKENCGYGDSNSNRDSTRDRDWDRDSNTISNSNPFSIYGRISTPIFNNNNTTPISTPISNNISTPLSNNISTPISMSSVINYFPPQLFIPSLKYFEDLKVYCDKNIGYNGDSNRDIGNRDSISNRDSISNRDSIRDSISNRDSIRDSISNRDIGNNNTLSNNNEIPYNNSLRNYNDIPYNNHNNTNTNTTNTNHNTSNTNTNHNTNNTNHNTNNNIHNIHNTTNTNILVSYILKKYISSLVVAGESVGVLAAQSVGEPSTQMTLNTFHLAGVGSKNVTLGIPRLREILMVASKKIQTPVISVRYYNISNVLLERVMSCVVLKECVDRISVSEIGNRISVNLEINGRYFMGGNSSGGECGGCIGDSSIGDSDNIDINIDNGMYNGIDNGIDNNIDNGINTNTNTINDNNTINTNNTINTNTNDITYTINNNTNSYVVTSSSIYKVVKGKYLKMVDKSIKNLYGVLNNYKGSCIKVRGGGSSEGEGEGEGEDSSSEEIDEEYIGKVEDSSEEDEGEGEGEGEDEGEGEGDRRKDKKKDKRKDKRKDRKKDRKKDKKDRKKDRNNKTTTKNNKNNKNNKTTTKNNHPNTNTNTMNIRFYCISNLETSFVGRIINLSFDLNFNKNIILFPILEDTLNKVIVRCVEGLRNPICDKNILNINGNDLYSLCSVVNINKNIKNYKNFLDIEKSYCNDVYGMYKILGVEGCRSVLVREIESVFDVYGIGVDNRHLGLISDYLLVDGVYSSFSRFGMEKSESILLKMSFESCYSVLRDASHRELGDCLEGPSGCLTAGLPVRNGTGCFELLYDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSN9</accession>
    <name>A0A4Q9LSN9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1671p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001671">
        <property type="protein sequence ID" value="TBU10575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSN9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1671p0010"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="457" mass="51772" checksum="D8735EC071F408B3" modified="2019-07-31" version="1">MSENPKINLKDIMSARFQNPKFVYDGKRMRNMAIRKAVDYSSAIIYHRNFTKNIPIQTTAHYDVSDHIIALKLPHHHVSSYNYSSYGTSEITNSSFAQENQMNETDQNSNQRTSMNTHSTAYDTTFTLNTKFAHASINKTRCPVNTLRWTPDGRRCISGTSTGEFTLWNGYSFNFETILQAHESAVRSMCWAPSAQFLVSGDSLGTVKYWHPSMNNIQIIQAHNESIRDICFAHSDSKFCTASDDGTIKIFDTKDCKEESSMSGHGWDVRVAQWHPYKSLIASGGKDNLIKLWDPRMHTEILTLHIHKNTVLALKWLTRNSSDSVCNYLLTGGKDQVIKMVDIRTFKEVCTYKGHRKEVTALCAHPTINNMFVSGGAEGTIYYWQSFKEEPVATTTEHEGTIWCIDYHPLGHIMASGSVDQSVRFWIRNRPGLGDGESVEVEDSEEGVNVQRIPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ0</accession>
    <name>A0A4Q9LSQ0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1274p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001274">
        <property type="protein sequence ID" value="TBU11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSQ0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1274p0010"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGS" evidence="1">
        <location>
            <begin position="62"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18472" checksum="A115641C4E99D093" modified="2019-07-31" version="1">MFDWHENKQTITIVIYSTQCDIKNIKPLIYGKKLVINKEISIQLYKDVSDKVFIKEYDNKVEIILTKCVEERWDTLLPINGNKNEDFRIKSENVDLQEISDDKEDQTALSFFQKIYEKSSDDVKRAMRKSFLESEGTVLSTNWDDVGNKKVDPASKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT03</accession>
    <name>A0A4Q9LT03_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1619p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001619">
        <property type="protein sequence ID" value="TBU10670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1619p0020"/>
    <dbReference type="OrthoDB" id="2192073at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="251" mass="28832" checksum="6F90A190AD48F080" modified="2019-07-31" version="1">MDYNVITANMKFYGGIFDMVNRDLQPYGVQVRGYFDNLSLDDYKVPYDKTKCMEGSPSQARSAMSRTFIQAKEKGQLGNRLLVFFCPNLLMTPPQTSILPFGTCDNIIGFTFGEIHQLKTSIYDSIFRMISRVKYKDMGTVNTSFNSELCRYTDNCISNSETVYGEYIRDLKSVRHLGTEEYILKPGAKLKIHDPNDDTYFLKAHGDGFRVFPTEDYSNEEELLLDGLSMGKVKDRENVRETRIRNNNKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTC4</accession>
    <name>A0A4Q9LTC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1004p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001004">
        <property type="protein sequence ID" value="TBU11868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1004p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020611921" evidence="1">
        <location>
            <begin position="17"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="656" mass="77904" checksum="D54ED165899F9E56" modified="2019-07-31" version="1">MKVNFFWLVFGSKCLCAELTAMKQAYSQCIKSDKIKIGECINDIVHNSIIKQKEAYISCENKKYFVFYDIKQENSELLKDIITVINNQNTPFYCSSLKYNPKEIFGPRKIIESHYNFLNSSNYFKKKTDISSCDDNVCHIFDKKGMCLYRRVKDRIGKTFKVFGEFTLTGSRLKHIASKIEKSFSKSDHMGYRNEDCYIATFSNEKLSNLDISIISNLLQEIYEQNNQVLNNVIIYIPDFLKTDINQYEEHLTSQGIEFNTLLFKYKIKGHVSMLSSDSLRTLKHFKSYNINYNSMISILLESFQLLPINQSKDGCVDRFFRYLKGKRVYFDGYQTRDLVNMKVKNEEFVSLNSLFYEFRYERYFTDDEMEQNLLRTYEIYRLYYKNKLNDCTFEYFVVYDGRGLLKYVASDIFQFLKVYKRCDTRNIDFYMILKTLEKYFLNENSMNDYNNIYRLHTLGTEEPIFISEDHIFETSINITENTTPFNEKLNLLFDKLKTEIVKYFEGISKSAIKYYNYKETTHDFDDTIPLIYFDGRIDSSEMFDDLENYYRGKYSNGSTIQYALERTFIEGKKRVKSLQDIESMEYSINNEIFLIIDIEEDLYIAKNEISLVLLFDEYNSCLRISVANSSLYNITHLLNLTKIIKKIAKESRKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN0</accession>
    <name>A0A4Q9LTN0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1459p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001459">
        <property type="protein sequence ID" value="TBU10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1459p0030"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="527" mass="61239" checksum="E0708A8DB4E9A915" modified="2019-07-31" version="1">MIIRVKKNIKDNENKENKRKQEYNEEIEIKNEKEINLEGDLNMEMKIDLENKIFEEMDEYTLQEYLLSERRLSIDFISKVVKDAMNILQLEKNVLEINVPTVVLGDIHGQFYDLINILSKIEIGKETILFLGDYVDRGYFSIETYIYLLFLKIKFPKNIFLLRGNHECERLTKYFTFKTECSYKYCDLIYYLFIESFKYLPLAAIVLKKMFCVHGGLSPGVRSVDSINSVNRFCEIPLSGIICDLLWSDPSPKYDKTPKSFFFNENRRCSYFYSYEGVCNFLNKNNLLMVVRGHEVQLEGYKLYKKHNGVPSVITLFSAPNYCDAYKNLGSILKFDGKECEILQFECVEHPYWLPNFLDGLNWSFPFVAEKIAEFFLDLLKSAYSDESSSSTIRDDIISEEMKKAVNFSGCMGIMREERECLNEMEDEESDVVFSTVLKYPSTENLNYVDAKDKDTENETLVDPEIVEGTTLEVNPSCSAPISKKLKDAGLEVLEETKVIPKGDVQGVEIKKNRSPWCFFSCLGWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTN8</accession>
    <name>A0A4Q9LTN8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1001p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001001">
        <property type="protein sequence ID" value="TBU11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTN8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1001p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="506"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="770" mass="87857" checksum="71368E710FD1752F" modified="2019-07-31" version="1" fragment="single">MGRKKNVGSEISKNTKIKAANDADEVKKSDSGKQKCKLHPPAISLPSSSYTTITHSPPSQTCSNMQNSGLASLPSPNTPLHSSVEVSACEPSYYMTNPCALAIPEGNRLMALQTIFDSVTADSKEWPQIVFFAVQTRFERMPKNGWTELHGYYNEKFGCTETLEMLKKLAQIEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISEKEIRKLPSKLVDSKVLNLINRVVGEYAGAHVPMTINAVARIIQTAQVYYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLPTSETKSLKKIMREFNLNLSSVTDISKALAKKNESLNVYEKKITMYESRKRFRKENSMFELFRGRFYRGLSERFLVYNWNKNDDAITYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDVICYEGTPQADWFYCGLTYLIPKGIPRRGSDYRPIASYDLIDHAYLTQCIENLNLPDKSSNLFRDSTRDSLSPLLFVLCIDPLRRKINEKYTKVTVQTDTESHSTNHLLFIDDLKLLTKDSSTLSAMTDEAKEFLEVIGLEINKEKSATNDKCCEDTATLLEGVSVYKYLGIIEYSRGIPTRSSFEELDDAVRAVLVKNKIHLRPGCKKRLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLAEELYYARKNELGRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP3</accession>
    <name>A0A4Q9LTP3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1373p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001373">
        <property type="protein sequence ID" value="TBU11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1373p0020"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="319" mass="36713" checksum="4E7FECEC50840493" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQEEKIIKAANRASEVDEVIRECKNDQGIPQPSSYTPSTIINNISIPPSEANTNTKVCLLNTLPSPLTLCIQAPWPNLCTIPISERLVVLRSILRSIEAERQEFIRSVLFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDATRFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDTTVLDLINRIVGEYADSHVPMTITDVARIIQTAQVCYDDETRKERPRSAWKESIESKISVLKLSKDILEKARRREELSSSQTKSLKKIMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS7</accession>
    <name>A0A4Q9LTS7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1454p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001454">
        <property type="protein sequence ID" value="TBU10970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1454p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24953" checksum="8D12881DACCFD3BD" modified="2019-07-31" version="1">MSALKKIKLLCSDNDSNLFLSQSSDTVINLKNISSLYYSSFYRHGKQLPLFSMSSSLEFFDFSGSYPEGILFLIFGQDKFNNLKKLNLNEIKIGKKDKGALTKYTGLHYLNFFSCCKISDLRFFELFTFSDTYSLIEIQLPTIEFSYFDFLFLSRLKYLKRINIYSLKLMFVGLYFPKEFLSLKEIKIAKMEFSSEQKSQFFEEFGNRINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTS9</accession>
    <name>A0A4Q9LTS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1433p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001433">
        <property type="protein sequence ID" value="TBU11005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTS9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1433p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="507" mass="58070" checksum="FA77605DEB15C634" modified="2019-07-31" version="1" fragment="single">MKKELALRTLLYLQILISLQISFTFLNSVFFIYKYEQLQNNRDISVIVFCIPSLVYHVVKLFFCYFKRYFIREETTGQYTGNGNIKGINNNILRDNLCVSNEIKGCEKVNGGIEGKESEKKEENKDLDNTALNTCDNDNTLIEVGIKDNTSLNIITENNTPLNISTGDNTPLNVSTGDNTPLNIYIRDNTPLNVSTKDNPPLSIGHMNNSLLNNNSKLRRELNFLKSFYTNLYKRGYTLSIAISILLKTLSYFIDRYFLRKYICCIFLSLINIIISINDIYYTSVLERLKSGIENGVLLSVFIDEIPTYMFVGFFSYLEWMFNKSVKPYFDLCAIVYLISGLLLWRVSRMGVIKEINDNGGFSSINSGRSVIKERNRKGFNEKKCVFKGKNGNECKYKGVNDCNDSYCNEWGVNNKNDKGGVNYMTTNINGINEPTNDIKDVNNIVNCIKGVNNCNDYCCNRSPDTIDLIQMSDYVSLYTEEERSIARINPYLCEDKFISNKNISMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT8</accession>
    <name>A0A4Q9LTT8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0345p0030</name>
        <name evidence="4" type="ORF">CWI38_1429p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000345">
        <property type="protein sequence ID" value="TBU03162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001429">
        <property type="protein sequence ID" value="TBU11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0345p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1429p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40970" checksum="ED9EBF4592D974A5" modified="2019-07-31" version="1">MNNQRREKLFIIGFVLLSSALITVGVIVFFWINRAKNEKTKEHKKNHEDHTKKAEINETKEYKEGKKSLKEPLVNESVQQIKPENVSKNINKHETATMVPETHENTSKIQKETNIEPDVNFSKPETIIETIISEKDIELDKNLNAVKLKIKFIDTLLYIFKVKLINIKIDQSTKRSDLDFSGDSTNSRSIGIVNSADSKFSFEGEDKNHNLRDFAEMNGGLTSDKQDWKNITDENYIAVKRPGGIGSMAISEFNYGKIFHCIGPSITNEKNLMNMPKNLQELRQGVSSLFMKAYKEARKQKLDLIIFKFISTGANSIGSNGLIFEPNMFTFCIYSGILDFLKNISEDEIKNIAFNLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ4</accession>
    <name>A0A4Q9LTZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1400p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001400">
        <property type="protein sequence ID" value="TBU11075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1400p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13308" checksum="7B4EEA21ED164014" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESRLNAEESWERASMGVIMRSEMHEELKPYLKEEKREEDGLKNFKLKNKAPFISQGGTTLEEPTNNINEESNLEEETEVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU35</accession>
    <name>A0A4Q9LU35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0923p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000923">
        <property type="protein sequence ID" value="TBU12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0923p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="62" mass="7338" checksum="B38BE63EC94F3D5A" modified="2019-07-31" version="1">MTFLSKKLYNILRKNSNADECRYLRLVYITLKTVKKISFDGRKGIESGSNGKRDQHFLKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC0</accession>
    <name>A0A4Q9LUC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0976p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000976">
        <property type="protein sequence ID" value="TBU11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0976p0020"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="467"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1121" mass="124168" checksum="718B87A541514D91" modified="2019-07-31" version="1">MPTKIKVLIRIKPSKSPSPNISYTPTTLKIKRKEKTQKYKFDKIFSKSSPLLSYIPYTRSLSSSTNMGNSNIGSSSGNIGSSIGSSNNSSNNNSSNNNSSNNNSSNNNSSNNNSSKNNSSNNKSSNNNSSSNNSSNNNSSTYTNTNTTNNNNTNTTNDNTNTNTNNTNNTNNTTFICYGSSNTGKTYTLTHLIHSIVSYYIQQSYSLNISILEIYNDTLYDCLSNKDILEGKGGVNNSSVLEGVNNNVDGYKGVNNSSNKQQGVNNISDIQQGVNNSSNKQQGVNNSSNKQQGVNNSSNKQQGVNNSSNKQQGVNNSSNKQQGVNNSSNKQQGVNNSSNKQQGVNNSSNKQQGVNNSSNTQQGVKNSSNNYKGVNNSSNYKGVNNSINKYKGVNNSTIKQQGVNNISDIQQGVNNSTNKQHPLNNSSNKQHPLNITTNRQHPLNNSTSRSTDLKNNNTIPITSTDLLSIHPITSYKHFESIYNIYTNNRHTNSTFLNRCSSRSHSIIQLTVNKENGNSFNDKTNIYNTCNGNTSNNSNSLFSTDPNPNLTLNTCINNPHSNTTHSNTLNNTYSNTYSNPTLNNTLNPTLNNTHNPTLNNTYTNTHNNTYTNTHNPTLNTNTTLTLNNTHSNTLPFTITLVDLAGSEDNRKTKNTGNRLKESVSINKSLFTLKKVINSLYFNYINIPYRDSKLTRVLQKYLCKDICYLICTVSYEESDIEETVRTLQFASQTKHVTVRDVSSKEMDVNCNNIYKDLSRRGIRDVSRRGIRDVSSNSIRELSKRGIRDVNTREAYSNREAYNVLNEKDVNCNKRYKSIGGVNYKDGNIKGIGGVNDKDSNIKGIGGVNHSINNYKGVSNSTNKDLTNSTNKDLTNSTNKDLTNNADKDLNLSTNKDLNNSTNKDLNNSSNKDLNKNTDKHLNNTSNDSLFNVLLLRAQQFEREGKKRKAITEYKTLLKMYDITGKEDLLNIKEKIKSLSNKGGSNYRGVNNSTDKQQGVSYSSSKQQGVNNSTCEQQGVSDSNSKQQGVNNSTNKQQGVNDLSNQQHPLNNNTNIHPVIHSKEEILKILNSGSYIEIKKIKGIGDKRAEIIINFLLGGNRFYCIEDLRMLFTEKIYNSIIKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUI4</accession>
    <name>A0A4Q9LUI4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0808p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000808">
        <property type="protein sequence ID" value="TBU12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUI4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0808p0010"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34814" checksum="BAD3B612F51C74DD" modified="2019-07-31" version="1">MRKRISADGKYYSEHKDSDTAYDFLKSDSCINDVKTHFSSVFEARKKIKKNYIKFIEFERVNLPSFDFFYLRNLKKLEYLSGCNLDDTQLDIFTMNTTSDVLLLEFFDDSRKLIQISNQPSLHFGTKEISLAGNEMQLEIIHSLKNFKVLEYLNFSNLKNISMENFYCDCGFKLYLVEIDLLEICYLEVLISVKKLELAKNNLTKFDIYQIYLFSNHKYMRVSFNAEVFSDFVKTWGFSFYNVNSDICNFLMIQLSLKNLKFIECKIEAELWTDGFRTFANSLETVTVMNKMLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUK6</accession>
    <name>A0A4Q9LUK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0797p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000797">
        <property type="protein sequence ID" value="TBU12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUK6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0797p0020"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="346"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="571" mass="66721" checksum="CB7899B6EC4907F6" modified="2019-07-31" version="1">MVNRNVIKNEKSDLFVIKIALQHFFSTHKGVYLVLFVVFSSIILSKYFDYKTQELYLLMEKDTSDSKLKSIIFYILLTEVLDISFHKLQQIVFVSLLTQYRTNIASSAFKYILYNGIKNNIDLTNGSIQFAVLEGTKGLENLIDCLVIYILPQLVSIFLFCRKLNSGFGNLISFMIFLSLAVSVYIQIKITKIKLKSKKINNKSRCKSDTILYEAFNNLETINLMSTEEYESVNYKNELQYNQKFYVHFERMNSFFIFLHKIFFSIVKTITCILFLTKNNENNDSGTKMRCLMTFINKSDKSIDSTGKLFTYIKESILNSKLVLDYIEDIRNEEENYLIISDLKSIKFKNVEFLYENISIFKEINFEIKIWKNVAVYSSTDGLNTLLIKLIFGFKKYKGEILINDVELKDIDNKIWLKNIFYFQPDFNLFNNTIEFNILYGNFNVSKSDMVNISKKIGLHESIINKIDEYQTQINDNDTLITVEEKHKILFARGILKKPKIIILSESYCKAVNQSIKSLSELIRSIFTEITIIFLTCDIKTLSFFDQIIFIKENGVDFCGTFDNFIKFNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV73</accession>
    <name>A0A4Q9LV73_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0702p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000702">
        <property type="protein sequence ID" value="TBU12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0702p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30602" checksum="BAFF49ECCE86C698" modified="2019-07-31" version="1" fragment="single">TRCEKMLGHGYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETKKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVESISFDRRRGLDSGLNAEESWERASMGVIMRSEMHEEPIPPLKAAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVU4</accession>
    <name>A0A4Q9LVU4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1060p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001060">
        <property type="protein sequence ID" value="TBU11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVU4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1060p0020"/>
    <dbReference type="OrthoDB" id="7978815at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21757" checksum="02E8290B8D16F939" modified="2019-07-31" version="1">MINNFNSEETDLIFAIRMCLEKCYEYKITTQHLFVDYNWRRRLIVQYLIDTQYLAYAENLAIVDTKQEDIESTLRILAAESGKAGLKINEGKTKYILINSLKIGSYIFERDNINALETIIRLVVLYASETLDMTKKDEVLGQTYGKERYREKILAEELLAKFKRIVGKGRKDPKKAQCIALEKLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW66</accession>
    <name>A0A4Q9LW66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">XPGI-like DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0972p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000972">
        <property type="protein sequence ID" value="TBU11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW66"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0972p0020"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09900">
        <property type="entry name" value="H3TH_XPG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="7">
        <location>
            <begin position="647"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="819" mass="95527" checksum="AD1EFFF60D0BB63B" modified="2019-07-31" version="1">MGVKNLWKILKNCAEEEINFDDKKLAIDISIWMYQYSSLPHNQSLYFITKRILKLIYYKIKPVFVFDGNIPDLKRKVCEERRNLRNYVDLSDLARKFIEKKICKICCKKYNECVHASVEKDNLFSKIYKNCIERLENHEYDWGDDISSMSEYEDNIFFDNNEYNTCDYVTDNQFTDTEKSIINTKNVSKNNLNFREEKKKIFRKEKCKVNKYNDEGKNIYCSNISEEEHLKNIRGKEIFFGNLTDYLDTKEYENLSKKKKLKYLVYLRGMSSYQDNSDMEKFSISQMENVKKRNKVTTHISNLGCAAKKRVLSDCKTYFEFEKNSKNIFIDEIFEENKKEIKSINLVETDEKEESLDEWLKEIQHNSFNYQEVNPVIDVSNEDSFNNLKIIESENNKSEYFKQKKECNESSLKDISGRISILSENEKMLGNLGSDISVNENLKTSKNIYSFDLNLESNIQTEKTSELIKINDSNNNKIFECKESNISNEKFINLKSEDNKVKYIDDLGGKSTDSKFEDNRVKYIDDLSDKSTDLKFEEENTQTIDLATKYSEEAKSESSDLKSYSESCTPHIPPMRHIEDITHEPKDRNDPNNLISKTSINIDSLQNTEILSQTQVIPENGITDIKISNNLIPHELNFAFAVQSILKAFNLPYIISPMEADSQCAYLNINNIVDGVITEDNDVLIYGANKVYRNFFKKNKVPTCYSLQNIQSKLNLNQLDLIKLCYLLGSDYNIGQKGFGIVKSLQAIKNNEVADSSIEFLKNIYLNSNVTEVKEYEIFPTNKISRKNDIIIKVKKVLNENYVDEQNINEIIKLIVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW69</accession>
    <name>A0A4Q9LW69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0567p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000567">
        <property type="protein sequence ID" value="TBU12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0567p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020555050" evidence="1">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="345" mass="41137" checksum="E77C6BF37FF73A76" modified="2019-07-31" version="1">MEKGMYLVYILIFKYLYISAGSNSSDHIYSNIYETIPYDQIISSMYVFSDRLNNLRENDFLLEFISFNMAANLVFCGAQSQMVSRKKNRIYELLKQNSLSGLNMKKNHDIFTKYQIYRSHLNNKLLSIEYLVILRLKFKIEKILKRDFRNEIKEFTKNIFLLNPGITNIIKERFKNKIKCLNSESQNIPQIFLQKNFQNCKMTKYFKDFDISFCDMNSYSAIPYLDVLSTGIYLSYNLKTTQTIFLYNLNDKIFQTLYNNFLDIEIIRKSIKVIIKMIYDTKIETEDINEILKSDFNLKFYQIYKRTFKNLESAYMNVLIKNILNKKILSNILKGVIRELKENTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWC8</accession>
    <name>A0A4Q9LWC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0551p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000551">
        <property type="protein sequence ID" value="TBU13038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0551p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="388" mass="47408" checksum="BEAFACE0469457E3" modified="2019-07-31" version="1">MNKKRINTCNIFIKRESIYSDLLHFEISKIGKGGMTSHYGKKYHKNPENLKLRILLRHMKSPVRISPESLNSIQEKIFDFYDCFRYHMKEYDFFNPTSSDDREIFLFFYTAYILKKPFDEFILEYLQEKDPEIPEKNLKVFINLIKNIFISTEINDYTYDSIEYNGLLSEKYFKNNNSVKSMINYYENSYLSLNFWNDISLFKSQKFLESCKIKISNLINEILRELKIPENLKQEILSIYHIFWELKRVLHFFRDYGFYNFILYSLIYVYEKKCLNLDFNNLYIVVDNYLRRFLYKKEISISLKTLYYSLFKINVDFYLKKRMNYLNRFGFYTENVHNIHKKHFHNIFSDKVNNLPFKMAISPKSLNKKSKEKNSYFSKRRLFFKKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWD5</accession>
    <name>A0A4Q9LWD5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0697p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000697">
        <property type="protein sequence ID" value="TBU12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWD5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0697p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="289" mass="32838" checksum="033CE4D860A5C7A9" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADEVKKSDSEVQKCKLHPPAIYLPSSSYTTITPPLTSQTCSKMQNIPSSVEVSACEPSYEMTNPCTLAIPEGNRLMALRTIFDSITADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKDVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKEISENEIGKVVVRTRKHPNELVDSKVLDLINRVVGEYAGDHVPESITEAAYIMQAAQVCYDEATRKEKPRFAWKENIESKISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWF5</accession>
    <name>A0A4Q9LWF5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0958p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000958">
        <property type="protein sequence ID" value="TBU11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWF5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LWF5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0958p0030"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="24192" checksum="112D0C6A2DBFBD65" modified="2019-07-31" version="1" fragment="single">LHPVNNSTIEQDPVNNSTNTLHPLNKSTNEQDPVNNSTNTLHPVNDSRNNLHPVSNSSNKQDPVSNTTYEQDPVNNSTIPYTLTNTLSTNTISTTNNTSLKDYNLHFKDDLVDKALNFIQSELAPIVESNSGLVSNLEDLMEYFVFGEGDSIEMRRRRVGGYVNGVLMSIYDGNSSELKEVLKGIVVGESKLSRKYNGSNVLGVRVIVFMHILGLGLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX18</accession>
    <name>A0A4Q9LX18_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0291p0030</name>
        <name evidence="3" type="ORF">CWI38_0469p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000291">
        <property type="protein sequence ID" value="TBU03462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000469">
        <property type="protein sequence ID" value="TBU13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0291p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0469p0020"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU03462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="103030" checksum="1C0C2DB44F48D2B0" modified="2019-07-31" version="1">MKNYISKNKYTNCKKNELSEIPGSHIFIRYKLILHKVLTFLILYYLTNMINCVRIRIGFTGEACSEDLVLECDEYFTHQPSDAYSETGSIKTSLQQNIHDKSYNCAINLTKNINVADQCRACSLKIKLKRRIEPVDYMQASHLLNNLQKKEYQMKKEHRMKISDNFSLKNQTASKYVEGGLTSKFDKSYLIFDYSSKYIIRSKTLDNYLYSGYDDLTIDIESITKDQINRDLFSFMLHSLRLCKNTNFSILKEEDKIKYIGLLCDLFVYSESNALEIMYKNLFSFLVAYKTIVCESPAFQTFGLDLKRIKQIFLPFLGVLYDEIEIKLDFILNEILFSKKDENFKCNFLYTDTFGGMKIRITPECLIIMKLSDSFKNEVLLPWFISFFNINGIKISFDNTYYSECINPDIYYSCLDKVDLLTSKNLSDYNIFSVFDFLIKTEIKFLDLECIFISKTVIDYISRLSYLETLILVKCVFPQHCWFLIEFYKFYASLKILNIIGIPLSTNFINNLISLQLEELDLSYCKIIDKSNHDKLNGISSILKIIKIDSSSLSHKIIDFFMKSSCLRTLSMKNIDFTKFSNKETNFSAWNKYFHSLNISGSKLGKQFLDFFSTDLYSENLYLENIHCQTDAHRILEQESLFRCTKYLSCTMIFNTWNLYDILKNYCFLDSLKLYDRSNYLMNWSEYDLFHSRILKALDLSQNMLSRHTLDFIGTFENLEELNLSRCGLNSGSFYFLRCIKKPFLLKKIDLSDNELNTFDIFALSQFKNIKYLRISFDNSVLLKYYEMNGILNFEKLEVLSLVHTTIDSYILSFLISQDSLIILKFEDCSISNSGLSEEVTYRLKHLVKLSLSKTSIDPEAMKIIHTYIKIGIQCVFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXF4</accession>
    <name>A0A4Q9LXF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0544p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000544">
        <property type="protein sequence ID" value="TBU13056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0544p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020324648" evidence="1">
        <location>
            <begin position="17"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="706" mass="84262" checksum="079CC6EDDD0B8619" modified="2019-07-31" version="1">MIIFLRLIFFIISCKFKNDLQIYLLLLNFGISRNKDVVFYWKETFSDESNTFNLKQEFVVSTHSKTVDNKNNSLKRKNSFCKIVVSNIEKFPCKFNLLFRKSNNEVNSGINKEINIEISNYDYNEFKILSDFLNDFYISKKNLSIKQFCPFISIFEYLETIIDENFYKIIDLLIWKVYNYLETDKRAFKVDFLRVERIFGVSKKMEDILFLRMYKNFIDFDPNNDSFFENYFIDFLIDEHRLEFLGGNLRVFSVSEGSISIIKKLSKKNELIFELFYCFFHIFNIRKFIFYNSSILFLDVSNILSLFVEFLDEIIFFNQIIKDETILRLMNDKKIFFDVFDKLEIIFVIFNVKRKIDKKFNSEKRIMAIIQAIKFRISDNFEKNLYKLIDCKGIPENKEYFITKNTKIREIRDLILMKNEIIKLFVYIRTSISEEILSLFDIFINLKSIEIYNFPHKIAKTSFNELTLILQNCRITEDFINLLVKNCKYIDIKNTLFYESGNEIEEFNIIHDFEDNHINVLLLLQLLDNLKCFAIPGKNISKILFTNELRSFLSNKTLENFAINSIESSSVKTIFFLACKIVEKFHFGSGFSPGTLKTLFFDIKMQDLKGFSIYDCKIDKRDKISFENLTSLIYLEIENCKFQNIKFHCLFNSEKEYVIEELILIKIELYRTDIDLITAFKHLNSIVFDCCYTPDKCFLKIDVNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ3</accession>
    <name>A0A4Q9LXJ3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0407p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000407">
        <property type="protein sequence ID" value="TBU13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXJ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0407p0010"/>
    <dbReference type="OrthoDB" id="2194163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11983" checksum="ACC87CA25D9475AF" modified="2019-07-31" version="1" fragment="single">MILSFLKVKYRLVEEVTKKIKRKLYSKLCSARKNELVSVSDSSRWLKRGNIGPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXJ4</accession>
    <name>A0A4Q9LXJ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0700p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000700">
        <property type="protein sequence ID" value="TBU12601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXJ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0700p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="576" mass="69097" checksum="EF473E0A2BEBB150" modified="2019-07-31" version="1">MQNEFITENCCKNVKKNLYKLPKKSDPKLYIKIPLNINDIEKNTNGILSMRSNTLRTFTETIKKSNDINPAIKFLLNLFYYEIDSYDENYSAYIYFSLKHNLPRIDDSTKEIGFTVISSEFIYNIESFIRFNELLNKNSILKKKSNEIIHNIFSESIKKDGSVKIERKDSTNNRNYEVIFTKNIFKYWGIRELNENLSFIGHFCFYSVIEEFCMRNIKLQQKETEPFDNFVKFLKIIISNVFDKLFLETDDYNEILLISKTPSILNKYTLKNINLGLKFEITSFILEIQELKDDFNKKYLLNQKNEKLMQNNNQSFILLEDTLDTFEIYSKTEKNNLLFIWYAIYSLLNEKYHKNELWMSSLIMASILISHKNIKEIKLENIEDIKINSEEIFKILRTNEIYFISEYNNFIKELENNFQNKLNTLYSIILENAARGPKIADVNRICKNLVILNSENTMIFHKFCEENIDTKIFLYLENIPYYLTYYYFVNKEIFIEMTTDFQIYLQNIKECEKSIRPFLDGHYQIKDKKMLFDKNFKYKKHCILTLILMIILIASFCYYIYNKRAHKKSFSIEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYH4</accession>
    <name>A0A4Q9LYH4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0634p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000634">
        <property type="protein sequence ID" value="TBU12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYH4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0634p0030"/>
    <dbReference type="OrthoDB" id="2201200at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="445" mass="53664" checksum="F7FAE62E515D128E" modified="2019-07-31" version="1">MSQFFKDFDDEEINEKSKKITKKAFFDEDSSEEKDKISKKEKKKNELQLLVISAEEDFSVKQAENIVKTFKKNSNIFKNDIPRFLKRFFLQIIEEKKSTASLKRQVNEILKKYEKEDTIKEDEVVKTEEKRTEVFENKLLAILEIENYKTKIETLFELSKSKNLQDSELAKIYMSLLGIFNNEIANTKSENTPKKKELLKEIFIVMNFLLEIFFKHDTLFYENIDLKKLFTENLNFYIVKIFDIIDESYFDSCRDLLKKTESISLEISKSKSLEFSFFYDNKIIENEIFPFNILYLLRINEYEKSKSLYLESEYIKTPTYFKVISELGIMAFYKQDFIFSFKLLQECYFEANFHNLENYLLIMCVIHEEKVINEIFFNIFLEKIRLLENNKLILKAYDSKLEIFRAYLFLYNFDYKKSYEILKKIEPRLECYDVLKNRVLKELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYI6</accession>
    <name>A0A4Q9LYI6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0298p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000298">
        <property type="protein sequence ID" value="TBU16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYI6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0298p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="67" mass="7634" checksum="B0F022A605D694A6" modified="2019-07-31" version="1">MPRANQLGFFKLNVGPTTLPLKQPCYETQKSKRAFEKTDDDYMINRVLQRRLGSLRAVAQSDSSTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYP0</accession>
    <name>A0A4Q9LYP0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0591p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000591">
        <property type="protein sequence ID" value="TBU12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0591p0020"/>
    <dbReference type="OrthoDB" id="2194045at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="224" mass="25927" checksum="36656FB40F221187" modified="2019-07-31" version="1">MNNFKSTWRIFKYSKEQLSEDLLSYCGNDLSLYSQTISHSQIYNSASKSQKWLHIYSHCDKLLEVSIDSIFIEIKLFINTTTYKKPNNNCNELFSMPISFTADSQPISQTNSQCDLSTTTKIILLEKIAIKNTYLYVTSKDTHIAIKQTNLPKIQLTFFNIQNALSFYSFINSNIGINTYSCEMQQKINQFKQIVGSRDIKIISSKKTIKELMCEFKKIVINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ3</accession>
    <name>A0A4Q9LYQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0285p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000285">
        <property type="protein sequence ID" value="TBU17604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0285p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="24069" checksum="8F99242A7C0B9ACA" modified="2019-07-31" version="1">MEKLAIDTNSDSVYTNNSLLTDNLEFFEITSSFTSVTASDYLMLVSVRYNTCMLKKEKRKKIYESKANEIVRERSKEDIDDNWKNFYKIQRNERFDEECAGITKAKNEAYNLMIQKKRDARNEEKRIHRAKKRKSMMTQMEPIQKYSTKHLSREIFRTMNDNRRAFISRTKNFISKMDEIINQVDKDNVFDELDDTDSYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYT6</accession>
    <name>A0A4Q9LYT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0273p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000273">
        <property type="protein sequence ID" value="TBU17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0273p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="293" mass="34447" checksum="189D7F6F71EC91D3" modified="2019-07-31" version="1">MFFLKLYLENFSTIVLYSLKILWNLTIVFILGYLDLSPEILRKDERFLFTFIEFLVSVDKILASYIKQGKQAKSIDVFFRIEYIFVEKLDIKLLEFLIEKIPIENMIVHDNLISSGNTFYTSQSSECIDKIMDDLKPLLQHLKKSKLLKYITVETHPLEFLSTEGTVFPYNTMFDFAELRLHHFGSFTNKEKITFKNLISMDLGFSSLHRDQINSQLLNRINLEVDVIFDFSIQNSLNYENLSKIVLKYKDRNISYGVTTITYKIFFNKNRIAHLIHKGSNYFGGEPLNIECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV3</accession>
    <name>A0A4Q9LYV3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0265p0050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8 9">Cytoplasmic vesicle</location>
            <location evidence="8 9">COPI-coated vesicle membrane</location>
            <topology evidence="8 9">Peripheral membrane protein</topology>
            <orientation evidence="8 9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8 9">Golgi apparatus membrane</location>
            <topology evidence="8 9">Peripheral membrane protein</topology>
            <orientation evidence="8 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000265">
        <property type="protein sequence ID" value="TBU17875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0265p0050"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="196"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU17875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="422" mass="49549" checksum="3E735675AF616423" modified="2019-07-31" version="1">MLIGFFTYNSITEDIFIKTTELMEKEVIDLILSEFTSASKKGTSLITEMFTYYFLEKEDVYYVLVTEYGFQEYNAIKLLKTLIPYDFPSLLFVLDDIINKNSFFILDTESLHNIVEMESQEEKIHEMMMKNKELDAIQKQKELKMRKKMSDIDLQLEKVKNLEIEIRKETILQSKTVEEKEEIKKEKKPVINEDREESILIGIKEKIKIVVDKENNIKNCEVEGDMNLLVRNEEYKNCEIEFSIQKKENLKFNPNLDKDSSKKNKLKGTKGFPVDKNVALMKWKYSEIFLPIVFTFWPSEVGIDKYQISMEIVTEVENIEGLKLFFPLKNIKNVILESDKCVLGKEFIEWDIGSCKERGSSENIEFTCSTDDVNNVFPIEVFFRCKSIFSGLKILNVKEKENLDCFSVDEMFEVDKFTIVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYV8</accession>
    <name>A0A4Q9LYV8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0420p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000420">
        <property type="protein sequence ID" value="TBU13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYV8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0420p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21115" checksum="0DFF7258FC457388" modified="2019-07-31" version="1">MIYFVILCLISCEIDNAKEYIIEIADEPQTVLSLINGKLRFIEIDNLPDMYKNKAEIVQFLGSADTYEIKLGEYVICKDKQSFRIGLCTHYNPNTYFSIKGSGMGFTFGLESDKFCIIRGERDDEDKYEGYHVDLDYCEKQLEHKTFNITEFIQQKSFELNPGYKRDIDKETMAEYYFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ01</accession>
    <name>A0A4Q9LZ01_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0377p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000377">
        <property type="protein sequence ID" value="TBU13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ01"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0377p0010"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="45455" checksum="019760FCF0BCB338" modified="2019-07-31" version="1">MSLEKLKDVISNIANEDPEIVDERISLLGSELRGLKGEVTNLDYEIGIRRTSTSENYEKIKLHKTLPYLVATVIEVLYCEKTGDVNVVLMTSTRVNMLILNPGLVDPAKLLPGTLVGVQKESNVILEIIEPEFDTRVKAMELEERPLENYEDIGGLERQIEELNEAVVLPFLHPEKFIKMNIRPPKGVLMYGPPGTGKTLMARACASKTKATFIKLAGTQLVQMYIGEGARLVRDTFALAKKKKPTIIFIDEIDAIGTKRVDSDRNGDREVQRTMLELLNQLDGFAVNDDIKIIAATNRPDILDPALLRSGRLDRKIEFPLPNLEGRKRILQIHSRKMVVQDNVNYEELARSTEGFNGAQCKAATVEAGMRALKKKREEITQNDFMDGIQDVSAAKKSRYHYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ64</accession>
    <name>A0A4Q9LZ64_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0239p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000239">
        <property type="protein sequence ID" value="TBU18508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ64"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0239p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="292" mass="34929" checksum="C377B485093EDF9C" modified="2019-07-31" version="1">MSINSNFIAAKKFIYLIETNKDREILFYEEIEDKLETIGIIHESFYMNVLNNSNRKSENKLHRVFTYKKNNFVNFELLKSLLEYPTYENLITRIECNFNLAYILKTLNDISSIPDEANIDYLNCLLLTLRSLKAIENKNISDFIRGISFRIFRKQFTNNSIREDLKLGYLFVQNELVSWNLYVKKLLIGTFLDYLMIKHNFINENLVISINTKRIIDDTTFNKHIPYKSLMINDHKLFCVLENIFKNRNILNTFQILLNELNIKSLILDAFKYQHLEISIMLCFFRYVFLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ81</accession>
    <name>A0A4Q9LZ81_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0488p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000488">
        <property type="protein sequence ID" value="TBU13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ81"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0488p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="56485" checksum="F77B16E990E5BA8A" modified="2019-07-31" version="1" fragment="single">EDSRGIPTRKSFEEVQTKLIARVERLCRTRLNARNLFQVINQHAISLINYHIGVLRLEPGDFSKLDDAVRAILIKNKIHLRPGCKERLYLPRTELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVENNNKTHLSLIKNFLKIKYGLEEEVTKNKLKEAQLANLYNEIKNRKLHSKLYSAKNNQLVSVNDPSGWLKKGSVRPHNKAVYVQHCNQSRKTVDHLVTRYEKMLGHDYSRRHNEVVRCIHLLLLNKYKSHSVQEILDNEYAEIKVNTRIKTDVKIRCNRPDIFILDKIQNRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYIITWDGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFYRRRGIESGPNAEESWERASLSVILGAEIHKQPIPPLKQVDNEEDDVKKENTKNILPFILDDVTRPEEPMIDMNDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZI8</accession>
    <name>A0A4Q9LZI8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0213p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000213">
        <property type="protein sequence ID" value="TBU19300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZI8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0213p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="600" mass="73209" checksum="581EDAF00B895820" modified="2019-07-31" version="1">MKFDFCSFYMNLFHKSLFLSILIFIKHSSERNVRFNIPYHYEESCSNILLKETKPKCWCQIQRSSIFDTDEVEYCKNFSRKDKNVQYDEYVISDVEKLNLKFDTFYKFNNINSNLEIFLCDHIKKSEFLIFYEFLISYYLLNNKMTIDKFYTILYFLEYFRVKQDDKLRNLMKMILYSLSISDDIKHFDLDKVSFHFSKQVYFSHELFKKISQEYFKIMNFKMSSFLPFFIKENEYDISNRYKGLYSKDKKHVLEINFEFTLFFNEYKSKNRKSKKLFILLLNTLDIKYLNDNLIYTNQTKIVFITSKFVTNIIFKDNLSKINEIIFYEDNILNKNYKVMKILDIENLNTIDRIIKNLQHSYRKSFKQNSIFDDKNMAEIKRQFYFKVFKQDELKNKVKIIESLYFNSTHREIKGSYENNDVLTISNSEIVMENNMASLKEIFVEFSNRFEFNSFMKPNIDFRELNLINRDYSKYIFEILGRLFFEMFVEKYDLSRIKKIYLCNISIDKLDFEALGNLLYLEELEMYRTKFKNIYFSELFCTSREYKIKRLKFTKINIKESDFNFISNLKILKTLQFYKCKIQTPTHSGTNMKLKKEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZL8</accession>
    <name>A0A4Q9LZL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0312p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000312">
        <property type="protein sequence ID" value="TBU15421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0312p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10941" checksum="BC25D8165D9D8F17" modified="2019-07-31" version="1">MGRNIVENTNKTHLALIKSFLKVINRLEERATNKKLEKKENNWLQDKVVCCYICTELFWEAEDMYQHCDAPGDSMICSTTRFEERFVYKCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZM9</accession>
    <name>A0A4Q9LZM9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ZIP zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0500p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000500">
        <property type="protein sequence ID" value="TBU13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZM9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZM9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0500p0010"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="315" mass="34832" checksum="8867BCE3A2797190" modified="2019-07-31" version="1">MGNDTILMATMTFTISALLCVVPKILTKIKHVKTAFPYMTVFSAGLMLSVILQDFIPHLTSDGCHSSNTKICPVHKRTISKCPDDCSAKQKSLDDHHHDHKHHDHSSGAHSHFNYGFLIAGVTFIFLLGIDSIVLKHSHCDNRDLIENHHLHDHDKFGSCNTESLKYSTSKLQAFVFLISLSVHSFFEGLVFNGSGSMKTYEIGVLIHKALESFALGVTIFSTKFSKVTIFLLIFVYSLLTPLGIVLANGISLNHITENIFNGLALGSTLFIIFVEMIPPNFHSSDDNIAKVAVLFAGYSLTSLVIFLMHLNNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP6</accession>
    <name>A0A4Q9LZP6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0494p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000494">
        <property type="protein sequence ID" value="TBU13235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0494p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020610005" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="70610" checksum="EF87902C541E797B" modified="2019-07-31" version="1">MIFFLFLYRVFLTSPLVSNGPFRLTVANNENLVLTSHNASVRMKDIATATGVSEVIMEKADPQSSDMYRIRIGQKYLCKKPFDAGVVACDTMDSNSVWKVETGPGGFVMRNEKACLVKAAQDNNTKLGGFYLNTKDCNDQNSEKYFRFVPTQTTQPTVVYTPPPDATQQVQYSNVSIGQSPNGSTVITQNSSVIQGDNTIEDKTVVVQCDDQPSGCEQQPSYTYSTVPQTVPVYEPQPVYENFNSVNIQPQPTAIVEAPVEPVYVQNVVPSAPVPPPVVTHPNPRPMPVPRNEPAQPQVIIPRIEPSVQPVGPPVLHPIQRPIPQPVMQPIPQPMPQPVMQPIPQPIVQPIPPPQPQPVMIPIQQPPNIQPVNPPFAVSAPPQQPTPVFRPQFVPQHVVEQRPEPSQLPLIVQKTLPTPPSQCVVAPPSSQQPPIQWPIQLPIQQPTLERQIGFTLPSPKENKPSEACIVEPIPVNFGTNNFKMSYLPAPQKNISDLYTPCHAGMQGCESTNKVAYVNPQQPRIVPSVSKSGCDAVLNSALSNVPTFVRNSNECEVTSNNFTESPLVVNDNKSITGVTGCNAGVSACEVVKTDPLNVDHMPTLEVRKGCEDQSACAEINQPGKVSFTEDANPNGYIYIHGVPPVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZV4</accession>
    <name>A0A4Q9LZV4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0475p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000475">
        <property type="protein sequence ID" value="TBU13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZV4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0475p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="94575" checksum="4F97B0732C9DB194" modified="2019-07-31" version="1">MIICTIFKKKKFFSTKLFFNLIHILGIFLFTQTVTSSLFTYRLIVNENSEILFFEEERIESLEDKKPVEIYNCCGIFNLIRNYIKNHRPVFIYRKDSPIQFEVLNNFLVSSAPKNEYKSKVIKCGFDISYYLRLSNDIRKSPKKIDYHEFECMVKTFRSLKAILDKYAIKLLQAFFEKTFIVRNKTNRKNKCLEFAEICSPYFSSKIEFSVMKYYITALLNNFTLKCEFYENNLVLMENIADEYDVSLLDVNIPYKNILINSYTVFRTLENILEDPYTLEAFKFLLNEMNIESFVINRGYGCIIPDISFSFRTISIKIFRAITISDFASSYGSFLLQLDSAIGKNIEYITLKCISLSIDTLKILLNKTMIKGLVLHRVNTPESLNFTPIGEFFYDRLEYINFYGVSTENKWWADFFNRAKFKKIIIKFDKDYADKNFITEFYKISEIRRDVLYFDVNFHCEKISNEFCQALKCFVNLQTLKLNVYIIDYSSNRNIIETVESLKNLEFITIIQRKSVYEVSESHILPSKKSNIKYLHLENIHSTDKYMYRNFFQNNRSLNKIVQVKSRISQYELEEIFALENLDSLSLTLNYFGYDTCPSKMQNIMSTKIVCLNLSGNGSKFLEHFGILGKLDCLQYLKFSDCGFKEGFLKNINEKCSLRMLSLFYIRGSLDIFDFEGIKKLECLESLNISRCKLLNCSFHQLFENCKFVKSLRRLYLSHVSLNEQDLQCLKTFINLKELSLNLDQFDLPTVHYYLIAIPLKLYISSFVAKKEEGFEKFREYLRSKNINIISRYDCFEDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M012</accession>
    <name>A0A4Q9M012_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0170p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000170">
        <property type="protein sequence ID" value="TBU19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M012"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0170p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="50857" checksum="1FF99D655D106467" modified="2019-07-31" version="1">MNLCILLYVSETIKSALRPIQKKELKIDFVYEILCKEAYRQYKEKVLGMHIVFEYNFLILEVIPNFVDECDLEVFNYLYREKLENTFLYLTTLIKEKVTVFKNRIELIFEIRDFEVFIFNTRKICKIHIDSILYFFRKRSNFGILGRFKRKKYVFELISRLLNYLRRTLNLISRSPDIIIVKMISESQLCTSLTLQNFLVSLMVHYNLQISCYHSILITKKGKKEISCKKNLANVLKIAFTSLFYVKYSYYKLEKEEYGSLLQRFESISNHTLKIRAENITSIGTNISSNKYDIKVSCFRSWIDKEPKNNIIRHSCIYVSLNLNISIVLIKPEKIKKSKKEPEFNDFRLKLVIKSSSNQNVTFDIDYNRKNNSVSGITCIEDCENFLKYGSIKEKLNFIIRYLDSKLDAYFQTNNYRLFQTEILFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M051</accession>
    <name>A0A4Q9M051_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0065p0030</name>
        <name evidence="2" type="ORF">CWI38_0390p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000065">
        <property type="protein sequence ID" value="TBU04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000390">
        <property type="protein sequence ID" value="TBU13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M051"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0065p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0390p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="102" mass="12475" checksum="2DFBA1348EADEB36" modified="2019-07-31" version="1">MISHCLPNDKMTLDTYYTILYFLEYLRVKYNDKLREVLRLCFVNLSISIVTDDFDIETVSFHFSKQEYFSHQLFKKLSQEYFKFSKFKINMIDPFFPKKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0C4</accession>
    <name>A0A4Q9M0C4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0420p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000420">
        <property type="protein sequence ID" value="TBU13475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0C4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0C4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0420p0020"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="415" mass="49016" checksum="1C50BAA88F0C64EE" modified="2019-07-31" version="1">MDLVSLQSKIFKDPNNYLEEYTEQLEKYKAFVELPIVPLKTLSTLLSFLTTVSHFYPSQYSSLIINHLSVTTNKLLKKEIFTNILILKRKKLITEEDFFTSIFLHTSDFKSVLRMCVKEISDRKTVEIFIKYVNHGNEKQYFFALFCILYCYEIKKYEELEKIICDNLFDKKGENMCLLYFLNLIDFSFSDNIYEKENQNTEKENENVENTENNSKILIKIGEIKAEEICKLLYKDLRLNKMMRDIRVKKLRVISVLKKFYNLKLKIFDYVVKIVDPSKEDLGQLMTVLIECLTPDEAKKGVDMVLDKFCNLAKDDDMVVYGLNILKEISVRFDLDVISYLEDYKKSKSKAVGYAYKMLVKSYNEKKVVGNRSLLYVRKKASEANKENKKDSTEKKNKYKNFKKGNKRRKNNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0Q8</accession>
    <name>A0A4Q9M0Q8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0111p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000111">
        <property type="protein sequence ID" value="TBU20209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0Q8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M0Q8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0111p0010"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="21025" checksum="3314578621F32B9F" modified="2019-07-31" version="1" fragment="single">MEELYSYIYVPRYLETRIFIEMKNETKKFIRKFNNILYTILCLFYKRKCISNVQIIQSFTVLFGFLLFRILNPAEIYHYIRLQGVMKLYVLFNVLEVADKLVGVILNDVTKVLLSISYFNISSTKTCTCMKDSKYRKDCENFFKNNIDIPPMKDNDYNNNTCYKRDCEDFFKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0S5</accession>
    <name>A0A4Q9M0S5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0103p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000103">
        <property type="protein sequence ID" value="TBU20254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0S5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0103p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="63" mass="6974" checksum="F98F86613E853C03" modified="2019-07-31" version="1">MKKEKNVLEESEKEGEAEDEIEEVVTIYVTKKAVSASSAKSRKSSKPGKSKKSGKSRKSSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M113</accession>
    <name>A0A4Q9M113_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0088p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000088">
        <property type="protein sequence ID" value="TBU20329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M113"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0088p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="286" mass="34333" checksum="1A8886561C316747" modified="2019-07-31" version="1">MLSKRKLAALRKKDQPFFLISRLKQPKWHKLWYRRAKNFIYKYLFFVFFVIIDLIIVYSLEKIFNGNIRIRILFFVALIHVYQRAYFSIINFSFYSQLIPKNRYEVILRIGILLTYLMQTIGDDSTRNNIFVNFKIHNTFIAAILGSLSSFLSYILFHFTMNLFPVFLKEYQNFPRILIAMWIALFFFVLVSCYDLNCFLVYILAELEFLLLLPSYIVVGLTIAINPYFRHLRRNYLHDILRSIVYICIQWPFIANIFKSIYSRFIIPQMNLNACKNSSLNLNLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M116</accession>
    <name>A0A4Q9M116_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0092p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M116"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="795" mass="94180" checksum="2A58D42FB6A5F535" modified="2019-07-31" version="1">MYFKSRKLRILTEKNRQRIFWGLIIYICSIYSTAVSFFVINDKSCIFDFIANDSILETSEQQNNSVNSIHAEEKITFLKNDIIRVESYNTNPKFYNSYIVTIPYKDSMLLNSKYIKDLFVSNAKNIRICLKNVSYTGLLLFLKLIDNPDVSINQMKIQDFLEILMFLTILDIQKSKARDGFLKVILRNIIFSMANINSNFDYKKYSENRRYESIKKCIFRDLFIFFIDTVTFKTRRTQNFIVLSEIAALSINSPYIYFSSKEIPKNNSISKFYLRFEANDIENISKIIEQEYLINTWIFLNKIANIDILYLIFNEKSAYKKAIILFSNVTFHAENLYIYSYENPIKLFMNKNVTPFSKKLKVLKLKCNFTTEEIRKLLNVCKTIGEITLKTIILDFERLGLLIDFFIKNPDKHCKVFCTTYIFLGTTIQFLRNIPNNLSLHAINFQKGSDIVNKSLEYMPFFQTDNYYYIHTSNSIIPNKFVFLELSNFKNLTLNYKNCSSPYKLDCNVFTPLKYFKTIKYFTLQNIVICDELLLYFLESNTIVLFRVIDFVCNYSLKFLENNDTYNRKLENINFINSLSYFDFGIMIYLSRFERVVGLKLIYISINSLKIYFKNIFNNILGSKFKVIRQIYLLILKITTKSSTKEKCNIFKLIYETYEISDLVQIEYCVYEITETDYYFFSKMKNLKVISIAVRNRSKIIEFCRLLYNYEPDITINALYINVSRIQKNDIEAFKKLNKLSVLSLLCDTIDYETVSIIKKSDFKKTAFIIREPVRANRSVKINTYLDSEFRNNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M180</accession>
    <name>A0A4Q9M180_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0069p0080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000069">
        <property type="protein sequence ID" value="TBU20450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M180"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0069p0080"/>
    <dbReference type="OrthoDB" id="2195025at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="133"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="638" mass="75448" checksum="20C0DF75CA7BD533" modified="2019-07-31" version="1" fragment="single">EVEIERKVIETEKGFVLEENPVLVTFYFEKADLNVFENCNEDVEVSDRFVRKCTLVSSEDFIFSVVETLFLDKMPLQEFKEKYEVRKPNSEKICPEQKFKYLNSDEIKLIISSKRKNLNTSLIFLKQKGSGLCGLFNLGNTCFMNSGIQCLNVYEEFIHYFIEESYKMHINKENPLGSKGRLAIAFSDLLREMWLENKTVVMPGAFKRVLGNETGKFVDFQEQDATELLDYILNFLHEDLCYGTNSKKEIIEENPKEYWKKYLEVNRSIITELFYGQVLSSLECMECGEVGKKYEPFMYLTVPIPEKKKFHFGVFLSFDSDNRIPIKILAEIDWTVEELKKAIKLRYATKLDILCVSVKNNKIVEILKESTKLSSIKTNIYCYEIDKEWSPENYIWLNIKILAYIFLNYNFNFIFLLKLENNTVEHIYEKIVSKIEPFINSSNLVFGYEKWKDKFEVKFSKKEKNINNFGFVTAFFKDSEFTDLFGKNFNIEKNLVNETEKNLNIYDCIELFTKKEILKGVEAVFCEKCNKSTNRSKKLDIVYLPKYFIVHLKRFCYYKGYEEKIGIFIDFPLEDLRIGNYKYNCRAICNHYELGAGAGHYTAYIKREEWYCMNDSIVMKINDVKKENAYILFYEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E0</accession>
    <name>A0A4Q9M1E0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0267p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000267">
        <property type="protein sequence ID" value="TBU17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9M1E0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0267p0030"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF426">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="2056"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2364" mass="282308" checksum="8113D6698AF825D4" modified="2019-07-31" version="1">METIHTSTSNKTRNQKMSILIASLCLKEDISDIFMTSDDPFSISKIGKICILKWNIVLDKYEKTLSGYRNQHFSNNIQIKQFNGAIKKKVLFIFKFLIYIMKNTFNHELYIIDNLHSDYLNSYDLDISYNSFLFHNEYCNGFSDSFNEISVKYFNSQNFSFYLEKDIQINQQKELKENRIIFSFNENQNLETFKKAIKDCLKSNKTPINIYEVHKNFKEFSVCNLQILRYLYYEKTDFQKLLSIEILANILTAKFYYTYKLELLLFCMQNFLIANFDDTVLASLQILAENVLLISKCKYNQENLISNQKLIKEILEKYQRFPYRFRSEKYKLLFTKFFIILNFLYSDSKIPEKDYISIREFNFVDICRFLPYILNILYNNAFFITFVDNIFLKSNTEHLVNSLFDLIDLESTNKSIPFENVIQTELYCDFKSRLTWLFRLYRKVIIHISDSELYDEHERLISLFLKKACFIVKNFYRYDFTFVDFINKNIIKILTKMNAKNVSEFEVTTLEILFDYCIRKRMCFTVTACKNVLYLGILITSSRFYNNFPCFIQELLDLYLKSLEFSIFLNIFPRISTCIQSNAVNFLKYHREFIINFDQIIDNLSLKEACENTELNVYVNLIKHCRKSLQTIETHIFFLKKNDKNTLKRLFYDEFRLFFYLKFIYNILWLKNIVLKAEIKYNLHRLINIPKKCYKKENIHLFKFINRLALCKINPMFSFSLYMTETTTYDISEFQTQILNACYTHNINMLSTHEFLFEMMMGLEYISTDLYYVFSHTDITSKFNLVKKHIELVSLIYEKIVSIYTPKWIQYNSLEVTVNDLLSHYDTIYSSEKNFIESLKEHIYVLIYQNIMFLEQMPFIMHSNNPTEYISYIDLLHKISLFTTDYDPNILFIYYKYIKCLSIEIFELKLDNLIYLLKFYTQQLNKIPRKSPLEFYTDNNIVYLIILKFLMNMNNLKTDLIDFNLPKILNLMIENVCLFSEYYSHIFLQHIPLLKNIEKSISKLHMFIKISDLILLIENQLMNPNSQAQALEITESRYLYFFLIGCFENFYYLDFFIEAQKKFDYFFLFIFNQVNRITNPKKHFYKKPNSVLEYLKILKTNINTNIENNKNMIYNKESLLFSDIVNVSNDPKEVLLYLISLIRLANYSKQISKIDIYHYFKTEIGFKYCESIIGNVLNTKNQILEYAYTCLRNLFEDEFYLISSFAYVLDSYTKLPKNIFEYFNQKMVYKSEVCINYDNFSSLITEDDMKLKIEILQDMIMIIAQEQHSYRIITLQFLSEIISTFPSLLHFIEKETIDEFLNNFISNKIFDDFISLNNSFRWSLDFRYGYFITVTLYRGDLCYVEYVIEKICVLAKIKDFDYSYNLFSLIYKILLSEICCCKYIQYLNTINHDFYDENCRFNFEKRKKEIYHIFLSNGILETLVNKFEQNLCSSSHIIMLHNCLLKLLNIFLSYINCGNIKFLEKYLMSSIFQCYLPSLYNIFCHISFSLINDFNIYEISFLENSDSLEYINISRNELTNLKNIDFGYIMKYHIGIGDFSDYKKIIFSNSEIDSKIVNFYAENINDIKTVIGISIWKNSDEQIYDNLKNKLKRYNLSEDVHEMIYSRLILSEERADFRKFDKKKIEWVFKYEDFIREKYVSKICKKASLDEKNKDGCLSTYTSSNLDVKTVCNKLLCDLYILPVKECAFELIEIIKNLILLDVNKTFDEDFLKYYCTQVSRLNSRTQDSYFNENPLKFVCDKMQSYSDDSVLELLLFESLYLHVNTDRLPIDSIKLKNAQDSLTSNASKSKNVSQNILYQILCNQKKIIDSHLTLFNIYLYYCDKIGFLLLKGYFAEDETILRAKSIFCKYDRFLNSFDLASIPFKQNDIDYIYKSLEYIATSPLFIFFRDFNSYKNETIVFLFKKYLEIIAKCCQVYSYVRNRIPNDIDLIEYTNKFIFHDFMSFIFGISNKIYFPNSEQIYDLISFYLKVKTIFHDNFDLLSSFKYISLETKIMFLTRPTYFSDSVAYSAFYLLINPKNIIESTINFFETKSTEEILCENWMAKFTTEYGEGIGPLYEFFLLYSKAINENIYFMPFRTNDPVSIFALSDTEEHNKIQKIYYYTGIIMAKSIIMNSVMGLEFIESFYLFLAQEKFCIEDFKNIDREFYENYVSLRDVEDVDSLDLDFTVLAAVNGELKMFCLSEDGYSKRLTKENVEDYIQKNTEFKIYKGMKDYLDKLKEGFNLIFPNTLHNFFSYDDLKIMVEDKKELNITEWKSNTKYSGVYYSEHPTIIWFWNLLTGFDDSERHKVLKFITGLDKLPTGGFKSYKFIENPFTIVPIFSKDSLPSASTCFNLLNLPLYDNEDSLKEKMRTAITVDYYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M279</accession>
    <name>A0A4Q9M279_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0045p0090</name>
        <name evidence="4" type="ORF">CWI38_0021p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M279"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0050"/>
    <dbReference type="OrthoDB" id="10661651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036357713" evidence="2">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="143" mass="16289" checksum="8495A312A2C27318" modified="2019-07-31" version="1">MFRFIFCLHFINCFLGNFFEDTNFLKSDYNLPNSNKNIDLSNIAGNVSSSGSSGGDEQNENYNNSTQPDTINDDSNNTLEDLNANEKSDKTNEMAKNNGDEEKYNFNWKPRVRKVVIPGEPKRICIVKVIPVPVDKYGNIWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M290</accession>
    <name>A0A4Q9M290_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0223p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000223">
        <property type="protein sequence ID" value="TBU18891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0223p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="255" mass="29951" checksum="2C806B77BFE709C9" modified="2019-07-31" version="1">MSFWDTQAFKISAVVVLGLIIFALIIIIIGYCLAGNVINNFEDDFKNVSETDRFRNHLSKIIDTNIAFFWIVKGAKIFWIVDPKDNVIKIKNKKEYLRNGKKIKSFQIDHNINEETLGRANKSFRLFEFDASRFSKILRNFGLLAKIGLMFRKNHPLKEIHAAAKMFDKELNKDSRDNQAKMVILENLDFKNITIYKLRRTEDSEYDFEGAVTYLTFEPFQINDKVCVISDFITYILEKVYKDKNETNYHIQDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2B0</accession>
    <name>A0A4Q9M2B0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0196p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000196">
        <property type="protein sequence ID" value="TBU19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2B0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2B0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0196p0010"/>
    <dbReference type="OrthoDB" id="2194526at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="20838" checksum="0EBC48D42DBD80D0" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNENKYDFHVGETPKCIECENDNVLKCLAETSGSNDENLSITTIPTLRKQKVSINDRERIIEKTLEGYSIIVRRYLNTGLVFVDKRSGDRRSKLTLEIKENLQAYVDLECTKTLYDTFNIDVSTSTIDRALREFHYTLKRVTLVPKRRNTLSTIEHRTNYATSFRELEVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G6</accession>
    <name>A0A4Q9M2G6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0011p0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020875461" evidence="2">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="22794" checksum="D1AFF4FF27FBCF82" modified="2019-07-31" version="1">MTISLAMLIGLLGMCTCYDILKKAEFAYKNGQNFLFLSPNTYKEYVSYALNNPHIVHLLIIAISVILATIILSIFRGIFAMFYAILLIFVYKEGFHITAFAELGIQNEVLRGIIFVTVAVIGFFIIAVKLNEVLFGLLFSFLGSVLLLITLETFLKQKWGYESAFRNLQNRILPELRSDSLLILSIMVAVSFGIQLSSIIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2R7</accession>
    <name>A0A4Q9M2R7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0195p0020</name>
        <name evidence="1" type="ORF">CWI38_1118p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001118">
        <property type="protein sequence ID" value="TBU11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000195">
        <property type="protein sequence ID" value="TBU19816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2R7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0195p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1118p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="50096" checksum="FFEB88C161F19510" modified="2019-07-31" version="1">MINLIDIIFISMVLCSDESQNLFFDPKENLLESDNTFPGIFLSIQNLCSKVIEKKEKKYDILLKKGFLVFLSNINVFMEKQSEFQFIFDSHYKSDSCFLLLAQIDDILAKKDLSEFFIKNSYDCNYKIFNRQRKKNGKMKKFEVIEYEEIKKNSCYLFKFKLPMSAENLFTFIKKVQGNSNFFKKEKENYLCVMFKDFLSGVERSIIEISLKNLKTRKLDKNTVIYISINKQYFVCKDIYPVFHRKHREMQKIYGYFFSLAMISSVERENLKNIPTSALIMFKKINLVKEYHKKYYKAVLSFYKYPDFTLEDFNCKKLVYSVIKRIIFGFCIEINIEYKPMFLSIISKKKYRKIINLKLIWDDFEENFIELTLSFDSNDTMNKFVYRRSCYADTHEKKEYQSLEEIRSVFDAFLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3G0</accession>
    <name>A0A4Q9M3G0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0028p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3G0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3G0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="25953" checksum="E23018F5B1243467" modified="2019-07-31" version="1">MLPYEVNELSSVLSYYIEYVKIHTNFFHHKFLTRFICLIVCLIPQRDQPYLIRYKTELLSNIISFAKLYEYSRCNKEMNDFEKTRMVSLFKTRLKTSEHREYICRKPGIRPDKIDSDCPLIIKNIESSFYHSSNIDNEIIKNTKVIVEESTRSALKNYLKSGSFEQIYSFYLYLKPYFFWNKWQDLNDKIILFSLNKFFFTRIILIRWCILICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3W5</accession>
    <name>A0A4Q9M3W5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0073p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000073">
        <property type="protein sequence ID" value="TBU20422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3W5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0073p0040"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="93514" checksum="BE8693F48F0211A2" modified="2019-07-31" version="1">MYSLVRLQLFLASFFVKNIEILCLKIQKWFITYLGVLAVLSCVIIPKEVNCASQSKDGTIEFGLINMNLRKNIADDILTTAEYWVYRSNEMDQFRFCSGRHFFAANRIYPEFFVCPHAFSFFNHEPLHIFKVDYINDWKIKFRVLNDHIYENSNTPFLFHGSFDVPYPLFSIFAGYMSCDPVVLSENLSYEVFYKLIKILDLLRPISSESLNKFYSSLYKNGLMNSIVFADIVNDAHNYRTRYFNQTRPQEAFMYFFGVLNPSLDACFIPNIFVVSIFRKRNQCIDQCFRYTEEIQNLVLKISADSLELLMATPSFNMAIFNWLLLITKISGFYFDNTECSFNPIKCPNVCGFIKINVPKKSPNSLKAVSSTFLLNLSDVNKRRIAHLRFINVDFCFDKIQNIFKENNVSYFEVAYCSVDECHKITEFLLKTTEQNIFKLRSVEMKPDDVDRILRSKVRILVLDTCTICKDTVWTPNKSPDFEYEIIHYLQTLNVSSSKLPSDLMQLLLHSFNLENLNISCFEFLPANSSSSMIGLKRKWNCLQIDKYIPSDYLKNLLKEYSVYSLSLNLSDNSLTVDFLAIIDNFKNLKRLNLSASLPLSIYSPSNYRFFATLRDLDVSRNNITSTNFEFLACFTSLRSLNISESKIEKGLFTKMLTVELIASLVSLDLSGVHLEFSDFKRFLPCKKLKCLYFKVANDRSLSYYVDILVFTAIKKSLNVLNVEIDRNISIDDLVSLNGLSNLSEVKIICNAFLLVGEENLIKFDFFNPEFRLELCLRHYNLDMYTIEILKEMFKNYSFSIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Y7</accession>
    <name>A0A4Q9M3Y7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0089p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000089">
        <property type="protein sequence ID" value="TBU20321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Y7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0089p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="14593" checksum="D2EA48096772A5BF" modified="2019-07-31" version="1" fragment="single">MLAMGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Y8</accession>
    <name>A0A4Q9M3Y8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0009p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Y8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="767" mass="88187" checksum="E1D215C39832ADD1" modified="2019-07-31" version="1">MKHEFIKIIYQFKINKYLVEKISMEFLGMKSYRMWFFIIMCYCGKRVNQDSSYEPYEIQVDGITRDTHSTPGLLQSESNSSYELLEDETFPELEEEPYYDIDRFEKQTVTSSPSAAINTEEINRTYVRNGLPIIFEDKEDEEDEKASQVFDLASIPKDFRGLRLNEYFETFGADFRLEQSRMSSSDFLDSLRATKPDSLDSDGSLTPDFLDRQEKIDSTSGSNTNKLEYPLSGHRINRKNWVYPDTCSEDELTTFKAAYYGRYEVDHAASATPLAYEVAQDEMKGVLNNHKSEVSGGRNSISTQFREAAKILSIEDEKSNMIGMPADLVGRNSTTLESKNNYTDETVDNREGKSGSGGKKVKEEAEKFEEIHKTSVKPSYKTEKCIYENQEHQYLSDKNKKGIDTTDSFKIGDNENDSITEAAAGMKKSRNNSISSCSTDPLADLDELTFKVPDYVSDNSMDMSIIKQLLAESIKIIQTFKNIKSLIQNFSMALMTKLIHSDKDILEIISEFMKEINSIYKCEEFIGNTTQYEETLNLVERLAELRKFNEMTNDTLGLSQSENKELSFPSSESKISLLFEPQNVGSQNLDVISLKKGLENTLSEILNLKKKIDQYFSTQQTAPKDEKQNSLLDYHNSSNISEETSNLGLNVTNCNNTRSKNISSNDLSRNIMKNKKNIIKSHMDNHRTTILNPEHDCNRKNDSNEYLRRTEEDLSVEKSNKNHLNMKKIHEKMMMEKELIRLCKPFKSKDLFFSSKKYQRKLAKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M445</accession>
    <name>A0A4Q9M445_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative SH2 domain-containing transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0005p0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M445"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M445"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0130"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt6 SH2" evidence="1">
        <location>
            <begin position="784"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="960" mass="113354" checksum="3C591F75BA0247A2" modified="2019-07-31" version="1">MSDSSEEQIFNRRRISKKHLKTEKKDLENLFNEDEEDITDFVEDDQIEYAEYDKEEMNTIFYEIFGTGDEYMYVLEENEEISAEKNVSESSSESSVEIQEHFDLEEIVQWIQIRKEYPKKELDFFIQSLLENDFVHYILFHSLGVKFGIEEAYEIIDLYNEFKEFIKIKNMLLSKVNADELRNLNKFTKLNEVRDFSKYIFLKEKLSRFYDPCCETDLILSPNDFFENLLNKEKINEIQSENIPLDLFLETKGISKEYFKNYHSERLSILPIFQPFILEYCLKNGKFDEDLIHNLDIAKINDSDVLIVYDFENLLNEISKFYCIGTEDQWNKLRKEIISDVIKKIDIKEIIKSYFIDEIKNKIKKNLFVNVIDRIINGGIERPKYQQHVFGVSNDFKNVKVSVVNHKGESVESKTLGMNQNQDWLELYEKYAPICIGVSGSDYNIKNIFFRLKEIIPDANIILVENDIFKILSSDTSNFCYNIGLRILYPEILIMKMLKSNLFCEFVKNQNYLNNDEIKKQVIRGLLTAMSIVGIDINLVIENKNCHFLLETILGPKKTSKFLKFTNENGFIEKLSVLDDKKIFNSVEFKNISTYFRIFPDLHEFDTENVSDIIDSLSIHPTNYSYAKIFCTNLLKEQEIDDKQTQISLKKFVEDKKEVLDWGLAHVNTDDTTSRAMFYISECILEPKRPIFEGSPDILIFNNLFPLYEKLINKIFEGRVVKVGDAFCIVSVVTENNNFSVFASKSNEVFVNQFLKVKIEDINCSTLSFKGSLFVEEIKKVERLKFIEHSLFKNLNAKEAEKYLIDEKKPLIIRKSSRGNYAVITLKIFKDVFIHLRVDEIIENNKIFYILLGKKYDELDEILSTFIKSLLFNSKMIQEHDKYFDNEFDAQKYLKDSFDGVKVHYCFYFSRKYPGKVVFAYIGPNKILKEEYINLFEQLEFDNRKFNDIDEFLVYRKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4F6</accession>
    <name>A0A4Q9M4F6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0042p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000042">
        <property type="protein sequence ID" value="TBU20632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4F6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0042p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="145" mass="17574" checksum="6DB5EABB4085E97E" modified="2019-07-31" version="1">MEFNAILNHLFHTHFTYIQALLYFRRNTNGLISSNINLNRITTLFIFIARCKLFCFMEIDRFGLIMKRSLKFNVNSEKEVPIIRENILDIFVKRETIYNEMLLCLQKKSLEFHRFELFEFLNGIISRDLGRYENNYKKLKKILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5W1</accession>
    <name>A0A4Q9M5W1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0005p0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000005">
        <property type="protein sequence ID" value="TBU20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5W1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0005p0070"/>
    <dbReference type="OrthoDB" id="2190670at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="263" mass="30875" checksum="0E83D74D3F483DF1" modified="2019-07-31" version="1">MEIECLLENLKEKNFEEKLSILTKITEISKNTDLNILAEYEIDNILLQIFKDSNTTQRIDLYKILNSLFLLVNDPTIFLEIIKKDFVSNNDSSLYAAMSLYFLMSTYNINYSEFYKLFYQIISPTTIKKDIETVLCFVKTILSTSIPTLKCVQAYIKKLCSLCLLLPTSDTISILHTVYVIMRIHPITLKMCLSESIDYKLLYCLDISFDTFQPYLFEFDILYFSIPPVKKIISIIRNECRKKTKKYEIEFLLNEKCPYCINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW76</accession>
    <name>A0A4V2JW76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2522p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002522">
        <property type="protein sequence ID" value="TBU06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2522p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18957" checksum="3340D424647C6BBA" modified="2019-07-31" version="1">MLNILNDLLFLIDKTYISNIIIKIDTLIDTFTNPDMNEYPLITFREIIVDLDLLIKKQFIILYIRILNFFRSKNIFHEESQSGEKEFINYIIQTLEIFSKSDGDILRLHSKHAKKEYFYDINTLLLLGSCLIKRIFRNRFGIVCCFNLNDHFQDFFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXD6</accession>
    <name>A0A4V2JXD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1230p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001230">
        <property type="protein sequence ID" value="TBU11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1230p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020248235" evidence="2">
        <location>
            <begin position="18"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="410" mass="48436" checksum="AAFDDD4E6C91CCC8" modified="2019-07-31" version="1">MKRILVLFTFLLPDILSIQTTEMNTTYCLRKDQIGKKFRLNNAFRMKREYNELQVIKAKLKENNELNILIKKSEINLRKIQKLLNNTNQIISDIEESKRSDSYIHKSKIEKKEILRIKNEIFRLRREKTGILGDFKRYICLKIENTEKIIFYSNYFIRNENFISKFGNQDMSFIETLRNKQKYFISEFENDSKTLNFIVTELENQNFIKTEDLNQIKSSENNKESCDEIEKNNFIERDTGNNIECCDEIEKKDIFISRDTGKNKESCDEIEKKDIINHDIPNKNMKNTQDSSGIEVSSEGNNFISEENNISSYSQPEIQYFCSTPKKNTKNFDNFILKNNFLNPKSSSIHKKTSPQHTETFSDDISFSYLNPSDSICYRNNSEDDSYGSRCYEETIVDYPFPLTNRRNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXL4</accession>
    <name>A0A4V2JXL4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0815p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000815">
        <property type="protein sequence ID" value="TBU12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXL4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXL4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0815p0020"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="201" mass="23421" checksum="15439DE14A29AC4B" modified="2019-07-31" version="1">MNTFLIYSLLIFTMTQAMIVFDLNGVLMKRLNKAKSKEIKEIETNNVMRDITLNSSVVFLRPNFEELILFLRKHKARYIGWTTAISSTVEELKLHLKGWGFEFEDILSQEYCDVGGVRPPDIKSEKWIKNLNIVAEKYKCSLKDCVLVDDSRNKSVEGQNFINVAEYNPLSNKEDQYLKELCVALHDYVQCNDDDCEYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXW6</accession>
    <name>A0A4V2JXW6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0453p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000453">
        <property type="protein sequence ID" value="TBU13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXW6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXW6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0453p0030"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="488" mass="57417" checksum="EFE2BF2101B8CF47" modified="2019-07-31" version="1">MKISKKMLTKSEKIIFKKIRKFVTNTGINVIPRVAGGWVRDKLFGNNSNDIDIAVDTMSGYEFATKLKDYYSEDLFFSRIGKIKENPEQSKHLETAVMKINCIFVDFVCLRSELYMDSRIPQIKIGTPKDDALRRDLTINSLFYNLMTQEIEDFTEKGIQDLKNKIIRTPLCPLITFRDDPLRILRIMRFAARFNFKIVPEIKIALQNKEIHDALLTKISIERIQIEINKIINFKRSSMVFLWVFKYNLYNSIFKDDTVYDNKKAKLFIKIISQIKSIFVLPVKKIKSTKKNNSYRIQDKDLDLKDVLEHHHPANCVILNIYKGIFLNIRVIVQSKKPTFKNYLICKENLKFPNKFCDLIQKIEENFLFLEKNIAIFDLTILNCIILIRKMKNSWLETFLLFISIQKLNENVVLEEKAVLFLSFICKNNLCHCYDIIPLVRGKDVGRLTNDKTKYSVLLEKAIEHQILHKSKSKREILEYLRSELNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY66</accession>
    <name>A0A4V2JY66_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0181p0060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000181">
        <property type="protein sequence ID" value="TBU19883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4V2JY66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0181p0060"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1721"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1998"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU19883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="2029" mass="242238" checksum="0268C797F400826E" modified="2019-07-31" version="1" fragment="single">KFFIILNFLYSDSKIPEKDYISIREFNFVDICRFLPYILNILYNNAFFITFVDNIFLKSNTEHLVNSLFDLIDLESTNKSIPFENVIQTELYCDFKSRLTWLFRLYRKVIIHISDSELYDEHERLISLFLKKACFIVKNFYRYDFTFVDFINKNIIKILTKMNAKNVSEFEVTTLEILFDYCIRKRMCFTVTACKNVLYLGILITSSRFYNNFPCFIQELLDLYLKSLEFSIFLNIFPRISTCIQSNAVNFLKYHREFIINFDQIIDNLSLKEACENTELNVYVNLIKHCRKSLQTIETHIFFLKKNDKNTLKRLFYDEFRLFFYLKFIYNILWLKNIVLKAEIKYNLHRLINIPKKCYKKENIHLFKFINRLALCKINPMFSFSLYMTETTTYDISEFQTQILNACYTHNINMLSTHEFLFEMMMGLEYISTDLYYVFSHTDITSKFNLVKKHIELVSLIYEKIVSIYTPKWIQYNSLEVTVNDLLSHYDTIYSSEKNFIESLKEHIYVLIYQNIMFLEQMPFIMHSNNPTEYISYIDLLHKISLFTTDYDPNILFIYYKYIKCLSIEIFELKLDNLIYLLKFYTQQLNKIPRKSPLEFYTDNNIVYLIILKFLMNMNNLKTDLIDFNLPKILNLMIENVCLFSEYYSHIFLQHIPLLKNIEKSISKLHMFIKISDLILLIENQLMNPNSQAQALEITESRYLYFFLIGCFENFYYLDFFIEAQKKFDYFFLFIFNQVNRITNPKKHFHKKPNSVLEYLKILKTNINTNIENNKNMIYNKESLLFSDIVNVSNDPKEVLLYLISLIRLANYSKQISKIDIYHYFKTEIGFKYCESIIGNVLNTKNQILEYAYTCLRNLFEDEFYLISSFAYVLDSYTKLPKNIFEYFNQKMVYKSEVCINYDNFSSLITEDDMKLKIEILQDMIMIIAQEQHSYRIITLQFLSEIISTFPSLLHFIEKETIDEFLNNFISNKIFDDFISLNNSFRWSLDFRYGYFITVTLYRGDLCYVEYVIEKICVLAKIKDFDYSYNLFSLIYKILLSEICCCKYIQYLNTINHDFYDENCRFNFEKRKKEIYHIFLSNGILETLVNKFEQNLCSSSHIIMLHNCLLKLLNIFLSYINCGNIKFLEKYLMSSIFQCYLPSLYNIFCHISFSLINDFNIYEISFLENSDSLEYINISRNELTNLKNIDFGYIMKYHIGIGDFSDYKKIIFSNSEIDSKIVNFYAENINDIKTVIGISIWKNSDEQIYDNLKNKLKRYNLSEDVHEMIYSRLILSEERADFRKFDKKKIEWVFKYEDFIREKYVSKICKKASLDEKNKDGCLSTYTSSNLDVKTVCNKLLCDLYILPVKECAFELIEIIKNLILLDVNKTFDEDFLKYYCTQVSRLNSRTQDSYFNENPLKFVCDKMQSYSDDSVLELLLFESLYLHVNTDRLPIDSIKLKNAQDSLTSNASKSKNVSQNILYQILCNQKKIIDSHLTLFNIYLYYCDKIGFLLLKGYFAEDETILRAKSIFCKYDRFLNSFDLASIPFKQNDIDYIYKSLEYIATSPLFIFFRDFNSYKNETIVFLFKKYLEIIAKCCQVYSYVRNRIPNDIDLIEYTNKFIFHDFMSFIFGISNKIYFPNSEQIYDLISFYLKVKTIFHDNFDLLSSFKYISLETKIMFLTRPTYFSDSVAYSAFYLLINPKNIIESTINFFETKSTEEILCENWMAKFTTEYGEGIGPLYEFFLLYSKAINENIYFMPFRTNDPVSIFALSDTEEHNKIQKIYYYTGIIMAKSIIMNSVMGLEFIESFYLFLAQEKFCIEDFKNIDREFYENYVSLRDVEDVDSLDLDFTVLAAVNGELKMFCLSEDGYSKRLTKENVEDYIQKNTEFKIYKGMKDYLDKLKEGFNLIFPNTLHNFFSYDDLKIMVEDKKELNITEWKSNTKYSGVYYSEHPTIIWFWNLLTGFDDSERHKVLKFITGLDKLPTGGFKSYKFIENPFTIVPIFSKDSLPSASTCFNLLNLPLYDNEDSLKEKMRTAITVDYYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA3</accession>
    <name>A0A4V2JYA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain fatty acid CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0085p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000085">
        <property type="protein sequence ID" value="TBU20353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0085p0030"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020692617" evidence="3">
        <location>
            <begin position="20"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="653" mass="76906" checksum="CE444F3D16C7170E" modified="2019-07-31" version="1">MDMLFYFILLFQIHDGTLSSRTQACEFHDDRIIFKDGYYEYDTSRINPKKKLRELDSIVHLFEKAFKFNENNVFGIIVDEKINWYSANVLFWKVNDISLFLSKKTDYESRIVGIYSENRYEWLLIEQAVYRSNKIFCPIYTKFNREAIHHVLNETDMKVCFISKSQAKRFYDDILSLYEIKLEHVIFLDRIDDDLAKKIRLKNIKIDYLDDIQRIELPINISRCFPTLEDIAMYCYTSGTSGFPKGVKQTHKNILKNIESYVYATNDNMIYKFHEYTIYLSYLPLAHVMEHMICYYLMISNSKIVFIDYDYYDLHTALRIVQPTVFVAVPRVLEKIYNRINQELNSKNAITRHIFRKCLNVKINNQQRKIYKHSIYDYFIFREIKMIFGGRIESIMCGSAPLRKDISMFLQAIFSIPIIEGYGLTESTGVCIMSPINNPRLGTIGVPLPGTKIKLLPTDDHDGFKSGELSLKADFISIGYFKNESLDAELFSPDSWFATGDIATVYGSYFQIIGRVKEMFKNSLGEYITPEFIEKNLKIPIIDDILITGKSTYSYIIALVVCLKHEITPEYIYNEIREKGEEMKKRNILFEFQIPKKIYVLRNTFESFRDFITPTVKKRRIIIEKYFAQQIDRIYNQDILYDGATIPVNLWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L1H6</accession>
    <name>A0A4Q9L1H6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0766p0040</name>
        <name evidence="9" type="ORF">CWI38_1125p0010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="PITJ01000766">
        <property type="protein sequence ID" value="TBU01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001125">
        <property type="protein sequence ID" value="TBU11590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L1H6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L1H6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0766p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1125p0010"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="142" mass="16913" checksum="8440BF77E07C3E77" modified="2019-07-31" version="1">MWIRKKSRKYNKYYFYNEDTGESIWKHPKTNFKIYHILIKHENSRKPNNDYTYEMAVEKINEIINILEENRNILDFLSFFMKIAEENSMCSSFKRGGYLGTICKNEMLKEFEDVALSLGEDEFKGPVSTDSGLHIIYRSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L6W5</accession>
    <name>A0A4Q9L6W5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalytic subunit of chitin synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0306p0010</name>
        <name evidence="2" type="ORF">CWI37_0518p0020</name>
        <name evidence="4" type="ORF">CWI38_0114p0040</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000518">
        <property type="protein sequence ID" value="TBU02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000306">
        <property type="protein sequence ID" value="TBU03368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000114">
        <property type="protein sequence ID" value="TBU20200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L6W5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L6W5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0306p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0518p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0114p0040"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="277" mass="31275" checksum="EC7A50E157E0ED52" modified="2019-07-31" version="1">MDILNLNHTCSEINLPLCKVLKDTPCGYTGRSLPVFGTNLNTFFTIIILLAAMFCTFRMIKGANKKYSAVGRKEMVTFFYMYLATISLETVLVSGVLKKNVLVYLTSLQLSFANSTVFCLFIGGLTSTSLVDIGLLKSILIVRVLTFVYFVTSIVVIYMFLVAKNSFIICFFTFILNLGLAFLYLILQVLKLIRLDAEVWAYGTLIISALFFMSGILPLFFGSEYIALLSDRYLDGLFFFHLFIFCGIIMIHKYWLSVCENEAECISLIVKGEIKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L7W2</accession>
    <name>A0A4Q9L7W2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0416p0030</name>
        <name evidence="3" type="ORF">CWI38_0711p0050</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000416">
        <property type="protein sequence ID" value="TBU02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000711">
        <property type="protein sequence ID" value="TBU12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L7W2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0416p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0711p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="114" mass="12938" checksum="FA9F21486DF7FD4F" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKREEDGVKILKPKNNTPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L953</accession>
    <name>A0A4Q9L953_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit beta of proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI37_0178p0030</name>
        <name evidence="5" type="ORF">CWI38_0506p0020</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000178">
        <property type="protein sequence ID" value="TBU04144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000506">
        <property type="protein sequence ID" value="TBU13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L953"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L953"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0178p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0506p0020"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU04144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="268" mass="30854" checksum="9AB219166B0C85E5" modified="2019-07-31" version="1">MKLYNIYDESFLKKKLEGLLTKMEIKKDLKIKENIFLSNNILQSSEEQETLKESSNGRFNPYENNSGTTLCIKQSGYIIAACDTRHSGEMNINSREMTKIYSIGDFILTTTGFYADSYELSIRLKYQINMYEVQHNKKITIHSAAHLLCNILYSKRFFPYFTFCCLCGFENKIPYIYSYDPVGSYQECSCRCNGSGAGMIQPLLDSLISKKNWNNCTIQDLNDEDGLKLVQKAFEAASERDVKTGDFLEVYIIKEGEIQKSVFPLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L962</accession>
    <name>A0A4Q9L962_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS_1-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0233p0020</name>
        <name evidence="9" type="ORF">CWI38_0014p0020</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000233">
        <property type="protein sequence ID" value="TBU03785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L962"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0233p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0020"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="12"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="441" mass="50887" checksum="B6ABDCA1C0358842" modified="2019-07-31" version="1">MSILEKYLVLPKLLYFILSLHIYTLHSYRGLFAKKMFGIDEGLYGKVNGILMLIAFFSNIAIGNLIDWFHQPVIISILMLIGSTICFLLFFIVKSILQFWMCFFVYVLFCSGLVPIIDRIILEFLSQHNYSSEVYGKQRMFGTLGYVVACYSVEKLVGGNDILEFSNLRIYLIGVTVLAVSISFCFYKRKTPFIEVKKKERKNTGIIDLLKTKSYMFFIGIIFFIGLGRSVMTLYLTTYLSKVLKIRGFECKNSWWFWKFINENPMATLAFFGVSVEVLILFFLKYISKIGLYWPLLIAGIAQMIRFIGYYFLKNGKMAFLWCCGIESMKGINFGLTHSSGVRLANSLCPEHLKSTSQMIYSGSFGGLASVIAGWVFGNMFDEINADTPERITEFKTIFLINAFLCVVFSFLFIFKYGIIDKKLKLWCFQKKYIDIEEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LBD7</accession>
    <name>A0A4Q9LBD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tubulin binding cofactor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0045p0040</name>
        <name evidence="4" type="ORF">CWI38_0021p0100</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000045">
        <property type="protein sequence ID" value="TBU05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LBD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0045p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0100"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="192" mass="23043" checksum="2A9A91FE8A66D4B2" modified="2019-07-31" version="1">MEENKFNEYLNSGDSENCKLLIQKLETKLLNEKVEYSRKILKEKILKFKTSYKSLSKEIEICLEKNKREFFKIENNFQNKLNNKIYISSLKDLEYQINNCEEVCIENCENVEFTFFRVKGSIFIKNCINCKFKCISHQIRLYRCVRIYLEIYVTTGVFIEESQDICTEQLFVQGMETKNNLYNRIFDFSNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LEC0</accession>
    <name>A0A4Q9LEC0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2595p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002595">
        <property type="protein sequence ID" value="TBU06339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LEC0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2595p0010"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="11134" checksum="500DB936B058F5D0" modified="2019-07-31" version="1" fragment="single">SHSVQEILYKEYAELRKYDLLANKLGLIYNFSVEIILYVMDRDSIVTKYHKKYLKRLQIPMNVEAYIQFIESRESASFNVILGAETHKQPTTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LHD4</accession>
    <name>A0A4Q9LHD4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_2409p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002409">
        <property type="protein sequence ID" value="TBU07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LHD4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LHD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2409p0010"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="195"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU07377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="600" mass="67957" checksum="36B872C34A5D3DDB" modified="2019-07-31" version="1" fragment="single">MKISPTFKKHISTFYPLNTDISIHINTIYSILTDDLPNKHLRIEQYISQPITLSVYTTLYNLAQENLTHTKSQNILSHNKFDSSSNERSNSNFIPKNPNNYLYPTINSNNSLKPNISLNPTINSNNSLNKTIKLPPNSTIFPSKNYLSIKIPPNPTKIEQPNPILTDSNSSQLLNLLYQVMPSSFSLTQLQKSVIPSVLSNRNSLFISPTSTGKTIVLLLFLLQEHISLTNGNKDSNSNKDSNSNSDRDCDGNKYSNSTNTNPYINPNVNPNINTNPTNKNPCINPNTNTKNPYITNNNTTFVLVAPFKALIHQHYKFFSKICNKIGVRVIEITTDSDINNTNIFNSYNYNKTHRNNNTFYSNSSSNSNPFISSNTCIKRNNNIKEVDQCINRTDKDYIADREGFSNREYITNPNPNKCINTFNTNTSSNSNPTPNKCINTFNTNTRSNPTPNPNKCINNTNPYTNPTSNPNKCINTSTLIITTPEKLEILTRNKNIFYNLLLIDEIHIISSKRGVYLESIISRLIYNGISRIVGVSATVSNWKDFCNFLRVEKKDCYVYDERYRPIKIGYEFVETKGVNNSIDDYRGVSDKSSNIKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJS1</accession>
    <name>A0A4Q9LJS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin head-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_2257p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002257">
        <property type="protein sequence ID" value="TBU08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LJS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2257p0010"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115788" checksum="0849934982140B01" modified="2019-07-31" version="1" fragment="single">MQIEDLCKLPLLTEEKIVEILKERYDSGLIYTYSGIVLLSVNPLKEIDIYNKNVMLLYSGRSNGYEGVSRDMLEGDNYRYSKLDGDIDSRDMLEGDIGSTDTYHPLNNSTDKQHPLNKSTDTYHPFSNSTDIYHPLNNSTDKQHPFNNCTDKQHPFNNSTDTYHPLNNCTDKQHPLKNSTDTYHPFNHNLYKQHPFTNTTTIPHTNTLSSFEPHIYSIAEHAYQDMLFTPHQTIVVSGESGSGKTVNTHYIIEYLINKESNKYGGVSKEYDNYKGVSKEYDNYKGVSISTNDYNPVNHVSNSTNTYNPVNNTNISTNTYNPVNHVSNSTNTYNPVNNTNMTTNMTTNITTNITTSPYIHLTNISKSPINNISYLKYVTPLLESFGNAKTTLNTNSSRYGKLITLYYKNNNNSYDIPILTPLYSSIKTYLLEKSRVTHQQPLESNFHIMYQVLNYKKLYIKNDYIDNTSDSISVSKDGVRDSVSSRDSVKVSKDSSSRVSSNTNNHTTHTTNNNTSSYHDYTNTLYSLKVLEFPFIEELEDLLLCIIALGSIKFIEEENRVIITNGSYFRSSEGDSTSEGVSTSEGVSTSEGVSTSEGVNSSEGVNSSGVNSNNNNHTSNNNNHTDNNHTNNTNTTINNPLHFIYNTLKITPSILKEYLLIKKIKNKNEIIIINNSIDNAKSLRDSLARNLYSMVFEYIVRYINSKLRGTSDIGGMVGGVNDKDSSYKDMKGVSNMSSNYKGDNTSSYKQQGVNNNTNTLHPFNNHTTQHPFNNTPNITSISILDIYGFEVFKNNTFDQFCINWANEKIQDEYIISLFKEKQALYESEGIKWYNSDICMKGDSSMKGDSSIEGDSSMKGDKSYSSTTNTPLNNSTNNNTLPITINPNTLSTNTNTCIDLIESKYGIANLINEESINTIGSINGLYNKIYKYNNNNKSLIKNKKDNTVIVKHYACPVEYELKGFIEKNREKCCRGVICSINNRFIREIRDSNSSRDVGGVSNSSMDVGGVSNSSMDVGGVSNSSRDVGGVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LLG1</accession>
    <name>A0A4Q9LLG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2278p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002278">
        <property type="protein sequence ID" value="TBU08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LLG1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LLG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2278p0010"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="973" mass="113379" checksum="0D39752E54794186" modified="2019-07-31" version="1">MVEKEAYKALQLIKERLSHKKTNKSKIKDLIPYNSQRVFKFDQPILQEPNQEKKENFEKVDSVLLTAIDTLLRHSNVTNFSEFLRSFSFKKPVPTLKSLTEQISSPNYTLAGKYLGHFTQISCMCQDENSTFVFTGSEDGNIKMWNIKTGISLNVFLLHKHTINDMCVSQDSQFLASCDSSGRVVVWSLKTYKPLYNMEMESEIEFVQFIRKEEDIRIINSSYSDKNISQDTVNSTYNTYILCLVFSSGVIKTITFDNETTIATTQNTSLMDISLENSLRAVCVTEGYRFLLCGGTFPFLLIFDLTIPENFIVFETGGFTISSVCASRQNLKFAVSTHFDSIIQYTFIPSGTPIQGNFKKKRKEIQGHWKKNIIHITSESYCDRLCYLSDDTKLVGLFIDNSIRLYHNNILTATYYLSSFSSILTASNNNTIAVCDGMNLLVLNQTLSPVYTDTLSFRPVDCLFNKENLVLSDEFGYIVIYSICPFLKIYKKQSLQQFFECEFLNRNLEIEEDFIECNGDPIYDINKNTKILENNFSLKDVLTNKTNNIFQIKNERENKNEKPENIEEFMDIEMTKKSKNLMVGNSYQMYLENMAFEHLKDDFITPTQFKKKYLFTNETQEETNNSESTCLTESSITSDDNIISESTLDEESYVSEITDSTYSKESDIIITTERIVSETFNIELEKYVENWLLGNTDFQSFLPQIGDKLYFFSEKYKEFRNYELREEFNCEFDNLNNLEDLEDCIVEIKDVQIIKYDPSYLQVECIKTEAEDLNRNKRIKNGNEFNKKTFFIKYYDYPNGGNIFLLKAVFDTLNEFKFRRNTVVSVVYDGILYTGKVLRVERDGAIVLYDDGTEEWVGRYDMYCNYTSYGGYIATEMLDGLLSIIGNFGDVRALFVKSKRKEYLERCFYFVTLNLIKKRILNGFYRSIESILWDFDNLYDNSIYLDESVVKRCEEILKEVYSLFGKNFRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMY6</accession>
    <name>A0A4Q9LMY6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2119p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002119">
        <property type="protein sequence ID" value="TBU09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2119p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="159" mass="18147" checksum="58213132245B3BFE" modified="2019-07-31" version="1" fragment="single">MDQILFFEIVTENRIRVLNGGELKEYETQEYLNGDLKSVTNNFLMVITPFCIANSYVLKTIDHILTNTKILGVAIFFPSTLSSFCFETHTILFLTVNMVHKDEIKEEELSFTDNVTSPVHTQELIKKKIESENKVNCNVEIIINTSFSPTYSQNVSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNS7</accession>
    <name>A0A4Q9LNS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2253p0010</name>
        <name evidence="3" type="ORF">CWI38_0077p0010</name>
        <name evidence="2" type="ORF">CWI38_2049p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002253">
        <property type="protein sequence ID" value="TBT97462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002049">
        <property type="protein sequence ID" value="TBU10068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000077">
        <property type="protein sequence ID" value="TBU20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2253p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0077p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2049p0010"/>
    <dbReference type="OrthoDB" id="277458at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="222" mass="26256" checksum="1A74929909CAFC2C" modified="2019-07-31" version="1">MLGVYFPISLFLLSYILYSSYSNHFLGLEKIENLTINKIDAKISECNIKIKSEKLLLIAEENSMWLSIERNKFITIENSGEYNKIFIFKLIIYIDKLLKINKKIIFLLEFLNKKSETMNIKNLISYLENNQIYNNEYLKETNQNIKSIIVSIKNLNLQLLNEFTEISKNVNTHDKKEYDKKHTKNSIYIAKLINKLSSILSYINCLTNYENNIVMNIYYMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP13</accession>
    <name>A0A4Q9LP13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1953p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001953">
        <property type="protein sequence ID" value="TBU10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1953p0010"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27322" checksum="8731759E312F00A4" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQKEKIIKAANRASEEDGVIRECKNDQGIPQPSSYTPSTIINNISIPPSEANTNTKVCLLNTITRHLTLCIQAPWPNLCNIPISERLVVLRSILRSIEAERQEFIRCVLFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETIDVLKRMAHNKTEEEIRQEENGERRRIATCLAEPCSLTDATRFISLREKYLSNIKKISEEEIGKVVVRTRKLPNELVDTTVLDLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPE2</accession>
    <name>A0A4Q9LPE2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1875p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001875">
        <property type="protein sequence ID" value="TBU10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPE2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1875p0010"/>
    <dbReference type="OrthoDB" id="10432735at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020983741" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="184" mass="19666" checksum="8016D5E940F00396" modified="2019-07-31" version="1">MLFFIATLPLIFLGMCYSQDGETDAKTETNNTDIARPLVCENATIIEISEEDKKVLGQNPGETDIAREARLNGLVPVSVYTIFANPLKSGQYQSLPSTLSALSSSMFHMAANGSTEKNGQNFNFIKGMIETTVKPSDNKTNEKPPAEEGGEEGEGEEGGEGGAAAPEQTSGLKPKKKGSKLKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPG2</accession>
    <name>A0A4Q9LPG2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1853p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001853">
        <property type="protein sequence ID" value="TBU10318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPG2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1853p0030"/>
    <dbReference type="OrthoDB" id="2190279at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32881" checksum="8F5665C5F6466180" modified="2019-07-31" version="1" fragment="single">VSKLKQELTLPHTKTVILHCGKQAIKSFNGVPVFFVSFYRKNFIFFQISPYKEIKSIVYLEEFKNYTFFNDKICVLKDNSVEHLDGEKMLEGDFSQFTDIYMINDNIVLSGNKYLKIFEICRNNSENEKKVFSVENIHSYFIKCDCFFIGYAVTLIGRKNLIDIKKENQLLGTLTFPENITSVISDTLVTKVYSGSESGKIYFSSLEDNNCLEHILYFHESSIIQLKMSFCEKFLYSLDSNGKIAVWNTEYNNFLGFNNFEAESMLVCCENEVGDFQNEDFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPN9</accession>
    <name>A0A4Q9LPN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small subunit of DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2160p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002160">
        <property type="protein sequence ID" value="TBU09330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPN9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2160p0020"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="231" mass="26624" checksum="BDF38307C28BA78B" modified="2019-07-31" version="1" fragment="single">TKILSTVPVKIDFGAVYANRLRKGTKCIPVEKELVFDIDLTDYKRICCTGRNTCETCFVLVKSAIKLLNYSLKEEFGFEKVLFVFSGGRGIHCWVSDDNARSLNNSERQSVTKFFDSVSKRKIFPTEYCNILMENISYFNEQDLNIKPETATVEEIFEHLYIKLDKNVTSEIKHLLKSPFCVHSSTTKVCVPLDPENIDTVLIEHLPTLQNVMDNPKTLDPYIRIFDQIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQL6</accession>
    <name>A0A4Q9LQL6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1549p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="PITK01001549">
        <property type="protein sequence ID" value="TBU10789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQL6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1549p0010"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="246" mass="28146" checksum="7110B2C51D573EF6" modified="2019-07-31" version="1" fragment="single">LLTIFKINGTPKSRKYIFLGDYVDRGANGLECFCLLLVYKIMYPSNIFLIRGNHESKDLTKIYGFYDEVAKKYGNSRVWRYCCDVFECLINACLVNGRIFCVHGGLSPSLLDIDEINRIYRLNKLPDNHFVNDLMWSDPDELNPGFSKNSRGAGYTFGSEVTKKFLEINNLTMLVRSHQLAFTGYQMHFKEKCAVTVWSAPNYCYRCGNLASVLRVDENDITGKNFLIFKDTPQKPSSVGLPGYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR23</accession>
    <name>A0A4Q9LR23_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1601p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001601">
        <property type="protein sequence ID" value="TBU10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1601p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="415" mass="49015" checksum="B0A0503DADBEC1F3" modified="2019-07-31" version="1">MKQFFSFIDGSIYKNSLESILTDIISTDSEICNDLNTFKSLKHLYLAYNRFEKHMPFVFTQIPKFLQELRLRNMEITSENLESVLNSNIVTLLFDNCIFSNIVFKERFKYSIFKKCKNFYVSDCQYDLFFLRLLWGFSCLEIISIVNAKYVSEMPVPNRRNTFLKKIKHFNIPNVEESLTSCFFKNLKFSRSLEYLNASVYLSLENDFCKLIESNIFNSIEEICIHSNEGNRFIFDRLLTLNQLKTLDLRFLSIPNKSLIELYRSKLIETIQTLKIGDYTFDIEEYDIFCKMPKLVNLVFYKVSFDSNFKLIFGLISPDRIIGSIHIEYCSLSEDDLRYISKLKISSLILIHTQKNLLQIYYNLIEGVIKDTLVMLKIYDETETNVAAVNLYLAKFVKLEIFIVNDQKYDLYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR27</accession>
    <name>A0A4Q9LR27_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1463p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001463">
        <property type="protein sequence ID" value="TBU10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR27"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1463p0030"/>
    <dbReference type="OrthoDB" id="2188863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020769648" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="23561" checksum="509C2462CDFABE2D" modified="2019-07-31" version="1">MYRFIYFIFQFFGFCFSISSELQKIPIFEIKNLSDTSPTLLYIYFERPDYKCPYCDIYSDYISKLNFPGTKRLNYFDNPFLASKFLVFRFPALIIYFKENCYFIEIKSYEELERIISNSEWLNYNPVNSFINPNSLFSLIFSYSMWLFFLIFKKIIFFIDLIPTVVFSIFFGILGGYVAYTTIKIFKEDEVAVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR61</accession>
    <name>A0A4Q9LR61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2013p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002013">
        <property type="protein sequence ID" value="TBU10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2013p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="11347" checksum="ADC29AEC746D04EE" modified="2019-07-31" version="1">MIKLGTIMAVRVSHYRYYDGKEVFTTNIVCSIENLENVNQLHNKFLYYKTTIEKRLPHKYKTYNFSYFQKFDLDDPKICRQHCIEKNLSGRQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRB2</accession>
    <name>A0A4Q9LRB2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1420p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001420">
        <property type="protein sequence ID" value="TBU11038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1420p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="219" mass="25813" checksum="1C1C7F05964509D0" modified="2019-07-31" version="1">MYVNIKNNNLLLCISDLPSNFPDTLLEEILKLFGKYQHYKRPADVNGSSCNFCFVLYFNIDSVIKCIKIIETVDIGGLKLKAHHDDLNNILNIISNISSNNTILDENTNIYRKAADIDTQDLKRINKRISEIFSVYFRIIERDKTIRNFIEENCIKNEKSISIKKSNLVNLENEWLKEEQEIRNKCIWTIQNQPTKKIKEIEEENYNYYLTYDDDNTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRP0</accession>
    <name>A0A4Q9LRP0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1977p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001977">
        <property type="protein sequence ID" value="TBU10160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRP0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1977p0010"/>
    <dbReference type="OrthoDB" id="2194154at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="46179" checksum="95F4C69E4B3DAC84" modified="2019-07-31" version="1" fragment="single">HSVEFKSEHMLLQLLDCLEKSKETSTRRAAILKVENDNKTHLALIKDFLQVKYGMAEEVTKNKLDEAQLANLYNEIEKRKLHSKLYNARNNELVSVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWGAEGVCQHCNTSRKTVDHLATRCEKMLGHDFTRRHNEVVRCIHLPLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETDKLRKYDLLANELGLIYKYGIVTKYHKTYLKRLQIPINVEAYIQSIVLKKTVEMISFDRRRGIESGPSAEESWERASLSVIIGAKMHKQPTPPLKEVKNEEDSVKQVNSKNILPLILDDVTRPEEPTIDINDKSDVEKENKVVKVMEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRR7</accession>
    <name>A0A4Q9LRR7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1309p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001309">
        <property type="protein sequence ID" value="TBU11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRR7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRR7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1309p0010"/>
    <dbReference type="OrthoDB" id="2141921at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF122">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="24697" checksum="9E56A25BE395F564" modified="2019-07-31" version="1" fragment="single">MNVEWKNLNIELINKNKSIDKKYIKLVQNAYGEAKVGELCAIMGPSGSGKTTLLKALAGRIPDGSRTSGVITCNKSERKQSDWINNVAFVDQDDCCFDDLTIRQTITYSAKFRLKNTNIKVKDKVDAILTSLDLTKVADNRTKSISGGERKRTMIGVELVTDPKIILLDEPTSGLDSSYALDIIKLFKKIAEKNNVTIIFTIHQPSYEMFLLFDRLILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRW2</accession>
    <name>A0A4Q9LRW2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibronectin-binding protein A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_1282p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001282">
        <property type="protein sequence ID" value="TBU11288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRW2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRW2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1282p0020"/>
    <dbReference type="OrthoDB" id="2187858at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="694"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="879"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="537"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="814"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU11288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1154" mass="135449" checksum="D50994EEB43AF801" modified="2019-07-31" version="1">MKQKFTFLDISTIVNELSETLPTQYITNVHSSKTKTFYISLSSKKILLIQPGTRIHLSDERDQEINHFTVVLRKHLRRKKIRSVVQHTHDRVIIIECYDNKSVIFVVIEMFSQGNILLLDTENTIIALYRIVRDMNVKRGEKYSFNDVSMTYTYEMYKILGKKDFLSFDKILSEYILKNSESGETNNNLENKQSEENKINIESENKQSEENKINIESENIKKTDENNKIKENENIKKIDENNDIIENENIIESKKCNKSKENESKNIELDVTPLTDSNGDKVVNPCPPSFFNNSKFFTSFFTDLLKKITSLKNKGYIYLKNNKPDSFLPVLIPTLPHISFDSYNTAIDCFFKVSLNKNIKIKELENLEKLKNLSINTLPSQNIELGKLEKLEKLEKGGKLENEENEGKNLMSSNSIKNKENNKENKEENTKISKIIINYDKRLNLLKETHKNILCTIYVFLENQNIIEEALVVCNRVIENKIDWNEFLRFKEEEDLKGNKVSKCIKSVDFKKKEVTFTVEGSRNIKNKIENKNKIENKNIKDNVRNSNIEIKNIRNKKIENRNIRNIKDNIENKNIENKNIENKNIENKKIENKNIINIKNDTDETYNEEIIEDNELVDYTATFDILVSFQKNISNQYDKIRKIKEKIEKSENSYESVIKKVTKRFEKANISTKKDKKRVVAVQQPSKLLWFRKFHFFFTKNHFLVLGGKNSSQNETLVKKYLEKNDFYFHGDIQGSASVILKSKIPKNIFKISKIDFENEKINKNKETEFEKLNKEFDFEKINENKEFEFFKERMEKINNSNEMEKINNSMKNKELNNSMKNKNKELNDLNENEMEKINNSIKNKELNNSNENEMEKINNSNEIKETKKPLNEDIEDGNNSYLLKDFSNEQIIEKPEEIDISQAADLTLCMSKCWENNVIGGVYYVSEEQVSKSCESGEYVTKGGFIVRGKKNYVTTFRLEMGVGIYFKLKNNLKNEEIIFTEKINENEKKIKENKKIKENKKNKENKENKEGDEMEENKKNKGRDGIKEIGIDEMEENKKNKGRDEIDKNTFKNIQNRNIIRYDDFIFVTSLFGDENVEYCFPYCAPWKSLRNNKFKVRLLPGNVKKGKLIKEVVGKFLGQANEFEKGFIKKVGVEEFMEAIFFGCKIGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS58</accession>
    <name>A0A4Q9LS58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1248p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001248">
        <property type="protein sequence ID" value="TBU11359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1248p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="437"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="598" mass="68153" checksum="C54519636FB4A98B" modified="2019-07-31" version="1" fragment="single">MGRRKEVDSENIKNEKIKAVNNLENSAGEILMCDVDVAMLSERLPPPPTFHDTTHQPPSSSCQTSQVCLVDTIASSSGTNATAFGPTNGMTNLNTDAILEGNRLMVLHSILESVTVVEQEGPRSAILAVQKRFERMPRNGWPATLRYYNEKFSCTLDIDAFKKLAQNEAEKGIRQEENGERRGIATYPTEPCTLTGITEYINLRDKLLSKIKEISQKEIGKAVVRTRKLPSELVDSKVLDLINRIIGDYADSCVPMTITAVARIIQAAQVCYDEATRKEKPRSAWKENIESKISKLVLSKDLLEKARKQEKLSTPETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMYASRKQFRKENRIFELFRGRFYRGLSERVESEHVVSRDEIVSFWSTMWNKNDETVTYDDYLIPFKLTTLHKYLYDIVKVICLEGTPQADWFYCGLTYLIPKEIPQRGSDYRPITCMSNLYKLTTKCVTKVVQFEVERRGLLAENQLGAVRGVQGAKEQALLNIALNKEYDNNLKATWIDVKKAYDSIDHAYLTQCIENLNLPDWILKFIKVIISKWKIDISVGPEKIMSKKIDRGILQGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH6</accession>
    <name>A0A4Q9LSH6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1719p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001719">
        <property type="protein sequence ID" value="TBU10495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH6"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1719p0030"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="7">
        <location>
            <begin position="438"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU10495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="651" mass="75854" checksum="682C29511EB1817F" modified="2019-07-31" version="1">MTTNPFDMETPPHLHTVEERNQAPFNMSFCDNEVSSDASSEKKIFPIHEPFLTKTKEFLLNLNSIKYLKILILAVIFLIGFFFSGNRKVSIKTDSPSENLKLSTVLFFLFKTTISHVFISFVISTTSLYLLQKIDNSTTIFYTHEISNHISLLIILISINAYFFISDKNFYLENKYGIDINLRDMISISIISVILFTTKRIVVKSISHNFNYSNFIDRIKRVLLFEYFINLIENSVKKPKNRSNNSRRSSFLKNLSFLIFKKVHFSSKLLFESKAIEDNIYIKRAILKDFQSTRAPKFFMSDGDKLDSKAKTYASKRENKINICLEQRNHLSINDLSKYFKDKKHYDRFLQIIQLPGETKIKNISLKPILETLYKERYILRKSLFQMSAALGRVNMVLNALIIIFTFAMVFVKTSGKTETVISVLSAMFGTGFVFQSSVKNAIDSLIFLFCIHPFDIGDRVIIELDKILENLVVTELNVFSTVFHRWDGTLIYVPNSVLCEKSISNIRRSGVIAETHLVTISYDTPEHKIKNFKSIIRNFLRLNQDNYNEYFMLNFDTLENTNKLNLKVYMQYKSNYQNYEVYLTRRSKFIALIVNALRYLKIEYKLPRQPVLLENIDNLNNVQIDRRLIKDIRNADGNATDLVNNEPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSQ7</accession>
    <name>A0A4Q9LSQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1269p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001269">
        <property type="protein sequence ID" value="TBU11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSQ7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1269p0020"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="25085" checksum="44C283C7FA962612" modified="2019-07-31" version="1">MEIISEEGFRYDGRKPNELREVAIKNGYLNKCGYIDLQQGGTKVRSILYGPKEKGQYKENIKFKISFYDVARQESGKHEKKIDECETLLSELFKPIISISESNYLEINILIKQDDGSLISTLINSVTILLCYCGVQIKDMCISITSCFFKGISLLDLSNNEENVRIPSLVLGYFPHRKTIGLFQSTGKTDTDSIKKLYFENLKAIDTLFSVFSNFLKNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSS7</accession>
    <name>A0A4Q9LSS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1669p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001669">
        <property type="protein sequence ID" value="TBU10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1669p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20598" checksum="E9B5F0E8C5F92D35" modified="2019-07-31" version="1">MKIALNKQKNKNTETFDSLLKITDEIKKRNVSFVSEIKSDLNKIYEEKNAETISLFQSKDEDLKKIIKKMKKDVELVLKERKDSLKLLKRKVIEINEKLAEEENKEEIINKKLEELKNQIEENFKKNLKSMDNNKNKNLEEIKNHKKQIDKNIEEFGESKDQMSVISKIIASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSZ2</accession>
    <name>A0A4Q9LSZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1129p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001129">
        <property type="protein sequence ID" value="TBU11584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1129p0030"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="394" mass="46893" checksum="627EFC9015939983" modified="2019-07-31" version="1" fragment="single">MEKLLEVFIKEIKESHDVDIVVEWCNKYVKEYYTKESFHYDLINLVKTKNLNEKDKMEILNVCINLFHFGYDITNKVCHNKYTNSDARSINVVSSMVCWGIIGKILMKYFDDEFYIKATEIFDDASFYLCIPNKRNDEMNYFQSKARLHFYTKVYLPLRLRDLIIGTNVTNNYLENEPAFVCKYLVDILKENNIKEENNFNDLISYFGKLRFEEMNSIFKGVSLENLKEDDHLATRCEKMLGYDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETENLRKYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT67</accession>
    <name>A0A4Q9LT67_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1088p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001088">
        <property type="protein sequence ID" value="TBU11674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT67"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1088p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="77" mass="9093" checksum="9C61AED8CAC4D210" modified="2019-07-31" version="1">METFRGLIAKNAVKYEELAYNEEYSSNKVSNKIDILTTISLKYEDKYVPRMENDANVPLFHLNFIPGYVKRLKRYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT84</accession>
    <name>A0A4Q9LT84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1182p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001182">
        <property type="protein sequence ID" value="TBU11487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT84"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1182p0020"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="191"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="384" mass="45317" checksum="8CD72F419B8E4B1B" modified="2019-07-31" version="1">MIGKIKNFQVVQGKFNAEKKHNKNKETPFTSSELLQLMSNLKKTSSKQQNILPVYRHLQCHIENHSQVRKECKNTNACFQIVKREPVDFKYDINKNYLYALIEKIYSCTKIDQENKITVQNIRKNGTMICEKPIKALEFKLQNRLYYSKLSNDEKESLKKYCRYMLREKPKKSCGCIINMIKGFFMGKKRSEVANKKSINPFIYNVGDYILKECIKTEGIFRISGRSSLYKSVPYSLKENCGYKTSDFTIHDNASIFKAYIRDVLNGLVPEFICKELLETFKGSRNAKSIEEIVIYTIFCLDDMERELLSYLKRMFREIENYKDYNKMTMENLVKIFTPTLFPDFKPFDLTMIDKQIDFIKLLFESDFEEVPFDLLNDAHPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW8</accession>
    <name>A0A4Q9LTW8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1325p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PITK01001325">
        <property type="protein sequence ID" value="TBU11201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1325p0010"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="9">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU11201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="195" mass="23030" checksum="38BFC79D88D2E27C" modified="2019-07-31" version="1">MIDDSNQNINELKENIASNNQFVNNAPDKLNFSENKEYINSEEIKEFKSNDIISLESKNITQIKEGVKISKNEKFISKFLNVKIIDFSLSRLNHKGTIIYKDLNEFDWLFEDETIIGEEHLKIYPKMKSNNQNDWKKFSPENNVLWLEYLLFKLQEKGKNFRLVSFFQKAKKILKFSHSAKDVWKAISKIKTCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTX5</accession>
    <name>A0A4Q9LTX5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0904p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000904">
        <property type="protein sequence ID" value="TBU12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTX5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0904p0010"/>
    <dbReference type="OrthoDB" id="2186234at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="136" mass="15361" checksum="4920436DB69DECCF" modified="2019-07-31" version="1">MFINKDSLKNHINETVQIIGKVSRIEPPLIFLNTPEGDIKVTFVNLHKYTKSYICVTGKVQQDLTIQEIHVDHMGDNFDGVNDMTVCIKGVNNKGLKGDNNIVCQERVLMICIKVLNKKVDQQYSIYGGVNDSTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTZ6</accession>
    <name>A0A4Q9LTZ6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0898p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000898">
        <property type="protein sequence ID" value="TBU12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTZ6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0898p0010"/>
    <dbReference type="OrthoDB" id="2193011at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28731" checksum="4E992F4B0FDAB5DC" modified="2019-07-31" version="1" fragment="single">MYIIEFKSEHMLLQLLDYLEKSKETSTRRAAILKVENDNKTHLALIKDFLKVKYGMADVNDSSRWLKKGSVRPRDEAVFCYIQDRNVFWRAEGVCQHCNTSRKTVDHLATRCEKMLGHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFVLDKRRNKITLIEVGITSQDSLQIVETEKLRKYDLLVNELGLIYKCSVEIIPYVITWDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU00</accession>
    <name>A0A4Q9LU00_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1098p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001098">
        <property type="protein sequence ID" value="TBU11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU00"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1098p0030"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6508" checksum="1C8D55426757DECC" modified="2019-07-31" version="1">MGVIMRSEMHEEPIPPLKEAKREEDGGTTLEEPTNNINEESNLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU56</accession>
    <name>A0A4Q9LU56_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1008p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001008">
        <property type="protein sequence ID" value="TBU11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU56"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1008p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="465" mass="55157" checksum="F00D83E8D1CE5FB1" modified="2019-07-31" version="1">MLQNINKFINENYIQKEIHFYILENQIPFRHKTSTDILNNLEEDKNKYFDNNLNPHNNCNIDTITHNNCNIDTVTHNNCNIDTITHNTTHNTDILIVPLNILINKNFYPKNRSHNFYRHFLYPLNIEDVLFLYNSNLNFSIPEFKTYFYLKNNFYNLFRISISDLLLGSKENKDIKENGKDREEYSKDIEENKDIKENGKDREEYSKDIEENKDREVYGKDIEENMKDIEENKDRDENRKDIRNINNSKEYSKNIEENSKDREVYCKDKKHNENIYNTHKSTDNTDTYKNEEKDVFELKKLLDKKLIYQIFKKKADFNRKTENILGILICVSIYDKFINFKKLFEMKTVFVFSCFNPYFYSFLSDNKTLMDFVDYKNNLRDNFVIIRIKKIEGLNKESSGRLVKSVKCNGIRVNNCVSNIGGVNYRSSNIEGVNYIVVMKGVLSICSSESVSNNTITKSVLVAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUJ9</accession>
    <name>A0A4Q9LUJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0987p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000987">
        <property type="protein sequence ID" value="TBU11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0987p0010"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="232" mass="26660" checksum="173C7BDF515F046D" modified="2019-07-31" version="1" fragment="single">KLHSKLYNARKNELVSVSDSSRWCKRGNIRPRNEDRNLLWGSDGMCQHCNKFGKTVDHLATRCEKMLGHDYTRRHNEVSSKRIRSHSVQEILDNEYAVIRITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKLEIQMKVEAYIQSLVLKNTAETISFDRRRGLESGLNAEESWERASMGSAKNFKPKNKAPFISQGGTTLEEPTNNINEESDSEEETIVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUM0</accession>
    <name>A0A4Q9LUM0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0794p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000794">
        <property type="protein sequence ID" value="TBU12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUM0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0794p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020978496" evidence="1">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="419" mass="48943" checksum="157DE2ECDFB9E72C" modified="2019-07-31" version="1" fragment="single">MFLYIFVYIVIASCIKVLFRAKNKNETDPSVFRFVNSLYGIFDENNSFVDISSDYTLDSNVMILDSLIPKVNHYVLLEYMYFDMTKIESNLMTFLLYYKDNFKDYIYLGDIISMDNFIFLLYLLNLSFVYSFEYDSNTFFEILNAIEYLDLFGNSRKIIINNLIEYFLLADKSMEILFTENYISPQFIPNIYNIYNEILLEGINLFNGKCIFRNSSLFILHENENIDNKSLLQTEGVHIFPCMLKLNVLNKFRMYFFSLIGFYMKMSNYAVLNLSEIDFLTENDTKIISCFSNVTEITLSSCFIKNSFIKIIPHSILCQSLDILKFSNILFDSKTFSEILNFRLKKISLDTCEITDGNFFTDLNLKESSKSLNSLILTGILLEQHDVEQISGLENLSELSIKNSSICSTLFEYLCKNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV46</accession>
    <name>A0A4Q9LV46_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0713p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000713">
        <property type="protein sequence ID" value="TBU12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV46"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0713p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="331" mass="39856" checksum="B846B7DA24F7B7C2" modified="2019-07-31" version="1" fragment="single">VRLYRYSYDETSNFTTNFVHFEWSKYKYIELNYDSSSTPLKFDNSVFKSLSYMNTIKYFLLQNIVITDELLLFVLRSTTIVYFGIRTFIYTNDYRFISDGNIINQKLAAFDLINSYSPIHTSLLVYLKRFRNVEVLKLKNICINHTELCFREIFKDFSCKNLSENKIYLKSLKIITDLVDEKTTNYLDWLFNVYAFSDILSIYYYVYRMSRTEYLLLNKMARIELLSIRINHKSDFIDFKMLFTDCNFFNTINFFSFHCKAIRKEDINILKKIKILKCLSLSCETIDYEIISCFKRKDFKTTKFEIYKPIRSERSAEINEYLDTEFKSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV71</accession>
    <name>A0A4Q9LV71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0533p0030</name>
        <name evidence="2" type="ORF">CWI38_0705p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000705">
        <property type="protein sequence ID" value="TBU12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000533">
        <property type="protein sequence ID" value="TBU13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0533p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0705p0010"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="16237" checksum="350FB5DE523CE68A" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISNNTKIKAANDADEVKKSDSEIQKCKLHPPAIPLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVQ2</accession>
    <name>A0A4Q9LVQ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0669p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000669">
        <property type="protein sequence ID" value="TBU12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVQ2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVQ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0669p0010"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="168" mass="19437" checksum="BCEEC95DC3C19706" modified="2019-07-31" version="1">MTERCIELCEISKDHLILDLGCGSGISGCVLSQYEYIWIGTDISHSMLKICKNKEFAFDLCRSDIGTNFCFKKNTFDKIISVSVLQWLFHSYSSTHEPFLRINIFFKNLFFVLKNHGQAVLQFYPENSKQTDIFIKVARKVGFHGGLVIDNEGTKNKKYFLVLRVFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR1</accession>
    <name>A0A4Q9LVR1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0626p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000626">
        <property type="protein sequence ID" value="TBU12798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0626p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="63377" checksum="32379824752D2FE7" modified="2019-07-31" version="1">MKSNKSYLFAGAGIGVYKYLGIIEDSRGIPTSKSFEEVQTKLIARVERLCRTRLNARNLFKTINQHAISLLNYHIGLDDAVRAVLVKNKIHLRPGCKERLYLPRKELGRGLHSVEFKSEHMLLQLLDCLEKHKDTSTRRAAILKVENNNKTPLSLIKNFLKIKYGLEEEVTKKKLEEAQLANLYNKSKTENYIQRSVRPRDEAVFCYIQDINVFWGAEGMCQHCNQSRKTVDHLATRCEKMLGHDYTRRHNEVFKSSKRIRSHSVQEILDNKYAEIRVDTRIKTDVKIRCNRPDIFVLDKRQNRITLIEVGITSQDSLQIVETEKLRKYDLLANGLGLIYKCSVKIIPYVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSKVLKKTVKTISFDRRRGLESGSNAEESWERASLSVILGAEMHKQPILPLKQVDNEEDDVKTENTKNILPLILDGITTAKEPSTNTNEELELEEEIEVVEMQNDVQIDGKNDFLLNFLIVNSINMILLNHNAPLEFIEKRALEIKKILENEEKYKEKKTEIYKFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW76</accession>
    <name>A0A4Q9LW76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0964p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000964">
        <property type="protein sequence ID" value="TBU11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0964p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="20051" checksum="776B1E1FF588C0B0" modified="2019-07-31" version="1">MIPIFLYFIFIVKAENLVFLKNIRRQGDIQIAELAFREPINVIKFGLYTNKDTKNQNGWVLQKDLTNYFLKNYYSGLETMEIVLQKSLPNKISYAFLLKDRKRGDNFTKPFFRNKTGIFSLEDTENYEENEKPDKTNSDEDDFKKNIIIGIIIIGVFLFIVIVLLICKCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW80</accession>
    <name>A0A4Q9LW80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0719p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000719">
        <property type="protein sequence ID" value="TBU12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0719p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="25951" checksum="33C00EE95D47C7E9" modified="2019-07-31" version="1">MAKITKKAWIGIGIAGAILVVIGTFIGIGYAKAGTVLKNFEDDYKKVSESDSFKTILKDLNDVKLADFVSVNGAKFFQSNFVSSADEAKNVDEALRDKKPDVLKNFTAAPAAAFNRVEIDTSKFASLVGDIGFLAKLGFVFRSSGPLKSIRSVSECINKIIKDDPKEKESMILAFISLADDKETKITEAKVADDGKVSSIADGKTFKRQDKGDVNRKPVDFVAFIAEKVKKQQATPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWH8</accession>
    <name>A0A4Q9LWH8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0535p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000535">
        <property type="protein sequence ID" value="TBU13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWH8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0535p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="57" mass="6563" checksum="6B993E877B894409" modified="2019-07-31" version="1">MPLVLLPEPRVRGINNSFKTNLIGERWKPLGETNIHIKEDSSQKKKKNSGKEAEEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX44</accession>
    <name>A0A4Q9LX44_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0461p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000461">
        <property type="protein sequence ID" value="TBU13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0461p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15771" checksum="C0889664A26C7C14" modified="2019-07-31" version="1" fragment="single">NILCSSYCKKRNLRKNRLKNICCMLSKPNSNDIEDFKLAADDLNLSEKHKNSKKRPQYILARQRIGVPSKKDRNYHNFETDQSKEMDVIPDFSSRPRNICTKSNGKLSSLKKIFFSNSKSRCPKSHFKRTVFIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX60</accession>
    <name>A0A4Q9LX60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0803p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000803">
        <property type="protein sequence ID" value="TBU12325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0803p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="786" mass="92806" checksum="218065AE3E29472B" modified="2019-07-31" version="1">MDLLIYIILGFIVIKSFVIFYTKKGKNGITKSVIILLSFGFCSSSCSGRVTLLLNASFCKENSDINKIHNSAIYSCKIHNRLEICYEDHTFKNNRIQCMKFGINVTHFILKKYIVEYPKDIPLISKFIERAIKSASNKNVEIILEKYYYDDFLCLMRILNAPDNLITPIVGLDLNFVFNFLLDFEIVYSKNLKYFLKSLGLNFFLHCKFSNRLNQIDFSKCLSSGINTSLVVVFVEQYLRFTFTRFQKLNDLCPRHPYSLHLNRDFTHNLFSKKSRIIVLDSNKSFFDEFLRKKILYATLKLLLNAMKLKKLVISHISQNFNCDPNKFANLIPFSCVKIIIKMFRNEQTFLSYIYPILKRPMIKKLKLSMNEISFETIEFLKQLKNINKISIPYYLPNNINIIEKILELPNYMPATQISLTLTNEIIETLSLLPKEYLNSMTNKNLALHIDFPKNIDILFSKIYKTLNLENFIETLKIGCNENLNKNQAKILSMFKKIKDFSLFFRIIGDSPYYKLQEFDFVSNFNFMKKILIFNSTISLELFYFVFHSKTLKRVYFTQIDISEAMNSNFNFPNFNFCVEKFYLKLINRPFNRNLLEYLQCFKQLKFIEISSIAPQLRIHFDIHFHTTNDKLLEFFNDDKVDSNGFLYIKKLNMCQITFDSELLNGIFDKHWSLKNICELKLASTILYNKDMSFLSSLKLLTSIHFEKVKFVNCFFSDILSKYMLKNITVLYLDNIEFVKNDFIKISQLKNLELFSAYFGDHFSINRIKFVSLNDFLFHLETRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXL7</accession>
    <name>A0A4Q9LXL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subunit theta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1090p0010</name>
        <name evidence="8" type="ORF">CWI38_0427p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001090">
        <property type="protein sequence ID" value="TBU00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000427">
        <property type="protein sequence ID" value="TBU13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXL7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LXL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1090p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0427p0020"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="494" mass="55659" checksum="A0408320EB57F953" modified="2019-07-31" version="1">MSYNTNLSSLISNKSTHSISPTQASINNLAAILSFLDTKKNESNNISPLKLVITPYSTIAVSNPSLILPNLPINHPIAKLFSIYLEKAQTLNIPQNLFIHLTHSTLTLTNSLLNKNIKPGDINKVYSQFISHIRQCAKNSQKNTQIILSSSESNILDKLLIPFINSSKLRNLVIQAILTTKSMDIDRIRTVKAIRGNIEDSYLIKGMVIERRPCTKNKILIPRNNKFDPSITEEYSVSIYDCPFDISRTETKGTLLFTDSKELLSYSSNSLENIENLVNEIQSDVVICNGKIEDIHLQMINMKNMVGIKILSKHDIRRLQIMCGGSVNKVMGSGCVGSLRGVGIFRENEEYSVIYGNGKVVSIVMCESVESRIADWEREIEDGLNMLKRYFIKEEKESEKGSFNTLSLPCYFKDLSSFLLNVSKSYEDISRLIYKQLGVMYGDMVITGEYACEGVIRCFEYCMEIMGVILQTSEYVLVKGEGVTVRENKGWDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXN9</accession>
    <name>A0A4Q9LXN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0532p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000532">
        <property type="protein sequence ID" value="TBU13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0532p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6087" checksum="110DEED43CB5803B" modified="2019-07-31" version="1">MLLVLGIGWRGVINMYMLVKGVINTRDMLVKGVINTMDILEGGVINTMDILEGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXY6</accession>
    <name>A0A4Q9LXY6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0706p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000706">
        <property type="protein sequence ID" value="TBU12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXY6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0706p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00600">
        <property type="entry name" value="Sm_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020327849" description="Sm domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="16909" checksum="64BE5CDFE086C3B5" modified="2019-07-31" version="1">MFYLSLNIFFSFLFSYFFVNISCSDRNGSQIENIGMKKMEKSNSGSDKNKDSGCGFHGCGITCNHVSVIISRSDSDSKVKFSSNAKYEGVLKSTDKNYNYVVSDTEECINDQRGRYLGLVLFRGHCVLNVSIICKEKDIQKKEVDRFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY43</accession>
    <name>A0A4Q9LY43_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0473p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000473">
        <property type="protein sequence ID" value="TBU13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY43"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0473p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="156" mass="18500" checksum="48A2AEA8114B431D" modified="2019-07-31" version="1">MKFLYAQACAFKLKESDFITTDVKNRILRIGNAYYITNYDKLLPQIRDNRLILEVLFNLFTIQVIHLQNIDRIRSEVENILSLVLNKLEKIVFFNLKYCVYLSEEVKNISRISFFGILDEYRMNEKLIHGKDEPFTPEIICLITDLNISFSRKLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY69</accession>
    <name>A0A4Q9LY69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0337p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000337">
        <property type="protein sequence ID" value="TBU13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY69"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0337p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020755547" evidence="3">
        <location>
            <begin position="21"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="615" mass="72368" checksum="337FE5F43EC4AFE0" modified="2019-07-31" version="1">MFFTIFLCFEILHCYTGLNGDPTIVENCCIELDLVPQTNREISIIIKTIDSDMLPWKLNELASVISYYIEYVKKYTNSVHHKFLTRFICLIVYIIHQKNKTEPIVYKTELLFNILSFAKLYEYNRCNKEMNDIEKARIVSLFKTGMKRIEYIHESLEIRTHKIEIDYLLTIKNIETSCDLNSDLDFKILDNTYVVDERNIESDLSNYLKSGSFEQTYSFYLYLKLDFLLKNREELNYEVIIFPLNQIFFNKDFFNQLLDLNLSLTKDLSIKFDQVKYKKFMMFISEPYINTVLNQSSSFDSIFEFSEKTFFSKNENISKEFPEYLLEFFIEKQYENQIDLIYGFLDDISTPQFNKYILLVLCLKFPCFNQNICNKEILLRIILECIFLTNILSPEIINVKGLISGEILEINLFQILEQHLQNQNIKIKIPIDRKALFQRYIPETFKFLENMAPSNLKPVFVPILQPESESQPEQETATRREPAHEREPKTKREPETIREPASKHAFERAPKAPYANKPLTNVHKKENSPNPPPNTKVVQKNNGTNPENLTETTRSSKLKKQESKILESETESKRSEAKPQEENNAFRTILIVVLVFTSVIGISATGYWIYLEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYE5</accession>
    <name>A0A4Q9LYE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0440p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000440">
        <property type="protein sequence ID" value="TBU13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0440p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="635" mass="75425" checksum="B64028683A6C85A6" modified="2019-07-31" version="1">MFVCFMYFMKCFSAAYEEVTSECIENVYEELTRERLEKEHAEVSKVYDENDYEKISELGLYTNPRDCIENLRFQIQTEKIITKNIVFSYDTSPFDLYESYSDISFKTIFQNIINFYEKNDLKTVLKRENETFNAKSKLFCILKSLKISIFLLRKIPFVTDQYLIYNSKIFAFWYGLFYMNTKEQNNDGDFLHFSFQKQFYLENFIIIDCFLHKSDLFDIFNEFLSTNYKISLNKNLNYIEMIIEKALIENSDSTFLIAEELCKMASHNFSILFLSILTYFHWGSSTYRNSRIFLDQIARNEIIDIYKKLEIYLEDRINLINLVCLNIGWDVTCYLFNVYGLGVDTWFESYKLASQKCVIHFKLPFTKISFHVSDNIKNHLVILNSSITGLSRIHSELTKVKIRFLVYILMSLNLDPEDDELCIILKLYLTYGMVLYNLDSINLTDNLNLKNNNFINWLSYINSALNGFYYLRISVYTKFLCAKKLFTLILVMIISLEIDYKTKLNFQGLIEKLLISLKMHGFDICANLLKEDSEKLQNNRIFNDKFFPFYYNALVVCKNAGFEDFEVFLSNIADMKNLLFVNLSSELENEDVINLPKPHDREICWEKYSSHLRIVSKDFRNLENKYRNLTLIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYL8</accession>
    <name>A0A4Q9LYL8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0293p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000293">
        <property type="protein sequence ID" value="TBU16704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYL8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0293p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU16704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="580" mass="68397" checksum="F4301C04C408A38A" modified="2019-07-31" version="1">MSYFTRIIVLKLLINYGNFAFLATFSENISSISFFTTNKKNCEKNEAFCFEEYENQILNYLNDKNKLLLNNYIPENMPIILKQECIYDVKNGFIDLLEAVFAKTDICLFAENMKEKTKILGFILGIRDKYFRCMIEQKFSLLLENLSQIKFETKNDSQSEKNHKEINSLGVASKNKKKFKRSDMKVQVEECIECDPLLTESIDIFARILTDLEFILLIFCFDGFFEQVFQYLNIDFGKVNRTCLCESESNWVTGFFNKKSIFNILKGAEKKIHGASNGSNCIDLLNEECEIRYFTFCSQLNMFFDCLVYDNLKVFEKHFFDLFICKTISIPEFSKHEIIIYINFFYQEKVLKIGLTNISLKNGDLYLQIKLDNFSSNKQILNRFSEKILSIPNDYLKFNLIFIDISFFRNSCLISVKENFDVSWSQHNNDLSSVFNIKSLTFNQYLNFLRSLKLEIYRLQSKYLRFKIIIVEENILNQAKLAEILHMVLNKYIKSTVKYSKTSFTDDLTISRIKKLLYNTQTDYNIYNEYLNLIDSLKEALSKLFSEFFYNKSIEVVFCDRNNDDSFDTEKIMSLIKNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYU9</accession>
    <name>A0A4Q9LYU9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0392p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000392">
        <property type="protein sequence ID" value="TBU13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYU9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0392p0040"/>
    <dbReference type="OrthoDB" id="2200806at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="167" mass="18571" checksum="DD36F05C5AF9AF09" modified="2019-07-31" version="1" fragment="single">MGRKKNVSSEISKNTKIKAANDADELKKSDSEVQKCKLHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTSPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRHYNEKFSCTETLEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ35</accession>
    <name>A0A4Q9LZ35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0091p0040</name>
        <name evidence="3" type="ORF">CWI38_0261p0040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000261">
        <property type="protein sequence ID" value="TBU17973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000091">
        <property type="protein sequence ID" value="TBU20310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0091p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0261p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU17973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="375" mass="44773" checksum="6E9455CA73E0AB12" modified="2019-07-31" version="1">MLSDKDIEDLEEKFSDSFIFSKESKFKNSHINNNYDNDSFLFSKESKFKDSHINNNYDNDSLQHFYDFSKIKTKGILQEKNIFKDKTAKKTNTHNTNTYNASNHNVSNHNINSYKTDKYTHNETPRKTNNNVNNYKKYQENLNEEPISYKNINLHKNNNSEEKDSQLYTNTFTISKSIKEDINEGFNNKDYQSNNKNIVDQPLNYKLNKENTNENHNSKSVKSKEQFRKYSNKENTNENHNSKSVKNNITDYKNTENLTKLQHELDNLKDTHKRMLQIKSKLLYLIDIEVQKVKKSIIFKKNEEIKSIINKYQSIILEKDSIINNLKLQANDKIDINNRDDKDELEIYKRKVEKYKDAYIKLKEKYRRDILNKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ76</accession>
    <name>A0A4Q9LZ76_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0528p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000528">
        <property type="protein sequence ID" value="TBU13110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ76"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0528p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="114" mass="13349" checksum="E3BAE18983D52927" modified="2019-07-31" version="1">MSLFEVGDTEITLKDMLLWSGILTFLCILMYSYMEIRKYLKKRTIRRLNDESFLQKILKKIDCCVPVDVERFIGSIKYKMTVESISSDLGKELETRPNTEKSWESALLNVDKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ89</accession>
    <name>A0A4Q9LZ89_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0351p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000351">
        <property type="protein sequence ID" value="TBU13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ89"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0351p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="49664" checksum="D1B5A1CD287AF9E7" modified="2019-07-31" version="1">MLLFIEKLRTDFPIFNLLVLFFLKGNLYTVDDLNEKLTESLKEIYEWKEKTMRRFFNSDFYDIKLEKPTLSPEMNQLVCNYINSSASRNFNIFLEYICCKQRARSIPDNIYFFTLNKLENNDFMFGIKYKNKENKTGTVKEKHIFLKNKTIRILLSFLFNLSLVFRKYYPDSIRTTGLSYKYSLANYRFMIFDSEFCFKNIVDLPNKGLMAHYSDSVGRCKPVVSTKIKLSGKLPGFQPINDLDLILKKSFNLFSTLKANYKIKAAWRFGNGFVEGEYERQCNLKTFVTEKIQELFNEKNILNTEALSIQEYSSKCKFSTDGLIGSPGYRREIKIHLSWQRLPYSVQFFLKESNEDTRKYGLICSFTSNDAVEFEILSDKDLIITKIVKITKERFVFRDLLASYEYEETIGKYMKEIMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZE6</accession>
    <name>A0A4Q9LZE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0333p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000333">
        <property type="protein sequence ID" value="TBU13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0333p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020585931" evidence="1">
        <location>
            <begin position="18"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="481" mass="57297" checksum="D7FA895D18DD4247" modified="2019-07-31" version="1">MNLLFLSLILLFCLSKASNLANPLDIDTSGTRNAMNNCKESNKSKDIETEECLNVILSNIPFFTISFVLFCAPKFGNFYNLFSEFFLRKYNALLNDFYCFTAFTEYDLYYSTTKSILRYFRRWIINEAIDSKVFDGNENNILNEILMKDDIFEKYLEEVVQEKREILKWLENMQIFYYKEDYLEILRNSLHCIEFSRFIRTESLLIFKEIFILLFVINNSSISILSQECPPECNDFKVKENYFINILRRSYNRNKWKSLKIFQKREICERIDSNTLILITGLDVMCKIFSDKMDPNNLNKNTFSRICYLKGTVYPTLFRSNEIKMYLPHEYDQNFIEYLQKFLSKSESKIIFVTLFFSYTDFIVACFLKEILSKFGEKEFYDFFTSDAVKTNEYMKNKAFNDTIHEISTKTSIYEEITTYFIHLSQSMKTQLFLKVSIIKNEEINFLKIFDDILPSIMSWNLRNNIRNDVFNSKMTTGSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZJ5</accession>
    <name>A0A4Q9LZJ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spindle pole body-associated protein Sad1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0210p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000210">
        <property type="protein sequence ID" value="TBU19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZJ5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZJ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0210p0010"/>
    <dbReference type="OrthoDB" id="2190654at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="129"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="298" mass="34954" checksum="869437E822530947" modified="2019-07-31" version="1">MDKRKTLKVIRTPDNSFNLNPDDTLFLETPNIKSKQKKNVKYYDTTDINIQDTFEQDEPNTFLNKCTRIFEKLIATSIFLWNINFVKFLLIFSCAFFFENFLHKKNNFDSDLLTEIKKDFLNLQEETTNLSLKLTQILQTPTKPKQPKITQNYALPETGASICYTETSPIYKHWLFRFITGKDPLILLTSNLLPTQCFSFNGTTGKIRINFKKPIKISHFSIFHPNTKNKTSAPKDFEIQTQNTTLHTYKYDITNTQLQTFILHTQPTTNNIIFHIKNNHGNTKYTSIYRIYIFGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS9</accession>
    <name>A0A4Q9LZS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0324p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000324">
        <property type="protein sequence ID" value="TBU14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0324p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="359" mass="42590" checksum="EB9BCFAB3356B94C" modified="2019-07-31" version="1" fragment="single">MTNSNWIILYWVKFLLFICLGFWQFVICTSESNDGKITFALIDLNWKEDIDKVEIKKIKYWLSRSNEEETFTFCPGNHVIKCRGLSITDFACSLERSSQNHQPLHSFEVNYKENWKIKFRSLNRFVYMQLEEYPFLFEYSLNVSYQEFQIFVKHLTFDSGTPRQNLTYENFYRFLKILDVLDPISSEYLNQFYSHLYRECLLEKVSVRIFEDSAHYRENLFDEKHRIRPFMYFFCTLINSIDACFIPKSSTLSLFEKKKQHIDECFRDSIDIANLILKISSSSLELLLRSLKTNEWAAFNWLLAVTKVSGFYIDNTELTFNELKVSSVCSLVCSESFEKCIVSLKKISDDFFLNLTGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M017</accession>
    <name>A0A4Q9M017_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_0207p0010</name>
        <name evidence="11" type="ORF">CWI38_0178p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000207">
        <property type="protein sequence ID" value="TBU03939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000178">
        <property type="protein sequence ID" value="TBU19895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M017"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M017"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0207p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0178p0010"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU03939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="281" mass="32024" checksum="81ABDD56AEF1DCC8" modified="2019-07-31" version="1">MEKESKKLVGAHLSVVKGIYTVQEQMDLLGSETCAFFVKNQRRYFSSGMKIEDIEKFKKNIKNSEVLLPHGSYLINLGNPDPDILEKSVACLRDDLKRCNDLSIKYYNMHPGSDVKKRGIKCLKQIANKINEVIKDIPNVIILLENMAGQGTVVGSKFEELKEIISNIEDKSRIGVCLDTCHLFGAGYDIRTEEKFRKVMNQFDKIIGLEYLKAMHLNDSKEPLGSKKDRHECIGKGHIGLEAFKFIMNNDIFDNKPLILETPEPEKYGEEIKLLKSLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M036</accession>
    <name>A0A4Q9M036_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0163p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000163">
        <property type="protein sequence ID" value="TBU19960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M036"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0163p0040"/>
    <dbReference type="OrthoDB" id="2194794at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="67"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="188" mass="21882" checksum="08F09B41F3B86F8F" modified="2019-07-31" version="1">MAEWVKCTFNIDVSTSTIDRALREFHYTLKRVTLVTERRNTLSTIELRTNYATSFREFEVDNDDKNFVCLDKVGFAVVTRCCRGRNMRGESAYLSVTAARSRNISVVAAINKYGMIYHKNHERVVNGEDFKLSIKVINESWQRQGILSPIFVMDNSRIHHYRGLNDDEEIASYRIKYLPPYSPFLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0G3</accession>
    <name>A0A4Q9M0G3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0128p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000128">
        <property type="protein sequence ID" value="TBU20124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0G3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0128p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="81" mass="9677" checksum="9F70F4A63CA073F8" modified="2019-07-31" version="1">MLNILNHVYIKNTNPSVFMNNNQPFVNIFDTIEEVKDETFSKRTNINNISEEIPLEEISYKIDGWFDDSIHDNMKFNYEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I9</accession>
    <name>A0A4Q9M0I9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0123p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000123">
        <property type="protein sequence ID" value="TBU20150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0123p0010"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="138" mass="15580" checksum="E3208FECA1612707" modified="2019-07-31" version="1" fragment="single">MQNSGLDTLPSPNAPVPSSVEVSACEPSYDMTNPCTLAIPEGNRLMALRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0J9</accession>
    <name>A0A4Q9M0J9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0122p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000122">
        <property type="protein sequence ID" value="TBU20160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0J9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0122p0030"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="149" mass="17594" checksum="842BF7C9BA9C22CF" modified="2019-07-31" version="1">MIENKEGKYKRNEVDFPHPVPLCLRFKLSLYLPGTKDRKYIYSVEPKKETNITQLFNCFENSKGALEIKIKSPKIENTRKIKASAGFKTCRSFVEIEKRKLHSKLYNAKKMRLYVFSTSRNAQRKGIIKQNDELSFCYIKDINVFCRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U6</accession>
    <name>A0A4Q9M0U6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0227p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000227">
        <property type="protein sequence ID" value="TBU18865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0227p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9707" checksum="B0FDC61F0DC833C9" modified="2019-07-31" version="1">MSTKNAKLIQEVLDLNPGFDTMIDSQYEVMDDSLSATFKATRFEQFRRAIDCFLLRFKISNDTLVLEHDGPSDTVSSKNDKKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M105</accession>
    <name>A0A4Q9M105_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit ASH2 of Set1/Ash2 histone methyltransferase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_1561p0010</name>
        <name evidence="6" type="ORF">CWI38_0343p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001561">
        <property type="protein sequence ID" value="TBT98864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000343">
        <property type="protein sequence ID" value="TBU13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M105"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M105"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1561p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0343p0010"/>
    <dbReference type="OrthoDB" id="2186329at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBT98864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="200" mass="22382" checksum="579015246CE1D7DE" modified="2019-07-31" version="1">MNLLDQRRTPKICISSELSHGGLEIYNNNLSLKGYGGYRSALSTHGLLSGNFYYEAQIESKSGNIRLGFGQKNTDIYAPAGYDKYSYSYGDANGYIFHNSVRKTYSDTFKYKDIIGVLLSINTEPTVLKDYTRSTLVLDSSLKFVSRFSFIKFFKNGEDLGIAFSNINPGIYHAVVSLYCGGEVSLNFGPFFAYPIDNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M140</accession>
    <name>A0A4Q9M140_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0342p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000342">
        <property type="protein sequence ID" value="TBU13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0342p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020617494" evidence="2">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="21517" checksum="53801174C567A4D9" modified="2019-07-31" version="1">MNVIAHHKIVWIFSVILFASPGSDVVTFAPVGGIGGLGFGLFVGGLFVGGVFVGGVFVGGVFVGGVFGGGVFAGGVFVGGVFVGGVFVGGMFAGGVFVGGVFVGGVFVGGMFVGGMFVGGVFAGGVFVGGVFVGGMFVGGVFVGGEGDFGISPVFGKFDPVLGCSFCSTGFVSCAFSVFSSFESDLFLNSKYPSEAKEIETATIATIKIIFFFSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M192</accession>
    <name>A0A4Q9M192_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0076p0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000076">
        <property type="protein sequence ID" value="TBU20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M192"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0076p0080"/>
    <dbReference type="OrthoDB" id="2194511at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="35390" checksum="92D63E47D7BE3030" modified="2019-07-31" version="1">MYSKEEKRLLRQKVEYFTLFRDEICFKRRDHLIRAFFGFETALIQQITQIEHSVAHISVNKRIALIIKKYYGILKAYIKEYVKDCEACSRLNSLKTIQPIYINHIIKKYDLFMMDCVDFRRYSDQNDQSFLTDLNIKIILVRPRNLKAQGQVERVNQTLKRWLATKLHETGGKGWIEHLVITIHKATNKSPFMLFFEQPGLNNLLSRSIIVENEAGKIVPAIDIDPDIVSAEENAADTQWILEIASDLHEEVAETVTTITTIIADDHESDGNIRSDFAKHFKNYREENIRSNNLNRLNMDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1H2</accession>
    <name>A0A4Q9M1H2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0299p0020</name>
        <name evidence="7" type="ORF">CWI38_0348p0050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000348">
        <property type="protein sequence ID" value="TBU13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000299">
        <property type="protein sequence ID" value="TBU16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1H2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1H2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0299p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0348p0050"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="194"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="198"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="325" mass="38533" checksum="804360408DFCC607" modified="2019-07-31" version="1">MLGRTHEKESIKKIMPLRNITNRKKEAKKYKDTSNLNFSETEDAIYRLRELDDSRDVTMYYEYAEMVFIFFKKLETEYLLKNNFMNIQKEIGWSERCLLVDWIIEVHWKLGLVPETLYHTVYIMDKLLSLRVVSTEKLQLLGITCLLISSKYEEVVCPSIETFVILSEKTISEEEIRKAERYVLSVLDFQLNYPSPLNFLRKCSKANNYEYKTRMVAKYLMELTFFYPQFRSISGSLVSASSMFLSRKILEMNENENIFFFYSGYSKKDVQSCANEIFSIILQPIMYENVQKKYSSSKMLKVSNFIKDFSKEYLKNSNINSIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1Y8</accession>
    <name>A0A4Q9M1Y8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0220p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1Y8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="105" mass="12795" checksum="ADE712C6A476071B" modified="2019-07-31" version="1">MKLRLYYNLYFFIGILLYILAENIQNYRFTVNISANPIIYTDEYKVDLYNRVSEKLCTNKFCDILQELRNNTKTLEQCREEICNWEDLLDDEREYIDMLFVCGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M211</accession>
    <name>A0A4Q9M211_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0023p0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M211"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0140"/>
    <dbReference type="OrthoDB" id="10309659at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32735" checksum="2213147FB5B08573" modified="2019-07-31" version="1">MAKLVLNDVSGNTFFEKEYTHEETVLDVKKYVIKKIKEKESNEMHGAFCKYDINETLIAENMNERKEKETEVIEENNKYNVEDISTQWIQIIFNGKIVSETVPLVSLGENGDLFLKFDVKKNCTSIFSESCFNVKKRIIRPNEMEEEGSVEMNQIDRKVFVKILDNGRKIKVDPSKLVTNKGILYYVTEKKKKTDFLATIRSAILGIRTDLLVKILVIVGLMFTRNREFAFLLMIILLLRAMSTLPLKIKTKYNGSFELLYKSVLSFVFSMIFITFDDILQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M295</accession>
    <name>A0A4Q9M295_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0014p0090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M295"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0090"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="412" mass="49113" checksum="1D8054AA573B183B" modified="2019-07-31" version="1">MINIRNIFYHLHHWYVKFTYISLFIYLNTAQIQLNNLNSENFEYGNDSSENFKIEITENSDEEISEDQINIFFELIFNQRECILFRYTNLSSGFNTVFYGSEPDIIFIPKETEEEQSTLDSRIRNQNNYSWDCIRTVKEFIQIISTNLSDINRLWEVLDIYDSSLNEHLQAILMGMTCFDLQTIDKILAKFINIHYMSSNLYNYLKELQFLLESTSSNVLNALNSFTYPESEIKNSFHCLCEKISEVQKNCDLVDRKKILFISTFHYANRDEMIYDSEIQFWKYKFIQERDRYNAYINNTTTTNTLSNPEENIFIYKNSSVDFENSLNSILNELKICSAAYLQLLNIIKTIHDNKNYPENLSTEVSNSYENQIKRLNHILESTINDLQYYLISFVFSRFEQINLFHVSFFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2A5</accession>
    <name>A0A4Q9M2A5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2419p0010</name>
        <name evidence="2" type="ORF">CWI38_0013p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002419">
        <property type="protein sequence ID" value="TBT97222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000013">
        <property type="protein sequence ID" value="TBU20884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2A5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2419p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0013p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8799" checksum="2B7AB5FF1A0F91EF" modified="2019-07-31" version="1">MTNPSYITIICKNQTIKQRITLLSNSSIEDLKNILCKKIHSHTSAIILQRGKEQLRNDLQLDILGIVDGACLEIYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D2</accession>
    <name>A0A4Q9M2D2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH/CRA C-terminal to LisH motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0010p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000010">
        <property type="protein sequence ID" value="TBU20910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2D2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0010p0050"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH/CRA C-terminal to LisH motif" evidence="2">
        <location>
            <begin position="109"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="358" mass="42804" checksum="F571013BAF08F70B" modified="2019-07-31" version="1">MDLSIIQKSKRQNLIRSTYKLIEKLFYIHTIKKISTEALNEKLEKLKTLLKSINTQIEDLNSVIIQRQDTDKELYVLINEHLLYHGYFETSKKFVKEFEIEKYNDYSFFKEMYETKQEIYNGKFDKVLHFCKEYKTTLKNMTIPIKNEYLTTFIKLNIHQNKENHTEFNCSDIENMFRVQEYIELCKNCKYKEAMLYAKETFCKNTFLIKPFLPLLVCRDVSTLKDQISNNYDLLVYIYSKSLYKIHKLSFESRLTRLVECGLIATKTRFCEKNKNMKCPGCMPFLMDLAAKLPFYKREQSILLCKGLDVEMNDRNQPYMFDSGYVYSDLYISETGHLFICKVTGEICEKKPRRCYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D7</accession>
    <name>A0A4Q9M2D7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="10" type="ORF">CWI38_0087p0040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2D7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0040"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="225" mass="26414" checksum="BAED5ABB566C5210" modified="2019-07-31" version="1">MANLPRKKDFRQRAHANPFSDKHFDYPKSPCEMNWSEFYIDGIAPKIVDIGCGYGNFLILLSKIFPTENVVGLEIRKKVVDYIKNKVSVMIERKELKRNLHAIYTNAMLFLPNYFGKEQVSKIFILFPDPHFKKKKRKARIICTQMLDQYAYILENKGRLYLSTDVSELFESMVQCVQNHTLFRRLENEEFENDNLRTLIIKETDESKRAAVKTGKAFAAIFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2H3</accession>
    <name>A0A4Q9M2H3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0114p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000114">
        <property type="protein sequence ID" value="TBU20198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2H3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0114p0020"/>
    <dbReference type="OrthoDB" id="2191163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="283" mass="33392" checksum="3639EC6904C19838" modified="2019-07-31" version="1">MLRNGWPDTLRYHSEKSHCPLDIGSVVRTRKLQSKLALSQNSRKTLRKIIREFNLDLSRINDLSESLVKKNEFLDVYAKKQHFMKLVRNFEERPVCLSCSDIMSIVTKFQNNSLTMWNENIKRIHVYKYIGIIEDSRGILTNKSLKELDDAVQLQIGLDCDVKKRSARPRDEAVYFQHCNQSRKIVDALVTRCEKIPGYTMFYNIMKACRGKKDTRIKTDVRIRCNRPDLLVLDKRRNKRTNAMNDRAYIQYTVLRRNSKYFLSEPNAKESRECVSLSNIREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2V9</accession>
    <name>A0A4Q9M2V9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0185p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000185">
        <property type="protein sequence ID" value="TBU19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2V9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0185p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="781" mass="91255" checksum="DA6B01DCE9C5CB48" modified="2019-07-31" version="1">MQTYSKNNVVNSFIKNFLFQNKILMKVLLISFIFSKCIDIRLFYVDKTVEIGQSRTNSNTFDSIVASTTIFVKDENKCYEIPEFKDYIKSNHLAKTINNFAVQYKAESKLTVGLFERNPGIKNFFVGKIPKKQLEVLLLLLNRSSFFLYENLSQNTFLEFLSLSKFFEIKNEKKFENFPKELILYYNKKLKDEYFKNLTIDFRTLQQEIDNWVILKSFDILLHYLDINFILYRNNLSETFEGEILDKNTFFLNDGDNVDITISPTLVHTWQTFYRSFSKQPFLNFLLKLINVNIVEVTGFQEANIFEFGLLMDLIPQKADILYVHDTLTYRILGLLCVFSFTETIRILKIKDKTLDTASMYKLFGFKKLRNLIIEVEILSNSVLDLIFEVVKGMNLESLSITCEDFLNTSKNLTVEMPKKIPCYNFSIRKYFSIGDDAFKSMIVKSYGNVLTSISVEIANFSADEILNFFSVFPNLTGLCICNNETIKGNKDLLLPNFGKYKLKSLKLQKFVIGSELLNQILNASDIKFLSLVKCQIKVVPDLFQNPSSPNNSLETLDIFDSNFIPSFFYNNFVFRIKNLKRYNYSGTYMKFEMVRHNSQFDSEIFNSNTLLDISNNEISNLSNKDANNLEFNLIALYFRDCSFKRFILKDIELNLNEAFVFRSMRSIVNLTLNNVRYTEEAHSLSYILNHSTFSENLKSLCLINMDLHLNDVKSSNRLSSMENLTLNNIQKRQKVSCFTALKRLSFPKLKEINIIEDNDKDYLLYLKEEFPQEMLKFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M325</accession>
    <name>A0A4Q9M325_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED18</name>
        <name evidence="2" type="ORF">CWI38_0047p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M325"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21100" checksum="6D25DA2461BE648B" modified="2019-07-31" version="1">MILSYKNFIPQKIARIDTYLKSKDHKIILQSCSNSNFLIYKNEPDPTKTLKTIINKINRSEVLNCEDTISFLNLANFKQEKKLFVEGIEYVKDNIHIEVTVHSITNSDIIINEAFMENFIRNYMTNEIDNSLFNSCETFFVKIYTFAQTSEEGENLVFSESINLKKYINLQKPPVNFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H0</accession>
    <name>A0A4Q9M3H0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0027p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000027">
        <property type="protein sequence ID" value="TBU20747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0027p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="413" mass="49470" checksum="DA7B22763A12D800" modified="2019-07-31" version="1">MFSNNTLIPECLFKGYKKYKAYKESINKEIEICSNLIISGLKKIISNFYPSNSTNLNSNNERMILSKEELKAKFEDELKSIDINIFNAEYLLNICSDFNKIEELSFHSMSTQEIIKNILEINGIKDILNPFDSPDQAILVHEILVFCNLYNEKIETSIKKNHVISMCFLGKALFNYLNNIELKQLYLRVSQIKNDYEKKLHRLEAIKKLFYVGNLFENSLRCLKNQELKANFYGLLNICRFHNLICKLYRYDYLLFSLQIPLYISMVLEMNIVFDSETTIEFVSFILFVFKQENLDYPDFYNDKFEYFLEKSDLNSENIIKNNWDIVNKYLIQTIITWLKGACIFILKNFLENDKIENNKNRRLRILYISQLHYMNFYKSKNLCFPDQRNRMYEYVKRIYERVEEFYGDIINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3N1</accession>
    <name>A0A4Q9M3N1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0114p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000114">
        <property type="protein sequence ID" value="TBU20201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3N1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3N1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0114p0050"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="303" mass="35452" checksum="17E3299C2259FE40" modified="2019-07-31" version="1">MSVVKRLVTVEEEKQIETIKAIACEVNKEELSTFLQKISTTYKIPKYLKRVKNNIVLVSLETTLNISFLPNTLVVDVPSTQPITREQYDQCKKIWPCNFYPKKIEKLELPNTLILSVFQNIYEINNSKGINEINYSKDLNNILDLTDYKNISFIKNNLQIDNNISEKQFFYQFFYQFFTNVNKKKENILFCCGTACIIDTSNKKVIEISKDTSHILEHAIFKCIEKVSKNKETYLCTGYDAFCVFEPCISCGMALVHARIQRLFSIFPNKHSGIFSVHRLNQNPNINHRFEVYFLKEKYKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M459</accession>
    <name>A0A4Q9M459_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_1682p0020</name>
        <name evidence="8" type="ORF">CWI38_0057p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001682">
        <property type="protein sequence ID" value="TBT98597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000057">
        <property type="protein sequence ID" value="TBU20522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M459"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M459"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1682p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0057p0020"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT98597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="158" mass="17898" checksum="EA7D8C70F19954B8" modified="2019-07-31" version="1">MQIFVKTLTGKTITLEVEDSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLGDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDNSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLQDYNIQKESTLHLVLRLRGGMSHDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4P0</accession>
    <name>A0A4Q9M4P0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0055p0040</name>
        <name evidence="1" type="ORF">CWI38_0176p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000176">
        <property type="protein sequence ID" value="TBU19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000055">
        <property type="protein sequence ID" value="TBU20541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4P0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0055p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0176p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="421" mass="50409" checksum="93F0BE1C7BD1A7E6" modified="2019-07-31" version="1">MFFFCFFEAFCLCANNSNEKYNIDEYREYFMKKSLDLFNEETKQLENLCNIIESTDLIFYDAHLEFAVESLSTFFYSKISKKYKMDIFRRVLKTNFETETIEFKAFKLKQLEKNTYYIHSIKISACKNINNRSRRNFTILNENIFKAFLTNFFKMYKCLRKISKFYDTNDSSYVSIVDISSNKSKKIPVKFQPNNSYLLPYLYNVSCVNIVSEAENIDLNLEKTKMIGMFELRFGKHSYFLHGYYNLYMIDTNMSESYEDLYVSKISKKNMISLYSITFYNLMSLDYYETVILPAKRAYGYETLIKYIKFEYFHTKNSIDDVSKFMILFTDSQITFEFNFNWFAPYEIFKNYTPAIPIYIHTKLGESLHIYIIELKRCTDKDFFEILNVIDFPSSYGLLSTKNNEEPNENFTLKNIIDYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4X7</accession>
    <name>A0A4Q9M4X7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0011p0010</name>
        <name evidence="2" type="ORF">CWI38_0021p0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000011">
        <property type="protein sequence ID" value="TBU05449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000021">
        <property type="protein sequence ID" value="TBU20812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4X7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0011p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0021p0180"/>
    <dbReference type="OrthoDB" id="2191689at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="313" mass="37354" checksum="EE8502D7AD08C91A" modified="2019-07-31" version="1">MRKDEEYCLHKELVNGICVECGIILTENNFNYEFDYNTMAPKSNIKKQWKYSVKIDDYEEITQIEQILTPLEKLEYKNEVLEILKTKKFKSRIGKIDKIVCIIYFILKRDCFPISTTDLAKFSKKNKKFLLKNVFKEFPFIKISPEYLKNLFKRFINEIERKGFDLNKITDEYSTMLNDLIQIVESNTHKNIHELIMAFILYQIEENNEIELFSVILPVEIYKKFKNKFLDFYEKNNQKSTFLTKTNTFNKITQRVDKACAKLKGKDIFYDKKIDMIDIIIEKLLIQGYNPDVLKTYTTRKLKSLSIKSDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JTY7</accession>
    <name>A0A4V2JTY7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1906p0020</name>
        <name evidence="3" type="ORF">CWI38_1780p0040</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001906">
        <property type="protein sequence ID" value="TBT98101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001780">
        <property type="protein sequence ID" value="TBU10413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JTY7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JTY7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1906p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1780p0040"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="105" mass="12606" checksum="0D0440A9A1F8E017" modified="2019-07-31" version="1">MTPVIIQITVKDEEEAEKIKSELFTKQLVACIQEYKIKSSYPWKGNLESSEEILLSIKTFRKLILKIEKIISRLHSYETPQFICYKLDYVTRKYKRWMKEATRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JUQ7</accession>
    <name>A0A4V2JUQ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0862p0010</name>
        <name evidence="3" type="ORF">CWI38_1253p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000862">
        <property type="protein sequence ID" value="TBU00912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001253">
        <property type="protein sequence ID" value="TBU11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JUQ7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JUQ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0862p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1253p0020"/>
    <dbReference type="OrthoDB" id="2191719at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="345" mass="40405" checksum="DFF618630AA3C299" modified="2019-07-31" version="1">MQDNSFNCTFSQGKSRMRILMNMLRSKTGLLFEIILTRLRIFKSDEYIRKCNTKFKGTYELCSEDENSSDYSLSTQFCKFPEKRPESPDPIYKSDLKLQKIRRIEYYDNINVDNSNCNTNNINKFSSADVLYNSKSLVKFDVEKLEWLRSFFIDNIVIVITDIVNSTSQWNLYSEDMHKSIKLHNELSRKLIRTFGGYESRNDGDSFFAVFKDSESAIKYALNFQNGLLYQNWPDTIVNHNKELYNDSNTPIYRGISIRIGIHTGKCTVCCFDRKLKYFGKTVDEAYALSEMAKGGETFISNQVFKGIKSKEFISTFNVIQKRAYQEKGFYIYHPHHISRFLECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JW85</accession>
    <name>A0A4V2JW85_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2479p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002479">
        <property type="protein sequence ID" value="TBU06952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JW85"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2479p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU06952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="541" mass="63952" checksum="628D24757AA9DF57" modified="2019-07-31" version="1" fragment="single">NNFGFADLNENFFYLDTCILQKILKIHKQAKYFLKTLNIFFSLHVYKRFFLFIMSYTEEYKCFFNLSLFKNLEELFMFKCLNTKVFIANIIKTMHLQSIKILTVFKSNLISEDEIVWLKELNFEELNYIVTKYDSKTYFSISEFKSPVCIIFSKIIDAIFNNENKSSFYARGTNISCYDQDNEFVFVFYQDENRVKDLMNHGIACQISFRIKLCNMFINVIFDIINFKRLRNIEIEFTYTCIRDFSIYSSEILNNIVTMRIVSSTVNDVFLSKILLFPALKNIVFYVCTIIFLNNNIILSENTNIEYLNIADSLINNVNYFIDLMNKMVGLKSLEIFNMTKNSNPLEKNSDNIKLCLLKLTYLRYSSSYYSYNNALFFPFLPSLLKFNLGSNHPAGTLHKIFFNGNFYMLRKLVFYGIKIGQEDELALQKLTNLHSLTIGKNSEFSNINFSQMFHTAYTYSLTELILPNIEITYFDLKFISELKNLKKLYIYSFILRTNIIFFLKIISSITEIEIEKIFVLKNHIIEECGTRLKISAWHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWA9</accession>
    <name>A0A4V2JWA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subunit 5 of transcription initiation factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_2432p0010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002432">
        <property type="protein sequence ID" value="TBU07222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWA9"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2432p0010"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU07222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="566" mass="63649" checksum="6CDCEE604A9A9B82" modified="2019-07-31" version="1">MHSTDFPHKRDELNQLSSIRDPLHIRENTLAYSLRTNKYYLPLSKYAFDLFINFIEEQSLHYILKTVNQYIDIKVTLTPNTTLPGLLNHPISNTPLTLNTYLVSKETEEAILQDEQYKYDHLETFVTQLKKQRSEQTPLDTDKSLSIPTHNTPSNISSEIEKLKDLTKRVTVSKNTLPSICCYTLHNTYDQLTCSEISDNTQLIACGYQSGVIEIFSVNGTLYKLKSSSELETSDIREVIPKQKNSPTSTPVTENNSNINNLYTSLGNKNKLIGHTGPVFGTKFFSTNKYLVSCSQDCTVRLWSLEMWICVGRYKCHSFPLWCVDVSNDNFYWCSGSADRCVSVWNIKGVVRLLVGALSDVLCVKYHPNGMYIFTGSSDQKIRMYDVLEGSIVRTYNGHKDSVTCLSVSHCGRYLLSGCKDGSVILWDINTCSIINEYLGHEKAVYSVGFCYFGNLLVSSAGDNSVRLWDKADKVCLGTYFTKGTPIYCVKFGYRNIISCCIIGVNYIGSSIKGFNAIGSNIKGFNYMSSNVKVVNNICSNVKGVNYMCSNVKVVNYMCSNIKGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWP5</accession>
    <name>A0A4V2JWP5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2224p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002224">
        <property type="protein sequence ID" value="TBU08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWP5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWP5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2224p0020"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="217" mass="24510" checksum="17C65338C35C5500" modified="2019-07-31" version="1" fragment="single">CKISIEDQSIVFVDLAGSERGNDRKTVASNTKNEGAEINKSLLALKECIRGLDKKFKHLPFRQSKLTQILKNSLIGVSKTCILATINPSVFCVDHSLNTLRYAYRIKGNQKSPKKQISGAPQSFYDKIKNKKSPNKYFIRNSIENTLYRDSSSITTSSLSFNTFKDEIDDVNLAKKRVNCVIYKIKQAISTTEDISIVEVAYDGLIKIENQINDMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX01</accession>
    <name>A0A4V2JX01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_1763p0010</name>
        <name evidence="8" type="ORF">CWI38_0935p0020</name>
        <name evidence="7" type="ORF">CWI38_2103p0010</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001763">
        <property type="protein sequence ID" value="TBT98418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002103">
        <property type="protein sequence ID" value="TBU09862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000935">
        <property type="protein sequence ID" value="TBU12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX01"/>
    <dbReference type="STRING" id="1176355.A0A4V2JX01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1763p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0935p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2103p0010"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBT98418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU09862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="188" mass="22174" checksum="B7EAC377EBDBE288" modified="2019-07-31" version="1">MTVMTLISRGSSASTKHLMLDISKLTVSRRETKFDSKDELKELQELMDMNECDSVLYFHTTKRTLTTWMSYINGPSIKLTTFDYQTMLQLSFCTNFLKQGGHVLLFTQEFDEKEELKIFKEISQKVFVSKTEIDRVISFFYYNNMIWMRNYVVGDEIQEIGPRIVFQVEKVLKKCFSGEVIYNRSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXF0</accession>
    <name>A0A4V2JXF0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0766p0020</name>
        <name evidence="3" type="ORF">CWI38_1125p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000766">
        <property type="protein sequence ID" value="TBU01241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001125">
        <property type="protein sequence ID" value="TBU11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXF0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0766p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1125p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20181" checksum="14B09AD796068C39" modified="2019-07-31" version="1">MKKNTGIIASSFLLLLMVSCLFYSSYITFIKKFPITKKKIEKQLFQTLTHYLAEKENVDISLKESDYSSSRYKMVLFNVTPLHFICIIDNKKLISVDRNVFANHYNNDQDGCKNSEFMQIISKIFYICGFFCFGHFTFERVDDLVLFNDIVIENAGPDFFRILCFLHKSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXG1</accession>
    <name>A0A4V2JXG1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit SecY of preprotein translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1132p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001132">
        <property type="protein sequence ID" value="TBU11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXG1"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXG1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1132p0010"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00303">
        <property type="entry name" value="SECYTRNLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="3">
        <location>
            <begin position="2"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="48184" checksum="4D3CA039985BD529" modified="2019-07-31" version="1">MSSDTSDPLYWMRMMMASNKGTLMDLGISPVVTTSMVLQMLTHSDLLKVNYSVKEDRILFNASQKLISLIMTVGQAVVQVTTGFYGNPSSIGIPTCFLLVVQLIFSGVIVILLDELLQKGYGLGSGVNLFIATNVCESILWKAFSPKVFTTARGIEFEGSLIAFLHLIFIRRNKMAGFYEILFRKNLPNLSSLFGTIFIFGLVIYLQGLRVELPTESTQVKGVTGKWPIKLLYSSTMPVILQSYLVSHTSTISRFLYDKFPNFLLVRILGVWSVNENRRYVPINGLCSFIYPPESFTEALKKPLHFLIYLSFMLLSAAFFSRTWIDVSESNQFDVAKQLKRNKMTLKGVREKNVPEVLGKYIPTAAFLGGFFIGLVCVLANLMDTIGSGTNIILAVSIVWQYFELFTKENMKNGNIGVWIGGGVGKKGFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXY3</accession>
    <name>A0A4V2JXY3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0396p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000396">
        <property type="protein sequence ID" value="TBU13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXY3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0396p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6792" checksum="8A420184A86A0E6D" modified="2019-07-31" version="1" fragment="single">ETTEEIYFLKMKMFRFGDDNDLFYDVLQYTNNKDEEEICLNINLKRKRTRLFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY59</accession>
    <name>A0A4V2JY59_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0184p0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000184">
        <property type="protein sequence ID" value="TBU19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY59"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0184p0050"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22234" checksum="F53EAF0A84793D5A" modified="2019-07-31" version="1">MTQNHSTICISNFPDKVTEHQILEIFQHFGKILNVFSDINTIYITYSEYSSASCAISLNKTIIGNKKILVQFADESNINFKKNKKKIIDNHNLCSESCQNIENIHSDNKNISRYLVLNNFYDKNEPDSLIDLQNECLKYVNEICIQFENDYVVVECQNIKDAKKLFNVLHTRWYNNRRVYCKFKKSIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY69</accession>
    <name>A0A4V2JY69_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0161p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000161">
        <property type="protein sequence ID" value="TBU19973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY69"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0161p0040"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="892" mass="104425" checksum="205AB531143E5703" modified="2019-07-31" version="1">MARIDEAIFGKFRRNKIAHREVMKIEIINGFTIIKLCLIYIYPSILLRKCTCLQIEISFLNEAEHFCDRCNTTVENIDKSCDTCVGHKLATVMMPGFNVIGSSIDTAVHGALSTENSRNEALGTNRIDIEISGEKRKQDWFLPESDAIKTTLYGISGQYQIYNERISYDEEMQPLDLSFKKKQKTTDLSEFENKEWIKRTHTSIIFEYSDKFLIQNKYFNKYIDSELNHVKYNITDLTKTNVDAKTFEIFLFVLRFGYDKKCMNLKFDGFIIFLHLFYDLHCYAETDVILNLYKSLLPCLIIFMNDISIYIHIETPKNILSMEKYLFLPFLNVLFDKFEVKFNKNTNELSFLKRESKINLFLFEKNEIADIYIRTTPEVIIRLETESKHNLTIFYWLMSLFKISGIKISHDNIYYSECQEKAKDCKYENIAQELPSCELQLCELQILESIISRNNEEIKFLELERVNTSNYFLSYIRPFVKIEFLVFYKCKIPAYSKFLGQLYFLFPNLKSLKINYALLTTAFFKSLLNLKIESLDLSWSTFNDTKSKDLESSDGINTLCELKLDNAPLGFKVINLLLKSNSLKSLSLRNINFLYIRSTPNFSLLQKKYRFLDISKCVLNSSFMNFYSSNFEVISLSMQGLNWEDLLEMLTLDSLHVSTKALDLSKCCLNSFIIECLKKFQILESIKLSGSLRVEDVSLDEEYPFREHLISIDISDTKFLAAYIVFLNQFEFLKELILARCNLKEGFMSIILINSLYSSLEKLDISENQLGKEDLYLLSQIKNLKYLSATFENSIFINFLKEHDEMVFSQLNTLVLTKIYITIEIFQFIAKQFLLTHLSFKDCTFSDDFFPISITSSLKHLIQIHLINPSISFDNMRKFEDLIIYEITVIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA4</accession>
    <name>A0A4V2JYA4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0087p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000087">
        <property type="protein sequence ID" value="TBU20343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0087p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="186" mass="21656" checksum="905D2BA93BA62894" modified="2019-07-31" version="1" fragment="single">EIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGVTSQDSLQILGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKILEIPMNVEAYIRSIVLKKTVETISFDRRRGLESGLNAEENWERASIGVIMRAEMHEESTPPLKEEKREEDAAKNFKPKNKAPFILQGGTTLEELINNKIKNRIWKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYB1</accession>
    <name>A0A4V2JYB1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0079p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000079">
        <property type="protein sequence ID" value="TBU20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYB1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0079p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020728345" evidence="1">
        <location>
            <begin position="20"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="664" mass="78906" checksum="33589DF031E133F4" modified="2019-07-31" version="1">MKIRISILILLLNFAFLSQYKIQKRKNYDEGDNDFLVENRNTTEPLHNQRIYFSKNISRIEHNDFHIVSYPRNITSRGGSIEEIGQEGQKDKLFCYSHNSDPFCRHRKHMRDNEPFEYEQRIKKSQRSRDFPYKKSSVGDKNTDSVFENKCFCESRRESLNFDTEERHNKRHDKNFDSNREKCYHYCRYESDSNAVSTGAYLQSDNSLSDSKAACFEKTQLEPSNSFRSAKKNRSSYNSINRCPNNKSFNPDVNSFDEMIYTCGRIYDIFQCLDREYIEFSVIEDFIQGDFSINGYFLYTDYRPFYNLIDQIFAIEERFWSKFYAKKRIEYLAHEMNILLMNYNLCKSNSPLLSYFPGIVNIKYFIRNIILDDMDFVRNSCLWILLIKAAESLCNVQPDSILLNIRKKDTVIFNKYKNFNVYNGDNDAFRVLKTLFVIFYGIAKKIYRCAKISRKYFSMLEFVFNNAMYKSIDLHITFGCHVNFSRVIADSIFRMNPEMIISLISELKRQGISNITDSKSGNRINRLFKRLYVNSSVLKFNNQLDIECIYVNIIESYIDFFKTELLYLNNFRDEDSSYVRKDLLCIEDIVHQYKINNLLIRKLDLKILMEISEALCVIFNHFIKVGLNNMLYPDKYIAKSFFYCNKNIKKILIIFGRLTCLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF4</accession>
    <name>A0A4V2JYF4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein Rad14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0007p0040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF4"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYF4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0040"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="189" mass="22559" checksum="FB1FB8F51C3DDFD3" modified="2019-07-31" version="1">MKEGGFLLEKDEQKKIDPKKDKDIILPYENNTSCKFCSSLNIDDEMHNIFGIFVCRDCRYKELKFITKTSCKKDYLLTEEEISIFKYLVRPNPHKGNWSDMNLYLKNEIEAFSLNKYKSFELLEEEKKIRLDNRQKKNKKKFIGKIRDLKRRTRISKKEIKEEKHVHNFITVDGVTKCSCGMVIEMEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MV80</accession>
    <name>A0A4V6MV80_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1914p0010</name>
        <name evidence="3" type="ORF">CWI38_2467p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001914">
        <property type="protein sequence ID" value="TBT98081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002467">
        <property type="protein sequence ID" value="TBU07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MV80"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1914p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2467p0020"/>
    <dbReference type="OrthoDB" id="2191389at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT98081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="73" mass="8319" checksum="F1A2FB60174BDBD7" modified="2019-07-31" version="1">MGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3A9</accession>
    <name>A0A4Q9L3A9_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI37_0598p0020</name>
        <name evidence="7" type="ORF">CWI38_1442p0010</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FI-OER-3-3</strain>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000598">
        <property type="protein sequence ID" value="TBU01924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001442">
        <property type="protein sequence ID" value="TBU10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3A9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0598p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1442p0010"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU01924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="189" mass="23099" checksum="88CF3A1AB2642068" modified="2019-07-31" version="1">MKLYNINECLENNQENIQNRRKMYWKTKEALRRADRTKIDLKNIEMIELLLNIEKNVYFKEERQLETYPEFMQRCKSNFLKDFICCNNIFTDFDTYVMHVQKYHQTEIEAENQSSINNYENFQLLNYDFSNFQIPELNLLNEKPYFGIKKPYPCKVKGCYKSYKNPNGLKYHMIHHHSDILKDQKENYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L3E2</accession>
    <name>A0A4Q9L3E2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0572p0020</name>
        <name evidence="9" type="ORF">CWI38_0014p0050</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000572">
        <property type="protein sequence ID" value="TBU02033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L3E2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L3E2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0572p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0050"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU02033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU20870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="573" mass="68012" checksum="2185674C7998030D" modified="2019-07-31" version="1">MKLKNYNLGPVLGKGASSVVYLGIRKSDNFHFAIKLIPKTNETTKIAKQEIFALSRLIHPNIISLISYEETPSHHVLVLEKCTSTLQSLIENYKLPENSIKKIIRAILLGINYLHSMNFIHRDLKLSNVLIVNGEVKISDFGLSCSFNPTPNTFCGTANYLSPEMADNKPYDYKTDMYSLGVIISRLAVDFKNNIYLNDLIERLLEADSKLRISSDEALRHKYFEEFYIFINLCINYRFIEDFCRETKFGSIIKQDNLFKIDDIEIICNKKEEINHQKNFSNDSGISNFLNKKFYGTFIKSKLMDFLTNNKKNLKSQKNILLYDFEHKIILNGSEIESIFVLENRNLKKLNFLFSLLETMMKKTPLIVFQYHDYKFTYFMNRDWIYRKFENNFYKNNLKWEFICFKDSNLYINEIIYENFPDFIEDSILIDIFKLYKKCFELEKFIHIKKGIPVIIKDSENNNFSVRNNFDLKPSINKFSFLQNNFTERSTFNFLKEKTHYISEVGWCWYRNGEIFIFFNDGCRMEFYISSDKYKFGNCKYIKEYSLNSNIPIEQINYLKKVNIFLENVHKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L4B1</accession>
    <name>A0A4Q9L4B1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0592p0020</name>
        <name evidence="4" type="ORF">CWI38_0023p0080</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000592">
        <property type="protein sequence ID" value="TBU01945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000023">
        <property type="protein sequence ID" value="TBU20774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L4B1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0592p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0023p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445322" evidence="2">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU01945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="105" mass="9734" checksum="DC00A5CCFF41810C" modified="2019-07-31" version="1">MKSTKSIILTIMKVYLLGFLIAKALCGAGGAPPPEGAPPAGGAPGGECICGPSGCFPASDPDAPMKAGLAPPQGGSDGQAGPSGGPGGAKGGKGSNPPQGGPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9U8</accession>
    <name>A0A4Q9L9U8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0129p0010</name>
        <name evidence="2" type="ORF">CWI38_2007p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000129">
        <property type="protein sequence ID" value="TBU04488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002007">
        <property type="protein sequence ID" value="TBU10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9U8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0129p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2007p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="68" mass="8017" checksum="BFA9CA0D3C11E184" modified="2019-07-31" version="1">MGSVESTLNKKYPLKYEKKQENGNICAKYEQRIRDIKTQINSRNRNDSSLIHDEKTYIKLLKEVQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LB26</accession>
    <name>A0A4Q9LB26_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI37_0060p0040</name>
        <name evidence="11" type="ORF">CWI38_0515p0010</name>
        <name evidence="10" type="ORF">CWI38_0605p0020</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FI-OER-3-3</strain>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000060">
        <property type="protein sequence ID" value="TBU05009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000605">
        <property type="protein sequence ID" value="TBU12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000515">
        <property type="protein sequence ID" value="TBU13151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LB26"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LB26"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0060p0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0515p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0605p0020"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU05009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="146" mass="16112" checksum="F620C30592B70078" modified="2019-07-31" version="1">MALISPLNSFSKICRFYDSKVIDHFERPRNVGSFDKNDLDIGTGLVGAPACGDVMKLQIKVENNKIKDAKFKTFGCGSAIASSSLATEWIKGKTLDESLEIKNSDIAKHLSLPPIKLHCSMLAEDAIRNAVKDYIQKNKSKNTNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFB2</accession>
    <name>A0A4Q9LFB2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_2536p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002536">
        <property type="protein sequence ID" value="TBU06624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFB2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2536p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020782189" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU06624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="151" mass="16735" checksum="B9905FBAB0B4104E" modified="2019-07-31" version="1">MKFVVCFLVFFNFLAFGVLCASVGGSYKQPDDNPVLVSHKRVGTDYEPAIVSDSEKRELRVFEKTESEFSETGQAKPKEKGDETSQIVSNGDVPHRESDEKKVGCFGRCFGKKKSRVKANPKPSTLPPSNLSEESNPVLKSRNSCDVIDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LI34</accession>
    <name>A0A4Q9LI34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2141p0020</name>
        <name evidence="2" type="ORF">CWI38_2398p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002141">
        <property type="protein sequence ID" value="TBT97667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01002398">
        <property type="protein sequence ID" value="TBU07446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LI34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2141p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2398p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="173" mass="21326" checksum="319191D1B9D1D7D1" modified="2019-07-31" version="1">MYIKVRNIDKIINHFRIIEIFKMNTKIYYRKYFLSSKNQTEYIFLYKNISEIYLAELLTNTILIQKIEVKIVFEEINQVRSTYNIDKECSTLVLYSMKDIEIEILEKYFKKKIIFFSKQNTTQNIFYIFIEFEDNIDFPKILNQGYIYIDTLRIKIYYFLDYLDHIIDINDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIS2</accession>
    <name>A0A4Q9LIS2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2309p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002309">
        <property type="protein sequence ID" value="TBU08078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIS2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2309p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="158" mass="18200" checksum="6CBC83D91E79FB22" modified="2019-07-31" version="1">MEENIFKLANTDKNSNVQLQFGGYFPLETKINLPSENSLSACYCSYREKVSDNALNQHPKLHQKRSTVTAKNSKSNKDSKSNNETIKTSIDPNDKTFEDTRLNSYKPKISNREPIQQILETKSEDSKTLGDEKKESIKIFSESLKNEIIHENYNNMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LJD4</accession>
    <name>A0A4Q9LJD4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2407p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002407">
        <property type="protein sequence ID" value="TBU07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LJD4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2407p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="115" mass="13788" checksum="97155F21F7F5F194" modified="2019-07-31" version="1" fragment="single">MPILARLTDKQKFSFYKISKNGEKSFITEFDTSNLVEDYFINNKGQLFYIMNRSLYSTEGFIKKMDEDRYEWYKGKEKSYLFYISNKILWKIELTIQRNKTGLDSVNSPIFVCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNA9</accession>
    <name>A0A4Q9LNA9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal recognition particle GTPase Srp54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2101p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002101">
        <property type="protein sequence ID" value="TBU09869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNA9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LNA9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2101p0010"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 subunit M-domain" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU09869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19296" checksum="7B62AE1036346F25" modified="2019-07-31" version="1" fragment="single">ETVKKLNIDEKEMMKKIGSGNFTLGDYYDIFQQIMSLGPMSKMLSMIPGFSNMPIPDEKDFRKMIYIFDSLTEKELNSDGSFFEKQPSRIFRIAKGSGTSVENVQNFFVQFKTINSVMKKVGNNPGMMDLFNMDPTKMTTTQKAKLRQKANGVLPKDMVDQLNMFLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP35</accession>
    <name>A0A4Q9LP35_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1962p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001962">
        <property type="protein sequence ID" value="TBU10178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP35"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1962p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="581" mass="67917" checksum="12CF3CEC2849274A" modified="2019-07-31" version="1">MNLNFSLFLIQRYFNAVEASPDRKKVKISAHEENSFKNHETHAIIDGIDYLRFAKIFSNQTKPIKSSNPIEGAVSSDQSEISNATGSDSRTYIAESQYTELDNFTEVNSYEAMSQKESQFEFSFDDVSSYMELNSTDKVQEFHCKIYPNDFEVNRSITSETNTNRTSLSIHQTIEKNDAVNDSSKFNLEFQSKDTNGSDNWKEVVNKLFIKGLIGNSGSNMREELISIKNSYSNLSTSEIMRKIDGYHLINYANELRKTKIHLIVPELNYLLDSFEENIIDNILHGNALLIHYYYEITKIIINLILANSNKFDINIIRKNSRGNEKMEGKEEKSGKISKEEKKKKTLDESEDVRLLDIRRIFFIKRLLSELFPLFQYDSVKIEIYKTLNLLYFISHFIHLSRSYLRKYFFRYKMNFLFRFLFDSNINFKNDFNKKLIEDILGENENGTNPDLFIKSKLTALFRDYFCLDIFFDKGIAIIETYKVFAIAKDKDKVVTKTNIIAKLKKDSEQNLLENIDAYKNRKINIFLKLEFEINHSEYLVLSTTISIMNFYKSRGPCEISKKLLEESNKSLEELKFNKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPD3</accession>
    <name>A0A4Q9LPD3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1882p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001882">
        <property type="protein sequence ID" value="TBU10279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPD3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1882p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020794354" evidence="1">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="47971" checksum="95B99243072E33F5" modified="2019-07-31" version="1">MVVLSFIGYIILLTCINRTFGSISDTTQVTEKSQDINQPGDRVCKKIDIEKFTESNPTTTDINQAYEENDRYVEDNKKNQVLELKDLICMPNDETNSPKNNITRNTYNHFRAIPAQNAYLFERKYENPTEFYNEQVYQNQTARSFYMYSEHPNEVSHLTSNVYTGYVYYAPFQSSSNIRSAEGPKAFVPCIQTDRLLSENEIVNCLFHRLNSLNYFRNFRDFLPLIEYHYRFKNIKNASAVILHSRILDNIRINEIQIKGFAKTTDEERLRIWSLFTEKYSKIKMIDYDSPLVSFFPGIKMLKDFIYKLLLEKVLQDRNIFNIFVGMKMIESLLFSSKEMIAGLSKENSLDIFSYGYSITNIIIAHKRIFFTILKKILFKNFNLSKNFIISLRITEMGCVYLMTINYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPF8</accession>
    <name>A0A4Q9LPF8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1929p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001929">
        <property type="protein sequence ID" value="TBU10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPF8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1929p0010"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="130" mass="15350" checksum="458D510D2DF5E003" modified="2019-07-31" version="1">MKKTKFISKPTHFLCNAFEIEDLNEFKSLELNANSFYCYLYLASKNLYSLDLLPIFENKREKLKLLYNYIHYKGGNSKSTDSVNSTGKKLSEKDVKTALKLLKINKKFDKKPNKLFERRLKLFIKKLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPL7</accession>
    <name>A0A4Q9LPL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1772p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001772">
        <property type="protein sequence ID" value="TBU10423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1772p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6561" checksum="85AA920347B233A7" modified="2019-07-31" version="1">MSNSGAIFALNIADEKKHPYTGCYYEQDKIHWGGEFIFNESLKVYLKYEIKRDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ33</accession>
    <name>A0A4Q9LQ33_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1853p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001853">
        <property type="protein sequence ID" value="TBU10317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1853p0020"/>
    <dbReference type="OrthoDB" id="2196372at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="517" mass="60948" checksum="3F1455F531230602" modified="2019-07-31" version="1">MDYLEISNKTRDLEHKYNSLLINRLNKEKEILKDKITHLKSKNTEITDLLLQTQETLKISKEEIKSLMEVKEKILKNNLNLENTKKEENLRYVLGGEENKKIIKELQKEIENLKNEQILNKRIKEDLDLLKIENSKIILADSSLKAKNTVLENEILSLKNEKNKFFNEIISFKDKIIRMERNIEFYQNENKENESKIKNYEKDISELRNNNKFSVSKETIKKLEILENENNELKTLKNIYKEKDNLLNSLKENLKHKEEIISLQREVLNKYKNTDEYNQNGETVSLQREVLNKYKNTDEYKCKENIEESKEVESESLIFSPLNKFKNLESNYLEKKEFKKSILNPKKPNSKKNKDLEKENKNIFTDEILPKNKTINKFKEGENKKKSEIKKNTVTFKEPENTNKKSILNKNSYLKKTPLNSTNNLNTKLPSISSSPFSSRKPKKSVIFHPIKKTSKARLLTQKEEIESDFIVNSKENNTKQSNENVSLSQPIKLENSSFFANLTFTDSSPVIKKHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ78</accession>
    <name>A0A4Q9LQ78_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E1-E2 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1639p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001639">
        <property type="protein sequence ID" value="TBU10629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ78"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1639p0020"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="197" mass="22049" checksum="89C2FE5855016DB6" modified="2019-07-31" version="1" fragment="single">CFLCFNKKGKCKANYFTIIRGILIGFYIGIGGFLVYKNTLQNIFYNTKVKENPGLALTFILFSEMVNSLNNIDLNESIFLTYQNNFKVVGCVVMCVSILIGAIKHGRICGYMGIENVDVSEALFVLSLSFGVLVIDEIMKLSLILIKITLQESLQIFETGKLLLYDISANWLGLIYKCSVAIIPHAKSKILLQLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQK6</accession>
    <name>A0A4Q9LQK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1529p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001529">
        <property type="protein sequence ID" value="TBU10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1529p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="55" mass="6540" checksum="AE5268D2B9DD1102" modified="2019-07-31" version="1" fragment="single">VIEQNKNTDSRGYNVHRDDEVAIDFSFFIMMTCNPKYAEICENLDKTEKRKNRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR0</accession>
    <name>A0A4Q9LQR0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1592p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001592">
        <property type="protein sequence ID" value="TBU10714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQR0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1592p0010"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="169"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="369" mass="43781" checksum="579F738DDFB0FF6A" modified="2019-07-31" version="1" fragment="single">NAEKKHNKTKATPFTSNELLQLMSNLKKTSSKQQNILPVYRHLQCHIENHSQVRKECKNTNSCFQIVKKESLVFKYNINNNYLYALIENTYSRTNIDQKNKITVQNIQKNDRIQYKKPIKALEFKPENKIYYSKLSNDEKESLKKYCRYMLREKPKKSCGCIINMIKGFFMEKNRSDVANKKYINPFIYNVGDYILEEGIKTEGIFRISGRSSLYKSVPYSLKENCGYETSEYRIHDNASIFKAYIRDVLNGLVPEFICKELLETFKGSRNAKSIEEIVKYTIFCLDDMERELLLYLRRMFREIENYKDYNKMTMENLVKIFTPTLFPDFKPFDLTMIDKQIDFIKMLFESDFEEVPIDLLNAAHPNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQR5</accession>
    <name>A0A4Q9LQR5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1489p0020</name>
        <name evidence="3" type="ORF">CWI38_1532p0010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001532">
        <property type="protein sequence ID" value="TBU10818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001489">
        <property type="protein sequence ID" value="TBU10894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1489p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1532p0010"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="16630" checksum="5E948996CA69A3C8" modified="2019-07-31" version="1">MNDKSLKEIYNFLKKKKKVLNREDIRKFLIFLFPYKEREIIYETIKKETKDTYTYEDFKEFWIKKIEKPEEDVINKIFYILDRDSDGYISYEDLRINFLYLGFSVDKTILTKLFSIFPTEKKSINLSEFRNIIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQX9</accession>
    <name>A0A4Q9LQX9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1457p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001457">
        <property type="protein sequence ID" value="TBU10963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQX9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1457p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020599241" evidence="1">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="28350" checksum="FBD9BB08E9627A5C" modified="2019-07-31" version="1">MKRNIKFTIQILILSAFVKLTTLEHHKNYLTLFLNDICELSIKEENIEITENFYNRNNMIFLILKEDNNSYYLPISESFEGDNEQIYSNEIIMLINSIKYKDTNLSVKNVLEILVKNKIFIFPGLFELEKLKEYVLKYEKDTFQHDRSLRHGRSMVLKFIREYIGRIDNFISKSENGIYFIGHNFRKDTISLNMKSFFGESEVNDTITIIECENELKHINIEFKIFFFVFNFKIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQZ1</accession>
    <name>A0A4Q9LQZ1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1447p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001447">
        <property type="protein sequence ID" value="TBU10983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQZ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1447p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="71" mass="8307" checksum="E9EB280D0FB58904" modified="2019-07-31" version="1">MHDEPTPPLKQARGTTLEEPAININEESDLEEEETMMFKEVEGNYKSYREVLIQNFIKKVYLLPDLNPKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRZ4</accession>
    <name>A0A4Q9LRZ4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1881p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001881">
        <property type="protein sequence ID" value="TBU10280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LRZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1881p0010"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1540" mass="175372" checksum="C1756B875CD10ED7" modified="2019-07-31" version="1" fragment="single">NNTTTYHPVNNTNTTNINLLLEKAFFILKRLVYLKWKYLINNTLIDTFIETVRILEEKFYFLDFLIKKMNKHFIRIFNTQITKNTLSFSFNPLYYIKYFPCYYDTSIVIRSIEISFIKALFQYFKTIKYSLVNKRCYLLKSVHNICLDTLFIEPSLEMCFNIYSVIFKGSLLTKIYNYYRGVKGNDGLEGVNDKDGFEGVSDRDEGYRGVNAIGGNIMGVSNNVDNYQGVRDKDGLEGVNEKDSLEGVSNNVDEQQGVNDKDGLEGVNDIGSNIMGVSNNVDEQQGVRDKDGFECVNEKDSLEGVSNNVDEQQGVSNNTNKQQGVNYNVDDYKDVSNNLYKQHPLINTLIEEIIELVLMGYLQCKDNIEFLRNEVLVNYSYFIEVESQMNKILLKDKSNDNTFTTSTYTPYINTPLSSNTHTLYSNTPLATSTYTPNINTPLSSNTHTLYSNTPLATNTYTPYINTPLSSNIPLPDILLIFLKGVNDLRIILDYLSYINKRCYLYNLINNNEIPLFTFKILNNKISIKECYKNKNMFINRSVNTFIVIYNTLESILREITYEPYNLYVLYDLLEIEDFIYKISVIKEVSSVIIKEIKSGVSDSRDIVEGVNDRRDIVEGVRDKGVLEGTKGVSYKEYELKGVSKGTDNYNPVNNLSNTQHPVNNLSINNNILTDNTHVLFINKYNTINTLLITISNRIKMEKKRYFDLFYNNSSNVDNINVNDNTPLSNSNADNTPLSNSNDDNTPLSNCINPNTPLTNCINPDTPLTNSINPNTPLSNCINPDTPLTTITTNNTPLPNTLPTINNTTTLSLPYINTLTFNTTTSYKSIINTLFTYNYNTINNTYEFLYKLKDNLLVLEYKYLIIKKVRNFLRLEEYLLIYRNIDFNTLKYFIYNIYSFIVNIKNKEEGLNEYENNSLRHVSVNYMKGICSDMYKEIKGMGLVLDSGEGVSDNRKGVNSRDRDSREGVSDNRNGFSSRDSREGVDHSSSNYKGFSKHSSNFKGVNDTSSTYKGVSESTYKQHPFNNTNIEQHPLNNTTYKQHPFNNNNIEQHPFNNNNIEQHPFNPNLSTILNNISLSLSFINLRLLTYFKVLEYLNTIINTNIGIRYFNMNMSLKCFISIFNEEVVNKIITYYKVESDINSYKRDVNLYISNVVLVREIGIEGVSNKVCGLEGVNDNRMEVGGVNGTRMNVGGVNNNRMEVGGVTNSSNNYRGLSNRECGLEGVTNSTNTYNPLNNNTTYNPLTNTTISYINKICNLKEIEEYLDDLYVKGEGLEKYIFKIKNELKGFKEEVLYSYNKEGGYEVGGVSESIGVGGGVNESIDDYKGVSSNTYSYKGVNGSIDDYKGVSNNRYNYKGVVNESIDDYKGVSNDTNEQQGFNKSTNEQQGVNNNTYDYHPVNTNINNYHPVSNTYNNSLIDSLFVSLRNTLNTLESYLYIIRELKGIQSTLIELYSILKNNTLETENINKIIEVYNLIGVSDRSILEGVNNNMLEGVGDSSILESVNNRNMLEGVNNSSKQQGVNNRNMLEGVNNNSMLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS02</accession>
    <name>A0A4Q9LS02_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1262p0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 10"/>
    <dbReference type="EMBL" id="PITK01001262">
        <property type="protein sequence ID" value="TBU11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS02"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1262p0020"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="762" mass="87558" checksum="920DC5A4D1522F58" modified="2019-07-31" version="1">MKVQKRNGKLENIDISKIERRILSQLKNEPIHINFEELVSKVSSGLCTNIKTSEIDEFTAQMCASLTSVHPQYQTLASRICISNLHKQTFNTFSEKIEFLYKNDINISKDFLDLTLKYKPKIDEIINYERDYLINYFGYKTLEKTYLLKTDRLVERPQDLFMRVALQIHSDDIESAFETYNFMSQKYFIHATPTLFNAGTTRPQMSSCYLLSMQSDSIEGIFNTVKQCALISKNAGGLGMHIHKIRSKDSRIKGTGGTSNGIVPMLKVFDSTAKYVDQGGNKRPGTLAIYLEPWHADIFAFLDLRKNTGKDEHRTRDLFLGLWIPDLFMKRVKNDEQWSLFCPNDVLGLEDVYGDEFEKIYCKFEEEGRAKEKIHAQVLWRAIIEAQIETGNPYMLYKDTINKRSNQKNVGIIKCSNLCTEIVEYTSEDEIAVCNLASIALLSFIVNGAFDFELLIKITKIIVKNLNKIIDKNYYPVEEARTSNLRHRPIGIGVQGLADTFAILRYPFESEEARELNKKIFETIYFAALTSSCEISEKDGHYLSYEGSPISQGILQFDFWNIKPTNWDWDSLRNKISKFGVRNSLLIAPMPTASTSQILGFNECFEPFTSNIYTRRTLAGEFQVVNSYLLKDLIDLNLWNYEMKNSLLQNEGSVQNLPIPENLKKLYKIVWEIKMKTVLTMAIERSPFIDQSQSLNLFIPMATYGKLTSMHFFGWENGLKTGMYYLRTKPISSATKFTVDEEMINESKQSCKIGEPCDSCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS25</accession>
    <name>A0A4Q9LS25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0581p0010</name>
        <name evidence="3" type="ORF">CWI38_1404p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000581">
        <property type="protein sequence ID" value="TBU01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001404">
        <property type="protein sequence ID" value="TBU11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0581p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1404p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="403" mass="48262" checksum="767A870705069000" modified="2019-07-31" version="1">MNKDMKIHSFKSLLKIFPLVFILSCFFNAINNLNFIQILNPFRTFPIRIIISSIFYLTYQHFLNTTVPTFSYKNVYFVTQLTLLFISHLFYIPPYILKENIFYTIILISISTPLHHVSFSLIYTQNIGLFKYLQKERKRIVMVTVRNTKILFISFFTLTFIISVYNSLIYISLIFLIIFFMNLHFYITNTLYIYTYSLFNKSLLSPLSISYISNPITQIRRFYFNQYLQQSLTYNNVYLSSKISENIILFYKIELQKCITLLSNLKNVSNNFNMSKYTLIPLVIKKENKIFEKNNSLKESKDMVFIKKVRKWNFFNIFVEYVKYRIQLHFILQEYNGCIFYLKESLVYFKKMRKEKDPFGLVDVFIKDVKNSMSVFFETGVAVQEEIKINLSVSVLFKDYEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS68</accession>
    <name>A0A4Q9LS68_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1691p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001691">
        <property type="protein sequence ID" value="TBU10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS68"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1691p0010"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="70" mass="8374" checksum="8B30A4E1EE7F72FC" modified="2019-07-31" version="1">MAKVVSLNRAGKVKGQTPKVEKQEKEKGKTGRAKKRMLYEHRNRENEDESSELNLYLIFYWYFVFVLLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD9</accession>
    <name>A0A4Q9LSD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">STE-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1186p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001186">
        <property type="protein sequence ID" value="TBU11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1186p0010"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="171" mass="20191" checksum="8B80A96AF0D98528" modified="2019-07-31" version="1" fragment="single">MNIQGDKDLFTFLSNAPKEFREGEKIKKYQLKNGDYIHCVLWNMHFYITGTDIVKILVWRFQNAGRQLVSLKKFEEGVFSDLRNLKPGIDATLEGPRSDFLEFLYKNGCIRTQKKQKVFFWYSVPHDALFCDALERDLRRETNLYTYSKYMNNLARQNYIPMPTYSNGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSG5</accession>
    <name>A0A4Q9LSG5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1186p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001186">
        <property type="protein sequence ID" value="TBU11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSG5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1186p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="13082" checksum="AD158CFC6C7EBBFA" modified="2019-07-31" version="1">MCETCHGDVRVIKRYGLENGYGLDWGMGDRGMGDSGMGKGNSGMGNSGVSNRGMGDSGMGDRVIKGMGDRGMGDSVLVIEVLVIECISNRGVSNRGMKVWVIEVWVVIKGMGDRGMGDRGMGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSH0</accession>
    <name>A0A4Q9LSH0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Large ribosome-binding GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1314p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001314">
        <property type="protein sequence ID" value="TBU11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSH0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSH0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1314p0020"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="304"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="495" mass="58831" checksum="FF66A3A749393638" modified="2019-07-31" version="1">MHKEKLGQALINRRFGQKNIKKENKTPFSVVDQANIDRLFEKLEISKKDISALNSRNIQEERTEEPLDLIYKRCVEVFPLNLSIPPRVNFTEKISITDFQDLEKRIFNKWKDEHKNVIFERNLEIWRQFWITCEKSDVIVQIIDCRNILFFFNKDIINMYPKKKHLIVLNKSDLIKNTEQIEIQIKMLIEEYSKEYNKENSRENSKENKENYKELSKEYTKELSKDEFNKDKYSTEENIKEYTTDNHTTDKYTTVNHTKKEDIKSPSNEIPNVQWLVFSCQNNKYLEDLKNIFIKYNETGNSTFGMIGYPNVGKSSFINTLLQIKKVGVSKTPGKTKRLQSLNFNLNNIKFTLLDCPGLIFPTHQKTSLILNSILNVDQMKDLIKFSNQIIQHFGIKRLCKFYNINEFKNDSRYDINTNFFNQMIKIKNIDFGKCIKKIVKDFIDNKLTLEIEEQDIDLTINYDWYGFGDKSKSKEIKKGKKVYKKIRRHIILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL3</accession>
    <name>A0A4Q9LSL3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1710p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001710">
        <property type="protein sequence ID" value="TBU10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1710p0030"/>
    <dbReference type="OrthoDB" id="1304783at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="87" mass="9878" checksum="58FA197E93300A18" modified="2019-07-31" version="1" fragment="single">LQHEASPHTIDELINCVQDAFHQLEANTLDNVFTTLQACMESIMLADGGNGYKIPHISKGKLRREGRLLEKYVRSKESYVKAKSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSL7</accession>
    <name>A0A4Q9LSL7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1134p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001134">
        <property type="protein sequence ID" value="TBU11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1134p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020640321" evidence="1">
        <location>
            <begin position="24"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="657" mass="77394" checksum="502DD4B403A83582" modified="2019-07-31" version="1">MIIRTFKNIFLNYFICYLKVVCLSNLDTNCYFKQDNCTFAADNCNGKNYDKVLDLYTRPIPISDPSRYFPSITLSNRFHPYNLPRKSQEKSIDITKHISHNDQFNPQKLPSCLYSSYISSQNISIDDDLPRFDLAFCHLIESNQSALQNKDVPNLESTAQSNILLHQEKQFLFAQQYQLLPENSDKSNTKESESCVSDLKTPNALSSLINFHDEFDYKGTISYLEFLKKITLHNATPKSYEEQYDLKRAKKRLNLLLSRQERYVATADNKSLLSKCEEGDKLNMICNKYHNYTREYSMTRWKKIGIHIFRRLKSIQKEYDSILKSFIKLEEFVINSKEKNANDIVLNNIAKMNLAEIFIGELHAHSYKDLISSNIKNIFDNIFLKNKPCIWETQSNAQRLTYTVQELEHIFSYEIANLKSQDTDISNVIKVCWYFVDYEKVLFQDMDINMILEALNLPKMTETLVKLNECMKIDLFYEILVLIERYGKNLEQIIKKNHVVSTVFLLNALVINFQQINYTHSQSKSYEDLYKTSKVKINADIFYRGKLFEELLRNLENYETIANLYGMLNTCRFILNLVISRKSRSTLFFLQIPCLIAMILDESFISNKTQTKEFFAFILLLIKKKEIIYRQKEFYNDKIQYFFETNSPIIDKLAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSV3</accession>
    <name>A0A4Q9LSV3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_1538p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001538">
        <property type="protein sequence ID" value="TBU10811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSV3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSV3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1538p0010"/>
    <dbReference type="OrthoDB" id="2187328at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU10811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="423" mass="49716" checksum="88A07112A535BB5A" modified="2019-07-31" version="1">MTNLSCLGENCTIDFPKEIVSCNLEQNYTYIFSEKIAKRTYSEVLMYICTNTNQKVAIKVKFSANTKDSKENIALKSMNHPNIVKYIDSLVIGGYECIIMEYVPYTLIKYLNKNEFNFMNLKIILKQILDALKYLEYIQVIHINIKPNNILLDENLNVKLIDFGICCTIQDKSLNFSIDSNLKKALKKFPQIAPEILSGQVFDNSADIYSFGYVCFFIQKKFIKNVLCDEKNKKSNDLLSNLIYNSYCSSRTNRSSIRALIFHPFFDELYEFLECFCNFDNIKPNMGDIEIWPYDGKIHIKKDNIEFTLYCSCHDKLDLDRNLEYIRIQKTYLSTFSFYNTTNVNINKFSVKIRKILLHIKFLYKEDLLHIIKAFEIIKKSRSRLSDKQMRSEYNQSVVEENRVRSENKCSYWLRGLIRSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT58</accession>
    <name>A0A4Q9LT58_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1037p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001037">
        <property type="protein sequence ID" value="TBU11793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1037p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="360" mass="41942" checksum="08E7C875F3D04452" modified="2019-07-31" version="1" fragment="single">MNNIELKTNKYKSATNNPICEEIATFCEEPVFTNALLNDAVCVVMVKNKIEFRPGCKEALYLLDKEPEVIYIMLRPLDIVVFCQSKIETYSGVEDVCQHCNTSRESVEHLATRCITMPCYDHTKRYNNLYDAYIYSYRSDIILSFQNELYHSIQKILDNKQYEVLENLLGLIYKCTVVIIPYGINWNGIDREISKKVPGIIERGVWPGKKDFYEQLKSKKIGHKQVNLKNIFALILEGFYSEDCLNGFMPNSSDSYPLESNIKENSGNNDQKLIFQSTHYTLDLNNVQIFENEQNEDRNMEKRYPRLYTYPKLLKNTSDNSLDEISSTVHFDSHISHDTLQNYKESYDFKLDCNLDDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTD0</accession>
    <name>A0A4Q9LTD0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_1436p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001436">
        <property type="protein sequence ID" value="TBU11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTD0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1436p0010"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020338008" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="35930" checksum="15CE22364A0B63E9" modified="2019-07-31" version="1">MLSLILSILLLINIIQAECVGQAIISYDEGPTDKIEKILEISENLNVPIVFHFCTDSLKKNLDVFKNIKDKNVEIGISITDDLYALDIDLIKEIIISRKKEFEELTGYTPILLRLPRSFHPSESKQIAEDLGFIVTDPLIDSEDVETPNYICLVKNEILQLDKNIENFSIVFRERIDTSVSELENFIEMLKHKEFTLTKYSTLLNRNTDLIPIIKKNEEDIEEEEFKDEGSKKAKNNLEKSEKNKNGDDKVKTDESDDFDPVFPNPGTNVDSESNIEESDSLVQAMDSNNEKNSCYGMNYINGFLFLLISLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTK7</accession>
    <name>A0A4Q9LTK7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0965p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000965">
        <property type="protein sequence ID" value="TBU11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTK7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0965p0030"/>
    <dbReference type="OrthoDB" id="7976214at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="148"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="261" mass="29790" checksum="B2D5161535255170" modified="2019-07-31" version="1">MSNSFSVETPECIECENDNVLKCLVETSGSYDENLALTTIPTLKKQIDSINDRERIIEKTLEGYSMSAIASMKRSGDYAIKFAEWVKCTFNFDVSTSTIDRALREFHYTLKQATEVPERRNTLSTIELGTNYATSFRELEVDNDDKNLVFLDEAGFAVVTRPSRGRNMRGESAYLSVTAARSKNISVVAAMNKYGMIYHKIHEKAVNGEDFKLFIKEINESCQRQGILTSIFVMDNARIHYYRGLNDDEEITSYRIKYLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTW5</accession>
    <name>A0A4Q9LTW5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3441 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1415p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001415">
        <property type="protein sequence ID" value="TBU11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTW5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTW5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1415p0010"/>
    <dbReference type="OrthoDB" id="2187858at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT protein C-terminal" evidence="1">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="429" mass="49888" checksum="701B2AF701E2DE20" modified="2019-07-31" version="1">MEENKKNKGRVGIKEIGIDEMEENKKNKGRDEIDKNTFKNIQNRNIIRYDDFIFVTSLFGDENVEYCFPYCAPWKSLRNNKFKVRLLPGNVKKGKLIKEVVGKFLGQANEFEKGFIKKVGVEEFMEAIFFGLLKISGQSEIKSKIRIAAEQCKIATFLAETCTLTDTTERLKFEMYDPNSKSSKSIVDSKILDLKNRLENIDSKICSQYFPKIFLESSSVTDLSVALVENNESLNVYKKKITMHESRKKLQRENYMLELFGVEYIEFYMSMFNRSIRSVVMKLNNIGLEINTKKQPQMMLTQLEQGDFSNLDDEKPALRNINSKSAILEILNADEIPFAYIKSFMKVKYELERKVIKKNSMKLNLDKTVFCYIQDKNVFCGQIICESWERASMDVIKRFEIHKELASNGVQKVEENIKMCGEIFKQGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU53</accession>
    <name>A0A4Q9LU53_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1064p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001064">
        <property type="protein sequence ID" value="TBU11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU53"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1064p0010"/>
    <dbReference type="OrthoDB" id="5592268at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="68477" checksum="52485C2ED1327F99" modified="2019-07-31" version="1">MQELFINRCESEKNDEIFEFINSMPNLKSPKLTPNNNISLFKYVFKYNMMKLKNLEKFKIKDENKCDKGYSDSLYLEKIIELEINCLFEQSFLYTLFLNQKLENLEKIHIYNCNIGLKDKNSRRNYTRIQDILFSNTKLFGISFSELFDTQKEYSIKYICIFDVKLSKRDLMFMSNLKYLEFSFFGSIEEMFDCKDWFRYFRLNPLKVKIEIYFANIDPIQSDNGRDFRNALLEAFLTDHNIKIIHGRPRNPKAQVKKLHETGGRKWIKHFNNAVCAYKRTINSATNKSSFMLFFGQPGFNNPLSRSIIVENEASLIVPAIDIDPDIALSLKIVSDVHEEFTKTVTPTTTTIADDLETIHFKNYKERIIESNNSNRIKEIWLLEIKALFNSYDNSVFKITAILMNNMIEVKNNDSTDVVMGSKKYEKKDQCYDQECVDVIKNRNLDSLKALQEKTEKYAQETKEDYKIRELEKMAGNKEICKIYKNIKNEIRDFQARNMMAESTEWFLLTDPKKKFMKENNDHIEDGETNVLEPTVAETTDDIMSLANNNAPGEDKLTAKPLKYEGDFSENDFYNLIEELWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LU87</accession>
    <name>A0A4Q9LU87_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1048p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001048">
        <property type="protein sequence ID" value="TBU11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LU87"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LU87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1048p0010"/>
    <dbReference type="OrthoDB" id="10532113at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="115" mass="13335" checksum="084A267921A907EA" modified="2019-07-31" version="1">MLGLIYKCSVEIIPYVMTWDGIKLQIPMNVEAYIQSILPKKTVETISFDRRRGLDVILGAEMHKQPIPPLKQVDNEEDDVKTENTKNILPLILDGITKAKEPTTNTNEEWKWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUB8</accession>
    <name>A0A4Q9LUB8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0835p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000835">
        <property type="protein sequence ID" value="TBU12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUB8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0835p0010"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031544">
        <property type="entry name" value="WD40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17005">
        <property type="entry name" value="WD40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="323" mass="36847" checksum="7B26E6E329599BAB" modified="2019-07-31" version="1">MKFDENNTEYNLSKLDEETYENKIYAIDCNIDRSLMIFGGIKNILWIKHSQTEDITSFEKYSDSVIFCKFVDKNTFLVAILNGEIYKYTLNRDIIEDKSFYNLNNDISFIEISSSDTEILIGTITGAIHVLSIDLLTEHVYLGHKDEIVSIQKYDDRLYSLSDSYFIIFNASTYKSLMHKQINQGYSMSVLGNRSICLCDASGIQIFRDNTTLFNIRDTGRTESIALSDNLTIVGTDQNIFFIFYNTTFSYFTVNVGVNKLSIISDYLIASSTNSEILVFSLSDIQSYKVYKTDVDIIYDFVVFGNEVLIAGDSGISSIEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUC9</accession>
    <name>A0A4Q9LUC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosducin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0269p0020</name>
        <name evidence="6" type="ORF">CWI38_0517p0020</name>
        <name evidence="5" type="ORF">CWI38_0830p0010</name>
        <name evidence="4" type="ORF">CWI38_1862p0030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000269">
        <property type="protein sequence ID" value="TBU03597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001862">
        <property type="protein sequence ID" value="TBU10308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000830">
        <property type="protein sequence ID" value="TBU12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000517">
        <property type="protein sequence ID" value="TBU13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUC9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0269p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0517p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0830p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1862p0030"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU03597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU10308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="145" mass="17049" checksum="89754453F2565A8E" modified="2019-07-31" version="1">MINNKNEEIDSDEIEFIKYKNQRLQQLEKNRIPTLQSEQDLINLTKEETMIVHFFDPKFKRCDQMDKALNLVYLKFPCIQFYRIQASLASFVTKRLQIVALPTLAFFKDGYFVDSVVGFENVGNEKLDLEELNAYIENSPITKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF6</accession>
    <name>A0A4Q9LUF6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0816p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000816">
        <property type="protein sequence ID" value="TBU12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0816p0020"/>
    <dbReference type="OrthoDB" id="6918874at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="64181" checksum="E6623F5DE16C64D1" modified="2019-07-31" version="1">MTEYDGVFIIQPIKSAEYNKNVIAEIFRNYNYYFYLNLVVILEKKDILLMKNSIICDEKFIKKYIKHYFVVSLPFEYVIRLMDKTKDKIQKISFLSFDLPVQIHRDLFINAQTKSSSRIINNSRTDYMDKILYLCIDKYIVIKNHKILVLQKKVKELNFYHIFKNERINESYKITQTCFFNLFLYTVEIKRSIHFSSFKLKDKTQYDLKITIKKHVNLDPEVLMVKIITSCDFSKDYYDVKKVLLNLMARNPSGPRNEAVFCYIQDRNVFGGEDGMSQHCNKSGKTVDHLATRCGKMLGHEYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAKIRVYIRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVEIEKLRKYDLLANKMGLIYKSSVEIIPYVMTWDGIVTEYYRSHLKRLEIPMNVEAYIQSIVLKKTVERISFDRRRGLESGLNAKESWEAEMHEEPTPSLKEAKRDEDGFEIFLKNTPLISERGTTLEEPTININEESDLEEETGVVKEVEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUF9</accession>
    <name>A0A4Q9LUF9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1305p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001305">
        <property type="protein sequence ID" value="TBU11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUF9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUF9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1305p0010"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="296" mass="34470" checksum="C6442D9F7F003D61" modified="2019-07-31" version="1" fragment="single">MYLKEIILDGFKCYEKRTIIPDLNESFNAITGMNGAGKSNIIDGIIFVLGIDTNKLLRVSSIKEVINIHRKECKVTMIFNNYEKSLSPVGYVNYDVLNIMRCVDEEGKSKYFLNGHPCTNSTISKLFSSTGLGIMKGSSYPHFVVMQGHITKILSMKSNDLYNLIQETAGTRFYESEKEKSLVILQKKEKKLKEASESLFRRISPFFVQLKEERQAYLEQKNMEMKKKQNIEREILLQKEIESNEYSKVALEILENLKNYKFNKNELKEIENKLEEVRNLENDDNFLKIQKELEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL6</accession>
    <name>A0A4Q9LUL6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0926p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000926">
        <property type="protein sequence ID" value="TBU12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0926p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="530" mass="63782" checksum="00CA6D9C0E97FD02" modified="2019-07-31" version="1">MFSIFKFCCSIWCLNDLMPEREDYNMILPIYLEHNALTYVNTFRNYFPTLAKETIERNFGEIFNFDHSEAMVSNVDYIFPILHFCKLFLNISADIESFYCNFMLLLIRMKYIEYFDKLKNSHTNDKKYFQVSLNFAWNLQIIVNTLYDFLNTEEERIKVMFFLTNEKMKIFDKKTESFLDSSYFKFNFNFHDLVLKCRCNPFSVKWQEFFEGNREDIFFRILSLFFLSLYENTTSFIFDDNNFDRVKNCSVIIGDVFSTRKINEETDYCMAKVNIVFDASINKMGELMQKNSLLSGQESFNKIFMACAQECLPTSSTVTYTYDKAEIIWHIRNLIELYKIYNINSDDFEKIAKICNIIYILSYDFYSDTKYIQLWNFCLYKLSYLKEVLIETDFKHVDFDLSKKIVALCFEYHFSIQFQQFRSKLNKIRIFEYSDEFNQPILYVRSGYQPVFDSKLTLFFNHFSENIFFVKFLVPTDLYHYIFHNNLNLNVSIINLLHCSMSIQNETPFLSAFTKEYLKFKKIVNCYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUN3</accession>
    <name>A0A4Q9LUN3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_1266p0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001266">
        <property type="protein sequence ID" value="TBU11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUN3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUN3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1266p0020"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="26810" checksum="3C07CDC90B3B1A67" modified="2019-07-31" version="1">MEQQFILRVNEESKEILQTNTKNIELEVIGEDTVILRHNSIEYTGYISKLPCIIESHKTMDNQQFYKISDISHIVVIGNKIKGEHGITPPMYNAKHRFRKRVVKTQMVEEIENRVKELLERDKNCVGVELIFGEGEQKEESEDVSSLAAELEYNLIASEKNIVTEESDEIKQKKELLKELEEKIKTKEELLNTASNIILKKRFQESIFALKEEYNKVIGKIKELENNEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUS9</accession>
    <name>A0A4Q9LUS9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0764p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000764">
        <property type="protein sequence ID" value="TBU12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUS9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0764p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="460" mass="54371" checksum="895237E2CC38FFDF" modified="2019-07-31" version="1">MFHILYSQIFCITIGRKVIFRQIFNPHKTEEHINSTETLIYTVESNILKFNINEKHFERDSKVLLDFCDSKDIIIAIIFDIEKFALNFKKIEDSDASINSENSIKVLKVETFAIKKFELFLSTYYLHQKNISIKDYLNFIYFFEVIGVEFDDKYFKTVETLAASLLSVENLDSSDFEEKINNVFTIDLISRESSFFVFKTTFDFLFEDFKFKNFERFYGSNHLNLPNLIRERFITRYCNTLYLNEFSLPIYFDEGKYSKIQRNIIYLILYILNYKDIEIRFSFINNHSSLYFLLSLLISPIEDVIFNKCEINNSLINFLNKCAFFKKVKNIFILNAKICDGFEHKTNDLLNLESLTILEPQVSKITTMMCNDITEKLKIATENEIKERVFPEIETQAVDAGKCYKMDSEKYYRLIPSNKSSSTVLNIYLSSIYEHFIYKISGVILNDKLVDFFYLGINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV20</accession>
    <name>A0A4Q9LV20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M1 peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0897p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000897">
        <property type="protein sequence ID" value="TBU12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV20"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0897p0020"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="391" mass="46233" checksum="396149EA2F28BAB2" modified="2019-07-31" version="1">MVDENHLSLKQERFYLNNVNIKEKNQSHWFIPVRIGFQNEENILVEMKNKKEILVESDFKKYFKVNYGAYGFYRVLYKGDLLYKIQGMLEEKMLEPRDRLNIINDFFSLTMANYFQINDFLLFVRYFKDEENYEVLSSILGGLNELKSIFYKNEIKKEFFRNKILELVSRRAVKIDLAKPGTSLNEISLNALLISSSVGNEDSNILKKFVEIFPKFKKDRSLVSPVFRTSMFNSLMKMKPKEFYEEIFDIYTTSTVIDEKLMALSSLGSSSDLNYFLTFLSESMKNKVNLQDKIYVYFSCIANLKYRDSVIKFVMENFDGILQMFEGNTSMVSYVVERVFGILSEESELKELGNFFSKRDLKGYERSFMKVMERIEIRSTFRKNVENINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV54</accession>
    <name>A0A4Q9LV54_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0828p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000828">
        <property type="protein sequence ID" value="TBU12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV54"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0828p0020"/>
    <dbReference type="OrthoDB" id="2196297at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="329" mass="39329" checksum="629CE7B82C293F03" modified="2019-07-31" version="1">MNFPLDIKIDVFKSIEVDLEPQLETKKPKRRPNDDYDYEDPFIEQLENEYEAVELECNLSSFFIYSGKMPFDRQKVIKKYENEVKKAGTKDRKKRKDIIKEECTVKRCKIMEEIKEGTTELENKFLEIFLLQLIIENVDVNTFLQEMKELNKDINEKWIDKEYLKLKSKEIQCEFERYKNEITSLIGLKCHKHTDDLPVCKKDLFNSVFYDMVVIFIDLSFKLLYLESYLNETKRITEDVAKKRIYNDLYKIFPEGCDCYKSLGYNIFRYKQRKKSDKTTDTDTEMMTSIIGSLDKDSLTKDSEFFDTQIIENINTEETFETQDDEKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV58</accession>
    <name>A0A4Q9LV58_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0879p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000879">
        <property type="protein sequence ID" value="TBU12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV58"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0879p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="77820" checksum="C4D8E70F15862AE4" modified="2019-07-31" version="1" fragment="single">MGKRKKSLVAKKPKNNKIKVANDGDESKQAITRKIKLYEVNELYILAIPEGNKLMKLRTIFDSVTADPKEWPRIVFFAVQTRFERMPRNGWTELHRYYNEKFGCTETLEVLKKLAQSEMGKEVKSEEDGYDVQSPLVSLIHASKPTLLSTLNLRDKFSSKIKEISEKKIEKVVATRKEKPRSAWKENIESKISKLVLFKNLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEAIVKKNESLNVYEKKITMYESRKMFRKKSRMFERFRGRFHRGSSEHVVSRDEIVSFWSILTAGIYGIYNFFIEKLTTLHKYIYDIVKVIYIEGTPQPDWFYCGLTYLILKGIPRRGSDYRPITCMSNLYKLTTKCVTKVVQIEVERRGLLAEKQLGAVRGVQGAKEQALLNIALNKEYGNNLEATWIYVKKAYNSVDPAYTLKAMTRDINKEKSAPNDTFCEDTVILLKSVSLSTRSSFDAVQGKPILKIKYIKIFSLFNEHAISLINYHIGCLYLPRTELGRGLHSVKLRSEHMLLRNTTRRPAILKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLSHDYTRRHNEVVICLHLLLLNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV62</accession>
    <name>A0A4Q9LV62_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1164p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001164">
        <property type="protein sequence ID" value="TBU11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV62"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1164p0020"/>
    <dbReference type="OrthoDB" id="2194262at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="220" mass="25944" checksum="1E2D9146DEBABB25" modified="2019-07-31" version="1">MRSDLQKILLKYIKMEINKDEMKKYLEENKISVKEFNKYVAKFIKKLHSVSNSYKNLHLSQECKISKKISTDEFLDENFISEIENQLDQYKTTDENDNLVESENISEDMSFPDILSIDQKDLKYYTVDYNILSSKINRLLSFEDLQNRLARIAKEANLNPKVDKETIESVNNAMNFYIKHLIMKALKTAKNKNITIEDLKNAIKNEEPNHEYPDIKDDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV66</accession>
    <name>A0A4Q9LV66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0704p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000704">
        <property type="protein sequence ID" value="TBU12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0704p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020335403" evidence="1">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="180" mass="21647" checksum="CE790E426CAE7518" modified="2019-07-31" version="1">MYIFLLFINSFILSSDDINNKNQNYAFLDLKNGHLPEIKDNTFSTQMRARKYLQMRSDRYRNTSVSTDTNSEENNTVFSNDFYKRLLEDFMVLMIEKRKEIKNYITNLMEKCLIHEKYANRLYLIGQNIKDKIDLVFLFCNDFDMNSDKIEYEICRQLISKCKEDISLFQKSIEMLLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC9</accession>
    <name>A0A4Q9LVC9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0681p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000681">
        <property type="protein sequence ID" value="TBU12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0681p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="207" mass="25041" checksum="0BF4DFA02234F2B3" modified="2019-07-31" version="1">MAFNISDFLEILENSNNLQKIYKKIFVYKKYFITLFSRINYSNEYLYELVFVNYLTEILTIFYVIISLLSKNRISNIESIFDLDLKQLILCTFKNENFFIFLNNIYAIYKIRIVKFDFLNCYKIFLFGILLNNIFILLLKNITGRLNHYGSVSFIVFAKCFDLEWNTFVDLVGYLAIDFIYRSECFPFEECFSAVCLYKLYKWFFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVE5</accession>
    <name>A0A4Q9LVE5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1114p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001114">
        <property type="protein sequence ID" value="TBU11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVE5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1114p0010"/>
    <dbReference type="OrthoDB" id="2192730at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="234" mass="26874" checksum="FD318726BDC85D08" modified="2019-07-31" version="1" fragment="single">MDNLPRKRRADFQLSPYAENTNIKQTDTSINKPTDTNQEIQRKRARARPLNEHKDIPTLKGIFKNINIPSEINMMESVKGSVNENIEEGMKENGKENRIAGLNKSFVRALEYVINVESSKNLIFLFEQYKKFLKEIENEIFTNPKEKPFSELKDEKKSFFSTNNVTDSVQKKDNINPFSNLLPPSVDRKDSKDSVKDNINPFSNLLPPSVDRKDSKDSVKDNINPFSNLLPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVK0</accession>
    <name>A0A4Q9LVK0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1088p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001088">
        <property type="protein sequence ID" value="TBU11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVK0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1088p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="294" mass="35350" checksum="4E0B28EAE6BA49EB" modified="2019-07-31" version="1">MDYSTSSFASLFQENIFTGKIKIFEFLDLKYKLWEISCQIGCFIEFFDISIIFEELDLNEFKVKGTFFERNIRKIIINDSKINFSFLEDILDLYKLKRLKIFESEISLEKTMNINNNTIECFIYRAKCDESCRYFYELVNLMTNLKRINFLMDRRINLRWPDAVKINIRHFEFLDVFLYKEYIDISEMKLLSNFEPKELLHLSAKCETGSLKCLFSRNNFSQVKKLNLSRFVIGNEDVKVFKNNLNSENIKFFYINLRLISISDLFCNAKDYNIKYIYLSNIYVSNQIWNLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVR5</accession>
    <name>A0A4Q9LVR5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1052p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001052">
        <property type="protein sequence ID" value="TBU11755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVR5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1052p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="42396" checksum="0C8508F6AAA0E236" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLSNRYKFKSSKRIRSHSVQQFLIMIITDVKIRNNRPNIFILDKKKNKITLIEVGITSQDSLQIVETEKLKKYDLLANELGLIYRCSVEIIPYVMAWDGIVTKYYKSHLKSLEIPMNVEAYIQSLVLKNRAETISFNRRRRHESGSNSEESWERASMGIIMRSEVHEEPTPSLKEEKREEDDAKNFKSKNKAPFISQGGTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVX0</accession>
    <name>A0A4Q9LVX0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0965p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000965">
        <property type="protein sequence ID" value="TBU11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVX0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0965p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63266" checksum="84B58454C6117E62" modified="2019-07-31" version="1" fragment="single">MENLNLPDWILKFFKVIISKWKIDISVGPEKIMIKKIDRGILQGDSFRKLNEKYTKVTVQTDAESLLTVHLLFIDDLKLLAKAAKEFLKVIGLEINQEKSATNDTCCEDTATLLEGVNSRGIPTRSSFEEVQSKVISRVERLCPTRLNAKNLFSEINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLVKNKIHLRPGCKERLYLPRTELGRGLNSVELRSEHMLLQLLDCLEKSKEISTRRAAILMVENNNKTHLTLIKGFLKVKYRLVEEVTYKSLEEAQLTKLHNEIEKRKLHLKLYNARKNDPLSVSDSSIWLNKGNIRPHNEADRNVFWGAECMCQHWNKSGHDYTRRHNQVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKTRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANGLGLIYKCSVEIIPYVMTWDGIVIKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ3</accession>
    <name>A0A4Q9LVZ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0628p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000628">
        <property type="protein sequence ID" value="TBU12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0628p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="426" mass="50772" checksum="CA5894E591464DE6" modified="2019-07-31" version="1">MTLIFCMFLQSSFESFDFVEHRDHFVQKCFELYKKETNNLDKLPKAVDYAILIFSTKFNSNAAISITSYVKKSIGKTFEVVLYISCISKYGSNKKVAFEILCLKKLKNKFIHISLSYPSRIFDLNYADSEKETRFLLQNIKFFDQFLVHFFRMYKAFSRFARTRQNTRDSYIRIGDVTNGKRTKVPKKFQIFKRNPRYDLIRDGICVRLHSEIEFLEAHSFDEDIILNNFKSLFGETKFIYFRGYSVYSLENIVLVKHENNITDKYYSSYLKTNSICYINESNASVQVIDFDIPAIPIHFLKTFNIEFTYYNEDEDTERKSKRFRIVFKHSNGGFEFNNNLPVECIMKKYKPTNPIYICVLWKNIFDIVEFECESVDSSKCKFLRIRMYNVSAEIPLVKTSFYHVQGMSCIKYLLEIWFFNNEIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW60</accession>
    <name>A0A4Q9LW60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutathione reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0595p0040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000595">
        <property type="protein sequence ID" value="TBU12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW60"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LW60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0595p0040"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="11">
        <location>
            <begin position="335"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="443" mass="50485" checksum="C23F6792A775EFFD" modified="2019-07-31" version="1">MYDLIVIGAGSGGLSAAIKSKKMGKKVLLIEKARIGGTCVNVGCVPKKITYNLSNLLFTLKFSQFYGISISEYKIDFEKFVKKRNKYIERLNNIYKEKIKDIEYVEGHAIVENDQVIVNEKCYTYKNLLLATGSKSIVPEIPGKEYLFNSDDFFELKERPDKVVIIGSGYIGIEMSFMFVSLGSEVSIICRKNAVLSKFDKMISENVILYMKEAGIRIFFDTEIERIEKIDKKYKLTFKNKEENFVLNDIDFPLCAIGRDSDLSFIKSKIEKNGNFLKVNENFKTSIKNVYAIGDIINNYMLTPVAIFCGRSLVDHIFESKYKNIEQELRIFECVPSVVFSHPPVATVGLSEEEARRKYSEKVKIYKSRFVNLYFSMSDTKEYSEYKIVVVEDKVIGIHICGLGSDEIIQGFAVAIKNGLNYNDLKNCIGVHPTASEELLFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWQ9</accession>
    <name>A0A4Q9LWQ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0505p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000505">
        <property type="protein sequence ID" value="TBU13199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWQ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0505p0030"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="358"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121918" checksum="6CA2FA28DFBC589E" modified="2019-07-31" version="1">MTNPCTLAIQEGNRLMTLQTIFDSVIADPKEWPHIVFLGSRDKLAELHGYYNEKFGCTETLEVLKKLAQSEMGKEVKSEENGERRRIATCLADTCTLTDTTEYINLRDKFLSKIKQILEKEIGKVVVRTRKHPNELVDSITVTAYIMQAAQVCYDEATCKEKPRSAWKEKIERKISKLVLSQDLLEKARKQEKLSTSETKSLKKIMREFNLNLSSVTDLSEALVKKNESLNVYEKKITMHESRKQFRKDNRMFELFRGRFYRGLTERVESEHVVSRDEIVSFWSTMWSKNDDTVTYDDYLIPFVSDNHPTTFPSLDEFVNIINWLPNWKAAGIDGMYNFFIKKLTTLHKYLYDIVKVICLEGTPKADWFYCGLTYLIPKGIPQRGSDYRPITCMFNLYKLTTKCVTKIVQIEVKRRGLLAENQLGAVRGVQGAKEQALLNIALNKEYGNNLKATWINVIISKWKIDISVGPEKIMSKKIERGILEGECLSSLLFVLCMDPLSRKLNEKYTKVTVQTDAESHSTNHLLFINDLKLLAKDSSTLSAMTDEAKEFLEMIGLEINKEKSATNNTCCEDTATLLEGVSVYKYLGIIEDSRGIPTRSSFEEIQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLKPADFSKLDDAVLAVIVKNKIHLPYDIKSLRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKIHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKKGNIRPCNEAGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSYADIREDSRIITDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYMMTWDSIVTKYHKSNLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESCERASMGVIMRAERHEEPKPPLKEEKREEDGAKNFKPKNKALFISQGGTTLEEPTNNINEGSEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXD6</accession>
    <name>A0A4Q9LXD6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CWI38_0552p0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000552">
        <property type="protein sequence ID" value="TBU13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1176355.A0A4Q9LXD6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0552p0020"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="18"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="164"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="13">
        <location>
            <begin position="1401"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="14">
        <location>
            <begin position="1698"/>
            <end position="1951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="1951" mass="225834" checksum="FCB424EAA37C670E" modified="2019-07-31" version="1">MKKKCFTTFLEEYGCSKSIRKLLIANRGLAATKFISSMEEFSYKKFGKQIFYFYGMVIKEDLESNYLYIEKLKNYKLVESGPAHLNYCNIPLIVETAKYFEVDGVWPGWGYSSENPELAKLLQENKLVFLGPSEISMYLLGDKFISLLLCMNLNIPVIPSLVSEKVIEEFGIVFNDTNVIDRERINKLMSDMPGSYINEIDPFVKTYGLPIVFKVSSLGGGKGIGVVRETNELNLVYEKIKKEANNTFIFASKLIENVKHIEIQAAGDCYGNIKIFGSRDCTLQRRNQKLVEECPAMISRGIYKKMKNDAKKLLKKANYVGLATVEFLYDIEKSTYYFLEVNSRIQVEHPVTEILYQINLPVTQWMIASGIKLKRIIKLFNVKKRKIHALAVRITAEDPKKNLEPVTGKISLHFQNNQNNWGYFSVVSGKIHEFSDSQFGHIFSKGKTRTEAVRNMIFALKSLKVENILTPKDFLISVLDSELFLNYRHNTEFINYFLQKNYLNVLGEEDLNFIYFPVVYCLDILKILDSDKNVRNNLIFDFIEKHQKSINVEYLYNTIVYNIELFFISTNSALIKLNNTFKIISYEILSKNLILLKTGKTKLIYLEKEDNLLYNMKIDGCIHKFVLDFNSNNVRSKTAGKIVRFLKNDGQAILKDEKYVEIEIMKMNIFLEAPCSGIIKFTKPCNSYVKENEIIATIQKENKENYVYSTYKFLENVGNELDLKNILFGYYFPPKLKDLPNDVTEKLRYIFLFNKNFKKISFDLIEYILASLISDIEFSFESLNLNEKNNHLSNIGTKDLLISVDEIIMKLNSKNSTLFNLFSKFKRTITHIKFLNLCLLTKMHNDSDNRLNNCCFPKDVLLFSINIVEDNVKDIIIKKYLGIVFGEAIKFSKLNRKSLNINKIDIQKEKKLSEEKASHQDLLIKNQNIEFKSKRHFGIFILEDDISGIEFAQYDYIFLYNIEKTDFLTNINNKNVIKILTDKKYPFVTYDFKPNDMKVHLNQKNISNTNVGKNTAKDFPMQNSQKLHSKYGLKSNNNNKISSQIQNSSEKTHFGDIDINENNEFHDFYKNLAYTSILSKYENSLIDPLLFKYLEIERFRGYESVLIHKCLFRNMFVFLSKANNKRRLFVRFIIDAYSGNTISDMNNLIHAIFQILSTIKILTFQHKTTNNHLLVVVKGNFSFSPASTYDIIDDCIFFFKDKFLEVNVTECEIKIKLLDKSRNDKITLDNAEEDAKRKRVDFFVILLSHLKGYLEKKIYKNDQLVLYQINSHLIHNTLKNSLITNKNNGNIFFREQKYDNCFHSLEDIQDKREIAIKNSTVYYKDLIELFECNFVSCNFSYEIQQLFLHSKNFDAFGINLEKNQESKDLERKNNSYKLNNDVYFIDNSEKESICNGIVGYKISFNGNAFILIANDISFKNGSFSIIEDVFFYLLTLDAMDSCIPRIYISCTSGARIGVYEKIKEEIEICIDPQTTKDTTENMCLIVRENTDDKMTLEAMENKYKITSIFGNVDSGAENLSFSSLMANITTKAYENIFTLSYVTGLSVGIGAYLVKLGNRIIQKNKSPIILTGNRALNKLLKKEFYTNNNDIGGSDIMQANGVSHLVVIDDYQGIEQIVKWLNYYFNSRIMKEKKDDLINSTLLGEKISNILCDEKNDFCKNGVDAKNHSYRNLEYTSSHPFIENKLCTISYQKTGFDKYCSSNYFMENYNEREVLDFILDQDSFTEYMTNYAPNVIIGRGMIMGKTIGVISSETKNIENEIPGEPDTIRKKKIWTKNVMFPETAKKISDSIMNFGKECLDILLLANWKGFSGGTTDMLNYVLDFGSNIIRILSKLKSKILVYLPPNAELRGGTWVIFDKKLNANIRICAHPKTEVGILEPDGLSAIKFKEEERIKVLERSGMEINVENLNKLGHLFCKLHDSTERLIQNNIIDEFVSVDMLRKYLIENVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXU6</accession>
    <name>A0A4Q9LXU6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI37_0025p0030</name>
        <name evidence="4" type="ORF">CWI38_0717p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FI-OER-3-3</strain>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000025">
        <property type="protein sequence ID" value="TBU05307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000717">
        <property type="protein sequence ID" value="TBU12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXU6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0025p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0717p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU05307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="142" mass="16023" checksum="7B04CA02774A5A4C" modified="2019-07-31" version="1">MVKVRKAVENIFFSIKFLCLIFFLLGILCSEKNEEVDSSKDSGNLCKKCFHPHEPNLRCFTAIKNLEMNIKSHASTIGVSERHDDTKKDDMIDETSSASSNEEIFDDKDRHLSDYDLIDISEGSITSDIDEIGTKEGEGIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY45</accession>
    <name>A0A4Q9LY45_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0344p0040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000344">
        <property type="protein sequence ID" value="TBU13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY45"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LY45"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0344p0040"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="469" mass="54296" checksum="A5ADF320B9F00070" modified="2019-07-31" version="1">MVQSNLHTWLKAAAENKITTKNTWKSNIIEYLADVNQFIENNGLNFQMASSTLDGAVKEFSTRVDDVSENTNKLLEHLDDEIDSDGKDNTKNRQRSKRQNFIEKDVENLNIKLSEQINQTKLFKISCRKTAHRLLLDYIFISSHGIQNLSLDENIFHENVILETKEYPLNLEECDFPICPSIKDIQNHSVKRISTHYTGLENREDLIENKAENVNFENDFQNDFSTEFNNDFNESISETNNPPLITSSNSLNAWAGPEHWKSSISKKTKARKPTQKNLLNFSIKISTNILEKANTIFDASYISRRREDKPLLPNDYKINTEDIYKYAVREGSFYTNNNLEINDTSICGNITTNTEITAVSFIKEDLKEEIVVDIPPTERKDIIENLISKYNRTQKKVDIKKLKYKVYFNVEKNKIARLSDIYSEIKDSYDEIEKKDISVHYCIISLLHLASENCIDIQSGDNDILVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ5</accession>
    <name>A0A4Q9LYZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0251p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000251">
        <property type="protein sequence ID" value="TBU18152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0251p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020473138" evidence="1">
        <location>
            <begin position="18"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="578" mass="69314" checksum="3C6265278A00A0D8" modified="2019-07-31" version="1">MLLGFILLLLFGLSSNASFIESEDENIDVETIENTDISEWKPMCIPNTENTMERFDGSFASKKSIKDIHSRRLKNDMPLREKIKFRLDEVLKDFELHYEYLTISNIERYTYILSKYEYQVYCSFEVLKKNLYENKKTTAFSFKYMHEEILTDFVDVENLYLNIKKCSILINKIYRFFLLENEQFGSLESIYMEQDNQNPDFILTLFTDLEFANIICQMNKEVEKLNSGENFEHDYKKLKLEYRDCEAKICVYSVNPVSPLFCLPDWDRLYSSNFITNWKKTILEILDKKNNYIFFILPEFISFEFRLKEELDSIRLKNGDYFKAILNLKLLLNNPIVDKIQQRYNNQESKNEDKFNHHEERRWYLKKKQHLKKCFMKVIKIFVLSIEHNLIYSLMYTLEKTIYYGFVGNRLGDNSLFYYHKLNILNDVIFLMNENLIKSIFLNLDAMMICILHKLPSVAKKKRYTDNFFQNFDETVKRSILHLYIRLSEYIIKIGTIKKICGGKYEFIVFQFEAIKIFLEGSEETCILNSKKSGYEKEFKIDELLQFSACCLQQILGLSFHRTCFHNLRNWFKGFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ23</accession>
    <name>A0A4Q9LZ23_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5050 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0563p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000563">
        <property type="protein sequence ID" value="TBU12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ23"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0563p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="36858" checksum="064098F6FA49CFB7" modified="2019-07-31" version="1">MNTRFLTKTNHKNITSDTFHKFIALYTIGEKCVDIFSLKEEKIIFKHNFSKEIYNITFSYTGEYIIITHKKMINVFNIYLKKTEFYILKENITECFLLRNKKIFSGENSKFCIFNHLNQEELEMNCDKYYVYDNRYIVFYYNRSVTIMNEDCKILYEKKMDFFVDKNIYYNIFNGKIYFLIQSCIKGTDLNLNLENICENNFPDTFFLTKDVLYLCYMKLNKIIVVNKNLSKVLLEKNICNYFFNYFTGNMIVLDKYGLEIIEYSNNYLKQFEFIYENQIYMEEEDEFDKSDEERICGLNLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ25</accession>
    <name>A0A4Q9LZ25_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0246p0010</name>
        <name evidence="2" type="ORF">CWI38_0248p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000248">
        <property type="protein sequence ID" value="TBU18230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000246">
        <property type="protein sequence ID" value="TBU18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ25"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0246p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0248p0010"/>
    <dbReference type="OrthoDB" id="8042260at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="249" mass="28611" checksum="E8B3CF5473220CFF" modified="2019-07-31" version="1" fragment="single">MSKKIQRGILQGDSLSPLFFVLCMDPLSRKLNEKYTKVTLQTDAESYFTKHLLFIDDLKLLEKDSQKLEDMSEKVKKFVNNLEFKINKEKSPTNDLSCGESATLIRGVRISTRSSFEEVQSKLLSRVERLCHTRYNAKILFSAINQHAISLINYHIGLLRLESAGFSKLDDAVRAVLRLYFPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTKQAAILKVENNNNPHLAQIKGFLKVKYRLVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ44</accession>
    <name>A0A4Q9LZ44_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0090p0030</name>
        <name evidence="6" type="ORF">CWI38_0244p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000090">
        <property type="protein sequence ID" value="TBU04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000244">
        <property type="protein sequence ID" value="TBU18373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ44"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0090p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0244p0020"/>
    <dbReference type="OrthoDB" id="1922626at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU18373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="33463" checksum="D9ED261A9E47BB23" modified="2019-07-31" version="1">MKNKESHKFNEKKRRSRQKNCINVLRFLIPNLSHRRSSTLTVLEEAIKYIKYLEFYSGINNSDLKFPRKVDLDEYKSYETNEESKKKDLMKITTNILQEQPYLFRNKKILLSQSKFLQEKNYKQVDFVSENKIKIQSFEKKDDLMRKFDYPKNIASPTNFMLPESTFCNFETENRFKIYKTDKNESMNFKNIKYYSSESKQGEEKETIYHTNWKEAQNKNDENNLLTLNSTKKIPICLICDDLITEVCFICSSCNKNFHNRCIKNLKSFKNEKCIFCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD2</accession>
    <name>A0A4Q9LZD2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0512p0050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="PITK01000512">
        <property type="protein sequence ID" value="TBU13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZD2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0512p0050"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="214" mass="24577" checksum="4BD038DF2002E410" modified="2019-07-31" version="1">METKTDENIKRIIDIIYEKYITKQKYIGIGTGRTIEILINHLKNKNIENILFIPTSLSTMHILNLNKFKISQINLYNTVDLYIDGADYYNKDIGLIKGKGGALTMEKLLAKMSPVFVAVIQKEKIKETFDDLYVPIEILPEAFSYIVSILEKEKIIYSLRQGTGKYGPTITENGNIIFDVKYNLEFLKQCKKITGIVEHGLFLKTEFNIKIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZK3</accession>
    <name>A0A4Q9LZK3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0346p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000346">
        <property type="protein sequence ID" value="TBU13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZK3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZK3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0346p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="124" mass="14213" checksum="1414C0B6597F0853" modified="2019-07-31" version="1">MELEIVLGIVIRDSSRDSIRDSIRDSIRDSSIRNSIRDSIRDSIRDSSIRNSSRDSIRDSIRDSIRDSSIRSRIVVDIVVESSIRDSIRDSIRDSSGYSNSSRDSNRDSSRDSSRYSIRDIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZP7</accession>
    <name>A0A4Q9LZP7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0438p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000438">
        <property type="protein sequence ID" value="TBU13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZP7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0438p0020"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="125" mass="14721" checksum="854E2303C3300EC2" modified="2019-07-31" version="1">MNRVVKGVIYVRVVIYDMSSKGDEVRNEHMLLKLLDCLEKAVILKVENTNKPHFALIKIFVKPLKMIHTSQLTKLYNEIKKRKFYSKLYNARKNELVSVKNIKPLDEAIFCYIGNKNVFWKADDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZR2</accession>
    <name>A0A4Q9LZR2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0381p0030</name>
        <name evidence="2" type="ORF">CWI38_0474p0030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000474">
        <property type="protein sequence ID" value="TBU13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000381">
        <property type="protein sequence ID" value="TBU13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZR2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZR2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0381p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0474p0030"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="203" mass="23478" checksum="826F655E9F7EA008" modified="2019-07-31" version="1">MPSTIYISDFVYEMESILRKFDNKDLKLMISGGSILTILKNINFKNIKTTKWKIYFADERISQQESDLNFFDAEFLKSTDALIYPINTKICPEKAIEDYISILEPINVCFLGVGEDGHIASIFPNSKNITKKEMFIYVNDSPKPPKERISVSISYLNTVNSIYFFIPPKNEILKDVCCPDQSIQKELKDDYVIFLDSRIKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M041</accession>
    <name>A0A4Q9M041_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0393p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000393">
        <property type="protein sequence ID" value="TBU13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M041"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0393p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="649" mass="75443" checksum="BE65585C10DDBFBC" modified="2019-07-31" version="1" fragment="single">QNLTYENFYRFLKILDVLDPISSEYLNQFYSHLYRECLLEKVSVRIFEDSAHYRENLFDEKHRIRPFMYFFCTLINSIDACFIPKSSTLSLFEKKKQHIDECFRDSIDIANLILKISSSSLELLLRSLKTNEWAAFNWLLAVTKVSGFYIDNTELTFNELKVSSVCSLVCSESFEKCIVSLKKISDDFFLNLTGSNIRMIKYLKFVNVDISFDLLDLVILRGVVSYLEISYCVVDESQRITELLPKMYEPNTFKVAGLKMNTKDIERILYSKIKVLVLKDCTLDVDSIWKPRRDQRGDFRLTENLEFLDISLSKFPVCFVQLLLNSTKLENILLNSFEFTGCESFDQILSVKRNWKNFEHDQYIPNEYLRALFTSDVSVGSLCLRRVIDFDSVAFFFEIPNFIKSVKSLDFSDCKLTVSSLNFIGNFYNLKSLNLLKSLPSNVAGLMESKIYENLTHLDVSYNDIFLSNYLYITMFKNLKALSLFGVKMRGSLLGLILTDKMIYSLTYLNIISSSLTLLNFKRISECFRLSTLLFSLEGSCFMGKYCDICKSTLLGERLSILHVSTSSDISIDDVVALAEFHDLSEVKISCRTIFNRREKDIIKYDSIYSDFRIQFVLKQFIKDVQVVEILREMFCNYSISIIYEETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M067</accession>
    <name>A0A4Q9M067_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0160p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000160">
        <property type="protein sequence ID" value="TBU19979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M067"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0160p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="22858" checksum="33F8BAD7A1DEA955" modified="2019-07-31" version="1">MKEEQIQHIEVNVIIKEIFTDTISISSSDGCYIEQNPNHIFFRSVTIGNLLTKNVDAIYSIETDPEAINVLPETEQLLYEEIDNELKSTTKANRYPKLIFVKKYAMFLYFSVLDFIDTIIIGSYLYKKPAYLFILSCSFYLGILFVSLGVFSQKKIPTIFKYLTAFIYFILISAIISMYLCVTFTNRNPITEGINTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M088</accession>
    <name>A0A4Q9M088_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0160p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000160">
        <property type="protein sequence ID" value="TBU19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M088"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0160p0010"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="514"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="682" mass="76865" checksum="323B509009E0A4AB" modified="2019-07-31" version="1">MGRKANVSSEVSKNTKIKAANDADELHPPAISLPSSSYTTITPPPPSQTCSKMQNSGLDPLPSPNAPVTSSVEVSACEPSYDMTSPCTQTIPEGNRLMALRTIFDSPLIVFFAVQKRFERMPRNGWTELHKYYNEKFGCTETLEVLKKLAQSELGKEVKSEENGKRRRIATCLADTCTLTDTTEFINLRDKFLSKIKEISENEIGKVVVRTRKHPNELIDSKVLDLIYRVVGEYAGANVPESITEAAYIIQAAQVCYDEATRKEKSRSAWKENIESKISKLVLSKDLLEKAQFNLNLSSVTDISEALVKKNESLNVYEKKITMHESSKQFRKRNVCLSFSEVDFIHVVSRDEILSFWSTMWNKNDDTVTYDDYLIPFVSDNPPTTFPSLEEFVNIINWLPNFEAAGIDGIYNFFIKKLTTLHKYIYDIVKVICLEGTTQADWFYCGLTYLIPKGIPQRGSDYRPITCMSNLYKLERRGFLAENQLGQLEQALLNIALNKEYGNNLNATWIDKIDRGILQGDSLSPLLFVLCMDPLSQKLNEKYTKVTVQTDAESHSTNHLLFIDDLKLLAKDSSTLSAMTGEAKEFLEVIGLEINKEKSATNDTCCEDTATLLKGISVYKYLGIIEDSRGIPTPSSFEEVQSKLISRVERLCHTGLNAKNLFSAINQHAISLINYHIGVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M089</accession>
    <name>A0A4Q9M089_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0145p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000145">
        <property type="protein sequence ID" value="TBU20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M089"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0145p0030"/>
    <dbReference type="OrthoDB" id="2400393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="105"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="431" mass="49829" checksum="3C27D5BEABD27974" modified="2019-07-31" version="1">MSKKDSCCEIVNEINSSDDEFFMDSFDDKEECDKNSFTNFVGDNENEENDNDFSSDSDIIVNKRTKPETIGSILFLCLRNEGPQSQQIGMHEIKLPKKDSQKDLHYLDFLDERFKEHFVPSREISVDESVVGFKGKISFLTYNPNKPTKWEIRMYIMANANTGYVYSIFPYYGSLTSEDLIRPDLPVSTRIVLELCNKLLDSNPGSTGYHIFTDRYYTSLPLAQELLNLNIHFTGTIHSNRKFLPNSIKKPRFSENNTFACRSGNILLSAWKDKRIVLALSSWDVSGTEPVNLRVRGGIIQVIHKPHIIVNYNKYMGGVDRIGSYAKSYCFLRKSLKWWRKLFFWGLEASSVNAYLLYKIVKTRQNKRPINHLKFIREIVDGLTQNYREGYKTHGRPSITDKEELLNGKLHIMRMKPVTFAAHALANQEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0I3</accession>
    <name>A0A4Q9M0I3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0225p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000225">
        <property type="protein sequence ID" value="TBU18877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0I3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0225p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU18877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="6981" checksum="C93B11ED1A0CDAF1" modified="2019-07-31" version="1">MDALEGEKLCKKLEEVNKNIISELDIRNNKLKKAINCNTQLEKKLKMYEKLFLEISKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0K9</accession>
    <name>A0A4Q9M0K9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0214p0080</name>
        <name evidence="3" type="ORF">CWI38_0220p0060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000220">
        <property type="protein sequence ID" value="TBU19113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000214">
        <property type="protein sequence ID" value="TBU19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0K9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0214p0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0220p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033445372" evidence="2">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU19113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="122" mass="14640" checksum="792C594E4BB769A6" modified="2019-07-31" version="1">MKLFIFLVFRCKKLVDTVFEMEEYVNECVKDSLLISDTCNNLKTIYNCFQEFTIEITNLLKEENEKISEELEKHENEMEDIKNKYEKVKNSYFNISKGIEKLFSEEENIEGNRNELGMNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M102</accession>
    <name>A0A4Q9M102_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0086p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000086">
        <property type="protein sequence ID" value="TBU20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M102"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0086p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="27559" checksum="EC6DE5C47DA76866" modified="2019-07-31" version="1" fragment="single">MGIRKYVGSEKQKEKIIKAANRASEVDGVIRECKNDQGIPQPSSYTPSTFINNISIPPSEANTNTKRQEFIRCVLFAVQTRFDRMPRNGWKEIQSYYNEKFSCTETFDEENGERRRIATCLAEPLVVRTRKLPNELVDSTVLDLINRIVGEYADSHVPMTITDIAQVCYDDETQLSSSQTKSLKKIMREFNLDLNKTNDLSEALVKKNELITVYEKKLTMYESRKQFRKENRMFELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1E6</accession>
    <name>A0A4Q9M1E6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0308p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000308">
        <property type="protein sequence ID" value="TBU15713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1E6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0308p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU15713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="751" mass="87119" checksum="384A0B349349F3CE" modified="2019-07-31" version="1">MIMSRKTYSFRYYSFVLLKIVIASYREPDFDQNQTAESGLPANLIANNNFYIHPNNGLIYQNILGQIMPVYPYHSDLWPTLVHGMPPYYTTYDQFLYPPSVQTLYGQNHVLQPFNSFTHSTFTAGNLFIGSNTNPLYTNQPLQSIALASQGQVESFTHSTTEVTLPQVNNEDSQMICSLSEQQDSYSQINITNDSESEYISVDNNSDDIDVLNLSPPILSVLEDQNVPCRAESLDVSSNPDQNITEVSSPKEYLEVENTASSFSHCTDKYIAVADNSELLYSLDLNSRLRIKKEKYKRELSMRRFKPTKIESLEKLNSMQRKYEDLLKFLKESDLNDEGNLREIFSPNMANSSTSLLESESSGNIKNVIVLNKFAIESMKSIILNIFSKNGTSNTQNELNFYDLNFSTNDFKALVEKAIFQVEIDSSDDISFIFNTCLSFVNYEEKLFGNKNMTEIVETLKLPKIENLFKKLKECMQINTVYEIMFFMDLYEKNKVEVIQHYVVSTVFLLNALCVYLPKTNYDDFFCDPNYAYYDNSKERISTAAFNVGLLFEKLLRNLKNHEIKADSYGLLNFLRYFFKTNSLNYYRRSMFSIQIPALIAIVLDDLFSFDECQLKEFASFVIYIIKCRKNNEIDFYNDKFEYFIQNNIDSFSTVTECIKSFIKDYGEISDKGPEIQELRKRIKKILEEVPDSDAGMSSKKNTPLRNIYLWQLIWNIALKKKSYAFYTNHSNIFVMVKNTLKKFESYYIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K4</accession>
    <name>A0A4Q9M1K4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0281p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000281">
        <property type="protein sequence ID" value="TBU17621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0281p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU17621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="353" mass="41181" checksum="49B9EFD3366D3710" modified="2019-07-31" version="1">MPNIESDETFSMQAVGNNPCLDSDQRTISECSHFQPAYYRSKNTENFLSFSQRTSNKERDKMSRDSINLSKMGNNAKEQLVEEEPYLDSEKFVIPEFSSLTSDVVKEELLVLELYSTPKDNTVAYIQNGTEIDVDRTKSNLKRGNDANSYDIRWQRNDSFISDDFSEHSNKRPRVNKKARSSDIGNRDASISSDSHNNPCLYLPECEPICCENNHEDTKIASYINQFKIRIYADEMIVCARKCSTYFYYLNLVPELYLELNNLFKIKKPNEFPSNNQNYETDLRYNNYLIKIKNEIKKYDSVDIGTNEMIEEIVIFANYLVEFEKTISSDFILKEVLKISYDITDIVKEIIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1K7</accession>
    <name>A0A4Q9M1K7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0046p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000046">
        <property type="protein sequence ID" value="TBU20600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1K7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0046p0030"/>
    <dbReference type="OrthoDB" id="2400393at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="122"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="612" mass="71312" checksum="2CE64E62F5FBFBEB" modified="2019-07-31" version="1">MSKKDSRGVIMNEIDSSDDEFFMDSFGDKEECDKNSFTNFVDDNENEENDNDFSSDSDIIVNKRSRTLPLPSTSSSEEDVSETRDNRPWKDVTIEDNPPKRFDFISGVRNEGPQISVDCTKPLDFFKLFFTDELIEKIVTETNRYARNKITQKRLSKRSTWHSWVDVTVEEFRAFLGVVLNAGTITLANIQEYWTKNFNAKKPFFGNILRRERFLQIFWMLHLNKNNPNDKSLRARTQKVRDYLDFLDERFKENFVPSREISVDESVVGFKGKISFLTYNPNKPTKWGIRMYVMADAYTGYVYSILPYYGSLTSEDLIRLDLPVSTRIVLELCNKLLDSNPGSTGYHIFTDRYYTSLPLAQELLKLNFNFTGTIQSNRKFLPDSIKKPRFSENNTFACRSGNILLSAWKDKRIVLALSSWDVSGTEPVNRVDRADSYATSYCFLRKSLKWWRKLFFWGLEASSVNAYLLYKIFQTRQNKRPINHLKFVREIVDGLTQNYREGSKTHGRPSTTDKEERLNGKLHIMRQNEGKKDSLYIEVIMRSEMHEEPKLPLKEAKREEDGAKNYKPKNKAPLISQGGTTLEEPTNNINEQSDLEEETAVVKEVEENIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M215</accession>
    <name>A0A4Q9M215_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0031p0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000031">
        <property type="protein sequence ID" value="TBU20715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M215"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0031p0110"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="398" mass="47371" checksum="E79271D34BFF4402" modified="2019-07-31" version="1">MEENKDNDQNLSVIEQNQDYSITDVSYALSSFSKKIGQEILEYHRYKGIYRPLLDFENENIFSEISLIRNIPISSNNTLYNRYYTKVSNTLKYYNSIRNLPLYFILKNSKKVVFTFEWIISYEELERFKILKKIENLRKNKNLNLEYFYEKVENKKEIIFKENESKRFKISKNGYFKDKKMCKNNGISDGMENFKDEKIFVNNGISYGVENFNDKKMCKNSGISYEKQKFNSKFLFLIEEKSKFIKQVWQEQKRSTKCISDSILLFFLGNRNLHKKFINRSHSNSFIQSFFVQKTCEEVCVKKEDKPQNVFKKMVSMFEILKHARSKSSFSYPVPKKLPVVHLSHTVAISQIDPSLEKLRSPTEIYEFLKNRKKQETKSPGYINKSPNGCLDYGYKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2J0</accession>
    <name>A0A4Q9M2J0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0110p0020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000110">
        <property type="protein sequence ID" value="TBU20218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2J0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2J0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0110p0020"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="163" mass="19613" checksum="B80120510269597A" modified="2019-07-31" version="1">MRFFDNYMLYDDDLSLEERLEIYKKNEEDFEAKKVYMNSVQYDLESFLLDFEKRVYFGDVPDSPEIKRYSNTVVVEKPDQRIFRSVFFKNSKPENEKYGDVRIYKCYLYDCDKEYTSSYGLKYHLINGHSKKIAEKPYRCTVSGCSKKYKNSNGLKYHLNHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2S8</accession>
    <name>A0A4Q9M2S8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0003p0100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000003">
        <property type="protein sequence ID" value="TBU21015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2S8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2S8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0003p0100"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU21015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="436" mass="49590" checksum="94ACB5E47EB82AED" modified="2019-07-31" version="1">MTDLSEEIKNLSISNQKEVYSIVFIGHVDAGKSTICGQILNQLDLIDKRTLDKYIKESIEKGRESWYLSWALDTNPEEREKGKTTEVGRAFFELESKKINILDAPGHKMFVSDMIVGANQADIGILVVSARINEFEAGFEKGGQTREHIILARAGKIKKIVVLVNKMDDESVCWSENRFNEIKSKLSKFLQAIYNDSSIKYIPVSGYKGINIKNRIDKSICNWYNEESFLEYLNKIDFNRERNVFVMSVAEKIKIMGNTMYSGKIESGILNKNQKILILPKNSICTVLSIFDEEDMEIDQALLGDTIKIKFKENIEDVDTGDVFCDPSNHDFKIVNEFTCGLTILESKNIFCVGYKPILHVRMVSKECKILEIRTIINKKVVKKPFAKKGEKILAKIRVETPIALLNCKDEDRTDKFALRDEGMTVAIGVVRNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M395</accession>
    <name>A0A4Q9M395_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0119p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000119">
        <property type="protein sequence ID" value="TBU20172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M395"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0119p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="274" mass="32980" checksum="C0CD0928EFDED737" modified="2019-07-31" version="1">MIKRITKIIFTILLIVFMIPRTLFKNYILEKYLTNLLLTHFLIESIVKKPRFLHSIFSLIVSFPLTFVIPNSISNIIFKSTKYIYFILLFTETLLFYKLLEKEKYLEKKPKYLIRSLIFLLSFYSLFNINLPDIKKLSLNISLPISINLITMIFYIIKGNLFINKKCVDIFYEGIIVKIFVQYYIFLYLLINLYLSIIQNNTIRYHGKWIQIILRLFIFYFGIDSENFKYFKTCVIFILILTFGNIEKSYERYFNSIFIVFLNILMTIICDICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H9</accession>
    <name>A0A4Q9M3H9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUBPL iron-transfer P-loop NTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0049p0070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000049">
        <property type="protein sequence ID" value="TBU20578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H9"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3H9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0049p0070"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU20578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="239" mass="26877" checksum="C1410228F3141582" modified="2019-07-31" version="1">MRKIAIMSGKGGVGKTSFTSLLACILQEKYKVLLLDFDICGPSLIFPFGVSGKVKKNENGFIPIKLAENLDILSMAFMIKESDSVNWRGPKKNILLEMFYNSRFFKDYDFVVVDMPPGISEEHNFLIGKDFEAVLVTTSQNLALNGVIAAYNFCIGADIKIIGLVENMSGLVCEECGTVNKIYSCKGGSLVAEQFNLIFFGFLEFEVEMFNFIDSGKLLCEYKKLKSYNKLEEVIERYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Q3</accession>
    <name>A0A4Q9M3Q3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0085p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000085">
        <property type="protein sequence ID" value="TBU20352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Q3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3Q3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0085p0020"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="453" mass="52208" checksum="EF47FE320EE470A7" modified="2019-07-31" version="1">MPKKIKVCIRIRNTYDDSVWEINNTILYQKIDCNKRLAFDCFQGLFFRHTNLNIFDECLIELLDEFLSGINCTVFAYGQTGSGKTHTMLGTEMENGLIKLSLVYLIQKTTSKQLKASYIEIYNEKVYDLLQNNKEIKLYNVENELKIANLSKIEVESTSQIISILDLSEKKRRVSATEYNLRSSRSHTIFQIHLDLPHVSVKLNLIDLAGSEKAAGTLERRKEGSYINKSLLALGTVVNSLTKSAYVNFRDSKLTRLLQPSLDGTSNVLSLCMISPNNKNLEESLSTLNFAARISKVVLKYKQNRMITVTENTIQHRNICERCKKEMYEESKDEMDLEKSVKNRNEENIDLKSTSKLLQYGTKNQKFNKNGLNSLQKNSLNSSLDNTKIEFQRETMILKSENELLLNRIAILEKMVGSMMNQNTSGRIHEIFLLEKNMFNLQLEMLKRKEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Y2</accession>
    <name>A0A4Q9M3Y2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0107p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000107">
        <property type="protein sequence ID" value="TBU20236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Y2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3Y2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0107p0010"/>
    <dbReference type="OrthoDB" id="6818577at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20432" checksum="A3033DA17A11DABB" modified="2019-07-31" version="1">MNSRCKDLIDMHSQSDDLYKFIHVYQDHLNKFIQLQPLNNKSAEEDAYVFLDIFTIFGAPSILKGDNGRESENNTIKSYMTQENPKHSQRSKQHACSSLKTQTAGNDRRVYTLLRLYKIENIILKVGLGSFLTKNVLLNINCEVDLEILLKYQENLKSVNEGILQIKLADITTGQHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M448</accession>
    <name>A0A4Q9M448_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0092p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000092">
        <property type="protein sequence ID" value="TBU20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M448"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0092p0070"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="174" mass="20031" checksum="90E760A57EA55708" modified="2019-07-31" version="1" fragment="single">TSQDSLQIVETEKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEVHKEPTPPLKEEKREEDGEKKNFKPKNKAPLISQGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4A3</accession>
    <name>A0A4Q9M4A3_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0001p0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000001">
        <property type="protein sequence ID" value="TBU21047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4A3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4A3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0001p0180"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31322" checksum="F530FDE3E0C3542D" modified="2019-07-31" version="1">MKCNNLKCRESIHNRAIITICCHIFCPKCGPKIKKSSMCSACQNFLKEEDILLKEIDVLPCLLGYNPEEIFEAARRGLSFWINQNEIENSIQNLKSDSLESQCMKYKKDLKSLESATKIEMDSLQAKINKLERNIEKERQNSYDLSVMLSEKTKQYQRLVTENEKKYTKATKNNDVNYHTTNRFLFIADLKLLGTDNSTWNHESFGLKNEYTLLLLLDCSRKSNEISTQEAATPKMEVSSKTYFLRKKVIKTTNKAVFCISRIKIYYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4L3</accession>
    <name>A0A4Q9M4L3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0060p0060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4L3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M4L3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0060"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="401"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU20506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="661" mass="76701" checksum="2048782C6F1E8C58" modified="2019-07-31" version="1">MENIFTNKDLLIYIRKKFDTNISETQRLACLFAATQKNLSPDTFGLEIWIMYITMLSCTDDWCDINNIFQVIKRDYYKYTKYWKEYFLFCKKCGDKVFFKAVKQSKAFLDSKEFNSKNEILNILENIINNRDVDSDIDSDKGSNYKGDNRDDNKGIDTCKYNGDTVMDNGTCKDRGDRVMNTYNSKGHKESNNESYNNNMYYRNIKYKNAALNAYSKDCKITDKTYNDINYIYNSVKENYKDNNFKGENKGKNLKGNACNINNPLNNKIGISDINTPLNNDIRVSDINTPLNNDIRVSNINIPLNNSKNHGNIKTPLVNNVNIPITNTPLNVHMKVPISNTPLVTNIRKNNFKENQRGIPVSVDIKNPCDLNITANLNALQGKVPQQEYDNTIYYIDNMSLKVIRQIKRGGSSVVYQVLCNKEIFALKEIKITDKNDSLSKEYKNEIFLLQKFKKSNEIIKLINYKITDTNILILLEYGETDLSDVIRNTKKLSINFIRYIWEQMLLIVEKVHDSRIVHRDIKPANFVFVKGHLKLIDFGISKIIRPETTTVFSENAAGTFYYLAPEVLNNRDKKIKRSADIWSLGCILYEMVYGNPPLYNEKHVTDILCRLNDSSLQFEYKFINESYESVIDVIKGCLVYQPEKRKSLKDLIDMRFLKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M558</accession>
    <name>A0A4Q9M558_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0011p0030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000011">
        <property type="protein sequence ID" value="TBU20892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M558"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0011p0030"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="181" mass="20975" checksum="A2452E4C1CD8EE6F" modified="2019-07-31" version="1">MDYEKMSVTLLRQECKKYGIQASGKKKNEMVECLIKYHEDNKGVEGEVKNNEDVEEEVEEEVEEGMLDNKILKKEGNKAVIEEDNEKSTGKTDSSKKVESMTESEEEKIRLRKLRFGTVDAENTNSVYIERKKPGSKQKSISVVKKEEIKKNDETKSKDTPVFSEEEIKKIEERKKRFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M564</accession>
    <name>A0A4Q9M564_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0030p0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000030">
        <property type="protein sequence ID" value="TBU20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M564"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0030p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="25886" checksum="8D16114557768560" modified="2019-07-31" version="1">MINLFLKSEKGKLASEHCKSKEIIIYFFKKEKKTVGLIHNFKNDNSINFSRQRHTFFDKISINFSYFSKNEYKINVAKQRNIVFEFGWNLNKFISLGIEKELGFLLRNILKMICKNHEIFKLLELYTNIKKFSEKINEDSICNLYIHYNSNELFIYEFIFDLNIYKLITASKFKVNLDKIKNTQFIDYLLFMIYGVTDDNNLSQNLISRANKRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5X3</accession>
    <name>A0A4Q9M5X3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0007p0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5X3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0070"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="417" mass="49091" checksum="91CD72E6A30DB86F" modified="2019-07-31" version="1">MNNHFMDIYSDIIKTLEYINFFHVDISFAWWTDFFESGNAHEIILDFYSIVSQNYFLKAFSDSYSFKDITYFEVLFCCFKISTSFCDSLVRFKSLKTLKISHCFVDSKNENWLLEAIDCMKNFESLSICQNGISNKLCNVIFRNPGIRFLQLESEYRADYMDEEGFNFDFNENYCSLKELVIKYIKISYFSLREIFKLKNLTNLHLESYEIDIPRRSESLFFAPRDINSLYIRFESIEFINRLNILSNLVVVKQLGLFGPGLIPGNISNLCMLCNYKLKTIIFSKVNLNMKDLNRIKKLGVLEKFVLCQTKFLGCSFCNLGDKCTFLYCLKSVIFESVVLNSTDIIYLCKFKKLEKLSLLLCRLNLDLFTFKMWLVSSSLKEICIGETNIFRFKEKQNVPDDTLQSYFKETNICFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M620</accession>
    <name>A0A4Q9M620_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative poly(A) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0002p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000002">
        <property type="protein sequence ID" value="TBU21026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M620"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0002p0100"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="447" mass="52249" checksum="48E7EE3ED87D553F" modified="2019-07-31" version="1">MDDSFIPYKSVNIKSDYSSKTPTHFLYTKIPDTYTKKTAVPQYISPLERLNTELLTLSQTLKPTPTEIEIRNFLISKFQLLFLEKLNLHCTVMGSYSHNLFLTTSDIDLSISCPTIKSDSNQKKEENILLKKICLILQNTEFIEPISIIHLNKARIPIIKCRDILYKIRFDISINNMSQSRYVHTALQKKPYLHNFCLVLKYFLFKRDMSQTRRGGLCSYAQFLLLNHFFNLHPLIQLKTVNPLLNMGVLFMDFFQYFGIDFKYDRSVMISHKGYYNRIEENNTEYRDEGKGEYISDNKGYNRSDNKGYYNRSDNNNTNFNKFYDKSFDACLNIEDPDDPSYNVGHGCSTIQSVKEVFNHCYRIMSVILSGEVDSNKCVLSVWVNLDEKEEEWRRGIVEKYKEIKGRERGMIEGVIYKDSKGVIYKDSKGVINNGNKKRVLLISTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVK6</accession>
    <name>A0A4V2JVK6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0133p0030</name>
        <name evidence="3" type="ORF">CWI38_0014p0100</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000133">
        <property type="protein sequence ID" value="TBU04452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000014">
        <property type="protein sequence ID" value="TBU20875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVK6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0133p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0014p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036360158" evidence="1">
        <location>
            <begin position="28"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="408" mass="48249" checksum="7C8E0ACF39B4307D" modified="2019-07-31" version="1">MVKGEIFLIFVFFLKQIYLSTNDKISAQNIESCGCDDVIYKRVIMFKNKFIERLKKSINKRFFMAVKFTSSTMNLKFTEYTSLYTFWDKSKTSLLYTTVLKMNDNLTDFLISKVKNCNFGDGVDPGNCKQSSYFYRTRKRNLFGNFFEKILKKSIYNKASYSYNDYIISLQKIFSIYPSKLKFDHRRTSSIVVIISDCPIRDYELWVIEKIVSSSVVMGFGYLSTIILRIIDSEISIIKTPKEYLNDDFRKMLLKNNYNFYGFEGFEVELTKNKTNISNSSPKISKYFSFKLRLYRYSLKGFDGFSSNFIYHQEPIFSSRHNVFTYFRYGFKIRVSITLRNDNKLKAGNSVYEDISTYRFKVLRDNYVVFYLHSNYDYLFKRFSISGWACCPGISLKNGIILLKHIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWI5</accession>
    <name>A0A4V2JWI5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2317p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002317">
        <property type="protein sequence ID" value="TBU08022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWI5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2317p0010"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU08022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="94" mass="10939" checksum="74D507836FFD54F1" modified="2019-07-31" version="1" fragment="single">LQQVSKKISELNLKDTLRNIEGNEYIFIGDKNIFYTILDEMYTKCKLSADFGQRGFTGRAFPYCYSEFPGEKLTLIEGTEFENHAMCAIYKMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX18</accession>
    <name>A0A4V2JX18_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2013p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002013">
        <property type="protein sequence ID" value="TBU10112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX18"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2013p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="111" mass="13464" checksum="9D12CB5AC4332592" modified="2019-07-31" version="1">MITMCESIFTFSFFGKKKENIQNSEKDKISEKKDANKSGKKEEKSKSWFEKMKERRNSEKNKKKLKKEEKKQKKEEMKKQKDEIKENPKIYRPNKKDDIDIIKDDKKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXM7</accession>
    <name>A0A4V2JXM7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5094 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0609p0020</name>
        <name evidence="3" type="ORF">CWI38_0766p0030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000766">
        <property type="protein sequence ID" value="TBU12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000609">
        <property type="protein sequence ID" value="TBU12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXM7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0609p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0766p0030"/>
    <dbReference type="OrthoDB" id="2187979at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031519">
        <property type="entry name" value="DUF5094"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17015">
        <property type="entry name" value="DUF5094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5094" evidence="2">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="284" mass="32211" checksum="BF8A6D34D07B34B6" modified="2019-07-31" version="1">MKTPRSRITFKTPKKRNIKTPLSLKQSRESRESKESRESREMTERRDNRDTSLSLKHKDNHTIPTENKKLDSSIISTENTLSSLLESYREENKFLRNLKNDSLIFQRLVGLSIKEVEGKYECTHTVTVKGVTRYIVFLLIPDTSSYVYKPVSSCNVSLPEYLSDSICFTEEHIQMGVRDVLEDMLEKGVSYKESNGIIVKGVLLIKSNIEGVIKGVLLIKSNIEGVAYKEGVTYKESNSLVVKGLYYKGCIEGVIYSSDTYAVSNTEGVNKGLYYKGYIEGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY02</accession>
    <name>A0A4V2JY02_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0340p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000340">
        <property type="protein sequence ID" value="TBU13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0340p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="987" mass="113218" checksum="6C28324EEE473D63" modified="2019-07-31" version="1">MLQPSLDALYQTAGIISPTKILADLNNITETTCMTDTTETTYITDKTETTGITNITDTNNSHKHLEIIKLLILENTHHTQILNHTILYLNTYPLKTPQFITDLTTSPFYIHRLFCICLVTHLLYNTTTSQTIKKTFGGYEDLIICKDENTMDRVGVNSKESIDSNIINNKIISNNIINSNITTNEQSNTNKEFNTNNNNTKEQSNNNPTPTTTNPTPTTNYPTTNYLNTNVFISVLNKDLIFNTTHTLLHDTIEIVSKSQIKSLSSIHHYYPTIFTPKYLLSYINYLFQQSDYLQCCIIYIFNIYNYISIDVLYMLCYSKSWRVRMSVTRKIHQIINSSSMGLHNGVGVDKEVVLDNNNILDNGVGVDNNILDKEVVLDNNNILDNNINDNNNILDSRLDSRLDGNNILDSRLDGNTNQHTNQHNNTTIINSLLLKLACDTEDEVRKTLVNILPYINTPIIYQLIEILSKDSNEQVRGVIGSNIGKYKICSRDSRVDSRVDSSDNIVDSIVDRDTIDNNYISYKYDSRVDRNITNTIDNNPISNTIDNNSYTNPYTYTNPYTDNIPYTYSYVNCIVSVFNRLITDSCIEVRMSVLKGVISLVEKRGKSIILKENNNIRGKYDSIVDSKCDSRVDSKYDNNTSNNNNISNNNIVDNISNNNIVDNTSNNNISNNLTITLNLSLVLEQLQNFLISNKWRIRLFVCDFIKGMICLGFEFFKKYFIKIYYQLMCDKCNEIRMRCFYVYEVMCVEWGISRGDGSNSMLDNNNNDDNRIDNRIDNDRIDNDRIYGSNRIDNDTNNNNMIGNNPITNINNKDTNINNQYTNKDTNNNKESNINNDKSDIFVDRVEELVRNKNYLIRIMGCYYCSKMLYLKRGRSIVEVLLRDEVSNVRCECVRVISKSIYSILGDRIVGDTFVRNNIINDNTLVNNKNNIYDNGVKKQGDNMLSMGEELLGWFVGVLSQMSGDKDESVRRIVESVMEELEKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY33</accession>
    <name>A0A4V2JY33_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0244p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000244">
        <property type="protein sequence ID" value="TBU18372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY33"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0244p0010"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU18372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10538" checksum="166C9C599DA60B57" modified="2019-07-31" version="1">MKKSKEIQKKRINKFPAARIKRIMQSDEEIGKVSTSAPIVLGKAIELFMKDIIMSSVEISKKNKSSKITMKELENLISEVPKFDFLNILINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY48</accession>
    <name>A0A4V2JY48_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0201p0080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000201">
        <property type="protein sequence ID" value="TBU19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY48"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY48"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0201p0080"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="121" mass="14416" checksum="6210AF8DC8FB74FD" modified="2019-07-31" version="1" fragment="single">YNDKTFTVWDLSGNVNVRNFWRCYFMNTKYVIYVIDSNDIARKEIYLSVLIQLSQEVELIRCSFLILLNKSELNMHISIDEIEEIIKKSYSKRKIAVFSCTTRKKESIIEAFDWLIKDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYE6</accession>
    <name>A0A4V2JYE6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0022p0130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000022">
        <property type="protein sequence ID" value="TBU20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYE6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYE6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0022p0130"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="293" mass="33625" checksum="237A7C0F60C5FBC9" modified="2019-07-31" version="1">MNQKKIYITGASHGLGLELTQMFLDEGSVVYTIDRDKHPLEGHERLHHTIADLLKDKLVIPNEEFDIVISNLGTYPGLKYFKELTDQDIENSNKLNILIPTLLARNAAYKKIVFVSSVCSQLGFPMLGLYSGAKAYLALLNESLRREGIKTMIVFPYKFNSGMFDEVKDLFTMRTTDVAKAVMCGIKKEKKEIYLPWFSIISPYFRILPTFLQDWIMKKTASYFYGESMARTITSNGILSCIQENNRNFTSKDGKKSNFCFTRNPFNLTTAVYIIFFSLMLYIGYKNYNISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9KZX7</accession>
    <name>A0A4Q9KZX7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0956p0010</name>
        <name evidence="3" type="ORF">CWI38_1157p0020</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000956">
        <property type="protein sequence ID" value="TBU00599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001157">
        <property type="protein sequence ID" value="TBU11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9KZX7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0956p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1157p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU00599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="110" mass="13530" checksum="4DB8B720372AA265" modified="2019-07-31" version="1">MKFEIQLNFFHRIKDTNNENIYLKCFFYYFSFYDNIAKYQNINYIFFSIYEFFSILLSLIMSNIEDSNKNKKMRNFLIDEERKNKDIEEAANLVVKNELKEIEAFLEQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9L9H4</accession>
    <name>A0A4Q9L9H4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI37_0153p0030</name>
        <name evidence="4" type="ORF">CWI37_1187p0010</name>
        <name evidence="3" type="ORF">CWI37_2846p0010</name>
        <name evidence="6" type="ORF">CWI38_0680p0020</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FI-OER-3-3</strain>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002846">
        <property type="protein sequence ID" value="TBT96648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01001187">
        <property type="protein sequence ID" value="TBT99868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000153">
        <property type="protein sequence ID" value="TBU04314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000680">
        <property type="protein sequence ID" value="TBU12658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9L9H4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9L9H4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0153p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1187p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2846p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0680p0020"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBT96648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBT99868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU04314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="135" mass="15518" checksum="BFDA79A9C0E8416F" modified="2019-07-31" version="1">MSSFTLTITQTIPNPLLSRQLIKVKLAHPNSSTPKKDEITKKLAYLFQTDPSLVIVRNCRTAFGLHETTAEAKIYEEISTLNSTEHSYVIARKTGVVADKVPRRLRKDTRKKKYKMFGSLRRNMRVAAKKEKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LCA3</accession>
    <name>A0A4Q9LCA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0129p0030</name>
        <name evidence="1" type="ORF">CWI37_0130p0030</name>
        <name evidence="4" type="ORF">CWI38_0328p0020</name>
        <name evidence="3" type="ORF">CWI38_0540p0010</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000130">
        <property type="protein sequence ID" value="TBU04483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITJ01000129">
        <property type="protein sequence ID" value="TBU04490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000540">
        <property type="protein sequence ID" value="TBU13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000328">
        <property type="protein sequence ID" value="TBU14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LCA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0129p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0130p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0328p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0540p0010"/>
    <dbReference type="OrthoDB" id="2188105at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU04483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU04490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="228" mass="26290" checksum="BB67D4DFC843BB05" modified="2019-07-31" version="1">MPLILVIAANTEKITQFNTELCNYITETQTNTKSEIHILDGTFLEIKSKLLSLVDCKKIFILNGAFYKSERYEFYCISRRFNTSFLIVHIPDKTINYEATQFTSSFDGPVIDIEHDSQYLDTIVKYMNKNSKSTRAHTSNMTRNNQTLNVSKEESSDPSCNDYLKNVQLAINEIRSTYSDQSFVYKEVLDACETVTIRLVSLNPKTIEDVKHFYSKMVVNELKLKGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LFM1</accession>
    <name>A0A4Q9LFM1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_2498p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002498">
        <property type="protein sequence ID" value="TBU06839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LFM1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LFM1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2498p0010"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU06839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="410" mass="49102" checksum="F15E52A66B3E3D5E" modified="2019-07-31" version="1" fragment="single">KKEESENRKSKTEDNIKAEIKKEESENRKSKTEDNIKAEIKKEESENRKSKTEDNIKAEIKKEESENRKSKTEDNIKAEIKKEESENRKSKTEDKTNEISKQKLEKIKRINKLIKDVNENEMDYGISTKRLAVLNLDWDFIKPEDIFFQFKSFLNSEDELISVNFCKKSNEKDDLPEIGTIKVDGKEEKDKDQMQLRKYLLEKRKCFMVVAEFRDVLAAERIYEICDGLELEESMNYYDLRFLPDNFKLENIIQTVTNTSNYEYCKVPRSLVFQNKIKYEWDVDIKRENFFKKLFEQEIMDERLANKLIDISDENSNQFSNENKIDEPHKNNLETKNNISVKKIRQKEKKNIENKKSKKSEFIFNPNDERFVSIYESRDYAIDVTHPNFRKSERGLKEILKEKRKYNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LG94</accession>
    <name>A0A4Q9LG94_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_2672p0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002672">
        <property type="protein sequence ID" value="TBU05950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LG94"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LG94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2672p0010"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU05950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="185" mass="21795" checksum="449EB908235EB9EA" modified="2019-07-31" version="1">MENIEKQKNTLYISNINQNMNIKEIKRRLLIMFSRFTKIKDISISNRLKMRGQAFISIEESIHVEKCMEMTHGRYFMGKRLIVQYALHETGRKKSDSTNKLKKQIQNDINPTKTLVIRNFDKSIGLNDIIKIFSESKGYLTVRYVSVKQIAFIDFDTPKNALMAYKNLFISIFETFGHQIELKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LGN0</accession>
    <name>A0A4Q9LGN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2426p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002426">
        <property type="protein sequence ID" value="TBU07259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LGN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2426p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU07259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="494" mass="58494" checksum="56935FDB6F195F19" modified="2019-07-31" version="1" fragment="single">MVFGILIYKPKSIYNIQNENVKVNMEYKRVIVLFFCVLNIRCAIKDERIKTFDEIRFEMLQDPFIFYISTYYYDCIRIMVYKKMIDDLFKSFPISEINEVECDLNFFKEHYLTDPIGSDITLYKFFKYFKPKTWEIWSEMFKYRVIYVIFDFFRDYLSEYSVLFNEHPLFRAKTMSFMENSYLKKLDGKGYIKSYGVKELEILIKINTETCDDVTTVLCTDQNTTNISIEDSQVPESNAQSINTPPENPIFKNKTEADSGILPQKQDQTELFSDETTLREISHQNISNPLISSSADVACDNAYKCILLDSLETLFFEVIGFFKKNILHNNHKLLYNFDYTSYKNSNLFETHKNLLKQDTNAKSKSIIFAFFYKKMYGDYQSYLNTMLSHLKEVSSNNFENLTYYFHKMLNSPVYKIGITKDLYYLAIDSKFIPQMNYDEKVLVFDLDDTLFPTTFYLSNTKDFLSSNKNSDFDDSDYVSKLDVKETIEELKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LL66</accession>
    <name>A0A4Q9LL66_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Sec8 exocyst complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_2189p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002189">
        <property type="protein sequence ID" value="TBU09059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LL66"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2189p0010"/>
    <dbReference type="OrthoDB" id="2193852at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU09059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="237" mass="28299" checksum="96D2ED4C20E0B0A5" modified="2019-07-31" version="1" fragment="single">SNGNIDENIILERNIRNEINEKEEGIDKLTRFLMIKSIYKEDLIFKKNEYLKILITIDTFNKLYDLYKETIKGFEKNQVIPELEALSHEFEATIKIFILALNFELIVESMYFYIIFFRECTYDDSCNETLQKIFDIFKEIKNAFKIVQINLDILWCLNPILEIFSKYSIRYVRYLNVNNLEDLNVYIEKIELIEEIFYGLGSTTGMTEWLNILKSTQNNKSTNEEEKILIDKISRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP49</accession>
    <name>A0A4Q9LP49_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1776p0010</name>
        <name evidence="2" type="ORF">CWI38_2010p0010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002010">
        <property type="protein sequence ID" value="TBU10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001776">
        <property type="protein sequence ID" value="TBU10416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP49"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1776p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2010p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="408" mass="46588" checksum="5EABCE62EB97890E" modified="2019-07-31" version="1">MKKNIIHAIKEYVIVFFYLQTIFSGTHSTNNFSCNSNDIAQNTSVSNKNSQIPGQKNGEILNAKRKNTGSAACSEPETLFKSSQKKLKSDGISKHTFRGNHSAYELTPSNQSNPGLTKNNISNNKQNNENRDVSNKKRINKAMICTNTFLSLEPYNKPLDLTAKEPSSQYNMFHNKDSKTREISDTKSTLLSNIPVKNSTFIPPNPEINNVANLSNQNDEISGFLDCKRLVSNLENISKNLQFAITYLNVLNSSVSDETRNTKFDSLNKQAQDLSIDVKCKNFYISTLTSWNLVIKDPKYQKNHPYLNSLYCFLKESRDSSKRASDYLRKMCYLKLIDSYLKKEINSLNGIKLLGNYDNMTDIDILTIEFLGVTQILCRNRFLAFIKSYREDEGFRKVVDYCNVQFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPA3</accession>
    <name>A0A4Q9LPA3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M1 aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1911p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001911">
        <property type="protein sequence ID" value="TBU10249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPA3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LPA3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1911p0020"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="221" mass="25201" checksum="B931CC82483C9CF2" modified="2019-07-31" version="1">MNLEAYIQSIVVKKRRASMGVIMRGEMHDEPTPPLKQARGTTLEEPTNNINEESDLEEETKVVKENHKEEKAILKFPQIIEPSIIKLEIGFTRTLKTNINGFYIGNCTIKDKKSILLSSHFEPTAARQAFPCFDQPDMKATFNIKITHSKELTCLSNMSVKTEEINENFKTVFFNQKPKMSTYLVAFAIGNLEFIETESKNGVKIRVYIPKGYNIESGKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LPU2</accession>
    <name>A0A4Q9LPU2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1715p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001715">
        <property type="protein sequence ID" value="TBU10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LPU2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1715p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="452" mass="53070" checksum="A8A402C35A8738F9" modified="2019-07-31" version="1" fragment="single">KCCEDTATLLEGVSIYKYLGIIEDSRGIPTRSSFEEVQSKLIAKVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLELAYFSKLDDAVRAVLVKNKIHLRPSCKERLYLPRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRDEAMFCYIQDRNVFWGADGMYQHCNKSGKTVDHLATRCEKMLSHDYTRRYNEVIRCLHLLLLNRYKFKSSKRIKSHSVQEIFDNEKYDLLVNELGLIYNYSVEIILYMMTWDGIVTKYHKIPRKRLEIHMNVEAYIQSISEPNAEESWERALMGFIMRAEMHEEPKHPLKEAKNGENGVKEIKKRILHLFFQREEPTNNINDELDLDEETILVKELEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQ90</accession>
    <name>A0A4Q9LQ90_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI37_2230p0010</name>
        <name evidence="11" type="ORF">CWI38_1651p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FI-OER-3-3</strain>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="PITJ01002230">
        <property type="protein sequence ID" value="TBT97495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001651">
        <property type="protein sequence ID" value="TBU10608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQ90"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LQ90"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2230p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1651p0010"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033831980" description="Serine/threonine-protein phosphatase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="330"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBT97495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU10608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="508" mass="58903" checksum="F8A5776AF5042733" modified="2019-07-31" version="1">MFTFVFFVLLFILFEEIGKKDSDPFLKMKIDIYAIRAKGNNFFKTKQYDKALETYYEGIECDTTDFPHANKELSILHLNISVTHYLMENFAESSRHALESLKYGRSNKAIYKLCNSYLKLGRFYQAKMLFETKGREFGEYRDPIKDSEKNFGNSELEYSFKGGISNYIENILKNFSLTSTSPFNKFFENIENNTEKTPFLKDEPFFTIFIEDSNILKYSFLNIFVTEIQKGNYVPAKVVVYILRYSYSILFNLDNIVKISNKENQRIIVFGDTHGNFIDIVNVLQQLISGNSKDIYLFNGDFVDRGSLSVENILLILVLKMVFPDQVFLNRGNHEFPAINQMMGFYEEIKVKYSLTHNIIFQSFCEVYKCMPLASILNNSVFVVHGGLPEERFYINDAQKIFRHTNDSYDKIFEGFMWSDPMEGFGVTPSKRNIAVNFGKDITERFLRDNNLTLIVRSHEYVCGGFKINQNGKVVTIFSAPNYCGMKGGAAYLVFEDKSDKYKVVNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LQP6</accession>
    <name>A0A4Q9LQP6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1544p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001544">
        <property type="protein sequence ID" value="TBU10798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LQP6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1544p0010"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12000" checksum="8CC42CED10897B9C" modified="2019-07-31" version="1" fragment="single">MNKHISLSLPFFVLCMNSLSRKLNEKYTKVTIQRDAKSHSTNHLLFIDDLKHFAIESKRIFKKIQQDINKKKSATNDACHEDTTTILEGVSVYKYLEIVKDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LR01</accession>
    <name>A0A4Q9LR01_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1477p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001477">
        <property type="protein sequence ID" value="TBU10918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LR01"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1477p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020329391" evidence="1">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="259" mass="31360" checksum="FD02802D65B2F743" modified="2019-07-31" version="1" fragment="single">VFFGMSSIIILVIFTLYHEYLEKENNIRKCIQKGLNGIHISEFEEQFEIFKEIRKNEIFLIIKFKDQFYVNKKAKNSSIYMSQINFKRILGSMVESENLNLPTKMIYRDRLVNSFTKISFVRKYLLDKNNFTRLFSYSENETHNRKRIRKFLLNAFNKFNKNLYYINKYIEFKTNFKRILDLTQEIPFDHNFISIFGQKDILNISCIIFYPNKITIYLPEINSDIDFITFQKIKVEVERQDFDNFHSSIFFYVMSTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRL7</accession>
    <name>A0A4Q9LRL7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_1488p0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001488">
        <property type="protein sequence ID" value="TBU10897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRL7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRL7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1488p0030"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU10897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="74" mass="8285" checksum="536F361DBE3A2BEF" modified="2019-07-31" version="1" fragment="single">MSALFNFDSLMRVSVLVICTSTYIKKHFPSMISKESKGISSVFYKSSVIGERLSPYVSITCIVFGFMSLKSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRX4</accession>
    <name>A0A4Q9LRX4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1897p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001897">
        <property type="protein sequence ID" value="TBU10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRX4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1897p0010"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="169" mass="19908" checksum="7CFD67A716847A6E" modified="2019-07-31" version="1" fragment="single">MQFRMRNGENINENNTNRKLNYSMFPNGSNKKIFSQQGIVSSNPFFDRRILHNHFNERFINKRIIPNKWYDFFPGRIVNNETIRNLNERTKPTTCNSFKLKDEADLLLDFSRSISIEKKFKVESNSNINVDYLNCKSELANSEYFKSVPESPNLNIFHISDNDQSVCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY4</accession>
    <name>A0A4Q9LRY4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome biogenesis protein Bms1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_1271p0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001271">
        <property type="protein sequence ID" value="TBU11313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRY4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1271p0010"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="3">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU11313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="732" mass="84254" checksum="CD3C656CC1855966" modified="2019-07-31" version="1">MNPQPPLPNMHFKDFPPPVVTIFGPPKSGKTTLFNSLLKRYSIKTANSPVTFTTSNSRFTFLECPSDIKSYIDYSKISDLCLLVINITSLETDTFEILSLLKIHGFPKIYIIFTHGDQLSSSNQRKQEKKIKKRLYQEITPGIKTFPMKHNVHKSISKYTNLSKLVLSLSSFKPRPLAFKSEHPFIIVDQCVSSNTFYGYLHGTMLTHSYAHIPGFGNLEIENVEVMEDPCPLNRSKMGKNKRYVHPSPVESVSEEKEENIVVEIPKTENETINLFGNMEIEIPNNSEDDSSSELPEDSSEVNVNEEEESLQDSITTSEDISLRFKKNNLEEESISSEEVENPKYDDLFGKEKAKSDLQHEKNISKFSSLKSVVPGNYIKISFSNSINEIPIFIGFYNLNSKTLVMGKIKLNRHHKILKSMKPLLISVGWERTIIKPYFSMSEEKRNRYIKYTPKGIFCSLNYKGYSVTPGSGICLIADENKKDFRISASGIVTDIGNNNTLVKKLKLIGYPHKIHNNTVFMKGMFNSGKEVCKFINGIIKTVSGIRGQIKKNVGDEGLCRCTFEGQLVMSDIIFMRCYIPVTIDEEFINENDKIYEKNNFETEKNKLGNLDENEDYMGEDIDVKVGKYRNEDCKNFRGKKIPKSLESKLPLNKRNIKVWDGNFELPKFLDDDFVEKERERQMILENKKKILEEKIKIKQDKRTEELKRVALKKKIVTNILERTKKRKRRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LRY5</accession>
    <name>A0A4Q9LRY5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1287p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001287">
        <property type="protein sequence ID" value="TBU11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LRY5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LRY5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1287p0030"/>
    <dbReference type="OrthoDB" id="2191972at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="206" mass="24513" checksum="031970A39E7C82A3" modified="2019-07-31" version="1" fragment="single">LESNLGVKNSDPSKQVEFIQNQFKSIADYEKKVAANIETFIQSSLDNKSLQKINVFDNLLRKFKFIESDFDTLMDNKVDKNVYYDIIFKLKRYLEKIKNNIFSLEKSKALELYKNVSQLEYFFRTESEDVDVNVQNFIKSEAEEMKKNKQSDCKDLLTLLILKHINIILLDYSNYFKGTDNKHNEESDLEEENIYNYENRFNPEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LS04</accession>
    <name>A0A4Q9LS04_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_1155p0030</name>
        <name evidence="3" type="ORF">CWI38_1875p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001155">
        <property type="protein sequence ID" value="TBT99969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001875">
        <property type="protein sequence ID" value="TBU10290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LS04"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LS04"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1155p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1875p0020"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="81"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBT99969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU10290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="366" mass="42957" checksum="5CD1CE6652FB125F" modified="2019-07-31" version="1">MKDLNMETNLLYDSSTFSRNRNKKYKNWHKKIYSNTYNSTDYNNINTPLNYLCCDFYSSNNKSLIGNPMAVQEIRLNPRPAGLINKKNDCFFNSVMQCILSLHPLTSFYDSNVFNDNQKFSKSFQDFIRIYKSKSVVNPSDLINVLGRKIFILDSNQQDCHEFLTLFFLHLYIELNGKVNDLISSLSEFDKKKQENFIARTFFGLQKSIVICGMCNQKKEKIEHFSCLTLKLENSIYESMKSYEKEEILSGDNAWKCDFCGKKNKTTKLMQIVEYPKILIIQLVRFYSHTNKDSRKIDVDGILQFKNTKYKIVGYACHSGTVRNGHYVSFGSRNGEWFYFDDEHYKKQESIKLNETDAYVLFYIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSJ1</accession>
    <name>A0A4Q9LSJ1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1707p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001707">
        <property type="protein sequence ID" value="TBU10515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSJ1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1707p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14715" checksum="ABE2335AB073E0D2" modified="2019-07-31" version="1">MSLLHCNLILNDLNIIKNFEVLEDLNLTGCKFSNFGFFRLGSDCAFLNSLKILNLSDVEINIIDLSYLRNFKNLIELSLKIHGSNLLTEKDCLIYLFSLKLLSKSKIKLQININILYKYYMKELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR9</accession>
    <name>A0A4Q9LSR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1264p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001264">
        <property type="protein sequence ID" value="TBU11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1264p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020324788" evidence="1">
        <location>
            <begin position="28"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="485" mass="56839" checksum="A8847B2D2D6B311F" modified="2019-07-31" version="1">MKINFEKMCMKCPLMLLFMIKCIKLAAFQSEEEYFNQLVKGINELGFHEKYADIFANLHDKSEVSSVFFKIQGLLFYVPLFIFNKEDADFLNEETSSSVESKDKDSQNLRSKNLMRILTRSDLNIFPEKGTSNLQKNILLDFIIEYTNKIDEMFSETECDIVFVKHTIGSEALEITMKSLSGEFEKKESFDIKKVQEKLKDKNIGFAKFIVFLMNKSLVRKIQEQKLENLLFGILKEKFKLIFKKPRLAPLPQLELNKQANEGGDITINVSLNLGSISKKLQKEDFSDMFKEILNENWSGYCQNRELYELFLTNPIILLKYNLLLYKTEISFFLNFILRKLTSSSSISTNYNVIDFLCQFVELLPQPIFSKIYRILEDTYQNFVTDKSDRVDKEKNKTAVNNLEEMIYYMVSTNEDNTMSILLSKIVAGLFYFFEHGDLKHTEGFSKVFDERFSNIDFYQNLVKNIKSLLIVYSEFSRLDRPEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LT94</accession>
    <name>A0A4Q9LT94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit zeta of T-complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1174p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001174">
        <property type="protein sequence ID" value="TBU11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LT94"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LT94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1174p0010"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="137" mass="15391" checksum="99FF601ED2FD1990" modified="2019-07-31" version="1" fragment="single">EMERVISGIKSTLKSLSFIIRDKVFIEGGPSLYLKLSKFMESTARNVSEKEVAGCLVLKDVMIKMAKILIKNFDGSVEENIVKVEKGQWERVIDNYIVVNRVIANACVMSVSLLMVDEIIKAGKQLREDNMNGKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTP2</accession>
    <name>A0A4Q9LTP2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7769 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0945p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000945">
        <property type="protein sequence ID" value="TBU11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTP2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0945p0010"/>
    <dbReference type="OrthoDB" id="1734867at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056671">
        <property type="entry name" value="DUF7769"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889:SF7">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24964">
        <property type="entry name" value="DUF7769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7769" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="82" mass="9535" checksum="3391A0B6C237BA91" modified="2019-07-31" version="1" fragment="single">MENVEGNLLNSEKRDSKYKQLTKEQRQGILEKLLQQMKENKLKHGAINKVSYAFQVSRLTVSRIWHAAQTQYRKGKICADVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTQ3</accession>
    <name>A0A4Q9LTQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1152p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001152">
        <property type="protein sequence ID" value="TBU11536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTQ3"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1152p0030"/>
    <dbReference type="OrthoDB" id="2190092at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="446" mass="52077" checksum="989A9ED6F7C44BFB" modified="2019-07-31" version="1">MKIFDSLIILNSMATDYLIIFLHGINSNGKDMSNRFIKFSESHKNVMIIIPTAFPLKVGLYDNKSVNSWFNIRNRSIFAKEDTQGLNESMDKILKLIEYYKFDSEKVILCGYSQGATMSLYIALNCDYKFRIIIAMSGYLPRVKHRNTHRQNILLTHGKKDTVVPFIAGWMSYMALKCLKVNVKFIKFDGEHEFPPDFEKILARYLTKEQRQGILEKLLEQMKENKLKHAQTQYKKGKICADVSSKKKKRCGRKSKEYSNNLAQIRNTPLNRRGTLRSLSFAIYIPKSTFFDIFKISSTVKPTLRDKNKMDSLKFCLSKVNLANNGDLLFDDLYDYVHVDEKWFYLTKPFVYKEPAQINSKNRAKGTIITKNMESVTALHCKNMMIDNVFPQLNLNLRQHTERKQFTYNKTMQNPIFPIMMQILSLLVLLMTKILNLRRNRQIAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTR9</accession>
    <name>A0A4Q9LTR9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1458p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001458">
        <property type="protein sequence ID" value="TBU10960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTR9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1458p0030"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="117" mass="13557" checksum="6BE201BF4831B1FF" modified="2019-07-31" version="1">MRKNKITHIEVGITSQYSVHTVKTEKLRNYGLVENEEYSYVMTWDGIVTEYNKKYTKRLQIPMNVEAYIQSIVLKETAVMHKQLKLFLKQVDNEEAGVKTENTKNITSHMSEGGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTY2</accession>
    <name>A0A4Q9LTY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1107p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001107">
        <property type="protein sequence ID" value="TBU11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTY2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1107p0050"/>
    <dbReference type="OrthoDB" id="112314at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="92" mass="10921" checksum="BDC68366503B6ECC" modified="2019-07-31" version="1" fragment="single">RIHHYRGLNDDEEIASYRIKYLPPYSPFLNPIENVFSVWKNKVIRGGARTEPQLRILIYEKFNEITGEHCSSFYRKMLGYLQKAEVGQMILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUG0</accession>
    <name>A0A4Q9LUG0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2 14">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CWI38_1320p0020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2 14"/>
    <dbReference type="EMBL" id="PITK01001320">
        <property type="protein sequence ID" value="TBU11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUG0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUG0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1320p0020"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 14 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="198"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="451" mass="52691" checksum="CC14DD5C13468387" modified="2019-07-31" version="1">MKNIATKNLEDQVSNTTDELEVKSRDKDSIVNNEDILIEKGENTVNIEDEIIHLDQKESRNITNTINVEENKKDSNKNTHTSSSSMNLEENQKDSNKNTHTSSSSINLEENYKDSNKNEETSSSSINLEENLKDSNKNSKNIPTLVSLEDDNKESLYAKKMRKLNSMESRAESSRVNRKIATHYDKIQKKTISERKNSKIINIITTNNFIKTILLNKYIKERMDVLDMGCGKGGDLQKYKYLRIKNYLGCDISEESIKEAEKRYLNIKDKYKAEFMLLDVYCQEINLNRSFDIISSQFSLHYGFRNSVTIDNLVKNISFHLRENGYFIATIPDKVTLLNRLKKYGNNYGNEFYKISFKIEKNEELSEYLFTLDGAVDSCPEYLLDCEILKSKFKNENIHLIEEKSFLNFFNENIRINKNLYERMRVKRLSIDELKVIELYKVIVFKKTKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUH2</accession>
    <name>A0A4Q9LUH2_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0948p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000948">
        <property type="protein sequence ID" value="TBU11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUH2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0948p0020"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="91114" checksum="967862D6444776DC" modified="2019-07-31" version="1">MNNFEDLKLYFMFNMLYYLILFQYIIANNFTYSFERNGNLEILFFRINKEESAFNTLAPNVCDLYISFHELFESNHEKTRVFTYEKNNFIGFEILNDFITSSKSLHKYERGIIQCNFELSYILRLSKDIAEIPCVLNNYQFSCILAVLKRLKAVENKRLFEFIKFLIITDFFLYNNCLNIQEIFDWALSLEINVQSSNIILSIIFNFLMLAHVFYDGNLIILENTSEIYDLKVFDTQVLYKSLLVNNIKVFYILENALKNPQILETFKSMFFMLNIRSIILYNNQRSKILESDFEFPMFKIDGIKSITIIDFREFSSSLFLKRLRKHIRKDLEVLKFQNTYIDISTLTTILKDQRFKKLVLNNGGIPVFFHLSNNFTGLNQSLKCIDFRNVTVDLDWWKKFFMEANVDKIIIHFSIQFAQDAFIMAFGFVPFPSSNNVTYFKVIFDNPQIPTSFFGSLSCLKNLRTLKISKYLVSEAIHSRLFEVIENFKVLKCLVLRKYGYSKKYYISLFKNPAIENLHLESIFQDSEIFIVDFLNYYSSLTKLVLINIMICQSSFIEIFELKKLTSLTYRSCIVEPKINSEPFCLKSKNISLLTINSNNLNDFKTIDLLSNLETIENLNLSLCNLPSGYLSKLSLLCNLSLKILSYEFNSLNLNDLQRMGKLETLEELNLRGCKFIRINFCKLNCECKFLYSLKKLDIWLVRINNEDLKFICNFRNLRNLTLTLSGLDLYALEDCPILLKIYQFSTHVNIADRGFIKLFGCLNEKGIRVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUL5</accession>
    <name>A0A4Q9LUL5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STE-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI38_0976p0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000976">
        <property type="protein sequence ID" value="TBU11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUL5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LUL5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0976p0010"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="342" mass="39047" checksum="176E61D065CEB7CD" modified="2019-07-31" version="1">MNIQGDKDLFTFLSNAPKEFREGEKIKKYQLKNGDYIHCVLWNMHFYITGTDIVKILVWRFQNAGRQLVSLKKFEEGVFSDLRNLKPGIDATLEGPRSDFLEFLYKNGCIRTQKKQKVFFWYSVPHDALFCDALERDLRRETNLYTYSKYMNNLARQNYIPMPTYSNGSSVGGSVGGGSNSVGSVGNGSVSSNTFGSNSNNSNSVNSNNINNPYSINSNNPYNSNTINSNTLPLTTLSSHTKNFIDPRKKKKDSDILEPFRPETPVPFSMPEFNIHDEYTFNELEFTTFDEKFFTPESSNSYSLDLYKKKEDKRNNSDNQDNGYAPPDMIHPIPNSHGKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUU1</accession>
    <name>A0A4Q9LUU1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0936p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000936">
        <property type="protein sequence ID" value="TBU12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUU1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0936p0020"/>
    <dbReference type="OrthoDB" id="2191051at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="335" mass="38965" checksum="4DE6DBCCC17B6276" modified="2019-07-31" version="1">MTMNTDDKVIFLSDITLEEEYEILQSIKRAKPVEIPPVVQKRICGNSLLDDKDYLFQSINFLWKEQIYDRNSALSSIVFCLLACEPFSNLLKILSTKNRSTKKFFPLAEILSALIDFLEEEKDSKSFNEIREKLVKIIPDGDKKDSSMIYKSILDILHKEFLSSYYFEEVDWEIQEEEKLSKIHIYEEYSPIVEIFQGKFKCLEKELKIKYFESLNIKQSSKDEKIEKILEMYEVSTDKGLRYENDIIKGVESTPIVLVANLNSAKNDFISKNIKFAGEKYKLVSVLSKSEDSYISYVLSGTEWICCLGKPSIFDSVSKFKGFPLMAFYVKNHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LUX2</accession>
    <name>A0A4Q9LUX2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0875p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000875">
        <property type="protein sequence ID" value="TBU12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LUX2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0875p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="769" mass="91404" checksum="A6690BA01906E93C" modified="2019-07-31" version="1">MLGNSTAKILMKSIYNEKTSVVLIIVILLPFLKANNKIVFHFYDEKYVKQEKFSHTDRSALTPSKYVKMKFNDHEHSKCIECRKYIIADKNDFLLNFKNSDTDKSDIIIYLNQKILAYKDFLYFLKILDGASEYKENFIIHDFMRFLHILDIFKFQKDKVFHRIIRILLLSTIFNRNGSHNELNSDIKICVSPSLLNIIFYEFGKIKFFGKKIFQENKSESEVKRILNQNFDLSYSPHTEFIYMNSSLVYKIKQSIKTNPEFIYSFELIFAKFTFRKIILFYDKFICEIPCSVLNILFSCVEEFCFYYWNDVFSFETITEILVSKVLRNLIFIRCRFHSFSETFFGKLRSLESIYFYDSHFKRIGFPNQFYASLNALQNYIFTEITSYENTSNLLEKSNLEPYKITCFNIDLVTKSNKDLITIHDCQPNVFKVYSYNILCFNLSIFTFYIGIINLDKIRKVNIFLNNVLIKGMMLSNSSINLNIQKLQISDSRLTDNFITNILMFPNLKKLFILKCTILFPKGKYTNNESLRKVFLSGNTFENSLYIFYFINSMPNLKSLIYIRNSSLCLFTYPDTEKFLDLKYLQKLKIIEKKMFKPSLPIISRFESLIELDIGNGYEEGSLLKFFLDKKLPFLRNLSINRFGIGIHDKQALKDCTKIQSLCFLDCKFIKISFSELFDIKKEYLIDNIFFYDNILTKNDIEFLSNLKHLKSLSFEIKTSFSFPIEWFKYNLMKIAKLQVRIEIPKDLYQELNQFKEVINSYNLKIYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV10</accession>
    <name>A0A4Q9LV10_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0900p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000900">
        <property type="protein sequence ID" value="TBU12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV10"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0900p0010"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="790" mass="93555" checksum="FADADC7B9B98A1FF" modified="2019-07-31" version="1">MSSKNIFLSMINKRYFEKKMLYNIISIVYTLILLDFASLYNFSYRFTMNKESEILIFDEKQHNSVFFQDDEQELVFDILYSTESILYDEKLHVFTYSKGNIIEFEALNDLFGSDKNEILGRKIECNFNLRYFLKITKDVTAIPDKIDFEFVKGIIMVMKILKAVENKSWNLYFQALFFKTYRFYEKSSIGESEYKFHKHLNQNFWRQVGFDTKQNLTSALLNSLMVENILFDGNLILLESSQATYDKSLLDKHIPYKNLLLNNHKVLYTVENVLKDRTILSMFEVLFDEININSLILGNCHNFKILDDDFPFYVFAINSFKSITISNLEKCLSSLFLNKIKLVTEKNIEFLSLRNVLISKSDLSFICNTYILKGLVLNNVRTSEDFDFIEDYSDLNKTMEYINLKNVEIDYKWWNIYLETPIASKIILSLNTYFSQKNFIAKFKNINVLHCEEVLYLEIDFCYSEIFNHVCTKLFFFKSLQTLKLYGYKSNVNTESCLSEALKNMKALEFLYIKQYNFDYSCDSFVFEKQGIKILHFECFIFMKEFVMIDSSNIYKSLNKIVLKHTIIGESTLLIIFQLENLKFLSLKSCNFEPEIKSQSFHFNLKNLISLSFSKSNLKVFNNIDFLSNFDNLEKIDLSKCKVPCSYITKVSHFCDLRLKKFSYISGKLDLHDLNRMKNFQVLKILNLSKCKFVECNFSKLGDDCRFFNSMEDLNLLFVKINLEDLYYLRNFKKIRNLSFSSSNFSLVAEKSVLVLLPIKQFSTEIDYKDINYKNRYKYLYEKNINVDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV19</accession>
    <name>A0A4Q9LV19_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Erv26-like transmembrane adaptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_2778p0010</name>
        <name evidence="8" type="ORF">CWI38_1113p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002778">
        <property type="protein sequence ID" value="TBT96730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01001113">
        <property type="protein sequence ID" value="TBU11621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV19"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV19"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2778p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1113p0030"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBT96730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU11621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="175" mass="20140" checksum="EC4A29F412665156" modified="2019-07-31" version="1">MFLIFLNSILILLGLIATIIGLAVGLYKAVQFIEDKTYAAKKRIENIITAVSIFHIFLILRKFSLFLVGFSLCIQFLFYSLLDIYPAILPTNIYFVVGSLMAVINHFLFLRALVKGDHYILEMIFYFIVVVWLTPFCFFLSLSANDETLPVKGTKTKTRAGELIKRLFDFSEFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LV87</accession>
    <name>A0A4Q9LV87_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_0867p0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000867">
        <property type="protein sequence ID" value="TBU12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LV87"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LV87"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0867p0020"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="542"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="542"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="594"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="598"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="94542" checksum="DBD0FB7B2B9ECF7A" modified="2019-07-31" version="1">MHKREMQVEEEREGKEVCVGLSKEVCVEEVCESMESSNSSNGSKDGNSSKDGNGSKDGNSIRDSNSSKDCNSSNSSKDSYSIRDSKDDKESFKDNTKQIPRNLMRDSIRDSENPSLYLSKTVFTDNKNGCYNTKYYEHLTSFEKSIAKILVTLSGSFKEKRSKSVTEIRGYGRVEGYRGIKGSEGYRGVSDMEYDYRGVSKRGSGLEGVSNMEYDYRGGSKRGSGLEGVSDMDSNYRGVSNIDSKYRGVSNMDSNYRGVSNTTDKQQGVTNSTDKQHPFNNSTSNQQGVGYRMTNYCNYRGVNRQRSGSVNYSINNYKDYKGVSDKSISYLSKSEWEDKMFYSKSDKWDIDMKGGINNKDKGYKGVKDSDYKGYKDSDKDGLSDGYKDKEYNLEGVSYKDGCIDTQHPFSNSTSKQQGVNNNDTYKDTYANTQHPFSNSTSKQQGVNNNDTYKDTYANTQHPFISTGNRQSHNGRRSSWVGVEDKRGVNYIRRGSMYMDRCYEPSNSKISNNSNISNTISVLEDTKSCTSVDTPLCSESDILPIITKGPWSEEEDNKLLLLIKKYKPKNWSFIAKMMKTRVGKQCRERWHNHLNPDIKKGPFSLQEEEVIMHYHKKIGNRWSEISKKLPGRTDNSIKNHYNSSLRRSIIRVLEYSSSGVKGMVIVVVIRVLEYSSSGVKGMVIVVVIRVLVYSSSGVKGMVIVGLEGVSYIGIIKGMVEGSSYKGVSYIGSSYIGGYYKGYVYGGSNVKGMVEGSSCVKGMVIVGLEGVSKSIDDYKGNIKGVSVYMIYVLKGFYTTDMFLMYKGGVKQKNIYIVFKGGVKQKNIYIVFKGGVKQKNIFIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVC4</accession>
    <name>A0A4Q9LVC4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1146p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001146">
        <property type="protein sequence ID" value="TBU11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1146p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020232670" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="62938" checksum="2D05A73BFBAE5203" modified="2019-07-31" version="1">MNINFLLFFSFFCKFQATKYFWTQKDIDNDHEENPSNLKKETLFIKAVQHLLKENSTVVFHSNKLSDVYDFHCVGEIGMRILFEEIQNFVEKCTKKDIFTKSLEIFQNRQKTEIIINSFLIAYYISFLTLLESEIFNLIYKFKAFNSIKIVHNSISRFFKTKSSEYQNLIIDFVTENKIDLENIFQNKKSKKIIIELKKYDKLRNFIFSNVIEICIDLFFSYLTLFKDIKTFYTGCFGNNYTEFFLEKEKCNNFFVKNFEQILNKKYFNLKIFQLEKLESKCSDFKIISERFDFLKAFLRVKILKVEVNQHHACYSFISKNRISRPFFYTSDPGNYFLKETSKLFIKTLNLEIYRRHEINHYIFIDPENHLLYIFMLRLFKTFRTAEKFIISAGNSFTSKNLFLNDQIRNFLAENKLGCFFEIYMLKEILNFYREKSNYKFHLYLFLYKIPDEAFLVIFNSIIKDPELFTFGKRSNYFFRNLNFTKNYIFECLRFKILMILKNVELINLASSDIEVITNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVN0</accession>
    <name>A0A4Q9LVN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0638p0030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000638">
        <property type="protein sequence ID" value="TBU12763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVN0"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0638p0030"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="256"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU12763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="492" mass="57778" checksum="694B93415F739F38" modified="2019-07-31" version="1">MFGMIMSTQDSYKETKEILDVTVFNYASIVNEKNKNNIFSYIFLKSNEYSEPIMKDYILLFNGIKYNSDISENKFVSKIIEMKIFNLNNKNCICDCDIFQDIEKYNENNYLWDKVNNNFENPKNIRFDIGLELTFIHEIYNEINKDIADYSTILFYKNFIYFFKDDIGKKSLGFSINNGITVSSFDFENEVDPSFLYIYSNTAKQLFRTKKFDFYFSILKNSTQNIFLENETNYVNIIENQLISSMRNFNIKSDCVVFFSGGIDSMILVIILNQILPENICIYLINTSFLGDKKQFDRKMGILAFKELKSNYKNRKFIFIENNIDNENILKNIKIIKNLIFPKKTPMDLNIGMTLFFTAKEASKFSKNCFVGTGADELFGGYKKFRKDFTKLKSMIFDEVSGIWDRNLGRDDRLLSYFHIEPFFLFLDKNFIEISLQLPEDMLINQNSQIYGNKYILRKILIKHGFNRVAGLIKKAMQFGSGAYKVSSLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ2</accession>
    <name>A0A4Q9LVZ2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0593p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000593">
        <property type="protein sequence ID" value="TBU12893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0593p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="603" mass="71908" checksum="AA9CD03A4AE12E78" modified="2019-07-31" version="1">MSLVFWIYIVSCSRVINIIRNGSRFRNLHRSNRFTSLSKNELSANEKSNIDETKKPASLAAKEIDPVYKSLHEIKLLHKNVTKNINFIPSDNERILPYLRFNIKCILKKERKNSKNYLEDCDFENQFLKVAYPSRLYVEKDLDLYNSSTKELFRRKRSVSIKPRILSKMINTFFEKSQDESFNVSNRNAYDFFDFKKSETLMNIKNAISDTENRLAQNGTSDSLKWARFFQDSEIENLFIFYLLLVKYSNKKQNMDEFLSKNNLDLDVIQSKIEEIKSSHFDGFDFTETFDLNFYDYNYFFDASSEFYEDSLKLLAKNFQAINYDQFGNMNESFLSEDKFNDVFKKKIYDHKIPLDFLTCLRIKKETTDILIKRLFLEVQTVEMIMKLYDTLFLVYSYQRTQMDYVQVANFIIFFAKDIVKLFEHEKNELTVFLTLICNLRNFSSSCAEIASFSDKPVKTYVNLSVIAMFSQLKIEDQNDVVIAALRNEILENFFVRYLYGRNTWLNNIMRQESASKIFFEFKYIEHLFCRFGIYSSKNENYCSRLFKYLLNNNIYISEIFDRDELLDVIRLLRSNIVFGINSYECGELIRIIEYFLEHESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ4</accession>
    <name>A0A4Q9LVZ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0780p0020</name>
        <name evidence="10" type="ORF">CWI38_0635p0020</name>
        <name evidence="9" type="ORF">CWI38_0714p0020</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000780">
        <property type="protein sequence ID" value="TBU01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000714">
        <property type="protein sequence ID" value="TBU12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000635">
        <property type="protein sequence ID" value="TBU12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LVZ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0780p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0635p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0714p0020"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="219" mass="26517" checksum="F2E9423F950EABD2" modified="2019-07-31" version="1">MKDIKKSKTMQNDENPKILIDRYGNPLGTPPEIYKDTRNMLQSKYEGDTHTNSRDILFQMREDPYKFRQNYSEDKRQEFSHRPEDFNKYRTEFQDDKRQEYPIPYTYSENEYPYDAQGKNNPDIKYFTPDQYYTNFENSFLFEGNGEQPLYVNVHQYNTIKKRKLRRDYLDSLMKTKNKAGYLHESRHRHAMNRLRAPSGRFLTKEEAAEQRMKNNGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LVZ7</accession>
    <name>A0A4Q9LVZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0952p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000952">
        <property type="protein sequence ID" value="TBU11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LVZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0952p0010"/>
    <dbReference type="OrthoDB" id="2195607at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="241" mass="28692" checksum="A84DE5F177FEB77A" modified="2019-07-31" version="1" fragment="single">MKSNLPASNKKKYRKVNEQRKRFNCRKIENGLKVIEKIFTRPELNNEEVKKEMKGSKNEICKKKIETRCGFSYINNENNNCGKIESNLKNYNHNDEENEFGISQKRNEANKYCEEQENKSKYSIPVNQLISKNYYFIEDENKKEHSISVDHFIDNNENIKKEGENQMEQIIEIRKLIKENTNSNEYNKEEESIMVGNFMNKKNFAKQTNQSIEKSKNVMRSKSPFKFKKHISSDEMYIVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW20</accession>
    <name>A0A4Q9LW20_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_1000p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001000">
        <property type="protein sequence ID" value="TBU11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1000p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="593" mass="69626" checksum="C314FDE5784372D7" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEILMNVEAYIQSIVLKKTVETISFDRRRGIESEPNVEESYERASLSVIIGAEMHEEPTLSLKEEKREDYGGTTLEEPTNTINEDSDLEEETKVFGSDSFNDKCALENLDSKCIGTVQSNAMRSIEENFHDENFISNKAVQYSQTLNSENSMDYSFRFNKTTQGAEIDQNSIFNSENYQNYYNNKSDSDMEFMEEDDNIVRETINSSALNEKYNFEMPGFDCIAKNNSSLVFEYPGKFEIRSKYFDRKFESNTHSYKLYVAEITRNGVDFQTFRIFLTVLRFGCNPISFGLQKEQLMDFVELFIDLYCYSESIIILNIFKCLFPLLVLYKYEMFDNEIIRLNQIKFSMKKKTEMYLWLLSIYQIDGIRVSYDNIYSECIDSDFASNFLCKTAYSVDTEPVCLDFMPFNVFIPKEDLNIKYIELERINISSKMLLLIKDCSNLESLILVKCVFPVNFIASVYIYENFKNLKIFRYVGFPLYISQFKNLIFKNLVALDLSCSFFQIYMIVSLFFIFESNTLFKRREERGRWCKKFKPKNKAPLISQEGTTLEEPTNNINKESDLEEETKVVKEVEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW94</accession>
    <name>A0A4Q9LW94_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0711p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000711">
        <property type="protein sequence ID" value="TBU12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW94"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0711p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="193" mass="22249" checksum="5E029464BD4AC718" modified="2019-07-31" version="1">MHLDKRQNEITLIEVGITSKDPLLRVEPAKLEDYNFFATEVDFSKFMGHEIISYVYLKTVLRKNILRGILKNKKYHNYKGIHSLDMRNDEDRVITEEKMTKNIYKDDQSGGTNIHVLLNERIMDSELHKELGFNPLIPSNDVSFSPDVPFIEYENSENLSLVGFENMGNIKSDSSSIHMESQNTGSNNFETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LWJ9</accession>
    <name>A0A4Q9LWJ9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0935p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000935">
        <property type="protein sequence ID" value="TBU12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LWJ9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0935p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="269" mass="32402" checksum="1A517DFE078A1CE8" modified="2019-07-31" version="1">MNVILLFLNNFSHQINHKEKNIENIIDYCENEIKNQFLTRSTEMDSLLEREFLFLGLYKNLFNIYYYKITNFIMVNLPILLKFYIFIIYTNQGTKCVKVSHKILSISYQTIIIKTKQNKYSIEIENLFSFYVVNDKYSKKYILKKFLTYFLRKLFLIQQSIDYMLSITITGRCFIVFTDIPSKNFRKTNVMFISLFLHSLDIDNNYLHILIINKHQINIHYDDTNPQRGIIEFSFSNELYVMITNFSFYRSKIDENFLKNNFTDIISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX32</accession>
    <name>A0A4Q9LX32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0597p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000597">
        <property type="protein sequence ID" value="TBU12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0597p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="60" mass="6410" checksum="39CD36682A133C88" modified="2019-07-31" version="1">MGGVNSMVQGVNNTTKGVTNYLHIKNVLTTLLVNKEVTNKLEGLNNNTVNKAGLNTVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LX33</accession>
    <name>A0A4Q9LX33_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CWI38_0464p0020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000464">
        <property type="protein sequence ID" value="TBU13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LX33"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LX33"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0464p0020"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="245"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="599" mass="70529" checksum="ACA5B49F72D46882" modified="2019-07-31" version="1">MERTSLKKCGFFSFFKKCEFEMCFYDGNKMHSLKLNVGKAYIGYVCKTTQENFKIIFKIDGKLEDSYTFKPIRGRFILKIKNDFFYGNVYVFSTQNSMFHELECKKIRKNPFSKIPFVKTIEICSPVIERFLLYDGRFYFVNKKTLKSFWSEKNEFVAVALPANWEENFTKNGIPYYINHDYRITTWVRPYSFYFVGKIEGKLKRYKILSKKKREYFNLRRSRLNIIARRGFLIQSTAGQIIGAQVADLMKDIHIYFIDEPGEDYGALLREYFYETSFEIAQDYRMQEVENIFDVLPLNTSNSVDNSYIPPTNIEAVKKTYFNYESAEPENPFFENIENKGKNCLDDKSFFKFVGIFLALAIEHQKNIGVNFSLAFYENILQRNFTISHIQDIQFQSSMVWLLENDYDLSSEDVDVNKNSESISPGNNRQIQNNRKDYVTSLISKCFYKSKISSYESIRNGFYYVCVPEFSEIFNCYDLLYILHGNETVTPALIKQNLVFTNCTNSTKEIIYLLKILDKKNEKYLRKFLSFVTGTGTVLFNAIKFGKFTIYIEQENKKISLIRASSCINKLYIGKYDSLEQFEGIIDFCLYNTEGFHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LY65</accession>
    <name>A0A4Q9LY65_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0490p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000490">
        <property type="protein sequence ID" value="TBU13247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LY65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0490p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="356" mass="43025" checksum="D158B5EBAED12654" modified="2019-07-31" version="1">MTNRHQDVIDYTSLEIPFVKVFFKIHLEIIKRLFKQCILKTIEKQITNEELLGGENFINVKIIYRSLFLNFFDIFINRYVISFGGLKFLNDHEFTIYKYFLLNEKFSDPDIIKGLDEIKNRSINEISLITEEKKIKIIQSIINDEKFIKFLIEKVFLVFIGFKNLNKKFLGLSVYDFKKNIECSNSEIEKNQFRKILKKIYTKNNLECLSYYDNAISQTGDKFKRDFYDSLIYAIAENHFNEEFFKMPNRKMFTSIIDCENMHYTFVIRYDSNFVSPKELKPSFIKFSNSYLRRFSDRILYLSLFLKFDDWIVVFIDQIFLNLKEKAFIYFLKQDLSDIKTDRQKQLDEIFRKQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYB5</accession>
    <name>A0A4Q9LYB5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative methionine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CWI38_0320p0010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000320">
        <property type="protein sequence ID" value="TBU14825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYB5"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYB5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0320p0010"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="88"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU14825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="238" mass="27726" checksum="093093AD48856A43" modified="2019-07-31" version="1">MYENDKFSKSRNVGIFGSDLLNDTKGPASIWRFYLIKIRPENKDTNFSVEDFIQTVKSDLINNFGNFCNRSLKFFEEKMKRNIEFNLNEEDKLFISQINDSYSQYLCAMERIELKNGLKIFMEISNAGNKYLQDNINDKERRKTVFSVGVSLVVLLGHICEPFMPSITKKIFKMIEVENTEIFPEKFEVISKCTLGGTKIIPLFEPVDGNDMKTKYKNRPTLNLLTWLKVASIFIDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYN0</accession>
    <name>A0A4Q9LYN0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0417p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000417">
        <property type="protein sequence ID" value="TBU13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYN0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0417p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="492" mass="57361" checksum="6534997DAE64C398" modified="2019-07-31" version="1">MVLLVIKCIKPAAFQSEEEYFNQLVKGINKLGFHEKYADIFANLHDKSEISSVFFKIQGLLFYVPLFIFNKEDADFLNEETSSSVESKDKDSQNLCSKNLMRILTRSDLNIFPGLFKLQKLKEYVFKYEKVTFRDKGTSDLQKNIFLDFIIEYTNKIDEMFSESGCDIVFVEHTIGSESLEINMKSLSGEFENKEYFDIKKVHEKLKDKNIGFAKFIVFLMNKSLVRKIQEQKLENLLFGILKEKFKLIFKKPRLAPLPQLELNKQANEGGDITINVSLNLGSISKKLQKEDFSDMFKEILNENWSGYCQNRGLYELFLTNPIILLKYNLLLYKTEISFFLNFILRKLTSSSSISTNYNVIDFLCQFVELLPQPIFSKIYRILEDTYQNFVTDKSDRVDKEKNKTAVNNLGAMIYYMVSTNEDNTMSILLSKIVAGLFSFVEHGDLKHTEGFSKVFDERFSNIDFYQNLVKNIKSLLIVYSEFSRLDRPEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYQ4</accession>
    <name>A0A4Q9LYQ4_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CWI38_0434p0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="PITK01000434">
        <property type="protein sequence ID" value="TBU13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYQ4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYQ4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0434p0030"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="367" mass="43701" checksum="0C0E5AF54E534E56" modified="2019-07-31" version="1">MDEEQIKEAIINSSLPEEYYTYTFHDGASILHYAALYNNLNLIQKLAGIGFNLDSKGGKYQSTPLFYALYNSNYRVMKYLIINGADINYVNTSGYSLLHTCISYYDTLGFILLMANNVNMNIKDHKKRSVAEYAGQKKRKEIIIALNRFYKKNEKYFPQKSTKYLILFFIVYSIFFKENIFFLFIVSILIKNVVYKTDIMFFINLFYTILFSSQLLERNRWFVVLLIPFIYLKYLLLFTKPKYLMKNDINKCKEIISNILETTELTKKIFCYTCWIKKDKGIKHCSVCNICIVYHDHHCPCLNRCIQNQSDKLFEMYLLVCLILLYFLYSHEIFNDYNFEIRFIIIFIFGILSLRITKMVCNRFTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYR1</accession>
    <name>A0A4Q9LYR1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0283p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000283">
        <property type="protein sequence ID" value="TBU17614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYR1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LYR1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0283p0010"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU17614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="148" mass="17126" checksum="1D6CE8974D5E90F1" modified="2019-07-31" version="1">MHELIRNMNRRFVPKTDILEEKKADIFTDPKEIFDTWAKYFESLLNSMEEDKSDKEECYNNSAKGNIEAIEYPTLEETITVIMSDKLSENIHQSVKIIWRKEKIAEESNVSLLIPLHKQSAQMKCGNNMGKSPLNTGYKILSKIVAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LYZ8</accession>
    <name>A0A4Q9LYZ8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0407p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000407">
        <property type="protein sequence ID" value="TBU13517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LYZ8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0407p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020346858" evidence="1">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="373" mass="45178" checksum="70BA38FD6A0C18BF" modified="2019-07-31" version="1">MIIFLRLIFFIISCKFKIDLQIYLLLLNFSISRNKDVVFYWKETFSDESNTFNLKQEFFVSTHSKKVENKNNFSKRKIHSGGTDIKNKKKITSKIVVSNIEKFPCKFNLLFRKSNNEVNPGINNEINIEISSYDYNEFKILSDFLNDFYISKKNLSIKQFCTFISIFEYLETIIDENFYKIIDLLIRKVYNYLETDRRAFKVDFLRFERIFKVSKKMEDIFFLRMYINFIDFDPNNDSFFENYFIDFLIDEHRLEFLEGNLRVFSVSEGSISIIKQLSKKNELIFELFYCFFHIFNIRKFIFYNSSILFLDVSNILSLFVEFLDEIIFFNQIIKDETILRLMNDKVFKSIKRFHFINTQIQSERKFSLMYLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ02</accession>
    <name>A0A4Q9LZ02_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0512p0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000512">
        <property type="protein sequence ID" value="TBU13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ02"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0512p0060"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="382" mass="44409" checksum="60A59A24E8545184" modified="2019-07-31" version="1" fragment="single">ECTKTLYVEAEWIKCTFNVDVSTSTIDRALRTNYATIFREMGHKDDKNVIFLGEVDKGRNNRDESGYLSLTASRCRNITVVVAMNKYGMIYHKIHDNAVNNEDFKLSIKRFVKIIFVIENARIHHYRGLNDDEEIASYRIKYLPPYSPVLNLIENVFSFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETKKLRKYDLLANELGLIYKCSVEIIPYVMTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVEIISFDRQRGLDWERASMGVIMRAEMHEEPTPPLKEDKREEDGAKNFKPKNNTPLISQGGTTLEEPTNNINKESDLEEETKVVKVVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ20</accession>
    <name>A0A4Q9LZ20_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0245p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000245">
        <property type="protein sequence ID" value="TBU18338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ20"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZ20"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0245p0010"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU18338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="382" mass="45688" checksum="A3FA4FD4F50B87F7" modified="2019-07-31" version="1">MEIFLSKFRNLSGFDIKSIRKINTPNEFKDFVCENLKEASVCFMMSLYIGNGEKSMEIFDALVERKVKNLETVIVLDKNRGKRNSEILNVIKDKNLEDFFYFYDFKKYYMLPAKIRELLYVYHPKVYIFDSNVILTGANLHDTYFSNRIDRYFVVESEKFADYLKNEMFYKILPSLGNYTKLLDNSSFVVEILTKTYILMFDNRQEEEILRKILLEDFQDIFLSTAYLNFPETYFDLFNYKNISIVTAGPECNTFDLNNKNEKYIVQLYSLSAYKTLDRLNNMQYYEFGRKDTTFHFKGLWAFSNGFALTVIGSTNFNLRSNVRDEERNFLIVTKDEKLIQIYKEEIKFMLENSRKVELEELKNRKPSLLSKISYHLFHRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZ73</accession>
    <name>A0A4Q9LZ73_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0237p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000237">
        <property type="protein sequence ID" value="TBU18518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZ73"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0237p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020926722" evidence="1">
        <location>
            <begin position="17"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU18518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="758" mass="90899" checksum="08A2EC1512B2D801" modified="2019-07-31" version="1">MFCMKLLFLIISTISGSRKFILYFHNNEYLSMENNKCQLKLTSFINDGYTYYQHEECEGRNILEIEEIDIFPCKFEGYQDKKSNPFIYLYIDTKVINLEDFLYFIKKIQEDVFQNVNFRIFFTEIKIFDCLKFKNDKNLCKIIRKSLISLIINYKNENYDKDFQYKYHFSSIIVKNILIEFLKIYFFSKKELDTINATEEIKRVSANFNVDFFEKNEEFIKFDSNLLVKVCKKAKSNWEFAKILNCIFKKIKIKKLILGNITEANHYIELPLFIFRFVKELYLFKCEDFKFLFNENTYLIFERIEIIYLIFCKISYFTENIFKDLKYLTKINILCSENIKNTARSEIYFISNDLLMEFYNEMSNLCKMHIFTDIVSNNKKYDLGLLNADSFNISKETPITKFDFNDLKYQIDSYYWITFTIMFITFDLFIFNYKNLGFLSIYIENVSIDGFFFTNTLIVQNIRKIFVVKSRIGPNFLKDILLLPKLKDINFINCKFNFTEIRSKFCQNKNIKLCKIKNSVSNNDQEILNFIKKLNNVEKISLKNNENIKWFDENFVSKKNQFENLFSLIHINSNSTEFLPNICLLKSIRILSIGKKYKEGSLSKIFDENVLLKISELRFKELEIGLKDKLALRNFIGLKLLHIHSCKFKSCLFSDIFDQKKEYFIEKLFLKKLVLRILDILFISKLKYLMNLHIDVMHIEDTNILLFTMSRFLFHNSLNIKILTSSNPKSTLNLLKEEFSTENMSIYFFYNLDEWFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZC4</accession>
    <name>A0A4Q9LZC4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly(U)-binding-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0372p0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000372">
        <property type="protein sequence ID" value="TBU13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZC4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZC4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0372p0030"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="162"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="378" mass="43453" checksum="CEE1F59439B7D90D" modified="2019-07-31" version="1">MGKIILNTEELPENYKRIVSNKKKNIEDLHNLYCQIVDYNTWVLPSTGLLPVLNEDLHAKNFSMHLLNKIYVGNLPYHTTKSDIHKMFEIFGPISSISLSIEGKSKLYSKKFGFVEFENPNAAVLAIKEMNTYEVDGKALKVGRPANFPSFIPDDIKNPDKRIIYVSNIHEFIDQNQLLSIFECVGKVEQLNLMLNKNRSCHMGIAFIKYQNIDSADLSVSLYNNLSVGGKILKVCKTVIKQKMPSKEIFQDTITKLPNEVIKIIADLNSKLNDKTENECLVLKNMIMVDDLDEDFINEIKLELKKYGEILELKIVVFQPTLLQYTILKEGDKKDVEVYCLFRNSESVNHCYRIMDGRYFGGRRIYAESIPKSEFNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZD9</accession>
    <name>A0A4Q9LZD9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0367p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000367">
        <property type="protein sequence ID" value="TBU13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZD9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0367p0020"/>
    <dbReference type="OrthoDB" id="2191898at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="257" mass="30321" checksum="80A1B5DF04C02798" modified="2019-07-31" version="1">MGELLLITNIEDDIIFKKEFDIMNDKEYCSLFMLGYSSLDIIEEIRFSTVKTFFKSLDTQSKWDVSVYFLPSGFKLIYINEDSEEKRVYDFMSKVHILLRKKMLEIDVQKPEVFNCEILLSADISVSINQYGNGNNTASPFYRLAKFTDVKRPNNKIQCMLVVKSVWDFGEKFEQYLHATILMVENNKKNSTFTDNRGFKKQLANFYSEIEKRRLLSKLYNEENISGDIKPRDKFFLYPDRNVFLEEEKAFSTQPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS7</accession>
    <name>A0A4Q9LZS7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0430p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000430">
        <property type="protein sequence ID" value="TBU13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZS7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0430p0020"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="73" mass="8444" checksum="B7D6975D8310BE6A" modified="2019-07-31" version="1">MQIKIKTLEGREIEIETDHNETVKKIEDYELIPPLQQRLIYYGKIMSDDSKKLVEYNVNNGCVVHLVLALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZW4</accession>
    <name>A0A4Q9LZW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0473p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000473">
        <property type="protein sequence ID" value="TBU13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0473p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="284" mass="34588" checksum="92BCBF74EA88AF4D" modified="2019-07-31" version="1">MGFKTNDNHIENLIMDFYNEKLLEFNFLQISKYEYINILIFKNIKRLVLEEIKIIEKNENVRFTYRNNSIMILEVIYPEISSKSIIYDYIDMLDELKNLRLQFENKLAKNYILSQFKNRNKKMLINFLFSDHSISKYDILELSFLTEVDCKFNQIESLTFKYCIFSTPDKESIRCKNLEYIKFHRCKFDNINFSNLFCKDIRYKIKKFYMNESQLTDKDLIWLCSLRCLVYMSFFDSIIPYNALLKFKKSDFANPTNLKLNLFQYKNRSKYKNHIYEEFGLIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZY2</accession>
    <name>A0A4Q9LZY2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOZ/SAS-like histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0308p0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000308">
        <property type="protein sequence ID" value="TBU15715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZY2"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZY2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0308p0050"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="3">
        <location>
            <begin position="187"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU15715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="556" mass="65031" checksum="614939BFCC9E5F01" modified="2019-07-31" version="1">MFYVLLNNTLITTTTVINTYYFTVFCLLLANTPLTPSFITTPPLFTHNIHYYYPFKNTKISISSMRLKRHKFYKKQRRNTKKSNNEKQPLLIQTPNHQTYSLLNTEEILKKEFFPINFYTTKYKNFYSKNKKYIFNFKKNVENKNLESKKLFAKTNLETKNVEFNKYSLKKNIENKYINTTLSTPHITPNTSTTIFINNSYLNTKYFSPFTTWTNCIYICSKCMLNYSDEHAYQRHKNRCVKEVGKCIYKENYIKIYEIYGNKDKQYCRDLCLLGKAFLENKTLYYDVEPFVFYVLFFKENFVGYFSKEKIFVNENICNSKIGKSETSESKIGKFKIGKPNSNETDSNKSKISASDSNETYSNETDSNKIHSNKTDSNETDSNKSKISELDSNETDSNETDSDKLDSNKDTQRLDFNKTSSMNFDTKVLTSGKYNLSCIVVLPTFQGQGYGFMLVDLSYKLCVQEGTVGTPEKPLSEAGNACYKRYWKYIVYKNIEMCEDLVIEELAFRLGMTVDDVVYALEMLEILKKNDDGYFLEGKEIEVQKVRILNQEGFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M029</accession>
    <name>A0A4Q9M029_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0162p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000162">
        <property type="protein sequence ID" value="TBU19964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M029"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0162p0030"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="202" mass="23682" checksum="B3C28574435F39B6" modified="2019-07-31" version="1">MDLKRHILNPIKYEIKQFKELKFRKLNEITIEVLSREGGGATKIEGVDSKTDSRVYSKEVLYQTDKVDNKEIKDKIYHKELDKTDKNINNPSDNLLDIIYNGKILSITNMGTEWKEVYKIKLNKTIDFIPGDSVGLYCYNPEHVIKVLLSYLNYNQEASSYNDIYNTFYKIERKGCYSYEYSGNLYGFLRKIDVLSLPKNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M058</accession>
    <name>A0A4Q9M058_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_2162p0010</name>
        <name evidence="2" type="ORF">CWI38_0158p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01002162">
        <property type="protein sequence ID" value="TBT97621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000158">
        <property type="protein sequence ID" value="TBU19990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M058"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_2162p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0158p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBT97621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="117" mass="14015" checksum="7E7C3353A177139F" modified="2019-07-31" version="1">MSYDFKSLDYENKKYLTFKEYMCLSLLNKKYPLSSSEMPQKIYKNDIKYKKYSNILQIFNFLKIDKSINLPIITPFSLINIRNKLFIEISDKEIFEMVNLLSSTEEITFDLFSRTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M069</accession>
    <name>A0A4Q9M069_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory subunit B of Ser/Thr protein phosphatase 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0252p0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000252">
        <property type="protein sequence ID" value="TBU18149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M069"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M069"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0252p0020"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU18149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="398" mass="45640" checksum="AAAD353D00D00704" modified="2019-07-31" version="1">MWTNTDIVQIANLSSTTYNNTELITFVTFKNQKLYVGRADGKFECYNDPQTKHYELQSHVSEFDYLESSDIQEKIVCAEIIQDGGISDILFLSNEKSIKVWNCKLDIPTAKIISKEVNIQPVTNNKNREAKNVIPRKSKLMYKSGSYKFDMLKEQRNIHLYTINSLHSSLNSEYLLSSDYLKINLWCTRNMDKAFCIIDIKPTRYEELAYVITSSRFKCDDDMVFGYSTSKGEINIQDLRIKSSSGKVMTMGKRTNSSVFDDLMKSISDFRFCDDHTIVARDLSSLTLFDTRNTNKELKSVKVFHSDGNLIDDIFESQTAYEKFLVEVSQNKIVTGNFGNKIFILDKVSFATEEISVGEISDLEIVDFSTRIRNIAVENNNIVAALGDQCYFYKNVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M072</accession>
    <name>A0A4Q9M072_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0150p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000150">
        <property type="protein sequence ID" value="TBU20014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M072"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0150p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="51" mass="6191" checksum="B2219BE6499DE8C8" modified="2019-07-31" version="1">MYTLKNDLNIINIEEVLQDPKNLFQSQKNYERVKKTIHKNKRLKAKPKQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M0U4</accession>
    <name>A0A4Q9M0U4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0098p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000098">
        <property type="protein sequence ID" value="TBU20274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M0U4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0098p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="204" mass="24128" checksum="32DF49DE5EC8798F" modified="2019-07-31" version="1">MLEGVNNNSMLEGVSYMMIDCVNDSLLIISNVFFIISFNYTYRSLQKIFENVIVNTNEILKNILEIILENILENILENVFRKELYEQLLLKVSKNILDNLLIIISMKILKKTLFEIFESKILKTLSEIYNLNTIRNNYDFIRDIYMENIKEDSIGNIKIENIQDSIKYILAKYLKECPSECLHEYTGMVFHFKQQSKYFSIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1B9</accession>
    <name>A0A4Q9M1B9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0060p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000060">
        <property type="protein sequence ID" value="TBU20504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1B9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0060p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="216" mass="24553" checksum="D64348C5A630BF00" modified="2019-07-31" version="1">MINNKSDNTCKSGTYNTNYLLFIDDANEFLGITGLERNKEKSVIKYTRGKGNDTLLEGVGVYKYSRIIEHIRSIPTPTGNIFDIHCIEIHRLEPADFCKLDDSNNIHLHPACKEFTVIELKSKNMLLKLMDCLETSKEISTRRLATLKRKILLGPNTEESWKSASMCNDEDGVYEIKTKNIPRLISKGVTTLDGLIINISEESNLEEEKRVVQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1G6</accession>
    <name>A0A4Q9M1G6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0052p0060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000052">
        <property type="protein sequence ID" value="TBU20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1G6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0052p0060"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="637" mass="74287" checksum="5C6DD3938D75865F" modified="2019-07-31" version="1">MTALDPISNRHLNQVYSNLLKNGLMGFEGNKILEDPNNYKKKYLKSKKHAFMYFFSVLNDSIDACLIRKHSMVYIFKRTAHFIDQCFKDVDNFSFLTMKLTMHSLKIICNTFSDFEWSIFNWLLSITNISGFYFDELETVYYGIETLSLYNPNTKDYVKKFEGEHNTVDFLFFQSLSSSNFERIIYLRFDNTCFSLDAIASFFRNKKLSHFELSYCTCDETIQISEILIKNSQLNTLKLRGMVLCAKDIDLILRSKIKYLHLLECTVETCASEIKEYTFKPGYRILKTLTSLDISFSKLPVSFVGILLNADFIGNINISSFEFLEDEHSPISVFSLRRKLNFLKIVNSLQNEYLLKFFMEIESVHTLVLSKISNIENLGLLFLLPGFYDFVLALDLSYNKFSAQSFNLLSKFNRVSSLNLENSLPLNIDEINDLPLFDTVEDLNLAKNEFRAFNNNFISRFQRIAKLNLSNSKFRPGALINILNDRILNCLLYLDLSGIGLENDDFERVCEFKTLKFLAIDLKIDFTQNTYLEFLMFSPFKLHLNILMLEVKKIRILDFLNLAVEFPNLKNFRLLCEELLMTPEDCQNSYFTTYNTTGFCCIELLHTFPIPEYAIAFLQTIPAIYSISFFYHPQVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M1N8</accession>
    <name>A0A4Q9M1N8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="3">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0047p0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="3"/>
    <dbReference type="EMBL" id="PITK01000047">
        <property type="protein sequence ID" value="TBU20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M1N8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M1N8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0047p0020"/>
    <dbReference type="OrthoDB" id="2195148at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF60">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="404" mass="48085" checksum="3A1072FF6C7AC92D" modified="2019-07-31" version="1">MFIIAGCTGIGKTEIANLLSKKYSLLLISCDSIQIYKDMNIGSNKGTSNTNHSLIDISCWKERFNLYKFEQKLLEILIENKDNKIPCIVGGTGLYLINIQSEYKIEYVNNKRYTNTMESKDISNRYINTMDSNDISNRYINTMESNDINNNRSINTMESNDISKSKYIDNKNNEYINDKESKDISNNNYISNEFNYLGNKIIKCNFKFFLTTKREILYRKVDKRCEEMILNGFLYEIITLYFEGLNDNYISGRSIGYRDGLDFINKLYQRIKEHSFDKSEIFQDLGYFVENFKEFLEIFKRKTRNYIARQECWYKNRGYIWIDCSKYNAYDIISKCIEYLTDKNLNFNEIDCFLKDIHMNSIEVNKNSFKLLKRYNSNNECFNNNFNFDKFIKDLIEKLINFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M258</accession>
    <name>A0A4Q9M258_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CWI38_0018p0060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M258"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M258"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0060"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="262" mass="30542" checksum="976CC2D4E647EE1A" modified="2019-07-31" version="1">MSSSINYRFRSMKNFAKINFEGNSLPLWELRSEIITQKKITSKDFDLIFYDAETNEEINDEYQPIYRNSQIIIERIPAWMSKNRNITYVVKSEDKQKSIRDTSSVKKYFKPPPPNYVCFRCGQKGHFIQHCPTNQDKNYDILRIRKPTGIPKAFLVPVKDEEIPPTAAMLVTPEAGYVKAQPQTHEWQKISSKTSEYDISNDLKCSKCKFILNNPVKTDCNHKYCDGCIFIGDRCTVCDNIVSNLSDDLKTKFKIEKFFEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M273</accession>
    <name>A0A4Q9M273_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_0234p0010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PITK01000234">
        <property type="protein sequence ID" value="TBU18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M273"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M273"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0234p0010"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="230" mass="27674" checksum="7804ADE1B170187C" modified="2019-07-31" version="1">MKTVQRVIVAFEYILITTTVCYIFLSLYDTLKAKGYITKAILLYFLLVSSYYYLSILVKKDVHILPNTEIKGLCRKCNKLRCTRTFHCDTCNLCFYKRDHHCPWLAKCISSSNYREYYFFILFTVIYLSLKVLCGCLYVNQIVFLNNYLLTILSFFFIWTNFLLFIDKTSIEYYKSRKRLNVSRYFWQEIDFGVCFDRLYEVLFDREIMNVLIMFFPFLQKRTSIIEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2D8</accession>
    <name>A0A4Q9M2D8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0188p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000188">
        <property type="protein sequence ID" value="TBU19842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2D8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0188p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="427" mass="50457" checksum="D3E38E6FA83F2A2D" modified="2019-07-31" version="1">MYSNNQAIIFIPSVPVSDSSAFRSADTRKNLKAPAIPIRKLVIVLHSMPDSSQSVILAVQKRFERMPRHGWPATLRKIMQDENKERRSYSKYYLLKTVTDATRTLRHLCKTKPRSARKENIEILLMKVYRQKKLSSFQTKSIGKIMRELHFDLSKTNDLSEALVKKNMSLNVYEKKITMYESMRSRKENLMFDYTETNKIAGVKKFMNNIGWEINKDMSAVTDLCCCYKYTGIIEDSRVISISHVSKEQFISSLRCKIRLMNLRKEPEKSVRPRDTAVFCYIHDRNKTINHLAARFEKMLGHENTRRNDEYAEIRVDTRIRTDVKIRCNRPDIFLYDKKKYRIPFIELRKYYLLAKVLGLIYKCIIGIITYVITLDDIITKYNNTYIKRLQIPRNVVAYIHFIVLKKRVETIFYDRRRRLGAKARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2E1</accession>
    <name>A0A4Q9M2E1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0009p0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000009">
        <property type="protein sequence ID" value="TBU20920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2E1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0009p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="93" mass="11118" checksum="90AB36D5BACD37B1" modified="2019-07-31" version="1">MLFWLGEKIRYHSFNMTCYLYDLDLFYMCSIEIISYLHLKRLRIPQNRAIGVVMKAERHEELTHPLKQASNDEDDEPTNNLNEEPDLEEETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2G1</accession>
    <name>A0A4Q9M2G1_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI38_0007p0010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000007">
        <property type="protein sequence ID" value="TBU20950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2G1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M2G1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0007p0010"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="7">
        <location>
            <begin position="239"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="307" mass="36803" checksum="FE230632763CE680" modified="2019-07-31" version="1">MKSRIYLENWVMSLLDLKEKKTVEKFGCGVEYALVLSKIYSDFPLKQINTAAIRSDEFLCNLRVVKTFLDSKGVVVYMPIEKMVNCKTMDNLEFTQWLYKHFNENSVLKKENKTIENEISPQKDQFKISPKTKNSPNNFNEIKNQNNIQTDKNLNTNNFNEIKKEDFSHKNVNQIQNETQKSNNFINNENIYEKMLNEKEEEIKNYYENILTEKMEEIKNYYEQILNETGLENLMLKAELKNKMDTLIEEKEKNIKMEELIIAFEKERDFYFKKLYKIEEIFLNWDSNNVNIKELFHKALYDENNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L7</accession>
    <name>A0A4Q9M2L7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0205p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000205">
        <property type="protein sequence ID" value="TBU19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0205p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="59" mass="7267" checksum="76F1D96E3DE10FAA" modified="2019-07-31" version="1">MNWIRKKKKDNKLYLETKENALSVIESTLLSKEQIKHLKSKENIWKYMECKENKEKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2N6</accession>
    <name>A0A4Q9M2N6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0167p0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000167">
        <property type="protein sequence ID" value="TBU19942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2N6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0167p0030"/>
    <dbReference type="OrthoDB" id="7789470at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="104722" checksum="144D23C5DF271A37" modified="2019-07-31" version="1">MEKNKDDICCKFCRNKLVYRKATNGCRIYLFSIFNIFQIYLLHFILLNKCACLQIEISFSNEAENFEVNCNEAVDNLNNLCENCASDRIATERIPQSNVQDFSDNTPALAALLDRNDHIVDPGTIPIITGISSKKRKQDLFLPEFDKISNIQYSSLNQRQTNEKIVSQGEELQPLDLRTNKKQKTYDLIEFENNEWILKTPTSIIFEYSDKFCIQSKYFNKYKHTELNYVRYNITDLTKSKVDIATFEIFLFVLRFGCHKKCIDIKICSFITFLRLFCDLLCHAESDVIRNLYKSLLPSFFIYKNDISVNIHIETPENIFLVQKSLFLPFLNTFFSNVEVKFDQNTKELSLLKRESSLHLYSFDARNIDEIIIRTTSEVINILETESNINLKLFFWLISLFKIIGIKISNDNIYYSESKERDRICKYENSALAFPSPNLKLLYSHILESIISHNNNEIKFLELERVNISEGFLNFIKILCKIESLILYTCKLPAYSNFLCHLNFCFPKLKTLKVNTLILTAAFFKSLRNLKIEYLDLSWSTFDGKYSRDLELYDGIYTLCDLKLDNSRLGYNVINFLVKSNALEFLSMKNVDFSRLNRTKYFILLQRNYSSLDISGCFLNKNFMNFYSSNFKATSLSLRDLNSENLQKMLDLNSLHISTKILDLSKSCLDFKAIACLRKFKVLETLKLCSLPYVEFKYLNQEYSFEKNLYVIDLSDSKLIQENMVFLNRFEFLKELRLSRCNLKEGLIRYILPKSLFSSLEKLKISENSLDIYDFYLLSQIRNLKYLSITLENSIFRNSLKENDLMCFTKLNTLILTKTVITYEIFQFINQQYLLTHLHFKDCTFEIDFSSISITSSLKHLNHIVLINSKISADNKRRLEDLIIYNITVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2X3</accession>
    <name>A0A4Q9M2X3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0144p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000144">
        <property type="protein sequence ID" value="TBU20042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2X3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0144p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="38312" checksum="385A86F50AA5FFA4" modified="2019-07-31" version="1" fragment="single">MGKPKDFDIKKLKISENIIEEEFDSEISDELLSYSEIEKNIKNKRQKKHKNVNKTETIIPPVSEDLKNVDWSKIALDLDKMKSKATWKKDKKELKFIPINLENDKIEKMKIELIRNPDNNFLRIQLSKLLDSYNSEKILLDGIANSKTKCDKLWIELLNSFYTKERALEALKNIDTNKEEIYIKLYENENDISYIKEGLKYNQKSVILWNLLIEYQESITSKFGLLSYAIEMTRNDFFIDKLVILYEKYLKNEEFNESKNFHESKNFDQIENVLEKNDQLFNFSKIYNFLKENKHFNENFSIFTLNNAKDKEMFRNVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3F8</accession>
    <name>A0A4Q9M3F8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CWI38_0106p0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000106">
        <property type="protein sequence ID" value="TBU20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3F8"/>
    <dbReference type="STRING" id="1176355.A0A4Q9M3F8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0106p0020"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU20242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24641" checksum="B5A17724E8655B79" modified="2019-07-31" version="1">MKIIAITGSIATGKTSVANILMDKGYVVINADKISNKILYKNLEKVYQIFGDSVKNDDNTLNKVELRKVVFNNKEKRKELEKLIHPKVYAEIIFRLLYYAFMGKSIIFMEIPLFFECKLNKYFDSIVVYCDYETQRNRLIERDGNLLIDQKIKSQMDIKYKICNATYTIDNSNLIESTKIQLDKINFKGVNIYFYIIYILVLLMVYSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3Y5</accession>
    <name>A0A4Q9M3Y5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0070p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000070">
        <property type="protein sequence ID" value="TBU20442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3Y5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0070p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="589" mass="69420" checksum="7082C971E4899781" modified="2019-07-31" version="1">MNVVFNILNDTKETICELMYKEFSTKCFNKIKRDVLPERNDSIYIEKMAIGNFKCPYDKYTIKNIERIGLEFGVFERFKDISENIEIFLCKHIMKVDFLAFYEHLLSYNFPVYRIIIEKFYTIMYFLEYLRVKHDNKLRNVIKIIWYSLVKSEEINNFDIEKVSFHFSKQDYFSHKMFKKISQEYFKVIKFEMNTFDSFFSKKEINYISNKGKCLYTIEGKHVLTIINYEFDLFFSKKVVVHPKSKSLFLIFLNTLDIRYLPFCDICIISSKAIDEIVFVKCYISDETIISLNNINLNFVNLEKIVFIECVIETSLVFSDPLGEINELVFYVDNAAKNNYSVHEIKVIKNLDIVENIVEILKCTYHKSTPEELISQNSNILDKNKDFYLRLLNDEKSKSDLFKSKDTIIDKNTKCIKIASSTITSIFLNDILSVIGLETLGINYSDILFENDICVKNKPIKYFDFWLKTRQASGYFIELINMMIGLEEASLTWINSLKLSRSLIQCFYITELGVSEVSKMIYSFNFKSANNDISDFNCHSDSLKLLFENYDLSSITKGTLSQFSIDKSNLKAFSNLHNLKELYFFRINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M404</accession>
    <name>A0A4Q9M404_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI37_0428p0030</name>
        <name evidence="3" type="ORF">CWI38_0028p0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FI-OER-3-3</strain>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000428">
        <property type="protein sequence ID" value="TBU02707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M404"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0428p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU02707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="320" mass="35959" checksum="71AFA45E916A7EF9" modified="2019-07-31" version="1">MDEDIEDDIDEDIEEDIDDEGIEEDIEEDIDEDIEEDIDDEGIGEDIDDDIEEDIDDDIEEDIDDDIEDEEIEDDIEEDIDDEGIDDDIDDEGIEEDIDDEGIEEDIDEDIEDEEIEDDIDEDIEDKGFEDDMADDIDEDIEDEEADDEIELPMDDDFRSESEAESVFLEADWALEEPLFSVVFFPNPKKAPIPEGSFVVWSVVSDFDFSADFWDASSDFDLSFASFEADFSGSAAFFDSDFLAASSDFDFSFASFEADFSGSAAFFDSDFLAASSDFDLLAASFDADFSGSAAFFDSDFAFSFSSFDADFCVSSAFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M409</accession>
    <name>A0A4Q9M409_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_1034p0010</name>
        <name evidence="2" type="ORF">CWI38_0099p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01001034">
        <property type="protein sequence ID" value="TBU00352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000099">
        <property type="protein sequence ID" value="TBU20266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M409"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_1034p0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0099p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU00352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="90" mass="10767" checksum="57F8396274E7E85F" modified="2019-07-31" version="1">MLTEKLEEIILTEKFIKERLAVLQAGKLDYENLEEVENKIKELKCSINKFKKINRNIIKKISKMENRISIKDENIEIRKLYISCLDKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M416</accession>
    <name>A0A4Q9M416_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0085p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000085">
        <property type="protein sequence ID" value="TBU20351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M416"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0085p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="162" mass="19460" checksum="D3136F17544773FF" modified="2019-07-31" version="1">MADTVVAEYSFEKNQYKYNSFTLSFLRNDICRTFEIKDMNFFIFKKKLNLILKQASSRFNFPLRDLEILNSYGFMKKNSDLEIINIGDILDDRFKDHAKYRIDRFTSLLYTTDIQDINKALMVSYICNICPCLIDLINIDYFDSKYEVYYVKWIHNYKNTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Q0</accession>
    <name>A0A4Q9M4Q0_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0028p0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000028">
        <property type="protein sequence ID" value="TBU20732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Q0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0028p0040"/>
    <dbReference type="OrthoDB" id="2187573at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020895491" evidence="2">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU20732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="401" mass="46093" checksum="0167E1F81BDD73A5" modified="2019-07-31" version="1">MNFLFYFAIVLSSITEKKAEKVKYEGISDKKYAEIKGGIIHNTGILLRASADKGGSVHFNERNEYDEWSFEVHFKDMDLSFPSNGGLYVWYTDDSVEEGNFNGGSGKFVGLMAGIEFLGKSVDLVLGHNKGDEDFSEVEDFVILRDSPNPERFRNVKELSLKVISTKKNFKIEIYDLSNNSKKIIYDNLRFTETSSLGERGRNKYFTITTRYDKVPMEKGFEIISAVLYNRAEADDYDPFQTKAEVPSDEPRMPDSIYHPNKEIKFLIANLEHHMKYIKMVMGNPTGNTLMQFGLENKKEISGQNVKLEQMYSSLKDIKNSLERNSVASINSKINDIDYRLSTLHKEFADFRYFLKKFEKKHGRRSNVMSICVVGVMCAGIVLVIIKEILRRKTVNEKYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Q1</accession>
    <name>A0A4Q9M4Q1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0053p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000053">
        <property type="protein sequence ID" value="TBU20546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Q1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0053p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="85" mass="9719" checksum="5A92547E0A0283B6" modified="2019-07-31" version="1">MSSYVEKTSAVSSLTSENSTHSCFVYKKTPYGSFKISNNIIINYFNRPPVFKSKNFKVSRTFLLICLEIQDTTIIDTLFKSITSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4R6</accession>
    <name>A0A4Q9M4R6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0026p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000026">
        <property type="protein sequence ID" value="TBU20752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4R6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0026p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="320" mass="38119" checksum="3CFFCC1B01D453F6" modified="2019-07-31" version="1">MGREIIFRKFNVKKYWNNDDLSAFFEFAYSQDFITLTIFDIKKFPLNFKDDGINDKSENIDDLLNVFNIEIFAIKNFELFLSTYYLPQNNVLIKDFLNFIYLFEIIGVCFDDRFAKMIEILTASLLISENFDSFDFKEKIFNLFPTDLLSQVCSLFVFKKLIDFLFTDFKFNDSERFYCSDYLYLPIFIRERFKNRNCNSLHLNEFSLPISFNEAKYTRIQKNIISLILYILNYKVVEIQLSLFFLVSLSVGSIEDVIFNHYEIENSFIQFLNECSFFKKVKNLYILNTNISDDIIPNPVNLVNLETLTIYEHEILKSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M5L6</accession>
    <name>A0A4Q9M5L6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0017p0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000017">
        <property type="protein sequence ID" value="TBU20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M5L6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0017p0070"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="696" mass="81020" checksum="272E372C568B3ADA" modified="2019-07-31" version="1">MLFFGQPDFNNQLSESIIVENEASTIVHAIYIDPDIVLVEENAAYTQWSLEIGSYVHEEFTETLTTVIADDLASDRKILFDRCSRQNANDSRNYINSSPTFDSQEEYSPNPTCDNKSSYKQSGKGLVEKDAAEFSRFNSSYTNKKNISDYRMEKSLEKKYKRRKSYSSFSGNKRQYPPGIYTGRRVKDETSTRKIHRNRNTFKRKYDPVIEQNLTAKDCKKIKTLIRAEEIGTQDTPRTKSNLDIEDNPEAFTDIKLSELPIYQLELIGEKLKNELDEVKKECLTKAINTKNKSHVMFIDSSELEVGRRDIITFIKADFDINAIYVLEDTKFFLELIKYVDQNEKLFWKNSGFSELSEIKNLKDKLLDRIGKFNFCKHDSPFLAYFPGLIHMKLFVENLIIEDINLVKNACLWILLLKYVESLTFVSIKDPNASGKCHKTYFNSKYKGYKIYAGNEYILCKMKELYETFDAIVRHVFLKAKISTKFSVMFDFIRINLQLSHTDIYVSDRKRIVFSKVLTDCILRTKPEVISSFILQLKNQKCSNLNLEFFFNSTNKFLKAIFSKSIELNDVDIKDIKAFYVEVALAYIDFFKKEAACLDFSNEKYPKCIQKMVKIVKEVFETDQVQKQIKKLTDLTALMSVTEDLCFLSNYIIKSGLNNQAYSEIYQSHTFKACKFRLSKNSILFATIKQQKINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JVT6</accession>
    <name>A0A4V2JVT6_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF866 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI37_0023p0050</name>
        <name evidence="2" type="ORF">CWI38_0084p0020</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FI-OER-3-3</strain>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000023">
        <property type="protein sequence ID" value="TBU05332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000084">
        <property type="protein sequence ID" value="TBU20358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JVT6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JVT6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0023p0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0084p0020"/>
    <dbReference type="OrthoDB" id="2189688at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU05332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="169" mass="19682" checksum="7C90F24B8C7F1E72" modified="2019-07-31" version="1">MKYDLFVAGTFQGVSNIMVEQTFSLEIKCSYCHKTHKNHVIVTDESKQYNNKDEPVNLKVKCAECGKQMTITVHIPINSTKYKYTNKDIMNEYEVDLYLNPKKDNSFHVSTLDCRGCFIEKIDDLKCSVLSEWDIFFKDVEIFDGYVRLEDLKGRVTTIEDFSVNFIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JWG7</accession>
    <name>A0A4V2JWG7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2387p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002387">
        <property type="protein sequence ID" value="TBU07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JWG7"/>
    <dbReference type="STRING" id="1176355.A0A4V2JWG7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2387p0010"/>
    <dbReference type="OrthoDB" id="2195822at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="210" mass="24418" checksum="1FFA663CBB40C6EC" modified="2019-07-31" version="1">MSDESIKSKNESDSNANEMSSDANSEQSSENNTYDDYTKGYNEKDSNRQKKPKQKSPKPFPNKLSSTLPKKKWDMDYVNKNLDDAHHLVAKTNPELDISTKRYYPECFYGYDNMTMFLNDVMPSLRKMKKNDSEDGEIGGDTSSDDSIIITHRRKRLRIESESSISSSSSEARKHQLLRIFFRLMCFPKQQIIFSRLLDLDVRLPPMLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX52</accession>
    <name>A0A4V2JX52_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1750p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001750">
        <property type="protein sequence ID" value="TBU10452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX52"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1750p0010"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="165" mass="20186" checksum="D58AFBEFD78541EC" modified="2019-07-31" version="1" fragment="single">MKLYNINECLENNQENIQNRRKMYWKTKEALRRADRTKIDLKNIEMIELLLNIEKNVYFKEERQLETYPEFMQRCKSNFLKDFICCNNIFTDFDTYVMHVQKYHQTEIEAENQSSINNYENFQLSNYDFSNFQIPELNLLNEKPYFGIKKPYPCKVKGCYKSYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX60</accession>
    <name>A0A4V2JX60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1680p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001680">
        <property type="protein sequence ID" value="TBU10562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1680p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="254" mass="29894" checksum="C0F21939BE631F29" modified="2019-07-31" version="1">MQEWKCFDDNQLDEEIMKATKINFLISNRESFKELCVILSNAKYEFFFGFFTTLKIDFVGKAGGYLEFFVKSTSENLKISPEFLEEINNTVEILNKNIYSESGDHQHKDILEYISKTIITKVLSDSIQFNKICEFSNNMGTFQNETEDLNFTRILIEIFYEENEVNYIKTLYEWLMKKKEYHKYISAVLCLKVFCFKGKFSDKNIISRILIEFLFLADVLKRELHKTGNVAEINKCREVYVNVGYLGDSKVLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX65</accession>
    <name>A0A4V2JX65_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1654p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001654">
        <property type="protein sequence ID" value="TBU10602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX65"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1654p0010"/>
    <dbReference type="OrthoDB" id="6493019at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31837" checksum="130EAEA7F83F8B7A" modified="2019-07-31" version="1" fragment="single">SDSSRWLKRGNIRPRNEAVFCYIQDRNIFWGADGVCQHCGKSGKTVDHLATRCEKMLGHDYTRRHNEVVRCLHLLLLNRYKFKSSKRIRSHSVQEILDNEYAEIRVDTRIKTDVKIRNNRPDIFILDKKKNKITLIEVGITSQDSLQIVETEKLRKYDLLANDFETNSYVMTWEGIVTKYYKSYLKRLEIPMNVEVYIQSISGLNAEESWKRASIDLIMRAEMHEEPTLFFKEAKREEDGGTTLEEPTNNINEESDLEEETIVVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX84</accession>
    <name>A0A4V2JX84_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1541p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001541">
        <property type="protein sequence ID" value="TBU10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX84"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1541p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="97" mass="10877" checksum="CDE4AA2084A6597E" modified="2019-07-31" version="1">MNVEAYIQSIVLKKTVETISFSGLNAEESWERASMGVIMRSEMHEEPIPPLKESKTEEDAPLISQGGTTLEEPTNNINKESDLEEETKVVKVVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX92</accession>
    <name>A0A4V2JX92_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1475p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001475">
        <property type="protein sequence ID" value="TBU10922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX92"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1475p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="396" mass="46950" checksum="7C64921FDD357DC0" modified="2019-07-31" version="1">MLDEIKPKEITEKLLNTNQEKIEHLRELLENVFIVFAGSFIQLDENLTDFSVYNSIKNKECLISEIKNNEFFKIINKIYSKNTWKLPESYTNRILQTPEKSKKCLFHELCRLMYVFTRKIFTFIFDNKELRLPDVMRNRSNYIFPDDCEDFPDDGAERKDILKETFGETPEISPFCDDLKPFLIKTNISFYIYKVEDSIFNDIITKFFEEKKISKKKFFKKLEESPLAYLYNEIENRKLHSKLYSAKNNELVSVCDLSRWLKKGSDRNVFWVADVMCQHFSKSGKTVYHLATRCEKMLDHNYIRQQNEVVQENLDNEKYDLLANELGLIYKFGVEIIPYVVTWNGIGTKYHKKYVKRLQIPINIETYGQSIVLKKTERASLSVILGNEMHKQLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC3</accession>
    <name>A0A4V2JXC3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1295p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001295">
        <property type="protein sequence ID" value="TBU11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1295p0010"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="116" mass="13355" checksum="076167491AF531F0" modified="2019-07-31" version="1">MVGIERIGDMIYYSKGVNKIRKMVGIERIGDIMYSCKGVNKIRKMVGIERIGDMIYYSKGVNKIRKMVGIERIGDIMYSCKGVNKIRKMVGIERIGDMIYYSKGVNKIRKCFINTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXC8</accession>
    <name>A0A4V2JXC8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1300p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001300">
        <property type="protein sequence ID" value="TBU11252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXC8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1300p0010"/>
    <dbReference type="OrthoDB" id="2195190at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="160" mass="18582" checksum="889590BBF6CBB81F" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEETKVVKEVEENMKKCILNENIKEVEETLNYNLKKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXQ3</accession>
    <name>A0A4V2JXQ3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0663p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000663">
        <property type="protein sequence ID" value="TBU12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXQ3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0663p0020"/>
    <dbReference type="OrthoDB" id="2195201at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="337" mass="39697" checksum="5CA96C261ABEFE3F" modified="2019-07-31" version="1">MEFESSDNFSAEEVNAQKEPNLNINTEAFDVYKLYLDRVVSLPFIKTNQDTLKSDQKQPNIFFKNCKYINYEVLQNDYFENARRCYSTFDKEFYPKYFGKNMFEKYHFYKICVTYMENRIKKLVSYVKSEPFLQFENFNAFLKKFSPHFNAENVTSCGPSFIPISVNYVGGRSQSDEKIFLFDIDDVFEKIVERILDGNHTKLSTVSSHIKFKQELKEVLKKICFANFIDRSAQYIYKEINLLDFFNSVIHIKSINRYTAILKPEESAYKSVEEFLGTSPSNNYFFDNKSKNIDMARERCWNVFEVENSLVNILKEALKSLKTEDSSSVSNRNSTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY13</accession>
    <name>A0A4V2JY13_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0294p0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000294">
        <property type="protein sequence ID" value="TBU16698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY13"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0294p0020"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU16698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="297" mass="35783" checksum="B6E662BA99D53AAE" modified="2019-07-31" version="1">MLLQEKHIYLKDKLLSNVIFKFKFKYLNSFTNYSMYIRLICFMSINMLILLFFTVFHKKTDILETNINNSSKRFQSYYEDINLGNIELFFDFLFWFSVVFKMLIFLCENISNDIRSYKHLAYIILWKLTRVSCIFFGTFLLIKVMFYSTIYWYSKYNENDEVYKDNYIEIYHKFSCYYKPWIVIMSCYTTFFDCGVVVYDFCKKLMMVYKGNELPEIGCFTILVYCLMIICGLVVIFLLTVYIWSYYMLLAKSKPLIDINIPVLRVVTALISILSSIFLLFYEAEYLKNLETIYNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY34</accession>
    <name>A0A4V2JY34_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative U3 small nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0242p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000242">
        <property type="protein sequence ID" value="TBU18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY34"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY34"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0242p0020"/>
    <dbReference type="OrthoDB" id="2195826at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="386"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="709" mass="82488" checksum="7128ACC84A4EE24B" modified="2019-07-31" version="1">MISILQIDRSFIPISDTPYFYVNEINFYTIFDSSIRITNLTTFKVKEIKFSKKILLFTIHNNKIITYDSALNIIDLFGNIIYKNNIQNYTILCMKGIEDFLIFLCSDKCVRRFCFTTRKIEILFKNKNSYKFLEIKNKKIFVVDEIGTVLYYDLTSNILKTHEFNEPIRSIYCAENTVNPCITVYISFVSGKLFIYEFITSSVIETLELKKDFLIFNYENQLYGINNNKIYFLQNDRTPKKLLNVYCEIIRTEIFFDNLILVTNEYDFIVVDLKDFKIKYILTGNADEITDMKMDNTKRIFISTNSEILRYLDLNDFNENGKFACKSYLLKGHRDAILSLDLSDEYLISGSRDKTAIIWRIEGKKIKKIKKIKTHTDSINGTAIFKDLIATAGKDKTLQIFKIKNDKIKTIFTKQVHSKEINSLEISKYRKMIATGSQDKSINIFDFNGTILKSIKSHTRGIWSVSFGQNILASSSSDTTVQIHNLDTYDSQILHGHTTAVVKCLVFNNETQVISSDLNGIIKIWDTKKLKCLNTLDIQNTKIWSLFYHNGLYTGTSDGQINFFIDITESHQTAIKKSKENLIQTNFLIQRSIEDKNYLQTISLLINKEILNNSDYTVIYSILEDNFCSEILSEIIEIIFTRKEAVINAINKFIISFKSVQIIDLLLRCLIDRKMLNEEDCFKIQKNLQKQFKGILDLYSNVICYDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY47</accession>
    <name>A0A4V2JY47_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0215p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000215">
        <property type="protein sequence ID" value="TBU19284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY47"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0215p0020"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU19284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="96" mass="11405" checksum="50DC19773C222C77" modified="2019-07-31" version="1">MNYENPYTKSKPYFTGNRRFKATKDLLKNQKNQKMEKVIINKSKLDEEGWYNIKTPLLTEQVENDLYYIKNRDILGDGSAKQVKDLKVFHLGKYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY56</accession>
    <name>A0A4V2JY56_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CWI37_0202p0020</name>
        <name evidence="9" type="ORF">CWI38_0208p0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FI-OER-3-3</strain>
            <strain evidence="9">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000202">
        <property type="protein sequence ID" value="TBU03975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000208">
        <property type="protein sequence ID" value="TBU19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY56"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY56"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0202p0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0208p0010"/>
    <dbReference type="OrthoDB" id="2192876at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU03975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <sequence length="232" mass="27509" checksum="7AB42684928C954D" modified="2019-07-31" version="1">MKILNVNTAVYKHKPNKNSKIKEIAYFMVPYKTDCYICLDFPDDPKILECRHILCEVCMEDCYMFYGFCPICKRTISKCFSVRWLFFTDYNIGDKIKLVKIDSSSLFDVPHIDVYSKNPFYDSYYENITQEDSKSKICKNISSVVSSKNIDIKKVNKNDYKKIPFYQSEDGQLIFLNPKSLKNLIFEHKIFKNLPEYIILKIYYIESYLDSTNYTFLEHLDSKCISFVYGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY60</accession>
    <name>A0A4V2JY60_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0187p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000187">
        <property type="protein sequence ID" value="TBU19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY60"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0187p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="403" mass="48280" checksum="EE2CA8E3EAE2C4AE" modified="2019-07-31" version="1">MNKDMKIHSFKSLLKIFPLVFILSCFFNAINNLNFIQILNPFRTFPIRIIISSIFYMTYQHFLNTTVPTFSYKNVYFVTQLTLLFISHLFYIPPYILKENIFYTIILISISTPLHHVSFSLIYTQNIGLFKYLQKERKRIVMVTVRNTKILFISFFTLTFIISVYNSLIYISLIFLIIFFMNLHFYITNTLYIYTYSLFNKSLLSPLSISYISNPITQIRRFYFNQYLQQSLTYNNVYLSSKISENIILFYKIELQKCITLLSNLKNVSNNFNMSKYTLIPLVIKKENKIFEKNNSLKESKDMVFIKKVRKWNFFNIFVEYVKYRIQLHFILQEYNGCIFYLKESLVYFKKMRKEKDPFGLVDVFIKDVKNSMSVFFETGVAVQEEIKINLSVSVLFKDYEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JY63</accession>
    <name>A0A4V2JY63_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0186p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000186">
        <property type="protein sequence ID" value="TBU19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JY63"/>
    <dbReference type="STRING" id="1176355.A0A4V2JY63"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0186p0040"/>
    <dbReference type="OrthoDB" id="10038074at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="299" mass="35273" checksum="E350130C64925296" modified="2019-07-31" version="1">MKIESKEEIEKKRKSLAEQNPIFFIRLRRLVKIIFYTILINHVLGFLIQICFDINKTLSTQIRTIINFLLSNFYCLIVFYKKRANENRDYTYFCVNNTNGVLMNLFSIILSNVNDILKEKMFHINRTVGYVEYFFMLTFLFVINSCVVYNSFLMIKFIENNLTKYPANICLTHLISAFLLFVGEKLIIMAVFIVARFIVSDTPSILQTENRREFDNNTVKDLSRIRPDLKMVRKKAQDSQSQSYVEGATKELRVGLKSFLSLDVLPKINSEEDLKVYEYIRTIYNPLNNSKKKRENIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYA5</accession>
    <name>A0A4V2JYA5_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_0089p0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="PITK01000089">
        <property type="protein sequence ID" value="TBU20323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYA5"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYA5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0089p0030"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU20323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="354" mass="41788" checksum="E9082121224D8F25" modified="2019-07-31" version="1">MDVFLARFKRFNIISGEMIARLEKPEDFHSFISKKIEISEHVAISTLFIGNGLDSMYMFEKINKRKLENLQTSIILDKNRLQRNPEAFKYLRTKKLLNIFNINESNFKNNFFSRIKEIFHVNHKKIFLFDSDILITGANMEDSYYKYKIDSFSNTDFIDRTEYCCPNIKIISFTEKTELRIFKEILNYNLKAIYISTAFLNFSNTLISGLKNRNVTIFTASPRCNTFKFNPTIEEIVKNIYTLNAIEILTKNNTVSYYEYDKENFYFHSKGFWAFEEDFCISIIGSSNYNVRSSSRDSELNFLVVSENKNVRNIFENEIKELLIVCKKVTLEDLKARNVSFISKVLKPIFKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYF3</accession>
    <name>A0A4V2JYF3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Myb-like DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0008p0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYF3"/>
    <dbReference type="STRING" id="1176355.A0A4V2JYF3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0060"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="175" mass="20444" checksum="533F904025065E07" modified="2019-07-31" version="1">MDPKLSHFLNNDNFKEERKRKIKKEELKVEIKEMSVSLPDKEQESPDILTIRENKIVIDHSATFTVKENTENFQVTNDTDKIITSLTYSKRVPAGRWPKNESDTFFDALSICGTDFTMINRFLPSKTRKQIKNKFLNEEKKNPHKIAAALNKHSTLNPNDFKRLSKFNIEDKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LIZ7</accession>
    <name>A0A4Q9LIZ7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2304p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002304">
        <property type="protein sequence ID" value="TBU08114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LIZ7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2304p0010"/>
    <dbReference type="OrthoDB" id="6093641at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="959" mass="107381" checksum="41AFA6F0C517D6E1" modified="2019-07-31" version="1" fragment="single">MCNRLGGDGGYGGSNKGDNKDSVSNRDRVSNRDNTNKDKDKDKDKDGVSNKNTTKNTNKDKDNDKDSVSNRDTTKDNDKDKNGNSVSLYTKMSYYFTSNKDNNTTINTNINNTIKSKHYTTFTDSTVISLTSNSYYIIALTVNTINIYTYNNTLLLHSKINNNNYSSLTPLNTNYILIGDNKGSVIVYSIKDKSNSKYCISKTPISKIGVYNTNSNKVCDGSMDGDSSKGDSNKGDNNKGNNKTSSNTSSKGDNKTSKSSSKGNNKTSKSSSKTSSKGNNNTSSKTSSKSKYINTILLHSNGMLYILSNTYKVLKTLYCDTFFLTDKGVYIIKDILNVLLLERSYIESYRDMCEDVKTYITNKDNTSNNTYITNKDNIVVTNTSTANTPTTNTYNTLYILRKYDKVFFINNKYICYNNNKITIIINNGIIKEIKVKHHIYDILFIKGVSNIKGDGNIKGDSNIGDSNIDVSNIKGDSNIKGVSNIGDSNIGDSNIKGDSNIKGDSNIKGVKNIGNSNITPCYLMVILTSKEIIYTDYNTLINKGIVNYNDRGVISTTNPTNTNNTNNTTNPTNTNNTNNTTNPTNTNNTTNPTNTNNTNNTSNNTINNNTINNNTGNYIFYINNMSIVNYDSNSVILKDNEYLYKYDINKRVLVKVLEIKDNKYIKKVLVYEDNVLFLYDSYLEDKGFRVYDVLDCYIGGCYLYVIKKNELSIYTMKYHRNDDEKGCNVSGEGVSGTSDTNTSFGKEVGDNTPLNKDMEDNTLLGNTEDKRLLNNDIQDNTPLNKDMEDNTLLGNTEDNTPLINNIEGNTPLNNTTDDNTPLNNTTEDNTPLNNINNTNTLLDKNLTNNTPNSLIYTLICSIEINILKTVCYNTIIYFITLNNTIKVDNSIYHMNVKCSDIYFYEYEGVIYVGIKNDCQFSFYREEDINKCFKKGLGNEDIVDNNIEDHICDGKGDNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LMP8</accession>
    <name>A0A4Q9LMP8_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2226p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002226">
        <property type="protein sequence ID" value="TBU08721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LMP8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2226p0010"/>
    <dbReference type="OrthoDB" id="2191633at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU08721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25790" checksum="956FFC82F530122C" modified="2019-07-31" version="1" fragment="single">IHLLLLNKYKFKSSKRIRSHTVQEILDNEYAELRVDTRIKTDVKIRCNRPDIFILDKRHNRITLIEVGITSQDSLQIVETEKLRKYDLLGNELGLIYKCSVEIIPCVMTWDGIVTKYHKTYVKRLQIPMNVEAYIQSIVLKKTVETISFDRRRGLESGPNAEESWERASLSVILGAEMHKQPIPPLKQVDNEEDDEPSTNTNEELELEEEIEVVEMVERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LNW4</accession>
    <name>A0A4Q9LNW4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_2015p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01002015">
        <property type="protein sequence ID" value="TBU10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LNW4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_2015p0010"/>
    <dbReference type="OrthoDB" id="5386133at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="171"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="287" mass="33484" checksum="32D4514DCBD1C91A" modified="2019-07-31" version="1" fragment="single">MSNSFSGKNTNEKKYDFHVGETPECIECENYNVLKCLVETLGSHDKNLPLTTIPSLRKQMVSINERERIIEKNIRRLFYKRGGDGRSKLTLEIKESLQTYVDLKYTKTLYELAEWVKCTFNVDVSTSTIDRALKEFHYTLKRVKLVPERRNTLSTIELRTNYATSFLTRPSRGRRNISAVAAVNKYVRIYHKIHERAVNGEDFKLSIKEINESCQRQGILTPIVVMDNARIHHYRGLNDDEEIASYRIKYLTPYSPFLNPIENVFSVWKNRVIRGGARTESQLRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LP32</accession>
    <name>A0A4Q9LP32_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CWI38_1937p0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001937">
        <property type="protein sequence ID" value="TBU10213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LP32"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LP32"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1937p0010"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU10213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="309" mass="36065" checksum="DA140C84F3C040F1" modified="2019-07-31" version="1">MEAEDFFKSNYNSSIRTIVYTKKGVRKISTYKFVETVGSGTFGIVMRVKKMNSYENLALKRVYIDSRYYQRELEILKKINHKNLLNLIEYFYSNVNKEGRFLNMLFQYSQNTLYDLIKVEDETEKIIFLYKQALDGLEYLHSLNICHRDIKPLNILVDSDGILKICDFGSAKVLENGTKNITYICSRHYRAPENLLGISSYDCKIDVWAMGCVFCEFYTRCPLFKGENNTDQLSKITEVVYISYSDALEMNLTYDETFTPIGIKNYLRKISVDTKLVDVIEMSLVFNPNKRASSTYLAQLPIFKNYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSD7</accession>
    <name>A0A4Q9LSD7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CWI38_1766p0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001766">
        <property type="protein sequence ID" value="TBU10430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSD7"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LSD7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1766p0010"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU10430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="134" mass="15164" checksum="5A82AC6B7051059A" modified="2019-07-31" version="1" fragment="single">PETPFYGGKFVVNIHIPDDYPFKSPSIGFVTKVFHPNVDENSGSICLDVLNQVWSPLYDLLNVVEIFLPQLLSYPNALDPLNSEAANMYINDKPKYEKVVKEYVDKYAIPNIKEEKTYNVDNSSSSVDSDSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSE0</accession>
    <name>A0A4Q9LSE0_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1184p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001184">
        <property type="protein sequence ID" value="TBU11483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSE0"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1184p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU11483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="55066" checksum="8E37219587BD148B" modified="2019-07-31" version="1" fragment="single">YSIVIGYTDKIGLILLNLRRIKVFKEIKKLEIQNSFLTKNNLRLLDWFTALEHLVLLDISIKHKNLFFPKYLSGKLINLKVLDISASSMNLNTNFCEIFTGLQSLYISVKKTSDYRTFENLIFPSKYYLLLRKISICFTNISLMNFFNTIANFKKLEDITLKSQNSTPSFSFLPICIPKYNSILKKLHLDNLYLGYYEFLRIYNFQNLKSLSFKNCTFSFINYIYFSSIKFANKLENLTIENCDNAYDIFLTIQLYKNLKILNIESSVWAGFANSFVIKNLNLHTIFFKCRDLSKIPIKIEGKNSKLKILEFSFCNFSANSLHLLELNVDYLKNIKYFTYSDNSLSPNDINCISNMYNCELLDISRCEFQNCHFHDIFLPNKVYKIKELYIYDLNLNKKDLIALRNLNFLLHLSISFCSIDRSSLYYLKKQYLKKLQSIDTCNCKIPDDIRILIQTEFGWELHSSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LSR8</accession>
    <name>A0A4Q9LSR8_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1559p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001559">
        <property type="protein sequence ID" value="TBU10771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LSR8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1559p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="135" mass="15521" checksum="F25C5C1EE4816D26" modified="2019-07-31" version="1">MTWDGIVTKYHKSHLKRLEIPMNVEAYIQSIVLKKTVETISFDRRRGLESGLNAEESWERASMGVIMRSEMHEEPIPPLKEAKTEEDGAKNFKPKYKAPFILQGGTTLEEPTNNINEESDLEEVTKVVKEVEENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LTT4</accession>
    <name>A0A4Q9LTT4_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0160 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_1063p0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001063">
        <property type="protein sequence ID" value="TBU11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LTT4"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LTT4"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1063p0010"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="252" mass="29386" checksum="6CEEF175CFE161BA" modified="2019-07-31" version="1" fragment="single">DAYDASRHRYDHHQISFDERFSEKYTIKMSSCGLIFKHFHERLLEKYGLYLDSKYYNFMVDEIYASYFLYADGMDNGIDIFDNSIAVRTFSNVMYELAKLNSNYNDGFYEALSVVSKDLEQFLTFKIKYWLPSLEILVSEMEKQSGDIFFTKQNDFSTETAFVAEKILNKDFKFAVCEVESNNFRIYAFQVERYKFKSKIALRKEWRGLRGAELKNVSKIEGCVFVHATGFTGGNETLKGAIKMCNGSLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW61</accession>
    <name>A0A4Q9LW61_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0697p0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000697">
        <property type="protein sequence ID" value="TBU12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW61"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0697p0020"/>
    <dbReference type="OrthoDB" id="2194483at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="213" mass="25328" checksum="589C30A17B390108" modified="2019-07-31" version="1">MSDTYFKIIQIIEKYDDLERKELIDFYIETCGNEISCKNNTSKNTFILIMDLIKLTEKYNLPFEKVKNVVLNAVELKVLHLRAIILDTIEIDYSADIESFYGCEKWMKNIIKDLKHTICGSKEVYTLFCKHFLEECLNVFVSGQNKFGFYGNQLIVNFIYFRKYISKFTDYNFQSFFETLISHFEENKFYGFKEILNKLKINKEIKNGGNQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LW68</accession>
    <name>A0A4Q9LW68_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CWI38_0592p0010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000592">
        <property type="protein sequence ID" value="TBU12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LW68"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0592p0010"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="560" mass="65058" checksum="2C4A62ABAE941D35" modified="2019-07-31" version="1">MNGIISVQIAERVMKIIKNQTDPSIIEYIVPLIIFSITNENRKMLMYLQKIFRKVDQYSKDNKMGSDNLYKIFTPTIFPNIECYDLQSINLQIEIVKRIFESNLTEIPCFLYEEALSSKLLSGVERLFHTRLNAKNLFSAINQTAISLINHHIGVLRLELADFSKLDDAVRAVLVKNKVHIRPGCKDRLYLSRTELGRDLNSVKLRSEHMLLLFLDRLEKSKEISTRRAAILRVENNNKTHLALIKGFLKVKYRLVEEVIKKSLEEAQLAKLYNEIEKRKLYSKLYNARKNELLSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVLWGADGMRQHCGKSGKTVDHLATRCEKMLGYGYTRRHNEVVRCLHLLLLNRYKYHSVQEIFDNEYAEIRVNTRIKTDVKIRNNRPEIFILDKKKNKITHIKVGITSQNSLQIVETEKLRKYDLLANELGLIYKCNVEIIPCDDLGQYLEVYIQSIVLNKTVETISSDRRRGLESGLNAEESWERASMDGAKNFKPKNKAPFISQGGTTLEEPTNNINKESDSEEETKLVKEVEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LXZ5</accession>
    <name>A0A4Q9LXZ5_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0510p0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000510">
        <property type="protein sequence ID" value="TBU13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LXZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0510p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="198" mass="23299" checksum="9FFF47F175157629" modified="2019-07-31" version="1">MIYDYKDKRAEFSSLDDTMLLLKSNTFGFFSKNHGHDYTRRHNESLDVWHTHLIHISLSLRNRLGVTLKEILENEHAMIRANTRIKPDDNTNENGNGFKEYRKIWKPENLGTYIQFIVLKKTVETISFNRRRELETSLCVILGAEMPKQPTSSLKQADNGEDGDKTENRKNILPLILNHNHRERTDNKHKRRVGFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9LZS1</accession>
    <name>A0A4Q9LZS1_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CWI38_0194p0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL-G-3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000194">
        <property type="protein sequence ID" value="TBU19819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9LZS1"/>
    <dbReference type="STRING" id="1176355.A0A4Q9LZS1"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0194p0020"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="294"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU19819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="564" mass="66016" checksum="27BE2493E8A1A8B4" modified="2019-07-31" version="1">MLENVNITEYFNSDPFVENYSLKTFFNDFIVQEIHENELCEETDIFDTLNAVKVLKFIREFAKIEIIDEKLENLVKAINQNRQKYFLNNEKNENIETIENIETIQNNKFDNFFVENNQRKLLFKIYIPNKTYRSVLHGFLQSHPLISTKTDNNIVSVFYISDNSKKYSFVLKKTNRDTLNACQIIASYLKISYNSIKFCGNKDKRAVTYQKMSITDISFYDLYQIALKLSEENNGISIYKIRTCVSGISLGTLKGNRFKIILRPKNRNENSLTENSNLQNNYDVEKIKMYLNNGFINYYGNQRFGKNMNNHIIGELIVTKKYKEAVEIIMEPISNESEQITQARNLYKEEKFKDAYELFPQRFIAEKTICKGKSRGLSDKKCIENIKKELKSIYLHSYQSYIFNKMASDRIKRGKNIQVGDLVLKRTKISSKEVTSGNDNISNSHKKLEDIKLDSEVFIFDKNIFNNILYDSKKEIYEEKETLEEKIETITDENLDLHTIYDVVIPLKVERGLKGGFRKLIEKTSDLSVSIENNIIYLEFSLSKSAYATMVIREIIGNDILYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2K7</accession>
    <name>A0A4Q9M2K7_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CWI37_0049p0030</name>
        <name evidence="8" type="ORF">CWI38_0107p0030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FI-OER-3-3</strain>
            <strain evidence="8">IL-G-3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITJ01000049">
        <property type="protein sequence ID" value="TBU05101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PITK01000107">
        <property type="protein sequence ID" value="TBU20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2K7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI37_0049p0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0107p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292362">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF112">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU05101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292362"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="42874" checksum="4B53F1AE6E555AF3" modified="2019-07-31" version="1">MADEFIKNTTIFNFPHELIHIEIRFDFFVIPEEFLSILCKCRFLKTLKLLNYELKKNINQILFKIIGNMKELETLWIEYDDLGDEIYNYLFKIERIKILKLNNSFYRGQTLNLATITNYKCLTELVLYNIRISENTLNEIFKYENLEVFSLELCDIRPIKSIKSIFFRSRNLKKLHLSGSILSYLKDKEILSKLNHLEILNLDNCTHNLCFLTKLSSHCNLRLLRLSVKSSVLCMNDLKRITMLEVLEDLNFYECRFFRCSFWEMGEYFKSFYSLLRLNLSGIELTANDIRYLKNFKNLKELFISPFYWEMYQINYGLKYLSRIYFYSKLNYDKRKKENYFNYLYEKNILGIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M2L3</accession>
    <name>A0A4Q9M2L3_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0008p0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000008">
        <property type="protein sequence ID" value="TBU20935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M2L3"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0008p0080"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020705450" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="89" mass="10239" checksum="0546AFF09E025FB8" modified="2019-07-31" version="1">MLCKLLGLAIVLNYSLNNYFKNVTEIYNIVNASRYLASTSRITASNIDKNIENDTEVCRDFEEYKTRIIECKDSNKIKRNLLNGDSVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3J7</accession>
    <name>A0A4Q9M3J7_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0122p0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000122">
        <property type="protein sequence ID" value="TBU20161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3J7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0122p0040"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="661" mass="79443" checksum="7A1EAC9C3B30F849" modified="2019-07-31" version="1">MVRNIYYITFLIKYVYSSRYDIYRKPRAYIDGEEDYWYENTQGYQSLQEPKEISLSILFRSPTRETHTTSHLRNESFDDQYMYANRHEYRPQQLFFPPYGEHTYKTSRTHFRFEEPFEYEESSRRKQRNRYLPYYREEKKHRNPGSDFEEMRFRASRDNSFDYKLKEELNERYESYNPRNLDERYHTERSDIYIENGLHNTEQKSKFCNPIYENSNIKDEDYVESYNCTEFRDKNGLKIEKHDSCSTMELYLSKIKKFSKIIDTHGKNYAVLENLVTEYIGFSDIQFFIEGDFSIDGYVLKSDNALFFELIDHIAANENGFWSQIDSDAMIKYLAEKLKESVERYDFCKPCSPLLSYAKNIVNLKYFIKSIIKEDINLVKNSCLWILLLKTAESLCNVQPNKIVCDKNIIGEVLSKEHKDFDMYNGDKNAFLVLKRLYMVYDKIARKIFRMTKIPENYIYMLDFIFINVIYRNKDIHISQGGYIYLSRVISDCIFQMNPKIIIFFISQLKNLGISKPKKFDSVYLINNLLITLYKNPHKVDSKIRLNFRLMYENMIDSYIELFENEFCGLVILRDKESLVKNELKHIDLIVQKHKNKKIFLERLDLKDLIDVAQDICVMLNHFIKVGLNNEFYSQKYIQKSTKDCNKRLKAIFKILEIYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4B2</accession>
    <name>A0A4Q9M4B2_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0018p0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000018">
        <property type="protein sequence ID" value="TBU20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4B2"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0018p0100"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="671" mass="78097" checksum="2A40A3DC92430A22" modified="2019-07-31" version="1">MSQRNFEVFGFVLNREISATDDTSCEDTATLFERIGVHKCLGIIEDNRSNLPLSSLEDSKEISIGRAAILKVENTNITHLALMKDFLLNNILSIKIEDNLTNYTFNSELSAQDQRYSNNVFVKEESTIELHKEAADNDHDDTCDIKQETIAASFSTNDLLAKNSNNFNKTGSRIKKSYFKKNPHYTYGSHKRNKLYRSYPKNYDTGRSSVSSTRCDSYDCERLEALKINKLEPCCWDRYSEEQDDGFKKRKIPANLSNAEVEDKSTLIRSYSDFMEDINSSPFKKRTRMSKSQPESTKKTLKLKLGPPPTGYFKEMINTKRRSYAVFSDSKEDLCYTDIQTFISGDFYIDANRIHKDPTPFINLIDSVAEKEKNFWDKFEKYDILCHLSGNMVAYIEKVNLCDDDSPLFVYYSGLIHFKHFLRNIIAHNINLVKNSCLWTLLLKYVQFLSIIPIKNEHRNTSVKTCYSQYEDYDMYGGNRNIFHDMYIGFSRVISDCILRIYPDEIIIFLRQIQKQSFFDLNCKEYFRALSSFLRNMCSSSTCNDYKDICEFKIFYKKIILAYIDFLKYDAPQSESFYDEDGALRKSVSDVKIYFESSDIEKIASNCVDLTRMMKFSEALCVIFNHYIKVGLNDQAYSDVCINMSALLCKKRMENIYTNSEIDDEKQHCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M529</accession>
    <name>A0A4Q9M529_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CWI38_0036p0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000036">
        <property type="protein sequence ID" value="TBU20676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M529"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0036p0050"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU20676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="340" mass="39918" checksum="34CABE54CD649038" modified="2019-07-31" version="1">MLLQLLDCLEKSKEISTRRAAILKVENNNITHLSLIKGFLKVKYSLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNKAVFCYIQDRNVFWGADGVCQHCNQSKKTVDDLATRYEKMLVHDYTRRHNEVVRCIHLLLLNKYKFKSSKRIRSHSVQEILYNEYAEIRVDTIIKTYYDLLANELGLIYRCSVEIIPYVMTWDGIVTKYHKSHIKRLEKPKNLEAYIQSIVLKKTVETISFERRRRLEELGRASIGVIMRAEMHEEPTPPLKEAKRKEDFAKNFKPKNKALLISQGGTTLEEPTNNINKESDFEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JX71</accession>
    <name>A0A4V2JX71_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_1622p0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01001622">
        <property type="protein sequence ID" value="TBU10662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JX71"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1622p0010"/>
    <dbReference type="OrthoDB" id="2193117at2759"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU10662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="280" mass="32263" checksum="CB846952C302B558" modified="2019-07-31" version="1" fragment="single">MFNWLKEIKTSIIADKIEVCIQQGDRVSVYKYLGIIEDSRGIPTLSSFEEVQSKLISRVERLCHTRLNAKNLFSAINQHAISLINYHIGVLRLEPADFSKLDDAVRAVLLKNKIHLRPGCKERLYLSRTELGRGLHSVELRSEHMLLQLLDCLEKSKEISTRRAAILKVENNNKTHLALIKGFLKVKYRLVEEVTKKSLEEAQLAKLYNEIEKRKLHSKLYNARKNELVSVSDSSRWLKRGNIRPRNEAVFCYIQDRNVFWGADGVCQHCGKSGKTVDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXH6</accession>
    <name>A0A4V2JXH6_9MICR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CWI38_1012p0030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL-G-3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="PITK01001012">
        <property type="protein sequence ID" value="TBU11852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXH6"/>
    <dbReference type="STRING" id="1176355.A0A4V2JXH6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_1012p0030"/>
    <dbReference type="OrthoDB" id="2196211at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF5">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="38"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU11852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="314" mass="35997" checksum="E9710A55F404A8E0" modified="2019-07-31" version="1">MLDIRIKCEKSLLENLDLEENGYVQINGKNNYLLEKLQDLKAVRLSSGGTSLNTFIFLSKKGNIPLYFIGSVGSDKYLKILENELDILNIKYSFEIFDNNRTAKCFVLLNGRQRSLVTDLGASTCLSLKYVDTCLCNLPKNVFFYMSGFMIAAHLELSFHILDILKKNQLILNLSSYTLFSGSEYFFIKKYFDISNVVVGNFEEFYSFYKRVFGKEPINIRQILVELGYKNQTLICTDGGKDIYYTKNGKVYSSKIDKYLGDNVDTCGAGDAFAAGILYGFYNKYSIEEIIEIGKDWSEEYILENTKMIQELIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JXN9</accession>
    <name>A0A4V2JXN9_9MICR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CWI38_0736p0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hamiltosporidium tvaerminnensis</name>
        <dbReference type="NCBI Taxonomy" id="1176355"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Dubosqiidae</taxon>
            <taxon>Hamiltosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Pombert J.-F."/>
                <person name="Haag K.L."/>
                <person name="Ebert D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IL-G-3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PITK01000736">
        <property type="protein sequence ID" value="TBU12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JXN9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:CWI38_0736p0030"/>
    <dbReference type="Proteomes" id="UP000292282">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292282"/>
        </source>
    </evidence>
    <sequence length="178" mass="20963" checksum="5134A229FB060FEC" modified="2019-07-31" version="1">MFIFNGNQKKYRNSENGILGKRRKKGLTVVERSLKIFYGKIEHRKEFSLHLRKEGILGNHLILNYTEFDRSFAENSEIEIKLLGFDLNAYFEKEGIIFNLENSQTPTEAALSHMMQPGFEKTETSEVMRMNTEEINHSRNNIIYKSDSKDILKLDLELFFEKIFQANLEIQAKKYPIF</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>